locus-tag	class	description
OKW85_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
OKW85_RS00030	COG0187	DNA topoisomerase II activity
OKW85_RS00035	COG0833	amino acid
OKW85_RS00050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OKW85_RS00055	COG1253	flavin adenine dinucleotide binding
OKW85_RS00080	COG1216	Glycosyl transferase, family 2
OKW85_RS00095	COG0463	Glycosyl transferase, family 2
OKW85_RS00120	COG0562	UDP-galactopyranose mutase
OKW85_RS00140	COG0438	transferase activity, transferring glycosyl groups
OKW85_RS00145	COG0726	polysaccharide deacetylase
OKW85_RS00150	COG3475	LICD family
OKW85_RS00155	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
OKW85_RS00165	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
OKW85_RS00170	COG1086	Polysaccharide biosynthesis protein
OKW85_RS00245	COG4797	methyltransferase
OKW85_RS00245	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
OKW85_RS00305	COG0501	Belongs to the peptidase M48B family
OKW85_RS00320	COG0436	Aminotransferase
OKW85_RS00335	COG0640	Transcriptional regulator
OKW85_RS00345	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
OKW85_RS00360	COG4221	oxidoreductase activity
OKW85_RS00380	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
OKW85_RS00385	COG0747	negative chemotaxis
OKW85_RS00390	COG0444	Belongs to the ABC transporter superfamily
OKW85_RS00400	COG0210	DNA helicase
OKW85_RS00415	COG2801	Transposase and inactivated derivatives
OKW85_RS00430	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
OKW85_RS00455	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
OKW85_RS00460	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
OKW85_RS00465	COG0066	3-isopropylmalate dehydratase activity
OKW85_RS00470	COG0473	3-isopropylmalate dehydrogenase activity
OKW85_RS00490	COG1196	nuclear chromosome segregation
OKW85_RS00515	COG5295	Hep Hag repeat protein
OKW85_RS00520	COG0435	Glutathione S-transferase
OKW85_RS00525	COG2079	MmgE PrpD family protein
OKW85_RS00530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OKW85_RS00535	COG0765	amino acid transport
OKW85_RS00540	COG0765	amino acid transport
OKW85_RS00545	COG1126	abc transporter atp-binding protein
OKW85_RS00580	COG1879	ABC-type sugar transport system periplasmic component
OKW85_RS00585	COG1172	Belongs to the binding-protein-dependent transport system permease family
OKW85_RS00590	COG1129	ABC transporter
OKW85_RS00595	COG1869	D-ribose catabolic process
OKW85_RS00600	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
OKW85_RS00630	COG1122	ATPase activity
OKW85_RS00635	COG1122	ATPase activity
OKW85_RS00650	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
OKW85_RS00665	COG3210	domain, Protein
OKW85_RS00705	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
OKW85_RS00710	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
OKW85_RS00715	COG0131	Imidazoleglycerol-phosphate dehydratase
OKW85_RS00720	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
OKW85_RS00725	COG0107	imidazoleglycerol-phosphate synthase activity
OKW85_RS00730	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
OKW85_RS00740	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
OKW85_RS00745	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
OKW85_RS00750	COG0107	imidazoleglycerol-phosphate synthase activity
OKW85_RS00755	COG1966	Carbon starvation protein
OKW85_RS00780	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
OKW85_RS00790	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
OKW85_RS00795	COG1045	serine acetyltransferase
OKW85_RS00820	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
OKW85_RS00825	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
OKW85_RS00830	COG2731	YhcH YjgK YiaL family protein
OKW85_RS00835	COG0697	spore germination
OKW85_RS00860	COG3069	C4-dicarboxylate transmembrane transporter activity
OKW85_RS00865	COG0583	DNA-binding transcription factor activity
OKW85_RS00870	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
OKW85_RS00880	COG0471	metal ion transport
OKW85_RS00900	COG0512	Glutamine amidotransferase of anthranilate synthase
OKW85_RS00900	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
OKW85_RS00905	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
OKW85_RS00910	COG0134	indole-3-glycerol-phosphate synthase activity
OKW85_RS00915	COG0133	tryptophan synthase activity
OKW85_RS00920	COG0159	tryptophan synthase activity
OKW85_RS00950	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
OKW85_RS00965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OKW85_RS00980	COG0561	phosphatase activity
OKW85_RS00990	COG0518	GMP synthase (glutamine-hydrolyzing) activity
OKW85_RS00990	COG0519	Catalyzes the synthesis of GMP from XMP
OKW85_RS01000	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
OKW85_RS01010	COG4974	Belongs to the 'phage' integrase family
OKW85_RS01025	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
OKW85_RS01065	COG0456	acetyltransferase
OKW85_RS01070	COG1108	ABC-type Mn2 Zn2 transport systems permease components
OKW85_RS01075	COG1108	ABC-type Mn2 Zn2 transport systems permease components
OKW85_RS01080	COG1121	(ABC) transporter
OKW85_RS01085	COG0803	Belongs to the bacterial solute-binding protein 9 family
OKW85_RS01120	COG1151	hydroxylamine reductase activity
OKW85_RS01130	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
OKW85_RS01145	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
OKW85_RS01150	COG0420	3'-5' exonuclease activity
OKW85_RS01155	COG4717	serine-type aminopeptidase activity
OKW85_RS01160	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
OKW85_RS01165	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
OKW85_RS01170	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
OKW85_RS01175	COG3253	May function as heme-dependent peroxidase
OKW85_RS01185	COG2223	nitrite transmembrane transporter activity
OKW85_RS01190	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
OKW85_RS01195	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
OKW85_RS01200	COG1140	nitrate reductase beta subunit
OKW85_RS01205	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
OKW85_RS01210	COG2181	nitrate reductase activity
OKW85_RS01225	COG0497	DNA recombination
OKW85_RS01235	COG2814	Major facilitator Superfamily
OKW85_RS01240	COG0583	DNA-binding transcription factor activity
OKW85_RS01245	COG1279	arginine transmembrane transporter activity
OKW85_RS01250	COG2855	membrane
OKW85_RS01255	COG0288	reversible hydration of carbon dioxide
OKW85_RS01265	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
OKW85_RS01270	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
OKW85_RS01280	COG1108	ABC-type Mn2 Zn2 transport systems permease components
OKW85_RS01285	COG1121	(ABC) transporter
OKW85_RS01290	COG0803	Belongs to the bacterial solute-binding protein 9 family
OKW85_RS01345	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
OKW85_RS01350	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
OKW85_RS01355	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
OKW85_RS01360	COG1882	Formate acetyltransferase
OKW85_RS01380	COG2011	ABC-type metal ion transport system permease component
OKW85_RS01395	COG1132	(ABC) transporter
OKW85_RS01405	COG0471	metal ion transport
OKW85_RS01420	COG0626	cystathionine gamma-synthase activity
OKW85_RS01425	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
OKW85_RS01430	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
OKW85_RS01435	COG2873	o-acetylhomoserine
OKW85_RS01455	COG0701	Predicted permease
OKW85_RS01460	COG0523	cobalamin synthesis protein
OKW85_RS01465	COG2195	Cleaves the N-terminal amino acid of tripeptides
OKW85_RS01470	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
OKW85_RS01490	COG0668	transmembrane transport
OKW85_RS01495	COG1686	Belongs to the peptidase S11 family
OKW85_RS01505	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
OKW85_RS01515	COG2080	2 iron, 2 sulfur cluster binding
OKW85_RS01520	COG2080	2 iron, 2 sulfur cluster binding
OKW85_RS01520	COG1529	Aldehyde oxidase and xanthine dehydrogenase
OKW85_RS01540	COG3608	succinylglutamate desuccinylase aspartoacylase
OKW85_RS01540	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
OKW85_RS01550	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
OKW85_RS01555	COG4856	YbbR-like protein
OKW85_RS01560	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
OKW85_RS01565	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
OKW85_RS01570	COG1794	racemase activity, acting on amino acids and derivatives
OKW85_RS01585	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
OKW85_RS01590	COG0180	Tryptophanyl-tRNA synthetase
OKW85_RS01605	COG0765	amino acid transport
OKW85_RS01610	COG1126	abc transporter atp-binding protein
OKW85_RS01620	COG0589	response to stress
OKW85_RS01625	COG0640	Transcriptional regulator
OKW85_RS01640	COG0725	ABC transporter, periplasmic molybdate-binding protein
OKW85_RS01645	COG4149	molybdate abc transporter
OKW85_RS01650	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
OKW85_RS01680	COG1592	Rubrerythrin
OKW85_RS01690	COG0709	Synthesizes selenophosphate from selenide and ATP
OKW85_RS01710	COG0778	Nitroreductase
OKW85_RS01715	COG2261	transglycosylase associated protein
OKW85_RS01725	COG0012	GTP binding
OKW85_RS01735	COG0436	Aminotransferase
OKW85_RS01740	COG2814	Major facilitator Superfamily
OKW85_RS01745	COG0360	Binds together with S18 to 16S ribosomal RNA
OKW85_RS01750	COG0629	single-stranded DNA binding
OKW85_RS01755	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
OKW85_RS01770	COG0535	radical SAM domain protein
OKW85_RS01770	COG1433	Dinitrogenase iron-molybdenum cofactor
OKW85_RS01775	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
OKW85_RS01795	COG0220	tRNA (guanine-N7-)-methyltransferase activity
OKW85_RS01800	COG0772	Belongs to the SEDS family
OKW85_RS01845	COG2195	Cleaves the N-terminal amino acid of tripeptides
OKW85_RS01860	COG2040	homocysteine
OKW85_RS01875	COG0426	domain, Protein
OKW85_RS01885	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
OKW85_RS01890	COG0583	DNA-binding transcription factor activity
OKW85_RS01895	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
OKW85_RS01910	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
OKW85_RS01915	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
OKW85_RS01920	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
OKW85_RS01925	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
OKW85_RS01930	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
OKW85_RS01940	COG0151	Belongs to the GarS family
OKW85_RS01945	COG1169	isochorismate synthase
OKW85_RS01950	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
OKW85_RS01955	COG0596	Alpha beta hydrolase
OKW85_RS01960	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
OKW85_RS01965	COG0318	PFAM AMP-dependent synthetase and ligase
OKW85_RS01970	COG4948	Mandelate Racemase Muconate Lactonizing
OKW85_RS02015	COG0573	inorganic phosphate transmembrane transporter activity
OKW85_RS02025	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
OKW85_RS02050	COG1649	PFAM Uncharacterised BCR, COG1649
OKW85_RS02050	COG0726	polysaccharide deacetylase
OKW85_RS02055	COG5434	Belongs to the glycosyl hydrolase 28 family
OKW85_RS02055	COG4632	Exopolysaccharide biosynthesis protein
OKW85_RS02065	COG0859	PFAM glycosyl transferase family 9
OKW85_RS02090	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
OKW85_RS02125	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
OKW85_RS02130	COG0284	orotidine-5'-phosphate decarboxylase activity
OKW85_RS02155	COG1464	Belongs to the NlpA lipoprotein family
OKW85_RS02160	COG1575	Belongs to the MenA family. Type 1 subfamily
OKW85_RS02175	COG0251	oxidation-reduction process
OKW85_RS02180	COG3681	Belongs to the UPF0597 family
OKW85_RS02185	COG2223	nitrite transmembrane transporter activity
OKW85_RS02195	COG0590	tRNA wobble adenosine to inosine editing
OKW85_RS02225	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
OKW85_RS02230	COG2011	ABC-type metal ion transport system permease component
OKW85_RS02235	COG4496	protein, YerC YecD
OKW85_RS02240	COG0730	response to heat
OKW85_RS02245	COG1028	Short-chain dehydrogenase reductase Sdr
OKW85_RS02255	COG3339	Conserved Protein
OKW85_RS02260	COG0824	Thioesterase
OKW85_RS02265	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
OKW85_RS02290	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
OKW85_RS02305	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
OKW85_RS02310	COG0281	malic enzyme
OKW85_RS02340	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
OKW85_RS02345	COG1914	H( )-stimulated, divalent metal cation uptake system
OKW85_RS02350	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
OKW85_RS02355	COG1984	allophanate hydrolase subunit 2
OKW85_RS02370	COG0534	Mate efflux family protein
OKW85_RS02375	COG2885	chlorophyll binding
OKW85_RS02380	COG0628	permease
OKW85_RS02390	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
OKW85_RS02395	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
OKW85_RS02400	COG2226	methyltransferase
OKW85_RS02470	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
OKW85_RS02475	COG2244	polysaccharide biosynthetic process
OKW85_RS02480	COG3956	TIGRFAM MazG family protein
OKW85_RS02485	COG0776	regulation of translation
OKW85_RS02490	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
OKW85_RS02500	COG0488	(ABC) transporter
OKW85_RS02515	COG0306	phosphate transporter
OKW85_RS02535	COG1120	ATPase activity
OKW85_RS02560	COG2832	Protein of unknown function (DUF454)
OKW85_RS02565	COG2207	Transcriptional regulator
OKW85_RS02565	COG0662	Cupin 2, conserved barrel domain protein
OKW85_RS02570	COG4771	TonB-dependent receptor
OKW85_RS02575	COG0811	peptide transport
OKW85_RS02580	COG0848	biopolymer transport protein
OKW85_RS02600	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
OKW85_RS02605	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
OKW85_RS02610	COG0569	domain protein
OKW85_RS02630	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
OKW85_RS02635	COG0315	cyclic pyranopterin monophosphate synthase activity
OKW85_RS02640	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
OKW85_RS02645	COG3679	Belongs to the UPF0342 family
OKW85_RS02655	COG1217	gtp-binding protein TYPA
OKW85_RS02700	COG1704	LemA family
OKW85_RS02720	COG0028	Belongs to the TPP enzyme family
OKW85_RS02725	COG0440	acetolactate synthase activity
OKW85_RS02730	COG0288	reversible hydration of carbon dioxide
OKW85_RS02745	COG1473	amidohydrolase
OKW85_RS02755	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
OKW85_RS02760	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
OKW85_RS02765	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
OKW85_RS02780	COG3069	C4-dicarboxylate transmembrane transporter activity
OKW85_RS02785	COG2223	nitrite transmembrane transporter activity
OKW85_RS02795	COG3859	Proton-coupled thiamine transporter YuaJ
OKW85_RS02805	COG0303	'Molybdopterin
OKW85_RS02820	COG0542	response to heat
OKW85_RS02840	COG2207	Transcriptional regulator
OKW85_RS02845	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
OKW85_RS02850	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
OKW85_RS02855	COG0471	metal ion transport
OKW85_RS02875	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
OKW85_RS02895	COG2837	iron assimilation
OKW85_RS02900	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
OKW85_RS02910	COG3593	DNA synthesis involved in DNA repair
OKW85_RS02915	COG1970	mechanosensitive ion channel activity
OKW85_RS02925	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
OKW85_RS02955	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
OKW85_RS02960	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
OKW85_RS02965	COG0549	Belongs to the carbamate kinase family
OKW85_RS02970	COG0402	S-adenosylhomocysteine deaminase activity
OKW85_RS02975	COG0493	'glutamate synthase
OKW85_RS02975	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
OKW85_RS02990	COG2233	PERMEase
OKW85_RS02995	COG1850	ribulose-bisphosphate carboxylase activity
OKW85_RS03000	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
OKW85_RS03005	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
OKW85_RS03010	COG0516	GMP reductase activity
OKW85_RS03010	COG0517	IMP dehydrogenase activity
OKW85_RS03015	COG0544	peptidyl-prolyl cis-trans isomerase activity
OKW85_RS03020	COG0740	serine-type endopeptidase activity
OKW85_RS03025	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
OKW85_RS03030	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
OKW85_RS03035	COG0218	Necessary for normal cell division and for the maintenance of normal septation
OKW85_RS03040	COG0142	geranyltranstransferase activity
OKW85_RS03045	COG0805	protein transport
OKW85_RS03050	COG0525	valine-tRNA ligase activity
OKW85_RS03055	COG0285	dihydrofolate synthase activity
OKW85_RS03065	COG0427	acetyl-CoA hydrolase
OKW85_RS03070	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
OKW85_RS03070	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
OKW85_RS03075	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
OKW85_RS03075	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
OKW85_RS03085	COG0346	lactoylglutathione lyase activity
OKW85_RS03090	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
OKW85_RS03105	COG4770	biotin carboxylase activity
OKW85_RS03110	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
OKW85_RS03120	COG0471	metal ion transport
OKW85_RS03120	COG0490	domain, Protein
OKW85_RS03125	COG0490	domain, Protein
OKW85_RS03125	COG0471	metal ion transport
OKW85_RS03140	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
OKW85_RS03145	COG0564	pseudouridine synthase activity
OKW85_RS03150	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
OKW85_RS03155	COG1323	Belongs to the UPF0348 family
OKW85_RS03180	COG0424	maF-like protein
OKW85_RS03185	COG2003	Belongs to the UPF0758 family
OKW85_RS03190	COG1077	Cell shape determining protein MreB Mrl
OKW85_RS03205	COG0768	penicillin binding
OKW85_RS03210	COG2894	cell division
OKW85_RS03215	COG0772	Belongs to the SEDS family
OKW85_RS03230	COG1530	ribonuclease E activity
OKW85_RS03235	COG1971	Probably functions as a manganese efflux pump
OKW85_RS03240	COG0261	This protein binds to 23S rRNA in the presence of protein L20
OKW85_RS03250	COG0211	Belongs to the bacterial ribosomal protein bL27 family
OKW85_RS03255	COG4619	ABC transporter
OKW85_RS03260	COG0390	transport system, permease component
OKW85_RS03265	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
OKW85_RS03270	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
OKW85_RS03270	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
OKW85_RS03275	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
OKW85_RS03280	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OKW85_RS03285	COG0735	belongs to the Fur family
OKW85_RS03290	COG0635	Involved in the biosynthesis of porphyrin-containing compound
OKW85_RS03300	COG0635	Involved in the biosynthesis of porphyrin-containing compound
OKW85_RS03305	COG0124	histidyl-tRNA synthetase
OKW85_RS03310	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
OKW85_RS03330	COG1426	Protein conserved in bacteria
OKW85_RS03345	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
OKW85_RS03350	COG1546	Belongs to the CinA family
OKW85_RS03350	COG1058	Belongs to the CinA family
OKW85_RS03355	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
OKW85_RS03360	COG2137	regulation of response to DNA damage stimulus
OKW85_RS03365	COG1418	mRNA catabolic process
OKW85_RS03370	COG0358	DNA primase activity
OKW85_RS03375	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
OKW85_RS03390	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
OKW85_RS03400	COG3118	belongs to the thioredoxin family
OKW85_RS03420	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
OKW85_RS03430	COG0463	Glycosyl transferase, family 2
OKW85_RS03435	COG0791	NLP P60 protein
OKW85_RS03435	COG1388	LysM domain
OKW85_RS03440	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
OKW85_RS03445	COG4472	Bacterial protein of unknown function (DUF965)
OKW85_RS03450	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
OKW85_RS03465	COG4122	O-methyltransferase activity
OKW85_RS03470	COG0826	peptidase U32
OKW85_RS03485	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
OKW85_RS03490	COG2814	Major facilitator Superfamily
OKW85_RS03495	COG0471	metal ion transport
OKW85_RS03500	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
OKW85_RS03505	COG0291	Belongs to the bacterial ribosomal protein bL35 family
OKW85_RS03510	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
OKW85_RS03530	COG2315	Protein conserved in bacteria
OKW85_RS03650	COG0546	phosphoglycolate phosphatase activity
OKW85_RS03665	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
OKW85_RS03675	COG2244	polysaccharide biosynthetic process
OKW85_RS03680	COG0191	fructose-bisphosphate aldolase activity
OKW85_RS03685	COG0564	pseudouridine synthase activity
OKW85_RS03695	COG1666	GTP binding
OKW85_RS03700	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
OKW85_RS03740	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
OKW85_RS03745	COG1120	ATPase activity
OKW85_RS03785	COG4822	anaerobic cobalamin biosynthetic process
OKW85_RS03805	COG2033	superoxide reductase activity
OKW85_RS03825	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
OKW85_RS03835	COG3118	belongs to the thioredoxin family
OKW85_RS03850	COG2001	Belongs to the MraZ family
OKW85_RS03855	COG0275	rRNA processing
OKW85_RS03860	COG3116	cell division
OKW85_RS03865	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
OKW85_RS03870	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
OKW85_RS03875	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
OKW85_RS03880	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
OKW85_RS03890	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
OKW85_RS03915	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
OKW85_RS03930	COG4224	UPF0291 protein
OKW85_RS03935	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
OKW85_RS03950	COG0254	rRNA binding
OKW85_RS03955	COG3872	metal-dependent enzyme
OKW85_RS03960	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
OKW85_RS03965	COG2890	protein-(glutamine-N5) methyltransferase activity
OKW85_RS03970	COG0009	L-threonylcarbamoyladenylate synthase
OKW85_RS03975	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
OKW85_RS03980	COG0698	ribose 5-phosphate isomerase
OKW85_RS03985	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
OKW85_RS04005	COG0126	phosphoglycerate kinase activity
OKW85_RS04010	COG0149	triose-phosphate isomerase activity
OKW85_RS04025	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
OKW85_RS04035	COG1459	type II secretion system
OKW85_RS04040	COG4968	Prepilin-type N-terminal cleavage methylation domain
OKW85_RS04085	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
OKW85_RS04090	COG0205	6-phosphofructokinase activity
OKW85_RS04095	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
OKW85_RS04100	COG1136	(ABC) transporter
OKW85_RS04105	COG0577	efflux transmembrane transporter activity
OKW85_RS04105	COG1136	(ABC) transporter
OKW85_RS04115	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
OKW85_RS04120	COG0072	phenylalanine-tRNA ligase activity
OKW85_RS04120	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
OKW85_RS04125	COG0826	peptidase U32
OKW85_RS04130	COG1193	negative regulation of DNA recombination
OKW85_RS04135	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
OKW85_RS04140	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
OKW85_RS04155	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
OKW85_RS04155	COG0574	Belongs to the PEP-utilizing enzyme family
OKW85_RS04160	COG0517	IMP dehydrogenase activity
OKW85_RS04165	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
OKW85_RS04170	COG0232	Belongs to the dGTPase family. Type 2 subfamily
OKW85_RS04175	COG0227	Belongs to the bacterial ribosomal protein bL28 family
OKW85_RS04180	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
OKW85_RS04185	COG1942	4-Oxalocrotonate Tautomerase
OKW85_RS04190	COG0517	IMP dehydrogenase activity
OKW85_RS04190	COG0516	GMP reductase activity
OKW85_RS04195	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
OKW85_RS04200	COG0688	phosphatidylethanolamine metabolic process
OKW85_RS04215	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
OKW85_RS04230	COG0736	holo-[acyl-carrier-protein] synthase activity
OKW85_RS04235	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
OKW85_RS04235	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
OKW85_RS04240	COG2333	competence protein COMEC
OKW85_RS04240	COG0658	competence protein
OKW85_RS04255	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
OKW85_RS04260	COG0802	atpase or kinase
OKW85_RS04265	COG1214	PFAM Peptidase M22, glycoprotease
OKW85_RS04270	COG0456	acetyltransferase
OKW85_RS04290	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
OKW85_RS04295	COG0459	protein refolding
OKW85_RS04305	COG0396	ATPase activity
OKW85_RS04320	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
OKW85_RS04325	COG0822	iron-sulfur transferase activity
OKW85_RS04340	COG4463	regulation of RNA biosynthetic process
OKW85_RS04345	COG3880	PFAM UvrB UvrC protein
OKW85_RS04350	COG3869	Catalyzes the specific phosphorylation of arginine residues in
OKW85_RS04355	COG0542	response to heat
OKW85_RS04360	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
OKW85_RS04365	COG4956	integral membrane protein (PIN domain superfamily)
OKW85_RS04370	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
OKW85_RS04370	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
OKW85_RS04375	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
OKW85_RS04380	COG0385	Bile acid
OKW85_RS04385	COG0215	cysteine-tRNA ligase activity
OKW85_RS04390	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
OKW85_RS04395	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
OKW85_RS04415	COG0557	exoribonuclease II activity
OKW85_RS04420	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
OKW85_RS04430	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
OKW85_RS04455	COG1227	inorganic diphosphatase activity
OKW85_RS04460	COG0210	DNA helicase
OKW85_RS04465	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
OKW85_RS04475	COG0154	amidase activity
OKW85_RS04480	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
OKW85_RS04495	COG1242	4 iron, 4 sulfur cluster binding
OKW85_RS04500	COG1702	phosphate starvation-inducible protein PhoH
OKW85_RS04510	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
OKW85_RS04515	COG1253	flavin adenine dinucleotide binding
OKW85_RS04565	COG0752	glycyl-tRNA synthetase alpha subunit
OKW85_RS04570	COG0751	glycine-tRNA ligase activity
OKW85_RS04595	COG0792	nuclease activity
OKW85_RS04605	COG0758	DNA mediated transformation
OKW85_RS04610	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
OKW85_RS04615	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
OKW85_RS04620	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
OKW85_RS04625	COG3858	chitin binding
OKW85_RS04625	COG1388	LysM domain
OKW85_RS04630	COG0495	leucyl-tRNA aminoacylation
OKW85_RS04645	COG1555	photosystem II stabilization
OKW85_RS04685	COG0028	Belongs to the TPP enzyme family
OKW85_RS04695	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
OKW85_RS04695	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
OKW85_RS04705	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
OKW85_RS04705	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
OKW85_RS04715	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
OKW85_RS04720	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
OKW85_RS04725	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
OKW85_RS04730	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
OKW85_RS04735	COG0402	S-adenosylhomocysteine deaminase activity
OKW85_RS04740	COG2226	methyltransferase
OKW85_RS04770	COG0671	phosphoesterase, PA-phosphatase related
OKW85_RS04775	COG2720	vancomycin resistance protein
OKW85_RS04795	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
OKW85_RS04800	COG0385	Bile acid
OKW85_RS04810	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
OKW85_RS04815	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
OKW85_RS04820	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
OKW85_RS04825	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
OKW85_RS04830	COG0497	DNA recombination
OKW85_RS04835	COG1438	arginine binding
OKW85_RS04845	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
OKW85_RS04850	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
OKW85_RS04865	COG1722	exodeoxyribonuclease VII activity
OKW85_RS04875	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
OKW85_RS04880	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
OKW85_RS04895	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
OKW85_RS04900	COG0006	proline dipeptidase activity
OKW85_RS04905	COG1187	pseudouridine synthase activity
OKW85_RS04910	COG0406	alpha-ribazole phosphatase activity
OKW85_RS04925	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
OKW85_RS04935	COG1492	cobalamin metabolic process
OKW85_RS04940	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
OKW85_RS04955	COG0105	UTP biosynthetic process
OKW85_RS04965	COG0083	homoserine kinase activity
OKW85_RS04970	COG0460	homoserine dehydrogenase
OKW85_RS04975	COG4492	Belongs to the UPF0735 family
OKW85_RS04985	COG3394	polysaccharide catabolic process
OKW85_RS04990	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
OKW85_RS04995	COG1132	(ABC) transporter
OKW85_RS05000	COG1132	(ABC) transporter
OKW85_RS05005	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
OKW85_RS05015	COG0174	glutamine synthetase
OKW85_RS05020	COG1610	YqeY-like protein
OKW85_RS05025	COG0828	Belongs to the bacterial ribosomal protein bS21 family
OKW85_RS05030	COG0537	adenosine 5'-monophosphoramidase activity
OKW85_RS05035	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
OKW85_RS05040	COG1385	rRNA (uridine-N3-)-methyltransferase activity
OKW85_RS05050	COG0484	heat shock protein binding
OKW85_RS05055	COG0443	Heat shock 70 kDa protein
OKW85_RS05060	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
OKW85_RS05075	COG0635	Involved in the biosynthesis of porphyrin-containing compound
OKW85_RS05080	COG0481	GTPase activity
OKW85_RS05085	COG0482	sulfurtransferase activity
OKW85_RS05090	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
OKW85_RS05100	COG2136	Putative SAM-dependent methyltransferase
OKW85_RS05100	COG2521	methyltransferase
OKW85_RS05105	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
OKW85_RS05110	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
OKW85_RS05115	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
OKW85_RS05125	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
OKW85_RS05125	COG1796	DNA polymerase
OKW85_RS05130	COG0442	prolyl-tRNA aminoacylation
OKW85_RS05135	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
OKW85_RS05140	COG0750	zinc metalloprotease
OKW85_RS05145	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
OKW85_RS05150	COG4589	Belongs to the CDS family
OKW85_RS05165	COG0233	cytoplasmic translational termination
OKW85_RS05170	COG0528	UMP kinase activity
OKW85_RS05175	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
OKW85_RS05180	COG0052	Belongs to the universal ribosomal protein uS2 family
OKW85_RS05185	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
OKW85_RS05190	COG1162	GTPase activity
OKW85_RS05195	COG2815	serine threonine protein kinase
OKW85_RS05195	COG0515	serine threonine protein kinase
OKW85_RS05200	COG0631	protein serine/threonine phosphatase activity
OKW85_RS05205	COG0820	rRNA (adenine-C2-)-methyltransferase activity
OKW85_RS05210	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
OKW85_RS05210	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
OKW85_RS05220	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
OKW85_RS05225	COG0242	peptide deformylase activity
OKW85_RS05230	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
OKW85_RS05235	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
OKW85_RS05240	COG0659	secondary active sulfate transmembrane transporter activity
OKW85_RS05245	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
OKW85_RS05250	COG1758	RNA polymerase activity
OKW85_RS05255	COG0194	GDP metabolic process
OKW85_RS05265	COG1561	YicC-like family, N-terminal region
OKW85_RS05280	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
OKW85_RS05285	COG0742	ribosomal rna small subunit methyltransferase
OKW85_RS05290	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
OKW85_RS05295	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
OKW85_RS05300	COG1160	GTP binding
OKW85_RS05305	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
OKW85_RS05305	COG0539	negative regulation of cytoplasmic translation
OKW85_RS05320	COG2081	HI0933 family
OKW85_RS05325	COG1187	pseudouridine synthase activity
OKW85_RS05330	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
OKW85_RS05335	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
OKW85_RS05350	COG1683	Conserved Protein
OKW85_RS05380	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
OKW85_RS05385	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
OKW85_RS05390	COG0569	domain protein
OKW85_RS05395	COG2996	Protein conserved in bacteria
OKW85_RS05400	COG0799	negative regulation of ribosome biogenesis
OKW85_RS05410	COG1713	HD superfamily hydrolase involved in NAD metabolism
OKW85_RS05415	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
OKW85_RS05420	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
OKW85_RS05425	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
OKW85_RS05435	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
OKW85_RS05440	COG0793	Belongs to the peptidase S41A family
OKW85_RS05440	COG3409	Peptidoglycan-binding domain 1 protein
OKW85_RS05445	COG0739	heme binding
OKW85_RS05450	COG2177	Part of the ABC transporter FtsEX involved in
OKW85_RS05455	COG2884	Cell division ATP-binding protein ftsE
OKW85_RS05460	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
OKW85_RS05465	COG3959	Transketolase, thiamine diphosphate binding domain
OKW85_RS05490	COG0653	protein targeting
OKW85_RS05500	COG1278	Cold shock
OKW85_RS05510	COG0765	amino acid transport
OKW85_RS05515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
OKW85_RS05525	COG1040	competence protein
OKW85_RS05530	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
OKW85_RS05540	COG0196	riboflavin kinase activity
OKW85_RS05550	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
OKW85_RS05555	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
OKW85_RS05560	COG3064	Membrane
OKW85_RS05560	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
OKW85_RS05560	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
OKW85_RS05560	COG3064	Membrane
OKW85_RS05565	COG1358	cellular component organization or biogenesis
OKW85_RS05575	COG0195	Participates in both transcription termination and antitermination
OKW85_RS05580	COG0779	Required for maturation of 30S ribosomal subunits
OKW85_RS05590	COG0741	lytic transglycosylase activity
OKW85_RS05595	COG0237	dephospho-CoA kinase activity
OKW85_RS05600	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
OKW85_RS05600	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
OKW85_RS05605	COG0268	Binds directly to 16S ribosomal RNA
OKW85_RS05615	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
OKW85_RS05620	COG2252	PERMEase
OKW85_RS05625	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
OKW85_RS05640	COG0756	dUTP diphosphatase activity
OKW85_RS05645	COG1185	polyribonucleotide nucleotidyltransferase activity
OKW85_RS05655	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
OKW85_RS05660	COG4120	Belongs to the binding-protein-dependent transport system permease family
OKW85_RS05680	COG1362	aminopeptidase activity
OKW85_RS05685	COG2176	DNA-directed DNA polymerase activity
OKW85_RS05695	COG0859	PFAM glycosyl transferase family 9
OKW85_RS05700	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
OKW85_RS05705	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
OKW85_RS05710	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
OKW85_RS05710	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
OKW85_RS05715	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
OKW85_RS05725	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
OKW85_RS05730	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
OKW85_RS05735	COG1362	aminopeptidase activity
OKW85_RS05750	COG0471	metal ion transport
OKW85_RS05760	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
OKW85_RS05780	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
OKW85_RS05790	COG0179	Fumarylacetoacetate (FAA) hydrolase
OKW85_RS05795	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
OKW85_RS05905	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
OKW85_RS05910	COG0861	Integral membrane protein TerC family
OKW85_RS05915	COG0861	Integral membrane protein TerC family
OKW85_RS05920	COG0534	Mate efflux family protein
OKW85_RS05925	COG0322	excinuclease ABC activity
OKW85_RS05930	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
OKW85_RS05935	COG0556	nucleotide-excision repair
OKW85_RS05945	COG0552	protein localization to endoplasmic reticulum
OKW85_RS05950	COG1196	nuclear chromosome segregation
OKW85_RS05955	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
OKW85_RS05960	COG0571	ribonuclease III activity
OKW85_RS05965	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
OKW85_RS05970	COG2070	2-Nitropropane dioxygenase
OKW85_RS05975	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
OKW85_RS05980	COG1028	Short-chain dehydrogenase reductase Sdr
OKW85_RS05985	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
OKW85_RS05995	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
OKW85_RS06000	COG0416	fatty acid biosynthetic process
OKW85_RS06010	COG0333	Belongs to the bacterial ribosomal protein bL32 family
OKW85_RS06020	COG1773	rubredoxin
OKW85_RS06040	COG0602	queuosine metabolic process
OKW85_RS06090	COG0438	transferase activity, transferring glycosyl groups
OKW85_RS06105	COG3475	LICD family
OKW85_RS06110	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
OKW85_RS06115	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
OKW85_RS06165	COG0488	(ABC) transporter
OKW85_RS06170	COG1450	Type ii and iii secretion system protein
OKW85_RS06180	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
OKW85_RS06185	COG0166	Belongs to the GPI family
OKW85_RS06195	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
OKW85_RS06205	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
OKW85_RS06215	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
OKW85_RS06225	COG1268	BioY protein
OKW85_RS06260	COG0409	Hydrogenase expression formation protein
OKW85_RS06265	COG0298	carbon dioxide binding
OKW85_RS06320	COG1918	ferrous iron import across plasma membrane
OKW85_RS06320	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
OKW85_RS06335	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
OKW85_RS06340	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
OKW85_RS06345	COG0786	glutamate:sodium symporter activity
OKW85_RS06350	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
OKW85_RS06355	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
OKW85_RS06360	COG0583	DNA-binding transcription factor activity
OKW85_RS06365	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
OKW85_RS06370	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
OKW85_RS06370	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
OKW85_RS06375	COG3584	3D domain protein
OKW85_RS06375	COG1388	LysM domain
OKW85_RS06380	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
OKW85_RS06395	COG0084	hydrolase, TatD family'
OKW85_RS06400	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
OKW85_RS06400	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
OKW85_RS06405	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
OKW85_RS06415	COG1774	PSP1 C-terminal conserved region
OKW85_RS06420	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
OKW85_RS06425	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
OKW85_RS06430	COG1982	Orn Lys Arg decarboxylase major
OKW85_RS06435	COG0193	aminoacyl-tRNA hydrolase activity
OKW85_RS06440	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
OKW85_RS06445	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
OKW85_RS06450	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
OKW85_RS06455	COG3583	domain protein
OKW85_RS06455	COG3584	3D domain protein
OKW85_RS06465	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
OKW85_RS06480	COG3585	molybdate ion transport
OKW85_RS06500	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
OKW85_RS06505	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
OKW85_RS06515	COG1862	Preprotein translocase
OKW85_RS06520	COG0343	queuine tRNA-ribosyltransferase activity
OKW85_RS06530	COG2385	sporulation resulting in formation of a cellular spore
OKW85_RS06535	COG2255	four-way junction helicase activity
OKW85_RS06540	COG0632	four-way junction helicase activity
OKW85_RS06545	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
OKW85_RS06550	COG0217	transcriptional regulatory protein
OKW85_RS06555	COG4752	Belongs to the RNA methyltransferase TrmD family
OKW85_RS06580	COG0702	epimerase
OKW85_RS06585	COG0336	Belongs to the RNA methyltransferase TrmD family
OKW85_RS06590	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
OKW85_RS06610	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
OKW85_RS06615	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
OKW85_RS06625	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
OKW85_RS06640	COG2217	Heavy metal translocating P-type atpase
OKW85_RS06645	COG1739	Uncharacterized protein family UPF0029
OKW85_RS06655	COG0583	DNA-binding transcription factor activity
OKW85_RS06660	COG0167	dihydroorotate dehydrogenase activity
OKW85_RS06665	COG0543	2 iron, 2 sulfur cluster binding
OKW85_RS06670	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
OKW85_RS06675	COG0540	Belongs to the ATCase OTCase family
OKW85_RS06685	COG1481	regulation of sporulation
OKW85_RS06690	COG0391	Required for morphogenesis under gluconeogenic growth conditions
OKW85_RS06695	COG1660	Displays ATPase and GTPase activities
OKW85_RS06710	COG0497	DNA recombination
OKW85_RS06715	COG0497	DNA recombination
OKW85_RS06725	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
OKW85_RS06735	COG4372	Transposase
OKW85_RS06745	COG1137	ATPase activity
OKW85_RS06750	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
OKW85_RS06765	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
OKW85_RS06775	COG2877	3-deoxy-8-phosphooctulonate synthase activity
OKW85_RS06780	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
OKW85_RS06785	COG1663	tetraacyldisaccharide 4'-kinase activity
OKW85_RS06790	COG1519	Transferase
OKW85_RS06795	COG1132	(ABC) transporter
OKW85_RS06800	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
OKW85_RS06810	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
OKW85_RS06815	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
OKW85_RS06820	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
OKW85_RS06825	COG1560	Kdo2-lipid A biosynthetic process
OKW85_RS06830	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
OKW85_RS06870	COG1127	ABC transporter
OKW85_RS06875	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
OKW85_RS06900	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
OKW85_RS06905	COG1494	fructose-1,6-bisphosphatase
OKW85_RS06910	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
OKW85_RS06925	COG0402	S-adenosylhomocysteine deaminase activity
OKW85_RS06930	COG2252	PERMEase
OKW85_RS06935	COG1982	Orn Lys Arg decarboxylase major
OKW85_RS06940	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
OKW85_RS06945	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
OKW85_RS06950	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
OKW85_RS06955	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
OKW85_RS06975	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
OKW85_RS06985	COG0037	tRNA processing
OKW85_RS06995	COG1098	S1 RNA binding domain
OKW85_RS07005	COG0039	L-malate dehydrogenase activity
OKW85_RS07015	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
OKW85_RS07015	COG0302	gtp cyclohydrolase
OKW85_RS07020	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
OKW85_RS07025	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
OKW85_RS07035	COG0488	(ABC) transporter
OKW85_RS07045	COG1619	proteins homologs of microcin C7 resistance protein MccF
OKW85_RS07050	COG4166	transmembrane transport
OKW85_RS07060	COG4608	Belongs to the ABC transporter superfamily
OKW85_RS07065	COG0444	Belongs to the ABC transporter superfamily
OKW85_RS07070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
OKW85_RS07075	COG0601	transmembrane transport
OKW85_RS07095	COG4988	ABC transporter
OKW85_RS07100	COG1294	oxidase, subunit
OKW85_RS07105	COG1271	oxidase subunit
OKW85_RS07110	COG1959	2 iron, 2 sulfur cluster binding
OKW85_RS07120	COG0521	Mo-molybdopterin cofactor biosynthetic process
OKW85_RS07125	COG0726	polysaccharide deacetylase
OKW85_RS07170	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
OKW85_RS07180	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
OKW85_RS07185	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
OKW85_RS07195	COG0419	ATPase involved in DNA repair
OKW85_RS07200	COG0420	3'-5' exonuclease activity
OKW85_RS07205	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
OKW85_RS07210	COG0735	belongs to the Fur family
OKW85_RS07215	COG0513	Belongs to the DEAD box helicase family
OKW85_RS07240	COG1012	belongs to the aldehyde dehydrogenase family
OKW85_RS07245	COG2183	response to ionizing radiation
OKW85_RS07250	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
OKW85_RS07255	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
OKW85_RS07260	COG0514	ATP-dependent DNA helicase (RecQ)
OKW85_RS07265	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
OKW85_RS07275	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
OKW85_RS07275	COG4797	methyltransferase
OKW85_RS07285	COG0583	DNA-binding transcription factor activity
OKW85_RS07325	COG2301	Belongs to the HpcH HpaI aldolase family
OKW85_RS07330	COG3052	prosthetic group binding
OKW85_RS07335	COG0471	metal ion transport
OKW85_RS07340	COG0583	DNA-binding transcription factor activity
OKW85_RS07345	COG0670	Belongs to the BI1 family
OKW85_RS07385	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
OKW85_RS07390	COG0113	porphobilinogen synthase activity
OKW85_RS07395	COG1587	Uroporphyrinogen-III synthase
OKW85_RS07395	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
OKW85_RS07405	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
OKW85_RS07410	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
OKW85_RS07410	COG1648	precorrin-2 dehydrogenase activity
OKW85_RS07420	COG2302	S4 RNA-binding domain
OKW85_RS07425	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
OKW85_RS07430	COG1799	cell septum assembly
OKW85_RS07460	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
OKW85_RS07465	COG1119	ATPase activity
OKW85_RS07470	COG0440	acetolactate synthase activity
OKW85_RS07475	COG0028	Belongs to the TPP enzyme family
OKW85_RS07480	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
OKW85_RS07485	COG0129	dihydroxy-acid dehydratase activity
OKW85_RS07490	COG0471	metal ion transport
OKW85_RS07495	COG0662	Cupin 2, conserved barrel domain protein
OKW85_RS07505	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
OKW85_RS07510	COG0363	glucosamine-6-phosphate deaminase activity
OKW85_RS07515	COG1024	Enoyl-CoA hydratase
OKW85_RS07520	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
OKW85_RS07525	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
OKW85_RS07530	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
OKW85_RS07535	COG0583	DNA-binding transcription factor activity
OKW85_RS07540	COG1742	UPF0060 membrane protein
OKW85_RS07590	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
OKW85_RS07595	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
OKW85_RS07600	COG0287	Prephenate dehydrogenase
OKW85_RS07605	COG0534	Mate efflux family protein
OKW85_RS07610	COG1013	pyruvate-flavodoxin oxidoreductase activity
OKW85_RS07615	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
OKW85_RS07615	COG0674	pyruvate-flavodoxin oxidoreductase activity
OKW85_RS07625	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
OKW85_RS07635	COG1122	ATPase activity
OKW85_RS07640	COG0203	ribosomal protein L17
OKW85_RS07645	COG0202	RNA polymerase activity
OKW85_RS07655	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
OKW85_RS07660	COG0257	Belongs to the bacterial ribosomal protein bL36 family
OKW85_RS07680	COG0201	protein transport
OKW85_RS07685	COG0200	Binds to the 23S rRNA
OKW85_RS07690	COG1841	ribosomal large subunit assembly
OKW85_RS07695	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
OKW85_RS07700	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
OKW85_RS07705	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
OKW85_RS07710	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
OKW85_RS07720	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
OKW85_RS07730	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
OKW85_RS07735	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
OKW85_RS07740	COG0255	Belongs to the universal ribosomal protein uL29 family
OKW85_RS07745	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
OKW85_RS07750	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
OKW85_RS07755	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
OKW85_RS07760	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
OKW85_RS07765	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
OKW85_RS07775	COG0088	Forms part of the polypeptide exit tunnel
OKW85_RS07780	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
OKW85_RS07785	COG0051	transcription antitermination factor activity, RNA binding
OKW85_RS07790	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
OKW85_RS07800	COG0049	tRNA binding
OKW85_RS07805	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
OKW85_RS07815	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
OKW85_RS07820	COG0085	RNA polymerase activity
OKW85_RS07825	COG1027	Aspartate ammonia-lyase
OKW85_RS07830	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
OKW85_RS07835	COG0222	ribosome binding
OKW85_RS07845	COG0081	regulation of translation
OKW85_RS07850	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
OKW85_RS07855	COG0250	Participates in transcription elongation, termination and antitermination
OKW85_RS07860	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
OKW85_RS07865	COG0267	Belongs to the bacterial ribosomal protein bL33 family
OKW85_RS07880	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
OKW85_RS07920	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
OKW85_RS07930	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
OKW85_RS07935	COG0768	penicillin binding
OKW85_RS07940	COG0617	tRNA 3'-terminal CCA addition
OKW85_RS07945	COG1760	l-serine dehydratase
OKW85_RS07950	COG1760	l-serine dehydratase
OKW85_RS07955	COG1151	hydroxylamine reductase activity
OKW85_RS07960	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
OKW85_RS08005	COG0355	proton-transporting ATP synthase activity, rotational mechanism
OKW85_RS08020	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
OKW85_RS08025	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
OKW85_RS08030	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
OKW85_RS08035	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
OKW85_RS08040	COG0356	it plays a direct role in the translocation of protons across the membrane
OKW85_RS08055	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
OKW85_RS08060	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
OKW85_RS08065	COG2848	UPF0210 protein
OKW85_RS08070	COG3830	Belongs to the UPF0237 family
OKW85_RS08075	COG0033	Phosphoglucomutase
OKW85_RS08080	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
OKW85_RS08085	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
OKW85_RS08090	COG1802	Transcriptional regulator
OKW85_RS08095	COG1115	amino acid carrier protein
OKW85_RS08105	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
OKW85_RS08115	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
OKW85_RS08120	COG0708	Exodeoxyribonuclease III
OKW85_RS08210	COG0444	Belongs to the ABC transporter superfamily
OKW85_RS08220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
OKW85_RS08225	COG0601	transmembrane transport
OKW85_RS08230	COG0531	amino acid
OKW85_RS08235	COG0165	Argininosuccinate lyase
OKW85_RS08240	COG0137	argininosuccinate synthase activity
OKW85_RS08255	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
OKW85_RS08260	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
OKW85_RS08265	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
OKW85_RS08270	COG1757	Na H antiporter
OKW85_RS08275	COG1105	Belongs to the carbohydrate kinase PfkB family
OKW85_RS08280	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
OKW85_RS08280	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
OKW85_RS08280	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
OKW85_RS08310	COG0450	alkyl hydroperoxide reductase
OKW85_RS08320	COG0504	CTP synthase activity
OKW85_RS08325	COG0018	arginyl-trna synthetase
OKW85_RS08370	COG0561	phosphatase activity
OKW85_RS08380	COG0371	Dehydrogenase
OKW85_RS08385	COG1114	Component of the transport system for branched-chain amino acids
OKW85_RS08390	COG0243	molybdopterin cofactor binding
OKW85_RS08395	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
OKW85_RS08400	COG1620	l-lactate permease
OKW85_RS08410	COG2814	Major facilitator Superfamily
OKW85_RS08430	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
OKW85_RS08440	COG4820	ethanolamine utilization protein (EutJ)
OKW85_RS08445	COG4869	propanediol catabolic process
OKW85_RS08475	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
OKW85_RS08490	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
OKW85_RS08550	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
OKW85_RS08560	COG1454	alcohol dehydrogenase
OKW85_RS08575	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
OKW85_RS08580	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
OKW85_RS08600	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
OKW85_RS08605	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
OKW85_RS08610	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
OKW85_RS08615	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
OKW85_RS08620	COG1605	Chorismate mutase
OKW85_RS08620	COG0077	Prephenate dehydratase
OKW85_RS08640	COG0710	3-dehydroquinate dehydratase activity
OKW85_RS08645	COG2814	Major facilitator Superfamily
OKW85_RS08650	COG1959	2 iron, 2 sulfur cluster binding
OKW85_RS08655	COG2252	PERMEase
OKW85_RS08680	COG1113	amino acid transport
OKW85_RS08695	COG0564	pseudouridine synthase activity
OKW85_RS08710	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
OKW85_RS08715	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
OKW85_RS08720	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
OKW85_RS08730	COG0067	glutamate synthase
OKW85_RS08730	COG0070	glutamate synthase
OKW85_RS08730	COG0069	glutamate synthase activity
OKW85_RS08735	COG0564	pseudouridine synthase activity
OKW85_RS08760	COG0656	L-ascorbic acid biosynthetic process
OKW85_RS08765	COG1687	branched-chain amino acid
OKW85_RS08770	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
OKW85_RS08775	COG1979	alcohol dehydrogenase
OKW85_RS08790	COG0778	Nitroreductase
OKW85_RS08790	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
OKW85_RS08795	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
OKW85_RS08795	COG2146	nitrite reductase [NAD(P)H] activity
OKW85_RS08805	COG1556	Lactate utilization protein
OKW85_RS08810	COG1139	Iron-sulfur cluster binding protein
OKW85_RS08815	COG0247	lactate metabolic process
OKW85_RS08825	COG3266	domain, Protein
OKW85_RS08825	COG2911	Protein conserved in bacteria
OKW85_RS08825	COG1361	Conserved repeat domain
OKW85_RS08835	COG1297	OPT oligopeptide transporter protein
OKW85_RS08900	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
OKW85_RS08920	COG1074	ATP-dependent DNA helicase activity
OKW85_RS08925	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
OKW85_RS09190	COG3209	COG3209 Rhs family protein
OKW85_RS09235	COG2217	Heavy metal translocating P-type atpase
OKW85_RS09240	COG1174	glycine betaine transport
OKW85_RS09250	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
OKW85_RS09260	COG0305	Participates in initiation and elongation during chromosome replication
OKW85_RS09265	COG0359	binds to the 23S rRNA
OKW85_RS09270	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
OKW85_RS09280	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
OKW85_RS09290	COG3152	Membrane
OKW85_RS09300	COG1116	anion transmembrane transporter activity
OKW85_RS09300	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
OKW85_RS09305	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
OKW85_RS09310	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
OKW85_RS09315	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
OKW85_RS09320	COG0586	Pfam SNARE associated Golgi protein
OKW85_RS09335	COG0515	serine threonine protein kinase
OKW85_RS09340	COG2048	Heterodisulfide reductase, subunit B
OKW85_RS09345	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
OKW85_RS09350	COG1053	succinate dehydrogenase
OKW85_RS09355	COG0745	RESPONSE REGULATOR receiver
OKW85_RS09365	COG2733	membrane
OKW85_RS09370	COG2733	membrane
OKW85_RS09380	COG1733	regulation of RNA biosynthetic process
OKW85_RS09385	COG0386	Belongs to the glutathione peroxidase family
OKW85_RS09395	COG0280	phosphate acetyltransferase
OKW85_RS09400	COG1373	ATPase (AAA superfamily
OKW85_RS09410	COG0493	'glutamate synthase
OKW85_RS09415	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
OKW85_RS09430	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
OKW85_RS09435	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
OKW85_RS09445	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
OKW85_RS09455	COG2824	Alkylphosphonate utilization operon protein PhnA
OKW85_RS09550	COG0753	catalase activity
OKW85_RS09560	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
OKW85_RS09570	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
OKW85_RS09575	COG1917	Cupin 2, conserved barrel domain protein
OKW85_RS09575	COG1396	sequence-specific DNA binding
OKW85_RS09585	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
OKW85_RS09590	COG0501	Belongs to the peptidase M48B family
OKW85_RS09610	COG0848	biopolymer transport protein
OKW85_RS09615	COG0811	peptide transport
OKW85_RS09625	COG1703	isobutyryl-CoA mutase activity
OKW85_RS09630	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
OKW85_RS09630	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
OKW85_RS09635	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
OKW85_RS09635	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
OKW85_RS09665	COG0277	FAD linked oxidase domain protein
OKW85_RS09680	COG1454	alcohol dehydrogenase
OKW85_RS09685	COG1472	Belongs to the glycosyl hydrolase 3 family
OKW85_RS09710	COG1846	Transcriptional regulator
OKW85_RS09730	COG1393	Belongs to the ArsC family
OKW85_RS09750	COG0519	Catalyzes the synthesis of GMP from XMP
OKW85_RS09815	COG3069	C4-dicarboxylate transmembrane transporter activity
OKW85_RS09820	COG2195	Cleaves the N-terminal amino acid of tripeptides
OKW85_RS09830	COG1473	amidohydrolase
OKW85_RS09835	COG3366	ferrous iron transmembrane transporter activity
OKW85_RS09840	COG0700	Nucleoside recognition
OKW85_RS09895	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
OKW85_RS09920	COG1472	Belongs to the glycosyl hydrolase 3 family
OKW85_RS09950	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
OKW85_RS09965	COG1489	DNA binding
OKW85_RS09970	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
OKW85_RS10015	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
OKW85_RS10020	COG0739	heme binding
OKW85_RS10020	COG0741	lytic transglycosylase activity
OKW85_RS10020	COG1196	nuclear chromosome segregation
OKW85_RS10030	COG1160	GTP binding
OKW85_RS10035	COG1475	DNA binding
OKW85_RS10040	COG1192	Involved in chromosome partitioning
OKW85_RS10055	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
OKW85_RS10055	COG0646	methionine synthase
OKW85_RS10075	COG0445	tRNA wobble uridine modification
OKW85_RS10080	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
OKW85_RS10085	COG1847	R3H domain protein
OKW85_RS10095	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
OKW85_RS10100	COG0594	ribonuclease P activity
OKW85_RS10105	COG0230	Belongs to the bacterial ribosomal protein bL34 family
OKW85_RS10110	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
OKW85_RS10125	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
OKW85_RS10155	COG1192	Involved in chromosome partitioning
OKW85_RS10220	COG0739	heme binding
OKW85_RS10240	COG3451	type IV secretory pathway VirB4
OKW85_RS10255	COG4962	Type ii secretion system protein e