locus-tag	class	description
K5706_RS00010	COG0592	DNA-directed DNA polymerase activity
K5706_RS00020	COG0187	DNA topoisomerase II activity
K5706_RS00025	COG0071	Belongs to the small heat shock protein (HSP20) family
K5706_RS00030	COG3977	Valine--pyruvate aminotransferase
K5706_RS00045	COG2119	membrane
K5706_RS00055	COG0425	Belongs to the sulfur carrier protein TusA family
K5706_RS00070	COG0604	alcohol dehydrogenase
K5706_RS00075	COG0183	Belongs to the thiolase family
K5706_RS00085	COG1739	Uncharacterized protein family UPF0029
K5706_RS00090	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K5706_RS00150	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K5706_RS00155	COG2104	thiamine diphosphate biosynthetic process
K5706_RS00170	COG0006	proline dipeptidase activity
K5706_RS00170	COG0006	proline dipeptidase activity
K5706_RS00180	COG2814	Major facilitator Superfamily
K5706_RS00200	COG3220	belongs to the UPF0276 family
K5706_RS00210	COG0210	DNA helicase
K5706_RS00215	COG0405	Gamma-glutamyltransferase
K5706_RS00220	COG1280	lysine exporter protein (LysE YggA)
K5706_RS00230	COG2962	Rard protein
K5706_RS00235	COG0514	ATP-dependent DNA helicase (RecQ)
K5706_RS00245	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
K5706_RS00250	COG0248	Ppx GppA phosphatase
K5706_RS00260	COG3118	belongs to the thioredoxin family
K5706_RS00275	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
K5706_RS00280	COG0633	Ferredoxin
K5706_RS00325	COG2959	enzyme of heme biosynthesis
K5706_RS00330	COG1587	Uroporphyrinogen-III synthase
K5706_RS00345	COG1965	Belongs to the frataxin family
K5706_RS00355	COG0019	diaminopimelate decarboxylase activity
K5706_RS00370	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
K5706_RS00375	COG1011	Hydrolase
K5706_RS00380	COG3148	PFAM DTW domain containing protein
K5706_RS00395	COG0561	phosphatase activity
K5706_RS00400	COG2267	carboxylic ester hydrolase activity
K5706_RS00405	COG1280	lysine exporter protein (LysE YggA)
K5706_RS00410	COG0640	Transcriptional regulator
K5706_RS00415	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K5706_RS00465	COG0742	ribosomal rna small subunit methyltransferase
K5706_RS00470	COG0552	protein localization to endoplasmic reticulum
K5706_RS00475	COG2884	Cell division ATP-binding protein ftsE
K5706_RS00480	COG2177	Part of the ABC transporter FtsEX involved in
K5706_RS00495	COG0705	Rhomboid family
K5706_RS00500	COG1580	Controls the rotational direction of flagella during chemotaxis
K5706_RS00505	COG3161	chorismate lyase activity
K5706_RS00515	COG2937	Belongs to the GPAT DAPAT family
K5706_RS00530	COG0534	Mate efflux family protein
K5706_RS00535	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K5706_RS00600	COG0582	viral genome integration into host DNA
K5706_RS00645	COG1486	melibiose metabolic process
K5706_RS00650	COG2188	Transcriptional regulator
K5706_RS00680	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K5706_RS00690	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K5706_RS00730	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K5706_RS00735	COG0250	Participates in transcription elongation, termination and antitermination
K5706_RS00745	COG0081	regulation of translation
K5706_RS00750	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K5706_RS00765	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K5706_RS00770	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
K5706_RS00775	COG2816	NAD+ diphosphatase activity
K5706_RS00785	COG1573	uracil-dna glycosylase
K5706_RS00800	COG1253	flavin adenine dinucleotide binding
K5706_RS00820	COG0138	bifunctional purine biosynthesis protein purh
K5706_RS00825	COG0789	Transcriptional regulator
K5706_RS00830	COG3710	Transcriptional regulator
K5706_RS00835	COG0531	amino acid
K5706_RS00840	COG1982	Orn Lys Arg decarboxylase major
K5706_RS00945	COG2199	diguanylate cyclase activity
K5706_RS00950	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
K5706_RS00955	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K5706_RS00965	COG0439	Biotin carboxylase
K5706_RS00970	COG0511	ligase activity, forming carbon-carbon bonds
K5706_RS00975	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K5706_RS00980	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K5706_RS00995	COG2814	Major facilitator Superfamily
K5706_RS01000	COG0784	Response regulator, receiver
K5706_RS01000	COG2205	protein histidine kinase activity
K5706_RS01000	COG2198	Histidine kinase
K5706_RS01010	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K5706_RS01020	COG2095	MarC family integral membrane protein
K5706_RS01030	COG4232	protein-disulfide reductase activity
K5706_RS01035	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
K5706_RS01040	COG1027	Aspartate ammonia-lyase
K5706_RS01045	COG3030	protein affecting phage T7 exclusion by the F plasmid
K5706_RS01050	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
K5706_RS01055	COG2205	protein histidine kinase activity
K5706_RS01060	COG0745	RESPONSE REGULATOR receiver
K5706_RS01065	COG3678	ATP-independent chaperone mediated protein folding
K5706_RS01080	COG0534	Mate efflux family protein
K5706_RS01105	COG1509	lysine 2,3-aminomutase activity
K5706_RS01125	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K5706_RS01130	COG1053	succinate dehydrogenase
K5706_RS01155	COG4942	peptidase
K5706_RS01160	COG1045	serine acetyltransferase
K5706_RS01175	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K5706_RS01180	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
K5706_RS01195	COG0471	metal ion transport
K5706_RS01210	COG1162	GTPase activity
K5706_RS01215	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
K5706_RS01290	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K5706_RS01295	COG0802	atpase or kinase
K5706_RS01305	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K5706_RS01310	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K5706_RS01320	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K5706_RS01325	COG0330	HflC and HflK could
K5706_RS01330	COG0330	HflC and HflK could
K5706_RS01335	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
K5706_RS01340	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K5706_RS01345	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
K5706_RS01350	COG1017	nitric oxide dioxygenase activity
K5706_RS01350	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K5706_RS01360	COG0557	exoribonuclease II activity
K5706_RS01365	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K5706_RS01370	COG0546	phosphoglycolate phosphatase activity
K5706_RS01385	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K5706_RS01405	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K5706_RS01410	COG3954	Phosphoribulokinase
K5706_RS01415	COG3089	Belongs to the UPF0270 family
K5706_RS01420	COG0429	hydrolase of the alpha beta-hydrolase fold
K5706_RS01430	COG0488	(ABC) transporter
K5706_RS01435	COG2249	NAD(P)H dehydrogenase (quinone) activity
K5706_RS01450	COG1047	Peptidyl-prolyl cis-trans
K5706_RS01455	COG1446	asparaginase
K5706_RS01470	COG0545	Peptidyl-prolyl cis-trans isomerase
K5706_RS01475	COG2964	Protein conserved in bacteria
K5706_RS01480	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
K5706_RS01485	COG2923	Belongs to the DsrF TusC family
K5706_RS01505	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K5706_RS01525	COG0281	malic enzyme
K5706_RS01535	COG0626	cystathionine gamma-synthase activity
K5706_RS01540	COG0460	homoserine dehydrogenase
K5706_RS01540	COG0527	aspartate kinase activity
K5706_RS01545	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K5706_RS01555	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
K5706_RS01565	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
K5706_RS01580	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
K5706_RS01580	COG0165	Argininosuccinate lyase
K5706_RS01590	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K5706_RS01590	COG0678	peroxiredoxin activity
K5706_RS01600	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
K5706_RS01645	COG0338	D12 class N6 adenine-specific DNA methyltransferase
K5706_RS01650	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K5706_RS01655	COG0360	Binds together with S18 to 16S ribosomal RNA
K5706_RS01660	COG2965	DNA replication, synthesis of RNA primer
K5706_RS01670	COG0359	binds to the 23S rRNA
K5706_RS01685	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K5706_RS01695	COG0432	Pfam Uncharacterised protein family UPF0047
K5706_RS01710	COG0735	belongs to the Fur family
K5706_RS01715	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K5706_RS01735	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K5706_RS01805	COG1410	methionine synthase
K5706_RS01805	COG0646	methionine synthase
K5706_RS01810	COG0527	aspartate kinase activity
K5706_RS01815	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
K5706_RS01825	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K5706_RS01835	COG2197	response regulator
K5706_RS01840	COG0629	single-stranded DNA binding
K5706_RS01845	COG2199	diguanylate cyclase activity
K5706_RS01845	COG2200	EAL domain
K5706_RS01865	COG1450	Type ii and iii secretion system protein
K5706_RS01870	COG3267	Type II secretory pathway component ExeA
K5706_RS01870	COG3409	Peptidoglycan-binding domain 1 protein
K5706_RS01880	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K5706_RS01930	COG1077	Cell shape determining protein MreB Mrl
K5706_RS01935	COG1792	Involved in formation and maintenance of cell shape
K5706_RS01940	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
K5706_RS01945	COG0424	maF-like protein
K5706_RS01955	COG3164	Protein of unknown function
K5706_RS01960	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K5706_RS01965	COG0312	modulator of DNA gyrase
K5706_RS01970	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
K5706_RS01975	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K5706_RS01980	COG0564	pseudouridine synthase activity
K5706_RS01985	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K5706_RS01990	COG3028	Belongs to the UPF0307 family
K5706_RS01995	COG0312	modulator of DNA gyrase
K5706_RS02000	COG2239	Acts as a magnesium transporter
K5706_RS02005	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K5706_RS02015	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K5706_RS02020	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K5706_RS02030	COG1137	ATPase activity
K5706_RS02035	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
K5706_RS02045	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
K5706_RS02045	COG0517	IMP dehydrogenase activity
K5706_RS02055	COG1127	ABC transporter
K5706_RS02060	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K5706_RS02065	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K5706_RS02070	COG2854	intermembrane phospholipid transfer
K5706_RS02080	COG5007	Belongs to the BolA IbaG family
K5706_RS02090	COG0204	Acyl-transferase
K5706_RS02095	COG0251	oxidation-reduction process
K5706_RS02135	COG0456	acetyltransferase
K5706_RS02145	COG0525	valine-tRNA ligase activity
K5706_RS02150	COG2927	DNA polymerase III (CHI subunit)
K5706_RS02155	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K5706_RS02160	COG0795	lipopolysaccharide-transporting ATPase activity
K5706_RS02165	COG0795	lipopolysaccharide-transporting ATPase activity
K5706_RS02185	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K5706_RS02185	COG3153	acetyltransferase
K5706_RS02225	COG1012	belongs to the aldehyde dehydrogenase family
K5706_RS02300	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
K5706_RS02325	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K5706_RS02330	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
K5706_RS02345	COG0762	integral membrane protein
K5706_RS02350	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K5706_RS02355	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K5706_RS02370	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K5706_RS02375	COG1678	Uncharacterized ACR, COG1678
K5706_RS02380	COG0189	ligase activity
K5706_RS02385	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K5706_RS02390	COG2356	endonuclease I
K5706_RS02415	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K5706_RS02430	COG0126	phosphoglycerate kinase activity
K5706_RS02435	COG0191	fructose-bisphosphate aldolase activity
K5706_RS02440	COG0668	transmembrane transport
K5706_RS02450	COG1279	arginine transmembrane transporter activity
K5706_RS02455	COG0583	DNA-binding transcription factor activity
K5706_RS02465	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K5706_RS02475	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K5706_RS02485	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
K5706_RS02490	COG3079	Belongs to the UPF0149 family
K5706_RS02495	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K5706_RS02500	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K5706_RS02520	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
K5706_RS02525	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
K5706_RS02530	COG1595	DNA-templated transcription, initiation
K5706_RS02545	COG3086	response to oxidative stress
K5706_RS02565	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K5706_RS02570	COG1381	Involved in DNA repair and RecF pathway recombination
K5706_RS02575	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
K5706_RS02595	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K5706_RS02600	COG3956	TIGRFAM MazG family protein
K5706_RS02610	COG0148	phosphopyruvate hydratase activity
K5706_RS02620	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
K5706_RS02625	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
K5706_RS02650	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K5706_RS02660	COG1546	Belongs to the CinA family
K5706_RS02665	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K5706_RS02680	COG0527	aspartate kinase activity
K5706_RS02770	COG3630	sodium ion export across plasma membrane
K5706_RS02775	COG5016	pyruvate
K5706_RS02775	COG0511	ligase activity, forming carbon-carbon bonds
K5706_RS02780	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
K5706_RS02790	COG1238	metal cluster binding
K5706_RS02795	COG0612	Peptidase, M16
K5706_RS02810	COG1854	S-ribosylhomocysteine lyase activity
K5706_RS02815	COG4536	flavin adenine dinucleotide binding
K5706_RS02820	COG4137	Cytochrome C assembly protein
K5706_RS02825	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K5706_RS02850	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
K5706_RS02855	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
K5706_RS02860	COG0237	dephospho-CoA kinase activity
K5706_RS02870	COG1459	type II secretion system
K5706_RS02875	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K5706_RS02885	COG0157	Belongs to the NadC ModD family
K5706_RS02895	COG2186	Transcriptional regulator
K5706_RS02900	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
K5706_RS02905	COG0508	dehydrogenase complex catalyzes the overall conversion of
K5706_RS02910	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K5706_RS02925	COG0288	reversible hydration of carbon dioxide
K5706_RS02930	COG0659	secondary active sulfate transmembrane transporter activity
K5706_RS02935	COG1131	(ABC) transporter
K5706_RS02940	COG0842	Transport permease protein
K5706_RS02955	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K5706_RS02965	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K5706_RS02975	COG1489	DNA binding
K5706_RS02980	COG1643	Atp-dependent helicase
K5706_RS02985	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K5706_RS02990	COG1752	Esterase of the alpha-beta hydrolase superfamily
K5706_RS03000	COG1929	Belongs to the glycerate kinase type-1 family
K5706_RS03005	COG2610	gluconate transmembrane transporter activity
K5706_RS03010	COG3835	regulator
K5706_RS03025	COG0004	ammonium transporteR
K5706_RS03030	COG1840	ABC-type Fe3 transport system, periplasmic component
K5706_RS03040	COG3842	ATPase activity
K5706_RS03045	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K5706_RS03060	COG2971	BadF BadG BcrA BcrD
K5706_RS03070	COG4608	Belongs to the ABC transporter superfamily
K5706_RS03075	COG0444	Belongs to the ABC transporter superfamily
K5706_RS03080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K5706_RS03090	COG0747	negative chemotaxis
K5706_RS03095	COG0784	Response regulator, receiver
K5706_RS03095	COG2205	protein histidine kinase activity
K5706_RS03105	COG0628	permease
K5706_RS03110	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
K5706_RS03115	COG0316	Belongs to the HesB IscA family
K5706_RS03130	COG0739	heme binding
K5706_RS03135	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K5706_RS03145	COG2027	D-alanyl-D-alanine carboxypeptidase
K5706_RS03150	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K5706_RS03155	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K5706_RS03160	COG1534	Rna-binding protein
K5706_RS03165	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
K5706_RS03170	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K5706_RS03175	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
K5706_RS03180	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K5706_RS03185	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K5706_RS03200	COG0779	Required for maturation of 30S ribosomal subunits
K5706_RS03205	COG0195	Participates in both transcription termination and antitermination
K5706_RS03225	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K5706_RS03230	COG1185	polyribonucleotide nucleotidyltransferase activity
K5706_RS03240	COG1846	Transcriptional regulator
K5706_RS03245	COG0534	Mate efflux family protein
K5706_RS03250	COG0826	peptidase U32
K5706_RS03255	COG0826	peptidase U32
K5706_RS03265	COG3154	lipid carrier protein
K5706_RS03270	COG3153	acetyltransferase
K5706_RS03290	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
K5706_RS03300	COG0084	hydrolase, TatD family'
K5706_RS03305	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K5706_RS03315	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
K5706_RS03325	COG0813	purine-nucleoside phosphorylase activity
K5706_RS03335	COG0560	Phosphoserine phosphatase
K5706_RS03345	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
K5706_RS03350	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K5706_RS03355	COG1022	Amp-dependent synthetase and ligase
K5706_RS03365	COG0583	DNA-binding transcription factor activity
K5706_RS03370	COG1609	Transcriptional regulator
K5706_RS03375	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K5706_RS03390	COG2017	converts alpha-aldose to the beta-anomer
K5706_RS03395	COG1609	Transcriptional regulator
K5706_RS03415	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
K5706_RS03430	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
K5706_RS03435	COG3257	ureidoglycine aminohydrolase activity
K5706_RS03440	COG0549	Belongs to the carbamate kinase family
K5706_RS03445	COG0583	DNA-binding transcription factor activity
K5706_RS03450	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
K5706_RS03455	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
K5706_RS03465	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
K5706_RS03470	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K5706_RS03480	COG1301	dicarboxylic acid transport
K5706_RS03485	COG1953	Uracil, thiamine, allantoin
K5706_RS03500	COG3960	tartronate-semialdehyde synthase activity
K5706_RS03505	COG3622	Belongs to the hyi family
K5706_RS03510	COG2084	Dehydrogenase
K5706_RS03515	COG1929	Belongs to the glycerate kinase type-1 family
K5706_RS03520	COG2171	N-acyltransferase activity
K5706_RS03535	COG3141	response to X-ray
K5706_RS03550	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
K5706_RS03555	COG1074	ATP-dependent DNA helicase activity
K5706_RS03560	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K5706_RS03565	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
K5706_RS03565	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K5706_RS03575	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
K5706_RS03580	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
K5706_RS03585	COG2166	iron-sulfur cluster assembly
K5706_RS03590	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K5706_RS03595	COG0693	protein deglycase activity
K5706_RS03600	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K5706_RS03605	COG3248	Nucleoside-binding outer membrane protein
K5706_RS03620	COG1595	DNA-templated transcription, initiation
K5706_RS03660	COG0271	Belongs to the BolA IbaG family
K5706_RS03685	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K5706_RS03695	COG1477	protein flavinylation
K5706_RS03710	COG0840	transmembrane signaling receptor activity
K5706_RS03715	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K5706_RS03720	COG0514	ATP-dependent DNA helicase (RecQ)
K5706_RS03725	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K5706_RS03735	COG0733	neurotransmitter:sodium symporter activity
K5706_RS03760	COG1720	tRNA m6t6A37 methyltransferase activity
K5706_RS03765	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
K5706_RS03795	COG3098	single-species biofilm formation
K5706_RS03800	COG0564	pseudouridine synthase activity
K5706_RS03815	COG0024	Methionine aminopeptidase
K5706_RS03825	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K5706_RS03840	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K5706_RS03845	COG0575	Belongs to the CDS family
K5706_RS03855	COG0750	zinc metalloprotease
K5706_RS03865	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
K5706_RS03870	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K5706_RS03895	COG0587	DNA-directed DNA polymerase activity
K5706_RS03915	COG0347	Belongs to the P(II) protein family
K5706_RS03930	COG1388	LysM domain
K5706_RS03930	COG0741	lytic transglycosylase activity
K5706_RS03935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K5706_RS03940	COG2226	methyltransferase
K5706_RS03950	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K5706_RS03965	COG1960	acyl-CoA dehydrogenase activity
K5706_RS03970	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
K5706_RS03975	COG0121	glutamine amidotransferase
K5706_RS03980	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K5706_RS03985	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K5706_RS03990	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K5706_RS03995	COG2233	PERMEase
K5706_RS04015	COG1393	Belongs to the ArsC family
K5706_RS04020	COG4783	chaperone-mediated protein folding
K5706_RS04035	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K5706_RS04040	COG2716	regulation of RNA biosynthetic process
K5706_RS04045	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K5706_RS04050	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
K5706_RS04070	COG1393	Belongs to the ArsC family
K5706_RS04190	COG2837	iron assimilation
K5706_RS04195	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K5706_RS04200	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K5706_RS04205	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K5706_RS04210	COG1334	flagellar protein FlaG
K5706_RS04215	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
K5706_RS04225	COG1516	flagellar protein fliS
K5706_RS04245	COG1677	Flagellar hook-basal body complex protein FliE
K5706_RS04255	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K5706_RS04305	COG1987	bacterial-type flagellum assembly
K5706_RS04310	COG1684	flagellar biosynthetic protein fliR
K5706_RS04345	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
K5706_RS04350	COG2198	Histidine kinase
K5706_RS04350	COG0784	Response regulator, receiver
K5706_RS04350	COG0643	Histidine kinase
K5706_RS04355	COG2201	protein-glutamate methylesterase activity
K5706_RS04360	COG1192	Involved in chromosome partitioning
K5706_RS04370	COG0835	chemotaxis
K5706_RS04380	COG4133	protoheme IX ABC transporter activity
K5706_RS04390	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K5706_RS04405	COG1138	Cytochrome C-type biogenesis protein
K5706_RS04410	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K5706_RS04420	COG3088	subunit of a heme lyase
K5706_RS04420	COG4235	cytochrome complex assembly
K5706_RS04425	COG2853	Lipoprotein
K5706_RS04450	COG0183	Belongs to the thiolase family
K5706_RS04455	COG1024	Enoyl-CoA hydratase
K5706_RS04455	COG1250	3-hydroxyacyl-CoA dehydrogenase
K5706_RS04470	COG2062	phosphohistidine phosphatase, SixA
K5706_RS04475	COG2840	Smr protein MutS2
K5706_RS04480	COG2890	protein-(glutamine-N5) methyltransferase activity
K5706_RS04485	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K5706_RS04490	COG2860	membrane
K5706_RS04515	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K5706_RS04520	COG0583	DNA-binding transcription factor activity
K5706_RS04525	COG4771	TonB-dependent receptor
K5706_RS04545	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5706_RS04545	COG1263	PTS System
K5706_RS04555	COG1621	beta-fructofuranosidase activity
K5706_RS04560	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K5706_RS04565	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K5706_RS04585	COG0285	dihydrofolate synthase activity
K5706_RS04590	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
K5706_RS04595	COG1286	toxin biosynthetic process
K5706_RS04600	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
K5706_RS04605	COG0583	DNA-binding transcription factor activity
K5706_RS04610	COG0745	RESPONSE REGULATOR receiver
K5706_RS04615	COG2832	Protein of unknown function (DUF454)
K5706_RS04625	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
K5706_RS04630	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
K5706_RS04635	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K5706_RS04640	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K5706_RS04650	COG2983	Belongs to the UPF0260 family
K5706_RS04655	COG2261	transglycosylase associated protein
K5706_RS04665	COG0076	glutamate decarboxylase activity
K5706_RS04670	COG0668	transmembrane transport
K5706_RS04685	COG1522	sequence-specific DNA binding
K5706_RS04690	COG1946	Acyl-CoA thioesterase
K5706_RS04695	COG3126	Type III secretion system lipoprotein chaperone (YscW)
K5706_RS04710	COG3706	GGDEF domain
K5706_RS04720	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K5706_RS04725	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
K5706_RS04730	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
K5706_RS04735	COG0517	IMP dehydrogenase activity
K5706_RS04735	COG0516	GMP reductase activity
K5706_RS04765	COG0537	adenosine 5'-monophosphoramidase activity
K5706_RS04795	COG1252	NADH dehydrogenase
K5706_RS04810	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K5706_RS04820	COG4591	ABC-type transport system involved in lipoprotein release permease component
K5706_RS04825	COG1136	(ABC) transporter
K5706_RS04830	COG4591	ABC-type transport system involved in lipoprotein release permease component
K5706_RS04845	COG1132	(ABC) transporter
K5706_RS04870	COG2719	SpoVR family
K5706_RS04875	COG2718	Belongs to the UPF0229 family
K5706_RS04880	COG2766	serine protein kinase
K5706_RS04895	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K5706_RS04905	COG1882	Formate acetyltransferase
K5706_RS04940	COG0708	Exodeoxyribonuclease III
K5706_RS04950	COG3923	Primosomal replication protein n
K5706_RS04955	COG0730	response to heat
K5706_RS04960	COG1199	ATP-dependent helicase activity
K5706_RS04970	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
K5706_RS04975	COG1187	pseudouridine synthase activity
K5706_RS04985	COG1278	Cold shock
K5706_RS04995	COG0542	response to heat
K5706_RS05000	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K5706_RS05005	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
K5706_RS05030	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K5706_RS05035	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K5706_RS05040	COG0297	glycogen (starch) synthase activity
K5706_RS05060	COG3070	regulator of competence-specific genes
K5706_RS05070	COG3381	protein complex oligomerization
K5706_RS05075	COG0745	RESPONSE REGULATOR receiver
K5706_RS05080	COG1434	Gram-negative-bacterium-type cell wall biogenesis
K5706_RS05085	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K5706_RS05090	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
K5706_RS05095	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
K5706_RS05100	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K5706_RS05120	COG4067	protein conserved in archaea
K5706_RS05120	COG0189	ligase activity
K5706_RS05125	COG0500	methyltransferase
K5706_RS05130	COG4106	trans-aconitate 2-methyltransferase activity
K5706_RS05135	COG1801	Protein of unknown function DUF72
K5706_RS05140	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K5706_RS05145	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
K5706_RS05150	COG0632	four-way junction helicase activity
K5706_RS05160	COG1271	oxidase subunit
K5706_RS05165	COG1294	oxidase, subunit
K5706_RS05170	COG4890	Cyd operon protein YbgT
K5706_RS05180	COG0824	Thioesterase
K5706_RS05185	COG0811	peptide transport
K5706_RS05200	COG0823	Involved in the tonB-independent uptake of proteins
K5706_RS05205	COG2885	chlorophyll binding
K5706_RS05210	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
K5706_RS05215	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
K5706_RS05230	COG5002	protein histidine kinase activity
K5706_RS05230	COG0784	Response regulator, receiver
K5706_RS05260	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
K5706_RS05265	COG1397	ADP-ribosylglycohydrolase
K5706_RS05340	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K5706_RS05345	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K5706_RS05370	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K5706_RS05385	COG0697	spore germination
K5706_RS05390	COG2176	DNA-directed DNA polymerase activity
K5706_RS05395	COG0517	IMP dehydrogenase activity
K5706_RS05400	COG3293	Transposase
K5706_RS05405	COG2186	Transcriptional regulator
K5706_RS05410	COG2186	Transcriptional regulator
K5706_RS05415	COG0534	Mate efflux family protein
K5706_RS05435	COG1917	Cupin 2, conserved barrel domain protein
K5706_RS05440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K5706_RS05445	COG0800	Aldolase
K5706_RS05455	COG3293	Transposase
K5706_RS05465	COG2084	Dehydrogenase
K5706_RS05480	COG0583	DNA-binding transcription factor activity
K5706_RS05490	COG0686	Belongs to the AlaDH PNT family
K5706_RS05505	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
K5706_RS05510	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K5706_RS05520	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K5706_RS05535	COG0156	8-amino-7-oxononanoate synthase activity
K5706_RS05575	COG0300	oxidoreductase activity
K5706_RS05590	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K5706_RS05600	COG2268	Band 7 protein
K5706_RS05610	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K5706_RS05620	COG0482	sulfurtransferase activity
K5706_RS05630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K5706_RS05635	COG2916	Histone family protein nucleoid-structuring protein H-NS
K5706_RS05640	COG1757	Na H antiporter
K5706_RS05650	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K5706_RS05655	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K5706_RS05660	COG0131	Imidazoleglycerol-phosphate dehydratase
K5706_RS05660	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
K5706_RS05665	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
K5706_RS05670	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K5706_RS05680	COG0140	phosphoribosyl-ATP diphosphatase activity
K5706_RS05680	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K5706_RS05685	COG3012	SEC-C Motif Domain Protein
K5706_RS05690	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
K5706_RS05695	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K5706_RS05700	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K5706_RS05705	COG0215	cysteine-tRNA ligase activity
K5706_RS05710	COG1435	thymidine kinase activity
K5706_RS05715	COG1434	Gram-negative-bacterium-type cell wall biogenesis
K5706_RS05740	COG2116	formate transmembrane transporter activity
K5706_RS05750	COG0390	transport system, permease component
K5706_RS05755	COG4459	periplasmic nitrate reductase
K5706_RS05760	COG3005	denitrification pathway
K5706_RS05765	COG0243	molybdopterin cofactor binding
K5706_RS05780	COG1227	inorganic diphosphatase activity
K5706_RS05790	COG4172	Belongs to the ABC transporter superfamily
K5706_RS05800	COG4171	peptide transport system, permease
K5706_RS05805	COG4168	peptide transport system, permease
K5706_RS05815	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
K5706_RS05820	COG1842	Phage shock protein A
K5706_RS05840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K5706_RS05850	COG2818	Glycosylase
K5706_RS05855	COG0626	cystathionine gamma-synthase activity
K5706_RS05865	COG0733	neurotransmitter:sodium symporter activity
K5706_RS05875	COG0564	pseudouridine synthase activity
K5706_RS05885	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K5706_RS05890	COG1151	hydroxylamine reductase activity
K5706_RS05895	COG3604	Transcriptional regulator
K5706_RS05905	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K5706_RS05910	COG4136	ATPase activity
K5706_RS05915	COG4135	transport system, permease component
K5706_RS05920	COG4134	Bacterial extracellular solute-binding protein
K5706_RS05925	COG0398	Pfam SNARE associated Golgi protein
K5706_RS05935	COG0493	'glutamate synthase
K5706_RS05960	COG3313	Fe-S protein
K5706_RS05970	COG0737	Belongs to the 5'-nucleotidase family
K5706_RS05995	COG1061	Type III restriction enzyme res subunit
K5706_RS06000	COG1187	pseudouridine synthase activity
K5706_RS06005	COG2814	Major facilitator Superfamily
K5706_RS06015	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K5706_RS06025	COG1609	Transcriptional regulator
K5706_RS06030	COG0702	epimerase
K5706_RS06040	COG4181	ATPase activity
K5706_RS06070	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K5706_RS06080	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K5706_RS06090	COG1737	Transcriptional regulator
K5706_RS06095	COG0076	glutamate decarboxylase activity
K5706_RS06105	COG2431	L-lysine efflux transmembrane transporter activity
K5706_RS06125	COG3070	regulator of competence-specific genes
K5706_RS06140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K5706_RS06140	COG4191	Histidine kinase
K5706_RS06150	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
K5706_RS06160	COG3706	GGDEF domain
K5706_RS06170	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
K5706_RS06175	COG4988	ABC transporter
K5706_RS06180	COG0492	ferredoxin-NADP+ reductase activity
K5706_RS06190	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K5706_RS06200	COG3706	GGDEF domain
K5706_RS06205	COG0471	metal ion transport
K5706_RS06210	COG2949	membrane
K5706_RS06220	COG1643	Atp-dependent helicase
K5706_RS06230	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K5706_RS06265	COG0247	lactate metabolic process
K5706_RS06265	COG0277	FAD linked oxidase domain protein
K5706_RS06280	COG2986	histidine ammonia-lyase
K5706_RS06285	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
K5706_RS06290	COG0010	Belongs to the arginase family
K5706_RS06315	COG1960	acyl-CoA dehydrogenase activity
K5706_RS06320	COG3706	GGDEF domain
K5706_RS06325	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K5706_RS06335	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K5706_RS06345	COG0393	Putative heavy-metal-binding
K5706_RS06360	COG0072	phenylalanine-tRNA ligase activity
K5706_RS06360	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K5706_RS06390	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
K5706_RS06395	COG1643	Atp-dependent helicase
K5706_RS06405	COG0534	Mate efflux family protein
K5706_RS06410	COG2113	Glycine betaine
K5706_RS06415	COG4176	ABC-type proline glycine betaine transport system permease component
K5706_RS06435	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K5706_RS06440	COG0456	acetyltransferase
K5706_RS06445	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K5706_RS06450	COG0662	Cupin 2, conserved barrel domain protein
K5706_RS06455	COG0527	aspartate kinase activity
K5706_RS06460	COG0583	DNA-binding transcription factor activity
K5706_RS06465	COG0702	epimerase
K5706_RS06480	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K5706_RS06495	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K5706_RS06500	COG0363	glucosamine-6-phosphate deaminase activity
K5706_RS06505	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
K5706_RS06580	COG3284	Transcriptional regulator
K5706_RS06585	COG1012	belongs to the aldehyde dehydrogenase family
K5706_RS06595	COG2358	TRAP transporter, solute receptor (TAXI family
K5706_RS06600	COG0730	response to heat
K5706_RS06605	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
K5706_RS06610	COG2186	Transcriptional regulator
K5706_RS06615	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
K5706_RS06620	COG0372	Belongs to the citrate synthase family
K5706_RS06630	COG2828	Protein conserved in bacteria
K5706_RS06650	COG0561	phosphatase activity
K5706_RS06655	COG0602	queuosine metabolic process
K5706_RS06700	COG1254	Belongs to the acylphosphatase family
K5706_RS06705	COG2920	part of a sulfur-relay system
K5706_RS06710	COG0670	Belongs to the BI1 family
K5706_RS06715	COG1126	abc transporter atp-binding protein
K5706_RS06720	COG0765	amino acid transport
K5706_RS06725	COG4597	amino acid ABC transporter
K5706_RS06730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K5706_RS06745	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K5706_RS06770	COG3008	intermembrane lipid transfer
K5706_RS06775	COG2995	paraquat-inducible protein a
K5706_RS06780	COG1132	(ABC) transporter
K5706_RS06790	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
K5706_RS06805	COG0308	aminopeptidase N
K5706_RS06815	COG2902	Dehydrogenase
K5706_RS06820	COG0167	dihydroorotate dehydrogenase activity
K5706_RS06840	COG0488	(ABC) transporter
K5706_RS06855	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K5706_RS06860	COG1067	ATP-dependent peptidase activity
K5706_RS06865	COG3120	sequence-specific DNA binding
K5706_RS06880	COG2205	protein histidine kinase activity
K5706_RS06880	COG0784	Response regulator, receiver
K5706_RS06895	COG3278	Belongs to the heme-copper respiratory oxidase family
K5706_RS06910	COG2010	Cytochrome c
K5706_RS06935	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K5706_RS06940	COG0589	response to stress
K5706_RS06965	COG3842	ATPase activity
K5706_RS06975	COG1177	transmembrane transport
K5706_RS06985	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K5706_RS06990	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K5706_RS07005	COG0437	4 iron, 4 sulfur cluster binding
K5706_RS07010	COG3383	formate dehydrogenase (NAD+) activity
K5706_RS07010	COG0243	molybdopterin cofactor binding
K5706_RS07020	COG3381	protein complex oligomerization
K5706_RS07040	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K5706_RS07045	COG0488	(ABC) transporter
K5706_RS07060	COG4191	Histidine kinase
K5706_RS07080	COG3842	ATPase activity
K5706_RS07090	COG0303	'Molybdopterin
K5706_RS07100	COG1940	carbohydrate kinase activity
K5706_RS07105	COG3148	PFAM DTW domain containing protein
K5706_RS07120	COG0791	NLP P60 protein
K5706_RS07130	COG3706	GGDEF domain
K5706_RS07135	COG2201	protein-glutamate methylesterase activity
K5706_RS07140	COG3001	Fructosamine kinase
K5706_RS07150	COG0307	riboflavin synthase, alpha
K5706_RS07155	COG0534	Mate efflux family protein
K5706_RS07175	COG3064	Membrane
K5706_RS07180	COG0110	maltose O-acetyltransferase activity
K5706_RS07195	COG0697	spore germination
K5706_RS07200	COG3247	response to pH
K5706_RS07205	COG0668	transmembrane transport
K5706_RS07210	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
K5706_RS07225	COG2205	protein histidine kinase activity
K5706_RS07225	COG0784	Response regulator, receiver
K5706_RS07285	COG0110	maltose O-acetyltransferase activity
K5706_RS07290	COG0438	transferase activity, transferring glycosyl groups
K5706_RS07300	COG0438	transferase activity, transferring glycosyl groups
K5706_RS07310	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K5706_RS07345	COG0625	glutathione transferase activity
K5706_RS07355	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
K5706_RS07405	COG2195	Cleaves the N-terminal amino acid of tripeptides
K5706_RS07425	COG0583	DNA-binding transcription factor activity
K5706_RS07430	COG2814	Major facilitator Superfamily
K5706_RS07440	COG0583	DNA-binding transcription factor activity
K5706_RS07495	COG1175	transmembrane transport
K5706_RS07500	COG1176	ABC-type spermidine putrescine transport system, permease component I
K5706_RS07505	COG3842	ATPase activity
K5706_RS07510	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K5706_RS07515	COG2423	ornithine cyclodeaminase activity
K5706_RS07525	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K5706_RS07530	COG3938	Belongs to the proline racemase family
K5706_RS07560	COG0784	Response regulator, receiver
K5706_RS07560	COG2205	protein histidine kinase activity
K5706_RS07570	COG1451	nucleotide metabolic process
K5706_RS07580	COG0583	DNA-binding transcription factor activity
K5706_RS07615	COG1115	amino acid carrier protein
K5706_RS07620	COG1280	lysine exporter protein (LysE YggA)
K5706_RS07625	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
K5706_RS07630	COG1560	Kdo2-lipid A biosynthetic process
K5706_RS07635	COG1280	lysine exporter protein (LysE YggA)
K5706_RS07640	COG0531	amino acid
K5706_RS07660	COG3063	Type IV pilus biogenesis stability protein PilW
K5706_RS07670	COG4139	cobalamin transport
K5706_RS07695	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
K5706_RS07705	COG0702	epimerase
K5706_RS07715	COG0784	Response regulator, receiver
K5706_RS07715	COG2205	protein histidine kinase activity
K5706_RS07785	COG0784	Response regulator, receiver
K5706_RS07785	COG2205	protein histidine kinase activity
K5706_RS07790	COG2188	Transcriptional regulator
K5706_RS07795	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K5706_RS07795	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K5706_RS07795	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K5706_RS07800	COG0383	alpha-mannosidase activity
K5706_RS07805	COG1482	cell wall glycoprotein biosynthetic process
K5706_RS07820	COG2925	Exonuclease
K5706_RS07835	COG0295	cytidine deaminase activity
K5706_RS07855	COG0776	regulation of translation
K5706_RS07865	COG3706	GGDEF domain
K5706_RS07875	COG0443	Heat shock 70 kDa protein
K5706_RS07880	COG0443	Heat shock 70 kDa protein
K5706_RS07895	COG1132	(ABC) transporter
K5706_RS07900	COG1132	(ABC) transporter
K5706_RS07915	COG3437	response regulator, receiver
K5706_RS07920	COG0814	amino acid
K5706_RS07935	COG0861	Integral membrane protein TerC family
K5706_RS07945	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K5706_RS07950	COG1328	CTP reductase activity
K5706_RS07955	COG1280	lysine exporter protein (LysE YggA)
K5706_RS07965	COG5001	Diguanylate cyclase
K5706_RS07975	COG4191	Histidine kinase
K5706_RS07975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K5706_RS07980	COG0471	metal ion transport
K5706_RS07990	COG0456	acetyltransferase
K5706_RS08055	COG1028	Short-chain dehydrogenase reductase Sdr
K5706_RS08135	COG3293	Transposase
K5706_RS08160	COG2944	sequence-specific DNA binding
K5706_RS08165	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
K5706_RS08245	COG3293	Transposase
K5706_RS08270	COG0494	nUDIX hydrolase
K5706_RS08395	COG0456	acetyltransferase
K5706_RS08515	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K5706_RS08530	COG3106	COG3106 Predicted ATPase
K5706_RS08545	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K5706_RS08550	COG0494	nUDIX hydrolase
K5706_RS08555	COG0814	amino acid
K5706_RS08560	COG1760	l-serine dehydratase
K5706_RS08570	COG0720	synthase
K5706_RS08575	COG0017	Asparaginyl-tRNA synthetase
K5706_RS08590	COG1448	Aminotransferase
K5706_RS08680	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K5706_RS08700	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K5706_RS08710	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K5706_RS08740	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
K5706_RS08755	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K5706_RS08760	COG3108	Peptidase M15
K5706_RS08765	COG2989	Protein conserved in bacteria
K5706_RS08770	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K5706_RS08790	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K5706_RS08795	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K5706_RS08800	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K5706_RS08820	COG0287	Prephenate dehydrogenase
K5706_RS08825	COG0019	diaminopimelate decarboxylase activity
K5706_RS08865	COG0322	excinuclease ABC activity
K5706_RS08870	COG2197	response regulator
K5706_RS08875	COG0417	DNA replication proofreading
K5706_RS08895	COG1187	pseudouridine synthase activity
K5706_RS08900	COG0009	L-threonylcarbamoyladenylate synthase
K5706_RS08905	COG0613	PHP domain protein
K5706_RS08915	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K5706_RS08920	COG0512	Glutamine amidotransferase of anthranilate synthase
K5706_RS08930	COG0135	phosphoribosylanthranilate isomerase activity
K5706_RS08930	COG0134	indole-3-glycerol-phosphate synthase activity
K5706_RS08940	COG0159	tryptophan synthase activity
K5706_RS08945	COG1301	dicarboxylic acid transport
K5706_RS08955	COG1607	acyl-coa hydrolase
K5706_RS08960	COG2350	Protein conserved in bacteria
K5706_RS08970	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
K5706_RS08975	COG0583	DNA-binding transcription factor activity
K5706_RS08995	COG1032	radical SAM domain protein
K5706_RS09000	COG0446	pyridine nucleotide-disulphide oxidoreductase
K5706_RS09015	COG2964	Protein conserved in bacteria
K5706_RS09020	COG0840	transmembrane signaling receptor activity
K5706_RS09030	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
K5706_RS09035	COG0463	Glycosyl transferase, family 2
K5706_RS09040	COG0745	RESPONSE REGULATOR receiver
K5706_RS09045	COG3850	Histidine kinase
K5706_RS09045	COG5002	protein histidine kinase activity
K5706_RS09095	COG3118	belongs to the thioredoxin family
K5706_RS09100	COG4232	protein-disulfide reductase activity
K5706_RS09115	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
K5706_RS09120	COG2211	Major facilitator Superfamily
K5706_RS09130	COG4580	involved in the transport of maltose and maltodextrins
K5706_RS09140	COG3250	beta-galactosidase activity
K5706_RS09145	COG1609	Transcriptional regulator
K5706_RS09150	COG2995	paraquat-inducible protein a
K5706_RS09155	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K5706_RS09155	COG3008	intermembrane lipid transfer
K5706_RS09160	COG3009	Protein conserved in bacteria
K5706_RS09180	COG4166	transmembrane transport
K5706_RS09190	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
K5706_RS09195	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
K5706_RS09205	COG0539	negative regulation of cytoplasmic translation
K5706_RS09210	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K5706_RS09215	COG0616	signal peptide processing
K5706_RS09220	COG1028	Short-chain dehydrogenase reductase Sdr
K5706_RS09240	COG0784	Response regulator, receiver
K5706_RS09240	COG0835	chemotaxis
K5706_RS09245	COG1940	carbohydrate kinase activity
K5706_RS09250	COG0469	pyruvate kinase activity
K5706_RS09255	COG4667	esterase of the alpha-beta hydrolase superfamily
K5706_RS09275	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5706_RS09275	COG1263	PTS System
K5706_RS09280	COG0084	hydrolase, TatD family'
K5706_RS09295	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K5706_RS09325	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K5706_RS09335	COG0333	Belongs to the bacterial ribosomal protein bL32 family
K5706_RS09340	COG1399	metal-binding, possibly nucleic acid-binding protein
K5706_RS09345	COG0424	maF-like protein
K5706_RS09350	COG0564	pseudouridine synthase activity
K5706_RS09355	COG1530	ribonuclease E activity
K5706_RS09360	COG0659	secondary active sulfate transmembrane transporter activity
K5706_RS09365	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K5706_RS09370	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
K5706_RS09375	COG2801	Transposase and inactivated derivatives
K5706_RS09380	COG2982	Protein involved in outer membrane biogenesis
K5706_RS09385	COG0572	uridine kinase
K5706_RS09405	COG2186	Transcriptional regulator
K5706_RS09415	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
K5706_RS09420	COG3318	Belongs to the UPF0149 family
K5706_RS09420	COG3012	SEC-C Motif Domain Protein
K5706_RS09425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K5706_RS09440	COG3706	GGDEF domain
K5706_RS09445	COG0366	Alpha amylase catalytic
K5706_RS09450	COG1122	ATPase activity
K5706_RS09455	COG4120	Belongs to the binding-protein-dependent transport system permease family
K5706_RS09475	COG0280	phosphate acetyltransferase
K5706_RS09475	COG0857	belongs to the CobB CobQ family
K5706_RS09480	COG3174	membrane
K5706_RS09485	COG0435	Glutathione S-transferase
K5706_RS09505	COG0444	Belongs to the ABC transporter superfamily
K5706_RS09510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K5706_RS09515	COG0601	transmembrane transport
K5706_RS09525	COG0314	molybdopterin synthase activity
K5706_RS09530	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
K5706_RS09540	COG0521	Mo-molybdopterin cofactor biosynthetic process
K5706_RS09545	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K5706_RS09550	COG0391	Required for morphogenesis under gluconeogenic growth conditions
K5706_RS09555	COG2198	Histidine kinase
K5706_RS09560	COG2204	response regulator
K5706_RS09565	COG0556	nucleotide-excision repair
K5706_RS09575	COG1882	Formate acetyltransferase
K5706_RS09580	COG4657	Part of a membrane complex involved in electron transport
K5706_RS09590	COG4656	Part of a membrane complex involved in electron transport
K5706_RS09595	COG4658	electron transport chain
K5706_RS09600	COG4659	FMN binding
K5706_RS09605	COG4660	Part of a membrane complex involved in electron transport
K5706_RS09610	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K5706_RS09640	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K5706_RS09650	COG2205	protein histidine kinase activity
K5706_RS09650	COG0784	Response regulator, receiver
K5706_RS09680	COG0346	lactoylglutathione lyase activity
K5706_RS09690	COG2885	chlorophyll binding
K5706_RS09700	COG2056	Na+-H+ antiporter family
K5706_RS09720	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K5706_RS09730	COG1621	beta-fructofuranosidase activity
K5706_RS09740	COG3842	ATPase activity
K5706_RS09745	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K5706_RS09750	COG1554	hydrolase, family 65, central catalytic
K5706_RS09755	COG0395	ABC-type sugar transport system, permease component
K5706_RS09760	COG1175	transmembrane transport
K5706_RS09820	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
K5706_RS09840	COG1012	belongs to the aldehyde dehydrogenase family
K5706_RS09840	COG1454	alcohol dehydrogenase
K5706_RS09845	COG2095	MarC family integral membrane protein
K5706_RS09850	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K5706_RS09860	COG1757	Na H antiporter
K5706_RS09885	COG3083	sulfuric ester hydrolase activity
K5706_RS09895	COG0123	including yeast histone deacetylase and acetoin utilization protein
K5706_RS09900	COG4948	Mandelate Racemase Muconate Lactonizing
K5706_RS09910	COG2721	sulfolactate sulfo-lyase activity
K5706_RS09925	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K5706_RS09930	COG0778	Nitroreductase
K5706_RS09935	COG0446	pyridine nucleotide-disulphide oxidoreductase
K5706_RS09935	COG1902	pentaerythritol trinitrate reductase activity
K5706_RS09940	COG0616	signal peptide processing
K5706_RS09945	COG0252	asparaginase activity
K5706_RS09950	COG3139	Protein of unknown function (DUF1315)
K5706_RS09960	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K5706_RS09965	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K5706_RS09975	COG2226	methyltransferase
K5706_RS09995	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K5706_RS10000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K5706_RS10045	COG0477	Major facilitator Superfamily
K5706_RS10050	COG2855	membrane
K5706_RS10060	COG0318	PFAM AMP-dependent synthetase and ligase
K5706_RS10070	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
K5706_RS10085	COG1169	isochorismate synthase
K5706_RS10090	COG0436	Aminotransferase
K5706_RS10095	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
K5706_RS10115	COG1555	photosystem II stabilization
K5706_RS10120	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K5706_RS10125	COG0776	regulation of translation
K5706_RS10130	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K5706_RS10135	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K5706_RS10165	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K5706_RS10170	COG0569	domain protein
K5706_RS10175	COG0513	Belongs to the DEAD box helicase family
K5706_RS10180	COG1253	flavin adenine dinucleotide binding
K5706_RS10195	COG0840	transmembrane signaling receptor activity
K5706_RS10300	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K5706_RS10310	COG2951	lytic endotransglycosylase activity
K5706_RS10325	COG2894	cell division
K5706_RS10330	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
K5706_RS10335	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
K5706_RS10340	COG0318	PFAM AMP-dependent synthetase and ligase
K5706_RS10345	COG0596	Alpha beta hydrolase
K5706_RS10360	COG1214	PFAM Peptidase M22, glycoprotease
K5706_RS10365	COG1199	ATP-dependent helicase activity
K5706_RS10370	COG0788	formyltetrahydrofolate deformylase activity
K5706_RS10375	COG3102	Protein conserved in bacteria
K5706_RS10400	COG1918	ferrous iron import across plasma membrane
K5706_RS10405	COG4977	sequence-specific DNA binding
K5706_RS10410	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
K5706_RS10415	COG1121	(ABC) transporter
K5706_RS10420	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K5706_RS10435	COG0508	dehydrogenase complex catalyzes the overall conversion of
K5706_RS10440	COG0567	Dehydrogenase, E1 component
K5706_RS10445	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K5706_RS10450	COG1053	succinate dehydrogenase
K5706_RS10455	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
K5706_RS10470	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
K5706_RS10480	COG0033	Phosphoglucomutase
K5706_RS10485	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
K5706_RS10490	COG0596	Alpha beta hydrolase
K5706_RS10500	COG0716	FMN binding
K5706_RS10510	COG0735	belongs to the Fur family
K5706_RS10520	COG1263	PTS System
K5706_RS10520	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5706_RS10520	COG2190	(PTS) system
K5706_RS10525	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K5706_RS10530	COG1846	Transcriptional regulator
K5706_RS10530	COG1940	carbohydrate kinase activity
K5706_RS10535	COG4651	solute:proton antiporter activity
K5706_RS10535	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K5706_RS10540	COG0367	asparagine synthase
K5706_RS10550	COG3104	oligopeptide transport
K5706_RS10555	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
K5706_RS10565	COG0326	Molecular chaperone. Has ATPase activity
K5706_RS10570	COG3710	Transcriptional regulator
K5706_RS10590	COG0622	Phosphoesterase
K5706_RS10595	COG1090	epimerase
K5706_RS10600	COG0300	oxidoreductase activity
K5706_RS10605	COG3118	belongs to the thioredoxin family
K5706_RS10610	COG0330	HflC and HflK could
K5706_RS10615	COG1585	Membrane protein implicated in regulation of membrane protease activity
K5706_RS10645	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
K5706_RS10650	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K5706_RS10655	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K5706_RS10660	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K5706_RS10665	COG2190	(PTS) system
K5706_RS10670	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K5706_RS10675	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K5706_RS10690	COG1705	Flagellar rod assembly protein muramidase FlgJ
K5706_RS10690	COG3951	Flagellar rod assembly protein muramidase FlgJ
K5706_RS10695	COG1706	bacterial-type flagellum-dependent cell motility
K5706_RS10700	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
K5706_RS10710	COG4787	bacterial-type flagellum-dependent cell motility
K5706_RS10725	COG1558	bacterial-type flagellum-dependent cell motility
K5706_RS10730	COG1815	bacterial-type flagellum-dependent cell motility
K5706_RS10735	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
K5706_RS10740	COG0784	Response regulator, receiver
K5706_RS10740	COG0835	chemotaxis
K5706_RS10790	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K5706_RS10795	COG2608	mercury ion transmembrane transporter activity
K5706_RS10795	COG2217	Heavy metal translocating P-type atpase
K5706_RS10835	COG2840	Smr protein MutS2
K5706_RS10840	COG1187	pseudouridine synthase activity
K5706_RS10845	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K5706_RS10850	COG0737	Belongs to the 5'-nucleotidase family
K5706_RS10860	COG2912	Transglutaminase-like superfamily
K5706_RS10865	COG3094	Invasion gene expression up-regulator, SirB
K5706_RS10870	COG2890	protein-(glutamine-N5) methyltransferase activity
K5706_RS10875	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K5706_RS10895	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K5706_RS11010	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K5706_RS11015	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K5706_RS11020	COG1702	phosphate starvation-inducible protein PhoH
K5706_RS11030	COG4535	Mg2 and Co2 transporter CorC
K5706_RS11035	COG0815	Transfers the fatty acyl group on membrane lipoproteins
K5706_RS11040	COG2888	peptidyl-tyrosine sulfation
K5706_RS11045	COG0495	leucyl-tRNA aminoacylation
K5706_RS11050	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
K5706_RS11055	COG1466	dna polymerase III delta subunit
K5706_RS11060	COG0799	negative regulation of ribosome biogenesis
K5706_RS11065	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K5706_RS11070	COG0768	penicillin binding
K5706_RS11075	COG0772	Belongs to the SEDS family
K5706_RS11080	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
K5706_RS11085	COG1686	Belongs to the peptidase S11 family
K5706_RS11105	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K5706_RS11110	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K5706_RS11125	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
K5706_RS11130	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K5706_RS11135	COG2011	ABC-type metal ion transport system permease component
K5706_RS11140	COG1464	Belongs to the NlpA lipoprotein family
K5706_RS11145	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
K5706_RS11170	COG1611	Belongs to the LOG family
K5706_RS11175	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K5706_RS11185	COG2363	Small membrane protein
K5706_RS11195	COG0583	DNA-binding transcription factor activity
K5706_RS11200	COG0301	tRNA thio-modification
K5706_RS11200	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K5706_RS11210	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K5706_RS11220	COG0142	geranyltranstransferase activity
K5706_RS11230	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
K5706_RS11235	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
K5706_RS11260	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K5706_RS11260	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K5706_RS11265	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K5706_RS11270	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K5706_RS11285	COG1073	alpha beta
K5706_RS11290	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
K5706_RS11295	COG2252	PERMEase
K5706_RS11305	COG2195	Cleaves the N-terminal amino acid of tripeptides
K5706_RS11325	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K5706_RS11325	COG0047	phosphoribosylformylglycinamidine synthase activity
K5706_RS11335	COG0590	tRNA wobble adenosine to inosine editing
K5706_RS11340	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
K5706_RS11370	COG0484	heat shock protein binding
K5706_RS11380	COG1301	dicarboxylic acid transport
K5706_RS11385	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K5706_RS11395	COG0497	DNA recombination
K5706_RS11400	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K5706_RS11405	COG2914	Belongs to the UPF0125 (RnfH) family
K5706_RS11410	COG2867	negative regulation of translational initiation
K5706_RS11425	COG0582	viral genome integration into host DNA
K5706_RS11440	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
K5706_RS11480	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
K5706_RS11490	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
K5706_RS11585	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K5706_RS11595	COG0583	DNA-binding transcription factor activity
K5706_RS11605	COG1115	amino acid carrier protein
K5706_RS11610	COG1584	GPR1 FUN34 yaaH family protein
K5706_RS11620	COG0516	GMP reductase activity
K5706_RS11620	COG0517	IMP dehydrogenase activity
K5706_RS11645	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K5706_RS11650	COG2976	Protein conserved in bacteria
K5706_RS11655	COG0124	histidyl-tRNA synthetase
K5706_RS11685	COG2975	iron-sulfur cluster assembly
K5706_RS11690	COG0633	Ferredoxin
K5706_RS11705	COG0316	Belongs to the HesB IscA family
K5706_RS11710	COG0822	iron-sulfur transferase activity
K5706_RS11725	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
K5706_RS11730	COG0483	inositol monophosphate 1-phosphatase activity
K5706_RS11735	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K5706_RS11740	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K5706_RS11745	COG1862	Preprotein translocase
K5706_RS11750	COG0343	queuine tRNA-ribosyltransferase activity
K5706_RS11755	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K5706_RS11765	COG0517	IMP dehydrogenase activity
K5706_RS11775	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
K5706_RS11780	COG0583	DNA-binding transcription factor activity
K5706_RS11785	COG0450	alkyl hydroperoxide reductase
K5706_RS11810	COG0704	Plays a role in the regulation of phosphate uptake
K5706_RS11815	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K5706_RS11820	COG0581	inorganic phosphate transmembrane transporter activity
K5706_RS11825	COG0573	inorganic phosphate transmembrane transporter activity
K5706_RS11830	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K5706_RS11835	COG0248	Ppx GppA phosphatase
K5706_RS11845	COG5002	protein histidine kinase activity
K5706_RS11850	COG0745	RESPONSE REGULATOR receiver
K5706_RS11855	COG2974	May be involved in recombination
K5706_RS11860	COG0826	peptidase U32
K5706_RS11865	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K5706_RS11920	COG0542	response to heat
K5706_RS11925	COG1496	oxidoreductase activity
K5706_RS11930	COG0564	pseudouridine synthase activity
K5706_RS11935	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K5706_RS11940	COG0741	lytic transglycosylase activity
K5706_RS11945	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K5706_RS11950	COG0077	Prephenate dehydratase
K5706_RS11950	COG1605	Chorismate mutase
K5706_RS11955	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
K5706_RS11970	COG0488	(ABC) transporter
K5706_RS11980	COG0739	heme binding
K5706_RS11985	COG0287	Prephenate dehydrogenase
K5706_RS11985	COG1605	Chorismate mutase
K5706_RS11990	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K5706_RS12000	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
K5706_RS12020	COG1966	Carbon starvation protein
K5706_RS12030	COG3279	Response regulator of the LytR AlgR family
K5706_RS12035	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K5706_RS12040	COG1047	Peptidyl-prolyl cis-trans
K5706_RS12055	COG0196	riboflavin kinase activity
K5706_RS12060	COG0728	peptidoglycan biosynthetic process
K5706_RS12065	COG0268	Binds directly to 16S ribosomal RNA
K5706_RS12070	COG0640	Transcriptional regulator
K5706_RS12075	COG0583	DNA-binding transcription factor activity
K5706_RS12080	COG1283	sodium-dependent phosphate transmembrane transporter activity
K5706_RS12095	COG0730	response to heat
K5706_RS12100	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
K5706_RS12110	COG3066	DNA modification
K5706_RS12120	COG0667	Aldo Keto reductase
K5706_RS12150	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K5706_RS12155	COG4974	Belongs to the 'phage' integrase family
K5706_RS12160	COG0716	FMN binding
K5706_RS12175	COG0513	Belongs to the DEAD box helicase family
K5706_RS12180	COG3022	response to hydroperoxide
K5706_RS12210	COG1115	amino acid carrier protein
K5706_RS12225	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K5706_RS12240	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
K5706_RS12245	COG0083	homoserine kinase activity
K5706_RS12260	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K5706_RS12270	COG0745	RESPONSE REGULATOR receiver
K5706_RS12280	COG2198	Histidine kinase
K5706_RS12280	COG0784	Response regulator, receiver
K5706_RS12280	COG5002	protein histidine kinase activity
K5706_RS12285	COG1242	4 iron, 4 sulfur cluster binding
K5706_RS12290	COG0069	glutamate synthase activity
K5706_RS12290	COG0067	glutamate synthase
K5706_RS12290	COG0070	glutamate synthase
K5706_RS12300	COG0067	glutamate synthase
K5706_RS12300	COG0069	glutamate synthase activity
K5706_RS12300	COG0070	glutamate synthase
K5706_RS12305	COG0493	'glutamate synthase
K5706_RS12330	COG2860	membrane
K5706_RS12335	COG0583	DNA-binding transcription factor activity
K5706_RS12340	COG0730	response to heat
K5706_RS12345	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K5706_RS12350	COG0505	Belongs to the CarA family
K5706_RS12360	COG0494	nUDIX hydrolase
K5706_RS12375	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
K5706_RS12380	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K5706_RS12385	COG0849	cell division
K5706_RS12390	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K5706_RS12405	COG0772	Belongs to the SEDS family
K5706_RS12415	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K5706_RS12420	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K5706_RS12425	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K5706_RS12430	COG0768	penicillin binding
K5706_RS12435	COG3116	cell division
K5706_RS12450	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
K5706_RS12465	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
K5706_RS12470	COG2823	Periplasmic or secreted lipoprotein
K5706_RS12475	COG2969	positive regulation of protein catabolic process
K5706_RS12480	COG0625	glutathione transferase activity
K5706_RS12485	COG2857	Cytochrome c1
K5706_RS12490	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K5706_RS12495	COG0723	plastoquinol--plastocyanin reductase activity
K5706_RS12510	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
K5706_RS12515	COG3105	Protein conserved in bacteria
K5706_RS12530	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K5706_RS12540	COG3150	esterase
K5706_RS12550	COG3151	Protein conserved in bacteria
K5706_RS12555	COG0494	nUDIX hydrolase
K5706_RS12560	COG1538	Outer membrane efflux protein
K5706_RS12570	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
K5706_RS12580	COG3025	triphosphatase activity
K5706_RS12585	COG1392	Phosphate transport regulator
K5706_RS12590	COG0306	phosphate transporter
K5706_RS12595	COG4991	sh3 domain protein
K5706_RS12605	COG3409	Peptidoglycan-binding domain 1 protein
K5706_RS12605	COG3267	Type II secretory pathway component ExeA
K5706_RS12625	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
K5706_RS12635	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K5706_RS12640	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K5706_RS12645	COG0828	Belongs to the bacterial ribosomal protein bS21 family
K5706_RS12650	COG1610	YqeY-like protein
K5706_RS12655	COG0358	DNA primase activity
K5706_RS12680	COG1349	DNA-binding transcription factor activity
K5706_RS12685	COG0469	pyruvate kinase activity
K5706_RS12695	COG3706	GGDEF domain
K5706_RS12705	COG0028	Belongs to the TPP enzyme family
K5706_RS12710	COG1022	Amp-dependent synthetase and ligase
K5706_RS12715	COG0583	DNA-binding transcription factor activity
K5706_RS12735	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K5706_RS12740	COG0473	3-isopropylmalate dehydrogenase activity
K5706_RS12760	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
K5706_RS12765	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
K5706_RS12770	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K5706_RS12775	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
K5706_RS12785	COG2967	ApaG domain
K5706_RS12795	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
K5706_RS12800	COG3610	response to peptide
K5706_RS12805	COG2966	Psort location CytoplasmicMembrane, score
K5706_RS12810	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K5706_RS12820	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K5706_RS12825	COG0142	geranyltranstransferase activity
K5706_RS12845	COG2358	TRAP transporter, solute receptor (TAXI family
K5706_RS12860	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
K5706_RS12865	COG1178	ABC-type Fe3 transport system permease component
K5706_RS12870	COG4143	(ABC) transporter
K5706_RS12875	COG0163	prenyltransferase activity
K5706_RS12880	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K5706_RS12885	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
K5706_RS12890	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
K5706_RS12895	COG2105	PFAM AIG2 family protein
K5706_RS12905	COG0729	surface antigen
K5706_RS12910	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K5706_RS12920	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
K5706_RS12935	COG1136	(ABC) transporter
K5706_RS12955	COG0529	Catalyzes the synthesis of activated sulfate
K5706_RS12960	COG0471	metal ion transport
K5706_RS12960	COG3273	potassium ion transport
K5706_RS12975	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K5706_RS12975	COG1648	precorrin-2 dehydrogenase activity
K5706_RS12980	COG0737	Belongs to the 5'-nucleotidase family
K5706_RS12990	COG0513	Belongs to the DEAD box helicase family
K5706_RS12995	COG2153	protein acetylation
K5706_RS13005	COG0545	Peptidyl-prolyl cis-trans isomerase
K5706_RS13015	COG0203	ribosomal protein L17
K5706_RS13020	COG0202	RNA polymerase activity
K5706_RS13030	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K5706_RS13035	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K5706_RS13045	COG0201	protein transport
K5706_RS13055	COG1841	ribosomal large subunit assembly
K5706_RS13070	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K5706_RS13080	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K5706_RS13085	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K5706_RS13090	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K5706_RS13095	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
K5706_RS13100	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K5706_RS13125	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K5706_RS13130	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K5706_RS13140	COG0088	Forms part of the polypeptide exit tunnel
K5706_RS13145	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K5706_RS13155	COG0254	rRNA binding
K5706_RS13160	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K5706_RS13165	COG1609	Transcriptional regulator
K5706_RS13185	COG1575	Belongs to the MenA family. Type 1 subfamily
K5706_RS13190	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K5706_RS13195	COG3074	FtsZ-dependent cytokinesis
K5706_RS13200	COG1494	fructose-1,6-bisphosphatase
K5706_RS13225	COG0149	triose-phosphate isomerase activity
K5706_RS13240	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
K5706_RS13245	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K5706_RS13325	COG3335	DDE superfamily endonuclease
K5706_RS13340	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
K5706_RS13345	COG0673	inositol 2-dehydrogenase activity
K5706_RS13385	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K5706_RS13405	COG1560	Kdo2-lipid A biosynthetic process
K5706_RS13410	COG0859	PFAM glycosyl transferase family 9
K5706_RS13415	COG1519	Transferase
K5706_RS13425	COG0438	transferase activity, transferring glycosyl groups
K5706_RS13430	COG1028	Short-chain dehydrogenase reductase Sdr
K5706_RS13435	COG1083	cytidylyl-transferase
K5706_RS13440	COG0673	inositol 2-dehydrogenase activity
K5706_RS13445	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K5706_RS13455	COG2089	acid synthase
K5706_RS13460	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
K5706_RS13465	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K5706_RS13470	COG1086	Polysaccharide biosynthesis protein
K5706_RS13475	COG3642	lipopolysaccharide core region biosynthetic process
K5706_RS13480	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K5706_RS13485	COG0859	PFAM glycosyl transferase family 9
K5706_RS13490	COG0463	Glycosyl transferase, family 2
K5706_RS13495	COG0438	transferase activity, transferring glycosyl groups
K5706_RS13530	COG0227	Belongs to the bacterial ribosomal protein bL28 family
K5706_RS13540	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K5706_RS13545	COG1309	transcriptional regulator
K5706_RS13550	COG1560	Kdo2-lipid A biosynthetic process
K5706_RS13555	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K5706_RS13560	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
K5706_RS13565	COG1561	YicC-like family, N-terminal region
K5706_RS13590	COG4608	Belongs to the ABC transporter superfamily
K5706_RS13595	COG0444	Belongs to the ABC transporter superfamily
K5706_RS13600	COG0747	negative chemotaxis
K5706_RS13605	COG4239	(ABC) transporter, permease
K5706_RS13610	COG4174	ABC transporter (Permease)
K5706_RS13630	COG0811	peptide transport
K5706_RS13635	COG0848	biopolymer transport protein
K5706_RS13655	COG0194	GDP metabolic process
K5706_RS13660	COG1758	RNA polymerase activity
K5706_RS13665	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K5706_RS13670	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K5706_RS13675	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K5706_RS13680	COG0823	Involved in the tonB-independent uptake of proteins
K5706_RS13680	COG1506	peptidase
K5706_RS13680	COG4946	Tricorn protease homolog
K5706_RS13685	COG2233	PERMEase
K5706_RS13705	COG2801	Transposase and inactivated derivatives
K5706_RS13715	COG2183	response to ionizing radiation
K5706_RS13740	COG0494	nUDIX hydrolase
K5706_RS13745	COG1218	3'(2'),5'-bisphosphate nucleotidase
K5706_RS13755	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
K5706_RS13760	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
K5706_RS13765	COG3156	type II secretion system protein K
K5706_RS13770	COG4795	General secretion pathway protein
K5706_RS13775	COG2165	general secretion pathway protein
K5706_RS13780	COG2165	general secretion pathway protein
K5706_RS13785	COG2165	general secretion pathway protein
K5706_RS13790	COG1459	type II secretion system
K5706_RS13795	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K5706_RS13805	COG3031	protein transport across the cell outer membrane
K5706_RS13810	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
K5706_RS13830	COG0456	acetyltransferase
K5706_RS13835	COG1490	D-aminoacyl-tRNA deacylase activity
K5706_RS13855	COG1217	gtp-binding protein TYPA
K5706_RS13860	COG0174	glutamine synthetase
K5706_RS13870	COG3852	Histidine kinase
K5706_RS13875	COG2204	response regulator
K5706_RS13885	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K5706_RS13915	COG0218	Necessary for normal cell division and for the maintenance of normal septation
K5706_RS13920	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K5706_RS13920	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K5706_RS13935	COG0084	hydrolase, TatD family'
K5706_RS13940	COG0805	protein transport
K5706_RS13945	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K5706_RS13960	COG3165	ubiquinone biosynthetic process from chorismate
K5706_RS13970	COG1322	Protein conserved in bacteria
K5706_RS13980	COG3300	MHYT domain
K5706_RS13980	COG5001	Diguanylate cyclase
K5706_RS13985	COG2081	HI0933 family
K5706_RS13995	COG1528	Iron-storage protein
K5706_RS14000	COG0589	response to stress
K5706_RS14020	COG1522	sequence-specific DNA binding
K5706_RS14030	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
K5706_RS14035	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K5706_RS14040	COG0800	Aldolase
K5706_RS14045	COG2610	gluconate transmembrane transporter activity
K5706_RS14050	COG3265	gluconokinase activity
K5706_RS14055	COG0129	dihydroxy-acid dehydratase activity
K5706_RS14065	COG2076	Multidrug Resistance protein
K5706_RS14070	COG0583	DNA-binding transcription factor activity
K5706_RS14075	COG1609	Transcriptional regulator
K5706_RS14115	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K5706_RS14120	COG0601	transmembrane transport
K5706_RS14125	COG0747	negative chemotaxis
K5706_RS14130	COG4172	Belongs to the ABC transporter superfamily
K5706_RS14175	COG1309	transcriptional regulator
K5706_RS14180	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K5706_RS14185	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K5706_RS14190	COG2960	long-chain fatty acid transporting porin activity
K5706_RS14195	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K5706_RS14200	COG0583	DNA-binding transcription factor activity
K5706_RS14245	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
K5706_RS14270	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
K5706_RS14275	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K5706_RS14290	COG0551	DNA topoisomerase type I activity
K5706_RS14300	COG0758	DNA mediated transformation
K5706_RS14310	COG0242	peptide deformylase activity
K5706_RS14320	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K5706_RS14320	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K5706_RS14325	COG0569	domain protein
K5706_RS14330	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K5706_RS14340	COG1272	protein, Hemolysin III
K5706_RS14345	COG4326	sporulation control protein
K5706_RS14355	COG3084	Protein conserved in bacteria
K5706_RS14365	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
K5706_RS14370	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K5706_RS14375	COG0204	Acyl-transferase
K5706_RS14385	COG0606	chelatase, subunit chli
K5706_RS14395	COG3978	acetolactate synthase activity
K5706_RS14400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K5706_RS14405	COG0129	dihydroxy-acid dehydratase activity
K5706_RS14415	COG0583	DNA-binding transcription factor activity
K5706_RS14420	COG2814	Major facilitator Superfamily
K5706_RS14430	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K5706_RS14435	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K5706_RS14440	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K5706_RS14445	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K5706_RS14455	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K5706_RS14470	COG3312	ion transport
K5706_RS14475	COG1475	DNA binding
K5706_RS14480	COG1192	Involved in chromosome partitioning
K5706_RS14490	COG0445	tRNA wobble uridine modification
K5706_RS14495	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K5706_RS14505	COG0706	membrane insertase activity
K5706_RS14515	COG0594	ribonuclease P activity
K5706_RS14525	COG1126	abc transporter atp-binding protein
K5706_RS14545	COG2115	Belongs to the xylose isomerase family
K5706_RS14550	COG1609	Transcriptional regulator
K5706_RS14550	COG2207	Transcriptional regulator
K5706_RS14555	COG1070	Carbohydrate kinase
K5706_RS14565	COG1609	Transcriptional regulator
K5706_RS14580	COG0395	ABC-type sugar transport system, permease component
K5706_RS14585	COG2723	6-phospho-beta-galactosidase activity
K5706_RS14590	COG3842	ATPase activity
K5706_RS14595	COG1609	Transcriptional regulator
K5706_RS14605	COG0747	negative chemotaxis
K5706_RS14615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K5706_RS14620	COG0444	Belongs to the ABC transporter superfamily
K5706_RS14625	COG4608	Belongs to the ABC transporter superfamily
K5706_RS14635	COG1609	Transcriptional regulator
K5706_RS14655	COG1472	Belongs to the glycosyl hydrolase 3 family
K5706_RS14660	COG0534	Mate efflux family protein
K5706_RS14665	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
K5706_RS14670	COG0564	pseudouridine synthase activity
K5706_RS14675	COG0561	phosphatase activity
K5706_RS14685	COG2199	diguanylate cyclase activity
K5706_RS14695	COG3152	Membrane
K5706_RS14705	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
K5706_RS14715	COG0583	DNA-binding transcription factor activity
K5706_RS14745	COG2076	Multidrug Resistance protein
K5706_RS14755	COG3047	cAMP biosynthetic process
K5706_RS14760	COG2358	TRAP transporter, solute receptor (TAXI family
K5706_RS14775	COG2814	Major facilitator Superfamily
K5706_RS14875	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
K5706_RS14880	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K5706_RS14885	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K5706_RS14890	COG1116	anion transmembrane transporter activity
K5706_RS14895	COG0351	phosphomethylpyrimidine kinase
K5706_RS14900	COG0312	modulator of DNA gyrase
K5706_RS14905	COG0312	modulator of DNA gyrase
K5706_RS14975	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K5706_RS14985	COG0584	glycerophosphoryl diester phosphodiesterase
K5706_RS15010	COG0811	peptide transport
K5706_RS15015	COG0811	peptide transport
K5706_RS15020	COG0848	biopolymer transport protein
K5706_RS15040	COG1770	oligopeptidase
K5706_RS15045	COG2814	Major facilitator Superfamily
K5706_RS15050	COG0010	Belongs to the arginase family
K5706_RS15055	COG1166	arginine decarboxylase activity
K5706_RS15065	COG0189	ligase activity
K5706_RS15065	COG4067	protein conserved in archaea
K5706_RS15070	COG0189	ligase activity
K5706_RS15075	COG0583	DNA-binding transcription factor activity
K5706_RS15100	COG2204	response regulator
K5706_RS15105	COG3706	GGDEF domain
K5706_RS15110	COG1114	Component of the transport system for branched-chain amino acids
K5706_RS15125	COG0579	oxidoreductase
K5706_RS15140	COG3033	Beta-eliminating lyase
K5706_RS15155	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K5706_RS15180	COG3706	GGDEF domain
K5706_RS15185	COG0415	Belongs to the DNA photolyase family
K5706_RS15190	COG3046	protein related to deoxyribodipyrimidine photolyase
K5706_RS15205	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K5706_RS15205	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K5706_RS15210	COG1765	OsmC-like protein
K5706_RS15225	COG1011	Hydrolase
K5706_RS15245	COG1511	domain protein
K5706_RS15245	COG3264	Mechanosensitive ion channel
K5706_RS15250	COG2866	Carboxypeptidase
K5706_RS15270	COG3104	oligopeptide transport
K5706_RS15275	COG1760	l-serine dehydratase
K5706_RS15300	COG1388	LysM domain
K5706_RS15300	COG0741	lytic transglycosylase activity
K5706_RS15320	COG1815	bacterial-type flagellum-dependent cell motility
K5706_RS15325	COG1558	bacterial-type flagellum-dependent cell motility
K5706_RS15330	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
K5706_RS15345	COG4786	Flagellar basal body rod
K5706_RS15350	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
K5706_RS15355	COG1706	bacterial-type flagellum-dependent cell motility
K5706_RS15365	COG1256	bacterial-type flagellum assembly
K5706_RS15365	COG4786	Flagellar basal body rod
K5706_RS15395	COG0583	DNA-binding transcription factor activity
K5706_RS15420	COG1360	Flagellar Motor Protein
K5706_RS15425	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K5706_RS15430	COG1191	sigma factor activity
K5706_RS15435	COG1580	Controls the rotational direction of flagella during chemotaxis
K5706_RS15450	COG1516	flagellar protein fliS
K5706_RS15455	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
K5706_RS15470	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K5706_RS15495	COG1987	bacterial-type flagellum assembly
K5706_RS15525	COG1677	Flagellar hook-basal body complex protein FliE
K5706_RS15570	COG0346	lactoylglutathione lyase activity
K5706_RS15595	COG0745	RESPONSE REGULATOR receiver
K5706_RS15605	COG3293	Transposase
K5706_RS15625	COG0156	8-amino-7-oxononanoate synthase activity
K5706_RS15630	COG1063	alcohol dehydrogenase
K5706_RS15635	COG0582	viral genome integration into host DNA
K5706_RS15750	COG1403	HNH endonuclease
K5706_RS15790	COG4220	transposase activity
K5706_RS15925	COG1304	FMN binding
K5706_RS15930	COG0583	DNA-binding transcription factor activity
K5706_RS15935	COG1505	serine-type exopeptidase activity
K5706_RS15940	COG1067	ATP-dependent peptidase activity
K5706_RS15955	COG1247	-acetyltransferase
K5706_RS15960	COG0437	4 iron, 4 sulfur cluster binding
K5706_RS15965	COG0348	domain, Protein
K5706_RS15970	COG0640	Transcriptional regulator
K5706_RS15985	COG1122	ATPase activity
K5706_RS15995	COG1566	PFAM secretion protein HlyD family protein
K5706_RS16025	COG0813	purine-nucleoside phosphorylase activity
K5706_RS16030	COG3272	Protein of unknown function (DUF1722)
K5706_RS16040	COG0415	Belongs to the DNA photolyase family
K5706_RS16045	COG1376	ErfK ybiS ycfS ynhG family protein
K5706_RS16045	COG1388	LysM domain
K5706_RS16055	COG0513	Belongs to the DEAD box helicase family
K5706_RS16065	COG0573	inorganic phosphate transmembrane transporter activity
K5706_RS16070	COG0581	inorganic phosphate transmembrane transporter activity
K5706_RS16075	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K5706_RS16080	COG3706	GGDEF domain
K5706_RS16090	COG2304	oxidoreductase activity
K5706_RS16110	COG0714	Associated with various cellular activities
K5706_RS16115	COG0840	transmembrane signaling receptor activity
K5706_RS16125	COG2197	response regulator
K5706_RS16130	COG0110	maltose O-acetyltransferase activity
K5706_RS16135	COG1028	Short-chain dehydrogenase reductase Sdr
K5706_RS16140	COG2203	Gaf domain
K5706_RS16140	COG3706	GGDEF domain
K5706_RS16140	COG4251	negative regulation of phosphorylation
K5706_RS16140	COG5001	Diguanylate cyclase
K5706_RS16165	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K5706_RS16170	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K5706_RS16175	COG2801	Transposase and inactivated derivatives
K5706_RS16180	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
K5706_RS16190	COG1252	NADH dehydrogenase
K5706_RS16195	COG1301	dicarboxylic acid transport
K5706_RS16200	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K5706_RS16205	COG2706	6-phosphogluconolactonase activity
K5706_RS16210	COG1881	PFAM PEBP family protein
K5706_RS16220	COG0798	PFAM Bile acid sodium symporter
K5706_RS16245	COG0814	amino acid
K5706_RS16255	COG3314	Sporulation integral membrane protein YlbJ
K5706_RS16275	COG0739	heme binding
K5706_RS16285	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K5706_RS16290	COG0697	spore germination
K5706_RS16305	COG0179	Fumarylacetoacetate (FAA) hydrolase
K5706_RS16320	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
K5706_RS16325	COG1280	lysine exporter protein (LysE YggA)
K5706_RS16330	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K5706_RS16345	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
K5706_RS16350	COG1845	cytochrome c oxidase, subunit III
K5706_RS16370	COG1612	heme a metabolic process
K5706_RS16385	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K5706_RS16410	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K5706_RS16430	COG2897	thiosulfate sulfurtransferase activity
K5706_RS16465	COG1914	H( )-stimulated, divalent metal cation uptake system
K5706_RS16490	COG4989	oxidoreductase activity
K5706_RS16505	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
K5706_RS16505	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
K5706_RS16515	COG1247	-acetyltransferase
K5706_RS16530	COG1566	PFAM secretion protein HlyD family protein
K5706_RS16540	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K5706_RS16545	COG0076	glutamate decarboxylase activity
K5706_RS16580	COG4176	ABC-type proline glycine betaine transport system permease component
K5706_RS16585	COG0517	IMP dehydrogenase activity
K5706_RS16585	COG4175	Glycine betaine
K5706_RS16610	COG3300	MHYT domain
K5706_RS16610	COG5001	Diguanylate cyclase
K5706_RS16655	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
K5706_RS16665	COG0438	transferase activity, transferring glycosyl groups
K5706_RS16705	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
K5706_RS16710	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
K5706_RS16715	COG3206	protein involved in exopolysaccharide biosynthesis
K5706_RS16715	COG0489	protein tyrosine kinase activity
K5706_RS16730	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K5706_RS16760	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K5706_RS16770	COG1869	D-ribose catabolic process
K5706_RS16775	COG0738	Major facilitator superfamily
K5706_RS16790	COG1609	Transcriptional regulator
K5706_RS16800	COG0789	Transcriptional regulator
K5706_RS16820	COG1289	transmembrane transporter activity
K5706_RS16825	COG0210	DNA helicase
K5706_RS16835	COG1879	ABC-type sugar transport system periplasmic component
K5706_RS16840	COG2198	Histidine kinase
K5706_RS16840	COG2205	protein histidine kinase activity
K5706_RS16840	COG0784	Response regulator, receiver
K5706_RS16855	COG3119	arylsulfatase activity
K5706_RS16860	COG3119	arylsulfatase activity
K5706_RS16865	COG3063	Type IV pilus biogenesis stability protein PilW
K5706_RS16870	COG0714	Associated with various cellular activities
K5706_RS16905	COG0583	DNA-binding transcription factor activity
K5706_RS16910	COG3111	PFAM Bacterial OB fold (BOF) protein
K5706_RS16930	COG0641	radical SAM
K5706_RS16955	COG3069	C4-dicarboxylate transmembrane transporter activity
K5706_RS16975	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
K5706_RS16980	COG0778	Nitroreductase
K5706_RS16985	COG0784	Response regulator, receiver
K5706_RS16985	COG0835	chemotaxis
K5706_RS16990	COG2165	general secretion pathway protein
K5706_RS17000	COG2962	Rard protein
K5706_RS17015	COG0671	phosphoesterase, PA-phosphatase related
K5706_RS17045	COG2067	long-chain fatty acid transport protein
K5706_RS17060	COG1902	pentaerythritol trinitrate reductase activity
K5706_RS17065	COG0346	lactoylglutathione lyase activity
K5706_RS17070	COG0420	3'-5' exonuclease activity
K5706_RS17075	COG0419	ATPase involved in DNA repair
K5706_RS17085	COG3469	chitinase activity
K5706_RS17105	COG3040	lipid binding
K5706_RS17175	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K5706_RS17185	COG0509	glycine decarboxylation via glycine cleavage system
K5706_RS17190	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K5706_RS17200	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K5706_RS17230	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K5706_RS17230	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
K5706_RS17230	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K5706_RS17235	COG1105	Belongs to the carbohydrate kinase PfkB family
K5706_RS17240	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K5706_RS17240	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K5706_RS17245	COG1609	Transcriptional regulator
K5706_RS17265	COG0668	transmembrane transport
K5706_RS17285	COG2239	Acts as a magnesium transporter
K5706_RS17295	COG0387	Pfam Sodium calcium exchanger
K5706_RS17305	COG0765	amino acid transport
K5706_RS17310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K5706_RS17315	COG0765	amino acid transport
K5706_RS17320	COG1126	abc transporter atp-binding protein
K5706_RS17325	COG1979	alcohol dehydrogenase
K5706_RS17330	COG2207	Transcriptional regulator
K5706_RS17345	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K5706_RS17360	COG0784	Response regulator, receiver
K5706_RS17360	COG3437	response regulator, receiver
K5706_RS17365	COG0546	phosphoglycolate phosphatase activity
K5706_RS17370	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
K5706_RS17375	COG0513	Belongs to the DEAD box helicase family
K5706_RS17390	COG3038	cytochrome b561
K5706_RS17400	COG2116	formate transmembrane transporter activity
K5706_RS17405	COG0583	DNA-binding transcription factor activity
K5706_RS17415	COG3593	DNA synthesis involved in DNA repair
K5706_RS17420	COG0737	Belongs to the 5'-nucleotidase family
K5706_RS17425	COG0861	Integral membrane protein TerC family
K5706_RS17445	COG2267	carboxylic ester hydrolase activity
K5706_RS17450	COG2067	long-chain fatty acid transport protein
K5706_RS17465	COG2050	protein possibly involved in aromatic compounds catabolism
K5706_RS17475	COG4533	DNA binding
K5706_RS17500	COG0484	heat shock protein binding
K5706_RS17510	COG3300	MHYT domain
K5706_RS17510	COG5001	Diguanylate cyclase
K5706_RS17515	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K5706_RS17525	COG4181	ATPase activity
K5706_RS17530	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
K5706_RS17540	COG1984	allophanate hydrolase subunit 2
K5706_RS17545	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
K5706_RS17555	COG3447	MASE1 domain protein
K5706_RS17555	COG5001	Diguanylate cyclase
K5706_RS17555	COG5002	protein histidine kinase activity
K5706_RS17570	COG0583	DNA-binding transcription factor activity
K5706_RS17575	COG0045	succinate-CoA ligase (ADP-forming) activity
K5706_RS17575	COG1042	CoA-binding domain protein
K5706_RS17575	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K5706_RS17595	COG0023	Translation Initiation Factor
K5706_RS17610	COG3140	Belongs to the UPF0181 family
K5706_RS17635	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
K5706_RS17640	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
K5706_RS17665	COG4251	negative regulation of phosphorylation
K5706_RS17665	COG5001	Diguanylate cyclase
K5706_RS17665	COG2203	Gaf domain
K5706_RS17665	COG3706	GGDEF domain
K5706_RS17675	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
K5706_RS17680	COG4149	molybdate abc transporter
K5706_RS17695	COG3111	PFAM Bacterial OB fold (BOF) protein
K5706_RS17705	COG4067	protein conserved in archaea
K5706_RS17705	COG0189	ligase activity
K5706_RS17720	COG0534	Mate efflux family protein
K5706_RS17725	COG0602	queuosine metabolic process
K5706_RS17730	COG1328	CTP reductase activity
K5706_RS17765	COG1396	sequence-specific DNA binding
K5706_RS17770	COG3550	peptidyl-serine autophosphorylation
K5706_RS17795	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
K5706_RS17800	COG0732	type I restriction modification DNA specificity domain
K5706_RS17805	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K5706_RS17850	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
K5706_RS17890	COG1484	DNA-dependent DNA replication
K5706_RS17895	COG4584	PFAM Integrase catalytic
K5706_RS17950	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K5706_RS17955	COG0446	pyridine nucleotide-disulphide oxidoreductase
K5706_RS17970	COG0402	S-adenosylhomocysteine deaminase activity
K5706_RS17985	COG0628	permease
K5706_RS17995	COG1566	PFAM secretion protein HlyD family protein
K5706_RS18010	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K5706_RS18015	COG3118	belongs to the thioredoxin family
K5706_RS18055	COG2116	formate transmembrane transporter activity
K5706_RS18065	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K5706_RS18070	COG3706	GGDEF domain
K5706_RS18115	COG0277	FAD linked oxidase domain protein
K5706_RS18125	COG2425	protein containing a von Willebrand factor type A (vWA) domain
K5706_RS18140	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
K5706_RS18150	COG1288	antiporter activity
K5706_RS18160	COG2814	Major facilitator Superfamily
K5706_RS18170	COG1196	nuclear chromosome segregation
K5706_RS18190	COG1132	(ABC) transporter
K5706_RS18220	COG0318	PFAM AMP-dependent synthetase and ligase
K5706_RS18230	COG0628	permease
K5706_RS18270	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K5706_RS18270	COG2146	nitrite reductase [NAD(P)H] activity
K5706_RS18275	COG1116	anion transmembrane transporter activity
K5706_RS18280	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K5706_RS18285	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K5706_RS18285	COG1116	anion transmembrane transporter activity
K5706_RS18290	COG3707	response regulator
K5706_RS18305	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K5706_RS18305	COG1648	precorrin-2 dehydrogenase activity
K5706_RS18310	COG0243	molybdopterin cofactor binding
K5706_RS18320	COG0814	amino acid
K5706_RS18340	COG1785	Belongs to the alkaline phosphatase family
K5706_RS18345	COG5002	protein histidine kinase activity
K5706_RS18350	COG0745	RESPONSE REGULATOR receiver
K5706_RS18365	COG2801	Transposase and inactivated derivatives
K5706_RS18375	COG0443	Heat shock 70 kDa protein
K5706_RS18390	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K5706_RS18430	COG4160	amino acid transport
K5706_RS18435	COG4215	(ABC) transporter
K5706_RS18440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K5706_RS18445	COG1126	abc transporter atp-binding protein
K5706_RS18460	COG0446	pyridine nucleotide-disulphide oxidoreductase
K5706_RS18460	COG1902	pentaerythritol trinitrate reductase activity
K5706_RS18465	COG1028	Short-chain dehydrogenase reductase Sdr
K5706_RS18475	COG1024	Enoyl-CoA hydratase
K5706_RS18480	COG1024	Enoyl-CoA hydratase
K5706_RS18485	COG1960	acyl-CoA dehydrogenase activity
K5706_RS18505	COG1960	acyl-CoA dehydrogenase activity
K5706_RS18510	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K5706_RS18515	COG1024	Enoyl-CoA hydratase
K5706_RS18535	COG3278	Belongs to the heme-copper respiratory oxidase family
K5706_RS18550	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K5706_RS18555	COG0513	Belongs to the DEAD box helicase family
K5706_RS18560	COG3335	DDE superfamily endonuclease
K5706_RS18575	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
K5706_RS18590	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K5706_RS18690	COG1396	sequence-specific DNA binding
K5706_RS18690	COG1917	Cupin 2, conserved barrel domain protein
K5706_RS18700	COG1566	PFAM secretion protein HlyD family protein
K5706_RS18725	COG2801	Transposase and inactivated derivatives
K5706_RS18730	COG3293	Transposase
K5706_RS18740	COG3706	GGDEF domain
K5706_RS18745	COG2252	PERMEase
K5706_RS18750	COG1119	ATPase activity
K5706_RS18770	COG0513	Belongs to the DEAD box helicase family
K5706_RS18775	COG0523	cobalamin synthesis protein
K5706_RS18805	COG3416	Protein conserved in bacteria
K5706_RS18815	COG3293	Transposase
K5706_RS18825	COG3530	Putative quorum-sensing-regulated virulence factor
K5706_RS18855	COG3186	Phenylalanine-4-hydroxylase
K5706_RS18860	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K5706_RS18865	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K5706_RS18890	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
K5706_RS18895	COG1454	alcohol dehydrogenase
K5706_RS18900	COG2133	pyrroloquinoline quinone binding
K5706_RS18910	COG0783	Belongs to the Dps family
K5706_RS18915	COG0840	transmembrane signaling receptor activity
K5706_RS18925	COG1136	(ABC) transporter
K5706_RS18925	COG0577	efflux transmembrane transporter activity
K5706_RS18930	COG0577	efflux transmembrane transporter activity
K5706_RS18930	COG1136	(ABC) transporter
K5706_RS18945	COG1278	Cold shock
K5706_RS18975	COG0545	Peptidyl-prolyl cis-trans isomerase
K5706_RS19000	COG2197	response regulator
K5706_RS19005	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K5706_RS19015	COG0840	transmembrane signaling receptor activity
K5706_RS19035	COG2195	Cleaves the N-terminal amino acid of tripeptides
K5706_RS19050	COG2197	response regulator
K5706_RS19055	COG3850	Histidine kinase
K5706_RS19060	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K5706_RS19080	COG3005	denitrification pathway
K5706_RS19100	COG0183	Belongs to the thiolase family
K5706_RS19110	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K5706_RS19115	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K5706_RS19130	COG1522	sequence-specific DNA binding
K5706_RS19150	COG2827	Endonuclease containing a URI domain
K5706_RS19175	COG0673	inositol 2-dehydrogenase activity
K5706_RS19195	COG0583	DNA-binding transcription factor activity
K5706_RS19220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K5706_RS19240	COG1566	PFAM secretion protein HlyD family protein
K5706_RS19245	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K5706_RS19250	COG2239	Acts as a magnesium transporter
K5706_RS19255	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
K5706_RS19260	COG0402	S-adenosylhomocysteine deaminase activity
K5706_RS19275	COG1418	mRNA catabolic process
K5706_RS19285	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K5706_RS19300	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K5706_RS19315	COG4221	oxidoreductase activity
K5706_RS19320	COG0745	RESPONSE REGULATOR receiver
K5706_RS19325	COG2205	protein histidine kinase activity
K5706_RS19335	COG2194	sulfuric ester hydrolase activity
K5706_RS19350	COG2814	Major facilitator Superfamily
K5706_RS19370	COG0583	DNA-binding transcription factor activity
K5706_RS19375	COG2249	NAD(P)H dehydrogenase (quinone) activity
K5706_RS19390	COG0583	DNA-binding transcription factor activity
K5706_RS19415	COG0366	Alpha amylase catalytic
K5706_RS19495	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K5706_RS19500	COG0835	chemotaxis
K5706_RS19500	COG0784	Response regulator, receiver
K5706_RS19510	COG0748	coenzyme F420 binding
K5706_RS19515	COG3721	Heme iron utilization protein
K5706_RS19525	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
K5706_RS19530	COG0811	peptide transport
K5706_RS19535	COG0848	biopolymer transport protein
K5706_RS19545	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K5706_RS19550	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
K5706_RS19595	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K5706_RS19605	COG0633	Ferredoxin
K5706_RS19605	COG3217	Mosc domain protein beta barrel domain protein
K5706_RS19605	COG3217	Mosc domain protein beta barrel domain protein
K5706_RS19605	COG0633	Ferredoxin
K5706_RS19610	COG0401	homolog of Blt101
K5706_RS19620	COG2354	Protein conserved in bacteria
K5706_RS19630	COG2999	glutathione oxidoreductase activity
K5706_RS19635	COG0604	alcohol dehydrogenase
K5706_RS19695	COG3833	ABC-type maltose transport systems, permease component
K5706_RS19700	COG1175	transmembrane transport
K5706_RS19715	COG3842	ATPase activity
K5706_RS19725	COG1309	transcriptional regulator
K5706_RS19730	COG2130	NADP-dependent
K5706_RS19740	COG0753	catalase activity
K5706_RS19745	COG2084	Dehydrogenase
K5706_RS19755	COG0583	DNA-binding transcription factor activity
K5706_RS19760	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K5706_RS19765	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K5706_RS19775	COG2207	Transcriptional regulator
K5706_RS19780	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K5706_RS19780	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K5706_RS19780	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K5706_RS19785	COG1482	cell wall glycoprotein biosynthetic process
K5706_RS19790	COG2211	Major facilitator Superfamily
K5706_RS19795	COG1486	melibiose metabolic process
K5706_RS19800	COG2169	Transcriptional regulator
K5706_RS19820	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K5706_RS19825	COG2249	NAD(P)H dehydrogenase (quinone) activity
K5706_RS19830	COG2233	PERMEase
K5706_RS19835	COG0402	S-adenosylhomocysteine deaminase activity
K5706_RS19850	COG3383	formate dehydrogenase (NAD+) activity
K5706_RS19870	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K5706_RS19895	COG0604	alcohol dehydrogenase
K5706_RS19895	COG3321	synthase
K5706_RS19895	COG1028	Short-chain dehydrogenase reductase Sdr
K5706_RS19910	COG0494	nUDIX hydrolase
K5706_RS19915	COG1247	-acetyltransferase
K5706_RS19920	COG1505	serine-type exopeptidase activity
K5706_RS19930	COG0589	response to stress
K5706_RS19960	COG1741	Belongs to the pirin family
K5706_RS19965	COG1278	Cold shock
K5706_RS19975	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K5706_RS19975	COG0678	peroxiredoxin activity
K5706_RS19985	COG1686	Belongs to the peptidase S11 family
K5706_RS19990	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K5706_RS19995	COG2249	NAD(P)H dehydrogenase (quinone) activity
K5706_RS20000	COG0583	DNA-binding transcription factor activity
K5706_RS20005	COG0625	glutathione transferase activity
K5706_RS20015	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
K5706_RS20020	COG1028	Short-chain dehydrogenase reductase Sdr
K5706_RS20035	COG1028	Short-chain dehydrogenase reductase Sdr
K5706_RS20045	COG0583	DNA-binding transcription factor activity
K5706_RS20050	COG2207	Transcriptional regulator
K5706_RS20050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K5706_RS20055	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K5706_RS20080	COG0513	Belongs to the DEAD box helicase family
K5706_RS20085	COG4977	sequence-specific DNA binding
K5706_RS20100	COG0589	response to stress
K5706_RS20105	COG3122	Protein conserved in bacteria
K5706_RS20120	COG0583	DNA-binding transcription factor activity
K5706_RS20125	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K5706_RS20145	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
K5706_RS20150	COG0574	Belongs to the PEP-utilizing enzyme family
K5706_RS20150	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K5706_RS20160	COG3302	dmso reductase anchor subunit
K5706_RS20165	COG0437	4 iron, 4 sulfur cluster binding
K5706_RS20170	COG0243	molybdopterin cofactor binding
K5706_RS20175	COG3381	protein complex oligomerization
K5706_RS20190	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K5706_RS20205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K5706_RS20220	COG0786	glutamate:sodium symporter activity
K5706_RS20235	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K5706_RS20255	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K5706_RS20305	COG3710	Transcriptional regulator
K5706_RS20315	COG3710	Transcriptional regulator
K5706_RS20330	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K5706_RS20350	COG1342	Belongs to the UPF0251 family
K5706_RS20360	COG4176	ABC-type proline glycine betaine transport system permease component
K5706_RS20365	COG3448	diguanylate cyclase activity
K5706_RS20365	COG4175	Glycine betaine
K5706_RS20370	COG3015	lipoprotein NlpE involved in copper resistance
K5706_RS20375	COG0583	DNA-binding transcription factor activity
K5706_RS20415	COG1335	isochorismatase
K5706_RS20440	COG0346	lactoylglutathione lyase activity
K5706_RS20455	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K5706_RS20465	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K5706_RS20495	COG4628	conserved protein (DUF2132)
K5706_RS20500	COG0488	(ABC) transporter
K5706_RS20535	COG0628	permease
K5706_RS20540	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
K5706_RS20550	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K5706_RS20560	COG4628	conserved protein (DUF2132)
K5706_RS20565	COG0583	DNA-binding transcription factor activity
K5706_RS20585	COG1234	tRNA 3'-trailer cleavage
K5706_RS20600	COG1686	Belongs to the peptidase S11 family
K5706_RS20615	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
K5706_RS20625	COG3397	chitin binding
K5706_RS20640	COG0840	transmembrane signaling receptor activity
K5706_RS20645	COG4667	esterase of the alpha-beta hydrolase superfamily
K5706_RS20680	COG2095	MarC family integral membrane protein
K5706_RS20685	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K5706_RS20715	COG1301	dicarboxylic acid transport
K5706_RS20720	COG3339	Conserved Protein
K5706_RS20725	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K5706_RS20730	COG0700	Nucleoside recognition
K5706_RS20735	COG3366	ferrous iron transmembrane transporter activity
K5706_RS20740	COG0366	Alpha amylase catalytic
K5706_RS20745	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K5706_RS20750	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
K5706_RS20755	COG1640	4-alpha-glucanotransferase
K5706_RS20760	COG0058	SHG alpha-glucan phosphorylase activity
K5706_RS20790	COG1263	PTS System
K5706_RS20790	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5706_RS20795	COG1162	GTPase activity
K5706_RS20800	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
K5706_RS20815	COG0531	amino acid
K5706_RS20820	COG1982	Orn Lys Arg decarboxylase major
K5706_RS20840	COG0366	Alpha amylase catalytic
K5706_RS20855	COG4580	involved in the transport of maltose and maltodextrins
K5706_RS20865	COG3706	GGDEF domain
K5706_RS20885	COG4771	TonB-dependent receptor
K5706_RS20890	COG0583	DNA-binding transcription factor activity
K5706_RS20895	COG4607	ABC-type enterochelin transport system periplasmic component
K5706_RS20900	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K5706_RS20905	COG4605	iron ion homeostasis
K5706_RS20910	COG4604	ABC transporter, ATP-binding protein
K5706_RS20950	COG1566	PFAM secretion protein HlyD family protein
K5706_RS20970	COG0826	peptidase U32
K5706_RS20985	COG1136	(ABC) transporter
K5706_RS20990	COG0577	efflux transmembrane transporter activity
K5706_RS21015	COG3634	alkyl hydroperoxide reductase activity
K5706_RS21020	COG1278	Cold shock
K5706_RS21025	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K5706_RS21030	COG1522	sequence-specific DNA binding
K5706_RS21035	COG0006	proline dipeptidase activity
K5706_RS21060	COG0596	Alpha beta hydrolase
K5706_RS21070	COG0513	Belongs to the DEAD box helicase family
K5706_RS21075	COG1312	Catalyzes the dehydration of D-mannonate
K5706_RS21080	COG0246	Mannitol dehydrogenase
K5706_RS21085	COG1904	glucuronate isomerase
K5706_RS21090	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K5706_RS21095	COG0800	Aldolase
K5706_RS21115	COG3250	beta-galactosidase activity
K5706_RS21125	COG2186	Transcriptional regulator
K5706_RS21145	COG1132	(ABC) transporter
K5706_RS21185	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K5706_RS21210	COG0259	pyridoxamine-phosphate oxidase activity
K5706_RS21265	COG1444	tRNA N-acetyltransferase activity
K5706_RS21305	COG0772	Belongs to the SEDS family
K5706_RS21315	COG1566	PFAM secretion protein HlyD family protein
K5706_RS21320	COG0583	DNA-binding transcription factor activity
K5706_RS21330	COG1136	(ABC) transporter
K5706_RS21350	COG3275	phosphorelay sensor kinase activity
K5706_RS21355	COG3279	Response regulator of the LytR AlgR family
K5706_RS21365	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K5706_RS21385	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K5706_RS21390	COG1999	signal sequence binding
K5706_RS21430	COG0786	glutamate:sodium symporter activity
K5706_RS21440	COG1131	(ABC) transporter
K5706_RS21445	COG0786	glutamate:sodium symporter activity
K5706_RS21450	COG3119	arylsulfatase activity
K5706_RS21465	COG0641	radical SAM
K5706_RS21470	COG3119	arylsulfatase activity
K5706_RS21485	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K5706_RS21490	COG0800	Aldolase
K5706_RS21520	COG1566	PFAM secretion protein HlyD family protein
K5706_RS21570	COG3119	arylsulfatase activity
K5706_RS21575	COG1349	DNA-binding transcription factor activity
K5706_RS21585	COG2222	sugar isomerase
K5706_RS21590	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5706_RS21595	COG3715	PTS system
K5706_RS21600	COG3716	PTS system mannose fructose sorbose family IID component
K5706_RS21605	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
K5706_RS21620	COG1028	Short-chain dehydrogenase reductase Sdr
K5706_RS21660	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
K5706_RS21665	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K5706_RS21675	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K5706_RS21705	COG3123	guanosine phosphorylase activity
K5706_RS21715	COG3842	ATPase activity
K5706_RS21735	COG3842	ATPase activity
K5706_RS21745	COG1175	transmembrane transport
K5706_RS21750	COG0395	ABC-type sugar transport system, permease component
K5706_RS21765	COG2017	converts alpha-aldose to the beta-anomer
K5706_RS21770	COG1472	Belongs to the glycosyl hydrolase 3 family
K5706_RS21805	COG0210	DNA helicase
K5706_RS22020	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K5706_RS22125	COG0210	DNA helicase
K5706_RS22230	COG0330	HflC and HflK could
K5706_RS22260	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
K5706_RS22345	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K5706_RS22365	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K5706_RS22370	COG1061	Type III restriction enzyme res subunit
K5706_RS22375	COG1002	Type II restriction enzyme, methylase subunits
K5706_RS22490	COG0561	phosphatase activity
K5706_RS22505	COG2160	L-arabinose isomerase activity
K5706_RS22510	COG0235	Class ii aldolase
K5706_RS22515	COG1069	ribulokinase activity
K5706_RS22520	COG1879	ABC-type sugar transport system periplasmic component
K5706_RS22525	COG1129	ABC transporter
K5706_RS22560	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K5706_RS22565	COG0840	transmembrane signaling receptor activity
K5706_RS22575	COG3335	DDE superfamily endonuclease
K5706_RS22585	COG1874	Beta-galactosidase
K5706_RS22595	COG3833	ABC-type maltose transport systems, permease component
K5706_RS22600	COG1175	transmembrane transport
K5706_RS22605	COG2182	Extracellular solute-binding protein
K5706_RS22615	COG1609	Transcriptional regulator
K5706_RS22650	COG3039	Transposase
K5706_RS22740	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K5706_RS22775	COG0640	Transcriptional regulator
K5706_RS23040	COG1192	Involved in chromosome partitioning
K5706_RS23180	COG1404	Belongs to the peptidase S8 family
K5706_RS23270	COG1793	dna ligase
K5706_RS23415	COG0714	Associated with various cellular activities
K5706_RS23455	COG4974	Belongs to the 'phage' integrase family
K5706_RS23780	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K5706_RS23900	COG2205	protein histidine kinase activity
K5706_RS23900	COG0784	Response regulator, receiver