locus-tag	class	description
L21SP4_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
L21SP4_RS00010	COG0592	DNA-directed DNA polymerase activity
L21SP4_RS00030	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
L21SP4_RS00035	COG1295	ribonuclease BN
L21SP4_RS00055	COG0232	Belongs to the dGTPase family. Type 2 subfamily
L21SP4_RS00065	COG0191	fructose-bisphosphate aldolase activity
L21SP4_RS00070	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
L21SP4_RS00075	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
L21SP4_RS00090	COG0129	dihydroxy-acid dehydratase activity
L21SP4_RS00095	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
L21SP4_RS00105	COG0071	Belongs to the small heat shock protein (HSP20) family
L21SP4_RS00110	COG0071	Belongs to the small heat shock protein (HSP20) family
L21SP4_RS00120	COG0254	rRNA binding
L21SP4_RS00125	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
L21SP4_RS00130	COG0445	tRNA wobble uridine modification
L21SP4_RS00135	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
L21SP4_RS00140	COG0517	IMP dehydrogenase activity
L21SP4_RS00145	COG0357	Ribosomal RNA small subunit methyltransferase G
L21SP4_RS00150	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
L21SP4_RS00165	COG2890	protein-(glutamine-N5) methyltransferase activity
L21SP4_RS00170	COG0697	spore germination
L21SP4_RS00185	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
L21SP4_RS00200	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
L21SP4_RS00220	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
L21SP4_RS00275	COG1606	tRNA processing
L21SP4_RS00280	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L21SP4_RS00310	COG0195	Participates in both transcription termination and antitermination
L21SP4_RS00315	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
L21SP4_RS00315	COG3170	Tfp pilus assembly protein FimV
L21SP4_RS00325	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
L21SP4_RS00330	COG0196	riboflavin kinase activity
L21SP4_RS00335	COG1067	ATP-dependent peptidase activity
L21SP4_RS00340	COG0530	calcium, potassium:sodium antiporter activity
L21SP4_RS00345	COG0504	CTP synthase activity
L21SP4_RS00350	COG0546	phosphoglycolate phosphatase activity
L21SP4_RS00370	COG3344	reverse transcriptase
L21SP4_RS00375	COG3119	arylsulfatase activity
L21SP4_RS00390	COG0848	biopolymer transport protein
L21SP4_RS00400	COG0811	peptide transport
L21SP4_RS00420	COG1058	Belongs to the CinA family
L21SP4_RS00420	COG1546	Belongs to the CinA family
L21SP4_RS00425	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
L21SP4_RS00440	COG2223	nitrite transmembrane transporter activity
L21SP4_RS00445	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
L21SP4_RS00460	COG0784	Response regulator, receiver
L21SP4_RS00460	COG4191	Histidine kinase
L21SP4_RS00470	COG0714	Associated with various cellular activities
L21SP4_RS00505	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
L21SP4_RS00510	COG0228	four-way junction DNA binding
L21SP4_RS00515	COG1837	Belongs to the UPF0109 family
L21SP4_RS00525	COG0335	large ribosomal subunit rRNA binding
L21SP4_RS00530	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
L21SP4_RS00535	COG0792	nuclease activity
L21SP4_RS00545	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
L21SP4_RS00545	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
L21SP4_RS00585	COG0489	protein tyrosine kinase activity
L21SP4_RS00585	COG2151	metal-sulfur cluster biosynthetic enzyme
L21SP4_RS00605	COG2204	response regulator
L21SP4_RS00620	COG4133	protoheme IX ABC transporter activity
L21SP4_RS00630	COG0318	PFAM AMP-dependent synthetase and ligase
L21SP4_RS00650	COG0477	Major facilitator Superfamily
L21SP4_RS00650	COG2814	Major facilitator Superfamily
L21SP4_RS00680	COG3119	arylsulfatase activity
L21SP4_RS00690	COG3209	COG3209 Rhs family protein
L21SP4_RS00700	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
L21SP4_RS00705	COG1881	PFAM PEBP family protein
L21SP4_RS00710	COG1515	deoxyribonuclease V activity
L21SP4_RS00730	COG0730	response to heat
L21SP4_RS00750	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
L21SP4_RS00760	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
L21SP4_RS00805	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
L21SP4_RS00825	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
L21SP4_RS00840	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
L21SP4_RS00895	COG0641	radical SAM
L21SP4_RS00920	COG0330	HflC and HflK could
L21SP4_RS00960	COG1216	Glycosyl transferase, family 2
L21SP4_RS00960	COG1442	glycosyl transferase family 8
L21SP4_RS00975	COG0463	Glycosyl transferase, family 2
L21SP4_RS00980	COG0438	transferase activity, transferring glycosyl groups
L21SP4_RS00990	COG0489	protein tyrosine kinase activity
L21SP4_RS01005	COG0194	GDP metabolic process
L21SP4_RS01010	COG1561	YicC-like family, N-terminal region
L21SP4_RS01015	COG0133	tryptophan synthase activity
L21SP4_RS01020	COG0135	phosphoribosylanthranilate isomerase activity
L21SP4_RS01025	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
L21SP4_RS01030	COG0515	serine threonine protein kinase
L21SP4_RS01040	COG1396	sequence-specific DNA binding
L21SP4_RS01045	COG3550	peptidyl-serine autophosphorylation
L21SP4_RS01050	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
L21SP4_RS01065	COG0673	inositol 2-dehydrogenase activity
L21SP4_RS01075	COG0673	inositol 2-dehydrogenase activity
L21SP4_RS01105	COG1215	transferase activity, transferring glycosyl groups
L21SP4_RS01115	COG1773	rubredoxin
L21SP4_RS01120	COG0261	This protein binds to 23S rRNA in the presence of protein L20
L21SP4_RS01125	COG0211	Belongs to the bacterial ribosomal protein bL27 family
L21SP4_RS01145	COG0475	glutathione-regulated potassium exporter activity
L21SP4_RS01155	COG0333	Belongs to the bacterial ribosomal protein bL32 family
L21SP4_RS01160	COG0416	fatty acid biosynthetic process
L21SP4_RS01165	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L21SP4_RS01170	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
L21SP4_RS01175	COG1028	Short-chain dehydrogenase reductase Sdr
L21SP4_RS01180	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L21SP4_RS01185	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L21SP4_RS01190	COG0415	Belongs to the DNA photolyase family
L21SP4_RS01220	COG1131	(ABC) transporter
L21SP4_RS01225	COG0733	neurotransmitter:sodium symporter activity
L21SP4_RS01230	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
L21SP4_RS01245	COG4191	Histidine kinase
L21SP4_RS01245	COG0784	Response regulator, receiver
L21SP4_RS01260	COG3344	reverse transcriptase
L21SP4_RS01285	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L21SP4_RS01295	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L21SP4_RS01300	COG1459	type II secretion system
L21SP4_RS01305	COG2204	response regulator
L21SP4_RS01310	COG3852	Histidine kinase
L21SP4_RS01315	COG1459	type II secretion system
L21SP4_RS01320	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L21SP4_RS01335	COG3409	Peptidoglycan-binding domain 1 protein
L21SP4_RS01335	COG3267	Type II secretory pathway component ExeA
L21SP4_RS01385	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L21SP4_RS01395	COG0242	peptide deformylase activity
L21SP4_RS01415	COG0745	RESPONSE REGULATOR receiver
L21SP4_RS01420	COG5002	protein histidine kinase activity
L21SP4_RS01425	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
L21SP4_RS01430	COG0573	inorganic phosphate transmembrane transporter activity
L21SP4_RS01435	COG0581	inorganic phosphate transmembrane transporter activity
L21SP4_RS01440	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
L21SP4_RS01445	COG0704	Plays a role in the regulation of phosphate uptake
L21SP4_RS01450	COG0436	Aminotransferase
L21SP4_RS01475	COG0640	Transcriptional regulator
L21SP4_RS01500	COG3118	belongs to the thioredoxin family
L21SP4_RS01505	COG0396	ATPase activity
L21SP4_RS01510	COG0719	Fe-S assembly protein
L21SP4_RS01520	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
L21SP4_RS01530	COG0815	Transfers the fatty acyl group on membrane lipoproteins
L21SP4_RS01560	COG3940	Belongs to the glycosyl hydrolase 43 family
L21SP4_RS01580	COG4537	Required for transformation and DNA binding
L21SP4_RS01600	COG3119	arylsulfatase activity
L21SP4_RS01600	COG3408	Glycogen debranching enzyme
L21SP4_RS01610	COG0395	ABC-type sugar transport system, permease component
L21SP4_RS01615	COG2207	Transcriptional regulator
L21SP4_RS01620	COG5012	cobalamin binding
L21SP4_RS01625	COG0590	tRNA wobble adenosine to inosine editing
L21SP4_RS01650	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
L21SP4_RS01650	COG0646	methionine synthase
L21SP4_RS01655	COG0167	dihydroorotate dehydrogenase activity
L21SP4_RS01660	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
L21SP4_RS01660	COG1013	pyruvate-flavodoxin oxidoreductase activity
L21SP4_RS01660	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
L21SP4_RS01660	COG0674	pyruvate-flavodoxin oxidoreductase activity
L21SP4_RS01685	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
L21SP4_RS01690	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
L21SP4_RS01700	COG0776	regulation of translation
L21SP4_RS01705	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L21SP4_RS01705	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
L21SP4_RS01705	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L21SP4_RS01710	COG0475	glutathione-regulated potassium exporter activity
L21SP4_RS01720	COG1560	Kdo2-lipid A biosynthetic process
L21SP4_RS01725	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
L21SP4_RS01730	COG1691	(AIR) carboxylase
L21SP4_RS01735	COG0653	protein targeting
L21SP4_RS01745	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
L21SP4_RS01755	COG3119	arylsulfatase activity
L21SP4_RS01760	COG4537	Required for transformation and DNA binding
L21SP4_RS01765	COG3119	arylsulfatase activity
L21SP4_RS01775	COG3119	arylsulfatase activity
L21SP4_RS01780	COG1609	Transcriptional regulator
L21SP4_RS01800	COG3046	protein related to deoxyribodipyrimidine photolyase
L21SP4_RS01805	COG0667	Aldo Keto reductase
L21SP4_RS01825	COG3119	arylsulfatase activity
L21SP4_RS01835	COG1472	Belongs to the glycosyl hydrolase 3 family
L21SP4_RS01845	COG1484	DNA-dependent DNA replication
L21SP4_RS01855	COG3408	Glycogen debranching enzyme
L21SP4_RS01885	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
L21SP4_RS01905	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
L21SP4_RS01915	COG1349	DNA-binding transcription factor activity
L21SP4_RS01920	COG0517	IMP dehydrogenase activity
L21SP4_RS01920	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
L21SP4_RS01940	COG0477	Major facilitator Superfamily
L21SP4_RS01940	COG2814	Major facilitator Superfamily
L21SP4_RS01950	COG3119	arylsulfatase activity
L21SP4_RS01955	COG3408	Glycogen debranching enzyme
L21SP4_RS01975	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
L21SP4_RS01980	COG2115	Belongs to the xylose isomerase family
L21SP4_RS02000	COG2211	Major facilitator Superfamily
L21SP4_RS02005	COG2211	Major facilitator Superfamily
L21SP4_RS02010	COG3119	arylsulfatase activity
L21SP4_RS02015	COG3940	Belongs to the glycosyl hydrolase 43 family
L21SP4_RS02035	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
L21SP4_RS02050	COG3119	arylsulfatase activity
L21SP4_RS02055	COG3119	arylsulfatase activity
L21SP4_RS02070	COG1609	Transcriptional regulator
L21SP4_RS02075	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
L21SP4_RS02095	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
L21SP4_RS02100	COG3119	arylsulfatase activity
L21SP4_RS02105	COG1960	acyl-CoA dehydrogenase activity
L21SP4_RS02125	COG1132	(ABC) transporter
L21SP4_RS02130	COG0492	ferredoxin-NADP+ reductase activity
L21SP4_RS02140	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
L21SP4_RS02145	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
L21SP4_RS02150	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
L21SP4_RS02155	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
L21SP4_RS02160	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L21SP4_RS02165	COG0137	argininosuccinate synthase activity
L21SP4_RS02170	COG0019	diaminopimelate decarboxylase activity
L21SP4_RS02175	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L21SP4_RS02180	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
L21SP4_RS02195	COG0322	excinuclease ABC activity
L21SP4_RS02200	COG1434	Gram-negative-bacterium-type cell wall biogenesis
L21SP4_RS02205	COG0540	Belongs to the ATCase OTCase family
L21SP4_RS02220	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
L21SP4_RS02250	COG0423	glycine-tRNA ligase activity
L21SP4_RS02275	COG4806	L-rhamnose isomerase
L21SP4_RS02280	COG1181	Belongs to the D-alanine--D-alanine ligase family
L21SP4_RS02290	COG0849	cell division
L21SP4_RS02295	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
L21SP4_RS02300	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L21SP4_RS02315	COG1968	undecaprenyl-diphosphatase activity
L21SP4_RS02325	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
L21SP4_RS02330	COG1929	Belongs to the glycerate kinase type-1 family
L21SP4_RS02340	COG0517	IMP dehydrogenase activity
L21SP4_RS02340	COG1994	Peptidase M50
L21SP4_RS02345	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L21SP4_RS02345	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
L21SP4_RS02350	COG3119	arylsulfatase activity
L21SP4_RS02365	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
L21SP4_RS02370	COG1322	Protein conserved in bacteria
L21SP4_RS02385	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L21SP4_RS02395	COG0358	DNA primase activity
L21SP4_RS02405	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
L21SP4_RS02410	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
L21SP4_RS02415	COG0366	Alpha amylase catalytic
L21SP4_RS02420	COG0058	SHG alpha-glucan phosphorylase activity
L21SP4_RS02425	COG0297	glycogen (starch) synthase activity
L21SP4_RS02430	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
L21SP4_RS02440	COG0589	response to stress
L21SP4_RS02445	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
L21SP4_RS02480	COG0539	negative regulation of cytoplasmic translation
L21SP4_RS02480	COG2183	response to ionizing radiation
L21SP4_RS02485	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
L21SP4_RS02490	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
L21SP4_RS02495	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
L21SP4_RS02500	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L21SP4_RS02520	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
L21SP4_RS02525	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
L21SP4_RS02535	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
L21SP4_RS02540	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
L21SP4_RS02560	COG3119	arylsulfatase activity
L21SP4_RS02565	COG0194	GDP metabolic process
L21SP4_RS02570	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
L21SP4_RS02580	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L21SP4_RS02585	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
L21SP4_RS02595	COG3940	Belongs to the glycosyl hydrolase 43 family
L21SP4_RS02600	COG0072	phenylalanine-tRNA ligase activity
L21SP4_RS02605	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L21SP4_RS02610	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L21SP4_RS02620	COG3408	Glycogen debranching enzyme
L21SP4_RS02630	COG3119	arylsulfatase activity
L21SP4_RS02665	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
L21SP4_RS02695	COG0230	Belongs to the bacterial ribosomal protein bL34 family
L21SP4_RS02700	COG0594	ribonuclease P activity
L21SP4_RS02705	COG0706	membrane insertase activity
L21SP4_RS02720	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L21SP4_RS02730	COG2264	protein methyltransferase activity
L21SP4_RS02740	COG0126	phosphoglycerate kinase activity
L21SP4_RS02745	COG0149	triose-phosphate isomerase activity
L21SP4_RS02765	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L21SP4_RS02780	COG0546	phosphoglycolate phosphatase activity
L21SP4_RS02790	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L21SP4_RS02805	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
L21SP4_RS02835	COG1477	protein flavinylation
L21SP4_RS02840	COG2871	sodium ion transport
L21SP4_RS02845	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
L21SP4_RS02850	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
L21SP4_RS02855	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
L21SP4_RS02860	COG1805	sodium ion transport
L21SP4_RS02900	COG0300	oxidoreductase activity
L21SP4_RS02905	COG0107	imidazoleglycerol-phosphate synthase activity
L21SP4_RS02910	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
L21SP4_RS02915	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
L21SP4_RS02925	COG0084	hydrolase, TatD family'
L21SP4_RS02940	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
L21SP4_RS02955	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L21SP4_RS02955	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L21SP4_RS02960	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
L21SP4_RS02970	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
L21SP4_RS02975	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L21SP4_RS02995	COG0438	transferase activity, transferring glycosyl groups
L21SP4_RS03000	COG0438	transferase activity, transferring glycosyl groups
L21SP4_RS03005	COG0745	RESPONSE REGULATOR receiver
L21SP4_RS03015	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
L21SP4_RS03030	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
L21SP4_RS03045	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
L21SP4_RS03050	COG1366	Belongs to the anti-sigma-factor antagonist family
L21SP4_RS03085	COG0110	maltose O-acetyltransferase activity
L21SP4_RS03095	COG0438	transferase activity, transferring glycosyl groups
L21SP4_RS03105	COG1045	serine acetyltransferase
L21SP4_RS03110	COG0438	transferase activity, transferring glycosyl groups
L21SP4_RS03115	COG0438	transferase activity, transferring glycosyl groups
L21SP4_RS03120	COG0110	maltose O-acetyltransferase activity
L21SP4_RS03125	COG1215	transferase activity, transferring glycosyl groups
L21SP4_RS03160	COG1028	Short-chain dehydrogenase reductase Sdr
L21SP4_RS03165	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
L21SP4_RS03175	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
L21SP4_RS03185	COG1904	glucuronate isomerase
L21SP4_RS03195	COG0488	(ABC) transporter
L21SP4_RS03215	COG2319	Wd-40 repeat
L21SP4_RS03215	COG4249	Peptidase C14 caspase catalytic subunit p20
L21SP4_RS03240	COG0732	type I restriction modification DNA specificity domain
L21SP4_RS03245	COG3586	endonuclease activity
L21SP4_RS03250	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
L21SP4_RS03300	COG3012	SEC-C Motif Domain Protein
L21SP4_RS03315	COG1484	DNA-dependent DNA replication
L21SP4_RS03345	COG1278	Cold shock
L21SP4_RS03465	COG0583	DNA-binding transcription factor activity
L21SP4_RS03470	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
L21SP4_RS03475	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
L21SP4_RS03490	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L21SP4_RS03495	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L21SP4_RS03525	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
L21SP4_RS03535	COG1459	type II secretion system
L21SP4_RS03590	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L21SP4_RS03600	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
L21SP4_RS03605	COG1127	ABC transporter
L21SP4_RS03630	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
L21SP4_RS03640	COG0528	UMP kinase activity
L21SP4_RS03655	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
L21SP4_RS03660	COG4191	Histidine kinase
L21SP4_RS03665	COG2204	response regulator
L21SP4_RS03670	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L21SP4_RS03680	COG0531	amino acid
L21SP4_RS03685	COG1045	serine acetyltransferase
L21SP4_RS03705	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
L21SP4_RS03715	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L21SP4_RS03740	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
L21SP4_RS03770	COG0542	response to heat
L21SP4_RS03775	COG0268	Binds directly to 16S ribosomal RNA
L21SP4_RS03790	COG3119	arylsulfatase activity
L21SP4_RS03795	COG3119	arylsulfatase activity
L21SP4_RS03800	COG1501	Belongs to the glycosyl hydrolase 31 family
L21SP4_RS03805	COG0477	Major facilitator Superfamily
L21SP4_RS03820	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
L21SP4_RS03820	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
L21SP4_RS03825	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
L21SP4_RS03830	COG2877	3-deoxy-8-phosphooctulonate synthase activity
L21SP4_RS03850	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
L21SP4_RS03860	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
L21SP4_RS03865	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
L21SP4_RS03885	COG0343	queuine tRNA-ribosyltransferase activity
L21SP4_RS03890	COG1862	Preprotein translocase
L21SP4_RS03895	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L21SP4_RS03895	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L21SP4_RS03900	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
L21SP4_RS03900	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
L21SP4_RS03920	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
L21SP4_RS03935	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
L21SP4_RS03965	COG0511	ligase activity, forming carbon-carbon bonds
L21SP4_RS03970	COG0439	Biotin carboxylase
L21SP4_RS03985	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
L21SP4_RS03990	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L21SP4_RS04010	COG1966	Carbon starvation protein
L21SP4_RS04025	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
L21SP4_RS04065	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
L21SP4_RS04080	COG0811	peptide transport
L21SP4_RS04085	COG0848	biopolymer transport protein
L21SP4_RS04105	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
L21SP4_RS04115	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L21SP4_RS04120	COG0227	Belongs to the bacterial ribosomal protein bL28 family
L21SP4_RS04125	COG0372	Belongs to the citrate synthase family
L21SP4_RS04145	COG0728	peptidoglycan biosynthetic process
L21SP4_RS04160	COG0668	transmembrane transport
L21SP4_RS04165	COG0793	Belongs to the peptidase S41A family
L21SP4_RS04170	COG0166	Belongs to the GPI family
L21SP4_RS04175	COG3119	arylsulfatase activity
L21SP4_RS04180	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
L21SP4_RS04200	COG1028	Short-chain dehydrogenase reductase Sdr
L21SP4_RS04215	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
L21SP4_RS04225	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
L21SP4_RS04230	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
L21SP4_RS04235	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
L21SP4_RS04240	COG0784	Response regulator, receiver
L21SP4_RS04240	COG2205	protein histidine kinase activity
L21SP4_RS04245	COG2003	Belongs to the UPF0758 family
L21SP4_RS04250	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L21SP4_RS04255	COG2176	DNA-directed DNA polymerase activity
L21SP4_RS04265	COG1597	lipid kinase activity
L21SP4_RS04275	COG1830	Aldolase
L21SP4_RS04310	COG1592	Rubrerythrin
L21SP4_RS04320	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
L21SP4_RS04325	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L21SP4_RS04325	COG0519	Catalyzes the synthesis of GMP from XMP
L21SP4_RS04330	COG0505	Belongs to the CarA family
L21SP4_RS04335	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L21SP4_RS04345	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
L21SP4_RS04350	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L21SP4_RS04355	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
L21SP4_RS04360	COG0758	DNA mediated transformation
L21SP4_RS04365	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
L21SP4_RS04375	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L21SP4_RS04380	COG0662	Cupin 2, conserved barrel domain protein
L21SP4_RS04380	COG2207	Transcriptional regulator
L21SP4_RS04415	COG3119	arylsulfatase activity
L21SP4_RS04420	COG3250	beta-galactosidase activity
L21SP4_RS04425	COG3250	beta-galactosidase activity
L21SP4_RS04525	COG3408	Glycogen debranching enzyme
L21SP4_RS04535	COG3119	arylsulfatase activity
L21SP4_RS04570	COG0277	FAD linked oxidase domain protein
L21SP4_RS04575	COG1063	alcohol dehydrogenase
L21SP4_RS04610	COG3119	arylsulfatase activity
L21SP4_RS04615	COG2211	Major facilitator Superfamily
L21SP4_RS04660	COG1480	7TM receptor with intracellular HD hydrolase
L21SP4_RS04665	COG1702	phosphate starvation-inducible protein PhoH
L21SP4_RS04680	COG3177	Filamentation induced by cAMP protein fic
L21SP4_RS04735	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L21SP4_RS04750	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L21SP4_RS04775	COG0561	phosphatase activity
L21SP4_RS04775	COG3100	YcgL domain-containing protein
L21SP4_RS04785	COG4191	Histidine kinase
L21SP4_RS04790	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L21SP4_RS04800	COG2135	peptidase activity
L21SP4_RS04830	COG0018	arginyl-trna synthetase
L21SP4_RS04845	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
L21SP4_RS04850	COG0564	pseudouridine synthase activity
L21SP4_RS04855	COG0538	isocitrate dehydrogenase activity
L21SP4_RS04870	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
L21SP4_RS04890	COG0793	Belongs to the peptidase S41A family
L21SP4_RS04895	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
L21SP4_RS04905	COG1792	Involved in formation and maintenance of cell shape
L21SP4_RS04915	COG0768	penicillin binding
L21SP4_RS04920	COG0772	Belongs to the SEDS family
L21SP4_RS04925	COG1530	ribonuclease E activity
L21SP4_RS04935	COG0714	Associated with various cellular activities
L21SP4_RS04965	COG0180	Tryptophanyl-tRNA synthetase
L21SP4_RS04975	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
L21SP4_RS04980	COG0077	Prephenate dehydratase
L21SP4_RS04980	COG1605	Chorismate mutase
L21SP4_RS04985	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
L21SP4_RS04990	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
L21SP4_RS04995	COG0287	Prephenate dehydrogenase
L21SP4_RS05000	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
L21SP4_RS05005	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
L21SP4_RS05010	COG0442	prolyl-tRNA aminoacylation
L21SP4_RS05025	COG0124	histidyl-tRNA synthetase
L21SP4_RS05030	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
L21SP4_RS05040	COG1388	LysM domain
L21SP4_RS05040	COG0791	NLP P60 protein
L21SP4_RS05055	COG0571	ribonuclease III activity
L21SP4_RS05060	COG4974	Belongs to the 'phage' integrase family
L21SP4_RS05065	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
L21SP4_RS05075	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
L21SP4_RS05080	COG0481	GTPase activity
L21SP4_RS05095	COG0557	exoribonuclease II activity
L21SP4_RS05110	COG2176	DNA-directed DNA polymerase activity
L21SP4_RS05125	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
L21SP4_RS05130	COG1519	Transferase
L21SP4_RS05135	COG4974	Belongs to the 'phage' integrase family
L21SP4_RS05140	COG0778	Nitroreductase
L21SP4_RS05145	COG1254	Belongs to the acylphosphatase family
L21SP4_RS05160	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
L21SP4_RS05165	COG0828	Belongs to the bacterial ribosomal protein bS21 family
L21SP4_RS05180	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
L21SP4_RS05185	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
L21SP4_RS05205	COG0693	protein deglycase activity
L21SP4_RS05215	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
L21SP4_RS05225	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
L21SP4_RS05230	COG0802	atpase or kinase
L21SP4_RS05245	COG2155	Conserved Protein
L21SP4_RS05255	COG0667	Aldo Keto reductase
L21SP4_RS05260	COG3344	reverse transcriptase
L21SP4_RS05265	COG1242	4 iron, 4 sulfur cluster binding
L21SP4_RS05275	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
L21SP4_RS05280	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
L21SP4_RS05295	COG3119	arylsulfatase activity
L21SP4_RS05300	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L21SP4_RS05310	COG0012	GTP binding
L21SP4_RS05325	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
L21SP4_RS05335	COG0668	transmembrane transport
L21SP4_RS05355	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L21SP4_RS05360	COG0101	tRNA pseudouridine synthase activity
L21SP4_RS05365	COG0543	2 iron, 2 sulfur cluster binding
L21SP4_RS05375	COG0363	glucosamine-6-phosphate deaminase activity
L21SP4_RS05380	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
L21SP4_RS05385	COG0720	synthase
L21SP4_RS05390	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
L21SP4_RS05395	COG0602	queuosine metabolic process
L21SP4_RS05400	COG0546	phosphoglycolate phosphatase activity
L21SP4_RS05415	COG0811	peptide transport
L21SP4_RS05420	COG0848	biopolymer transport protein
L21SP4_RS05435	COG1120	ATPase activity
L21SP4_RS05440	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L21SP4_RS05445	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
L21SP4_RS05460	COG1187	pseudouridine synthase activity
L21SP4_RS05470	COG0556	nucleotide-excision repair
L21SP4_RS05480	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
L21SP4_RS05485	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
L21SP4_RS05490	COG0285	dihydrofolate synthase activity
L21SP4_RS05495	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
L21SP4_RS05510	COG0756	dUTP diphosphatase activity
L21SP4_RS05565	COG0673	inositol 2-dehydrogenase activity
L21SP4_RS05580	COG0673	inositol 2-dehydrogenase activity
L21SP4_RS05595	COG0673	inositol 2-dehydrogenase activity
L21SP4_RS05605	COG0402	S-adenosylhomocysteine deaminase activity
L21SP4_RS05615	COG0321	lipoyl(octanoyl) transferase activity
L21SP4_RS05620	COG0509	glycine decarboxylation via glycine cleavage system
L21SP4_RS05630	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
L21SP4_RS05640	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
L21SP4_RS05650	COG0812	UDP-N-acetylmuramate dehydrogenase activity
L21SP4_RS05660	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L21SP4_RS05665	COG0440	acetolactate synthase activity
L21SP4_RS05670	COG0028	Belongs to the TPP enzyme family
L21SP4_RS05690	COG4656	Part of a membrane complex involved in electron transport
L21SP4_RS05695	COG4658	electron transport chain
L21SP4_RS05700	COG4659	FMN binding
L21SP4_RS05705	COG4660	Part of a membrane complex involved in electron transport
L21SP4_RS05710	COG4657	Part of a membrane complex involved in electron transport
L21SP4_RS05715	COG1245	4Fe-4S binding domain
L21SP4_RS05715	COG2878	Part of a membrane complex involved in electron transport
L21SP4_RS05735	COG3385	transposase activity
L21SP4_RS05740	COG0826	peptidase U32
L21SP4_RS05755	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L21SP4_RS05765	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
L21SP4_RS05770	COG0305	Participates in initiation and elongation during chromosome replication
L21SP4_RS05775	COG0359	binds to the 23S rRNA
L21SP4_RS05780	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
L21SP4_RS05785	COG0629	single-stranded DNA binding
L21SP4_RS05795	COG0193	aminoacyl-tRNA hydrolase activity
L21SP4_RS05800	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
L21SP4_RS05825	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
L21SP4_RS05830	COG0217	transcriptional regulatory protein
L21SP4_RS05850	COG0438	transferase activity, transferring glycosyl groups
L21SP4_RS05895	COG0859	PFAM glycosyl transferase family 9
L21SP4_RS05900	COG1663	tetraacyldisaccharide 4'-kinase activity
L21SP4_RS05915	COG1704	LemA family
L21SP4_RS05920	COG0501	Belongs to the peptidase M48B family
L21SP4_RS05930	COG2161	toxin-antitoxin pair type II binding
L21SP4_RS05985	COG3119	arylsulfatase activity
L21SP4_RS06010	COG3119	arylsulfatase activity
L21SP4_RS06015	COG2165	general secretion pathway protein
L21SP4_RS06025	COG3119	arylsulfatase activity
L21SP4_RS06035	COG0673	inositol 2-dehydrogenase activity
L21SP4_RS06070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L21SP4_RS06080	COG1752	Esterase of the alpha-beta hydrolase superfamily
L21SP4_RS06085	COG0641	radical SAM
L21SP4_RS06100	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
L21SP4_RS06105	COG2205	protein histidine kinase activity
L21SP4_RS06105	COG0745	RESPONSE REGULATOR receiver
L21SP4_RS06105	COG3292	Two component regulator propeller
L21SP4_RS06125	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
L21SP4_RS06140	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
L21SP4_RS06145	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
L21SP4_RS06165	COG0165	Argininosuccinate lyase
L21SP4_RS06170	COG1490	D-aminoacyl-tRNA deacylase activity
L21SP4_RS06185	COG1722	exodeoxyribonuclease VII activity
L21SP4_RS06190	COG1570	exodeoxyribonuclease VII activity
L21SP4_RS06195	COG1692	metallophosphoesterase
L21SP4_RS06200	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
L21SP4_RS06205	COG1509	lysine 2,3-aminomutase activity
L21SP4_RS06210	COG0058	SHG alpha-glucan phosphorylase activity
L21SP4_RS06215	COG0205	6-phosphofructokinase activity
L21SP4_RS06230	COG0564	pseudouridine synthase activity
L21SP4_RS06235	COG1573	uracil-dna glycosylase
L21SP4_RS06255	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
L21SP4_RS06260	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
L21SP4_RS06285	COG1028	Short-chain dehydrogenase reductase Sdr
L21SP4_RS06290	COG3956	TIGRFAM MazG family protein
L21SP4_RS06300	COG0724	RNA recognition motif
L21SP4_RS06305	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
L21SP4_RS06310	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
L21SP4_RS06315	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
L21SP4_RS06315	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
L21SP4_RS06320	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L21SP4_RS06320	COG1747	RNA polymerase binding
L21SP4_RS06330	COG0067	glutamate synthase
L21SP4_RS06330	COG0069	glutamate synthase activity
L21SP4_RS06330	COG0070	glutamate synthase
L21SP4_RS06385	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
L21SP4_RS06390	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
L21SP4_RS06400	COG2205	protein histidine kinase activity
L21SP4_RS06400	COG2202	Pas domain
L21SP4_RS06480	COG0330	HflC and HflK could
L21SP4_RS06510	COG3119	arylsulfatase activity
L21SP4_RS06515	COG0477	Major facilitator Superfamily
L21SP4_RS06525	COG0445	tRNA wobble uridine modification
L21SP4_RS06530	COG4537	Required for transformation and DNA binding
L21SP4_RS06535	COG2211	Major facilitator Superfamily
L21SP4_RS06540	COG5434	Belongs to the glycosyl hydrolase 28 family
L21SP4_RS06545	COG3119	arylsulfatase activity
L21SP4_RS06630	COG3119	arylsulfatase activity
L21SP4_RS06635	COG1554	hydrolase, family 65, central catalytic
L21SP4_RS06645	COG1063	alcohol dehydrogenase
L21SP4_RS06655	COG1609	Transcriptional regulator
L21SP4_RS06660	COG0194	GDP metabolic process
L21SP4_RS06670	COG3250	beta-galactosidase activity
L21SP4_RS06680	COG3119	arylsulfatase activity
L21SP4_RS06730	COG3119	arylsulfatase activity
L21SP4_RS06740	COG0291	Belongs to the bacterial ribosomal protein bL35 family
L21SP4_RS06745	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
L21SP4_RS06760	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
L21SP4_RS06780	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
L21SP4_RS06795	COG0347	Belongs to the P(II) protein family
L21SP4_RS06800	COG0004	ammonium transporteR
L21SP4_RS06805	COG1355	regulation of microtubule-based process
L21SP4_RS06820	COG0284	orotidine-5'-phosphate decarboxylase activity
L21SP4_RS06825	COG0131	Imidazoleglycerol-phosphate dehydratase
L21SP4_RS06830	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
L21SP4_RS06865	COG0784	Response regulator, receiver
L21SP4_RS06865	COG4191	Histidine kinase
L21SP4_RS06870	COG1335	isochorismatase
L21SP4_RS06875	COG0724	RNA recognition motif
L21SP4_RS06885	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
L21SP4_RS06895	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
L21SP4_RS06900	COG1758	RNA polymerase activity
L21SP4_RS06905	COG0459	protein refolding
L21SP4_RS06910	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
L21SP4_RS06915	COG0443	Heat shock 70 kDa protein
L21SP4_RS06950	COG0363	glucosamine-6-phosphate deaminase activity
L21SP4_RS06955	COG0428	transporter
L21SP4_RS06960	COG3119	arylsulfatase activity
L21SP4_RS06970	COG4977	sequence-specific DNA binding
L21SP4_RS06975	COG3119	arylsulfatase activity
L21SP4_RS06980	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
L21SP4_RS06985	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L21SP4_RS06995	COG1349	DNA-binding transcription factor activity
L21SP4_RS07000	COG0022	dehydrogenase e1 component
L21SP4_RS07000	COG0508	dehydrogenase complex catalyzes the overall conversion of
L21SP4_RS07005	COG0508	dehydrogenase complex catalyzes the overall conversion of
L21SP4_RS07010	COG0508	dehydrogenase complex catalyzes the overall conversion of
L21SP4_RS07045	COG0326	Molecular chaperone. Has ATPase activity
L21SP4_RS07055	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
L21SP4_RS07065	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
L21SP4_RS07090	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
L21SP4_RS07095	COG0215	cysteine-tRNA ligase activity
L21SP4_RS07100	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
L21SP4_RS07105	COG0740	serine-type endopeptidase activity
L21SP4_RS07110	COG0544	peptidyl-prolyl cis-trans isomerase activity
L21SP4_RS07115	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
L21SP4_RS07120	COG0237	dephospho-CoA kinase activity
L21SP4_RS07125	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
L21SP4_RS07135	COG0159	tryptophan synthase activity
L21SP4_RS07140	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
L21SP4_RS07155	COG0066	3-isopropylmalate dehydratase activity
L21SP4_RS07160	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
L21SP4_RS07165	COG0010	Belongs to the arginase family
L21SP4_RS07180	COG1166	arginine decarboxylase activity
L21SP4_RS07200	COG3119	arylsulfatase activity
L21SP4_RS07225	COG1609	Transcriptional regulator
L21SP4_RS07225	COG2207	Transcriptional regulator
L21SP4_RS07230	COG3344	reverse transcriptase
L21SP4_RS07240	COG3119	arylsulfatase activity
L21SP4_RS07245	COG3119	arylsulfatase activity
L21SP4_RS07250	COG4968	Prepilin-type N-terminal cleavage methylation domain
L21SP4_RS07255	COG3119	arylsulfatase activity
L21SP4_RS07260	COG3119	arylsulfatase activity
L21SP4_RS07265	COG3119	arylsulfatase activity
L21SP4_RS07280	COG0366	Alpha amylase catalytic
L21SP4_RS07285	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
L21SP4_RS07320	COG1070	Carbohydrate kinase
L21SP4_RS07335	COG0084	hydrolase, TatD family'
L21SP4_RS07345	COG0004	ammonium transporteR
L21SP4_RS07350	COG2154	pterin-4-alpha-carbinolamine dehydratase
L21SP4_RS07365	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
L21SP4_RS07370	COG1199	ATP-dependent helicase activity
L21SP4_RS07420	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
L21SP4_RS07425	COG1475	DNA binding
L21SP4_RS07430	COG0501	Belongs to the peptidase M48B family
L21SP4_RS07435	COG0174	glutamine synthetase
L21SP4_RS07450	COG1959	2 iron, 2 sulfur cluster binding
L21SP4_RS07560	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
L21SP4_RS07595	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
L21SP4_RS07605	COG0848	biopolymer transport protein
L21SP4_RS07610	COG0811	peptide transport
L21SP4_RS07615	COG0811	peptide transport
L21SP4_RS07650	COG4771	TonB-dependent receptor
L21SP4_RS07670	COG1136	(ABC) transporter
L21SP4_RS07710	COG1230	cation diffusion facilitator family transporter
L21SP4_RS07735	COG2375	cellular response to nickel ion
L21SP4_RS07735	COG1132	(ABC) transporter
L21SP4_RS07740	COG2375	cellular response to nickel ion
L21SP4_RS07740	COG1132	(ABC) transporter
L21SP4_RS07745	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
L21SP4_RS07785	COG1459	type II secretion system
L21SP4_RS07815	COG2165	general secretion pathway protein
L21SP4_RS07835	COG2165	general secretion pathway protein
L21SP4_RS07860	COG0716	FMN binding
L21SP4_RS07870	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
L21SP4_RS07885	COG1321	iron dependent repressor
L21SP4_RS07900	COG1234	tRNA 3'-trailer cleavage
L21SP4_RS07955	COG0450	alkyl hydroperoxide reductase
L21SP4_RS07965	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L21SP4_RS08000	COG0617	tRNA 3'-terminal CCA addition
L21SP4_RS08005	COG1051	belongs to the nudix hydrolase family
L21SP4_RS08010	COG0530	calcium, potassium:sodium antiporter activity
L21SP4_RS08015	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
L21SP4_RS08015	COG0321	lipoyl(octanoyl) transferase activity
L21SP4_RS08025	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L21SP4_RS08030	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L21SP4_RS08045	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L21SP4_RS08075	COG4771	TonB-dependent receptor
L21SP4_RS08080	COG1185	polyribonucleotide nucleotidyltransferase activity
L21SP4_RS08085	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
L21SP4_RS08090	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
L21SP4_RS08095	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L21SP4_RS08105	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
L21SP4_RS08110	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L21SP4_RS08120	COG1030	water channel activity
L21SP4_RS08125	COG0330	HflC and HflK could
L21SP4_RS08130	COG0531	amino acid
L21SP4_RS08140	COG1151	hydroxylamine reductase activity
L21SP4_RS08205	COG0800	Aldolase
L21SP4_RS08235	COG0482	sulfurtransferase activity
L21SP4_RS08240	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L21SP4_RS08270	COG0203	ribosomal protein L17
L21SP4_RS08275	COG0202	RNA polymerase activity
L21SP4_RS08280	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
L21SP4_RS08290	COG0257	Belongs to the bacterial ribosomal protein bL36 family
L21SP4_RS08305	COG0563	adenylate kinase activity
L21SP4_RS08320	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
L21SP4_RS08325	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
L21SP4_RS08330	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
L21SP4_RS08335	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
L21SP4_RS08340	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
L21SP4_RS08345	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
L21SP4_RS08350	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
L21SP4_RS08355	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
L21SP4_RS08365	COG0255	Belongs to the universal ribosomal protein uL29 family
L21SP4_RS08370	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
L21SP4_RS08375	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
L21SP4_RS08385	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
L21SP4_RS08390	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
L21SP4_RS08395	COG0089	rRNA binding
L21SP4_RS08400	COG0088	Forms part of the polypeptide exit tunnel
L21SP4_RS08410	COG0051	transcription antitermination factor activity, RNA binding
L21SP4_RS08415	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
L21SP4_RS08420	COG0049	tRNA binding
L21SP4_RS08425	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
L21SP4_RS08430	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
L21SP4_RS08435	COG0085	RNA polymerase activity
L21SP4_RS08440	COG0222	ribosome binding
L21SP4_RS08445	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
L21SP4_RS08450	COG0081	regulation of translation
L21SP4_RS08455	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
L21SP4_RS08460	COG0250	Participates in transcription elongation, termination and antitermination
L21SP4_RS08475	COG0267	Belongs to the bacterial ribosomal protein bL33 family
L21SP4_RS08490	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
L21SP4_RS08505	COG0352	thiamine-phosphate diphosphorylase activity
L21SP4_RS08510	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
L21SP4_RS08515	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
L21SP4_RS08520	COG2022	thiamine diphosphate biosynthetic process
L21SP4_RS08540	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
L21SP4_RS08550	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
L21SP4_RS08560	COG0205	6-phosphofructokinase activity
L21SP4_RS08565	COG3842	ATPase activity
L21SP4_RS08575	COG0805	protein transport
L21SP4_RS08580	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
L21SP4_RS08610	COG0772	Belongs to the SEDS family
L21SP4_RS08615	COG1705	Flagellar rod assembly protein muramidase FlgJ
L21SP4_RS08615	COG1388	LysM domain
L21SP4_RS08625	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
L21SP4_RS08630	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
L21SP4_RS08635	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
L21SP4_RS08640	COG0768	penicillin binding
L21SP4_RS08650	COG0275	rRNA processing
L21SP4_RS08655	COG2001	Belongs to the MraZ family
L21SP4_RS08660	COG0820	rRNA (adenine-C2-)-methyltransferase activity
L21SP4_RS08670	COG0517	IMP dehydrogenase activity
L21SP4_RS08670	COG0516	GMP reductase activity
L21SP4_RS08675	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L21SP4_RS08675	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
L21SP4_RS08680	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
L21SP4_RS08695	COG0473	3-isopropylmalate dehydrogenase activity
L21SP4_RS08700	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L21SP4_RS08715	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L21SP4_RS08715	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L21SP4_RS08725	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
L21SP4_RS08730	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L21SP4_RS08730	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L21SP4_RS08750	COG2226	methyltransferase
L21SP4_RS08755	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
L21SP4_RS08765	COG2239	Acts as a magnesium transporter
L21SP4_RS08780	COG0463	Glycosyl transferase, family 2
L21SP4_RS08795	COG1215	transferase activity, transferring glycosyl groups
L21SP4_RS08875	COG0606	chelatase, subunit chli
L21SP4_RS08885	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
L21SP4_RS08890	COG0248	Ppx GppA phosphatase
L21SP4_RS08900	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
L21SP4_RS08905	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
L21SP4_RS08910	COG1785	Belongs to the alkaline phosphatase family
L21SP4_RS08920	COG0047	phosphoribosylformylglycinamidine synthase activity
L21SP4_RS08935	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
L21SP4_RS08950	COG0138	bifunctional purine biosynthesis protein purh
L21SP4_RS08975	COG0673	inositol 2-dehydrogenase activity
L21SP4_RS08995	COG0463	Glycosyl transferase, family 2
L21SP4_RS09000	COG0671	phosphoesterase, PA-phosphatase related
L21SP4_RS09015	COG1872	DUF167
L21SP4_RS09035	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L21SP4_RS09040	COG0525	valine-tRNA ligase activity
L21SP4_RS09045	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L21SP4_RS09065	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
L21SP4_RS09085	COG1027	Aspartate ammonia-lyase
L21SP4_RS09090	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
L21SP4_RS09100	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
L21SP4_RS09110	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
L21SP4_RS09125	COG1141	Ferredoxin
L21SP4_RS09135	COG0731	radical SAM domain protein
L21SP4_RS09135	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
L21SP4_RS09165	COG0823	Involved in the tonB-independent uptake of proteins
L21SP4_RS09170	COG2885	chlorophyll binding
L21SP4_RS09190	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L21SP4_RS09205	COG1136	(ABC) transporter
L21SP4_RS09210	COG0577	efflux transmembrane transporter activity
L21SP4_RS09210	COG1136	(ABC) transporter
L21SP4_RS09230	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
L21SP4_RS09235	COG0668	transmembrane transport
L21SP4_RS09275	COG0310	cobalt ion transport
L21SP4_RS09285	COG0646	methionine synthase
L21SP4_RS09285	COG1410	methionine synthase
L21SP4_RS09290	COG1132	(ABC) transporter
L21SP4_RS09305	COG1122	ATPase activity
L21SP4_RS09310	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
L21SP4_RS09315	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
L21SP4_RS09330	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
L21SP4_RS09350	COG0577	efflux transmembrane transporter activity
L21SP4_RS09350	COG1136	(ABC) transporter
L21SP4_RS09355	COG0501	Belongs to the peptidase M48B family
L21SP4_RS09365	COG2211	Major facilitator Superfamily
L21SP4_RS09380	COG1609	Transcriptional regulator
L21SP4_RS09395	COG0673	inositol 2-dehydrogenase activity
L21SP4_RS09405	COG3119	arylsulfatase activity
L21SP4_RS09415	COG3119	arylsulfatase activity
L21SP4_RS09420	COG3708	Transcriptional regulator
L21SP4_RS09420	COG2207	Transcriptional regulator
L21SP4_RS09455	COG3119	arylsulfatase activity
L21SP4_RS09495	COG0799	negative regulation of ribosome biogenesis
L21SP4_RS09500	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
L21SP4_RS09510	COG0489	protein tyrosine kinase activity
L21SP4_RS09525	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
L21SP4_RS09530	COG0179	Fumarylacetoacetate (FAA) hydrolase
L21SP4_RS09545	COG0574	Belongs to the PEP-utilizing enzyme family
L21SP4_RS09545	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
L21SP4_RS09550	COG2848	UPF0210 protein
L21SP4_RS09565	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
L21SP4_RS09570	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
L21SP4_RS09575	COG0095	Lipoate-protein ligase
L21SP4_RS09590	COG2226	methyltransferase
L21SP4_RS09680	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
L21SP4_RS09685	COG0018	arginyl-trna synthetase
L21SP4_RS09700	COG0517	IMP dehydrogenase activity
L21SP4_RS09705	COG1484	DNA-dependent DNA replication
L21SP4_RS09720	COG0445	tRNA wobble uridine modification
L21SP4_RS09750	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
L21SP4_RS09775	COG1028	Short-chain dehydrogenase reductase Sdr
L21SP4_RS09800	COG1331	Highly conserved protein containing a thioredoxin domain
L21SP4_RS09815	COG1484	DNA-dependent DNA replication
L21SP4_RS09860	COG0673	inositol 2-dehydrogenase activity
L21SP4_RS09870	COG0438	transferase activity, transferring glycosyl groups
L21SP4_RS09875	COG0438	transferase activity, transferring glycosyl groups
L21SP4_RS09880	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
L21SP4_RS09880	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
L21SP4_RS09890	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
L21SP4_RS09895	COG0404	The glycine cleavage system catalyzes the degradation of glycine
L21SP4_RS09900	COG0509	glycine decarboxylation via glycine cleavage system
L21SP4_RS09910	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
L21SP4_RS09920	COG0784	Response regulator, receiver
L21SP4_RS09920	COG2205	protein histidine kinase activity
L21SP4_RS09925	COG0436	Aminotransferase
L21SP4_RS09930	COG1522	sequence-specific DNA binding
L21SP4_RS09935	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
L21SP4_RS09940	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
L21SP4_RS09970	COG1217	gtp-binding protein TYPA
L21SP4_RS09985	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
L21SP4_RS09985	COG0546	phosphoglycolate phosphatase activity
L21SP4_RS10000	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
L21SP4_RS10010	COG0116	Belongs to the methyltransferase superfamily
L21SP4_RS10025	COG1116	anion transmembrane transporter activity
L21SP4_RS10030	COG0390	transport system, permease component
L21SP4_RS10075	COG0489	protein tyrosine kinase activity
L21SP4_RS10080	COG0543	2 iron, 2 sulfur cluster binding
L21SP4_RS10085	COG0167	dihydroorotate dehydrogenase activity
L21SP4_RS10090	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L21SP4_RS10095	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
L21SP4_RS10105	COG1796	DNA polymerase
L21SP4_RS10105	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
L21SP4_RS10130	COG4106	trans-aconitate 2-methyltransferase activity
L21SP4_RS10145	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
L21SP4_RS10155	COG0148	phosphopyruvate hydratase activity
L21SP4_RS10175	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
L21SP4_RS10185	COG1518	maintenance of DNA repeat elements
L21SP4_RS10195	COG1857	crispr-associated protein
L21SP4_RS10210	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
L21SP4_RS10225	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L21SP4_RS10230	COG0154	amidase activity
L21SP4_RS10240	COG2195	Cleaves the N-terminal amino acid of tripeptides
L21SP4_RS10260	COG1187	pseudouridine synthase activity
L21SP4_RS10280	COG3425	synthase
L21SP4_RS10295	COG5002	protein histidine kinase activity
L21SP4_RS10300	COG3852	Histidine kinase
L21SP4_RS10305	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L21SP4_RS10315	COG5002	protein histidine kinase activity
L21SP4_RS10325	COG1196	nuclear chromosome segregation
L21SP4_RS10330	COG0542	response to heat
L21SP4_RS10335	COG3869	Catalyzes the specific phosphorylation of arginine residues in
L21SP4_RS10340	COG0542	response to heat
L21SP4_RS10345	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L21SP4_RS10350	COG1136	(ABC) transporter
L21SP4_RS10360	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
L21SP4_RS10375	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
L21SP4_RS10390	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
L21SP4_RS10405	COG0037	tRNA processing
L21SP4_RS10410	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L21SP4_RS10415	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
L21SP4_RS10420	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
L21SP4_RS10440	COG0438	transferase activity, transferring glycosyl groups
L21SP4_RS10450	COG3250	beta-galactosidase activity
L21SP4_RS10455	COG0281	malic enzyme
L21SP4_RS10455	COG0280	phosphate acetyltransferase
L21SP4_RS10475	COG1414	Transcriptional regulator
L21SP4_RS10485	COG3344	reverse transcriptase
L21SP4_RS10520	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
L21SP4_RS10520	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
L21SP4_RS10525	COG0105	UTP biosynthetic process
L21SP4_RS10530	COG1448	Aminotransferase
L21SP4_RS10535	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
L21SP4_RS10555	COG1192	Involved in chromosome partitioning
L21SP4_RS10565	COG4176	ABC-type proline glycine betaine transport system permease component
L21SP4_RS10600	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
L21SP4_RS10610	COG4608	Belongs to the ABC transporter superfamily
L21SP4_RS10625	COG2738	Putative neutral zinc metallopeptidase
L21SP4_RS10635	COG3254	rhamnose metabolic process
L21SP4_RS10665	COG0484	heat shock protein binding
L21SP4_RS10670	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
L21SP4_RS10685	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
L21SP4_RS10695	COG0424	maF-like protein
L21SP4_RS10700	COG1940	carbohydrate kinase activity
L21SP4_RS10710	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
L21SP4_RS10715	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
L21SP4_RS10720	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
L21SP4_RS10765	COG3119	arylsulfatase activity
L21SP4_RS10780	COG3119	arylsulfatase activity
L21SP4_RS10785	COG3250	beta-galactosidase activity
L21SP4_RS10795	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L21SP4_RS10855	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
L21SP4_RS10860	COG2226	methyltransferase
L21SP4_RS10875	COG0495	leucyl-tRNA aminoacylation
L21SP4_RS10885	COG0537	adenosine 5'-monophosphoramidase activity
L21SP4_RS10925	COG2267	carboxylic ester hydrolase activity
L21SP4_RS10925	COG2226	methyltransferase
L21SP4_RS10930	COG0156	8-amino-7-oxononanoate synthase activity
L21SP4_RS10935	COG0134	indole-3-glycerol-phosphate synthase activity
L21SP4_RS10940	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
L21SP4_RS10955	COG0848	biopolymer transport protein
L21SP4_RS10965	COG0811	peptide transport
L21SP4_RS10970	COG0811	peptide transport
L21SP4_RS11005	COG1469	GTP cyclohydrolase I activity
L21SP4_RS11020	COG3940	Belongs to the glycosyl hydrolase 43 family
L21SP4_RS11050	COG5632	N-Acetylmuramoyl-L-alanine amidase
L21SP4_RS11050	COG3409	Peptidoglycan-binding domain 1 protein
L21SP4_RS11055	COG0616	signal peptide processing
L21SP4_RS11055	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
L21SP4_RS11060	COG0114	fumarate hydratase activity
L21SP4_RS11070	COG1028	Short-chain dehydrogenase reductase Sdr
L21SP4_RS11075	COG0277	FAD linked oxidase domain protein
L21SP4_RS11090	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L21SP4_RS11105	COG1482	cell wall glycoprotein biosynthetic process
L21SP4_RS11110	COG1732	Glycine betaine
L21SP4_RS11125	COG1011	Hydrolase
L21SP4_RS11135	COG1216	Glycosyl transferase, family 2
L21SP4_RS11140	COG0438	transferase activity, transferring glycosyl groups
L21SP4_RS11175	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
L21SP4_RS11190	COG1088	dTDP-glucose 4,6-dehydratase activity
L21SP4_RS11250	COG0673	inositol 2-dehydrogenase activity
L21SP4_RS11290	COG0367	asparagine synthase
L21SP4_RS11295	COG2244	polysaccharide biosynthetic process
L21SP4_RS11320	COG3344	reverse transcriptase
L21SP4_RS11345	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
L21SP4_RS11350	COG2046	Belongs to the sulfate adenylyltransferase family
L21SP4_RS11350	COG0529	Catalyzes the synthesis of activated sulfate
L21SP4_RS11355	COG3273	potassium ion transport
L21SP4_RS11355	COG0471	metal ion transport
L21SP4_RS11360	COG1218	3'(2'),5'-bisphosphate nucleotidase
L21SP4_RS11370	COG1510	regulation of RNA biosynthetic process
L21SP4_RS11385	COG1659	Linocin_M18 bacteriocin protein
L21SP4_RS11390	COG0210	DNA helicase
L21SP4_RS11420	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
L21SP4_RS11425	COG0497	DNA recombination
L21SP4_RS11430	COG2207	Transcriptional regulator
L21SP4_RS11455	COG0811	peptide transport
L21SP4_RS11465	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
L21SP4_RS11475	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
L21SP4_RS11485	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
L21SP4_RS11490	COG0235	Class ii aldolase
L21SP4_RS11510	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
L21SP4_RS11530	COG1131	(ABC) transporter
L21SP4_RS11540	COG1074	ATP-dependent DNA helicase activity
L21SP4_RS11550	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
L21SP4_RS11555	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
L21SP4_RS11560	COG0575	Belongs to the CDS family
L21SP4_RS11565	COG0750	zinc metalloprotease
L21SP4_RS11575	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
L21SP4_RS11635	COG3119	arylsulfatase activity
L21SP4_RS11635	COG3408	Glycogen debranching enzyme
L21SP4_RS11655	COG2826	transposase and inactivated derivatives, IS30 family
L21SP4_RS11665	COG0446	pyridine nucleotide-disulphide oxidoreductase
L21SP4_RS11735	COG2801	Transposase and inactivated derivatives
L21SP4_RS11795	COG3550	peptidyl-serine autophosphorylation
L21SP4_RS11815	COG3119	arylsulfatase activity
L21SP4_RS11845	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
L21SP4_RS11850	COG1028	Short-chain dehydrogenase reductase Sdr
L21SP4_RS11865	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
L21SP4_RS11875	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
L21SP4_RS11885	COG2255	four-way junction helicase activity
L21SP4_RS11890	COG0632	four-way junction helicase activity
L21SP4_RS11900	COG2759	Belongs to the formate--tetrahydrofolate ligase family
L21SP4_RS11910	COG2207	Transcriptional regulator
L21SP4_RS11935	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
L21SP4_RS11940	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
L21SP4_RS11945	COG2086	electron transfer activity
L21SP4_RS11950	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
L21SP4_RS11955	COG1686	Belongs to the peptidase S11 family
L21SP4_RS11990	COG3119	arylsulfatase activity
L21SP4_RS12000	COG4977	sequence-specific DNA binding
L21SP4_RS12000	COG1917	Cupin 2, conserved barrel domain protein
L21SP4_RS12015	COG0366	Alpha amylase catalytic
L21SP4_RS12020	COG2207	Transcriptional regulator
L21SP4_RS12020	COG1609	Transcriptional regulator
L21SP4_RS12035	COG2801	Transposase and inactivated derivatives
L21SP4_RS12045	COG3344	reverse transcriptase
L21SP4_RS12050	COG3119	arylsulfatase activity
L21SP4_RS12080	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
L21SP4_RS12085	COG1418	mRNA catabolic process
L21SP4_RS12090	COG4536	flavin adenine dinucleotide binding
L21SP4_RS12095	COG1253	flavin adenine dinucleotide binding
L21SP4_RS12115	COG0022	dehydrogenase e1 component
L21SP4_RS12135	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
L21SP4_RS12140	COG1454	alcohol dehydrogenase
L21SP4_RS12140	COG1012	belongs to the aldehyde dehydrogenase family
L21SP4_RS12160	COG1131	(ABC) transporter
L21SP4_RS12165	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
L21SP4_RS12170	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
L21SP4_RS12170	COG3170	Tfp pilus assembly protein FimV