locus-tag	class	description
B1A77_RS00070	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
B1A77_RS00080	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
B1A77_RS00085	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
B1A77_RS00095	COG0419	ATPase involved in DNA repair
B1A77_RS00105	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
B1A77_RS00110	COG0735	belongs to the Fur family
B1A77_RS00115	COG0513	Belongs to the DEAD box helicase family
B1A77_RS00135	COG3048	D-serine ammonia-lyase activity
B1A77_RS00140	COG1012	belongs to the aldehyde dehydrogenase family
B1A77_RS00145	COG2183	response to ionizing radiation
B1A77_RS00150	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
B1A77_RS00155	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
B1A77_RS00160	COG0514	ATP-dependent DNA helicase (RecQ)
B1A77_RS00165	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B1A77_RS00175	COG4797	methyltransferase
B1A77_RS00175	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B1A77_RS00185	COG0583	DNA-binding transcription factor activity
B1A77_RS00230	COG2301	Belongs to the HpcH HpaI aldolase family
B1A77_RS00235	COG3052	prosthetic group binding
B1A77_RS00240	COG0471	metal ion transport
B1A77_RS00245	COG0583	DNA-binding transcription factor activity
B1A77_RS00250	COG0670	Belongs to the BI1 family
B1A77_RS00310	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B1A77_RS00315	COG0113	porphobilinogen synthase activity
B1A77_RS00320	COG1587	Uroporphyrinogen-III synthase
B1A77_RS00320	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B1A77_RS00330	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
B1A77_RS00335	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B1A77_RS00335	COG1648	precorrin-2 dehydrogenase activity
B1A77_RS00340	COG2302	S4 RNA-binding domain
B1A77_RS00345	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B1A77_RS00350	COG1799	cell septum assembly
B1A77_RS00365	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B1A77_RS00380	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
B1A77_RS00385	COG1119	ATPase activity
B1A77_RS00395	COG0028	Belongs to the TPP enzyme family
B1A77_RS00400	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B1A77_RS00405	COG0129	dihydroxy-acid dehydratase activity
B1A77_RS00410	COG0471	metal ion transport
B1A77_RS00415	COG0662	Cupin 2, conserved barrel domain protein
B1A77_RS00425	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B1A77_RS00430	COG0363	glucosamine-6-phosphate deaminase activity
B1A77_RS00435	COG1024	Enoyl-CoA hydratase
B1A77_RS00440	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B1A77_RS00445	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
B1A77_RS00450	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
B1A77_RS00455	COG0583	DNA-binding transcription factor activity
B1A77_RS00460	COG1742	UPF0060 membrane protein
B1A77_RS00510	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
B1A77_RS00515	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
B1A77_RS00520	COG0287	Prephenate dehydrogenase
B1A77_RS00525	COG0534	Mate efflux family protein
B1A77_RS00530	COG1013	pyruvate-flavodoxin oxidoreductase activity
B1A77_RS00535	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
B1A77_RS00535	COG0674	pyruvate-flavodoxin oxidoreductase activity
B1A77_RS00545	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
B1A77_RS00555	COG1122	ATPase activity
B1A77_RS00560	COG0203	ribosomal protein L17
B1A77_RS00565	COG0202	RNA polymerase activity
B1A77_RS00575	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
B1A77_RS00580	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B1A77_RS00600	COG0201	protein transport
B1A77_RS00605	COG0200	Binds to the 23S rRNA
B1A77_RS00610	COG1841	ribosomal large subunit assembly
B1A77_RS00615	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
B1A77_RS00620	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
B1A77_RS00630	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
B1A77_RS00640	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
B1A77_RS00650	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
B1A77_RS00655	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
B1A77_RS00660	COG0255	Belongs to the universal ribosomal protein uL29 family
B1A77_RS00665	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
B1A77_RS00670	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
B1A77_RS00675	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
B1A77_RS00680	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
B1A77_RS00685	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
B1A77_RS00695	COG0088	Forms part of the polypeptide exit tunnel
B1A77_RS00700	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
B1A77_RS00705	COG0051	transcription antitermination factor activity, RNA binding
B1A77_RS00710	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B1A77_RS00720	COG0049	tRNA binding
B1A77_RS00725	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
B1A77_RS00735	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B1A77_RS00740	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B1A77_RS00745	COG0085	RNA polymerase activity
B1A77_RS00750	COG1027	Aspartate ammonia-lyase
B1A77_RS00755	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
B1A77_RS00760	COG0222	ribosome binding
B1A77_RS00770	COG0081	regulation of translation
B1A77_RS00775	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
B1A77_RS00780	COG0250	Participates in transcription elongation, termination and antitermination
B1A77_RS00785	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B1A77_RS00790	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B1A77_RS00800	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B1A77_RS00840	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
B1A77_RS00850	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B1A77_RS00855	COG0768	penicillin binding
B1A77_RS00860	COG0617	tRNA 3'-terminal CCA addition
B1A77_RS00865	COG1760	l-serine dehydratase
B1A77_RS00870	COG1760	l-serine dehydratase
B1A77_RS00875	COG1151	hydroxylamine reductase activity
B1A77_RS00925	COG0355	proton-transporting ATP synthase activity, rotational mechanism
B1A77_RS00940	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
B1A77_RS00945	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B1A77_RS00950	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
B1A77_RS00955	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B1A77_RS00960	COG0356	it plays a direct role in the translocation of protons across the membrane
B1A77_RS00975	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
B1A77_RS00980	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B1A77_RS00985	COG2848	UPF0210 protein
B1A77_RS00990	COG3830	Belongs to the UPF0237 family
B1A77_RS00995	COG0033	Phosphoglucomutase
B1A77_RS01000	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B1A77_RS01010	COG1802	Transcriptional regulator
B1A77_RS01015	COG1115	amino acid carrier protein
B1A77_RS01020	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B1A77_RS01030	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
B1A77_RS01035	COG0708	Exodeoxyribonuclease III
B1A77_RS01065	COG0747	negative chemotaxis
B1A77_RS01075	COG0444	Belongs to the ABC transporter superfamily
B1A77_RS01080	COG0747	negative chemotaxis
B1A77_RS01085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B1A77_RS01090	COG0601	transmembrane transport
B1A77_RS01095	COG0531	amino acid
B1A77_RS01100	COG0165	Argininosuccinate lyase
B1A77_RS01105	COG0137	argininosuccinate synthase activity
B1A77_RS01125	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B1A77_RS01130	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
B1A77_RS01135	COG1757	Na H antiporter
B1A77_RS01140	COG1105	Belongs to the carbohydrate kinase PfkB family
B1A77_RS01145	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B1A77_RS01145	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B1A77_RS01145	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B1A77_RS01165	COG0450	alkyl hydroperoxide reductase
B1A77_RS01170	COG0504	CTP synthase activity
B1A77_RS01175	COG0018	arginyl-trna synthetase
B1A77_RS01200	COG0561	phosphatase activity
B1A77_RS01210	COG0371	Dehydrogenase
B1A77_RS01215	COG1114	Component of the transport system for branched-chain amino acids
B1A77_RS01220	COG0243	molybdopterin cofactor binding
B1A77_RS01225	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
B1A77_RS01230	COG1620	l-lactate permease
B1A77_RS01240	COG2814	Major facilitator Superfamily
B1A77_RS01260	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
B1A77_RS01280	COG1454	alcohol dehydrogenase
B1A77_RS01290	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B1A77_RS01295	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B1A77_RS01310	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
B1A77_RS01315	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
B1A77_RS01320	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B1A77_RS01325	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
B1A77_RS01330	COG1605	Chorismate mutase
B1A77_RS01330	COG0077	Prephenate dehydratase
B1A77_RS01350	COG0710	3-dehydroquinate dehydratase activity
B1A77_RS01355	COG2814	Major facilitator Superfamily
B1A77_RS01360	COG1959	2 iron, 2 sulfur cluster binding
B1A77_RS01365	COG2252	PERMEase
B1A77_RS01395	COG1113	amino acid transport
B1A77_RS01415	COG0564	pseudouridine synthase activity
B1A77_RS01430	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
B1A77_RS01435	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
B1A77_RS01440	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
B1A77_RS01460	COG0069	glutamate synthase activity
B1A77_RS01460	COG0067	glutamate synthase
B1A77_RS01460	COG0070	glutamate synthase
B1A77_RS01465	COG0564	pseudouridine synthase activity
B1A77_RS01485	COG0656	L-ascorbic acid biosynthetic process
B1A77_RS01490	COG1687	branched-chain amino acid
B1A77_RS01495	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
B1A77_RS01500	COG1979	alcohol dehydrogenase
B1A77_RS01555	COG0791	NLP P60 protein
B1A77_RS01760	COG2146	nitrite reductase [NAD(P)H] activity
B1A77_RS01760	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B1A77_RS01770	COG1556	Lactate utilization protein
B1A77_RS01775	COG1139	Iron-sulfur cluster binding protein
B1A77_RS01780	COG0247	lactate metabolic process
B1A77_RS01790	COG3266	domain, Protein
B1A77_RS01790	COG2911	Protein conserved in bacteria
B1A77_RS01790	COG1361	Conserved repeat domain
B1A77_RS01800	COG1297	OPT oligopeptide transporter protein
B1A77_RS01865	COG1408	metallophosphoesterase
B1A77_RS01895	COG1196	nuclear chromosome segregation
B1A77_RS01905	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B1A77_RS01920	COG1597	lipid kinase activity
B1A77_RS01925	COG1074	ATP-dependent DNA helicase activity
B1A77_RS01930	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
B1A77_RS01950	COG3645	SOS response
B1A77_RS01970	COG2217	Heavy metal translocating P-type atpase
B1A77_RS01975	COG1174	glycine betaine transport
B1A77_RS01985	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B1A77_RS01995	COG0305	Participates in initiation and elongation during chromosome replication
B1A77_RS02000	COG0359	binds to the 23S rRNA
B1A77_RS02005	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
B1A77_RS02015	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
B1A77_RS02030	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B1A77_RS02030	COG1116	anion transmembrane transporter activity
B1A77_RS02035	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B1A77_RS02040	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B1A77_RS02045	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
B1A77_RS02050	COG0586	Pfam SNARE associated Golgi protein
B1A77_RS02055	COG1120	ATPase activity
B1A77_RS02060	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B1A77_RS02070	COG4771	TonB-dependent receptor
B1A77_RS02080	COG0848	biopolymer transport protein
B1A77_RS02100	COG0515	serine threonine protein kinase
B1A77_RS02105	COG2048	Heterodisulfide reductase, subunit B
B1A77_RS02110	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B1A77_RS02115	COG1053	succinate dehydrogenase
B1A77_RS02120	COG0745	RESPONSE REGULATOR receiver
B1A77_RS02125	COG0642	Histidine kinase
B1A77_RS02130	COG2733	membrane
B1A77_RS02135	COG2733	membrane
B1A77_RS02145	COG1733	regulation of RNA biosynthetic process
B1A77_RS02150	COG3384	dioxygenase
B1A77_RS02170	COG0280	phosphate acetyltransferase
B1A77_RS02185	COG0493	'glutamate synthase
B1A77_RS02190	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
B1A77_RS02200	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B1A77_RS02210	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
B1A77_RS02220	COG2824	Alkylphosphonate utilization operon protein PhnA
B1A77_RS02225	COG0789	Transcriptional regulator
B1A77_RS02240	COG2249	NAD(P)H dehydrogenase (quinone) activity
B1A77_RS02305	COG1401	restriction endodeoxyribonuclease activity
B1A77_RS02335	COG0753	catalase activity
B1A77_RS02345	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B1A77_RS02355	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
B1A77_RS02365	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
B1A77_RS02380	COG0848	biopolymer transport protein
B1A77_RS02385	COG0811	peptide transport
B1A77_RS02395	COG1703	isobutyryl-CoA mutase activity
B1A77_RS02400	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B1A77_RS02400	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B1A77_RS02405	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B1A77_RS02405	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B1A77_RS02410	COG2962	Rard protein
B1A77_RS02440	COG0277	FAD linked oxidase domain protein
B1A77_RS02460	COG1454	alcohol dehydrogenase
B1A77_RS02490	COG1846	Transcriptional regulator
B1A77_RS02505	COG2271	Major facilitator Superfamily
B1A77_RS02515	COG1393	Belongs to the ArsC family
B1A77_RS02530	COG0519	Catalyzes the synthesis of GMP from XMP
B1A77_RS02705	COG1472	Belongs to the glycosyl hydrolase 3 family
B1A77_RS02725	COG0477	Major facilitator Superfamily
B1A77_RS02735	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B1A77_RS02750	COG1489	DNA binding
B1A77_RS02755	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B1A77_RS02790	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
B1A77_RS02795	COG0739	heme binding
B1A77_RS02795	COG0741	lytic transglycosylase activity
B1A77_RS02795	COG1196	nuclear chromosome segregation
B1A77_RS02805	COG1160	GTP binding
B1A77_RS02815	COG1475	DNA binding
B1A77_RS02820	COG1192	Involved in chromosome partitioning
B1A77_RS02830	COG0646	methionine synthase
B1A77_RS02830	COG1410	methionine synthase
B1A77_RS02835	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
B1A77_RS02835	COG0646	methionine synthase
B1A77_RS02845	COG0445	tRNA wobble uridine modification
B1A77_RS02850	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
B1A77_RS02855	COG1847	R3H domain protein
B1A77_RS02860	COG0706	membrane insertase activity
B1A77_RS02865	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
B1A77_RS02870	COG0594	ribonuclease P activity
B1A77_RS02875	COG0230	Belongs to the bacterial ribosomal protein bL34 family
B1A77_RS02880	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
B1A77_RS02895	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B1A77_RS02910	COG0187	DNA topoisomerase II activity
B1A77_RS02915	COG0833	amino acid
B1A77_RS02930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B1A77_RS02935	COG1253	flavin adenine dinucleotide binding
B1A77_RS02965	COG0438	transferase activity, transferring glycosyl groups
B1A77_RS02985	COG0562	UDP-galactopyranose mutase
B1A77_RS03000	COG0438	transferase activity, transferring glycosyl groups
B1A77_RS03005	COG0726	polysaccharide deacetylase
B1A77_RS03010	COG3475	LICD family
B1A77_RS03015	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
B1A77_RS03025	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B1A77_RS03130	COG0811	peptide transport
B1A77_RS03135	COG0848	biopolymer transport protein
B1A77_RS03155	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B1A77_RS03160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B1A77_RS03165	COG1120	ATPase activity
B1A77_RS03190	COG4206	TonB-dependent receptor
B1A77_RS03195	COG0436	Aminotransferase
B1A77_RS03200	COG0640	Transcriptional regulator
B1A77_RS03210	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
B1A77_RS03225	COG4221	oxidoreductase activity
B1A77_RS03245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B1A77_RS03250	COG0747	negative chemotaxis
B1A77_RS03285	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
B1A77_RS03315	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B1A77_RS03320	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B1A77_RS03325	COG0066	3-isopropylmalate dehydratase activity
B1A77_RS03330	COG0473	3-isopropylmalate dehydrogenase activity
B1A77_RS03345	COG1196	nuclear chromosome segregation
B1A77_RS03370	COG0435	Glutathione S-transferase
B1A77_RS03380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B1A77_RS03385	COG0765	amino acid transport
B1A77_RS03390	COG0765	amino acid transport
B1A77_RS03395	COG1126	abc transporter atp-binding protein
B1A77_RS03410	COG1879	ABC-type sugar transport system periplasmic component
B1A77_RS03415	COG1172	Belongs to the binding-protein-dependent transport system permease family
B1A77_RS03420	COG1129	ABC transporter
B1A77_RS03425	COG1869	D-ribose catabolic process
B1A77_RS03430	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B1A77_RS03470	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
B1A77_RS03475	COG1122	ATPase activity
B1A77_RS03480	COG1122	ATPase activity
B1A77_RS03495	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
B1A77_RS03505	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
B1A77_RS03510	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
B1A77_RS03515	COG0131	Imidazoleglycerol-phosphate dehydratase
B1A77_RS03520	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
B1A77_RS03525	COG0107	imidazoleglycerol-phosphate synthase activity
B1A77_RS03530	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
B1A77_RS03540	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B1A77_RS03545	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
B1A77_RS03550	COG1966	Carbon starvation protein
B1A77_RS03590	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
B1A77_RS03600	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B1A77_RS03605	COG1045	serine acetyltransferase
B1A77_RS03610	COG0783	Belongs to the Dps family
B1A77_RS03625	COG1914	H( )-stimulated, divalent metal cation uptake system
B1A77_RS03640	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
B1A77_RS03645	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B1A77_RS03650	COG2731	YhcH YjgK YiaL family protein
B1A77_RS03655	COG0697	spore germination
B1A77_RS03670	COG3069	C4-dicarboxylate transmembrane transporter activity
B1A77_RS03695	COG0512	Glutamine amidotransferase of anthranilate synthase
B1A77_RS03695	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B1A77_RS03700	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B1A77_RS03705	COG0134	indole-3-glycerol-phosphate synthase activity
B1A77_RS03710	COG0133	tryptophan synthase activity
B1A77_RS03715	COG0159	tryptophan synthase activity
B1A77_RS03760	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
B1A77_RS03770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B1A77_RS03780	COG0561	phosphatase activity
B1A77_RS03790	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B1A77_RS03790	COG0519	Catalyzes the synthesis of GMP from XMP
B1A77_RS03830	COG0357	Ribosomal RNA small subunit methyltransferase G
B1A77_RS03840	COG0456	acetyltransferase
B1A77_RS03855	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B1A77_RS03860	COG1120	ATPase activity
B1A77_RS03865	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B1A77_RS03870	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B1A77_RS03875	COG1121	(ABC) transporter
B1A77_RS03880	COG0803	Belongs to the bacterial solute-binding protein 9 family
B1A77_RS03905	COG0583	DNA-binding transcription factor activity
B1A77_RS03920	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
B1A77_RS03925	COG0420	3'-5' exonuclease activity
B1A77_RS03930	COG4717	serine-type aminopeptidase activity
B1A77_RS03935	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
B1A77_RS03940	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
B1A77_RS03945	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
B1A77_RS03950	COG3253	May function as heme-dependent peroxidase
B1A77_RS03955	COG2223	nitrite transmembrane transporter activity
B1A77_RS03960	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B1A77_RS03965	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
B1A77_RS03970	COG1140	nitrate reductase beta subunit
B1A77_RS03975	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
B1A77_RS03980	COG2181	nitrate reductase activity
B1A77_RS03990	COG3206	protein involved in exopolysaccharide biosynthesis
B1A77_RS04005	COG0583	DNA-binding transcription factor activity
B1A77_RS04015	COG2855	membrane
B1A77_RS04020	COG0288	reversible hydration of carbon dioxide
B1A77_RS04030	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B1A77_RS04035	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
B1A77_RS04045	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B1A77_RS04050	COG1121	(ABC) transporter
B1A77_RS04055	COG0803	Belongs to the bacterial solute-binding protein 9 family
B1A77_RS04095	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B1A77_RS04100	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B1A77_RS04105	COG1309	transcriptional regulator
B1A77_RS04110	COG2217	Heavy metal translocating P-type atpase
B1A77_RS04115	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
B1A77_RS04120	COG1882	Formate acetyltransferase
B1A77_RS04145	COG2011	ABC-type metal ion transport system permease component
B1A77_RS04165	COG0471	metal ion transport
B1A77_RS04180	COG0626	cystathionine gamma-synthase activity
B1A77_RS04185	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
B1A77_RS04190	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
B1A77_RS04195	COG2873	o-acetylhomoserine
B1A77_RS04215	COG0701	Predicted permease
B1A77_RS04220	COG0523	cobalamin synthesis protein
B1A77_RS04225	COG2195	Cleaves the N-terminal amino acid of tripeptides
B1A77_RS04230	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
B1A77_RS04240	COG0252	asparaginase activity
B1A77_RS04250	COG0668	transmembrane transport
B1A77_RS04255	COG1686	Belongs to the peptidase S11 family
B1A77_RS04265	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
B1A77_RS04275	COG2080	2 iron, 2 sulfur cluster binding
B1A77_RS04280	COG2080	2 iron, 2 sulfur cluster binding
B1A77_RS04280	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B1A77_RS04300	COG3608	succinylglutamate desuccinylase aspartoacylase
B1A77_RS04300	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
B1A77_RS04310	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
B1A77_RS04315	COG4856	YbbR-like protein
B1A77_RS04320	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
B1A77_RS04325	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B1A77_RS04340	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B1A77_RS04345	COG0180	Tryptophanyl-tRNA synthetase
B1A77_RS04360	COG0765	amino acid transport
B1A77_RS04365	COG1126	abc transporter atp-binding protein
B1A77_RS04375	COG0589	response to stress
B1A77_RS04380	COG0640	Transcriptional regulator
B1A77_RS04395	COG0725	ABC transporter, periplasmic molybdate-binding protein
B1A77_RS04400	COG4149	molybdate abc transporter
B1A77_RS04405	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
B1A77_RS04430	COG1592	Rubrerythrin
B1A77_RS04440	COG0709	Synthesizes selenophosphate from selenide and ATP
B1A77_RS04455	COG0778	Nitroreductase
B1A77_RS04460	COG2261	transglycosylase associated protein
B1A77_RS04470	COG0012	GTP binding
B1A77_RS04475	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B1A77_RS04490	COG0436	Aminotransferase
B1A77_RS04495	COG2814	Major facilitator Superfamily
B1A77_RS04500	COG0360	Binds together with S18 to 16S ribosomal RNA
B1A77_RS04505	COG0629	single-stranded DNA binding
B1A77_RS04510	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
B1A77_RS04525	COG0535	radical SAM domain protein
B1A77_RS04525	COG1433	Dinitrogenase iron-molybdenum cofactor
B1A77_RS04530	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B1A77_RS04555	COG0220	tRNA (guanine-N7-)-methyltransferase activity
B1A77_RS04560	COG0772	Belongs to the SEDS family
B1A77_RS04605	COG2195	Cleaves the N-terminal amino acid of tripeptides
B1A77_RS04610	COG1297	OPT oligopeptide transporter protein
B1A77_RS04620	COG2040	homocysteine
B1A77_RS04630	COG0426	domain, Protein
B1A77_RS04635	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B1A77_RS04640	COG0583	DNA-binding transcription factor activity
B1A77_RS04645	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B1A77_RS04660	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
B1A77_RS04670	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
B1A77_RS04675	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
B1A77_RS04680	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
B1A77_RS04685	COG0138	bifunctional purine biosynthesis protein purh
B1A77_RS04690	COG0151	Belongs to the GarS family
B1A77_RS04695	COG1169	isochorismate synthase
B1A77_RS04700	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
B1A77_RS04705	COG0596	Alpha beta hydrolase
B1A77_RS04710	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
B1A77_RS04715	COG0318	PFAM AMP-dependent synthetase and ligase
B1A77_RS04720	COG4948	Mandelate Racemase Muconate Lactonizing
B1A77_RS04750	COG0582	viral genome integration into host DNA
B1A77_RS04825	COG0629	single-stranded DNA binding
B1A77_RS04840	COG3617	BRO family, N-terminal domain
B1A77_RS04910	COG0740	serine-type endopeptidase activity
B1A77_RS05050	COG3645	SOS response
B1A77_RS05105	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B1A77_RS05115	COG0726	polysaccharide deacetylase
B1A77_RS05115	COG1649	PFAM Uncharacterised BCR, COG1649
B1A77_RS05120	COG4632	Exopolysaccharide biosynthesis protein
B1A77_RS05120	COG5434	Belongs to the glycosyl hydrolase 28 family
B1A77_RS05130	COG0859	PFAM glycosyl transferase family 9
B1A77_RS05155	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B1A77_RS05175	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
B1A77_RS05180	COG0284	orotidine-5'-phosphate decarboxylase activity
B1A77_RS05205	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
B1A77_RS05210	COG0671	phosphoesterase, PA-phosphatase related
B1A77_RS05215	COG5002	protein histidine kinase activity
B1A77_RS05220	COG0745	RESPONSE REGULATOR receiver
B1A77_RS05225	COG1464	Belongs to the NlpA lipoprotein family
B1A77_RS05230	COG1575	Belongs to the MenA family. Type 1 subfamily
B1A77_RS05245	COG0251	oxidation-reduction process
B1A77_RS05250	COG3681	Belongs to the UPF0597 family
B1A77_RS05255	COG2223	nitrite transmembrane transporter activity
B1A77_RS05265	COG0590	tRNA wobble adenosine to inosine editing
B1A77_RS05290	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B1A77_RS05295	COG2011	ABC-type metal ion transport system permease component
B1A77_RS05300	COG4496	protein, YerC YecD
B1A77_RS05310	COG1028	Short-chain dehydrogenase reductase Sdr
B1A77_RS05320	COG3339	Conserved Protein
B1A77_RS05325	COG0824	Thioesterase
B1A77_RS05330	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
B1A77_RS05345	COG0145	ligase activity
B1A77_RS05355	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
B1A77_RS05370	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
B1A77_RS05375	COG0281	malic enzyme
B1A77_RS05435	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
B1A77_RS05445	COG2022	thiamine diphosphate biosynthetic process
B1A77_RS05455	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B1A77_RS05460	COG0352	thiamine-phosphate diphosphorylase activity
B1A77_RS05465	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
B1A77_RS05470	COG1914	H( )-stimulated, divalent metal cation uptake system
B1A77_RS05475	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
B1A77_RS05480	COG1984	allophanate hydrolase subunit 2
B1A77_RS05495	COG0534	Mate efflux family protein
B1A77_RS05500	COG2885	chlorophyll binding
B1A77_RS05505	COG0628	permease
B1A77_RS05515	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B1A77_RS05520	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
B1A77_RS05525	COG2226	methyltransferase
B1A77_RS05560	COG0726	polysaccharide deacetylase
B1A77_RS05565	COG0521	Mo-molybdopterin cofactor biosynthetic process
B1A77_RS05570	COG1959	2 iron, 2 sulfur cluster binding
B1A77_RS05575	COG1271	oxidase subunit
B1A77_RS05580	COG1294	oxidase, subunit
B1A77_RS05585	COG4988	ABC transporter
B1A77_RS05605	COG0601	transmembrane transport
B1A77_RS05610	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B1A77_RS05615	COG0444	Belongs to the ABC transporter superfamily
B1A77_RS05620	COG4608	Belongs to the ABC transporter superfamily
B1A77_RS05630	COG4166	transmembrane transport
B1A77_RS05635	COG1619	proteins homologs of microcin C7 resistance protein MccF
B1A77_RS05645	COG0488	(ABC) transporter
B1A77_RS05655	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
B1A77_RS05665	COG0302	gtp cyclohydrolase
B1A77_RS05665	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
B1A77_RS05675	COG0039	L-malate dehydrogenase activity
B1A77_RS05685	COG1098	S1 RNA binding domain
B1A77_RS05695	COG0037	tRNA processing
B1A77_RS05705	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B1A77_RS05720	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
B1A77_RS05725	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B1A77_RS05730	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B1A77_RS05735	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B1A77_RS05740	COG1982	Orn Lys Arg decarboxylase major
B1A77_RS05745	COG0531	amino acid
B1A77_RS05750	COG2252	PERMEase
B1A77_RS05755	COG0402	S-adenosylhomocysteine deaminase activity
B1A77_RS05770	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B1A77_RS05775	COG1494	fructose-1,6-bisphosphatase
B1A77_RS05780	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B1A77_RS05805	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
B1A77_RS05810	COG1127	ABC transporter
B1A77_RS05850	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B1A77_RS05855	COG1560	Kdo2-lipid A biosynthetic process
B1A77_RS05860	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
B1A77_RS05865	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B1A77_RS05870	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B1A77_RS05880	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B1A77_RS05885	COG1132	(ABC) transporter
B1A77_RS05890	COG1519	Transferase
B1A77_RS05895	COG1663	tetraacyldisaccharide 4'-kinase activity
B1A77_RS05900	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
B1A77_RS05905	COG2877	3-deoxy-8-phosphooctulonate synthase activity
B1A77_RS05915	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
B1A77_RS05930	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
B1A77_RS05935	COG1137	ATPase activity
B1A77_RS05945	COG4372	Transposase
B1A77_RS05955	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B1A77_RS05965	COG0497	DNA recombination
B1A77_RS05970	COG0497	DNA recombination
B1A77_RS05985	COG0391	Required for morphogenesis under gluconeogenic growth conditions
B1A77_RS05990	COG1481	regulation of sporulation
B1A77_RS06000	COG0540	Belongs to the ATCase OTCase family
B1A77_RS06005	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B1A77_RS06020	COG0543	2 iron, 2 sulfur cluster binding
B1A77_RS06025	COG0167	dihydroorotate dehydrogenase activity
B1A77_RS06030	COG0583	DNA-binding transcription factor activity
B1A77_RS06040	COG1739	Uncharacterized protein family UPF0029
B1A77_RS06045	COG2217	Heavy metal translocating P-type atpase
B1A77_RS06055	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B1A77_RS06060	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
B1A77_RS06065	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B1A77_RS06085	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
B1A77_RS06090	COG0336	Belongs to the RNA methyltransferase TrmD family
B1A77_RS06125	COG4752	Belongs to the RNA methyltransferase TrmD family
B1A77_RS06135	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
B1A77_RS06140	COG0632	four-way junction helicase activity
B1A77_RS06145	COG2255	four-way junction helicase activity
B1A77_RS06150	COG2247	cell wall binding repeat
B1A77_RS06150	COG2385	sporulation resulting in formation of a cellular spore
B1A77_RS06160	COG0343	queuine tRNA-ribosyltransferase activity
B1A77_RS06175	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B1A77_RS06180	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B1A77_RS06185	COG2814	Major facilitator Superfamily
B1A77_RS06205	COG3585	molybdate ion transport
B1A77_RS06220	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
B1A77_RS06225	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
B1A77_RS06230	COG3584	3D domain protein
B1A77_RS06230	COG3583	domain protein
B1A77_RS06235	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B1A77_RS06240	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B1A77_RS06250	COG0193	aminoacyl-tRNA hydrolase activity
B1A77_RS06255	COG1982	Orn Lys Arg decarboxylase major
B1A77_RS06260	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B1A77_RS06265	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
B1A77_RS06270	COG1774	PSP1 C-terminal conserved region
B1A77_RS06275	COG2264	protein methyltransferase activity
B1A77_RS06280	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
B1A77_RS06285	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B1A77_RS06285	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B1A77_RS06290	COG0084	hydrolase, TatD family'
B1A77_RS06305	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
B1A77_RS06310	COG3584	3D domain protein
B1A77_RS06310	COG1388	LysM domain
B1A77_RS06315	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B1A77_RS06315	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B1A77_RS06320	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
B1A77_RS06325	COG0583	DNA-binding transcription factor activity
B1A77_RS06330	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
B1A77_RS06335	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B1A77_RS06340	COG0786	glutamate:sodium symporter activity
B1A77_RS06345	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
B1A77_RS06350	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B1A77_RS06365	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
B1A77_RS06365	COG1918	ferrous iron import across plasma membrane
B1A77_RS06405	COG0820	rRNA (adenine-C2-)-methyltransferase activity
B1A77_RS06415	COG0298	carbon dioxide binding
B1A77_RS06455	COG1268	BioY protein
B1A77_RS06465	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B1A77_RS06475	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
B1A77_RS06480	COG0328	RNA-DNA hybrid ribonuclease activity
B1A77_RS06480	COG3341	Caulimovirus viroplasmin
B1A77_RS06485	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B1A77_RS06495	COG0166	Belongs to the GPI family
B1A77_RS06500	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B1A77_RS06515	COG0488	(ABC) transporter
B1A77_RS06565	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B1A77_RS06570	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B1A77_RS06575	COG3475	LICD family
B1A77_RS06580	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
B1A77_RS06585	COG1086	Polysaccharide biosynthesis protein
B1A77_RS06590	COG0438	transferase activity, transferring glycosyl groups
B1A77_RS06635	COG1328	CTP reductase activity
B1A77_RS06640	COG0602	queuosine metabolic process
B1A77_RS06665	COG1773	rubredoxin
B1A77_RS06675	COG0333	Belongs to the bacterial ribosomal protein bL32 family
B1A77_RS06685	COG0416	fatty acid biosynthetic process
B1A77_RS06690	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B1A77_RS06700	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
B1A77_RS06705	COG1028	Short-chain dehydrogenase reductase Sdr
B1A77_RS06710	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B1A77_RS06715	COG2070	2-Nitropropane dioxygenase
B1A77_RS06720	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B1A77_RS06725	COG0571	ribonuclease III activity
B1A77_RS06730	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B1A77_RS06735	COG1196	nuclear chromosome segregation
B1A77_RS06740	COG0552	protein localization to endoplasmic reticulum
B1A77_RS06750	COG0556	nucleotide-excision repair
B1A77_RS06755	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B1A77_RS06760	COG0322	excinuclease ABC activity
B1A77_RS06765	COG0534	Mate efflux family protein
B1A77_RS06770	COG0861	Integral membrane protein TerC family
B1A77_RS06775	COG0861	Integral membrane protein TerC family
B1A77_RS06780	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B1A77_RS06865	COG0179	Fumarylacetoacetate (FAA) hydrolase
B1A77_RS06870	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B1A77_RS06885	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B1A77_RS06895	COG0471	metal ion transport
B1A77_RS06900	COG1362	aminopeptidase activity
B1A77_RS06905	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
B1A77_RS06910	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
B1A77_RS06920	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
B1A77_RS06925	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
B1A77_RS06925	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
B1A77_RS06930	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B1A77_RS06935	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
B1A77_RS06940	COG0859	PFAM glycosyl transferase family 9
B1A77_RS06950	COG2176	DNA-directed DNA polymerase activity
B1A77_RS06955	COG1362	aminopeptidase activity
B1A77_RS06975	COG4120	Belongs to the binding-protein-dependent transport system permease family
B1A77_RS06985	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
B1A77_RS06990	COG1185	polyribonucleotide nucleotidyltransferase activity
B1A77_RS06995	COG0756	dUTP diphosphatase activity
B1A77_RS07020	COG4797	methyltransferase
B1A77_RS07020	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B1A77_RS07035	COG2252	PERMEase
B1A77_RS07050	COG0268	Binds directly to 16S ribosomal RNA
B1A77_RS07060	COG0237	dephospho-CoA kinase activity
B1A77_RS07065	COG0741	lytic transglycosylase activity
B1A77_RS07075	COG0779	Required for maturation of 30S ribosomal subunits
B1A77_RS07080	COG0195	Participates in both transcription termination and antitermination
B1A77_RS07090	COG1358	cellular component organization or biogenesis
B1A77_RS07095	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
B1A77_RS07095	COG3170	Tfp pilus assembly protein FimV
B1A77_RS07100	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
B1A77_RS07115	COG0196	riboflavin kinase activity
B1A77_RS07125	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B1A77_RS07130	COG1040	competence protein
B1A77_RS07140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B1A77_RS07145	COG0765	amino acid transport
B1A77_RS07155	COG1278	Cold shock
B1A77_RS07165	COG0653	protein targeting
B1A77_RS07170	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
B1A77_RS07190	COG3959	Transketolase, thiamine diphosphate binding domain
B1A77_RS07195	COG3958	Transketolase
B1A77_RS07200	COG2884	Cell division ATP-binding protein ftsE
B1A77_RS07205	COG2177	Part of the ABC transporter FtsEX involved in
B1A77_RS07210	COG0739	heme binding
B1A77_RS07215	COG0793	Belongs to the peptidase S41A family
B1A77_RS07220	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B1A77_RS07230	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
B1A77_RS07235	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
B1A77_RS07240	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
B1A77_RS07245	COG1713	HD superfamily hydrolase involved in NAD metabolism
B1A77_RS07255	COG0799	negative regulation of ribosome biogenesis
B1A77_RS07260	COG2996	Protein conserved in bacteria
B1A77_RS07265	COG0569	domain protein
B1A77_RS07270	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B1A77_RS07275	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B1A77_RS07305	COG1683	Conserved Protein
B1A77_RS07320	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
B1A77_RS07325	COG1187	pseudouridine synthase activity
B1A77_RS07330	COG2081	HI0933 family
B1A77_RS07345	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
B1A77_RS07345	COG0539	negative regulation of cytoplasmic translation
B1A77_RS07350	COG1160	GTP binding
B1A77_RS07355	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
B1A77_RS07360	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
B1A77_RS07365	COG0742	ribosomal rna small subunit methyltransferase
B1A77_RS07370	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
B1A77_RS07380	COG1293	RNA-binding protein homologous to eukaryotic snRNP
B1A77_RS07385	COG1561	YicC-like family, N-terminal region
B1A77_RS07395	COG0194	GDP metabolic process
B1A77_RS07400	COG1758	RNA polymerase activity
B1A77_RS07405	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B1A77_RS07410	COG0659	secondary active sulfate transmembrane transporter activity
B1A77_RS07415	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
B1A77_RS07420	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
B1A77_RS07425	COG0242	peptide deformylase activity
B1A77_RS07430	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B1A77_RS07440	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B1A77_RS07440	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B1A77_RS07445	COG0820	rRNA (adenine-C2-)-methyltransferase activity
B1A77_RS07450	COG0631	protein serine/threonine phosphatase activity
B1A77_RS07455	COG0515	serine threonine protein kinase
B1A77_RS07455	COG2815	serine threonine protein kinase
B1A77_RS07460	COG1162	GTPase activity
B1A77_RS07465	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
B1A77_RS07470	COG0052	Belongs to the universal ribosomal protein uS2 family
B1A77_RS07475	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
B1A77_RS07480	COG0528	UMP kinase activity
B1A77_RS07485	COG0233	cytoplasmic translational termination
B1A77_RS07500	COG4589	Belongs to the CDS family
B1A77_RS07505	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
B1A77_RS07510	COG0750	zinc metalloprotease
B1A77_RS07515	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
B1A77_RS07520	COG0442	prolyl-tRNA aminoacylation
B1A77_RS07535	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B1A77_RS07545	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
B1A77_RS07550	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
B1A77_RS07555	COG2521	methyltransferase
B1A77_RS07555	COG2136	Putative SAM-dependent methyltransferase
B1A77_RS07565	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
B1A77_RS07570	COG0482	sulfurtransferase activity
B1A77_RS07575	COG0481	GTPase activity
B1A77_RS07580	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B1A77_RS07595	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
B1A77_RS07600	COG0443	Heat shock 70 kDa protein
B1A77_RS07605	COG0484	heat shock protein binding
B1A77_RS07610	COG2264	protein methyltransferase activity
B1A77_RS07615	COG1385	rRNA (uridine-N3-)-methyltransferase activity
B1A77_RS07620	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B1A77_RS07625	COG0537	adenosine 5'-monophosphoramidase activity
B1A77_RS07630	COG0828	Belongs to the bacterial ribosomal protein bS21 family
B1A77_RS07635	COG1610	YqeY-like protein
B1A77_RS07640	COG0174	glutamine synthetase
B1A77_RS07650	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
B1A77_RS07655	COG1132	(ABC) transporter
B1A77_RS07660	COG1132	(ABC) transporter
B1A77_RS07665	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B1A77_RS07670	COG3394	polysaccharide catabolic process
B1A77_RS07680	COG4492	Belongs to the UPF0735 family
B1A77_RS07685	COG0460	homoserine dehydrogenase
B1A77_RS07690	COG0083	homoserine kinase activity
B1A77_RS07700	COG0105	UTP biosynthetic process
B1A77_RS07715	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
B1A77_RS07720	COG1492	cobalamin metabolic process
B1A77_RS07730	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
B1A77_RS07745	COG0406	alpha-ribazole phosphatase activity
B1A77_RS07750	COG1187	pseudouridine synthase activity
B1A77_RS07755	COG0006	proline dipeptidase activity
B1A77_RS07760	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B1A77_RS07775	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B1A77_RS07780	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B1A77_RS07785	COG1570	exodeoxyribonuclease VII activity
B1A77_RS07790	COG1722	exodeoxyribonuclease VII activity
B1A77_RS07805	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
B1A77_RS07810	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B1A77_RS07820	COG1438	arginine binding
B1A77_RS07825	COG0497	DNA recombination
B1A77_RS07830	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
B1A77_RS07835	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
B1A77_RS07840	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B1A77_RS07845	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
B1A77_RS07855	COG0385	Bile acid
B1A77_RS07860	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B1A77_RS07875	COG2720	vancomycin resistance protein
B1A77_RS07900	COG2226	methyltransferase
B1A77_RS07905	COG0402	S-adenosylhomocysteine deaminase activity
B1A77_RS07910	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
B1A77_RS07915	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
B1A77_RS07920	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
B1A77_RS07925	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
B1A77_RS07935	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B1A77_RS07935	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B1A77_RS07945	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B1A77_RS07945	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B1A77_RS07950	COG0028	Belongs to the TPP enzyme family
B1A77_RS07985	COG2309	aminopeptidase activity
B1A77_RS07995	COG0495	leucyl-tRNA aminoacylation
B1A77_RS08000	COG3858	chitin binding
B1A77_RS08000	COG1388	LysM domain
B1A77_RS08005	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
B1A77_RS08010	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
B1A77_RS08015	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B1A77_RS08020	COG0758	DNA mediated transformation
B1A77_RS08030	COG0792	nuclease activity
B1A77_RS08035	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B1A77_RS08055	COG0751	glycine-tRNA ligase activity
B1A77_RS08060	COG0752	glycyl-tRNA synthetase alpha subunit
B1A77_RS08075	COG3210	domain, Protein
B1A77_RS08110	COG1253	flavin adenine dinucleotide binding
B1A77_RS08115	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
B1A77_RS08125	COG1702	phosphate starvation-inducible protein PhoH
B1A77_RS08130	COG1242	4 iron, 4 sulfur cluster binding
B1A77_RS08145	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B1A77_RS08150	COG0154	amidase activity
B1A77_RS08160	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B1A77_RS08165	COG0210	DNA helicase
B1A77_RS08170	COG1227	inorganic diphosphatase activity
B1A77_RS08200	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
B1A77_RS08210	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
B1A77_RS08215	COG0557	exoribonuclease II activity
B1A77_RS08220	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B1A77_RS08235	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B1A77_RS08240	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
B1A77_RS08245	COG0215	cysteine-tRNA ligase activity
B1A77_RS08250	COG0385	Bile acid
B1A77_RS08255	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B1A77_RS08260	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
B1A77_RS08260	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
B1A77_RS08265	COG4956	integral membrane protein (PIN domain superfamily)
B1A77_RS08270	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
B1A77_RS08275	COG0542	response to heat
B1A77_RS08280	COG3869	Catalyzes the specific phosphorylation of arginine residues in
B1A77_RS08285	COG3880	PFAM UvrB UvrC protein
B1A77_RS08290	COG4463	regulation of RNA biosynthetic process
B1A77_RS08305	COG0822	iron-sulfur transferase activity
B1A77_RS08310	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B1A77_RS08325	COG0396	ATPase activity
B1A77_RS08340	COG0459	protein refolding
B1A77_RS08345	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
B1A77_RS08365	COG0456	acetyltransferase
B1A77_RS08370	COG1214	PFAM Peptidase M22, glycoprotease
B1A77_RS08375	COG0802	atpase or kinase
B1A77_RS08380	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
B1A77_RS08390	COG0860	N-Acetylmuramoyl-L-alanine amidase
B1A77_RS08395	COG0658	competence protein
B1A77_RS08395	COG2333	competence protein COMEC
B1A77_RS08400	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
B1A77_RS08400	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
B1A77_RS08420	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
B1A77_RS08435	COG0688	phosphatidylethanolamine metabolic process
B1A77_RS08440	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
B1A77_RS08445	COG0517	IMP dehydrogenase activity
B1A77_RS08445	COG0516	GMP reductase activity
B1A77_RS08450	COG1942	4-Oxalocrotonate Tautomerase
B1A77_RS08455	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
B1A77_RS08460	COG0227	Belongs to the bacterial ribosomal protein bL28 family
B1A77_RS08465	COG0232	Belongs to the dGTPase family. Type 2 subfamily
B1A77_RS08470	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
B1A77_RS08475	COG0517	IMP dehydrogenase activity
B1A77_RS08480	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B1A77_RS08480	COG0574	Belongs to the PEP-utilizing enzyme family
B1A77_RS08490	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B1A77_RS08495	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
B1A77_RS08500	COG1193	negative regulation of DNA recombination
B1A77_RS08505	COG0826	peptidase U32
B1A77_RS08510	COG0072	phenylalanine-tRNA ligase activity
B1A77_RS08510	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B1A77_RS08515	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
B1A77_RS08530	COG1136	(ABC) transporter
B1A77_RS08535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B1A77_RS08545	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
B1A77_RS08595	COG1459	type II secretion system
B1A77_RS08600	COG2805	Type II/IV secretion system protein
B1A77_RS08605	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B1A77_RS08615	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
B1A77_RS08620	COG0149	triose-phosphate isomerase activity
B1A77_RS08625	COG0126	phosphoglycerate kinase activity
B1A77_RS08650	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B1A77_RS08655	COG0698	ribose 5-phosphate isomerase
B1A77_RS08660	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B1A77_RS08665	COG0009	L-threonylcarbamoyladenylate synthase
B1A77_RS08670	COG2890	protein-(glutamine-N5) methyltransferase activity
B1A77_RS08680	COG3872	metal-dependent enzyme
B1A77_RS08685	COG0254	rRNA binding
B1A77_RS08700	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
B1A77_RS08705	COG4224	UPF0291 protein
B1A77_RS08720	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
B1A77_RS08740	COG1181	Belongs to the D-alanine--D-alanine ligase family
B1A77_RS08745	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B1A77_RS08755	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B1A77_RS08760	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B1A77_RS08765	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B1A77_RS08770	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B1A77_RS08780	COG0275	rRNA processing
B1A77_RS08785	COG2001	Belongs to the MraZ family
B1A77_RS08790	COG3118	belongs to the thioredoxin family
B1A77_RS08800	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B1A77_RS08820	COG2033	superoxide reductase activity
B1A77_RS08840	COG4822	anaerobic cobalamin biosynthetic process
B1A77_RS08880	COG1120	ATPase activity
B1A77_RS08885	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B1A77_RS08925	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
B1A77_RS08930	COG1666	GTP binding
B1A77_RS08940	COG0564	pseudouridine synthase activity
B1A77_RS08945	COG0191	fructose-bisphosphate aldolase activity
B1A77_RS08950	COG2244	polysaccharide biosynthetic process
B1A77_RS08960	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
B1A77_RS08980	COG0546	phosphoglycolate phosphatase activity
B1A77_RS09005	COG1401	restriction endodeoxyribonuclease activity
B1A77_RS09015	COG1401	restriction endodeoxyribonuclease activity
B1A77_RS09055	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
B1A77_RS09060	COG0291	Belongs to the bacterial ribosomal protein bL35 family
B1A77_RS09065	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
B1A77_RS09070	COG0471	metal ion transport
B1A77_RS09075	COG2814	Major facilitator Superfamily
B1A77_RS09080	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B1A77_RS09095	COG0826	peptidase U32
B1A77_RS09100	COG4122	O-methyltransferase activity
B1A77_RS09115	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
B1A77_RS09120	COG4472	Bacterial protein of unknown function (DUF965)
B1A77_RS09125	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B1A77_RS09130	COG1388	LysM domain
B1A77_RS09130	COG0791	NLP P60 protein
B1A77_RS09135	COG0463	Glycosyl transferase, family 2
B1A77_RS09145	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
B1A77_RS09165	COG3118	belongs to the thioredoxin family
B1A77_RS09175	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
B1A77_RS09190	COG0302	gtp cyclohydrolase
B1A77_RS09195	COG0602	queuosine metabolic process
B1A77_RS09205	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B1A77_RS09210	COG0358	DNA primase activity
B1A77_RS09215	COG1418	mRNA catabolic process
B1A77_RS09220	COG2137	regulation of response to DNA damage stimulus
B1A77_RS09225	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
B1A77_RS09230	COG1058	Belongs to the CinA family
B1A77_RS09230	COG1546	Belongs to the CinA family
B1A77_RS09250	COG1426	Protein conserved in bacteria
B1A77_RS09270	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
B1A77_RS09275	COG0124	histidyl-tRNA synthetase
B1A77_RS09280	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B1A77_RS09285	COG0735	belongs to the Fur family
B1A77_RS09290	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B1A77_RS09295	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B1A77_RS09300	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
B1A77_RS09300	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
B1A77_RS09305	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
B1A77_RS09310	COG0211	Belongs to the bacterial ribosomal protein bL27 family
B1A77_RS09320	COG0261	This protein binds to 23S rRNA in the presence of protein L20
B1A77_RS09325	COG1971	Probably functions as a manganese efflux pump
B1A77_RS09330	COG1530	ribonuclease E activity
B1A77_RS09345	COG0772	Belongs to the SEDS family
B1A77_RS09350	COG2894	cell division
B1A77_RS09355	COG0768	penicillin binding
B1A77_RS09370	COG1077	Cell shape determining protein MreB Mrl
B1A77_RS09375	COG2003	Belongs to the UPF0758 family
B1A77_RS09385	COG0424	maF-like protein
B1A77_RS09405	COG1323	Belongs to the UPF0348 family
B1A77_RS09410	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
B1A77_RS09415	COG0564	pseudouridine synthase activity
B1A77_RS09420	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
B1A77_RS09435	COG0471	metal ion transport
B1A77_RS09435	COG0490	domain, Protein
B1A77_RS09445	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
B1A77_RS09450	COG4770	biotin carboxylase activity
B1A77_RS09460	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B1A77_RS09465	COG0346	lactoylglutathione lyase activity
B1A77_RS09475	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B1A77_RS09475	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B1A77_RS09480	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B1A77_RS09480	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B1A77_RS09485	COG0427	acetyl-CoA hydrolase
B1A77_RS09495	COG0285	dihydrofolate synthase activity
B1A77_RS09500	COG0525	valine-tRNA ligase activity
B1A77_RS09505	COG0805	protein transport
B1A77_RS09510	COG0142	geranyltranstransferase activity
B1A77_RS09515	COG0218	Necessary for normal cell division and for the maintenance of normal septation
B1A77_RS09520	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B1A77_RS09525	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
B1A77_RS09530	COG0740	serine-type endopeptidase activity
B1A77_RS09535	COG0544	peptidyl-prolyl cis-trans isomerase activity
B1A77_RS09540	COG0516	GMP reductase activity
B1A77_RS09540	COG0517	IMP dehydrogenase activity
B1A77_RS09545	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
B1A77_RS09550	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
B1A77_RS09555	COG1850	ribulose-bisphosphate carboxylase activity
B1A77_RS09560	COG2233	PERMEase
B1A77_RS09575	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
B1A77_RS09575	COG0493	'glutamate synthase
B1A77_RS09580	COG0402	S-adenosylhomocysteine deaminase activity
B1A77_RS09585	COG0549	Belongs to the carbamate kinase family
B1A77_RS09590	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B1A77_RS09630	COG1970	mechanosensitive ion channel activity
B1A77_RS09635	COG3593	DNA synthesis involved in DNA repair
B1A77_RS09650	COG2837	iron assimilation
B1A77_RS09665	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B1A77_RS09675	COG2233	PERMEase
B1A77_RS09690	COG3273	potassium ion transport
B1A77_RS09690	COG0471	metal ion transport
B1A77_RS09695	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
B1A77_RS09700	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
B1A77_RS09705	COG2207	Transcriptional regulator
B1A77_RS09735	COG2223	nitrite transmembrane transporter activity
B1A77_RS09745	COG3069	C4-dicarboxylate transmembrane transporter activity
B1A77_RS09760	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B1A77_RS09765	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B1A77_RS09770	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
B1A77_RS09780	COG1473	amidohydrolase
B1A77_RS09795	COG0288	reversible hydration of carbon dioxide
B1A77_RS09800	COG0440	acetolactate synthase activity
B1A77_RS09805	COG0028	Belongs to the TPP enzyme family
B1A77_RS09815	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
B1A77_RS09835	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B1A77_RS09850	COG1217	gtp-binding protein TYPA
B1A77_RS09865	COG3679	Belongs to the UPF0342 family
B1A77_RS09870	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
B1A77_RS09875	COG0315	cyclic pyranopterin monophosphate synthase activity
B1A77_RS09880	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
B1A77_RS09910	COG0569	domain protein
B1A77_RS09915	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B1A77_RS09920	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B1A77_RS09940	COG0848	biopolymer transport protein
B1A77_RS09945	COG0811	peptide transport
B1A77_RS09950	COG4771	TonB-dependent receptor
B1A77_RS09955	COG4771	TonB-dependent receptor
B1A77_RS09955	COG4771	TonB-dependent receptor
B1A77_RS09960	COG2207	Transcriptional regulator
B1A77_RS09960	COG0662	Cupin 2, conserved barrel domain protein
B1A77_RS09990	COG1120	ATPase activity
B1A77_RS10000	COG0306	phosphate transporter
B1A77_RS10015	COG0488	(ABC) transporter
B1A77_RS10025	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B1A77_RS10030	COG0776	regulation of translation
B1A77_RS10035	COG3956	TIGRFAM MazG family protein
B1A77_RS10040	COG2244	polysaccharide biosynthetic process
B1A77_RS10045	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
B1A77_RS10055	COG0842	Transport permease protein
B1A77_RS10060	COG0842	Transport permease protein
B1A77_RS10065	COG1131	(ABC) transporter