locus-tag	class	description
VPAR_RS00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
VPAR_RS00025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
VPAR_RS00040	COG0187	DNA topoisomerase II activity
VPAR_RS00045	COG0833	amino acid
VPAR_RS00060	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VPAR_RS00065	COG1253	flavin adenine dinucleotide binding
VPAR_RS00085	COG1216	Glycosyl transferase, family 2
VPAR_RS00085	COG1442	glycosyl transferase family 8
VPAR_RS00090	COG0463	Glycosyl transferase, family 2
VPAR_RS00115	COG3594	Acyltransferase
VPAR_RS00120	COG0562	UDP-galactopyranose mutase
VPAR_RS00135	COG0438	transferase activity, transferring glycosyl groups
VPAR_RS00140	COG0726	polysaccharide deacetylase
VPAR_RS00145	COG3475	LICD family
VPAR_RS00150	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
VPAR_RS00160	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VPAR_RS00295	COG0811	peptide transport
VPAR_RS00300	COG0848	biopolymer transport protein
VPAR_RS00310	COG4771	TonB-dependent receptor
VPAR_RS00320	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VPAR_RS00330	COG4206	TonB-dependent receptor
VPAR_RS00340	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VPAR_RS00345	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VPAR_RS00350	COG1120	ATPase activity
VPAR_RS00375	COG4206	TonB-dependent receptor
VPAR_RS00380	COG0436	Aminotransferase
VPAR_RS00385	COG0640	Transcriptional regulator
VPAR_RS00395	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
VPAR_RS00410	COG4221	oxidoreductase activity
VPAR_RS00430	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VPAR_RS00435	COG0747	negative chemotaxis
VPAR_RS00440	COG0444	Belongs to the ABC transporter superfamily
VPAR_RS00475	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VPAR_RS00480	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
VPAR_RS00485	COG0066	3-isopropylmalate dehydratase activity
VPAR_RS00490	COG0473	3-isopropylmalate dehydrogenase activity
VPAR_RS00505	COG1196	nuclear chromosome segregation
VPAR_RS00530	COG1879	ABC-type sugar transport system periplasmic component
VPAR_RS00535	COG1172	Belongs to the binding-protein-dependent transport system permease family
VPAR_RS00540	COG1129	ABC transporter
VPAR_RS00545	COG1869	D-ribose catabolic process
VPAR_RS00550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VPAR_RS00585	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
VPAR_RS00595	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
VPAR_RS00600	COG1122	ATPase activity
VPAR_RS00605	COG1122	ATPase activity
VPAR_RS00620	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
VPAR_RS00630	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
VPAR_RS00635	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
VPAR_RS00640	COG0131	Imidazoleglycerol-phosphate dehydratase
VPAR_RS00645	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
VPAR_RS00650	COG0107	imidazoleglycerol-phosphate synthase activity
VPAR_RS00655	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
VPAR_RS00665	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VPAR_RS00670	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
VPAR_RS00675	COG1966	Carbon starvation protein
VPAR_RS00695	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VPAR_RS00705	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
VPAR_RS00710	COG1045	serine acetyltransferase
VPAR_RS00715	COG0783	Belongs to the Dps family
VPAR_RS00730	COG1914	H( )-stimulated, divalent metal cation uptake system
VPAR_RS00740	COG3022	response to hydroperoxide
VPAR_RS00745	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
VPAR_RS00750	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VPAR_RS00755	COG2731	YhcH YjgK YiaL family protein
VPAR_RS00760	COG0697	spore germination
VPAR_RS00780	COG3069	C4-dicarboxylate transmembrane transporter activity
VPAR_RS00800	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
VPAR_RS00800	COG0512	Glutamine amidotransferase of anthranilate synthase
VPAR_RS00805	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
VPAR_RS00810	COG0134	indole-3-glycerol-phosphate synthase activity
VPAR_RS00815	COG0133	tryptophan synthase activity
VPAR_RS00820	COG0159	tryptophan synthase activity
VPAR_RS00835	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VPAR_RS00860	COG1132	(ABC) transporter
VPAR_RS00865	COG0535	radical SAM domain protein
VPAR_RS00875	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
VPAR_RS00885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VPAR_RS00895	COG0561	phosphatase activity
VPAR_RS00905	COG0656	L-ascorbic acid biosynthetic process
VPAR_RS00910	COG0518	GMP synthase (glutamine-hydrolyzing) activity
VPAR_RS00910	COG0519	Catalyzes the synthesis of GMP from XMP
VPAR_RS00990	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VPAR_RS00995	COG1120	ATPase activity
VPAR_RS01000	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VPAR_RS01005	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VPAR_RS01010	COG1121	(ABC) transporter
VPAR_RS01015	COG0803	Belongs to the bacterial solute-binding protein 9 family
VPAR_RS01040	COG0583	DNA-binding transcription factor activity
VPAR_RS01045	COG1151	hydroxylamine reductase activity
VPAR_RS01050	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
VPAR_RS01065	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
VPAR_RS01070	COG0420	3'-5' exonuclease activity
VPAR_RS01075	COG4717	serine-type aminopeptidase activity
VPAR_RS01080	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
VPAR_RS01085	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
VPAR_RS01090	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
VPAR_RS01095	COG3253	May function as heme-dependent peroxidase
VPAR_RS01100	COG2223	nitrite transmembrane transporter activity
VPAR_RS01105	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VPAR_RS01110	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
VPAR_RS01115	COG1140	nitrate reductase beta subunit
VPAR_RS01120	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
VPAR_RS01125	COG2181	nitrate reductase activity
VPAR_RS01135	COG3206	protein involved in exopolysaccharide biosynthesis
VPAR_RS01145	COG2814	Major facilitator Superfamily
VPAR_RS01150	COG0583	DNA-binding transcription factor activity
VPAR_RS01160	COG2855	membrane
VPAR_RS01165	COG0288	reversible hydration of carbon dioxide
VPAR_RS01175	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
VPAR_RS01180	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VPAR_RS01190	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VPAR_RS01195	COG1121	(ABC) transporter
VPAR_RS01200	COG0803	Belongs to the bacterial solute-binding protein 9 family
VPAR_RS01245	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VPAR_RS01250	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VPAR_RS01260	COG2217	Heavy metal translocating P-type atpase
VPAR_RS01265	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VPAR_RS01270	COG1882	Formate acetyltransferase
VPAR_RS01295	COG2011	ABC-type metal ion transport system permease component
VPAR_RS01310	COG0471	metal ion transport
VPAR_RS01325	COG0626	cystathionine gamma-synthase activity
VPAR_RS01330	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
VPAR_RS01335	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
VPAR_RS01340	COG2873	o-acetylhomoserine
VPAR_RS01360	COG0701	Predicted permease
VPAR_RS01365	COG0523	cobalamin synthesis protein
VPAR_RS01370	COG2195	Cleaves the N-terminal amino acid of tripeptides
VPAR_RS01375	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
VPAR_RS01385	COG0252	asparaginase activity
VPAR_RS01395	COG0668	transmembrane transport
VPAR_RS01400	COG1686	Belongs to the peptidase S11 family
VPAR_RS01410	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
VPAR_RS01420	COG2080	2 iron, 2 sulfur cluster binding
VPAR_RS01425	COG1529	Aldehyde oxidase and xanthine dehydrogenase
VPAR_RS01425	COG2080	2 iron, 2 sulfur cluster binding
VPAR_RS01445	COG3608	succinylglutamate desuccinylase aspartoacylase
VPAR_RS01445	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
VPAR_RS01455	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
VPAR_RS01460	COG4856	YbbR-like protein
VPAR_RS01465	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
VPAR_RS01470	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VPAR_RS01475	COG1794	racemase activity, acting on amino acids and derivatives
VPAR_RS01490	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
VPAR_RS01495	COG0180	Tryptophanyl-tRNA synthetase
VPAR_RS01510	COG0765	amino acid transport
VPAR_RS01515	COG1126	abc transporter atp-binding protein
VPAR_RS01525	COG0589	response to stress
VPAR_RS01530	COG0640	Transcriptional regulator
VPAR_RS01540	COG0725	ABC transporter, periplasmic molybdate-binding protein
VPAR_RS01545	COG4149	molybdate abc transporter
VPAR_RS01550	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
VPAR_RS01575	COG1592	Rubrerythrin
VPAR_RS01585	COG0709	Synthesizes selenophosphate from selenide and ATP
VPAR_RS01600	COG0778	Nitroreductase
VPAR_RS01605	COG2261	transglycosylase associated protein
VPAR_RS01615	COG0012	GTP binding
VPAR_RS01620	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
VPAR_RS01625	COG1120	ATPase activity
VPAR_RS01630	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VPAR_RS01635	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VPAR_RS01650	COG0436	Aminotransferase
VPAR_RS01665	COG2814	Major facilitator Superfamily
VPAR_RS01670	COG0360	Binds together with S18 to 16S ribosomal RNA
VPAR_RS01675	COG0629	single-stranded DNA binding
VPAR_RS01680	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
VPAR_RS01695	COG0535	radical SAM domain protein
VPAR_RS01695	COG1433	Dinitrogenase iron-molybdenum cofactor
VPAR_RS01700	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VPAR_RS01720	COG0220	tRNA (guanine-N7-)-methyltransferase activity
VPAR_RS01725	COG0772	Belongs to the SEDS family
VPAR_RS01770	COG2195	Cleaves the N-terminal amino acid of tripeptides
VPAR_RS01775	COG1297	OPT oligopeptide transporter protein
VPAR_RS01785	COG2040	homocysteine
VPAR_RS01795	COG0426	domain, Protein
VPAR_RS01800	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
VPAR_RS01805	COG0583	DNA-binding transcription factor activity
VPAR_RS01810	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
VPAR_RS01825	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
VPAR_RS01835	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
VPAR_RS01840	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
VPAR_RS01845	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
VPAR_RS01855	COG0151	Belongs to the GarS family
VPAR_RS01860	COG1169	isochorismate synthase
VPAR_RS01865	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
VPAR_RS01870	COG0596	Alpha beta hydrolase
VPAR_RS01875	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
VPAR_RS01880	COG0318	PFAM AMP-dependent synthetase and ligase
VPAR_RS01920	COG1396	sequence-specific DNA binding
VPAR_RS01955	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VPAR_RS01960	COG1649	PFAM Uncharacterised BCR, COG1649
VPAR_RS01960	COG0726	polysaccharide deacetylase
VPAR_RS01965	COG5434	Belongs to the glycosyl hydrolase 28 family
VPAR_RS01965	COG4632	Exopolysaccharide biosynthesis protein
VPAR_RS02000	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VPAR_RS02025	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
VPAR_RS02030	COG0284	orotidine-5'-phosphate decarboxylase activity
VPAR_RS02055	COG1464	Belongs to the NlpA lipoprotein family
VPAR_RS02060	COG1575	Belongs to the MenA family. Type 1 subfamily
VPAR_RS02075	COG0251	oxidation-reduction process
VPAR_RS02080	COG3681	Belongs to the UPF0597 family
VPAR_RS02085	COG2223	nitrite transmembrane transporter activity
VPAR_RS02115	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
VPAR_RS02120	COG2011	ABC-type metal ion transport system permease component
VPAR_RS02125	COG4496	protein, YerC YecD
VPAR_RS02135	COG1028	Short-chain dehydrogenase reductase Sdr
VPAR_RS02145	COG3339	Conserved Protein
VPAR_RS02150	COG0824	Thioesterase
VPAR_RS02155	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
VPAR_RS02170	COG0145	ligase activity
VPAR_RS02180	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
VPAR_RS02195	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
VPAR_RS02200	COG0281	malic enzyme
VPAR_RS02230	COG4974	Belongs to the 'phage' integrase family
VPAR_RS02255	COG1396	sequence-specific DNA binding
VPAR_RS02290	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
VPAR_RS02300	COG2022	thiamine diphosphate biosynthetic process
VPAR_RS02310	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VPAR_RS02315	COG0352	thiamine-phosphate diphosphorylase activity
VPAR_RS02320	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
VPAR_RS02325	COG1914	H( )-stimulated, divalent metal cation uptake system
VPAR_RS02330	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
VPAR_RS02335	COG1984	allophanate hydrolase subunit 2
VPAR_RS02345	COG0534	Mate efflux family protein
VPAR_RS02350	COG2885	chlorophyll binding
VPAR_RS02355	COG0628	permease
VPAR_RS02365	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VPAR_RS02370	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
VPAR_RS02375	COG2226	methyltransferase
VPAR_RS02410	COG0726	polysaccharide deacetylase
VPAR_RS02415	COG0521	Mo-molybdopterin cofactor biosynthetic process
VPAR_RS02420	COG1959	2 iron, 2 sulfur cluster binding
VPAR_RS02425	COG1271	oxidase subunit
VPAR_RS02430	COG1294	oxidase, subunit
VPAR_RS02435	COG4988	ABC transporter
VPAR_RS02455	COG0601	transmembrane transport
VPAR_RS02460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VPAR_RS02465	COG0444	Belongs to the ABC transporter superfamily
VPAR_RS02470	COG4608	Belongs to the ABC transporter superfamily
VPAR_RS02480	COG4166	transmembrane transport
VPAR_RS02485	COG1619	proteins homologs of microcin C7 resistance protein MccF
VPAR_RS02495	COG0488	(ABC) transporter
VPAR_RS02505	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
VPAR_RS02515	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VPAR_RS02515	COG0302	gtp cyclohydrolase
VPAR_RS02525	COG0039	L-malate dehydrogenase activity
VPAR_RS02535	COG1098	S1 RNA binding domain
VPAR_RS02545	COG0037	tRNA processing
VPAR_RS02555	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VPAR_RS02570	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
VPAR_RS02575	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VPAR_RS02580	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VPAR_RS02585	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
VPAR_RS02590	COG2252	PERMEase
VPAR_RS02595	COG0402	S-adenosylhomocysteine deaminase activity
VPAR_RS02610	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
VPAR_RS02615	COG1494	fructose-1,6-bisphosphatase
VPAR_RS02620	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
VPAR_RS02645	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
VPAR_RS02650	COG1127	ABC transporter
VPAR_RS02690	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VPAR_RS02695	COG1560	Kdo2-lipid A biosynthetic process
VPAR_RS02700	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
VPAR_RS02705	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VPAR_RS02710	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VPAR_RS02720	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VPAR_RS02725	COG1132	(ABC) transporter
VPAR_RS02730	COG1519	Transferase
VPAR_RS02735	COG1663	tetraacyldisaccharide 4'-kinase activity
VPAR_RS02740	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
VPAR_RS02745	COG2877	3-deoxy-8-phosphooctulonate synthase activity
VPAR_RS02755	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
VPAR_RS02770	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
VPAR_RS02775	COG1137	ATPase activity
VPAR_RS02785	COG4372	Transposase
VPAR_RS02795	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
VPAR_RS02805	COG0497	DNA recombination
VPAR_RS02810	COG0497	DNA recombination
VPAR_RS02815	COG0497	DNA recombination
VPAR_RS02825	COG1660	Displays ATPase and GTPase activities
VPAR_RS02830	COG0391	Required for morphogenesis under gluconeogenic growth conditions
VPAR_RS02835	COG1481	regulation of sporulation
VPAR_RS02845	COG0540	Belongs to the ATCase OTCase family
VPAR_RS02850	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
VPAR_RS02865	COG0543	2 iron, 2 sulfur cluster binding
VPAR_RS02870	COG0167	dihydroorotate dehydrogenase activity
VPAR_RS02875	COG0583	DNA-binding transcription factor activity
VPAR_RS02885	COG1739	Uncharacterized protein family UPF0029
VPAR_RS02890	COG2217	Heavy metal translocating P-type atpase
VPAR_RS02900	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VPAR_RS02905	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
VPAR_RS02910	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
VPAR_RS02930	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
VPAR_RS02935	COG0336	Belongs to the RNA methyltransferase TrmD family
VPAR_RS02970	COG4752	Belongs to the RNA methyltransferase TrmD family
VPAR_RS02975	COG0217	transcriptional regulatory protein
VPAR_RS02980	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
VPAR_RS02985	COG0632	four-way junction helicase activity
VPAR_RS02990	COG2255	four-way junction helicase activity
VPAR_RS02995	COG2247	cell wall binding repeat
VPAR_RS02995	COG2385	sporulation resulting in formation of a cellular spore
VPAR_RS03005	COG0343	queuine tRNA-ribosyltransferase activity
VPAR_RS03020	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VPAR_RS03025	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VPAR_RS03030	COG2814	Major facilitator Superfamily
VPAR_RS03050	COG3585	molybdate ion transport
VPAR_RS03065	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VPAR_RS03070	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VPAR_RS03075	COG3584	3D domain protein
VPAR_RS03075	COG3583	domain protein
VPAR_RS03080	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
VPAR_RS03085	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
VPAR_RS03095	COG0193	aminoacyl-tRNA hydrolase activity
VPAR_RS03100	COG1982	Orn Lys Arg decarboxylase major
VPAR_RS03105	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
VPAR_RS03110	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
VPAR_RS03115	COG1774	PSP1 C-terminal conserved region
VPAR_RS03120	COG2264	protein methyltransferase activity
VPAR_RS03125	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
VPAR_RS03130	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VPAR_RS03130	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VPAR_RS03135	COG0084	hydrolase, TatD family'
VPAR_RS03150	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
VPAR_RS03155	COG1388	LysM domain
VPAR_RS03155	COG3584	3D domain protein
VPAR_RS03165	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
VPAR_RS03170	COG0583	DNA-binding transcription factor activity
VPAR_RS03175	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
VPAR_RS03180	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
VPAR_RS03185	COG0786	glutamate:sodium symporter activity
VPAR_RS03190	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
VPAR_RS03195	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VPAR_RS03210	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
VPAR_RS03210	COG1918	ferrous iron import across plasma membrane
VPAR_RS03245	COG0820	rRNA (adenine-C2-)-methyltransferase activity
VPAR_RS03250	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
VPAR_RS03255	COG0298	carbon dioxide binding
VPAR_RS03295	COG1268	BioY protein
VPAR_RS03305	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VPAR_RS03315	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
VPAR_RS03320	COG3341	Caulimovirus viroplasmin
VPAR_RS03320	COG0328	RNA-DNA hybrid ribonuclease activity
VPAR_RS03325	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VPAR_RS03335	COG0166	Belongs to the GPI family
VPAR_RS03340	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VPAR_RS03355	COG0488	(ABC) transporter
VPAR_RS03380	COG0410	ABC transporter
VPAR_RS03400	COG0489	protein tyrosine kinase activity
VPAR_RS03400	COG3206	protein involved in exopolysaccharide biosynthesis
VPAR_RS03405	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
VPAR_RS03410	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VPAR_RS03415	COG3475	LICD family
VPAR_RS03420	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
VPAR_RS03425	COG1086	Polysaccharide biosynthesis protein
VPAR_RS03430	COG0438	transferase activity, transferring glycosyl groups
VPAR_RS03475	COG1328	CTP reductase activity
VPAR_RS03480	COG0602	queuosine metabolic process
VPAR_RS03500	COG1773	rubredoxin
VPAR_RS03510	COG0333	Belongs to the bacterial ribosomal protein bL32 family
VPAR_RS03520	COG0416	fatty acid biosynthetic process
VPAR_RS03525	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VPAR_RS03535	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
VPAR_RS03540	COG1028	Short-chain dehydrogenase reductase Sdr
VPAR_RS03545	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VPAR_RS03550	COG2070	2-Nitropropane dioxygenase
VPAR_RS03555	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VPAR_RS03560	COG0571	ribonuclease III activity
VPAR_RS03565	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VPAR_RS03570	COG1196	nuclear chromosome segregation
VPAR_RS03575	COG0552	protein localization to endoplasmic reticulum
VPAR_RS03585	COG0556	nucleotide-excision repair
VPAR_RS03590	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
VPAR_RS03595	COG0322	excinuclease ABC activity
VPAR_RS03600	COG0534	Mate efflux family protein
VPAR_RS03605	COG0861	Integral membrane protein TerC family
VPAR_RS03610	COG0861	Integral membrane protein TerC family
VPAR_RS03615	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VPAR_RS03635	COG4771	TonB-dependent receptor
VPAR_RS03645	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VPAR_RS03755	COG0179	Fumarylacetoacetate (FAA) hydrolase
VPAR_RS03760	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VPAR_RS03775	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VPAR_RS03785	COG0471	metal ion transport
VPAR_RS03790	COG1362	aminopeptidase activity
VPAR_RS03795	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
VPAR_RS03800	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
VPAR_RS03810	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VPAR_RS03815	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
VPAR_RS03815	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
VPAR_RS03820	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VPAR_RS03825	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VPAR_RS03830	COG0859	PFAM glycosyl transferase family 9
VPAR_RS03840	COG2176	DNA-directed DNA polymerase activity
VPAR_RS03845	COG1362	aminopeptidase activity
VPAR_RS03865	COG4120	Belongs to the binding-protein-dependent transport system permease family
VPAR_RS03875	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
VPAR_RS03880	COG1185	polyribonucleotide nucleotidyltransferase activity
VPAR_RS03885	COG0756	dUTP diphosphatase activity
VPAR_RS03890	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
VPAR_RS03890	COG4797	methyltransferase
VPAR_RS03905	COG2252	PERMEase
VPAR_RS03920	COG0268	Binds directly to 16S ribosomal RNA
VPAR_RS03930	COG0237	dephospho-CoA kinase activity
VPAR_RS03935	COG0741	lytic transglycosylase activity
VPAR_RS03945	COG0779	Required for maturation of 30S ribosomal subunits
VPAR_RS03950	COG0195	Participates in both transcription termination and antitermination
VPAR_RS03960	COG1358	cellular component organization or biogenesis
VPAR_RS03965	COG3170	Tfp pilus assembly protein FimV
VPAR_RS03965	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
VPAR_RS03970	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
VPAR_RS03975	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
VPAR_RS03985	COG0196	riboflavin kinase activity
VPAR_RS03995	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
VPAR_RS04000	COG1040	competence protein
VPAR_RS04010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VPAR_RS04015	COG0765	amino acid transport
VPAR_RS04025	COG1278	Cold shock
VPAR_RS04035	COG0653	protein targeting
VPAR_RS04040	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
VPAR_RS04060	COG3959	Transketolase, thiamine diphosphate binding domain
VPAR_RS04065	COG3958	Transketolase
VPAR_RS04070	COG2884	Cell division ATP-binding protein ftsE
VPAR_RS04075	COG2177	Part of the ABC transporter FtsEX involved in
VPAR_RS04080	COG0739	heme binding
VPAR_RS04085	COG0793	Belongs to the peptidase S41A family
VPAR_RS04090	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
VPAR_RS04100	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
VPAR_RS04105	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
VPAR_RS04110	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
VPAR_RS04115	COG1713	HD superfamily hydrolase involved in NAD metabolism
VPAR_RS04125	COG0799	negative regulation of ribosome biogenesis
VPAR_RS04130	COG2996	Protein conserved in bacteria
VPAR_RS04135	COG0569	domain protein
VPAR_RS04140	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VPAR_RS04145	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VPAR_RS04175	COG1683	Conserved Protein
VPAR_RS04190	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
VPAR_RS04195	COG1187	pseudouridine synthase activity
VPAR_RS04200	COG2081	HI0933 family
VPAR_RS04205	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
VPAR_RS04225	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
VPAR_RS04230	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
VPAR_RS04235	COG0742	ribosomal rna small subunit methyltransferase
VPAR_RS04240	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
VPAR_RS04250	COG1293	RNA-binding protein homologous to eukaryotic snRNP
VPAR_RS04255	COG1561	YicC-like family, N-terminal region
VPAR_RS04265	COG0194	GDP metabolic process
VPAR_RS04270	COG1758	RNA polymerase activity
VPAR_RS04275	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
VPAR_RS04280	COG0659	secondary active sulfate transmembrane transporter activity
VPAR_RS04285	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
VPAR_RS04290	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
VPAR_RS04295	COG0242	peptide deformylase activity
VPAR_RS04300	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
VPAR_RS04310	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VPAR_RS04310	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VPAR_RS04315	COG0820	rRNA (adenine-C2-)-methyltransferase activity
VPAR_RS04320	COG0631	protein serine/threonine phosphatase activity
VPAR_RS04325	COG2815	serine threonine protein kinase
VPAR_RS04325	COG0515	serine threonine protein kinase
VPAR_RS04330	COG1162	GTPase activity
VPAR_RS04335	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
VPAR_RS04340	COG0052	Belongs to the universal ribosomal protein uS2 family
VPAR_RS04345	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
VPAR_RS04350	COG0528	UMP kinase activity
VPAR_RS04355	COG0233	cytoplasmic translational termination
VPAR_RS04370	COG4589	Belongs to the CDS family
VPAR_RS04375	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
VPAR_RS04380	COG0750	zinc metalloprotease
VPAR_RS04385	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
VPAR_RS04390	COG0442	prolyl-tRNA aminoacylation
VPAR_RS04395	COG1796	DNA polymerase
VPAR_RS04395	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
VPAR_RS04405	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VPAR_RS04415	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
VPAR_RS04420	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
VPAR_RS04425	COG2521	methyltransferase
VPAR_RS04425	COG2136	Putative SAM-dependent methyltransferase
VPAR_RS04435	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
VPAR_RS04440	COG0482	sulfurtransferase activity
VPAR_RS04445	COG0481	GTPase activity
VPAR_RS04450	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VPAR_RS04465	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
VPAR_RS04470	COG0443	Heat shock 70 kDa protein
VPAR_RS04475	COG0484	heat shock protein binding
VPAR_RS04480	COG2264	protein methyltransferase activity
VPAR_RS04485	COG1385	rRNA (uridine-N3-)-methyltransferase activity
VPAR_RS04490	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VPAR_RS04495	COG0537	adenosine 5'-monophosphoramidase activity
VPAR_RS04500	COG0828	Belongs to the bacterial ribosomal protein bS21 family
VPAR_RS04505	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
VPAR_RS04510	COG0174	glutamine synthetase
VPAR_RS04520	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
VPAR_RS04525	COG1132	(ABC) transporter
VPAR_RS04530	COG1132	(ABC) transporter
VPAR_RS04535	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VPAR_RS04540	COG3394	polysaccharide catabolic process
VPAR_RS04550	COG4492	Belongs to the UPF0735 family
VPAR_RS04555	COG0460	homoserine dehydrogenase
VPAR_RS04560	COG0083	homoserine kinase activity
VPAR_RS04570	COG0105	UTP biosynthetic process
VPAR_RS04585	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
VPAR_RS04590	COG1492	cobalamin metabolic process
VPAR_RS04600	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
VPAR_RS04615	COG0406	alpha-ribazole phosphatase activity
VPAR_RS04620	COG1187	pseudouridine synthase activity
VPAR_RS04625	COG0006	proline dipeptidase activity
VPAR_RS04630	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VPAR_RS04645	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VPAR_RS04650	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
VPAR_RS04660	COG1722	exodeoxyribonuclease VII activity
VPAR_RS04675	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
VPAR_RS04680	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
VPAR_RS04690	COG1438	arginine binding
VPAR_RS04695	COG0497	DNA recombination
VPAR_RS04700	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
VPAR_RS04705	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VPAR_RS04710	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VPAR_RS04715	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
VPAR_RS04725	COG0385	Bile acid
VPAR_RS04730	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
VPAR_RS04745	COG2720	vancomycin resistance protein
VPAR_RS04785	COG0402	S-adenosylhomocysteine deaminase activity
VPAR_RS04790	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
VPAR_RS04795	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
VPAR_RS04800	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
VPAR_RS04805	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
VPAR_RS04815	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VPAR_RS04815	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VPAR_RS04825	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VPAR_RS04825	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VPAR_RS04830	COG0028	Belongs to the TPP enzyme family
VPAR_RS04860	COG1555	photosystem II stabilization
VPAR_RS04865	COG2309	aminopeptidase activity
VPAR_RS04875	COG0495	leucyl-tRNA aminoacylation
VPAR_RS04880	COG1388	LysM domain
VPAR_RS04880	COG3858	chitin binding
VPAR_RS04885	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
VPAR_RS04890	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
VPAR_RS04895	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VPAR_RS04900	COG0758	DNA mediated transformation
VPAR_RS04905	COG0606	chelatase, subunit chli
VPAR_RS04910	COG0792	nuclease activity
VPAR_RS04915	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
VPAR_RS04935	COG0751	glycine-tRNA ligase activity
VPAR_RS04940	COG0752	glycyl-tRNA synthetase alpha subunit
VPAR_RS04950	COG3210	domain, Protein
VPAR_RS04975	COG3875	lactate racemase activity
VPAR_RS04985	COG1691	(AIR) carboxylase
VPAR_RS05000	COG1253	flavin adenine dinucleotide binding
VPAR_RS05005	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
VPAR_RS05015	COG1702	phosphate starvation-inducible protein PhoH
VPAR_RS05020	COG1242	4 iron, 4 sulfur cluster binding
VPAR_RS05035	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
VPAR_RS05040	COG0154	amidase activity
VPAR_RS05050	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
VPAR_RS05055	COG0210	DNA helicase
VPAR_RS05060	COG1227	inorganic diphosphatase activity
VPAR_RS05085	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
VPAR_RS05095	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
VPAR_RS05100	COG0557	exoribonuclease II activity
VPAR_RS05105	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VPAR_RS05120	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VPAR_RS05125	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
VPAR_RS05130	COG0215	cysteine-tRNA ligase activity
VPAR_RS05135	COG0385	Bile acid
VPAR_RS05140	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VPAR_RS05145	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
VPAR_RS05145	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
VPAR_RS05150	COG4956	integral membrane protein (PIN domain superfamily)
VPAR_RS05155	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
VPAR_RS05160	COG0542	response to heat
VPAR_RS05165	COG3869	Catalyzes the specific phosphorylation of arginine residues in
VPAR_RS05170	COG3880	PFAM UvrB UvrC protein
VPAR_RS05175	COG4463	regulation of RNA biosynthetic process
VPAR_RS05190	COG0822	iron-sulfur transferase activity
VPAR_RS05195	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VPAR_RS05210	COG0396	ATPase activity
VPAR_RS05225	COG0459	protein refolding
VPAR_RS05230	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
VPAR_RS05250	COG0456	acetyltransferase
VPAR_RS05255	COG1214	PFAM Peptidase M22, glycoprotease
VPAR_RS05260	COG0802	atpase or kinase
VPAR_RS05265	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
VPAR_RS05275	COG0860	N-Acetylmuramoyl-L-alanine amidase
VPAR_RS05280	COG0658	competence protein
VPAR_RS05280	COG2333	competence protein COMEC
VPAR_RS05285	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
VPAR_RS05285	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
VPAR_RS05305	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
VPAR_RS05320	COG0688	phosphatidylethanolamine metabolic process
VPAR_RS05325	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
VPAR_RS05330	COG0517	IMP dehydrogenase activity
VPAR_RS05330	COG0516	GMP reductase activity
VPAR_RS05335	COG1942	4-Oxalocrotonate Tautomerase
VPAR_RS05340	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
VPAR_RS05345	COG0227	Belongs to the bacterial ribosomal protein bL28 family
VPAR_RS05350	COG0232	Belongs to the dGTPase family. Type 2 subfamily
VPAR_RS05355	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
VPAR_RS05360	COG0517	IMP dehydrogenase activity
VPAR_RS05365	COG0574	Belongs to the PEP-utilizing enzyme family
VPAR_RS05365	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
VPAR_RS05375	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VPAR_RS05380	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
VPAR_RS05385	COG1193	negative regulation of DNA recombination
VPAR_RS05390	COG0826	peptidase U32
VPAR_RS05395	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VPAR_RS05395	COG0072	phenylalanine-tRNA ligase activity
VPAR_RS05400	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
VPAR_RS05410	COG1136	(ABC) transporter
VPAR_RS05410	COG0577	efflux transmembrane transporter activity
VPAR_RS05415	COG1136	(ABC) transporter
VPAR_RS05420	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VPAR_RS05430	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
VPAR_RS05480	COG1459	type II secretion system
VPAR_RS05485	COG2805	Type II/IV secretion system protein
VPAR_RS05490	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VPAR_RS05505	COG0149	triose-phosphate isomerase activity
VPAR_RS05510	COG0126	phosphoglycerate kinase activity
VPAR_RS05530	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VPAR_RS05535	COG0698	ribose 5-phosphate isomerase
VPAR_RS05540	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VPAR_RS05545	COG0009	L-threonylcarbamoyladenylate synthase
VPAR_RS05550	COG2890	protein-(glutamine-N5) methyltransferase activity
VPAR_RS05560	COG3872	metal-dependent enzyme
VPAR_RS05565	COG0254	rRNA binding
VPAR_RS05580	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
VPAR_RS05585	COG4224	UPF0291 protein
VPAR_RS05600	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
VPAR_RS05620	COG1181	Belongs to the D-alanine--D-alanine ligase family
VPAR_RS05625	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VPAR_RS05635	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
VPAR_RS05640	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VPAR_RS05645	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
VPAR_RS05650	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
VPAR_RS05660	COG0275	rRNA processing
VPAR_RS05665	COG2001	Belongs to the MraZ family
VPAR_RS05670	COG3118	belongs to the thioredoxin family
VPAR_RS05680	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VPAR_RS05700	COG2033	superoxide reductase activity
VPAR_RS05720	COG4822	anaerobic cobalamin biosynthetic process
VPAR_RS05750	COG1120	ATPase activity
VPAR_RS05755	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VPAR_RS05795	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
VPAR_RS05800	COG1666	GTP binding
VPAR_RS05810	COG0564	pseudouridine synthase activity
VPAR_RS05815	COG0191	fructose-bisphosphate aldolase activity
VPAR_RS05820	COG2244	polysaccharide biosynthetic process
VPAR_RS05830	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
VPAR_RS05845	COG0546	phosphoglycolate phosphatase activity
VPAR_RS05895	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
VPAR_RS05900	COG0291	Belongs to the bacterial ribosomal protein bL35 family
VPAR_RS05905	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
VPAR_RS05910	COG0471	metal ion transport
VPAR_RS05915	COG2814	Major facilitator Superfamily
VPAR_RS05920	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
VPAR_RS05935	COG0826	peptidase U32
VPAR_RS05940	COG4122	O-methyltransferase activity
VPAR_RS05955	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
VPAR_RS05960	COG4472	Bacterial protein of unknown function (DUF965)
VPAR_RS05965	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
VPAR_RS05970	COG1388	LysM domain
VPAR_RS05970	COG0791	NLP P60 protein
VPAR_RS05975	COG0463	Glycosyl transferase, family 2
VPAR_RS05985	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
VPAR_RS06005	COG3118	belongs to the thioredoxin family
VPAR_RS06010	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
VPAR_RS06030	COG0602	queuosine metabolic process
VPAR_RS06040	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VPAR_RS06045	COG0358	DNA primase activity
VPAR_RS06050	COG1418	mRNA catabolic process
VPAR_RS06055	COG2137	regulation of response to DNA damage stimulus
VPAR_RS06060	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
VPAR_RS06065	COG1546	Belongs to the CinA family
VPAR_RS06065	COG1058	Belongs to the CinA family
VPAR_RS06085	COG1426	Protein conserved in bacteria
VPAR_RS06100	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
VPAR_RS06110	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VPAR_RS06115	COG0735	belongs to the Fur family
VPAR_RS06120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VPAR_RS06125	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VPAR_RS06130	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
VPAR_RS06130	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
VPAR_RS06135	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
VPAR_RS06140	COG0211	Belongs to the bacterial ribosomal protein bL27 family
VPAR_RS06150	COG0261	This protein binds to 23S rRNA in the presence of protein L20
VPAR_RS06155	COG1971	Probably functions as a manganese efflux pump
VPAR_RS06160	COG1530	ribonuclease E activity
VPAR_RS06175	COG0772	Belongs to the SEDS family
VPAR_RS06180	COG2894	cell division
VPAR_RS06185	COG0768	penicillin binding
VPAR_RS06200	COG1077	Cell shape determining protein MreB Mrl
VPAR_RS06205	COG2003	Belongs to the UPF0758 family
VPAR_RS06210	COG0424	maF-like protein
VPAR_RS06230	COG1323	Belongs to the UPF0348 family
VPAR_RS06235	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
VPAR_RS06240	COG0564	pseudouridine synthase activity
VPAR_RS06245	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
VPAR_RS06250	COG0490	domain, Protein
VPAR_RS06250	COG0471	metal ion transport
VPAR_RS06260	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
VPAR_RS06265	COG4770	biotin carboxylase activity
VPAR_RS06275	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
VPAR_RS06280	COG0346	lactoylglutathione lyase activity
VPAR_RS06290	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
VPAR_RS06290	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
VPAR_RS06295	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
VPAR_RS06295	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
VPAR_RS06300	COG0427	acetyl-CoA hydrolase
VPAR_RS06310	COG0285	dihydrofolate synthase activity
VPAR_RS06315	COG0525	valine-tRNA ligase activity
VPAR_RS06320	COG0805	protein transport
VPAR_RS06330	COG0218	Necessary for normal cell division and for the maintenance of normal septation
VPAR_RS06335	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
VPAR_RS06340	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
VPAR_RS06345	COG0740	serine-type endopeptidase activity
VPAR_RS06350	COG0544	peptidyl-prolyl cis-trans isomerase activity
VPAR_RS06355	COG0516	GMP reductase activity
VPAR_RS06355	COG0517	IMP dehydrogenase activity
VPAR_RS06360	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
VPAR_RS06365	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
VPAR_RS06370	COG1850	ribulose-bisphosphate carboxylase activity
VPAR_RS06375	COG2233	PERMEase
VPAR_RS06390	COG0493	'glutamate synthase
VPAR_RS06390	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VPAR_RS06395	COG0402	S-adenosylhomocysteine deaminase activity
VPAR_RS06400	COG0549	Belongs to the carbamate kinase family
VPAR_RS06405	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
VPAR_RS06410	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VPAR_RS06450	COG1970	mechanosensitive ion channel activity
VPAR_RS06455	COG3593	DNA synthesis involved in DNA repair
VPAR_RS06470	COG2837	iron assimilation
VPAR_RS06485	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
VPAR_RS06495	COG2233	PERMEase
VPAR_RS06500	COG3404	Formiminotransferase-cyclodeaminase
VPAR_RS06510	COG3273	potassium ion transport
VPAR_RS06510	COG0471	metal ion transport
VPAR_RS06515	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
VPAR_RS06520	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
VPAR_RS06525	COG2207	Transcriptional regulator
VPAR_RS06535	COG2207	Transcriptional regulator
VPAR_RS06540	COG0542	response to heat
VPAR_RS06560	COG3859	Proton-coupled thiamine transporter YuaJ
VPAR_RS06565	COG0516	GMP reductase activity
VPAR_RS06570	COG2223	nitrite transmembrane transporter activity
VPAR_RS06585	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
VPAR_RS06590	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VPAR_RS06595	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
VPAR_RS06605	COG1473	amidohydrolase
VPAR_RS06615	COG0288	reversible hydration of carbon dioxide
VPAR_RS06620	COG0440	acetolactate synthase activity
VPAR_RS06625	COG0028	Belongs to the TPP enzyme family
VPAR_RS06635	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
VPAR_RS06650	COG1704	LemA family
VPAR_RS06685	COG1217	gtp-binding protein TYPA
VPAR_RS06700	COG3679	Belongs to the UPF0342 family
VPAR_RS06705	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
VPAR_RS06710	COG0315	cyclic pyranopterin monophosphate synthase activity
VPAR_RS06715	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
VPAR_RS06735	COG0569	domain protein
VPAR_RS06740	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VPAR_RS06745	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VPAR_RS06765	COG0848	biopolymer transport protein
VPAR_RS06770	COG0811	peptide transport
VPAR_RS06775	COG4771	TonB-dependent receptor
VPAR_RS06780	COG4771	TonB-dependent receptor
VPAR_RS06780	COG4771	TonB-dependent receptor
VPAR_RS06785	COG2207	Transcriptional regulator
VPAR_RS06785	COG0662	Cupin 2, conserved barrel domain protein
VPAR_RS06810	COG4139	cobalamin transport
VPAR_RS06815	COG1120	ATPase activity
VPAR_RS06825	COG0306	phosphate transporter
VPAR_RS06840	COG0488	(ABC) transporter
VPAR_RS06850	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
VPAR_RS06855	COG0776	regulation of translation
VPAR_RS06860	COG3956	TIGRFAM MazG family protein
VPAR_RS06865	COG2244	polysaccharide biosynthetic process
VPAR_RS06870	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
VPAR_RS06880	COG0842	Transport permease protein
VPAR_RS06885	COG0842	Transport permease protein
VPAR_RS06890	COG1131	(ABC) transporter
VPAR_RS06960	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
VPAR_RS06970	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VPAR_RS06975	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
VPAR_RS06985	COG0419	ATPase involved in DNA repair
VPAR_RS06995	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
VPAR_RS07000	COG0735	belongs to the Fur family
VPAR_RS07005	COG0513	Belongs to the DEAD box helicase family
VPAR_RS07020	COG3048	D-serine ammonia-lyase activity
VPAR_RS07025	COG1012	belongs to the aldehyde dehydrogenase family
VPAR_RS07030	COG2183	response to ionizing radiation
VPAR_RS07035	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
VPAR_RS07040	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
VPAR_RS07045	COG0514	ATP-dependent DNA helicase (RecQ)
VPAR_RS07050	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VPAR_RS07060	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
VPAR_RS07060	COG4797	methyltransferase
VPAR_RS07070	COG0583	DNA-binding transcription factor activity
VPAR_RS07115	COG2301	Belongs to the HpcH HpaI aldolase family
VPAR_RS07120	COG3052	prosthetic group binding
VPAR_RS07125	COG0471	metal ion transport
VPAR_RS07130	COG0583	DNA-binding transcription factor activity
VPAR_RS07135	COG0670	Belongs to the BI1 family
VPAR_RS07170	COG3210	domain, Protein
VPAR_RS07215	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
VPAR_RS07220	COG0113	porphobilinogen synthase activity
VPAR_RS07225	COG1587	Uroporphyrinogen-III synthase
VPAR_RS07225	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VPAR_RS07235	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
VPAR_RS07240	COG1648	precorrin-2 dehydrogenase activity
VPAR_RS07240	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VPAR_RS07245	COG2302	S4 RNA-binding domain
VPAR_RS07250	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
VPAR_RS07255	COG1799	cell septum assembly
VPAR_RS07270	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VPAR_RS07285	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
VPAR_RS07290	COG1119	ATPase activity
VPAR_RS07300	COG0028	Belongs to the TPP enzyme family
VPAR_RS07305	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
VPAR_RS07310	COG0129	dihydroxy-acid dehydratase activity
VPAR_RS07315	COG0471	metal ion transport
VPAR_RS07320	COG0662	Cupin 2, conserved barrel domain protein
VPAR_RS07330	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VPAR_RS07335	COG0363	glucosamine-6-phosphate deaminase activity
VPAR_RS07340	COG1024	Enoyl-CoA hydratase
VPAR_RS07345	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
VPAR_RS07350	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
VPAR_RS07365	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
VPAR_RS07370	COG0583	DNA-binding transcription factor activity
VPAR_RS07375	COG1742	UPF0060 membrane protein
VPAR_RS07425	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
VPAR_RS07430	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
VPAR_RS07440	COG0534	Mate efflux family protein
VPAR_RS07445	COG1013	pyruvate-flavodoxin oxidoreductase activity
VPAR_RS07450	COG0674	pyruvate-flavodoxin oxidoreductase activity
VPAR_RS07450	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
VPAR_RS07460	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
VPAR_RS07470	COG1122	ATPase activity
VPAR_RS07475	COG0203	ribosomal protein L17
VPAR_RS07480	COG0202	RNA polymerase activity
VPAR_RS07490	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
VPAR_RS07495	COG0257	Belongs to the bacterial ribosomal protein bL36 family
VPAR_RS07515	COG0201	protein transport
VPAR_RS07520	COG0200	Binds to the 23S rRNA
VPAR_RS07525	COG1841	ribosomal large subunit assembly
VPAR_RS07530	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
VPAR_RS07535	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
VPAR_RS07545	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
VPAR_RS07555	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
VPAR_RS07565	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
VPAR_RS07575	COG0255	Belongs to the universal ribosomal protein uL29 family
VPAR_RS07580	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
VPAR_RS07585	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
VPAR_RS07590	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
VPAR_RS07595	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
VPAR_RS07600	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
VPAR_RS07610	COG0088	Forms part of the polypeptide exit tunnel
VPAR_RS07615	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
VPAR_RS07620	COG0051	transcription antitermination factor activity, RNA binding
VPAR_RS07625	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VPAR_RS07635	COG0049	tRNA binding
VPAR_RS07640	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
VPAR_RS07650	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VPAR_RS07655	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
VPAR_RS07660	COG0085	RNA polymerase activity
VPAR_RS07665	COG1027	Aspartate ammonia-lyase
VPAR_RS07670	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
VPAR_RS07675	COG0222	ribosome binding
VPAR_RS07685	COG0081	regulation of translation
VPAR_RS07690	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
VPAR_RS07695	COG0250	Participates in transcription elongation, termination and antitermination
VPAR_RS07700	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VPAR_RS07705	COG0267	Belongs to the bacterial ribosomal protein bL33 family
VPAR_RS07715	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VPAR_RS07755	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
VPAR_RS07765	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
VPAR_RS07770	COG0768	penicillin binding
VPAR_RS07775	COG0617	tRNA 3'-terminal CCA addition
VPAR_RS07780	COG1760	l-serine dehydratase
VPAR_RS07785	COG1760	l-serine dehydratase
VPAR_RS07790	COG1151	hydroxylamine reductase activity
VPAR_RS07840	COG0355	proton-transporting ATP synthase activity, rotational mechanism
VPAR_RS07855	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
VPAR_RS07860	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
VPAR_RS07865	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
VPAR_RS07870	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
VPAR_RS07875	COG0356	it plays a direct role in the translocation of protons across the membrane
VPAR_RS07890	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
VPAR_RS07895	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VPAR_RS07900	COG2848	UPF0210 protein
VPAR_RS07905	COG3830	Belongs to the UPF0237 family
VPAR_RS07910	COG0033	Phosphoglucomutase
VPAR_RS07915	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
VPAR_RS07920	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
VPAR_RS07925	COG1802	Transcriptional regulator
VPAR_RS07930	COG1115	amino acid carrier protein
VPAR_RS07935	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
VPAR_RS07945	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
VPAR_RS07950	COG0708	Exodeoxyribonuclease III
VPAR_RS07965	COG0494	nUDIX hydrolase
VPAR_RS07980	COG0747	negative chemotaxis
VPAR_RS07990	COG0444	Belongs to the ABC transporter superfamily
VPAR_RS07995	COG0747	negative chemotaxis
VPAR_RS08000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VPAR_RS08010	COG0531	amino acid
VPAR_RS08015	COG0165	Argininosuccinate lyase
VPAR_RS08020	COG0137	argininosuccinate synthase activity
VPAR_RS08050	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
VPAR_RS08055	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
VPAR_RS08060	COG1757	Na H antiporter
VPAR_RS08065	COG1105	Belongs to the carbohydrate kinase PfkB family
VPAR_RS08070	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VPAR_RS08070	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VPAR_RS08070	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VPAR_RS08100	COG0450	alkyl hydroperoxide reductase
VPAR_RS08110	COG0504	CTP synthase activity
VPAR_RS08115	COG0018	arginyl-trna synthetase
VPAR_RS08140	COG0561	phosphatase activity
VPAR_RS08150	COG0371	Dehydrogenase
VPAR_RS08155	COG1114	Component of the transport system for branched-chain amino acids
VPAR_RS08160	COG0243	molybdopterin cofactor binding
VPAR_RS08165	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
VPAR_RS08170	COG1620	l-lactate permease
VPAR_RS08180	COG2814	Major facilitator Superfamily
VPAR_RS08200	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
VPAR_RS08210	COG1454	alcohol dehydrogenase
VPAR_RS08220	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VPAR_RS08225	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VPAR_RS08240	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
VPAR_RS08245	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
VPAR_RS08250	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
VPAR_RS08255	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
VPAR_RS08260	COG1605	Chorismate mutase
VPAR_RS08260	COG0077	Prephenate dehydratase
VPAR_RS08280	COG0710	3-dehydroquinate dehydratase activity
VPAR_RS08285	COG2814	Major facilitator Superfamily
VPAR_RS08290	COG1959	2 iron, 2 sulfur cluster binding
VPAR_RS08295	COG2252	PERMEase
VPAR_RS08325	COG1113	amino acid transport
VPAR_RS08345	COG0564	pseudouridine synthase activity
VPAR_RS08360	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
VPAR_RS08365	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
VPAR_RS08370	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
VPAR_RS08375	COG0070	glutamate synthase
VPAR_RS08375	COG0069	glutamate synthase activity
VPAR_RS08375	COG0067	glutamate synthase
VPAR_RS08380	COG0564	pseudouridine synthase activity
VPAR_RS08400	COG0656	L-ascorbic acid biosynthetic process
VPAR_RS08405	COG1687	branched-chain amino acid
VPAR_RS08410	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
VPAR_RS08415	COG1979	alcohol dehydrogenase
VPAR_RS08430	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VPAR_RS08430	COG2146	nitrite reductase [NAD(P)H] activity
VPAR_RS08440	COG1556	Lactate utilization protein
VPAR_RS08445	COG1139	Iron-sulfur cluster binding protein
VPAR_RS08450	COG0247	lactate metabolic process
VPAR_RS08460	COG1361	Conserved repeat domain
VPAR_RS08460	COG3266	domain, Protein
VPAR_RS08460	COG2911	Protein conserved in bacteria
VPAR_RS08470	COG1297	OPT oligopeptide transporter protein
VPAR_RS08480	COG1408	metallophosphoesterase
VPAR_RS08510	COG1196	nuclear chromosome segregation
VPAR_RS08520	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
VPAR_RS08535	COG1597	lipid kinase activity
VPAR_RS08540	COG1074	ATP-dependent DNA helicase activity
VPAR_RS08545	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
VPAR_RS08575	COG2217	Heavy metal translocating P-type atpase
VPAR_RS08580	COG1174	glycine betaine transport
VPAR_RS08590	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
VPAR_RS08600	COG0305	Participates in initiation and elongation during chromosome replication
VPAR_RS08605	COG0359	binds to the 23S rRNA
VPAR_RS08610	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
VPAR_RS08620	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
VPAR_RS08635	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VPAR_RS08635	COG1116	anion transmembrane transporter activity
VPAR_RS08640	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VPAR_RS08645	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VPAR_RS08650	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
VPAR_RS08655	COG0586	Pfam SNARE associated Golgi protein
VPAR_RS08660	COG1120	ATPase activity
VPAR_RS08665	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VPAR_RS08675	COG4771	TonB-dependent receptor
VPAR_RS08685	COG0848	biopolymer transport protein
VPAR_RS08690	COG0811	peptide transport
VPAR_RS08705	COG0515	serine threonine protein kinase
VPAR_RS08710	COG2048	Heterodisulfide reductase, subunit B
VPAR_RS08715	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
VPAR_RS08720	COG1053	succinate dehydrogenase
VPAR_RS08725	COG0745	RESPONSE REGULATOR receiver
VPAR_RS08730	COG0642	Histidine kinase
VPAR_RS08735	COG2733	membrane
VPAR_RS08740	COG2733	membrane
VPAR_RS08750	COG1733	regulation of RNA biosynthetic process
VPAR_RS08755	COG3384	dioxygenase
VPAR_RS08760	COG0386	Belongs to the glutathione peroxidase family
VPAR_RS08775	COG0280	phosphate acetyltransferase
VPAR_RS08790	COG0493	'glutamate synthase
VPAR_RS08795	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
VPAR_RS08805	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
VPAR_RS08815	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
VPAR_RS08825	COG2824	Alkylphosphonate utilization operon protein PhnA
VPAR_RS08840	COG0789	Transcriptional regulator
VPAR_RS08855	COG2249	NAD(P)H dehydrogenase (quinone) activity
VPAR_RS08890	COG4268	DNA restriction-modification system
VPAR_RS08895	COG1401	restriction endodeoxyribonuclease activity
VPAR_RS08920	COG0753	catalase activity
VPAR_RS08930	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
VPAR_RS08940	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
VPAR_RS08945	COG1396	sequence-specific DNA binding
VPAR_RS08945	COG1917	Cupin 2, conserved barrel domain protein
VPAR_RS08960	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
VPAR_RS08975	COG0848	biopolymer transport protein
VPAR_RS08980	COG0811	peptide transport
VPAR_RS08995	COG1703	isobutyryl-CoA mutase activity
VPAR_RS09000	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
VPAR_RS09000	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
VPAR_RS09005	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
VPAR_RS09005	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
VPAR_RS09010	COG2962	Rard protein
VPAR_RS09035	COG0277	FAD linked oxidase domain protein
VPAR_RS09055	COG1454	alcohol dehydrogenase
VPAR_RS09085	COG1846	Transcriptional regulator
VPAR_RS09100	COG2217	Heavy metal translocating P-type atpase
VPAR_RS09105	COG2271	Major facilitator Superfamily
VPAR_RS09115	COG1393	Belongs to the ArsC family
VPAR_RS09125	COG3549	Plasmid maintenance system killer
VPAR_RS09135	COG0519	Catalyzes the synthesis of GMP from XMP
VPAR_RS09190	COG1332	CRISPR-associated RAMP protein, Csm5 family
VPAR_RS09195	COG1567	CRISPR-associated RAMP protein, Csm4 family
VPAR_RS09200	COG1337	RAMP superfamily
VPAR_RS09210	COG1353	crispr-associated protein
VPAR_RS09325	COG1472	Belongs to the glycosyl hydrolase 3 family
VPAR_RS09345	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
VPAR_RS09355	COG1489	DNA binding
VPAR_RS09360	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VPAR_RS09395	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
VPAR_RS09400	COG0739	heme binding
VPAR_RS09400	COG1196	nuclear chromosome segregation
VPAR_RS09400	COG0741	lytic transglycosylase activity
VPAR_RS09410	COG1160	GTP binding
VPAR_RS09415	COG1475	DNA binding
VPAR_RS09420	COG1192	Involved in chromosome partitioning
VPAR_RS09430	COG0646	methionine synthase
VPAR_RS09430	COG1410	methionine synthase
VPAR_RS09435	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
VPAR_RS09435	COG0646	methionine synthase
VPAR_RS09440	COG0357	Ribosomal RNA small subunit methyltransferase G
VPAR_RS09445	COG0445	tRNA wobble uridine modification
VPAR_RS09450	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
VPAR_RS09455	COG1847	R3H domain protein
VPAR_RS09460	COG0706	membrane insertase activity
VPAR_RS09465	COG0594	ribonuclease P activity
VPAR_RS09470	COG0230	Belongs to the bacterial ribosomal protein bL34 family