locus-tag	class	description
VSP_RS00005	COG0445	tRNA wobble uridine modification
VSP_RS00015	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VSP_RS00055	COG0508	dehydrogenase complex catalyzes the overall conversion of
VSP_RS00065	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
VSP_RS00075	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
VSP_RS00085	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
VSP_RS00090	COG0571	ribonuclease III activity
VSP_RS00105	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VSP_RS00135	COG0308	aminopeptidase N
VSP_RS00165	COG2072	flavoprotein involved in K transport
VSP_RS00175	COG2144	transferase activity, transferring acyl groups
VSP_RS00180	COG0242	peptide deformylase activity
VSP_RS00185	COG0848	biopolymer transport protein
VSP_RS00190	COG0811	peptide transport
VSP_RS00220	COG1846	Transcriptional regulator
VSP_RS00230	COG1609	Transcriptional regulator
VSP_RS00250	COG0492	ferredoxin-NADP+ reductase activity
VSP_RS00260	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
VSP_RS00260	COG1793	dna ligase
VSP_RS00300	COG2217	Heavy metal translocating P-type atpase
VSP_RS00310	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
VSP_RS00325	COG0820	rRNA (adenine-C2-)-methyltransferase activity
VSP_RS00340	COG0285	dihydrofolate synthase activity
VSP_RS00375	COG2897	thiosulfate sulfurtransferase activity
VSP_RS00390	COG4989	oxidoreductase activity
VSP_RS00395	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VSP_RS00420	COG1056	cytidyltransferase-related domain
VSP_RS00420	COG3172	ATPase kinase involved in NAD metabolism
VSP_RS00500	COG0724	RNA recognition motif
VSP_RS00510	COG1263	PTS System
VSP_RS00510	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VSP_RS00535	COG1335	isochorismatase
VSP_RS00580	COG0640	Transcriptional regulator
VSP_RS00585	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VSP_RS00590	COG0673	inositol 2-dehydrogenase activity
VSP_RS00605	COG1028	Short-chain dehydrogenase reductase Sdr
VSP_RS00615	COG0606	chelatase, subunit chli
VSP_RS00690	COG3119	arylsulfatase activity
VSP_RS00700	COG4566	intracellular signal transduction
VSP_RS00810	COG3507	Belongs to the glycosyl hydrolase 43 family
VSP_RS00810	COG2382	esterase
VSP_RS00810	COG3693	PFAM glycoside hydrolase, family 10
VSP_RS00820	COG0673	inositol 2-dehydrogenase activity
VSP_RS00895	COG0328	RNA-DNA hybrid ribonuclease activity
VSP_RS00935	COG2197	response regulator
VSP_RS00945	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
VSP_RS00985	COG1028	Short-chain dehydrogenase reductase Sdr
VSP_RS00990	COG2207	Transcriptional regulator
VSP_RS01020	COG2201	protein-glutamate methylesterase activity
VSP_RS01025	COG0745	RESPONSE REGULATOR receiver
VSP_RS01035	COG3118	belongs to the thioredoxin family
VSP_RS01065	COG1028	Short-chain dehydrogenase reductase Sdr
VSP_RS01075	COG2807	transmembrane transport
VSP_RS01080	COG0590	tRNA wobble adenosine to inosine editing
VSP_RS01105	COG0745	RESPONSE REGULATOR receiver
VSP_RS01240	COG2197	response regulator
VSP_RS01245	COG4585	Histidine kinase
VSP_RS01295	COG4409	exo-alpha-(2->6)-sialidase activity
VSP_RS01340	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VSP_RS01345	COG1028	Short-chain dehydrogenase reductase Sdr
VSP_RS01360	COG2188	Transcriptional regulator
VSP_RS01365	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
VSP_RS01390	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
VSP_RS01430	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VSP_RS01445	COG0563	adenylate kinase activity
VSP_RS01460	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VSP_RS01465	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VSP_RS01480	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
VSP_RS01485	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
VSP_RS01505	COG0673	inositol 2-dehydrogenase activity
VSP_RS01520	COG1252	NADH dehydrogenase
VSP_RS01525	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
VSP_RS01545	COG2234	aminopeptidase activity
VSP_RS01565	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
VSP_RS01570	COG0066	3-isopropylmalate dehydratase activity
VSP_RS01610	COG3119	arylsulfatase activity
VSP_RS01610	COG3408	Glycogen debranching enzyme
VSP_RS01615	COG3119	arylsulfatase activity
VSP_RS01615	COG3408	Glycogen debranching enzyme
VSP_RS01620	COG1803	Methylglyoxal synthase
VSP_RS01625	COG1716	ATPase activity
VSP_RS01625	COG1131	(ABC) transporter
VSP_RS01625	COG0842	Transport permease protein
VSP_RS01640	COG0793	Belongs to the peptidase S41A family
VSP_RS01670	COG3552	Protein containing von Willebrand factor type A (VWA) domain
VSP_RS01680	COG0714	Associated with various cellular activities
VSP_RS01715	COG4585	Histidine kinase
VSP_RS01720	COG2197	response regulator
VSP_RS01730	COG1335	isochorismatase
VSP_RS01785	COG0676	glucose-6-phosphate 1-epimerase activity
VSP_RS01840	COG2197	response regulator
VSP_RS01860	COG0356	it plays a direct role in the translocation of protons across the membrane
VSP_RS01870	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
VSP_RS01875	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
VSP_RS01880	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
VSP_RS01885	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
VSP_RS01890	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
VSP_RS01910	COG0133	tryptophan synthase activity
VSP_RS01920	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
VSP_RS01925	COG0776	regulation of translation
VSP_RS01940	COG0424	maF-like protein
VSP_RS02010	COG1459	type II secretion system
VSP_RS02090	COG0714	Associated with various cellular activities
VSP_RS02105	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
VSP_RS02110	COG0545	Peptidyl-prolyl cis-trans isomerase
VSP_RS02125	COG1187	pseudouridine synthase activity
VSP_RS02140	COG1368	sulfuric ester hydrolase activity
VSP_RS02180	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
VSP_RS02190	COG0688	phosphatidylethanolamine metabolic process
VSP_RS02220	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VSP_RS02240	COG3162	membrane
VSP_RS02245	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VSP_RS02285	COG0306	phosphate transporter
VSP_RS02330	COG3541	Predicted nucleotidyltransferase
VSP_RS02345	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
VSP_RS02405	COG3842	ATPase activity
VSP_RS02425	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VSP_RS02475	COG1346	cytolysis
VSP_RS02485	COG0583	DNA-binding transcription factor activity
VSP_RS02510	COG4774	siderophore transport
VSP_RS02535	COG1082	Xylose isomerase domain protein TIM barrel
VSP_RS02540	COG0019	diaminopimelate decarboxylase activity
VSP_RS02570	COG1136	(ABC) transporter
VSP_RS02570	COG0577	efflux transmembrane transporter activity
VSP_RS02600	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VSP_RS02605	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
VSP_RS02605	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
VSP_RS02620	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VSP_RS02630	COG2755	lipolytic protein G-D-S-L family
VSP_RS02630	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
VSP_RS02700	COG1691	(AIR) carboxylase
VSP_RS02705	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
VSP_RS02710	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
VSP_RS02750	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
VSP_RS02760	COG0193	aminoacyl-tRNA hydrolase activity
VSP_RS02765	COG0360	Binds together with S18 to 16S ribosomal RNA
VSP_RS02770	COG0629	single-stranded DNA binding
VSP_RS02785	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
VSP_RS02800	COG1349	DNA-binding transcription factor activity
VSP_RS02845	COG3119	arylsulfatase activity
VSP_RS02895	COG1116	anion transmembrane transporter activity
VSP_RS02945	COG3059	membrane
VSP_RS02950	COG2207	Transcriptional regulator
VSP_RS02950	COG1917	Cupin 2, conserved barrel domain protein
VSP_RS02955	COG1741	Belongs to the pirin family
VSP_RS03000	COG0525	valine-tRNA ligase activity
VSP_RS03015	COG2852	Protein conserved in bacteria
VSP_RS03055	COG0488	(ABC) transporter
VSP_RS03090	COG3119	arylsulfatase activity
VSP_RS03105	COG3119	arylsulfatase activity
VSP_RS03140	COG2258	MOSC domain
VSP_RS03160	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VSP_RS03170	COG0697	spore germination
VSP_RS03175	COG1309	transcriptional regulator
VSP_RS03180	COG1028	Short-chain dehydrogenase reductase Sdr
VSP_RS03200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VSP_RS03230	COG0346	lactoylglutathione lyase activity
VSP_RS03235	COG0655	NAD(P)H dehydrogenase (quinone) activity
VSP_RS03255	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
VSP_RS03265	COG2706	6-phosphogluconolactonase activity
VSP_RS03320	COG0431	NADPH-dependent FMN reductase
VSP_RS03325	COG2259	Doxx family
VSP_RS03360	COG3848	Pyruvate phosphate dikinase
VSP_RS03360	COG0574	Belongs to the PEP-utilizing enzyme family
VSP_RS03370	COG1714	RDD family
VSP_RS03400	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
VSP_RS03435	COG0107	imidazoleglycerol-phosphate synthase activity
VSP_RS03440	COG4974	Belongs to the 'phage' integrase family
VSP_RS03445	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VSP_RS03495	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
VSP_RS03510	COG3118	belongs to the thioredoxin family
VSP_RS03550	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
VSP_RS03565	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
VSP_RS03605	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
VSP_RS03615	COG1233	COG1233 Phytoene dehydrogenase and related
VSP_RS03630	COG1132	(ABC) transporter
VSP_RS03635	COG1331	Highly conserved protein containing a thioredoxin domain
VSP_RS03640	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VSP_RS03690	COG0227	Belongs to the bacterial ribosomal protein bL28 family
VSP_RS03700	COG0019	diaminopimelate decarboxylase activity
VSP_RS03715	COG0528	UMP kinase activity
VSP_RS03720	COG0233	cytoplasmic translational termination
VSP_RS03725	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
VSP_RS03760	COG4122	O-methyltransferase activity
VSP_RS03765	COG1028	Short-chain dehydrogenase reductase Sdr
VSP_RS03800	COG1131	(ABC) transporter
VSP_RS03850	COG0175	sulfate reduction
VSP_RS03855	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
VSP_RS03895	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
VSP_RS03900	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
VSP_RS03915	COG0442	prolyl-tRNA aminoacylation
VSP_RS03920	COG0052	Belongs to the universal ribosomal protein uS2 family
VSP_RS03945	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
VSP_RS03965	COG0129	dihydroxy-acid dehydratase activity
VSP_RS04000	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VSP_RS04010	COG3278	Belongs to the heme-copper respiratory oxidase family
VSP_RS04025	COG0348	domain, Protein
VSP_RS04040	COG0589	response to stress
VSP_RS04050	COG2197	response regulator
VSP_RS04060	COG3119	arylsulfatase activity
VSP_RS04070	COG1040	competence protein
VSP_RS04080	COG1136	(ABC) transporter
VSP_RS04085	COG0577	efflux transmembrane transporter activity
VSP_RS04110	COG2814	Major facilitator Superfamily
VSP_RS04135	COG0531	amino acid
VSP_RS04155	COG0277	FAD linked oxidase domain protein
VSP_RS04160	COG1045	serine acetyltransferase
VSP_RS04185	COG0101	tRNA pseudouridine synthase activity
VSP_RS04255	COG2249	NAD(P)H dehydrogenase (quinone) activity
VSP_RS04300	COG0259	pyridoxamine-phosphate oxidase activity
VSP_RS04305	COG0714	Associated with various cellular activities
VSP_RS04365	COG2261	transglycosylase associated protein
VSP_RS04390	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
VSP_RS04410	COG3209	COG3209 Rhs family protein
VSP_RS04460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VSP_RS04465	COG0842	Transport permease protein
VSP_RS04465	COG1129	ABC transporter
VSP_RS04470	COG0842	Transport permease protein
VSP_RS04475	COG0583	DNA-binding transcription factor activity
VSP_RS04480	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
VSP_RS04485	COG3002	Belongs to the UPF0753 family
VSP_RS04490	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
VSP_RS04495	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
VSP_RS04530	COG5433	transposase activity
VSP_RS04715	COG1129	ABC transporter
VSP_RS04790	COG0156	8-amino-7-oxononanoate synthase activity
VSP_RS04810	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
VSP_RS04845	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VSP_RS04855	COG0598	Magnesium transport protein CorA
VSP_RS04860	COG1104	cysteine desulfurase activity
VSP_RS04875	COG1396	sequence-specific DNA binding
VSP_RS04880	COG1063	alcohol dehydrogenase
VSP_RS04885	COG3119	arylsulfatase activity
VSP_RS04910	COG0511	ligase activity, forming carbon-carbon bonds
VSP_RS04915	COG0439	Biotin carboxylase
VSP_RS04935	COG1663	tetraacyldisaccharide 4'-kinase activity
VSP_RS04950	COG4166	transmembrane transport
VSP_RS04965	COG3977	Valine--pyruvate aminotransferase
VSP_RS04975	COG0800	Aldolase
VSP_RS05010	COG0513	Belongs to the DEAD box helicase family
VSP_RS05015	COG1217	gtp-binding protein TYPA
VSP_RS05020	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
VSP_RS05025	COG5433	transposase activity
VSP_RS05075	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
VSP_RS05145	COG1940	carbohydrate kinase activity
VSP_RS05150	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
VSP_RS05170	COG0488	(ABC) transporter
VSP_RS05195	COG0673	inositol 2-dehydrogenase activity
VSP_RS05210	COG2814	Major facilitator Superfamily
VSP_RS05215	COG1940	carbohydrate kinase activity
VSP_RS05230	COG1028	Short-chain dehydrogenase reductase Sdr
VSP_RS05240	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VSP_RS05240	COG2207	Transcriptional regulator
VSP_RS05245	COG2115	Belongs to the xylose isomerase family
VSP_RS05325	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
VSP_RS05335	COG2897	thiosulfate sulfurtransferase activity
VSP_RS05340	COG0745	RESPONSE REGULATOR receiver
VSP_RS05360	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
VSP_RS05380	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
VSP_RS05380	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
VSP_RS05410	COG0714	Associated with various cellular activities
VSP_RS05450	COG0523	cobalamin synthesis protein
VSP_RS05465	COG0396	ATPase activity
VSP_RS05485	COG3645	SOS response
VSP_RS05490	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
VSP_RS05515	COG1136	(ABC) transporter
VSP_RS05530	COG3869	Catalyzes the specific phosphorylation of arginine residues in
VSP_RS05535	COG0542	response to heat
VSP_RS05540	COG1028	Short-chain dehydrogenase reductase Sdr
VSP_RS05545	COG1063	alcohol dehydrogenase
VSP_RS05570	COG3011	Protein conserved in bacteria
VSP_RS05580	COG1505	serine-type exopeptidase activity
VSP_RS05600	COG0587	DNA-directed DNA polymerase activity
VSP_RS05635	COG2197	response regulator
VSP_RS05640	COG3850	Histidine kinase
VSP_RS05685	COG0443	Heat shock 70 kDa protein
VSP_RS05690	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VSP_RS05700	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
VSP_RS05705	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VSP_RS05735	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VSP_RS05775	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
VSP_RS05785	COG2204	response regulator
VSP_RS05810	COG0463	Glycosyl transferase, family 2
VSP_RS05815	COG0438	transferase activity, transferring glycosyl groups
VSP_RS05820	COG0367	asparagine synthase
VSP_RS05825	COG0438	transferase activity, transferring glycosyl groups
VSP_RS05865	COG0438	transferase activity, transferring glycosyl groups
VSP_RS05920	COG2192	nodulation
VSP_RS05925	COG2755	lipolytic protein G-D-S-L family
VSP_RS05925	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
VSP_RS05940	COG3385	transposase activity
VSP_RS05950	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
VSP_RS05955	COG0701	Predicted permease
VSP_RS05965	COG1253	flavin adenine dinucleotide binding
VSP_RS06150	COG0420	3'-5' exonuclease activity
VSP_RS06170	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
VSP_RS06180	COG4208	sulfate ABC transporter
VSP_RS06185	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
VSP_RS06215	COG1959	2 iron, 2 sulfur cluster binding
VSP_RS06265	COG0848	biopolymer transport protein
VSP_RS06270	COG0811	peptide transport
VSP_RS06335	COG0251	oxidation-reduction process
VSP_RS06360	COG1162	GTPase activity
VSP_RS06365	COG2827	Endonuclease containing a URI domain
VSP_RS06390	COG2115	Belongs to the xylose isomerase family
VSP_RS06410	COG2226	methyltransferase
VSP_RS06415	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
VSP_RS06425	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
VSP_RS06490	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
VSP_RS06495	COG0322	excinuclease ABC activity
VSP_RS06580	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
VSP_RS06585	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
VSP_RS06590	COG0583	DNA-binding transcription factor activity
VSP_RS06630	COG0105	UTP biosynthetic process
VSP_RS06770	COG0583	DNA-binding transcription factor activity
VSP_RS06790	COG1063	alcohol dehydrogenase
VSP_RS06795	COG2373	Large extracellular alpha-helical protein
VSP_RS06810	COG4953	penicillin-binding protein 1C
VSP_RS06825	COG1028	Short-chain dehydrogenase reductase Sdr
VSP_RS06855	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
VSP_RS06860	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VSP_RS06870	COG4771	TonB-dependent receptor
VSP_RS06875	COG4191	Histidine kinase
VSP_RS06900	COG0505	Belongs to the CarA family
VSP_RS06910	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
VSP_RS06915	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
VSP_RS06925	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
VSP_RS06930	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VSP_RS06990	COG0828	Belongs to the bacterial ribosomal protein bS21 family
VSP_RS07005	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
VSP_RS07010	COG2205	protein histidine kinase activity
VSP_RS07020	COG2255	four-way junction helicase activity
VSP_RS07025	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VSP_RS07035	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VSP_RS07075	COG5433	transposase activity
VSP_RS07145	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
VSP_RS07155	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VSP_RS07160	COG2814	Major facilitator Superfamily
VSP_RS07175	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
VSP_RS07190	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
VSP_RS07200	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VSP_RS07210	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
VSP_RS07225	COG0798	PFAM Bile acid sodium symporter
VSP_RS07230	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VSP_RS07245	COG1136	(ABC) transporter
VSP_RS07295	COG1169	isochorismate synthase
VSP_RS07300	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
VSP_RS07335	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
VSP_RS07340	COG3119	arylsulfatase activity
VSP_RS07365	COG4335	DNA alkylation repair
VSP_RS07500	COG0438	transferase activity, transferring glycosyl groups
VSP_RS07555	COG3206	protein involved in exopolysaccharide biosynthesis
VSP_RS07555	COG0489	protein tyrosine kinase activity
VSP_RS07575	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VSP_RS07605	COG0714	Associated with various cellular activities
VSP_RS07675	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VSP_RS07680	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VSP_RS07695	COG0230	Belongs to the bacterial ribosomal protein bL34 family
VSP_RS07710	COG0706	membrane insertase activity
VSP_RS07725	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
VSP_RS07740	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VSP_RS07750	COG3119	arylsulfatase activity
VSP_RS07765	COG3174	membrane
VSP_RS07780	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VSP_RS07790	COG1028	Short-chain dehydrogenase reductase Sdr
VSP_RS07800	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VSP_RS07810	COG0232	Belongs to the dGTPase family. Type 2 subfamily
VSP_RS07815	COG0500	methyltransferase
VSP_RS07880	COG3209	COG3209 Rhs family protein
VSP_RS07890	COG2721	sulfolactate sulfo-lyase activity
VSP_RS07920	COG2022	thiamine diphosphate biosynthetic process
VSP_RS07925	COG3253	May function as heme-dependent peroxidase
VSP_RS08000	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VSP_RS08020	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
VSP_RS08025	COG0768	penicillin binding
VSP_RS08055	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
VSP_RS08065	COG4651	solute:proton antiporter activity
VSP_RS08065	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VSP_RS08075	COG3034	peptidoglycan biosynthetic process
VSP_RS08105	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
VSP_RS08170	COG0586	Pfam SNARE associated Golgi protein
VSP_RS08195	COG1090	epimerase
VSP_RS08210	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VSP_RS08250	COG4149	molybdate abc transporter
VSP_RS08295	COG2326	polyphosphate kinase activity
VSP_RS08315	COG1216	Glycosyl transferase, family 2
VSP_RS08315	COG0438	transferase activity, transferring glycosyl groups
VSP_RS08320	COG1858	cytochrome C peroxidase
VSP_RS08340	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
VSP_RS08345	COG0590	tRNA wobble adenosine to inosine editing
VSP_RS08355	COG0714	Associated with various cellular activities
VSP_RS08365	COG4555	ABC transporter
VSP_RS08420	COG0673	inositol 2-dehydrogenase activity
VSP_RS08450	COG1082	Xylose isomerase domain protein TIM barrel
VSP_RS08460	COG0346	lactoylglutathione lyase activity
VSP_RS08465	COG1070	Carbohydrate kinase
VSP_RS08475	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
VSP_RS08500	COG1388	LysM domain
VSP_RS08500	COG3103	Sh3 type 3 domain protein
VSP_RS08500	COG0791	NLP P60 protein
VSP_RS08505	COG2309	aminopeptidase activity
VSP_RS08510	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
VSP_RS08520	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
VSP_RS08525	COG0254	rRNA binding
VSP_RS08565	COG1482	cell wall glycoprotein biosynthetic process
VSP_RS08590	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
VSP_RS08595	COG1247	-acetyltransferase
VSP_RS08605	COG1028	Short-chain dehydrogenase reductase Sdr
VSP_RS08615	COG1126	abc transporter atp-binding protein
VSP_RS08620	COG0765	amino acid transport
VSP_RS08625	COG2247	cell wall binding repeat
VSP_RS08625	COG0860	N-Acetylmuramoyl-L-alanine amidase
VSP_RS08650	COG2308	Evidence 4 Homologs of previously reported genes of
VSP_RS08660	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
VSP_RS08740	COG0583	DNA-binding transcription factor activity
VSP_RS08785	COG0423	glycine-tRNA ligase activity
VSP_RS08795	COG2957	Belongs to the agmatine deiminase family
VSP_RS09105	COG1450	Type ii and iii secretion system protein
VSP_RS09140	COG1450	Type ii and iii secretion system protein
VSP_RS09180	COG3239	Fatty acid desaturase
VSP_RS09225	COG2197	response regulator
VSP_RS09245	COG3385	transposase activity
VSP_RS09275	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VSP_RS09310	COG0693	protein deglycase activity
VSP_RS09325	COG1902	pentaerythritol trinitrate reductase activity
VSP_RS09335	COG1064	alcohol dehydrogenase
VSP_RS09340	COG2814	Major facilitator Superfamily
VSP_RS09345	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
VSP_RS09365	COG0516	GMP reductase activity
VSP_RS09365	COG0517	IMP dehydrogenase activity
VSP_RS09415	COG0072	phenylalanine-tRNA ligase activity
VSP_RS09425	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
VSP_RS09430	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
VSP_RS09435	COG0291	Belongs to the bacterial ribosomal protein bL35 family
VSP_RS09440	COG4191	Histidine kinase
VSP_RS09445	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
VSP_RS09450	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
VSP_RS09500	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
VSP_RS09560	COG0513	Belongs to the DEAD box helicase family
VSP_RS09565	COG0363	glucosamine-6-phosphate deaminase activity
VSP_RS09570	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
VSP_RS09580	COG0673	inositol 2-dehydrogenase activity
VSP_RS09635	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
VSP_RS09640	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VSP_RS09640	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VSP_RS09650	COG1368	sulfuric ester hydrolase activity
VSP_RS09660	COG0657	acetylesterase activity
VSP_RS09660	COG2755	lipolytic protein G-D-S-L family
VSP_RS09690	COG0493	'glutamate synthase
VSP_RS09690	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
VSP_RS09695	COG0077	Prephenate dehydratase
VSP_RS09695	COG1605	Chorismate mutase
VSP_RS09705	COG1376	ErfK ybiS ycfS ynhG family protein
VSP_RS09710	COG1404	Belongs to the peptidase S8 family
VSP_RS09730	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
VSP_RS09735	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
VSP_RS09760	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
VSP_RS09765	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
VSP_RS09780	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
VSP_RS10085	COG0667	Aldo Keto reductase
VSP_RS10090	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VSP_RS10110	COG1028	Short-chain dehydrogenase reductase Sdr
VSP_RS10145	COG0459	protein refolding
VSP_RS10150	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
VSP_RS10155	COG0443	Heat shock 70 kDa protein
VSP_RS10225	COG1830	Aldolase
VSP_RS10240	COG0604	alcohol dehydrogenase
VSP_RS10245	COG1028	Short-chain dehydrogenase reductase Sdr
VSP_RS10280	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
VSP_RS10305	COG4651	solute:proton antiporter activity
VSP_RS10305	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VSP_RS10410	COG1183	phosphatidylcholine synthase activity
VSP_RS10430	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
VSP_RS10505	COG0322	excinuclease ABC activity
VSP_RS10535	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
VSP_RS10560	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
VSP_RS10590	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
VSP_RS10615	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
VSP_RS10620	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
VSP_RS10625	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VSP_RS10630	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
VSP_RS10635	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
VSP_RS10665	COG0445	tRNA wobble uridine modification
VSP_RS10670	COG1063	alcohol dehydrogenase
VSP_RS10700	COG2059	Chromate
VSP_RS10715	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
VSP_RS10720	COG0047	phosphoribosylformylglycinamidine synthase activity
VSP_RS10810	COG0151	Belongs to the GarS family
VSP_RS10820	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
VSP_RS10825	COG0540	Belongs to the ATCase OTCase family
VSP_RS10830	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
VSP_RS10850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VSP_RS10860	COG2197	response regulator
VSP_RS10910	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VSP_RS10930	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VSP_RS10995	COG1176	ABC-type spermidine putrescine transport system, permease component I
VSP_RS11000	COG0202	RNA polymerase activity
VSP_RS11005	COG0203	ribosomal protein L17
VSP_RS11075	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
VSP_RS11100	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
VSP_RS11105	COG1612	heme a metabolic process
VSP_RS11110	COG0109	protoheme IX farnesyltransferase activity
VSP_RS11120	COG2322	membrane
VSP_RS11125	COG0681	Belongs to the peptidase S26 family
VSP_RS11130	COG0481	GTPase activity
VSP_RS11145	COG0783	Belongs to the Dps family
VSP_RS11155	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VSP_RS11175	COG2814	Major facilitator Superfamily
VSP_RS11255	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VSP_RS11265	COG0471	metal ion transport
VSP_RS11265	COG0490	domain, Protein
VSP_RS11305	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VSP_RS11315	COG0644	oxidoreductase
VSP_RS11365	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
VSP_RS11430	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
VSP_RS11455	COG1597	lipid kinase activity
VSP_RS11510	COG3285	dna ligase
VSP_RS11510	COG1793	dna ligase
VSP_RS11550	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VSP_RS11555	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
VSP_RS11565	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
VSP_RS11575	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VSP_RS11630	COG0720	synthase
VSP_RS11685	COG0488	(ABC) transporter
VSP_RS11705	COG3158	transport of potassium into the cell
VSP_RS11710	COG3158	transport of potassium into the cell
VSP_RS11715	COG0138	bifunctional purine biosynthesis protein purh
VSP_RS11720	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
VSP_RS11725	COG0736	holo-[acyl-carrier-protein] synthase activity
VSP_RS11735	COG0753	catalase activity
VSP_RS11760	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
VSP_RS11765	COG0830	nickel cation binding
VSP_RS11775	COG0804	urea catabolic process
VSP_RS11780	COG0832	Belongs to the urease beta subunit family
VSP_RS11785	COG0831	urea catabolic process
VSP_RS11820	COG3385	transposase activity
VSP_RS11830	COG0626	cystathionine gamma-synthase activity
VSP_RS11835	COG0657	acetylesterase activity
VSP_RS11855	COG0557	exoribonuclease II activity
VSP_RS11930	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VSP_RS11945	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
VSP_RS11950	COG2890	protein-(glutamine-N5) methyltransferase activity
VSP_RS11955	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VSP_RS11980	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
VSP_RS11990	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VSP_RS11995	COG0693	protein deglycase activity
VSP_RS12020	COG0284	orotidine-5'-phosphate decarboxylase activity
VSP_RS12025	COG0039	L-malate dehydrogenase activity
VSP_RS12050	COG3385	transposase activity
VSP_RS12055	COG0039	L-malate dehydrogenase activity
VSP_RS12075	COG2814	Major facilitator Superfamily
VSP_RS12090	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
VSP_RS12095	COG0315	cyclic pyranopterin monophosphate synthase activity
VSP_RS12100	COG0521	Mo-molybdopterin cofactor biosynthetic process
VSP_RS12110	COG0432	Pfam Uncharacterised protein family UPF0047
VSP_RS12115	COG0270	DNA (cytosine-5-)-methyltransferase activity
VSP_RS12135	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
VSP_RS12140	COG5002	protein histidine kinase activity
VSP_RS12140	COG3850	Histidine kinase
VSP_RS12150	COG0577	efflux transmembrane transporter activity
VSP_RS12150	COG1136	(ABC) transporter
VSP_RS12155	COG0577	efflux transmembrane transporter activity
VSP_RS12155	COG1136	(ABC) transporter
VSP_RS12170	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
VSP_RS12220	COG1929	Belongs to the glycerate kinase type-1 family
VSP_RS12305	COG5433	transposase activity
VSP_RS12390	COG0653	protein targeting
VSP_RS12405	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
VSP_RS12415	COG4589	Belongs to the CDS family
VSP_RS12430	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VSP_RS12430	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VSP_RS12440	COG0640	Transcriptional regulator
VSP_RS12465	COG3618	amidohydrolase
VSP_RS12480	COG5564	TIM-barrel signal transduction protein
VSP_RS12495	COG0523	cobalamin synthesis protein
VSP_RS12505	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
VSP_RS12540	COG2363	Small membrane protein
VSP_RS12595	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
VSP_RS12605	COG1132	(ABC) transporter
VSP_RS12610	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
VSP_RS12685	COG0038	chloride channel
VSP_RS12690	COG0436	Aminotransferase
VSP_RS12700	COG2323	membrane
VSP_RS12725	COG2885	chlorophyll binding
VSP_RS12725	COG3047	cAMP biosynthetic process
VSP_RS12785	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VSP_RS12805	COG4221	oxidoreductase activity
VSP_RS12835	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
VSP_RS12845	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VSP_RS12865	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
VSP_RS12875	COG2211	Major facilitator Superfamily
VSP_RS12890	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VSP_RS12945	COG2207	Transcriptional regulator
VSP_RS12945	COG1609	Transcriptional regulator
VSP_RS12955	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VSP_RS13005	COG2066	Belongs to the glutaminase family
VSP_RS13005	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
VSP_RS13010	COG1119	ATPase activity
VSP_RS13025	COG2814	Major facilitator Superfamily
VSP_RS13030	COG0277	FAD linked oxidase domain protein
VSP_RS13035	COG0247	lactate metabolic process
VSP_RS13050	COG1058	Belongs to the CinA family
VSP_RS13050	COG1546	Belongs to the CinA family
VSP_RS13090	COG4774	siderophore transport
VSP_RS13100	COG5433	transposase activity
VSP_RS13165	COG0842	Transport permease protein
VSP_RS13165	COG1131	(ABC) transporter
VSP_RS13165	COG1716	ATPase activity
VSP_RS13185	COG5002	protein histidine kinase activity
VSP_RS13210	COG1368	sulfuric ester hydrolase activity
VSP_RS13235	COG3385	transposase activity
VSP_RS13250	COG2877	3-deoxy-8-phosphooctulonate synthase activity
VSP_RS13265	COG1137	ATPase activity
VSP_RS13270	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VSP_RS13280	COG0859	PFAM glycosyl transferase family 9
VSP_RS13300	COG1131	(ABC) transporter
VSP_RS13305	COG1254	Belongs to the acylphosphatase family
VSP_RS13315	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
VSP_RS13320	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VSP_RS13350	COG3209	COG3209 Rhs family protein
VSP_RS13375	COG3385	transposase activity
VSP_RS13430	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
VSP_RS13455	COG1509	lysine 2,3-aminomutase activity
VSP_RS13465	COG3119	arylsulfatase activity
VSP_RS13470	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
VSP_RS13480	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
VSP_RS13490	COG1091	dTDP-4-dehydrorhamnose reductase activity
VSP_RS13510	COG1250	3-hydroxyacyl-CoA dehydrogenase
VSP_RS13515	COG3281	Trehalose synthase
VSP_RS13520	COG0154	amidase activity
VSP_RS13530	COG0367	asparagine synthase
VSP_RS13535	COG0604	alcohol dehydrogenase
VSP_RS13535	COG1028	Short-chain dehydrogenase reductase Sdr
VSP_RS13535	COG3321	synthase
VSP_RS13565	COG1136	(ABC) transporter
VSP_RS13570	COG1136	(ABC) transporter
VSP_RS13570	COG4591	ABC-type transport system involved in lipoprotein release permease component
VSP_RS13585	COG4297	protein containing double-stranded beta helix domain
VSP_RS13630	COG3685	Protein conserved in bacteria
VSP_RS13635	COG0673	inositol 2-dehydrogenase activity
VSP_RS13680	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
VSP_RS13715	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VSP_RS13720	COG1459	type II secretion system
VSP_RS13750	COG1450	Type ii and iii secretion system protein
VSP_RS13770	COG3156	type II secretion system protein K
VSP_RS13780	COG1178	ABC-type Fe3 transport system permease component
VSP_RS13790	COG3842	ATPase activity
VSP_RS13865	COG3459	Glycosyltransferase 36 associated
VSP_RS13870	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VSP_RS13875	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
VSP_RS13905	COG1216	Glycosyl transferase, family 2
VSP_RS13985	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
VSP_RS14025	COG0135	phosphoribosylanthranilate isomerase activity
VSP_RS14050	COG2226	methyltransferase
VSP_RS14055	COG0628	permease
VSP_RS14065	COG1609	Transcriptional regulator
VSP_RS14070	COG0788	formyltetrahydrofolate deformylase activity
VSP_RS14095	COG3119	arylsulfatase activity
VSP_RS14100	COG3119	arylsulfatase activity
VSP_RS14165	COG0602	queuosine metabolic process
VSP_RS14185	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VSP_RS14190	COG3119	arylsulfatase activity
VSP_RS14235	COG2188	Transcriptional regulator
VSP_RS14290	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VSP_RS14290	COG0551	DNA topoisomerase type I activity
VSP_RS14295	COG2814	Major facilitator Superfamily
VSP_RS14320	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
VSP_RS14330	COG0489	protein tyrosine kinase activity
VSP_RS14335	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
VSP_RS14350	COG0501	Belongs to the peptidase M48B family
VSP_RS14355	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VSP_RS14400	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VSP_RS14415	COG3685	Protein conserved in bacteria
VSP_RS14460	COG0523	cobalamin synthesis protein
VSP_RS14470	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
VSP_RS14475	COG0523	cobalamin synthesis protein
VSP_RS14495	COG0642	Histidine kinase
VSP_RS14500	COG0745	RESPONSE REGULATOR receiver
VSP_RS14520	COG3119	arylsulfatase activity
VSP_RS14530	COG1846	Transcriptional regulator
VSP_RS14575	COG1674	ftsk spoiiie
VSP_RS14595	COG0504	CTP synthase activity
VSP_RS14600	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
VSP_RS14620	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VSP_RS14630	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VSP_RS14630	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VSP_RS14635	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
VSP_RS14660	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VSP_RS14665	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
VSP_RS14670	COG2003	Belongs to the UPF0758 family
VSP_RS14685	COG0142	geranyltranstransferase activity
VSP_RS14700	COG2154	pterin-4-alpha-carbinolamine dehydratase
VSP_RS14710	COG1686	Belongs to the peptidase S11 family
VSP_RS14715	COG0205	6-phosphofructokinase activity
VSP_RS14720	COG1522	sequence-specific DNA binding
VSP_RS14725	COG0436	Aminotransferase
VSP_RS14750	COG2204	response regulator
VSP_RS14755	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
VSP_RS14755	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VSP_RS14765	COG0297	glycogen (starch) synthase activity
VSP_RS14770	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
VSP_RS14775	COG1082	Xylose isomerase domain protein TIM barrel
VSP_RS14840	COG3385	transposase activity
VSP_RS14845	COG2267	carboxylic ester hydrolase activity
VSP_RS14865	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
VSP_RS14870	COG0326	Molecular chaperone. Has ATPase activity
VSP_RS14885	COG0018	arginyl-trna synthetase
VSP_RS14920	COG3385	transposase activity
VSP_RS14925	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VSP_RS14955	COG0673	inositol 2-dehydrogenase activity
VSP_RS15035	COG0154	amidase activity
VSP_RS15080	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VSP_RS15100	COG0297	glycogen (starch) synthase activity
VSP_RS15120	COG2223	nitrite transmembrane transporter activity
VSP_RS15175	COG0288	reversible hydration of carbon dioxide
VSP_RS15195	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VSP_RS15225	COG0825	malonyl-CoA metabolic process
VSP_RS15240	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
VSP_RS15255	COG0673	inositol 2-dehydrogenase activity
VSP_RS15260	COG1312	Catalyzes the dehydration of D-mannonate
VSP_RS15265	COG1917	Cupin 2, conserved barrel domain protein
VSP_RS15265	COG2207	Transcriptional regulator
VSP_RS15285	COG2197	response regulator
VSP_RS15290	COG4251	negative regulation of phosphorylation
VSP_RS15305	COG4191	Histidine kinase
VSP_RS15305	COG2205	protein histidine kinase activity
VSP_RS15305	COG0745	RESPONSE REGULATOR receiver
VSP_RS15320	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
VSP_RS15320	COG3264	Mechanosensitive ion channel
VSP_RS15340	COG1028	Short-chain dehydrogenase reductase Sdr
VSP_RS15350	COG0191	fructose-bisphosphate aldolase activity
VSP_RS15370	COG1702	phosphate starvation-inducible protein PhoH
VSP_RS15400	COG0546	phosphoglycolate phosphatase activity
VSP_RS15405	COG0494	nUDIX hydrolase
VSP_RS15455	COG3385	transposase activity
VSP_RS15480	COG0820	rRNA (adenine-C2-)-methyltransferase activity
VSP_RS15485	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
VSP_RS15605	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
VSP_RS15640	COG4864	UPF0365 protein
VSP_RS15650	COG0842	Transport permease protein
VSP_RS15650	COG1129	ABC transporter
VSP_RS15655	COG3265	gluconokinase activity
VSP_RS15690	COG5433	transposase activity
VSP_RS15710	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
VSP_RS15740	COG0515	serine threonine protein kinase
VSP_RS15740	COG2815	serine threonine protein kinase
VSP_RS15745	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
VSP_RS15750	COG1595	DNA-templated transcription, initiation
VSP_RS15785	COG3209	COG3209 Rhs family protein
VSP_RS15785	COG4104	PAAR repeat-containing protein
VSP_RS15865	COG2197	response regulator
VSP_RS15905	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VSP_RS15915	COG3119	arylsulfatase activity
VSP_RS15960	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
VSP_RS15965	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
VSP_RS16005	COG0439	Biotin carboxylase
VSP_RS16010	COG3665	Urea carboxylase-associated protein
VSP_RS16030	COG2771	luxR family
VSP_RS16035	COG0174	glutamine synthetase
VSP_RS16045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VSP_RS16055	COG2814	Major facilitator Superfamily
VSP_RS16060	COG0671	phosphoesterase, PA-phosphatase related
VSP_RS16080	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
VSP_RS16085	COG0113	porphobilinogen synthase activity
VSP_RS16090	COG0215	cysteine-tRNA ligase activity
VSP_RS16095	COG1054	Belongs to the UPF0176 family
VSP_RS16115	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
VSP_RS16145	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
VSP_RS16165	COG2197	response regulator
VSP_RS16195	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
VSP_RS16215	COG2084	Dehydrogenase
VSP_RS16220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VSP_RS16225	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VSP_RS16340	COG0683	leucine binding
VSP_RS16345	COG0210	DNA helicase
VSP_RS16355	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
VSP_RS16360	COG0792	nuclease activity
VSP_RS16410	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
VSP_RS16495	COG4112	unkown
VSP_RS16560	COG3119	arylsulfatase activity
VSP_RS16565	COG1970	mechanosensitive ion channel activity
VSP_RS16580	COG3119	arylsulfatase activity
VSP_RS16585	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VSP_RS16590	COG0583	DNA-binding transcription factor activity
VSP_RS16595	COG2738	Putative neutral zinc metallopeptidase
VSP_RS16620	COG1904	glucuronate isomerase
VSP_RS16635	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
VSP_RS16640	COG1185	polyribonucleotide nucleotidyltransferase activity
VSP_RS16645	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
VSP_RS16695	COG0134	indole-3-glycerol-phosphate synthase activity
VSP_RS16720	COG2204	response regulator
VSP_RS16770	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VSP_RS16810	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
VSP_RS16825	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VSP_RS16825	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VSP_RS16830	COG1696	Membrane protein involved in D-alanine export
VSP_RS16845	COG0552	protein localization to endoplasmic reticulum
VSP_RS16850	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VSP_RS16875	COG0473	3-isopropylmalate dehydrogenase activity
VSP_RS16890	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
VSP_RS16895	COG0058	SHG alpha-glucan phosphorylase activity
VSP_RS16910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VSP_RS16950	COG1566	PFAM secretion protein HlyD family protein
VSP_RS16955	COG1309	transcriptional regulator
VSP_RS16975	COG1538	Outer membrane efflux protein
VSP_RS17065	COG0714	Associated with various cellular activities
VSP_RS17100	COG0004	ammonium transporteR
VSP_RS17120	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
VSP_RS17135	COG1764	response to oxidative stress
VSP_RS17140	COG1940	carbohydrate kinase activity
VSP_RS17145	COG0248	Ppx GppA phosphatase
VSP_RS17175	COG4191	Histidine kinase
VSP_RS17180	COG4566	intracellular signal transduction
VSP_RS17185	COG2204	response regulator
VSP_RS17220	COG1131	(ABC) transporter
VSP_RS17240	COG0116	Belongs to the methyltransferase superfamily
VSP_RS17240	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VSP_RS17255	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
VSP_RS17260	COG0537	adenosine 5'-monophosphoramidase activity
VSP_RS17265	COG1966	Carbon starvation protein
VSP_RS17275	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
VSP_RS17305	COG0714	Associated with various cellular activities
VSP_RS17395	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VSP_RS17475	COG2376	Dihydroxyacetone kinase
VSP_RS17485	COG0022	dehydrogenase e1 component
VSP_RS17485	COG0508	dehydrogenase complex catalyzes the overall conversion of
VSP_RS17495	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VSP_RS17515	COG0659	secondary active sulfate transmembrane transporter activity
VSP_RS17585	COG1172	Belongs to the binding-protein-dependent transport system permease family
VSP_RS17590	COG1129	ABC transporter
VSP_RS17635	COG0673	inositol 2-dehydrogenase activity
VSP_RS17650	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VSP_RS17660	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
VSP_RS17680	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
VSP_RS17685	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
VSP_RS17695	COG0416	fatty acid biosynthetic process
VSP_RS17700	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VSP_RS17735	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
VSP_RS17750	COG0768	penicillin binding
VSP_RS17765	COG1077	Cell shape determining protein MreB Mrl
VSP_RS17770	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
VSP_RS17795	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VSP_RS17800	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VSP_RS17845	COG2226	methyltransferase
VSP_RS17895	COG1994	Peptidase M50
VSP_RS17910	COG0795	lipopolysaccharide-transporting ATPase activity
VSP_RS17925	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
VSP_RS17935	COG1573	uracil-dna glycosylase
VSP_RS17940	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
VSP_RS17975	COG0546	phosphoglycolate phosphatase activity
VSP_RS18010	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
VSP_RS18020	COG1166	arginine decarboxylase activity
VSP_RS18025	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
VSP_RS18030	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VSP_RS18060	COG3385	transposase activity
VSP_RS18120	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
VSP_RS18125	COG0483	inositol monophosphate 1-phosphatase activity
VSP_RS18130	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
VSP_RS18160	COG1393	Belongs to the ArsC family
VSP_RS18180	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VSP_RS18205	COG1802	Transcriptional regulator
VSP_RS18260	COG0438	transferase activity, transferring glycosyl groups
VSP_RS18265	COG0335	large ribosomal subunit rRNA binding
VSP_RS18270	COG0501	Belongs to the peptidase M48B family
VSP_RS18275	COG0017	Asparaginyl-tRNA synthetase
VSP_RS18305	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VSP_RS18310	COG0492	ferredoxin-NADP+ reductase activity
VSP_RS18320	COG2162	N-hydroxyarylamine O-acetyltransferase activity
VSP_RS18350	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VSP_RS18360	COG1459	type II secretion system
VSP_RS18365	COG2165	general secretion pathway protein
VSP_RS18425	COG0673	inositol 2-dehydrogenase activity
VSP_RS18440	COG2258	MOSC domain
VSP_RS18465	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
VSP_RS18470	COG0849	cell division
VSP_RS18480	COG1181	Belongs to the D-alanine--D-alanine ligase family
VSP_RS18505	COG0196	riboflavin kinase activity
VSP_RS18510	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
VSP_RS18515	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
VSP_RS18525	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
VSP_RS18530	COG0195	Participates in both transcription termination and antitermination
VSP_RS18700	COG1131	(ABC) transporter
VSP_RS18850	COG5002	protein histidine kinase activity
VSP_RS18870	COG2135	peptidase activity
VSP_RS18880	COG4974	Belongs to the 'phage' integrase family
VSP_RS18890	COG2610	gluconate transmembrane transporter activity
VSP_RS18940	COG0714	Associated with various cellular activities
VSP_RS18965	COG4591	ABC-type transport system involved in lipoprotein release permease component
VSP_RS18965	COG1136	(ABC) transporter
VSP_RS18985	COG0768	penicillin binding
VSP_RS19045	COG0217	transcriptional regulatory protein
VSP_RS19120	COG1216	Glycosyl transferase, family 2
VSP_RS19135	COG0297	glycogen (starch) synthase activity
VSP_RS19140	COG0367	asparagine synthase
VSP_RS19150	COG2095	MarC family integral membrane protein
VSP_RS19155	COG0259	pyridoxamine-phosphate oxidase activity
VSP_RS19160	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
VSP_RS19185	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
VSP_RS19190	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VSP_RS19200	COG0470	DNA polymerase III
VSP_RS19215	COG0179	Fumarylacetoacetate (FAA) hydrolase
VSP_RS19220	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
VSP_RS19220	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VSP_RS19240	COG2818	Glycosylase
VSP_RS19270	COG4585	Histidine kinase
VSP_RS19330	COG4585	Histidine kinase
VSP_RS19365	COG4941	Belongs to the sigma-70 factor family
VSP_RS19405	COG0673	inositol 2-dehydrogenase activity
VSP_RS19415	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VSP_RS19435	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
VSP_RS19455	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VSP_RS19460	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
VSP_RS19470	COG0768	penicillin binding
VSP_RS19490	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VSP_RS19560	COG0574	Belongs to the PEP-utilizing enzyme family
VSP_RS19560	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
VSP_RS19610	COG1595	DNA-templated transcription, initiation
VSP_RS19625	COG4993	Dehydrogenase
VSP_RS19640	COG1570	exodeoxyribonuclease VII activity
VSP_RS19645	COG3279	Response regulator of the LytR AlgR family
VSP_RS19665	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VSP_RS19670	COG1136	(ABC) transporter
VSP_RS19675	COG0577	efflux transmembrane transporter activity
VSP_RS19685	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
VSP_RS19695	COG4821	SIS domain
VSP_RS19715	COG0149	triose-phosphate isomerase activity
VSP_RS19720	COG0126	phosphoglycerate kinase activity
VSP_RS19745	COG1595	DNA-templated transcription, initiation
VSP_RS19835	COG0640	Transcriptional regulator
VSP_RS19905	COG5433	transposase activity
VSP_RS19975	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
VSP_RS19985	COG0495	leucyl-tRNA aminoacylation
VSP_RS20010	COG0316	Belongs to the HesB IscA family
VSP_RS20015	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
VSP_RS20015	COG3170	Tfp pilus assembly protein FimV
VSP_RS20035	COG1051	belongs to the nudix hydrolase family
VSP_RS20050	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VSP_RS20060	COG1388	LysM domain
VSP_RS20060	COG0791	NLP P60 protein
VSP_RS20075	COG0567	Dehydrogenase, E1 component
VSP_RS20080	COG1131	(ABC) transporter
VSP_RS20110	COG3422	double-strand break repair
VSP_RS20145	COG1846	Transcriptional regulator
VSP_RS20150	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
VSP_RS20150	COG0617	tRNA 3'-terminal CCA addition
VSP_RS20150	COG0517	IMP dehydrogenase activity
VSP_RS20180	COG0166	Belongs to the GPI family
VSP_RS20225	COG0583	DNA-binding transcription factor activity
VSP_RS20230	COG0513	Belongs to the DEAD box helicase family
VSP_RS20235	COG0673	inositol 2-dehydrogenase activity
VSP_RS20590	COG1475	DNA binding
VSP_RS20660	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
VSP_RS20680	COG0592	DNA-directed DNA polymerase activity
VSP_RS20715	COG3220	belongs to the UPF0276 family
VSP_RS20775	COG0640	Transcriptional regulator
VSP_RS20785	COG0542	response to heat
VSP_RS20895	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VSP_RS20900	COG3001	Fructosamine kinase
VSP_RS20905	COG1837	Belongs to the UPF0109 family
VSP_RS20910	COG0228	four-way junction DNA binding
VSP_RS21010	COG1372	Participates in initiation and elongation during chromosome replication
VSP_RS21010	COG0305	Participates in initiation and elongation during chromosome replication
VSP_RS21035	COG0582	viral genome integration into host DNA
VSP_RS21090	COG0300	oxidoreductase activity
VSP_RS21095	COG1064	alcohol dehydrogenase
VSP_RS21135	COG3795	YCII-related domain
VSP_RS21160	COG1575	Belongs to the MenA family. Type 1 subfamily
VSP_RS21175	COG0482	sulfurtransferase activity
VSP_RS21190	COG0494	nUDIX hydrolase
VSP_RS21200	COG0305	Participates in initiation and elongation during chromosome replication
VSP_RS21205	COG1472	Belongs to the glycosyl hydrolase 3 family
VSP_RS21225	COG3386	PFAM SMP-30 Gluconolaconase
VSP_RS21230	COG1027	Aspartate ammonia-lyase
VSP_RS21240	COG4260	virion core protein, lumpy skin disease virus
VSP_RS21260	COG4603	Belongs to the binding-protein-dependent transport system permease family
VSP_RS21270	COG3845	ABC transporter
VSP_RS21300	COG0673	inositol 2-dehydrogenase activity
VSP_RS21310	COG2824	Alkylphosphonate utilization operon protein PhnA
VSP_RS21325	COG0174	glutamine synthetase
VSP_RS21330	COG1496	oxidoreductase activity
VSP_RS21390	COG1028	Short-chain dehydrogenase reductase Sdr
VSP_RS21410	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
VSP_RS21415	COG0187	DNA topoisomerase II activity
VSP_RS21420	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VSP_RS21435	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
VSP_RS21450	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
VSP_RS21455	COG0114	fumarate hydratase activity
VSP_RS21475	COG2080	2 iron, 2 sulfur cluster binding
VSP_RS21475	COG1529	Aldehyde oxidase and xanthine dehydrogenase
VSP_RS21480	COG2252	PERMEase
VSP_RS21525	COG2351	hydroxyisourate hydrolase activity
VSP_RS21580	COG1053	succinate dehydrogenase
VSP_RS21585	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
VSP_RS21590	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
VSP_RS21635	COG0776	regulation of translation
VSP_RS21670	COG0584	glycerophosphoryl diester phosphodiesterase
VSP_RS21750	COG2207	Transcriptional regulator
VSP_RS21790	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VSP_RS21860	COG0346	lactoylglutathione lyase activity
VSP_RS21935	COG0415	Belongs to the DNA photolyase family
VSP_RS21965	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
VSP_RS21975	COG3842	ATPase activity
VSP_RS22005	COG5433	transposase activity
VSP_RS22030	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
VSP_RS22085	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VSP_RS22095	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
VSP_RS22105	COG0671	phosphoesterase, PA-phosphatase related
VSP_RS22150	COG0800	Aldolase
VSP_RS22155	COG0363	glucosamine-6-phosphate deaminase activity
VSP_RS22180	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
VSP_RS22200	COG0564	pseudouridine synthase activity
VSP_RS22210	COG0673	inositol 2-dehydrogenase activity
VSP_RS22215	COG2345	Transcriptional regulator
VSP_RS22235	COG1643	Atp-dependent helicase
VSP_RS22240	COG1609	Transcriptional regulator
VSP_RS22295	COG0205	6-phosphofructokinase activity
VSP_RS22300	COG0456	acetyltransferase
VSP_RS22310	COG1487	ribonuclease activity
VSP_RS22315	COG1304	FMN binding
VSP_RS22340	COG2010	Cytochrome c
VSP_RS22390	COG3385	transposase activity
VSP_RS22485	COG0024	Methionine aminopeptidase
VSP_RS22490	COG0201	protein transport
VSP_RS22495	COG0200	Binds to the 23S rRNA
VSP_RS22500	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
VSP_RS22505	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
VSP_RS22510	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
VSP_RS22515	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
VSP_RS22520	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
VSP_RS22525	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
VSP_RS22530	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
VSP_RS22535	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
VSP_RS22545	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
VSP_RS22550	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
VSP_RS22555	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
VSP_RS22565	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
VSP_RS22570	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
VSP_RS22575	COG0089	rRNA binding
VSP_RS22580	COG0088	Forms part of the polypeptide exit tunnel
VSP_RS22585	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
VSP_RS22590	COG0051	transcription antitermination factor activity, RNA binding
VSP_RS22595	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VSP_RS22600	COG0049	tRNA binding
VSP_RS22605	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
VSP_RS22615	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VSP_RS22625	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
VSP_RS22680	COG3275	phosphorelay sensor kinase activity
VSP_RS22685	COG0167	dihydroorotate dehydrogenase activity
VSP_RS22710	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
VSP_RS22740	COG1649	PFAM Uncharacterised BCR, COG1649
VSP_RS22765	COG0815	Transfers the fatty acyl group on membrane lipoproteins
VSP_RS22770	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
VSP_RS22770	COG0758	DNA mediated transformation
VSP_RS22775	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
VSP_RS22790	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VSP_RS22795	COG3842	ATPase activity
VSP_RS22850	COG3119	arylsulfatase activity
VSP_RS22915	COG2261	transglycosylase associated protein
VSP_RS23005	COG3795	YCII-related domain
VSP_RS23010	COG4941	Belongs to the sigma-70 factor family
VSP_RS23090	COG0435	Glutathione S-transferase
VSP_RS23120	COG2197	response regulator
VSP_RS23165	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
VSP_RS23170	COG1468	defense response to virus
VSP_RS23170	COG1518	maintenance of DNA repeat elements
VSP_RS23195	COG1203	CRISPR-associated helicase, Cas3
VSP_RS23210	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VSP_RS23220	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
VSP_RS23225	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
VSP_RS23230	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
VSP_RS23265	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VSP_RS23265	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
VSP_RS23275	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
VSP_RS23285	COG4178	(ABC) transporter
VSP_RS23335	COG3119	arylsulfatase activity
VSP_RS23350	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
VSP_RS23430	COG0518	GMP synthase (glutamine-hydrolyzing) activity
VSP_RS23430	COG0519	Catalyzes the synthesis of GMP from XMP
VSP_RS23435	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
VSP_RS23450	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
VSP_RS23455	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
VSP_RS23475	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
VSP_RS23485	COG5002	protein histidine kinase activity
VSP_RS23515	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VSP_RS23545	COG1475	DNA binding
VSP_RS23565	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VSP_RS23625	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
VSP_RS23645	COG0583	DNA-binding transcription factor activity
VSP_RS23650	COG0826	peptidase U32
VSP_RS23655	COG0513	Belongs to the DEAD box helicase family
VSP_RS23665	COG1196	nuclear chromosome segregation
VSP_RS23690	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VSP_RS23705	COG1116	anion transmembrane transporter activity
VSP_RS23725	COG2223	nitrite transmembrane transporter activity
VSP_RS23730	COG0515	serine threonine protein kinase
VSP_RS23735	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VSP_RS23740	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VSP_RS23750	COG0243	molybdopterin cofactor binding
VSP_RS23760	COG0667	Aldo Keto reductase
VSP_RS23790	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VSP_RS23795	COG0772	Belongs to the SEDS family
VSP_RS23820	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VSP_RS23870	COG2967	ApaG domain
VSP_RS23880	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
VSP_RS23910	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VSP_RS23920	COG2378	regulation of single-species biofilm formation
VSP_RS23925	COG0489	protein tyrosine kinase activity
VSP_RS23960	COG2205	protein histidine kinase activity
VSP_RS24030	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
VSP_RS24040	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VSP_RS24045	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
VSP_RS24055	COG0583	DNA-binding transcription factor activity
VSP_RS24060	COG2226	methyltransferase
VSP_RS24085	COG0803	Belongs to the bacterial solute-binding protein 9 family
VSP_RS24095	COG1121	(ABC) transporter
VSP_RS24100	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VSP_RS24200	COG4245	von Willebrand factor, type A
VSP_RS24205	COG2304	oxidoreductase activity
VSP_RS24235	COG1358	cellular component organization or biogenesis
VSP_RS24275	COG3119	arylsulfatase activity
VSP_RS24320	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
VSP_RS24320	COG1796	DNA polymerase
VSP_RS24325	COG0028	Belongs to the TPP enzyme family
VSP_RS24340	COG4251	negative regulation of phosphorylation
VSP_RS24345	COG4191	Histidine kinase
VSP_RS24390	COG0784	Response regulator, receiver
VSP_RS24395	COG0745	RESPONSE REGULATOR receiver
VSP_RS24400	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VSP_RS24410	COG3654	unkown
VSP_RS24420	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
VSP_RS24425	COG0861	Integral membrane protein TerC family
VSP_RS24430	COG2954	triphosphatase activity
VSP_RS24440	COG1215	transferase activity, transferring glycosyl groups
VSP_RS24450	COG0515	serine threonine protein kinase
VSP_RS24450	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VSP_RS24465	COG5433	transposase activity
VSP_RS24470	COG0463	Glycosyl transferase, family 2
VSP_RS24485	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VSP_RS24490	COG0673	inositol 2-dehydrogenase activity
VSP_RS24495	COG1210	Utp--glucose-1-phosphate uridylyltransferase
VSP_RS24505	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
VSP_RS24520	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
VSP_RS24780	COG1408	metallophosphoesterase
VSP_RS24795	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
VSP_RS24800	COG0673	inositol 2-dehydrogenase activity
VSP_RS24810	COG1388	LysM domain
VSP_RS24810	COG0791	NLP P60 protein
VSP_RS24815	COG1028	Short-chain dehydrogenase reductase Sdr
VSP_RS24830	COG0084	hydrolase, TatD family'
VSP_RS24835	COG1262	PFAM Formylglycine-generating sulfatase enzyme
VSP_RS24870	COG1872	DUF167
VSP_RS24880	COG0275	rRNA processing
VSP_RS24915	COG0318	PFAM AMP-dependent synthetase and ligase
VSP_RS24920	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VSP_RS24935	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VSP_RS24950	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VSP_RS24990	COG0515	serine threonine protein kinase
VSP_RS24990	COG1262	PFAM Formylglycine-generating sulfatase enzyme
VSP_RS24995	COG0673	inositol 2-dehydrogenase activity
VSP_RS25010	COG2226	methyltransferase
VSP_RS25020	COG0490	domain, Protein
VSP_RS25020	COG0471	metal ion transport
VSP_RS25040	COG1459	type II secretion system
VSP_RS25045	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VSP_RS25050	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VSP_RS25070	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
VSP_RS25075	COG0583	DNA-binding transcription factor activity
VSP_RS25095	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
VSP_RS25150	COG1215	transferase activity, transferring glycosyl groups
VSP_RS25160	COG0805	protein transport
VSP_RS25170	COG0165	Argininosuccinate lyase
VSP_RS25180	COG2885	chlorophyll binding
VSP_RS25220	COG2197	response regulator
VSP_RS25225	COG4585	Histidine kinase
VSP_RS25240	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VSP_RS25240	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
VSP_RS25245	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VSP_RS25315	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VSP_RS25390	COG2814	Major facilitator Superfamily
VSP_RS25415	COG0438	transferase activity, transferring glycosyl groups
VSP_RS25430	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
VSP_RS25430	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
VSP_RS25450	COG0745	RESPONSE REGULATOR receiver
VSP_RS25455	COG5002	protein histidine kinase activity
VSP_RS25465	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
VSP_RS25475	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
VSP_RS25500	COG0217	transcriptional regulatory protein
VSP_RS25510	COG1469	GTP cyclohydrolase I activity
VSP_RS25515	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
VSP_RS25520	COG0267	Belongs to the bacterial ribosomal protein bL33 family
VSP_RS25540	COG0640	Transcriptional regulator
VSP_RS25550	COG0573	inorganic phosphate transmembrane transporter activity
VSP_RS25570	COG1605	Chorismate mutase
VSP_RS25570	COG0077	Prephenate dehydratase
VSP_RS25575	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VSP_RS25580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VSP_RS25585	COG1013	pyruvate-flavodoxin oxidoreductase activity
VSP_RS25590	COG0674	pyruvate-flavodoxin oxidoreductase activity
VSP_RS25590	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
VSP_RS25610	COG3119	arylsulfatase activity
VSP_RS25665	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
VSP_RS25700	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
VSP_RS25705	COG1678	Uncharacterized ACR, COG1678
VSP_RS25710	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VSP_RS25710	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VSP_RS25730	COG0778	Nitroreductase
VSP_RS25735	COG0372	Belongs to the citrate synthase family
VSP_RS25750	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
VSP_RS25760	COG0045	succinate-CoA ligase (ADP-forming) activity
VSP_RS25815	COG1131	(ABC) transporter
VSP_RS25820	COG0842	Transport permease protein
VSP_RS25870	COG1640	4-alpha-glucanotransferase
VSP_RS25900	COG1309	transcriptional regulator
VSP_RS25910	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
VSP_RS25915	COG4176	ABC-type proline glycine betaine transport system permease component
VSP_RS25930	COG0725	ABC transporter, periplasmic molybdate-binding protein
VSP_RS25960	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
VSP_RS25970	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
VSP_RS26005	COG4774	siderophore transport
VSP_RS26010	COG3128	pkhd-type hydroxylase
VSP_RS26020	COG0527	aspartate kinase activity
VSP_RS26035	COG0142	geranyltranstransferase activity
VSP_RS26085	COG1610	YqeY-like protein
VSP_RS26100	COG0261	This protein binds to 23S rRNA in the presence of protein L20
VSP_RS26105	COG0211	Belongs to the bacterial ribosomal protein bL27 family
VSP_RS26115	COG3040	lipid binding
VSP_RS26150	COG0307	riboflavin synthase, alpha
VSP_RS26160	COG0492	ferredoxin-NADP+ reductase activity
VSP_RS26185	COG1007	ATP synthesis coupled electron transport
VSP_RS26190	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VSP_RS26195	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
VSP_RS26200	COG0713	ATP synthesis coupled electron transport
VSP_RS26215	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
VSP_RS26220	COG1034	ATP synthesis coupled electron transport
VSP_RS26240	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
VSP_RS26250	COG0649	NAD binding
VSP_RS26265	COG3795	YCII-related domain
VSP_RS26290	COG1760	l-serine dehydratase
VSP_RS26295	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VSP_RS26300	COG0006	proline dipeptidase activity
VSP_RS26320	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VSP_RS26325	COG2207	Transcriptional regulator
VSP_RS26335	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VSP_RS26340	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
VSP_RS26355	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
VSP_RS26375	COG0438	transferase activity, transferring glycosyl groups
VSP_RS26385	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VSP_RS26420	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
VSP_RS26425	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
VSP_RS26435	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
VSP_RS26495	COG1132	(ABC) transporter
VSP_RS26500	COG1132	(ABC) transporter
VSP_RS26565	COG1595	DNA-templated transcription, initiation
VSP_RS26580	COG2115	Belongs to the xylose isomerase family
VSP_RS26600	COG1030	water channel activity
VSP_RS26610	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
VSP_RS26645	COG1199	ATP-dependent helicase activity
VSP_RS26655	COG1968	undecaprenyl-diphosphatase activity
VSP_RS26685	COG5433	transposase activity
VSP_RS26710	COG3385	transposase activity
VSP_RS26755	COG3344	reverse transcriptase
VSP_RS26780	COG1073	alpha beta
VSP_RS26785	COG3119	arylsulfatase activity
VSP_RS26795	COG2197	response regulator
VSP_RS26805	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
VSP_RS26810	COG4608	Belongs to the ABC transporter superfamily
VSP_RS26815	COG0444	Belongs to the ABC transporter superfamily
VSP_RS26840	COG0601	transmembrane transport
VSP_RS26845	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VSP_RS26860	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
VSP_RS26865	COG0857	belongs to the CobB CobQ family
VSP_RS26865	COG0280	phosphate acetyltransferase
VSP_RS26905	COG0726	polysaccharide deacetylase
VSP_RS26975	COG0129	dihydroxy-acid dehydratase activity
VSP_RS26980	COG1028	Short-chain dehydrogenase reductase Sdr
VSP_RS27005	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VSP_RS27005	COG1017	nitric oxide dioxygenase activity
VSP_RS27010	COG1959	2 iron, 2 sulfur cluster binding
VSP_RS27015	COG1028	Short-chain dehydrogenase reductase Sdr
VSP_RS27055	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
VSP_RS27060	COG0085	RNA polymerase activity
VSP_RS27065	COG0222	ribosome binding
VSP_RS27070	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
VSP_RS27075	COG0081	regulation of translation
VSP_RS27080	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
VSP_RS27085	COG0250	Participates in transcription elongation, termination and antitermination
VSP_RS27100	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VSP_RS27120	COG3119	arylsulfatase activity
VSP_RS27145	COG0811	peptide transport
VSP_RS27180	COG0137	argininosuccinate synthase activity
VSP_RS27220	COG2207	Transcriptional regulator
VSP_RS27220	COG1609	Transcriptional regulator
VSP_RS27280	COG2207	Transcriptional regulator
VSP_RS27615	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
VSP_RS28060	COG0316	Belongs to the HesB IscA family
VSP_RS28070	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
VSP_RS28100	COG0110	maltose O-acetyltransferase activity
VSP_RS28135	COG1132	(ABC) transporter
VSP_RS28145	COG0352	thiamine-phosphate diphosphorylase activity
VSP_RS28160	COG0802	atpase or kinase
VSP_RS28185	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VSP_RS28215	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
VSP_RS28220	COG2319	Wd-40 repeat
VSP_RS28220	COG4249	Peptidase C14 caspase catalytic subunit p20
VSP_RS28225	COG0823	Involved in the tonB-independent uptake of proteins
VSP_RS28395	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
VSP_RS28395	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
VSP_RS28425	COG1136	(ABC) transporter
VSP_RS28430	COG1136	(ABC) transporter
VSP_RS28430	COG0577	efflux transmembrane transporter activity
VSP_RS28485	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
VSP_RS28495	COG1131	(ABC) transporter
VSP_RS28515	COG0009	L-threonylcarbamoyladenylate synthase
VSP_RS28555	COG1131	(ABC) transporter
VSP_RS28575	COG0069	glutamate synthase activity
VSP_RS28575	COG0067	glutamate synthase
VSP_RS28575	COG0070	glutamate synthase
VSP_RS28590	COG0469	pyruvate kinase activity
VSP_RS28610	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
VSP_RS28625	COG1692	metallophosphoesterase
VSP_RS28640	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
VSP_RS28650	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
VSP_RS28690	COG2815	serine threonine protein kinase
VSP_RS28690	COG0515	serine threonine protein kinase
VSP_RS28760	COG0366	Alpha amylase catalytic
VSP_RS28770	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
VSP_RS28790	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VSP_RS28800	COG0463	Glycosyl transferase, family 2
VSP_RS28820	COG0531	amino acid
VSP_RS28845	COG3119	arylsulfatase activity
VSP_RS28860	COG1100	Small GTP-binding protein
VSP_RS28865	COG4771	TonB-dependent receptor
VSP_RS28870	COG1429	ligase activity, forming nitrogen-metal bonds
VSP_RS28915	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
VSP_RS28925	COG1597	lipid kinase activity
VSP_RS28930	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
VSP_RS28960	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VSP_RS28965	COG0601	transmembrane transport
VSP_RS28990	COG0354	folic acid binding
VSP_RS29020	COG0745	RESPONSE REGULATOR receiver
VSP_RS29025	COG2205	protein histidine kinase activity
VSP_RS29050	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
VSP_RS29070	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
VSP_RS29105	COG0730	response to heat
VSP_RS29125	COG3622	Belongs to the hyi family
VSP_RS29140	COG0673	inositol 2-dehydrogenase activity
VSP_RS29155	COG1561	YicC-like family, N-terminal region
VSP_RS29175	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
VSP_RS29220	COG0202	RNA polymerase activity
VSP_RS29230	COG3046	protein related to deoxyribodipyrimidine photolyase
VSP_RS29235	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
VSP_RS29240	COG0300	oxidoreductase activity
VSP_RS29270	COG0512	Glutamine amidotransferase of anthranilate synthase
VSP_RS29280	COG0811	peptide transport
VSP_RS29285	COG0848	biopolymer transport protein
VSP_RS29290	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
VSP_RS29295	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
VSP_RS29310	COG1127	ABC transporter
VSP_RS29345	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
VSP_RS29380	COG1525	nuclease
VSP_RS29410	COG0275	rRNA processing
VSP_RS29460	COG0438	transferase activity, transferring glycosyl groups
VSP_RS29475	COG1596	polysaccharide export
VSP_RS29495	COG1045	serine acetyltransferase
VSP_RS29505	COG0438	transferase activity, transferring glycosyl groups
VSP_RS29540	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VSP_RS29580	COG0640	Transcriptional regulator
VSP_RS29585	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VSP_RS29590	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VSP_RS29625	COG2217	Heavy metal translocating P-type atpase
VSP_RS29645	COG4178	(ABC) transporter
VSP_RS30005	COG3119	arylsulfatase activity
VSP_RS30040	COG3119	arylsulfatase activity
VSP_RS30085	COG3119	arylsulfatase activity
VSP_RS30125	COG0647	UMP catabolic process
VSP_RS30140	COG1012	belongs to the aldehyde dehydrogenase family
VSP_RS30150	COG2271	Major facilitator Superfamily
VSP_RS30290	COG3344	reverse transcriptase
VSP_RS30330	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VSP_RS30365	COG2165	general secretion pathway protein
VSP_RS30470	COG0180	Tryptophanyl-tRNA synthetase
VSP_RS30490	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
VSP_RS30545	COG4585	Histidine kinase
VSP_RS30550	COG2197	response regulator
VSP_RS30560	COG0714	Associated with various cellular activities
VSP_RS30650	COG2197	response regulator
VSP_RS30695	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VSP_RS30855	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
VSP_RS30900	COG2205	protein histidine kinase activity
VSP_RS30905	COG0745	RESPONSE REGULATOR receiver
VSP_RS30910	COG4636	protein conserved in cyanobacteria
VSP_RS30940	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VSP_RS30960	COG0142	geranyltranstransferase activity
VSP_RS30970	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
VSP_RS30975	COG0497	DNA recombination
VSP_RS30995	COG0583	DNA-binding transcription factor activity
VSP_RS31000	COG0129	dihydroxy-acid dehydratase activity
VSP_RS31005	COG0006	proline dipeptidase activity
VSP_RS31050	COG0386	Belongs to the glutathione peroxidase family
VSP_RS31070	COG1201	RNA secondary structure unwinding
VSP_RS31120	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VSP_RS31190	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
VSP_RS31250	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
VSP_RS31285	COG5433	transposase activity
VSP_RS31305	COG3209	COG3209 Rhs family protein
VSP_RS31440	COG0204	Acyl-transferase
VSP_RS31440	COG0318	PFAM AMP-dependent synthetase and ligase
VSP_RS31445	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
VSP_RS31465	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
VSP_RS31580	COG1136	(ABC) transporter
VSP_RS31590	COG4974	Belongs to the 'phage' integrase family
VSP_RS31680	COG4792	protein secretion
VSP_RS31690	COG4794	Type iii secretion
VSP_RS31695	COG4790	Type iii secretion
VSP_RS31700	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
VSP_RS31810	COG0457	Tetratricopeptide repeat
VSP_RS31895	COG2995	paraquat-inducible protein a
VSP_RS31900	COG2995	paraquat-inducible protein a
VSP_RS31905	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VSP_RS31905	COG3008	intermembrane lipid transfer
VSP_RS31945	COG0714	Associated with various cellular activities
VSP_RS31980	COG3956	TIGRFAM MazG family protein
VSP_RS31995	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
VSP_RS31995	COG0321	lipoyl(octanoyl) transferase activity
VSP_RS32010	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VSP_RS32015	COG0514	ATP-dependent DNA helicase (RecQ)
VSP_RS32040	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
VSP_RS32045	COG0012	GTP binding
VSP_RS32055	COG3852	Histidine kinase
VSP_RS32060	COG1324	tolerance protein
VSP_RS32080	COG0154	amidase activity
VSP_RS32090	COG1028	Short-chain dehydrogenase reductase Sdr
VSP_RS32105	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VSP_RS32120	COG0632	four-way junction helicase activity
VSP_RS32130	COG5002	protein histidine kinase activity
VSP_RS32130	COG3850	Histidine kinase
VSP_RS32160	COG2949	membrane
VSP_RS32165	COG1490	D-aminoacyl-tRNA deacylase activity
VSP_RS32190	COG0438	transferase activity, transferring glycosyl groups
VSP_RS32195	COG0514	ATP-dependent DNA helicase (RecQ)
VSP_RS32200	COG2346	COG2346, Truncated hemoglobins
VSP_RS32215	COG2962	Rard protein
VSP_RS32220	COG1193	negative regulation of DNA recombination
VSP_RS32240	COG0746	molybdenum cofactor guanylyltransferase activity
VSP_RS32265	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VSP_RS32310	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
VSP_RS32315	COG1459	type II secretion system
VSP_RS32320	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VSP_RS32320	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VSP_RS32335	COG0740	serine-type endopeptidase activity
VSP_RS32350	COG1959	2 iron, 2 sulfur cluster binding
VSP_RS32355	COG0220	tRNA (guanine-N7-)-methyltransferase activity
VSP_RS32360	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
VSP_RS32370	COG1301	dicarboxylic acid transport
VSP_RS32375	COG0471	metal ion transport
VSP_RS32435	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
VSP_RS32440	COG0698	ribose 5-phosphate isomerase
VSP_RS32450	COG0131	Imidazoleglycerol-phosphate dehydratase
VSP_RS32450	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VSP_RS32485	COG0544	peptidyl-prolyl cis-trans isomerase activity
VSP_RS32495	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
VSP_RS32500	COG1940	carbohydrate kinase activity
VSP_RS32540	COG0708	Exodeoxyribonuclease III
VSP_RS32575	COG1090	epimerase
VSP_RS32595	COG4650	regulator
VSP_RS32650	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
VSP_RS32680	COG0673	inositol 2-dehydrogenase activity
VSP_RS32760	COG2207	Transcriptional regulator
VSP_RS32770	COG0673	inositol 2-dehydrogenase activity
VSP_RS32785	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
VSP_RS32795	COG0405	Gamma-glutamyltransferase
VSP_RS32805	COG3385	transposase activity
VSP_RS32815	COG0515	serine threonine protein kinase
VSP_RS32815	COG2815	serine threonine protein kinase
VSP_RS32820	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VSP_RS32820	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VSP_RS32830	COG0343	queuine tRNA-ribosyltransferase activity
VSP_RS32835	COG3119	arylsulfatase activity
VSP_RS32885	COG0556	nucleotide-excision repair
VSP_RS32900	COG0561	phosphatase activity
VSP_RS32905	COG0438	transferase activity, transferring glycosyl groups
VSP_RS32915	COG0445	tRNA wobble uridine modification
VSP_RS32935	COG1620	l-lactate permease
VSP_RS32970	COG2198	Histidine kinase
VSP_RS32970	COG0784	Response regulator, receiver
VSP_RS32970	COG2205	protein histidine kinase activity
VSP_RS33000	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VSP_RS33005	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VSP_RS33010	COG1121	(ABC) transporter
VSP_RS33015	COG0803	Belongs to the bacterial solute-binding protein 9 family
VSP_RS33095	COG0022	dehydrogenase e1 component
VSP_RS33095	COG0508	dehydrogenase complex catalyzes the overall conversion of
VSP_RS33100	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
VSP_RS33130	COG1649	PFAM Uncharacterised BCR, COG1649
VSP_RS33135	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VSP_RS33175	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VSP_RS33180	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
VSP_RS33180	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
VSP_RS33190	COG3424	synthase
VSP_RS33205	COG0529	Catalyzes the synthesis of activated sulfate
VSP_RS33260	COG1309	transcriptional regulator
VSP_RS33370	COG1376	ErfK ybiS ycfS ynhG family protein
VSP_RS33375	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
VSP_RS33390	COG0431	NADPH-dependent FMN reductase
VSP_RS33395	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
VSP_RS33405	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
VSP_RS33415	COG2205	protein histidine kinase activity
VSP_RS33415	COG0784	Response regulator, receiver
VSP_RS33415	COG5002	protein histidine kinase activity
VSP_RS33430	COG2805	Type II/IV secretion system protein
VSP_RS33440	COG2010	Cytochrome c
VSP_RS33460	COG3132	Protein of unknown function, DUF480
VSP_RS33475	COG1442	glycosyl transferase family 8
VSP_RS33475	COG1216	Glycosyl transferase, family 2
VSP_RS33485	COG2805	Type II/IV secretion system protein
VSP_RS33500	COG4264	IucA IucC family
VSP_RS33520	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VSP_RS33550	COG1606	tRNA processing
VSP_RS33565	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
VSP_RS33615	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VSP_RS33630	COG3119	arylsulfatase activity
VSP_RS33635	COG3119	arylsulfatase activity
VSP_RS33640	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VSP_RS33650	COG2814	Major facilitator Superfamily
VSP_RS33690	COG0484	heat shock protein binding
VSP_RS33705	COG0583	DNA-binding transcription factor activity
VSP_RS33745	COG2124	cytochrome p450
VSP_RS33755	COG0662	Cupin 2, conserved barrel domain protein
VSP_RS33755	COG2207	Transcriptional regulator
VSP_RS33780	COG3344	reverse transcriptase
VSP_RS33800	COG4191	Histidine kinase
VSP_RS33820	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
VSP_RS33840	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
VSP_RS33915	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VSP_RS33950	COG3698	Phosphodiester glycosidase
VSP_RS33955	COG0438	transferase activity, transferring glycosyl groups
VSP_RS33980	COG4181	ATPase activity
VSP_RS33995	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VSP_RS34010	COG0719	Fe-S assembly protein
VSP_RS34110	COG0444	Belongs to the ABC transporter superfamily
VSP_RS34130	COG0509	glycine decarboxylation via glycine cleavage system
VSP_RS34155	COG2304	oxidoreductase activity
VSP_RS34190	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
VSP_RS34215	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VSP_RS34220	COG0653	protein targeting
VSP_RS34225	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VSP_RS34230	COG1943	Transposase
VSP_RS34240	COG1716	ATPase activity
VSP_RS34240	COG1131	(ABC) transporter
VSP_RS34240	COG0842	Transport permease protein
VSP_RS34245	COG2204	response regulator
VSP_RS34280	COG0330	HflC and HflK could
VSP_RS34410	COG0438	transferase activity, transferring glycosyl groups
VSP_RS34435	COG0811	peptide transport
VSP_RS34445	COG0594	ribonuclease P activity
VSP_RS34450	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VSP_RS34505	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VSP_RS34520	COG0739	heme binding
VSP_RS34550	COG2197	response regulator
VSP_RS34585	COG0860	N-Acetylmuramoyl-L-alanine amidase
VSP_RS34595	COG4980	gas vesicle protein
VSP_RS34595	COG1674	ftsk spoiiie
VSP_RS34610	COG3942	CHAP domain
VSP_RS34610	COG1388	LysM domain
VSP_RS34675	COG4804	nuclease activity
VSP_RS34720	COG0071	Belongs to the small heat shock protein (HSP20) family
VSP_RS34740	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
VSP_RS34755	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
VSP_RS34790	COG0738	Major facilitator superfamily
VSP_RS34820	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VSP_RS34875	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
VSP_RS34885	COG0745	RESPONSE REGULATOR receiver
VSP_RS34895	COG1595	DNA-templated transcription, initiation
VSP_RS34905	COG0437	4 iron, 4 sulfur cluster binding
VSP_RS34970	COG3408	Glycogen debranching enzyme
VSP_RS34970	COG3119	arylsulfatase activity
VSP_RS34980	COG1562	ergosterol biosynthetic process
VSP_RS34985	COG0475	glutathione-regulated potassium exporter activity
VSP_RS34990	COG0429	hydrolase of the alpha beta-hydrolase fold
VSP_RS35020	COG0584	glycerophosphoryl diester phosphodiesterase
VSP_RS35025	COG3738	Protein conserved in bacteria
VSP_RS35030	COG3119	arylsulfatase activity
VSP_RS35080	COG0697	spore germination
VSP_RS35095	COG3070	regulator of competence-specific genes
VSP_RS35105	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VSP_RS35115	COG0463	Glycosyl transferase, family 2
VSP_RS35120	COG4948	Mandelate Racemase Muconate Lactonizing
VSP_RS35180	COG2943	transferase activity, transferring hexosyl groups
VSP_RS35190	COG0367	asparagine synthase
VSP_RS35205	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
VSP_RS35210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VSP_RS35220	COG1012	belongs to the aldehyde dehydrogenase family
VSP_RS35250	COG3876	Protein conserved in bacteria
VSP_RS35255	COG0799	negative regulation of ribosome biogenesis
VSP_RS35420	COG1595	DNA-templated transcription, initiation
VSP_RS35435	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VSP_RS35440	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VSP_RS35440	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VSP_RS35445	COG0438	transferase activity, transferring glycosyl groups
VSP_RS35445	COG1216	Glycosyl transferase, family 2
VSP_RS35485	COG3119	arylsulfatase activity
VSP_RS35620	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
VSP_RS35625	COG1480	7TM receptor with intracellular HD hydrolase
VSP_RS35685	COG1074	ATP-dependent DNA helicase activity
VSP_RS35700	COG1028	Short-chain dehydrogenase reductase Sdr
VSP_RS35755	COG5002	protein histidine kinase activity
VSP_RS35790	COG0631	protein serine/threonine phosphatase activity
VSP_RS35830	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
VSP_RS35880	COG1192	Involved in chromosome partitioning
VSP_RS35900	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VSP_RS35925	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
VSP_RS35960	COG0726	polysaccharide deacetylase
VSP_RS35965	COG0628	permease
VSP_RS35980	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
VSP_RS36025	COG2267	carboxylic ester hydrolase activity
VSP_RS36030	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
VSP_RS36110	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
VSP_RS36140	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
VSP_RS36175	COG3119	arylsulfatase activity
VSP_RS36180	COG1183	phosphatidylcholine synthase activity
VSP_RS36215	COG1250	3-hydroxyacyl-CoA dehydrogenase
VSP_RS36215	COG1024	Enoyl-CoA hydratase
VSP_RS36235	COG1643	Atp-dependent helicase
VSP_RS36270	COG2197	response regulator
VSP_RS36295	COG0772	Belongs to the SEDS family
VSP_RS36305	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
VSP_RS36320	COG0657	acetylesterase activity
VSP_RS36380	COG0534	Mate efflux family protein
VSP_RS36495	COG0287	Prephenate dehydrogenase
VSP_RS36500	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
VSP_RS36570	COG0359	binds to the 23S rRNA
VSP_RS36605	COG1253	flavin adenine dinucleotide binding
VSP_RS36610	COG4566	intracellular signal transduction
VSP_RS36615	COG0583	DNA-binding transcription factor activity
VSP_RS36620	COG3608	succinylglutamate desuccinylase aspartoacylase
VSP_RS36620	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
VSP_RS36745	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
VSP_RS36765	COG4991	sh3 domain protein
VSP_RS36765	COG0860	N-Acetylmuramoyl-L-alanine amidase
VSP_RS36765	COG3103	Sh3 type 3 domain protein
VSP_RS36795	COG0076	glutamate decarboxylase activity
VSP_RS36805	COG0255	Belongs to the universal ribosomal protein uL29 family
VSP_RS36815	COG1160	GTP binding
VSP_RS36880	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
VSP_RS36885	COG0724	RNA recognition motif
VSP_RS36905	COG0038	chloride channel
VSP_RS36930	COG0784	Response regulator, receiver
VSP_RS36930	COG2205	protein histidine kinase activity
VSP_RS36940	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
VSP_RS36995	COG0612	Peptidase, M16
VSP_RS37015	COG0811	peptide transport
VSP_RS37020	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
VSP_RS37050	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VSP_RS37075	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VSP_RS37125	COG0583	DNA-binding transcription factor activity
VSP_RS37130	COG1116	anion transmembrane transporter activity
VSP_RS37130	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VSP_RS37135	COG1116	anion transmembrane transporter activity
VSP_RS37135	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VSP_RS37140	COG0437	4 iron, 4 sulfur cluster binding
VSP_RS37155	COG0772	Belongs to the SEDS family
VSP_RS37175	COG0351	phosphomethylpyrimidine kinase
VSP_RS37330	COG1686	Belongs to the peptidase S11 family
VSP_RS37370	COG1519	Transferase
VSP_RS37375	COG0742	ribosomal rna small subunit methyltransferase
VSP_RS37385	COG1262	PFAM Formylglycine-generating sulfatase enzyme
VSP_RS37390	COG0438	transferase activity, transferring glycosyl groups
VSP_RS37410	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VSP_RS37450	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VSP_RS37460	COG3585	molybdate ion transport
VSP_RS37460	COG2005	Transcriptional regulator
VSP_RS37495	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
VSP_RS37520	COG0542	response to heat
VSP_RS37535	COG0181	hydroxymethylbilane synthase activity
VSP_RS37540	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
VSP_RS37540	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
VSP_RS37735	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
VSP_RS37735	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
VSP_RS37765	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
VSP_RS37770	COG0616	signal peptide processing
VSP_RS37775	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
VSP_RS37815	COG0646	methionine synthase
VSP_RS37815	COG1410	methionine synthase
VSP_RS37840	COG0724	RNA recognition motif
VSP_RS37935	COG0793	Belongs to the peptidase S41A family
VSP_RS37945	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VSP_RS37950	COG4956	integral membrane protein (PIN domain superfamily)
VSP_RS37965	COG1051	belongs to the nudix hydrolase family
VSP_RS37985	COG2197	response regulator
VSP_RS38050	COG2949	membrane
VSP_RS38075	COG2207	Transcriptional regulator
VSP_RS38075	COG1609	Transcriptional regulator
VSP_RS38080	COG3119	arylsulfatase activity
VSP_RS38100	COG1063	alcohol dehydrogenase
VSP_RS38150	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VSP_RS38180	COG1609	Transcriptional regulator
VSP_RS38180	COG2207	Transcriptional regulator
VSP_RS38210	COG3119	arylsulfatase activity
VSP_RS38235	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
VSP_RS38255	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VSP_RS38295	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
VSP_RS38300	COG0484	heat shock protein binding
VSP_RS38410	COG4791	protein targeting
VSP_RS38460	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
VSP_RS38475	COG1376	ErfK ybiS ycfS ynhG family protein
VSP_RS38480	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
VSP_RS38485	COG1943	Transposase
VSP_RS38495	COG0656	L-ascorbic acid biosynthetic process
VSP_RS38515	COG3481	metal-dependent phosphohydrolase, HD sub domain
VSP_RS38525	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
VSP_RS38575	COG0583	DNA-binding transcription factor activity
VSP_RS38595	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VSP_RS38605	COG4804	nuclease activity
VSP_RS38625	COG2094	Belongs to the DNA glycosylase MPG family
VSP_RS38665	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
VSP_RS38690	COG1215	transferase activity, transferring glycosyl groups
VSP_RS38710	COG4191	Histidine kinase
VSP_RS38710	COG0745	RESPONSE REGULATOR receiver
VSP_RS38710	COG2205	protein histidine kinase activity
VSP_RS38725	COG1802	Transcriptional regulator
VSP_RS38740	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VSP_RS38745	COG2132	Multicopper oxidase
VSP_RS38750	COG4970	Tfp pilus assembly protein FimT
VSP_RS38790	COG2165	general secretion pathway protein
VSP_RS38820	COG2226	methyltransferase
VSP_RS38835	COG2186	Transcriptional regulator
VSP_RS38850	COG0488	(ABC) transporter
VSP_RS38855	COG0488	(ABC) transporter
VSP_RS38875	COG4968	Prepilin-type N-terminal cleavage methylation domain
VSP_RS38890	COG1917	Cupin 2, conserved barrel domain protein
VSP_RS38890	COG2207	Transcriptional regulator
VSP_RS38935	COG0336	Belongs to the RNA methyltransferase TrmD family
VSP_RS38945	COG1686	Belongs to the peptidase S11 family
VSP_RS38950	COG0710	3-dehydroquinate dehydratase activity
VSP_RS38955	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VSP_RS39025	COG0640	Transcriptional regulator
VSP_RS39035	COG1215	transferase activity, transferring glycosyl groups
VSP_RS39040	COG1215	transferase activity, transferring glycosyl groups
VSP_RS39050	COG1442	glycosyl transferase family 8
VSP_RS39050	COG1216	Glycosyl transferase, family 2
VSP_RS39060	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VSP_RS39080	COG4977	sequence-specific DNA binding
VSP_RS39080	COG1917	Cupin 2, conserved barrel domain protein
VSP_RS39085	COG5444	nuclease activity
VSP_RS39095	COG0573	inorganic phosphate transmembrane transporter activity
VSP_RS39100	COG0671	phosphoesterase, PA-phosphatase related
VSP_RS39110	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
VSP_RS39120	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VSP_RS39125	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VSP_RS39140	COG1187	pseudouridine synthase activity
VSP_RS39150	COG1475	DNA binding
VSP_RS39170	COG3275	phosphorelay sensor kinase activity
VSP_RS39190	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
VSP_RS39195	COG2205	protein histidine kinase activity
VSP_RS39195	COG0784	Response regulator, receiver
VSP_RS39205	COG4676	Protein conserved in bacteria
VSP_RS39210	COG2815	serine threonine protein kinase
VSP_RS39210	COG0515	serine threonine protein kinase
VSP_RS39235	COG0575	Belongs to the CDS family
VSP_RS39240	COG4585	Histidine kinase
VSP_RS39265	COG1845	cytochrome c oxidase, subunit III
VSP_RS39285	COG2815	serine threonine protein kinase
VSP_RS39285	COG0515	serine threonine protein kinase
VSP_RS39320	COG2514	catechol 2,3-dioxygenase activity
VSP_RS39340	COG5002	protein histidine kinase activity
VSP_RS39350	COG0724	RNA recognition motif
VSP_RS39360	COG2755	lipolytic protein G-D-S-L family
VSP_RS39375	COG0584	glycerophosphoryl diester phosphodiesterase
VSP_RS39395	COG1215	transferase activity, transferring glycosyl groups
VSP_RS39450	COG2165	general secretion pathway protein
VSP_RS39475	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
VSP_RS39490	COG0784	Response regulator, receiver
VSP_RS39490	COG5002	protein histidine kinase activity
VSP_RS39520	COG1215	transferase activity, transferring glycosyl groups
VSP_RS39535	COG3852	Histidine kinase
VSP_RS39540	COG1864	DNA RNA non-specific endonuclease
VSP_RS39540	COG3591	Belongs to the peptidase S1B family
VSP_RS39545	COG2771	luxR family
VSP_RS39560	COG0583	DNA-binding transcription factor activity
VSP_RS39570	COG2205	protein histidine kinase activity
VSP_RS39585	COG5002	protein histidine kinase activity
VSP_RS39585	COG0784	Response regulator, receiver
VSP_RS39660	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
VSP_RS39690	COG2815	serine threonine protein kinase
VSP_RS39690	COG0515	serine threonine protein kinase
VSP_RS39700	COG0515	serine threonine protein kinase
VSP_RS39700	COG2815	serine threonine protein kinase
VSP_RS39705	COG4968	Prepilin-type N-terminal cleavage methylation domain
VSP_RS39710	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
VSP_RS39715	COG3275	phosphorelay sensor kinase activity
VSP_RS39755	COG0704	Plays a role in the regulation of phosphate uptake
VSP_RS39760	COG2715	membrane protein required for spore maturation
VSP_RS39775	COG0318	PFAM AMP-dependent synthetase and ligase
VSP_RS39850	COG2755	lipolytic protein G-D-S-L family
VSP_RS39870	COG1132	(ABC) transporter
VSP_RS39925	COG0358	DNA primase activity
VSP_RS39925	COG0305	Participates in initiation and elongation during chromosome replication
VSP_RS39935	COG0859	PFAM glycosyl transferase family 9
VSP_RS39990	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
VSP_RS40005	COG1252	NADH dehydrogenase
VSP_RS40015	COG0438	transferase activity, transferring glycosyl groups
VSP_RS40045	COG5002	protein histidine kinase activity
VSP_RS40080	COG0542	response to heat
VSP_RS40085	COG0542	response to heat
VSP_RS40110	COG4239	(ABC) transporter, permease
VSP_RS40145	COG1214	PFAM Peptidase M22, glycoprotease
VSP_RS40155	COG4968	Prepilin-type N-terminal cleavage methylation domain
VSP_RS40160	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
VSP_RS40170	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
VSP_RS40175	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
VSP_RS40230	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
VSP_RS40240	COG0745	RESPONSE REGULATOR receiver
VSP_RS40320	COG1215	transferase activity, transferring glycosyl groups
VSP_RS40330	COG0515	serine threonine protein kinase
VSP_RS40330	COG2815	serine threonine protein kinase
VSP_RS40335	COG0811	peptide transport
VSP_RS40340	COG0848	biopolymer transport protein
VSP_RS40350	COG1722	exodeoxyribonuclease VII activity
VSP_RS40380	COG0515	serine threonine protein kinase
VSP_RS40380	COG2815	serine threonine protein kinase
VSP_RS40385	COG1262	PFAM Formylglycine-generating sulfatase enzyme
VSP_RS40400	COG2815	serine threonine protein kinase
VSP_RS40400	COG0515	serine threonine protein kinase
VSP_RS40410	COG3118	belongs to the thioredoxin family
VSP_RS40425	COG2815	serine threonine protein kinase
VSP_RS40425	COG0515	serine threonine protein kinase
VSP_RS40445	COG2815	serine threonine protein kinase
VSP_RS40445	COG0515	serine threonine protein kinase
VSP_RS40455	COG1216	Glycosyl transferase, family 2
VSP_RS40455	COG0438	transferase activity, transferring glycosyl groups