locus-tag	class	description
D1115_RS00005	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
D1115_RS00025	COG0594	ribonuclease P activity
D1115_RS00035	COG1126	abc transporter atp-binding protein
D1115_RS00060	COG0592	DNA-directed DNA polymerase activity
D1115_RS00070	COG0187	DNA topoisomerase II activity
D1115_RS00075	COG0071	Belongs to the small heat shock protein (HSP20) family
D1115_RS00080	COG3977	Valine--pyruvate aminotransferase
D1115_RS00095	COG2119	membrane
D1115_RS00105	COG0425	Belongs to the sulfur carrier protein TusA family
D1115_RS00120	COG0604	alcohol dehydrogenase
D1115_RS00125	COG0183	Belongs to the thiolase family
D1115_RS00140	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D1115_RS00215	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D1115_RS00220	COG2104	thiamine diphosphate biosynthetic process
D1115_RS00235	COG0006	proline dipeptidase activity
D1115_RS00235	COG0006	proline dipeptidase activity
D1115_RS00245	COG2814	Major facilitator Superfamily
D1115_RS00265	COG3220	belongs to the UPF0276 family
D1115_RS00275	COG0210	DNA helicase
D1115_RS00285	COG0405	Gamma-glutamyltransferase
D1115_RS00290	COG1280	lysine exporter protein (LysE YggA)
D1115_RS00300	COG2962	Rard protein
D1115_RS00305	COG0514	ATP-dependent DNA helicase (RecQ)
D1115_RS00320	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
D1115_RS00325	COG0248	Ppx GppA phosphatase
D1115_RS00335	COG3118	belongs to the thioredoxin family
D1115_RS00350	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
D1115_RS00355	COG0633	Ferredoxin
D1115_RS00415	COG1587	Uroporphyrinogen-III synthase
D1115_RS00430	COG1965	Belongs to the frataxin family
D1115_RS00440	COG0019	diaminopimelate decarboxylase activity
D1115_RS00460	COG1011	Hydrolase
D1115_RS00465	COG3148	PFAM DTW domain containing protein
D1115_RS00480	COG0561	phosphatase activity
D1115_RS00485	COG2267	carboxylic ester hydrolase activity
D1115_RS00490	COG1280	lysine exporter protein (LysE YggA)
D1115_RS00495	COG0640	Transcriptional regulator
D1115_RS00500	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D1115_RS00555	COG0742	ribosomal rna small subunit methyltransferase
D1115_RS00565	COG2884	Cell division ATP-binding protein ftsE
D1115_RS00570	COG2177	Part of the ABC transporter FtsEX involved in
D1115_RS00585	COG0705	Rhomboid family
D1115_RS00590	COG1580	Controls the rotational direction of flagella during chemotaxis
D1115_RS00595	COG3161	chorismate lyase activity
D1115_RS00605	COG2937	Belongs to the GPAT DAPAT family
D1115_RS00625	COG0534	Mate efflux family protein
D1115_RS00630	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D1115_RS00710	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D1115_RS00720	COG1072	(Pantothenic acid kinase))
D1115_RS00760	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D1115_RS00765	COG0250	Participates in transcription elongation, termination and antitermination
D1115_RS00775	COG0081	regulation of translation
D1115_RS00780	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D1115_RS00795	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D1115_RS00800	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
D1115_RS00805	COG2816	NAD+ diphosphatase activity
D1115_RS00815	COG1573	uracil-dna glycosylase
D1115_RS00830	COG1253	flavin adenine dinucleotide binding
D1115_RS00845	COG0151	Belongs to the GarS family
D1115_RS00850	COG0138	bifunctional purine biosynthesis protein purh
D1115_RS00865	COG3710	Transcriptional regulator
D1115_RS00875	COG0531	amino acid
D1115_RS00880	COG1982	Orn Lys Arg decarboxylase major
D1115_RS00955	COG2199	diguanylate cyclase activity
D1115_RS00960	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
D1115_RS00965	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D1115_RS00975	COG0439	Biotin carboxylase
D1115_RS00980	COG0511	ligase activity, forming carbon-carbon bonds
D1115_RS00985	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
D1115_RS00990	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D1115_RS01005	COG2814	Major facilitator Superfamily
D1115_RS01010	COG0784	Response regulator, receiver
D1115_RS01010	COG2198	Histidine kinase
D1115_RS01010	COG2205	protein histidine kinase activity
D1115_RS01020	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D1115_RS01030	COG2095	MarC family integral membrane protein
D1115_RS01040	COG4232	protein-disulfide reductase activity
D1115_RS01045	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
D1115_RS01050	COG1027	Aspartate ammonia-lyase
D1115_RS01055	COG3030	protein affecting phage T7 exclusion by the F plasmid
D1115_RS01060	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D1115_RS01065	COG2205	protein histidine kinase activity
D1115_RS01070	COG0745	RESPONSE REGULATOR receiver
D1115_RS01075	COG3678	ATP-independent chaperone mediated protein folding
D1115_RS01090	COG0534	Mate efflux family protein
D1115_RS01120	COG1509	lysine 2,3-aminomutase activity
D1115_RS01140	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D1115_RS01145	COG1053	succinate dehydrogenase
D1115_RS01170	COG4942	peptidase
D1115_RS01175	COG1045	serine acetyltransferase
D1115_RS01190	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D1115_RS01195	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
D1115_RS01210	COG0471	metal ion transport
D1115_RS01225	COG1162	GTPase activity
D1115_RS01230	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
D1115_RS01310	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D1115_RS01315	COG0802	atpase or kinase
D1115_RS01340	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D1115_RS01345	COG0330	HflC and HflK could
D1115_RS01350	COG0330	HflC and HflK could
D1115_RS01355	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
D1115_RS01360	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D1115_RS01365	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
D1115_RS01370	COG1017	nitric oxide dioxygenase activity
D1115_RS01370	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D1115_RS01380	COG0557	exoribonuclease II activity
D1115_RS01385	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D1115_RS01390	COG0546	phosphoglycolate phosphatase activity
D1115_RS01400	COG0512	Glutamine amidotransferase of anthranilate synthase
D1115_RS01405	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D1115_RS01425	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D1115_RS01430	COG3954	Phosphoribulokinase
D1115_RS01435	COG3089	Belongs to the UPF0270 family
D1115_RS01440	COG0429	hydrolase of the alpha beta-hydrolase fold
D1115_RS01450	COG0488	(ABC) transporter
D1115_RS01455	COG2249	NAD(P)H dehydrogenase (quinone) activity
D1115_RS01470	COG1047	Peptidyl-prolyl cis-trans
D1115_RS01480	COG1446	asparaginase
D1115_RS01495	COG0545	Peptidyl-prolyl cis-trans isomerase
D1115_RS01500	COG2964	Protein conserved in bacteria
D1115_RS01505	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
D1115_RS01510	COG2923	Belongs to the DsrF TusC family
D1115_RS01530	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D1115_RS01540	COG2906	2 iron, 2 sulfur cluster binding
D1115_RS01550	COG0281	malic enzyme
D1115_RS01560	COG0626	cystathionine gamma-synthase activity
D1115_RS01565	COG0460	homoserine dehydrogenase
D1115_RS01565	COG0527	aspartate kinase activity
D1115_RS01570	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
D1115_RS01580	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
D1115_RS01590	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D1115_RS01605	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
D1115_RS01605	COG0165	Argininosuccinate lyase
D1115_RS01620	COG0678	peroxiredoxin activity
D1115_RS01620	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D1115_RS01630	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D1115_RS01675	COG0338	D12 class N6 adenine-specific DNA methyltransferase
D1115_RS01680	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D1115_RS01685	COG0360	Binds together with S18 to 16S ribosomal RNA
D1115_RS01690	COG2965	DNA replication, synthesis of RNA primer
D1115_RS01700	COG0359	binds to the 23S rRNA
D1115_RS01715	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D1115_RS01725	COG0432	Pfam Uncharacterised protein family UPF0047
D1115_RS01740	COG0735	belongs to the Fur family
D1115_RS01745	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D1115_RS01765	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
D1115_RS01830	COG3335	DDE superfamily endonuclease
D1115_RS01840	COG3335	DDE superfamily endonuclease
D1115_RS01855	COG0527	aspartate kinase activity
D1115_RS01865	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
D1115_RS01875	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D1115_RS01885	COG2197	response regulator
D1115_RS01890	COG0629	single-stranded DNA binding
D1115_RS01895	COG2200	EAL domain
D1115_RS01895	COG2199	diguanylate cyclase activity
D1115_RS01915	COG1450	Type ii and iii secretion system protein
D1115_RS01920	COG3409	Peptidoglycan-binding domain 1 protein
D1115_RS01920	COG3267	Type II secretory pathway component ExeA
D1115_RS01930	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D1115_RS01945	COG2165	general secretion pathway protein
D1115_RS01995	COG1077	Cell shape determining protein MreB Mrl
D1115_RS02000	COG1792	Involved in formation and maintenance of cell shape
D1115_RS02005	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
D1115_RS02010	COG0424	maF-like protein
D1115_RS02025	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D1115_RS02030	COG0312	modulator of DNA gyrase
D1115_RS02035	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
D1115_RS02040	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D1115_RS02045	COG0564	pseudouridine synthase activity
D1115_RS02050	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D1115_RS02055	COG3028	Belongs to the UPF0307 family
D1115_RS02060	COG0312	modulator of DNA gyrase
D1115_RS02065	COG2239	Acts as a magnesium transporter
D1115_RS02070	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D1115_RS02080	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D1115_RS02085	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D1115_RS02095	COG1137	ATPase activity
D1115_RS02100	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
D1115_RS02110	COG0517	IMP dehydrogenase activity
D1115_RS02110	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
D1115_RS02120	COG1127	ABC transporter
D1115_RS02125	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D1115_RS02130	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D1115_RS02135	COG2854	intermembrane phospholipid transfer
D1115_RS02145	COG5007	Belongs to the BolA IbaG family
D1115_RS02155	COG0204	Acyl-transferase
D1115_RS02160	COG0251	oxidation-reduction process
D1115_RS02200	COG0456	acetyltransferase
D1115_RS02210	COG0525	valine-tRNA ligase activity
D1115_RS02220	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D1115_RS02225	COG0795	lipopolysaccharide-transporting ATPase activity
D1115_RS02245	COG0582	viral genome integration into host DNA
D1115_RS02280	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
D1115_RS02285	COG0732	type I restriction modification DNA specificity domain
D1115_RS02300	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
D1115_RS02320	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D1115_RS02320	COG3153	acetyltransferase
D1115_RS02440	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
D1115_RS02445	COG1194	a g-specific adenine glycosylase
D1115_RS02465	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D1115_RS02470	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D1115_RS02485	COG0762	integral membrane protein
D1115_RS02490	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D1115_RS02495	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D1115_RS02510	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D1115_RS02515	COG1678	Uncharacterized ACR, COG1678
D1115_RS02520	COG0189	ligase activity
D1115_RS02525	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D1115_RS02530	COG2356	endonuclease I
D1115_RS02555	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D1115_RS02565	COG0126	phosphoglycerate kinase activity
D1115_RS02570	COG0191	fructose-bisphosphate aldolase activity
D1115_RS02575	COG0668	transmembrane transport
D1115_RS02590	COG0583	DNA-binding transcription factor activity
D1115_RS02600	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D1115_RS02610	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D1115_RS02620	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
D1115_RS02625	COG3079	Belongs to the UPF0149 family
D1115_RS02630	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D1115_RS02635	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D1115_RS02655	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
D1115_RS02665	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
D1115_RS02670	COG1595	DNA-templated transcription, initiation
D1115_RS02685	COG3086	response to oxidative stress
D1115_RS02705	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D1115_RS02710	COG1381	Involved in DNA repair and RecF pathway recombination
D1115_RS02715	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
D1115_RS02740	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D1115_RS02745	COG3956	TIGRFAM MazG family protein
D1115_RS02755	COG0148	phosphopyruvate hydratase activity
D1115_RS02765	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
D1115_RS02770	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
D1115_RS02795	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D1115_RS02805	COG1546	Belongs to the CinA family
D1115_RS02810	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
D1115_RS02825	COG0527	aspartate kinase activity
D1115_RS02920	COG3630	sodium ion export across plasma membrane
D1115_RS02925	COG5016	pyruvate
D1115_RS02925	COG0511	ligase activity, forming carbon-carbon bonds
D1115_RS02930	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
D1115_RS02940	COG1238	metal cluster binding
D1115_RS02945	COG0612	Peptidase, M16
D1115_RS02965	COG4536	flavin adenine dinucleotide binding
D1115_RS02970	COG4137	Cytochrome C assembly protein
D1115_RS02975	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D1115_RS03000	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
D1115_RS03005	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
D1115_RS03010	COG0237	dephospho-CoA kinase activity
D1115_RS03020	COG1459	type II secretion system
D1115_RS03025	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D1115_RS03045	COG2186	Transcriptional regulator
D1115_RS03050	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
D1115_RS03055	COG0508	dehydrogenase complex catalyzes the overall conversion of
D1115_RS03060	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D1115_RS03075	COG0288	reversible hydration of carbon dioxide
D1115_RS03080	COG0659	secondary active sulfate transmembrane transporter activity
D1115_RS03085	COG1131	(ABC) transporter
D1115_RS03090	COG0842	Transport permease protein
D1115_RS03105	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D1115_RS03115	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D1115_RS03125	COG1489	DNA binding
D1115_RS03130	COG1643	Atp-dependent helicase
D1115_RS03135	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D1115_RS03140	COG1752	Esterase of the alpha-beta hydrolase superfamily
D1115_RS03145	COG1049	propionate catabolic process, 2-methylcitrate cycle
D1115_RS03150	COG1929	Belongs to the glycerate kinase type-1 family
D1115_RS03155	COG2610	gluconate transmembrane transporter activity
D1115_RS03160	COG3835	regulator
D1115_RS03175	COG0004	ammonium transporteR
D1115_RS03180	COG1840	ABC-type Fe3 transport system, periplasmic component
D1115_RS03190	COG3842	ATPase activity
D1115_RS03195	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D1115_RS03210	COG2971	BadF BadG BcrA BcrD
D1115_RS03220	COG4608	Belongs to the ABC transporter superfamily
D1115_RS03225	COG0444	Belongs to the ABC transporter superfamily
D1115_RS03230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1115_RS03240	COG0747	negative chemotaxis
D1115_RS03265	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D1115_RS03270	COG0316	Belongs to the HesB IscA family
D1115_RS03285	COG0739	heme binding
D1115_RS03290	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D1115_RS03305	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
D1115_RS03310	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D1115_RS03315	COG1534	Rna-binding protein
D1115_RS03320	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
D1115_RS03325	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D1115_RS03335	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D1115_RS03350	COG0779	Required for maturation of 30S ribosomal subunits
D1115_RS03355	COG0195	Participates in both transcription termination and antitermination
D1115_RS03375	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
D1115_RS03380	COG1185	polyribonucleotide nucleotidyltransferase activity
D1115_RS03390	COG1846	Transcriptional regulator
D1115_RS03395	COG0534	Mate efflux family protein
D1115_RS03400	COG0826	peptidase U32
D1115_RS03405	COG0826	peptidase U32
D1115_RS03415	COG3154	lipid carrier protein
D1115_RS03420	COG3153	acetyltransferase
D1115_RS03445	COG0084	hydrolase, TatD family'
D1115_RS03450	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D1115_RS03460	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
D1115_RS03470	COG0813	purine-nucleoside phosphorylase activity
D1115_RS03490	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
D1115_RS03495	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D1115_RS03500	COG1022	Amp-dependent synthetase and ligase
D1115_RS03510	COG0583	DNA-binding transcription factor activity
D1115_RS03515	COG1609	Transcriptional regulator
D1115_RS03520	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D1115_RS03535	COG2017	converts alpha-aldose to the beta-anomer
D1115_RS03540	COG1609	Transcriptional regulator
D1115_RS03560	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D1115_RS03565	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D1115_RS03575	COG2171	N-acyltransferase activity
D1115_RS03590	COG3141	response to X-ray
D1115_RS03605	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
D1115_RS03610	COG1074	ATP-dependent DNA helicase activity
D1115_RS03615	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D1115_RS03680	COG0784	Response regulator, receiver
D1115_RS03680	COG2205	protein histidine kinase activity
D1115_RS03695	COG2204	response regulator
D1115_RS03700	COG5001	Diguanylate cyclase
D1115_RS03700	COG5002	protein histidine kinase activity
D1115_RS03770	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
D1115_RS03775	COG2166	iron-sulfur cluster assembly
D1115_RS03780	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D1115_RS03785	COG0693	protein deglycase activity
D1115_RS03790	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D1115_RS03795	COG3248	Nucleoside-binding outer membrane protein
D1115_RS03815	COG1595	DNA-templated transcription, initiation
D1115_RS03840	COG2813	Specifically methylates the guanine in position
D1115_RS03845	COG0271	Belongs to the BolA IbaG family
D1115_RS03870	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
D1115_RS03880	COG1477	protein flavinylation
D1115_RS03895	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D1115_RS03900	COG0514	ATP-dependent DNA helicase (RecQ)
D1115_RS03905	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D1115_RS03915	COG0733	neurotransmitter:sodium symporter activity
D1115_RS03940	COG1720	tRNA m6t6A37 methyltransferase activity
D1115_RS03945	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
D1115_RS03975	COG3098	single-species biofilm formation
D1115_RS03980	COG0564	pseudouridine synthase activity
D1115_RS03995	COG0024	Methionine aminopeptidase
D1115_RS04005	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D1115_RS04020	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D1115_RS04025	COG0575	Belongs to the CDS family
D1115_RS04035	COG0750	zinc metalloprotease
D1115_RS04045	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
D1115_RS04050	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D1115_RS04075	COG0587	DNA-directed DNA polymerase activity
D1115_RS04095	COG0347	Belongs to the P(II) protein family
D1115_RS04110	COG0741	lytic transglycosylase activity
D1115_RS04110	COG1388	LysM domain
D1115_RS04120	COG2226	methyltransferase
D1115_RS04130	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D1115_RS04145	COG1960	acyl-CoA dehydrogenase activity
D1115_RS04150	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
D1115_RS04155	COG0121	glutamine amidotransferase
D1115_RS04160	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D1115_RS04165	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D1115_RS04170	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D1115_RS04175	COG2233	PERMEase
D1115_RS04195	COG1393	Belongs to the ArsC family
D1115_RS04200	COG4783	chaperone-mediated protein folding
D1115_RS04215	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D1115_RS04220	COG2716	regulation of RNA biosynthetic process
D1115_RS04225	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D1115_RS04230	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
D1115_RS04250	COG1393	Belongs to the ArsC family
D1115_RS04275	COG2837	iron assimilation
D1115_RS04290	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D1115_RS04295	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D1115_RS04300	COG1334	flagellar protein FlaG
D1115_RS04305	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
D1115_RS04315	COG1516	flagellar protein fliS
D1115_RS04340	COG1677	Flagellar hook-basal body complex protein FliE
D1115_RS04350	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D1115_RS04395	COG1987	bacterial-type flagellum assembly
D1115_RS04400	COG1684	flagellar biosynthetic protein fliR
D1115_RS04435	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
D1115_RS04440	COG0643	Histidine kinase
D1115_RS04440	COG0784	Response regulator, receiver
D1115_RS04440	COG2198	Histidine kinase
D1115_RS04445	COG2201	protein-glutamate methylesterase activity
D1115_RS04450	COG1192	Involved in chromosome partitioning
D1115_RS04460	COG0835	chemotaxis
D1115_RS04470	COG4133	protoheme IX ABC transporter activity
D1115_RS04475	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D1115_RS04495	COG1138	Cytochrome C-type biogenesis protein
D1115_RS04500	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D1115_RS04510	COG3088	subunit of a heme lyase
D1115_RS04510	COG4235	cytochrome complex assembly
D1115_RS04515	COG2853	Lipoprotein
D1115_RS04525	COG2067	long-chain fatty acid transport protein
D1115_RS04550	COG1024	Enoyl-CoA hydratase
D1115_RS04550	COG1250	3-hydroxyacyl-CoA dehydrogenase
D1115_RS04565	COG2062	phosphohistidine phosphatase, SixA
D1115_RS04575	COG2890	protein-(glutamine-N5) methyltransferase activity
D1115_RS04580	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D1115_RS04585	COG2860	membrane
D1115_RS04590	COG3101	peptidyl-lysine hydroxylation
D1115_RS04610	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D1115_RS04620	COG0583	DNA-binding transcription factor activity
D1115_RS04625	COG4771	TonB-dependent receptor
D1115_RS04645	COG1263	PTS System
D1115_RS04645	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D1115_RS04650	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D1115_RS04655	COG1621	beta-fructofuranosidase activity
D1115_RS04660	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D1115_RS04665	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D1115_RS04685	COG0285	dihydrofolate synthase activity
D1115_RS04695	COG1286	toxin biosynthetic process
D1115_RS04700	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
D1115_RS04705	COG0583	DNA-binding transcription factor activity
D1115_RS04710	COG0745	RESPONSE REGULATOR receiver
D1115_RS04715	COG2832	Protein of unknown function (DUF454)
D1115_RS04725	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D1115_RS04730	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D1115_RS04735	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D1115_RS04740	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D1115_RS04750	COG2983	Belongs to the UPF0260 family
D1115_RS04755	COG2261	transglycosylase associated protein
D1115_RS04760	COG2985	domain, Protein
D1115_RS04765	COG0076	glutamate decarboxylase activity
D1115_RS04770	COG0668	transmembrane transport
D1115_RS04785	COG1522	sequence-specific DNA binding
D1115_RS04790	COG1946	Acyl-CoA thioesterase
D1115_RS04795	COG3126	Type III secretion system lipoprotein chaperone (YscW)
D1115_RS04810	COG3706	GGDEF domain
D1115_RS04820	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D1115_RS04825	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
D1115_RS04835	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
D1115_RS04840	COG0516	GMP reductase activity
D1115_RS04840	COG0517	IMP dehydrogenase activity
D1115_RS04870	COG0537	adenosine 5'-monophosphoramidase activity
D1115_RS04890	COG0510	thiamine kinase activity
D1115_RS04900	COG1252	NADH dehydrogenase
D1115_RS04915	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D1115_RS04925	COG4591	ABC-type transport system involved in lipoprotein release permease component
D1115_RS04930	COG1136	(ABC) transporter
D1115_RS04935	COG4591	ABC-type transport system involved in lipoprotein release permease component
D1115_RS04950	COG1132	(ABC) transporter
D1115_RS04970	COG2719	SpoVR family
D1115_RS04980	COG2766	serine protein kinase
D1115_RS04995	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D1115_RS05005	COG1882	Formate acetyltransferase
D1115_RS05040	COG0708	Exodeoxyribonuclease III
D1115_RS05050	COG3923	Primosomal replication protein n
D1115_RS05055	COG0730	response to heat
D1115_RS05060	COG1199	ATP-dependent helicase activity
D1115_RS05070	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
D1115_RS05075	COG1187	pseudouridine synthase activity
D1115_RS05085	COG1278	Cold shock
D1115_RS05095	COG0542	response to heat
D1115_RS05100	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D1115_RS05105	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
D1115_RS05130	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D1115_RS05140	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D1115_RS05145	COG0297	glycogen (starch) synthase activity
D1115_RS05165	COG3070	regulator of competence-specific genes
D1115_RS05175	COG3381	protein complex oligomerization
D1115_RS05180	COG0745	RESPONSE REGULATOR receiver
D1115_RS05185	COG1434	Gram-negative-bacterium-type cell wall biogenesis
D1115_RS05195	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
D1115_RS05200	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
D1115_RS05205	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
D1115_RS05230	COG0500	methyltransferase
D1115_RS05235	COG4106	trans-aconitate 2-methyltransferase activity
D1115_RS05240	COG1801	Protein of unknown function DUF72
D1115_RS05245	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D1115_RS05250	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
D1115_RS05255	COG0632	four-way junction helicase activity
D1115_RS05265	COG1271	oxidase subunit
D1115_RS05270	COG1294	oxidase, subunit
D1115_RS05275	COG4890	Cyd operon protein YbgT
D1115_RS05285	COG0824	Thioesterase
D1115_RS05290	COG0811	peptide transport
D1115_RS05305	COG0823	Involved in the tonB-independent uptake of proteins
D1115_RS05310	COG2885	chlorophyll binding
D1115_RS05315	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
D1115_RS05320	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
D1115_RS05335	COG5002	protein histidine kinase activity
D1115_RS05335	COG0784	Response regulator, receiver
D1115_RS05350	COG4584	PFAM Integrase catalytic
D1115_RS05355	COG1484	DNA-dependent DNA replication
D1115_RS05360	COG2020	methyltransferase activity
D1115_RS05390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D1115_RS05415	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D1115_RS05435	COG2176	DNA-directed DNA polymerase activity
D1115_RS05440	COG0517	IMP dehydrogenase activity
D1115_RS05445	COG2186	Transcriptional regulator
D1115_RS05450	COG2186	Transcriptional regulator
D1115_RS05455	COG0534	Mate efflux family protein
D1115_RS05460	COG2731	YhcH YjgK YiaL family protein
D1115_RS05475	COG1917	Cupin 2, conserved barrel domain protein
D1115_RS05480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D1115_RS05485	COG0800	Aldolase
D1115_RS05500	COG2084	Dehydrogenase
D1115_RS05515	COG0583	DNA-binding transcription factor activity
D1115_RS05525	COG0686	Belongs to the AlaDH PNT family
D1115_RS05540	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
D1115_RS05545	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D1115_RS05555	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D1115_RS05560	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D1115_RS05625	COG2268	Band 7 protein
D1115_RS05635	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D1115_RS05645	COG0482	sulfurtransferase activity
D1115_RS05655	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D1115_RS05665	COG1757	Na H antiporter
D1115_RS05675	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D1115_RS05685	COG0131	Imidazoleglycerol-phosphate dehydratase
D1115_RS05685	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D1115_RS05690	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
D1115_RS05695	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
D1115_RS05705	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D1115_RS05705	COG0140	phosphoribosyl-ATP diphosphatase activity
D1115_RS05720	COG3012	SEC-C Motif Domain Protein
D1115_RS05730	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D1115_RS05735	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D1115_RS05740	COG0215	cysteine-tRNA ligase activity
D1115_RS05745	COG1435	thymidine kinase activity
D1115_RS05750	COG1434	Gram-negative-bacterium-type cell wall biogenesis
D1115_RS05775	COG2116	formate transmembrane transporter activity
D1115_RS05780	COG0390	transport system, permease component
D1115_RS05785	COG4459	periplasmic nitrate reductase
D1115_RS05790	COG3005	denitrification pathway
D1115_RS05795	COG0243	molybdopterin cofactor binding
D1115_RS05810	COG1227	inorganic diphosphatase activity
D1115_RS05820	COG4172	Belongs to the ABC transporter superfamily
D1115_RS05830	COG4171	peptide transport system, permease
D1115_RS05835	COG4168	peptide transport system, permease
D1115_RS05845	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
D1115_RS05850	COG1842	Phage shock protein A
D1115_RS05870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D1115_RS05880	COG2818	Glycosylase
D1115_RS05885	COG0626	cystathionine gamma-synthase activity
D1115_RS05895	COG0733	neurotransmitter:sodium symporter activity
D1115_RS05905	COG0564	pseudouridine synthase activity
D1115_RS05915	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D1115_RS05920	COG1151	hydroxylamine reductase activity
D1115_RS05925	COG3604	Transcriptional regulator
D1115_RS05935	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D1115_RS05940	COG4136	ATPase activity
D1115_RS05945	COG4135	transport system, permease component
D1115_RS05950	COG4134	Bacterial extracellular solute-binding protein
D1115_RS05955	COG0398	Pfam SNARE associated Golgi protein
D1115_RS05965	COG0493	'glutamate synthase
D1115_RS05990	COG3313	Fe-S protein
D1115_RS06030	COG1187	pseudouridine synthase activity
D1115_RS06035	COG2814	Major facilitator Superfamily
D1115_RS06045	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D1115_RS06055	COG1609	Transcriptional regulator
D1115_RS06065	COG0534	Mate efflux family protein
D1115_RS06070	COG4181	ATPase activity
D1115_RS06095	COG1960	acyl-CoA dehydrogenase activity
D1115_RS06100	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D1115_RS06110	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D1115_RS06120	COG1737	Transcriptional regulator
D1115_RS06125	COG0076	glutamate decarboxylase activity
D1115_RS06135	COG2431	L-lysine efflux transmembrane transporter activity
D1115_RS06145	COG3070	regulator of competence-specific genes
D1115_RS06150	COG2801	Transposase and inactivated derivatives
D1115_RS06155	COG2963	transposase activity
D1115_RS06170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D1115_RS06170	COG4191	Histidine kinase
D1115_RS06180	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
D1115_RS06200	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
D1115_RS06205	COG4988	ABC transporter
D1115_RS06210	COG0492	ferredoxin-NADP+ reductase activity
D1115_RS06230	COG3706	GGDEF domain
D1115_RS06235	COG0471	metal ion transport
D1115_RS06260	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D1115_RS06295	COG0277	FAD linked oxidase domain protein
D1115_RS06295	COG0247	lactate metabolic process
D1115_RS06310	COG2986	histidine ammonia-lyase
D1115_RS06315	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
D1115_RS06345	COG1960	acyl-CoA dehydrogenase activity
D1115_RS06380	COG4245	von Willebrand factor, type A
D1115_RS06390	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
D1115_RS06560	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D1115_RS06570	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D1115_RS06580	COG0393	Putative heavy-metal-binding
D1115_RS06595	COG0072	phenylalanine-tRNA ligase activity
D1115_RS06595	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D1115_RS06625	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
D1115_RS06630	COG1643	Atp-dependent helicase
D1115_RS06640	COG0534	Mate efflux family protein
D1115_RS06645	COG2113	Glycine betaine
D1115_RS06650	COG4176	ABC-type proline glycine betaine transport system permease component
D1115_RS06670	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D1115_RS06675	COG0456	acetyltransferase
D1115_RS06680	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D1115_RS06685	COG0662	Cupin 2, conserved barrel domain protein
D1115_RS06695	COG0583	DNA-binding transcription factor activity
D1115_RS06700	COG0702	epimerase
D1115_RS06730	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D1115_RS06735	COG0363	glucosamine-6-phosphate deaminase activity
D1115_RS06740	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
D1115_RS06830	COG3284	Transcriptional regulator
D1115_RS06835	COG1012	belongs to the aldehyde dehydrogenase family
D1115_RS06845	COG2358	TRAP transporter, solute receptor (TAXI family
D1115_RS06850	COG0730	response to heat
D1115_RS06855	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
D1115_RS06860	COG2186	Transcriptional regulator
D1115_RS06865	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
D1115_RS06870	COG0372	Belongs to the citrate synthase family
D1115_RS06880	COG2828	Protein conserved in bacteria
D1115_RS06900	COG0561	phosphatase activity
D1115_RS06905	COG0602	queuosine metabolic process
D1115_RS06955	COG0840	transmembrane signaling receptor activity
D1115_RS06960	COG1254	Belongs to the acylphosphatase family
D1115_RS06965	COG2920	part of a sulfur-relay system
D1115_RS06970	COG0670	Belongs to the BI1 family
D1115_RS06975	COG1126	abc transporter atp-binding protein
D1115_RS06980	COG0765	amino acid transport
D1115_RS06985	COG4597	amino acid ABC transporter
D1115_RS06990	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D1115_RS07005	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D1115_RS07045	COG1132	(ABC) transporter
D1115_RS07055	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
D1115_RS07070	COG0308	aminopeptidase N
D1115_RS07085	COG0167	dihydroorotate dehydrogenase activity
D1115_RS07105	COG0488	(ABC) transporter
D1115_RS07125	COG1067	ATP-dependent peptidase activity
D1115_RS07130	COG3120	sequence-specific DNA binding
D1115_RS07180	COG3278	Belongs to the heme-copper respiratory oxidase family
D1115_RS07200	COG2217	Heavy metal translocating P-type atpase
D1115_RS07215	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D1115_RS07220	COG0589	response to stress
D1115_RS07245	COG3842	ATPase activity
D1115_RS07255	COG1177	transmembrane transport
D1115_RS07265	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D1115_RS07270	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D1115_RS07290	COG0437	4 iron, 4 sulfur cluster binding
D1115_RS07295	COG3383	formate dehydrogenase (NAD+) activity
D1115_RS07295	COG0243	molybdopterin cofactor binding
D1115_RS07325	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D1115_RS07350	COG4191	Histidine kinase
D1115_RS07355	COG2204	response regulator
D1115_RS07370	COG3842	ATPase activity
D1115_RS07380	COG0303	'Molybdopterin
D1115_RS07395	COG3148	PFAM DTW domain containing protein
D1115_RS07425	COG2201	protein-glutamate methylesterase activity
D1115_RS07430	COG3001	Fructosamine kinase
D1115_RS07440	COG0307	riboflavin synthase, alpha
D1115_RS07445	COG0534	Mate efflux family protein
D1115_RS07465	COG3064	Membrane
D1115_RS07490	COG3247	response to pH
D1115_RS07500	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
D1115_RS07580	COG0110	maltose O-acetyltransferase activity
D1115_RS07585	COG0438	transferase activity, transferring glycosyl groups
D1115_RS07605	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D1115_RS07630	COG0625	glutathione transferase activity
D1115_RS07640	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
D1115_RS07690	COG2195	Cleaves the N-terminal amino acid of tripeptides
D1115_RS07720	COG0583	DNA-binding transcription factor activity
D1115_RS07725	COG2814	Major facilitator Superfamily
D1115_RS07735	COG0583	DNA-binding transcription factor activity
D1115_RS07800	COG0813	purine-nucleoside phosphorylase activity
D1115_RS07805	COG1177	transmembrane transport
D1115_RS07815	COG3842	ATPase activity
D1115_RS07820	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D1115_RS07825	COG2423	ornithine cyclodeaminase activity
D1115_RS07835	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D1115_RS07840	COG3938	Belongs to the proline racemase family
D1115_RS07865	COG2205	protein histidine kinase activity
D1115_RS07865	COG0784	Response regulator, receiver
D1115_RS07880	COG1451	nucleotide metabolic process
D1115_RS07890	COG0583	DNA-binding transcription factor activity
D1115_RS07925	COG1115	amino acid carrier protein
D1115_RS07930	COG1280	lysine exporter protein (LysE YggA)
D1115_RS07935	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
D1115_RS07940	COG1560	Kdo2-lipid A biosynthetic process
D1115_RS07945	COG1280	lysine exporter protein (LysE YggA)
D1115_RS07950	COG0531	amino acid
D1115_RS07960	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
D1115_RS07965	COG3063	Type IV pilus biogenesis stability protein PilW
D1115_RS07975	COG4139	cobalamin transport
D1115_RS08000	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
D1115_RS08015	COG0702	epimerase
D1115_RS08025	COG2188	Transcriptional regulator
D1115_RS08030	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D1115_RS08030	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D1115_RS08030	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D1115_RS08035	COG0383	alpha-mannosidase activity
D1115_RS08040	COG1482	cell wall glycoprotein biosynthetic process
D1115_RS08070	COG0295	cytidine deaminase activity
D1115_RS08090	COG0776	regulation of translation
D1115_RS08100	COG2199	diguanylate cyclase activity
D1115_RS08110	COG0443	Heat shock 70 kDa protein
D1115_RS08115	COG0443	Heat shock 70 kDa protein
D1115_RS08130	COG1132	(ABC) transporter
D1115_RS08135	COG1132	(ABC) transporter
D1115_RS08150	COG3437	response regulator, receiver
D1115_RS08155	COG0814	amino acid
D1115_RS08170	COG0861	Integral membrane protein TerC family
D1115_RS08180	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D1115_RS08185	COG1328	CTP reductase activity
D1115_RS08200	COG5001	Diguanylate cyclase
D1115_RS08210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D1115_RS08210	COG4191	Histidine kinase
D1115_RS08235	COG2944	sequence-specific DNA binding
D1115_RS08240	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
D1115_RS08245	COG0346	lactoylglutathione lyase activity
D1115_RS08575	COG3340	Belongs to the peptidase S51 family
D1115_RS08795	COG0546	phosphoglycolate phosphatase activity
D1115_RS08815	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
D1115_RS08850	COG2026	Addiction module toxin, RelE StbE family
D1115_RS08865	COG0494	nUDIX hydrolase
D1115_RS09050	COG1028	Short-chain dehydrogenase reductase Sdr
D1115_RS09200	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D1115_RS09215	COG3106	COG3106 Predicted ATPase
D1115_RS09230	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D1115_RS09240	COG0814	amino acid
D1115_RS09245	COG1760	l-serine dehydratase
D1115_RS09255	COG0720	synthase
D1115_RS09260	COG0017	Asparaginyl-tRNA synthetase
D1115_RS09295	COG0840	transmembrane signaling receptor activity
D1115_RS09300	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D1115_RS09330	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D1115_RS09345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D1115_RS09350	COG3108	Peptidase M15
D1115_RS09360	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D1115_RS09380	COG2801	Transposase and inactivated derivatives
D1115_RS09385	COG2801	Transposase and inactivated derivatives
D1115_RS09390	COG2963	transposase activity
D1115_RS09400	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D1115_RS09410	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D1115_RS09415	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D1115_RS09435	COG0287	Prephenate dehydrogenase
D1115_RS09440	COG0019	diaminopimelate decarboxylase activity
D1115_RS09485	COG0322	excinuclease ABC activity
D1115_RS09490	COG2197	response regulator
D1115_RS09495	COG0417	DNA replication proofreading
D1115_RS09515	COG1187	pseudouridine synthase activity
D1115_RS09520	COG0009	L-threonylcarbamoyladenylate synthase
D1115_RS09525	COG0613	PHP domain protein
D1115_RS09535	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D1115_RS09540	COG0512	Glutamine amidotransferase of anthranilate synthase
D1115_RS09550	COG0135	phosphoribosylanthranilate isomerase activity
D1115_RS09550	COG0134	indole-3-glycerol-phosphate synthase activity
D1115_RS09560	COG0159	tryptophan synthase activity
D1115_RS09565	COG1301	dicarboxylic acid transport
D1115_RS09575	COG1607	acyl-coa hydrolase
D1115_RS09580	COG2350	Protein conserved in bacteria
D1115_RS09590	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D1115_RS09595	COG0583	DNA-binding transcription factor activity
D1115_RS09615	COG1032	radical SAM domain protein
D1115_RS09620	COG0446	pyridine nucleotide-disulphide oxidoreductase
D1115_RS09635	COG2964	Protein conserved in bacteria
D1115_RS09640	COG0840	transmembrane signaling receptor activity
D1115_RS09650	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
D1115_RS09655	COG0463	Glycosyl transferase, family 2
D1115_RS09665	COG3850	Histidine kinase
D1115_RS09665	COG5002	protein histidine kinase activity
D1115_RS09735	COG3118	belongs to the thioredoxin family
D1115_RS09740	COG4232	protein-disulfide reductase activity
D1115_RS09750	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
D1115_RS09755	COG2211	Major facilitator Superfamily
D1115_RS09775	COG3250	beta-galactosidase activity
D1115_RS09780	COG1609	Transcriptional regulator
D1115_RS09790	COG3008	intermembrane lipid transfer
D1115_RS09790	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D1115_RS09795	COG3009	Protein conserved in bacteria
D1115_RS09810	COG4166	transmembrane transport
D1115_RS09835	COG0539	negative regulation of cytoplasmic translation
D1115_RS09840	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D1115_RS09845	COG0616	signal peptide processing
D1115_RS09850	COG1028	Short-chain dehydrogenase reductase Sdr
D1115_RS09870	COG0784	Response regulator, receiver
D1115_RS09870	COG0835	chemotaxis
D1115_RS09875	COG1940	carbohydrate kinase activity
D1115_RS09905	COG1263	PTS System
D1115_RS09905	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D1115_RS09910	COG0084	hydrolase, TatD family'
D1115_RS09925	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D1115_RS09955	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D1115_RS09965	COG0333	Belongs to the bacterial ribosomal protein bL32 family
D1115_RS09970	COG1399	metal-binding, possibly nucleic acid-binding protein
D1115_RS09980	COG0564	pseudouridine synthase activity
D1115_RS09985	COG1530	ribonuclease E activity
D1115_RS09990	COG0659	secondary active sulfate transmembrane transporter activity
D1115_RS09995	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D1115_RS10000	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
D1115_RS10005	COG2982	Protein involved in outer membrane biogenesis
D1115_RS10010	COG0572	uridine kinase
D1115_RS10030	COG2186	Transcriptional regulator
D1115_RS10040	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
D1115_RS10045	COG0653	protein targeting
D1115_RS10050	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D1115_RS10065	COG1122	ATPase activity
D1115_RS10070	COG4120	Belongs to the binding-protein-dependent transport system permease family
D1115_RS10090	COG0857	belongs to the CobB CobQ family
D1115_RS10090	COG0280	phosphate acetyltransferase
D1115_RS10095	COG3174	membrane
D1115_RS10100	COG0435	Glutathione S-transferase
D1115_RS10120	COG0444	Belongs to the ABC transporter superfamily
D1115_RS10125	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1115_RS10130	COG0601	transmembrane transport
D1115_RS10140	COG0314	molybdopterin synthase activity
D1115_RS10145	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
D1115_RS10155	COG0521	Mo-molybdopterin cofactor biosynthetic process
D1115_RS10160	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D1115_RS10165	COG0391	Required for morphogenesis under gluconeogenic growth conditions
D1115_RS10170	COG2198	Histidine kinase
D1115_RS10175	COG2204	response regulator
D1115_RS10180	COG0556	nucleotide-excision repair
D1115_RS10190	COG1882	Formate acetyltransferase
D1115_RS10195	COG4657	Part of a membrane complex involved in electron transport
D1115_RS10205	COG4656	Part of a membrane complex involved in electron transport
D1115_RS10210	COG4658	electron transport chain
D1115_RS10220	COG4660	Part of a membrane complex involved in electron transport
D1115_RS10225	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D1115_RS10230	COG0346	lactoylglutathione lyase activity
D1115_RS10240	COG2885	chlorophyll binding
D1115_RS10250	COG2056	Na+-H+ antiporter family
D1115_RS10260	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
D1115_RS10285	COG2095	MarC family integral membrane protein
D1115_RS10290	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D1115_RS10300	COG1757	Na H antiporter
D1115_RS10340	COG0123	including yeast histone deacetylase and acetoin utilization protein
D1115_RS10345	COG4948	Mandelate Racemase Muconate Lactonizing
D1115_RS10355	COG2721	sulfolactate sulfo-lyase activity
D1115_RS10380	COG0778	Nitroreductase
D1115_RS10385	COG1902	pentaerythritol trinitrate reductase activity
D1115_RS10385	COG0446	pyridine nucleotide-disulphide oxidoreductase
D1115_RS10390	COG0616	signal peptide processing
D1115_RS10395	COG0252	asparaginase activity
D1115_RS10400	COG3139	Protein of unknown function (DUF1315)
D1115_RS10410	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D1115_RS10415	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D1115_RS10425	COG2226	methyltransferase
D1115_RS10445	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D1115_RS10450	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D1115_RS10505	COG2855	membrane
D1115_RS10525	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
D1115_RS10530	COG0596	Alpha beta hydrolase
D1115_RS10540	COG1169	isochorismate synthase
D1115_RS10545	COG0436	Aminotransferase
D1115_RS10570	COG1555	photosystem II stabilization
D1115_RS10575	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D1115_RS10580	COG0776	regulation of translation
D1115_RS10585	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D1115_RS10590	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D1115_RS10620	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D1115_RS10625	COG0569	domain protein
D1115_RS10630	COG0513	Belongs to the DEAD box helicase family
D1115_RS10650	COG0840	transmembrane signaling receptor activity
D1115_RS10655	COG0582	viral genome integration into host DNA
D1115_RS10765	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D1115_RS10775	COG2951	lytic endotransglycosylase activity
D1115_RS10790	COG2894	cell division
D1115_RS10795	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
D1115_RS10805	COG0318	PFAM AMP-dependent synthetase and ligase
D1115_RS10810	COG0596	Alpha beta hydrolase
D1115_RS10825	COG1214	PFAM Peptidase M22, glycoprotease
D1115_RS10830	COG1199	ATP-dependent helicase activity
D1115_RS10835	COG0788	formyltetrahydrofolate deformylase activity
D1115_RS10840	COG3102	Protein conserved in bacteria
D1115_RS10865	COG1918	ferrous iron import across plasma membrane
D1115_RS10875	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
D1115_RS10885	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D1115_RS10900	COG0508	dehydrogenase complex catalyzes the overall conversion of
D1115_RS10905	COG0567	Dehydrogenase, E1 component
D1115_RS10910	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D1115_RS10915	COG1053	succinate dehydrogenase
D1115_RS10920	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
D1115_RS10935	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D1115_RS10945	COG0033	Phosphoglucomutase
D1115_RS10950	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
D1115_RS10965	COG0716	FMN binding
D1115_RS10975	COG0735	belongs to the Fur family
D1115_RS10985	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D1115_RS10985	COG1263	PTS System
D1115_RS10985	COG2190	(PTS) system
D1115_RS10995	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
D1115_RS11005	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D1115_RS11005	COG4651	solute:proton antiporter activity
D1115_RS11010	COG0367	asparagine synthase
D1115_RS11020	COG3104	oligopeptide transport
D1115_RS11025	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
D1115_RS11040	COG3710	Transcriptional regulator
D1115_RS11060	COG0622	Phosphoesterase
D1115_RS11070	COG1090	epimerase
D1115_RS11075	COG0300	oxidoreductase activity
D1115_RS11085	COG3118	belongs to the thioredoxin family
D1115_RS11090	COG0330	HflC and HflK could
D1115_RS11095	COG1585	Membrane protein implicated in regulation of membrane protease activity
D1115_RS11120	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
D1115_RS11125	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D1115_RS11135	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D1115_RS11140	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D1115_RS11145	COG2190	(PTS) system
D1115_RS11150	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D1115_RS11155	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D1115_RS11170	COG3951	Flagellar rod assembly protein muramidase FlgJ
D1115_RS11170	COG1705	Flagellar rod assembly protein muramidase FlgJ
D1115_RS11175	COG1706	bacterial-type flagellum-dependent cell motility
D1115_RS11180	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
D1115_RS11190	COG4787	bacterial-type flagellum-dependent cell motility
D1115_RS11205	COG1558	bacterial-type flagellum-dependent cell motility
D1115_RS11210	COG1815	bacterial-type flagellum-dependent cell motility
D1115_RS11215	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D1115_RS11220	COG0784	Response regulator, receiver
D1115_RS11220	COG0835	chemotaxis
D1115_RS11270	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D1115_RS11315	COG2840	Smr protein MutS2
D1115_RS11320	COG1187	pseudouridine synthase activity
D1115_RS11325	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D1115_RS11330	COG0737	Belongs to the 5'-nucleotidase family
D1115_RS11340	COG2912	Transglutaminase-like superfamily
D1115_RS11345	COG3094	Invasion gene expression up-regulator, SirB
D1115_RS11350	COG2890	protein-(glutamine-N5) methyltransferase activity
D1115_RS11355	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D1115_RS11370	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
D1115_RS11375	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D1115_RS11495	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D1115_RS11505	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D1115_RS11510	COG1702	phosphate starvation-inducible protein PhoH
D1115_RS11520	COG4535	Mg2 and Co2 transporter CorC
D1115_RS11525	COG0815	Transfers the fatty acyl group on membrane lipoproteins
D1115_RS11530	COG2888	peptidyl-tyrosine sulfation
D1115_RS11535	COG0495	leucyl-tRNA aminoacylation
D1115_RS11540	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
D1115_RS11550	COG0799	negative regulation of ribosome biogenesis
D1115_RS11555	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
D1115_RS11560	COG0768	penicillin binding
D1115_RS11565	COG0772	Belongs to the SEDS family
D1115_RS11570	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D1115_RS11575	COG1686	Belongs to the peptidase S11 family
D1115_RS11595	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D1115_RS11600	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D1115_RS11605	COG0366	Alpha amylase catalytic
D1115_RS11610	COG1263	PTS System
D1115_RS11610	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D1115_RS11620	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D1115_RS11625	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D1115_RS11630	COG2011	ABC-type metal ion transport system permease component
D1115_RS11635	COG1464	Belongs to the NlpA lipoprotein family
D1115_RS11640	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
D1115_RS11665	COG1611	Belongs to the LOG family
D1115_RS11670	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D1115_RS11680	COG2363	Small membrane protein
D1115_RS11695	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D1115_RS11695	COG0301	tRNA thio-modification
D1115_RS11705	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D1115_RS11715	COG0142	geranyltranstransferase activity
D1115_RS11725	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
D1115_RS11730	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
D1115_RS11755	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D1115_RS11755	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D1115_RS11760	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D1115_RS11765	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D1115_RS11780	COG1073	alpha beta
D1115_RS11785	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
D1115_RS11790	COG2252	PERMEase
D1115_RS11800	COG2195	Cleaves the N-terminal amino acid of tripeptides
D1115_RS11820	COG0047	phosphoribosylformylglycinamidine synthase activity
D1115_RS11820	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D1115_RS11845	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
D1115_RS11875	COG0484	heat shock protein binding
D1115_RS11885	COG1301	dicarboxylic acid transport
D1115_RS11890	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D1115_RS11900	COG0497	DNA recombination
D1115_RS11905	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D1115_RS11910	COG2914	Belongs to the UPF0125 (RnfH) family
D1115_RS11915	COG2867	negative regulation of translational initiation
D1115_RS11930	COG0582	viral genome integration into host DNA
D1115_RS11965	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
D1115_RS12100	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D1115_RS12105	COG2873	o-acetylhomoserine
D1115_RS12110	COG0583	DNA-binding transcription factor activity
D1115_RS12120	COG1115	amino acid carrier protein
D1115_RS12125	COG1584	GPR1 FUN34 yaaH family protein
D1115_RS12135	COG0517	IMP dehydrogenase activity
D1115_RS12135	COG0516	GMP reductase activity
D1115_RS12160	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D1115_RS12165	COG2976	Protein conserved in bacteria
D1115_RS12170	COG0124	histidyl-tRNA synthetase
D1115_RS12200	COG2975	iron-sulfur cluster assembly
D1115_RS12205	COG0633	Ferredoxin
D1115_RS12220	COG0316	Belongs to the HesB IscA family
D1115_RS12225	COG0822	iron-sulfur transferase activity
D1115_RS12240	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
D1115_RS12245	COG0483	inositol monophosphate 1-phosphatase activity
D1115_RS12250	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D1115_RS12255	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D1115_RS12260	COG1862	Preprotein translocase
D1115_RS12265	COG0343	queuine tRNA-ribosyltransferase activity
D1115_RS12270	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
D1115_RS12280	COG0517	IMP dehydrogenase activity
D1115_RS12290	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D1115_RS12295	COG0583	DNA-binding transcription factor activity
D1115_RS12300	COG0450	alkyl hydroperoxide reductase
D1115_RS12330	COG0704	Plays a role in the regulation of phosphate uptake
D1115_RS12335	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D1115_RS12340	COG0581	inorganic phosphate transmembrane transporter activity
D1115_RS12355	COG0248	Ppx GppA phosphatase
D1115_RS12365	COG5002	protein histidine kinase activity
D1115_RS12370	COG0745	RESPONSE REGULATOR receiver
D1115_RS12380	COG2974	May be involved in recombination
D1115_RS12385	COG0826	peptidase U32
D1115_RS12390	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D1115_RS12450	COG0542	response to heat
D1115_RS12455	COG1496	oxidoreductase activity
D1115_RS12460	COG0564	pseudouridine synthase activity
D1115_RS12465	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D1115_RS12475	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D1115_RS12480	COG1605	Chorismate mutase
D1115_RS12480	COG0077	Prephenate dehydratase
D1115_RS12485	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
D1115_RS12500	COG0488	(ABC) transporter
D1115_RS12515	COG1605	Chorismate mutase
D1115_RS12515	COG0287	Prephenate dehydrogenase
D1115_RS12520	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D1115_RS12530	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
D1115_RS12550	COG1966	Carbon starvation protein
D1115_RS12555	COG3275	phosphorelay sensor kinase activity
D1115_RS12560	COG3279	Response regulator of the LytR AlgR family
D1115_RS12565	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
D1115_RS12570	COG1047	Peptidyl-prolyl cis-trans
D1115_RS12585	COG0196	riboflavin kinase activity
D1115_RS12590	COG0728	peptidoglycan biosynthetic process
D1115_RS12595	COG0268	Binds directly to 16S ribosomal RNA
D1115_RS12600	COG0640	Transcriptional regulator
D1115_RS12605	COG0583	DNA-binding transcription factor activity
D1115_RS12610	COG1283	sodium-dependent phosphate transmembrane transporter activity
D1115_RS12625	COG0730	response to heat
D1115_RS12645	COG3066	DNA modification
D1115_RS12655	COG0667	Aldo Keto reductase
D1115_RS12685	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D1115_RS12690	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D1115_RS12695	COG4974	Belongs to the 'phage' integrase family
D1115_RS12700	COG0716	FMN binding
D1115_RS12715	COG0513	Belongs to the DEAD box helicase family
D1115_RS12720	COG3022	response to hydroperoxide
D1115_RS12725	COG1115	amino acid carrier protein
D1115_RS12740	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D1115_RS12760	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
D1115_RS12765	COG0083	homoserine kinase activity
D1115_RS12780	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D1115_RS12805	COG2198	Histidine kinase
D1115_RS12805	COG5002	protein histidine kinase activity
D1115_RS12805	COG0784	Response regulator, receiver
D1115_RS12810	COG1242	4 iron, 4 sulfur cluster binding
D1115_RS12815	COG0067	glutamate synthase
D1115_RS12815	COG0070	glutamate synthase
D1115_RS12815	COG0069	glutamate synthase activity
D1115_RS12825	COG0070	glutamate synthase
D1115_RS12825	COG0069	glutamate synthase activity
D1115_RS12825	COG0067	glutamate synthase
D1115_RS12830	COG0493	'glutamate synthase
D1115_RS12855	COG2860	membrane
D1115_RS12860	COG0583	DNA-binding transcription factor activity
D1115_RS12865	COG0730	response to heat
D1115_RS12870	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D1115_RS12875	COG0505	Belongs to the CarA family
D1115_RS12885	COG0494	nUDIX hydrolase
D1115_RS12900	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
D1115_RS12905	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D1115_RS12910	COG0849	cell division
D1115_RS12915	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D1115_RS12930	COG0772	Belongs to the SEDS family
D1115_RS12940	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D1115_RS12945	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D1115_RS12950	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D1115_RS12955	COG0768	penicillin binding
D1115_RS12960	COG3116	cell division
D1115_RS12980	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D1115_RS12995	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
D1115_RS13000	COG2823	Periplasmic or secreted lipoprotein
D1115_RS13005	COG2969	positive regulation of protein catabolic process
D1115_RS13010	COG0625	glutathione transferase activity
D1115_RS13015	COG2857	Cytochrome c1
D1115_RS13020	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D1115_RS13025	COG0723	plastoquinol--plastocyanin reductase activity
D1115_RS13045	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
D1115_RS13050	COG3105	Protein conserved in bacteria
D1115_RS13065	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D1115_RS13075	COG3150	esterase
D1115_RS13085	COG3151	Protein conserved in bacteria
D1115_RS13090	COG0494	nUDIX hydrolase
D1115_RS13095	COG1538	Outer membrane efflux protein
D1115_RS13105	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
D1115_RS13115	COG3025	triphosphatase activity
D1115_RS13120	COG1392	Phosphate transport regulator
D1115_RS13125	COG0306	phosphate transporter
D1115_RS13130	COG4991	sh3 domain protein
D1115_RS13140	COG3267	Type II secretory pathway component ExeA
D1115_RS13140	COG3409	Peptidoglycan-binding domain 1 protein
D1115_RS13155	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D1115_RS13160	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D1115_RS13165	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
D1115_RS13170	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D1115_RS13175	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D1115_RS13180	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D1115_RS13185	COG1610	YqeY-like protein
D1115_RS13215	COG0730	response to heat
D1115_RS13250	COG3833	ABC-type maltose transport systems, permease component
D1115_RS13255	COG1175	transmembrane transport
D1115_RS13260	COG2182	Extracellular solute-binding protein
D1115_RS13270	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D1115_RS13275	COG3842	ATPase activity
D1115_RS13280	COG3119	arylsulfatase activity
D1115_RS13285	COG0641	radical SAM
D1115_RS13295	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D1115_RS13300	COG1349	DNA-binding transcription factor activity
D1115_RS13305	COG0469	pyruvate kinase activity
D1115_RS13325	COG0028	Belongs to the TPP enzyme family
D1115_RS13335	COG0583	DNA-binding transcription factor activity
D1115_RS13360	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D1115_RS13365	COG0473	3-isopropylmalate dehydrogenase activity
D1115_RS13385	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
D1115_RS13390	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
D1115_RS13395	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D1115_RS13410	COG2967	ApaG domain
D1115_RS13420	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D1115_RS13425	COG3610	response to peptide
D1115_RS13430	COG2966	Psort location CytoplasmicMembrane, score
D1115_RS13435	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D1115_RS13445	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D1115_RS13450	COG0142	geranyltranstransferase activity
D1115_RS13475	COG2358	TRAP transporter, solute receptor (TAXI family
D1115_RS13490	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
D1115_RS13495	COG1178	ABC-type Fe3 transport system permease component
D1115_RS13500	COG4143	(ABC) transporter
D1115_RS13505	COG0163	prenyltransferase activity
D1115_RS13510	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D1115_RS13515	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
D1115_RS13520	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
D1115_RS13525	COG2105	PFAM AIG2 family protein
D1115_RS13535	COG0729	surface antigen
D1115_RS13540	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D1115_RS13550	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
D1115_RS13565	COG4181	ATPase activity
D1115_RS13585	COG0529	Catalyzes the synthesis of activated sulfate
D1115_RS13590	COG3273	potassium ion transport
D1115_RS13590	COG0471	metal ion transport
D1115_RS13605	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D1115_RS13605	COG1648	precorrin-2 dehydrogenase activity
D1115_RS13610	COG0737	Belongs to the 5'-nucleotidase family
D1115_RS13620	COG0513	Belongs to the DEAD box helicase family
D1115_RS13625	COG2153	protein acetylation
D1115_RS13635	COG0545	Peptidyl-prolyl cis-trans isomerase
D1115_RS13645	COG0203	ribosomal protein L17
D1115_RS13650	COG0202	RNA polymerase activity
D1115_RS13660	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D1115_RS13665	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D1115_RS13675	COG0201	protein transport
D1115_RS13685	COG1841	ribosomal large subunit assembly
D1115_RS13700	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D1115_RS13710	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D1115_RS13715	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D1115_RS13720	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
D1115_RS13725	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D1115_RS13730	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D1115_RS13755	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D1115_RS13760	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D1115_RS13770	COG0088	Forms part of the polypeptide exit tunnel
D1115_RS13775	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D1115_RS13785	COG0254	rRNA binding
D1115_RS13790	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D1115_RS13795	COG1609	Transcriptional regulator
D1115_RS13820	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D1115_RS13825	COG3074	FtsZ-dependent cytokinesis
D1115_RS13830	COG1494	fructose-1,6-bisphosphatase
D1115_RS13860	COG0149	triose-phosphate isomerase activity
D1115_RS13885	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
D1115_RS13940	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D1115_RS13955	COG0438	transferase activity, transferring glycosyl groups
D1115_RS13965	COG1216	Glycosyl transferase, family 2
D1115_RS14000	COG0438	transferase activity, transferring glycosyl groups
D1115_RS14110	COG1028	Short-chain dehydrogenase reductase Sdr
D1115_RS14120	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D1115_RS14145	COG3642	lipopolysaccharide core region biosynthetic process
D1115_RS14150	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
D1115_RS14155	COG0859	PFAM glycosyl transferase family 9
D1115_RS14160	COG0463	Glycosyl transferase, family 2
D1115_RS14190	COG2194	sulfuric ester hydrolase activity
D1115_RS14200	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D1115_RS14210	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D1115_RS14225	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D1115_RS14230	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
D1115_RS14235	COG1561	YicC-like family, N-terminal region
D1115_RS14260	COG4608	Belongs to the ABC transporter superfamily
D1115_RS14265	COG0444	Belongs to the ABC transporter superfamily
D1115_RS14270	COG0747	negative chemotaxis
D1115_RS14275	COG4239	(ABC) transporter, permease
D1115_RS14280	COG4174	ABC transporter (Permease)
D1115_RS14300	COG0811	peptide transport
D1115_RS14305	COG0848	biopolymer transport protein
D1115_RS14320	COG0194	GDP metabolic process
D1115_RS14325	COG1758	RNA polymerase activity
D1115_RS14330	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D1115_RS14335	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D1115_RS14340	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D1115_RS14345	COG4946	Tricorn protease homolog
D1115_RS14345	COG1506	peptidase
D1115_RS14345	COG0823	Involved in the tonB-independent uptake of proteins
D1115_RS14350	COG2233	PERMEase
D1115_RS14375	COG2183	response to ionizing radiation
D1115_RS14390	COG1040	competence protein
D1115_RS14405	COG1218	3'(2'),5'-bisphosphate nucleotidase
D1115_RS14415	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
D1115_RS14420	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
D1115_RS14425	COG3156	type II secretion system protein K
D1115_RS14430	COG4795	General secretion pathway protein
D1115_RS14445	COG2165	general secretion pathway protein
D1115_RS14450	COG1459	type II secretion system
D1115_RS14455	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D1115_RS14470	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
D1115_RS14490	COG0456	acetyltransferase
D1115_RS14495	COG1490	D-aminoacyl-tRNA deacylase activity
D1115_RS14515	COG1217	gtp-binding protein TYPA
D1115_RS14520	COG0174	glutamine synthetase
D1115_RS14530	COG3852	Histidine kinase
D1115_RS14535	COG2204	response regulator
D1115_RS14545	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D1115_RS14580	COG0218	Necessary for normal cell division and for the maintenance of normal septation
D1115_RS14590	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D1115_RS14590	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D1115_RS14610	COG0084	hydrolase, TatD family'
D1115_RS14615	COG0805	protein transport
D1115_RS14620	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D1115_RS14635	COG3165	ubiquinone biosynthetic process from chorismate
D1115_RS14645	COG1322	Protein conserved in bacteria
D1115_RS14655	COG5001	Diguanylate cyclase
D1115_RS14655	COG3300	MHYT domain
D1115_RS14660	COG2081	HI0933 family
D1115_RS14670	COG1528	Iron-storage protein
D1115_RS14695	COG1522	sequence-specific DNA binding
D1115_RS14700	COG0339	signal peptide processing
D1115_RS14705	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
D1115_RS14710	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D1115_RS14715	COG0800	Aldolase
D1115_RS14720	COG2610	gluconate transmembrane transporter activity
D1115_RS14725	COG3265	gluconokinase activity
D1115_RS14730	COG0129	dihydroxy-acid dehydratase activity
D1115_RS14740	COG2076	Multidrug Resistance protein
D1115_RS14745	COG0583	DNA-binding transcription factor activity
D1115_RS14750	COG1609	Transcriptional regulator
D1115_RS14785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1115_RS14790	COG0601	transmembrane transport
D1115_RS14795	COG0747	negative chemotaxis
D1115_RS14850	COG1309	transcriptional regulator
D1115_RS14855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D1115_RS14860	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D1115_RS14870	COG2960	long-chain fatty acid transporting porin activity
D1115_RS14875	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D1115_RS14950	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D1115_RS14990	COG0569	domain protein
D1115_RS15005	COG1272	protein, Hemolysin III
D1115_RS15020	COG3084	Protein conserved in bacteria
D1115_RS15050	COG0606	chelatase, subunit chli
D1115_RS15060	COG3978	acetolactate synthase activity
D1115_RS15065	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D1115_RS15070	COG0129	dihydroxy-acid dehydratase activity
D1115_RS15085	COG2814	Major facilitator Superfamily
D1115_RS15095	COG0355	proton-transporting ATP synthase activity, rotational mechanism
D1115_RS15100	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
D1115_RS15105	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D1115_RS15110	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D1115_RS15120	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D1115_RS15135	COG3312	ion transport
D1115_RS15140	COG1475	DNA binding
D1115_RS15145	COG1192	Involved in chromosome partitioning
D1115_RS15155	COG0445	tRNA wobble uridine modification
D1115_RS15185	COG0772	Belongs to the SEDS family
D1115_RS15195	COG1566	PFAM secretion protein HlyD family protein
D1115_RS15200	COG0583	DNA-binding transcription factor activity
D1115_RS15210	COG1136	(ABC) transporter
D1115_RS15230	COG3275	phosphorelay sensor kinase activity
D1115_RS15235	COG3279	Response regulator of the LytR AlgR family
D1115_RS15245	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D1115_RS15265	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D1115_RS15270	COG1999	signal sequence binding
D1115_RS15310	COG0786	glutamate:sodium symporter activity
D1115_RS15320	COG1131	(ABC) transporter
D1115_RS15330	COG0786	glutamate:sodium symporter activity
D1115_RS15335	COG3119	arylsulfatase activity
D1115_RS15355	COG3119	arylsulfatase activity
D1115_RS15370	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D1115_RS15375	COG0800	Aldolase
D1115_RS15405	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D1115_RS15420	COG1566	PFAM secretion protein HlyD family protein
D1115_RS15475	COG3119	arylsulfatase activity
D1115_RS15480	COG1349	DNA-binding transcription factor activity
D1115_RS15495	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D1115_RS15500	COG3715	PTS system
D1115_RS15505	COG3716	PTS system mannose fructose sorbose family IID component
D1115_RS15510	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
D1115_RS15525	COG1028	Short-chain dehydrogenase reductase Sdr
D1115_RS15570	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
D1115_RS15575	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D1115_RS15585	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D1115_RS15615	COG3123	guanosine phosphorylase activity
D1115_RS15630	COG4932	domain protein
D1115_RS15630	COG4886	Leucine-rich repeat (LRR) protein
D1115_RS15645	COG2211	Major facilitator Superfamily
D1115_RS15685	COG0747	negative chemotaxis
D1115_RS15695	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D1115_RS15700	COG0444	Belongs to the ABC transporter superfamily
D1115_RS15705	COG4608	Belongs to the ABC transporter superfamily
D1115_RS15715	COG1609	Transcriptional regulator
D1115_RS15725	COG1609	Transcriptional regulator
D1115_RS15735	COG1472	Belongs to the glycosyl hydrolase 3 family
D1115_RS15740	COG0534	Mate efflux family protein
D1115_RS15745	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D1115_RS15750	COG0564	pseudouridine synthase activity
D1115_RS15755	COG0561	phosphatase activity
D1115_RS15765	COG2199	diguanylate cyclase activity
D1115_RS15775	COG3152	Membrane
D1115_RS15785	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
D1115_RS15790	COG2162	N-hydroxyarylamine O-acetyltransferase activity
D1115_RS15795	COG0583	DNA-binding transcription factor activity
D1115_RS15820	COG2076	Multidrug Resistance protein
D1115_RS15835	COG2358	TRAP transporter, solute receptor (TAXI family
D1115_RS15850	COG2814	Major facilitator Superfamily
D1115_RS15920	COG3005	denitrification pathway
D1115_RS15925	COG0243	molybdopterin cofactor binding
D1115_RS15945	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
D1115_RS15950	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D1115_RS15955	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D1115_RS15960	COG1116	anion transmembrane transporter activity
D1115_RS15965	COG0351	phosphomethylpyrimidine kinase
D1115_RS15970	COG0312	modulator of DNA gyrase
D1115_RS15975	COG0312	modulator of DNA gyrase
D1115_RS16040	COG4974	Belongs to the 'phage' integrase family
D1115_RS16130	COG0584	glycerophosphoryl diester phosphodiesterase
D1115_RS16135	COG0745	RESPONSE REGULATOR receiver
D1115_RS16155	COG0811	peptide transport
D1115_RS16160	COG0811	peptide transport
D1115_RS16165	COG0848	biopolymer transport protein
D1115_RS16190	COG1770	oligopeptidase
D1115_RS16195	COG2814	Major facilitator Superfamily
D1115_RS16200	COG0010	Belongs to the arginase family
D1115_RS16205	COG1166	arginine decarboxylase activity
D1115_RS16215	COG0189	ligase activity
D1115_RS16215	COG4067	protein conserved in archaea
D1115_RS16220	COG0189	ligase activity
D1115_RS16225	COG0583	DNA-binding transcription factor activity
D1115_RS16250	COG2204	response regulator
D1115_RS16260	COG1114	Component of the transport system for branched-chain amino acids
D1115_RS16275	COG0579	oxidoreductase
D1115_RS16290	COG3033	Beta-eliminating lyase
D1115_RS16310	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D1115_RS16335	COG3706	GGDEF domain
D1115_RS16340	COG0415	Belongs to the DNA photolyase family
D1115_RS16345	COG3046	protein related to deoxyribodipyrimidine photolyase
D1115_RS16360	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D1115_RS16360	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D1115_RS16365	COG1765	OsmC-like protein
D1115_RS16380	COG1011	Hydrolase
D1115_RS16400	COG3264	Mechanosensitive ion channel
D1115_RS16400	COG1511	domain protein
D1115_RS16405	COG2866	Carboxypeptidase
D1115_RS16425	COG3104	oligopeptide transport
D1115_RS16430	COG1760	l-serine dehydratase
D1115_RS16455	COG1388	LysM domain
D1115_RS16455	COG0741	lytic transglycosylase activity
D1115_RS16475	COG1815	bacterial-type flagellum-dependent cell motility
D1115_RS16480	COG1558	bacterial-type flagellum-dependent cell motility
D1115_RS16485	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
D1115_RS16500	COG4786	Flagellar basal body rod
D1115_RS16505	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
D1115_RS16510	COG1706	bacterial-type flagellum-dependent cell motility
D1115_RS16520	COG1256	bacterial-type flagellum assembly
D1115_RS16520	COG4786	Flagellar basal body rod
D1115_RS16590	COG1360	Flagellar Motor Protein
D1115_RS16595	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D1115_RS16600	COG1191	sigma factor activity
D1115_RS16605	COG1580	Controls the rotational direction of flagella during chemotaxis
D1115_RS16625	COG1516	flagellar protein fliS
D1115_RS16630	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
D1115_RS16645	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D1115_RS16670	COG1987	bacterial-type flagellum assembly
D1115_RS16700	COG1677	Flagellar hook-basal body complex protein FliE
D1115_RS16790	COG0156	8-amino-7-oxononanoate synthase activity
D1115_RS16795	COG1063	alcohol dehydrogenase
D1115_RS16800	COG0582	viral genome integration into host DNA
D1115_RS16855	COG3335	DDE superfamily endonuclease
D1115_RS16875	COG1349	DNA-binding transcription factor activity
D1115_RS16880	COG2084	Dehydrogenase
D1115_RS16885	COG3395	kinase activity
D1115_RS16890	COG0235	Class ii aldolase
D1115_RS16895	COG3622	Belongs to the hyi family
D1115_RS16900	COG2610	gluconate transmembrane transporter activity
D1115_RS16910	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D1115_RS16915	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D1115_RS16920	COG2356	endonuclease I
D1115_RS16980	COG1063	alcohol dehydrogenase
D1115_RS16995	COG0668	transmembrane transport
D1115_RS17005	COG1304	FMN binding
D1115_RS17010	COG0583	DNA-binding transcription factor activity
D1115_RS17020	COG1067	ATP-dependent peptidase activity
D1115_RS17040	COG0437	4 iron, 4 sulfur cluster binding
D1115_RS17045	COG0348	domain, Protein
D1115_RS17050	COG0640	Transcriptional regulator
D1115_RS17075	COG1566	PFAM secretion protein HlyD family protein
D1115_RS17105	COG0813	purine-nucleoside phosphorylase activity
D1115_RS17110	COG3272	Protein of unknown function (DUF1722)
D1115_RS17120	COG0415	Belongs to the DNA photolyase family
D1115_RS17125	COG1376	ErfK ybiS ycfS ynhG family protein
D1115_RS17125	COG1388	LysM domain
D1115_RS17135	COG0513	Belongs to the DEAD box helicase family
D1115_RS17145	COG0573	inorganic phosphate transmembrane transporter activity
D1115_RS17150	COG0581	inorganic phosphate transmembrane transporter activity
D1115_RS17155	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D1115_RS17160	COG3706	GGDEF domain
D1115_RS17190	COG0714	Associated with various cellular activities
D1115_RS17195	COG0840	transmembrane signaling receptor activity
D1115_RS17210	COG0110	maltose O-acetyltransferase activity
D1115_RS17215	COG1028	Short-chain dehydrogenase reductase Sdr
D1115_RS17220	COG5001	Diguanylate cyclase
D1115_RS17220	COG2203	Gaf domain
D1115_RS17220	COG4251	negative regulation of phosphorylation
D1115_RS17220	COG3706	GGDEF domain
D1115_RS17245	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D1115_RS17250	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D1115_RS17255	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
D1115_RS17270	COG1252	NADH dehydrogenase
D1115_RS17275	COG1301	dicarboxylic acid transport
D1115_RS17280	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D1115_RS17285	COG2706	6-phosphogluconolactonase activity
D1115_RS17290	COG1881	PFAM PEBP family protein
D1115_RS17300	COG0798	PFAM Bile acid sodium symporter
D1115_RS17310	COG0814	amino acid
D1115_RS17320	COG3314	Sporulation integral membrane protein YlbJ
D1115_RS17345	COG0739	heme binding
D1115_RS17355	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D1115_RS17360	COG0697	spore germination
D1115_RS17375	COG0179	Fumarylacetoacetate (FAA) hydrolase
D1115_RS17380	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
D1115_RS17385	COG1280	lysine exporter protein (LysE YggA)
D1115_RS17390	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D1115_RS17395	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D1115_RS17395	COG1565	acr, cog1565
D1115_RS17405	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
D1115_RS17410	COG1845	cytochrome c oxidase, subunit III
D1115_RS17430	COG1612	heme a metabolic process
D1115_RS17450	COG0840	transmembrane signaling receptor activity
D1115_RS17455	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D1115_RS17480	COG2897	thiosulfate sulfurtransferase activity
D1115_RS17505	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D1115_RS17510	COG0303	'Molybdopterin
D1115_RS17520	COG1914	H( )-stimulated, divalent metal cation uptake system
D1115_RS17545	COG4989	oxidoreductase activity
D1115_RS17560	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D1115_RS17560	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
D1115_RS17570	COG1247	-acetyltransferase
D1115_RS17585	COG1566	PFAM secretion protein HlyD family protein
D1115_RS17595	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D1115_RS17600	COG0076	glutamate decarboxylase activity
D1115_RS17630	COG4176	ABC-type proline glycine betaine transport system permease component
D1115_RS17635	COG0517	IMP dehydrogenase activity
D1115_RS17635	COG4175	Glycine betaine
D1115_RS17660	COG3300	MHYT domain
D1115_RS17660	COG5001	Diguanylate cyclase
D1115_RS17780	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
D1115_RS17840	COG1794	racemase activity, acting on amino acids and derivatives
D1115_RS17845	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D1115_RS17860	COG0738	Major facilitator superfamily
D1115_RS17870	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D1115_RS17885	COG0789	Transcriptional regulator
D1115_RS17910	COG1289	transmembrane transporter activity
D1115_RS17925	COG1879	ABC-type sugar transport system periplasmic component
D1115_RS17930	COG2205	protein histidine kinase activity
D1115_RS17930	COG0784	Response regulator, receiver
D1115_RS17930	COG2198	Histidine kinase
D1115_RS17945	COG3119	arylsulfatase activity
D1115_RS17950	COG3119	arylsulfatase activity
D1115_RS17955	COG3063	Type IV pilus biogenesis stability protein PilW
D1115_RS17960	COG0714	Associated with various cellular activities
D1115_RS17995	COG0583	DNA-binding transcription factor activity
D1115_RS18000	COG3111	PFAM Bacterial OB fold (BOF) protein
D1115_RS18020	COG0641	radical SAM
D1115_RS18045	COG3069	C4-dicarboxylate transmembrane transporter activity
D1115_RS18065	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
D1115_RS18120	COG0778	Nitroreductase
D1115_RS18125	COG0784	Response regulator, receiver
D1115_RS18125	COG0835	chemotaxis
D1115_RS18135	COG2165	general secretion pathway protein
D1115_RS18145	COG2962	Rard protein
D1115_RS18160	COG0671	phosphoesterase, PA-phosphatase related
D1115_RS18190	COG1902	pentaerythritol trinitrate reductase activity
D1115_RS18195	COG0346	lactoylglutathione lyase activity
D1115_RS18200	COG0420	3'-5' exonuclease activity
D1115_RS18205	COG0419	ATPase involved in DNA repair
D1115_RS18215	COG3469	chitinase activity
D1115_RS18235	COG3040	lipid binding
D1115_RS18255	COG2249	NAD(P)H dehydrogenase (quinone) activity
D1115_RS18315	COG0509	glycine decarboxylation via glycine cleavage system
D1115_RS18320	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D1115_RS18360	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
D1115_RS18360	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D1115_RS18360	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D1115_RS18365	COG1105	Belongs to the carbohydrate kinase PfkB family
D1115_RS18370	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D1115_RS18370	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
D1115_RS18375	COG1609	Transcriptional regulator
D1115_RS18390	COG0765	amino acid transport
D1115_RS18395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D1115_RS18400	COG0765	amino acid transport
D1115_RS18405	COG1126	abc transporter atp-binding protein
D1115_RS18410	COG1979	alcohol dehydrogenase
D1115_RS18415	COG2207	Transcriptional regulator
D1115_RS18430	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D1115_RS18460	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
D1115_RS18465	COG0513	Belongs to the DEAD box helicase family
D1115_RS18480	COG3038	cytochrome b561
D1115_RS18490	COG2116	formate transmembrane transporter activity
D1115_RS18495	COG0583	DNA-binding transcription factor activity
D1115_RS18505	COG3593	DNA synthesis involved in DNA repair
D1115_RS18510	COG0737	Belongs to the 5'-nucleotidase family
D1115_RS18515	COG0861	Integral membrane protein TerC family
D1115_RS18535	COG2267	carboxylic ester hydrolase activity
D1115_RS18540	COG2067	long-chain fatty acid transport protein
D1115_RS18555	COG2050	protein possibly involved in aromatic compounds catabolism
D1115_RS18565	COG4533	DNA binding
D1115_RS18590	COG0484	heat shock protein binding
D1115_RS18605	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D1115_RS18620	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
D1115_RS18630	COG1984	allophanate hydrolase subunit 2
D1115_RS18635	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
D1115_RS18645	COG3447	MASE1 domain protein
D1115_RS18645	COG5002	protein histidine kinase activity
D1115_RS18645	COG5001	Diguanylate cyclase
D1115_RS18665	COG0583	DNA-binding transcription factor activity
D1115_RS18670	COG0045	succinate-CoA ligase (ADP-forming) activity
D1115_RS18670	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D1115_RS18670	COG1042	CoA-binding domain protein
D1115_RS18690	COG0023	Translation Initiation Factor
D1115_RS18695	COG3140	Belongs to the UPF0181 family
D1115_RS18720	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
D1115_RS18725	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
D1115_RS18750	COG2203	Gaf domain
D1115_RS18750	COG3706	GGDEF domain
D1115_RS18750	COG4251	negative regulation of phosphorylation
D1115_RS18750	COG5001	Diguanylate cyclase
D1115_RS18760	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
D1115_RS18765	COG4149	molybdate abc transporter
D1115_RS18770	COG0725	ABC transporter, periplasmic molybdate-binding protein
D1115_RS18780	COG3111	PFAM Bacterial OB fold (BOF) protein
D1115_RS18805	COG0534	Mate efflux family protein
D1115_RS18810	COG0602	queuosine metabolic process
D1115_RS18815	COG1328	CTP reductase activity
D1115_RS18890	COG0628	permease
D1115_RS18900	COG1566	PFAM secretion protein HlyD family protein
D1115_RS18915	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D1115_RS18920	COG3118	belongs to the thioredoxin family
D1115_RS18960	COG2116	formate transmembrane transporter activity
D1115_RS18970	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D1115_RS18975	COG3706	GGDEF domain
D1115_RS19025	COG0277	FAD linked oxidase domain protein
D1115_RS19035	COG2425	protein containing a von Willebrand factor type A (vWA) domain
D1115_RS19050	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
D1115_RS19060	COG1288	antiporter activity
D1115_RS19115	COG2826	transposase and inactivated derivatives, IS30 family
D1115_RS19170	COG1132	(ABC) transporter
D1115_RS19205	COG0318	PFAM AMP-dependent synthetase and ligase
D1115_RS19215	COG4771	TonB-dependent receptor
D1115_RS19240	COG0628	permease
D1115_RS19280	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D1115_RS19280	COG2146	nitrite reductase [NAD(P)H] activity
D1115_RS19285	COG1116	anion transmembrane transporter activity
D1115_RS19290	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D1115_RS19295	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D1115_RS19295	COG1116	anion transmembrane transporter activity
D1115_RS19305	COG3707	response regulator
D1115_RS19320	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D1115_RS19320	COG1648	precorrin-2 dehydrogenase activity
D1115_RS19325	COG0243	molybdopterin cofactor binding
D1115_RS19335	COG0814	amino acid
D1115_RS19360	COG1785	Belongs to the alkaline phosphatase family
D1115_RS19365	COG5002	protein histidine kinase activity
D1115_RS19370	COG0745	RESPONSE REGULATOR receiver
D1115_RS19390	COG0443	Heat shock 70 kDa protein
D1115_RS19405	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D1115_RS19440	COG3976	FMN-binding domain protein
D1115_RS19440	COG0431	NADPH-dependent FMN reductase
D1115_RS19440	COG1053	succinate dehydrogenase
D1115_RS19445	COG0625	glutathione transferase activity
D1115_RS19465	COG4160	amino acid transport
D1115_RS19470	COG4215	(ABC) transporter
D1115_RS19475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D1115_RS19480	COG1126	abc transporter atp-binding protein
D1115_RS19495	COG1902	pentaerythritol trinitrate reductase activity
D1115_RS19495	COG0446	pyridine nucleotide-disulphide oxidoreductase
D1115_RS19510	COG1024	Enoyl-CoA hydratase
D1115_RS19515	COG1024	Enoyl-CoA hydratase
D1115_RS19520	COG1960	acyl-CoA dehydrogenase activity
D1115_RS19535	COG1960	acyl-CoA dehydrogenase activity
D1115_RS19540	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D1115_RS19545	COG1024	Enoyl-CoA hydratase
D1115_RS19565	COG3278	Belongs to the heme-copper respiratory oxidase family
D1115_RS19645	COG0444	Belongs to the ABC transporter superfamily
D1115_RS19665	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D1115_RS19690	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
D1115_RS19735	COG3706	GGDEF domain
D1115_RS19740	COG2252	PERMEase
D1115_RS19745	COG1119	ATPase activity
D1115_RS19765	COG0513	Belongs to the DEAD box helicase family
D1115_RS19805	COG3416	Protein conserved in bacteria
D1115_RS19820	COG3530	Putative quorum-sensing-regulated virulence factor
D1115_RS19850	COG3186	Phenylalanine-4-hydroxylase
D1115_RS19855	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D1115_RS19860	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D1115_RS19880	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
D1115_RS19885	COG1454	alcohol dehydrogenase
D1115_RS19890	COG2133	pyrroloquinoline quinone binding
D1115_RS19900	COG0783	Belongs to the Dps family
D1115_RS19905	COG0840	transmembrane signaling receptor activity
D1115_RS19915	COG0577	efflux transmembrane transporter activity
D1115_RS19915	COG1136	(ABC) transporter
D1115_RS19920	COG1136	(ABC) transporter
D1115_RS19920	COG0577	efflux transmembrane transporter activity
D1115_RS19935	COG1278	Cold shock
D1115_RS19965	COG0545	Peptidyl-prolyl cis-trans isomerase
D1115_RS19990	COG2197	response regulator
D1115_RS19995	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D1115_RS20005	COG0840	transmembrane signaling receptor activity
D1115_RS20025	COG2195	Cleaves the N-terminal amino acid of tripeptides
D1115_RS20040	COG2197	response regulator
D1115_RS20045	COG3850	Histidine kinase
D1115_RS20050	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D1115_RS20070	COG3005	denitrification pathway
D1115_RS20090	COG0183	Belongs to the thiolase family
D1115_RS20100	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D1115_RS20105	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D1115_RS20145	COG2827	Endonuclease containing a URI domain
D1115_RS20165	COG0534	Mate efflux family protein
D1115_RS20190	COG0583	DNA-binding transcription factor activity
D1115_RS20225	COG1566	PFAM secretion protein HlyD family protein
D1115_RS20230	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D1115_RS20235	COG2239	Acts as a magnesium transporter
D1115_RS20240	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
D1115_RS20245	COG0402	S-adenosylhomocysteine deaminase activity
D1115_RS20260	COG1418	mRNA catabolic process
D1115_RS20270	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D1115_RS20285	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D1115_RS20300	COG4221	oxidoreductase activity
D1115_RS20305	COG0745	RESPONSE REGULATOR receiver
D1115_RS20310	COG2205	protein histidine kinase activity
D1115_RS20320	COG2194	sulfuric ester hydrolase activity
D1115_RS20335	COG2814	Major facilitator Superfamily
D1115_RS20350	COG2249	NAD(P)H dehydrogenase (quinone) activity
D1115_RS20365	COG0583	DNA-binding transcription factor activity
D1115_RS20390	COG0366	Alpha amylase catalytic
D1115_RS20395	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D1115_RS20400	COG0835	chemotaxis
D1115_RS20400	COG0784	Response regulator, receiver
D1115_RS20410	COG0748	coenzyme F420 binding
D1115_RS20430	COG0811	peptide transport
D1115_RS20435	COG0848	biopolymer transport protein
D1115_RS20445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D1115_RS20450	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
D1115_RS20490	COG2186	Transcriptional regulator
D1115_RS20510	COG3217	Mosc domain protein beta barrel domain protein
D1115_RS20510	COG0633	Ferredoxin
D1115_RS20510	COG0633	Ferredoxin
D1115_RS20510	COG3217	Mosc domain protein beta barrel domain protein
D1115_RS20515	COG0401	homolog of Blt101
D1115_RS20530	COG2354	Protein conserved in bacteria
D1115_RS20610	COG0741	lytic transglycosylase activity
D1115_RS20655	COG3833	ABC-type maltose transport systems, permease component
D1115_RS20660	COG1175	transmembrane transport
D1115_RS20675	COG3842	ATPase activity
D1115_RS20685	COG1309	transcriptional regulator
D1115_RS20690	COG2130	NADP-dependent
D1115_RS20700	COG0753	catalase activity
D1115_RS20705	COG2084	Dehydrogenase
D1115_RS20715	COG0583	DNA-binding transcription factor activity
D1115_RS20720	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D1115_RS20725	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D1115_RS20735	COG2207	Transcriptional regulator
D1115_RS20740	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D1115_RS20740	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D1115_RS20740	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D1115_RS20745	COG1482	cell wall glycoprotein biosynthetic process
D1115_RS20760	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
D1115_RS20770	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D1115_RS20775	COG2249	NAD(P)H dehydrogenase (quinone) activity
D1115_RS20785	COG0402	S-adenosylhomocysteine deaminase activity
D1115_RS20800	COG3383	formate dehydrogenase (NAD+) activity
D1115_RS20820	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D1115_RS20845	COG0604	alcohol dehydrogenase
D1115_RS20845	COG1028	Short-chain dehydrogenase reductase Sdr
D1115_RS20845	COG3321	synthase
D1115_RS20850	COG0456	acetyltransferase
D1115_RS20860	COG0494	nUDIX hydrolase
D1115_RS20865	COG1505	serine-type exopeptidase activity
D1115_RS20875	COG0589	response to stress
D1115_RS20915	COG4667	esterase of the alpha-beta hydrolase superfamily
D1115_RS20920	COG1741	Belongs to the pirin family
D1115_RS20925	COG1278	Cold shock
D1115_RS20940	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D1115_RS20940	COG0678	peroxiredoxin activity
D1115_RS20950	COG1686	Belongs to the peptidase S11 family
D1115_RS20955	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D1115_RS20960	COG0625	glutathione transferase activity
D1115_RS20970	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D1115_RS20975	COG1028	Short-chain dehydrogenase reductase Sdr
D1115_RS20990	COG1028	Short-chain dehydrogenase reductase Sdr
D1115_RS21000	COG0583	DNA-binding transcription factor activity
D1115_RS21005	COG2207	Transcriptional regulator
D1115_RS21005	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D1115_RS21010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D1115_RS21035	COG0513	Belongs to the DEAD box helicase family
D1115_RS21055	COG0589	response to stress
D1115_RS21060	COG3122	Protein conserved in bacteria
D1115_RS21075	COG0583	DNA-binding transcription factor activity
D1115_RS21080	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D1115_RS21085	COG1335	isochorismatase
D1115_RS21090	COG1881	PFAM PEBP family protein
D1115_RS21110	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
D1115_RS21115	COG0574	Belongs to the PEP-utilizing enzyme family
D1115_RS21115	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D1115_RS21125	COG3302	dmso reductase anchor subunit
D1115_RS21130	COG0437	4 iron, 4 sulfur cluster binding
D1115_RS21135	COG0243	molybdopterin cofactor binding
D1115_RS21140	COG3381	protein complex oligomerization
D1115_RS21155	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D1115_RS21170	COG0786	glutamate:sodium symporter activity
D1115_RS21185	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D1115_RS21225	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D1115_RS21260	COG3710	Transcriptional regulator
D1115_RS21270	COG3710	Transcriptional regulator
D1115_RS21290	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D1115_RS21310	COG1342	Belongs to the UPF0251 family
D1115_RS21320	COG4176	ABC-type proline glycine betaine transport system permease component
D1115_RS21325	COG4175	Glycine betaine
D1115_RS21325	COG3448	diguanylate cyclase activity
D1115_RS21330	COG3015	lipoprotein NlpE involved in copper resistance
D1115_RS21335	COG0583	DNA-binding transcription factor activity
D1115_RS21395	COG0346	lactoylglutathione lyase activity
D1115_RS21410	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D1115_RS21415	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D1115_RS21420	COG0583	DNA-binding transcription factor activity
D1115_RS21440	COG4628	conserved protein (DUF2132)
D1115_RS21445	COG0488	(ABC) transporter
D1115_RS21480	COG0628	permease
D1115_RS21485	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
D1115_RS21495	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D1115_RS21510	COG4628	conserved protein (DUF2132)
D1115_RS21515	COG0583	DNA-binding transcription factor activity
D1115_RS21525	COG0583	DNA-binding transcription factor activity
D1115_RS21535	COG1234	tRNA 3'-trailer cleavage
D1115_RS21550	COG1686	Belongs to the peptidase S11 family
D1115_RS21565	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
D1115_RS21575	COG3397	chitin binding
D1115_RS21590	COG0840	transmembrane signaling receptor activity
D1115_RS21595	COG4667	esterase of the alpha-beta hydrolase superfamily
D1115_RS21600	COG2095	MarC family integral membrane protein
D1115_RS21605	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D1115_RS21650	COG1301	dicarboxylic acid transport
D1115_RS21655	COG3339	Conserved Protein
D1115_RS21660	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D1115_RS21665	COG0700	Nucleoside recognition
D1115_RS21670	COG3366	ferrous iron transmembrane transporter activity
D1115_RS21675	COG0366	Alpha amylase catalytic
D1115_RS21680	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D1115_RS21685	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D1115_RS21690	COG1640	4-alpha-glucanotransferase
D1115_RS21695	COG0058	SHG alpha-glucan phosphorylase activity
D1115_RS21730	COG1263	PTS System
D1115_RS21730	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D1115_RS21735	COG1162	GTPase activity
D1115_RS21740	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
D1115_RS21755	COG0531	amino acid
D1115_RS21760	COG1982	Orn Lys Arg decarboxylase major
D1115_RS21780	COG0366	Alpha amylase catalytic
D1115_RS21795	COG4580	involved in the transport of maltose and maltodextrins
D1115_RS21805	COG3706	GGDEF domain
D1115_RS21825	COG4771	TonB-dependent receptor
D1115_RS21830	COG0583	DNA-binding transcription factor activity
D1115_RS21835	COG4607	ABC-type enterochelin transport system periplasmic component
D1115_RS21840	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D1115_RS21845	COG4605	iron ion homeostasis
D1115_RS21850	COG4604	ABC transporter, ATP-binding protein
D1115_RS21885	COG0583	DNA-binding transcription factor activity
D1115_RS21890	COG0583	DNA-binding transcription factor activity
D1115_RS21895	COG0657	acetylesterase activity
D1115_RS21905	COG0826	peptidase U32
D1115_RS21920	COG1136	(ABC) transporter
D1115_RS21925	COG0577	efflux transmembrane transporter activity
D1115_RS21955	COG3634	alkyl hydroperoxide reductase activity
D1115_RS21960	COG1278	Cold shock
D1115_RS21965	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D1115_RS21970	COG1522	sequence-specific DNA binding
D1115_RS21975	COG0006	proline dipeptidase activity
D1115_RS22005	COG0596	Alpha beta hydrolase
D1115_RS22010	COG0596	Alpha beta hydrolase
D1115_RS22015	COG0513	Belongs to the DEAD box helicase family
D1115_RS22030	COG0583	DNA-binding transcription factor activity
D1115_RS22035	COG1312	Catalyzes the dehydration of D-mannonate
D1115_RS22040	COG0246	Mannitol dehydrogenase
D1115_RS22045	COG1904	glucuronate isomerase
D1115_RS22050	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D1115_RS22055	COG0800	Aldolase
D1115_RS22075	COG3250	beta-galactosidase activity
D1115_RS22085	COG2186	Transcriptional regulator
D1115_RS22140	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D1115_RS22220	COG1444	tRNA N-acetyltransferase activity
D1115_RS22235	COG1192	Involved in chromosome partitioning
D1115_RS22245	COG1028	Short-chain dehydrogenase reductase Sdr
D1115_RS22250	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D1115_RS22255	COG4569	acetaldehyde dehydrogenase (acetylating) activity
D1115_RS22265	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D1115_RS22305	COG2267	carboxylic ester hydrolase activity
D1115_RS22370	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
D1115_RS22380	COG2111	Na H antiporter
D1115_RS22380	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D1115_RS22410	COG1320	monovalent cation:proton antiporter activity
D1115_RS22440	COG2188	Transcriptional regulator
D1115_RS22475	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
D1115_RS22480	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
D1115_RS22490	COG1024	Enoyl-CoA hydratase
D1115_RS22495	COG1960	acyl-CoA dehydrogenase activity
D1115_RS22500	COG1960	acyl-CoA dehydrogenase activity
D1115_RS22505	COG0183	Belongs to the thiolase family
D1115_RS22510	COG1028	Short-chain dehydrogenase reductase Sdr
D1115_RS22520	COG2161	toxin-antitoxin pair type II binding
D1115_RS22525	COG4115	mRNA cleavage
D1115_RS22530	COG0653	protein targeting
D1115_RS22570	COG1960	acyl-CoA dehydrogenase activity
D1115_RS22585	COG2086	electron transfer activity
D1115_RS22605	COG1028	Short-chain dehydrogenase reductase Sdr
D1115_RS22630	COG1960	acyl-CoA dehydrogenase activity
D1115_RS22635	COG1960	acyl-CoA dehydrogenase activity
D1115_RS22650	COG3273	potassium ion transport
D1115_RS22650	COG0471	metal ion transport
D1115_RS22665	COG3848	Pyruvate phosphate dikinase
D1115_RS22665	COG0574	Belongs to the PEP-utilizing enzyme family
D1115_RS22670	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
D1115_RS22685	COG2176	DNA-directed DNA polymerase activity
D1115_RS22700	COG0438	transferase activity, transferring glycosyl groups
D1115_RS22705	COG0438	transferase activity, transferring glycosyl groups
D1115_RS22710	COG0297	glycogen (starch) synthase activity
D1115_RS22715	COG0367	asparagine synthase
D1115_RS22790	COG2076	Multidrug Resistance protein
D1115_RS22795	COG0546	phosphoglycolate phosphatase activity
D1115_RS22795	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
D1115_RS22825	COG0438	transferase activity, transferring glycosyl groups
D1115_RS22840	COG4974	Belongs to the 'phage' integrase family
D1115_RS22850	COG2204	response regulator
D1115_RS22880	COG1215	transferase activity, transferring glycosyl groups
D1115_RS22915	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D1115_RS22940	COG2963	transposase activity
D1115_RS22945	COG2801	Transposase and inactivated derivatives
D1115_RS22950	COG2801	Transposase and inactivated derivatives
D1115_RS22960	COG3706	GGDEF domain
D1115_RS22970	COG1024	Enoyl-CoA hydratase
D1115_RS22975	COG0183	Belongs to the thiolase family
D1115_RS23005	COG1028	Short-chain dehydrogenase reductase Sdr
D1115_RS23010	COG1902	pentaerythritol trinitrate reductase activity
D1115_RS23015	COG1028	Short-chain dehydrogenase reductase Sdr
D1115_RS23025	COG1053	succinate dehydrogenase
D1115_RS23040	COG2814	Major facilitator Superfamily