locus-tag class description HUT12_RS00005 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HUT12_RS00025 ENOG4105CHR reductase HUT12_RS00035 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HUT12_RS00040 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HUT12_RS00085 ENOG41080XP Cbs domain HUT12_RS00090 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HUT12_RS00095 ENOG4105WH1 Two component transcriptional regulator luxr family HUT12_RS00100 ENOG4105BZU Histidine kinase HUT12_RS00150 ENOG4107SCK Monooxygenase HUT12_RS00155 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HUT12_RS00170 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HUT12_RS00175 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase HUT12_RS00180 ENOG4105CPC Aldo Keto reductase HUT12_RS00190 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HUT12_RS00215 ENOG4105CEY Amp-dependent synthetase and ligase HUT12_RS00220 ENOG4106PMH Extracellular solute-binding protein family 3 HUT12_RS00225 ENOG4105E5Q amino acid AbC transporter HUT12_RS00235 ENOG4107QX3 carboxylase HUT12_RS00240 ENOG4105C1G acyl-Coa dehydrogenase HUT12_RS00260 ENOG4108YYC ycei family HUT12_RS00315 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin HUT12_RS00320 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family HUT12_RS00335 ENOG4105TV9 FHA Domain-Containing protein HUT12_RS00335 ENOG4105TV9 FHA Domain-Containing protein HUT12_RS00340 ENOG4105HZM Fha domain containing protein HUT12_RS00355 ENOG4105CJN penicillin-binding protein HUT12_RS00360 ENOG4107TPY serine threonine protein kinase HUT12_RS00365 ENOG4105D9P serine threonine protein kinase HUT12_RS00400 ENOG4105ZJT Cell division protein CrgA HUT12_RS00405 ENOG4105DF6 Fe-S oxidoreductase HUT12_RS00410 ENOG4105K4H Nlp p60 protein HUT12_RS00420 ENOG4105DHP deoxycytidine triphosphate deaminase HUT12_RS00450 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HUT12_RS00490 ENOG4105DYW oxidoreductase HUT12_RS00505 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) HUT12_RS00510 ENOG4105K6T rare lipoprotein A HUT12_RS00520 ENOG4105CSU acyl-Coa dehydrogenase HUT12_RS00530 ENOG4105M4E phosphohistidine phosphatase, SixA HUT12_RS00555 ENOG4105E7W lamb ycsf family protein HUT12_RS00575 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 HUT12_RS00580 ENOG4105CPP Dehydrogenase, E1 component HUT12_RS00625 ENOG4105CFG Acts as a chaperone (By similarity) HUT12_RS00630 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ HUT12_RS00635 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HUT12_RS00640 ENOG4105KNI merR family transcriptional Regulator HUT12_RS00655 ENOG4107W2M Sodium hydrogen exchanger HUT12_RS00675 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HUT12_RS00705 ENOG4105CHR reductase HUT12_RS00715 ENOG4107YCR Transcriptional regulator, ARSR family HUT12_RS00725 ENOG4107S1Q Phosphatase HUT12_RS00740 ENOG41082T9 Membrane HUT12_RS00745 ENOG4107RCW fructose-bisphosphate aldolase HUT12_RS00770 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HUT12_RS00785 ENOG4105C12 Phosphoribosylglycinamide synthetase HUT12_RS00820 ENOG4105CEY Amp-dependent synthetase and ligase HUT12_RS00825 ENOG4105C1G acyl-Coa dehydrogenase HUT12_RS00835 ENOG4108W9H Tetr family transcriptional regulator HUT12_RS00845 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HUT12_RS00870 ENOG4105CHR reductase HUT12_RS00875 ENOG4105CHU acetyl-coa acetyltransferase HUT12_RS00880 ENOG4105C83 adenylosuccinate lyase HUT12_RS00885 ENOG41082VC UPF0145 protein HUT12_RS00895 ENOG410839H phosphoribosylformylglycinamidine synthase HUT12_RS00900 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I HUT12_RS00905 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii HUT12_RS00930 ENOG4105CXB phosphoribosylaminoimidazole synthetase HUT12_RS00980 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HUT12_RS00985 ENOG4105E39 Enoyl-CoA hydratase HUT12_RS01035 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) HUT12_RS01055 ENOG4105CVP deoxyribo-dipyrimidine photolyase HUT12_RS01065 ENOG4105ETE Transcriptional regulator (LacI family HUT12_RS01070 ENOG4108IJG ABC transporter substrate-binding protein HUT12_RS01080 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component HUT12_RS01085 ENOG4105CG3 alpha amylase, catalytic region HUT12_RS01185 ENOG4105BZU Histidine kinase HUT12_RS01200 ENOG4105WH1 Two component transcriptional regulator luxr family HUT12_RS01255 ENOG4107P5I polyketide synthase HUT12_RS01335 ENOG4105E2Y ABC, transporter HUT12_RS01350 ENOG4108ZXC Two component transcriptional regulator, luxr family HUT12_RS01360 ENOG4105DKK Benzoate HUT12_RS01375 ENOG41080FJ Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) HUT12_RS01380 ENOG4105JXH GntR family transcriptional regulator HUT12_RS01385 ENOG4105DJ2 Major Facilitator Superfamily HUT12_RS01395 ENOG4107MMM Anti-sigma-factor antagonist HUT12_RS01400 ENOG4105FUA antagonist HUT12_RS01405 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase HUT12_RS01415 ENOG4105BZU Histidine kinase HUT12_RS01420 ENOG4105E3W Two component transcriptional regulator (Winged helix family HUT12_RS01450 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HUT12_RS01465 ENOG4105CQB FAD linked oxidase domain protein HUT12_RS01490 ENOG4105C12 Phosphoribosylglycinamide synthetase HUT12_RS01525 ENOG4105CEY Amp-dependent synthetase and ligase HUT12_RS01530 ENOG4105C1G acyl-Coa dehydrogenase HUT12_RS01540 ENOG4108W9H Tetr family transcriptional regulator HUT12_RS01550 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HUT12_RS01575 ENOG4105CHR reductase HUT12_RS01580 ENOG4105CHU acetyl-coa acetyltransferase HUT12_RS01585 ENOG4105C83 adenylosuccinate lyase HUT12_RS01590 ENOG41082VC UPF0145 protein HUT12_RS01600 ENOG410839H phosphoribosylformylglycinamidine synthase HUT12_RS01605 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I HUT12_RS01610 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii HUT12_RS01635 ENOG4105CXB phosphoribosylaminoimidazole synthetase HUT12_RS01685 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HUT12_RS01690 ENOG4105E39 Enoyl-CoA hydratase HUT12_RS01740 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) HUT12_RS01760 ENOG4105CVP deoxyribo-dipyrimidine photolyase HUT12_RS01770 ENOG4105ETE Transcriptional regulator (LacI family HUT12_RS01775 ENOG4108IJG ABC transporter substrate-binding protein HUT12_RS01785 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component HUT12_RS01790 ENOG4105CG3 alpha amylase, catalytic region HUT12_RS01890 ENOG4105BZU Histidine kinase HUT12_RS01905 ENOG4105WH1 Two component transcriptional regulator luxr family HUT12_RS01960 ENOG4107P5I polyketide synthase HUT12_RS02040 ENOG4105E2Y ABC, transporter HUT12_RS02055 ENOG4108ZXC Two component transcriptional regulator, luxr family HUT12_RS02065 ENOG4105DKK Benzoate HUT12_RS02080 ENOG41080FJ Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) HUT12_RS02085 ENOG4105JXH GntR family transcriptional regulator HUT12_RS02090 ENOG4105DJ2 Major Facilitator Superfamily HUT12_RS02100 ENOG4107MMM Anti-sigma-factor antagonist HUT12_RS02105 ENOG4105FUA antagonist HUT12_RS02110 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase HUT12_RS02120 ENOG4105BZU Histidine kinase HUT12_RS02125 ENOG4105E3W Two component transcriptional regulator (Winged helix family HUT12_RS02155 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HUT12_RS02170 ENOG4105CQB FAD linked oxidase domain protein HUT12_RS02180 ENOG4105BZU Histidine kinase HUT12_RS02185 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HUT12_RS02190 ENOG4105WN5 stage II sporulation protein HUT12_RS02195 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HUT12_RS02200 ENOG4108RH7 phosphoglycerate mutase HUT12_RS02210 ENOG4107QIV Cytochrome c biogenesis protein HUT12_RS02220 ENOG4105CRE cytochrome C HUT12_RS02250 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HUT12_RS02265 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HUT12_RS02275 ENOG4108XM1 transcriptional regulator AsnC family HUT12_RS02290 ENOG4105C1J atp-dependent rna helicase HUT12_RS02305 ENOG4105K4H Nlp p60 protein HUT12_RS02310 ENOG4105DVY radical SAM domain protein HUT12_RS02330 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HUT12_RS02335 ENOG4108U1V ABC transporter, permease HUT12_RS02340 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HUT12_RS02355 ENOG4108M15 ABC transporter HUT12_RS02360 ENOG4105EEM helicase HUT12_RS02365 ENOG4105EV6 Pfam:DUF178 HUT12_RS02380 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit HUT12_RS02385 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit HUT12_RS02390 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit HUT12_RS02395 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit HUT12_RS02400 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HUT12_RS02410 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) HUT12_RS02420 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HUT12_RS02440 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT12_RS02445 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HUT12_RS02450 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT12_RS02465 ENOG4108IEH NADH dehydrogenase subunit g HUT12_RS02475 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT12_RS02480 ENOG4105DF2 NADH dehydrogenase subunit j HUT12_RS02485 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT12_RS02500 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT12_RS02590 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HUT12_RS02650 ENOG4105CNU cell division protein FtsK HUT12_RS02745 ENOG4108I5C dEAD DEAH box helicase HUT12_RS02750 ENOG4105WN5 stage II sporulation protein HUT12_RS02760 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for HUT12_RS02775 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HUT12_RS02785 ENOG4108SGK Tetr family transcriptional regulator HUT12_RS02795 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) HUT12_RS02800 ENOG4105C6E dna polymerase iii HUT12_RS02820 ENOG4105MA4 psp1 domain protein HUT12_RS02860 ENOG4105CAF HipA N-terminal domain protein HUT12_RS02900 ENOG4108Z0Z intracellular protease Pfpi family HUT12_RS02910 ENOG41062IR nudix hydrolase HUT12_RS02915 ENOG4105CPQ Dehydrogenase HUT12_RS02920 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 HUT12_RS02930 ENOG41081K0 peptidylprolyl cis-trans isomerase HUT12_RS02935 ENOG4105FDF Could be involved in DNA repair (By similarity) HUT12_RS02940 ENOG4105DQE DNA ligase HUT12_RS02945 ENOG4105DQE DNA ligase HUT12_RS02975 ENOG4105CFI type iii restriction protein res subunit HUT12_RS02995 ENOG4105VEQ Cold shock protein HUT12_RS03000 ENOG4105E63 Pfam:DUF178 HUT12_RS03010 ENOG4108UIH futalosine nucleosidase HUT12_RS03015 ENOG4108N0W Major Facilitator superfamily HUT12_RS03030 ENOG4105C7N Xanthine uracil vitamin C permease HUT12_RS03040 ENOG4107SFI Major Facilitator superfamily HUT12_RS03055 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) HUT12_RS03065 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) HUT12_RS03075 ENOG4107WI4 Aldose-1-epimerase HUT12_RS03090 ENOG4105C1G acyl-Coa dehydrogenase HUT12_RS03105 ENOG4105EJQ L-serine dehydratase HUT12_RS03115 ENOG4105EY8 ABC transporter HUT12_RS03125 ENOG4107SJB teichoic acid biosynthesis HUT12_RS03130 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HUT12_RS03230 ENOG4105VPX protein, conserved in bacteria HUT12_RS03250 ENOG41067RQ csbd family HUT12_RS03265 ENOG4105BZP glycoside hydrolase 15-related HUT12_RS03280 ENOG4105KK4 UPF0060 membrane protein HUT12_RS03290 ENOG4105BZ1 (ABC) transporter HUT12_RS03305 ENOG4105DBE peroxidase HUT12_RS03355 ENOG4105R8C Transcriptional regulator HUT12_RS03360 ENOG4105CPC Aldo Keto reductase HUT12_RS03370 ENOG4105WH1 Two component transcriptional regulator luxr family HUT12_RS03380 ENOG4105CJ1 ABC, transporter HUT12_RS03485 ENOG4105EC2 ftsk spoIIIe HUT12_RS03490 ENOG41087ID Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) HUT12_RS03520 ENOG41090GG peptidase S8 and S53, subtilisin, kexin, sedolisin HUT12_RS03525 ENOG4106F1P AAA ATPase, central domain protein HUT12_RS03545 ENOG4105ECR NmrA family HUT12_RS03555 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HUT12_RS03565 ENOG4107SVH Potassium channel protein HUT12_RS03570 ENOG4105K56 Transcriptional regulator HUT12_RS03575 ENOG4107VWK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HUT12_RS03580 ENOG4105DQU oxidoreductase, subunit beta HUT12_RS03585 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein HUT12_RS03590 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HUT12_RS03595 ENOG4105EEI dihydropteroate synthase HUT12_RS03620 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HUT12_RS03630 ENOG4108UKI Enoyl-CoA hydratase HUT12_RS03645 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HUT12_RS03650 ENOG4107ZBN O-methyltransferase HUT12_RS03660 ENOG410630M Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HUT12_RS03675 ENOG4105CJW magnesium transporter HUT12_RS03680 ENOG4105JAB phenazine biosynthesis protein, phzf family HUT12_RS03745 ENOG41080RH Thioredoxin HUT12_RS03775 ENOG4105NAF rna polymerase sigma factor HUT12_RS03785 ENOG4105DB7 PHP domain protein HUT12_RS03790 ENOG41081FY multiple antibiotic resistance (MarC)-related HUT12_RS03830 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase HUT12_RS03840 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HUT12_RS03845 ENOG4105CVM Molybdenum cofactor synthesis domain protein HUT12_RS03865 ENOG4108UXE Protein tyrosine phosphatase HUT12_RS03875 ENOG41082YX Transcriptional regulator, arsr family HUT12_RS03890 ENOG410829K Lysine exporter protein (Lyse ygga) HUT12_RS03910 ENOG4105F6U Short-chain dehydrogenase reductase Sdr HUT12_RS03915 ENOG4105E4C Lytic transglycosylase catalytic HUT12_RS03920 ENOG4108Z6Z Transcriptional regulator HUT12_RS03940 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) HUT12_RS03990 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HUT12_RS04005 ENOG4105F8V Hydrolase, tatD family HUT12_RS04010 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HUT12_RS04015 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) HUT12_RS04020 ENOG4105C5H ABC transporter HUT12_RS04035 ENOG41067SE Tetr family transcriptional regulator HUT12_RS04055 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HUT12_RS04060 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HUT12_RS04065 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) HUT12_RS04070 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) HUT12_RS04075 ENOG4108RM3 Phosphatase with a broad specificity. Its primary physiological function is to dephosphorylate 3'-phosphoadenosine 5'-phosphate (PAP) and 3'-phosphoadenosine 5'-phosphosulfate (PAPS). Thus, plays a role in mycobacterial sulfur metabolism, since it can serve as a key regulator of the sulfate assimilation pathway by controlling the pools of PAP and PAPS in the cell. To a lesser extent, is also able to hydrolyze inositol 1-phosphate (I- 1-P), fructose 1,6-bisphosphate (FBP) (to fructose 6-phosphate (F- 6-P)) and AMP in vitro, but this might has no significance in vivo HUT12_RS04090 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) HUT12_RS04095 ENOG4105CMR udp-glucose 4-epimerase HUT12_RS04105 ENOG4105C31 Tryptophanyl-tRNA synthetase HUT12_RS04125 ENOG4105CG3 alpha amylase, catalytic region HUT12_RS04145 ENOG4105EG2 ABC transporter, permease HUT12_RS04155 ENOG4105DIH basic membrane HUT12_RS04165 ENOG4105UIB (ABC) transporter HUT12_RS04195 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HUT12_RS04210 ENOG4105GWZ Roadblock lc7 family protein HUT12_RS04235 ENOG4108JJ8 (ABC) transporter HUT12_RS04240 ENOG4108JJ9 ABC, transporter HUT12_RS04255 ENOG4105C26 Dehydrogenase HUT12_RS04260 ENOG4105C26 Dehydrogenase HUT12_RS04265 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) HUT12_RS04270 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) HUT12_RS04290 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain HUT12_RS04305 ENOG4107RM1 amidohydrolase HUT12_RS04370 ENOG4108JIK carboxylase HUT12_RS04390 ENOG4107WR6 Maf-like protein HUT12_RS04395 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HUT12_RS04435 ENOG4105D8K carboxyl transferase HUT12_RS04460 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) HUT12_RS04500 ENOG4108IAB Phoh family HUT12_RS04540 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HUT12_RS04545 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) HUT12_RS04570 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) HUT12_RS04620 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) HUT12_RS04665 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HUT12_RS04705 ENOG4105CHU acetyl-coa acetyltransferase HUT12_RS04735 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HUT12_RS04740 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HUT12_RS04745 ENOG4105DER m42 family HUT12_RS04755 ENOG4105CAQ asparagine synthetase HUT12_RS04760 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HUT12_RS04765 ENOG4105K59 histidine triad (HIT) protein HUT12_RS04790 ENOG4105C7B Threonine dehydratase HUT12_RS04795 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HUT12_RS04805 ENOG4105T1M mycothiol conjugate amidase mca HUT12_RS04815 ENOG4105BZU Histidine kinase HUT12_RS04820 ENOG4105C7Z Conserved Protein HUT12_RS04840 ENOG4105C6Y Udp-glucose 6-dehydrogenase HUT12_RS04870 ENOG4105BZ1 (ABC) transporter HUT12_RS04890 ENOG4105C0Z ABC transporter HUT12_RS04895 ENOG4108IV0 ABC, transporter HUT12_RS05005 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HUT12_RS05035 ENOG4105PMW Domain of unknown function (DUF1990) HUT12_RS05060 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HUT12_RS05255 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT12_RS05260 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HUT12_RS05270 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HUT12_RS05305 ENOG4105C0R drug resistance transporter emrb qaca subfamily HUT12_RS05315 ENOG4105DEN Luciferase family HUT12_RS05320 ENOG4105F0K SARP family transcriptional regulator HUT12_RS05335 ENOG4106ARF phosphopantetheine-binding protein HUT12_RS05340 ENOG4105CZS beta-ketoacyl synthase HUT12_RS05350 ENOG4107SQU synthase HUT12_RS05355 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HUT12_RS05370 ENOG4105EAD ABC transporter HUT12_RS05375 ENOG4105DEN Luciferase family HUT12_RS05400 ENOG4105CHR reductase HUT12_RS05430 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HUT12_RS05450 ENOG4105DYW oxidoreductase HUT12_RS05455 ENOG4106YT9 Enoyl-CoA hydratase HUT12_RS05470 ENOG4108M8W Monooxygenase HUT12_RS05475 ENOG4108M8W Monooxygenase HUT12_RS05485 ENOG4105D2B acyl-CoA dehydrogenase HUT12_RS05490 ENOG4105CEY Amp-dependent synthetase and ligase HUT12_RS05515 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr HUT12_RS05520 ENOG4105CHU acetyl-coa acetyltransferase HUT12_RS05535 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT12_RS05545 ENOG4108JQ6 ABC transporter HUT12_RS05550 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HUT12_RS05555 ENOG4105E9F Enoyl-CoA hydratase HUT12_RS05595 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HUT12_RS05640 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) HUT12_RS05660 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HUT12_RS05680 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HUT12_RS05695 ENOG4105EW9 transcriptional regulator AsnC family HUT12_RS05705 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HUT12_RS05710 ENOG4105F38 ABC transporter, permease HUT12_RS05715 ENOG4105D38 putrescine abc transporter HUT12_RS05730 ENOG4105CYW agmatinase HUT12_RS05740 ENOG4105F44 Two component transcriptional regulator, winged helix family HUT12_RS05745 ENOG4106F60 Histidine kinase HUT12_RS05755 ENOG4105CPF Cell wall formation (By similarity) HUT12_RS05765 ENOG4106SPC secreted protein HUT12_RS05795 ENOG4107QKV phosphomannomutase HUT12_RS05800 ENOG4105W49 UPF0434 protein HUT12_RS05820 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) HUT12_RS05845 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HUT12_RS05865 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUT12_RS05885 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea HUT12_RS05890 ENOG41068WN HUT12_RS05900 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HUT12_RS05925 ENOG4105C26 Dehydrogenase HUT12_RS05935 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) HUT12_RS05940 ENOG4105CAK Cell division ATP-binding protein ftsE HUT12_RS05945 ENOG4107RYD Part of the ABC transporter FtsEX involved in cellular division (By similarity) HUT12_RS05950 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) HUT12_RS05965 ENOG4105FP9 thiamine pyrophosphate HUT12_RS05970 ENOG4108UJU UPF0301 protein HUT12_RS06090 ENOG4105E5M Multidrug resistance protein D HUT12_RS06110 ENOG4105CEY Amp-dependent synthetase and ligase HUT12_RS06120 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HUT12_RS06135 ENOG4106YT9 Enoyl-CoA hydratase HUT12_RS06140 ENOG4105DYW oxidoreductase HUT12_RS06145 ENOG4107YCY Transcriptional regulator HUT12_RS06160 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HUT12_RS06185 ENOG4105CHU acetyl-coa acetyltransferase HUT12_RS06195 ENOG4105C1G acyl-Coa dehydrogenase HUT12_RS06200 ENOG4105CI0 Citrate lyase HUT12_RS06215 ENOG4105C1G acyl-Coa dehydrogenase HUT12_RS06230 ENOG4108TCS Glutamyl endopeptidase HUT12_RS06245 ENOG4105CEY Amp-dependent synthetase and ligase HUT12_RS06265 ENOG4105CEY Amp-dependent synthetase and ligase HUT12_RS06275 ENOG4105QV4 Tryptophan halogenase HUT12_RS06305 ENOG4105WQT MbtH domain protein HUT12_RS06315 ENOG4105CHR reductase HUT12_RS06355 ENOG4107RUY (E1 component), alpha subunit HUT12_RS06360 ENOG4105CPP Dehydrogenase, E1 component HUT12_RS06390 ENOG4105EET magnesium chelatase HUT12_RS06415 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HUT12_RS06465 ENOG4105BZU Histidine kinase HUT12_RS06470 ENOG4107TXC Transcriptional regulator HUT12_RS06495 ENOG4105C2C drug resistance transporter, Bcr CflA HUT12_RS06515 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) HUT12_RS06550 ENOG4105ECY inositol monophosphatase HUT12_RS06595 ENOG4105C0R drug resistance transporter emrb qaca subfamily HUT12_RS06620 ENOG4105CV8 reductase HUT12_RS06645 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HUT12_RS06690 ENOG4105BZU Histidine kinase HUT12_RS06695 ENOG4105WH1 Two component transcriptional regulator luxr family HUT12_RS06720 ENOG4105IIU Aminopeptidase HUT12_RS06770 ENOG41065SU Two-component system sensor kinase HUT12_RS06775 ENOG4108KXV response regulator HUT12_RS06805 ENOG4105BZP glycoside hydrolase 15-related HUT12_RS06820 ENOG4105CV8 reductase HUT12_RS06830 ENOG4105CYP glycoside hydrolase, family HUT12_RS06835 ENOG41061H0 Monooxygenase HUT12_RS06840 ENOG4105BZ9 Cytochrome C oxidase, subunit I HUT12_RS06850 ENOG4108RWI nicotinamidase HUT12_RS06855 ENOG4107RKP Nicotinate phosphoribosyltransferase HUT12_RS06860 ENOG4105WH1 Two component transcriptional regulator luxr family HUT12_RS06870 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) HUT12_RS06895 ENOG4108RQ5 Beta-lactamase domain-containing protein HUT12_RS06905 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) HUT12_RS06910 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HUT12_RS06915 ENOG4105C84 Histidine ammonia-lyase HUT12_RS06920 ENOG4105CI2 imidazolone-5-propionate hydrolase HUT12_RS06930 ENOG4105CE7 Amidase, hydantoinase carbamoylase family HUT12_RS06935 ENOG4105CGP Urocanate hydratase HUT12_RS06950 ENOG4105EXC Acyl-transferase HUT12_RS06980 ENOG4105D3Q Sugar transferase HUT12_RS06985 ENOG4108KGH TRANSCRIPTIONal HUT12_RS07035 ENOG4108JJB ABC transporter HUT12_RS07045 ENOG4108R9S DSBA oxidoreductase HUT12_RS07090 ENOG4105C57 major facilitator superfamily HUT12_RS07095 ENOG4108RFG Tetr family transcriptional regulator HUT12_RS07100 ENOG4107UBC ErfK ybiS ycfS ynhG family protein HUT12_RS07105 ENOG4107UBC ErfK ybiS ycfS ynhG family protein HUT12_RS07115 ENOG4105EYF MMPL domain protein HUT12_RS07125 ENOG4105CPC Aldo Keto reductase HUT12_RS07135 ENOG4105D0M Protease HtpX homolog HUT12_RS07165 ENOG41065SU Two-component system sensor kinase HUT12_RS07240 ENOG4105CJ1 ABC, transporter HUT12_RS07245 ENOG4105DKW ABC transporter HUT12_RS07250 ENOG4108RVA ribokinase HUT12_RS07300 ENOG4105VG5 Membrane HUT12_RS07320 ENOG4105C10 Electron transfer flavoprotein HUT12_RS07330 ENOG4105K6V RNA polymerase HUT12_RS07350 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) HUT12_RS07370 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HUT12_RS07375 ENOG4105BZU Histidine kinase HUT12_RS07380 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HUT12_RS07385 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HUT12_RS07395 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HUT12_RS07400 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HUT12_RS07430 ENOG4105ETE Transcriptional regulator (LacI family HUT12_RS07520 ENOG4105C01 Dihydroxy-acid dehydratase HUT12_RS07525 ENOG4105BZU Histidine kinase HUT12_RS07535 ENOG4108ZP8 Acetolactate synthase small subunit HUT12_RS07540 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HUT12_RS07545 ENOG4108JQ1 Dehydrogenase HUT12_RS07560 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HUT12_RS07565 ENOG4105CM2 brancheD-chain amino acid aminotransferase HUT12_RS07580 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HUT12_RS07595 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HUT12_RS07605 ENOG4107QVM von Willebrand factor, type A HUT12_RS07610 ENOG4105C0H protease HUT12_RS07620 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) HUT12_RS07660 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HUT12_RS07665 ENOG4107XER 3-isopropylmalate dehydratase, small subunit HUT12_RS07670 ENOG4105K70 DNA-binding protein HUT12_RS07685 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HUT12_RS07705 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HUT12_RS07710 ENOG4105C28 cystathionine HUT12_RS07715 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HUT12_RS07720 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) HUT12_RS07780 ENOG4105VB9 50S ribosomal protein l28 HUT12_RS07785 ENOG4105DP4 dak2 domain fusion protein ylov HUT12_RS07800 ENOG4106H78 methyltransferase HUT12_RS07805 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) HUT12_RS07820 ENOG41084BZ 50S ribosomal protein L32 HUT12_RS07825 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) HUT12_RS07830 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) HUT12_RS07835 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HUT12_RS07845 ENOG4105K4I Scp-like extracellular HUT12_RS07890 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) HUT12_RS07925 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) HUT12_RS07935 ENOG4105K5M 30s ribosomal protein S16 HUT12_RS07940 ENOG41082KU UPF0109 protein HUT12_RS07945 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) HUT12_RS07950 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) HUT12_RS07955 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) HUT12_RS07970 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HUT12_RS07975 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HUT12_RS08000 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HUT12_RS08015 ENOG41080R2 UPF0102 protein HUT12_RS08025 ENOG4105CE9 30S ribosomal protein S2 HUT12_RS08030 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) HUT12_RS08035 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HUT12_RS08040 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) HUT12_RS08045 ENOG4105KNE Phosphatidate cytidylyltransferase HUT12_RS08050 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs HUT12_RS08065 ENOG4107B57 rieske 2fe-2S domain-containing protein HUT12_RS08090 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) HUT12_RS08100 ENOG4105DZP Membrane-associated zinc metalloprotease HUT12_RS08105 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) HUT12_RS08120 ENOG4105BZ1 (ABC) transporter HUT12_RS08125 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HUT12_RS08135 ENOG4105CHF Glutathione S-transferase HUT12_RS08140 ENOG4105CHU acetyl-coa acetyltransferase HUT12_RS08165 ENOG4105C26 Dehydrogenase HUT12_RS08210 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT12_RS08230 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) HUT12_RS08245 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) HUT12_RS08255 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) HUT12_RS08260 ENOG4105SFS phosphoesterase RecJ domain protein HUT12_RS08285 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) HUT12_RS08295 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) HUT12_RS08300 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) HUT12_RS08305 ENOG4105C1V Peptidase, M16 HUT12_RS08310 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) HUT12_RS08315 ENOG4105VRR gCN5-related N-acetyltransferase HUT12_RS08330 ENOG4105T0Z Conserved Protein HUT12_RS08340 ENOG4107SMJ Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) HUT12_RS08345 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HUT12_RS08350 ENOG4105CN5 Metallo-Beta-Lactamase HUT12_RS08355 ENOG4106T9R serine protease HUT12_RS08370 ENOG4107QZI cell division protein FtsK HUT12_RS08390 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) HUT12_RS08400 ENOG4105CEV competence damage-inducible protein HUT12_RS08405 ENOG4105WBV Transcriptional regulator HUT12_RS08420 ENOG4105ETE Transcriptional regulator (LacI family HUT12_RS08440 ENOG4105DC7 peptidase M24 HUT12_RS08445 ENOG4108R85 Short chain dehydrogenase HUT12_RS08450 ENOG4108I5D sulfate abc transporter HUT12_RS08455 ENOG4105F38 ABC transporter, permease HUT12_RS08465 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HUT12_RS08470 ENOG4107STQ Multicopper oxidase HUT12_RS08475 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) HUT12_RS08500 ENOG4107QRT dEAD DEAH box helicase HUT12_RS08510 ENOG4105D65 subunit l HUT12_RS08515 ENOG4105MKQ Monovalent cation H antiporter subunit C HUT12_RS08520 ENOG4108JPZ Monovalent cation H antiporter subunit D HUT12_RS08530 ENOG41080TA Multiple resistance and ph regulation protein f HUT12_RS08535 ENOG4105KJM monovalent cation h antiporter subunit g HUT12_RS08550 ENOG4105C37 (CBS) domain HUT12_RS08555 ENOG4108N23 SpoOM-related protein HUT12_RS08560 ENOG4108NIW Leucine export protein LeuE HUT12_RS08570 ENOG4105CSW GntR family transcriptional regulator HUT12_RS08575 ENOG4108UN4 phage SPO1 DNA polymerase-related protein HUT12_RS08580 ENOG4105DXI Major Facilitator superfamily HUT12_RS08590 ENOG4107KFM Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) HUT12_RS08595 ENOG4105KC9 Modulates RecA activity (By similarity) HUT12_RS08600 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) HUT12_RS08605 ENOG4105DRP amino acid AbC transporter HUT12_RS08610 ENOG4105EAD ABC transporter HUT12_RS08615 ENOG4107UBR Extracellular solute-binding protein family 3 HUT12_RS08620 ENOG4105CDA abc transporter atp-binding protein HUT12_RS08625 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) HUT12_RS08640 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HUT12_RS08645 ENOG4105DBA pectate lyase HUT12_RS08650 ENOG4105C99 atpase involved in dna repair HUT12_RS08660 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) HUT12_RS08665 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) HUT12_RS08675 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HUT12_RS08685 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HUT12_RS08690 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) HUT12_RS08695 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HUT12_RS08730 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUT12_RS08740 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) HUT12_RS08745 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HUT12_RS08750 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin HUT12_RS08755 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HUT12_RS08760 ENOG4107QVT Binding-protein-dependent transport systems, inner membrane component HUT12_RS08765 ENOG4107QKW extracellular solute-binding protein family 1 HUT12_RS08785 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) HUT12_RS08795 ENOG4105EN6 Membrane HUT12_RS08840 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HUT12_RS08865 ENOG4107VEG TrkA-N domain protein HUT12_RS08870 ENOG4105C0X amino acid HUT12_RS08875 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HUT12_RS08880 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HUT12_RS08900 ENOG4105DRR Transcriptional regulator, GntR family HUT12_RS08910 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) HUT12_RS08940 ENOG4105F44 Two component transcriptional regulator, winged helix family HUT12_RS08945 ENOG4106F60 Histidine kinase HUT12_RS08965 ENOG4105CHU acetyl-coa acetyltransferase HUT12_RS08970 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) HUT12_RS08980 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) HUT12_RS08985 ENOG4105C1Q protoporphyrinogen oxidase HUT12_RS08990 ENOG4107JTW chlorite dismutase HUT12_RS08995 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) HUT12_RS09020 ENOG4105E0X reductase HUT12_RS09025 ENOG4105DQE DNA ligase HUT12_RS09055 ENOG4105C39 capsular polysaccharide phosphotransferase HUT12_RS09095 ENOG4105EYH Exonuclease HUT12_RS09100 ENOG4107RH8 nuclease SbcCD subunit D HUT12_RS09135 ENOG4105DRS transport system, permease HUT12_RS09145 ENOG4105ETE Transcriptional regulator (LacI family HUT12_RS09155 ENOG4105C1G acyl-Coa dehydrogenase HUT12_RS09200 ENOG4105CYP glycoside hydrolase, family HUT12_RS09220 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) HUT12_RS09225 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HUT12_RS09230 ENOG4107WHG Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HUT12_RS09380 ENOG4108S01 response regulator HUT12_RS09425 ENOG4108ZJ4 polysaccharide deacetylase HUT12_RS09440 ENOG4105ETE Transcriptional regulator (LacI family HUT12_RS09445 ENOG4105ETE Transcriptional regulator (LacI family HUT12_RS09480 ENOG4108YV4 Universal stress protein HUT12_RS09500 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HUT12_RS09515 ENOG410841Q phosphoesterase PA-phosphatase related protein HUT12_RS09530 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HUT12_RS09540 ENOG4108N23 SpoOM-related protein HUT12_RS09555 ENOG4105EEM helicase HUT12_RS09570 ENOG4108UYE Lactoylglutathione lyase HUT12_RS09580 ENOG4105EYW Ion transport protein HUT12_RS09605 ENOG4105CHR reductase HUT12_RS09610 ENOG4105KF0 sporulation and cell division protein, SsgA HUT12_RS09665 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HUT12_RS09685 ENOG4105ETE Transcriptional regulator (LacI family HUT12_RS09725 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HUT12_RS09735 ENOG410901E Membrane HUT12_RS09775 ENOG4105E0A ABC, transporter HUT12_RS09785 ENOG4105S6R Iron-hydroxamate transporter permease subunit HUT12_RS09800 ENOG4105CPQ Dehydrogenase HUT12_RS09820 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HUT12_RS09825 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HUT12_RS09835 ENOG4107TY6 Acylneuraminate cytidylyltransferase HUT12_RS09850 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HUT12_RS09855 ENOG4105C5E polysaccharide biosynthesis protein HUT12_RS09875 ENOG4105CHR reductase HUT12_RS09885 ENOG4105D2T synthase HUT12_RS09890 ENOG4105K64 Glycosyl transferase, family 2 HUT12_RS09930 ENOG4105EY8 ABC transporter HUT12_RS09940 ENOG4108JGH Tetr family transcriptional regulator HUT12_RS09960 ENOG4105XJC Two component transcriptional regulator (Winged helix family HUT12_RS09965 ENOG4105BZU Histidine kinase HUT12_RS09970 ENOG4105H1G trap transporter solute receptor taxi family HUT12_RS09980 ENOG4107XFJ UPF0246 protein HUT12_RS10000 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HUT12_RS10005 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) HUT12_RS10020 ENOG4107QPH glycogen) synthase HUT12_RS10025 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) HUT12_RS10040 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HUT12_RS10045 ENOG4107STW synthase HUT12_RS10065 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HUT12_RS10075 ENOG4105C0K Gdp-mannose 4,6-dehydratase HUT12_RS10085 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HUT12_RS10110 ENOG4108IAJ Nad-dependent epimerase dehydratase HUT12_RS10140 ENOG4105C5E polysaccharide biosynthesis protein HUT12_RS10145 ENOG4105D3Q Sugar transferase HUT12_RS10165 ENOG4105BZM domain protein HUT12_RS10170 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein HUT12_RS10190 ENOG4105E33 succinate dehydrogenase HUT12_RS10205 ENOG4105DUM transcriptional regulator, lysR family HUT12_RS10210 ENOG4105CQ7 ATP-dependent helicase HUT12_RS10235 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) HUT12_RS10255 ENOG4105CGK Exodeoxyribonuclease III HUT12_RS10285 ENOG4105C26 Dehydrogenase HUT12_RS10290 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HUT12_RS10310 ENOG4105CQ7 ATP-dependent helicase HUT12_RS10330 ENOG4105CUB amino acid HUT12_RS10360 ENOG4105EUB pirin domain protein HUT12_RS10370 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) HUT12_RS10375 ENOG4107VFM Dehydrogenase HUT12_RS10420 ENOG4107U9T Pfam:Ribonuclease_BN HUT12_RS10440 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) HUT12_RS10450 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HUT12_RS10460 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HUT12_RS10465 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) HUT12_RS10470 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) HUT12_RS10480 ENOG4105D16 lipopolysaccharide heptosyltransferase i HUT12_RS10510 ENOG4105C9U ATP-dependent DNA helicase RecQ HUT12_RS10515 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HUT12_RS10520 ENOG4105D17 glycoside hydrolase, family 3 domain protein HUT12_RS10560 ENOG4105VEQ Cold shock protein HUT12_RS10570 ENOG4105CPC Aldo Keto reductase HUT12_RS10575 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HUT12_RS10595 ENOG4105C22 threonyL-tRNA synthetase HUT12_RS10620 ENOG4107YQ3 lipid a biosynthesis lauroyl acyltransferase HUT12_RS10625 ENOG4105E2K Glycosyl transferase (Group 1 HUT12_RS10635 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) HUT12_RS10640 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) HUT12_RS10660 ENOG4105CDY transcriptional regulatory protein HUT12_RS10705 ENOG4108IUX (ABC) transporter HUT12_RS10710 ENOG4105WH1 Two component transcriptional regulator luxr family HUT12_RS10715 ENOG4108ZGX Histidine kinase HUT12_RS10725 ENOG4105D0M Protease HtpX homolog HUT12_RS10730 ENOG4108V0P LemA family HUT12_RS10745 ENOG4105C0B DNA polymerase III (alpha subunit) HUT12_RS10765 ENOG4105C57 major facilitator superfamily HUT12_RS10770 ENOG4108JGH Tetr family transcriptional regulator HUT12_RS10775 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN HUT12_RS10785 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) HUT12_RS10790 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) HUT12_RS10795 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HUT12_RS10800 ENOG4105VIE preprotein translocase, subunit YajC HUT12_RS10815 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) HUT12_RS10820 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HUT12_RS10825 ENOG4108ZR3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) HUT12_RS10840 ENOG4105CUT histidyl-tRNA synthetase HUT12_RS10860 ENOG4106NMR serine protease HUT12_RS10865 ENOG4105C9M aspartyl-trna synthetase HUT12_RS10885 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HUT12_RS10920 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HUT12_RS10925 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) HUT12_RS10935 ENOG4105E2X shikimate dehydrogenase HUT12_RS10955 ENOG4108UW5 maltose o-acetyltransferase HUT12_RS11000 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HUT12_RS11005 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HUT12_RS11010 ENOG4105D49 3-dehydroquinate synthase HUT12_RS11015 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) HUT12_RS11020 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HUT12_RS11025 ENOG410803B Involved in the transcription termination process (By similarity) HUT12_RS11035 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) HUT12_RS11040 ENOG4105CXT aspartate transcarbamylase HUT12_RS11045 ENOG4105CD3 dihydroorotase HUT12_RS11050 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HUT12_RS11060 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) HUT12_RS11065 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HUT12_RS11070 ENOG4105SKN orotidine 5''-phosphate decarboxylase HUT12_RS11080 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HUT12_RS11085 ENOG4105MTQ Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) HUT12_RS11095 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HUT12_RS11100 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HUT12_RS11110 ENOG4108Z4J Cytidine monophosphate kinase HUT12_RS11115 ENOG4106A3M Cytochrome p-450 HUT12_RS11120 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HUT12_RS11125 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) HUT12_RS11150 ENOG4105ETX regulatoR HUT12_RS11165 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HUT12_RS11170 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HUT12_RS11195 ENOG4105CDA abc transporter atp-binding protein HUT12_RS11200 ENOG4105EAD ABC transporter HUT12_RS11205 ENOG4105CT1 (ABC) transporter HUT12_RS11210 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase HUT12_RS11215 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) HUT12_RS11230 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HUT12_RS11235 ENOG41084BS 50S ribosomal protein L35 HUT12_RS11240 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) HUT12_RS11245 ENOG4108RWN rrna methyltransferase HUT12_RS11250 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) HUT12_RS11255 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HUT12_RS11260 ENOG4107V6Q Cyclic nucleotide-binding domain HUT12_RS11280 ENOG4108IJ1 Dehydrogenase HUT12_RS11290 ENOG4105CMR udp-glucose 4-epimerase HUT12_RS11295 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HUT12_RS11300 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) HUT12_RS11305 ENOG4105CAS nag kinase HUT12_RS11310 ENOG4105C8Y Acetylornithine aminotransferase HUT12_RS11315 ENOG4105DBV ornithine carbamoyltransferase HUT12_RS11325 ENOG4105CH7 arginosuccinase HUT12_RS11335 ENOG4108VX5 3-methyladenine DNA glycosylase HUT12_RS11345 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HUT12_RS11355 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HUT12_RS11365 ENOG4108YV4 Universal stress protein HUT12_RS11400 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) HUT12_RS11410 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HUT12_RS11435 ENOG4105DSU hydrolase HUT12_RS11460 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HUT12_RS11465 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HUT12_RS11490 ENOG4107QPH glycogen) synthase HUT12_RS11500 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HUT12_RS11505 ENOG4108YZ4 nudix hydrolase HUT12_RS11535 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) HUT12_RS11540 ENOG4105FE9 pseudouridine synthase HUT12_RS11545 ENOG4105CAT Cytidine monophosphate kinase HUT12_RS11550 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) HUT12_RS11570 ENOG4107QN1 sodium solute HUT12_RS11590 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HUT12_RS11605 ENOG4105SC1 monovalent cation H antiporter subunit E HUT12_RS11610 ENOG4108JPZ Monovalent cation H antiporter subunit D HUT12_RS11615 ENOG4105MKQ Monovalent cation H antiporter subunit C HUT12_RS11620 ENOG4105D65 subunit l HUT12_RS11630 ENOG4105CZN Potassium uptake protein HUT12_RS11635 ENOG4105DIM ABC transporter HUT12_RS11640 ENOG4105CIG ABC transporter HUT12_RS11645 ENOG4108X07 Tetr family transcriptional regulator HUT12_RS11655 ENOG4105EHG Permease protein HUT12_RS11665 ENOG4105NZG Ferredoxin HUT12_RS11685 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) HUT12_RS11690 ENOG4105CAQ asparagine synthetase HUT12_RS11695 ENOG4105C5F glutamine synthetase HUT12_RS11810 ENOG4105BZU Histidine kinase HUT12_RS11815 ENOG4105WH1 Two component transcriptional regulator luxr family HUT12_RS11895 ENOG4107SJ9 decarboxylase HUT12_RS11975 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) HUT12_RS11995 ENOG4105K6V RNA polymerase HUT12_RS12030 ENOG4105E2R ROK family HUT12_RS12045 ENOG4108WQI RNA Polymerase HUT12_RS12050 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HUT12_RS12055 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HUT12_RS12060 ENOG410680H amp-dependent synthetase and ligase HUT12_RS12065 ENOG4105E2T synthase III HUT12_RS12120 ENOG4105CNN ABC, transporter HUT12_RS12125 ENOG4105C2J ABC transporter HUT12_RS12150 ENOG4105IKQ hydratase HUT12_RS12155 ENOG4105DIV Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds (By similarity) HUT12_RS12160 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) HUT12_RS12210 ENOG4107RB3 L-asparaginase HUT12_RS12270 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT12_RS12275 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HUT12_RS12285 ENOG4105CEY Amp-dependent synthetase and ligase HUT12_RS12295 ENOG4105C84 Histidine ammonia-lyase HUT12_RS12320 ENOG4105ETX regulatoR HUT12_RS12325 ENOG4105BZU Histidine kinase HUT12_RS12340 ENOG4105KVH Transcriptional regulator HUT12_RS12370 ENOG4105D74 hydrolase HUT12_RS12415 ENOG4107S5I aldo keto reductase HUT12_RS12425 ENOG4105C26 Dehydrogenase HUT12_RS12440 ENOG4105DEF Extracellular solute-binding protein, family 5 HUT12_RS12455 ENOG4105KNY Microcompartments protein HUT12_RS12465 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) HUT12_RS12475 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml HUT12_RS12490 ENOG4107EFR Flavocytochrome c HUT12_RS12495 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HUT12_RS12500 ENOG4108UAU isochorismatase HUT12_RS12505 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HUT12_RS12510 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT12_RS12515 ENOG4105C3U ABC transporter HUT12_RS12525 ENOG4105DRR Transcriptional regulator, GntR family HUT12_RS12540 ENOG4105KVH Transcriptional regulator HUT12_RS12565 ENOG4108KX4 response regulator HUT12_RS12570 ENOG410829W Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) HUT12_RS12575 ENOG4105C1G acyl-Coa dehydrogenase HUT12_RS12605 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HUT12_RS12660 ENOG4105WN5 stage II sporulation protein HUT12_RS12725 ENOG4105C57 major facilitator superfamily HUT12_RS12750 ENOG4105C1G acyl-Coa dehydrogenase HUT12_RS12755 ENOG4107258 Transcriptional regulator HUT12_RS12760 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HUT12_RS12780 ENOG4105C32 Amino acid ABC transporter (Permease) HUT12_RS12790 ENOG4105C0Z ABC transporter HUT12_RS12795 ENOG4108IV0 ABC, transporter HUT12_RS12800 ENOG4107RUY (E1 component), alpha subunit HUT12_RS12805 ENOG4105CPP Dehydrogenase, E1 component HUT12_RS12815 ENOG4105C7K acetolactate synthase HUT12_RS12820 ENOG4108PZM peptidase S8 and S53, subtilisin, kexin, sedolisin HUT12_RS12845 ENOG4105EC2 ftsk spoIIIe HUT12_RS12905 ENOG4106F1P AAA ATPase, central domain protein HUT12_RS12935 ENOG4105GMT ATPase associated with various cellular activities aaa_5 HUT12_RS12950 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HUT12_RS12960 ENOG4108Z6Z Transcriptional regulator HUT12_RS12965 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin HUT12_RS13005 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) HUT12_RS13025 ENOG4105BZU Histidine kinase HUT12_RS13030 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUT12_RS13040 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT12_RS13045 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT12_RS13075 ENOG4107QUY Guanine deaminase HUT12_RS13105 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr HUT12_RS13120 ENOG4105EYF MMPL domain protein HUT12_RS13130 ENOG4107YBY Hydrolase HUT12_RS13225 ENOG4105DHI Methyltransferase HUT12_RS13260 ENOG4105CJ1 ABC, transporter HUT12_RS13300 ENOG4105BZ1 (ABC) transporter HUT12_RS13305 ENOG4105BZ1 (ABC) transporter HUT12_RS13320 ENOG4105DK7 lysyl-tRNA synthetase HUT12_RS13325 ENOG4105DG4 malate L-lactate dehydrogenase HUT12_RS13350 ENOG4106V2I dimethylaminohydrolase HUT12_RS13360 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HUT12_RS13385 ENOG4108JJB ABC transporter HUT12_RS13390 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) HUT12_RS13395 ENOG4108K4B hydrolase HUT12_RS13410 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) HUT12_RS13415 ENOG4106KS4 Sulfatase HUT12_RS13420 ENOG4108IAJ Nad-dependent epimerase dehydratase HUT12_RS13430 ENOG4105CEY Amp-dependent synthetase and ligase HUT12_RS13440 ENOG4105EWK phytoene HUT12_RS13475 ENOG4105C9B Cysteine desulfurase HUT12_RS13560 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) HUT12_RS13565 ENOG4105DIV Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds (By similarity) HUT12_RS13585 ENOG4105KNY Microcompartments protein HUT12_RS13605 ENOG4107TYC hydantoinase B oxoprolinase HUT12_RS13610 ENOG4107HP6 Transcriptional regulator HUT12_RS13615 ENOG4105C7K acetolactate synthase HUT12_RS13620 ENOG4105E39 Enoyl-CoA hydratase HUT12_RS13625 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase HUT12_RS13630 ENOG4105CEY Amp-dependent synthetase and ligase HUT12_RS13660 ENOG41083YR Protein CrcB homolog HUT12_RS13665 ENOG41083TI Protein CrcB homolog HUT12_RS13730 ENOG4105CT1 (ABC) transporter HUT12_RS13735 ENOG4105E5Q amino acid AbC transporter HUT12_RS13740 ENOG4105DRP amino acid AbC transporter HUT12_RS13775 ENOG4105BZU Histidine kinase HUT12_RS13780 ENOG4105WH1 Two component transcriptional regulator luxr family HUT12_RS13790 ENOG4105NPE arsR family transcriptional regulator HUT12_RS13805 ENOG4106NZI LysR family Transcriptional regulator HUT12_RS13835 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase HUT12_RS13870 ENOG4105KVH Transcriptional regulator HUT12_RS13910 ENOG4105C57 major facilitator superfamily HUT12_RS13915 ENOG4108RFG Tetr family transcriptional regulator HUT12_RS13970 ENOG41082BM Transcriptional regulator, arsr family HUT12_RS13985 ENOG4108CHM Preferentially cleaves peptide bonds on the carboxyl- terminal side of aspartate and glutamate. Along with other extracellular proteases it is involved in colonization and infection of human tissues. Required for proteolytic maturation of thiol protease SspB and inactivation of SspC, an inhibitor of SspB. It is the most important protease for degradation of fibronectin-binding protein (FnBP) and surface protein A, which are involved in adherence to host cells. May also protect bacteria against host defense mechanism by cleaving the immunoglobulin classes IgG, IgA and IgM. May be involved in the stability of secreted lipases HUT12_RS13990 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HUT12_RS13995 ENOG4107QR9 Iron-sulfur cluster binding protein HUT12_RS14000 ENOG41080R8 Conserved Protein HUT12_RS14020 ENOG4105CHU acetyl-coa acetyltransferase HUT12_RS14025 ENOG41090TK Short-chain dehydrogenase reductase Sdr HUT12_RS14035 ENOG410846T CoA-transferase family III HUT12_RS14050 ENOG4108KC2 acyl-Coa dehydrogenase HUT12_RS14055 ENOG4105EFA 4-hydroxyphenylacetate HUT12_RS14060 ENOG4105D2B acyl-CoA dehydrogenase HUT12_RS14075 ENOG4105CEY Amp-dependent synthetase and ligase HUT12_RS14080 ENOG4105E39 Enoyl-CoA hydratase HUT12_RS14085 ENOG4108SGK Tetr family transcriptional regulator HUT12_RS14090 ENOG4105DND Transcriptional regulator HUT12_RS14105 ENOG4108I05 Binding-protein-dependent transport systems, inner membrane component HUT12_RS14110 ENOG4105C1G acyl-Coa dehydrogenase HUT12_RS14120 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HUT12_RS14175 ENOG4105CEP NADH dehydrogenase HUT12_RS14185 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) HUT12_RS14195 ENOG4108T5E Copper resistance protein HUT12_RS14225 ENOG4105CMG Carbohydrate kinase HUT12_RS14235 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component HUT12_RS14245 ENOG4107VUR extracellular solute-binding protein HUT12_RS14260 ENOG4105DRR Transcriptional regulator, GntR family HUT12_RS14270 ENOG4105KKX ATPase associated with various cellular activities aaa_5 HUT12_RS14275 ENOG4105DEG Vwa containing coxe family protein HUT12_RS14350 ENOG4108M8W Monooxygenase HUT12_RS14365 ENOG4105KDC 50s ribosomal protein l28 HUT12_RS14370 ENOG4105W0E 50S ribosomal protein L33 HUT12_RS14375 ENOG41080FR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HUT12_RS14395 ENOG4107TYG Oxidoreductase domain-containing protein HUT12_RS14400 ENOG4105BZ7 extracellular solute-binding protein family 1 HUT12_RS14405 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HUT12_RS14415 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) HUT12_RS14420 ENOG4105CXK mandelate racemase muconate lactonizing HUT12_RS14425 ENOG4107R0V Pyruvate dehydrogenase HUT12_RS14455 ENOG4105NPE arsR family transcriptional regulator HUT12_RS14460 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase HUT12_RS14490 ENOG4105BZU Histidine kinase HUT12_RS14495 ENOG4105WH1 Two component transcriptional regulator luxr family HUT12_RS14510 ENOG4108JA1 polyketide synthase HUT12_RS14510 ENOG4108JA1 polyketide synthase HUT12_RS14520 ENOG4105MXW flavin reductase domain protein, FMN-binding HUT12_RS14525 ENOG4105C57 major facilitator superfamily HUT12_RS14540 ENOG4108RZE Tetr family transcriptional regulator HUT12_RS14555 ENOG4105CI2 imidazolone-5-propionate hydrolase HUT12_RS14585 ENOG4105WBV Transcriptional regulator HUT12_RS14595 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) HUT12_RS14600 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT12_RS14625 ENOG410880H cysteine synthase HUT12_RS14635 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HUT12_RS14685 ENOG4105CXK mandelate racemase muconate lactonizing HUT12_RS14695 ENOG4105C2J ABC transporter HUT12_RS14700 ENOG4105CNN ABC, transporter HUT12_RS14705 ENOG4105CNN ABC, transporter HUT12_RS14710 ENOG4105DFW ABC transporter HUT12_RS14715 ENOG4107TTA Xylose isomerase domain protein TIM barrel HUT12_RS14725 ENOG4108VEQ Superoxide dismutase HUT12_RS14750 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HUT12_RS14765 ENOG4107XKF NMT1 THI5 Like Domain Protein HUT12_RS14790 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HUT12_RS14800 ENOG4105DYW oxidoreductase HUT12_RS14825 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HUT12_RS14835 ENOG4105JXH GntR family transcriptional regulator HUT12_RS14860 ENOG4107TUS Dihydrodipicolinate synthase HUT12_RS14870 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HUT12_RS14895 ENOG4105CI2 imidazolone-5-propionate hydrolase HUT12_RS14930 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HUT12_RS14935 ENOG4105F38 ABC transporter, permease HUT12_RS14940 ENOG4105C26 Dehydrogenase HUT12_RS14950 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HUT12_RS14955 ENOG4105ETE Transcriptional regulator (LacI family HUT12_RS14960 ENOG4105C7K acetolactate synthase HUT12_RS14965 ENOG4105C26 Dehydrogenase HUT12_RS14970 ENOG4107THD Involved in phosphonate degradation (By similarity) HUT12_RS14980 ENOG41080QX K07048 phosphotriesterase-related protein HUT12_RS14985 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HUT12_RS15000 ENOG4105C26 Dehydrogenase HUT12_RS15005 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) HUT12_RS15010 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HUT12_RS15030 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HUT12_RS15040 ENOG4105CMG Carbohydrate kinase HUT12_RS15045 ENOG4105CPQ Dehydrogenase HUT12_RS15050 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) HUT12_RS15065 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase HUT12_RS15075 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HUT12_RS15085 ENOG4105CTK cobaltochelatase, cobn subunit HUT12_RS15090 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) HUT12_RS15130 ENOG4108M0I Transcriptional regulator HUT12_RS15135 ENOG4105CIR epoxide hydrolase HUT12_RS15150 ENOG4108ZGX Histidine kinase HUT12_RS15155 ENOG4105WH1 Two component transcriptional regulator luxr family HUT12_RS15160 ENOG4107SMB hydrolase Family 5 HUT12_RS15165 ENOG4105CFG Acts as a chaperone (By similarity) HUT12_RS15190 ENOG4105EYW Ion transport protein HUT12_RS15220 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HUT12_RS15225 ENOG4105DQ4 alcohol dehydrogenase HUT12_RS15240 ENOG4108W5M transcriptional regulator HUT12_RS15245 ENOG4105DHU Bile acid HUT12_RS15255 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 HUT12_RS15295 ENOG4105CTU Proline racemase HUT12_RS15300 ENOG4105C26 Dehydrogenase HUT12_RS15305 ENOG4108WYP Transcriptional regulator HUT12_RS15310 ENOG4105BZ1 (ABC) transporter HUT12_RS15315 ENOG4105BZ1 (ABC) transporter HUT12_RS15325 ENOG4106IQC argininosuccinate lyase HUT12_RS15340 ENOG4108I5D sulfate abc transporter HUT12_RS15345 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HUT12_RS15355 ENOG4105E2R ROK family HUT12_RS15360 ENOG4107RSM transcriptional regulator HUT12_RS15365 ENOG4108FN7 Aldo keto reductase HUT12_RS15395 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HUT12_RS15400 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT12_RS15410 ENOG4108JQ7 (ABC) transporter HUT12_RS15415 ENOG4107YXA Transcriptional regulator, BadM Rrf2 family HUT12_RS15420 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HUT12_RS15425 ENOG4108I5D sulfate abc transporter HUT12_RS15430 ENOG4105ECW sulfate abc transporter HUT12_RS15435 ENOG4108IJ6 ABC transporter HUT12_RS15445 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HUT12_RS15455 ENOG4105D7T ABC transporter HUT12_RS15475 ENOG4105D7K pfkb domain protein HUT12_RS15485 ENOG4105ETE Transcriptional regulator (LacI family HUT12_RS15495 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HUT12_RS15520 ENOG4105DFW ABC transporter HUT12_RS15530 ENOG4108HWW ABC transporter HUT12_RS15540 ENOG4105EX0 alpha-galactosidase HUT12_RS15545 ENOG4105EF1 ribulokinase HUT12_RS15555 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator HUT12_RS15560 ENOG4105C2J ABC transporter HUT12_RS15565 ENOG4107R9N ABC transporter HUT12_RS15570 ENOG41062B0 ABC transporter, permease HUT12_RS15575 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) HUT12_RS15595 ENOG4105ETE Transcriptional regulator (LacI family HUT12_RS15605 ENOG4107S46 esterase, PHB depolymerase HUT12_RS15615 ENOG4105C2J ABC transporter HUT12_RS15620 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane HUT12_RS15625 ENOG4105DIA mandelate racemase muconate lactonizing HUT12_RS15640 ENOG4105CPQ Dehydrogenase HUT12_RS15645 ENOG4105CHR reductase HUT12_RS15710 ENOG4108TMH cytolethal distending toxin HUT12_RS15725 ENOG4108M15 ABC transporter HUT12_RS15735 ENOG4107Z3H Transcriptional regulator, TetR family HUT12_RS15760 ENOG4105EMU Dehydrogenase HUT12_RS15840 ENOG4105VMP Transcriptional regulator HUT12_RS15850 ENOG4105ETE Transcriptional regulator (LacI family HUT12_RS15855 ENOG4105ETE Transcriptional regulator (LacI family HUT12_RS15870 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component HUT12_RS15900 ENOG4107S46 esterase, PHB depolymerase HUT12_RS15925 ENOG4106F60 Histidine kinase HUT12_RS15930 ENOG4105F44 Two component transcriptional regulator, winged helix family HUT12_RS15935 ENOG4105C0H protease HUT12_RS15940 ENOG4107QVM von Willebrand factor, type A HUT12_RS15950 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HUT12_RS15960 ENOG4107QP8 phosphohexose isomerase HUT12_RS15965 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HUT12_RS15970 ENOG4108N23 SpoOM-related protein HUT12_RS16060 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HUT12_RS16065 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HUT12_RS16095 ENOG4105WH1 Two component transcriptional regulator luxr family HUT12_RS16100 ENOG4105BZU Histidine kinase HUT12_RS16115 ENOG4106T9R serine protease HUT12_RS16135 ENOG41082SX arsR family transcriptional regulator HUT12_RS16155 ENOG4105CEY Amp-dependent synthetase and ligase HUT12_RS16180 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) HUT12_RS16200 ENOG4105DSG hydrolase family 43 HUT12_RS16220 ENOG4107HP6 Transcriptional regulator HUT12_RS16225 ENOG4108UHU Aldolase HUT12_RS16230 ENOG4105D7K pfkb domain protein HUT12_RS16235 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HUT12_RS16265 ENOG4107R9S Malate synthase HUT12_RS16285 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HUT12_RS16290 ENOG4105EHG Permease protein HUT12_RS16295 ENOG4107R4I Periplasmic binding protein HUT12_RS16375 ENOG4105C2C drug resistance transporter, Bcr CflA HUT12_RS16405 ENOG4105E98 transcriptional regulator DeoR family HUT12_RS16425 ENOG4105CPQ Dehydrogenase HUT12_RS16450 ENOG4108YYH Nadph-dependent fmn reductase HUT12_RS16485 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family HUT12_RS16515 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HUT12_RS16530 ENOG4105CF7 AraC family transcriptional regulator HUT12_RS16545 ENOG4105ERH Fumarylacetoacetate hydrolase HUT12_RS16570 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HUT12_RS16585 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HUT12_RS16605 ENOG4105WH1 Two component transcriptional regulator luxr family HUT12_RS16640 ENOG4105C3J Cysteine desulfurase HUT12_RS16645 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) HUT12_RS16650 ENOG4108YYC ycei family HUT12_RS16735 ENOG4105BZU Histidine kinase HUT12_RS16750 ENOG4107AQZ Membrane HUT12_RS16755 ENOG4105C0X amino acid HUT12_RS16760 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HUT12_RS16785 ENOG4105C75 arginyL-tRNA synthetase HUT12_RS16800 ENOG4107S91 Sodium hydrogen exchanger HUT12_RS16815 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HUT12_RS16835 ENOG4108RNG Permease of the drug metabolite transporter HUT12_RS16910 ENOG4105WH1 Two component transcriptional regulator luxr family HUT12_RS16915 ENOG4105BZU Histidine kinase HUT12_RS16935 ENOG4107VXZ Hydrolase HUT12_RS16940 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT12_RS16945 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT12_RS16950 ENOG4105WH1 Two component transcriptional regulator luxr family HUT12_RS16955 ENOG4105BZU Histidine kinase HUT12_RS16985 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) HUT12_RS16995 ENOG4105E5F proteasome HUT12_RS17000 ENOG4105WFD Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity) HUT12_RS17010 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) HUT12_RS17015 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) HUT12_RS17040 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase HUT12_RS17060 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) HUT12_RS17080 ENOG4107TMB Transcriptional regulator HUT12_RS17090 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HUT12_RS17115 ENOG4105DSG hydrolase family 43 HUT12_RS17135 ENOG4105CSU acyl-Coa dehydrogenase HUT12_RS17140 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) HUT12_RS17150 ENOG4105C0Z ABC transporter HUT12_RS17155 ENOG4108IV0 ABC, transporter HUT12_RS17160 ENOG4105C32 Amino acid ABC transporter (Permease) HUT12_RS17165 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HUT12_RS17195 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HUT12_RS17265 ENOG4107YCY Transcriptional regulator HUT12_RS17290 ENOG4105C1G acyl-Coa dehydrogenase HUT12_RS17300 ENOG4108Z7F N-acetyltransferase HUT12_RS17305 ENOG4105EGE secreted protein HUT12_RS17315 ENOG4105D29 Helix-turn-helix type 11 domain protein HUT12_RS17320 ENOG4105CIR epoxide hydrolase HUT12_RS17345 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha HUT12_RS17350 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase HUT12_RS17355 ENOG4105F2Z 3-oxoadipate enol-lactonase HUT12_RS17360 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase HUT12_RS17365 ENOG4107HP6 Transcriptional regulator HUT12_RS17425 ENOG4107QJG Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) HUT12_RS17430 ENOG4105C8U phosphate abc transporter HUT12_RS17435 ENOG4105E2Z phosphate ABC transporter (Permease HUT12_RS17440 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HUT12_RS17445 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HUT12_RS17470 ENOG4108KHX Diguanylate cyclase HUT12_RS17495 ENOG4107QPV Serine Threonine protein kinase HUT12_RS17515 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HUT12_RS17535 ENOG4105DZ1 carboxypeptidase HUT12_RS17540 ENOG4105DZ1 carboxypeptidase HUT12_RS17545 ENOG4108UQS dipeptidase HUT12_RS17565 ENOG4105D65 subunit l HUT12_RS17570 ENOG4105MKQ Monovalent cation H antiporter subunit C HUT12_RS17575 ENOG4108JPZ Monovalent cation H antiporter subunit D HUT12_RS17585 ENOG41080TA Multiple resistance and ph regulation protein f HUT12_RS17595 ENOG4105E0Y RtcB Protein HUT12_RS17625 ENOG4107QRS glycosyltransferase group 2 family protein HUT12_RS17630 ENOG4105C8Y Acetylornithine aminotransferase HUT12_RS17635 ENOG4105C1B dTDP-glucose 4-6-dehydratase HUT12_RS17640 ENOG4106YN8 Prenyltransferase HUT12_RS17650 ENOG4105K64 Glycosyl transferase, family 2 HUT12_RS17680 ENOG4108M15 ABC transporter HUT12_RS17685 ENOG4105BZU Histidine kinase HUT12_RS17690 ENOG4105WH1 Two component transcriptional regulator luxr family HUT12_RS17725 ENOG4105CPK Glycosyl transferase (Group 1 HUT12_RS17740 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) HUT12_RS17745 ENOG4105WCJ ec 1.1.1.193 HUT12_RS17770 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) HUT12_RS17780 ENOG4105DUU IucA IucC family protein HUT12_RS17805 ENOG41060NJ transcriptional regulator HUT12_RS17830 ENOG4105HFS 5'-3' exonuclease HUT12_RS17840 ENOG4105C1G acyl-Coa dehydrogenase HUT12_RS17845 ENOG4105J0Q Transcriptional regulator HUT12_RS17850 ENOG4105CVJ phosphoglycerate mutase HUT12_RS17865 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HUT12_RS17870 ENOG4105FRY Dehydrogenase HUT12_RS17875 ENOG4105CI2 imidazolone-5-propionate hydrolase HUT12_RS17880 ENOG4105EQ5 D-Lysine 5,6-aminomutase alpha subunit HUT12_RS17885 ENOG4107CHF 5,6-aminomutase beta subunit HUT12_RS17890 ENOG4108UYI beta-alanyl-CoA ammonia lyase HUT12_RS17915 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) HUT12_RS17925 ENOG4105Q70 HUT12_RS17940 ENOG4105ETE Transcriptional regulator (LacI family HUT12_RS17950 ENOG4105E2R ROK family HUT12_RS17965 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HUT12_RS17970 ENOG4105CJQ hydrolase, family 31 HUT12_RS17980 ENOG4105C0R drug resistance transporter emrb qaca subfamily HUT12_RS17985 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HUT12_RS18010 ENOG41087EV Hsp20/alpha crystallin family HUT12_RS18015 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HUT12_RS18025 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HUT12_RS18030 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT12_RS18045 ENOG4107W53 thymidine kinase HUT12_RS18050 ENOG4105DEU major facilitator superfamily HUT12_RS18075 ENOG4105PSQ Acyl-transferase HUT12_RS18080 ENOG4105C4M (Ubiquinol oxidase) subunit I HUT12_RS18085 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HUT12_RS18105 ENOG4105CHR reductase HUT12_RS18115 ENOG4105QPS Monooxygenase HUT12_RS18125 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) HUT12_RS18135 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HUT12_RS18150 ENOG4105C26 Dehydrogenase HUT12_RS18160 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HUT12_RS18175 ENOG4105CD3 dihydroorotase HUT12_RS18235 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HUT12_RS18250 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HUT12_RS18265 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HUT12_RS18365 ENOG4105EM7 Selenocysteine-specific translation elongation factor HUT12_RS18385 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HUT12_RS18410 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HUT12_RS18415 ENOG4107QZT geranylgeranyl reductase HUT12_RS18445 ENOG4105C5X domain protein HUT12_RS18480 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HUT12_RS18485 ENOG4105EPJ extracellular solute-binding protein family 1 HUT12_RS18490 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component HUT12_RS18495 ENOG4105F0K SARP family transcriptional regulator HUT12_RS18515 ENOG4105DDN Pentapeptide repeat-containing protein HUT12_RS18520 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HUT12_RS18560 ENOG4105K5B UPF0225 protein HUT12_RS18590 ENOG4105CBC glutamate synthase HUT12_RS18600 ENOG4105CSW GntR family transcriptional regulator HUT12_RS18615 ENOG4105WH1 Two component transcriptional regulator luxr family HUT12_RS18635 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HUT12_RS18640 ENOG4105CXK mandelate racemase muconate lactonizing HUT12_RS18650 ENOG4108RTU Aldolase HUT12_RS18655 ENOG4105CXK mandelate racemase muconate lactonizing HUT12_RS18660 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component HUT12_RS18695 ENOG4108KPJ rna polymerase sigma factor HUT12_RS18700 ENOG4105ECP epimerase HUT12_RS18745 ENOG4105WH1 Two component transcriptional regulator luxr family HUT12_RS18795 ENOG4105T38 integral membrane protein HUT12_RS18800 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HUT12_RS18805 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) HUT12_RS18845 ENOG4105CHR reductase HUT12_RS18850 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HUT12_RS18855 ENOG4105DTA methyltransferase HUT12_RS18860 ENOG4105CMR udp-glucose 4-epimerase HUT12_RS18905 ENOG4105DXX methyltransferase HUT12_RS18920 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) HUT12_RS18960 ENOG4108Z6Z Transcriptional regulator HUT12_RS18965 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HUT12_RS18980 ENOG41065SU Two-component system sensor kinase HUT12_RS18985 ENOG4108KXV response regulator HUT12_RS19000 ENOG4105WN5 stage II sporulation protein HUT12_RS19045 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HUT12_RS19065 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) HUT12_RS19075 ENOG4105CHR reductase HUT12_RS19080 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HUT12_RS19085 ENOG4105F2C Acetyl-CoA acetyltransferase HUT12_RS19095 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HUT12_RS19100 ENOG4105CJP fad dependent oxidoreductase HUT12_RS19110 ENOG4105C0W non-ribosomal peptide synthetase HUT12_RS19120 ENOG4107QVI Methyltransferase, type 11 HUT12_RS19130 ENOG4105CJP fad dependent oxidoreductase HUT12_RS19145 ENOG4105CC9 acyl-Coa dehydrogenase HUT12_RS19150 ENOG4108KC2 acyl-Coa dehydrogenase HUT12_RS19180 ENOG4105C0W non-ribosomal peptide synthetase HUT12_RS19185 ENOG4105C0W non-ribosomal peptide synthetase HUT12_RS19210 ENOG4106A3M Cytochrome p-450 HUT12_RS19225 ENOG4106A3M Cytochrome p-450 HUT12_RS19270 ENOG4105CHR reductase HUT12_RS19280 ENOG4105C26 Dehydrogenase HUT12_RS19310 ENOG4105E2Y ABC, transporter HUT12_RS19315 ENOG4105C0Z ABC transporter HUT12_RS19330 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein HUT12_RS19335 ENOG41083Z3 extracellular ligand-binding receptor HUT12_RS19355 ENOG4107S16 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) HUT12_RS19370 ENOG4105KI2 Urea amidohydrolase subunit beta HUT12_RS19380 ENOG4107R0W ABC transporter HUT12_RS19385 ENOG4105DRP amino acid AbC transporter HUT12_RS19390 ENOG4105CDA abc transporter atp-binding protein HUT12_RS19425 ENOG4105DIM ABC transporter HUT12_RS19430 ENOG4105CIG ABC transporter HUT12_RS19445 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HUT12_RS19450 ENOG4107FW0 short-chain dehydrogenase reductase HUT12_RS19455 ENOG4107TTQ Alpha beta hydrolase fold HUT12_RS19490 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HUT12_RS19495 ENOG4105GVF (ABC) transporter HUT12_RS19500 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HUT12_RS19505 ENOG4105E2Y ABC, transporter HUT12_RS19510 ENOG4105D63 family UPF0324 HUT12_RS19525 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) HUT12_RS19540 ENOG4105BZU Histidine kinase HUT12_RS19550 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 HUT12_RS19565 ENOG4105I82 acetyl xylan esterase HUT12_RS19585 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HUT12_RS19590 ENOG4105XN3 extracellular solute-binding protein family 1 HUT12_RS19615 ENOG4108JJB ABC transporter HUT12_RS19630 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) HUT12_RS19690 ENOG4107SJ9 decarboxylase HUT12_RS19705 ENOG4105PDP Short chain dehydrogenase HUT12_RS19735 ENOG4105EGE secreted protein HUT12_RS19740 ENOG4107RSM transcriptional regulator HUT12_RS19745 ENOG4105CHR reductase HUT12_RS19750 ENOG4108R86 Transcriptional regulator HUT12_RS19760 ENOG4105C3R Methionine synthase HUT12_RS19775 ENOG4105C8N cysteinyl-tRNA synthetase HUT12_RS19805 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HUT12_RS19810 ENOG4105DYW oxidoreductase HUT12_RS19815 ENOG4105CPC Aldo Keto reductase HUT12_RS19830 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HUT12_RS19860 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HUT12_RS19880 ENOG4105EC2 ftsk spoIIIe HUT12_RS19900 ENOG4107W19 lmbE family HUT12_RS19920 ENOG4107NHD transcriptional regulator HUT12_RS19925 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUT12_RS19940 ENOG4105JXB ankyrin repeat-containing protein HUT12_RS19960 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HUT12_RS19965 ENOG4105C3Q Glycosyl transferase, family 2 HUT12_RS19975 ENOG4105BZ9 Cytochrome C oxidase, subunit I HUT12_RS19980 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUT12_RS20005 ENOG4105EYF MMPL domain protein HUT12_RS20030 ENOG4105CDH Citrulline--aspartate ligase HUT12_RS20035 ENOG4108M0I Transcriptional regulator HUT12_RS20125 ENOG4105BZU Histidine kinase HUT12_RS20130 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUT12_RS20160 ENOG4105WN5 stage II sporulation protein HUT12_RS20175 ENOG4105WN5 stage II sporulation protein HUT12_RS20195 ENOG4107SJS nitrite reductase, (NAD(P)H) HUT12_RS20205 ENOG4107TVJ ,Oxidoreductase FAD NAD(P)-binding HUT12_RS20225 ENOG4105CJW magnesium transporter HUT12_RS20235 ENOG410846T CoA-transferase family III HUT12_RS20250 ENOG4105EUB pirin domain protein HUT12_RS20265 ENOG4107R37 Glutamate dehydrogenase HUT12_RS20275 ENOG4108Z4X TRANSCRIPTIONal HUT12_RS20310 ENOG4108QV3 biosynthesis protein HUT12_RS20330 ENOG41067HS methyltransferase HUT12_RS20335 ENOG4108V75 Glutamine amidotransferase HUT12_RS20340 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process HUT12_RS20360 ENOG4107TPY serine threonine protein kinase HUT12_RS20365 ENOG4107QQG Dehydrogenase HUT12_RS20380 ENOG4105WH1 Two component transcriptional regulator luxr family HUT12_RS20410 ENOG4105CAQ asparagine synthetase HUT12_RS20440 ENOG4105BZU Histidine kinase HUT12_RS20455 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HUT12_RS20475 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HUT12_RS20495 ENOG4107UBC ErfK ybiS ycfS ynhG family protein HUT12_RS20500 ENOG4107QSN dihydrolipoamide acetyltransferase HUT12_RS20515 ENOG4105EW9 transcriptional regulator AsnC family HUT12_RS20520 ENOG4105DQE DNA ligase HUT12_RS20525 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HUT12_RS20575 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) HUT12_RS20590 ENOG4108PDG Beta-ketoacyl synthase HUT12_RS20610 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HUT12_RS20615 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein HUT12_RS20620 ENOG4105D8K carboxyl transferase HUT12_RS20625 ENOG4105KTE polyketide synthesis cyclase HUT12_RS20640 ENOG41061H0 Monooxygenase HUT12_RS20675 ENOG4105WH1 Two component transcriptional regulator luxr family HUT12_RS20695 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HUT12_RS20705 ENOG4106UW1 Major Facilitator superfamily HUT12_RS20710 ENOG4105ETE Transcriptional regulator (LacI family HUT12_RS20800 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HUT12_RS20825 ENOG4105ETE Transcriptional regulator (LacI family HUT12_RS20865 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component HUT12_RS20870 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component HUT12_RS20885 ENOG4105DDC Oxidoreductase domain protein HUT12_RS20895 ENOG4105DIA mandelate racemase muconate lactonizing HUT12_RS20900 ENOG4105DEI Mannitol dehydrogenase HUT12_RS20905 ENOG4105CK5 oxidoreductase HUT12_RS20910 ENOG4108J20 pectate lyase HUT12_RS20930 ENOG4105BZU Histidine kinase HUT12_RS20955 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HUT12_RS20960 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HUT12_RS20975 ENOG4105E3B Multicopper oxidase HUT12_RS21000 ENOG4106R7G Glycoside hydrolase family 5 HUT12_RS21010 ENOG4105CPC Aldo Keto reductase HUT12_RS21015 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin HUT12_RS21035 ENOG4105BZU Histidine kinase HUT12_RS21090 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) HUT12_RS21115 ENOG4108V0P LemA family HUT12_RS21140 ENOG4105C57 major facilitator superfamily HUT12_RS21150 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HUT12_RS21170 ENOG4107RTD sua5 ycio yrdc ywlc family protein HUT12_RS21200 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) HUT12_RS21205 ENOG4105EHG Permease protein HUT12_RS21215 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HUT12_RS21220 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HUT12_RS21225 ENOG4105ETE Transcriptional regulator (LacI family HUT12_RS21240 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HUT12_RS21245 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component HUT12_RS21255 ENOG4108KGH TRANSCRIPTIONal HUT12_RS21270 ENOG4105CPK Glycosyl transferase (Group 1 HUT12_RS21335 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HUT12_RS21350 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr HUT12_RS21390 ENOG4105CYP glycoside hydrolase, family HUT12_RS21405 ENOG4105GWZ Roadblock lc7 family protein HUT12_RS21425 ENOG4105CS1 NAD(P)H quinone oxidoreductase HUT12_RS21440 ENOG4105ENE Histidine kinase HUT12_RS21450 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HUT12_RS21455 ENOG4107VXZ Hydrolase HUT12_RS21475 ENOG41082W1 Cupin 2, conserved barrel domain protein HUT12_RS21485 ENOG4105KBH arsR family transcriptional regulator HUT12_RS21495 ENOG4105JVQ RNA Polymerase HUT12_RS21500 ENOG4108MXQ glutathione-regulated potassium-efflux system ancillary protein KefF HUT12_RS21530 ENOG4105E1F short-chain dehydrogenase reductase HUT12_RS21560 ENOG4107USC Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) HUT12_RS21600 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUT12_RS21640 ENOG4105WH1 Two component transcriptional regulator luxr family HUT12_RS21725 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HUT12_RS21730 ENOG4108Z6Z Transcriptional regulator HUT12_RS21735 ENOG4105XEA Tetr family transcriptional regulator HUT12_RS21740 ENOG4105CHR reductase HUT12_RS21755 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) HUT12_RS21840 ENOG4105CJ1 ABC, transporter HUT12_RS21855 ENOG4105C0W non-ribosomal peptide synthetase HUT12_RS21865 ENOG4107SQU synthase HUT12_RS21880 ENOG4105C1G acyl-Coa dehydrogenase HUT12_RS21895 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HUT12_RS21960 ENOG4105D9P serine threonine protein kinase HUT12_RS21975 ENOG4107K5X Membrane-bound metal-dependent hydrolase HUT12_RS21980 ENOG4105ETE Transcriptional regulator (LacI family HUT12_RS21995 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component HUT12_RS22000 ENOG4105CJQ hydrolase, family 31 HUT12_RS22025 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit HUT12_RS22030 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding HUT12_RS22035 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HUT12_RS22040 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HUT12_RS22055 ENOG4105C2M dna polymerase I HUT12_RS22060 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase HUT12_RS22080 ENOG4108SU4 UPF0309 protein HUT12_RS22085 ENOG4106KNT transcriptional regulator HUT12_RS22095 ENOG4105RHY Pfam:UPF0157 HUT12_RS22105 ENOG4105C26 Dehydrogenase HUT12_RS22110 ENOG4105C8Y Acetylornithine aminotransferase HUT12_RS22125 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HUT12_RS22130 ENOG410783G HUT12_RS22150 ENOG4108UMS Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase (By similarity) HUT12_RS22155 ENOG4105DND Transcriptional regulator HUT12_RS22180 ENOG4105T0Z Conserved Protein HUT12_RS22195 ENOG4108JQ7 (ABC) transporter HUT12_RS22200 ENOG4105C3U ABC transporter HUT12_RS22205 ENOG4105DEF Extracellular solute-binding protein, family 5 HUT12_RS22220 ENOG4105C26 Dehydrogenase HUT12_RS22230 ENOG4105JSC dimethylmenaquinone methyltransferase HUT12_RS22250 ENOG4105J4Q Transcriptional regulator HUT12_RS22260 ENOG4108JQC penicillin-binding protein 1A HUT12_RS22290 ENOG4108UF8 HUT12_RS22300 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HUT12_RS22305 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HUT12_RS22330 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HUT12_RS22365 ENOG4105D7K pfkb domain protein HUT12_RS22380 ENOG4107T6F Xaa-Pro aminopeptidase HUT12_RS22440 ENOG4107QM5 aconitate hydratase HUT12_RS22455 ENOG4105GWZ Roadblock lc7 family protein HUT12_RS22495 ENOG4108Q5F Tetr family transcriptional regulator HUT12_RS22505 ENOG4105E18 UPF0276 protein HUT12_RS22520 ENOG4108VCA G U mismatch-specific DNA glycosylase HUT12_RS22525 ENOG4105BZ1 (ABC) transporter HUT12_RS22545 ENOG4105C5H ABC transporter HUT12_RS22550 ENOG4105CGZ zinc metallopeptidase HUT12_RS22560 ENOG4107Z1W Fructose transport system kinase HUT12_RS22575 ENOG4105CNN ABC, transporter HUT12_RS22580 ENOG4105C2J ABC transporter HUT12_RS22590 ENOG41080HJ 6-phospho 3-hexuloisomerase HUT12_RS22600 ENOG4105DEI Mannitol dehydrogenase HUT12_RS22605 ENOG4105KHC sulfurtransferase HUT12_RS22620 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin HUT12_RS22630 ENOG4108UNV SUF system FeS assembly protein, NifU family HUT12_RS22635 ENOG4105C9B Cysteine desulfurase HUT12_RS22640 ENOG4105C3K feS assembly ATPase SufC HUT12_RS22645 ENOG4105VQD rieske 2fe-2S domain-containing protein HUT12_RS22680 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) HUT12_RS22690 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HUT12_RS22695 ENOG4105C89 phosphohexose isomerase HUT12_RS22710 ENOG4107XU2 6-phosphogluconolactonase (EC 3.1.1.31) HUT12_RS22725 ENOG4105CP7 Triose-phosphate isomerase HUT12_RS22730 ENOG4105BZA Phosphoglycerate kinase HUT12_RS22735 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HUT12_RS22740 ENOG4105CIE May be required for sporulation (By similarity) HUT12_RS22750 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) HUT12_RS22760 ENOG4105C9U ATP-dependent DNA helicase RecQ HUT12_RS22765 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) HUT12_RS22785 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HUT12_RS22795 ENOG4105C5X domain protein HUT12_RS22825 ENOG4107RHI Cytosine-specific methyltransferase HUT12_RS22895 ENOG4108NF7 phage-type endonuclease HUT12_RS22980 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HUT12_RS23025 ENOG4105CDU Replicative dna helicase HUT12_RS23125 ENOG4108N0N Phage Terminase Large Subunit HUT12_RS23745 ENOG4105VEQ Cold shock protein HUT12_RS23765 ENOG4105EYF MMPL domain protein HUT12_RS23780 ENOG4105CI3 gtp-binding protein typa HUT12_RS23790 ENOG4105M2Z protein tyrosine serine phosphatase HUT12_RS23805 ENOG41061CK Antibiotic biosynthesis monooxygenase HUT12_RS23825 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HUT12_RS23830 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HUT12_RS23835 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HUT12_RS23850 ENOG4108Z6Z Transcriptional regulator HUT12_RS23860 ENOG4108IV0 ABC, transporter HUT12_RS23865 ENOG4105C0Z ABC transporter HUT12_RS23870 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HUT12_RS23875 ENOG4105C32 Amino acid ABC transporter (Permease) HUT12_RS23880 ENOG4105CP9 extracellular ligand-binding receptor HUT12_RS23915 ENOG4105DEN Luciferase family HUT12_RS23920 ENOG4105CX8 fg-gap repeat protein HUT12_RS23930 ENOG410635A Membrane HUT12_RS23940 ENOG4105C29 acyl-CoA thioesterase HUT12_RS23955 ENOG4107S5I aldo keto reductase HUT12_RS23965 ENOG4105EE5 Membrane protein terC HUT12_RS24030 ENOG4105CBC glutamate synthase HUT12_RS24045 ENOG4107TBN Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) HUT12_RS24050 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) HUT12_RS24055 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HUT12_RS24060 ENOG4105DK0 Indole-3-glycerol phosphate synthase HUT12_RS24080 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HUT12_RS24085 ENOG4105CIG ABC transporter HUT12_RS24105 ENOG4105BZ1 (ABC) transporter HUT12_RS24110 ENOG4105BZ1 (ABC) transporter HUT12_RS24120 ENOG4108X7A Terpene synthase metal-binding domain-containing protein HUT12_RS24125 ENOG4108IQE Amp-dependent synthetase and ligase HUT12_RS24135 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HUT12_RS24150 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) HUT12_RS24155 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HUT12_RS24165 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HUT12_RS24175 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HUT12_RS24180 ENOG4105CIH Imidazole acetol-phosphate transaminase HUT12_RS24185 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HUT12_RS24190 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HUT12_RS24215 ENOG4107ZIW This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) HUT12_RS24245 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) HUT12_RS24255 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HUT12_RS24265 ENOG4105DFU Cell wall formation (By similarity) HUT12_RS24270 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HUT12_RS24280 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) HUT12_RS24290 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HUT12_RS24295 ENOG4105CJN penicillin-binding protein HUT12_RS24305 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) HUT12_RS24310 ENOG4108V6E Cell division protein mraZ HUT12_RS24320 ENOG4105F1K Glutamine amidotransferase HUT12_RS24330 ENOG4105C8T Leucyl-tRNA synthetase HUT12_RS24335 ENOG4105KJM monovalent cation h antiporter subunit g HUT12_RS24350 ENOG4108JPZ Monovalent cation H antiporter subunit D HUT12_RS24355 ENOG4108ZE9 Monovalent cation H antiporter subunit C HUT12_RS24360 ENOG4105D65 subunit l HUT12_RS24365 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HUT12_RS24375 ENOG4105F8C transglutaminase domain-containing protein HUT12_RS24385 ENOG4107VJY DNA polymerase HUT12_RS24400 ENOG4105C0B DNA polymerase III (alpha subunit) HUT12_RS24420 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HUT12_RS24425 ENOG4108ZIP spheroidene monooxygenase HUT12_RS24475 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) HUT12_RS24485 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase HUT12_RS24510 ENOG4108IJ7 Glycine betaine HUT12_RS24515 ENOG4108HQS Glycine betaine HUT12_RS24535 ENOG4105D9U N-acetyltransferase HUT12_RS24555 ENOG4105CTQ phosphohexokinase HUT12_RS24580 ENOG4105F8J Adenylate Guanylate cyclase HUT12_RS24595 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase HUT12_RS24605 ENOG4105H3G oxidoreductase HUT12_RS24615 ENOG4105DKQ ROK family HUT12_RS24640 ENOG4105WH1 Two component transcriptional regulator luxr family HUT12_RS24650 ENOG4105BZU Histidine kinase HUT12_RS24655 ENOG4105JNK Glycosyl transferase (Group 1 HUT12_RS24660 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 HUT12_RS24675 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HUT12_RS24680 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HUT12_RS24685 ENOG4108S0S Nucleotidyl transferase HUT12_RS24700 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HUT12_RS24710 ENOG4107UDY cytochrome C HUT12_RS24730 ENOG4107S1N anthranilate phosphoribosyltransferase HUT12_RS24740 ENOG4108ZRS Part of cytochrome c oxidase, its function is HUT12_RS24745 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) HUT12_RS24750 ENOG4105C3J Cysteine desulfurase HUT12_RS24775 ENOG4107T4Z adenosine kinase HUT12_RS24790 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) HUT12_RS24795 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HUT12_RS24810 ENOG4108UMN azlc family HUT12_RS24815 ENOG4108IMY Transcriptional regulator HUT12_RS24825 ENOG4105CPC Aldo Keto reductase HUT12_RS24830 ENOG4107XZ0 Peptidase M50 HUT12_RS24845 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) HUT12_RS24850 ENOG410813T Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) HUT12_RS24860 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HUT12_RS24865 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HUT12_RS24920 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HUT12_RS24940 ENOG4105C5S asparaginyl-tRNA synthetase HUT12_RS24945 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HUT12_RS25015 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HUT12_RS25025 ENOG4105C5F glutamine synthetase HUT12_RS25030 ENOG41072RD Membrane HUT12_RS25035 ENOG4107JC6 Membrane HUT12_RS25045 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) HUT12_RS25050 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HUT12_RS25055 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HUT12_RS25065 ENOG4105P3N Membrane HUT12_RS25070 ENOG4105C5F glutamine synthetase HUT12_RS25075 ENOG4105C4K Nad synthetase HUT12_RS25080 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) HUT12_RS25095 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HUT12_RS25125 ENOG41086D8 Transcriptional regulator HUT12_RS25140 ENOG4105FDP GntR family transcriptional regulator HUT12_RS25195 ENOG4107QZI cell division protein FtsK HUT12_RS25235 ENOG41089N3 Inherit from COG: cobyrinic Acid a,c-diamide synthase HUT12_RS25265 ENOG4105EGD dinuclear metal center protein, YbgI family HUT12_RS25295 ENOG4108JA0 Oxidoreductase, FAD NAD(P)-binding domain protein HUT12_RS25315 ENOG4107XWB Zinc finger, swim domain protein HUT12_RS25320 ENOG4105C0D helicase HUT12_RS25350 ENOG4105NAE bifunctional deaminase-reductase domain protein HUT12_RS25355 ENOG4107YUH hydrolase HUT12_RS25375 ENOG4105CPP Dehydrogenase, E1 component HUT12_RS25385 ENOG4107ZED Uncharacterised protein family UPF0047 HUT12_RS25390 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HUT12_RS25415 ENOG4105C0R drug resistance transporter emrb qaca subfamily HUT12_RS25420 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HUT12_RS25445 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HUT12_RS25450 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HUT12_RS25475 ENOG4108V9Q carbonic anhydrase HUT12_RS25485 ENOG4105EEM helicase HUT12_RS25495 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) HUT12_RS25525 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HUT12_RS25530 ENOG41061ZR Transcriptional regulator HUT12_RS25545 ENOG4105EG6 Saccharopine dehydrogenase HUT12_RS25550 ENOG4108Z6Z Transcriptional regulator HUT12_RS25555 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) HUT12_RS25600 ENOG4105QE3 oxidoreductase HUT12_RS25615 ENOG4105BZ1 (ABC) transporter HUT12_RS25635 ENOG4105DVE abc transporter atp-binding protein HUT12_RS25670 ENOG4105CHP RNA polymerase HUT12_RS25785 ENOG4105DB3 bacteriochlorophyll chlorophyll a synthase HUT12_RS25810 ENOG4105CNN ABC, transporter HUT12_RS25815 ENOG4105C2J ABC transporter HUT12_RS25845 ENOG4105GWZ Roadblock lc7 family protein HUT12_RS25850 ENOG4105H1G trap transporter solute receptor taxi family HUT12_RS25880 ENOG4105C94 Transporter HUT12_RS25890 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein HUT12_RS25905 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HUT12_RS25910 ENOG4105E2D ec 3.2.1.52 HUT12_RS25930 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HUT12_RS25935 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HUT12_RS25940 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HUT12_RS25945 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation HUT12_RS25970 ENOG4108AQF aminoglycoside N(3)-acetyltransferase HUT12_RS26000 ENOG4108YZG isomerase HUT12_RS26010 ENOG4105MC2 DSBA oxidoreductase HUT12_RS26020 ENOG4109057 HUT12_RS26040 ENOG4105C3W Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate (By similarity) HUT12_RS26055 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) HUT12_RS26060 ENOG4105DIV Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds (By similarity) HUT12_RS26075 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) HUT12_RS26080 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) HUT12_RS26085 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) HUT12_RS26110 ENOG4105D8X mechanosensitive ion channel HUT12_RS26120 ENOG4108Z18 K06886 hemoglobin HUT12_RS26145 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase HUT12_RS26150 ENOG4105VNY Trehalose 6-phosphate phosphatase HUT12_RS26160 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HUT12_RS26165 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) HUT12_RS26180 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HUT12_RS26190 ENOG4107QIM DNA ligase HUT12_RS26200 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HUT12_RS26215 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HUT12_RS26220 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) HUT12_RS26225 ENOG4105VHU single-stranded DNA-binding protein HUT12_RS26265 ENOG4105D8V Glucose sorbosone dehydrogenase HUT12_RS26280 ENOG4105WH1 Two component transcriptional regulator luxr family HUT12_RS26290 ENOG4105E9Q Acyl-transferase HUT12_RS26335 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HUT12_RS26365 ENOG4105XM7 Lipoprotein lprD HUT12_RS26390 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HUT12_RS26395 ENOG4106KNT transcriptional regulator HUT12_RS26405 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) HUT12_RS26430 ENOG4105KAV tspo and mbr like protein HUT12_RS26435 ENOG4105EPJ extracellular solute-binding protein family 1 HUT12_RS26440 ENOG4105S9S Binding-protein-dependent transport systems, inner membrane component HUT12_RS26445 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component HUT12_RS26450 ENOG4105ETE Transcriptional regulator (LacI family HUT12_RS26455 ENOG4105CG3 alpha amylase, catalytic region HUT12_RS26460 ENOG4105CZQ inner membrane transport protein YdhC HUT12_RS26495 ENOG4105D3Q Sugar transferase HUT12_RS26545 ENOG41065HY 1,4-beta-cellobiosidase HUT12_RS26560 ENOG4105C7I Dehydrogenase HUT12_RS26595 ENOG4105CHU acetyl-coa acetyltransferase HUT12_RS26645 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HUT12_RS26650 ENOG4105Q36 FHA domain containing protein HUT12_RS26665 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) HUT12_RS26685 ENOG4105CJ1 ABC, transporter HUT12_RS26695 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HUT12_RS26700 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HUT12_RS26715 ENOG4108TCJ secreted hydrolase HUT12_RS26725 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) HUT12_RS26735 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) HUT12_RS26740 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) HUT12_RS26745 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) HUT12_RS26750 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HUT12_RS26755 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) HUT12_RS26760 ENOG4106DE0 ATP synthase HUT12_RS26765 ENOG4107UH5 it plays a direct role in the translocation of protons across the membrane (By similarity) HUT12_RS26780 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HUT12_RS26785 ENOG4105CGD Nad-dependent epimerase dehydratase HUT12_RS26790 ENOG4105BZ4 penicillin-binding protein HUT12_RS26795 ENOG4105KJF protein tyrosine phosphatase HUT12_RS26800 ENOG4107UIY sua5 ycio yrdc ywlc family protein HUT12_RS26805 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HUT12_RS26810 ENOG4105BZU Histidine kinase HUT12_RS26815 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) HUT12_RS26820 ENOG4105VFB Binds the 23S rRNA (By similarity) HUT12_RS26830 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) HUT12_RS26855 ENOG4105YIP Tetr family transcriptional regulator HUT12_RS26865 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) HUT12_RS26870 ENOG4105D6E homoserine dehydrogenase HUT12_RS26875 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HUT12_RS26880 ENOG4105C75 arginyL-tRNA synthetase HUT12_RS26920 ENOG4105DQE DNA ligase HUT12_RS26935 ENOG4105EYF MMPL domain protein HUT12_RS26970 ENOG4105CG3 alpha amylase, catalytic region HUT12_RS26980 ENOG4107T5V SNARE associated Golgi HUT12_RS26995 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) HUT12_RS27000 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase HUT12_RS27055 ENOG4105CIK Amidinotransferase HUT12_RS27060 ENOG4105C8Y Acetylornithine aminotransferase HUT12_RS27070 ENOG410842T Pterin carbinolamine dehydratase HUT12_RS27095 ENOG4107TPY serine threonine protein kinase HUT12_RS27110 ENOG4105C0H protease HUT12_RS27115 ENOG4105BZU Histidine kinase HUT12_RS27120 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUT12_RS27140 ENOG4105CJ1 ABC, transporter HUT12_RS27150 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HUT12_RS27160 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) HUT12_RS27175 ENOG4105C6K Malic enzyme HUT12_RS27180 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HUT12_RS27215 ENOG4108VEQ Superoxide dismutase HUT12_RS27220 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) HUT12_RS27230 ENOG4105CBD Diacylglycerol kinase HUT12_RS27245 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) HUT12_RS27270 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HUT12_RS27285 ENOG4107XI7 Tetr family transcriptional regulator HUT12_RS27295 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit HUT12_RS27300 ENOG4105WMN AntiSigma factor HUT12_RS27305 ENOG4105EMN RNA polymerase sigma factor HUT12_RS27325 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HUT12_RS27335 ENOG4107TK4 histidinol-phosphate phosphatase HUT12_RS27345 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HUT12_RS27360 ENOG4105ENE Histidine kinase HUT12_RS27370 ENOG4105C8V SAICAR synthetase HUT12_RS27390 ENOG4105DJZ UPF0182 protein HUT12_RS27395 ENOG41063PX domain protein HUT12_RS27435 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HUT12_RS27495 ENOG4105VEQ Cold shock protein HUT12_RS27510 ENOG4108URH decarboxylase HUT12_RS27515 ENOG4108URH decarboxylase HUT12_RS27525 ENOG4107R4C succinyl-diaminopimelate desuccinylase HUT12_RS27530 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) HUT12_RS27540 ENOG4108UW5 maltose o-acetyltransferase HUT12_RS27560 ENOG4105EVN Prephenate dehydrogenase HUT12_RS27570 ENOG4108Z4U Ferredoxin HUT12_RS27590 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) HUT12_RS27615 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HUT12_RS27635 ENOG4105KZX Pterin carbinolamine dehydratase HUT12_RS27645 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HUT12_RS27650 ENOG4108UB4 uncharacterized protein ygjQ HUT12_RS27665 ENOG4105C3G gtp-binding protein HUT12_RS27680 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HUT12_RS27685 ENOG4105BZ1 (ABC) transporter HUT12_RS27690 ENOG4105BZ1 (ABC) transporter HUT12_RS27695 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HUT12_RS27715 ENOG4105DA5 (ABC) transporter HUT12_RS27725 ENOG4107T1U Catalyzes the synthesis of activated sulfate (By similarity) HUT12_RS27730 ENOG4105N2W Transcriptional regulator HUT12_RS27760 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HUT12_RS27765 ENOG4105DEF Extracellular solute-binding protein, family 5 HUT12_RS27770 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HUT12_RS27775 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT12_RS27780 ENOG4105C3U ABC transporter HUT12_RS27785 ENOG4108JQ7 (ABC) transporter HUT12_RS27790 ENOG4105DC1 bifunctional purine biosynthesis protein purh HUT12_RS27825 ENOG4105CMV Succinyl-CoA synthetase subunit beta HUT12_RS27835 ENOG4105DR5 peptidase HUT12_RS27840 ENOG4105E4C Lytic transglycosylase catalytic HUT12_RS27850 ENOG4106D2I Chorismate mutase HUT12_RS27855 ENOG4108JQ7 (ABC) transporter HUT12_RS27865 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT12_RS27870 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HUT12_RS27880 ENOG4105WH1 Two component transcriptional regulator luxr family HUT12_RS27885 ENOG4108XG2 Histidine kinase HUT12_RS27900 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme HUT12_RS27905 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase HUT12_RS27915 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HUT12_RS27925 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HUT12_RS27935 ENOG4108KGH TRANSCRIPTIONal HUT12_RS27945 ENOG4107QVP Dehydrogenase HUT12_RS27960 ENOG4105WH1 Two component transcriptional regulator luxr family HUT12_RS27965 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HUT12_RS27975 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) HUT12_RS27980 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) HUT12_RS28000 ENOG4108Z66 YbaK ebsC protein HUT12_RS28010 ENOG4105C2J ABC transporter HUT12_RS28015 ENOG4108HWW ABC transporter HUT12_RS28040 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HUT12_RS28055 ENOG4108MMM RNA Polymerase HUT12_RS28070 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) HUT12_RS28075 ENOG4108097 ATP-binding protein HUT12_RS28085 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HUT12_RS28105 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HUT12_RS28115 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) HUT12_RS28120 ENOG4108UJD 30S ribosomal protein S9 HUT12_RS28125 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) HUT12_RS28130 ENOG4105DQQ Major facilitator superfamily MFS_1 HUT12_RS28145 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) HUT12_RS28150 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HUT12_RS28155 ENOG4108IFG nitrite reductase, (NAD(P)H) HUT12_RS28160 ENOG4107QZF nitrite reductase NADPH large subunit HUT12_RS28165 ENOG4107QZF nitrite reductase NADPH large subunit HUT12_RS28185 ENOG4105GWZ Roadblock lc7 family protein HUT12_RS28200 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HUT12_RS28230 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) HUT12_RS28240 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) HUT12_RS28245 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) HUT12_RS28255 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) HUT12_RS28270 ENOG4105CPC Aldo Keto reductase HUT12_RS28280 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) HUT12_RS28290 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) HUT12_RS28295 ENOG4108ZT0 50S ribosomal protein l17 HUT12_RS28300 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HUT12_RS28305 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) HUT12_RS28310 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) HUT12_RS28315 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits HUT12_RS28320 ENOG41067V7 50S ribosomal protein L36 HUT12_RS28325 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HUT12_RS28340 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) HUT12_RS28345 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HUT12_RS28350 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) HUT12_RS28355 ENOG410849U 50S ribosomal protein L30 HUT12_RS28360 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) HUT12_RS28365 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) HUT12_RS28370 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) HUT12_RS28375 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) HUT12_RS28380 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HUT12_RS28385 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits HUT12_RS28390 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HUT12_RS28395 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) HUT12_RS28400 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal HUT12_RS28405 ENOG41082SA 50s ribosomal protein l29 HUT12_RS28410 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) HUT12_RS28415 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) HUT12_RS28420 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) HUT12_RS28425 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) HUT12_RS28430 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity HUT12_RS28435 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) HUT12_RS28440 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) HUT12_RS28445 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) HUT12_RS28450 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) HUT12_RS28455 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HUT12_RS28460 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HUT12_RS28465 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) HUT12_RS28470 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) HUT12_RS28485 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HUT12_RS28490 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HUT12_RS28495 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) HUT12_RS28500 ENOG4108VZM 50s ribosomal protein L10 HUT12_RS28510 ENOG4105DIK (ABC) transporter HUT12_RS28515 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) HUT12_RS28520 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) HUT12_RS28545 ENOG410900P UPF0336 protein HUT12_RS28550 ENOG4105WDJ 50S ribosomal protein L33 HUT12_RS28580 ENOG4108VPT UPF0234 protein HUT12_RS28585 ENOG4105E1F short-chain dehydrogenase reductase HUT12_RS28590 ENOG4108JGH Tetr family transcriptional regulator HUT12_RS28600 ENOG4105D0M Protease HtpX homolog HUT12_RS28620 ENOG41082X4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT12_RS28625 ENOG4107YX3 NADH dehydrogenase subunit j HUT12_RS28630 ENOG4108M11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT12_RS28635 ENOG4105CHF Glutathione S-transferase HUT12_RS28640 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) HUT12_RS28645 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HUT12_RS28650 ENOG4105CPQ Dehydrogenase HUT12_RS28660 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT12_RS28670 ENOG4105CT4 transporter HUT12_RS28680 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HUT12_RS28685 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) HUT12_RS28735 ENOG4105C1J atp-dependent rna helicase HUT12_RS28755 ENOG4105C9U ATP-dependent DNA helicase RecQ HUT12_RS28765 ENOG4105CZN Potassium uptake protein HUT12_RS28770 ENOG4107ZYR domain protein HUT12_RS28775 ENOG4107QPV Serine Threonine protein kinase HUT12_RS28790 ENOG4105ECY inositol monophosphatase HUT12_RS28800 ENOG4105BZU Histidine kinase HUT12_RS28805 ENOG4105EEX Two component transcriptional regulator (Winged helix family HUT12_RS28810 ENOG4105IIU Aminopeptidase HUT12_RS28835 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HUT12_RS28860 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HUT12_RS28870 ENOG4105D52 delta-aminolevulinic acid dehydratase HUT12_RS28875 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HUT12_RS28880 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HUT12_RS28885 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) HUT12_RS28890 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) HUT12_RS28905 ENOG4105CEY Amp-dependent synthetase and ligase HUT12_RS28920 ENOG4108RXW HAD-superfamily subfamily IB hydrolase HUT12_RS28945 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT12_RS28950 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT12_RS29000 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) HUT12_RS29020 ENOG4105DSE periplasmic solute binding protein HUT12_RS29025 ENOG4105DIK (ABC) transporter HUT12_RS29055 ENOG4108SU4 UPF0309 protein HUT12_RS29070 ENOG4108PJD permease HUT12_RS29075 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein HUT12_RS29080 ENOG4108JJB ABC transporter HUT12_RS29095 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HUT12_RS29105 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HUT12_RS29110 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) HUT12_RS29125 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HUT12_RS29140 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) HUT12_RS29155 ENOG4105K59 histidine triad (HIT) protein HUT12_RS29170 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HUT12_RS29175 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) HUT12_RS29190 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase HUT12_RS29215 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component HUT12_RS29235 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) HUT12_RS29250 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) HUT12_RS29265 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 HUT12_RS29270 ENOG4105KQC Competence protein HUT12_RS29275 ENOG4105CHR reductase HUT12_RS29280 ENOG4105EPR degv family HUT12_RS29285 ENOG4105CVJ phosphoglycerate mutase HUT12_RS29290 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) HUT12_RS29295 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) HUT12_RS29315 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HUT12_RS29320 ENOG4105K46 50S ribosomal protein l27 HUT12_RS29325 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) HUT12_RS29330 ENOG4105C03 ribonuclease HUT12_RS29350 ENOG4105F6E Acyl-transferase HUT12_RS29355 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HUT12_RS29360 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HUT12_RS29365 ENOG4108KPJ rna polymerase sigma factor HUT12_RS29370 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) HUT12_RS29385 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HUT12_RS29390 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HUT12_RS29430 ENOG4106032 Glutathionylspermidine synthase HUT12_RS29440 ENOG4105EY0 Xylose isomerase domain protein TIM barrel HUT12_RS29445 ENOG4107R33 ppx gppa phosphatase HUT12_RS29450 ENOG4108JWX HUT12_RS29470 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HUT12_RS29495 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HUT12_RS29505 ENOG4107R4N Cell wall formation (By similarity) HUT12_RS29525 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component HUT12_RS29535 ENOG4105ETE Transcriptional regulator (LacI family HUT12_RS29540 ENOG4105KME endoribonuclease L-psp HUT12_RS29555 ENOG4105DTA methyltransferase HUT12_RS29580 ENOG4105BZU Histidine kinase HUT12_RS29585 ENOG4105WH1 Two component transcriptional regulator luxr family HUT12_RS29600 ENOG4105C1J atp-dependent rna helicase HUT12_RS29650 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) HUT12_RS29655 ENOG4105I3K Ferric uptake regulator, Fur family HUT12_RS29665 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands HUT12_RS29710 ENOG4105PKJ carbohydrate binding HUT12_RS29715 ENOG4105KHC sulfurtransferase HUT12_RS29730 ENOG4107NHD transcriptional regulator HUT12_RS29740 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HUT12_RS29765 ENOG4105CSR polyphosphate kinase 2 HUT12_RS29795 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) HUT12_RS29815 ENOG4105CQB FAD linked oxidase domain protein HUT12_RS29845 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) HUT12_RS29855 ENOG4105VEQ Cold shock protein HUT12_RS29870 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HUT12_RS29875 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) HUT12_RS29895 ENOG4105CJ1 ABC, transporter HUT12_RS29910 ENOG4105GWZ Roadblock lc7 family protein HUT12_RS29935 ENOG4107TCE N-acetyltransferase HUT12_RS29955 ENOG4105CJ1 ABC, transporter HUT12_RS29960 ENOG4105E98 transcriptional regulator DeoR family HUT12_RS29965 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HUT12_RS29970 ENOG4105DKQ ROK family HUT12_RS29975 ENOG4105CE4 GlcNAc 6-P deacetylase HUT12_RS30015 ENOG4105K64 Glycosyl transferase, family 2 HUT12_RS30020 ENOG4107T8Q Glycosyl transferase (Group 1 HUT12_RS30045 ENOG4105C2N RNA methyltransferase TrmH family group 3 HUT12_RS30050 ENOG4105C8N cysteinyl-tRNA synthetase HUT12_RS30065 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin HUT12_RS30085 ENOG4105C9Q fumarate hydratase class II HUT12_RS30095 ENOG4107GFK fumarate HUT12_RS30120 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase HUT12_RS30135 ENOG4105CIH Imidazole acetol-phosphate transaminase HUT12_RS30170 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) HUT12_RS30175 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) HUT12_RS30210 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HUT12_RS30225 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HUT12_RS30230 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) HUT12_RS30240 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HUT12_RS30245 ENOG4105VUC UPF0237 protein HUT12_RS30270 ENOG4105CRK lysyL-tRNA synthetase HUT12_RS30280 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) HUT12_RS30290 ENOG4108IYU L-aspartate oxidase HUT12_RS30300 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) HUT12_RS30305 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) HUT12_RS30320 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT12_RS30335 ENOG4105E90 ABC transporter HUT12_RS30340 ENOG4105E90 ABC transporter HUT12_RS30410 ENOG4105E4C Lytic transglycosylase catalytic HUT12_RS30435 ENOG4105EUJ GTP cyclohydrolase i HUT12_RS30440 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HUT12_RS30455 ENOG4105ECQ AraC Family Transcriptional Regulator HUT12_RS30460 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HUT12_RS30465 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HUT12_RS30480 ENOG4105F0N pyrophosphate phospho-hydrolase HUT12_RS30490 ENOG4105EC2 ftsk spoIIIe HUT12_RS30500 ENOG4105YVM Phosphoesterase, PA-phosphatase related HUT12_RS30510 ENOG4105P8F nudix hydrolase HUT12_RS30515 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HUT12_RS30520 ENOG4105CSM endonuclease III HUT12_RS30555 ENOG4105C1G acyl-Coa dehydrogenase HUT12_RS30560 ENOG4107QX3 carboxylase HUT12_RS30605 ENOG4105F8J Adenylate Guanylate cyclase HUT12_RS30610 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HUT12_RS30645 ENOG4105N0U Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HUT12_RS30650 ENOG4105BZ4 penicillin-binding protein HUT12_RS30655 ENOG4105KTH gatB Yqey HUT12_RS30660 ENOG4105DIN metallophosphoesterase HUT12_RS30690 ENOG4105N14 lysine exporter protein LysE YggA HUT12_RS30720 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HUT12_RS30725 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) HUT12_RS30740 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HUT12_RS30765 ENOG4105BZU Histidine kinase HUT12_RS30775 ENOG4105CFH Aspartokinase HUT12_RS30790 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HUT12_RS30810 ENOG4108JQ7 (ABC) transporter HUT12_RS30815 ENOG4105C3U ABC transporter HUT12_RS30820 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT12_RS30825 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HUT12_RS30830 ENOG4105DEF Extracellular solute-binding protein, family 5 HUT12_RS30835 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) HUT12_RS30840 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) HUT12_RS30930 ENOG4105D3A purine nucleoside phosphorylase DeoD-type HUT12_RS30945 ENOG4108Z6B deaminase HUT12_RS30975 ENOG4105DCG PHP domain protein HUT12_RS30990 ENOG4108M6P methyltransferase HUT12_RS30995 ENOG41073B4 coagulation factor 5 8 type domain-containing protein HUT12_RS31005 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) HUT12_RS31125 ENOG4105EC2 ftsk spoIIIe HUT12_RS31140 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HUT12_RS31165 ENOG4106F1P AAA ATPase, central domain protein HUT12_RS31220 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HUT12_RS31250 ENOG4105ECY inositol monophosphatase HUT12_RS31270 ENOG4105CGH 5'-nucleotidase HUT12_RS31285 ENOG4105CUX Signal transduction histidine kinase HUT12_RS31315 ENOG4105XEA Tetr family transcriptional regulator HUT12_RS31400 ENOG4105EXC Acyl-transferase HUT12_RS31450 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HUT12_RS31470 ENOG4108V1U phospholipid-binding protein HUT12_RS31490 ENOG4108Z4X TRANSCRIPTIONal HUT12_RS31505 ENOG4105CKK Glycosyl transferase, family 2 HUT12_RS31530 ENOG4105CHU acetyl-coa acetyltransferase HUT12_RS31555 ENOG4105D7N magnesium and cobalt transport protein CorA HUT12_RS31560 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HUT12_RS31585 ENOG4108MDK Dehydrogenase HUT12_RS31605 ENOG4105D3Q Sugar transferase HUT12_RS31610 ENOG4108HRK Histidine kinase HUT12_RS31670 ENOG4107QN1 sodium solute HUT12_RS31675 ENOG4105C1B dTDP-glucose 4-6-dehydratase HUT12_RS31705 ENOG4105BZU Histidine kinase HUT12_RS31720 ENOG4105CEU Arginine dihydrolase HUT12_RS31740 ENOG4105CQC Prephenate dehydratase HUT12_RS31755 ENOG4108Z9K Osmotically inducible protein HUT12_RS31765 ENOG4105J7I hydrolase HUT12_RS31770 ENOG4108KP7 hydrolase HUT12_RS31775 ENOG4108VC7 Protein of unknown function (DUF2587) HUT12_RS31790 ENOG4105CIK Amidinotransferase HUT12_RS31820 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HUT12_RS31850 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HUT12_RS31860 ENOG4107RN3 metallophosphoesterase HUT12_RS31905 ENOG4108RIR Molybdenum cofactor biosynthesis protein HUT12_RS31910 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HUT12_RS31920 ENOG4105BZU Histidine kinase HUT12_RS31940 ENOG4105CDU Replicative dna helicase HUT12_RS31950 ENOG4105K9Q Binds to the 23S rRNA (By similarity) HUT12_RS31955 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HUT12_RS31965 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) HUT12_RS31985 ENOG4105BZ4 penicillin-binding protein HUT12_RS32000 ENOG4105CZA synthase HUT12_RS32005 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HUT12_RS32010 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin HUT12_RS32015 ENOG4105DJ0 Poly(A) Polymerase HUT12_RS32040 ENOG4105C3M thioredoxin reductase HUT12_RS32045 ENOG4105K63 Thioredoxin HUT12_RS32050 ENOG4108E1C hydrolase HUT12_RS32060 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HUT12_RS32065 ENOG4105CPF Cell wall formation (By similarity) HUT12_RS32080 ENOG4107QJE Chromosome Partitioning Protein HUT12_RS32085 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) HUT12_RS32095 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HUT12_RS32100 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) HUT12_RS32110 ENOG41084CH 50S ribosomal protein l34 HUT12_RS32120 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HUT12_RS32125 ENOG4108J5G 6-phosphogluconate dehydrogenase HUT12_RS32130 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HUT12_RS32135 ENOG4105K7N UPF0232 protein HUT12_RS32145 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HUT12_RS32255 ENOG4105DR5 peptidase HUT12_RS32400 ENOG4107414 GntR family transcriptional regulator HUT12_RS32445 ENOG4107QZI cell division protein FtsK