locus-tag	class	description
HUT12_RS00005	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HUT12_RS00005	COG1372	Participates in initiation and elongation during chromosome replication
HUT12_RS00025	COG1028	Short-chain dehydrogenase reductase Sdr
HUT12_RS00035	COG0009	L-threonylcarbamoyladenylate synthase
HUT12_RS00040	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HUT12_RS00085	COG0517	IMP dehydrogenase activity
HUT12_RS00090	COG0442	prolyl-tRNA aminoacylation
HUT12_RS00095	COG2197	response regulator
HUT12_RS00100	COG4585	Histidine kinase
HUT12_RS00115	COG0596	Alpha beta hydrolase
HUT12_RS00150	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUT12_RS00155	COG0326	Molecular chaperone. Has ATPase activity
HUT12_RS00170	COG0439	Biotin carboxylase
HUT12_RS00175	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HUT12_RS00180	COG0667	Aldo Keto reductase
HUT12_RS00215	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUT12_RS00235	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HUT12_RS00240	COG1960	acyl-CoA dehydrogenase activity
HUT12_RS00260	COG2353	YceI-like domain
HUT12_RS00275	COG2815	serine threonine protein kinase
HUT12_RS00275	COG0515	serine threonine protein kinase
HUT12_RS00335	COG1716	ATPase activity
HUT12_RS00335	COG1716	ATPase activity
HUT12_RS00340	COG1716	ATPase activity
HUT12_RS00355	COG0768	penicillin binding
HUT12_RS00360	COG0515	serine threonine protein kinase
HUT12_RS00365	COG0515	serine threonine protein kinase
HUT12_RS00365	COG2815	serine threonine protein kinase
HUT12_RS00405	COG2181	nitrate reductase activity
HUT12_RS00405	COG0247	lactate metabolic process
HUT12_RS00410	COG0791	NLP P60 protein
HUT12_RS00420	COG0717	Belongs to the dCTP deaminase family
HUT12_RS00450	COG0546	phosphoglycolate phosphatase activity
HUT12_RS00490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT12_RS00505	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HUT12_RS00510	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HUT12_RS00520	COG1960	acyl-CoA dehydrogenase activity
HUT12_RS00530	COG2062	phosphohistidine phosphatase, SixA
HUT12_RS00555	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HUT12_RS00575	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUT12_RS00580	COG0022	dehydrogenase e1 component
HUT12_RS00625	COG0443	Heat shock 70 kDa protein
HUT12_RS00630	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HUT12_RS00635	COG0484	heat shock protein binding
HUT12_RS00640	COG0789	Transcriptional regulator
HUT12_RS00675	COG0542	response to heat
HUT12_RS00705	COG1028	Short-chain dehydrogenase reductase Sdr
HUT12_RS00715	COG0640	Transcriptional regulator
HUT12_RS00725	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HUT12_RS00740	COG1950	PFAM Membrane protein of
HUT12_RS00745	COG0191	fructose-bisphosphate aldolase activity
HUT12_RS00770	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HUT12_RS00785	COG0151	Belongs to the GarS family
HUT12_RS00820	COG0318	PFAM AMP-dependent synthetase and ligase
HUT12_RS00825	COG1960	acyl-CoA dehydrogenase activity
HUT12_RS00835	COG1309	transcriptional regulator
HUT12_RS00845	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HUT12_RS00865	COG2030	dehydratase
HUT12_RS00870	COG1028	Short-chain dehydrogenase reductase Sdr
HUT12_RS00875	COG0183	Belongs to the thiolase family
HUT12_RS00880	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HUT12_RS00885	COG0393	Putative heavy-metal-binding
HUT12_RS00895	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HUT12_RS00900	COG0047	phosphoribosylformylglycinamidine synthase activity
HUT12_RS00905	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HUT12_RS00930	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HUT12_RS00935	COG0641	radical SAM
HUT12_RS00980	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUT12_RS00985	COG1024	Enoyl-CoA hydratase
HUT12_RS01035	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HUT12_RS01065	COG1609	Transcriptional regulator
HUT12_RS01070	COG1653	transport
HUT12_RS01075	COG1175	transmembrane transport
HUT12_RS01080	COG0395	ABC-type sugar transport system, permease component
HUT12_RS01085	COG0366	Alpha amylase catalytic
HUT12_RS01185	COG4585	Histidine kinase
HUT12_RS01200	COG2197	response regulator
HUT12_RS01205	COG2091	lysine biosynthetic process via aminoadipic acid
HUT12_RS01235	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUT12_RS01255	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUT12_RS01255	COG3320	Male sterility
HUT12_RS01335	COG1116	anion transmembrane transporter activity
HUT12_RS01350	COG4566	intracellular signal transduction
HUT12_RS01360	COG3135	benzoate transporter
HUT12_RS01375	COG1970	mechanosensitive ion channel activity
HUT12_RS01380	COG2186	Transcriptional regulator
HUT12_RS01385	COG2807	transmembrane transport
HUT12_RS01395	COG1366	Belongs to the anti-sigma-factor antagonist family
HUT12_RS01400	COG1366	Belongs to the anti-sigma-factor antagonist family
HUT12_RS01405	COG2172	sigma factor antagonist activity
HUT12_RS01415	COG2205	protein histidine kinase activity
HUT12_RS01420	COG0745	RESPONSE REGULATOR receiver
HUT12_RS01450	COG1136	(ABC) transporter
HUT12_RS01465	COG0277	FAD linked oxidase domain protein
HUT12_RS01490	COG0151	Belongs to the GarS family
HUT12_RS01525	COG0318	PFAM AMP-dependent synthetase and ligase
HUT12_RS01530	COG1960	acyl-CoA dehydrogenase activity
HUT12_RS01540	COG1309	transcriptional regulator
HUT12_RS01550	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HUT12_RS01570	COG2030	dehydratase
HUT12_RS01575	COG1028	Short-chain dehydrogenase reductase Sdr
HUT12_RS01580	COG0183	Belongs to the thiolase family
HUT12_RS01585	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HUT12_RS01590	COG0393	Putative heavy-metal-binding
HUT12_RS01600	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HUT12_RS01605	COG0047	phosphoribosylformylglycinamidine synthase activity
HUT12_RS01610	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HUT12_RS01635	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HUT12_RS01640	COG0641	radical SAM
HUT12_RS01685	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUT12_RS01690	COG1024	Enoyl-CoA hydratase
HUT12_RS01740	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HUT12_RS01770	COG1609	Transcriptional regulator
HUT12_RS01775	COG1653	transport
HUT12_RS01780	COG1175	transmembrane transport
HUT12_RS01785	COG0395	ABC-type sugar transport system, permease component
HUT12_RS01790	COG0366	Alpha amylase catalytic
HUT12_RS01890	COG4585	Histidine kinase
HUT12_RS01905	COG2197	response regulator
HUT12_RS01910	COG2091	lysine biosynthetic process via aminoadipic acid
HUT12_RS01940	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUT12_RS01960	COG3320	Male sterility
HUT12_RS01960	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUT12_RS02040	COG1116	anion transmembrane transporter activity
HUT12_RS02055	COG4566	intracellular signal transduction
HUT12_RS02065	COG3135	benzoate transporter
HUT12_RS02080	COG1970	mechanosensitive ion channel activity
HUT12_RS02085	COG2186	Transcriptional regulator
HUT12_RS02090	COG2807	transmembrane transport
HUT12_RS02100	COG1366	Belongs to the anti-sigma-factor antagonist family
HUT12_RS02105	COG1366	Belongs to the anti-sigma-factor antagonist family
HUT12_RS02110	COG2172	sigma factor antagonist activity
HUT12_RS02120	COG2205	protein histidine kinase activity
HUT12_RS02125	COG0745	RESPONSE REGULATOR receiver
HUT12_RS02155	COG1136	(ABC) transporter
HUT12_RS02170	COG0277	FAD linked oxidase domain protein
HUT12_RS02180	COG2205	protein histidine kinase activity
HUT12_RS02180	COG0784	Response regulator, receiver
HUT12_RS02190	COG1366	Belongs to the anti-sigma-factor antagonist family
HUT12_RS02195	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HUT12_RS02200	COG0406	alpha-ribazole phosphatase activity
HUT12_RS02205	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUT12_RS02210	COG0785	Cytochrome C biogenesis protein
HUT12_RS02220	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HUT12_RS02250	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HUT12_RS02265	COG0163	prenyltransferase activity
HUT12_RS02275	COG1522	sequence-specific DNA binding
HUT12_RS02280	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HUT12_RS02290	COG0513	Belongs to the DEAD box helicase family
HUT12_RS02305	COG0791	NLP P60 protein
HUT12_RS02310	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HUT12_RS02330	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HUT12_RS02335	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUT12_RS02340	COG1120	ATPase activity
HUT12_RS02355	COG1131	(ABC) transporter
HUT12_RS02360	COG3973	AAA domain
HUT12_RS02365	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HUT12_RS02380	COG3396	Phenylacetate-CoA oxygenase
HUT12_RS02385	COG3460	Phenylacetate-CoA oxygenase
HUT12_RS02390	COG3396	Phenylacetate-CoA oxygenase
HUT12_RS02395	COG2151	metal-sulfur cluster biosynthetic enzyme
HUT12_RS02400	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HUT12_RS02410	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HUT12_RS02420	COG2226	methyltransferase
HUT12_RS02440	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUT12_RS02445	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUT12_RS02450	COG0649	NAD binding
HUT12_RS02465	COG1034	ATP synthesis coupled electron transport
HUT12_RS02475	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUT12_RS02485	COG0713	ATP synthesis coupled electron transport
HUT12_RS02500	COG1007	ATP synthesis coupled electron transport
HUT12_RS02590	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HUT12_RS02650	COG1674	ftsk spoiiie
HUT12_RS02745	COG1205	dead DEAH box helicase
HUT12_RS02745	COG1111	helicase
HUT12_RS02750	COG1366	Belongs to the anti-sigma-factor antagonist family
HUT12_RS02760	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HUT12_RS02775	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HUT12_RS02775	COG1754	DNA topoisomerase type I activity
HUT12_RS02785	COG1309	transcriptional regulator
HUT12_RS02795	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HUT12_RS02800	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HUT12_RS02820	COG1774	PSP1 C-terminal conserved region
HUT12_RS02860	COG3550	peptidyl-serine autophosphorylation
HUT12_RS02900	COG0693	protein deglycase activity
HUT12_RS02915	COG1063	alcohol dehydrogenase
HUT12_RS02920	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUT12_RS02930	COG0545	Peptidyl-prolyl cis-trans isomerase
HUT12_RS02935	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HUT12_RS02940	COG3285	dna ligase
HUT12_RS02940	COG1793	dna ligase
HUT12_RS02945	COG3285	dna ligase
HUT12_RS02945	COG1793	dna ligase
HUT12_RS02975	COG1061	Type III restriction enzyme res subunit
HUT12_RS02995	COG1278	Cold shock
HUT12_RS03000	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HUT12_RS03010	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HUT12_RS03015	COG2814	Major facilitator Superfamily
HUT12_RS03030	COG2252	PERMEase
HUT12_RS03040	COG2814	Major facilitator Superfamily
HUT12_RS03055	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HUT12_RS03065	COG0259	pyridoxamine-phosphate oxidase activity
HUT12_RS03075	COG2017	converts alpha-aldose to the beta-anomer
HUT12_RS03090	COG1960	acyl-CoA dehydrogenase activity
HUT12_RS03105	COG1760	l-serine dehydratase
HUT12_RS03125	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HUT12_RS03130	COG3842	ATPase activity
HUT12_RS03230	COG1937	Protein conserved in bacteria
HUT12_RS03250	COG3237	CsbD-like
HUT12_RS03265	COG3387	PFAM Glycoside hydrolase 15-related
HUT12_RS03280	COG1742	UPF0060 membrane protein
HUT12_RS03290	COG1132	(ABC) transporter
HUT12_RS03305	COG2837	iron assimilation
HUT12_RS03335	COG2217	Heavy metal translocating P-type atpase
HUT12_RS03355	COG1309	transcriptional regulator
HUT12_RS03360	COG0667	Aldo Keto reductase
HUT12_RS03370	COG2197	response regulator
HUT12_RS03380	COG1131	(ABC) transporter
HUT12_RS03485	COG1674	ftsk spoiiie
HUT12_RS03490	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HUT12_RS03520	COG1404	Belongs to the peptidase S8 family
HUT12_RS03525	COG0464	growth
HUT12_RS03545	COG0702	epimerase
HUT12_RS03555	COG0740	serine-type endopeptidase activity
HUT12_RS03565	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HUT12_RS03570	COG1846	Transcriptional regulator
HUT12_RS03575	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HUT12_RS03580	COG1013	pyruvate-flavodoxin oxidoreductase activity
HUT12_RS03585	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HUT12_RS03585	COG0674	pyruvate-flavodoxin oxidoreductase activity
HUT12_RS03590	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUT12_RS03595	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HUT12_RS03620	COG0519	Catalyzes the synthesis of GMP from XMP
HUT12_RS03630	COG1024	Enoyl-CoA hydratase
HUT12_RS03645	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HUT12_RS03650	COG4122	O-methyltransferase activity
HUT12_RS03655	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUT12_RS03660	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HUT12_RS03675	COG2239	Acts as a magnesium transporter
HUT12_RS03680	COG0384	phenazine biosynthesis protein PhzF
HUT12_RS03745	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUT12_RS03775	COG1595	DNA-templated transcription, initiation
HUT12_RS03785	COG0613	PHP domain protein
HUT12_RS03790	COG2095	MarC family integral membrane protein
HUT12_RS03830	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HUT12_RS03840	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HUT12_RS03845	COG0303	'Molybdopterin
HUT12_RS03865	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HUT12_RS03875	COG0640	Transcriptional regulator
HUT12_RS03910	COG1028	Short-chain dehydrogenase reductase Sdr
HUT12_RS03915	COG1196	nuclear chromosome segregation
HUT12_RS03915	COG0741	lytic transglycosylase activity
HUT12_RS03915	COG0739	heme binding
HUT12_RS03940	COG3940	Belongs to the glycosyl hydrolase 43 family
HUT12_RS03990	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUT12_RS03995	COG2267	carboxylic ester hydrolase activity
HUT12_RS04005	COG0084	hydrolase, TatD family'
HUT12_RS04010	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HUT12_RS04015	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HUT12_RS04020	COG0488	(ABC) transporter
HUT12_RS04055	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HUT12_RS04060	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HUT12_RS04065	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HUT12_RS04070	COG0193	aminoacyl-tRNA hydrolase activity
HUT12_RS04075	COG1218	3'(2'),5'-bisphosphate nucleotidase
HUT12_RS04090	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HUT12_RS04095	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HUT12_RS04105	COG0180	Tryptophanyl-tRNA synthetase
HUT12_RS04125	COG0366	Alpha amylase catalytic
HUT12_RS04145	COG3833	ABC-type maltose transport systems, permease component
HUT12_RS04195	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HUT12_RS04210	COG2018	Roadblock/LC7 domain
HUT12_RS04235	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HUT12_RS04240	COG4988	ABC transporter
HUT12_RS04255	COG1012	belongs to the aldehyde dehydrogenase family
HUT12_RS04260	COG1012	belongs to the aldehyde dehydrogenase family
HUT12_RS04265	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HUT12_RS04270	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HUT12_RS04290	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HUT12_RS04300	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUT12_RS04300	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUT12_RS04305	COG1473	amidohydrolase
HUT12_RS04305	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HUT12_RS04370	COG4770	biotin carboxylase activity
HUT12_RS04390	COG0424	maF-like protein
HUT12_RS04395	COG1404	Belongs to the peptidase S8 family
HUT12_RS04435	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HUT12_RS04460	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HUT12_RS04470	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HUT12_RS04475	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUT12_RS04475	COG1877	trehalose-phosphatase activity
HUT12_RS04500	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HUT12_RS04535	COG1722	exodeoxyribonuclease VII activity
HUT12_RS04540	COG1570	exodeoxyribonuclease VII activity
HUT12_RS04545	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HUT12_RS04560	COG1322	Protein conserved in bacteria
HUT12_RS04570	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HUT12_RS04620	COG0148	phosphopyruvate hydratase activity
HUT12_RS04635	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HUT12_RS04665	COG0714	Associated with various cellular activities
HUT12_RS04705	COG0183	Belongs to the thiolase family
HUT12_RS04735	COG0454	-acetyltransferase
HUT12_RS04735	COG0456	acetyltransferase
HUT12_RS04740	COG1234	tRNA 3'-trailer cleavage
HUT12_RS04745	COG1363	Peptidase, m42
HUT12_RS04750	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HUT12_RS04750	COG0189	ligase activity
HUT12_RS04755	COG0367	asparagine synthase
HUT12_RS04760	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUT12_RS04765	COG0537	adenosine 5'-monophosphoramidase activity
HUT12_RS04790	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HUT12_RS04795	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HUT12_RS04805	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HUT12_RS04820	COG1331	Highly conserved protein containing a thioredoxin domain
HUT12_RS04840	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HUT12_RS04870	COG3845	ABC transporter
HUT12_RS05005	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HUT12_RS05035	COG4762	Protein conserved in bacteria
HUT12_RS05060	COG4974	Belongs to the 'phage' integrase family
HUT12_RS05255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUT12_RS05270	COG1902	pentaerythritol trinitrate reductase activity
HUT12_RS05285	COG0604	alcohol dehydrogenase
HUT12_RS05290	COG3629	intracellular signal transduction
HUT12_RS05290	COG3903	Transcriptional regulator
HUT12_RS05305	COG0477	Major facilitator Superfamily
HUT12_RS05315	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT12_RS05335	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUT12_RS05340	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HUT12_RS05355	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HUT12_RS05365	COG1126	abc transporter atp-binding protein
HUT12_RS05370	COG0765	amino acid transport
HUT12_RS05375	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT12_RS05400	COG1028	Short-chain dehydrogenase reductase Sdr
HUT12_RS05430	COG0747	negative chemotaxis
HUT12_RS05450	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT12_RS05465	COG0318	PFAM AMP-dependent synthetase and ligase
HUT12_RS05470	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT12_RS05475	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT12_RS05485	COG1960	acyl-CoA dehydrogenase activity
HUT12_RS05490	COG0318	PFAM AMP-dependent synthetase and ligase
HUT12_RS05515	COG1028	Short-chain dehydrogenase reductase Sdr
HUT12_RS05520	COG0183	Belongs to the thiolase family
HUT12_RS05535	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUT12_RS05550	COG0747	negative chemotaxis
HUT12_RS05555	COG1024	Enoyl-CoA hydratase
HUT12_RS05595	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HUT12_RS05640	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HUT12_RS05680	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HUT12_RS05705	COG3842	ATPase activity
HUT12_RS05710	COG1176	ABC-type spermidine putrescine transport system, permease component I
HUT12_RS05715	COG1177	transmembrane transport
HUT12_RS05730	COG0010	Belongs to the arginase family
HUT12_RS05740	COG0745	RESPONSE REGULATOR receiver
HUT12_RS05745	COG2205	protein histidine kinase activity
HUT12_RS05755	COG1181	Belongs to the D-alanine--D-alanine ligase family
HUT12_RS05780	COG1012	belongs to the aldehyde dehydrogenase family
HUT12_RS05795	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HUT12_RS05800	COG2835	tetraacyldisaccharide 4'-kinase activity
HUT12_RS05820	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HUT12_RS05845	COG0714	Associated with various cellular activities
HUT12_RS05865	COG0745	RESPONSE REGULATOR receiver
HUT12_RS05885	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HUT12_RS05890	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HUT12_RS05900	COG0653	protein targeting
HUT12_RS05925	COG0506	proline dehydrogenase activity
HUT12_RS05925	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HUT12_RS05925	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HUT12_RS05935	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HUT12_RS05940	COG2884	Cell division ATP-binding protein ftsE
HUT12_RS05945	COG2177	Part of the ABC transporter FtsEX involved in
HUT12_RS05950	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HUT12_RS05970	COG1678	Uncharacterized ACR, COG1678
HUT12_RS06085	COG2070	2-Nitropropane dioxygenase
HUT12_RS06090	COG2814	Major facilitator Superfamily
HUT12_RS06100	COG1024	Enoyl-CoA hydratase
HUT12_RS06110	COG0318	PFAM AMP-dependent synthetase and ligase
HUT12_RS06120	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUT12_RS06135	COG1024	Enoyl-CoA hydratase
HUT12_RS06140	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT12_RS06145	COG2186	Transcriptional regulator
HUT12_RS06160	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUT12_RS06195	COG1960	acyl-CoA dehydrogenase activity
HUT12_RS06200	COG2301	Belongs to the HpcH HpaI aldolase family
HUT12_RS06215	COG1960	acyl-CoA dehydrogenase activity
HUT12_RS06230	COG3591	Belongs to the peptidase S1B family
HUT12_RS06235	COG0475	glutathione-regulated potassium exporter activity
HUT12_RS06245	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUT12_RS06265	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUT12_RS06305	COG3251	PFAM MbtH domain protein
HUT12_RS06315	COG1028	Short-chain dehydrogenase reductase Sdr
HUT12_RS06355	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HUT12_RS06360	COG0022	dehydrogenase e1 component
HUT12_RS06360	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUT12_RS06365	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HUT12_RS06390	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
HUT12_RS06415	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HUT12_RS06470	COG0789	Transcriptional regulator
HUT12_RS06495	COG2814	Major facilitator Superfamily
HUT12_RS06515	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HUT12_RS06595	COG0477	Major facilitator Superfamily
HUT12_RS06620	COG0656	L-ascorbic acid biosynthetic process
HUT12_RS06630	COG1192	Involved in chromosome partitioning
HUT12_RS06645	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HUT12_RS06690	COG4585	Histidine kinase
HUT12_RS06695	COG2197	response regulator
HUT12_RS06720	COG2234	aminopeptidase activity
HUT12_RS06770	COG2205	protein histidine kinase activity
HUT12_RS06775	COG0745	RESPONSE REGULATOR receiver
HUT12_RS06805	COG3387	PFAM Glycoside hydrolase 15-related
HUT12_RS06820	COG0656	L-ascorbic acid biosynthetic process
HUT12_RS06830	COG4733	cellulase activity
HUT12_RS06830	COG5297	Belongs to the glycosyl hydrolase family 6
HUT12_RS06835	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUT12_RS06840	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HUT12_RS06850	COG1335	isochorismatase
HUT12_RS06855	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HUT12_RS06860	COG2197	response regulator
HUT12_RS06870	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HUT12_RS06895	COG1234	tRNA 3'-trailer cleavage
HUT12_RS06905	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HUT12_RS06910	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HUT12_RS06915	COG2986	histidine ammonia-lyase
HUT12_RS06920	COG1228	amidohydrolase
HUT12_RS06930	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUT12_RS06935	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HUT12_RS06950	COG2755	lipolytic protein G-D-S-L family
HUT12_RS06950	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HUT12_RS06985	COG1316	TRANSCRIPTIONal
HUT12_RS07035	COG1122	ATPase activity
HUT12_RS07080	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HUT12_RS07090	COG0477	Major facilitator Superfamily
HUT12_RS07095	COG3226	Transcriptional regulator
HUT12_RS07100	COG1376	ErfK ybiS ycfS ynhG family protein
HUT12_RS07105	COG1376	ErfK ybiS ycfS ynhG family protein
HUT12_RS07115	COG2409	Drug exporters of the RND superfamily
HUT12_RS07125	COG0667	Aldo Keto reductase
HUT12_RS07135	COG0501	Belongs to the peptidase M48B family
HUT12_RS07165	COG2205	protein histidine kinase activity
HUT12_RS07240	COG1131	(ABC) transporter
HUT12_RS07245	COG1119	ATPase activity
HUT12_RS07250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUT12_RS07300	COG2149	membrane
HUT12_RS07320	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HUT12_RS07330	COG1595	DNA-templated transcription, initiation
HUT12_RS07350	COG0482	sulfurtransferase activity
HUT12_RS07370	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HUT12_RS07380	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HUT12_RS07385	COG0154	amidase activity
HUT12_RS07395	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HUT12_RS07400	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HUT12_RS07410	COG2133	pyrroloquinoline quinone binding
HUT12_RS07430	COG1609	Transcriptional regulator
HUT12_RS07520	COG0129	dihydroxy-acid dehydratase activity
HUT12_RS07525	COG5001	Diguanylate cyclase
HUT12_RS07525	COG3300	MHYT domain
HUT12_RS07535	COG0440	acetolactate synthase activity
HUT12_RS07540	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HUT12_RS07545	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HUT12_RS07560	COG0473	3-isopropylmalate dehydrogenase activity
HUT12_RS07565	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HUT12_RS07580	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HUT12_RS07595	COG0714	Associated with various cellular activities
HUT12_RS07605	COG2304	oxidoreductase activity
HUT12_RS07610	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUT12_RS07620	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HUT12_RS07660	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HUT12_RS07665	COG0066	3-isopropylmalate dehydratase activity
HUT12_RS07670	COG0776	regulation of translation
HUT12_RS07685	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HUT12_RS07695	COG1920	GTP binding
HUT12_RS07705	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HUT12_RS07710	COG0626	cystathionine gamma-synthase activity
HUT12_RS07715	COG2890	protein-(glutamine-N5) methyltransferase activity
HUT12_RS07720	COG1940	carbohydrate kinase activity
HUT12_RS07780	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HUT12_RS07785	COG1461	Dihydroxyacetone kinase
HUT12_RS07800	COG0742	ribosomal rna small subunit methyltransferase
HUT12_RS07805	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HUT12_RS07820	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HUT12_RS07825	COG0416	fatty acid biosynthetic process
HUT12_RS07830	COG0571	ribonuclease III activity
HUT12_RS07835	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HUT12_RS07845	COG2340	Cysteine-rich secretory protein family
HUT12_RS07890	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HUT12_RS07925	COG0442	prolyl-tRNA aminoacylation
HUT12_RS07935	COG0228	four-way junction DNA binding
HUT12_RS07940	COG1837	Belongs to the UPF0109 family
HUT12_RS07945	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HUT12_RS07950	COG0336	Belongs to the RNA methyltransferase TrmD family
HUT12_RS07955	COG0335	large ribosomal subunit rRNA binding
HUT12_RS07960	COG0681	Belongs to the peptidase S26 family
HUT12_RS07965	COG0681	Belongs to the peptidase S26 family
HUT12_RS07975	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HUT12_RS08000	COG4974	Belongs to the 'phage' integrase family
HUT12_RS08015	COG0792	nuclease activity
HUT12_RS08025	COG0052	Belongs to the universal ribosomal protein uS2 family
HUT12_RS08030	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HUT12_RS08035	COG0528	UMP kinase activity
HUT12_RS08040	COG0233	cytoplasmic translational termination
HUT12_RS08045	COG0575	Belongs to the CDS family
HUT12_RS08050	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HUT12_RS08065	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HUT12_RS08065	COG2146	nitrite reductase [NAD(P)H] activity
HUT12_RS08090	COG1515	deoxyribonuclease V activity
HUT12_RS08100	COG0750	zinc metalloprotease
HUT12_RS08105	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HUT12_RS08125	COG1902	pentaerythritol trinitrate reductase activity
HUT12_RS08135	COG0435	Glutathione S-transferase
HUT12_RS08140	COG0183	Belongs to the thiolase family
HUT12_RS08150	COG5001	Diguanylate cyclase
HUT12_RS08165	COG1012	belongs to the aldehyde dehydrogenase family
HUT12_RS08210	COG0577	efflux transmembrane transporter activity
HUT12_RS08210	COG1136	(ABC) transporter
HUT12_RS08230	COG0779	Required for maturation of 30S ribosomal subunits
HUT12_RS08245	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HUT12_RS08255	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HUT12_RS08260	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HUT12_RS08285	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HUT12_RS08295	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HUT12_RS08300	COG1185	polyribonucleotide nucleotidyltransferase activity
HUT12_RS08305	COG0612	Peptidase, M16
HUT12_RS08310	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HUT12_RS08315	COG1247	-acetyltransferase
HUT12_RS08330	COG3214	Protein conserved in bacteria
HUT12_RS08340	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HUT12_RS08345	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUT12_RS08350	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HUT12_RS08370	COG1674	ftsk spoiiie
HUT12_RS08390	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HUT12_RS08400	COG1546	Belongs to the CinA family
HUT12_RS08400	COG1058	Belongs to the CinA family
HUT12_RS08405	COG1396	sequence-specific DNA binding
HUT12_RS08420	COG1609	Transcriptional regulator
HUT12_RS08425	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HUT12_RS08440	COG0006	proline dipeptidase activity
HUT12_RS08445	COG1028	Short-chain dehydrogenase reductase Sdr
HUT12_RS08455	COG1176	ABC-type spermidine putrescine transport system, permease component I
HUT12_RS08465	COG3842	ATPase activity
HUT12_RS08470	COG2132	Multicopper oxidase
HUT12_RS08475	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HUT12_RS08500	COG1201	RNA secondary structure unwinding
HUT12_RS08510	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HUT12_RS08510	COG2111	Na H antiporter
HUT12_RS08530	COG2212	antiporter activity
HUT12_RS08535	COG1320	monovalent cation:proton antiporter activity
HUT12_RS08550	COG1253	flavin adenine dinucleotide binding
HUT12_RS08555	COG4326	sporulation control protein
HUT12_RS08575	COG1573	uracil-dna glycosylase
HUT12_RS08580	COG0477	Major facilitator Superfamily
HUT12_RS08590	COG1372	Participates in initiation and elongation during chromosome replication
HUT12_RS08590	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HUT12_RS08595	COG2137	regulation of response to DNA damage stimulus
HUT12_RS08600	COG1418	mRNA catabolic process
HUT12_RS08605	COG0765	amino acid transport
HUT12_RS08610	COG0765	amino acid transport
HUT12_RS08615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUT12_RS08620	COG1126	abc transporter atp-binding protein
HUT12_RS08640	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HUT12_RS08645	COG3866	Pectate lyase
HUT12_RS08650	COG1196	nuclear chromosome segregation
HUT12_RS08660	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HUT12_RS08665	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HUT12_RS08675	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HUT12_RS08690	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HUT12_RS08695	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HUT12_RS08730	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HUT12_RS08740	COG1490	D-aminoacyl-tRNA deacylase activity
HUT12_RS08745	COG2890	protein-(glutamine-N5) methyltransferase activity
HUT12_RS08755	COG3842	ATPase activity
HUT12_RS08760	COG1178	ABC-type Fe3 transport system permease component
HUT12_RS08765	COG1840	ABC-type Fe3 transport system, periplasmic component
HUT12_RS08785	COG2313	pseudouridylate synthase activity
HUT12_RS08795	COG2860	membrane
HUT12_RS08840	COG0756	dUTP diphosphatase activity
HUT12_RS08865	COG0569	domain protein
HUT12_RS08870	COG0531	amino acid
HUT12_RS08875	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HUT12_RS08880	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HUT12_RS08900	COG1802	Transcriptional regulator
HUT12_RS08910	COG1335	isochorismatase
HUT12_RS08940	COG0745	RESPONSE REGULATOR receiver
HUT12_RS08945	COG2205	protein histidine kinase activity
HUT12_RS08965	COG0183	Belongs to the thiolase family
HUT12_RS08970	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HUT12_RS08980	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HUT12_RS09020	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUT12_RS09040	COG1793	dna ligase
HUT12_RS09055	COG0438	transferase activity, transferring glycosyl groups
HUT12_RS09060	COG1216	Glycosyl transferase, family 2
HUT12_RS09060	COG1442	glycosyl transferase family 8
HUT12_RS09065	COG0438	transferase activity, transferring glycosyl groups
HUT12_RS09095	COG0419	ATPase involved in DNA repair
HUT12_RS09100	COG0420	3'-5' exonuclease activity
HUT12_RS09130	COG1175	transmembrane transport
HUT12_RS09135	COG0395	ABC-type sugar transport system, permease component
HUT12_RS09155	COG1960	acyl-CoA dehydrogenase activity
HUT12_RS09220	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HUT12_RS09225	COG0156	8-amino-7-oxononanoate synthase activity
HUT12_RS09230	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HUT12_RS09365	COG0464	growth
HUT12_RS09380	COG2197	response regulator
HUT12_RS09425	COG0726	polysaccharide deacetylase
HUT12_RS09440	COG1609	Transcriptional regulator
HUT12_RS09480	COG0589	response to stress
HUT12_RS09500	COG0542	response to heat
HUT12_RS09505	COG1597	lipid kinase activity
HUT12_RS09505	COG1803	Methylglyoxal synthase
HUT12_RS09515	COG0671	phosphoesterase, PA-phosphatase related
HUT12_RS09530	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT12_RS09540	COG4326	sporulation control protein
HUT12_RS09555	COG3973	AAA domain
HUT12_RS09580	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUT12_RS09665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUT12_RS09710	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUT12_RS09725	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HUT12_RS09725	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HUT12_RS09735	COG3304	Inner membrane component domain
HUT12_RS09775	COG1120	ATPase activity
HUT12_RS09800	COG1063	alcohol dehydrogenase
HUT12_RS09820	COG0187	DNA topoisomerase II activity
HUT12_RS09825	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HUT12_RS09835	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
HUT12_RS09850	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HUT12_RS09855	COG1086	Polysaccharide biosynthesis protein
HUT12_RS09875	COG1028	Short-chain dehydrogenase reductase Sdr
HUT12_RS09885	COG2089	acid synthase
HUT12_RS09890	COG1216	Glycosyl transferase, family 2
HUT12_RS09930	COG1134	teichoic acid transport
HUT12_RS09930	COG1388	LysM domain
HUT12_RS09940	COG1309	transcriptional regulator
HUT12_RS09965	COG5002	protein histidine kinase activity
HUT12_RS09970	COG2358	TRAP transporter, solute receptor (TAXI family
HUT12_RS09980	COG3022	response to hydroperoxide
HUT12_RS10000	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HUT12_RS10005	COG0366	Alpha amylase catalytic
HUT12_RS10020	COG0297	glycogen (starch) synthase activity
HUT12_RS10025	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HUT12_RS10035	COG1086	Polysaccharide biosynthesis protein
HUT12_RS10040	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HUT12_RS10045	COG0438	transferase activity, transferring glycosyl groups
HUT12_RS10065	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HUT12_RS10075	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HUT12_RS10110	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUT12_RS10120	COG0438	transferase activity, transferring glycosyl groups
HUT12_RS10140	COG1086	Polysaccharide biosynthesis protein
HUT12_RS10145	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HUT12_RS10165	COG2183	response to ionizing radiation
HUT12_RS10170	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HUT12_RS10190	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HUT12_RS10195	COG1053	succinate dehydrogenase
HUT12_RS10205	COG0583	DNA-binding transcription factor activity
HUT12_RS10210	COG1643	Atp-dependent helicase
HUT12_RS10235	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HUT12_RS10255	COG0708	Exodeoxyribonuclease III
HUT12_RS10285	COG1012	belongs to the aldehyde dehydrogenase family
HUT12_RS10290	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT12_RS10310	COG1643	Atp-dependent helicase
HUT12_RS10330	COG0531	amino acid
HUT12_RS10360	COG1741	Belongs to the pirin family
HUT12_RS10375	COG1233	COG1233 Phytoene dehydrogenase and related
HUT12_RS10420	COG1295	ribonuclease BN
HUT12_RS10440	COG0463	Glycosyl transferase, family 2
HUT12_RS10450	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HUT12_RS10460	COG0297	glycogen (starch) synthase activity
HUT12_RS10465	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HUT12_RS10470	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HUT12_RS10470	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HUT12_RS10515	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT12_RS10520	COG1472	Belongs to the glycosyl hydrolase 3 family
HUT12_RS10560	COG1278	Cold shock
HUT12_RS10570	COG0667	Aldo Keto reductase
HUT12_RS10575	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HUT12_RS10580	COG2205	protein histidine kinase activity
HUT12_RS10595	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HUT12_RS10615	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HUT12_RS10620	COG1560	Kdo2-lipid A biosynthetic process
HUT12_RS10625	COG0438	transferase activity, transferring glycosyl groups
HUT12_RS10635	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HUT12_RS10640	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HUT12_RS10660	COG0217	transcriptional regulatory protein
HUT12_RS10705	COG4152	abc transporter atp-binding protein
HUT12_RS10710	COG2197	response regulator
HUT12_RS10715	COG4585	Histidine kinase
HUT12_RS10720	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HUT12_RS10725	COG0501	Belongs to the peptidase M48B family
HUT12_RS10730	COG1704	LemA family
HUT12_RS10745	COG0587	DNA-directed DNA polymerase activity
HUT12_RS10765	COG0477	Major facilitator Superfamily
HUT12_RS10770	COG1309	transcriptional regulator
HUT12_RS10775	COG0586	Pfam SNARE associated Golgi protein
HUT12_RS10780	COG0387	Pfam Sodium calcium exchanger
HUT12_RS10785	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HUT12_RS10790	COG0632	four-way junction helicase activity
HUT12_RS10795	COG2255	four-way junction helicase activity
HUT12_RS10800	COG1862	Preprotein translocase
HUT12_RS10815	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HUT12_RS10820	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HUT12_RS10825	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HUT12_RS10840	COG0124	histidyl-tRNA synthetase
HUT12_RS10865	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HUT12_RS10885	COG0456	acetyltransferase
HUT12_RS10920	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HUT12_RS10925	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HUT12_RS10935	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HUT12_RS10955	COG0110	maltose O-acetyltransferase activity
HUT12_RS11000	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HUT12_RS11005	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HUT12_RS11010	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HUT12_RS11015	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HUT12_RS11020	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HUT12_RS11025	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HUT12_RS11035	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HUT12_RS11040	COG0540	Belongs to the ATCase OTCase family
HUT12_RS11045	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HUT12_RS11050	COG0505	Belongs to the CarA family
HUT12_RS11060	COG0167	dihydroorotate dehydrogenase activity
HUT12_RS11065	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HUT12_RS11070	COG0284	orotidine-5'-phosphate decarboxylase activity
HUT12_RS11080	COG0194	GDP metabolic process
HUT12_RS11085	COG1758	RNA polymerase activity
HUT12_RS11095	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HUT12_RS11100	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HUT12_RS11110	COG1102	Psort location Cytoplasmic, score
HUT12_RS11115	COG2124	cytochrome p450
HUT12_RS11120	COG0242	peptide deformylase activity
HUT12_RS11125	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HUT12_RS11150	COG0745	RESPONSE REGULATOR receiver
HUT12_RS11165	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HUT12_RS11165	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HUT12_RS11170	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HUT12_RS11195	COG1126	abc transporter atp-binding protein
HUT12_RS11200	COG0765	amino acid transport
HUT12_RS11205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUT12_RS11210	COG0140	phosphoribosyl-ATP diphosphatase activity
HUT12_RS11215	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HUT12_RS11230	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HUT12_RS11235	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HUT12_RS11240	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HUT12_RS11245	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HUT12_RS11250	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HUT12_RS11255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUT12_RS11255	COG0072	phenylalanine-tRNA ligase activity
HUT12_RS11260	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUT12_RS11280	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HUT12_RS11290	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HUT12_RS11295	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HUT12_RS11300	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HUT12_RS11305	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HUT12_RS11310	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HUT12_RS11315	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HUT12_RS11325	COG0165	Argininosuccinate lyase
HUT12_RS11335	COG2094	Belongs to the DNA glycosylase MPG family
HUT12_RS11345	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HUT12_RS11355	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT12_RS11365	COG0589	response to stress
HUT12_RS11385	COG1253	flavin adenine dinucleotide binding
HUT12_RS11400	COG1914	H( )-stimulated, divalent metal cation uptake system
HUT12_RS11410	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HUT12_RS11435	COG0647	UMP catabolic process
HUT12_RS11460	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HUT12_RS11465	COG0497	DNA recombination
HUT12_RS11490	COG0297	glycogen (starch) synthase activity
HUT12_RS11500	COG0504	CTP synthase activity
HUT12_RS11505	COG0494	nUDIX hydrolase
HUT12_RS11535	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HUT12_RS11540	COG1187	pseudouridine synthase activity
HUT12_RS11550	COG1160	GTP binding
HUT12_RS11570	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HUT12_RS11585	COG1309	transcriptional regulator
HUT12_RS11590	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HUT12_RS11605	COG1863	multisubunit Na H antiporter MnhE subunit
HUT12_RS11620	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HUT12_RS11620	COG2111	Na H antiporter
HUT12_RS11630	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HUT12_RS11635	COG3559	Exporter of polyketide antibiotics
HUT12_RS11640	COG1131	(ABC) transporter
HUT12_RS11645	COG1309	transcriptional regulator
HUT12_RS11655	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUT12_RS11665	COG3411	Ferredoxin
HUT12_RS11685	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HUT12_RS11690	COG0367	asparagine synthase
HUT12_RS11695	COG0174	glutamine synthetase
HUT12_RS11810	COG4585	Histidine kinase
HUT12_RS11815	COG2197	response regulator
HUT12_RS11895	COG0076	glutamate decarboxylase activity
HUT12_RS11955	COG1215	transferase activity, transferring glycosyl groups
HUT12_RS11970	COG0346	lactoylglutathione lyase activity
HUT12_RS11995	COG1595	DNA-templated transcription, initiation
HUT12_RS12030	COG1940	carbohydrate kinase activity
HUT12_RS12045	COG1595	DNA-templated transcription, initiation
HUT12_RS12055	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUT12_RS12060	COG0318	PFAM AMP-dependent synthetase and ligase
HUT12_RS12065	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HUT12_RS12120	COG1172	Belongs to the binding-protein-dependent transport system permease family
HUT12_RS12125	COG1129	ABC transporter
HUT12_RS12150	COG3971	2-oxopent-4-enoate hydratase activity
HUT12_RS12155	COG4569	acetaldehyde dehydrogenase (acetylating) activity
HUT12_RS12160	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HUT12_RS12185	COG3384	dioxygenase
HUT12_RS12210	COG0252	asparaginase activity
HUT12_RS12240	COG4691	Plasmid stability protein
HUT12_RS12245	COG1487	ribonuclease activity
HUT12_RS12270	COG1136	(ABC) transporter
HUT12_RS12270	COG0577	efflux transmembrane transporter activity
HUT12_RS12275	COG1136	(ABC) transporter
HUT12_RS12285	COG0318	PFAM AMP-dependent synthetase and ligase
HUT12_RS12295	COG2986	histidine ammonia-lyase
HUT12_RS12315	COG0475	glutathione-regulated potassium exporter activity
HUT12_RS12320	COG0745	RESPONSE REGULATOR receiver
HUT12_RS12325	COG2205	protein histidine kinase activity
HUT12_RS12335	COG3896	Chloramphenicol phosphotransferase-like protein
HUT12_RS12340	COG1733	regulation of RNA biosynthetic process
HUT12_RS12370	COG2267	carboxylic ester hydrolase activity
HUT12_RS12415	COG0667	Aldo Keto reductase
HUT12_RS12440	COG0747	negative chemotaxis
HUT12_RS12465	COG4106	trans-aconitate 2-methyltransferase activity
HUT12_RS12490	COG3976	FMN-binding domain protein
HUT12_RS12490	COG1053	succinate dehydrogenase
HUT12_RS12490	COG0431	NADPH-dependent FMN reductase
HUT12_RS12495	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUT12_RS12500	COG1335	isochorismatase
HUT12_RS12515	COG0444	Belongs to the ABC transporter superfamily
HUT12_RS12520	COG4608	Belongs to the ABC transporter superfamily
HUT12_RS12525	COG1802	Transcriptional regulator
HUT12_RS12540	COG1733	regulation of RNA biosynthetic process
HUT12_RS12565	COG2197	response regulator
HUT12_RS12570	COG0736	holo-[acyl-carrier-protein] synthase activity
HUT12_RS12575	COG1960	acyl-CoA dehydrogenase activity
HUT12_RS12605	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HUT12_RS12660	COG1366	Belongs to the anti-sigma-factor antagonist family
HUT12_RS12725	COG0477	Major facilitator Superfamily
HUT12_RS12750	COG1960	acyl-CoA dehydrogenase activity
HUT12_RS12755	COG1414	Transcriptional regulator
HUT12_RS12760	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUT12_RS12765	COG0183	Belongs to the thiolase family
HUT12_RS12800	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HUT12_RS12805	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUT12_RS12805	COG0022	dehydrogenase e1 component
HUT12_RS12815	COG0028	Belongs to the TPP enzyme family
HUT12_RS12820	COG1404	Belongs to the peptidase S8 family
HUT12_RS12840	COG1404	Belongs to the peptidase S8 family
HUT12_RS12845	COG1674	ftsk spoiiie
HUT12_RS12935	COG0714	Associated with various cellular activities
HUT12_RS12960	COG0789	Transcriptional regulator
HUT12_RS12980	COG3693	PFAM glycoside hydrolase, family 10
HUT12_RS13025	COG5002	protein histidine kinase activity
HUT12_RS13030	COG0745	RESPONSE REGULATOR receiver
HUT12_RS13040	COG1136	(ABC) transporter
HUT12_RS13040	COG0577	efflux transmembrane transporter activity
HUT12_RS13045	COG1136	(ABC) transporter
HUT12_RS13045	COG0577	efflux transmembrane transporter activity
HUT12_RS13075	COG0402	S-adenosylhomocysteine deaminase activity
HUT12_RS13105	COG1028	Short-chain dehydrogenase reductase Sdr
HUT12_RS13115	COG1309	transcriptional regulator
HUT12_RS13120	COG2409	Drug exporters of the RND superfamily
HUT12_RS13130	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUT12_RS13190	COG3507	Belongs to the glycosyl hydrolase 43 family
HUT12_RS13225	COG2226	methyltransferase
HUT12_RS13250	COG2197	response regulator
HUT12_RS13260	COG1131	(ABC) transporter
HUT12_RS13305	COG1132	(ABC) transporter
HUT12_RS13320	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HUT12_RS13325	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HUT12_RS13350	COG1834	amidinotransferase
HUT12_RS13385	COG1122	ATPase activity
HUT12_RS13395	COG0561	phosphatase activity
HUT12_RS13415	COG3119	arylsulfatase activity
HUT12_RS13420	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUT12_RS13435	COG0028	Belongs to the TPP enzyme family
HUT12_RS13475	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HUT12_RS13525	COG3903	Transcriptional regulator
HUT12_RS13525	COG3629	intracellular signal transduction
HUT12_RS13560	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HUT12_RS13565	COG4569	acetaldehyde dehydrogenase (acetylating) activity
HUT12_RS13585	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HUT12_RS13605	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
HUT12_RS13610	COG1414	Transcriptional regulator
HUT12_RS13615	COG0028	Belongs to the TPP enzyme family
HUT12_RS13620	COG1024	Enoyl-CoA hydratase
HUT12_RS13630	COG0318	PFAM AMP-dependent synthetase and ligase
HUT12_RS13655	COG2030	dehydratase
HUT12_RS13660	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HUT12_RS13665	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HUT12_RS13730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUT12_RS13740	COG0765	amino acid transport
HUT12_RS13775	COG4585	Histidine kinase
HUT12_RS13780	COG2197	response regulator
HUT12_RS13790	COG0640	Transcriptional regulator
HUT12_RS13805	COG0583	DNA-binding transcription factor activity
HUT12_RS13835	COG0778	Nitroreductase
HUT12_RS13865	COG2318	DinB family
HUT12_RS13905	COG1404	Belongs to the peptidase S8 family
HUT12_RS13915	COG3226	Transcriptional regulator
HUT12_RS13970	COG0640	Transcriptional regulator
HUT12_RS13980	COG3629	intracellular signal transduction
HUT12_RS13980	COG3903	Transcriptional regulator
HUT12_RS13985	COG3591	Belongs to the peptidase S1B family
HUT12_RS13990	COG0247	lactate metabolic process
HUT12_RS13995	COG1139	Iron-sulfur cluster binding protein
HUT12_RS14000	COG1556	Lactate utilization protein
HUT12_RS14020	COG0183	Belongs to the thiolase family
HUT12_RS14025	COG1028	Short-chain dehydrogenase reductase Sdr
HUT12_RS14035	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUT12_RS14050	COG1960	acyl-CoA dehydrogenase activity
HUT12_RS14055	COG2368	4-hydroxyphenylacetate
HUT12_RS14060	COG1960	acyl-CoA dehydrogenase activity
HUT12_RS14065	COG1024	Enoyl-CoA hydratase
HUT12_RS14075	COG0318	PFAM AMP-dependent synthetase and ligase
HUT12_RS14080	COG1024	Enoyl-CoA hydratase
HUT12_RS14085	COG1309	transcriptional regulator
HUT12_RS14090	COG0583	DNA-binding transcription factor activity
HUT12_RS14100	COG1116	anion transmembrane transporter activity
HUT12_RS14105	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUT12_RS14110	COG1960	acyl-CoA dehydrogenase activity
HUT12_RS14120	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUT12_RS14175	COG1252	NADH dehydrogenase
HUT12_RS14185	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HUT12_RS14195	COG1276	copper resistance
HUT12_RS14195	COG2372	response to copper ion
HUT12_RS14225	COG1070	Carbohydrate kinase
HUT12_RS14235	COG0395	ABC-type sugar transport system, permease component
HUT12_RS14245	COG1653	transport
HUT12_RS14260	COG1802	Transcriptional regulator
HUT12_RS14270	COG0714	Associated with various cellular activities
HUT12_RS14275	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HUT12_RS14335	COG3693	PFAM glycoside hydrolase, family 10
HUT12_RS14350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT12_RS14365	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HUT12_RS14370	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HUT12_RS14375	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HUT12_RS14390	COG1473	amidohydrolase
HUT12_RS14395	COG0673	inositol 2-dehydrogenase activity
HUT12_RS14400	COG1653	transport
HUT12_RS14405	COG1175	transmembrane transport
HUT12_RS14410	COG0395	ABC-type sugar transport system, permease component
HUT12_RS14415	COG3254	rhamnose metabolic process
HUT12_RS14420	COG4948	Mandelate Racemase Muconate Lactonizing
HUT12_RS14425	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HUT12_RS14455	COG0640	Transcriptional regulator
HUT12_RS14460	COG0346	lactoylglutathione lyase activity
HUT12_RS14475	COG0300	oxidoreductase activity
HUT12_RS14490	COG4585	Histidine kinase
HUT12_RS14495	COG2197	response regulator
HUT12_RS14510	COG3321	synthase
HUT12_RS14510	COG3321	synthase
HUT12_RS14510	COG0604	alcohol dehydrogenase
HUT12_RS14510	COG0604	alcohol dehydrogenase
HUT12_RS14525	COG0477	Major facilitator Superfamily
HUT12_RS14540	COG1309	transcriptional regulator
HUT12_RS14555	COG1228	amidohydrolase
HUT12_RS14585	COG1396	sequence-specific DNA binding
HUT12_RS14595	COG1124	(ABC) transporter
HUT12_RS14600	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUT12_RS14625	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HUT12_RS14635	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HUT12_RS14675	COG1175	transmembrane transport
HUT12_RS14680	COG0395	ABC-type sugar transport system, permease component
HUT12_RS14685	COG4948	Mandelate Racemase Muconate Lactonizing
HUT12_RS14695	COG1129	ABC transporter
HUT12_RS14700	COG1172	Belongs to the binding-protein-dependent transport system permease family
HUT12_RS14705	COG1172	Belongs to the binding-protein-dependent transport system permease family
HUT12_RS14710	COG4213	ABC transporter substrate-binding protein
HUT12_RS14750	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUT12_RS14765	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HUT12_RS14790	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HUT12_RS14800	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT12_RS14810	COG1920	GTP binding
HUT12_RS14835	COG2186	Transcriptional regulator
HUT12_RS14860	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUT12_RS14870	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HUT12_RS14895	COG1228	amidohydrolase
HUT12_RS14920	COG3629	intracellular signal transduction
HUT12_RS14920	COG3903	Transcriptional regulator
HUT12_RS14930	COG3842	ATPase activity
HUT12_RS14935	COG1176	ABC-type spermidine putrescine transport system, permease component I
HUT12_RS14940	COG1012	belongs to the aldehyde dehydrogenase family
HUT12_RS14955	COG1609	Transcriptional regulator
HUT12_RS14965	COG1012	belongs to the aldehyde dehydrogenase family
HUT12_RS14970	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HUT12_RS14975	COG1028	Short-chain dehydrogenase reductase Sdr
HUT12_RS14980	COG1735	metal-dependent hydrolase with the TIM-barrel fold
HUT12_RS14985	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HUT12_RS14995	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HUT12_RS15005	COG0402	S-adenosylhomocysteine deaminase activity
HUT12_RS15010	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HUT12_RS15030	COG1175	transmembrane transport
HUT12_RS15040	COG1070	Carbohydrate kinase
HUT12_RS15045	COG1063	alcohol dehydrogenase
HUT12_RS15050	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HUT12_RS15090	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUT12_RS15125	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HUT12_RS15130	COG0583	DNA-binding transcription factor activity
HUT12_RS15135	COG0596	Alpha beta hydrolase
HUT12_RS15150	COG4585	Histidine kinase
HUT12_RS15155	COG2197	response regulator
HUT12_RS15165	COG0443	Heat shock 70 kDa protein
HUT12_RS15190	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUT12_RS15220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT12_RS15225	COG1064	alcohol dehydrogenase
HUT12_RS15230	COG2133	pyrroloquinoline quinone binding
HUT12_RS15240	COG0583	DNA-binding transcription factor activity
HUT12_RS15285	COG2022	thiamine diphosphate biosynthetic process
HUT12_RS15285	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HUT12_RS15295	COG3938	Belongs to the proline racemase family
HUT12_RS15300	COG1012	belongs to the aldehyde dehydrogenase family
HUT12_RS15305	COG1802	Transcriptional regulator
HUT12_RS15310	COG1132	(ABC) transporter
HUT12_RS15315	COG1132	(ABC) transporter
HUT12_RS15325	COG0165	Argininosuccinate lyase
HUT12_RS15345	COG3842	ATPase activity
HUT12_RS15350	COG1840	ABC-type Fe3 transport system, periplasmic component
HUT12_RS15355	COG1940	carbohydrate kinase activity
HUT12_RS15360	COG0583	DNA-binding transcription factor activity
HUT12_RS15365	COG0667	Aldo Keto reductase
HUT12_RS15395	COG0601	transmembrane transport
HUT12_RS15405	COG0444	Belongs to the ABC transporter superfamily
HUT12_RS15410	COG4608	Belongs to the ABC transporter superfamily
HUT12_RS15415	COG1959	2 iron, 2 sulfur cluster binding
HUT12_RS15430	COG4208	sulfate ABC transporter
HUT12_RS15435	COG3842	ATPase activity
HUT12_RS15445	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUT12_RS15455	COG1116	anion transmembrane transporter activity
HUT12_RS15485	COG1609	Transcriptional regulator
HUT12_RS15495	COG1175	transmembrane transport
HUT12_RS15500	COG0395	ABC-type sugar transport system, permease component
HUT12_RS15530	COG4214	carbohydrate transport
HUT12_RS15540	COG3345	alpha-galactosidase
HUT12_RS15555	COG1879	ABC-type sugar transport system periplasmic component
HUT12_RS15565	COG1172	Belongs to the binding-protein-dependent transport system permease family
HUT12_RS15570	COG1172	Belongs to the binding-protein-dependent transport system permease family
HUT12_RS15575	COG2160	L-arabinose isomerase activity
HUT12_RS15580	COG2267	carboxylic ester hydrolase activity
HUT12_RS15590	COG3507	Belongs to the glycosyl hydrolase 43 family
HUT12_RS15605	COG3509	depolymerase
HUT12_RS15615	COG1129	ABC transporter
HUT12_RS15620	COG1172	Belongs to the binding-protein-dependent transport system permease family
HUT12_RS15625	COG4948	Mandelate Racemase Muconate Lactonizing
HUT12_RS15640	COG1063	alcohol dehydrogenase
HUT12_RS15645	COG1028	Short-chain dehydrogenase reductase Sdr
HUT12_RS15710	COG3021	interspecies interaction between organisms
HUT12_RS15725	COG1131	(ABC) transporter
HUT12_RS15735	COG1309	transcriptional regulator
HUT12_RS15760	COG4221	oxidoreductase activity
HUT12_RS15840	COG3655	Transcriptional regulator
HUT12_RS15850	COG1609	Transcriptional regulator
HUT12_RS15855	COG1609	Transcriptional regulator
HUT12_RS15865	COG1175	transmembrane transport
HUT12_RS15870	COG0395	ABC-type sugar transport system, permease component
HUT12_RS15900	COG3509	depolymerase
HUT12_RS15925	COG2205	protein histidine kinase activity
HUT12_RS15930	COG0745	RESPONSE REGULATOR receiver
HUT12_RS15935	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUT12_RS15940	COG2304	oxidoreductase activity
HUT12_RS15950	COG0714	Associated with various cellular activities
HUT12_RS15965	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HUT12_RS15970	COG4326	sporulation control protein
HUT12_RS16035	COG3507	Belongs to the glycosyl hydrolase 43 family
HUT12_RS16060	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUT12_RS16065	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUT12_RS16095	COG2197	response regulator
HUT12_RS16100	COG4585	Histidine kinase
HUT12_RS16135	COG0640	Transcriptional regulator
HUT12_RS16155	COG0318	PFAM AMP-dependent synthetase and ligase
HUT12_RS16170	COG0604	alcohol dehydrogenase
HUT12_RS16200	COG3507	Belongs to the glycosyl hydrolase 43 family
HUT12_RS16220	COG1414	Transcriptional regulator
HUT12_RS16225	COG0800	Aldolase
HUT12_RS16230	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUT12_RS16235	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HUT12_RS16275	COG5398	heme oxygenase
HUT12_RS16285	COG1120	ATPase activity
HUT12_RS16290	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUT12_RS16295	COG4558	Periplasmic binding protein
HUT12_RS16375	COG2814	Major facilitator Superfamily
HUT12_RS16420	COG0395	ABC-type sugar transport system, permease component
HUT12_RS16425	COG1063	alcohol dehydrogenase
HUT12_RS16435	COG4260	virion core protein, lumpy skin disease virus
HUT12_RS16460	COG0604	alcohol dehydrogenase
HUT12_RS16485	COG3608	succinylglutamate desuccinylase aspartoacylase
HUT12_RS16485	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HUT12_RS16515	COG1028	Short-chain dehydrogenase reductase Sdr
HUT12_RS16530	COG2207	Transcriptional regulator
HUT12_RS16545	COG0179	Fumarylacetoacetate (FAA) hydrolase
HUT12_RS16570	COG0439	Biotin carboxylase
HUT12_RS16585	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HUT12_RS16605	COG2197	response regulator
HUT12_RS16640	COG1104	cysteine desulfurase activity
HUT12_RS16645	COG4106	trans-aconitate 2-methyltransferase activity
HUT12_RS16650	COG2353	YceI-like domain
HUT12_RS16735	COG5002	protein histidine kinase activity
HUT12_RS16735	COG3447	MASE1 domain protein
HUT12_RS16735	COG5001	Diguanylate cyclase
HUT12_RS16750	COG5006	permease, DMT superfamily
HUT12_RS16755	COG0531	amino acid
HUT12_RS16760	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HUT12_RS16785	COG0018	arginyl-trna synthetase
HUT12_RS16800	COG0475	glutathione-regulated potassium exporter activity
HUT12_RS16825	COG0488	(ABC) transporter
HUT12_RS16835	COG0697	spore germination
HUT12_RS16840	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HUT12_RS16850	COG3629	intracellular signal transduction
HUT12_RS16850	COG3903	Transcriptional regulator
HUT12_RS16900	COG2318	DinB family
HUT12_RS16910	COG2197	response regulator
HUT12_RS16915	COG4585	Histidine kinase
HUT12_RS16925	COG0387	Pfam Sodium calcium exchanger
HUT12_RS16935	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUT12_RS16940	COG0577	efflux transmembrane transporter activity
HUT12_RS16940	COG1136	(ABC) transporter
HUT12_RS16945	COG1136	(ABC) transporter
HUT12_RS16945	COG0577	efflux transmembrane transporter activity
HUT12_RS16950	COG2197	response regulator
HUT12_RS16955	COG4585	Histidine kinase
HUT12_RS16965	COG0517	IMP dehydrogenase activity
HUT12_RS16965	COG1994	Peptidase M50
HUT12_RS16985	COG1222	aaa ATPase
HUT12_RS16995	COG4122	O-methyltransferase activity
HUT12_RS17010	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HUT12_RS17015	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HUT12_RS17060	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HUT12_RS17080	COG2378	regulation of single-species biofilm formation
HUT12_RS17090	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HUT12_RS17110	COG3507	Belongs to the glycosyl hydrolase 43 family
HUT12_RS17115	COG3507	Belongs to the glycosyl hydrolase 43 family
HUT12_RS17135	COG1960	acyl-CoA dehydrogenase activity
HUT12_RS17195	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUT12_RS17265	COG2186	Transcriptional regulator
HUT12_RS17290	COG1960	acyl-CoA dehydrogenase activity
HUT12_RS17315	COG2378	regulation of single-species biofilm formation
HUT12_RS17320	COG0596	Alpha beta hydrolase
HUT12_RS17330	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HUT12_RS17335	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HUT12_RS17340	COG3485	protocatechuate 3,4-dioxygenase
HUT12_RS17345	COG3485	protocatechuate 3,4-dioxygenase
HUT12_RS17355	COG0596	Alpha beta hydrolase
HUT12_RS17360	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HUT12_RS17365	COG1414	Transcriptional regulator
HUT12_RS17430	COG0573	inorganic phosphate transmembrane transporter activity
HUT12_RS17435	COG0581	inorganic phosphate transmembrane transporter activity
HUT12_RS17440	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HUT12_RS17445	COG0745	RESPONSE REGULATOR receiver
HUT12_RS17470	COG2199	diguanylate cyclase activity
HUT12_RS17485	COG1609	Transcriptional regulator
HUT12_RS17495	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HUT12_RS17495	COG0515	serine threonine protein kinase
HUT12_RS17515	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HUT12_RS17535	COG1686	Belongs to the peptidase S11 family
HUT12_RS17540	COG1686	Belongs to the peptidase S11 family
HUT12_RS17545	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HUT12_RS17565	COG2111	Na H antiporter
HUT12_RS17565	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HUT12_RS17585	COG2212	antiporter activity
HUT12_RS17595	COG1690	Belongs to the RtcB family
HUT12_RS17615	COG3629	intracellular signal transduction
HUT12_RS17615	COG3903	Transcriptional regulator
HUT12_RS17625	COG1216	Glycosyl transferase, family 2
HUT12_RS17630	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HUT12_RS17635	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUT12_RS17640	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HUT12_RS17645	COG1215	transferase activity, transferring glycosyl groups
HUT12_RS17650	COG1216	Glycosyl transferase, family 2
HUT12_RS17680	COG1131	(ABC) transporter
HUT12_RS17685	COG4585	Histidine kinase
HUT12_RS17690	COG2197	response regulator
HUT12_RS17725	COG0438	transferase activity, transferring glycosyl groups
HUT12_RS17740	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HUT12_RS17745	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HUT12_RS17770	COG3486	L-lysine 6-monooxygenase (NADPH) activity
HUT12_RS17805	COG1609	Transcriptional regulator
HUT12_RS17810	COG0673	inositol 2-dehydrogenase activity
HUT12_RS17830	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HUT12_RS17840	COG1960	acyl-CoA dehydrogenase activity
HUT12_RS17850	COG0406	alpha-ribazole phosphatase activity
HUT12_RS17855	COG0488	(ABC) transporter
HUT12_RS17865	COG1509	lysine 2,3-aminomutase activity
HUT12_RS17870	COG0604	alcohol dehydrogenase
HUT12_RS17875	COG1228	amidohydrolase
HUT12_RS17880	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HUT12_RS17885	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUT12_RS17890	COG1607	acyl-coa hydrolase
HUT12_RS17915	COG1216	Glycosyl transferase, family 2
HUT12_RS17940	COG1609	Transcriptional regulator
HUT12_RS17945	COG1472	Belongs to the glycosyl hydrolase 3 family
HUT12_RS17950	COG1940	carbohydrate kinase activity
HUT12_RS17960	COG4209	transmembrane transport
HUT12_RS17965	COG0395	ABC-type sugar transport system, permease component
HUT12_RS17970	COG1501	Belongs to the glycosyl hydrolase 31 family
HUT12_RS17980	COG0477	Major facilitator Superfamily
HUT12_RS17985	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HUT12_RS17995	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUT12_RS18010	COG0071	Belongs to the small heat shock protein (HSP20) family
HUT12_RS18015	COG4974	Belongs to the 'phage' integrase family
HUT12_RS18025	COG1136	(ABC) transporter
HUT12_RS18025	COG4591	ABC-type transport system involved in lipoprotein release permease component
HUT12_RS18030	COG0577	efflux transmembrane transporter activity
HUT12_RS18030	COG1136	(ABC) transporter
HUT12_RS18045	COG1435	thymidine kinase activity
HUT12_RS18050	COG2270	Major facilitator Superfamily
HUT12_RS18075	COG0204	Acyl-transferase
HUT12_RS18080	COG1271	oxidase subunit
HUT12_RS18085	COG1294	oxidase, subunit
HUT12_RS18105	COG1028	Short-chain dehydrogenase reductase Sdr
HUT12_RS18115	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUT12_RS18125	COG1335	isochorismatase
HUT12_RS18135	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUT12_RS18150	COG1012	belongs to the aldehyde dehydrogenase family
HUT12_RS18160	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUT12_RS18175	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HUT12_RS18210	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HUT12_RS18235	COG0242	peptide deformylase activity
HUT12_RS18250	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HUT12_RS18250	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HUT12_RS18255	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HUT12_RS18265	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HUT12_RS18265	COG1017	nitric oxide dioxygenase activity
HUT12_RS18385	COG0437	4 iron, 4 sulfur cluster binding
HUT12_RS18410	COG1028	Short-chain dehydrogenase reductase Sdr
HUT12_RS18415	COG0644	oxidoreductase
HUT12_RS18445	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUT12_RS18485	COG1653	transport
HUT12_RS18490	COG1175	transmembrane transport
HUT12_RS18515	COG1357	PFAM Pentapeptide repeats (8 copies)
HUT12_RS18520	COG0328	RNA-DNA hybrid ribonuclease activity
HUT12_RS18560	COG3012	SEC-C Motif Domain Protein
HUT12_RS18590	COG0069	glutamate synthase activity
HUT12_RS18615	COG2197	response regulator
HUT12_RS18635	COG3265	gluconokinase activity
HUT12_RS18640	COG4948	Mandelate Racemase Muconate Lactonizing
HUT12_RS18650	COG0800	Aldolase
HUT12_RS18655	COG4948	Mandelate Racemase Muconate Lactonizing
HUT12_RS18660	COG0395	ABC-type sugar transport system, permease component
HUT12_RS18665	COG1175	transmembrane transport
HUT12_RS18695	COG1595	DNA-templated transcription, initiation
HUT12_RS18700	COG1090	epimerase
HUT12_RS18745	COG2197	response regulator
HUT12_RS18795	COG0697	spore germination
HUT12_RS18800	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUT12_RS18805	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HUT12_RS18850	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HUT12_RS18855	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HUT12_RS18860	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HUT12_RS18905	COG2226	methyltransferase
HUT12_RS18920	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HUT12_RS18955	COG1803	Methylglyoxal synthase
HUT12_RS18955	COG1597	lipid kinase activity
HUT12_RS18960	COG0789	Transcriptional regulator
HUT12_RS18965	COG0326	Molecular chaperone. Has ATPase activity
HUT12_RS18980	COG2205	protein histidine kinase activity
HUT12_RS18985	COG0745	RESPONSE REGULATOR receiver
HUT12_RS19000	COG1366	Belongs to the anti-sigma-factor antagonist family
HUT12_RS19045	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HUT12_RS19060	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUT12_RS19065	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HUT12_RS19080	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUT12_RS19085	COG0183	Belongs to the thiolase family
HUT12_RS19095	COG1021	2,3-dihydroxybenzoate-AMP ligase
HUT12_RS19100	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HUT12_RS19110	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUT12_RS19130	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HUT12_RS19145	COG1960	acyl-CoA dehydrogenase activity
HUT12_RS19150	COG1960	acyl-CoA dehydrogenase activity
HUT12_RS19180	COG2226	methyltransferase
HUT12_RS19180	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUT12_RS19180	COG3433	isochorismatase activity
HUT12_RS19185	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUT12_RS19185	COG3433	isochorismatase activity
HUT12_RS19185	COG2226	methyltransferase
HUT12_RS19190	COG2091	lysine biosynthetic process via aminoadipic acid
HUT12_RS19195	COG0477	Major facilitator Superfamily
HUT12_RS19210	COG2124	cytochrome p450
HUT12_RS19225	COG2124	cytochrome p450
HUT12_RS19245	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT12_RS19280	COG1012	belongs to the aldehyde dehydrogenase family
HUT12_RS19310	COG1116	anion transmembrane transporter activity
HUT12_RS19335	COG0683	leucine binding
HUT12_RS19350	COG0829	nickel cation binding
HUT12_RS19355	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HUT12_RS19370	COG0832	Belongs to the urease beta subunit family
HUT12_RS19380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUT12_RS19385	COG0765	amino acid transport
HUT12_RS19390	COG1126	abc transporter atp-binding protein
HUT12_RS19425	COG3559	Exporter of polyketide antibiotics
HUT12_RS19430	COG1131	(ABC) transporter
HUT12_RS19435	COG1309	transcriptional regulator
HUT12_RS19445	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HUT12_RS19450	COG0300	oxidoreductase activity
HUT12_RS19455	COG0596	Alpha beta hydrolase
HUT12_RS19455	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUT12_RS19490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT12_RS19495	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HUT12_RS19500	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUT12_RS19505	COG1116	anion transmembrane transporter activity
HUT12_RS19510	COG2855	membrane
HUT12_RS19525	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HUT12_RS19550	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUT12_RS19565	COG3458	cephalosporin-C deacetylase activity
HUT12_RS19575	COG1472	Belongs to the glycosyl hydrolase 3 family
HUT12_RS19580	COG4209	transmembrane transport
HUT12_RS19585	COG0395	ABC-type sugar transport system, permease component
HUT12_RS19590	COG1653	transport
HUT12_RS19615	COG1122	ATPase activity
HUT12_RS19625	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
HUT12_RS19630	COG0310	cobalt ion transport
HUT12_RS19690	COG0076	glutamate decarboxylase activity
HUT12_RS19705	COG4221	oxidoreductase activity
HUT12_RS19710	COG2723	6-phospho-beta-galactosidase activity
HUT12_RS19715	COG0395	ABC-type sugar transport system, permease component
HUT12_RS19720	COG1175	transmembrane transport
HUT12_RS19740	COG0583	DNA-binding transcription factor activity
HUT12_RS19745	COG1028	Short-chain dehydrogenase reductase Sdr
HUT12_RS19750	COG1309	transcriptional regulator
HUT12_RS19760	COG1410	methionine synthase
HUT12_RS19760	COG0646	methionine synthase
HUT12_RS19775	COG0215	cysteine-tRNA ligase activity
HUT12_RS19805	COG1968	undecaprenyl-diphosphatase activity
HUT12_RS19810	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT12_RS19815	COG0667	Aldo Keto reductase
HUT12_RS19830	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUT12_RS19860	COG0542	response to heat
HUT12_RS19880	COG1674	ftsk spoiiie
HUT12_RS19900	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HUT12_RS19910	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HUT12_RS19920	COG0745	RESPONSE REGULATOR receiver
HUT12_RS19925	COG0745	RESPONSE REGULATOR receiver
HUT12_RS19960	COG0653	protein targeting
HUT12_RS19965	COG0463	Glycosyl transferase, family 2
HUT12_RS19975	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HUT12_RS19980	COG1191	sigma factor activity
HUT12_RS20005	COG2409	Drug exporters of the RND superfamily
HUT12_RS20030	COG0137	argininosuccinate synthase activity
HUT12_RS20035	COG0583	DNA-binding transcription factor activity
HUT12_RS20050	COG3293	Transposase
HUT12_RS20055	COG3293	Transposase
HUT12_RS20125	COG2205	protein histidine kinase activity
HUT12_RS20130	COG0745	RESPONSE REGULATOR receiver
HUT12_RS20140	COG2815	serine threonine protein kinase
HUT12_RS20140	COG0515	serine threonine protein kinase
HUT12_RS20155	COG0784	Response regulator, receiver
HUT12_RS20160	COG1366	Belongs to the anti-sigma-factor antagonist family
HUT12_RS20175	COG1366	Belongs to the anti-sigma-factor antagonist family
HUT12_RS20195	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUT12_RS20205	COG0633	Ferredoxin
HUT12_RS20205	COG0543	2 iron, 2 sulfur cluster binding
HUT12_RS20210	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HUT12_RS20225	COG2239	Acts as a magnesium transporter
HUT12_RS20235	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUT12_RS20265	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HUT12_RS20275	COG0789	Transcriptional regulator
HUT12_RS20310	COG0489	protein tyrosine kinase activity
HUT12_RS20325	COG2119	membrane
HUT12_RS20330	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HUT12_RS20335	COG0121	glutamine amidotransferase
HUT12_RS20340	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HUT12_RS20360	COG0515	serine threonine protein kinase
HUT12_RS20380	COG2197	response regulator
HUT12_RS20410	COG0367	asparagine synthase
HUT12_RS20435	COG2197	response regulator
HUT12_RS20440	COG4585	Histidine kinase
HUT12_RS20455	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HUT12_RS20475	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HUT12_RS20495	COG1376	ErfK ybiS ycfS ynhG family protein
HUT12_RS20525	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HUT12_RS20575	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HUT12_RS20590	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HUT12_RS20595	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HUT12_RS20610	COG0439	Biotin carboxylase
HUT12_RS20615	COG0511	ligase activity, forming carbon-carbon bonds
HUT12_RS20620	COG0825	malonyl-CoA metabolic process
HUT12_RS20620	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HUT12_RS20630	COG3903	Transcriptional regulator
HUT12_RS20630	COG3629	intracellular signal transduction
HUT12_RS20640	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUT12_RS20675	COG2197	response regulator
HUT12_RS20695	COG2226	methyltransferase
HUT12_RS20705	COG0738	Major facilitator superfamily
HUT12_RS20800	COG0706	membrane insertase activity
HUT12_RS20805	COG1472	Belongs to the glycosyl hydrolase 3 family
HUT12_RS20810	COG0395	ABC-type sugar transport system, permease component
HUT12_RS20815	COG1175	transmembrane transport
HUT12_RS20825	COG1609	Transcriptional regulator
HUT12_RS20865	COG0395	ABC-type sugar transport system, permease component
HUT12_RS20870	COG1175	transmembrane transport
HUT12_RS20885	COG0673	inositol 2-dehydrogenase activity
HUT12_RS20890	COG1904	glucuronate isomerase
HUT12_RS20895	COG4948	Mandelate Racemase Muconate Lactonizing
HUT12_RS20900	COG0246	Mannitol dehydrogenase
HUT12_RS20905	COG0673	inositol 2-dehydrogenase activity
HUT12_RS20910	COG3866	Pectate lyase
HUT12_RS20930	COG2200	EAL domain
HUT12_RS20955	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HUT12_RS20960	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HUT12_RS20975	COG2132	Multicopper oxidase
HUT12_RS21010	COG0667	Aldo Keto reductase
HUT12_RS21035	COG4585	Histidine kinase
HUT12_RS21090	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HUT12_RS21115	COG1704	LemA family
HUT12_RS21140	COG0477	Major facilitator Superfamily
HUT12_RS21150	COG1136	(ABC) transporter
HUT12_RS21170	COG0009	L-threonylcarbamoyladenylate synthase
HUT12_RS21200	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HUT12_RS21205	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUT12_RS21215	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HUT12_RS21220	COG2226	methyltransferase
HUT12_RS21225	COG1609	Transcriptional regulator
HUT12_RS21240	COG1175	transmembrane transport
HUT12_RS21245	COG0395	ABC-type sugar transport system, permease component
HUT12_RS21255	COG1316	TRANSCRIPTIONal
HUT12_RS21270	COG0438	transferase activity, transferring glycosyl groups
HUT12_RS21335	COG0714	Associated with various cellular activities
HUT12_RS21350	COG1028	Short-chain dehydrogenase reductase Sdr
HUT12_RS21390	COG5297	Belongs to the glycosyl hydrolase family 6
HUT12_RS21390	COG4733	cellulase activity
HUT12_RS21395	COG2723	6-phospho-beta-galactosidase activity
HUT12_RS21405	COG2018	Roadblock/LC7 domain
HUT12_RS21425	COG0655	NAD(P)H dehydrogenase (quinone) activity
HUT12_RS21440	COG4585	Histidine kinase
HUT12_RS21450	COG0456	acetyltransferase
HUT12_RS21455	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUT12_RS21475	COG0662	Cupin 2, conserved barrel domain protein
HUT12_RS21485	COG0640	Transcriptional regulator
HUT12_RS21495	COG1595	DNA-templated transcription, initiation
HUT12_RS21500	COG2249	NAD(P)H dehydrogenase (quinone) activity
HUT12_RS21530	COG0300	oxidoreductase activity
HUT12_RS21560	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HUT12_RS21600	COG0745	RESPONSE REGULATOR receiver
HUT12_RS21625	COG1695	Transcriptional regulator
HUT12_RS21635	COG2318	DinB family
HUT12_RS21640	COG2197	response regulator
HUT12_RS21650	COG3629	intracellular signal transduction
HUT12_RS21650	COG3903	Transcriptional regulator
HUT12_RS21725	COG0574	Belongs to the PEP-utilizing enzyme family
HUT12_RS21725	COG3848	Pyruvate phosphate dikinase
HUT12_RS21730	COG0789	Transcriptional regulator
HUT12_RS21735	COG1309	transcriptional regulator
HUT12_RS21755	COG2813	Specifically methylates the guanine in position
HUT12_RS21760	COG2318	DinB family
HUT12_RS21840	COG1131	(ABC) transporter
HUT12_RS21850	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUT12_RS21855	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUT12_RS21860	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUT12_RS21860	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUT12_RS21860	COG3321	synthase
HUT12_RS21860	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUT12_RS21860	COG1028	Short-chain dehydrogenase reductase Sdr
HUT12_RS21865	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUT12_RS21865	COG0300	oxidoreductase activity
HUT12_RS21865	COG3321	synthase
HUT12_RS21865	COG4221	oxidoreductase activity
HUT12_RS21880	COG1960	acyl-CoA dehydrogenase activity
HUT12_RS21895	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUT12_RS21900	COG2264	protein methyltransferase activity
HUT12_RS21960	COG2815	serine threonine protein kinase
HUT12_RS21960	COG0515	serine threonine protein kinase
HUT12_RS21975	COG1988	membrane-bound metal-dependent
HUT12_RS21990	COG1175	transmembrane transport
HUT12_RS21995	COG0395	ABC-type sugar transport system, permease component
HUT12_RS22000	COG1501	Belongs to the glycosyl hydrolase 31 family
HUT12_RS22025	COG2080	2 iron, 2 sulfur cluster binding
HUT12_RS22030	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HUT12_RS22035	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HUT12_RS22040	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HUT12_RS22055	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HUT12_RS22055	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HUT12_RS22060	COG0346	lactoylglutathione lyase activity
HUT12_RS22065	COG0395	ABC-type sugar transport system, permease component
HUT12_RS22070	COG1175	transmembrane transport
HUT12_RS22080	COG4821	SIS domain
HUT12_RS22085	COG1737	Transcriptional regulator
HUT12_RS22095	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HUT12_RS22110	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HUT12_RS22125	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HUT12_RS22130	COG1365	unkown
HUT12_RS22150	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
HUT12_RS22155	COG0583	DNA-binding transcription factor activity
HUT12_RS22180	COG3214	Protein conserved in bacteria
HUT12_RS22190	COG1028	Short-chain dehydrogenase reductase Sdr
HUT12_RS22195	COG4608	Belongs to the ABC transporter superfamily
HUT12_RS22200	COG0444	Belongs to the ABC transporter superfamily
HUT12_RS22205	COG0747	negative chemotaxis
HUT12_RS22220	COG1012	belongs to the aldehyde dehydrogenase family
HUT12_RS22225	COG0673	inositol 2-dehydrogenase activity
HUT12_RS22230	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HUT12_RS22250	COG1414	Transcriptional regulator
HUT12_RS22255	COG0028	Belongs to the TPP enzyme family
HUT12_RS22305	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HUT12_RS22330	COG0714	Associated with various cellular activities
HUT12_RS22365	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUT12_RS22380	COG0006	proline dipeptidase activity
HUT12_RS22440	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HUT12_RS22455	COG2018	Roadblock/LC7 domain
HUT12_RS22495	COG1309	transcriptional regulator
HUT12_RS22505	COG3220	belongs to the UPF0276 family
HUT12_RS22515	COG1028	Short-chain dehydrogenase reductase Sdr
HUT12_RS22525	COG1132	(ABC) transporter
HUT12_RS22530	COG1024	Enoyl-CoA hydratase
HUT12_RS22545	COG0488	(ABC) transporter
HUT12_RS22550	COG2321	neutral zinc metallopeptidase
HUT12_RS22560	COG1072	(Pantothenic acid kinase))
HUT12_RS22575	COG1172	Belongs to the binding-protein-dependent transport system permease family
HUT12_RS22590	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HUT12_RS22600	COG0246	Mannitol dehydrogenase
HUT12_RS22605	COG2897	thiosulfate sulfurtransferase activity
HUT12_RS22630	COG0822	iron-sulfur transferase activity
HUT12_RS22635	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HUT12_RS22640	COG0396	ATPase activity
HUT12_RS22645	COG2146	nitrite reductase [NAD(P)H] activity
HUT12_RS22680	COG0109	protoheme IX farnesyltransferase activity
HUT12_RS22690	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HUT12_RS22695	COG0166	Belongs to the GPI family
HUT12_RS22710	COG0363	glucosamine-6-phosphate deaminase activity
HUT12_RS22720	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HUT12_RS22725	COG0149	triose-phosphate isomerase activity
HUT12_RS22730	COG0126	phosphoglycerate kinase activity
HUT12_RS22735	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HUT12_RS22740	COG1481	regulation of sporulation
HUT12_RS22750	COG1660	Displays ATPase and GTPase activities
HUT12_RS22765	COG0322	excinuclease ABC activity
HUT12_RS22785	COG1162	GTPase activity
HUT12_RS22795	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUT12_RS22825	COG0270	DNA (cytosine-5-)-methyltransferase activity
HUT12_RS22895	COG5377	YqaJ viral recombinase family
HUT12_RS22980	COG0592	DNA-directed DNA polymerase activity
HUT12_RS23025	COG0305	Participates in initiation and elongation during chromosome replication
HUT12_RS23125	COG1783	phage Terminase large subunit
HUT12_RS23310	COG0494	nUDIX hydrolase
HUT12_RS23565	COG3293	Transposase
HUT12_RS23570	COG3293	Transposase
HUT12_RS23745	COG1278	Cold shock
HUT12_RS23760	COG1846	Transcriptional regulator
HUT12_RS23765	COG2409	Drug exporters of the RND superfamily
HUT12_RS23790	COG2365	Tyrosine phosphatase family
HUT12_RS23805	COG2329	Antibiotic biosynthesis monooxygenase
HUT12_RS23825	COG0237	dephospho-CoA kinase activity
HUT12_RS23825	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HUT12_RS23830	COG0539	negative regulation of cytoplasmic translation
HUT12_RS23835	COG2226	methyltransferase
HUT12_RS23850	COG0789	Transcriptional regulator
HUT12_RS23905	COG0626	cystathionine gamma-synthase activity
HUT12_RS23915	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT12_RS23920	COG3401	FG-GAP repeat protein
HUT12_RS23930	COG0730	response to heat
HUT12_RS23940	COG1946	Acyl-CoA thioesterase
HUT12_RS23955	COG0667	Aldo Keto reductase
HUT12_RS23965	COG1253	flavin adenine dinucleotide binding
HUT12_RS24000	COG3293	Transposase
HUT12_RS24005	COG3293	Transposase
HUT12_RS24030	COG0069	glutamate synthase activity
HUT12_RS24030	COG0070	glutamate synthase
HUT12_RS24030	COG0067	glutamate synthase
HUT12_RS24045	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HUT12_RS24050	COG0159	tryptophan synthase activity
HUT12_RS24055	COG0133	tryptophan synthase activity
HUT12_RS24060	COG0134	indole-3-glycerol-phosphate synthase activity
HUT12_RS24080	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HUT12_RS24105	COG1132	(ABC) transporter
HUT12_RS24110	COG1132	(ABC) transporter
HUT12_RS24120	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUT12_RS24125	COG1022	Amp-dependent synthetase and ligase
HUT12_RS24135	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUT12_RS24150	COG0107	imidazoleglycerol-phosphate synthase activity
HUT12_RS24155	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HUT12_RS24165	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HUT12_RS24175	COG0131	Imidazoleglycerol-phosphate dehydratase
HUT12_RS24180	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HUT12_RS24185	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HUT12_RS24190	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HUT12_RS24215	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HUT12_RS24245	COG1799	cell septum assembly
HUT12_RS24255	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HUT12_RS24265	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HUT12_RS24270	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HUT12_RS24280	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HUT12_RS24290	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HUT12_RS24295	COG0768	penicillin binding
HUT12_RS24305	COG0275	rRNA processing
HUT12_RS24310	COG2001	Belongs to the MraZ family
HUT12_RS24320	COG3442	glutamine amidotransferase
HUT12_RS24330	COG0495	leucyl-tRNA aminoacylation
HUT12_RS24355	COG1006	Multisubunit Na H antiporter MnhC subunit
HUT12_RS24360	COG2111	Na H antiporter
HUT12_RS24360	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HUT12_RS24365	COG0714	Associated with various cellular activities
HUT12_RS24385	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HUT12_RS24400	COG0587	DNA-directed DNA polymerase activity
HUT12_RS24470	COG2815	serine threonine protein kinase
HUT12_RS24470	COG0515	serine threonine protein kinase
HUT12_RS24475	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HUT12_RS24485	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HUT12_RS24510	COG4175	Glycine betaine
HUT12_RS24510	COG0517	IMP dehydrogenase activity
HUT12_RS24515	COG4176	ABC-type proline glycine betaine transport system permease component
HUT12_RS24520	COG2113	Glycine betaine
HUT12_RS24525	COG0386	Belongs to the glutathione peroxidase family
HUT12_RS24555	COG0205	6-phosphofructokinase activity
HUT12_RS24595	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HUT12_RS24605	COG2072	flavoprotein involved in K transport
HUT12_RS24615	COG1940	carbohydrate kinase activity
HUT12_RS24640	COG2197	response regulator
HUT12_RS24655	COG0438	transferase activity, transferring glycosyl groups
HUT12_RS24660	COG0501	Belongs to the peptidase M48B family
HUT12_RS24675	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HUT12_RS24685	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HUT12_RS24700	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HUT12_RS24710	COG2010	Cytochrome c
HUT12_RS24730	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HUT12_RS24745	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HUT12_RS24775	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUT12_RS24790	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HUT12_RS24795	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HUT12_RS24810	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HUT12_RS24815	COG1396	sequence-specific DNA binding
HUT12_RS24825	COG0667	Aldo Keto reductase
HUT12_RS24830	COG1994	Peptidase M50
HUT12_RS24845	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HUT12_RS24850	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HUT12_RS24860	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HUT12_RS24865	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HUT12_RS24875	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HUT12_RS24880	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUT12_RS24920	COG0321	lipoyl(octanoyl) transferase activity
HUT12_RS24940	COG0017	Asparaginyl-tRNA synthetase
HUT12_RS24945	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HUT12_RS24985	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HUT12_RS25015	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HUT12_RS25025	COG0174	glutamine synthetase
HUT12_RS25045	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HUT12_RS25050	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HUT12_RS25050	COG0519	Catalyzes the synthesis of GMP from XMP
HUT12_RS25055	COG1619	proteins homologs of microcin C7 resistance protein MccF
HUT12_RS25065	COG3766	membrane
HUT12_RS25070	COG0174	glutamine synthetase
HUT12_RS25075	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HUT12_RS25075	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HUT12_RS25080	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HUT12_RS25095	COG0557	exoribonuclease II activity
HUT12_RS25125	COG2207	Transcriptional regulator
HUT12_RS25125	COG3708	Transcriptional regulator
HUT12_RS25140	COG2188	Transcriptional regulator
HUT12_RS25215	COG2188	Transcriptional regulator
HUT12_RS25235	COG1192	Involved in chromosome partitioning
HUT12_RS25250	COG2318	DinB family
HUT12_RS25265	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HUT12_RS25295	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HUT12_RS25315	COG4279	zinc finger
HUT12_RS25320	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HUT12_RS25330	COG2318	DinB family
HUT12_RS25350	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HUT12_RS25355	COG2267	carboxylic ester hydrolase activity
HUT12_RS25375	COG0022	dehydrogenase e1 component
HUT12_RS25380	COG1846	Transcriptional regulator
HUT12_RS25385	COG0432	Pfam Uncharacterised protein family UPF0047
HUT12_RS25390	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HUT12_RS25415	COG2814	Major facilitator Superfamily
HUT12_RS25420	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HUT12_RS25445	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HUT12_RS25450	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUT12_RS25475	COG0288	reversible hydration of carbon dioxide
HUT12_RS25485	COG3973	AAA domain
HUT12_RS25495	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HUT12_RS25495	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HUT12_RS25525	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HUT12_RS25525	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HUT12_RS25545	COG3268	Saccharopine dehydrogenase
HUT12_RS25550	COG0789	Transcriptional regulator
HUT12_RS25555	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HUT12_RS25600	COG0277	FAD linked oxidase domain protein
HUT12_RS25635	COG1131	(ABC) transporter
HUT12_RS25670	COG4941	Belongs to the sigma-70 factor family
HUT12_RS25735	COG1940	carbohydrate kinase activity
HUT12_RS25785	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HUT12_RS25810	COG1172	Belongs to the binding-protein-dependent transport system permease family
HUT12_RS25815	COG1129	ABC transporter
HUT12_RS25845	COG2018	Roadblock/LC7 domain
HUT12_RS25850	COG2358	TRAP transporter, solute receptor (TAXI family
HUT12_RS25880	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HUT12_RS25890	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HUT12_RS25905	COG0574	Belongs to the PEP-utilizing enzyme family
HUT12_RS25905	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HUT12_RS25930	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HUT12_RS25935	COG0740	serine-type endopeptidase activity
HUT12_RS25940	COG0740	serine-type endopeptidase activity
HUT12_RS25945	COG0544	peptidyl-prolyl cis-trans isomerase activity
HUT12_RS25970	COG2746	aminoglycoside 3-N-acetyltransferase activity
HUT12_RS25990	COG4552	Acetyltransferase involved in intracellular survival and related
HUT12_RS26000	COG0698	ribose 5-phosphate isomerase
HUT12_RS26010	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HUT12_RS26020	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HUT12_RS26030	COG0154	amidase activity
HUT12_RS26040	COG4101	3-hydroxyanthranilate 3,4-dioxygenase activity
HUT12_RS26055	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HUT12_RS26060	COG4569	acetaldehyde dehydrogenase (acetylating) activity
HUT12_RS26075	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUT12_RS26080	COG3844	kynureninase activity
HUT12_RS26085	COG3483	tryptophan 2,3-dioxygenase activity
HUT12_RS26090	COG1522	sequence-specific DNA binding
HUT12_RS26110	COG0668	transmembrane transport
HUT12_RS26120	COG2346	COG2346, Truncated hemoglobins
HUT12_RS26145	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HUT12_RS26150	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUT12_RS26150	COG0561	phosphatase activity
HUT12_RS26160	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HUT12_RS26160	COG1648	precorrin-2 dehydrogenase activity
HUT12_RS26165	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HUT12_RS26180	COG1797	cobyrinic acid a,c-diamide synthase activity
HUT12_RS26190	COG1793	dna ligase
HUT12_RS26200	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUT12_RS26215	COG1492	cobalamin metabolic process
HUT12_RS26220	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HUT12_RS26225	COG0629	single-stranded DNA binding
HUT12_RS26280	COG2197	response regulator
HUT12_RS26335	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HUT12_RS26365	COG1566	PFAM secretion protein HlyD family protein
HUT12_RS26390	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HUT12_RS26395	COG1737	Transcriptional regulator
HUT12_RS26400	COG1028	Short-chain dehydrogenase reductase Sdr
HUT12_RS26405	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HUT12_RS26430	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
HUT12_RS26435	COG1653	transport
HUT12_RS26440	COG1175	transmembrane transport
HUT12_RS26445	COG0395	ABC-type sugar transport system, permease component
HUT12_RS26450	COG1609	Transcriptional regulator
HUT12_RS26455	COG0366	Alpha amylase catalytic
HUT12_RS26460	COG2814	Major facilitator Superfamily
HUT12_RS26465	COG1070	Carbohydrate kinase
HUT12_RS26470	COG2115	Belongs to the xylose isomerase family
HUT12_RS26545	COG5297	Belongs to the glycosyl hydrolase family 6
HUT12_RS26560	COG2902	Dehydrogenase
HUT12_RS26580	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUT12_RS26580	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUT12_RS26595	COG0183	Belongs to the thiolase family
HUT12_RS26600	COG0346	lactoylglutathione lyase activity
HUT12_RS26645	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUT12_RS26650	COG1716	ATPase activity
HUT12_RS26665	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
HUT12_RS26685	COG1131	(ABC) transporter
HUT12_RS26695	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUT12_RS26700	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HUT12_RS26715	COG2755	lipolytic protein G-D-S-L family
HUT12_RS26725	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HUT12_RS26735	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HUT12_RS26740	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HUT12_RS26745	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HUT12_RS26750	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HUT12_RS26755	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HUT12_RS26760	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HUT12_RS26765	COG0356	it plays a direct role in the translocation of protons across the membrane
HUT12_RS26780	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HUT12_RS26785	COG0702	epimerase
HUT12_RS26790	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HUT12_RS26795	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HUT12_RS26800	COG0009	L-threonylcarbamoyladenylate synthase
HUT12_RS26805	COG2890	protein-(glutamine-N5) methyltransferase activity
HUT12_RS26810	COG3706	GGDEF domain
HUT12_RS26815	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HUT12_RS26820	COG0254	rRNA binding
HUT12_RS26830	COG0083	homoserine kinase activity
HUT12_RS26845	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HUT12_RS26850	COG1132	(ABC) transporter
HUT12_RS26855	COG1309	transcriptional regulator
HUT12_RS26865	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HUT12_RS26870	COG0460	homoserine dehydrogenase
HUT12_RS26875	COG0019	diaminopimelate decarboxylase activity
HUT12_RS26880	COG0018	arginyl-trna synthetase
HUT12_RS26920	COG1793	dna ligase
HUT12_RS26920	COG3285	dna ligase
HUT12_RS26935	COG2409	Drug exporters of the RND superfamily
HUT12_RS26950	COG0673	inositol 2-dehydrogenase activity
HUT12_RS26970	COG0366	Alpha amylase catalytic
HUT12_RS26980	COG0586	Pfam SNARE associated Golgi protein
HUT12_RS26995	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HUT12_RS27000	COG0446	pyridine nucleotide-disulphide oxidoreductase
HUT12_RS27055	COG1834	amidinotransferase
HUT12_RS27060	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HUT12_RS27070	COG2154	pterin-4-alpha-carbinolamine dehydratase
HUT12_RS27095	COG0515	serine threonine protein kinase
HUT12_RS27110	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUT12_RS27115	COG2205	protein histidine kinase activity
HUT12_RS27120	COG0745	RESPONSE REGULATOR receiver
HUT12_RS27140	COG1131	(ABC) transporter
HUT12_RS27150	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUT12_RS27150	COG0567	Dehydrogenase, E1 component
HUT12_RS27175	COG0280	phosphate acetyltransferase
HUT12_RS27175	COG0857	belongs to the CobB CobQ family
HUT12_RS27180	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HUT12_RS27220	COG2172	sigma factor antagonist activity
HUT12_RS27230	COG1597	lipid kinase activity
HUT12_RS27245	COG0175	sulfate reduction
HUT12_RS27270	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HUT12_RS27285	COG1309	transcriptional regulator
HUT12_RS27295	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HUT12_RS27300	COG5662	AntiSigma factor
HUT12_RS27305	COG1595	DNA-templated transcription, initiation
HUT12_RS27325	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HUT12_RS27335	COG0483	inositol monophosphate 1-phosphatase activity
HUT12_RS27345	COG0438	transferase activity, transferring glycosyl groups
HUT12_RS27360	COG4585	Histidine kinase
HUT12_RS27370	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HUT12_RS27390	COG1615	UPF0182 protein
HUT12_RS27395	COG3480	Lon protease (S16) C-terminal proteolytic domain
HUT12_RS27425	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HUT12_RS27495	COG1278	Cold shock
HUT12_RS27510	COG1611	Belongs to the LOG family
HUT12_RS27515	COG1611	Belongs to the LOG family
HUT12_RS27525	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUT12_RS27530	COG2171	N-acyltransferase activity
HUT12_RS27535	COG1404	Belongs to the peptidase S8 family
HUT12_RS27540	COG0110	maltose O-acetyltransferase activity
HUT12_RS27560	COG0287	Prephenate dehydrogenase
HUT12_RS27590	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HUT12_RS27635	COG2154	pterin-4-alpha-carbinolamine dehydratase
HUT12_RS27645	COG2226	methyltransferase
HUT12_RS27650	COG2949	membrane
HUT12_RS27665	COG0012	GTP binding
HUT12_RS27680	COG2169	Transcriptional regulator
HUT12_RS27680	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HUT12_RS27685	COG1132	(ABC) transporter
HUT12_RS27690	COG1132	(ABC) transporter
HUT12_RS27695	COG0525	valine-tRNA ligase activity
HUT12_RS27715	COG1131	(ABC) transporter
HUT12_RS27725	COG0529	Catalyzes the synthesis of activated sulfate
HUT12_RS27730	COG1349	DNA-binding transcription factor activity
HUT12_RS27760	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HUT12_RS27765	COG0747	negative chemotaxis
HUT12_RS27770	COG0601	transmembrane transport
HUT12_RS27775	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUT12_RS27780	COG0444	Belongs to the ABC transporter superfamily
HUT12_RS27785	COG4608	Belongs to the ABC transporter superfamily
HUT12_RS27790	COG0138	bifunctional purine biosynthesis protein purh
HUT12_RS27825	COG0045	succinate-CoA ligase (ADP-forming) activity
HUT12_RS27830	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUT12_RS27835	COG0739	heme binding
HUT12_RS27840	COG1196	nuclear chromosome segregation
HUT12_RS27840	COG0739	heme binding
HUT12_RS27840	COG0741	lytic transglycosylase activity
HUT12_RS27850	COG1605	Chorismate mutase
HUT12_RS27855	COG4608	Belongs to the ABC transporter superfamily
HUT12_RS27860	COG0444	Belongs to the ABC transporter superfamily
HUT12_RS27870	COG0601	transmembrane transport
HUT12_RS27880	COG2197	response regulator
HUT12_RS27885	COG4585	Histidine kinase
HUT12_RS27900	COG0688	phosphatidylethanolamine metabolic process
HUT12_RS27905	COG1183	phosphatidylcholine synthase activity
HUT12_RS27915	COG1051	belongs to the nudix hydrolase family
HUT12_RS27925	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HUT12_RS27925	COG0519	Catalyzes the synthesis of GMP from XMP
HUT12_RS27935	COG1316	TRANSCRIPTIONal
HUT12_RS27945	COG0516	GMP reductase activity
HUT12_RS27960	COG2197	response regulator
HUT12_RS27975	COG0459	protein refolding
HUT12_RS27980	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HUT12_RS28005	COG4213	ABC transporter substrate-binding protein
HUT12_RS28015	COG4214	carbohydrate transport
HUT12_RS28040	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HUT12_RS28050	COG0456	acetyltransferase
HUT12_RS28050	COG1214	PFAM Peptidase M22, glycoprotease
HUT12_RS28055	COG1595	DNA-templated transcription, initiation
HUT12_RS28065	COG1404	Belongs to the peptidase S8 family
HUT12_RS28070	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HUT12_RS28075	COG0802	atpase or kinase
HUT12_RS28085	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HUT12_RS28105	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HUT12_RS28115	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HUT12_RS28120	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HUT12_RS28125	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HUT12_RS28130	COG2223	nitrite transmembrane transporter activity
HUT12_RS28145	COG2813	Specifically methylates the guanine in position
HUT12_RS28150	COG0243	molybdopterin cofactor binding
HUT12_RS28155	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUT12_RS28160	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUT12_RS28160	COG2146	nitrite reductase [NAD(P)H] activity
HUT12_RS28165	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUT12_RS28165	COG2146	nitrite reductase [NAD(P)H] activity
HUT12_RS28185	COG2018	Roadblock/LC7 domain
HUT12_RS28200	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUT12_RS28230	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HUT12_RS28235	COG0351	phosphomethylpyrimidine kinase
HUT12_RS28240	COG0352	thiamine-phosphate diphosphorylase activity
HUT12_RS28245	COG2022	thiamine diphosphate biosynthetic process
HUT12_RS28255	COG2022	thiamine diphosphate biosynthetic process
HUT12_RS28255	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HUT12_RS28260	COG0352	thiamine-phosphate diphosphorylase activity
HUT12_RS28270	COG0667	Aldo Keto reductase
HUT12_RS28275	COG0488	(ABC) transporter
HUT12_RS28280	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HUT12_RS28290	COG0101	tRNA pseudouridine synthase activity
HUT12_RS28295	COG0203	ribosomal protein L17
HUT12_RS28300	COG0202	RNA polymerase activity
HUT12_RS28305	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HUT12_RS28310	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HUT12_RS28315	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HUT12_RS28320	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HUT12_RS28325	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HUT12_RS28340	COG0563	adenylate kinase activity
HUT12_RS28350	COG0200	Binds to the 23S rRNA
HUT12_RS28355	COG1841	ribosomal large subunit assembly
HUT12_RS28360	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HUT12_RS28365	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HUT12_RS28370	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HUT12_RS28375	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HUT12_RS28380	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HUT12_RS28385	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HUT12_RS28390	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HUT12_RS28395	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HUT12_RS28400	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HUT12_RS28405	COG0255	Belongs to the universal ribosomal protein uL29 family
HUT12_RS28410	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HUT12_RS28415	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HUT12_RS28420	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HUT12_RS28425	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HUT12_RS28430	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HUT12_RS28440	COG0088	Forms part of the polypeptide exit tunnel
HUT12_RS28445	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HUT12_RS28450	COG0051	transcription antitermination factor activity, RNA binding
HUT12_RS28455	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HUT12_RS28460	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HUT12_RS28465	COG0049	tRNA binding
HUT12_RS28470	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HUT12_RS28485	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HUT12_RS28490	COG0085	RNA polymerase activity
HUT12_RS28495	COG0222	ribosome binding
HUT12_RS28510	COG1121	(ABC) transporter
HUT12_RS28515	COG0081	regulation of translation
HUT12_RS28520	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HUT12_RS28545	COG2030	dehydratase
HUT12_RS28550	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HUT12_RS28580	COG1666	GTP binding
HUT12_RS28585	COG1028	Short-chain dehydrogenase reductase Sdr
HUT12_RS28590	COG1309	transcriptional regulator
HUT12_RS28600	COG0501	Belongs to the peptidase M48B family
HUT12_RS28605	COG1007	ATP synthesis coupled electron transport
HUT12_RS28610	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUT12_RS28620	COG0713	ATP synthesis coupled electron transport
HUT12_RS28625	COG0839	Belongs to the complex I subunit 6 family
HUT12_RS28630	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUT12_RS28635	COG0435	Glutathione S-transferase
HUT12_RS28640	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HUT12_RS28645	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUT12_RS28650	COG1063	alcohol dehydrogenase
HUT12_RS28660	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUT12_RS28670	COG2211	Major facilitator Superfamily
HUT12_RS28680	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HUT12_RS28685	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HUT12_RS28735	COG0513	Belongs to the DEAD box helicase family
HUT12_RS28765	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HUT12_RS28770	COG0569	domain protein
HUT12_RS28775	COG0515	serine threonine protein kinase
HUT12_RS28790	COG0483	inositol monophosphate 1-phosphatase activity
HUT12_RS28795	COG0784	Response regulator, receiver
HUT12_RS28800	COG4251	negative regulation of phosphorylation
HUT12_RS28805	COG0745	RESPONSE REGULATOR receiver
HUT12_RS28810	COG2234	aminopeptidase activity
HUT12_RS28830	COG0488	(ABC) transporter
HUT12_RS28835	COG2226	methyltransferase
HUT12_RS28860	COG0456	acetyltransferase
HUT12_RS28870	COG0113	porphobilinogen synthase activity
HUT12_RS28875	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HUT12_RS28875	COG1648	precorrin-2 dehydrogenase activity
HUT12_RS28880	COG0181	hydroxymethylbilane synthase activity
HUT12_RS28885	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HUT12_RS28890	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HUT12_RS28905	COG0318	PFAM AMP-dependent synthetase and ligase
HUT12_RS28910	COG1595	DNA-templated transcription, initiation
HUT12_RS28920	COG0560	Phosphoserine phosphatase
HUT12_RS28945	COG1136	(ABC) transporter
HUT12_RS28945	COG0577	efflux transmembrane transporter activity
HUT12_RS28950	COG0577	efflux transmembrane transporter activity
HUT12_RS28950	COG1136	(ABC) transporter
HUT12_RS28970	COG0596	Alpha beta hydrolase
HUT12_RS28975	COG0506	proline dehydrogenase activity
HUT12_RS29000	COG0423	glycine-tRNA ligase activity
HUT12_RS29020	COG0803	Belongs to the bacterial solute-binding protein 9 family
HUT12_RS29020	COG3443	Belongs to the bacterial solute-binding protein 9 family
HUT12_RS29025	COG1121	(ABC) transporter
HUT12_RS29030	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HUT12_RS29055	COG4821	SIS domain
HUT12_RS29060	COG0596	Alpha beta hydrolase
HUT12_RS29070	COG0701	Predicted permease
HUT12_RS29075	COG4721	ABC-type cobalt transport system, permease component
HUT12_RS29080	COG4172	Belongs to the ABC transporter superfamily
HUT12_RS29095	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HUT12_RS29105	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HUT12_RS29110	COG1381	Involved in DNA repair and RecF pathway recombination
HUT12_RS29125	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HUT12_RS29140	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HUT12_RS29155	COG0537	adenosine 5'-monophosphoramidase activity
HUT12_RS29160	COG1028	Short-chain dehydrogenase reductase Sdr
HUT12_RS29170	COG0484	heat shock protein binding
HUT12_RS29175	COG1420	regulation of RNA biosynthetic process
HUT12_RS29190	COG1024	Enoyl-CoA hydratase
HUT12_RS29210	COG0395	ABC-type sugar transport system, permease component
HUT12_RS29215	COG1175	transmembrane transport
HUT12_RS29235	COG0481	GTPase activity
HUT12_RS29250	COG0268	Binds directly to 16S ribosomal RNA
HUT12_RS29265	COG2333	competence protein COMEC
HUT12_RS29265	COG0658	competence protein
HUT12_RS29270	COG1555	photosystem II stabilization
HUT12_RS29270	COG1596	polysaccharide export
HUT12_RS29280	COG1307	EDD domain protein, DegV family
HUT12_RS29285	COG0406	alpha-ribazole phosphatase activity
HUT12_RS29290	COG0799	negative regulation of ribosome biogenesis
HUT12_RS29295	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HUT12_RS29315	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HUT12_RS29320	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HUT12_RS29325	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HUT12_RS29330	COG1530	ribonuclease E activity
HUT12_RS29350	COG0204	Acyl-transferase
HUT12_RS29355	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HUT12_RS29360	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HUT12_RS29365	COG1595	DNA-templated transcription, initiation
HUT12_RS29370	COG0105	UTP biosynthetic process
HUT12_RS29385	COG0285	dihydrofolate synthase activity
HUT12_RS29390	COG0525	valine-tRNA ligase activity
HUT12_RS29430	COG0754	glutathionylspermidine amidase activity
HUT12_RS29440	COG1082	Xylose isomerase domain protein TIM barrel
HUT12_RS29445	COG0248	Ppx GppA phosphatase
HUT12_RS29460	COG5002	protein histidine kinase activity
HUT12_RS29470	COG0588	phosphoglycerate mutase activity
HUT12_RS29495	COG0438	transferase activity, transferring glycosyl groups
HUT12_RS29505	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HUT12_RS29525	COG0395	ABC-type sugar transport system, permease component
HUT12_RS29540	COG0251	oxidation-reduction process
HUT12_RS29555	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HUT12_RS29570	COG1131	(ABC) transporter
HUT12_RS29580	COG4585	Histidine kinase
HUT12_RS29585	COG2197	response regulator
HUT12_RS29600	COG0513	Belongs to the DEAD box helicase family
HUT12_RS29645	COG3246	L-lysine catabolic process to acetate
HUT12_RS29650	COG0354	folic acid binding
HUT12_RS29655	COG0735	belongs to the Fur family
HUT12_RS29665	COG4044	May play a role in the intracellular transport of hydrophobic ligands
HUT12_RS29695	COG1404	Belongs to the peptidase S8 family
HUT12_RS29695	COG4412	M6 family metalloprotease domain protein
HUT12_RS29715	COG2897	thiosulfate sulfurtransferase activity
HUT12_RS29730	COG0745	RESPONSE REGULATOR receiver
HUT12_RS29735	COG0726	polysaccharide deacetylase
HUT12_RS29740	COG0456	acetyltransferase
HUT12_RS29765	COG2326	polyphosphate kinase activity
HUT12_RS29795	COG2339	peptidase activity
HUT12_RS29800	COG4129	membrane
HUT12_RS29815	COG0277	FAD linked oxidase domain protein
HUT12_RS29845	COG0459	protein refolding
HUT12_RS29855	COG1278	Cold shock
HUT12_RS29865	COG1012	belongs to the aldehyde dehydrogenase family
HUT12_RS29870	COG0456	acetyltransferase
HUT12_RS29875	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HUT12_RS29895	COG1131	(ABC) transporter
HUT12_RS29910	COG2018	Roadblock/LC7 domain
HUT12_RS29930	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HUT12_RS29935	COG1247	-acetyltransferase
HUT12_RS29955	COG1131	(ABC) transporter
HUT12_RS29960	COG1349	DNA-binding transcription factor activity
HUT12_RS29965	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HUT12_RS29970	COG1940	carbohydrate kinase activity
HUT12_RS30015	COG1216	Glycosyl transferase, family 2
HUT12_RS30040	COG3842	ATPase activity
HUT12_RS30045	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HUT12_RS30050	COG0215	cysteine-tRNA ligase activity
HUT12_RS30065	COG1404	Belongs to the peptidase S8 family
HUT12_RS30070	COG1011	Hydrolase
HUT12_RS30085	COG0114	fumarate hydratase activity
HUT12_RS30095	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HUT12_RS30095	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HUT12_RS30120	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HUT12_RS30135	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HUT12_RS30170	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HUT12_RS30175	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HUT12_RS30210	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HUT12_RS30225	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HUT12_RS30230	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HUT12_RS30240	COG0242	peptide deformylase activity
HUT12_RS30245	COG3830	Belongs to the UPF0237 family
HUT12_RS30270	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HUT12_RS30280	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HUT12_RS30290	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HUT12_RS30300	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HUT12_RS30305	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HUT12_RS30320	COG0649	NAD binding
HUT12_RS30335	COG1174	glycine betaine transport
HUT12_RS30340	COG1174	glycine betaine transport
HUT12_RS30375	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HUT12_RS30410	COG0739	heme binding
HUT12_RS30410	COG1196	nuclear chromosome segregation
HUT12_RS30410	COG0741	lytic transglycosylase activity
HUT12_RS30435	COG0302	gtp cyclohydrolase
HUT12_RS30440	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HUT12_RS30455	COG4977	sequence-specific DNA binding
HUT12_RS30460	COG0405	Gamma-glutamyltransferase
HUT12_RS30465	COG0037	tRNA processing
HUT12_RS30475	COG2027	D-alanyl-D-alanine carboxypeptidase
HUT12_RS30480	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HUT12_RS30490	COG1674	ftsk spoiiie
HUT12_RS30500	COG0671	phosphoesterase, PA-phosphatase related
HUT12_RS30515	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUT12_RS30520	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HUT12_RS30555	COG1960	acyl-CoA dehydrogenase activity
HUT12_RS30560	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HUT12_RS30610	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUT12_RS30650	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HUT12_RS30655	COG1610	YqeY-like protein
HUT12_RS30660	COG1408	metallophosphoesterase
HUT12_RS30680	COG2192	nodulation
HUT12_RS30690	COG1280	lysine exporter protein (LysE YggA)
HUT12_RS30720	COG0133	tryptophan synthase activity
HUT12_RS30725	COG0159	tryptophan synthase activity
HUT12_RS30730	COG2188	Transcriptional regulator
HUT12_RS30740	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HUT12_RS30790	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HUT12_RS30795	COG0477	Major facilitator Superfamily
HUT12_RS30810	COG4608	Belongs to the ABC transporter superfamily
HUT12_RS30830	COG0747	negative chemotaxis
HUT12_RS30835	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HUT12_RS30840	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HUT12_RS30930	COG0813	purine-nucleoside phosphorylase activity
HUT12_RS30945	COG0590	tRNA wobble adenosine to inosine editing
HUT12_RS30975	COG1796	DNA polymerase
HUT12_RS30975	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HUT12_RS30995	COG4981	capsule polysaccharide biosynthetic process
HUT12_RS31005	COG0438	transferase activity, transferring glycosyl groups
HUT12_RS31125	COG1674	ftsk spoiiie
HUT12_RS31140	COG1404	Belongs to the peptidase S8 family
HUT12_RS31165	COG0464	growth
HUT12_RS31180	COG0738	Major facilitator superfamily
HUT12_RS31215	COG0019	diaminopimelate decarboxylase activity
HUT12_RS31220	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUT12_RS31240	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUT12_RS31250	COG0483	inositol monophosphate 1-phosphatase activity
HUT12_RS31260	COG3629	intracellular signal transduction
HUT12_RS31260	COG3903	Transcriptional regulator
HUT12_RS31285	COG3852	Histidine kinase
HUT12_RS31315	COG1309	transcriptional regulator
HUT12_RS31400	COG2755	lipolytic protein G-D-S-L family
HUT12_RS31400	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HUT12_RS31450	COG0242	peptide deformylase activity
HUT12_RS31470	COG1881	PFAM PEBP family protein
HUT12_RS31490	COG0789	Transcriptional regulator
HUT12_RS31495	COG3959	Transketolase, thiamine diphosphate binding domain
HUT12_RS31500	COG3958	Transketolase
HUT12_RS31505	COG0463	Glycosyl transferase, family 2
HUT12_RS31530	COG0183	Belongs to the thiolase family
HUT12_RS31540	COG0705	Rhomboid family
HUT12_RS31555	COG0598	Magnesium transport protein CorA
HUT12_RS31560	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUT12_RS31585	COG0371	Dehydrogenase
HUT12_RS31600	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HUT12_RS31605	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HUT12_RS31610	COG3275	phosphorelay sensor kinase activity
HUT12_RS31630	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HUT12_RS31670	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HUT12_RS31675	COG1088	dTDP-glucose 4,6-dehydratase activity
HUT12_RS31705	COG5002	protein histidine kinase activity
HUT12_RS31740	COG0077	Prephenate dehydratase
HUT12_RS31755	COG1764	response to oxidative stress
HUT12_RS31765	COG0561	phosphatase activity
HUT12_RS31770	COG0561	phosphatase activity
HUT12_RS31790	COG1834	amidinotransferase
HUT12_RS31795	COG1522	sequence-specific DNA binding
HUT12_RS31820	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HUT12_RS31850	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HUT12_RS31860	COG1408	metallophosphoesterase
HUT12_RS31905	COG0521	Mo-molybdopterin cofactor biosynthetic process
HUT12_RS31910	COG0315	cyclic pyranopterin monophosphate synthase activity
HUT12_RS31915	COG3629	intracellular signal transduction
HUT12_RS31915	COG3903	Transcriptional regulator
HUT12_RS31940	COG0305	Participates in initiation and elongation during chromosome replication
HUT12_RS31950	COG0359	binds to the 23S rRNA
HUT12_RS31955	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HUT12_RS31965	COG0360	Binds together with S18 to 16S ribosomal RNA
HUT12_RS31970	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HUT12_RS31985	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HUT12_RS31995	COG1695	Transcriptional regulator
HUT12_RS32000	COG1260	myo-inositol-1-phosphate synthase
HUT12_RS32005	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HUT12_RS32015	COG0617	tRNA 3'-terminal CCA addition
HUT12_RS32030	COG1595	DNA-templated transcription, initiation
HUT12_RS32045	COG3118	belongs to the thioredoxin family
HUT12_RS32050	COG3409	Peptidoglycan-binding domain 1 protein
HUT12_RS32050	COG0860	N-Acetylmuramoyl-L-alanine amidase
HUT12_RS32060	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUT12_RS32065	COG1181	Belongs to the D-alanine--D-alanine ligase family
HUT12_RS32080	COG1192	Involved in chromosome partitioning
HUT12_RS32085	COG0357	Ribosomal RNA small subunit methyltransferase G
HUT12_RS32095	COG0706	membrane insertase activity
HUT12_RS32100	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HUT12_RS32105	COG0594	ribonuclease P activity
HUT12_RS32110	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HUT12_RS32120	COG0592	DNA-directed DNA polymerase activity
HUT12_RS32125	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HUT12_RS32130	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HUT12_RS32135	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
HUT12_RS32145	COG0187	DNA topoisomerase II activity
HUT12_RS32155	COG3293	Transposase
HUT12_RS32255	COG0739	heme binding
HUT12_RS32400	COG2188	Transcriptional regulator
HUT12_RS32445	COG1674	ftsk spoiiie