locus-tag	class	description
VA249_RS00010	COG0592	DNA-directed DNA polymerase activity
VA249_RS00020	COG0187	DNA topoisomerase II activity
VA249_RS00025	COG0071	Belongs to the small heat shock protein (HSP20) family
VA249_RS00030	COG3977	Valine--pyruvate aminotransferase
VA249_RS00050	COG4964	Belongs to the GSP D family
VA249_RS00125	COG2119	membrane
VA249_RS00135	COG0425	Belongs to the sulfur carrier protein TusA family
VA249_RS00150	COG0604	alcohol dehydrogenase
VA249_RS00155	COG0183	Belongs to the thiolase family
VA249_RS00165	COG1739	Uncharacterized protein family UPF0029
VA249_RS00170	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VA249_RS00220	COG0583	DNA-binding transcription factor activity
VA249_RS00225	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
VA249_RS00230	COG2960	long-chain fatty acid transporting porin activity
VA249_RS00235	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VA249_RS00240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VA249_RS00245	COG1309	transcriptional regulator
VA249_RS00295	COG0747	negative chemotaxis
VA249_RS00300	COG0601	transmembrane transport
VA249_RS00305	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VA249_RS00340	COG1609	Transcriptional regulator
VA249_RS00345	COG0583	DNA-binding transcription factor activity
VA249_RS00350	COG2076	Multidrug Resistance protein
VA249_RS00360	COG0129	dihydroxy-acid dehydratase activity
VA249_RS00365	COG3265	gluconokinase activity
VA249_RS00370	COG2610	gluconate transmembrane transporter activity
VA249_RS00375	COG0800	Aldolase
VA249_RS00380	COG0251	oxidation-reduction process
VA249_RS00390	COG1301	dicarboxylic acid transport
VA249_RS00400	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VA249_RS00405	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
VA249_RS00415	COG1522	sequence-specific DNA binding
VA249_RS00435	COG0589	response to stress
VA249_RS00440	COG1528	Iron-storage protein
VA249_RS00450	COG2081	HI0933 family
VA249_RS00455	COG5001	Diguanylate cyclase
VA249_RS00455	COG3300	MHYT domain
VA249_RS00465	COG1322	Protein conserved in bacteria
VA249_RS00475	COG3165	ubiquinone biosynthetic process from chorismate
VA249_RS00490	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VA249_RS00495	COG0805	protein transport
VA249_RS00500	COG0084	hydrolase, TatD family'
VA249_RS00515	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VA249_RS00515	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VA249_RS00520	COG0218	Necessary for normal cell division and for the maintenance of normal septation
VA249_RS00550	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
VA249_RS00560	COG2204	response regulator
VA249_RS00565	COG3852	Histidine kinase
VA249_RS00575	COG0174	glutamine synthetase
VA249_RS00580	COG1217	gtp-binding protein TYPA
VA249_RS00600	COG1490	D-aminoacyl-tRNA deacylase activity
VA249_RS00605	COG0456	acetyltransferase
VA249_RS00625	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
VA249_RS00630	COG3031	protein transport across the cell outer membrane
VA249_RS00640	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VA249_RS00650	COG2165	general secretion pathway protein
VA249_RS00655	COG2165	general secretion pathway protein
VA249_RS00660	COG2165	general secretion pathway protein
VA249_RS00665	COG4795	General secretion pathway protein
VA249_RS00670	COG3156	type II secretion system protein K
VA249_RS00675	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VA249_RS00680	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VA249_RS00690	COG1218	3'(2'),5'-bisphosphate nucleotidase
VA249_RS00695	COG0494	nUDIX hydrolase
VA249_RS00720	COG2183	response to ionizing radiation
VA249_RS00745	COG2233	PERMEase
VA249_RS00750	COG0823	Involved in the tonB-independent uptake of proteins
VA249_RS00750	COG1506	peptidase
VA249_RS00750	COG4946	Tricorn protease homolog
VA249_RS00755	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
VA249_RS00760	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VA249_RS00765	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VA249_RS00770	COG1758	RNA polymerase activity
VA249_RS00775	COG0194	GDP metabolic process
VA249_RS00795	COG0848	biopolymer transport protein
VA249_RS00800	COG0811	peptide transport
VA249_RS00820	COG4174	ABC transporter (Permease)
VA249_RS00825	COG4239	(ABC) transporter, permease
VA249_RS00830	COG0747	negative chemotaxis
VA249_RS00835	COG0444	Belongs to the ABC transporter superfamily
VA249_RS00840	COG4608	Belongs to the ABC transporter superfamily
VA249_RS00870	COG2246	polysaccharide biosynthetic process
VA249_RS00880	COG1561	YicC-like family, N-terminal region
VA249_RS00885	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
VA249_RS00890	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
VA249_RS00895	COG1560	Kdo2-lipid A biosynthetic process
VA249_RS00900	COG1309	transcriptional regulator
VA249_RS00905	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
VA249_RS00915	COG0227	Belongs to the bacterial ribosomal protein bL28 family
VA249_RS00940	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
VA249_RS00950	COG0463	Glycosyl transferase, family 2
VA249_RS00955	COG0859	PFAM glycosyl transferase family 9
VA249_RS00960	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
VA249_RS00965	COG3642	lipopolysaccharide core region biosynthetic process
VA249_RS00995	COG1028	Short-chain dehydrogenase reductase Sdr
VA249_RS01000	COG1021	2,3-dihydroxybenzoate-AMP ligase
VA249_RS01010	COG0463	Glycosyl transferase, family 2
VA249_RS01030	COG1519	Transferase
VA249_RS01035	COG0859	PFAM glycosyl transferase family 9
VA249_RS01040	COG1560	Kdo2-lipid A biosynthetic process
VA249_RS01050	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VA249_RS01095	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
VA249_RS01150	COG1215	transferase activity, transferring glycosyl groups
VA249_RS01160	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VA249_RS01170	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
VA249_RS01190	COG0149	triose-phosphate isomerase activity
VA249_RS01215	COG1494	fructose-1,6-bisphosphatase
VA249_RS01220	COG3074	FtsZ-dependent cytokinesis
VA249_RS01225	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VA249_RS01230	COG1575	Belongs to the MenA family. Type 1 subfamily
VA249_RS01250	COG1609	Transcriptional regulator
VA249_RS01255	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
VA249_RS01260	COG0254	rRNA binding
VA249_RS01270	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
VA249_RS01275	COG0088	Forms part of the polypeptide exit tunnel
VA249_RS01285	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
VA249_RS01290	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
VA249_RS01315	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
VA249_RS01320	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
VA249_RS01325	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
VA249_RS01330	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
VA249_RS01335	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
VA249_RS01345	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
VA249_RS01360	COG1841	ribosomal large subunit assembly
VA249_RS01370	COG0201	protein transport
VA249_RS01380	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
VA249_RS01385	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
VA249_RS01395	COG0202	RNA polymerase activity
VA249_RS01400	COG0203	ribosomal protein L17
VA249_RS01410	COG0545	Peptidyl-prolyl cis-trans isomerase
VA249_RS01420	COG2153	protein acetylation
VA249_RS01425	COG0513	Belongs to the DEAD box helicase family
VA249_RS01435	COG0737	Belongs to the 5'-nucleotidase family
VA249_RS01440	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VA249_RS01440	COG1648	precorrin-2 dehydrogenase activity
VA249_RS01455	COG0471	metal ion transport
VA249_RS01455	COG3273	potassium ion transport
VA249_RS01460	COG0529	Catalyzes the synthesis of activated sulfate
VA249_RS01480	COG4181	ATPase activity
VA249_RS01495	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
VA249_RS01505	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VA249_RS01510	COG0729	surface antigen
VA249_RS01520	COG2105	PFAM AIG2 family protein
VA249_RS01525	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
VA249_RS01530	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
VA249_RS01535	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VA249_RS01540	COG0163	prenyltransferase activity
VA249_RS01545	COG4143	(ABC) transporter
VA249_RS01550	COG1178	ABC-type Fe3 transport system permease component
VA249_RS01555	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
VA249_RS01570	COG2358	TRAP transporter, solute receptor (TAXI family
VA249_RS01590	COG0142	geranyltranstransferase activity
VA249_RS01595	COG0261	This protein binds to 23S rRNA in the presence of protein L20
VA249_RS01605	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
VA249_RS01615	COG2966	Psort location CytoplasmicMembrane, score
VA249_RS01620	COG3610	response to peptide
VA249_RS01625	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
VA249_RS01635	COG2967	ApaG domain
VA249_RS01645	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
VA249_RS01650	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VA249_RS01655	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
VA249_RS01660	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
VA249_RS01680	COG0473	3-isopropylmalate dehydrogenase activity
VA249_RS01685	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VA249_RS01705	COG0583	DNA-binding transcription factor activity
VA249_RS01710	COG1022	Amp-dependent synthetase and ligase
VA249_RS01715	COG0028	Belongs to the TPP enzyme family
VA249_RS01725	COG3706	GGDEF domain
VA249_RS01735	COG0469	pyruvate kinase activity
VA249_RS01740	COG1349	DNA-binding transcription factor activity
VA249_RS01745	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
VA249_RS01770	COG4974	Belongs to the 'phage' integrase family
VA249_RS01820	COG0358	DNA primase activity
VA249_RS01825	COG1610	YqeY-like protein
VA249_RS01830	COG0828	Belongs to the bacterial ribosomal protein bS21 family
VA249_RS01835	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
VA249_RS01840	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
VA249_RS01845	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
VA249_RS01850	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
VA249_RS01870	COG3409	Peptidoglycan-binding domain 1 protein
VA249_RS01870	COG3267	Type II secretory pathway component ExeA
VA249_RS01880	COG4991	sh3 domain protein
VA249_RS01885	COG0306	phosphate transporter
VA249_RS01890	COG1392	Phosphate transport regulator
VA249_RS01895	COG3025	triphosphatase activity
VA249_RS01900	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VA249_RS01910	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
VA249_RS01920	COG1538	Outer membrane efflux protein
VA249_RS01925	COG0494	nUDIX hydrolase
VA249_RS01930	COG3151	Protein conserved in bacteria
VA249_RS01940	COG3150	esterase
VA249_RS01950	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
VA249_RS01965	COG3105	Protein conserved in bacteria
VA249_RS01970	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
VA249_RS01985	COG0723	plastoquinol--plastocyanin reductase activity
VA249_RS01990	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
VA249_RS01995	COG2857	Cytochrome c1
VA249_RS02000	COG0625	glutathione transferase activity
VA249_RS02005	COG2969	positive regulation of protein catabolic process
VA249_RS02010	COG2823	Periplasmic or secreted lipoprotein
VA249_RS02015	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VA249_RS02030	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
VA249_RS02045	COG3116	cell division
VA249_RS02050	COG0768	penicillin binding
VA249_RS02055	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
VA249_RS02060	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
VA249_RS02065	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VA249_RS02075	COG0772	Belongs to the SEDS family
VA249_RS02090	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
VA249_RS02095	COG0849	cell division
VA249_RS02100	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
VA249_RS02105	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
VA249_RS02120	COG0494	nUDIX hydrolase
VA249_RS02130	COG0505	Belongs to the CarA family
VA249_RS02135	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
VA249_RS02140	COG0730	response to heat
VA249_RS02145	COG0583	DNA-binding transcription factor activity
VA249_RS02150	COG2860	membrane
VA249_RS02175	COG0493	'glutamate synthase
VA249_RS02180	COG0070	glutamate synthase
VA249_RS02180	COG0069	glutamate synthase activity
VA249_RS02180	COG0067	glutamate synthase
VA249_RS02190	COG0070	glutamate synthase
VA249_RS02190	COG0069	glutamate synthase activity
VA249_RS02190	COG0067	glutamate synthase
VA249_RS02195	COG1242	4 iron, 4 sulfur cluster binding
VA249_RS02200	COG0784	Response regulator, receiver
VA249_RS02200	COG2198	Histidine kinase
VA249_RS02200	COG5002	protein histidine kinase activity
VA249_RS02210	COG0745	RESPONSE REGULATOR receiver
VA249_RS02220	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VA249_RS02235	COG0083	homoserine kinase activity
VA249_RS02240	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
VA249_RS02255	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
VA249_RS02270	COG1115	amino acid carrier protein
VA249_RS02300	COG3022	response to hydroperoxide
VA249_RS02305	COG0513	Belongs to the DEAD box helicase family
VA249_RS02320	COG0716	FMN binding
VA249_RS02325	COG4974	Belongs to the 'phage' integrase family
VA249_RS02330	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VA249_RS02345	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
VA249_RS02360	COG0667	Aldo Keto reductase
VA249_RS02370	COG3066	DNA modification
VA249_RS02380	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
VA249_RS02385	COG0730	response to heat
VA249_RS02400	COG1283	sodium-dependent phosphate transmembrane transporter activity
VA249_RS02405	COG0583	DNA-binding transcription factor activity
VA249_RS02410	COG0640	Transcriptional regulator
VA249_RS02415	COG0268	Binds directly to 16S ribosomal RNA
VA249_RS02420	COG0728	peptidoglycan biosynthetic process
VA249_RS02425	COG0196	riboflavin kinase activity
VA249_RS02440	COG1047	Peptidyl-prolyl cis-trans
VA249_RS02445	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
VA249_RS02450	COG3279	Response regulator of the LytR AlgR family
VA249_RS02455	COG3275	phosphorelay sensor kinase activity
VA249_RS02460	COG1966	Carbon starvation protein
VA249_RS02480	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
VA249_RS02490	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VA249_RS02495	COG1605	Chorismate mutase
VA249_RS02495	COG0287	Prephenate dehydrogenase
VA249_RS02500	COG0739	heme binding
VA249_RS02510	COG0488	(ABC) transporter
VA249_RS02525	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
VA249_RS02530	COG0077	Prephenate dehydratase
VA249_RS02530	COG1605	Chorismate mutase
VA249_RS02535	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VA249_RS02540	COG0741	lytic transglycosylase activity
VA249_RS02545	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VA249_RS02550	COG0564	pseudouridine synthase activity
VA249_RS02555	COG1496	oxidoreductase activity
VA249_RS02560	COG0542	response to heat
VA249_RS02655	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VA249_RS02660	COG0826	peptidase U32
VA249_RS02665	COG2974	May be involved in recombination
VA249_RS02670	COG0745	RESPONSE REGULATOR receiver
VA249_RS02675	COG5002	protein histidine kinase activity
VA249_RS02690	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
VA249_RS02695	COG0573	inorganic phosphate transmembrane transporter activity
VA249_RS02700	COG0581	inorganic phosphate transmembrane transporter activity
VA249_RS02705	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VA249_RS02710	COG0704	Plays a role in the regulation of phosphate uptake
VA249_RS02735	COG0450	alkyl hydroperoxide reductase
VA249_RS02740	COG0583	DNA-binding transcription factor activity
VA249_RS02745	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
VA249_RS02755	COG0517	IMP dehydrogenase activity
VA249_RS02765	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
VA249_RS02770	COG0343	queuine tRNA-ribosyltransferase activity
VA249_RS02775	COG1862	Preprotein translocase
VA249_RS02780	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VA249_RS02785	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VA249_RS02790	COG0483	inositol monophosphate 1-phosphatase activity
VA249_RS02795	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
VA249_RS02810	COG0822	iron-sulfur transferase activity
VA249_RS02815	COG0316	Belongs to the HesB IscA family
VA249_RS02830	COG0633	Ferredoxin
VA249_RS02835	COG2975	iron-sulfur cluster assembly
VA249_RS02865	COG0124	histidyl-tRNA synthetase
VA249_RS02870	COG2976	Protein conserved in bacteria
VA249_RS02875	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VA249_RS02900	COG0516	GMP reductase activity
VA249_RS02900	COG0517	IMP dehydrogenase activity
VA249_RS02910	COG1584	GPR1 FUN34 yaaH family protein
VA249_RS02915	COG1115	amino acid carrier protein
VA249_RS02920	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VA249_RS02925	COG0583	DNA-binding transcription factor activity
VA249_RS02930	COG2873	o-acetylhomoserine
VA249_RS02935	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
VA249_RS02995	COG2867	negative regulation of translational initiation
VA249_RS03000	COG2914	Belongs to the UPF0125 (RnfH) family
VA249_RS03005	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VA249_RS03010	COG0497	DNA recombination
VA249_RS03020	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
VA249_RS03025	COG1301	dicarboxylic acid transport
VA249_RS03035	COG0484	heat shock protein binding
VA249_RS03065	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
VA249_RS03070	COG0590	tRNA wobble adenosine to inosine editing
VA249_RS03080	COG0047	phosphoribosylformylglycinamidine synthase activity
VA249_RS03080	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
VA249_RS03100	COG2195	Cleaves the N-terminal amino acid of tripeptides
VA249_RS03105	COG2252	PERMEase
VA249_RS03110	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
VA249_RS03115	COG1073	alpha beta
VA249_RS03130	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
VA249_RS03135	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
VA249_RS03140	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VA249_RS03140	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VA249_RS03165	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
VA249_RS03170	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
VA249_RS03180	COG0142	geranyltranstransferase activity
VA249_RS03190	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
VA249_RS03200	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VA249_RS03200	COG0301	tRNA thio-modification
VA249_RS03205	COG0583	DNA-binding transcription factor activity
VA249_RS03215	COG2363	Small membrane protein
VA249_RS03225	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VA249_RS03230	COG1611	Belongs to the LOG family
VA249_RS03255	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
VA249_RS03260	COG1464	Belongs to the NlpA lipoprotein family
VA249_RS03265	COG2011	ABC-type metal ion transport system permease component
VA249_RS03270	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
VA249_RS03275	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VA249_RS03285	COG1263	PTS System
VA249_RS03285	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VA249_RS03290	COG0366	Alpha amylase catalytic
VA249_RS03295	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
VA249_RS03300	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VA249_RS03320	COG1686	Belongs to the peptidase S11 family
VA249_RS03325	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
VA249_RS03330	COG0772	Belongs to the SEDS family
VA249_RS03335	COG0768	penicillin binding
VA249_RS03340	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
VA249_RS03345	COG0799	negative regulation of ribosome biogenesis
VA249_RS03350	COG1466	dna polymerase III delta subunit
VA249_RS03355	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
VA249_RS03360	COG0495	leucyl-tRNA aminoacylation
VA249_RS03365	COG2888	peptidyl-tyrosine sulfation
VA249_RS03370	COG0815	Transfers the fatty acyl group on membrane lipoproteins
VA249_RS03375	COG4535	Mg2 and Co2 transporter CorC
VA249_RS03385	COG1702	phosphate starvation-inducible protein PhoH
VA249_RS03390	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VA249_RS03395	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VA249_RS03510	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
VA249_RS03530	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
VA249_RS03535	COG2890	protein-(glutamine-N5) methyltransferase activity
VA249_RS03540	COG3094	Invasion gene expression up-regulator, SirB
VA249_RS03545	COG2912	Transglutaminase-like superfamily
VA249_RS03555	COG0737	Belongs to the 5'-nucleotidase family
VA249_RS03560	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
VA249_RS03565	COG1187	pseudouridine synthase activity
VA249_RS03570	COG2840	Smr protein MutS2
VA249_RS03615	COG2608	mercury ion transmembrane transporter activity
VA249_RS03615	COG2217	Heavy metal translocating P-type atpase
VA249_RS03620	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VA249_RS03670	COG0784	Response regulator, receiver
VA249_RS03670	COG0835	chemotaxis
VA249_RS03675	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
VA249_RS03680	COG1815	bacterial-type flagellum-dependent cell motility
VA249_RS03685	COG1558	bacterial-type flagellum-dependent cell motility
VA249_RS03700	COG4787	bacterial-type flagellum-dependent cell motility
VA249_RS03710	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
VA249_RS03715	COG1706	bacterial-type flagellum-dependent cell motility
VA249_RS03720	COG1705	Flagellar rod assembly protein muramidase FlgJ
VA249_RS03720	COG3951	Flagellar rod assembly protein muramidase FlgJ
VA249_RS03735	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VA249_RS03740	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VA249_RS03745	COG2190	(PTS) system
VA249_RS03750	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
VA249_RS03755	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VA249_RS03760	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
VA249_RS03765	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
VA249_RS03795	COG1585	Membrane protein implicated in regulation of membrane protease activity
VA249_RS03800	COG0330	HflC and HflK could
VA249_RS03805	COG3118	belongs to the thioredoxin family
VA249_RS03810	COG0300	oxidoreductase activity
VA249_RS03815	COG1090	epimerase
VA249_RS03820	COG0622	Phosphoesterase
VA249_RS03840	COG3710	Transcriptional regulator
VA249_RS03845	COG0326	Molecular chaperone. Has ATPase activity
VA249_RS03855	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
VA249_RS03860	COG3104	oligopeptide transport
VA249_RS03870	COG0367	asparagine synthase
VA249_RS03875	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VA249_RS03875	COG4651	solute:proton antiporter activity
VA249_RS03880	COG1846	Transcriptional regulator
VA249_RS03880	COG1940	carbohydrate kinase activity
VA249_RS03885	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
VA249_RS03890	COG1263	PTS System
VA249_RS03890	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VA249_RS03890	COG2190	(PTS) system
VA249_RS03900	COG0735	belongs to the Fur family
VA249_RS03910	COG0716	FMN binding
VA249_RS03920	COG0596	Alpha beta hydrolase
VA249_RS03925	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
VA249_RS03930	COG0033	Phosphoglucomutase
VA249_RS03940	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
VA249_RS03955	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
VA249_RS03960	COG1053	succinate dehydrogenase
VA249_RS03965	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
VA249_RS03970	COG0567	Dehydrogenase, E1 component
VA249_RS03975	COG0508	dehydrogenase complex catalyzes the overall conversion of
VA249_RS03990	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VA249_RS03995	COG1121	(ABC) transporter
VA249_RS04000	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
VA249_RS04005	COG4977	sequence-specific DNA binding
VA249_RS04010	COG1918	ferrous iron import across plasma membrane
VA249_RS04035	COG3102	Protein conserved in bacteria
VA249_RS04040	COG0788	formyltetrahydrofolate deformylase activity
VA249_RS04045	COG1199	ATP-dependent helicase activity
VA249_RS04050	COG1214	PFAM Peptidase M22, glycoprotease
VA249_RS04065	COG0596	Alpha beta hydrolase
VA249_RS04070	COG0318	PFAM AMP-dependent synthetase and ligase
VA249_RS04075	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
VA249_RS04080	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
VA249_RS04085	COG2894	cell division
VA249_RS04100	COG2951	lytic endotransglycosylase activity
VA249_RS04110	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VA249_RS04125	COG1253	flavin adenine dinucleotide binding
VA249_RS04130	COG0513	Belongs to the DEAD box helicase family
VA249_RS04135	COG0569	domain protein
VA249_RS04140	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VA249_RS04170	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
VA249_RS04175	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
VA249_RS04180	COG0776	regulation of translation
VA249_RS04185	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VA249_RS04190	COG1555	photosystem II stabilization
VA249_RS04210	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
VA249_RS04215	COG0436	Aminotransferase
VA249_RS04220	COG1169	isochorismate synthase
VA249_RS04230	COG0596	Alpha beta hydrolase
VA249_RS04235	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
VA249_RS04255	COG2855	membrane
VA249_RS04260	COG0477	Major facilitator Superfamily
VA249_RS04305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VA249_RS04310	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VA249_RS04330	COG2226	methyltransferase
VA249_RS04340	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VA249_RS04345	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VA249_RS04355	COG3139	Protein of unknown function (DUF1315)
VA249_RS04360	COG0252	asparaginase activity
VA249_RS04365	COG0616	signal peptide processing
VA249_RS04370	COG0446	pyridine nucleotide-disulphide oxidoreductase
VA249_RS04370	COG1902	pentaerythritol trinitrate reductase activity
VA249_RS04375	COG0778	Nitroreductase
VA249_RS04380	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VA249_RS04395	COG2721	sulfolactate sulfo-lyase activity
VA249_RS04405	COG4948	Mandelate Racemase Muconate Lactonizing
VA249_RS04410	COG0123	including yeast histone deacetylase and acetoin utilization protein
VA249_RS04420	COG3083	sulfuric ester hydrolase activity
VA249_RS04445	COG1757	Na H antiporter
VA249_RS04450	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VA249_RS04455	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VA249_RS04460	COG2095	MarC family integral membrane protein
VA249_RS04465	COG1454	alcohol dehydrogenase
VA249_RS04465	COG1012	belongs to the aldehyde dehydrogenase family
VA249_RS04485	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
VA249_RS04490	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
VA249_RS04500	COG1132	(ABC) transporter
VA249_RS04520	COG2056	Na+-H+ antiporter family
VA249_RS04530	COG2885	chlorophyll binding
VA249_RS04540	COG0346	lactoylglutathione lyase activity
VA249_RS04545	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
VA249_RS04550	COG4660	Part of a membrane complex involved in electron transport
VA249_RS04555	COG4659	FMN binding
VA249_RS04560	COG4658	electron transport chain
VA249_RS04565	COG4656	Part of a membrane complex involved in electron transport
VA249_RS04575	COG4657	Part of a membrane complex involved in electron transport
VA249_RS04580	COG1882	Formate acetyltransferase
VA249_RS04590	COG0556	nucleotide-excision repair
VA249_RS04600	COG2198	Histidine kinase
VA249_RS04605	COG0391	Required for morphogenesis under gluconeogenic growth conditions
VA249_RS04610	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
VA249_RS04615	COG0521	Mo-molybdopterin cofactor biosynthetic process
VA249_RS04625	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
VA249_RS04630	COG0314	molybdopterin synthase activity
VA249_RS04640	COG0601	transmembrane transport
VA249_RS04645	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VA249_RS04650	COG0444	Belongs to the ABC transporter superfamily
VA249_RS04670	COG0435	Glutathione S-transferase
VA249_RS04675	COG3174	membrane
VA249_RS04680	COG0280	phosphate acetyltransferase
VA249_RS04680	COG0857	belongs to the CobB CobQ family
VA249_RS04700	COG4120	Belongs to the binding-protein-dependent transport system permease family
VA249_RS04705	COG1122	ATPase activity
VA249_RS04715	COG3706	GGDEF domain
VA249_RS04720	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VA249_RS04725	COG3012	SEC-C Motif Domain Protein
VA249_RS04725	COG3318	Belongs to the UPF0149 family
VA249_RS04730	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
VA249_RS04740	COG2186	Transcriptional regulator
VA249_RS04760	COG0572	uridine kinase
VA249_RS04765	COG2982	Protein involved in outer membrane biogenesis
VA249_RS04770	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
VA249_RS04775	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VA249_RS04780	COG0659	secondary active sulfate transmembrane transporter activity
VA249_RS04785	COG1530	ribonuclease E activity
VA249_RS04790	COG0564	pseudouridine synthase activity
VA249_RS04795	COG0424	maF-like protein
VA249_RS04800	COG1399	metal-binding, possibly nucleic acid-binding protein
VA249_RS04805	COG0333	Belongs to the bacterial ribosomal protein bL32 family
VA249_RS04815	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VA249_RS04845	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
VA249_RS04865	COG1263	PTS System
VA249_RS04865	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VA249_RS04885	COG4667	esterase of the alpha-beta hydrolase superfamily
VA249_RS04890	COG0469	pyruvate kinase activity
VA249_RS04895	COG1940	carbohydrate kinase activity
VA249_RS04900	COG0784	Response regulator, receiver
VA249_RS04900	COG0835	chemotaxis
VA249_RS04920	COG1028	Short-chain dehydrogenase reductase Sdr
VA249_RS04925	COG0616	signal peptide processing
VA249_RS04930	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
VA249_RS04935	COG0539	negative regulation of cytoplasmic translation
VA249_RS04945	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
VA249_RS04950	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
VA249_RS04960	COG4166	transmembrane transport
VA249_RS04980	COG3009	Protein conserved in bacteria
VA249_RS04985	COG3008	intermembrane lipid transfer
VA249_RS04985	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VA249_RS04990	COG2995	paraquat-inducible protein a
VA249_RS04995	COG1609	Transcriptional regulator
VA249_RS05000	COG3250	beta-galactosidase activity
VA249_RS05010	COG4580	involved in the transport of maltose and maltodextrins
VA249_RS05020	COG2211	Major facilitator Superfamily
VA249_RS05035	COG4232	protein-disulfide reductase activity
VA249_RS05040	COG3118	belongs to the thioredoxin family
VA249_RS05110	COG5002	protein histidine kinase activity
VA249_RS05110	COG3850	Histidine kinase
VA249_RS05115	COG0745	RESPONSE REGULATOR receiver
VA249_RS05120	COG0463	Glycosyl transferase, family 2
VA249_RS05125	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
VA249_RS05135	COG0840	transmembrane signaling receptor activity
VA249_RS05140	COG2964	Protein conserved in bacteria
VA249_RS05155	COG0446	pyridine nucleotide-disulphide oxidoreductase
VA249_RS05160	COG1032	radical SAM domain protein
VA249_RS05165	COG2203	Gaf domain
VA249_RS05165	COG5001	Diguanylate cyclase
VA249_RS05165	COG4251	negative regulation of phosphorylation
VA249_RS05165	COG3706	GGDEF domain
VA249_RS05180	COG0583	DNA-binding transcription factor activity
VA249_RS05185	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
VA249_RS05195	COG2350	Protein conserved in bacteria
VA249_RS05200	COG1607	acyl-coa hydrolase
VA249_RS05215	COG0159	tryptophan synthase activity
VA249_RS05225	COG0135	phosphoribosylanthranilate isomerase activity
VA249_RS05225	COG0134	indole-3-glycerol-phosphate synthase activity
VA249_RS05235	COG0512	Glutamine amidotransferase of anthranilate synthase
VA249_RS05240	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VA249_RS05250	COG0613	PHP domain protein
VA249_RS05255	COG0009	L-threonylcarbamoyladenylate synthase
VA249_RS05260	COG1187	pseudouridine synthase activity
VA249_RS05280	COG0417	DNA replication proofreading
VA249_RS05285	COG2197	response regulator
VA249_RS05290	COG0322	excinuclease ABC activity
VA249_RS05330	COG0019	diaminopimelate decarboxylase activity
VA249_RS05335	COG0287	Prephenate dehydrogenase
VA249_RS05355	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VA249_RS05360	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VA249_RS05365	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VA249_RS05390	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VA249_RS05395	COG2989	Protein conserved in bacteria
VA249_RS05400	COG3108	Peptidase M15
VA249_RS05405	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VA249_RS05420	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
VA249_RS05450	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VA249_RS05475	COG1448	Aminotransferase
VA249_RS05490	COG0017	Asparaginyl-tRNA synthetase
VA249_RS05495	COG0720	synthase
VA249_RS05505	COG1760	l-serine dehydratase
VA249_RS05510	COG0814	amino acid
VA249_RS05515	COG0494	nUDIX hydrolase
VA249_RS05525	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VA249_RS05540	COG3106	COG3106 Predicted ATPase
VA249_RS05555	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VA249_RS06010	COG0494	nUDIX hydrolase
VA249_RS06235	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
VA249_RS06240	COG2944	sequence-specific DNA binding
VA249_RS06260	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VA249_RS06320	COG0494	nUDIX hydrolase
VA249_RS06470	COG0456	acetyltransferase
VA249_RS06480	COG0471	metal ion transport
VA249_RS06485	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VA249_RS06485	COG4191	Histidine kinase
VA249_RS06495	COG5001	Diguanylate cyclase
VA249_RS06505	COG1280	lysine exporter protein (LysE YggA)
VA249_RS06510	COG1328	CTP reductase activity
VA249_RS06515	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VA249_RS06525	COG0861	Integral membrane protein TerC family
VA249_RS06540	COG0814	amino acid
VA249_RS06545	COG3437	response regulator, receiver
VA249_RS06560	COG1132	(ABC) transporter
VA249_RS06565	COG1132	(ABC) transporter
VA249_RS06580	COG0443	Heat shock 70 kDa protein
VA249_RS06585	COG0443	Heat shock 70 kDa protein
VA249_RS06595	COG3706	GGDEF domain
VA249_RS06605	COG0776	regulation of translation
VA249_RS06625	COG0295	cytidine deaminase activity
VA249_RS06630	COG1346	cytolysis
VA249_RS06640	COG2925	Exonuclease
VA249_RS06645	COG0702	epimerase
VA249_RS06655	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
VA249_RS06680	COG4139	cobalamin transport
VA249_RS06690	COG3063	Type IV pilus biogenesis stability protein PilW
VA249_RS06710	COG0531	amino acid
VA249_RS06715	COG1280	lysine exporter protein (LysE YggA)
VA249_RS06720	COG1560	Kdo2-lipid A biosynthetic process
VA249_RS06725	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
VA249_RS06730	COG1280	lysine exporter protein (LysE YggA)
VA249_RS06735	COG1115	amino acid carrier protein
VA249_RS06770	COG0583	DNA-binding transcription factor activity
VA249_RS06780	COG1451	nucleotide metabolic process
VA249_RS06790	COG2205	protein histidine kinase activity
VA249_RS06790	COG0784	Response regulator, receiver
VA249_RS06815	COG3938	Belongs to the proline racemase family
VA249_RS06830	COG2423	ornithine cyclodeaminase activity
VA249_RS06835	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VA249_RS06840	COG3842	ATPase activity
VA249_RS06845	COG1176	ABC-type spermidine putrescine transport system, permease component I
VA249_RS06850	COG1177	transmembrane transport
VA249_RS06905	COG0583	DNA-binding transcription factor activity
VA249_RS06945	COG2195	Cleaves the N-terminal amino acid of tripeptides
VA249_RS07000	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
VA249_RS07010	COG0625	glutathione transferase activity
VA249_RS07075	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VA249_RS07085	COG0438	transferase activity, transferring glycosyl groups
VA249_RS07100	COG0110	maltose O-acetyltransferase activity
VA249_RS07160	COG0784	Response regulator, receiver
VA249_RS07160	COG2205	protein histidine kinase activity
VA249_RS07175	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
VA249_RS07180	COG0668	transmembrane transport
VA249_RS07185	COG3247	response to pH
VA249_RS07190	COG0697	spore germination
VA249_RS07205	COG0110	maltose O-acetyltransferase activity
VA249_RS07210	COG3064	Membrane
VA249_RS07230	COG0534	Mate efflux family protein
VA249_RS07235	COG0307	riboflavin synthase, alpha
VA249_RS07245	COG3001	Fructosamine kinase
VA249_RS07250	COG2201	protein-glutamate methylesterase activity
VA249_RS07255	COG3706	GGDEF domain
VA249_RS07265	COG0791	NLP P60 protein
VA249_RS07280	COG3148	PFAM DTW domain containing protein
VA249_RS07285	COG1940	carbohydrate kinase activity
VA249_RS07295	COG0303	'Molybdopterin
VA249_RS07300	COG0746	molybdenum cofactor guanylyltransferase activity
VA249_RS07305	COG3842	ATPase activity
VA249_RS07325	COG4191	Histidine kinase
VA249_RS07345	COG0488	(ABC) transporter
VA249_RS07350	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
VA249_RS07370	COG3381	protein complex oligomerization
VA249_RS07380	COG0243	molybdopterin cofactor binding
VA249_RS07380	COG3383	formate dehydrogenase (NAD+) activity
VA249_RS07385	COG0437	4 iron, 4 sulfur cluster binding
VA249_RS07400	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
VA249_RS07405	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VA249_RS07415	COG1177	transmembrane transport
VA249_RS07425	COG3842	ATPase activity
VA249_RS07450	COG0589	response to stress
VA249_RS07455	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VA249_RS07470	COG2217	Heavy metal translocating P-type atpase
VA249_RS07480	COG2010	Cytochrome c
VA249_RS07495	COG3278	Belongs to the heme-copper respiratory oxidase family
VA249_RS07510	COG2205	protein histidine kinase activity
VA249_RS07510	COG0784	Response regulator, receiver
VA249_RS07525	COG3120	sequence-specific DNA binding
VA249_RS07530	COG1067	ATP-dependent peptidase activity
VA249_RS07535	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VA249_RS07550	COG0488	(ABC) transporter
VA249_RS07570	COG0167	dihydroorotate dehydrogenase activity
VA249_RS07575	COG2902	Dehydrogenase
VA249_RS07585	COG0308	aminopeptidase N
VA249_RS07600	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
VA249_RS07605	COG1956	GAF domain-containing protein
VA249_RS07610	COG1132	(ABC) transporter
VA249_RS07615	COG2995	paraquat-inducible protein a
VA249_RS07620	COG3008	intermembrane lipid transfer
VA249_RS07645	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VA249_RS07660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VA249_RS07665	COG4597	amino acid ABC transporter
VA249_RS07670	COG0765	amino acid transport
VA249_RS07675	COG1126	abc transporter atp-binding protein
VA249_RS07680	COG0670	Belongs to the BI1 family
VA249_RS07685	COG2920	part of a sulfur-relay system
VA249_RS07690	COG1254	Belongs to the acylphosphatase family
VA249_RS07735	COG0602	queuosine metabolic process
VA249_RS07740	COG0561	phosphatase activity
VA249_RS07760	COG2828	Protein conserved in bacteria
VA249_RS07770	COG0372	Belongs to the citrate synthase family
VA249_RS07775	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
VA249_RS07780	COG2186	Transcriptional regulator
VA249_RS07795	COG0730	response to heat
VA249_RS07800	COG2358	TRAP transporter, solute receptor (TAXI family
VA249_RS07805	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VA249_RS07815	COG1012	belongs to the aldehyde dehydrogenase family
VA249_RS07820	COG3284	Transcriptional regulator
VA249_RS07855	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
VA249_RS07860	COG0363	glucosamine-6-phosphate deaminase activity
VA249_RS07865	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
VA249_RS07880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VA249_RS07895	COG0702	epimerase
VA249_RS07900	COG0583	DNA-binding transcription factor activity
VA249_RS07910	COG0527	aspartate kinase activity
VA249_RS07915	COG0662	Cupin 2, conserved barrel domain protein
VA249_RS07920	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
VA249_RS07925	COG0456	acetyltransferase
VA249_RS07930	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VA249_RS07950	COG4176	ABC-type proline glycine betaine transport system permease component
VA249_RS07955	COG2113	Glycine betaine
VA249_RS07960	COG0534	Mate efflux family protein
VA249_RS07970	COG1643	Atp-dependent helicase
VA249_RS07975	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
VA249_RS08005	COG0072	phenylalanine-tRNA ligase activity
VA249_RS08005	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VA249_RS08020	COG0393	Putative heavy-metal-binding
VA249_RS08030	COG0291	Belongs to the bacterial ribosomal protein bL35 family
VA249_RS08040	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
VA249_RS08055	COG3064	Membrane
VA249_RS08060	COG2199	diguanylate cyclase activity
VA249_RS08060	COG2200	EAL domain
VA249_RS08060	COG3287	FIST C domain
VA249_RS08125	COG3706	GGDEF domain
VA249_RS08130	COG1960	acyl-CoA dehydrogenase activity
VA249_RS08155	COG0010	Belongs to the arginase family
VA249_RS08160	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
VA249_RS08165	COG2986	histidine ammonia-lyase
VA249_RS08180	COG0247	lactate metabolic process
VA249_RS08180	COG0277	FAD linked oxidase domain protein
VA249_RS08215	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
VA249_RS08225	COG1643	Atp-dependent helicase
VA249_RS08235	COG2949	membrane
VA249_RS08240	COG0471	metal ion transport
VA249_RS08245	COG3706	GGDEF domain
VA249_RS08265	COG0492	ferredoxin-NADP+ reductase activity
VA249_RS08270	COG4988	ABC transporter
VA249_RS08275	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
VA249_RS08285	COG3706	GGDEF domain
VA249_RS08295	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
VA249_RS08305	COG4191	Histidine kinase
VA249_RS08305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VA249_RS08320	COG3070	regulator of competence-specific genes
VA249_RS08330	COG2431	L-lysine efflux transmembrane transporter activity
VA249_RS08340	COG0076	glutamate decarboxylase activity
VA249_RS08345	COG1737	Transcriptional regulator
VA249_RS08355	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VA249_RS08370	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VA249_RS08400	COG4181	ATPase activity
VA249_RS08405	COG0534	Mate efflux family protein
VA249_RS08410	COG0702	epimerase
VA249_RS08415	COG1609	Transcriptional regulator
VA249_RS08425	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VA249_RS08435	COG2814	Major facilitator Superfamily
VA249_RS08440	COG1187	pseudouridine synthase activity
VA249_RS08445	COG1061	Type III restriction enzyme res subunit
VA249_RS08470	COG0737	Belongs to the 5'-nucleotidase family
VA249_RS08480	COG3313	Fe-S protein
VA249_RS08505	COG0493	'glutamate synthase
VA249_RS08515	COG0398	Pfam SNARE associated Golgi protein
VA249_RS08520	COG4134	Bacterial extracellular solute-binding protein
VA249_RS08525	COG4135	transport system, permease component
VA249_RS08530	COG4136	ATPase activity
VA249_RS08535	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
VA249_RS08545	COG3604	Transcriptional regulator
VA249_RS08550	COG1151	hydroxylamine reductase activity
VA249_RS08565	COG0564	pseudouridine synthase activity
VA249_RS08575	COG0733	neurotransmitter:sodium symporter activity
VA249_RS08585	COG0626	cystathionine gamma-synthase activity
VA249_RS08590	COG2818	Glycosylase
VA249_RS08600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VA249_RS08625	COG1842	Phage shock protein A
VA249_RS08630	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
VA249_RS08640	COG4168	peptide transport system, permease
VA249_RS08645	COG4171	peptide transport system, permease
VA249_RS08655	COG4172	Belongs to the ABC transporter superfamily
VA249_RS08665	COG1227	inorganic diphosphatase activity
VA249_RS08680	COG0243	molybdopterin cofactor binding
VA249_RS08685	COG3005	denitrification pathway
VA249_RS08690	COG4459	periplasmic nitrate reductase
VA249_RS08695	COG0390	transport system, permease component
VA249_RS08705	COG2116	formate transmembrane transporter activity
VA249_RS08730	COG1434	Gram-negative-bacterium-type cell wall biogenesis
VA249_RS08735	COG1435	thymidine kinase activity
VA249_RS08740	COG0215	cysteine-tRNA ligase activity
VA249_RS08745	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VA249_RS08750	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VA249_RS08755	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VA249_RS08760	COG3012	SEC-C Motif Domain Protein
VA249_RS08765	COG0140	phosphoribosyl-ATP diphosphatase activity
VA249_RS08765	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
VA249_RS08775	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
VA249_RS08780	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
VA249_RS08785	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VA249_RS08785	COG0131	Imidazoleglycerol-phosphate dehydratase
VA249_RS08790	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VA249_RS08795	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
VA249_RS08810	COG1757	Na H antiporter
VA249_RS08815	COG2916	Histone family protein nucleoid-structuring protein H-NS
VA249_RS08820	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VA249_RS08830	COG0482	sulfurtransferase activity
VA249_RS08840	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
VA249_RS08850	COG2268	Band 7 protein
VA249_RS08860	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
VA249_RS08875	COG0300	oxidoreductase activity
VA249_RS08895	COG3344	reverse transcriptase
VA249_RS08910	COG0156	8-amino-7-oxononanoate synthase activity
VA249_RS08925	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
VA249_RS08940	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
VA249_RS08945	COG1674	ftsk spoiiie
VA249_RS08955	COG0686	Belongs to the AlaDH PNT family
VA249_RS08965	COG0583	DNA-binding transcription factor activity
VA249_RS08980	COG2084	Dehydrogenase
VA249_RS09000	COG0800	Aldolase
VA249_RS09005	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VA249_RS09010	COG1917	Cupin 2, conserved barrel domain protein
VA249_RS09025	COG2731	YhcH YjgK YiaL family protein
VA249_RS09030	COG0534	Mate efflux family protein
VA249_RS09035	COG2186	Transcriptional regulator
VA249_RS09040	COG2186	Transcriptional regulator
VA249_RS09045	COG0517	IMP dehydrogenase activity
VA249_RS09050	COG2176	DNA-directed DNA polymerase activity
VA249_RS09070	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VA249_RS09095	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VA249_RS09100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VA249_RS09110	COG2824	Alkylphosphonate utilization operon protein PhnA
VA249_RS09140	COG0514	ATP-dependent DNA helicase (RecQ)
VA249_RS09160	COG0514	ATP-dependent DNA helicase (RecQ)
VA249_RS09165	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
VA249_RS09170	COG0302	gtp cyclohydrolase
VA249_RS09175	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
VA249_RS09180	COG0602	queuosine metabolic process
VA249_RS09250	COG1397	ADP-ribosylglycohydrolase
VA249_RS09260	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
VA249_RS09330	COG0582	viral genome integration into host DNA
VA249_RS09345	COG0784	Response regulator, receiver
VA249_RS09345	COG5002	protein histidine kinase activity
VA249_RS09365	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
VA249_RS09370	COG2885	chlorophyll binding
VA249_RS09375	COG0823	Involved in the tonB-independent uptake of proteins
VA249_RS09390	COG0811	peptide transport
VA249_RS09395	COG0824	Thioesterase
VA249_RS09405	COG4890	Cyd operon protein YbgT
VA249_RS09410	COG1294	oxidase, subunit
VA249_RS09415	COG1271	oxidase subunit
VA249_RS09425	COG0632	four-way junction helicase activity
VA249_RS09430	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
VA249_RS09435	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
VA249_RS09440	COG1801	Protein of unknown function DUF72
VA249_RS09445	COG4106	trans-aconitate 2-methyltransferase activity
VA249_RS09450	COG0500	methyltransferase
VA249_RS09455	COG0189	ligase activity
VA249_RS09455	COG4067	protein conserved in archaea
VA249_RS09475	COG1609	Transcriptional regulator
VA249_RS09515	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
VA249_RS09520	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
VA249_RS09525	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
VA249_RS09530	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VA249_RS09535	COG1434	Gram-negative-bacterium-type cell wall biogenesis
VA249_RS09540	COG0745	RESPONSE REGULATOR receiver
VA249_RS09545	COG3381	protein complex oligomerization
VA249_RS09555	COG3070	regulator of competence-specific genes
VA249_RS09575	COG0297	glycogen (starch) synthase activity
VA249_RS09580	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
VA249_RS09585	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VA249_RS09610	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
VA249_RS09615	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
VA249_RS09620	COG0542	response to heat
VA249_RS09630	COG1278	Cold shock
VA249_RS09640	COG1187	pseudouridine synthase activity
VA249_RS09645	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
VA249_RS09655	COG1199	ATP-dependent helicase activity
VA249_RS09660	COG0730	response to heat
VA249_RS09665	COG3923	Primosomal replication protein n
VA249_RS09675	COG0708	Exodeoxyribonuclease III
VA249_RS09710	COG1882	Formate acetyltransferase
VA249_RS09720	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VA249_RS09735	COG2766	serine protein kinase
VA249_RS09745	COG2719	SpoVR family
VA249_RS09765	COG1132	(ABC) transporter
VA249_RS09780	COG4591	ABC-type transport system involved in lipoprotein release permease component
VA249_RS09785	COG1136	(ABC) transporter
VA249_RS09790	COG4591	ABC-type transport system involved in lipoprotein release permease component
VA249_RS09800	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
VA249_RS09815	COG1252	NADH dehydrogenase
VA249_RS09825	COG0510	thiamine kinase activity
VA249_RS09845	COG0537	adenosine 5'-monophosphoramidase activity
VA249_RS09875	COG0516	GMP reductase activity
VA249_RS09875	COG0517	IMP dehydrogenase activity
VA249_RS09880	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
VA249_RS09885	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
VA249_RS09890	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VA249_RS09900	COG3706	GGDEF domain
VA249_RS09915	COG3126	Type III secretion system lipoprotein chaperone (YscW)
VA249_RS09920	COG1946	Acyl-CoA thioesterase
VA249_RS09925	COG1522	sequence-specific DNA binding
VA249_RS09945	COG0668	transmembrane transport
VA249_RS09950	COG0076	glutamate decarboxylase activity
VA249_RS09955	COG2985	domain, Protein
VA249_RS09960	COG2261	transglycosylase associated protein
VA249_RS09965	COG2983	Belongs to the UPF0260 family
VA249_RS09975	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
VA249_RS09980	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
VA249_RS09985	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
VA249_RS09990	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
VA249_RS10000	COG2832	Protein of unknown function (DUF454)
VA249_RS10005	COG0745	RESPONSE REGULATOR receiver
VA249_RS10010	COG0583	DNA-binding transcription factor activity
VA249_RS10015	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
VA249_RS10020	COG1286	toxin biosynthetic process
VA249_RS10025	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
VA249_RS10030	COG0285	dihydrofolate synthase activity
VA249_RS10050	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VA249_RS10055	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VA249_RS10060	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VA249_RS10080	COG3101	peptidyl-lysine hydroxylation
VA249_RS10085	COG2860	membrane
VA249_RS10090	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
VA249_RS10095	COG2890	protein-(glutamine-N5) methyltransferase activity
VA249_RS10100	COG2840	Smr protein MutS2
VA249_RS10105	COG2062	phosphohistidine phosphatase, SixA
VA249_RS10120	COG1024	Enoyl-CoA hydratase
VA249_RS10120	COG1250	3-hydroxyacyl-CoA dehydrogenase
VA249_RS10125	COG0183	Belongs to the thiolase family
VA249_RS10140	COG2067	long-chain fatty acid transport protein
VA249_RS10150	COG2853	Lipoprotein
VA249_RS10155	COG4235	cytochrome complex assembly
VA249_RS10155	COG3088	subunit of a heme lyase
VA249_RS10165	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VA249_RS10170	COG1138	Cytochrome C-type biogenesis protein
VA249_RS10185	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VA249_RS10190	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VA249_RS10195	COG4133	protoheme IX ABC transporter activity
VA249_RS10205	COG0835	chemotaxis
VA249_RS10215	COG1192	Involved in chromosome partitioning
VA249_RS10220	COG2201	protein-glutamate methylesterase activity
VA249_RS10225	COG2198	Histidine kinase
VA249_RS10225	COG0784	Response regulator, receiver
VA249_RS10225	COG0643	Histidine kinase
VA249_RS10230	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
VA249_RS10265	COG1684	flagellar biosynthetic protein fliR
VA249_RS10270	COG1987	bacterial-type flagellum assembly
VA249_RS10320	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
VA249_RS10330	COG1677	Flagellar hook-basal body complex protein FliE
VA249_RS10350	COG1516	flagellar protein fliS
VA249_RS10360	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
VA249_RS10365	COG1334	flagellar protein FlaG
VA249_RS10370	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VA249_RS10375	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VA249_RS10380	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VA249_RS10385	COG2837	iron assimilation
VA249_RS10410	COG1393	Belongs to the ArsC family
VA249_RS10430	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
VA249_RS10435	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VA249_RS10440	COG2716	regulation of RNA biosynthetic process
VA249_RS10470	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
VA249_RS10505	COG3344	reverse transcriptase
VA249_RS10530	COG4783	chaperone-mediated protein folding
VA249_RS10535	COG1393	Belongs to the ArsC family
VA249_RS10555	COG2233	PERMEase
VA249_RS10560	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
VA249_RS10565	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
VA249_RS10570	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
VA249_RS10575	COG0121	glutamine amidotransferase
VA249_RS10580	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VA249_RS10585	COG1960	acyl-CoA dehydrogenase activity
VA249_RS10600	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
VA249_RS10610	COG2226	methyltransferase
VA249_RS10615	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VA249_RS10620	COG0741	lytic transglycosylase activity
VA249_RS10620	COG1388	LysM domain
VA249_RS10635	COG0347	Belongs to the P(II) protein family
VA249_RS10655	COG0587	DNA-directed DNA polymerase activity
VA249_RS10680	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VA249_RS10685	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
VA249_RS10695	COG0750	zinc metalloprotease
VA249_RS10705	COG0575	Belongs to the CDS family
VA249_RS10710	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
VA249_RS10725	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
VA249_RS10735	COG0024	Methionine aminopeptidase
VA249_RS10750	COG0564	pseudouridine synthase activity
VA249_RS10755	COG3098	single-species biofilm formation
VA249_RS10780	COG1671	Belongs to the UPF0178 family
VA249_RS10785	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
VA249_RS10790	COG1720	tRNA m6t6A37 methyltransferase activity
VA249_RS10815	COG0733	neurotransmitter:sodium symporter activity
VA249_RS10825	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VA249_RS10830	COG0514	ATP-dependent DNA helicase (RecQ)
VA249_RS10835	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
VA249_RS10840	COG0840	transmembrane signaling receptor activity
VA249_RS10855	COG1477	protein flavinylation
VA249_RS10865	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VA249_RS10890	COG0271	Belongs to the BolA IbaG family
VA249_RS10895	COG2813	Specifically methylates the guanine in position
VA249_RS10920	COG1595	DNA-templated transcription, initiation
VA249_RS10940	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
VA249_RS10945	COG0693	protein deglycase activity
VA249_RS10950	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VA249_RS10955	COG2166	iron-sulfur cluster assembly
VA249_RS10960	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
VA249_RS10965	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
VA249_RS10975	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VA249_RS10975	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VA249_RS10985	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
VA249_RS10990	COG1074	ATP-dependent DNA helicase activity
VA249_RS10995	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
VA249_RS11010	COG3141	response to X-ray
VA249_RS11025	COG2171	N-acyltransferase activity
VA249_RS11030	COG1929	Belongs to the glycerate kinase type-1 family
VA249_RS11035	COG2084	Dehydrogenase
VA249_RS11040	COG3622	Belongs to the hyi family
VA249_RS11045	COG3960	tartronate-semialdehyde synthase activity
VA249_RS11060	COG1953	Uracil, thiamine, allantoin
VA249_RS11070	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VA249_RS11075	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
VA249_RS11085	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
VA249_RS11090	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
VA249_RS11095	COG0583	DNA-binding transcription factor activity
VA249_RS11100	COG0549	Belongs to the carbamate kinase family
VA249_RS11105	COG3257	ureidoglycine aminohydrolase activity
VA249_RS11110	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
VA249_RS11120	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
VA249_RS11125	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
VA249_RS11145	COG1609	Transcriptional regulator
VA249_RS11150	COG2017	converts alpha-aldose to the beta-anomer
VA249_RS11160	COG1085	galactose-1-phosphate uridylyltransferase
VA249_RS11165	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VA249_RS11170	COG1609	Transcriptional regulator
VA249_RS11175	COG0583	DNA-binding transcription factor activity
VA249_RS11185	COG1022	Amp-dependent synthetase and ligase
VA249_RS11190	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VA249_RS11195	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
VA249_RS11205	COG0560	Phosphoserine phosphatase
VA249_RS11215	COG0813	purine-nucleoside phosphorylase activity
VA249_RS11225	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
VA249_RS11235	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VA249_RS11240	COG0084	hydrolase, TatD family'
VA249_RS11250	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
VA249_RS11270	COG3153	acetyltransferase
VA249_RS11275	COG3154	lipid carrier protein
VA249_RS11285	COG0826	peptidase U32
VA249_RS11290	COG0826	peptidase U32
VA249_RS11295	COG0534	Mate efflux family protein
VA249_RS11300	COG1846	Transcriptional regulator
VA249_RS11310	COG1185	polyribonucleotide nucleotidyltransferase activity
VA249_RS11315	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
VA249_RS11335	COG0195	Participates in both transcription termination and antitermination
VA249_RS11340	COG0779	Required for maturation of 30S ribosomal subunits
VA249_RS11355	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VA249_RS11360	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VA249_RS11365	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
VA249_RS11370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VA249_RS11375	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
VA249_RS11380	COG1534	Rna-binding protein
VA249_RS11385	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VA249_RS11390	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VA249_RS11395	COG2027	D-alanyl-D-alanine carboxypeptidase
VA249_RS11405	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VA249_RS11410	COG0739	heme binding
VA249_RS11425	COG0316	Belongs to the HesB IscA family
VA249_RS11430	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
VA249_RS11435	COG0628	permease
VA249_RS11445	COG2205	protein histidine kinase activity
VA249_RS11445	COG0784	Response regulator, receiver
VA249_RS11450	COG0747	negative chemotaxis
VA249_RS11460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VA249_RS11465	COG0444	Belongs to the ABC transporter superfamily
VA249_RS11470	COG4608	Belongs to the ABC transporter superfamily
VA249_RS11480	COG2971	BadF BadG BcrA BcrD
VA249_RS11495	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VA249_RS11500	COG3842	ATPase activity
VA249_RS11510	COG1840	ABC-type Fe3 transport system, periplasmic component
VA249_RS11515	COG0004	ammonium transporteR
VA249_RS11530	COG3835	regulator
VA249_RS11535	COG2610	gluconate transmembrane transporter activity
VA249_RS11540	COG1929	Belongs to the glycerate kinase type-1 family
VA249_RS11545	COG1049	propionate catabolic process, 2-methylcitrate cycle
VA249_RS11550	COG1752	Esterase of the alpha-beta hydrolase superfamily
VA249_RS11555	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VA249_RS11560	COG1643	Atp-dependent helicase
VA249_RS11565	COG1489	DNA binding
VA249_RS11575	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VA249_RS11585	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VA249_RS11600	COG0842	Transport permease protein
VA249_RS11605	COG1131	(ABC) transporter
VA249_RS11610	COG0659	secondary active sulfate transmembrane transporter activity
VA249_RS11615	COG0288	reversible hydration of carbon dioxide
VA249_RS11630	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VA249_RS11635	COG0508	dehydrogenase complex catalyzes the overall conversion of
VA249_RS11640	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
VA249_RS11645	COG2186	Transcriptional regulator
VA249_RS11665	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VA249_RS11670	COG1459	type II secretion system
VA249_RS11680	COG0237	dephospho-CoA kinase activity
VA249_RS11685	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
VA249_RS11690	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
VA249_RS11715	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
VA249_RS11720	COG4137	Cytochrome C assembly protein
VA249_RS11725	COG4536	flavin adenine dinucleotide binding
VA249_RS11730	COG1854	S-ribosylhomocysteine lyase activity
VA249_RS11745	COG0612	Peptidase, M16
VA249_RS11750	COG1238	metal cluster binding
VA249_RS11760	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
VA249_RS11765	COG0511	ligase activity, forming carbon-carbon bonds
VA249_RS11765	COG5016	pyruvate
VA249_RS11770	COG3630	sodium ion export across plasma membrane
VA249_RS11860	COG0527	aspartate kinase activity
VA249_RS11875	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
VA249_RS11880	COG1546	Belongs to the CinA family
VA249_RS11890	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VA249_RS11915	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
VA249_RS11920	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
VA249_RS11930	COG0148	phosphopyruvate hydratase activity
VA249_RS11940	COG3956	TIGRFAM MazG family protein
VA249_RS11945	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VA249_RS11965	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
VA249_RS11970	COG1381	Involved in DNA repair and RecF pathway recombination
VA249_RS11975	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
VA249_RS11995	COG3086	response to oxidative stress
VA249_RS12010	COG1595	DNA-templated transcription, initiation
VA249_RS12015	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
VA249_RS12020	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
VA249_RS12040	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VA249_RS12045	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VA249_RS12050	COG3079	Belongs to the UPF0149 family
VA249_RS12055	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
VA249_RS12065	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
VA249_RS12075	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VA249_RS12085	COG0583	DNA-binding transcription factor activity
VA249_RS12100	COG0668	transmembrane transport
VA249_RS12105	COG0191	fructose-bisphosphate aldolase activity
VA249_RS12110	COG0126	phosphoglycerate kinase activity
VA249_RS12125	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VA249_RS12150	COG2356	endonuclease I
VA249_RS12155	COG1385	rRNA (uridine-N3-)-methyltransferase activity
VA249_RS12160	COG0189	ligase activity
VA249_RS12165	COG1678	Uncharacterized ACR, COG1678
VA249_RS12170	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
VA249_RS12185	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
VA249_RS12190	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
VA249_RS12195	COG0762	integral membrane protein
VA249_RS12210	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
VA249_RS12215	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VA249_RS12235	COG1194	a g-specific adenine glycosylase
VA249_RS12240	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
VA249_RS12285	COG0840	transmembrane signaling receptor activity
VA249_RS12355	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VA249_RS12355	COG3153	acetyltransferase
VA249_RS12380	COG0795	lipopolysaccharide-transporting ATPase activity
VA249_RS12385	COG0795	lipopolysaccharide-transporting ATPase activity
VA249_RS12390	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VA249_RS12395	COG2927	DNA polymerase III (CHI subunit)
VA249_RS12400	COG0525	valine-tRNA ligase activity
VA249_RS12410	COG0456	acetyltransferase
VA249_RS12450	COG0251	oxidation-reduction process
VA249_RS12455	COG0204	Acyl-transferase
VA249_RS12465	COG5007	Belongs to the BolA IbaG family
VA249_RS12475	COG2854	intermembrane phospholipid transfer
VA249_RS12480	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VA249_RS12485	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
VA249_RS12490	COG1127	ABC transporter
VA249_RS12500	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
VA249_RS12500	COG0517	IMP dehydrogenase activity
VA249_RS12510	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
VA249_RS12515	COG1137	ATPase activity
VA249_RS12525	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VA249_RS12530	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VA249_RS12540	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VA249_RS12545	COG2239	Acts as a magnesium transporter
VA249_RS12550	COG0312	modulator of DNA gyrase
VA249_RS12555	COG3028	Belongs to the UPF0307 family
VA249_RS12560	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VA249_RS12565	COG0564	pseudouridine synthase activity
VA249_RS12570	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
VA249_RS12575	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
VA249_RS12580	COG0312	modulator of DNA gyrase
VA249_RS12585	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VA249_RS12590	COG3164	Protein of unknown function
VA249_RS12600	COG0424	maF-like protein
VA249_RS12605	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
VA249_RS12610	COG1792	Involved in formation and maintenance of cell shape
VA249_RS12615	COG1077	Cell shape determining protein MreB Mrl
VA249_RS12650	COG2165	general secretion pathway protein
VA249_RS12660	COG1459	type II secretion system
VA249_RS12665	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VA249_RS12675	COG3267	Type II secretory pathway component ExeA
VA249_RS12675	COG3409	Peptidoglycan-binding domain 1 protein
VA249_RS12680	COG1450	Type ii and iii secretion system protein
VA249_RS12700	COG2200	EAL domain
VA249_RS12700	COG2199	diguanylate cyclase activity
VA249_RS12705	COG0629	single-stranded DNA binding
VA249_RS12710	COG2197	response regulator
VA249_RS12720	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
VA249_RS12730	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
VA249_RS12735	COG0527	aspartate kinase activity
VA249_RS12740	COG0646	methionine synthase
VA249_RS12740	COG1410	methionine synthase
VA249_RS12840	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VA249_RS12860	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VA249_RS12865	COG0735	belongs to the Fur family
VA249_RS12880	COG0432	Pfam Uncharacterised protein family UPF0047
VA249_RS12890	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VA249_RS12905	COG0359	binds to the 23S rRNA
VA249_RS12915	COG2965	DNA replication, synthesis of RNA primer
VA249_RS12920	COG0360	Binds together with S18 to 16S ribosomal RNA
VA249_RS12925	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
VA249_RS12930	COG0338	D12 class N6 adenine-specific DNA methyltransferase
VA249_RS12975	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
VA249_RS12985	COG0678	peroxiredoxin activity
VA249_RS12985	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VA249_RS12995	COG0165	Argininosuccinate lyase
VA249_RS12995	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VA249_RS13010	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
VA249_RS13020	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
VA249_RS13030	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
VA249_RS13035	COG0527	aspartate kinase activity
VA249_RS13035	COG0460	homoserine dehydrogenase
VA249_RS13040	COG0626	cystathionine gamma-synthase activity
VA249_RS13050	COG0281	malic enzyme
VA249_RS13060	COG2906	2 iron, 2 sulfur cluster binding
VA249_RS13070	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VA249_RS13085	COG2168	tRNA wobble position uridine thiolation
VA249_RS13090	COG2923	Belongs to the DsrF TusC family
VA249_RS13095	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
VA249_RS13100	COG2964	Protein conserved in bacteria
VA249_RS13105	COG0545	Peptidyl-prolyl cis-trans isomerase
VA249_RS13120	COG1446	asparaginase
VA249_RS13125	COG1047	Peptidyl-prolyl cis-trans
VA249_RS13140	COG2249	NAD(P)H dehydrogenase (quinone) activity
VA249_RS13145	COG0488	(ABC) transporter
VA249_RS13155	COG0429	hydrolase of the alpha beta-hydrolase fold
VA249_RS13160	COG3089	Belongs to the UPF0270 family
VA249_RS13165	COG3954	Phosphoribulokinase
VA249_RS13170	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VA249_RS13190	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
VA249_RS13205	COG0546	phosphoglycolate phosphatase activity
VA249_RS13210	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VA249_RS13215	COG0557	exoribonuclease II activity
VA249_RS13225	COG1017	nitric oxide dioxygenase activity
VA249_RS13225	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VA249_RS13230	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
VA249_RS13235	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
VA249_RS13240	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
VA249_RS13245	COG0330	HflC and HflK could
VA249_RS13250	COG0330	HflC and HflK could
VA249_RS13255	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
VA249_RS13265	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
VA249_RS13270	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
VA249_RS13280	COG0802	atpase or kinase
VA249_RS13285	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
VA249_RS13360	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
VA249_RS13365	COG1162	GTPase activity
VA249_RS13380	COG0471	metal ion transport
VA249_RS13400	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
VA249_RS13405	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VA249_RS13420	COG1045	serine acetyltransferase
VA249_RS13425	COG4942	peptidase
VA249_RS13450	COG1053	succinate dehydrogenase
VA249_RS13455	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
VA249_RS13475	COG1509	lysine 2,3-aminomutase activity
VA249_RS13500	COG0534	Mate efflux family protein
VA249_RS13515	COG3678	ATP-independent chaperone mediated protein folding
VA249_RS13520	COG0745	RESPONSE REGULATOR receiver
VA249_RS13525	COG2205	protein histidine kinase activity
VA249_RS13530	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
VA249_RS13535	COG3030	protein affecting phage T7 exclusion by the F plasmid
VA249_RS13540	COG1027	Aspartate ammonia-lyase
VA249_RS13545	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VA249_RS13550	COG4232	protein-disulfide reductase activity
VA249_RS13560	COG2095	MarC family integral membrane protein
VA249_RS13570	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VA249_RS13580	COG2205	protein histidine kinase activity
VA249_RS13580	COG0784	Response regulator, receiver
VA249_RS13580	COG2198	Histidine kinase
VA249_RS13585	COG2814	Major facilitator Superfamily
VA249_RS13600	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VA249_RS13605	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
VA249_RS13610	COG0511	ligase activity, forming carbon-carbon bonds
VA249_RS13615	COG0439	Biotin carboxylase
VA249_RS13625	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VA249_RS13630	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
VA249_RS13635	COG2199	diguanylate cyclase activity
VA249_RS13715	COG1982	Orn Lys Arg decarboxylase major
VA249_RS13720	COG0531	amino acid
VA249_RS13725	COG3710	Transcriptional regulator
VA249_RS13730	COG0789	Transcriptional regulator
VA249_RS13735	COG0138	bifunctional purine biosynthesis protein purh
VA249_RS13740	COG0151	Belongs to the GarS family
VA249_RS13760	COG1253	flavin adenine dinucleotide binding
VA249_RS13780	COG1573	uracil-dna glycosylase
VA249_RS13790	COG2816	NAD+ diphosphatase activity
VA249_RS13795	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
VA249_RS13800	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
VA249_RS13815	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
VA249_RS13820	COG0081	regulation of translation
VA249_RS13830	COG0250	Participates in transcription elongation, termination and antitermination
VA249_RS13835	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VA249_RS13865	COG1072	(Pantothenic acid kinase))
VA249_RS13875	COG0812	UDP-N-acetylmuramate dehydrogenase activity
VA249_RS13885	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VA249_RS13950	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VA249_RS13955	COG0534	Mate efflux family protein
VA249_RS13970	COG2937	Belongs to the GPAT DAPAT family
VA249_RS13985	COG3161	chorismate lyase activity
VA249_RS13990	COG1580	Controls the rotational direction of flagella during chemotaxis
VA249_RS13995	COG0705	Rhomboid family
VA249_RS14010	COG2177	Part of the ABC transporter FtsEX involved in
VA249_RS14015	COG2884	Cell division ATP-binding protein ftsE
VA249_RS14020	COG0552	protein localization to endoplasmic reticulum
VA249_RS14025	COG0742	ribosomal rna small subunit methyltransferase
VA249_RS14075	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VA249_RS14080	COG0640	Transcriptional regulator
VA249_RS14085	COG1280	lysine exporter protein (LysE YggA)
VA249_RS14090	COG2267	carboxylic ester hydrolase activity
VA249_RS14095	COG0561	phosphatase activity
VA249_RS14110	COG3148	PFAM DTW domain containing protein
VA249_RS14115	COG1011	Hydrolase
VA249_RS14120	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
VA249_RS14135	COG0019	diaminopimelate decarboxylase activity
VA249_RS14145	COG1965	Belongs to the frataxin family
VA249_RS14160	COG1587	Uroporphyrinogen-III synthase
VA249_RS14165	COG2959	enzyme of heme biosynthesis
VA249_RS14210	COG0633	Ferredoxin
VA249_RS14215	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
VA249_RS14230	COG3118	belongs to the thioredoxin family
VA249_RS14240	COG0248	Ppx GppA phosphatase
VA249_RS14245	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
VA249_RS14255	COG0514	ATP-dependent DNA helicase (RecQ)
VA249_RS14260	COG2962	Rard protein
VA249_RS14270	COG1280	lysine exporter protein (LysE YggA)
VA249_RS14275	COG0405	Gamma-glutamyltransferase
VA249_RS14280	COG0210	DNA helicase
VA249_RS14290	COG3220	belongs to the UPF0276 family
VA249_RS14310	COG2814	Major facilitator Superfamily
VA249_RS14320	COG0006	proline dipeptidase activity
VA249_RS14320	COG0006	proline dipeptidase activity
VA249_RS14335	COG2104	thiamine diphosphate biosynthetic process
VA249_RS14340	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VA249_RS14395	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
VA249_RS14420	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
VA249_RS14425	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
VA249_RS14430	COG0551	DNA topoisomerase type I activity
VA249_RS14440	COG0758	DNA mediated transformation
VA249_RS14450	COG0242	peptide deformylase activity
VA249_RS14460	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VA249_RS14460	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VA249_RS14465	COG0569	domain protein
VA249_RS14470	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VA249_RS14480	COG1272	protein, Hemolysin III
VA249_RS14485	COG4326	sporulation control protein
VA249_RS14495	COG3084	Protein conserved in bacteria
VA249_RS14505	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
VA249_RS14510	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VA249_RS14515	COG0204	Acyl-transferase
VA249_RS14525	COG0606	chelatase, subunit chli
VA249_RS14535	COG3978	acetolactate synthase activity
VA249_RS14540	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VA249_RS14545	COG0129	dihydroxy-acid dehydratase activity
VA249_RS14555	COG0583	DNA-binding transcription factor activity
VA249_RS14560	COG2814	Major facilitator Superfamily
VA249_RS14570	COG0355	proton-transporting ATP synthase activity, rotational mechanism
VA249_RS14575	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
VA249_RS14580	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
VA249_RS14585	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
VA249_RS14595	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
VA249_RS14610	COG3312	ion transport
VA249_RS14615	COG1475	DNA binding
VA249_RS14620	COG1192	Involved in chromosome partitioning
VA249_RS14630	COG0445	tRNA wobble uridine modification
VA249_RS14635	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VA249_RS14645	COG0706	membrane insertase activity
VA249_RS14655	COG0594	ribonuclease P activity
VA249_RS14665	COG1126	abc transporter atp-binding protein
VA249_RS14690	COG0395	ABC-type sugar transport system, permease component
VA249_RS14695	COG2723	6-phospho-beta-galactosidase activity
VA249_RS14700	COG3842	ATPase activity
VA249_RS14705	COG1609	Transcriptional regulator
VA249_RS14715	COG0747	negative chemotaxis
VA249_RS14725	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VA249_RS14730	COG0444	Belongs to the ABC transporter superfamily
VA249_RS14735	COG4608	Belongs to the ABC transporter superfamily
VA249_RS14745	COG1609	Transcriptional regulator
VA249_RS14765	COG1472	Belongs to the glycosyl hydrolase 3 family
VA249_RS14770	COG0534	Mate efflux family protein
VA249_RS14780	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
VA249_RS14785	COG0564	pseudouridine synthase activity
VA249_RS14790	COG0561	phosphatase activity
VA249_RS14800	COG2199	diguanylate cyclase activity
VA249_RS14810	COG3152	Membrane
VA249_RS14820	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
VA249_RS14825	COG2162	N-hydroxyarylamine O-acetyltransferase activity
VA249_RS14830	COG0583	DNA-binding transcription factor activity
VA249_RS14865	COG2076	Multidrug Resistance protein
VA249_RS14875	COG0534	Mate efflux family protein
VA249_RS14890	COG1357	PFAM Pentapeptide repeats (8 copies)
VA249_RS14895	COG3047	cAMP biosynthetic process
VA249_RS14900	COG2358	TRAP transporter, solute receptor (TAXI family
VA249_RS14915	COG2814	Major facilitator Superfamily
VA249_RS15005	COG3005	denitrification pathway
VA249_RS15010	COG0243	molybdopterin cofactor binding
VA249_RS15030	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
VA249_RS15035	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VA249_RS15040	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VA249_RS15045	COG1116	anion transmembrane transporter activity
VA249_RS15050	COG0351	phosphomethylpyrimidine kinase
VA249_RS15055	COG0312	modulator of DNA gyrase
VA249_RS15060	COG0312	modulator of DNA gyrase
VA249_RS15130	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VA249_RS15140	COG0584	glycerophosphoryl diester phosphodiesterase
VA249_RS15145	COG0745	RESPONSE REGULATOR receiver
VA249_RS15165	COG0811	peptide transport
VA249_RS15170	COG0811	peptide transport
VA249_RS15175	COG0848	biopolymer transport protein
VA249_RS15195	COG1770	oligopeptidase
VA249_RS15200	COG2814	Major facilitator Superfamily
VA249_RS15205	COG0010	Belongs to the arginase family
VA249_RS15210	COG1166	arginine decarboxylase activity
VA249_RS15220	COG0189	ligase activity
VA249_RS15220	COG4067	protein conserved in archaea
VA249_RS15225	COG0189	ligase activity
VA249_RS15230	COG0583	DNA-binding transcription factor activity
VA249_RS15255	COG2204	response regulator
VA249_RS15260	COG3706	GGDEF domain
VA249_RS15265	COG1114	Component of the transport system for branched-chain amino acids
VA249_RS15280	COG0579	oxidoreductase
VA249_RS15295	COG3033	Beta-eliminating lyase
VA249_RS15310	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VA249_RS15335	COG3706	GGDEF domain
VA249_RS15340	COG0415	Belongs to the DNA photolyase family
VA249_RS15345	COG3046	protein related to deoxyribodipyrimidine photolyase
VA249_RS15360	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VA249_RS15360	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VA249_RS15365	COG1765	OsmC-like protein
VA249_RS15390	COG1011	Hydrolase
VA249_RS15410	COG3264	Mechanosensitive ion channel
VA249_RS15410	COG1511	domain protein
VA249_RS15415	COG2866	Carboxypeptidase
VA249_RS15435	COG3104	oligopeptide transport
VA249_RS15440	COG1760	l-serine dehydratase
VA249_RS15465	COG0741	lytic transglycosylase activity
VA249_RS15465	COG1388	LysM domain
VA249_RS15485	COG1815	bacterial-type flagellum-dependent cell motility
VA249_RS15490	COG1558	bacterial-type flagellum-dependent cell motility
VA249_RS15495	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
VA249_RS15505	COG4787	bacterial-type flagellum-dependent cell motility
VA249_RS15510	COG4786	Flagellar basal body rod
VA249_RS15515	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
VA249_RS15520	COG1706	bacterial-type flagellum-dependent cell motility
VA249_RS15530	COG4786	Flagellar basal body rod
VA249_RS15530	COG1256	bacterial-type flagellum assembly
VA249_RS15550	COG2089	acid synthase
VA249_RS15580	COG0583	DNA-binding transcription factor activity
VA249_RS15605	COG1360	Flagellar Motor Protein
VA249_RS15610	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
VA249_RS15615	COG1191	sigma factor activity
VA249_RS15620	COG1580	Controls the rotational direction of flagella during chemotaxis
VA249_RS15635	COG1516	flagellar protein fliS
VA249_RS15640	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
VA249_RS15655	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VA249_RS15680	COG1987	bacterial-type flagellum assembly
VA249_RS15710	COG1677	Flagellar hook-basal body complex protein FliE
VA249_RS15755	COG0346	lactoylglutathione lyase activity
VA249_RS15780	COG0745	RESPONSE REGULATOR receiver
VA249_RS15805	COG0156	8-amino-7-oxononanoate synthase activity
VA249_RS15810	COG1063	alcohol dehydrogenase
VA249_RS15850	COG0668	transmembrane transport
VA249_RS15860	COG1304	FMN binding
VA249_RS15865	COG0583	DNA-binding transcription factor activity
VA249_RS15870	COG1505	serine-type exopeptidase activity
VA249_RS15880	COG1067	ATP-dependent peptidase activity
VA249_RS15895	COG1247	-acetyltransferase
VA249_RS15900	COG0437	4 iron, 4 sulfur cluster binding
VA249_RS15905	COG0348	domain, Protein
VA249_RS15910	COG0640	Transcriptional regulator
VA249_RS15925	COG1122	ATPase activity
VA249_RS15935	COG1566	PFAM secretion protein HlyD family protein
VA249_RS15965	COG0813	purine-nucleoside phosphorylase activity
VA249_RS15970	COG3272	Protein of unknown function (DUF1722)
VA249_RS15980	COG0415	Belongs to the DNA photolyase family
VA249_RS15985	COG1376	ErfK ybiS ycfS ynhG family protein
VA249_RS15985	COG1388	LysM domain
VA249_RS15995	COG0513	Belongs to the DEAD box helicase family
VA249_RS16005	COG0573	inorganic phosphate transmembrane transporter activity
VA249_RS16010	COG0581	inorganic phosphate transmembrane transporter activity
VA249_RS16015	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VA249_RS16020	COG3706	GGDEF domain
VA249_RS16030	COG2304	oxidoreductase activity
VA249_RS16050	COG0714	Associated with various cellular activities
VA249_RS16055	COG0840	transmembrane signaling receptor activity
VA249_RS16065	COG2197	response regulator
VA249_RS16070	COG0110	maltose O-acetyltransferase activity
VA249_RS16075	COG1028	Short-chain dehydrogenase reductase Sdr
VA249_RS16080	COG5001	Diguanylate cyclase
VA249_RS16080	COG2203	Gaf domain
VA249_RS16080	COG4251	negative regulation of phosphorylation
VA249_RS16080	COG3706	GGDEF domain
VA249_RS16105	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VA249_RS16110	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VA249_RS16115	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
VA249_RS16125	COG1252	NADH dehydrogenase
VA249_RS16130	COG1301	dicarboxylic acid transport
VA249_RS16135	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VA249_RS16140	COG2706	6-phosphogluconolactonase activity
VA249_RS16145	COG1881	PFAM PEBP family protein
VA249_RS16155	COG0798	PFAM Bile acid sodium symporter
VA249_RS16185	COG0814	amino acid
VA249_RS16195	COG3314	Sporulation integral membrane protein YlbJ
VA249_RS16215	COG0739	heme binding
VA249_RS16225	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VA249_RS16230	COG0697	spore germination
VA249_RS16245	COG0179	Fumarylacetoacetate (FAA) hydrolase
VA249_RS16260	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
VA249_RS16265	COG1280	lysine exporter protein (LysE YggA)
VA249_RS16270	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VA249_RS16275	COG1565	acr, cog1565
VA249_RS16275	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
VA249_RS16285	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
VA249_RS16290	COG1845	cytochrome c oxidase, subunit III
VA249_RS16310	COG1612	heme a metabolic process
VA249_RS16325	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VA249_RS16330	COG0840	transmembrane signaling receptor activity
VA249_RS16335	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VA249_RS16355	COG2897	thiosulfate sulfurtransferase activity
VA249_RS16375	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VA249_RS16380	COG0303	'Molybdopterin
VA249_RS16390	COG1914	H( )-stimulated, divalent metal cation uptake system
VA249_RS16415	COG4989	oxidoreductase activity
VA249_RS16430	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
VA249_RS16430	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
VA249_RS16440	COG0814	amino acid
VA249_RS16445	COG1360	Flagellar Motor Protein
VA249_RS16450	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
VA249_RS16455	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VA249_RS16455	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
VA249_RS16455	COG1013	pyruvate-flavodoxin oxidoreductase activity
VA249_RS16455	COG0674	pyruvate-flavodoxin oxidoreductase activity
VA249_RS16465	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VA249_RS16470	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VA249_RS16475	COG1757	Na H antiporter
VA249_RS16480	COG0786	glutamate:sodium symporter activity
VA249_RS16490	COG0745	RESPONSE REGULATOR receiver
VA249_RS16495	COG2205	protein histidine kinase activity
VA249_RS16515	COG1247	-acetyltransferase
VA249_RS16530	COG1566	PFAM secretion protein HlyD family protein
VA249_RS16540	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
VA249_RS16545	COG0076	glutamate decarboxylase activity
VA249_RS16580	COG4176	ABC-type proline glycine betaine transport system permease component
VA249_RS16585	COG0517	IMP dehydrogenase activity
VA249_RS16585	COG4175	Glycine betaine
VA249_RS16610	COG5001	Diguanylate cyclase
VA249_RS16610	COG3300	MHYT domain
VA249_RS16615	COG2205	protein histidine kinase activity
VA249_RS16615	COG0784	Response regulator, receiver
VA249_RS16665	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
VA249_RS16675	COG0297	glycogen (starch) synthase activity
VA249_RS16675	COG0438	transferase activity, transferring glycosyl groups
VA249_RS16705	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
VA249_RS16710	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
VA249_RS16715	COG3206	protein involved in exopolysaccharide biosynthesis
VA249_RS16715	COG0489	protein tyrosine kinase activity
VA249_RS16730	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VA249_RS16760	COG1794	racemase activity, acting on amino acids and derivatives
VA249_RS16770	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
VA249_RS16775	COG5001	Diguanylate cyclase
VA249_RS16780	COG1869	D-ribose catabolic process
VA249_RS16785	COG0738	Major facilitator superfamily
VA249_RS16795	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VA249_RS16800	COG1609	Transcriptional regulator
VA249_RS16810	COG0789	Transcriptional regulator
VA249_RS16830	COG1289	transmembrane transporter activity
VA249_RS16835	COG0210	DNA helicase
VA249_RS16845	COG1879	ABC-type sugar transport system periplasmic component
VA249_RS16850	COG0784	Response regulator, receiver
VA249_RS16850	COG2205	protein histidine kinase activity
VA249_RS16850	COG2198	Histidine kinase
VA249_RS16870	COG3119	arylsulfatase activity
VA249_RS16875	COG3119	arylsulfatase activity
VA249_RS16880	COG3063	Type IV pilus biogenesis stability protein PilW
VA249_RS16885	COG0714	Associated with various cellular activities
VA249_RS16920	COG0583	DNA-binding transcription factor activity
VA249_RS16925	COG3111	PFAM Bacterial OB fold (BOF) protein
VA249_RS16945	COG0641	radical SAM
VA249_RS16970	COG3069	C4-dicarboxylate transmembrane transporter activity
VA249_RS16995	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
VA249_RS17000	COG0778	Nitroreductase
VA249_RS17005	COG0784	Response regulator, receiver
VA249_RS17005	COG0835	chemotaxis
VA249_RS17010	COG2165	general secretion pathway protein
VA249_RS17020	COG2962	Rard protein
VA249_RS17025	COG3788	relative of glutathione S-transferase, MAPEG superfamily
VA249_RS17035	COG0671	phosphoesterase, PA-phosphatase related
VA249_RS17065	COG2067	long-chain fatty acid transport protein
VA249_RS17080	COG1902	pentaerythritol trinitrate reductase activity
VA249_RS17085	COG0346	lactoylglutathione lyase activity
VA249_RS17090	COG0420	3'-5' exonuclease activity
VA249_RS17095	COG0419	ATPase involved in DNA repair
VA249_RS17105	COG3469	chitinase activity
VA249_RS17125	COG3040	lipid binding
VA249_RS17140	COG0509	glycine decarboxylation via glycine cleavage system
VA249_RS17145	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VA249_RS17185	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VA249_RS17185	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VA249_RS17185	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
VA249_RS17190	COG1105	Belongs to the carbohydrate kinase PfkB family
VA249_RS17195	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VA249_RS17195	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
VA249_RS17200	COG1609	Transcriptional regulator
VA249_RS17220	COG0668	transmembrane transport
VA249_RS17240	COG2239	Acts as a magnesium transporter
VA249_RS17250	COG0387	Pfam Sodium calcium exchanger
VA249_RS17260	COG0765	amino acid transport
VA249_RS17265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VA249_RS17270	COG0765	amino acid transport
VA249_RS17275	COG1126	abc transporter atp-binding protein
VA249_RS17280	COG1979	alcohol dehydrogenase
VA249_RS17285	COG2207	Transcriptional regulator
VA249_RS17290	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
VA249_RS17300	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VA249_RS17315	COG3437	response regulator, receiver
VA249_RS17315	COG0784	Response regulator, receiver
VA249_RS17320	COG0546	phosphoglycolate phosphatase activity
VA249_RS17325	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
VA249_RS17330	COG0513	Belongs to the DEAD box helicase family
VA249_RS17345	COG3038	cytochrome b561
VA249_RS17355	COG2116	formate transmembrane transporter activity
VA249_RS17360	COG0583	DNA-binding transcription factor activity
VA249_RS17370	COG3593	DNA synthesis involved in DNA repair
VA249_RS17375	COG0737	Belongs to the 5'-nucleotidase family
VA249_RS17380	COG0861	Integral membrane protein TerC family
VA249_RS17400	COG2267	carboxylic ester hydrolase activity
VA249_RS17405	COG2067	long-chain fatty acid transport protein
VA249_RS17420	COG2050	protein possibly involved in aromatic compounds catabolism
VA249_RS17430	COG4533	DNA binding
VA249_RS17455	COG0484	heat shock protein binding
VA249_RS17465	COG3300	MHYT domain
VA249_RS17465	COG5001	Diguanylate cyclase
VA249_RS17470	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VA249_RS17480	COG4181	ATPase activity
VA249_RS17485	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
VA249_RS17495	COG1984	allophanate hydrolase subunit 2
VA249_RS17500	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
VA249_RS17510	COG5002	protein histidine kinase activity
VA249_RS17510	COG5001	Diguanylate cyclase
VA249_RS17510	COG3447	MASE1 domain protein
VA249_RS17525	COG0583	DNA-binding transcription factor activity
VA249_RS17530	COG1042	CoA-binding domain protein
VA249_RS17530	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VA249_RS17530	COG0045	succinate-CoA ligase (ADP-forming) activity
VA249_RS17550	COG0023	Translation Initiation Factor
VA249_RS17575	COG3140	Belongs to the UPF0181 family
VA249_RS17600	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
VA249_RS17605	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
VA249_RS17635	COG2203	Gaf domain
VA249_RS17635	COG4251	negative regulation of phosphorylation
VA249_RS17635	COG3706	GGDEF domain
VA249_RS17635	COG5001	Diguanylate cyclase
VA249_RS17645	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
VA249_RS17650	COG4149	molybdate abc transporter
VA249_RS17665	COG3111	PFAM Bacterial OB fold (BOF) protein
VA249_RS17675	COG0189	ligase activity
VA249_RS17675	COG4067	protein conserved in archaea
VA249_RS17690	COG0534	Mate efflux family protein
VA249_RS17695	COG0602	queuosine metabolic process
VA249_RS17700	COG1328	CTP reductase activity
VA249_RS17740	COG0402	S-adenosylhomocysteine deaminase activity
VA249_RS17775	COG0628	permease
VA249_RS17785	COG1566	PFAM secretion protein HlyD family protein
VA249_RS17800	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VA249_RS17805	COG3118	belongs to the thioredoxin family
VA249_RS17845	COG2116	formate transmembrane transporter activity
VA249_RS17855	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VA249_RS17860	COG3706	GGDEF domain
VA249_RS17910	COG0277	FAD linked oxidase domain protein
VA249_RS17920	COG2425	protein containing a von Willebrand factor type A (vWA) domain
VA249_RS17935	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
VA249_RS17945	COG1288	antiporter activity
VA249_RS17955	COG2814	Major facilitator Superfamily
VA249_RS17975	COG0583	DNA-binding transcription factor activity
VA249_RS17995	COG1132	(ABC) transporter
VA249_RS18030	COG0318	PFAM AMP-dependent synthetase and ligase
VA249_RS18060	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VA249_RS18070	COG0786	glutamate:sodium symporter activity
VA249_RS18075	COG0628	permease
VA249_RS18115	COG2146	nitrite reductase [NAD(P)H] activity
VA249_RS18115	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VA249_RS18120	COG1116	anion transmembrane transporter activity
VA249_RS18125	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VA249_RS18130	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VA249_RS18135	COG3707	response regulator
VA249_RS18150	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VA249_RS18150	COG1648	precorrin-2 dehydrogenase activity
VA249_RS18155	COG0243	molybdopterin cofactor binding
VA249_RS18165	COG0814	amino acid
VA249_RS18185	COG1785	Belongs to the alkaline phosphatase family
VA249_RS18190	COG5002	protein histidine kinase activity
VA249_RS18195	COG0745	RESPONSE REGULATOR receiver
VA249_RS18215	COG0443	Heat shock 70 kDa protein
VA249_RS18230	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
VA249_RS18265	COG1053	succinate dehydrogenase
VA249_RS18265	COG3976	FMN-binding domain protein
VA249_RS18265	COG0431	NADPH-dependent FMN reductase
VA249_RS18270	COG0625	glutathione transferase activity
VA249_RS18290	COG4160	amino acid transport
VA249_RS18295	COG4215	(ABC) transporter
VA249_RS18300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VA249_RS18305	COG1126	abc transporter atp-binding protein
VA249_RS18325	COG0446	pyridine nucleotide-disulphide oxidoreductase
VA249_RS18325	COG1902	pentaerythritol trinitrate reductase activity
VA249_RS18330	COG1028	Short-chain dehydrogenase reductase Sdr
VA249_RS18340	COG1024	Enoyl-CoA hydratase
VA249_RS18345	COG1024	Enoyl-CoA hydratase
VA249_RS18360	COG0183	Belongs to the thiolase family
VA249_RS18370	COG1960	acyl-CoA dehydrogenase activity
VA249_RS18375	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
VA249_RS18380	COG1024	Enoyl-CoA hydratase
VA249_RS18400	COG3278	Belongs to the heme-copper respiratory oxidase family
VA249_RS18415	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
VA249_RS18420	COG0513	Belongs to the DEAD box helicase family
VA249_RS18425	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
VA249_RS18440	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
VA249_RS18470	COG0583	DNA-binding transcription factor activity
VA249_RS18475	COG1073	alpha beta
VA249_RS18530	COG3706	GGDEF domain
VA249_RS18535	COG2252	PERMEase
VA249_RS18540	COG1119	ATPase activity
VA249_RS18560	COG0513	Belongs to the DEAD box helicase family
VA249_RS18565	COG0523	cobalamin synthesis protein
VA249_RS18595	COG3416	Protein conserved in bacteria
VA249_RS18610	COG3530	Putative quorum-sensing-regulated virulence factor
VA249_RS18640	COG3186	Phenylalanine-4-hydroxylase
VA249_RS18645	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VA249_RS18650	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VA249_RS18675	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
VA249_RS18680	COG1454	alcohol dehydrogenase
VA249_RS18685	COG2133	pyrroloquinoline quinone binding
VA249_RS18695	COG0783	Belongs to the Dps family
VA249_RS18710	COG0577	efflux transmembrane transporter activity
VA249_RS18710	COG1136	(ABC) transporter
VA249_RS18715	COG0577	efflux transmembrane transporter activity
VA249_RS18715	COG1136	(ABC) transporter
VA249_RS18730	COG1278	Cold shock
VA249_RS18760	COG0545	Peptidyl-prolyl cis-trans isomerase
VA249_RS18785	COG2197	response regulator
VA249_RS18790	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VA249_RS18800	COG0840	transmembrane signaling receptor activity
VA249_RS18820	COG2195	Cleaves the N-terminal amino acid of tripeptides
VA249_RS18835	COG2197	response regulator
VA249_RS18840	COG3850	Histidine kinase
VA249_RS18845	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VA249_RS18865	COG3005	denitrification pathway
VA249_RS18885	COG0183	Belongs to the thiolase family
VA249_RS18895	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VA249_RS18900	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VA249_RS18915	COG1522	sequence-specific DNA binding
VA249_RS18935	COG2827	Endonuclease containing a URI domain
VA249_RS18960	COG0673	inositol 2-dehydrogenase activity
VA249_RS19040	COG0583	DNA-binding transcription factor activity
VA249_RS19065	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VA249_RS19085	COG1566	PFAM secretion protein HlyD family protein
VA249_RS19090	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
VA249_RS19095	COG2239	Acts as a magnesium transporter
VA249_RS19100	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
VA249_RS19105	COG0402	S-adenosylhomocysteine deaminase activity
VA249_RS19120	COG1418	mRNA catabolic process
VA249_RS19130	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VA249_RS19145	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VA249_RS19160	COG4221	oxidoreductase activity
VA249_RS19165	COG0745	RESPONSE REGULATOR receiver
VA249_RS19170	COG2205	protein histidine kinase activity
VA249_RS19180	COG2194	sulfuric ester hydrolase activity
VA249_RS19195	COG2814	Major facilitator Superfamily
VA249_RS19220	COG0583	DNA-binding transcription factor activity
VA249_RS19225	COG2249	NAD(P)H dehydrogenase (quinone) activity
VA249_RS19240	COG0583	DNA-binding transcription factor activity
VA249_RS19265	COG0366	Alpha amylase catalytic
VA249_RS19270	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VA249_RS19275	COG0835	chemotaxis
VA249_RS19275	COG0784	Response regulator, receiver
VA249_RS19285	COG0748	coenzyme F420 binding
VA249_RS19290	COG3721	Heme iron utilization protein
VA249_RS19300	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
VA249_RS19305	COG0811	peptide transport
VA249_RS19310	COG0848	biopolymer transport protein
VA249_RS19320	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VA249_RS19325	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
VA249_RS19370	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
VA249_RS19380	COG3217	Mosc domain protein beta barrel domain protein
VA249_RS19380	COG0633	Ferredoxin
VA249_RS19380	COG3217	Mosc domain protein beta barrel domain protein
VA249_RS19380	COG0633	Ferredoxin
VA249_RS19385	COG0401	homolog of Blt101
VA249_RS19395	COG2354	Protein conserved in bacteria
VA249_RS19410	COG1196	nuclear chromosome segregation
VA249_RS19435	COG1349	DNA-binding transcription factor activity
VA249_RS19445	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VA249_RS19450	COG0738	Major facilitator superfamily
VA249_RS19480	COG3833	ABC-type maltose transport systems, permease component
VA249_RS19485	COG1175	transmembrane transport
VA249_RS19500	COG3842	ATPase activity
VA249_RS19510	COG1309	transcriptional regulator
VA249_RS19515	COG2130	NADP-dependent
VA249_RS19525	COG0753	catalase activity
VA249_RS19530	COG2084	Dehydrogenase
VA249_RS19540	COG0583	DNA-binding transcription factor activity
VA249_RS19545	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VA249_RS19550	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VA249_RS19560	COG2207	Transcriptional regulator
VA249_RS19565	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VA249_RS19565	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VA249_RS19565	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VA249_RS19570	COG1482	cell wall glycoprotein biosynthetic process
VA249_RS19575	COG2211	Major facilitator Superfamily
VA249_RS19580	COG1486	melibiose metabolic process
VA249_RS19585	COG2169	Transcriptional regulator
VA249_RS19595	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
VA249_RS19605	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VA249_RS19610	COG2249	NAD(P)H dehydrogenase (quinone) activity
VA249_RS19615	COG2233	PERMEase
VA249_RS19620	COG0402	S-adenosylhomocysteine deaminase activity
VA249_RS19635	COG3383	formate dehydrogenase (NAD+) activity
VA249_RS19655	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VA249_RS19680	COG0604	alcohol dehydrogenase
VA249_RS19680	COG1028	Short-chain dehydrogenase reductase Sdr
VA249_RS19680	COG3321	synthase
VA249_RS19700	COG1247	-acetyltransferase
VA249_RS19705	COG1505	serine-type exopeptidase activity
VA249_RS19715	COG0589	response to stress
VA249_RS19735	COG4667	esterase of the alpha-beta hydrolase superfamily
VA249_RS19740	COG1741	Belongs to the pirin family
VA249_RS19745	COG1278	Cold shock
VA249_RS19755	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VA249_RS19755	COG0678	peroxiredoxin activity
VA249_RS19765	COG1686	Belongs to the peptidase S11 family
VA249_RS19770	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VA249_RS19775	COG2249	NAD(P)H dehydrogenase (quinone) activity
VA249_RS19780	COG0583	DNA-binding transcription factor activity
VA249_RS19785	COG0625	glutathione transferase activity
VA249_RS19795	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
VA249_RS19805	COG1028	Short-chain dehydrogenase reductase Sdr
VA249_RS19820	COG1028	Short-chain dehydrogenase reductase Sdr
VA249_RS19830	COG0583	DNA-binding transcription factor activity
VA249_RS19835	COG2207	Transcriptional regulator
VA249_RS19835	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VA249_RS19840	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VA249_RS19870	COG0513	Belongs to the DEAD box helicase family
VA249_RS19890	COG0589	response to stress
VA249_RS19895	COG3122	Protein conserved in bacteria
VA249_RS19910	COG0583	DNA-binding transcription factor activity
VA249_RS19915	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
VA249_RS19920	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
VA249_RS19925	COG1072	(Pantothenic acid kinase))
VA249_RS19935	COG1063	alcohol dehydrogenase
VA249_RS19940	COG2213	PTS system mannitol-specific
VA249_RS19945	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VA249_RS19965	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
VA249_RS19970	COG0574	Belongs to the PEP-utilizing enzyme family
VA249_RS19970	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
VA249_RS19980	COG3302	dmso reductase anchor subunit
VA249_RS19985	COG0437	4 iron, 4 sulfur cluster binding
VA249_RS19990	COG0243	molybdopterin cofactor binding
VA249_RS19995	COG3381	protein complex oligomerization
VA249_RS20010	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VA249_RS20025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VA249_RS20040	COG0786	glutamate:sodium symporter activity
VA249_RS20055	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VA249_RS20075	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VA249_RS20095	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VA249_RS20125	COG3710	Transcriptional regulator
VA249_RS20135	COG3710	Transcriptional regulator
VA249_RS20150	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VA249_RS20170	COG1342	Belongs to the UPF0251 family
VA249_RS20180	COG4176	ABC-type proline glycine betaine transport system permease component
VA249_RS20185	COG3448	diguanylate cyclase activity
VA249_RS20185	COG4175	Glycine betaine
VA249_RS20190	COG3015	lipoprotein NlpE involved in copper resistance
VA249_RS20195	COG0583	DNA-binding transcription factor activity
VA249_RS20235	COG1335	isochorismatase
VA249_RS20260	COG0346	lactoylglutathione lyase activity
VA249_RS20275	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VA249_RS20285	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VA249_RS20310	COG0435	Glutathione S-transferase
VA249_RS20315	COG0431	NADPH-dependent FMN reductase
VA249_RS20320	COG0583	DNA-binding transcription factor activity
VA249_RS20325	COG4628	conserved protein (DUF2132)
VA249_RS20330	COG0488	(ABC) transporter
VA249_RS20345	COG2814	Major facilitator Superfamily
VA249_RS20380	COG0628	permease
VA249_RS20385	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
VA249_RS20395	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VA249_RS20405	COG4628	conserved protein (DUF2132)
VA249_RS20410	COG0583	DNA-binding transcription factor activity
VA249_RS20430	COG1234	tRNA 3'-trailer cleavage
VA249_RS20445	COG1686	Belongs to the peptidase S11 family
VA249_RS20460	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
VA249_RS20470	COG3397	chitin binding
VA249_RS20485	COG0840	transmembrane signaling receptor activity
VA249_RS20490	COG4667	esterase of the alpha-beta hydrolase superfamily
VA249_RS20495	COG1454	alcohol dehydrogenase
VA249_RS20500	COG0235	Class ii aldolase
VA249_RS20505	COG4154	Belongs to the RbsD FucU family
VA249_RS20510	COG1070	Carbohydrate kinase
VA249_RS20515	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
VA249_RS20520	COG0738	Major facilitator superfamily
VA249_RS20525	COG1349	DNA-binding transcription factor activity
VA249_RS20530	COG2095	MarC family integral membrane protein
VA249_RS20535	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VA249_RS20565	COG1301	dicarboxylic acid transport
VA249_RS20570	COG3339	Conserved Protein
VA249_RS20575	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VA249_RS20580	COG0700	Nucleoside recognition
VA249_RS20585	COG3366	ferrous iron transmembrane transporter activity
VA249_RS20590	COG0366	Alpha amylase catalytic
VA249_RS20595	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VA249_RS20600	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
VA249_RS20605	COG1640	4-alpha-glucanotransferase
VA249_RS20610	COG0058	SHG alpha-glucan phosphorylase activity
VA249_RS20630	COG1999	signal sequence binding
VA249_RS20640	COG1263	PTS System
VA249_RS20640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VA249_RS20645	COG1162	GTPase activity
VA249_RS20650	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
VA249_RS20665	COG0531	amino acid
VA249_RS20670	COG1982	Orn Lys Arg decarboxylase major
VA249_RS20695	COG4580	involved in the transport of maltose and maltodextrins
VA249_RS20705	COG3706	GGDEF domain
VA249_RS20725	COG4771	TonB-dependent receptor
VA249_RS20730	COG0583	DNA-binding transcription factor activity
VA249_RS20735	COG4607	ABC-type enterochelin transport system periplasmic component
VA249_RS20740	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VA249_RS20745	COG4605	iron ion homeostasis
VA249_RS20750	COG4604	ABC transporter, ATP-binding protein
VA249_RS20780	COG0583	DNA-binding transcription factor activity
VA249_RS20785	COG1335	isochorismatase
VA249_RS20795	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
VA249_RS20800	COG1304	FMN binding
VA249_RS20805	COG0549	Belongs to the carbamate kinase family
VA249_RS20815	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
VA249_RS20825	COG0826	peptidase U32
VA249_RS20840	COG1136	(ABC) transporter
VA249_RS20845	COG0577	efflux transmembrane transporter activity
VA249_RS20875	COG3634	alkyl hydroperoxide reductase activity
VA249_RS20880	COG1278	Cold shock
VA249_RS20885	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
VA249_RS20890	COG1522	sequence-specific DNA binding
VA249_RS20895	COG0006	proline dipeptidase activity
VA249_RS20920	COG0596	Alpha beta hydrolase
VA249_RS20960	COG0513	Belongs to the DEAD box helicase family
VA249_RS20970	COG0657	acetylesterase activity
VA249_RS20980	COG0583	DNA-binding transcription factor activity
VA249_RS20985	COG1312	Catalyzes the dehydration of D-mannonate
VA249_RS20990	COG0246	Mannitol dehydrogenase
VA249_RS20995	COG1904	glucuronate isomerase
VA249_RS21000	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VA249_RS21005	COG0800	Aldolase
VA249_RS21025	COG3250	beta-galactosidase activity
VA249_RS21035	COG2186	Transcriptional regulator
VA249_RS21055	COG1132	(ABC) transporter
VA249_RS21095	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VA249_RS21120	COG0259	pyridoxamine-phosphate oxidase activity
VA249_RS21175	COG1444	tRNA N-acetyltransferase activity
VA249_RS21215	COG0772	Belongs to the SEDS family
VA249_RS21225	COG1566	PFAM secretion protein HlyD family protein
VA249_RS21240	COG1136	(ABC) transporter
VA249_RS21260	COG3275	phosphorelay sensor kinase activity
VA249_RS21265	COG3279	Response regulator of the LytR AlgR family
VA249_RS21275	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VA249_RS21305	COG1028	Short-chain dehydrogenase reductase Sdr
VA249_RS21330	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VA249_RS21335	COG1999	signal sequence binding
VA249_RS21375	COG0786	glutamate:sodium symporter activity
VA249_RS21385	COG1131	(ABC) transporter
VA249_RS21390	COG0786	glutamate:sodium symporter activity
VA249_RS21425	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
VA249_RS21430	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
VA249_RS21440	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
VA249_RS21470	COG3123	guanosine phosphorylase activity
VA249_RS21485	COG1609	Transcriptional regulator
VA249_RS21495	COG1609	Transcriptional regulator
VA249_RS21530	COG3039	Transposase
VA249_RS21625	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VA249_RS21660	COG0640	Transcriptional regulator
VA249_RS21920	COG1192	Involved in chromosome partitioning
VA249_RS22055	COG1404	Belongs to the peptidase S8 family
VA249_RS22145	COG1793	dna ligase
VA249_RS22205	COG0210	DNA helicase
VA249_RS22420	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
VA249_RS22525	COG0210	DNA helicase
VA249_RS22630	COG0330	HflC and HflK could
VA249_RS22660	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
VA249_RS22705	COG3344	reverse transcriptase
VA249_RS22740	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
VA249_RS22815	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
VA249_RS22835	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
VA249_RS22840	COG1061	Type III restriction enzyme res subunit
VA249_RS22845	COG1002	Type II restriction enzyme, methylase subunits
VA249_RS22960	COG0561	phosphatase activity
VA249_RS22975	COG2160	L-arabinose isomerase activity
VA249_RS22980	COG0235	Class ii aldolase
VA249_RS22985	COG1069	ribulokinase activity
VA249_RS22990	COG1879	ABC-type sugar transport system periplasmic component
VA249_RS22995	COG1129	ABC transporter
VA249_RS23030	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VA249_RS23035	COG0840	transmembrane signaling receptor activity
VA249_RS23045	COG3335	DDE superfamily endonuclease
VA249_RS23050	COG4580	involved in the transport of maltose and maltodextrins
VA249_RS23055	COG1874	Beta-galactosidase
VA249_RS23065	COG3833	ABC-type maltose transport systems, permease component
VA249_RS23070	COG1175	transmembrane transport
VA249_RS23075	COG2182	Extracellular solute-binding protein
VA249_RS23085	COG3842	ATPase activity
VA249_RS23090	COG1840	ABC-type Fe3 transport system, periplasmic component
VA249_RS23100	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
VA249_RS23125	COG1733	regulation of RNA biosynthetic process
VA249_RS23145	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
VA249_RS23150	COG1917	Cupin 2, conserved barrel domain protein
VA249_RS23150	COG2169	Transcriptional regulator
VA249_RS23195	COG0318	PFAM AMP-dependent synthetase and ligase
VA249_RS23200	COG2267	carboxylic ester hydrolase activity
VA249_RS23210	COG1012	belongs to the aldehyde dehydrogenase family
VA249_RS23240	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
VA249_RS23250	COG4569	acetaldehyde dehydrogenase (acetylating) activity
VA249_RS23255	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VA249_RS23260	COG1028	Short-chain dehydrogenase reductase Sdr
VA249_RS23270	COG1192	Involved in chromosome partitioning
VA249_RS23280	COG2814	Major facilitator Superfamily
VA249_RS23295	COG1053	succinate dehydrogenase
VA249_RS23305	COG1028	Short-chain dehydrogenase reductase Sdr
VA249_RS23310	COG1902	pentaerythritol trinitrate reductase activity
VA249_RS23315	COG1028	Short-chain dehydrogenase reductase Sdr
VA249_RS23345	COG0183	Belongs to the thiolase family
VA249_RS23350	COG1024	Enoyl-CoA hydratase
VA249_RS23360	COG3706	GGDEF domain
VA249_RS23390	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VA249_RS23400	COG2244	polysaccharide biosynthetic process
VA249_RS23405	COG1216	Glycosyl transferase, family 2
VA249_RS23415	COG1216	Glycosyl transferase, family 2
VA249_RS23415	COG0463	Glycosyl transferase, family 2
VA249_RS23435	COG2204	response regulator
VA249_RS23445	COG4974	Belongs to the 'phage' integrase family
VA249_RS23455	COG0438	transferase activity, transferring glycosyl groups
VA249_RS23485	COG0546	phosphoglycolate phosphatase activity
VA249_RS23485	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
VA249_RS23490	COG2076	Multidrug Resistance protein
VA249_RS23530	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VA249_RS23555	COG0367	asparagine synthase
VA249_RS23560	COG0297	glycogen (starch) synthase activity
VA249_RS23565	COG0438	transferase activity, transferring glycosyl groups
VA249_RS23570	COG0438	transferase activity, transferring glycosyl groups
VA249_RS23585	COG2176	DNA-directed DNA polymerase activity
VA249_RS23595	COG1213	nucleotidyl transferase
VA249_RS23600	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
VA249_RS23605	COG3848	Pyruvate phosphate dikinase
VA249_RS23605	COG0574	Belongs to the PEP-utilizing enzyme family
VA249_RS23620	COG0471	metal ion transport
VA249_RS23620	COG3273	potassium ion transport
VA249_RS23630	COG1960	acyl-CoA dehydrogenase activity
VA249_RS23635	COG1960	acyl-CoA dehydrogenase activity
VA249_RS23660	COG1028	Short-chain dehydrogenase reductase Sdr
VA249_RS23680	COG2086	electron transfer activity
VA249_RS23700	COG2207	Transcriptional regulator
VA249_RS23710	COG1960	acyl-CoA dehydrogenase activity
VA249_RS23735	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VA249_RS23740	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VA249_RS23745	COG0387	Pfam Sodium calcium exchanger
VA249_RS23755	COG2239	Acts as a magnesium transporter
VA249_RS23765	COG0583	DNA-binding transcription factor activity
VA249_RS23770	COG0668	transmembrane transport
VA249_RS23785	COG1566	PFAM secretion protein HlyD family protein
VA249_RS23790	COG0628	permease
VA249_RS23800	COG0653	protein targeting
VA249_RS23805	COG4115	mRNA cleavage
VA249_RS23810	COG2161	toxin-antitoxin pair type II binding
VA249_RS23820	COG1028	Short-chain dehydrogenase reductase Sdr
VA249_RS23825	COG0183	Belongs to the thiolase family
VA249_RS23830	COG1960	acyl-CoA dehydrogenase activity
VA249_RS23835	COG1960	acyl-CoA dehydrogenase activity
VA249_RS23850	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
VA249_RS23855	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
VA249_RS23865	COG0346	lactoylglutathione lyase activity
VA249_RS23900	COG0583	DNA-binding transcription factor activity
VA249_RS23905	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VA249_RS23915	COG2272	Belongs to the type-B carboxylesterase lipase family
VA249_RS23930	COG2860	membrane
VA249_RS23945	COG0729	surface antigen
VA249_RS23950	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
VA249_RS23960	COG3547	Transposase (IS116 IS110 IS902 family)
VA249_RS24000	COG2188	Transcriptional regulator