locus-tag	class	description
EGM51_RS00010	COG0438	transferase activity, transferring glycosyl groups
EGM51_RS00020	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EGM51_RS00025	COG3119	arylsulfatase activity
EGM51_RS00045	COG3547	Transposase (IS116 IS110 IS902 family)
EGM51_RS00080	COG1028	Short-chain dehydrogenase reductase Sdr
EGM51_RS00090	COG3119	arylsulfatase activity
EGM51_RS00095	COG2814	Major facilitator Superfamily
EGM51_RS00110	COG1012	belongs to the aldehyde dehydrogenase family
EGM51_RS00195	COG4585	Histidine kinase
EGM51_RS00220	COG4585	Histidine kinase
EGM51_RS00225	COG4585	Histidine kinase
EGM51_RS00230	COG2197	response regulator
EGM51_RS00245	COG3119	arylsulfatase activity
EGM51_RS00270	COG3250	beta-galactosidase activity
EGM51_RS00280	COG1012	belongs to the aldehyde dehydrogenase family
EGM51_RS00285	COG4948	Mandelate Racemase Muconate Lactonizing
EGM51_RS00290	COG1063	alcohol dehydrogenase
EGM51_RS00295	COG1028	Short-chain dehydrogenase reductase Sdr
EGM51_RS00300	COG1609	Transcriptional regulator
EGM51_RS00300	COG2207	Transcriptional regulator
EGM51_RS00315	COG3119	arylsulfatase activity
EGM51_RS00320	COG3250	beta-galactosidase activity
EGM51_RS00330	COG2814	Major facilitator Superfamily
EGM51_RS00370	COG3119	arylsulfatase activity
EGM51_RS00375	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EGM51_RS00380	COG0826	peptidase U32
EGM51_RS00450	COG1442	glycosyl transferase family 8
EGM51_RS00450	COG1216	Glycosyl transferase, family 2
EGM51_RS00470	COG0438	transferase activity, transferring glycosyl groups
EGM51_RS00485	COG0438	transferase activity, transferring glycosyl groups
EGM51_RS00495	COG0438	transferase activity, transferring glycosyl groups
EGM51_RS00500	COG0438	transferase activity, transferring glycosyl groups
EGM51_RS00520	COG0110	maltose O-acetyltransferase activity
EGM51_RS00525	COG0463	Glycosyl transferase, family 2
EGM51_RS00570	COG0579	oxidoreductase
EGM51_RS00580	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
EGM51_RS00585	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
EGM51_RS00595	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EGM51_RS00640	COG1151	hydroxylamine reductase activity
EGM51_RS00650	COG2501	S4 domain
EGM51_RS00715	COG0714	Associated with various cellular activities
EGM51_RS00720	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EGM51_RS00745	COG4372	Transposase
EGM51_RS00760	COG3119	arylsulfatase activity
EGM51_RS00795	COG2066	Belongs to the glutaminase family
EGM51_RS00850	COG1136	(ABC) transporter
EGM51_RS00930	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EGM51_RS00935	COG0358	DNA primase activity
EGM51_RS01040	COG1937	Protein conserved in bacteria
EGM51_RS01045	COG1230	cation diffusion facilitator family transporter
EGM51_RS01125	COG4412	M6 family metalloprotease domain protein
EGM51_RS01125	COG1404	Belongs to the peptidase S8 family
EGM51_RS01210	COG1937	Protein conserved in bacteria
EGM51_RS01215	COG5002	protein histidine kinase activity
EGM51_RS01220	COG2204	response regulator
EGM51_RS01225	COG2204	response regulator
EGM51_RS01255	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EGM51_RS01305	COG3411	Ferredoxin
EGM51_RS01310	COG4585	Histidine kinase
EGM51_RS01325	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EGM51_RS01425	COG3584	3D domain protein
EGM51_RS01440	COG2755	lipolytic protein G-D-S-L family
EGM51_RS01440	COG0657	acetylesterase activity
EGM51_RS01535	COG1234	tRNA 3'-trailer cleavage
EGM51_RS01545	COG0706	membrane insertase activity
EGM51_RS01550	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
EGM51_RS01555	COG0594	ribonuclease P activity
EGM51_RS01560	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EGM51_RS01565	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EGM51_RS01590	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EGM51_RS01595	COG1324	tolerance protein
EGM51_RS01625	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EGM51_RS01635	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EGM51_RS01645	COG1131	(ABC) transporter
EGM51_RS01670	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
EGM51_RS01675	COG2768	binding domain, Protein
EGM51_RS01705	COG3119	arylsulfatase activity
EGM51_RS01715	COG3119	arylsulfatase activity
EGM51_RS01720	COG3119	arylsulfatase activity
EGM51_RS01735	COG3250	beta-galactosidase activity
EGM51_RS01740	COG0142	geranyltranstransferase activity
EGM51_RS01775	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EGM51_RS01780	COG1121	(ABC) transporter
EGM51_RS01785	COG3443	Belongs to the bacterial solute-binding protein 9 family
EGM51_RS01785	COG0803	Belongs to the bacterial solute-binding protein 9 family
EGM51_RS01790	COG1872	DUF167
EGM51_RS01825	COG1518	maintenance of DNA repeat elements
EGM51_RS01830	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
EGM51_RS01835	COG1181	Belongs to the D-alanine--D-alanine ligase family
EGM51_RS01840	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EGM51_RS01845	COG0849	cell division
EGM51_RS01860	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EGM51_RS01890	COG2195	Cleaves the N-terminal amino acid of tripeptides
EGM51_RS01895	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EGM51_RS01910	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EGM51_RS01915	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EGM51_RS01920	COG1450	Type ii and iii secretion system protein
EGM51_RS01940	COG4191	Histidine kinase
EGM51_RS01955	COG0673	inositol 2-dehydrogenase activity
EGM51_RS01960	COG1482	cell wall glycoprotein biosynthetic process
EGM51_RS01965	COG3250	beta-galactosidase activity
EGM51_RS01970	COG1968	undecaprenyl-diphosphatase activity
EGM51_RS01975	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EGM51_RS01975	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EGM51_RS01980	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EGM51_RS01985	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EGM51_RS02000	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EGM51_RS02000	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EGM51_RS02005	COG0307	riboflavin synthase, alpha
EGM51_RS02015	COG2861	carbohydrate metabolic process
EGM51_RS02020	COG0300	oxidoreductase activity
EGM51_RS02035	COG0432	Pfam Uncharacterised protein family UPF0047
EGM51_RS02040	COG4536	flavin adenine dinucleotide binding
EGM51_RS02060	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
EGM51_RS02070	COG0674	pyruvate-flavodoxin oxidoreductase activity
EGM51_RS02070	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EGM51_RS02090	COG0275	rRNA processing
EGM51_RS02100	COG0768	penicillin binding
EGM51_RS02110	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EGM51_RS02115	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EGM51_RS02120	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EGM51_RS02130	COG0772	Belongs to the SEDS family
EGM51_RS02135	COG0116	Belongs to the methyltransferase superfamily
EGM51_RS02135	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EGM51_RS02140	COG0564	pseudouridine synthase activity
EGM51_RS02145	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EGM51_RS02150	COG0778	Nitroreductase
EGM51_RS02155	COG3118	belongs to the thioredoxin family
EGM51_RS02195	COG0343	queuine tRNA-ribosyltransferase activity
EGM51_RS02205	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EGM51_RS02205	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EGM51_RS02210	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EGM51_RS02225	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EGM51_RS02230	COG1366	Belongs to the anti-sigma-factor antagonist family
EGM51_RS02240	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
EGM51_RS02240	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EGM51_RS02245	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EGM51_RS02255	COG5002	protein histidine kinase activity
EGM51_RS02270	COG0750	zinc metalloprotease
EGM51_RS02275	COG4589	Belongs to the CDS family
EGM51_RS02285	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EGM51_RS02295	COG0196	riboflavin kinase activity
EGM51_RS02300	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EGM51_RS02305	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EGM51_RS02330	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
EGM51_RS02340	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EGM51_RS02380	COG0509	glycine decarboxylation via glycine cleavage system
EGM51_RS02385	COG0321	lipoyl(octanoyl) transferase activity
EGM51_RS02390	COG0321	lipoyl(octanoyl) transferase activity
EGM51_RS02400	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
EGM51_RS02405	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EGM51_RS02410	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EGM51_RS02420	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EGM51_RS02425	COG0641	radical SAM
EGM51_RS02430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EGM51_RS02435	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EGM51_RS02440	COG0805	protein transport
EGM51_RS02445	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EGM51_RS02470	COG0527	aspartate kinase activity
EGM51_RS02475	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
EGM51_RS02480	COG0300	oxidoreductase activity
EGM51_RS02490	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EGM51_RS02500	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EGM51_RS02520	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EGM51_RS02525	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EGM51_RS02535	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EGM51_RS02540	COG0540	Belongs to the ATCase OTCase family
EGM51_RS02545	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EGM51_RS02550	COG0859	PFAM glycosyl transferase family 9
EGM51_RS02570	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EGM51_RS02575	COG0720	synthase
EGM51_RS02580	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EGM51_RS02595	COG3119	arylsulfatase activity
EGM51_RS02605	COG2096	Adenosyltransferase
EGM51_RS02615	COG3239	Fatty acid desaturase
EGM51_RS02620	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EGM51_RS02625	COG0228	four-way junction DNA binding
EGM51_RS02630	COG1837	Belongs to the UPF0109 family
EGM51_RS02640	COG0335	large ribosomal subunit rRNA binding
EGM51_RS02645	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EGM51_RS02650	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EGM51_RS02660	COG1702	phosphate starvation-inducible protein PhoH
EGM51_RS02670	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EGM51_RS02670	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EGM51_RS02670	COG0674	pyruvate-flavodoxin oxidoreductase activity
EGM51_RS02670	COG1013	pyruvate-flavodoxin oxidoreductase activity
EGM51_RS02695	COG2207	Transcriptional regulator
EGM51_RS02695	COG1609	Transcriptional regulator
EGM51_RS02705	COG0800	Aldolase
EGM51_RS02710	COG3132	Protein of unknown function, DUF480
EGM51_RS02715	COG3119	arylsulfatase activity
EGM51_RS02725	COG2239	Acts as a magnesium transporter
EGM51_RS02730	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
EGM51_RS02750	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
EGM51_RS02750	COG1605	Chorismate mutase
EGM51_RS02775	COG0351	phosphomethylpyrimidine kinase
EGM51_RS02780	COG2816	NAD+ diphosphatase activity
EGM51_RS02840	COG4968	Prepilin-type N-terminal cleavage methylation domain
EGM51_RS02845	COG0151	Belongs to the GarS family
EGM51_RS02855	COG3858	chitin binding
EGM51_RS02910	COG4191	Histidine kinase
EGM51_RS02980	COG0508	dehydrogenase complex catalyzes the overall conversion of
EGM51_RS02990	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EGM51_RS02995	COG1242	4 iron, 4 sulfur cluster binding
EGM51_RS03000	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EGM51_RS03005	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
EGM51_RS03040	COG5012	cobalamin binding
EGM51_RS03045	COG2759	Belongs to the formate--tetrahydrofolate ligase family
EGM51_RS03050	COG2116	formate transmembrane transporter activity
EGM51_RS03060	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EGM51_RS03065	COG2207	Transcriptional regulator
EGM51_RS03065	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EGM51_RS03075	COG0859	PFAM glycosyl transferase family 9
EGM51_RS03085	COG0668	transmembrane transport
EGM51_RS03095	COG2226	methyltransferase
EGM51_RS03100	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EGM51_RS03105	COG4628	conserved protein (DUF2132)
EGM51_RS03120	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EGM51_RS03130	COG4977	sequence-specific DNA binding
EGM51_RS03155	COG1757	Na H antiporter
EGM51_RS03200	COG3119	arylsulfatase activity
EGM51_RS03225	COG5434	Belongs to the glycosyl hydrolase 28 family
EGM51_RS03235	COG3119	arylsulfatase activity
EGM51_RS03245	COG2207	Transcriptional regulator
EGM51_RS03245	COG1609	Transcriptional regulator
EGM51_RS03250	COG0246	Mannitol dehydrogenase
EGM51_RS03260	COG3250	beta-galactosidase activity
EGM51_RS03275	COG3119	arylsulfatase activity
EGM51_RS03280	COG3408	Glycogen debranching enzyme
EGM51_RS03280	COG3119	arylsulfatase activity
EGM51_RS03290	COG3408	Glycogen debranching enzyme
EGM51_RS03290	COG3119	arylsulfatase activity
EGM51_RS03295	COG3119	arylsulfatase activity
EGM51_RS03295	COG3408	Glycogen debranching enzyme
EGM51_RS03330	COG1196	nuclear chromosome segregation
EGM51_RS03335	COG1196	nuclear chromosome segregation
EGM51_RS03345	COG3852	Histidine kinase
EGM51_RS03350	COG0471	metal ion transport
EGM51_RS03365	COG0124	histidyl-tRNA synthetase
EGM51_RS03370	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EGM51_RS03410	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EGM51_RS03415	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EGM51_RS03435	COG0546	phosphoglycolate phosphatase activity
EGM51_RS03450	COG0237	dephospho-CoA kinase activity
EGM51_RS03475	COG1028	Short-chain dehydrogenase reductase Sdr
EGM51_RS03480	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EGM51_RS03485	COG0825	malonyl-CoA metabolic process
EGM51_RS03490	COG0791	NLP P60 protein
EGM51_RS03490	COG1388	LysM domain
EGM51_RS03505	COG0497	DNA recombination
EGM51_RS03515	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EGM51_RS03525	COG0513	Belongs to the DEAD box helicase family
EGM51_RS03535	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EGM51_RS03540	COG0416	fatty acid biosynthetic process
EGM51_RS03550	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EGM51_RS03555	COG1028	Short-chain dehydrogenase reductase Sdr
EGM51_RS03560	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EGM51_RS03565	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EGM51_RS03570	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
EGM51_RS03570	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EGM51_RS03600	COG0848	biopolymer transport protein
EGM51_RS03605	COG0848	biopolymer transport protein
EGM51_RS03635	COG1560	Kdo2-lipid A biosynthetic process
EGM51_RS03645	COG4657	Part of a membrane complex involved in electron transport
EGM51_RS03650	COG2878	Part of a membrane complex involved in electron transport
EGM51_RS03655	COG4656	Part of a membrane complex involved in electron transport
EGM51_RS03660	COG4658	electron transport chain
EGM51_RS03670	COG4659	FMN binding
EGM51_RS03675	COG4660	Part of a membrane complex involved in electron transport
EGM51_RS03755	COG1747	RNA polymerase binding
EGM51_RS03755	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EGM51_RS03760	COG0457	Tetratricopeptide repeat
EGM51_RS03760	COG0515	serine threonine protein kinase
EGM51_RS03765	COG0408	coproporphyrinogen oxidase activity
EGM51_RS03770	COG0668	transmembrane transport
EGM51_RS03780	COG0166	Belongs to the GPI family
EGM51_RS03810	COG1959	2 iron, 2 sulfur cluster binding
EGM51_RS03815	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EGM51_RS03845	COG2273	Hydrolase Family 16
EGM51_RS03855	COG3119	arylsulfatase activity
EGM51_RS03855	COG3408	Glycogen debranching enzyme
EGM51_RS03880	COG0436	Aminotransferase
EGM51_RS03885	COG1519	Transferase
EGM51_RS03895	COG0517	IMP dehydrogenase activity
EGM51_RS03895	COG1994	Peptidase M50
EGM51_RS03900	COG0640	Transcriptional regulator
EGM51_RS03905	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
EGM51_RS03910	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EGM51_RS03915	COG0530	calcium, potassium:sodium antiporter activity
EGM51_RS03935	COG1363	Peptidase, m42
EGM51_RS03955	COG0438	transferase activity, transferring glycosyl groups
EGM51_RS03980	COG1132	(ABC) transporter
EGM51_RS03995	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EGM51_RS04000	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EGM51_RS04005	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EGM51_RS04095	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EGM51_RS04100	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EGM51_RS04105	COG0442	prolyl-tRNA aminoacylation
EGM51_RS04135	COG3408	Glycogen debranching enzyme
EGM51_RS04135	COG3119	arylsulfatase activity
EGM51_RS04145	COG3119	arylsulfatase activity
EGM51_RS04160	COG3119	arylsulfatase activity
EGM51_RS04185	COG3250	beta-galactosidase activity
EGM51_RS04230	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EGM51_RS04235	COG0066	3-isopropylmalate dehydratase activity
EGM51_RS04240	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EGM51_RS04250	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EGM51_RS04255	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EGM51_RS04260	COG0037	tRNA processing
EGM51_RS04265	COG0728	peptidoglycan biosynthetic process
EGM51_RS04305	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EGM51_RS04320	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EGM51_RS04330	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
EGM51_RS04340	COG5434	Belongs to the glycosyl hydrolase 28 family
EGM51_RS04350	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EGM51_RS04370	COG1104	cysteine desulfurase activity
EGM51_RS04375	COG0301	tRNA thio-modification
EGM51_RS04380	COG1752	Esterase of the alpha-beta hydrolase superfamily
EGM51_RS04390	COG1105	Belongs to the carbohydrate kinase PfkB family
EGM51_RS04405	COG0318	PFAM AMP-dependent synthetase and ligase
EGM51_RS04420	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EGM51_RS04425	COG0052	Belongs to the universal ribosomal protein uS2 family
EGM51_RS04430	COG1331	Highly conserved protein containing a thioredoxin domain
EGM51_RS04455	COG1459	type II secretion system
EGM51_RS04485	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EGM51_RS04545	COG4372	Transposase
EGM51_RS04570	COG3119	arylsulfatase activity
EGM51_RS04580	COG3119	arylsulfatase activity
EGM51_RS04585	COG3119	arylsulfatase activity
EGM51_RS04590	COG4585	Histidine kinase
EGM51_RS04595	COG2197	response regulator
EGM51_RS04635	COG0673	inositol 2-dehydrogenase activity
EGM51_RS04670	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EGM51_RS04680	COG3119	arylsulfatase activity
EGM51_RS04685	COG2169	Transcriptional regulator
EGM51_RS04710	COG1609	Transcriptional regulator
EGM51_RS04740	COG3850	Histidine kinase
EGM51_RS04745	COG2197	response regulator
EGM51_RS04760	COG3119	arylsulfatase activity
EGM51_RS04770	COG3119	arylsulfatase activity
EGM51_RS04775	COG3401	FG-GAP repeat protein
EGM51_RS04810	COG3119	arylsulfatase activity
EGM51_RS04820	COG3401	FG-GAP repeat protein
EGM51_RS04840	COG2211	Major facilitator Superfamily
EGM51_RS04855	COG0673	inositol 2-dehydrogenase activity
EGM51_RS04865	COG4585	Histidine kinase
EGM51_RS04870	COG2197	response regulator
EGM51_RS04875	COG0673	inositol 2-dehydrogenase activity
EGM51_RS04890	COG3401	FG-GAP repeat protein
EGM51_RS04910	COG3119	arylsulfatase activity
EGM51_RS04920	COG0445	tRNA wobble uridine modification
EGM51_RS04930	COG3119	arylsulfatase activity
EGM51_RS04945	COG3119	arylsulfatase activity
EGM51_RS04950	COG3119	arylsulfatase activity
EGM51_RS04975	COG3250	beta-galactosidase activity
EGM51_RS05015	COG0395	ABC-type sugar transport system, permease component
EGM51_RS05025	COG1175	transmembrane transport
EGM51_RS05030	COG3842	ATPase activity
EGM51_RS05035	COG4977	sequence-specific DNA binding
EGM51_RS05035	COG1917	Cupin 2, conserved barrel domain protein
EGM51_RS05040	COG3119	arylsulfatase activity
EGM51_RS05060	COG1874	Beta-galactosidase
EGM51_RS05065	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EGM51_RS05070	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EGM51_RS05075	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EGM51_RS05080	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EGM51_RS05100	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EGM51_RS05105	COG1136	(ABC) transporter
EGM51_RS05120	COG3869	Catalyzes the specific phosphorylation of arginine residues in
EGM51_RS05125	COG0542	response to heat
EGM51_RS05140	COG0018	arginyl-trna synthetase
EGM51_RS05170	COG0251	oxidation-reduction process
EGM51_RS05175	COG1477	protein flavinylation
EGM51_RS05185	COG0058	SHG alpha-glucan phosphorylase activity
EGM51_RS05190	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EGM51_RS05250	COG3119	arylsulfatase activity
EGM51_RS05265	COG0673	inositol 2-dehydrogenase activity
EGM51_RS05275	COG3119	arylsulfatase activity
EGM51_RS05295	COG2197	response regulator
EGM51_RS05300	COG3119	arylsulfatase activity
EGM51_RS05305	COG3408	Glycogen debranching enzyme
EGM51_RS05305	COG3119	arylsulfatase activity
EGM51_RS05305	COG3408	Glycogen debranching enzyme
EGM51_RS05305	COG3119	arylsulfatase activity
EGM51_RS05310	COG3119	arylsulfatase activity
EGM51_RS05310	COG3408	Glycogen debranching enzyme
EGM51_RS05340	COG2197	response regulator
EGM51_RS05345	COG4585	Histidine kinase
EGM51_RS05360	COG2197	response regulator
EGM51_RS05365	COG4585	Histidine kinase
EGM51_RS05425	COG4447	cellulose binding
EGM51_RS05430	COG3119	arylsulfatase activity
EGM51_RS05450	COG3119	arylsulfatase activity
EGM51_RS05455	COG0673	inositol 2-dehydrogenase activity
EGM51_RS05485	COG3119	arylsulfatase activity
EGM51_RS05485	COG3408	Glycogen debranching enzyme
EGM51_RS05490	COG3119	arylsulfatase activity
EGM51_RS05555	COG1472	Belongs to the glycosyl hydrolase 3 family
EGM51_RS05560	COG2207	Transcriptional regulator
EGM51_RS05560	COG4753	response regulator
EGM51_RS05570	COG3250	beta-galactosidase activity
EGM51_RS05575	COG3119	arylsulfatase activity
EGM51_RS05600	COG0494	nUDIX hydrolase
EGM51_RS05605	COG0232	Belongs to the dGTPase family. Type 2 subfamily
EGM51_RS05620	COG0482	sulfurtransferase activity
EGM51_RS05635	COG1187	pseudouridine synthase activity
EGM51_RS05650	COG1917	Cupin 2, conserved barrel domain protein
EGM51_RS05655	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EGM51_RS05665	COG1846	Transcriptional regulator
EGM51_RS05680	COG1254	Belongs to the acylphosphatase family
EGM51_RS05690	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EGM51_RS05700	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
EGM51_RS05710	COG0047	phosphoribosylformylglycinamidine synthase activity
EGM51_RS05715	COG0284	orotidine-5'-phosphate decarboxylase activity
EGM51_RS05720	COG0366	Alpha amylase catalytic
EGM51_RS05725	COG0438	transferase activity, transferring glycosyl groups
EGM51_RS05735	COG1215	transferase activity, transferring glycosyl groups
EGM51_RS05745	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EGM51_RS05745	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EGM51_RS05755	COG1216	Glycosyl transferase, family 2
EGM51_RS05760	COG2308	Evidence 4 Homologs of previously reported genes of
EGM51_RS05800	COG1368	sulfuric ester hydrolase activity
EGM51_RS05805	COG1643	Atp-dependent helicase
EGM51_RS05810	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EGM51_RS05815	COG0517	IMP dehydrogenase activity
EGM51_RS05815	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
EGM51_RS05825	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EGM51_RS05840	COG0328	RNA-DNA hybrid ribonuclease activity
EGM51_RS05860	COG0514	ATP-dependent DNA helicase (RecQ)
EGM51_RS05875	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EGM51_RS05880	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EGM51_RS05885	COG0287	Prephenate dehydrogenase
EGM51_RS05890	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EGM51_RS05895	COG3119	arylsulfatase activity
EGM51_RS05905	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
EGM51_RS05920	COG0423	glycine-tRNA ligase activity
EGM51_RS05935	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EGM51_RS05955	COG1127	ABC transporter
EGM51_RS05960	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EGM51_RS05975	COG0489	protein tyrosine kinase activity
EGM51_RS05980	COG2151	metal-sulfur cluster biosynthetic enzyme
EGM51_RS05990	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EGM51_RS05995	COG0719	Fe-S assembly protein
EGM51_RS06000	COG0396	ATPase activity
EGM51_RS06005	COG0719	Fe-S assembly protein
EGM51_RS06015	COG3956	TIGRFAM MazG family protein
EGM51_RS06025	COG0505	Belongs to the CarA family
EGM51_RS06030	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EGM51_RS06030	COG0519	Catalyzes the synthesis of GMP from XMP
EGM51_RS06035	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EGM51_RS06045	COG1663	tetraacyldisaccharide 4'-kinase activity
EGM51_RS06055	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EGM51_RS06065	COG1691	(AIR) carboxylase
EGM51_RS06070	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EGM51_RS06075	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EGM51_RS06080	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EGM51_RS06090	COG3119	arylsulfatase activity
EGM51_RS06095	COG3119	arylsulfatase activity
EGM51_RS06100	COG1917	Cupin 2, conserved barrel domain protein
EGM51_RS06100	COG2207	Transcriptional regulator
EGM51_RS06115	COG4948	Mandelate Racemase Muconate Lactonizing
EGM51_RS06120	COG1012	belongs to the aldehyde dehydrogenase family
EGM51_RS06125	COG0800	Aldolase
EGM51_RS06155	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EGM51_RS06165	COG3250	beta-galactosidase activity
EGM51_RS06170	COG3119	arylsulfatase activity
EGM51_RS06175	COG3119	arylsulfatase activity
EGM51_RS06205	COG2169	Transcriptional regulator
EGM51_RS06205	COG1917	Cupin 2, conserved barrel domain protein
EGM51_RS06210	COG3250	beta-galactosidase activity
EGM51_RS06230	COG1312	Catalyzes the dehydration of D-mannonate
EGM51_RS06265	COG3401	FG-GAP repeat protein
EGM51_RS06270	COG3401	FG-GAP repeat protein
EGM51_RS06300	COG2211	Major facilitator Superfamily
EGM51_RS06305	COG3250	beta-galactosidase activity
EGM51_RS06315	COG1609	Transcriptional regulator
EGM51_RS06320	COG0708	Exodeoxyribonuclease III
EGM51_RS06325	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EGM51_RS06330	COG1509	lysine 2,3-aminomutase activity
EGM51_RS06340	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EGM51_RS06345	COG1805	sodium ion transport
EGM51_RS06350	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EGM51_RS06355	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EGM51_RS06360	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EGM51_RS06375	COG0659	secondary active sulfate transmembrane transporter activity
EGM51_RS06380	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EGM51_RS06385	COG2234	aminopeptidase activity
EGM51_RS06400	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
EGM51_RS06405	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
EGM51_RS06430	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EGM51_RS06435	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EGM51_RS06440	COG3119	arylsulfatase activity
EGM51_RS06445	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EGM51_RS06450	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EGM51_RS06465	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EGM51_RS06505	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
EGM51_RS06520	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EGM51_RS06525	COG0205	6-phosphofructokinase activity
EGM51_RS06530	COG0737	Belongs to the 5'-nucleotidase family
EGM51_RS06535	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EGM51_RS06560	COG0528	UMP kinase activity
EGM51_RS06565	COG0233	cytoplasmic translational termination
EGM51_RS06570	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EGM51_RS06590	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EGM51_RS06615	COG0297	glycogen (starch) synthase activity
EGM51_RS06620	COG0557	exoribonuclease II activity
EGM51_RS06640	COG1192	Involved in chromosome partitioning
EGM51_RS06650	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EGM51_RS06660	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EGM51_RS06675	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
EGM51_RS06685	COG1136	(ABC) transporter
EGM51_RS06685	COG0577	efflux transmembrane transporter activity
EGM51_RS06690	COG1136	(ABC) transporter
EGM51_RS06690	COG0577	efflux transmembrane transporter activity
EGM51_RS06710	COG0590	tRNA wobble adenosine to inosine editing
EGM51_RS06715	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EGM51_RS06725	COG1132	(ABC) transporter
EGM51_RS06730	COG1132	(ABC) transporter
EGM51_RS06735	COG1028	Short-chain dehydrogenase reductase Sdr
EGM51_RS06740	COG0277	FAD linked oxidase domain protein
EGM51_RS06755	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EGM51_RS06760	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EGM51_RS06765	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EGM51_RS06775	COG1027	Aspartate ammonia-lyase
EGM51_RS06810	COG3119	arylsulfatase activity
EGM51_RS06830	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
EGM51_RS06835	COG1609	Transcriptional regulator
EGM51_RS06840	COG1609	Transcriptional regulator
EGM51_RS06855	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EGM51_RS06885	COG2877	3-deoxy-8-phosphooctulonate synthase activity
EGM51_RS06890	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
EGM51_RS06895	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EGM51_RS06900	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
EGM51_RS06905	COG0116	Belongs to the methyltransferase superfamily
EGM51_RS06945	COG4372	Transposase
EGM51_RS06960	COG0516	GMP reductase activity
EGM51_RS06960	COG0517	IMP dehydrogenase activity
EGM51_RS06965	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EGM51_RS06965	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EGM51_RS06980	COG0512	Glutamine amidotransferase of anthranilate synthase
EGM51_RS07000	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EGM51_RS07005	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EGM51_RS07015	COG0107	imidazoleglycerol-phosphate synthase activity
EGM51_RS07020	COG0557	exoribonuclease II activity
EGM51_RS07025	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
EGM51_RS07030	COG2003	Belongs to the UPF0758 family
EGM51_RS07035	COG0756	dUTP diphosphatase activity
EGM51_RS07040	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EGM51_RS07045	COG0733	neurotransmitter:sodium symporter activity
EGM51_RS07055	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EGM51_RS07070	COG0745	RESPONSE REGULATOR receiver
EGM51_RS07075	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
EGM51_RS07075	COG0316	Belongs to the HesB IscA family
EGM51_RS07085	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EGM51_RS07090	COG2124	cytochrome p450
EGM51_RS07095	COG0525	valine-tRNA ligase activity
EGM51_RS07105	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EGM51_RS07135	COG3425	synthase
EGM51_RS07145	COG0023	Translation Initiation Factor
EGM51_RS07150	COG2996	Protein conserved in bacteria
EGM51_RS07155	COG0513	Belongs to the DEAD box helicase family
EGM51_RS07180	COG2131	deaminase
EGM51_RS07190	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
EGM51_RS07190	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EGM51_RS07200	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
EGM51_RS07215	COG0159	tryptophan synthase activity
EGM51_RS07220	COG0848	biopolymer transport protein
EGM51_RS07225	COG0848	biopolymer transport protein
EGM51_RS07230	COG0811	peptide transport
EGM51_RS07275	COG2703	oxygen carrier activity
EGM51_RS07285	COG2738	Putative neutral zinc metallopeptidase
EGM51_RS07315	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EGM51_RS07350	COG0848	biopolymer transport protein
EGM51_RS07355	COG0811	peptide transport
EGM51_RS07405	COG0745	RESPONSE REGULATOR receiver
EGM51_RS07410	COG5002	protein histidine kinase activity
EGM51_RS07415	COG1283	sodium-dependent phosphate transmembrane transporter activity
EGM51_RS07435	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EGM51_RS07445	COG0581	inorganic phosphate transmembrane transporter activity
EGM51_RS07450	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EGM51_RS07455	COG0704	Plays a role in the regulation of phosphate uptake
EGM51_RS07485	COG0322	excinuclease ABC activity
EGM51_RS07510	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EGM51_RS07515	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
EGM51_RS07520	COG3005	denitrification pathway
EGM51_RS07525	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EGM51_RS07530	COG2226	methyltransferase
EGM51_RS07535	COG0571	ribonuclease III activity
EGM51_RS07545	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EGM51_RS07555	COG0747	negative chemotaxis
EGM51_RS07565	COG0149	triose-phosphate isomerase activity
EGM51_RS07580	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EGM51_RS07580	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EGM51_RS07620	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EGM51_RS07625	COG0154	amidase activity
EGM51_RS07630	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EGM51_RS07655	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EGM51_RS07670	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EGM51_RS07680	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
EGM51_RS07685	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EGM51_RS07710	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EGM51_RS07730	COG1528	Iron-storage protein
EGM51_RS07735	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EGM51_RS07755	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EGM51_RS07760	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EGM51_RS07790	COG1966	Carbon starvation protein
EGM51_RS07795	COG0302	gtp cyclohydrolase
EGM51_RS07810	COG3119	arylsulfatase activity
EGM51_RS07815	COG3083	sulfuric ester hydrolase activity
EGM51_RS07820	COG3119	arylsulfatase activity
EGM51_RS07830	COG3119	arylsulfatase activity
EGM51_RS07835	COG0667	Aldo Keto reductase
EGM51_RS07840	COG3250	beta-galactosidase activity
EGM51_RS07855	COG4573	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
EGM51_RS07860	COG1063	alcohol dehydrogenase
EGM51_RS07865	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EGM51_RS07870	COG0406	alpha-ribazole phosphatase activity
EGM51_RS07880	COG0738	Major facilitator superfamily
EGM51_RS07885	COG0656	L-ascorbic acid biosynthetic process
EGM51_RS07905	COG0129	dihydroxy-acid dehydratase activity
EGM51_RS07910	COG0402	S-adenosylhomocysteine deaminase activity
EGM51_RS07915	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EGM51_RS07955	COG0438	transferase activity, transferring glycosyl groups
EGM51_RS07980	COG0438	transferase activity, transferring glycosyl groups
EGM51_RS07995	COG0859	PFAM glycosyl transferase family 9
EGM51_RS08015	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EGM51_RS08030	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EGM51_RS08040	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
EGM51_RS08055	COG1088	dTDP-glucose 4,6-dehydratase activity
EGM51_RS08065	COG0529	Catalyzes the synthesis of activated sulfate
EGM51_RS08065	COG2895	sulfate adenylyltransferase (ATP) activity
EGM51_RS08075	COG0175	sulfate reduction
EGM51_RS08080	COG0471	metal ion transport
EGM51_RS08080	COG3273	potassium ion transport
EGM51_RS08090	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EGM51_RS08105	COG1256	bacterial-type flagellum assembly
EGM51_RS08105	COG4786	Flagellar basal body rod
EGM51_RS08120	COG1706	bacterial-type flagellum-dependent cell motility
EGM51_RS08130	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
EGM51_RS08145	COG4786	Flagellar basal body rod
EGM51_RS08150	COG1776	CheC inhibitor of MCP methylation
EGM51_RS08150	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EGM51_RS08155	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EGM51_RS08170	COG1360	Flagellar Motor Protein
EGM51_RS08175	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EGM51_RS08185	COG4786	Flagellar basal body rod
EGM51_RS08190	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
EGM51_RS08210	COG1157	protein secretion by the type III secretion system
EGM51_RS08220	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EGM51_RS08240	COG1815	bacterial-type flagellum-dependent cell motility
EGM51_RS08245	COG2204	response regulator
EGM51_RS08250	COG4566	intracellular signal transduction
EGM51_RS08260	COG4191	Histidine kinase
EGM51_RS08260	COG0784	Response regulator, receiver
EGM51_RS08265	COG1191	sigma factor activity
EGM51_RS08280	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EGM51_RS08285	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EGM51_RS08300	COG1338	Plays a role in the flagellum-specific transport system
EGM51_RS08320	COG2204	response regulator
EGM51_RS08325	COG5000	phosphorelay sensor kinase activity
EGM51_RS08330	COG2204	response regulator
EGM51_RS08345	COG0784	Response regulator, receiver
EGM51_RS08345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EGM51_RS08345	COG2198	Histidine kinase
EGM51_RS08345	COG2205	protein histidine kinase activity
EGM51_RS08355	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EGM51_RS08360	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
EGM51_RS08370	COG0367	asparagine synthase
EGM51_RS08375	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
EGM51_RS08380	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EGM51_RS08385	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EGM51_RS08390	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EGM51_RS08395	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EGM51_RS08415	COG0784	Response regulator, receiver
EGM51_RS08415	COG2205	protein histidine kinase activity
EGM51_RS08425	COG0745	RESPONSE REGULATOR receiver
EGM51_RS08450	COG1011	Hydrolase
EGM51_RS08460	COG1187	pseudouridine synthase activity
EGM51_RS08485	COG0569	domain protein
EGM51_RS08495	COG0366	Alpha amylase catalytic
EGM51_RS08500	COG0297	glycogen (starch) synthase activity
EGM51_RS08505	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EGM51_RS08520	COG0028	Belongs to the TPP enzyme family
EGM51_RS08535	COG1113	amino acid transport
EGM51_RS08540	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EGM51_RS08550	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
EGM51_RS08605	COG0450	alkyl hydroperoxide reductase
EGM51_RS08610	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EGM51_RS08620	COG1686	Belongs to the peptidase S11 family
EGM51_RS08630	COG0544	peptidyl-prolyl cis-trans isomerase activity
EGM51_RS08635	COG0740	serine-type endopeptidase activity
EGM51_RS08640	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EGM51_RS08665	COG0588	phosphoglycerate mutase activity
EGM51_RS08675	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EGM51_RS08695	COG0546	phosphoglycolate phosphatase activity
EGM51_RS08705	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EGM51_RS08720	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EGM51_RS08725	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EGM51_RS08740	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EGM51_RS08765	COG0673	inositol 2-dehydrogenase activity
EGM51_RS08770	COG0673	inositol 2-dehydrogenase activity
EGM51_RS08775	COG0673	inositol 2-dehydrogenase activity
EGM51_RS08805	COG4988	ABC transporter
EGM51_RS08810	COG0390	transport system, permease component
EGM51_RS08820	COG0473	3-isopropylmalate dehydrogenase activity
EGM51_RS08825	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EGM51_RS08845	COG2239	Acts as a magnesium transporter
EGM51_RS08850	COG1381	Involved in DNA repair and RecF pathway recombination
EGM51_RS08860	COG1215	transferase activity, transferring glycosyl groups
EGM51_RS08865	COG0463	Glycosyl transferase, family 2
EGM51_RS08870	COG1083	cytidylyl-transferase
EGM51_RS08915	COG1215	transferase activity, transferring glycosyl groups
EGM51_RS08940	COG0438	transferase activity, transferring glycosyl groups
EGM51_RS08945	COG1185	polyribonucleotide nucleotidyltransferase activity
EGM51_RS08950	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EGM51_RS08955	COG3119	arylsulfatase activity
EGM51_RS08965	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EGM51_RS08970	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EGM51_RS08975	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EGM51_RS08985	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EGM51_RS09000	COG0126	phosphoglycerate kinase activity
EGM51_RS09025	COG1730	sister chromatid segregation
EGM51_RS09030	COG4659	FMN binding
EGM51_RS09050	COG0492	ferredoxin-NADP+ reductase activity
EGM51_RS09055	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EGM51_RS09070	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EGM51_RS09085	COG0504	CTP synthase activity
EGM51_RS09100	COG2135	peptidase activity
EGM51_RS09105	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EGM51_RS09115	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EGM51_RS09120	COG0215	cysteine-tRNA ligase activity
EGM51_RS09125	COG0799	negative regulation of ribosome biogenesis
EGM51_RS09130	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EGM51_RS09140	COG0489	protein tyrosine kinase activity
EGM51_RS09145	COG3944	biosynthesis protein
EGM51_RS09170	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EGM51_RS09175	COG0848	biopolymer transport protein
EGM51_RS09180	COG0848	biopolymer transport protein
EGM51_RS09205	COG0254	rRNA binding
EGM51_RS09210	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EGM51_RS09225	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EGM51_RS09245	COG0811	peptide transport
EGM51_RS09265	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EGM51_RS09270	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EGM51_RS09310	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EGM51_RS09315	COG0330	HflC and HflK could
EGM51_RS09325	COG1028	Short-chain dehydrogenase reductase Sdr
EGM51_RS09335	COG2832	Protein of unknown function (DUF454)
EGM51_RS09340	COG0011	TIGRFAM Protein of
EGM51_RS09345	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EGM51_RS09390	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EGM51_RS09395	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EGM51_RS09405	COG0519	Catalyzes the synthesis of GMP from XMP
EGM51_RS09415	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EGM51_RS09475	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EGM51_RS09480	COG0352	thiamine-phosphate diphosphorylase activity
EGM51_RS09485	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
EGM51_RS09505	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EGM51_RS09515	COG2130	NADP-dependent
EGM51_RS09520	COG1979	alcohol dehydrogenase
EGM51_RS09530	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EGM51_RS09545	COG1309	transcriptional regulator
EGM51_RS09600	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EGM51_RS09615	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
EGM51_RS09620	COG2226	methyltransferase
EGM51_RS09625	COG0163	prenyltransferase activity
EGM51_RS09630	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EGM51_RS09635	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
EGM51_RS09640	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EGM51_RS09645	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EGM51_RS09670	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EGM51_RS09680	COG0523	cobalamin synthesis protein
EGM51_RS09685	COG0488	(ABC) transporter
EGM51_RS09695	COG2814	Major facilitator Superfamily
EGM51_RS09710	COG1904	glucuronate isomerase
EGM51_RS09720	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
EGM51_RS09725	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EGM51_RS09730	COG1312	Catalyzes the dehydration of D-mannonate
EGM51_RS09735	COG0784	Response regulator, receiver
EGM51_RS09735	COG2205	protein histidine kinase activity
EGM51_RS09770	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
EGM51_RS09890	COG3415	Transposase
EGM51_RS09890	COG2801	Transposase and inactivated derivatives
EGM51_RS09945	COG4372	Transposase
EGM51_RS09980	COG3547	Transposase (IS116 IS110 IS902 family)
EGM51_RS09995	COG4232	protein-disulfide reductase activity
EGM51_RS10000	COG0617	tRNA 3'-terminal CCA addition
EGM51_RS10015	COG1127	ABC transporter
EGM51_RS10020	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EGM51_RS10040	COG1045	serine acetyltransferase
EGM51_RS10045	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EGM51_RS10050	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EGM51_RS10055	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EGM51_RS10060	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EGM51_RS10065	COG0211	Belongs to the bacterial ribosomal protein bL27 family
EGM51_RS10070	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EGM51_RS10115	COG1047	Peptidyl-prolyl cis-trans
EGM51_RS10120	COG2081	HI0933 family
EGM51_RS10135	COG3228	Belongs to the MtfA family
EGM51_RS10145	COG0702	epimerase
EGM51_RS10160	COG1214	PFAM Peptidase M22, glycoprotease
EGM51_RS10165	COG0802	atpase or kinase
EGM51_RS10175	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EGM51_RS10205	COG2890	protein-(glutamine-N5) methyltransferase activity
EGM51_RS10225	COG1929	Belongs to the glycerate kinase type-1 family
EGM51_RS10230	COG1609	Transcriptional regulator
EGM51_RS10240	COG1120	ATPase activity
EGM51_RS10245	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EGM51_RS10250	COG1492	cobalamin metabolic process
EGM51_RS10255	COG0519	Catalyzes the synthesis of GMP from XMP
EGM51_RS10265	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EGM51_RS10280	COG1674	ftsk spoiiie
EGM51_RS10285	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
EGM51_RS10295	COG0280	phosphate acetyltransferase
EGM51_RS10300	COG0203	ribosomal protein L17
EGM51_RS10305	COG0202	RNA polymerase activity
EGM51_RS10310	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EGM51_RS10315	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EGM51_RS10320	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EGM51_RS10325	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EGM51_RS10330	COG0024	Methionine aminopeptidase
EGM51_RS10340	COG0201	protein transport
EGM51_RS10350	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
EGM51_RS10355	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EGM51_RS10360	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
EGM51_RS10370	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EGM51_RS10375	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EGM51_RS10380	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EGM51_RS10390	COG0255	Belongs to the universal ribosomal protein uL29 family
EGM51_RS10395	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EGM51_RS10400	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EGM51_RS10405	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EGM51_RS10410	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EGM51_RS10415	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EGM51_RS10420	COG0089	rRNA binding
EGM51_RS10425	COG0088	Forms part of the polypeptide exit tunnel
EGM51_RS10430	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EGM51_RS10435	COG0051	transcription antitermination factor activity, RNA binding
EGM51_RS10440	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EGM51_RS10445	COG0049	tRNA binding
EGM51_RS10450	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EGM51_RS10455	COG1278	Cold shock
EGM51_RS10470	COG2169	Transcriptional regulator
EGM51_RS10470	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EGM51_RS10475	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EGM51_RS10480	COG0085	RNA polymerase activity
EGM51_RS10485	COG0222	ribosome binding
EGM51_RS10495	COG0081	regulation of translation
EGM51_RS10500	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EGM51_RS10505	COG0250	Participates in transcription elongation, termination and antitermination
EGM51_RS10510	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EGM51_RS10520	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EGM51_RS10525	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EGM51_RS10535	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EGM51_RS10555	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EGM51_RS10740	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EGM51_RS10770	COG1410	methionine synthase
EGM51_RS10770	COG0646	methionine synthase
EGM51_RS10775	COG0646	methionine synthase
EGM51_RS10775	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EGM51_RS10790	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EGM51_RS10795	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EGM51_RS10805	COG1074	ATP-dependent DNA helicase activity
EGM51_RS10810	COG1074	ATP-dependent DNA helicase activity
EGM51_RS10820	COG0463	Glycosyl transferase, family 2
EGM51_RS10830	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EGM51_RS10835	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EGM51_RS10855	COG1131	(ABC) transporter
EGM51_RS10880	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EGM51_RS10890	COG0012	GTP binding
EGM51_RS10895	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EGM51_RS10910	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EGM51_RS10915	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EGM51_RS10930	COG0352	thiamine-phosphate diphosphorylase activity
EGM51_RS10955	COG1119	ATPase activity
EGM51_RS10970	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EGM51_RS10980	COG1611	Belongs to the LOG family
EGM51_RS10995	COG0501	Belongs to the peptidase M48B family
EGM51_RS11000	COG1475	DNA binding
EGM51_RS11020	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
EGM51_RS11035	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EGM51_RS11050	COG0439	Biotin carboxylase
EGM51_RS11055	COG0511	ligase activity, forming carbon-carbon bonds
EGM51_RS11065	COG0673	inositol 2-dehydrogenase activity
EGM51_RS11080	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EGM51_RS11090	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EGM51_RS11110	COG0513	Belongs to the DEAD box helicase family
EGM51_RS11115	COG0138	bifunctional purine biosynthesis protein purh
EGM51_RS11120	COG1272	protein, Hemolysin III
EGM51_RS11125	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EGM51_RS11130	COG2848	UPF0210 protein
EGM51_RS11135	COG3830	Belongs to the UPF0237 family
EGM51_RS11165	COG1294	oxidase, subunit
EGM51_RS11170	COG1271	oxidase subunit
EGM51_RS11175	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EGM51_RS11195	COG2217	Heavy metal translocating P-type atpase
EGM51_RS11245	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EGM51_RS11260	COG0493	'glutamate synthase
EGM51_RS11265	COG1278	Cold shock
EGM51_RS11275	COG1051	belongs to the nudix hydrolase family
EGM51_RS11280	COG0668	transmembrane transport
EGM51_RS11285	COG0646	methionine synthase
EGM51_RS11285	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EGM51_RS11290	COG0668	transmembrane transport
EGM51_RS11305	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EGM51_RS11315	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EGM51_RS11325	COG2233	PERMEase
EGM51_RS11330	COG2183	response to ionizing radiation
EGM51_RS11340	COG0038	chloride channel
EGM51_RS11355	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EGM51_RS11360	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EGM51_RS11365	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EGM51_RS11375	COG0137	argininosuccinate synthase activity
EGM51_RS11385	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EGM51_RS11390	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EGM51_RS11395	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
EGM51_RS11400	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EGM51_RS11405	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EGM51_RS11440	COG0268	Binds directly to 16S ribosomal RNA
EGM51_RS11450	COG0481	GTPase activity
EGM51_RS11460	COG0543	2 iron, 2 sulfur cluster binding
EGM51_RS11465	COG0167	dihydroorotate dehydrogenase activity
EGM51_RS11515	COG0515	serine threonine protein kinase
EGM51_RS11515	COG0457	Tetratricopeptide repeat
EGM51_RS11525	COG0534	Mate efflux family protein
EGM51_RS11535	COG1785	Belongs to the alkaline phosphatase family
EGM51_RS11575	COG1566	PFAM secretion protein HlyD family protein
EGM51_RS11585	COG0534	Mate efflux family protein
EGM51_RS11595	COG0194	GDP metabolic process
EGM51_RS11600	COG1561	YicC-like family, N-terminal region
EGM51_RS11665	COG0133	tryptophan synthase activity
EGM51_RS11675	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EGM51_RS11680	COG0135	phosphoribosylanthranilate isomerase activity
EGM51_RS11685	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
EGM51_RS11690	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EGM51_RS11700	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EGM51_RS11705	COG3494	Protein of unknown function (DUF1009)
EGM51_RS11730	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
EGM51_RS11760	COG1609	Transcriptional regulator
EGM51_RS11825	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EGM51_RS11850	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EGM51_RS11870	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EGM51_RS11880	COG0459	protein refolding
EGM51_RS11885	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EGM51_RS11890	COG0443	Heat shock 70 kDa protein
EGM51_RS11900	COG2095	MarC family integral membrane protein
EGM51_RS11920	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EGM51_RS11925	COG1720	tRNA m6t6A37 methyltransferase activity
EGM51_RS11945	COG3661	Belongs to the glycosyl hydrolase 67 family
EGM51_RS11955	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
EGM51_RS11960	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EGM51_RS11970	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
EGM51_RS11980	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
EGM51_RS11985	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
EGM51_RS11990	COG4677	pectinesterase activity
EGM51_RS12025	COG2197	response regulator
EGM51_RS12030	COG4677	pectinesterase activity
EGM51_RS12045	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EGM51_RS12060	COG3119	arylsulfatase activity
EGM51_RS12065	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
EGM51_RS12065	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
EGM51_RS12095	COG2801	Transposase and inactivated derivatives
EGM51_RS12095	COG3415	Transposase
EGM51_RS12115	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
EGM51_RS12120	COG0347	Belongs to the P(II) protein family
EGM51_RS12125	COG0347	Belongs to the P(II) protein family
EGM51_RS12160	COG1433	Dinitrogenase iron-molybdenum cofactor
EGM51_RS12160	COG0535	radical SAM domain protein
EGM51_RS12185	COG0725	ABC transporter, periplasmic molybdate-binding protein
EGM51_RS12195	COG0725	ABC transporter, periplasmic molybdate-binding protein
EGM51_RS12205	COG4149	molybdate abc transporter
EGM51_RS12210	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
EGM51_RS12220	COG3773	Cell wall hydrolase
EGM51_RS12235	COG1355	regulation of microtubule-based process
EGM51_RS12290	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EGM51_RS12305	COG4206	TonB-dependent receptor
EGM51_RS12325	COG1061	Type III restriction enzyme res subunit
EGM51_RS12380	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EGM51_RS12395	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EGM51_RS12430	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
EGM51_RS12440	COG0457	Tetratricopeptide repeat
EGM51_RS12455	COG2207	Transcriptional regulator
EGM51_RS12455	COG1917	Cupin 2, conserved barrel domain protein
EGM51_RS12460	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EGM51_RS12465	COG2165	general secretion pathway protein
EGM51_RS12470	COG2165	general secretion pathway protein
EGM51_RS12475	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EGM51_RS12480	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EGM51_RS12490	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EGM51_RS12500	COG0386	Belongs to the glutathione peroxidase family
EGM51_RS12510	COG1404	Belongs to the peptidase S8 family
EGM51_RS12525	COG3848	Pyruvate phosphate dikinase
EGM51_RS12525	COG0574	Belongs to the PEP-utilizing enzyme family
EGM51_RS12545	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
EGM51_RS12555	COG0436	Aminotransferase
EGM51_RS12560	COG1522	sequence-specific DNA binding
EGM51_RS12585	COG0285	dihydrofolate synthase activity
EGM51_RS12590	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EGM51_RS12595	COG1040	competence protein
EGM51_RS12605	COG0084	hydrolase, TatD family'
EGM51_RS12655	COG0606	chelatase, subunit chli
EGM51_RS12665	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EGM51_RS12675	COG2363	Small membrane protein
EGM51_RS12685	COG3256	nitric oxide reductase
EGM51_RS12690	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
EGM51_RS12695	COG3189	MarR family transcriptional regulator
EGM51_RS12700	COG1794	racemase activity, acting on amino acids and derivatives
EGM51_RS12705	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EGM51_RS12710	COG3263	regulation of cellular component size
EGM51_RS12720	COG4191	Histidine kinase
EGM51_RS12725	COG2204	response regulator
EGM51_RS12730	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EGM51_RS12740	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EGM51_RS12750	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EGM51_RS12765	COG0259	pyridoxamine-phosphate oxidase activity
EGM51_RS12770	COG0348	domain, Protein
EGM51_RS12780	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
EGM51_RS12805	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EGM51_RS12810	COG0798	PFAM Bile acid sodium symporter
EGM51_RS12815	COG0640	Transcriptional regulator
EGM51_RS12865	COG3209	COG3209 Rhs family protein
EGM51_RS12895	COG0347	Belongs to the P(II) protein family
EGM51_RS12900	COG0004	ammonium transporteR
EGM51_RS12905	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
EGM51_RS12910	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
EGM51_RS12925	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EGM51_RS12930	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EGM51_RS12935	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
EGM51_RS12940	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EGM51_RS12945	COG2267	carboxylic ester hydrolase activity
EGM51_RS12955	COG0577	efflux transmembrane transporter activity
EGM51_RS12955	COG1136	(ABC) transporter
EGM51_RS12960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EGM51_RS12980	COG4106	trans-aconitate 2-methyltransferase activity
EGM51_RS12985	COG0500	methyltransferase
EGM51_RS12990	COG0583	DNA-binding transcription factor activity
EGM51_RS13005	COG1733	regulation of RNA biosynthetic process
EGM51_RS13025	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EGM51_RS13025	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EGM51_RS13030	COG1396	sequence-specific DNA binding
EGM51_RS13055	COG3177	Filamentation induced by cAMP protein fic
EGM51_RS13085	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
EGM51_RS13105	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EGM51_RS13115	COG0424	maF-like protein
EGM51_RS13130	COG2205	protein histidine kinase activity
EGM51_RS13130	COG0784	Response regulator, receiver
EGM51_RS13130	COG5002	protein histidine kinase activity
EGM51_RS13165	COG3720	iron ion transport
EGM51_RS13170	COG1959	2 iron, 2 sulfur cluster binding
EGM51_RS13175	COG4206	TonB-dependent receptor
EGM51_RS13225	COG0811	peptide transport
EGM51_RS13230	COG0811	peptide transport
EGM51_RS13235	COG0848	biopolymer transport protein
EGM51_RS13275	COG0848	biopolymer transport protein
EGM51_RS13280	COG0811	peptide transport
EGM51_RS13285	COG0811	peptide transport
EGM51_RS13295	COG1120	ATPase activity
EGM51_RS13305	COG0667	Aldo Keto reductase
EGM51_RS13310	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EGM51_RS13350	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EGM51_RS13400	COG0543	2 iron, 2 sulfur cluster binding
EGM51_RS13405	COG0493	'glutamate synthase
EGM51_RS13410	COG0493	'glutamate synthase
EGM51_RS13415	COG0069	glutamate synthase activity
EGM51_RS13415	COG0067	glutamate synthase
EGM51_RS13415	COG0070	glutamate synthase
EGM51_RS13435	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EGM51_RS13450	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EGM51_RS13455	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
EGM51_RS13465	COG0731	radical SAM domain protein
EGM51_RS13465	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EGM51_RS13470	COG2133	pyrroloquinoline quinone binding
EGM51_RS13475	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EGM51_RS13490	COG0358	DNA primase activity
EGM51_RS13520	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EGM51_RS13545	COG4221	oxidoreductase activity
EGM51_RS13555	COG2770	Histidine kinase
EGM51_RS13555	COG2208	phosphoserine phosphatase activity
EGM51_RS13575	COG1132	(ABC) transporter
EGM51_RS13605	COG1414	Transcriptional regulator
EGM51_RS13610	COG1049	propionate catabolic process, 2-methylcitrate cycle
EGM51_RS13625	COG0242	peptide deformylase activity
EGM51_RS13650	COG1295	ribonuclease BN
EGM51_RS13660	COG0129	dihydroxy-acid dehydratase activity
EGM51_RS13670	COG0667	Aldo Keto reductase
EGM51_RS13675	COG1028	Short-chain dehydrogenase reductase Sdr
EGM51_RS13685	COG0156	8-amino-7-oxononanoate synthase activity
EGM51_RS13690	COG2267	carboxylic ester hydrolase activity
EGM51_RS13695	COG0189	ligase activity
EGM51_RS13695	COG4067	protein conserved in archaea
EGM51_RS13700	COG0189	ligase activity
EGM51_RS13720	COG0598	Magnesium transport protein CorA
EGM51_RS13745	COG4106	trans-aconitate 2-methyltransferase activity
EGM51_RS13760	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
EGM51_RS13785	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EGM51_RS13790	COG0300	oxidoreductase activity
EGM51_RS13800	COG3852	Histidine kinase
EGM51_RS13805	COG2067	long-chain fatty acid transport protein
EGM51_RS13815	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EGM51_RS13820	COG3852	Histidine kinase
EGM51_RS13835	COG0589	response to stress
EGM51_RS13840	COG0714	Associated with various cellular activities
EGM51_RS13865	COG2304	oxidoreductase activity
EGM51_RS13900	COG0131	Imidazoleglycerol-phosphate dehydratase
EGM51_RS13905	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EGM51_RS13910	COG4589	Belongs to the CDS family
EGM51_RS13935	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
EGM51_RS13940	COG0071	Belongs to the small heat shock protein (HSP20) family
EGM51_RS13960	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EGM51_RS13965	COG0045	succinate-CoA ligase (ADP-forming) activity
EGM51_RS13975	COG1053	succinate dehydrogenase
EGM51_RS14025	COG2161	toxin-antitoxin pair type II binding
EGM51_RS14040	COG2957	Belongs to the agmatine deiminase family
EGM51_RS14055	COG0653	protein targeting
EGM51_RS14060	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EGM51_RS14065	COG0288	reversible hydration of carbon dioxide
EGM51_RS14080	COG0659	secondary active sulfate transmembrane transporter activity
EGM51_RS14105	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EGM51_RS14105	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EGM51_RS14105	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EGM51_RS14115	COG0489	protein tyrosine kinase activity
EGM51_RS14120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EGM51_RS14130	COG0489	protein tyrosine kinase activity
EGM51_RS14145	COG1342	Belongs to the UPF0251 family
EGM51_RS14155	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EGM51_RS14170	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EGM51_RS14180	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
EGM51_RS14200	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EGM51_RS14205	COG2723	6-phospho-beta-galactosidase activity
EGM51_RS14210	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EGM51_RS14220	COG0778	Nitroreductase
EGM51_RS14225	COG3170	Tfp pilus assembly protein FimV
EGM51_RS14225	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EGM51_RS14250	COG1293	RNA-binding protein homologous to eukaryotic snRNP
EGM51_RS14270	COG1846	Transcriptional regulator
EGM51_RS14275	COG0702	epimerase
EGM51_RS14280	COG2015	COG2015, Alkyl sulfatase and related hydrolases
EGM51_RS14295	COG2261	transglycosylase associated protein
EGM51_RS14320	COG0426	domain, Protein
EGM51_RS14325	COG1959	2 iron, 2 sulfur cluster binding
EGM51_RS14330	COG1132	(ABC) transporter
EGM51_RS14335	COG1448	Aminotransferase
EGM51_RS14345	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EGM51_RS14345	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EGM51_RS14380	COG0039	L-malate dehydrogenase activity
EGM51_RS14385	COG0490	domain, Protein
EGM51_RS14385	COG2985	domain, Protein
EGM51_RS14400	COG4948	Mandelate Racemase Muconate Lactonizing
EGM51_RS14405	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EGM51_RS14410	COG1609	Transcriptional regulator
EGM51_RS14420	COG2860	membrane
EGM51_RS14430	COG3250	beta-galactosidase activity
EGM51_RS14440	COG0516	GMP reductase activity
EGM51_RS14445	COG1704	LemA family
EGM51_RS14490	COG0596	Alpha beta hydrolase
EGM51_RS14490	COG0508	dehydrogenase complex catalyzes the overall conversion of
EGM51_RS14495	COG0604	alcohol dehydrogenase
EGM51_RS14520	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
EGM51_RS14555	COG0829	nickel cation binding
EGM51_RS14560	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
EGM51_RS14565	COG0830	nickel cation binding
EGM51_RS14570	COG0804	urea catabolic process
EGM51_RS14605	COG0683	leucine binding
EGM51_RS14655	COG1459	type II secretion system
EGM51_RS14660	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EGM51_RS14665	COG1450	Type ii and iii secretion system protein
EGM51_RS14690	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EGM51_RS14695	COG0592	DNA-directed DNA polymerase activity
EGM51_RS14725	COG0445	tRNA wobble uridine modification
EGM51_RS14745	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
EGM51_RS14750	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EGM51_RS14755	COG0321	lipoyl(octanoyl) transferase activity
EGM51_RS14755	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
EGM51_RS14770	COG1215	transferase activity, transferring glycosyl groups
EGM51_RS14775	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
EGM51_RS14795	COG1070	Carbohydrate kinase
EGM51_RS14800	COG2115	Belongs to the xylose isomerase family
EGM51_RS14805	COG0477	Major facilitator Superfamily
EGM51_RS14835	COG0673	inositol 2-dehydrogenase activity
EGM51_RS14860	COG0673	inositol 2-dehydrogenase activity
EGM51_RS14870	COG3708	Transcriptional regulator
EGM51_RS14870	COG2207	Transcriptional regulator
EGM51_RS14915	COG1489	DNA binding
EGM51_RS14945	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EGM51_RS14965	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EGM51_RS14980	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
EGM51_RS14985	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EGM51_RS15000	COG0356	it plays a direct role in the translocation of protons across the membrane
EGM51_RS15010	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EGM51_RS15015	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EGM51_RS15025	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EGM51_RS15030	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EGM51_RS15035	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EGM51_RS15045	COG0776	regulation of translation
EGM51_RS15055	COG0475	glutathione-regulated potassium exporter activity
EGM51_RS15070	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EGM51_RS15085	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EGM51_RS15090	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EGM51_RS15095	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
EGM51_RS15105	COG4628	conserved protein (DUF2132)
EGM51_RS15140	COG1160	GTP binding
EGM51_RS15145	COG0501	Belongs to the peptidase M48B family
EGM51_RS15150	COG1704	LemA family
EGM51_RS15155	COG0776	regulation of translation
EGM51_RS15165	COG1505	serine-type exopeptidase activity
EGM51_RS15175	COG1129	ABC transporter
EGM51_RS15180	COG4372	Transposase
EGM51_RS15240	COG0110	maltose O-acetyltransferase activity
EGM51_RS15270	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EGM51_RS15330	COG2251	uridine kinase activity
EGM51_RS15330	COG0195	Participates in both transcription termination and antitermination
EGM51_RS15335	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EGM51_RS15345	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EGM51_RS15370	COG0134	indole-3-glycerol-phosphate synthase activity
EGM51_RS15390	COG1450	Type ii and iii secretion system protein
EGM51_RS15395	COG2176	DNA-directed DNA polymerase activity
EGM51_RS15405	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EGM51_RS15410	COG1595	DNA-templated transcription, initiation
EGM51_RS15430	COG2226	methyltransferase
EGM51_RS15440	COG2801	Transposase and inactivated derivatives
EGM51_RS15440	COG3415	Transposase
EGM51_RS15445	COG0398	Pfam SNARE associated Golgi protein
EGM51_RS15475	COG0811	peptide transport
EGM51_RS15485	COG0848	biopolymer transport protein
EGM51_RS15505	COG0022	dehydrogenase e1 component
EGM51_RS15515	COG0004	ammonium transporteR
EGM51_RS15530	COG0583	DNA-binding transcription factor activity
EGM51_RS15535	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EGM51_RS15550	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EGM51_RS15560	COG0745	RESPONSE REGULATOR receiver
EGM51_RS15570	COG3530	Putative quorum-sensing-regulated virulence factor
EGM51_RS15585	COG2192	nodulation
EGM51_RS15590	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
EGM51_RS15605	COG1132	(ABC) transporter
EGM51_RS15625	COG0745	RESPONSE REGULATOR receiver
EGM51_RS15630	COG2198	Histidine kinase
EGM51_RS15630	COG5002	protein histidine kinase activity
EGM51_RS15630	COG0784	Response regulator, receiver
EGM51_RS15640	COG0438	transferase activity, transferring glycosyl groups
EGM51_RS15650	COG3279	Response regulator of the LytR AlgR family
EGM51_RS15670	COG5001	Diguanylate cyclase
EGM51_RS15680	COG4251	negative regulation of phosphorylation
EGM51_RS15685	COG0784	Response regulator, receiver
EGM51_RS15690	COG4191	Histidine kinase
EGM51_RS15695	COG4191	Histidine kinase
EGM51_RS15695	COG0784	Response regulator, receiver
EGM51_RS15705	COG1530	ribonuclease E activity
EGM51_RS15710	COG0772	Belongs to the SEDS family
EGM51_RS15715	COG0768	penicillin binding
EGM51_RS15775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EGM51_RS15805	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
EGM51_RS15815	COG2081	HI0933 family
EGM51_RS15840	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EGM51_RS15845	COG0484	heat shock protein binding
EGM51_RS15855	COG1192	Involved in chromosome partitioning
EGM51_RS15865	COG5654	RES domain protein
EGM51_RS15880	COG0673	inositol 2-dehydrogenase activity
EGM51_RS15890	COG3850	Histidine kinase
EGM51_RS15920	COG3119	arylsulfatase activity
EGM51_RS15955	COG3250	beta-galactosidase activity
EGM51_RS15985	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EGM51_RS15990	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EGM51_RS15995	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EGM51_RS16005	COG0742	ribosomal rna small subunit methyltransferase
EGM51_RS16010	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EGM51_RS16015	COG4206	TonB-dependent receptor
EGM51_RS16025	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EGM51_RS16030	COG1121	(ABC) transporter
EGM51_RS16040	COG3746	phosphate-selective porin O and P
EGM51_RS16060	COG0488	(ABC) transporter
EGM51_RS16075	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EGM51_RS16105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EGM51_RS16160	COG3118	belongs to the thioredoxin family
EGM51_RS16170	COG0450	alkyl hydroperoxide reductase
EGM51_RS16190	COG1643	Atp-dependent helicase
EGM51_RS16195	COG0673	inositol 2-dehydrogenase activity
EGM51_RS16225	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EGM51_RS16230	COG0037	tRNA processing
EGM51_RS16240	COG0653	protein targeting
EGM51_RS16245	COG0653	protein targeting
EGM51_RS16255	COG1515	deoxyribonuclease V activity
EGM51_RS16260	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EGM51_RS16300	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EGM51_RS16305	COG0419	ATPase involved in DNA repair
EGM51_RS16325	COG0420	3'-5' exonuclease activity
EGM51_RS16330	COG0113	porphobilinogen synthase activity
EGM51_RS16335	COG0428	transporter
EGM51_RS16370	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
EGM51_RS16380	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EGM51_RS16390	COG0483	inositol monophosphate 1-phosphatase activity
EGM51_RS16400	COG4864	UPF0365 protein
EGM51_RS16410	COG1030	water channel activity
EGM51_RS16420	COG0148	phosphopyruvate hydratase activity
EGM51_RS16430	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EGM51_RS16440	COG0084	hydrolase, TatD family'
EGM51_RS16485	COG0563	adenylate kinase activity
EGM51_RS16490	COG0563	adenylate kinase activity
EGM51_RS16520	COG2255	four-way junction helicase activity
EGM51_RS16525	COG0632	four-way junction helicase activity
EGM51_RS16530	COG1217	gtp-binding protein TYPA
EGM51_RS16535	COG0724	RNA recognition motif
EGM51_RS16570	COG0604	alcohol dehydrogenase
EGM51_RS16570	COG3321	synthase
EGM51_RS16580	COG0778	Nitroreductase
EGM51_RS16585	COG0778	Nitroreductase
EGM51_RS16590	COG1309	transcriptional regulator
EGM51_RS16625	COG1337	RAMP superfamily
EGM51_RS16665	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
EGM51_RS16705	COG0826	peptidase U32
EGM51_RS16715	COG2022	thiamine diphosphate biosynthetic process
EGM51_RS16720	COG2022	thiamine diphosphate biosynthetic process
EGM51_RS16720	COG2104	thiamine diphosphate biosynthetic process
EGM51_RS16750	COG0823	Involved in the tonB-independent uptake of proteins
EGM51_RS16765	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
EGM51_RS16770	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
EGM51_RS16770	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EGM51_RS16775	COG0205	6-phosphofructokinase activity
EGM51_RS16780	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EGM51_RS16795	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EGM51_RS16800	COG3977	Valine--pyruvate aminotransferase
EGM51_RS16810	COG0640	Transcriptional regulator
EGM51_RS16825	COG3118	belongs to the thioredoxin family
EGM51_RS16840	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EGM51_RS16855	COG0864	Transcriptional regulator
EGM51_RS16865	COG3665	Urea carboxylase-associated protein
EGM51_RS16880	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EGM51_RS16915	COG2957	Belongs to the agmatine deiminase family
EGM51_RS16920	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EGM51_RS16925	COG1454	alcohol dehydrogenase
EGM51_RS16930	COG1012	belongs to the aldehyde dehydrogenase family
EGM51_RS16950	COG1748	Saccharopine dehydrogenase
EGM51_RS16970	COG0626	cystathionine gamma-synthase activity
EGM51_RS16980	COG1166	arginine decarboxylase activity
EGM51_RS17035	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
EGM51_RS17065	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EGM51_RS17090	COG1490	D-aminoacyl-tRNA deacylase activity
EGM51_RS17095	COG0165	Argininosuccinate lyase
EGM51_RS17115	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EGM51_RS17120	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
EGM51_RS17125	COG0193	aminoacyl-tRNA hydrolase activity
EGM51_RS17135	COG0629	single-stranded DNA binding
EGM51_RS17140	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
EGM51_RS17145	COG0359	binds to the 23S rRNA
EGM51_RS17150	COG0305	Participates in initiation and elongation during chromosome replication
EGM51_RS17165	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EGM51_RS17170	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EGM51_RS17180	COG1283	sodium-dependent phosphate transmembrane transporter activity
EGM51_RS17235	COG0180	Tryptophanyl-tRNA synthetase
EGM51_RS17245	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EGM51_RS17250	COG1605	Chorismate mutase
EGM51_RS17250	COG0077	Prephenate dehydratase
EGM51_RS17260	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EGM51_RS17265	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EGM51_RS17290	COG1459	type II secretion system
EGM51_RS17300	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EGM51_RS17305	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EGM51_RS17315	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EGM51_RS17330	COG0084	hydrolase, TatD family'
EGM51_RS17350	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EGM51_RS17360	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EGM51_RS17370	COG1692	metallophosphoesterase
EGM51_RS17400	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EGM51_RS17400	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EGM51_RS17405	COG1058	Belongs to the CinA family
EGM51_RS17405	COG1546	Belongs to the CinA family
EGM51_RS17420	COG1573	uracil-dna glycosylase
EGM51_RS17435	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EGM51_RS17440	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EGM51_RS17450	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EGM51_RS17460	COG0546	phosphoglycolate phosphatase activity
EGM51_RS17460	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EGM51_RS17465	COG3030	protein affecting phage T7 exclusion by the F plasmid
EGM51_RS17475	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
EGM51_RS17475	COG0517	IMP dehydrogenase activity
EGM51_RS17500	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EGM51_RS17505	COG0539	negative regulation of cytoplasmic translation
EGM51_RS17510	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EGM51_RS17515	COG0217	transcriptional regulatory protein
EGM51_RS17525	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
EGM51_RS17540	COG1592	Rubrerythrin
EGM51_RS17550	COG0069	glutamate synthase activity
EGM51_RS17555	COG0028	Belongs to the TPP enzyme family
EGM51_RS17575	COG3634	alkyl hydroperoxide reductase activity
EGM51_RS17580	COG0450	alkyl hydroperoxide reductase
EGM51_RS17600	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EGM51_RS17605	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EGM51_RS17605	COG0758	DNA mediated transformation
EGM51_RS17610	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EGM51_RS17615	COG4974	Belongs to the 'phage' integrase family
EGM51_RS17660	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EGM51_RS17665	COG0095	Lipoate-protein ligase
EGM51_RS17675	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
EGM51_RS17675	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EGM51_RS17700	COG1414	Transcriptional regulator
EGM51_RS17705	COG2207	Transcriptional regulator
EGM51_RS17725	COG3507	Belongs to the glycosyl hydrolase 43 family
EGM51_RS17730	COG3507	Belongs to the glycosyl hydrolase 43 family
EGM51_RS17735	COG3661	Belongs to the glycosyl hydrolase 67 family
EGM51_RS17740	COG2382	esterase
EGM51_RS17740	COG3507	Belongs to the glycosyl hydrolase 43 family
EGM51_RS17740	COG3693	PFAM glycoside hydrolase, family 10
EGM51_RS17765	COG5492	domain, Protein
EGM51_RS17800	COG3119	arylsulfatase activity
EGM51_RS17820	COG5002	protein histidine kinase activity
EGM51_RS17820	COG3850	Histidine kinase
EGM51_RS17825	COG0745	RESPONSE REGULATOR receiver
EGM51_RS17835	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
EGM51_RS17845	COG1053	succinate dehydrogenase
EGM51_RS17895	COG4968	Prepilin-type N-terminal cleavage methylation domain
EGM51_RS17900	COG2204	response regulator
EGM51_RS17905	COG1459	type II secretion system
EGM51_RS17910	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EGM51_RS17950	COG4796	Type ii and iii secretion system protein
EGM51_RS17970	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EGM51_RS17980	COG2353	YceI-like domain
EGM51_RS17985	COG0072	phenylalanine-tRNA ligase activity
EGM51_RS18005	COG1199	ATP-dependent helicase activity
EGM51_RS18005	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EGM51_RS18010	COG4935	Belongs to the peptidase S8 family
EGM51_RS18010	COG2234	aminopeptidase activity
EGM51_RS18015	COG2234	aminopeptidase activity
EGM51_RS18020	COG2234	aminopeptidase activity
EGM51_RS18030	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EGM51_RS18030	COG1648	precorrin-2 dehydrogenase activity
EGM51_RS18045	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EGM51_RS18045	COG1333	cytochrome c biogenesis protein
EGM51_RS18050	COG4191	Histidine kinase
EGM51_RS18055	COG2204	response regulator
EGM51_RS18065	COG2983	Belongs to the UPF0260 family