locus-tag	class	description
HZ306_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HZ306_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HZ306_RS00035	COG0187	DNA topoisomerase II activity
HZ306_RS00040	COG0833	amino acid
HZ306_RS00050	COG1733	regulation of RNA biosynthetic process
HZ306_RS00070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HZ306_RS00075	COG1253	flavin adenine dinucleotide binding
HZ306_RS00105	COG0438	transferase activity, transferring glycosyl groups
HZ306_RS00125	COG3594	Acyltransferase
HZ306_RS00130	COG0562	UDP-galactopyranose mutase
HZ306_RS00145	COG0438	transferase activity, transferring glycosyl groups
HZ306_RS00155	COG2244	polysaccharide biosynthetic process
HZ306_RS00210	COG4797	methyltransferase
HZ306_RS00210	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HZ306_RS00265	COG0501	Belongs to the peptidase M48B family
HZ306_RS00270	COG0811	peptide transport
HZ306_RS00275	COG0848	biopolymer transport protein
HZ306_RS00295	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HZ306_RS00300	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HZ306_RS00305	COG1120	ATPase activity
HZ306_RS00330	COG4771	TonB-dependent receptor
HZ306_RS00335	COG0436	Aminotransferase
HZ306_RS00340	COG0640	Transcriptional regulator
HZ306_RS00350	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HZ306_RS00365	COG4221	oxidoreductase activity
HZ306_RS00390	COG0747	negative chemotaxis
HZ306_RS00395	COG0444	Belongs to the ABC transporter superfamily
HZ306_RS00400	COG4608	Belongs to the ABC transporter superfamily
HZ306_RS00465	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HZ306_RS00470	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HZ306_RS00475	COG0066	3-isopropylmalate dehydratase activity
HZ306_RS00480	COG0473	3-isopropylmalate dehydrogenase activity
HZ306_RS00510	COG1196	nuclear chromosome segregation
HZ306_RS00535	COG0497	DNA recombination
HZ306_RS00545	COG1879	ABC-type sugar transport system periplasmic component
HZ306_RS00550	COG1172	Belongs to the binding-protein-dependent transport system permease family
HZ306_RS00555	COG1129	ABC transporter
HZ306_RS00560	COG1869	D-ribose catabolic process
HZ306_RS00565	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HZ306_RS00585	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HZ306_RS00600	COG1122	ATPase activity
HZ306_RS00605	COG1122	ATPase activity
HZ306_RS00620	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HZ306_RS00630	COG1966	Carbon starvation protein
HZ306_RS00660	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HZ306_RS00670	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HZ306_RS00675	COG1045	serine acetyltransferase
HZ306_RS00690	COG1914	H( )-stimulated, divalent metal cation uptake system
HZ306_RS00700	COG3022	response to hydroperoxide
HZ306_RS00705	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HZ306_RS00715	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HZ306_RS00720	COG2731	YhcH YjgK YiaL family protein
HZ306_RS00725	COG0697	spore germination
HZ306_RS00755	COG3069	C4-dicarboxylate transmembrane transporter activity
HZ306_RS00775	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HZ306_RS00775	COG0512	Glutamine amidotransferase of anthranilate synthase
HZ306_RS00780	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HZ306_RS00785	COG0134	indole-3-glycerol-phosphate synthase activity
HZ306_RS00790	COG0133	tryptophan synthase activity
HZ306_RS00795	COG0159	tryptophan synthase activity
HZ306_RS00825	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HZ306_RS00850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HZ306_RS00865	COG0561	phosphatase activity
HZ306_RS00875	COG0519	Catalyzes the synthesis of GMP from XMP
HZ306_RS00875	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HZ306_RS00930	COG0456	acetyltransferase
HZ306_RS00935	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HZ306_RS00940	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HZ306_RS00945	COG1121	(ABC) transporter
HZ306_RS00950	COG0803	Belongs to the bacterial solute-binding protein 9 family
HZ306_RS00980	COG1151	hydroxylamine reductase activity
HZ306_RS00985	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HZ306_RS01000	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HZ306_RS01005	COG0420	3'-5' exonuclease activity
HZ306_RS01010	COG4717	serine-type aminopeptidase activity
HZ306_RS01015	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HZ306_RS01035	COG2223	nitrite transmembrane transporter activity
HZ306_RS01040	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HZ306_RS01045	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HZ306_RS01050	COG1140	nitrate reductase beta subunit
HZ306_RS01055	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HZ306_RS01060	COG2181	nitrate reductase activity
HZ306_RS01070	COG3206	protein involved in exopolysaccharide biosynthesis
HZ306_RS01080	COG2814	Major facilitator Superfamily
HZ306_RS01085	COG0583	DNA-binding transcription factor activity
HZ306_RS01095	COG2855	membrane
HZ306_RS01100	COG0288	reversible hydration of carbon dioxide
HZ306_RS01105	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HZ306_RS01110	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HZ306_RS01115	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HZ306_RS01125	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HZ306_RS01130	COG1121	(ABC) transporter
HZ306_RS01135	COG0803	Belongs to the bacterial solute-binding protein 9 family
HZ306_RS01140	COG2184	nucleotidyltransferase activity
HZ306_RS01190	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HZ306_RS01195	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HZ306_RS01200	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HZ306_RS01205	COG1882	Formate acetyltransferase
HZ306_RS01225	COG2011	ABC-type metal ion transport system permease component
HZ306_RS01235	COG1132	(ABC) transporter
HZ306_RS01245	COG0471	metal ion transport
HZ306_RS01260	COG0626	cystathionine gamma-synthase activity
HZ306_RS01265	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HZ306_RS01270	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HZ306_RS01275	COG2873	o-acetylhomoserine
HZ306_RS01295	COG0701	Predicted permease
HZ306_RS01300	COG0523	cobalamin synthesis protein
HZ306_RS01305	COG2195	Cleaves the N-terminal amino acid of tripeptides
HZ306_RS01310	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HZ306_RS01320	COG0252	asparaginase activity
HZ306_RS01330	COG0668	transmembrane transport
HZ306_RS01335	COG1686	Belongs to the peptidase S11 family
HZ306_RS01345	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HZ306_RS01355	COG2080	2 iron, 2 sulfur cluster binding
HZ306_RS01360	COG2080	2 iron, 2 sulfur cluster binding
HZ306_RS01360	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HZ306_RS01380	COG3608	succinylglutamate desuccinylase aspartoacylase
HZ306_RS01380	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HZ306_RS01390	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HZ306_RS01395	COG4856	YbbR-like protein
HZ306_RS01400	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HZ306_RS01405	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HZ306_RS01430	COG4735	regulation of single-species biofilm formation
HZ306_RS01435	COG2020	methyltransferase activity
HZ306_RS01445	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HZ306_RS01450	COG0180	Tryptophanyl-tRNA synthetase
HZ306_RS01460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HZ306_RS01465	COG0765	amino acid transport
HZ306_RS01470	COG1126	abc transporter atp-binding protein
HZ306_RS01480	COG0589	response to stress
HZ306_RS01485	COG0640	Transcriptional regulator
HZ306_RS01495	COG0725	ABC transporter, periplasmic molybdate-binding protein
HZ306_RS01500	COG4149	molybdate abc transporter
HZ306_RS01505	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HZ306_RS01530	COG1592	Rubrerythrin
HZ306_RS01540	COG0709	Synthesizes selenophosphate from selenide and ATP
HZ306_RS01555	COG0778	Nitroreductase
HZ306_RS01560	COG2261	transglycosylase associated protein
HZ306_RS01570	COG0012	GTP binding
HZ306_RS01580	COG0436	Aminotransferase
HZ306_RS01595	COG2814	Major facilitator Superfamily
HZ306_RS01600	COG0360	Binds together with S18 to 16S ribosomal RNA
HZ306_RS01605	COG0629	single-stranded DNA binding
HZ306_RS01610	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HZ306_RS01625	COG1433	Dinitrogenase iron-molybdenum cofactor
HZ306_RS01625	COG0535	radical SAM domain protein
HZ306_RS01630	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HZ306_RS01650	COG0789	Transcriptional regulator
HZ306_RS01655	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HZ306_RS01670	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HZ306_RS01675	COG0772	Belongs to the SEDS family
HZ306_RS01720	COG2195	Cleaves the N-terminal amino acid of tripeptides
HZ306_RS01735	COG2040	homocysteine
HZ306_RS01745	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HZ306_RS01745	COG0426	domain, Protein
HZ306_RS01750	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HZ306_RS01755	COG0583	DNA-binding transcription factor activity
HZ306_RS01760	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HZ306_RS01775	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HZ306_RS01780	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HZ306_RS01785	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HZ306_RS01790	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HZ306_RS01795	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HZ306_RS01805	COG0151	Belongs to the GarS family
HZ306_RS01810	COG1169	isochorismate synthase
HZ306_RS01815	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HZ306_RS01820	COG0596	Alpha beta hydrolase
HZ306_RS01825	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HZ306_RS01830	COG0318	PFAM AMP-dependent synthetase and ligase
HZ306_RS01910	COG1649	PFAM Uncharacterised BCR, COG1649
HZ306_RS01910	COG0726	polysaccharide deacetylase
HZ306_RS01915	COG4632	Exopolysaccharide biosynthesis protein
HZ306_RS01915	COG5434	Belongs to the glycosyl hydrolase 28 family
HZ306_RS01925	COG0859	PFAM glycosyl transferase family 9
HZ306_RS01950	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HZ306_RS01970	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HZ306_RS01975	COG0284	orotidine-5'-phosphate decarboxylase activity
HZ306_RS02000	COG1464	Belongs to the NlpA lipoprotein family
HZ306_RS02005	COG1575	Belongs to the MenA family. Type 1 subfamily
HZ306_RS02020	COG0251	oxidation-reduction process
HZ306_RS02025	COG3681	Belongs to the UPF0597 family
HZ306_RS02030	COG2223	nitrite transmembrane transporter activity
HZ306_RS02040	COG0590	tRNA wobble adenosine to inosine editing
HZ306_RS02065	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HZ306_RS02070	COG2011	ABC-type metal ion transport system permease component
HZ306_RS02075	COG4496	protein, YerC YecD
HZ306_RS02080	COG0730	response to heat
HZ306_RS02085	COG1028	Short-chain dehydrogenase reductase Sdr
HZ306_RS02095	COG3339	Conserved Protein
HZ306_RS02100	COG0824	Thioesterase
HZ306_RS02105	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HZ306_RS02120	COG0145	ligase activity
HZ306_RS02130	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HZ306_RS02150	COG0281	malic enzyme
HZ306_RS02185	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HZ306_RS02190	COG1914	H( )-stimulated, divalent metal cation uptake system
HZ306_RS02195	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HZ306_RS02200	COG1984	allophanate hydrolase subunit 2
HZ306_RS02215	COG0534	Mate efflux family protein
HZ306_RS02220	COG2885	chlorophyll binding
HZ306_RS02225	COG0628	permease
HZ306_RS02240	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HZ306_RS02245	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HZ306_RS02250	COG2226	methyltransferase
HZ306_RS02310	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HZ306_RS02315	COG2244	polysaccharide biosynthetic process
HZ306_RS02320	COG3956	TIGRFAM MazG family protein
HZ306_RS02325	COG0776	regulation of translation
HZ306_RS02330	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HZ306_RS02340	COG0488	(ABC) transporter
HZ306_RS02355	COG0306	phosphate transporter
HZ306_RS02370	COG1120	ATPase activity
HZ306_RS02400	COG0662	Cupin 2, conserved barrel domain protein
HZ306_RS02400	COG2207	Transcriptional regulator
HZ306_RS02405	COG4771	TonB-dependent receptor
HZ306_RS02410	COG0811	peptide transport
HZ306_RS02415	COG0848	biopolymer transport protein
HZ306_RS02435	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HZ306_RS02440	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HZ306_RS02445	COG0569	domain protein
HZ306_RS02465	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HZ306_RS02470	COG0315	cyclic pyranopterin monophosphate synthase activity
HZ306_RS02475	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HZ306_RS02480	COG3679	Belongs to the UPF0342 family
HZ306_RS02490	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HZ306_RS02545	COG0028	Belongs to the TPP enzyme family
HZ306_RS02550	COG0440	acetolactate synthase activity
HZ306_RS02555	COG0288	reversible hydration of carbon dioxide
HZ306_RS02570	COG1473	amidohydrolase
HZ306_RS02580	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HZ306_RS02585	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HZ306_RS02590	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HZ306_RS02600	COG1473	amidohydrolase
HZ306_RS02605	COG3069	C4-dicarboxylate transmembrane transporter activity
HZ306_RS02615	COG2223	nitrite transmembrane transporter activity
HZ306_RS02625	COG3859	Proton-coupled thiamine transporter YuaJ
HZ306_RS02645	COG0542	response to heat
HZ306_RS02650	COG2207	Transcriptional regulator
HZ306_RS02660	COG2207	Transcriptional regulator
HZ306_RS02660	COG1917	Cupin 2, conserved barrel domain protein
HZ306_RS02665	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HZ306_RS02670	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HZ306_RS02675	COG0471	metal ion transport
HZ306_RS02690	COG2233	PERMEase
HZ306_RS02700	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HZ306_RS02720	COG2837	iron assimilation
HZ306_RS02725	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HZ306_RS02735	COG3593	DNA synthesis involved in DNA repair
HZ306_RS02740	COG1970	mechanosensitive ion channel activity
HZ306_RS02780	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HZ306_RS02785	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HZ306_RS02790	COG0549	Belongs to the carbamate kinase family
HZ306_RS02795	COG0402	S-adenosylhomocysteine deaminase activity
HZ306_RS02800	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HZ306_RS02800	COG0493	'glutamate synthase
HZ306_RS02815	COG2233	PERMEase
HZ306_RS02820	COG1850	ribulose-bisphosphate carboxylase activity
HZ306_RS02825	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HZ306_RS02830	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HZ306_RS02835	COG0517	IMP dehydrogenase activity
HZ306_RS02835	COG0516	GMP reductase activity
HZ306_RS02840	COG0544	peptidyl-prolyl cis-trans isomerase activity
HZ306_RS02845	COG0740	serine-type endopeptidase activity
HZ306_RS02850	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HZ306_RS02855	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HZ306_RS02860	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HZ306_RS02870	COG0805	protein transport
HZ306_RS02875	COG0525	valine-tRNA ligase activity
HZ306_RS02880	COG0285	dihydrofolate synthase activity
HZ306_RS02890	COG0427	acetyl-CoA hydrolase
HZ306_RS02895	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HZ306_RS02895	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HZ306_RS02900	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HZ306_RS02900	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HZ306_RS02910	COG0346	lactoylglutathione lyase activity
HZ306_RS02915	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HZ306_RS02930	COG0511	ligase activity, forming carbon-carbon bonds
HZ306_RS02935	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HZ306_RS02945	COG0471	metal ion transport
HZ306_RS02945	COG0490	domain, Protein
HZ306_RS02950	COG0471	metal ion transport
HZ306_RS02950	COG0490	domain, Protein
HZ306_RS02965	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HZ306_RS02970	COG0564	pseudouridine synthase activity
HZ306_RS02975	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HZ306_RS02980	COG1323	Belongs to the UPF0348 family
HZ306_RS03000	COG0424	maF-like protein
HZ306_RS03005	COG2003	Belongs to the UPF0758 family
HZ306_RS03010	COG1077	Cell shape determining protein MreB Mrl
HZ306_RS03025	COG0768	penicillin binding
HZ306_RS03030	COG2894	cell division
HZ306_RS03035	COG0772	Belongs to the SEDS family
HZ306_RS03050	COG1530	ribonuclease E activity
HZ306_RS03055	COG1971	Probably functions as a manganese efflux pump
HZ306_RS03060	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HZ306_RS03070	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HZ306_RS03075	COG4619	ABC transporter
HZ306_RS03080	COG0390	transport system, permease component
HZ306_RS03085	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HZ306_RS03090	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HZ306_RS03090	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HZ306_RS03095	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HZ306_RS03100	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HZ306_RS03105	COG0735	belongs to the Fur family
HZ306_RS03110	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HZ306_RS03120	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HZ306_RS03160	COG1058	Belongs to the CinA family
HZ306_RS03160	COG1546	Belongs to the CinA family
HZ306_RS03165	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HZ306_RS03170	COG2137	regulation of response to DNA damage stimulus
HZ306_RS03175	COG1418	mRNA catabolic process
HZ306_RS03180	COG0358	DNA primase activity
HZ306_RS03185	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HZ306_RS03195	COG0602	queuosine metabolic process
HZ306_RS03215	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HZ306_RS03225	COG3118	belongs to the thioredoxin family
HZ306_RS03245	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HZ306_RS03255	COG0463	Glycosyl transferase, family 2
HZ306_RS03260	COG0791	NLP P60 protein
HZ306_RS03260	COG1388	LysM domain
HZ306_RS03265	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HZ306_RS03270	COG4472	Bacterial protein of unknown function (DUF965)
HZ306_RS03275	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HZ306_RS03280	COG3906	Belongs to the UPF0473 family
HZ306_RS03290	COG4122	O-methyltransferase activity
HZ306_RS03310	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HZ306_RS03315	COG2814	Major facilitator Superfamily
HZ306_RS03320	COG0471	metal ion transport
HZ306_RS03325	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HZ306_RS03330	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HZ306_RS03335	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HZ306_RS03370	COG5290	Psort location Cytoplasmic, score
HZ306_RS03385	COG1401	restriction endodeoxyribonuclease activity
HZ306_RS03420	COG0546	phosphoglycolate phosphatase activity
HZ306_RS03435	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HZ306_RS03450	COG2244	polysaccharide biosynthetic process
HZ306_RS03455	COG0191	fructose-bisphosphate aldolase activity
HZ306_RS03460	COG0564	pseudouridine synthase activity
HZ306_RS03475	COG1666	GTP binding
HZ306_RS03480	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
HZ306_RS03520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HZ306_RS03525	COG1120	ATPase activity
HZ306_RS03545	COG4822	anaerobic cobalamin biosynthetic process
HZ306_RS03565	COG2033	superoxide reductase activity
HZ306_RS03585	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HZ306_RS03595	COG3118	belongs to the thioredoxin family
HZ306_RS03605	COG2001	Belongs to the MraZ family
HZ306_RS03610	COG0275	rRNA processing
HZ306_RS03620	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HZ306_RS03625	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HZ306_RS03630	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HZ306_RS03640	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HZ306_RS03645	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HZ306_RS03650	COG1181	Belongs to the D-alanine--D-alanine ligase family
HZ306_RS03665	COG3856	small basic protein
HZ306_RS03670	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HZ306_RS03690	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HZ306_RS03705	COG0254	rRNA binding
HZ306_RS03710	COG3872	metal-dependent enzyme
HZ306_RS03720	COG2890	protein-(glutamine-N5) methyltransferase activity
HZ306_RS03725	COG0009	L-threonylcarbamoyladenylate synthase
HZ306_RS03730	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HZ306_RS03735	COG0698	ribose 5-phosphate isomerase
HZ306_RS03740	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HZ306_RS03760	COG0126	phosphoglycerate kinase activity
HZ306_RS03765	COG0149	triose-phosphate isomerase activity
HZ306_RS03770	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HZ306_RS03775	COG0148	phosphopyruvate hydratase activity
HZ306_RS03780	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HZ306_RS03790	COG1459	type II secretion system
HZ306_RS03795	COG4968	Prepilin-type N-terminal cleavage methylation domain
HZ306_RS03840	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HZ306_RS03850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HZ306_RS03855	COG1136	(ABC) transporter
HZ306_RS03860	COG1136	(ABC) transporter
HZ306_RS03860	COG0577	efflux transmembrane transporter activity
HZ306_RS03870	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HZ306_RS03875	COG0072	phenylalanine-tRNA ligase activity
HZ306_RS03875	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HZ306_RS03880	COG0826	peptidase U32
HZ306_RS03885	COG1193	negative regulation of DNA recombination
HZ306_RS03890	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HZ306_RS03895	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HZ306_RS03905	COG0574	Belongs to the PEP-utilizing enzyme family
HZ306_RS03905	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HZ306_RS03910	COG0517	IMP dehydrogenase activity
HZ306_RS03915	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HZ306_RS03920	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HZ306_RS03925	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HZ306_RS03930	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HZ306_RS03935	COG1942	4-Oxalocrotonate Tautomerase
HZ306_RS03940	COG0516	GMP reductase activity
HZ306_RS03940	COG0517	IMP dehydrogenase activity
HZ306_RS03945	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HZ306_RS03950	COG0688	phosphatidylethanolamine metabolic process
HZ306_RS03960	COG1215	transferase activity, transferring glycosyl groups
HZ306_RS03980	COG0736	holo-[acyl-carrier-protein] synthase activity
HZ306_RS03985	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HZ306_RS03985	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HZ306_RS03990	COG0658	competence protein
HZ306_RS03990	COG2333	competence protein COMEC
HZ306_RS03995	COG0860	N-Acetylmuramoyl-L-alanine amidase
HZ306_RS04005	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HZ306_RS04010	COG0802	atpase or kinase
HZ306_RS04015	COG1214	PFAM Peptidase M22, glycoprotease
HZ306_RS04040	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HZ306_RS04045	COG0459	protein refolding
HZ306_RS04060	COG0396	ATPase activity
HZ306_RS04075	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HZ306_RS04080	COG0822	iron-sulfur transferase activity
HZ306_RS04100	COG3880	PFAM UvrB UvrC protein
HZ306_RS04105	COG3869	Catalyzes the specific phosphorylation of arginine residues in
HZ306_RS04110	COG0542	response to heat
HZ306_RS04115	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HZ306_RS04120	COG4956	integral membrane protein (PIN domain superfamily)
HZ306_RS04125	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HZ306_RS04125	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HZ306_RS04130	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HZ306_RS04135	COG0385	Bile acid
HZ306_RS04140	COG0215	cysteine-tRNA ligase activity
HZ306_RS04145	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HZ306_RS04150	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HZ306_RS04165	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HZ306_RS04170	COG0557	exoribonuclease II activity
HZ306_RS04175	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HZ306_RS04185	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
HZ306_RS04210	COG1227	inorganic diphosphatase activity
HZ306_RS04215	COG0210	DNA helicase
HZ306_RS04220	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HZ306_RS04240	COG0154	amidase activity
HZ306_RS04245	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HZ306_RS04260	COG1242	4 iron, 4 sulfur cluster binding
HZ306_RS04265	COG1702	phosphate starvation-inducible protein PhoH
HZ306_RS04275	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HZ306_RS04280	COG1253	flavin adenine dinucleotide binding
HZ306_RS04315	COG0752	glycyl-tRNA synthetase alpha subunit
HZ306_RS04320	COG0751	glycine-tRNA ligase activity
HZ306_RS04330	COG0335	large ribosomal subunit rRNA binding
HZ306_RS04340	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HZ306_RS04345	COG0792	nuclease activity
HZ306_RS04355	COG0758	DNA mediated transformation
HZ306_RS04360	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HZ306_RS04365	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HZ306_RS04370	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HZ306_RS04375	COG1388	LysM domain
HZ306_RS04375	COG3858	chitin binding
HZ306_RS04380	COG0495	leucyl-tRNA aminoacylation
HZ306_RS04395	COG1555	photosystem II stabilization
HZ306_RS04425	COG0028	Belongs to the TPP enzyme family
HZ306_RS04430	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HZ306_RS04430	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HZ306_RS04440	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HZ306_RS04440	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HZ306_RS04450	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HZ306_RS04455	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HZ306_RS04460	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HZ306_RS04465	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HZ306_RS04470	COG0402	S-adenosylhomocysteine deaminase activity
HZ306_RS04480	COG2226	methyltransferase
HZ306_RS04505	COG0671	phosphoesterase, PA-phosphatase related
HZ306_RS04510	COG2720	vancomycin resistance protein
HZ306_RS04525	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HZ306_RS04530	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HZ306_RS04535	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HZ306_RS04540	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HZ306_RS04555	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HZ306_RS04560	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HZ306_RS04575	COG1722	exodeoxyribonuclease VII activity
HZ306_RS04585	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HZ306_RS04590	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HZ306_RS04605	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HZ306_RS04610	COG0006	proline dipeptidase activity
HZ306_RS04615	COG1187	pseudouridine synthase activity
HZ306_RS04620	COG0406	alpha-ribazole phosphatase activity
HZ306_RS04635	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HZ306_RS04645	COG1492	cobalamin metabolic process
HZ306_RS04665	COG0105	UTP biosynthetic process
HZ306_RS04675	COG0083	homoserine kinase activity
HZ306_RS04680	COG0460	homoserine dehydrogenase
HZ306_RS04685	COG4492	Belongs to the UPF0735 family
HZ306_RS04695	COG3394	polysaccharide catabolic process
HZ306_RS04700	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HZ306_RS04705	COG1132	(ABC) transporter
HZ306_RS04710	COG1132	(ABC) transporter
HZ306_RS04715	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HZ306_RS04725	COG0174	glutamine synthetase
HZ306_RS04730	COG1610	YqeY-like protein
HZ306_RS04735	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HZ306_RS04740	COG0537	adenosine 5'-monophosphoramidase activity
HZ306_RS04745	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HZ306_RS04750	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HZ306_RS04755	COG2264	protein methyltransferase activity
HZ306_RS04760	COG0484	heat shock protein binding
HZ306_RS04765	COG0443	Heat shock 70 kDa protein
HZ306_RS04770	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HZ306_RS04775	COG1420	regulation of RNA biosynthetic process
HZ306_RS04785	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HZ306_RS04790	COG0481	GTPase activity
HZ306_RS04795	COG0482	sulfurtransferase activity
HZ306_RS04800	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HZ306_RS04805	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HZ306_RS04810	COG2521	methyltransferase
HZ306_RS04810	COG2136	Putative SAM-dependent methyltransferase
HZ306_RS04815	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HZ306_RS04820	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HZ306_RS04825	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HZ306_RS04840	COG0442	prolyl-tRNA aminoacylation
HZ306_RS04845	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HZ306_RS04850	COG0750	zinc metalloprotease
HZ306_RS04855	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HZ306_RS04860	COG4589	Belongs to the CDS family
HZ306_RS04875	COG0233	cytoplasmic translational termination
HZ306_RS04880	COG0528	UMP kinase activity
HZ306_RS04885	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HZ306_RS04890	COG0052	Belongs to the universal ribosomal protein uS2 family
HZ306_RS04895	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HZ306_RS04900	COG1162	GTPase activity
HZ306_RS04905	COG2815	serine threonine protein kinase
HZ306_RS04905	COG0515	serine threonine protein kinase
HZ306_RS04910	COG0631	protein serine/threonine phosphatase activity
HZ306_RS04915	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HZ306_RS04920	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HZ306_RS04920	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HZ306_RS04930	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HZ306_RS04935	COG0242	peptide deformylase activity
HZ306_RS04940	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HZ306_RS04945	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HZ306_RS04950	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HZ306_RS04955	COG1758	RNA polymerase activity
HZ306_RS04960	COG0194	GDP metabolic process
HZ306_RS04970	COG1561	YicC-like family, N-terminal region
HZ306_RS04975	COG1293	RNA-binding protein homologous to eukaryotic snRNP
HZ306_RS04985	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HZ306_RS04990	COG0742	ribosomal rna small subunit methyltransferase
HZ306_RS04995	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HZ306_RS05000	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HZ306_RS05005	COG1160	GTP binding
HZ306_RS05010	COG0539	negative regulation of cytoplasmic translation
HZ306_RS05010	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HZ306_RS05020	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HZ306_RS05025	COG2081	HI0933 family
HZ306_RS05030	COG1187	pseudouridine synthase activity
HZ306_RS05035	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HZ306_RS05040	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HZ306_RS05050	COG1683	Conserved Protein
HZ306_RS05080	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HZ306_RS05085	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HZ306_RS05090	COG0569	domain protein
HZ306_RS05095	COG2996	Protein conserved in bacteria
HZ306_RS05100	COG0799	negative regulation of ribosome biogenesis
HZ306_RS05105	COG1316	TRANSCRIPTIONal
HZ306_RS05110	COG1713	HD superfamily hydrolase involved in NAD metabolism
HZ306_RS05115	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HZ306_RS05120	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HZ306_RS05125	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HZ306_RS05135	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HZ306_RS05140	COG0793	Belongs to the peptidase S41A family
HZ306_RS05145	COG0739	heme binding
HZ306_RS05150	COG2177	Part of the ABC transporter FtsEX involved in
HZ306_RS05155	COG2884	Cell division ATP-binding protein ftsE
HZ306_RS05160	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HZ306_RS05165	COG3959	Transketolase, thiamine diphosphate binding domain
HZ306_RS05190	COG0653	protein targeting
HZ306_RS05200	COG1278	Cold shock
HZ306_RS05210	COG0765	amino acid transport
HZ306_RS05215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HZ306_RS05225	COG1040	competence protein
HZ306_RS05230	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HZ306_RS05240	COG0196	riboflavin kinase activity
HZ306_RS05255	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HZ306_RS05260	COG3064	Membrane
HZ306_RS05260	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HZ306_RS05260	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HZ306_RS05260	COG3064	Membrane
HZ306_RS05265	COG1358	cellular component organization or biogenesis
HZ306_RS05275	COG0195	Participates in both transcription termination and antitermination
HZ306_RS05280	COG0779	Required for maturation of 30S ribosomal subunits
HZ306_RS05290	COG0741	lytic transglycosylase activity
HZ306_RS05295	COG0237	dephospho-CoA kinase activity
HZ306_RS05300	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HZ306_RS05300	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HZ306_RS05305	COG0268	Binds directly to 16S ribosomal RNA
HZ306_RS05320	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HZ306_RS05340	COG0756	dUTP diphosphatase activity
HZ306_RS05345	COG1185	polyribonucleotide nucleotidyltransferase activity
HZ306_RS05355	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HZ306_RS05360	COG4120	Belongs to the binding-protein-dependent transport system permease family
HZ306_RS05380	COG1362	aminopeptidase activity
HZ306_RS05385	COG2176	DNA-directed DNA polymerase activity
HZ306_RS05395	COG0859	PFAM glycosyl transferase family 9
HZ306_RS05400	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HZ306_RS05405	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HZ306_RS05410	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HZ306_RS05410	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HZ306_RS05415	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HZ306_RS05425	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HZ306_RS05430	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HZ306_RS05435	COG1362	aminopeptidase activity
HZ306_RS05440	COG0471	metal ion transport
HZ306_RS05450	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HZ306_RS05465	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HZ306_RS05475	COG0179	Fumarylacetoacetate (FAA) hydrolase
HZ306_RS05560	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HZ306_RS05565	COG0861	Integral membrane protein TerC family
HZ306_RS05570	COG0861	Integral membrane protein TerC family
HZ306_RS05575	COG0534	Mate efflux family protein
HZ306_RS05585	COG0322	excinuclease ABC activity
HZ306_RS05590	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HZ306_RS05595	COG0556	nucleotide-excision repair
HZ306_RS05605	COG0552	protein localization to endoplasmic reticulum
HZ306_RS05610	COG1196	nuclear chromosome segregation
HZ306_RS05615	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HZ306_RS05620	COG0571	ribonuclease III activity
HZ306_RS05625	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HZ306_RS05630	COG2070	2-Nitropropane dioxygenase
HZ306_RS05635	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HZ306_RS05640	COG1028	Short-chain dehydrogenase reductase Sdr
HZ306_RS05645	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HZ306_RS05655	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HZ306_RS05660	COG0416	fatty acid biosynthetic process
HZ306_RS05670	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HZ306_RS05680	COG1773	rubredoxin
HZ306_RS05700	COG0602	queuosine metabolic process
HZ306_RS05765	COG3475	LICD family
HZ306_RS05770	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HZ306_RS05775	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HZ306_RS05780	COG3206	protein involved in exopolysaccharide biosynthesis
HZ306_RS05780	COG0489	protein tyrosine kinase activity
HZ306_RS05825	COG0488	(ABC) transporter
HZ306_RS05830	COG1450	Type ii and iii secretion system protein
HZ306_RS05845	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HZ306_RS05850	COG0166	Belongs to the GPI family
HZ306_RS05860	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HZ306_RS05870	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HZ306_RS05880	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HZ306_RS05885	COG0183	Belongs to the thiolase family
HZ306_RS05890	COG1268	BioY protein
HZ306_RS05925	COG0409	Hydrogenase expression formation protein
HZ306_RS05930	COG0298	carbon dioxide binding
HZ306_RS05935	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HZ306_RS05940	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HZ306_RS05980	COG1918	ferrous iron import across plasma membrane
HZ306_RS05980	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HZ306_RS05995	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HZ306_RS06000	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HZ306_RS06005	COG0786	glutamate:sodium symporter activity
HZ306_RS06010	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HZ306_RS06015	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HZ306_RS06020	COG0583	DNA-binding transcription factor activity
HZ306_RS06025	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HZ306_RS06030	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HZ306_RS06030	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HZ306_RS06035	COG1388	LysM domain
HZ306_RS06035	COG3584	3D domain protein
HZ306_RS06040	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HZ306_RS06055	COG0084	hydrolase, TatD family'
HZ306_RS06060	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HZ306_RS06060	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HZ306_RS06065	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HZ306_RS06075	COG1774	PSP1 C-terminal conserved region
HZ306_RS06080	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HZ306_RS06085	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HZ306_RS06090	COG1982	Orn Lys Arg decarboxylase major
HZ306_RS06095	COG0193	aminoacyl-tRNA hydrolase activity
HZ306_RS06105	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HZ306_RS06110	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HZ306_RS06115	COG1388	LysM domain
HZ306_RS06115	COG3584	3D domain protein
HZ306_RS06120	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HZ306_RS06125	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HZ306_RS06140	COG3585	molybdate ion transport
HZ306_RS06165	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HZ306_RS06170	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HZ306_RS06180	COG1862	Preprotein translocase
HZ306_RS06185	COG0343	queuine tRNA-ribosyltransferase activity
HZ306_RS06195	COG2385	sporulation resulting in formation of a cellular spore
HZ306_RS06195	COG2247	cell wall binding repeat
HZ306_RS06200	COG2255	four-way junction helicase activity
HZ306_RS06205	COG0632	four-way junction helicase activity
HZ306_RS06210	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HZ306_RS06220	COG4752	Belongs to the RNA methyltransferase TrmD family
HZ306_RS06245	COG0702	epimerase
HZ306_RS06250	COG0336	Belongs to the RNA methyltransferase TrmD family
HZ306_RS06255	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HZ306_RS06275	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HZ306_RS06280	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HZ306_RS06285	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HZ306_RS06295	COG2217	Heavy metal translocating P-type atpase
HZ306_RS06300	COG1739	Uncharacterized protein family UPF0029
HZ306_RS06310	COG0583	DNA-binding transcription factor activity
HZ306_RS06315	COG0167	dihydroorotate dehydrogenase activity
HZ306_RS06320	COG0543	2 iron, 2 sulfur cluster binding
HZ306_RS06335	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HZ306_RS06340	COG0540	Belongs to the ATCase OTCase family
HZ306_RS06350	COG1481	regulation of sporulation
HZ306_RS06355	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HZ306_RS06360	COG1660	Displays ATPase and GTPase activities
HZ306_RS06365	COG0561	phosphatase activity
HZ306_RS06370	COG0497	DNA recombination
HZ306_RS06375	COG0497	DNA recombination
HZ306_RS06385	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HZ306_RS06395	COG4372	Transposase
HZ306_RS06405	COG1137	ATPase activity
HZ306_RS06410	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HZ306_RS06425	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HZ306_RS06435	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HZ306_RS06440	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HZ306_RS06445	COG1663	tetraacyldisaccharide 4'-kinase activity
HZ306_RS06450	COG1519	Transferase
HZ306_RS06455	COG1132	(ABC) transporter
HZ306_RS06460	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HZ306_RS06470	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HZ306_RS06475	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HZ306_RS06480	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HZ306_RS06485	COG1560	Kdo2-lipid A biosynthetic process
HZ306_RS06490	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HZ306_RS06530	COG1127	ABC transporter
HZ306_RS06535	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HZ306_RS06560	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HZ306_RS06565	COG1494	fructose-1,6-bisphosphatase
HZ306_RS06570	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HZ306_RS06585	COG0402	S-adenosylhomocysteine deaminase activity
HZ306_RS06590	COG1982	Orn Lys Arg decarboxylase major
HZ306_RS06595	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HZ306_RS06600	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HZ306_RS06605	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HZ306_RS06610	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HZ306_RS06625	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HZ306_RS06635	COG0037	tRNA processing
HZ306_RS06645	COG1098	S1 RNA binding domain
HZ306_RS06655	COG0039	L-malate dehydrogenase activity
HZ306_RS06660	COG2261	transglycosylase associated protein
HZ306_RS06670	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HZ306_RS06675	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HZ306_RS06680	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HZ306_RS06690	COG0488	(ABC) transporter
HZ306_RS06700	COG1619	proteins homologs of microcin C7 resistance protein MccF
HZ306_RS06705	COG4166	transmembrane transport
HZ306_RS06715	COG4608	Belongs to the ABC transporter superfamily
HZ306_RS06720	COG0444	Belongs to the ABC transporter superfamily
HZ306_RS06725	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HZ306_RS06730	COG0601	transmembrane transport
HZ306_RS06760	COG4988	ABC transporter
HZ306_RS06765	COG1294	oxidase, subunit
HZ306_RS06770	COG1271	oxidase subunit
HZ306_RS06775	COG1959	2 iron, 2 sulfur cluster binding
HZ306_RS06780	COG0521	Mo-molybdopterin cofactor biosynthetic process
HZ306_RS06785	COG0726	polysaccharide deacetylase
HZ306_RS06830	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HZ306_RS06840	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HZ306_RS06845	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HZ306_RS06855	COG0419	ATPase involved in DNA repair
HZ306_RS06860	COG0420	3'-5' exonuclease activity
HZ306_RS06865	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HZ306_RS06870	COG0735	belongs to the Fur family
HZ306_RS06875	COG0513	Belongs to the DEAD box helicase family
HZ306_RS06900	COG1012	belongs to the aldehyde dehydrogenase family
HZ306_RS06905	COG2183	response to ionizing radiation
HZ306_RS06910	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HZ306_RS06915	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HZ306_RS06920	COG0514	ATP-dependent DNA helicase (RecQ)
HZ306_RS06925	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HZ306_RS06935	COG4797	methyltransferase
HZ306_RS06935	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HZ306_RS06945	COG0583	DNA-binding transcription factor activity
HZ306_RS06980	COG2301	Belongs to the HpcH HpaI aldolase family
HZ306_RS06985	COG3052	prosthetic group binding
HZ306_RS06990	COG0471	metal ion transport
HZ306_RS06995	COG0583	DNA-binding transcription factor activity
HZ306_RS07000	COG0670	Belongs to the BI1 family
HZ306_RS07050	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HZ306_RS07055	COG0113	porphobilinogen synthase activity
HZ306_RS07060	COG1587	Uroporphyrinogen-III synthase
HZ306_RS07060	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HZ306_RS07070	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HZ306_RS07075	COG1648	precorrin-2 dehydrogenase activity
HZ306_RS07075	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HZ306_RS07080	COG2302	S4 RNA-binding domain
HZ306_RS07085	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HZ306_RS07090	COG1799	cell septum assembly
HZ306_RS07105	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HZ306_RS07110	COG2323	membrane
HZ306_RS07125	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HZ306_RS07130	COG1119	ATPase activity
HZ306_RS07140	COG0028	Belongs to the TPP enzyme family
HZ306_RS07145	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HZ306_RS07150	COG0129	dihydroxy-acid dehydratase activity
HZ306_RS07155	COG0471	metal ion transport
HZ306_RS07160	COG0662	Cupin 2, conserved barrel domain protein
HZ306_RS07170	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HZ306_RS07175	COG0363	glucosamine-6-phosphate deaminase activity
HZ306_RS07180	COG1024	Enoyl-CoA hydratase
HZ306_RS07185	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HZ306_RS07190	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HZ306_RS07195	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HZ306_RS07200	COG0583	DNA-binding transcription factor activity
HZ306_RS07205	COG1742	UPF0060 membrane protein
HZ306_RS07265	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HZ306_RS07270	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HZ306_RS07275	COG0287	Prephenate dehydrogenase
HZ306_RS07280	COG0534	Mate efflux family protein
HZ306_RS07295	COG1013	pyruvate-flavodoxin oxidoreductase activity
HZ306_RS07300	COG0674	pyruvate-flavodoxin oxidoreductase activity
HZ306_RS07300	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HZ306_RS07310	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HZ306_RS07320	COG1122	ATPase activity
HZ306_RS07325	COG0203	ribosomal protein L17
HZ306_RS07330	COG0202	RNA polymerase activity
HZ306_RS07340	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HZ306_RS07345	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HZ306_RS07365	COG0201	protein transport
HZ306_RS07370	COG0200	Binds to the 23S rRNA
HZ306_RS07375	COG1841	ribosomal large subunit assembly
HZ306_RS07380	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HZ306_RS07385	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HZ306_RS07395	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HZ306_RS07405	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HZ306_RS07415	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HZ306_RS07425	COG0255	Belongs to the universal ribosomal protein uL29 family
HZ306_RS07430	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HZ306_RS07435	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HZ306_RS07440	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HZ306_RS07445	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HZ306_RS07450	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HZ306_RS07460	COG0088	Forms part of the polypeptide exit tunnel
HZ306_RS07465	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HZ306_RS07470	COG0051	transcription antitermination factor activity, RNA binding
HZ306_RS07475	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HZ306_RS07485	COG0049	tRNA binding
HZ306_RS07490	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HZ306_RS07500	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HZ306_RS07505	COG0085	RNA polymerase activity
HZ306_RS07510	COG1027	Aspartate ammonia-lyase
HZ306_RS07515	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HZ306_RS07525	COG0222	ribosome binding
HZ306_RS07535	COG0081	regulation of translation
HZ306_RS07540	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HZ306_RS07545	COG0250	Participates in transcription elongation, termination and antitermination
HZ306_RS07550	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HZ306_RS07555	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HZ306_RS07565	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HZ306_RS07610	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HZ306_RS07620	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HZ306_RS07625	COG0768	penicillin binding
HZ306_RS07630	COG0617	tRNA 3'-terminal CCA addition
HZ306_RS07635	COG1760	l-serine dehydratase
HZ306_RS07640	COG1760	l-serine dehydratase
HZ306_RS07645	COG1151	hydroxylamine reductase activity
HZ306_RS07700	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HZ306_RS07715	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HZ306_RS07720	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HZ306_RS07725	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HZ306_RS07730	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HZ306_RS07735	COG0356	it plays a direct role in the translocation of protons across the membrane
HZ306_RS07750	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HZ306_RS07755	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HZ306_RS07760	COG2848	UPF0210 protein
HZ306_RS07765	COG3830	Belongs to the UPF0237 family
HZ306_RS07770	COG0033	Phosphoglucomutase
HZ306_RS07775	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HZ306_RS07780	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HZ306_RS07785	COG1802	Transcriptional regulator
HZ306_RS07790	COG1115	amino acid carrier protein
HZ306_RS07795	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HZ306_RS07815	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HZ306_RS07820	COG0708	Exodeoxyribonuclease III
HZ306_RS07940	COG2946	Replication initiation factor
HZ306_RS07950	COG1674	ftsk spoiiie
HZ306_RS07990	COG0747	negative chemotaxis
HZ306_RS08000	COG0444	Belongs to the ABC transporter superfamily
HZ306_RS08005	COG0747	negative chemotaxis
HZ306_RS08020	COG0531	amino acid
HZ306_RS08025	COG0165	Argininosuccinate lyase
HZ306_RS08030	COG0137	argininosuccinate synthase activity
HZ306_RS08060	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HZ306_RS08065	COG1757	Na H antiporter
HZ306_RS08070	COG1105	Belongs to the carbohydrate kinase PfkB family
HZ306_RS08075	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HZ306_RS08075	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZ306_RS08075	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HZ306_RS08105	COG0450	alkyl hydroperoxide reductase
HZ306_RS08115	COG0504	CTP synthase activity
HZ306_RS08120	COG0018	arginyl-trna synthetase
HZ306_RS08145	COG0561	phosphatase activity
HZ306_RS08155	COG0371	Dehydrogenase
HZ306_RS08160	COG1114	Component of the transport system for branched-chain amino acids
HZ306_RS08165	COG0243	molybdopterin cofactor binding
HZ306_RS08170	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HZ306_RS08175	COG1620	l-lactate permease
HZ306_RS08185	COG2814	Major facilitator Superfamily
HZ306_RS08205	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
HZ306_RS08215	COG4820	ethanolamine utilization protein (EutJ)
HZ306_RS08220	COG4869	propanediol catabolic process
HZ306_RS08245	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HZ306_RS08260	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HZ306_RS08315	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HZ306_RS08335	COG1454	alcohol dehydrogenase
HZ306_RS08350	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HZ306_RS08355	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HZ306_RS08375	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HZ306_RS08380	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HZ306_RS08385	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HZ306_RS08390	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HZ306_RS08395	COG0077	Prephenate dehydratase
HZ306_RS08395	COG1605	Chorismate mutase
HZ306_RS08415	COG0710	3-dehydroquinate dehydratase activity
HZ306_RS08420	COG2814	Major facilitator Superfamily
HZ306_RS08425	COG1959	2 iron, 2 sulfur cluster binding
HZ306_RS08430	COG2252	PERMEase
HZ306_RS08455	COG1113	amino acid transport
HZ306_RS08470	COG0564	pseudouridine synthase activity
HZ306_RS08485	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HZ306_RS08490	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HZ306_RS08495	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HZ306_RS08505	COG0067	glutamate synthase
HZ306_RS08505	COG0069	glutamate synthase activity
HZ306_RS08505	COG0070	glutamate synthase
HZ306_RS08510	COG0564	pseudouridine synthase activity
HZ306_RS08525	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HZ306_RS08530	COG0656	L-ascorbic acid biosynthetic process
HZ306_RS08535	COG1687	branched-chain amino acid
HZ306_RS08540	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HZ306_RS08545	COG1979	alcohol dehydrogenase
HZ306_RS08565	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
HZ306_RS08565	COG0778	Nitroreductase
HZ306_RS08570	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HZ306_RS08570	COG2146	nitrite reductase [NAD(P)H] activity
HZ306_RS08580	COG1556	Lactate utilization protein
HZ306_RS08585	COG1139	Iron-sulfur cluster binding protein
HZ306_RS08590	COG0247	lactate metabolic process
HZ306_RS08600	COG3266	domain, Protein
HZ306_RS08600	COG1361	Conserved repeat domain
HZ306_RS08600	COG2911	Protein conserved in bacteria
HZ306_RS08610	COG1297	OPT oligopeptide transporter protein
HZ306_RS08620	COG1408	metallophosphoesterase
HZ306_RS08655	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HZ306_RS08670	COG1597	lipid kinase activity
HZ306_RS08675	COG1074	ATP-dependent DNA helicase activity
HZ306_RS08680	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
HZ306_RS08780	COG3209	COG3209 Rhs family protein
HZ306_RS08830	COG3209	COG3209 Rhs family protein
HZ306_RS08900	COG2801	Transposase and inactivated derivatives
HZ306_RS08915	COG2217	Heavy metal translocating P-type atpase
HZ306_RS08925	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HZ306_RS08930	COG0305	Participates in initiation and elongation during chromosome replication
HZ306_RS08935	COG0359	binds to the 23S rRNA
HZ306_RS08940	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
HZ306_RS08965	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HZ306_RS08975	COG1116	anion transmembrane transporter activity
HZ306_RS08975	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HZ306_RS08980	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HZ306_RS08985	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HZ306_RS08990	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HZ306_RS08995	COG0586	Pfam SNARE associated Golgi protein
HZ306_RS09010	COG0515	serine threonine protein kinase
HZ306_RS09015	COG2048	Heterodisulfide reductase, subunit B
HZ306_RS09020	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HZ306_RS09025	COG1053	succinate dehydrogenase
HZ306_RS09035	COG5002	protein histidine kinase activity
HZ306_RS09035	COG3850	Histidine kinase
HZ306_RS09040	COG2733	membrane
HZ306_RS09045	COG2733	membrane
HZ306_RS09055	COG1733	regulation of RNA biosynthetic process
HZ306_RS09060	COG2910	NAD(P)H-binding
HZ306_RS09070	COG0280	phosphate acetyltransferase
HZ306_RS09075	COG1373	ATPase (AAA superfamily
HZ306_RS09090	COG0493	'glutamate synthase
HZ306_RS09095	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HZ306_RS09125	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HZ306_RS09135	COG2824	Alkylphosphonate utilization operon protein PhnA
HZ306_RS09140	COG0789	Transcriptional regulator
HZ306_RS09230	COG2826	transposase and inactivated derivatives, IS30 family
HZ306_RS09250	COG0753	catalase activity
HZ306_RS09260	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HZ306_RS09270	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HZ306_RS09280	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HZ306_RS09300	COG0848	biopolymer transport protein
HZ306_RS09305	COG0811	peptide transport
HZ306_RS09325	COG1703	isobutyryl-CoA mutase activity
HZ306_RS09330	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HZ306_RS09330	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HZ306_RS09335	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HZ306_RS09335	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HZ306_RS09340	COG2962	Rard protein
HZ306_RS09370	COG0277	FAD linked oxidase domain protein
HZ306_RS09385	COG1454	alcohol dehydrogenase
HZ306_RS09420	COG1846	Transcriptional regulator
HZ306_RS09445	COG1393	Belongs to the ArsC family
HZ306_RS09455	COG3549	Plasmid maintenance system killer
HZ306_RS09465	COG0519	Catalyzes the synthesis of GMP from XMP
HZ306_RS09530	COG3069	C4-dicarboxylate transmembrane transporter activity
HZ306_RS09535	COG2195	Cleaves the N-terminal amino acid of tripeptides
HZ306_RS09610	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HZ306_RS09615	COG1373	ATPase (AAA superfamily
HZ306_RS09630	COG1489	DNA binding
HZ306_RS09645	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HZ306_RS09680	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HZ306_RS09685	COG0741	lytic transglycosylase activity
HZ306_RS09685	COG0739	heme binding
HZ306_RS09685	COG1196	nuclear chromosome segregation
HZ306_RS09695	COG1160	GTP binding
HZ306_RS09700	COG1475	DNA binding
HZ306_RS09705	COG1192	Involved in chromosome partitioning
HZ306_RS09720	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HZ306_RS09720	COG0646	methionine synthase
HZ306_RS09730	COG0357	Ribosomal RNA small subunit methyltransferase G
HZ306_RS09745	COG0445	tRNA wobble uridine modification
HZ306_RS09750	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HZ306_RS09755	COG1847	R3H domain protein
HZ306_RS09760	COG0706	membrane insertase activity
HZ306_RS09765	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HZ306_RS09770	COG0594	ribonuclease P activity
HZ306_RS09775	COG0230	Belongs to the bacterial ribosomal protein bL34 family