locus-tag	class	description
B7L28_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
B7L28_RS00010	COG0592	DNA-directed DNA polymerase activity
B7L28_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B7L28_RS00035	COG0187	DNA topoisomerase II activity
B7L28_RS00040	COG0833	amino acid
B7L28_RS00060	COG1253	flavin adenine dinucleotide binding
B7L28_RS00095	COG0859	PFAM glycosyl transferase family 9
B7L28_RS00120	COG0438	transferase activity, transferring glycosyl groups
B7L28_RS00140	COG0561	phosphatase activity
B7L28_RS00145	COG1660	Displays ATPase and GTPase activities
B7L28_RS00150	COG0391	Required for morphogenesis under gluconeogenic growth conditions
B7L28_RS00155	COG1481	regulation of sporulation
B7L28_RS00165	COG0540	Belongs to the ATCase OTCase family
B7L28_RS00170	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B7L28_RS00185	COG0543	2 iron, 2 sulfur cluster binding
B7L28_RS00190	COG0167	dihydroorotate dehydrogenase activity
B7L28_RS00195	COG0583	DNA-binding transcription factor activity
B7L28_RS00205	COG1739	Uncharacterized protein family UPF0029
B7L28_RS00210	COG2217	Heavy metal translocating P-type atpase
B7L28_RS00220	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
B7L28_RS00225	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B7L28_RS00245	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
B7L28_RS00250	COG0336	Belongs to the RNA methyltransferase TrmD family
B7L28_RS00285	COG4752	Belongs to the RNA methyltransferase TrmD family
B7L28_RS00295	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
B7L28_RS00300	COG0632	four-way junction helicase activity
B7L28_RS00305	COG2255	four-way junction helicase activity
B7L28_RS00310	COG2247	cell wall binding repeat
B7L28_RS00310	COG2385	sporulation resulting in formation of a cellular spore
B7L28_RS00320	COG0343	queuine tRNA-ribosyltransferase activity
B7L28_RS00325	COG1862	Preprotein translocase
B7L28_RS00335	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B7L28_RS00340	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B7L28_RS00345	COG2814	Major facilitator Superfamily
B7L28_RS00410	COG0497	DNA recombination
B7L28_RS00425	COG0497	DNA recombination
B7L28_RS00430	COG0497	DNA recombination
B7L28_RS00470	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B7L28_RS00470	COG4797	methyltransferase
B7L28_RS00525	COG0501	Belongs to the peptidase M48B family
B7L28_RS00540	COG0811	peptide transport
B7L28_RS00545	COG0848	biopolymer transport protein
B7L28_RS00555	COG4771	TonB-dependent receptor
B7L28_RS00565	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B7L28_RS00570	COG1120	ATPase activity
B7L28_RS00590	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B7L28_RS00595	COG1120	ATPase activity
B7L28_RS00620	COG4206	TonB-dependent receptor
B7L28_RS00625	COG0436	Aminotransferase
B7L28_RS00645	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
B7L28_RS00665	COG4221	oxidoreductase activity
B7L28_RS00685	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B7L28_RS00690	COG0747	negative chemotaxis
B7L28_RS00695	COG0444	Belongs to the ABC transporter superfamily
B7L28_RS00730	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B7L28_RS00735	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B7L28_RS00740	COG0066	3-isopropylmalate dehydratase activity
B7L28_RS00745	COG0473	3-isopropylmalate dehydrogenase activity
B7L28_RS00775	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
B7L28_RS00780	COG3550	peptidyl-serine autophosphorylation
B7L28_RS00805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B7L28_RS00820	COG0561	phosphatase activity
B7L28_RS00830	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B7L28_RS00830	COG0519	Catalyzes the synthesis of GMP from XMP
B7L28_RS00885	COG0456	acetyltransferase
B7L28_RS00890	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B7L28_RS00895	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B7L28_RS00900	COG1121	(ABC) transporter
B7L28_RS00905	COG0803	Belongs to the bacterial solute-binding protein 9 family
B7L28_RS00930	COG1151	hydroxylamine reductase activity
B7L28_RS00935	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
B7L28_RS00945	COG2223	nitrite transmembrane transporter activity
B7L28_RS00950	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B7L28_RS00955	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
B7L28_RS00960	COG1140	nitrate reductase beta subunit
B7L28_RS00965	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
B7L28_RS00970	COG2181	nitrate reductase activity
B7L28_RS00985	COG2814	Major facilitator Superfamily
B7L28_RS00990	COG0583	DNA-binding transcription factor activity
B7L28_RS00995	COG1279	arginine transmembrane transporter activity
B7L28_RS01000	COG2855	membrane
B7L28_RS01005	COG0288	reversible hydration of carbon dioxide
B7L28_RS01015	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B7L28_RS01020	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
B7L28_RS01035	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B7L28_RS01040	COG1121	(ABC) transporter
B7L28_RS01045	COG0803	Belongs to the bacterial solute-binding protein 9 family
B7L28_RS01080	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B7L28_RS01085	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B7L28_RS01090	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
B7L28_RS01095	COG1882	Formate acetyltransferase
B7L28_RS01120	COG2011	ABC-type metal ion transport system permease component
B7L28_RS01130	COG0471	metal ion transport
B7L28_RS01150	COG1196	nuclear chromosome segregation
B7L28_RS01175	COG3659	wide pore channel activity
B7L28_RS01180	COG1879	ABC-type sugar transport system periplasmic component
B7L28_RS01185	COG1172	Belongs to the binding-protein-dependent transport system permease family
B7L28_RS01190	COG1129	ABC transporter
B7L28_RS01195	COG1869	D-ribose catabolic process
B7L28_RS01200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B7L28_RS01215	COG1122	ATPase activity
B7L28_RS01220	COG1122	ATPase activity
B7L28_RS01245	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
B7L28_RS01250	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
B7L28_RS01255	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
B7L28_RS01260	COG0131	Imidazoleglycerol-phosphate dehydratase
B7L28_RS01265	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
B7L28_RS01270	COG0107	imidazoleglycerol-phosphate synthase activity
B7L28_RS01275	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
B7L28_RS01280	COG0140	phosphoribosyl-ATP diphosphatase activity
B7L28_RS01285	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B7L28_RS01290	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
B7L28_RS01295	COG1966	Carbon starvation protein
B7L28_RS01300	COG0004	ammonium transporteR
B7L28_RS01350	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
B7L28_RS01360	COG1045	serine acetyltransferase
B7L28_RS01365	COG0783	Belongs to the Dps family
B7L28_RS01380	COG1914	H( )-stimulated, divalent metal cation uptake system
B7L28_RS01390	COG3022	response to hydroperoxide
B7L28_RS01395	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
B7L28_RS01405	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B7L28_RS01410	COG2731	YhcH YjgK YiaL family protein
B7L28_RS01425	COG2184	nucleotidyltransferase activity
B7L28_RS01435	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B7L28_RS01460	COG0512	Glutamine amidotransferase of anthranilate synthase
B7L28_RS01460	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B7L28_RS01465	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B7L28_RS01470	COG0134	indole-3-glycerol-phosphate synthase activity
B7L28_RS01475	COG0133	tryptophan synthase activity
B7L28_RS01480	COG0159	tryptophan synthase activity
B7L28_RS01490	COG3152	Membrane
B7L28_RS01500	COG0626	cystathionine gamma-synthase activity
B7L28_RS01505	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
B7L28_RS01510	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
B7L28_RS01515	COG2873	o-acetylhomoserine
B7L28_RS01535	COG0701	Predicted permease
B7L28_RS01540	COG0523	cobalamin synthesis protein
B7L28_RS01545	COG2195	Cleaves the N-terminal amino acid of tripeptides
B7L28_RS01550	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
B7L28_RS01560	COG0252	asparaginase activity
B7L28_RS01570	COG0668	transmembrane transport
B7L28_RS01575	COG1686	Belongs to the peptidase S11 family
B7L28_RS01585	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
B7L28_RS01595	COG2080	2 iron, 2 sulfur cluster binding
B7L28_RS01600	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B7L28_RS01600	COG2080	2 iron, 2 sulfur cluster binding
B7L28_RS01610	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
B7L28_RS01615	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
B7L28_RS01615	COG3608	succinylglutamate desuccinylase aspartoacylase
B7L28_RS01620	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
B7L28_RS01620	COG3608	succinylglutamate desuccinylase aspartoacylase
B7L28_RS01630	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
B7L28_RS01640	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
B7L28_RS01645	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B7L28_RS01655	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B7L28_RS01660	COG0180	Tryptophanyl-tRNA synthetase
B7L28_RS01675	COG0765	amino acid transport
B7L28_RS01680	COG1126	abc transporter atp-binding protein
B7L28_RS01690	COG0589	response to stress
B7L28_RS01695	COG0640	Transcriptional regulator
B7L28_RS01705	COG0725	ABC transporter, periplasmic molybdate-binding protein
B7L28_RS01710	COG4149	molybdate abc transporter
B7L28_RS01715	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
B7L28_RS01735	COG1592	Rubrerythrin
B7L28_RS01745	COG0709	Synthesizes selenophosphate from selenide and ATP
B7L28_RS01760	COG3177	Filamentation induced by cAMP protein fic
B7L28_RS01765	COG0778	Nitroreductase
B7L28_RS01770	COG2261	transglycosylase associated protein
B7L28_RS01775	COG3237	CsbD-like
B7L28_RS01780	COG0012	GTP binding
B7L28_RS01785	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B7L28_RS01795	COG3468	outer membrane autotransporter barrel domain protein
B7L28_RS01800	COG0436	Aminotransferase
B7L28_RS01815	COG0360	Binds together with S18 to 16S ribosomal RNA
B7L28_RS01820	COG0629	single-stranded DNA binding
B7L28_RS01825	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
B7L28_RS01835	COG0220	tRNA (guanine-N7-)-methyltransferase activity
B7L28_RS01840	COG0772	Belongs to the SEDS family
B7L28_RS01845	COG2233	PERMEase
B7L28_RS01850	COG1030	water channel activity
B7L28_RS01885	COG2195	Cleaves the N-terminal amino acid of tripeptides
B7L28_RS01900	COG2040	homocysteine
B7L28_RS01905	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B7L28_RS01910	COG1116	anion transmembrane transporter activity
B7L28_RS01925	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B7L28_RS01925	COG0426	domain, Protein
B7L28_RS01930	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B7L28_RS01935	COG0583	DNA-binding transcription factor activity
B7L28_RS01940	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B7L28_RS01955	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
B7L28_RS01960	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
B7L28_RS01965	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
B7L28_RS01970	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
B7L28_RS01975	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
B7L28_RS01980	COG0138	bifunctional purine biosynthesis protein purh
B7L28_RS01985	COG0151	Belongs to the GarS family
B7L28_RS01990	COG1169	isochorismate synthase
B7L28_RS01995	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
B7L28_RS02000	COG0596	Alpha beta hydrolase
B7L28_RS02005	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
B7L28_RS02010	COG0318	PFAM AMP-dependent synthetase and ligase
B7L28_RS02080	COG1649	PFAM Uncharacterised BCR, COG1649
B7L28_RS02080	COG0726	polysaccharide deacetylase
B7L28_RS02085	COG4632	Exopolysaccharide biosynthesis protein
B7L28_RS02085	COG5434	Belongs to the glycosyl hydrolase 28 family
B7L28_RS02095	COG0859	PFAM glycosyl transferase family 9
B7L28_RS02110	COG5002	protein histidine kinase activity
B7L28_RS02115	COG0745	RESPONSE REGULATOR receiver
B7L28_RS02120	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B7L28_RS02125	COG1695	Transcriptional regulator
B7L28_RS02140	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
B7L28_RS02145	COG0284	orotidine-5'-phosphate decarboxylase activity
B7L28_RS02150	COG2176	DNA-directed DNA polymerase activity
B7L28_RS02170	COG1464	Belongs to the NlpA lipoprotein family
B7L28_RS02175	COG1575	Belongs to the MenA family. Type 1 subfamily
B7L28_RS02190	COG0251	oxidation-reduction process
B7L28_RS02195	COG3681	Belongs to the UPF0597 family
B7L28_RS02200	COG2223	nitrite transmembrane transporter activity
B7L28_RS02220	COG2860	membrane
B7L28_RS02240	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B7L28_RS02245	COG2011	ABC-type metal ion transport system permease component
B7L28_RS02250	COG4496	protein, YerC YecD
B7L28_RS02270	COG3339	Conserved Protein
B7L28_RS02275	COG0824	Thioesterase
B7L28_RS02280	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
B7L28_RS02305	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
B7L28_RS02310	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B7L28_RS02320	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
B7L28_RS02325	COG0281	malic enzyme
B7L28_RS02355	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
B7L28_RS02360	COG1914	H( )-stimulated, divalent metal cation uptake system
B7L28_RS02365	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
B7L28_RS02370	COG1984	allophanate hydrolase subunit 2
B7L28_RS02385	COG0534	Mate efflux family protein
B7L28_RS02390	COG0519	Catalyzes the synthesis of GMP from XMP
B7L28_RS02400	COG0628	permease
B7L28_RS02410	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B7L28_RS02415	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
B7L28_RS02420	COG2226	methyltransferase
B7L28_RS02445	COG0726	polysaccharide deacetylase
B7L28_RS02450	COG0521	Mo-molybdopterin cofactor biosynthetic process
B7L28_RS02460	COG0306	phosphate transporter
B7L28_RS02465	COG1959	2 iron, 2 sulfur cluster binding
B7L28_RS02470	COG1271	oxidase subunit
B7L28_RS02475	COG1294	oxidase, subunit
B7L28_RS02480	COG4988	ABC transporter
B7L28_RS02500	COG0601	transmembrane transport
B7L28_RS02505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B7L28_RS02510	COG0444	Belongs to the ABC transporter superfamily
B7L28_RS02515	COG4608	Belongs to the ABC transporter superfamily
B7L28_RS02525	COG4166	transmembrane transport
B7L28_RS02530	COG1619	proteins homologs of microcin C7 resistance protein MccF
B7L28_RS02535	COG1473	amidohydrolase
B7L28_RS02540	COG0488	(ABC) transporter
B7L28_RS02545	COG0302	gtp cyclohydrolase
B7L28_RS02550	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
B7L28_RS02555	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
B7L28_RS02560	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
B7L28_RS02560	COG0302	gtp cyclohydrolase
B7L28_RS02570	COG2261	transglycosylase associated protein
B7L28_RS02575	COG0039	L-malate dehydrogenase activity
B7L28_RS02585	COG1098	S1 RNA binding domain
B7L28_RS02595	COG0037	tRNA processing
B7L28_RS02605	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B7L28_RS02630	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
B7L28_RS02635	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B7L28_RS02640	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B7L28_RS02645	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B7L28_RS02650	COG1982	Orn Lys Arg decarboxylase major
B7L28_RS02655	COG0531	amino acid
B7L28_RS02665	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
B7L28_RS02670	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B7L28_RS02675	COG1494	fructose-1,6-bisphosphatase
B7L28_RS02680	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B7L28_RS02705	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
B7L28_RS02710	COG1127	ABC transporter
B7L28_RS02750	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B7L28_RS02755	COG1560	Kdo2-lipid A biosynthetic process
B7L28_RS02760	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
B7L28_RS02765	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B7L28_RS02770	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B7L28_RS02775	COG3494	Protein of unknown function (DUF1009)
B7L28_RS02780	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B7L28_RS02785	COG1132	(ABC) transporter
B7L28_RS02790	COG1519	Transferase
B7L28_RS02795	COG1663	tetraacyldisaccharide 4'-kinase activity
B7L28_RS02800	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
B7L28_RS02805	COG2877	3-deoxy-8-phosphooctulonate synthase activity
B7L28_RS02815	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
B7L28_RS02835	COG1137	ATPase activity
B7L28_RS02845	COG4372	Transposase
B7L28_RS02855	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B7L28_RS02865	COG0497	DNA recombination
B7L28_RS02885	COG3585	molybdate ion transport
B7L28_RS02900	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
B7L28_RS02905	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
B7L28_RS02910	COG3584	3D domain protein
B7L28_RS02910	COG3583	domain protein
B7L28_RS02915	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B7L28_RS02920	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B7L28_RS02930	COG0193	aminoacyl-tRNA hydrolase activity
B7L28_RS02935	COG1982	Orn Lys Arg decarboxylase major
B7L28_RS02945	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
B7L28_RS02950	COG1774	PSP1 C-terminal conserved region
B7L28_RS02955	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
B7L28_RS02960	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
B7L28_RS02965	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B7L28_RS02965	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B7L28_RS02970	COG0084	hydrolase, TatD family'
B7L28_RS02985	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
B7L28_RS02990	COG1388	LysM domain
B7L28_RS02990	COG3584	3D domain protein
B7L28_RS02995	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B7L28_RS02995	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B7L28_RS03000	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
B7L28_RS03005	COG0583	DNA-binding transcription factor activity
B7L28_RS03010	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
B7L28_RS03015	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B7L28_RS03020	COG0786	glutamate:sodium symporter activity
B7L28_RS03025	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
B7L28_RS03030	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B7L28_RS03045	COG1918	ferrous iron import across plasma membrane
B7L28_RS03045	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
B7L28_RS03095	COG0298	carbon dioxide binding
B7L28_RS03125	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B7L28_RS03135	COG1268	BioY protein
B7L28_RS03145	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
B7L28_RS03155	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B7L28_RS03165	COG0166	Belongs to the GPI family
B7L28_RS03230	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B7L28_RS03240	COG3475	LICD family
B7L28_RS03300	COG1328	CTP reductase activity
B7L28_RS03305	COG0602	queuosine metabolic process
B7L28_RS03325	COG1773	rubredoxin
B7L28_RS03340	COG0333	Belongs to the bacterial ribosomal protein bL32 family
B7L28_RS03350	COG0416	fatty acid biosynthetic process
B7L28_RS03355	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B7L28_RS03365	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
B7L28_RS03370	COG1028	Short-chain dehydrogenase reductase Sdr
B7L28_RS03375	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B7L28_RS03380	COG2070	2-Nitropropane dioxygenase
B7L28_RS03385	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B7L28_RS03390	COG0571	ribonuclease III activity
B7L28_RS03400	COG1196	nuclear chromosome segregation
B7L28_RS03405	COG0552	protein localization to endoplasmic reticulum
B7L28_RS03415	COG0556	nucleotide-excision repair
B7L28_RS03420	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B7L28_RS03425	COG0322	excinuclease ABC activity
B7L28_RS03435	COG0861	Integral membrane protein TerC family
B7L28_RS03440	COG0861	Integral membrane protein TerC family
B7L28_RS03445	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B7L28_RS03465	COG4771	TonB-dependent receptor
B7L28_RS03510	COG1032	radical SAM domain protein
B7L28_RS03530	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B7L28_RS03535	COG0179	Fumarylacetoacetate (FAA) hydrolase
B7L28_RS03545	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B7L28_RS03560	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B7L28_RS03570	COG0471	metal ion transport
B7L28_RS03575	COG1362	aminopeptidase activity
B7L28_RS03580	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
B7L28_RS03585	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
B7L28_RS03595	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
B7L28_RS03600	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
B7L28_RS03600	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
B7L28_RS03605	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B7L28_RS03610	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
B7L28_RS03615	COG0859	PFAM glycosyl transferase family 9
B7L28_RS03620	COG0859	PFAM glycosyl transferase family 9
B7L28_RS03630	COG1362	aminopeptidase activity
B7L28_RS03650	COG4120	Belongs to the binding-protein-dependent transport system permease family
B7L28_RS03655	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
B7L28_RS03660	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
B7L28_RS03665	COG1185	polyribonucleotide nucleotidyltransferase activity
B7L28_RS03670	COG0756	dUTP diphosphatase activity
B7L28_RS03675	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B7L28_RS03715	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
B7L28_RS03720	COG0268	Binds directly to 16S ribosomal RNA
B7L28_RS03725	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B7L28_RS03725	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B7L28_RS03745	COG0779	Required for maturation of 30S ribosomal subunits
B7L28_RS03750	COG0195	Participates in both transcription termination and antitermination
B7L28_RS03760	COG1358	cellular component organization or biogenesis
B7L28_RS03765	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
B7L28_RS03765	COG3170	Tfp pilus assembly protein FimV
B7L28_RS03770	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
B7L28_RS03785	COG0196	riboflavin kinase activity
B7L28_RS03795	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B7L28_RS03800	COG1040	competence protein
B7L28_RS03815	COG0765	amino acid transport
B7L28_RS03825	COG1278	Cold shock
B7L28_RS03830	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
B7L28_RS03835	COG0653	protein targeting
B7L28_RS03860	COG3959	Transketolase, thiamine diphosphate binding domain
B7L28_RS03865	COG3958	Transketolase
B7L28_RS03870	COG2884	Cell division ATP-binding protein ftsE
B7L28_RS03875	COG2177	Part of the ABC transporter FtsEX involved in
B7L28_RS03880	COG4942	peptidase
B7L28_RS03885	COG0793	Belongs to the peptidase S41A family
B7L28_RS03890	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B7L28_RS03900	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
B7L28_RS03905	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
B7L28_RS03915	COG1713	HD superfamily hydrolase involved in NAD metabolism
B7L28_RS03920	COG1316	TRANSCRIPTIONal
B7L28_RS03925	COG0799	negative regulation of ribosome biogenesis
B7L28_RS03930	COG2996	Protein conserved in bacteria
B7L28_RS03935	COG0569	domain protein
B7L28_RS03940	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B7L28_RS03945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B7L28_RS03975	COG1683	Conserved Protein
B7L28_RS03990	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
B7L28_RS03995	COG1187	pseudouridine synthase activity
B7L28_RS04000	COG2081	HI0933 family
B7L28_RS04015	COG0539	negative regulation of cytoplasmic translation
B7L28_RS04015	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
B7L28_RS04020	COG1160	GTP binding
B7L28_RS04025	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
B7L28_RS04030	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
B7L28_RS04035	COG0742	ribosomal rna small subunit methyltransferase
B7L28_RS04040	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
B7L28_RS04060	COG1561	YicC-like family, N-terminal region
B7L28_RS04070	COG0194	GDP metabolic process
B7L28_RS04075	COG1758	RNA polymerase activity
B7L28_RS04080	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B7L28_RS04085	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
B7L28_RS04090	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
B7L28_RS04095	COG0242	peptide deformylase activity
B7L28_RS04110	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B7L28_RS04110	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B7L28_RS04115	COG0820	rRNA (adenine-C2-)-methyltransferase activity
B7L28_RS04120	COG0631	protein serine/threonine phosphatase activity
B7L28_RS04125	COG0515	serine threonine protein kinase
B7L28_RS04125	COG2815	serine threonine protein kinase
B7L28_RS04130	COG1162	GTPase activity
B7L28_RS04135	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
B7L28_RS04140	COG0052	Belongs to the universal ribosomal protein uS2 family
B7L28_RS04145	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
B7L28_RS04150	COG0528	UMP kinase activity
B7L28_RS04155	COG0233	cytoplasmic translational termination
B7L28_RS04165	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B7L28_RS04170	COG4589	Belongs to the CDS family
B7L28_RS04175	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
B7L28_RS04180	COG0750	zinc metalloprotease
B7L28_RS04185	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
B7L28_RS04190	COG0442	prolyl-tRNA aminoacylation
B7L28_RS04195	COG0613	PHP domain protein
B7L28_RS04205	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B7L28_RS04210	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
B7L28_RS04215	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
B7L28_RS04220	COG2521	methyltransferase
B7L28_RS04220	COG2136	Putative SAM-dependent methyltransferase
B7L28_RS04225	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
B7L28_RS04230	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
B7L28_RS04235	COG0482	sulfurtransferase activity
B7L28_RS04240	COG0481	GTPase activity
B7L28_RS04245	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B7L28_RS04255	COG1420	regulation of RNA biosynthetic process
B7L28_RS04265	COG0443	Heat shock 70 kDa protein
B7L28_RS04270	COG0484	heat shock protein binding
B7L28_RS04280	COG1385	rRNA (uridine-N3-)-methyltransferase activity
B7L28_RS04285	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B7L28_RS04290	COG0537	adenosine 5'-monophosphoramidase activity
B7L28_RS04295	COG0828	Belongs to the bacterial ribosomal protein bS21 family
B7L28_RS04300	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B7L28_RS04305	COG0174	glutamine synthetase
B7L28_RS04315	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
B7L28_RS04320	COG1132	(ABC) transporter
B7L28_RS04325	COG1132	(ABC) transporter
B7L28_RS04330	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B7L28_RS04345	COG4492	Belongs to the UPF0735 family
B7L28_RS04350	COG0460	homoserine dehydrogenase
B7L28_RS04355	COG0083	homoserine kinase activity
B7L28_RS04365	COG0105	UTP biosynthetic process
B7L28_RS04370	COG2096	Adenosyltransferase
B7L28_RS04385	COG1492	cobalamin metabolic process
B7L28_RS04395	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
B7L28_RS04405	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B7L28_RS04410	COG0406	alpha-ribazole phosphatase activity
B7L28_RS04415	COG1187	pseudouridine synthase activity
B7L28_RS04420	COG0006	proline dipeptidase activity
B7L28_RS04425	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B7L28_RS04445	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B7L28_RS04455	COG1722	exodeoxyribonuclease VII activity
B7L28_RS04470	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
B7L28_RS04475	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B7L28_RS04485	COG1438	arginine binding
B7L28_RS04490	COG0497	DNA recombination
B7L28_RS04495	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
B7L28_RS04500	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
B7L28_RS04505	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B7L28_RS04510	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B7L28_RS04525	COG2720	vancomycin resistance protein
B7L28_RS04530	COG0671	phosphoesterase, PA-phosphatase related
B7L28_RS04560	COG0402	S-adenosylhomocysteine deaminase activity
B7L28_RS04565	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
B7L28_RS04570	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
B7L28_RS04575	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
B7L28_RS04580	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
B7L28_RS04600	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B7L28_RS04600	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B7L28_RS04605	COG0028	Belongs to the TPP enzyme family
B7L28_RS04630	COG1555	photosystem II stabilization
B7L28_RS04630	COG1596	polysaccharide export
B7L28_RS04635	COG2309	aminopeptidase activity
B7L28_RS04645	COG0495	leucyl-tRNA aminoacylation
B7L28_RS04650	COG3858	chitin binding
B7L28_RS04650	COG1388	LysM domain
B7L28_RS04655	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
B7L28_RS04660	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
B7L28_RS04665	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B7L28_RS04670	COG0758	DNA mediated transformation
B7L28_RS04675	COG0606	chelatase, subunit chli
B7L28_RS04680	COG0792	nuclease activity
B7L28_RS04695	COG0335	large ribosomal subunit rRNA binding
B7L28_RS04705	COG0751	glycine-tRNA ligase activity
B7L28_RS04710	COG0752	glycyl-tRNA synthetase alpha subunit
B7L28_RS04720	COG3328	transposase activity
B7L28_RS04755	COG3875	lactate racemase activity
B7L28_RS04765	COG1691	(AIR) carboxylase
B7L28_RS04770	COG0482	sulfurtransferase activity
B7L28_RS04780	COG1253	flavin adenine dinucleotide binding
B7L28_RS04785	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
B7L28_RS04795	COG1702	phosphate starvation-inducible protein PhoH
B7L28_RS04800	COG1242	4 iron, 4 sulfur cluster binding
B7L28_RS04815	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B7L28_RS04820	COG0154	amidase activity
B7L28_RS04830	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B7L28_RS04835	COG0210	DNA helicase
B7L28_RS04840	COG1227	inorganic diphosphatase activity
B7L28_RS04860	COG0156	8-amino-7-oxononanoate synthase activity
B7L28_RS04865	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
B7L28_RS04915	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
B7L28_RS04920	COG0557	exoribonuclease II activity
B7L28_RS04940	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B7L28_RS04945	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
B7L28_RS04950	COG0215	cysteine-tRNA ligase activity
B7L28_RS04955	COG0385	Bile acid
B7L28_RS04960	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B7L28_RS04965	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
B7L28_RS04965	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
B7L28_RS04970	COG4956	integral membrane protein (PIN domain superfamily)
B7L28_RS04975	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
B7L28_RS04980	COG0542	response to heat
B7L28_RS04985	COG3869	Catalyzes the specific phosphorylation of arginine residues in
B7L28_RS04990	COG3880	PFAM UvrB UvrC protein
B7L28_RS04995	COG4463	regulation of RNA biosynthetic process
B7L28_RS05010	COG0822	iron-sulfur transferase activity
B7L28_RS05015	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B7L28_RS05030	COG0396	ATPase activity
B7L28_RS05045	COG0459	protein refolding
B7L28_RS05050	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
B7L28_RS05065	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B7L28_RS05070	COG0456	acetyltransferase
B7L28_RS05075	COG1214	PFAM Peptidase M22, glycoprotease
B7L28_RS05080	COG0802	atpase or kinase
B7L28_RS05085	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
B7L28_RS05100	COG2333	competence protein COMEC
B7L28_RS05100	COG0658	competence protein
B7L28_RS05105	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
B7L28_RS05105	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
B7L28_RS05130	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
B7L28_RS05140	COG1183	phosphatidylcholine synthase activity
B7L28_RS05145	COG0688	phosphatidylethanolamine metabolic process
B7L28_RS05150	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
B7L28_RS05155	COG0517	IMP dehydrogenase activity
B7L28_RS05155	COG0516	GMP reductase activity
B7L28_RS05160	COG1942	4-Oxalocrotonate Tautomerase
B7L28_RS05165	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
B7L28_RS05170	COG0227	Belongs to the bacterial ribosomal protein bL28 family
B7L28_RS05175	COG0232	Belongs to the dGTPase family. Type 2 subfamily
B7L28_RS05180	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
B7L28_RS05185	COG0517	IMP dehydrogenase activity
B7L28_RS05190	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B7L28_RS05190	COG0574	Belongs to the PEP-utilizing enzyme family
B7L28_RS05220	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B7L28_RS05225	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
B7L28_RS05230	COG1193	negative regulation of DNA recombination
B7L28_RS05235	COG0826	peptidase U32
B7L28_RS05240	COG0072	phenylalanine-tRNA ligase activity
B7L28_RS05240	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B7L28_RS05245	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
B7L28_RS05255	COG1136	(ABC) transporter
B7L28_RS05255	COG0577	efflux transmembrane transporter activity
B7L28_RS05260	COG1136	(ABC) transporter
B7L28_RS05275	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
B7L28_RS05320	COG2165	general secretion pathway protein
B7L28_RS05325	COG1459	type II secretion system
B7L28_RS05330	COG2805	Type II/IV secretion system protein
B7L28_RS05345	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
B7L28_RS05350	COG0149	triose-phosphate isomerase activity
B7L28_RS05355	COG0126	phosphoglycerate kinase activity
B7L28_RS05375	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B7L28_RS05380	COG0698	ribose 5-phosphate isomerase
B7L28_RS05385	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B7L28_RS05390	COG0009	L-threonylcarbamoyladenylate synthase
B7L28_RS05395	COG2890	protein-(glutamine-N5) methyltransferase activity
B7L28_RS05400	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
B7L28_RS05405	COG3872	metal-dependent enzyme
B7L28_RS05410	COG0254	rRNA binding
B7L28_RS05425	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
B7L28_RS05445	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
B7L28_RS05450	COG3856	small basic protein
B7L28_RS05465	COG1181	Belongs to the D-alanine--D-alanine ligase family
B7L28_RS05470	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B7L28_RS05475	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B7L28_RS05480	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B7L28_RS05485	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B7L28_RS05490	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B7L28_RS05495	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B7L28_RS05500	COG4839	cell division protein FtsL
B7L28_RS05505	COG0275	rRNA processing
B7L28_RS05510	COG2001	Belongs to the MraZ family
B7L28_RS05520	COG3118	belongs to the thioredoxin family
B7L28_RS05530	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B7L28_RS05550	COG2033	superoxide reductase activity
B7L28_RS05570	COG4822	anaerobic cobalamin biosynthetic process
B7L28_RS05620	COG1120	ATPase activity
B7L28_RS05625	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B7L28_RS05665	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
B7L28_RS05670	COG1666	GTP binding
B7L28_RS05680	COG0564	pseudouridine synthase activity
B7L28_RS05685	COG0191	fructose-bisphosphate aldolase activity
B7L28_RS05690	COG2244	polysaccharide biosynthetic process
B7L28_RS05700	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
B7L28_RS05715	COG0546	phosphoglycolate phosphatase activity
B7L28_RS05785	COG1401	restriction endodeoxyribonuclease activity
B7L28_RS05840	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
B7L28_RS05850	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
B7L28_RS05855	COG0471	metal ion transport
B7L28_RS05865	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B7L28_RS05880	COG0826	peptidase U32
B7L28_RS05885	COG4122	O-methyltransferase activity
B7L28_RS05895	COG3906	Belongs to the UPF0473 family
B7L28_RS05900	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
B7L28_RS05905	COG4472	Bacterial protein of unknown function (DUF965)
B7L28_RS05910	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B7L28_RS05915	COG0791	NLP P60 protein
B7L28_RS05915	COG1388	LysM domain
B7L28_RS05920	COG0463	Glycosyl transferase, family 2
B7L28_RS05930	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
B7L28_RS05960	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
B7L28_RS05975	COG0302	gtp cyclohydrolase
B7L28_RS05980	COG0602	queuosine metabolic process
B7L28_RS05990	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B7L28_RS05995	COG0358	DNA primase activity
B7L28_RS06000	COG1418	mRNA catabolic process
B7L28_RS06010	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
B7L28_RS06015	COG1058	Belongs to the CinA family
B7L28_RS06015	COG1546	Belongs to the CinA family
B7L28_RS06020	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B7L28_RS06055	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
B7L28_RS06065	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B7L28_RS06070	COG0735	belongs to the Fur family
B7L28_RS06075	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B7L28_RS06080	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B7L28_RS06085	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
B7L28_RS06085	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
B7L28_RS06090	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
B7L28_RS06095	COG0390	transport system, permease component
B7L28_RS06100	COG4619	ABC transporter
B7L28_RS06105	COG0211	Belongs to the bacterial ribosomal protein bL27 family
B7L28_RS06115	COG0261	This protein binds to 23S rRNA in the presence of protein L20
B7L28_RS06120	COG1971	Probably functions as a manganese efflux pump
B7L28_RS06125	COG1530	ribonuclease E activity
B7L28_RS06140	COG0772	Belongs to the SEDS family
B7L28_RS06145	COG2894	cell division
B7L28_RS06150	COG0768	penicillin binding
B7L28_RS06165	COG1077	Cell shape determining protein MreB Mrl
B7L28_RS06170	COG2003	Belongs to the UPF0758 family
B7L28_RS06175	COG0424	maF-like protein
B7L28_RS06195	COG1323	Belongs to the UPF0348 family
B7L28_RS06205	COG0564	pseudouridine synthase activity
B7L28_RS06210	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
B7L28_RS06225	COG0471	metal ion transport
B7L28_RS06225	COG0490	domain, Protein
B7L28_RS06235	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
B7L28_RS06240	COG0511	ligase activity, forming carbon-carbon bonds
B7L28_RS06250	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B7L28_RS06255	COG0346	lactoylglutathione lyase activity
B7L28_RS06265	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B7L28_RS06265	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B7L28_RS06270	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B7L28_RS06270	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B7L28_RS06275	COG0427	acetyl-CoA hydrolase
B7L28_RS06285	COG0285	dihydrofolate synthase activity
B7L28_RS06290	COG0525	valine-tRNA ligase activity
B7L28_RS06295	COG0805	protein transport
B7L28_RS06300	COG0142	geranyltranstransferase activity
B7L28_RS06305	COG0218	Necessary for normal cell division and for the maintenance of normal septation
B7L28_RS06310	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B7L28_RS06315	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
B7L28_RS06320	COG0740	serine-type endopeptidase activity
B7L28_RS06325	COG0544	peptidyl-prolyl cis-trans isomerase activity
B7L28_RS06330	COG0516	GMP reductase activity
B7L28_RS06330	COG0517	IMP dehydrogenase activity
B7L28_RS06335	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
B7L28_RS06340	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
B7L28_RS06345	COG1850	ribulose-bisphosphate carboxylase activity
B7L28_RS06365	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B7L28_RS06375	COG1970	mechanosensitive ion channel activity
B7L28_RS06380	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B7L28_RS06395	COG2837	iron assimilation
B7L28_RS06415	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B7L28_RS06425	COG2233	PERMEase
B7L28_RS06430	COG3404	Formiminotransferase-cyclodeaminase
B7L28_RS06440	COG0471	metal ion transport
B7L28_RS06445	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
B7L28_RS06450	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
B7L28_RS06455	COG2207	Transcriptional regulator
B7L28_RS06470	COG2207	Transcriptional regulator
B7L28_RS06475	COG0303	'Molybdopterin
B7L28_RS06485	COG3859	Proton-coupled thiamine transporter YuaJ
B7L28_RS06495	COG2223	nitrite transmembrane transporter activity
B7L28_RS06505	COG0519	Catalyzes the synthesis of GMP from XMP
B7L28_RS06520	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
B7L28_RS06540	COG1332	CRISPR-associated RAMP protein, Csm5 family
B7L28_RS06545	COG1567	CRISPR-associated RAMP protein, Csm4 family
B7L28_RS06550	COG1337	RAMP superfamily
B7L28_RS06560	COG1353	crispr-associated protein
B7L28_RS06565	COG3069	C4-dicarboxylate transmembrane transporter activity
B7L28_RS06570	COG1473	amidohydrolase
B7L28_RS06580	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B7L28_RS06585	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B7L28_RS06590	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
B7L28_RS06600	COG1473	amidohydrolase
B7L28_RS06605	COG0288	reversible hydration of carbon dioxide
B7L28_RS06610	COG0440	acetolactate synthase activity
B7L28_RS06615	COG0028	Belongs to the TPP enzyme family
B7L28_RS06635	COG2226	methyltransferase
B7L28_RS06645	COG1704	LemA family
B7L28_RS06685	COG1217	gtp-binding protein TYPA
B7L28_RS06690	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
B7L28_RS06700	COG3679	Belongs to the UPF0342 family
B7L28_RS06705	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
B7L28_RS06710	COG0315	cyclic pyranopterin monophosphate synthase activity
B7L28_RS06715	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
B7L28_RS06735	COG0569	domain protein
B7L28_RS06740	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B7L28_RS06745	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B7L28_RS06765	COG0848	biopolymer transport protein
B7L28_RS06770	COG0811	peptide transport
B7L28_RS06775	COG4771	TonB-dependent receptor
B7L28_RS06780	COG0662	Cupin 2, conserved barrel domain protein
B7L28_RS06780	COG2207	Transcriptional regulator
B7L28_RS06815	COG0488	(ABC) transporter
B7L28_RS06825	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B7L28_RS06830	COG0776	regulation of translation
B7L28_RS06835	COG3956	TIGRFAM MazG family protein
B7L28_RS06840	COG2244	polysaccharide biosynthetic process
B7L28_RS06845	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
B7L28_RS06905	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
B7L28_RS06915	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
B7L28_RS06920	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
B7L28_RS06930	COG0419	ATPase involved in DNA repair
B7L28_RS06935	COG0420	3'-5' exonuclease activity
B7L28_RS06940	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
B7L28_RS06945	COG0735	belongs to the Fur family
B7L28_RS06950	COG0513	Belongs to the DEAD box helicase family
B7L28_RS06965	COG3048	D-serine ammonia-lyase activity
B7L28_RS06995	COG1012	belongs to the aldehyde dehydrogenase family
B7L28_RS07000	COG2183	response to ionizing radiation
B7L28_RS07005	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
B7L28_RS07010	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
B7L28_RS07015	COG0514	ATP-dependent DNA helicase (RecQ)
B7L28_RS07020	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B7L28_RS07030	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B7L28_RS07030	COG4797	methyltransferase
B7L28_RS07040	COG0583	DNA-binding transcription factor activity
B7L28_RS07055	COG0670	Belongs to the BI1 family
B7L28_RS07075	COG2301	Belongs to the HpcH HpaI aldolase family
B7L28_RS07080	COG3052	prosthetic group binding
B7L28_RS07085	COG0471	metal ion transport
B7L28_RS07090	COG0583	DNA-binding transcription factor activity
B7L28_RS07180	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B7L28_RS07185	COG0113	porphobilinogen synthase activity
B7L28_RS07190	COG1587	Uroporphyrinogen-III synthase
B7L28_RS07190	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B7L28_RS07195	COG0181	hydroxymethylbilane synthase activity
B7L28_RS07200	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
B7L28_RS07210	COG2302	S4 RNA-binding domain
B7L28_RS07215	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B7L28_RS07220	COG1799	cell septum assembly
B7L28_RS07230	COG1496	oxidoreductase activity
B7L28_RS07240	COG2323	membrane
B7L28_RS07255	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
B7L28_RS07260	COG1119	ATPase activity
B7L28_RS07270	COG0028	Belongs to the TPP enzyme family
B7L28_RS07275	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B7L28_RS07280	COG0129	dihydroxy-acid dehydratase activity
B7L28_RS07285	COG0471	metal ion transport
B7L28_RS07300	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B7L28_RS07305	COG0363	glucosamine-6-phosphate deaminase activity
B7L28_RS07310	COG1024	Enoyl-CoA hydratase
B7L28_RS07315	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B7L28_RS07320	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
B7L28_RS07325	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
B7L28_RS07330	COG0583	DNA-binding transcription factor activity
B7L28_RS07335	COG1742	UPF0060 membrane protein
B7L28_RS07385	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
B7L28_RS07390	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
B7L28_RS07395	COG0287	Prephenate dehydrogenase
B7L28_RS07400	COG0534	Mate efflux family protein
B7L28_RS07415	COG1013	pyruvate-flavodoxin oxidoreductase activity
B7L28_RS07420	COG0674	pyruvate-flavodoxin oxidoreductase activity
B7L28_RS07420	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
B7L28_RS07425	COG0101	tRNA pseudouridine synthase activity
B7L28_RS07430	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
B7L28_RS07435	COG1122	ATPase activity
B7L28_RS07440	COG1122	ATPase activity
B7L28_RS07445	COG0203	ribosomal protein L17
B7L28_RS07450	COG0202	RNA polymerase activity
B7L28_RS07460	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
B7L28_RS07465	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B7L28_RS07485	COG0201	protein transport
B7L28_RS07490	COG0200	Binds to the 23S rRNA
B7L28_RS07495	COG1841	ribosomal large subunit assembly
B7L28_RS07500	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
B7L28_RS07505	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
B7L28_RS07510	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
B7L28_RS07515	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
B7L28_RS07525	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
B7L28_RS07535	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
B7L28_RS07545	COG0255	Belongs to the universal ribosomal protein uL29 family
B7L28_RS07550	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
B7L28_RS07555	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
B7L28_RS07560	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
B7L28_RS07565	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
B7L28_RS07570	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
B7L28_RS07575	COG0089	rRNA binding
B7L28_RS07580	COG0088	Forms part of the polypeptide exit tunnel
B7L28_RS07585	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
B7L28_RS07590	COG0051	transcription antitermination factor activity, RNA binding
B7L28_RS07595	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B7L28_RS07605	COG0049	tRNA binding
B7L28_RS07610	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
B7L28_RS07620	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B7L28_RS07625	COG0085	RNA polymerase activity
B7L28_RS07630	COG1027	Aspartate ammonia-lyase
B7L28_RS07635	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
B7L28_RS07640	COG0222	ribosome binding
B7L28_RS07650	COG0081	regulation of translation
B7L28_RS07655	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
B7L28_RS07660	COG0250	Participates in transcription elongation, termination and antitermination
B7L28_RS07665	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B7L28_RS07670	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B7L28_RS07685	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B7L28_RS07725	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
B7L28_RS07735	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B7L28_RS07740	COG0768	penicillin binding
B7L28_RS07745	COG0617	tRNA 3'-terminal CCA addition
B7L28_RS07750	COG1760	l-serine dehydratase
B7L28_RS07755	COG1760	l-serine dehydratase
B7L28_RS07760	COG1151	hydroxylamine reductase activity
B7L28_RS07825	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
B7L28_RS07830	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B7L28_RS07835	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
B7L28_RS07840	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B7L28_RS07845	COG0356	it plays a direct role in the translocation of protons across the membrane
B7L28_RS07860	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
B7L28_RS07865	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B7L28_RS07870	COG2848	UPF0210 protein
B7L28_RS07875	COG3830	Belongs to the UPF0237 family
B7L28_RS07880	COG0033	Phosphoglucomutase
B7L28_RS07885	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B7L28_RS07890	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
B7L28_RS07895	COG1802	Transcriptional regulator
B7L28_RS07900	COG1115	amino acid carrier protein
B7L28_RS07905	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B7L28_RS07915	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
B7L28_RS07920	COG0708	Exodeoxyribonuclease III
B7L28_RS07970	COG0747	negative chemotaxis
B7L28_RS07980	COG0444	Belongs to the ABC transporter superfamily
B7L28_RS07985	COG0747	negative chemotaxis
B7L28_RS07990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B7L28_RS07995	COG0601	transmembrane transport
B7L28_RS08000	COG4608	Belongs to the ABC transporter superfamily
B7L28_RS08005	COG0444	Belongs to the ABC transporter superfamily
B7L28_RS08010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B7L28_RS08020	COG0747	negative chemotaxis
B7L28_RS08035	COG4139	cobalamin transport
B7L28_RS08040	COG1120	ATPase activity
B7L28_RS08045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B7L28_RS08050	COG4774	siderophore transport
B7L28_RS08070	COG0531	amino acid
B7L28_RS08075	COG0165	Argininosuccinate lyase
B7L28_RS08080	COG0137	argininosuccinate synthase activity
B7L28_RS08085	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B7L28_RS08095	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B7L28_RS08100	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B7L28_RS08105	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
B7L28_RS08110	COG1757	Na H antiporter
B7L28_RS08115	COG1105	Belongs to the carbohydrate kinase PfkB family
B7L28_RS08120	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B7L28_RS08120	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B7L28_RS08120	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B7L28_RS08155	COG0450	alkyl hydroperoxide reductase
B7L28_RS08165	COG0504	CTP synthase activity
B7L28_RS08170	COG0018	arginyl-trna synthetase
B7L28_RS08190	COG0561	phosphatase activity
B7L28_RS08200	COG1114	Component of the transport system for branched-chain amino acids
B7L28_RS08205	COG0243	molybdopterin cofactor binding
B7L28_RS08210	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
B7L28_RS08215	COG1620	l-lactate permease
B7L28_RS08220	COG2814	Major facilitator Superfamily
B7L28_RS08230	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
B7L28_RS08245	COG0494	nUDIX hydrolase
B7L28_RS08265	COG1454	alcohol dehydrogenase
B7L28_RS08280	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B7L28_RS08285	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B7L28_RS08300	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
B7L28_RS08305	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
B7L28_RS08310	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B7L28_RS08315	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
B7L28_RS08320	COG1605	Chorismate mutase
B7L28_RS08320	COG0077	Prephenate dehydratase
B7L28_RS08340	COG0710	3-dehydroquinate dehydratase activity
B7L28_RS08345	COG2814	Major facilitator Superfamily
B7L28_RS08350	COG1959	2 iron, 2 sulfur cluster binding
B7L28_RS08355	COG2252	PERMEase
B7L28_RS08375	COG1113	amino acid transport
B7L28_RS08390	COG0564	pseudouridine synthase activity
B7L28_RS08405	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
B7L28_RS08410	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
B7L28_RS08415	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
B7L28_RS08425	COG0067	glutamate synthase
B7L28_RS08425	COG0069	glutamate synthase activity
B7L28_RS08425	COG0070	glutamate synthase
B7L28_RS08435	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
B7L28_RS08440	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
B7L28_RS08445	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
B7L28_RS08450	COG4717	serine-type aminopeptidase activity
B7L28_RS08455	COG0420	3'-5' exonuclease activity
B7L28_RS08460	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
B7L28_RS08470	COG0564	pseudouridine synthase activity
B7L28_RS08490	COG0656	L-ascorbic acid biosynthetic process
B7L28_RS08495	COG1687	branched-chain amino acid
B7L28_RS08500	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
B7L28_RS08505	COG1979	alcohol dehydrogenase
B7L28_RS08515	COG0778	Nitroreductase
B7L28_RS08515	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
B7L28_RS08520	COG2146	nitrite reductase [NAD(P)H] activity
B7L28_RS08520	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B7L28_RS08530	COG1556	Lactate utilization protein
B7L28_RS08535	COG1139	Iron-sulfur cluster binding protein
B7L28_RS08540	COG0247	lactate metabolic process
B7L28_RS08550	COG3266	domain, Protein
B7L28_RS08550	COG1361	Conserved repeat domain
B7L28_RS08550	COG2911	Protein conserved in bacteria
B7L28_RS08565	COG1297	OPT oligopeptide transporter protein
B7L28_RS08575	COG1408	metallophosphoesterase
B7L28_RS08585	COG1051	belongs to the nudix hydrolase family
B7L28_RS08630	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B7L28_RS08645	COG1597	lipid kinase activity
B7L28_RS08650	COG1074	ATP-dependent DNA helicase activity
B7L28_RS08655	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
B7L28_RS08690	COG2217	Heavy metal translocating P-type atpase
B7L28_RS08700	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B7L28_RS08705	COG0305	Participates in initiation and elongation during chromosome replication
B7L28_RS08710	COG0359	binds to the 23S rRNA
B7L28_RS08715	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
B7L28_RS08725	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
B7L28_RS08730	COG3152	Membrane
B7L28_RS08740	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B7L28_RS08740	COG1116	anion transmembrane transporter activity
B7L28_RS08745	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B7L28_RS08755	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
B7L28_RS08760	COG0586	Pfam SNARE associated Golgi protein
B7L28_RS08770	COG2048	Heterodisulfide reductase, subunit B
B7L28_RS08775	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B7L28_RS08780	COG1053	succinate dehydrogenase
B7L28_RS08785	COG0745	RESPONSE REGULATOR receiver
B7L28_RS08790	COG3850	Histidine kinase
B7L28_RS08790	COG5002	protein histidine kinase activity
B7L28_RS08795	COG2733	membrane
B7L28_RS08800	COG2733	membrane
B7L28_RS08810	COG1733	regulation of RNA biosynthetic process
B7L28_RS08815	COG2910	NAD(P)H-binding
B7L28_RS08830	COG0280	phosphate acetyltransferase
B7L28_RS08835	COG1373	ATPase (AAA superfamily
B7L28_RS08850	COG0493	'glutamate synthase
B7L28_RS08875	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
B7L28_RS08880	COG2824	Alkylphosphonate utilization operon protein PhnA
B7L28_RS08885	COG0789	Transcriptional regulator
B7L28_RS08970	COG3866	Pectate lyase
B7L28_RS08980	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B7L28_RS08990	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
B7L28_RS09000	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
B7L28_RS09015	COG0848	biopolymer transport protein
B7L28_RS09020	COG0811	peptide transport
B7L28_RS09030	COG1703	isobutyryl-CoA mutase activity
B7L28_RS09035	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B7L28_RS09035	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B7L28_RS09040	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B7L28_RS09040	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B7L28_RS09070	COG0277	FAD linked oxidase domain protein
B7L28_RS09080	COG3041	Addiction module toxin RelE StbE family
B7L28_RS09090	COG3875	lactate racemase activity
B7L28_RS09100	COG1454	alcohol dehydrogenase
B7L28_RS09105	COG1472	Belongs to the glycosyl hydrolase 3 family
B7L28_RS09115	COG1994	Peptidase M50
B7L28_RS09130	COG1846	Transcriptional regulator
B7L28_RS09160	COG1393	Belongs to the ArsC family
B7L28_RS09230	COG3152	Membrane
B7L28_RS09265	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B7L28_RS09270	COG2271	Major facilitator Superfamily
B7L28_RS09285	COG1489	DNA binding
B7L28_RS09300	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B7L28_RS09350	COG0739	heme binding
B7L28_RS09350	COG0741	lytic transglycosylase activity
B7L28_RS09350	COG1196	nuclear chromosome segregation
B7L28_RS09360	COG1160	GTP binding
B7L28_RS09365	COG1475	DNA binding
B7L28_RS09370	COG1192	Involved in chromosome partitioning
B7L28_RS09385	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
B7L28_RS09385	COG0646	methionine synthase
B7L28_RS09390	COG0357	Ribosomal RNA small subunit methyltransferase G
B7L28_RS09395	COG0445	tRNA wobble uridine modification
B7L28_RS09400	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
B7L28_RS09405	COG1847	R3H domain protein
B7L28_RS09410	COG0706	membrane insertase activity
B7L28_RS09415	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
B7L28_RS09420	COG0594	ribonuclease P activity
B7L28_RS09425	COG0230	Belongs to the bacterial ribosomal protein bL34 family