locus-tag class description HZ306_RS00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) HZ306_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HZ306_RS00020 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HZ306_RS00035 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HZ306_RS00040 ENOG4108IQI permease HZ306_RS00050 ENOG4107Z6X Transcriptional regulator HZ306_RS00070 ENOG4105DJY efflux transporter, rnd family, mfp subunit HZ306_RS00105 ENOG4108PQP glycosyl transferase group 1 HZ306_RS00120 ENOG4105D3Q Sugar transferase HZ306_RS00125 ENOG4108TGC Acyltransferase HZ306_RS00130 ENOG4105D5D udp-galactopyranose mutase HZ306_RS00145 ENOG4108KMV Glycosyl transferase (Group 1 HZ306_RS00155 ENOG4105ER6 polysaccharide biosynthesis protein HZ306_RS00210 ENOG4106R49 Methyltransferase HZ306_RS00250 ENOG4105EUB pirin domain protein HZ306_RS00265 ENOG4105D0M Protease HtpX homolog HZ306_RS00285 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) HZ306_RS00295 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HZ306_RS00300 ENOG4105EHG Permease protein HZ306_RS00305 ENOG4105E0A ABC, transporter HZ306_RS00320 ENOG4105CTK cobaltochelatase, cobn subunit HZ306_RS00330 ENOG4105D05 Receptor HZ306_RS00335 ENOG4105CHM Aminotransferase HZ306_RS00340 ENOG4105WAB arsR family transcriptional regulator HZ306_RS00345 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HZ306_RS00350 ENOG41090P5 ferredoxin-like protein HZ306_RS00355 ENOG4105BZJ Electron transfer flavoprotein HZ306_RS00360 ENOG4105C10 Electron transfer flavoprotein HZ306_RS00365 ENOG4105EMU Dehydrogenase HZ306_RS00385 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HZ306_RS00390 ENOG4107RRN ABC transporter substrate-binding protein HZ306_RS00395 ENOG4105C3U ABC transporter HZ306_RS00400 ENOG4108JQ7 (ABC) transporter HZ306_RS00465 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HZ306_RS00470 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HZ306_RS00475 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HZ306_RS00480 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HZ306_RS00490 ENOG4105RNB HZ306_RS00510 ENOG4105QZY s-layer domain protein HZ306_RS00535 ENOG4105ZU5 s-layer protein HZ306_RS00545 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HZ306_RS00550 ENOG4105CNN ABC, transporter HZ306_RS00555 ENOG4105C2J ABC transporter HZ306_RS00560 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) HZ306_RS00565 ENOG4108RVA ribokinase HZ306_RS00585 ENOG4105DZR Type I site-specific deoxyribonuclease HZ306_RS00600 ENOG4108JJB ABC transporter HZ306_RS00605 ENOG4108JJB ABC transporter HZ306_RS00620 ENOG4108W76 histidinol phosphate phosphatase hisj family HZ306_RS00660 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) HZ306_RS00670 ENOG4105C6T cysteine synthase HZ306_RS00675 ENOG4105D7W serine acetyltransferase HZ306_RS00690 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) HZ306_RS00700 ENOG4105D1Q UPF0246 protein HZ306_RS00705 ENOG4107QW8 radical SAM domain protein HZ306_RS00715 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HZ306_RS00720 ENOG4108R66 Conserved Protein HZ306_RS00725 ENOG4108UZ3 Transporter HZ306_RS00775 ENOG4105DDQ anthranilate synthase HZ306_RS00790 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HZ306_RS00795 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) HZ306_RS00825 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HZ306_RS00850 ENOG4107R0W ABC transporter HZ306_RS00865 ENOG410667J hydrolase HZ306_RS00875 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HZ306_RS00930 ENOG4105SUU thioesterase domain HZ306_RS00935 ENOG4105CC5 ABC transporter HZ306_RS00940 ENOG4107RPQ ABC transporter HZ306_RS00945 ENOG4105DIK (ABC) transporter HZ306_RS00950 ENOG4107SIG periplasmic solute binding protein HZ306_RS00960 ENOG4105WQ5 TonB family HZ306_RS00980 ENOG4105CJG carbon-monoxide dehydrogenase catalytic subunit HZ306_RS00985 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein HZ306_RS01000 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) HZ306_RS01005 ENOG4107VRP DNA repair exonuclease HZ306_RS01010 ENOG4106D4I domain protein HZ306_RS01015 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) HZ306_RS01020 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HZ306_RS01025 ENOG4105C1Q protoporphyrinogen oxidase HZ306_RS01030 ENOG4107JTW chlorite dismutase HZ306_RS01035 ENOG4105DQQ Major facilitator superfamily MFS_1 HZ306_RS01040 ENOG4107V6Q Cyclic nucleotide-binding domain HZ306_RS01050 ENOG4108IUE nitrate reductase beta subunit HZ306_RS01055 ENOG4105R3A Nitrate reductase HZ306_RS01070 ENOG4105ZU5 s-layer protein HZ306_RS01080 ENOG4105C6X Major Facilitator HZ306_RS01085 ENOG4105DZ2 Transcriptional regulator HZ306_RS01095 ENOG4105HMI Membrane HZ306_RS01100 ENOG4108V2W Carbonate dehydratase HZ306_RS01105 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HZ306_RS01110 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HZ306_RS01115 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HZ306_RS01125 ENOG4105FAV ABC, transporter HZ306_RS01130 ENOG4105FDK ABC transporter HZ306_RS01135 ENOG4105DSE periplasmic solute binding protein HZ306_RS01140 ENOG4105MZU cell filamentation protein HZ306_RS01190 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HZ306_RS01195 ENOG4105C5I Dehydrogenase HZ306_RS01200 ENOG4105F1A Pyruvate formate-lyase HZ306_RS01205 ENOG4105C6N Formate acetyltransferase HZ306_RS01225 ENOG4108UMI ABC transporter, permease HZ306_RS01230 ENOG4105D01 (LipO)protein HZ306_RS01235 ENOG4105BZ1 (ABC) transporter HZ306_RS01245 ENOG4107QPK )-transporter HZ306_RS01260 ENOG4105C28 cystathionine HZ306_RS01265 ENOG4105C87 Aminotransferase class I and II HZ306_RS01295 ENOG4108PJD permease HZ306_RS01300 ENOG4105CKI cobalamin synthesis protein HZ306_RS01305 ENOG4105CIN aminoacyl-histidine dipeptidase HZ306_RS01310 ENOG4105DAP Nicotinate phosphoribosyltransferase HZ306_RS01320 ENOG4107RB3 L-asparaginase HZ306_RS01330 ENOG4105D64 Mechanosensitive ion channel HZ306_RS01335 ENOG4105DZ1 carboxypeptidase HZ306_RS01345 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HZ306_RS01355 ENOG4108XHQ (2Fe-2S)-binding domain protein HZ306_RS01360 ENOG4105C7W Xanthine dehydrogenase HZ306_RS01380 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family HZ306_RS01390 ENOG4105C8B TIGR00159 family HZ306_RS01395 ENOG4107U5W ybbr family HZ306_RS01400 ENOG4105DZ0 fad dependent oxidoreductase HZ306_RS01405 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) HZ306_RS01430 ENOG4108QDQ Ubiquinol-cytochrome C chaperone HZ306_RS01435 ENOG4108PZQ Inner membrane protein YeeR HZ306_RS01445 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HZ306_RS01450 ENOG4105C31 Tryptophanyl-tRNA synthetase HZ306_RS01460 ENOG4107R0W ABC transporter HZ306_RS01465 ENOG4105E5Q amino acid AbC transporter HZ306_RS01485 ENOG4107YCR Transcriptional regulator, ARSR family HZ306_RS01495 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HZ306_RS01500 ENOG4105E0C molybdate abc transporter HZ306_RS01505 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) HZ306_RS01530 ENOG4108RAC Rubrerythrin HZ306_RS01540 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) HZ306_RS01555 ENOG4108RCM Nitroreductase HZ306_RS01560 ENOG4107BMA Transglycosylase associated protein HZ306_RS01570 ENOG4105C3G gtp-binding protein HZ306_RS01595 ENOG4105C2C drug resistance transporter, Bcr CflA HZ306_RS01600 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) HZ306_RS01605 ENOG4108UUM single-stranded DNA-binding protein HZ306_RS01610 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HZ306_RS01625 ENOG4105CGC Nitrogenase cofactor biosynthesis protein NifB HZ306_RS01645 ENOG4108RS6 transposase HZ306_RS01650 ENOG4105VUF Transcriptional regulator HZ306_RS01655 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HZ306_RS01670 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) HZ306_RS01675 ENOG4105CNI cell division protein FtsW HZ306_RS01720 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) HZ306_RS01735 ENOG4108J5H Homocysteine s-methyltransferase HZ306_RS01750 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii HZ306_RS01755 ENOG4108M0I Transcriptional regulator HZ306_RS01760 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) HZ306_RS01775 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HZ306_RS01780 ENOG4105C8V SAICAR synthetase HZ306_RS01785 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase HZ306_RS01790 ENOG4105CXB phosphoribosylaminoimidazole synthetase HZ306_RS01795 ENOG4108V3E phosphoribosylglycinamide formyltransferase HZ306_RS01805 ENOG4105C12 Phosphoribosylglycinamide synthetase HZ306_RS01810 ENOG4105E4F Isochorismate synthase HZ306_RS01815 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) HZ306_RS01820 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) HZ306_RS01825 ENOG4108IPT Naphthoate synthase HZ306_RS01830 ENOG4105CEY Amp-dependent synthetase and ligase HZ306_RS01835 ENOG4105DTQ mandelate racemase muconate lactonizing HZ306_RS01880 ENOG4105CXY transporter HZ306_RS01905 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HZ306_RS01910 ENOG4107BJW polysaccharide deacetylase HZ306_RS01915 ENOG4108HQ0 Exopolysaccharide biosynthesis protein HZ306_RS01925 ENOG4105XA0 heptosyltransferase ii HZ306_RS01935 ENOG4107QSA Oxaloacetate decarboxylase HZ306_RS01950 ENOG4105C0H protease HZ306_RS01970 ENOG4107XPQ Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) HZ306_RS01975 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) HZ306_RS01980 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) HZ306_RS02000 ENOG4105D01 (LipO)protein HZ306_RS02005 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HZ306_RS02020 ENOG4105KME endoribonuclease L-psp HZ306_RS02025 ENOG4105CEM UPF0597 protein HZ306_RS02030 ENOG4105EU0 Major facilitator Superfamily HZ306_RS02040 ENOG4108Z6B deaminase HZ306_RS02045 ENOG4105EN6 Membrane HZ306_RS02060 ENOG4105F0I Aminotransferase HZ306_RS02065 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HZ306_RS02070 ENOG4108UMI ABC transporter, permease HZ306_RS02075 ENOG4105KGF protein, YerC YecD HZ306_RS02080 ENOG4105EJ9 Membrane HZ306_RS02085 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr HZ306_RS02105 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) HZ306_RS02120 ENOG4107RID 5-oxoprolinase (ATP-hydrolyzing) HZ306_RS02125 ENOG4105DGU Histone deacetylase HZ306_RS02130 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) HZ306_RS02150 ENOG4105C6K Malic enzyme HZ306_RS02185 ENOG4105E7W lamb ycsf family protein HZ306_RS02190 ENOG4105C5A transporter HZ306_RS02195 ENOG4105P4J Allophanate hydrolase, subunit 1 HZ306_RS02215 ENOG4105UQX Mate efflux family protein HZ306_RS02220 ENOG4108ZG0 Ompa motb domain protein HZ306_RS02225 ENOG4105C02 permease HZ306_RS02245 ENOG4108FUT Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) HZ306_RS02250 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HZ306_RS02310 ENOG4108JA2 transcriptioN-repair coupling factor HZ306_RS02315 ENOG4105CKP Polysaccharide Biosynthesis Protein HZ306_RS02320 ENOG4105DXN mazG family HZ306_RS02325 ENOG4105K70 DNA-binding protein HZ306_RS02340 ENOG4105C5H ABC transporter HZ306_RS02345 ENOG4107QHI -hydrogenase HZ306_RS02355 ENOG4105CJ3 phosphate transporter HZ306_RS02370 ENOG4105E0A ABC, transporter HZ306_RS02375 ENOG4105S6R Iron-hydroxamate transporter permease subunit HZ306_RS02400 ENOG4105FTV AraC Family Transcriptional Regulator HZ306_RS02405 ENOG4105D05 Receptor HZ306_RS02415 ENOG4109015 Biopolymer transport protein exbD tolR HZ306_RS02430 ENOG4105D4P Coproporphyrinogen iii oxidase HZ306_RS02435 ENOG4108MGF sugar kinase HZ306_RS02440 ENOG4105CZN Potassium uptake protein HZ306_RS02445 ENOG4107ZYR domain protein HZ306_RS02465 ENOG4107WCI zn-dependent hydrolase of the beta-lactamase fold-like protein HZ306_RS02475 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HZ306_RS02480 ENOG4105WZB UPF0342 protein HZ306_RS02490 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HZ306_RS02495 ENOG4105CI3 gtp-binding protein typa HZ306_RS02545 ENOG4105C7K acetolactate synthase HZ306_RS02550 ENOG4108ZP8 Acetolactate synthase small subunit HZ306_RS02555 ENOG4108V2W Carbonate dehydratase HZ306_RS02570 ENOG4105CH2 amidohydrolase HZ306_RS02580 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HZ306_RS02585 ENOG4105CAS nag kinase HZ306_RS02590 ENOG4105C8Y Acetylornithine aminotransferase HZ306_RS02605 ENOG4105CEE C4-dicarboxylate transporter HZ306_RS02615 ENOG4106UW1 Major Facilitator superfamily HZ306_RS02620 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) HZ306_RS02625 ENOG4105N67 Proton-coupled thiamine transporter YuaJ HZ306_RS02645 ENOG4108WZA zeta toxin HZ306_RS02650 ENOG41075H3 AraC family transcriptional regulator HZ306_RS02660 ENOG4105W4W Transcriptional regulator HZ306_RS02665 ENOG4106DSS Tartrate dehydratase subunit alpha HZ306_RS02670 ENOG4107GFK fumarate HZ306_RS02675 ENOG4105C8P )-transporter HZ306_RS02680 ENOG4105CKU formyltetrahydrofolate synthetase HZ306_RS02690 ENOG4105C2W permease HZ306_RS02700 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HZ306_RS02720 ENOG4105EZR dyp-type peroxidase family protein HZ306_RS02725 ENOG4107QID Threonine synthase HZ306_RS02735 ENOG4105CPB ATP-dependent endonuclease of the OLD family HZ306_RS02740 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) HZ306_RS02745 ENOG4105C5I Dehydrogenase HZ306_RS02765 ENOG4108Z29 Flavodoxin HZ306_RS02775 ENOG4107RCH Diaminopropionate ammonia-lyase HZ306_RS02780 ENOG4107S4Y M20 DapE family protein YgeY HZ306_RS02785 ENOG4105IW6 Carbamoyltransferase HZ306_RS02790 ENOG4105C5B carbamate kinase HZ306_RS02795 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) HZ306_RS02800 ENOG4105BZ8 glutamate synthase HZ306_RS02815 ENOG4105C2W permease HZ306_RS02820 ENOG4107T6J Ribulose-1,5-bisphosphate carboxylase oxygenase large subunit HZ306_RS02825 ENOG4105Q2H domain protein HZ306_RS02830 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) HZ306_RS02835 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HZ306_RS02840 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation HZ306_RS02845 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HZ306_RS02850 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HZ306_RS02855 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HZ306_RS02860 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) HZ306_RS02870 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HZ306_RS02875 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HZ306_RS02880 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HZ306_RS02890 ENOG4105CYC Transferase HZ306_RS02910 ENOG4108ZVT methylmalonyl-coA epimerase HZ306_RS02930 ENOG4105PV1 biotin lipoyl attachment domaiN-containing protein HZ306_RS02935 ENOG4105D9Q decarboxylase (Beta subunit) HZ306_RS02945 ENOG4107QWE )-transporter HZ306_RS02950 ENOG4107QWE )-transporter HZ306_RS02965 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) HZ306_RS02970 ENOG4105C34 Pseudouridine synthase HZ306_RS03000 ENOG4108Z03 MAF-like protein HZ306_RS03005 ENOG4105W5Q DNA repair protein (RadC HZ306_RS03010 ENOG4105DFF Rod shape-determining protein mreb HZ306_RS03025 ENOG4105CJN penicillin-binding protein HZ306_RS03035 ENOG4105CNI cell division protein FtsW HZ306_RS03050 ENOG4105C03 ribonuclease HZ306_RS03060 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) HZ306_RS03070 ENOG4105K46 50S ribosomal protein l27 HZ306_RS03075 ENOG41083J0 (ABC) transporter HZ306_RS03080 ENOG4105C4B ABC transporter, permease HZ306_RS03085 ENOG4107QW8 radical SAM domain protein HZ306_RS03090 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HZ306_RS03095 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HZ306_RS03100 ENOG4107VMB Beta-lactamase domain protein HZ306_RS03105 ENOG4105I3K Ferric uptake regulator, Fur family HZ306_RS03110 ENOG4105D4P Coproporphyrinogen iii oxidase HZ306_RS03120 ENOG4105C9M aspartyl-trna synthetase HZ306_RS03135 ENOG4105CNU cell division protein FtsK HZ306_RS03155 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) HZ306_RS03160 ENOG4105CEV competence damage-inducible protein HZ306_RS03165 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) HZ306_RS03170 ENOG410902V Modulates RecA activity (By similarity) HZ306_RS03175 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) HZ306_RS03180 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HZ306_RS03185 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HZ306_RS03195 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HZ306_RS03215 ENOG4105EGD dinuclear metal center protein, YbgI family HZ306_RS03225 ENOG4105K63 Thioredoxin HZ306_RS03230 ENOG4105E3S small subunit HZ306_RS03245 ENOG4108USZ hydrogenase HZ306_RS03255 ENOG4105CKK Glycosyl transferase, family 2 HZ306_RS03275 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) HZ306_RS03280 ENOG41068XD UPF0473 protein HZ306_RS03295 ENOG4105CFP Peptidase U32 HZ306_RS03310 ENOG4105C22 threonyL-tRNA synthetase HZ306_RS03315 ENOG4107RGD Major Facilitator superfamily HZ306_RS03320 ENOG4107QPK )-transporter HZ306_RS03325 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HZ306_RS03330 ENOG4105VJV 50s ribosomal protein L35 HZ306_RS03370 ENOG4105DB4 HZ306_RS03420 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HZ306_RS03435 ENOG4108Z86 Glutamine amidotransferase HZ306_RS03450 ENOG4105CKP Polysaccharide Biosynthesis Protein HZ306_RS03455 ENOG4105D2N Aldolase HZ306_RS03460 ENOG4105EMS pseudouridine synthase HZ306_RS03475 ENOG4108VPT UPF0234 protein HZ306_RS03480 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) HZ306_RS03490 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase HZ306_RS03495 ENOG4105CIA precorrin-4 C(11)-methyltransferase HZ306_RS03500 ENOG4108P62 biosynthesis protein (CbiG) HZ306_RS03505 ENOG4105E4R Precorrin-3B C17-methyltransferase HZ306_RS03510 ENOG4105QUC reductase HZ306_RS03515 ENOG41081F0 Precorrin-8x methylmutase HZ306_RS03520 ENOG4108U1V ABC transporter, permease HZ306_RS03525 ENOG4105E0A ABC, transporter HZ306_RS03535 ENOG4107PPM cobalt chelatase HZ306_RS03545 ENOG4107PPM cobalt chelatase HZ306_RS03550 ENOG4105DVK Precorrin-2 c20-methyltransferase HZ306_RS03555 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HZ306_RS03565 ENOG4108YZ8 Superoxide reductase HZ306_RS03585 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) HZ306_RS03595 ENOG4105K63 Thioredoxin HZ306_RS03605 ENOG4108V6E Cell division protein mraZ HZ306_RS03610 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) HZ306_RS03620 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HZ306_RS03625 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) HZ306_RS03630 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) HZ306_RS03640 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HZ306_RS03645 ENOG4105DFU Cell wall formation (By similarity) HZ306_RS03650 ENOG4105CPF Cell wall formation (By similarity) HZ306_RS03665 ENOG4105K67 small basic protein HZ306_RS03670 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HZ306_RS03690 ENOG4105CSM endonuclease III HZ306_RS03705 ENOG41082DI 50s ribosomal protein l31 HZ306_RS03710 ENOG4105CBJ Metal-dependent enzyme HZ306_RS03720 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HZ306_RS03725 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HZ306_RS03730 ENOG4107WAU Protein tyrosine phosphatase HZ306_RS03735 ENOG4108YZG isomerase HZ306_RS03740 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HZ306_RS03760 ENOG4105BZA Phosphoglycerate kinase HZ306_RS03765 ENOG4105CP7 Triose-phosphate isomerase HZ306_RS03775 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) HZ306_RS03780 ENOG4107QHF type ii secretion system protein e HZ306_RS03785 ENOG4105CZX twitching motility protein HZ306_RS03790 ENOG4105D7Q type ii secretion system HZ306_RS03795 ENOG4106855 Competence protein HZ306_RS03840 ENOG4107ZC0 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HZ306_RS03850 ENOG4105DJY efflux transporter, rnd family, mfp subunit HZ306_RS03855 ENOG4105C19 ABC transporter HZ306_RS03860 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HZ306_RS03870 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) HZ306_RS03875 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HZ306_RS03880 ENOG4105CFP Peptidase U32 HZ306_RS03885 ENOG4105C98 muts2 protein HZ306_RS03890 ENOG4108JQC penicillin-binding protein 1A HZ306_RS03895 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HZ306_RS03915 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) HZ306_RS03920 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein HZ306_RS03935 ENOG41069HH 4-oxalocrotonate tautomerase HZ306_RS03940 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HZ306_RS03950 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme HZ306_RS03985 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HZ306_RS03990 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 HZ306_RS03995 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HZ306_RS04005 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HZ306_RS04010 ENOG4105K8N protein family UPF0079, ATPase HZ306_RS04015 ENOG41072GX Peptidase M22 Glycoprotease HZ306_RS04040 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) HZ306_RS04045 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) HZ306_RS04060 ENOG4105C3K feS assembly ATPase SufC HZ306_RS04075 ENOG4105C9B Cysteine desulfurase HZ306_RS04080 ENOG4107YH3 SUF system FeS assembly protein, NifU family HZ306_RS04100 ENOG4108Z0C Uvrb UvrC protein HZ306_RS04105 ENOG41066A3 ATP guanido phosphotransferase HZ306_RS04115 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HZ306_RS04120 ENOG4105CTP PilT protein domain protein HZ306_RS04125 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) HZ306_RS04130 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HZ306_RS04135 ENOG4105C09 Bile acid HZ306_RS04140 ENOG4105C8N cysteinyl-tRNA synthetase HZ306_RS04145 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) HZ306_RS04150 ENOG4105C2N RNA methyltransferase TrmH family group 3 HZ306_RS04160 ENOG4105QIV RNA polymerase HZ306_RS04165 ENOG4105XZU Preprotein translocase, subunit SecG HZ306_RS04170 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HZ306_RS04175 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) HZ306_RS04185 ENOG4108W8G Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP (By similarity) HZ306_RS04210 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase HZ306_RS04215 ENOG4105C4R Atp-dependent dna helicase HZ306_RS04220 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HZ306_RS04240 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HZ306_RS04245 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HZ306_RS04260 ENOG4105N5T Radical SAM Protein HZ306_RS04265 ENOG4105C9A Phoh family HZ306_RS04275 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HZ306_RS04280 ENOG4105C37 (CBS) domain HZ306_RS04315 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit HZ306_RS04320 ENOG4105C38 Glycyl-tRNA synthetase beta subunit HZ306_RS04330 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) HZ306_RS04345 ENOG4105VFF UPF0102 protein HZ306_RS04350 ENOG4105C0P Mg chelatase subunit ChlI HZ306_RS04355 ENOG4105C79 DNA protecting protein DprA HZ306_RS04360 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HZ306_RS04365 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) HZ306_RS04370 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) HZ306_RS04375 ENOG4105VRS hydrolase family 18 HZ306_RS04385 ENOG4107YWA deoxycytidylate deaminase HZ306_RS04395 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein HZ306_RS04410 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) HZ306_RS04425 ENOG4105C7K acetolactate synthase HZ306_RS04430 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HZ306_RS04435 ENOG4108R6K riboflavin synthase, subunit alpha HZ306_RS04440 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HZ306_RS04450 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) HZ306_RS04455 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) HZ306_RS04460 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) HZ306_RS04465 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) HZ306_RS04470 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) HZ306_RS04480 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HZ306_RS04510 ENOG41073R8 VanW family HZ306_RS04525 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HZ306_RS04530 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HZ306_RS04535 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HZ306_RS04540 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) HZ306_RS04555 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HZ306_RS04560 ENOG4105DX0 Hemolysin A HZ306_RS04575 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HZ306_RS04585 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HZ306_RS04590 ENOG4107YIM Involved in the transcription termination process (By similarity) HZ306_RS04605 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HZ306_RS04610 ENOG4105DC7 peptidase M24 HZ306_RS04620 ENOG4105CVJ phosphoglycerate mutase HZ306_RS04625 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HZ306_RS04630 ENOG4105JZC GHMP kinase HZ306_RS04640 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) HZ306_RS04645 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HZ306_RS04665 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) HZ306_RS04670 ENOG4105D0M Protease HtpX homolog HZ306_RS04675 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) HZ306_RS04680 ENOG4105D6E homoserine dehydrogenase HZ306_RS04685 ENOG41090I5 UPF0735 ACT domain-containing protein HZ306_RS04695 ENOG410901P UPF0249 protein HZ306_RS04700 ENOG4108RWN rrna methyltransferase HZ306_RS04705 ENOG4105BZ1 (ABC) transporter HZ306_RS04710 ENOG4105BZ1 (ABC) transporter HZ306_RS04715 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HZ306_RS04730 ENOG4105KTH gatB Yqey HZ306_RS04735 ENOG4105VCC 30S ribosomal protein S21 HZ306_RS04740 ENOG4107YU2 histidine triad (hIT) protein HZ306_RS04745 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HZ306_RS04750 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HZ306_RS04755 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) HZ306_RS04760 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HZ306_RS04765 ENOG4105CFG Acts as a chaperone (By similarity) HZ306_RS04785 ENOG4105CSA Coproporphyrinogen iii oxidase HZ306_RS04790 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) HZ306_RS04795 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) HZ306_RS04800 ENOG4105CXI aluminum resistance protein HZ306_RS04805 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) HZ306_RS04810 ENOG4107YX5 Pfam:DUF548 HZ306_RS04815 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) HZ306_RS04840 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HZ306_RS04845 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) HZ306_RS04850 ENOG4105DZP Membrane-associated zinc metalloprotease HZ306_RS04855 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HZ306_RS04860 ENOG4105KNE Phosphatidate cytidylyltransferase HZ306_RS04875 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) HZ306_RS04880 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HZ306_RS04885 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) HZ306_RS04890 ENOG4105CE9 30S ribosomal protein S2 HZ306_RS04895 ENOG4105DJV ribulose-phosphate 3-epimerase HZ306_RS04900 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HZ306_RS04905 ENOG4105D9P serine threonine protein kinase HZ306_RS04910 ENOG4108ZF3 Phosphatase HZ306_RS04915 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs HZ306_RS04930 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) HZ306_RS04935 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HZ306_RS04940 ENOG4105C25 Primosomal protein n' HZ306_RS04945 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HZ306_RS04950 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HZ306_RS04955 ENOG41084KE Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) HZ306_RS04960 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HZ306_RS04965 ENOG4105KC4 UPF0296 protein HZ306_RS04970 ENOG4105DSJ YicC domain protein HZ306_RS04990 ENOG4106H78 methyltransferase HZ306_RS04995 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HZ306_RS05000 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) HZ306_RS05005 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) HZ306_RS05010 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HZ306_RS05020 ENOG4105CAT Cytidine monophosphate kinase HZ306_RS05025 ENOG4105CBX hi0933 family HZ306_RS05030 ENOG4105FE9 pseudouridine synthase HZ306_RS05035 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) HZ306_RS05040 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) HZ306_RS05050 ENOG4105EWC Purine nucleoside phosphorylase HZ306_RS05080 ENOG4107VMB Beta-lactamase domain protein HZ306_RS05085 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HZ306_RS05090 ENOG4105C1A potassium transporter peripheral membrane HZ306_RS05095 ENOG4105QNR S1 RNA binding domain protein HZ306_RS05100 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) HZ306_RS05105 ENOG4108KGH TRANSCRIPTIONal HZ306_RS05110 ENOG4108WF2 Metal Dependent Phosphohydrolase HZ306_RS05115 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) HZ306_RS05120 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) HZ306_RS05125 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HZ306_RS05135 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HZ306_RS05140 ENOG4105CN1 protease HZ306_RS05145 ENOG4105DR5 peptidase HZ306_RS05150 ENOG4105CRP Part of the ABC transporter FtsEX involved in HZ306_RS05155 ENOG4105CAK Cell division ATP-binding protein ftsE HZ306_RS05160 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HZ306_RS05165 ENOG4108HHA Transketolase HZ306_RS05190 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HZ306_RS05200 ENOG4105VEQ Cold shock protein HZ306_RS05210 ENOG4105E5Q amino acid AbC transporter HZ306_RS05215 ENOG4106PMH Extracellular solute-binding protein family 3 HZ306_RS05220 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HZ306_RS05225 ENOG4105MJ2 Competence protein HZ306_RS05230 ENOG4105C7H Helicase, RecD TraA family HZ306_RS05240 ENOG4105DTN riboflavin biosynthesis protein ribF HZ306_RS05255 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) HZ306_RS05260 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) HZ306_RS05260 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) HZ306_RS05265 ENOG4105VHM ribosomal protein HZ306_RS05275 ENOG4105CHV Transcription elongation factor NusA HZ306_RS05290 ENOG4107SC1 transglycosylase HZ306_RS05295 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HZ306_RS05300 ENOG4105C2M dna polymerase I HZ306_RS05315 ENOG4108RS6 transposase HZ306_RS05320 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) HZ306_RS05330 ENOG4108RS6 transposase HZ306_RS05335 ENOG4108RS6 transposase HZ306_RS05340 ENOG4107Z0P This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HZ306_RS05345 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) HZ306_RS05350 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) HZ306_RS05355 ENOG4105D5T phosphonate abc transporter HZ306_RS05360 ENOG4105C7J ABC transporter, permease HZ306_RS05380 ENOG4105DFM M18 family aminopeptidase HZ306_RS05385 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) HZ306_RS05395 ENOG4105XA0 heptosyltransferase ii HZ306_RS05400 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HZ306_RS05405 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) HZ306_RS05410 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) HZ306_RS05415 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) HZ306_RS05425 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) HZ306_RS05430 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) HZ306_RS05435 ENOG4105DFM M18 family aminopeptidase HZ306_RS05440 ENOG4107QPK )-transporter HZ306_RS05450 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HZ306_RS05465 ENOG4105CM2 brancheD-chain amino acid aminotransferase HZ306_RS05475 ENOG4105ERH Fumarylacetoacetate hydrolase HZ306_RS05560 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HZ306_RS05565 ENOG4108ZCF integral membrane protein HZ306_RS05570 ENOG4108ZCF integral membrane protein HZ306_RS05575 ENOG4107QMU Mate efflux family protein HZ306_RS05585 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) HZ306_RS05590 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HZ306_RS05595 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HZ306_RS05605 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HZ306_RS05610 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) HZ306_RS05615 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HZ306_RS05620 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) HZ306_RS05625 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HZ306_RS05630 ENOG4105EA8 2-Nitropropane dioxygenase HZ306_RS05635 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HZ306_RS05640 ENOG4105CHR reductase HZ306_RS05645 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HZ306_RS05650 ENOG4105EA8 2-Nitropropane dioxygenase HZ306_RS05655 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HZ306_RS05660 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) HZ306_RS05670 ENOG41067VY 50S ribosomal protein L32 HZ306_RS05680 ENOG4105VCQ rubredoxin HZ306_RS05700 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) HZ306_RS05705 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase HZ306_RS05765 ENOG4105KPE licD family HZ306_RS05775 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HZ306_RS05785 ENOG4105D75 Capsular exopolysaccharide family HZ306_RS05800 ENOG4108IV0 ABC, transporter HZ306_RS05805 ENOG4105C0Z ABC transporter HZ306_RS05810 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HZ306_RS05815 ENOG4105C32 Amino acid ABC transporter (Permease) HZ306_RS05820 ENOG4105CP9 extracellular ligand-binding receptor HZ306_RS05825 ENOG4105C5H ABC transporter HZ306_RS05830 ENOG4105GVR general secretion pathway protein D HZ306_RS05845 ENOG4105CMR udp-glucose 4-epimerase HZ306_RS05850 ENOG4107QP8 phosphohexose isomerase HZ306_RS05860 ENOG4105C1B dTDP-glucose 4-6-dehydratase HZ306_RS05870 ENOG4108Z66 YbaK ebsC protein HZ306_RS05880 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HZ306_RS05890 ENOG4105VKD bioY protein HZ306_RS05925 ENOG4105CQS hydrogenase expression formation protein HypD HZ306_RS05940 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs HZ306_RS05980 ENOG4105CE1 Ferrous iron transport protein b HZ306_RS05990 ENOG4105C1J atp-dependent rna helicase HZ306_RS05995 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HZ306_RS06000 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) HZ306_RS06005 ENOG4105D6U Sodium Glutamate Symporter HZ306_RS06010 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HZ306_RS06015 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) HZ306_RS06020 ENOG4107R11 Transcriptional regulator HZ306_RS06030 ENOG4108F19 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HZ306_RS06035 ENOG41069ER domain protein HZ306_RS06040 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HZ306_RS06055 ENOG4105F8V Hydrolase, tatD family HZ306_RS06060 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HZ306_RS06065 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HZ306_RS06075 ENOG4105MA4 psp1 domain protein HZ306_RS06080 ENOG4107QMP dna polymerase iii subunits gamma and tau HZ306_RS06085 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) HZ306_RS06090 ENOG4105CXN decarboxylase HZ306_RS06095 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) HZ306_RS06105 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HZ306_RS06110 ENOG4105DFT pur operon repressor HZ306_RS06115 ENOG41069ER domain protein HZ306_RS06120 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HZ306_RS06125 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HZ306_RS06140 ENOG4105X1Q TOBE domain protein HZ306_RS06165 ENOG4107SBW Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HZ306_RS06170 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HZ306_RS06180 ENOG4105VIE preprotein translocase, subunit YajC HZ306_RS06185 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) HZ306_RS06195 ENOG4105JFG SpoIID LytB domain protein HZ306_RS06205 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) HZ306_RS06210 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) HZ306_RS06220 ENOG4108WTY tRNA (Guanine-N(1)-)-methyltransferase HZ306_RS06245 ENOG4105K4T epimerase HZ306_RS06250 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) HZ306_RS06255 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) HZ306_RS06270 ENOG4105K5M 30s ribosomal protein S16 HZ306_RS06285 ENOG4107QN2 dihydrolipoyl dehydrogenase HZ306_RS06295 ENOG4105C59 p-type ATPase HZ306_RS06300 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HZ306_RS06310 ENOG4108KSA LysR family transcriptional regulator HZ306_RS06315 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) HZ306_RS06320 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) HZ306_RS06335 ENOG4105CD3 dihydroorotase HZ306_RS06340 ENOG4105CXT aspartate transcarbamylase HZ306_RS06350 ENOG4105CIE May be required for sporulation (By similarity) HZ306_RS06365 ENOG410667J hydrolase HZ306_RS06370 ENOG4105ZU5 s-layer protein HZ306_RS06375 ENOG4105ZU5 s-layer protein HZ306_RS06380 ENOG4105C3F Signal peptidase i HZ306_RS06385 ENOG4108JYZ YitT family HZ306_RS06395 ENOG4108R0D protein with myosin-like HZ306_RS06405 ENOG4108IUZ ABC transporter HZ306_RS06410 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) HZ306_RS06430 ENOG4105C2X Arabinose 5-phosphate isomerase HZ306_RS06435 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase HZ306_RS06440 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) HZ306_RS06445 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) HZ306_RS06450 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase HZ306_RS06455 ENOG4105BZ1 (ABC) transporter HZ306_RS06460 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HZ306_RS06470 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HZ306_RS06475 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) HZ306_RS06480 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HZ306_RS06485 ENOG4105D1S lipid A biosynthesis HZ306_RS06490 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HZ306_RS06530 ENOG4105DHJ ABC, transporter HZ306_RS06560 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HZ306_RS06565 ENOG4105CBT Fructose-1,6-bisphosphatase HZ306_RS06570 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HZ306_RS06585 ENOG4107QUY Guanine deaminase HZ306_RS06590 ENOG4105CXN decarboxylase HZ306_RS06595 ENOG4105CRK lysyL-tRNA synthetase HZ306_RS06605 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HZ306_RS06610 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) HZ306_RS06625 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HZ306_RS06635 ENOG4107THF Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HZ306_RS06645 ENOG41060GV RNA binding s1 domain protein HZ306_RS06655 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HZ306_RS06660 ENOG4107BMA Transglycosylase associated protein HZ306_RS06670 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HZ306_RS06675 ENOG4105KRF dihydroneopterin aldolase HZ306_RS06680 ENOG4105EEI dihydropteroate synthase HZ306_RS06685 ENOG4105EUJ GTP cyclohydrolase i HZ306_RS06690 ENOG4105C5H ABC transporter HZ306_RS06700 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HZ306_RS06715 ENOG4108JQ7 (ABC) transporter HZ306_RS06725 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HZ306_RS06730 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HZ306_RS06760 ENOG4108JJ9 ABC, transporter HZ306_RS06765 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HZ306_RS06770 ENOG4105C4M (Ubiquinol oxidase) subunit I HZ306_RS06780 ENOG4105EPU Molybdenum cofactor synthesis domain protein HZ306_RS06785 ENOG4107BJW polysaccharide deacetylase HZ306_RS06830 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) HZ306_RS06840 ENOG4107ZE5 PPIases accelerate the folding of proteins HZ306_RS06845 ENOG4105CUZ uba thif-type nad fad binding protein HZ306_RS06855 ENOG4105EYH Exonuclease HZ306_RS06860 ENOG4107RFY SbcCD D subunit HZ306_RS06865 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) HZ306_RS06870 ENOG4107XWZ ferric uptake regulator HZ306_RS06875 ENOG4105C1J atp-dependent rna helicase HZ306_RS06900 ENOG4105C26 Dehydrogenase HZ306_RS06910 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) HZ306_RS06915 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) HZ306_RS06920 ENOG4105C9U ATP-dependent DNA helicase RecQ HZ306_RS06925 ENOG4105CK7 Sodium proline symporter HZ306_RS06935 ENOG4106R49 Methyltransferase HZ306_RS06945 ENOG4107RSM transcriptional regulator HZ306_RS06975 ENOG4105CHY citrate lyase, alpha HZ306_RS06980 ENOG4105CI0 Citrate lyase HZ306_RS06985 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) HZ306_RS06990 ENOG4107QPK )-transporter HZ306_RS06995 ENOG4108KAM Transcriptional regulator HZ306_RS07000 ENOG4105HFZ Membrane HZ306_RS07010 ENOG4105C0B DNA polymerase III (alpha subunit) HZ306_RS07020 ENOG4108RS6 transposase HZ306_RS07050 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HZ306_RS07055 ENOG4105D52 delta-aminolevulinic acid dehydratase HZ306_RS07060 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HZ306_RS07065 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HZ306_RS07070 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) HZ306_RS07075 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HZ306_RS07080 ENOG4105DBK s4 domain protein HZ306_RS07090 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) HZ306_RS07095 ENOG4105DFA alanine racemase domain protein HZ306_RS07105 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HZ306_RS07110 ENOG4107VMU Membrane HZ306_RS07125 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HZ306_RS07130 ENOG4105DKW ABC transporter HZ306_RS07140 ENOG4105C7K acetolactate synthase HZ306_RS07145 ENOG4105C7B Threonine dehydratase HZ306_RS07150 ENOG4105C01 Dihydroxy-acid dehydratase HZ306_RS07155 ENOG4107QPK )-transporter HZ306_RS07160 ENOG4105G2U Cupin 2, conserved barrel domain protein HZ306_RS07170 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HZ306_RS07175 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) HZ306_RS07180 ENOG4105CGU Enoyl-CoA hydratase HZ306_RS07190 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) HZ306_RS07195 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) HZ306_RS07200 ENOG4105DZ2 Transcriptional regulator HZ306_RS07205 ENOG4105KK4 UPF0060 membrane protein HZ306_RS07210 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HZ306_RS07270 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) HZ306_RS07280 ENOG4105UQX Mate efflux family protein HZ306_RS07295 ENOG4105DQU oxidoreductase, subunit beta HZ306_RS07300 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein HZ306_RS07305 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) HZ306_RS07310 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) HZ306_RS07315 ENOG4108JJB ABC transporter HZ306_RS07320 ENOG4108JJB ABC transporter HZ306_RS07325 ENOG4108ZT0 50S ribosomal protein l17 HZ306_RS07330 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HZ306_RS07335 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) HZ306_RS07345 ENOG41067V7 50S ribosomal protein L36 HZ306_RS07365 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HZ306_RS07370 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) HZ306_RS07375 ENOG4105VPB 50S ribosomal protein L30 HZ306_RS07380 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) HZ306_RS07385 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) HZ306_RS07395 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) HZ306_RS07405 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits HZ306_RS07415 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) HZ306_RS07430 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) HZ306_RS07435 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) HZ306_RS07440 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) HZ306_RS07445 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) HZ306_RS07450 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity HZ306_RS07460 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) HZ306_RS07465 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) HZ306_RS07470 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) HZ306_RS07475 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HZ306_RS07485 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) HZ306_RS07490 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) HZ306_RS07500 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HZ306_RS07505 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HZ306_RS07510 ENOG4108IJ0 Aspartate ammonia-lyase HZ306_RS07515 ENOG4107SH3 glycosyl transferase, family 39 HZ306_RS07525 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) HZ306_RS07540 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) HZ306_RS07545 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HZ306_RS07550 ENOG410683Z Preprotein translocase SecE subunit HZ306_RS07555 ENOG4105WDJ 50S ribosomal protein L33 HZ306_RS07560 ENOG4105DSQ Nitric oxide reductase HZ306_RS07565 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HZ306_RS07610 ENOG4107RSS Hydrogenase accessory protein HypB HZ306_RS07620 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HZ306_RS07625 ENOG4105CJN penicillin-binding protein HZ306_RS07630 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate HZ306_RS07635 ENOG4105EJQ L-serine dehydratase HZ306_RS07645 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) HZ306_RS07700 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) HZ306_RS07715 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) HZ306_RS07720 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HZ306_RS07725 ENOG4107ZFM Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) HZ306_RS07730 ENOG4105WS6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HZ306_RS07735 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) HZ306_RS07750 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HZ306_RS07755 ENOG4105ESV Glycosyl transferase, family 4 HZ306_RS07760 ENOG4105CAG UPF0210 protein HZ306_RS07765 ENOG4105VUC UPF0237 protein HZ306_RS07770 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 HZ306_RS07775 ENOG4108JYZ YitT family HZ306_RS07780 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) HZ306_RS07785 ENOG4105DRR Transcriptional regulator, GntR family HZ306_RS07795 ENOG4105D82 Glutamate dehydrogenase HZ306_RS07815 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) HZ306_RS07820 ENOG4105CGK Exodeoxyribonuclease III HZ306_RS07940 ENOG4106128 DNA-binding helix-turn-helix protein HZ306_RS07950 ENOG4106BHR ftsk SpoIIIE family protein HZ306_RS07960 ENOG4108RYM conjugative transposon protein HZ306_RS07990 ENOG4107RRN ABC transporter substrate-binding protein HZ306_RS08005 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HZ306_RS08010 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HZ306_RS08020 ENOG4105D5Q Arginine ornithine antiporter HZ306_RS08025 ENOG4105CH7 arginosuccinase HZ306_RS08030 ENOG4105CDH Citrulline--aspartate ligase HZ306_RS08040 ENOG4108JQC penicillin-binding protein 1A HZ306_RS08050 ENOG4105KRI phosphocarrier protein (HPr HZ306_RS08055 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HZ306_RS08060 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) HZ306_RS08065 ENOG4105DFD Na H antiporter HZ306_RS08070 ENOG4105DE4 1-phosphofructokinase HZ306_RS08075 ENOG4105DM4 PTS System HZ306_RS08095 ENOG4105C6T cysteine synthase HZ306_RS08100 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family HZ306_RS08105 ENOG4105D3R alkyl hydroperoxide reductase HZ306_RS08115 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HZ306_RS08120 ENOG4105C75 arginyL-tRNA synthetase HZ306_RS08145 ENOG4108K4B hydrolase HZ306_RS08165 ENOG4108J2R molybdopterin oxidoreductase HZ306_RS08170 ENOG4105DG4 malate L-lactate dehydrogenase HZ306_RS08185 ENOG4105C2C drug resistance transporter, Bcr CflA HZ306_RS08200 ENOG4108EKI Dehydrogenase HZ306_RS08205 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml HZ306_RS08215 ENOG4107RWI ethanolamine utilization protein eutJ HZ306_RS08220 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) HZ306_RS08225 ENOG4105KNY Microcompartments protein HZ306_RS08230 ENOG4105KNY Microcompartments protein HZ306_RS08235 ENOG4105EHR propanediol utilization protein pduB HZ306_RS08240 ENOG4105KNY Microcompartments protein HZ306_RS08245 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) HZ306_RS08250 ENOG4105KTW ethanolamine utilization protein HZ306_RS08255 ENOG4105M3W utilization protein HZ306_RS08260 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HZ306_RS08275 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit HZ306_RS08280 ENOG4108ZFT Dehydratase small subunit HZ306_RS08285 ENOG4105YCI dehydratase medium subunit HZ306_RS08290 ENOG4105DMB glycerol dehydratase HZ306_RS08295 ENOG4105EHR propanediol utilization protein pduB HZ306_RS08300 ENOG4107XVH Transcriptional regulator HZ306_RS08305 ENOG4105D01 (LipO)protein HZ306_RS08315 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) HZ306_RS08350 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HZ306_RS08355 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HZ306_RS08375 ENOG4108JPM phospho-2-dehydro-3-deoxyheptonate aldolase HZ306_RS08380 ENOG4105D49 3-dehydroquinate synthase HZ306_RS08385 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HZ306_RS08390 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HZ306_RS08395 ENOG4105CQC Prephenate dehydratase HZ306_RS08415 ENOG4105FF2 Type I DHQase HZ306_RS08420 ENOG4105C6X Major Facilitator HZ306_RS08425 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family HZ306_RS08430 ENOG4105C7N Xanthine uracil vitamin C permease HZ306_RS08455 ENOG4105C85 amino acid HZ306_RS08470 ENOG4105C34 Pseudouridine synthase HZ306_RS08490 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) HZ306_RS08495 ENOG4105C6E dna polymerase iii HZ306_RS08510 ENOG4105C34 Pseudouridine synthase HZ306_RS08525 ENOG4107X8C Efflux transporter RND family MFP subunit HZ306_RS08535 ENOG4105KMT branched-chain amino acid HZ306_RS08540 ENOG4108UMN azlc family HZ306_RS08545 ENOG4108I6A alcohol dehydrogenase HZ306_RS08550 ENOG4105D01 (LipO)protein HZ306_RS08565 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) HZ306_RS08570 ENOG4107QZF nitrite reductase NADPH large subunit HZ306_RS08580 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) HZ306_RS08585 ENOG4107QR9 Iron-sulfur cluster binding protein HZ306_RS08590 ENOG4107R5T Cysteine-rich domain HZ306_RS08610 ENOG4105EPD Oligopeptide transporter, Opt family HZ306_RS08620 ENOG4107RN3 metallophosphoesterase HZ306_RS08655 ENOG4105WMR Protein CrcB homolog HZ306_RS08670 ENOG4105CBD Diacylglycerol kinase HZ306_RS08675 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation HZ306_RS08680 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination HZ306_RS08700 ENOG4105FCD Major Facilitator HZ306_RS08780 ENOG4105CNA YD repeat protein HZ306_RS08830 ENOG4105CNA YD repeat protein HZ306_RS08900 ENOG4105DQ6 Transposase HZ306_RS08925 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HZ306_RS08930 ENOG4105CDU Replicative dna helicase HZ306_RS08940 ENOG4105BZR domain protein HZ306_RS08965 ENOG4105CN5 Metallo-Beta-Lactamase HZ306_RS08975 ENOG4105D7T ABC transporter HZ306_RS08980 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HZ306_RS08985 ENOG4107Z6I Thiamine biosynthesis protein HZ306_RS08990 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) HZ306_RS08995 ENOG4107T5V SNARE associated Golgi HZ306_RS09010 ENOG4105XTM Inherit from NOG: Mn2 dependent serine threonine protein kinase HZ306_RS09015 ENOG41086B8 CoB-CoM heterodisulfide reductase HZ306_RS09020 ENOG4105E33 succinate dehydrogenase HZ306_RS09025 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HZ306_RS09030 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HZ306_RS09035 ENOG41062D9 Histidine kinase HZ306_RS09040 ENOG4106BRA Membrane HZ306_RS09045 ENOG4106BRA Membrane HZ306_RS09055 ENOG4105KVH Transcriptional regulator HZ306_RS09060 ENOG4108RYK Nad-dependent epimerase dehydratase HZ306_RS09070 ENOG4108IJ2 phosphate acetyltransferase HZ306_RS09075 ENOG4105E4P ATPase (AAA HZ306_RS09090 ENOG4105BZ8 glutamate synthase HZ306_RS09095 ENOG4105C87 Aminotransferase class I and II HZ306_RS09125 ENOG4108W5N phosphatidylglycerophosphatase a HZ306_RS09135 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HZ306_RS09140 ENOG4105VUF Transcriptional regulator HZ306_RS09220 ENOG4108RS6 transposase HZ306_RS09230 ENOG4105F9F transposase HZ306_RS09250 ENOG4105CH6 catalase HZ306_RS09260 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HZ306_RS09270 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HZ306_RS09280 ENOG4105C83 adenylosuccinate lyase HZ306_RS09290 ENOG4105C6K Malic enzyme HZ306_RS09325 ENOG4105DJT lAO AO transport system ATPase HZ306_RS09330 ENOG4105D5P Methylmalonyl-coA mutase HZ306_RS09340 ENOG4105FR1 rard protein HZ306_RS09370 ENOG4105CQB FAD linked oxidase domain protein HZ306_RS09385 ENOG4105C0A alcohol dehydrogenase HZ306_RS09420 ENOG4105K56 Transcriptional regulator HZ306_RS09445 ENOG41080E8 Transcriptional regulator, Spx MgsR family HZ306_RS09450 ENOG4105VDM plasmid maintenance system antidote protein, xre family HZ306_RS09455 ENOG41080ET plasmid maintenance system killer protein HZ306_RS09465 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HZ306_RS09520 ENOG4107QN1 sodium solute HZ306_RS09530 ENOG4105CEE C4-dicarboxylate transporter HZ306_RS09535 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) HZ306_RS09560 ENOG4105DVF Cytosine-specific methyltransferase HZ306_RS09585 ENOG4107QHI -hydrogenase HZ306_RS09610 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HZ306_RS09615 ENOG4105E4P ATPase (AAA HZ306_RS09630 ENOG4105PW4 Sugar fermentation stimulation protein homolog HZ306_RS09645 ENOG4108IFG nitrite reductase, (NAD(P)H) HZ306_RS09680 ENOG4106D5S Corrinoid adenosyltransferase BtuR CobO CobP HZ306_RS09685 ENOG4105E4C Lytic transglycosylase catalytic HZ306_RS09695 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) HZ306_RS09700 ENOG4105FA0 parb-like partition protein HZ306_RS09705 ENOG4107QJE Chromosome Partitioning Protein HZ306_RS09715 ENOG4105C3R Methionine synthase HZ306_RS09725 ENOG4108RS6 transposase HZ306_RS09730 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) HZ306_RS09735 ENOG4105XMH SpoVT AbrB domain protein HZ306_RS09740 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A HZ306_RS09745 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) HZ306_RS09750 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) HZ306_RS09755 ENOG4108Z7S Single-stranded nucleic acid binding R3H domain-containing protein HZ306_RS09760 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HZ306_RS09765 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) HZ306_RS09770 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) HZ306_RS09775 ENOG4105VG0 50S ribosomal protein l34