locus-tag	class	description
GPY28_RS00010	COG2337	Toxic component of a toxin-antitoxin (TA) module
GPY28_RS00055	COG0776	regulation of translation
GPY28_RS00085	COG0629	single-stranded DNA binding
GPY28_RS00145	COG1192	Involved in chromosome partitioning
GPY28_RS00150	COG1475	DNA binding
GPY28_RS00265	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GPY28_RS00270	COG0732	type I restriction modification DNA specificity domain
GPY28_RS00275	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GPY28_RS00365	COG2026	Addiction module toxin, RelE StbE family
GPY28_RS00435	COG3459	Glycosyltransferase 36 associated
GPY28_RS00455	COG0330	HflC and HflK could
GPY28_RS00475	COG1278	Cold shock
GPY28_RS00495	COG1278	Cold shock
GPY28_RS00515	COG1609	Transcriptional regulator
GPY28_RS00525	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPY28_RS00530	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GPY28_RS00535	COG1085	galactose-1-phosphate uridylyltransferase
GPY28_RS00550	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPY28_RS00575	COG4680	protein conserved in bacteria
GPY28_RS00580	COG5499	transcription regulator containing HTH domain
GPY28_RS00690	COG2161	toxin-antitoxin pair type II binding
GPY28_RS00695	COG4115	mRNA cleavage
GPY28_RS00725	COG3706	GGDEF domain
GPY28_RS00725	COG0745	RESPONSE REGULATOR receiver
GPY28_RS00780	COG4115	mRNA cleavage
GPY28_RS00795	COG1278	Cold shock
GPY28_RS00845	COG0641	radical SAM
GPY28_RS00850	COG0714	Associated with various cellular activities
GPY28_RS00880	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPY28_RS00885	COG0583	DNA-binding transcription factor activity
GPY28_RS00890	COG1597	lipid kinase activity
GPY28_RS00895	COG3111	PFAM Bacterial OB fold (BOF) protein
GPY28_RS00920	COG3069	C4-dicarboxylate transmembrane transporter activity
GPY28_RS00930	COG1214	PFAM Peptidase M22, glycoprotease
GPY28_RS00930	COG0456	acetyltransferase
GPY28_RS00950	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GPY28_RS00955	COG0784	Response regulator, receiver
GPY28_RS00955	COG2205	protein histidine kinase activity
GPY28_RS00960	COG5001	Diguanylate cyclase
GPY28_RS00960	COG3300	MHYT domain
GPY28_RS00965	COG2197	response regulator
GPY28_RS00970	COG3706	GGDEF domain
GPY28_RS00980	COG2197	response regulator
GPY28_RS00990	COG0784	Response regulator, receiver
GPY28_RS00990	COG0835	chemotaxis
GPY28_RS01005	COG2962	Rard protein
GPY28_RS01025	COG2076	Multidrug Resistance protein
GPY28_RS01060	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GPY28_RS01060	COG0069	glutamate synthase activity
GPY28_RS01065	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GPY28_RS01080	COG2755	lipolytic protein G-D-S-L family
GPY28_RS01080	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GPY28_RS01090	COG1902	pentaerythritol trinitrate reductase activity
GPY28_RS01095	COG0346	lactoylglutathione lyase activity
GPY28_RS01115	COG2239	Acts as a magnesium transporter
GPY28_RS01150	COG0242	peptide deformylase activity
GPY28_RS01190	COG2176	DNA-directed DNA polymerase activity
GPY28_RS01220	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GPY28_RS01225	COG0697	spore germination
GPY28_RS01230	COG0583	DNA-binding transcription factor activity
GPY28_RS01235	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPY28_RS01245	COG0346	lactoylglutathione lyase activity
GPY28_RS01255	COG0509	glycine decarboxylation via glycine cleavage system
GPY28_RS01260	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GPY28_RS01270	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GPY28_RS01300	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
GPY28_RS01300	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY28_RS01300	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY28_RS01305	COG1105	Belongs to the carbohydrate kinase PfkB family
GPY28_RS01310	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY28_RS01310	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY28_RS01315	COG1609	Transcriptional regulator
GPY28_RS01330	COG2203	Gaf domain
GPY28_RS01330	COG2199	diguanylate cyclase activity
GPY28_RS01330	COG2200	EAL domain
GPY28_RS01335	COG0765	amino acid transport
GPY28_RS01340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY28_RS01345	COG0765	amino acid transport
GPY28_RS01350	COG1126	abc transporter atp-binding protein
GPY28_RS01360	COG1979	alcohol dehydrogenase
GPY28_RS01365	COG2207	Transcriptional regulator
GPY28_RS01380	COG1943	Transposase
GPY28_RS01385	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GPY28_RS01390	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GPY28_RS01395	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY28_RS01410	COG0546	phosphoglycolate phosphatase activity
GPY28_RS01415	COG0840	transmembrane signaling receptor activity
GPY28_RS01425	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
GPY28_RS01430	COG0513	Belongs to the DEAD box helicase family
GPY28_RS01450	COG3038	cytochrome b561
GPY28_RS01455	COG2353	YceI-like domain
GPY28_RS01460	COG2116	formate transmembrane transporter activity
GPY28_RS01465	COG0583	DNA-binding transcription factor activity
GPY28_RS01475	COG3593	DNA synthesis involved in DNA repair
GPY28_RS01480	COG0737	Belongs to the 5'-nucleotidase family
GPY28_RS01485	COG0861	Integral membrane protein TerC family
GPY28_RS01505	COG2267	carboxylic ester hydrolase activity
GPY28_RS01510	COG2067	long-chain fatty acid transport protein
GPY28_RS01525	COG2050	protein possibly involved in aromatic compounds catabolism
GPY28_RS01535	COG4533	DNA binding
GPY28_RS01570	COG3300	MHYT domain
GPY28_RS01570	COG5001	Diguanylate cyclase
GPY28_RS01575	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GPY28_RS01585	COG4181	ATPase activity
GPY28_RS01590	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GPY28_RS01600	COG1984	allophanate hydrolase subunit 2
GPY28_RS01605	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GPY28_RS01610	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GPY28_RS01615	COG3447	MASE1 domain protein
GPY28_RS01615	COG5002	protein histidine kinase activity
GPY28_RS01615	COG5001	Diguanylate cyclase
GPY28_RS01635	COG0583	DNA-binding transcription factor activity
GPY28_RS01640	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY28_RS01640	COG1042	CoA-binding domain protein
GPY28_RS01640	COG0045	succinate-CoA ligase (ADP-forming) activity
GPY28_RS01650	COG1181	Belongs to the D-alanine--D-alanine ligase family
GPY28_RS01660	COG0023	Translation Initiation Factor
GPY28_RS01770	COG0583	DNA-binding transcription factor activity
GPY28_RS01785	COG3140	Belongs to the UPF0181 family
GPY28_RS01810	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GPY28_RS01815	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GPY28_RS01830	COG3706	GGDEF domain
GPY28_RS01830	COG0745	RESPONSE REGULATOR receiver
GPY28_RS01835	COG2203	Gaf domain
GPY28_RS01835	COG5001	Diguanylate cyclase
GPY28_RS01835	COG4251	negative regulation of phosphorylation
GPY28_RS01835	COG3706	GGDEF domain
GPY28_RS01845	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GPY28_RS01850	COG4149	molybdate abc transporter
GPY28_RS01855	COG0725	ABC transporter, periplasmic molybdate-binding protein
GPY28_RS01865	COG3111	PFAM Bacterial OB fold (BOF) protein
GPY28_RS01875	COG4067	protein conserved in archaea
GPY28_RS01875	COG0189	ligase activity
GPY28_RS01885	COG2207	Transcriptional regulator
GPY28_RS01890	COG0534	Mate efflux family protein
GPY28_RS01895	COG0602	queuosine metabolic process
GPY28_RS01900	COG1328	CTP reductase activity
GPY28_RS01930	COG1794	racemase activity, acting on amino acids and derivatives
GPY28_RS01935	COG0384	phenazine biosynthesis protein PhzF
GPY28_RS01950	COG0243	molybdopterin cofactor binding
GPY28_RS01960	COG0583	DNA-binding transcription factor activity
GPY28_RS01965	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GPY28_RS01975	COG2197	response regulator
GPY28_RS01980	COG3851	Histidine kinase
GPY28_RS01985	COG2271	Major facilitator Superfamily
GPY28_RS02010	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GPY28_RS02015	COG3118	belongs to the thioredoxin family
GPY28_RS02020	COG2814	Major facilitator Superfamily
GPY28_RS02050	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GPY28_RS02070	COG2116	formate transmembrane transporter activity
GPY28_RS02075	COG2146	nitrite reductase [NAD(P)H] activity
GPY28_RS02080	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GPY28_RS02085	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY28_RS02105	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GPY28_RS02155	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPY28_RS02170	COG0277	FAD linked oxidase domain protein
GPY28_RS02175	COG0583	DNA-binding transcription factor activity
GPY28_RS02190	COG2425	protein containing a von Willebrand factor type A (vWA) domain
GPY28_RS02205	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
GPY28_RS02215	COG1288	antiporter activity
GPY28_RS02225	COG3040	lipid binding
GPY28_RS02235	COG0419	ATPase involved in DNA repair
GPY28_RS02240	COG0420	3'-5' exonuclease activity
GPY28_RS02255	COG3501	Rhs element vgr protein
GPY28_RS02310	COG0631	protein serine/threonine phosphatase activity
GPY28_RS02345	COG0515	serine threonine protein kinase
GPY28_RS02345	COG2815	serine threonine protein kinase
GPY28_RS02395	COG2146	nitrite reductase [NAD(P)H] activity
GPY28_RS02395	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GPY28_RS02400	COG1116	anion transmembrane transporter activity
GPY28_RS02405	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GPY28_RS02410	COG1116	anion transmembrane transporter activity
GPY28_RS02410	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GPY28_RS02420	COG3707	response regulator
GPY28_RS02440	COG0243	molybdopterin cofactor binding
GPY28_RS02450	COG0814	amino acid
GPY28_RS02460	COG3706	GGDEF domain
GPY28_RS02525	COG2847	Copper chaperone PCu(A)C
GPY28_RS02530	COG1028	Short-chain dehydrogenase reductase Sdr
GPY28_RS02535	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GPY28_RS02545	COG0800	Aldolase
GPY28_RS02550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY28_RS02555	COG1917	Cupin 2, conserved barrel domain protein
GPY28_RS02600	COG2186	Transcriptional regulator
GPY28_RS02605	COG2186	Transcriptional regulator
GPY28_RS02610	COG0517	IMP dehydrogenase activity
GPY28_RS02615	COG2176	DNA-directed DNA polymerase activity
GPY28_RS02620	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPY28_RS02690	COG4160	amino acid transport
GPY28_RS02695	COG4215	(ABC) transporter
GPY28_RS02700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY28_RS02705	COG1126	abc transporter atp-binding protein
GPY28_RS02735	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPY28_RS02745	COG1012	belongs to the aldehyde dehydrogenase family
GPY28_RS02760	COG1902	pentaerythritol trinitrate reductase activity
GPY28_RS02760	COG0446	pyridine nucleotide-disulphide oxidoreductase
GPY28_RS02765	COG0109	protoheme IX farnesyltransferase activity
GPY28_RS02770	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GPY28_RS02775	COG1845	cytochrome c oxidase, subunit III
GPY28_RS02780	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GPY28_RS02785	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GPY28_RS02790	COG1028	Short-chain dehydrogenase reductase Sdr
GPY28_RS02800	COG1024	Enoyl-CoA hydratase
GPY28_RS02805	COG1024	Enoyl-CoA hydratase
GPY28_RS02820	COG0183	Belongs to the thiolase family
GPY28_RS02830	COG1960	acyl-CoA dehydrogenase activity
GPY28_RS02835	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GPY28_RS02840	COG1024	Enoyl-CoA hydratase
GPY28_RS02865	COG2095	MarC family integral membrane protein
GPY28_RS02870	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GPY28_RS02880	COG0523	cobalamin synthesis protein
GPY28_RS02885	COG0739	heme binding
GPY28_RS02895	COG0523	cobalamin synthesis protein
GPY28_RS02905	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GPY28_RS02910	COG0735	belongs to the Fur family
GPY28_RS02925	COG0730	response to heat
GPY28_RS02940	COG1073	alpha beta
GPY28_RS02945	COG1073	alpha beta
GPY28_RS02955	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GPY28_RS02970	COG0513	Belongs to the DEAD box helicase family
GPY28_RS02975	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
GPY28_RS02990	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GPY28_RS03010	COG1119	ATPase activity
GPY28_RS03015	COG2200	EAL domain
GPY28_RS03035	COG0513	Belongs to the DEAD box helicase family
GPY28_RS03040	COG0523	cobalamin synthesis protein
GPY28_RS03050	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
GPY28_RS03060	COG1278	Cold shock
GPY28_RS03070	COG0133	tryptophan synthase activity
GPY28_RS03080	COG4628	conserved protein (DUF2132)
GPY28_RS03085	COG0513	Belongs to the DEAD box helicase family
GPY28_RS03095	COG0730	response to heat
GPY28_RS03120	COG2186	Transcriptional regulator
GPY28_RS03135	COG3530	Putative quorum-sensing-regulated virulence factor
GPY28_RS03160	COG3186	Phenylalanine-4-hydroxylase
GPY28_RS03165	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPY28_RS03170	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPY28_RS03190	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
GPY28_RS03195	COG1454	alcohol dehydrogenase
GPY28_RS03200	COG2133	pyrroloquinoline quinone binding
GPY28_RS03210	COG0783	Belongs to the Dps family
GPY28_RS03215	COG0840	transmembrane signaling receptor activity
GPY28_RS03240	COG2205	protein histidine kinase activity
GPY28_RS03240	COG0784	Response regulator, receiver
GPY28_RS03245	COG1538	Outer membrane efflux protein
GPY28_RS03255	COG1132	(ABC) transporter
GPY28_RS03270	COG2199	diguanylate cyclase activity
GPY28_RS03275	COG3036	rescue of stalled ribosome
GPY28_RS03280	COG1278	Cold shock
GPY28_RS03310	COG0545	Peptidyl-prolyl cis-trans isomerase
GPY28_RS03315	COG0109	protoheme IX farnesyltransferase activity
GPY28_RS03320	COG1612	heme a metabolic process
GPY28_RS03340	COG1845	cytochrome c oxidase, subunit III
GPY28_RS03345	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
GPY28_RS03355	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GPY28_RS03360	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPY28_RS03370	COG1280	lysine exporter protein (LysE YggA)
GPY28_RS03390	COG0179	Fumarylacetoacetate (FAA) hydrolase
GPY28_RS03405	COG0697	spore germination
GPY28_RS03425	COG2814	Major facilitator Superfamily
GPY28_RS03430	COG0583	DNA-binding transcription factor activity
GPY28_RS03435	COG5001	Diguanylate cyclase
GPY28_RS03440	COG0739	heme binding
GPY28_RS03480	COG0814	amino acid
GPY28_RS03505	COG4989	oxidoreductase activity
GPY28_RS03530	COG1733	regulation of RNA biosynthetic process
GPY28_RS03545	COG0798	PFAM Bile acid sodium symporter
GPY28_RS03555	COG1881	PFAM PEBP family protein
GPY28_RS03565	COG0251	oxidation-reduction process
GPY28_RS03570	COG2706	6-phosphogluconolactonase activity
GPY28_RS03580	COG0800	Aldolase
GPY28_RS03585	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY28_RS03590	COG4145	pantothenate transmembrane transporter activity
GPY28_RS03600	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
GPY28_RS03620	COG1131	(ABC) transporter
GPY28_RS03625	COG0842	Transport permease protein
GPY28_RS03635	COG3383	formate dehydrogenase (NAD+) activity
GPY28_RS03655	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY28_RS03680	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY28_RS03690	COG2067	long-chain fatty acid transport protein
GPY28_RS03700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY28_RS03710	COG1505	serine-type exopeptidase activity
GPY28_RS03715	COG0488	(ABC) transporter
GPY28_RS03720	COG0589	response to stress
GPY28_RS03725	COG2249	NAD(P)H dehydrogenase (quinone) activity
GPY28_RS03745	COG0366	Alpha amylase catalytic
GPY28_RS03750	COG0789	Transcriptional regulator
GPY28_RS03755	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GPY28_RS03765	COG4934	collagen metabolic process
GPY28_RS03775	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GPY28_RS03780	COG0583	DNA-binding transcription factor activity
GPY28_RS03800	COG2610	gluconate transmembrane transporter activity
GPY28_RS03805	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GPY28_RS03810	COG3622	Belongs to the hyi family
GPY28_RS03815	COG0235	Class ii aldolase
GPY28_RS03820	COG3395	kinase activity
GPY28_RS03825	COG2084	Dehydrogenase
GPY28_RS03830	COG1349	DNA-binding transcription factor activity
GPY28_RS03840	COG0747	negative chemotaxis
GPY28_RS03845	COG4608	Belongs to the ABC transporter superfamily
GPY28_RS03850	COG0444	Belongs to the ABC transporter superfamily
GPY28_RS03855	COG0534	Mate efflux family protein
GPY28_RS03860	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPY28_RS03865	COG0784	Response regulator, receiver
GPY28_RS03865	COG0835	chemotaxis
GPY28_RS03875	COG0748	coenzyme F420 binding
GPY28_RS03880	COG3721	Heme iron utilization protein
GPY28_RS03890	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GPY28_RS03895	COG0811	peptide transport
GPY28_RS03900	COG0848	biopolymer transport protein
GPY28_RS03910	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY28_RS03915	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GPY28_RS03930	COG1943	Transposase
GPY28_RS03960	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GPY28_RS03970	COG0633	Ferredoxin
GPY28_RS03970	COG3217	Mosc domain protein beta barrel domain protein
GPY28_RS03970	COG3217	Mosc domain protein beta barrel domain protein
GPY28_RS03970	COG0633	Ferredoxin
GPY28_RS03975	COG0401	homolog of Blt101
GPY28_RS03985	COG0418	dihydroorotase activity
GPY28_RS03990	COG2354	Protein conserved in bacteria
GPY28_RS04000	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY28_RS04005	COG4605	iron ion homeostasis
GPY28_RS04010	COG4607	ABC-type enterochelin transport system periplasmic component
GPY28_RS04015	COG4774	siderophore transport
GPY28_RS04020	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GPY28_RS04050	COG3833	ABC-type maltose transport systems, permease component
GPY28_RS04055	COG1175	transmembrane transport
GPY28_RS04065	COG3842	ATPase activity
GPY28_RS04070	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GPY28_RS04085	COG3206	protein involved in exopolysaccharide biosynthesis
GPY28_RS04085	COG0489	protein tyrosine kinase activity
GPY28_RS04130	COG1309	transcriptional regulator
GPY28_RS04135	COG2130	NADP-dependent
GPY28_RS04145	COG0753	catalase activity
GPY28_RS04150	COG2084	Dehydrogenase
GPY28_RS04180	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY28_RS04185	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
GPY28_RS04195	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPY28_RS04200	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GPY28_RS04220	COG0583	DNA-binding transcription factor activity
GPY28_RS04225	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY28_RS04230	COG0569	domain protein
GPY28_RS04235	COG0745	RESPONSE REGULATOR receiver
GPY28_RS04240	COG5002	protein histidine kinase activity
GPY28_RS04245	COG1132	(ABC) transporter
GPY28_RS04250	COG4774	siderophore transport
GPY28_RS04255	COG1120	ATPase activity
GPY28_RS04260	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GPY28_RS04295	COG2197	response regulator
GPY28_RS04310	COG0714	Associated with various cellular activities
GPY28_RS04330	COG2304	oxidoreductase activity
GPY28_RS04345	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GPY28_RS04350	COG0581	inorganic phosphate transmembrane transporter activity
GPY28_RS04355	COG0573	inorganic phosphate transmembrane transporter activity
GPY28_RS04360	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GPY28_RS04385	COG4771	TonB-dependent receptor
GPY28_RS04390	COG1770	oligopeptidase
GPY28_RS04395	COG0513	Belongs to the DEAD box helicase family
GPY28_RS04405	COG1388	LysM domain
GPY28_RS04405	COG1376	ErfK ybiS ycfS ynhG family protein
GPY28_RS04410	COG0415	Belongs to the DNA photolyase family
GPY28_RS04415	COG0789	Transcriptional regulator
GPY28_RS04420	COG3272	Protein of unknown function (DUF1722)
GPY28_RS04430	COG0813	purine-nucleoside phosphorylase activity
GPY28_RS04445	COG3706	GGDEF domain
GPY28_RS04455	COG1566	PFAM secretion protein HlyD family protein
GPY28_RS04460	COG4720	Psort location CytoplasmicMembrane, score
GPY28_RS04465	COG1122	ATPase activity
GPY28_RS04485	COG0348	domain, Protein
GPY28_RS04490	COG0437	4 iron, 4 sulfur cluster binding
GPY28_RS04495	COG1247	-acetyltransferase
GPY28_RS04515	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPY28_RS04525	COG1067	ATP-dependent peptidase activity
GPY28_RS04535	COG4172	Belongs to the ABC transporter superfamily
GPY28_RS04540	COG1505	serine-type exopeptidase activity
GPY28_RS04545	COG0583	DNA-binding transcription factor activity
GPY28_RS04550	COG1620	l-lactate permease
GPY28_RS04555	COG1304	FMN binding
GPY28_RS04565	COG0668	transmembrane transport
GPY28_RS04600	COG1063	alcohol dehydrogenase
GPY28_RS04605	COG0156	8-amino-7-oxononanoate synthase activity
GPY28_RS04610	COG5001	Diguanylate cyclase
GPY28_RS04610	COG3300	MHYT domain
GPY28_RS04635	COG0745	RESPONSE REGULATOR receiver
GPY28_RS04660	COG0346	lactoylglutathione lyase activity
GPY28_RS04720	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GPY28_RS04735	COG2204	response regulator
GPY28_RS04760	COG1987	bacterial-type flagellum assembly
GPY28_RS04770	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GPY28_RS04785	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY28_RS04795	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GPY28_RS04800	COG1516	flagellar protein fliS
GPY28_RS04815	COG1580	Controls the rotational direction of flagella during chemotaxis
GPY28_RS04820	COG1191	sigma factor activity
GPY28_RS04825	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GPY28_RS04830	COG1360	Flagellar Motor Protein
GPY28_RS04870	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GPY28_RS04875	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GPY28_RS04890	COG2205	protein histidine kinase activity
GPY28_RS04895	COG0745	RESPONSE REGULATOR receiver
GPY28_RS04905	COG0454	-acetyltransferase
GPY28_RS04915	COG2814	Major facilitator Superfamily
GPY28_RS04960	COG0628	permease
GPY28_RS04965	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GPY28_RS04985	COG4628	conserved protein (DUF2132)
GPY28_RS04990	COG0583	DNA-binding transcription factor activity
GPY28_RS05015	COG1686	Belongs to the peptidase S11 family
GPY28_RS05035	COG0415	Belongs to the DNA photolyase family
GPY28_RS05040	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
GPY28_RS05045	COG3397	chitin binding
GPY28_RS05050	COG4667	esterase of the alpha-beta hydrolase superfamily
GPY28_RS05055	COG2095	MarC family integral membrane protein
GPY28_RS05075	COG3206	protein involved in exopolysaccharide biosynthesis
GPY28_RS05075	COG0489	protein tyrosine kinase activity
GPY28_RS05100	COG1301	dicarboxylic acid transport
GPY28_RS05115	COG3339	Conserved Protein
GPY28_RS05125	COG0700	Nucleoside recognition
GPY28_RS05130	COG3366	ferrous iron transmembrane transporter activity
GPY28_RS05145	COG0366	Alpha amylase catalytic
GPY28_RS05150	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GPY28_RS05155	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GPY28_RS05160	COG1640	4-alpha-glucanotransferase
GPY28_RS05165	COG0058	SHG alpha-glucan phosphorylase activity
GPY28_RS05170	COG2909	trisaccharide binding
GPY28_RS05185	COG1999	signal sequence binding
GPY28_RS05190	COG1263	PTS System
GPY28_RS05190	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY28_RS05195	COG1162	GTPase activity
GPY28_RS05200	COG1943	Transposase
GPY28_RS05205	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GPY28_RS05210	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
GPY28_RS05220	COG0531	amino acid
GPY28_RS05225	COG1982	Orn Lys Arg decarboxylase major
GPY28_RS05245	COG2356	endonuclease I
GPY28_RS05265	COG4580	involved in the transport of maltose and maltodextrins
GPY28_RS05275	COG1760	l-serine dehydratase
GPY28_RS05325	COG1609	Transcriptional regulator
GPY28_RS05330	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GPY28_RS05355	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPY28_RS05360	COG1609	Transcriptional regulator
GPY28_RS05365	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GPY28_RS05370	COG2814	Major facilitator Superfamily
GPY28_RS05385	COG0739	heme binding
GPY28_RS05395	COG0612	Peptidase, M16
GPY28_RS05400	COG0840	transmembrane signaling receptor activity
GPY28_RS05405	COG1120	ATPase activity
GPY28_RS05410	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY28_RS05415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY28_RS05420	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GPY28_RS05425	COG4772	TonB-dependent receptor
GPY28_RS05450	COG4264	IucA IucC family
GPY28_RS05455	COG0019	diaminopimelate decarboxylase activity
GPY28_RS05475	COG1136	(ABC) transporter
GPY28_RS05515	COG1764	response to oxidative stress
GPY28_RS05520	COG1846	Transcriptional regulator
GPY28_RS05525	COG0450	alkyl hydroperoxide reductase
GPY28_RS05530	COG3634	alkyl hydroperoxide reductase activity
GPY28_RS05590	COG2258	MOSC domain
GPY28_RS05595	COG0513	Belongs to the DEAD box helicase family
GPY28_RS05605	COG1132	(ABC) transporter
GPY28_RS05645	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPY28_RS05670	COG0259	pyridoxamine-phosphate oxidase activity
GPY28_RS05715	COG4166	transmembrane transport
GPY28_RS05735	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GPY28_RS05740	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY28_RS05740	COG1263	PTS System
GPY28_RS05745	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPY28_RS05750	COG3340	Belongs to the peptidase S51 family
GPY28_RS05770	COG1444	tRNA N-acetyltransferase activity
GPY28_RS05795	COG4608	Belongs to the ABC transporter superfamily
GPY28_RS05800	COG0444	Belongs to the ABC transporter superfamily
GPY28_RS05810	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GPY28_RS05810	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
GPY28_RS05835	COG0772	Belongs to the SEDS family
GPY28_RS05865	COG3275	phosphorelay sensor kinase activity
GPY28_RS05870	COG3279	Response regulator of the LytR AlgR family
GPY28_RS05880	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GPY28_RS05900	COG0786	glutamate:sodium symporter activity
GPY28_RS05910	COG1131	(ABC) transporter
GPY28_RS05915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY28_RS05920	COG0786	glutamate:sodium symporter activity
GPY28_RS05930	COG0363	glucosamine-6-phosphate deaminase activity
GPY28_RS05950	COG1741	Belongs to the pirin family
GPY28_RS05955	COG2259	Doxx family
GPY28_RS05965	COG2169	Transcriptional regulator
GPY28_RS05965	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GPY28_RS05970	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GPY28_RS05980	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GPY28_RS06005	COG0596	Alpha beta hydrolase
GPY28_RS06020	COG3123	guanosine phosphorylase activity
GPY28_RS06030	COG5001	Diguanylate cyclase
GPY28_RS06035	COG0534	Mate efflux family protein
GPY28_RS06040	COG0564	pseudouridine synthase activity
GPY28_RS06055	COG0583	DNA-binding transcription factor activity
GPY28_RS06060	COG0561	phosphatase activity
GPY28_RS06070	COG2199	diguanylate cyclase activity
GPY28_RS06085	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
GPY28_RS06090	COG2162	N-hydroxyarylamine O-acetyltransferase activity
GPY28_RS06095	COG0583	DNA-binding transcription factor activity
GPY28_RS06100	COG2375	cellular response to nickel ion
GPY28_RS06130	COG1357	PFAM Pentapeptide repeats (8 copies)
GPY28_RS06135	COG3047	cAMP biosynthetic process
GPY28_RS06195	COG3835	regulator
GPY28_RS06200	COG2610	gluconate transmembrane transporter activity
GPY28_RS06205	COG1929	Belongs to the glycerate kinase type-1 family
GPY28_RS06210	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY28_RS06230	COG0456	acetyltransferase
GPY28_RS06245	COG1028	Short-chain dehydrogenase reductase Sdr
GPY28_RS06250	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY28_RS06255	COG3005	denitrification pathway
GPY28_RS06260	COG0243	molybdopterin cofactor binding
GPY28_RS06280	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GPY28_RS06285	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GPY28_RS06290	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GPY28_RS06295	COG1116	anion transmembrane transporter activity
GPY28_RS06300	COG0351	phosphomethylpyrimidine kinase
GPY28_RS06305	COG0312	modulator of DNA gyrase
GPY28_RS06310	COG0312	modulator of DNA gyrase
GPY28_RS06315	COG1901	pseudouridine methyltransferase
GPY28_RS06375	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GPY28_RS06385	COG0584	glycerophosphoryl diester phosphodiesterase
GPY28_RS06390	COG0745	RESPONSE REGULATOR receiver
GPY28_RS06410	COG0811	peptide transport
GPY28_RS06415	COG0811	peptide transport
GPY28_RS06420	COG0848	biopolymer transport protein
GPY28_RS06465	COG0803	Belongs to the bacterial solute-binding protein 9 family
GPY28_RS06470	COG1121	(ABC) transporter
GPY28_RS06475	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GPY28_RS06490	COG1770	oligopeptidase
GPY28_RS06495	COG2814	Major facilitator Superfamily
GPY28_RS06500	COG0010	Belongs to the arginase family
GPY28_RS06505	COG1166	arginine decarboxylase activity
GPY28_RS06515	COG4067	protein conserved in archaea
GPY28_RS06515	COG0189	ligase activity
GPY28_RS06520	COG0189	ligase activity
GPY28_RS06540	COG0583	DNA-binding transcription factor activity
GPY28_RS06570	COG3706	GGDEF domain
GPY28_RS06595	COG0579	oxidoreductase
GPY28_RS06615	COG1294	oxidase, subunit
GPY28_RS06620	COG1271	oxidase subunit
GPY28_RS06630	COG3033	Beta-eliminating lyase
GPY28_RS06645	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPY28_RS06660	COG3706	GGDEF domain
GPY28_RS06675	COG3706	GGDEF domain
GPY28_RS06680	COG0415	Belongs to the DNA photolyase family
GPY28_RS06685	COG3046	protein related to deoxyribodipyrimidine photolyase
GPY28_RS06700	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY28_RS06700	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY28_RS06705	COG1765	OsmC-like protein
GPY28_RS06710	COG0110	maltose O-acetyltransferase activity
GPY28_RS06735	COG1011	Hydrolase
GPY28_RS06750	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
GPY28_RS06760	COG2067	long-chain fatty acid transport protein
GPY28_RS06765	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY28_RS06770	COG0577	efflux transmembrane transporter activity
GPY28_RS06770	COG1136	(ABC) transporter
GPY28_RS06785	COG1309	transcriptional regulator
GPY28_RS06790	COG3240	lipase activity
GPY28_RS06820	COG1609	Transcriptional regulator
GPY28_RS06840	COG1840	ABC-type Fe3 transport system, periplasmic component
GPY28_RS06845	COG3842	ATPase activity
GPY28_RS06870	COG2990	Protein conserved in bacteria
GPY28_RS06880	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPY28_RS06885	COG2866	Carboxypeptidase
GPY28_RS06895	COG0583	DNA-binding transcription factor activity
GPY28_RS06910	COG1760	l-serine dehydratase
GPY28_RS06930	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GPY28_RS06935	COG0741	lytic transglycosylase activity
GPY28_RS06935	COG1388	LysM domain
GPY28_RS06955	COG1815	bacterial-type flagellum-dependent cell motility
GPY28_RS06960	COG1558	bacterial-type flagellum-dependent cell motility
GPY28_RS06965	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GPY28_RS06970	COG1749	Flagellar hook protein flgE
GPY28_RS06975	COG4787	bacterial-type flagellum-dependent cell motility
GPY28_RS06980	COG4786	Flagellar basal body rod
GPY28_RS06985	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GPY28_RS06990	COG1706	bacterial-type flagellum-dependent cell motility
GPY28_RS07000	COG1256	bacterial-type flagellum assembly
GPY28_RS07000	COG4786	Flagellar basal body rod
GPY28_RS07025	COG1304	FMN binding
GPY28_RS07040	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY28_RS07050	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GPY28_RS07055	COG0459	protein refolding
GPY28_RS07065	COG1280	lysine exporter protein (LysE YggA)
GPY28_RS07085	COG1309	transcriptional regulator
GPY28_RS07095	COG4303	Ethanolamine ammonia lyase large subunit
GPY28_RS07100	COG4302	ethanolamine ammonia-lyase activity
GPY28_RS07105	COG0531	amino acid
GPY28_RS07110	COG2070	2-Nitropropane dioxygenase
GPY28_RS07115	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY28_RS07115	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY28_RS07120	COG1349	DNA-binding transcription factor activity
GPY28_RS07135	COG1335	isochorismatase
GPY28_RS07145	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GPY28_RS07170	COG0583	DNA-binding transcription factor activity
GPY28_RS07185	COG3713	MltA-interacting MipA family protein
GPY28_RS07190	COG3015	lipoprotein NlpE involved in copper resistance
GPY28_RS07195	COG4175	Glycine betaine
GPY28_RS07195	COG3448	diguanylate cyclase activity
GPY28_RS07200	COG4176	ABC-type proline glycine betaine transport system permease component
GPY28_RS07205	COG1342	Belongs to the UPF0251 family
GPY28_RS07230	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPY28_RS07240	COG4948	Mandelate Racemase Muconate Lactonizing
GPY28_RS07250	COG0583	DNA-binding transcription factor activity
GPY28_RS07285	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GPY28_RS07290	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GPY28_RS07320	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY28_RS07340	COG3842	ATPase activity
GPY28_RS07370	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPY28_RS07390	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY28_RS07395	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GPY28_RS07400	COG2197	response regulator
GPY28_RS07415	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GPY28_RS07420	COG0252	asparaginase activity
GPY28_RS07430	COG0583	DNA-binding transcription factor activity
GPY28_RS07445	COG3122	Protein conserved in bacteria
GPY28_RS07450	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GPY28_RS07455	COG1012	belongs to the aldehyde dehydrogenase family
GPY28_RS07460	COG1522	sequence-specific DNA binding
GPY28_RS07465	COG3608	succinylglutamate desuccinylase aspartoacylase
GPY28_RS07470	COG0006	proline dipeptidase activity
GPY28_RS07475	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY28_RS07485	COG1028	Short-chain dehydrogenase reductase Sdr
GPY28_RS07495	COG1063	alcohol dehydrogenase
GPY28_RS07500	COG1902	pentaerythritol trinitrate reductase activity
GPY28_RS07515	COG0583	DNA-binding transcription factor activity
GPY28_RS07525	COG0513	Belongs to the DEAD box helicase family
GPY28_RS07565	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY28_RS07570	COG2207	Transcriptional regulator
GPY28_RS07570	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GPY28_RS07575	COG0583	DNA-binding transcription factor activity
GPY28_RS07595	COG3746	phosphate-selective porin O and P
GPY28_RS07610	COG1028	Short-chain dehydrogenase reductase Sdr
GPY28_RS07635	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY28_RS07635	COG1263	PTS System
GPY28_RS07640	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY28_RS07645	COG1621	beta-fructofuranosidase activity
GPY28_RS07655	COG0625	glutathione transferase activity
GPY28_RS07660	COG1686	Belongs to the peptidase S11 family
GPY28_RS07670	COG0678	peroxiredoxin activity
GPY28_RS07670	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPY28_RS07675	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GPY28_RS07690	COG1278	Cold shock
GPY28_RS07695	COG1741	Belongs to the pirin family
GPY28_RS07700	COG4667	esterase of the alpha-beta hydrolase superfamily
GPY28_RS07720	COG2194	sulfuric ester hydrolase activity
GPY28_RS07725	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GPY28_RS07735	COG2205	protein histidine kinase activity
GPY28_RS07740	COG0745	RESPONSE REGULATOR receiver
GPY28_RS07755	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPY28_RS07775	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GPY28_RS07785	COG2814	Major facilitator Superfamily
GPY28_RS07800	COG1418	mRNA catabolic process
GPY28_RS07805	COG0402	S-adenosylhomocysteine deaminase activity
GPY28_RS07810	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GPY28_RS07815	COG2239	Acts as a magnesium transporter
GPY28_RS07820	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GPY28_RS07825	COG1566	PFAM secretion protein HlyD family protein
GPY28_RS07850	COG0745	RESPONSE REGULATOR receiver
GPY28_RS07855	COG2205	protein histidine kinase activity
GPY28_RS07870	COG0531	amino acid
GPY28_RS07885	COG0583	DNA-binding transcription factor activity
GPY28_RS07910	COG2205	protein histidine kinase activity
GPY28_RS07910	COG5002	protein histidine kinase activity
GPY28_RS07910	COG0784	Response regulator, receiver
GPY28_RS07930	COG3132	Protein of unknown function, DUF480
GPY28_RS07935	COG2827	Endonuclease containing a URI domain
GPY28_RS07940	COG1879	ABC-type sugar transport system periplasmic component
GPY28_RS07945	COG2205	protein histidine kinase activity
GPY28_RS07945	COG0784	Response regulator, receiver
GPY28_RS07950	COG1846	Transcriptional regulator
GPY28_RS08000	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY28_RS08005	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY28_RS08015	COG1280	lysine exporter protein (LysE YggA)
GPY28_RS08025	COG0183	Belongs to the thiolase family
GPY28_RS08035	COG3243	poly(R)-hydroxyalkanoic acid synthase
GPY28_RS08045	COG3005	denitrification pathway
GPY28_RS08055	COG0243	molybdopterin cofactor binding
GPY28_RS08065	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GPY28_RS08070	COG3850	Histidine kinase
GPY28_RS08075	COG2197	response regulator
GPY28_RS08090	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPY28_RS08110	COG0840	transmembrane signaling receptor activity
GPY28_RS08120	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY28_RS08130	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY28_RS08135	COG2814	Major facilitator Superfamily
GPY28_RS08145	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GPY28_RS08150	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GPY28_RS08165	COG2897	thiosulfate sulfurtransferase activity
GPY28_RS08200	COG0038	chloride channel
GPY28_RS08215	COG4989	oxidoreductase activity
GPY28_RS08230	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GPY28_RS08230	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GPY28_RS08255	COG3537	Alpha-1,2-mannosidase
GPY28_RS08265	COG3537	Alpha-1,2-mannosidase
GPY28_RS08270	COG3537	Alpha-1,2-mannosidase
GPY28_RS08275	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY28_RS08290	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY28_RS08290	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY28_RS08290	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY28_RS08295	COG2207	Transcriptional regulator
GPY28_RS08305	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY28_RS08310	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY28_RS08335	COG0739	heme binding
GPY28_RS08375	COG3501	Rhs element vgr protein
GPY28_RS08400	COG0515	serine threonine protein kinase
GPY28_RS08435	COG1522	sequence-specific DNA binding
GPY28_RS08500	COG1943	Transposase
GPY28_RS08505	COG2814	Major facilitator Superfamily
GPY28_RS08515	COG0583	DNA-binding transcription factor activity
GPY28_RS08520	COG4221	oxidoreductase activity
GPY28_RS08525	COG0589	response to stress
GPY28_RS08535	COG2111	Na H antiporter
GPY28_RS08535	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GPY28_RS08540	COG1006	Multisubunit Na H antiporter MnhC subunit
GPY28_RS08555	COG2212	antiporter activity
GPY28_RS08560	COG1320	monovalent cation:proton antiporter activity
GPY28_RS08565	COG2188	Transcriptional regulator
GPY28_RS08570	COG1486	melibiose metabolic process
GPY28_RS08575	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY28_RS08575	COG1263	PTS System
GPY28_RS08580	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPY28_RS08610	COG1022	Amp-dependent synthetase and ligase
GPY28_RS08640	COG0500	methyltransferase
GPY28_RS08655	COG3527	Alpha-acetolactate decarboxylase
GPY28_RS08665	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY28_RS08680	COG1294	oxidase, subunit
GPY28_RS08685	COG1271	oxidase subunit
GPY28_RS08690	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY28_RS08695	COG0110	maltose O-acetyltransferase activity
GPY28_RS08705	COG3264	Mechanosensitive ion channel
GPY28_RS08705	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GPY28_RS08730	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GPY28_RS08735	COG1960	acyl-CoA dehydrogenase activity
GPY28_RS08745	COG0183	Belongs to the thiolase family
GPY28_RS08755	COG1960	acyl-CoA dehydrogenase activity
GPY28_RS08760	COG1024	Enoyl-CoA hydratase
GPY28_RS08775	COG1028	Short-chain dehydrogenase reductase Sdr
GPY28_RS08780	COG3706	GGDEF domain
GPY28_RS08780	COG0745	RESPONSE REGULATOR receiver
GPY28_RS08785	COG1309	transcriptional regulator
GPY28_RS08790	COG1012	belongs to the aldehyde dehydrogenase family
GPY28_RS08805	COG4176	ABC-type proline glycine betaine transport system permease component
GPY28_RS08810	COG4175	Glycine betaine
GPY28_RS08810	COG0517	IMP dehydrogenase activity
GPY28_RS08825	COG0330	HflC and HflK could
GPY28_RS08840	COG0784	Response regulator, receiver
GPY28_RS08840	COG2205	protein histidine kinase activity
GPY28_RS08850	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GPY28_RS08905	COG5001	Diguanylate cyclase
GPY28_RS08910	COG1869	D-ribose catabolic process
GPY28_RS08915	COG1129	ABC transporter
GPY28_RS08920	COG1172	Belongs to the binding-protein-dependent transport system permease family
GPY28_RS08925	COG1879	ABC-type sugar transport system periplasmic component
GPY28_RS08930	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY28_RS08935	COG1609	Transcriptional regulator
GPY28_RS08950	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
GPY28_RS08955	COG1943	Transposase
GPY28_RS08965	COG4607	ABC-type enterochelin transport system periplasmic component
GPY28_RS08970	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY28_RS08975	COG4605	iron ion homeostasis
GPY28_RS08980	COG4604	ABC transporter, ATP-binding protein
GPY28_RS08985	COG0789	Transcriptional regulator
GPY28_RS08995	COG1629	transport
GPY28_RS08995	COG4771	TonB-dependent receptor
GPY28_RS09025	COG1289	transmembrane transporter activity
GPY28_RS09030	COG0210	DNA helicase
GPY28_RS09035	COG1803	Methylglyoxal synthase
GPY28_RS09040	COG1879	ABC-type sugar transport system periplasmic component
GPY28_RS09045	COG0784	Response regulator, receiver
GPY28_RS09045	COG2198	Histidine kinase
GPY28_RS09045	COG2205	protein histidine kinase activity
GPY28_RS09060	COG0745	RESPONSE REGULATOR receiver
GPY28_RS09065	COG3119	arylsulfatase activity
GPY28_RS09085	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GPY28_RS09095	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GPY28_RS09105	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GPY28_RS09110	COG0527	aspartate kinase activity
GPY28_RS09110	COG0460	homoserine dehydrogenase
GPY28_RS09115	COG0626	cystathionine gamma-synthase activity
GPY28_RS09125	COG0281	malic enzyme
GPY28_RS09135	COG2906	2 iron, 2 sulfur cluster binding
GPY28_RS09140	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GPY28_RS09145	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPY28_RS09165	COG2923	Belongs to the DsrF TusC family
GPY28_RS09170	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GPY28_RS09175	COG2964	Protein conserved in bacteria
GPY28_RS09180	COG0545	Peptidyl-prolyl cis-trans isomerase
GPY28_RS09195	COG1446	asparaginase
GPY28_RS09205	COG1047	Peptidyl-prolyl cis-trans
GPY28_RS09220	COG2249	NAD(P)H dehydrogenase (quinone) activity
GPY28_RS09225	COG0488	(ABC) transporter
GPY28_RS09235	COG0429	hydrolase of the alpha beta-hydrolase fold
GPY28_RS09245	COG3954	Phosphoribulokinase
GPY28_RS09250	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY28_RS09270	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GPY28_RS09275	COG0512	Glutamine amidotransferase of anthranilate synthase
GPY28_RS09280	COG1846	Transcriptional regulator
GPY28_RS09285	COG0697	spore germination
GPY28_RS09295	COG1473	amidohydrolase
GPY28_RS09300	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPY28_RS09305	COG0583	DNA-binding transcription factor activity
GPY28_RS09320	COG0180	Tryptophanyl-tRNA synthetase
GPY28_RS09325	COG0546	phosphoglycolate phosphatase activity
GPY28_RS09330	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPY28_RS09335	COG0557	exoribonuclease II activity
GPY28_RS09340	COG1959	2 iron, 2 sulfur cluster binding
GPY28_RS09345	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPY28_RS09345	COG1017	nitric oxide dioxygenase activity
GPY28_RS09350	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
GPY28_RS09360	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GPY28_RS09365	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
GPY28_RS09370	COG0330	HflC and HflK could
GPY28_RS09375	COG0330	HflC and HflK could
GPY28_RS09380	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GPY28_RS09390	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GPY28_RS09395	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GPY28_RS09405	COG0802	atpase or kinase
GPY28_RS09410	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GPY28_RS09475	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GPY28_RS09480	COG1162	GTPase activity
GPY28_RS09485	COG0688	phosphatidylethanolamine metabolic process
GPY28_RS09490	COG3273	potassium ion transport
GPY28_RS09490	COG0471	metal ion transport
GPY28_RS09500	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GPY28_RS09505	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY28_RS09510	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GPY28_RS09515	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GPY28_RS09520	COG1045	serine acetyltransferase
GPY28_RS09525	COG4942	peptidase
GPY28_RS09545	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
GPY28_RS09550	COG1053	succinate dehydrogenase
GPY28_RS09555	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GPY28_RS09560	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GPY28_RS09565	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GPY28_RS09580	COG1509	lysine 2,3-aminomutase activity
GPY28_RS09585	COG1285	pathogenesis
GPY28_RS09595	COG0459	protein refolding
GPY28_RS09600	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GPY28_RS09605	COG0534	Mate efflux family protein
GPY28_RS09610	COG0205	6-phosphofructokinase activity
GPY28_RS09615	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GPY28_RS09620	COG3678	ATP-independent chaperone mediated protein folding
GPY28_RS09625	COG0745	RESPONSE REGULATOR receiver
GPY28_RS09630	COG2205	protein histidine kinase activity
GPY28_RS09640	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GPY28_RS09645	COG3030	protein affecting phage T7 exclusion by the F plasmid
GPY28_RS09650	COG1027	Aspartate ammonia-lyase
GPY28_RS09655	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GPY28_RS09660	COG4232	protein-disulfide reductase activity
GPY28_RS09670	COG3263	regulation of cellular component size
GPY28_RS09680	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPY28_RS09705	COG2814	Major facilitator Superfamily
GPY28_RS09720	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPY28_RS09725	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GPY28_RS09730	COG0511	ligase activity, forming carbon-carbon bonds
GPY28_RS09735	COG0439	Biotin carboxylase
GPY28_RS09740	COG2264	protein methyltransferase activity
GPY28_RS09745	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPY28_RS09750	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GPY28_RS09760	COG0488	(ABC) transporter
GPY28_RS09810	COG1982	Orn Lys Arg decarboxylase major
GPY28_RS09815	COG0531	amino acid
GPY28_RS09825	COG3710	Transcriptional regulator
GPY28_RS09830	COG0789	Transcriptional regulator
GPY28_RS09845	COG0151	Belongs to the GarS family
GPY28_RS09860	COG1253	flavin adenine dinucleotide binding
GPY28_RS09865	COG3068	Protein conserved in bacteria
GPY28_RS09875	COG1573	uracil-dna glycosylase
GPY28_RS09880	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GPY28_RS09885	COG2816	NAD+ diphosphatase activity
GPY28_RS09890	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
GPY28_RS09895	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GPY28_RS09900	COG0085	RNA polymerase activity
GPY28_RS09905	COG0222	ribosome binding
GPY28_RS09910	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GPY28_RS09925	COG0250	Participates in transcription elongation, termination and antitermination
GPY28_RS09930	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GPY28_RS09940	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GPY28_RS09970	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
GPY28_RS09970	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
GPY28_RS09975	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GPY28_RS09985	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GPY28_RS10060	COG1943	Transposase
GPY28_RS10065	COG4206	TonB-dependent receptor
GPY28_RS10085	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY28_RS10090	COG0534	Mate efflux family protein
GPY28_RS10095	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
GPY28_RS10100	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GPY28_RS10105	COG2937	Belongs to the GPAT DAPAT family
GPY28_RS10110	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GPY28_RS10115	COG3161	chorismate lyase activity
GPY28_RS10120	COG1580	Controls the rotational direction of flagella during chemotaxis
GPY28_RS10125	COG0705	Rhomboid family
GPY28_RS10130	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY28_RS10140	COG2177	Part of the ABC transporter FtsEX involved in
GPY28_RS10145	COG2884	Cell division ATP-binding protein ftsE
GPY28_RS10150	COG0552	protein localization to endoplasmic reticulum
GPY28_RS10155	COG0742	ribosomal rna small subunit methyltransferase
GPY28_RS10165	COG2095	MarC family integral membrane protein
GPY28_RS10205	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPY28_RS10210	COG0640	Transcriptional regulator
GPY28_RS10215	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GPY28_RS10220	COG1280	lysine exporter protein (LysE YggA)
GPY28_RS10225	COG2267	carboxylic ester hydrolase activity
GPY28_RS10230	COG0561	phosphatase activity
GPY28_RS10250	COG2199	diguanylate cyclase activity
GPY28_RS10250	COG2200	EAL domain
GPY28_RS10250	COG3287	FIST C domain
GPY28_RS10255	COG1011	Hydrolase
GPY28_RS10260	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GPY28_RS10275	COG0019	diaminopimelate decarboxylase activity
GPY28_RS10285	COG1965	Belongs to the frataxin family
GPY28_RS10290	COG3072	Adenylate cyclase
GPY28_RS10295	COG0181	hydroxymethylbilane synthase activity
GPY28_RS10300	COG1587	Uroporphyrinogen-III synthase
GPY28_RS10305	COG2959	enzyme of heme biosynthesis
GPY28_RS10310	COG3071	HemY protein
GPY28_RS10315	COG1943	Transposase
GPY28_RS10360	COG0633	Ferredoxin
GPY28_RS10365	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GPY28_RS10375	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GPY28_RS10380	COG3118	belongs to the thioredoxin family
GPY28_RS10385	COG0513	Belongs to the DEAD box helicase family
GPY28_RS10390	COG0248	Ppx GppA phosphatase
GPY28_RS10400	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GPY28_RS10410	COG0514	ATP-dependent DNA helicase (RecQ)
GPY28_RS10415	COG2962	Rard protein
GPY28_RS10425	COG1280	lysine exporter protein (LysE YggA)
GPY28_RS10430	COG0405	Gamma-glutamyltransferase
GPY28_RS10440	COG1943	Transposase
GPY28_RS10445	COG0210	DNA helicase
GPY28_RS10455	COG3220	belongs to the UPF0276 family
GPY28_RS10485	COG0006	proline dipeptidase activity
GPY28_RS10485	COG0006	proline dipeptidase activity
GPY28_RS10500	COG2104	thiamine diphosphate biosynthetic process
GPY28_RS10505	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GPY28_RS10525	COG2132	Multicopper oxidase
GPY28_RS10580	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY28_RS10585	COG1739	Uncharacterized protein family UPF0029
GPY28_RS10595	COG0183	Belongs to the thiolase family
GPY28_RS10600	COG0604	alcohol dehydrogenase
GPY28_RS10615	COG0425	Belongs to the sulfur carrier protein TusA family
GPY28_RS10625	COG2119	membrane
GPY28_RS10640	COG0366	Alpha amylase catalytic
GPY28_RS10645	COG3977	Valine--pyruvate aminotransferase
GPY28_RS10650	COG0071	Belongs to the small heat shock protein (HSP20) family
GPY28_RS10665	COG0187	DNA topoisomerase II activity
GPY28_RS10675	COG0592	DNA-directed DNA polymerase activity
GPY28_RS10680	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GPY28_RS10700	COG1126	abc transporter atp-binding protein
GPY28_RS10710	COG0594	ribonuclease P activity
GPY28_RS10715	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GPY28_RS10720	COG0706	membrane insertase activity
GPY28_RS10730	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GPY28_RS10735	COG0445	tRNA wobble uridine modification
GPY28_RS10740	COG0357	Ribosomal RNA small subunit methyltransferase G
GPY28_RS10745	COG1192	Involved in chromosome partitioning
GPY28_RS10750	COG1475	DNA binding
GPY28_RS10755	COG3312	ion transport
GPY28_RS10760	COG0356	it plays a direct role in the translocation of protons across the membrane
GPY28_RS10770	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GPY28_RS10775	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GPY28_RS10780	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GPY28_RS10785	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GPY28_RS10790	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GPY28_RS10795	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GPY28_RS10805	COG0765	amino acid transport
GPY28_RS10815	COG2814	Major facilitator Superfamily
GPY28_RS10820	COG0583	DNA-binding transcription factor activity
GPY28_RS10830	COG0129	dihydroxy-acid dehydratase activity
GPY28_RS10835	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GPY28_RS10840	COG3978	acetolactate synthase activity
GPY28_RS10850	COG0606	chelatase, subunit chli
GPY28_RS10860	COG0204	Acyl-transferase
GPY28_RS10865	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPY28_RS10870	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GPY28_RS10880	COG3084	Protein conserved in bacteria
GPY28_RS10890	COG4326	sporulation control protein
GPY28_RS10895	COG1272	protein, Hemolysin III
GPY28_RS10905	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY28_RS10910	COG0569	domain protein
GPY28_RS10915	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GPY28_RS10915	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GPY28_RS10920	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GPY28_RS10925	COG0242	peptide deformylase activity
GPY28_RS10935	COG0758	DNA mediated transformation
GPY28_RS10940	COG2922	Belongs to the Smg family
GPY28_RS10945	COG0551	DNA topoisomerase type I activity
GPY28_RS10950	COG1943	Transposase
GPY28_RS10955	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GPY28_RS10960	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GPY28_RS10965	COG0009	L-threonylcarbamoyladenylate synthase
GPY28_RS10970	COG0408	coproporphyrinogen oxidase activity
GPY28_RS10985	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GPY28_RS11020	COG0583	DNA-binding transcription factor activity
GPY28_RS11025	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GPY28_RS11030	COG2960	long-chain fatty acid transporting porin activity
GPY28_RS11035	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY28_RS11040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY28_RS11095	COG4172	Belongs to the ABC transporter superfamily
GPY28_RS11100	COG4166	transmembrane transport
GPY28_RS11110	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY28_RS11150	COG1609	Transcriptional regulator
GPY28_RS11155	COG0583	DNA-binding transcription factor activity
GPY28_RS11165	COG2076	Multidrug Resistance protein
GPY28_RS11170	COG0129	dihydroxy-acid dehydratase activity
GPY28_RS11175	COG3265	gluconokinase activity
GPY28_RS11180	COG2610	gluconate transmembrane transporter activity
GPY28_RS11185	COG0800	Aldolase
GPY28_RS11190	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GPY28_RS11195	COG0583	DNA-binding transcription factor activity
GPY28_RS11200	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY28_RS11205	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GPY28_RS11215	COG1522	sequence-specific DNA binding
GPY28_RS11220	COG5002	protein histidine kinase activity
GPY28_RS11220	COG5001	Diguanylate cyclase
GPY28_RS11225	COG0742	ribosomal rna small subunit methyltransferase
GPY28_RS11235	COG0697	spore germination
GPY28_RS11240	COG0589	response to stress
GPY28_RS11245	COG1528	Iron-storage protein
GPY28_RS11255	COG2081	HI0933 family
GPY28_RS11285	COG1597	lipid kinase activity
GPY28_RS11315	COG0628	permease
GPY28_RS11330	COG1322	Protein conserved in bacteria
GPY28_RS11335	COG2226	methyltransferase
GPY28_RS11340	COG3165	ubiquinone biosynthetic process from chorismate
GPY28_RS11345	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GPY28_RS11360	COG0805	protein transport
GPY28_RS11370	COG0084	hydrolase, TatD family'
GPY28_RS11385	COG0456	acetyltransferase
GPY28_RS11395	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPY28_RS11395	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPY28_RS11400	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GPY28_RS11430	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GPY28_RS11435	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GPY28_RS11445	COG2204	response regulator
GPY28_RS11450	COG3852	Histidine kinase
GPY28_RS11460	COG0174	glutamine synthetase
GPY28_RS11470	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GPY28_RS11480	COG1295	ribonuclease BN
GPY28_RS11485	COG1490	D-aminoacyl-tRNA deacylase activity
GPY28_RS11490	COG0456	acetyltransferase
GPY28_RS11500	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GPY28_RS11505	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GPY28_RS11510	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GPY28_RS11515	COG3031	protein transport across the cell outer membrane
GPY28_RS11525	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY28_RS11530	COG1459	type II secretion system
GPY28_RS11535	COG2165	general secretion pathway protein
GPY28_RS11540	COG2165	general secretion pathway protein
GPY28_RS11545	COG2165	general secretion pathway protein
GPY28_RS11550	COG4795	General secretion pathway protein
GPY28_RS11555	COG3156	type II secretion system protein K
GPY28_RS11560	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GPY28_RS11565	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GPY28_RS11575	COG1218	3'(2'),5'-bisphosphate nucleotidase
GPY28_RS11580	COG0494	nUDIX hydrolase
GPY28_RS11590	COG1040	competence protein
GPY28_RS11605	COG2183	response to ionizing radiation
GPY28_RS11615	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY28_RS11625	COG0745	RESPONSE REGULATOR receiver
GPY28_RS11635	COG2233	PERMEase
GPY28_RS11640	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GPY28_RS11645	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPY28_RS11650	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GPY28_RS11655	COG1758	RNA polymerase activity
GPY28_RS11660	COG0194	GDP metabolic process
GPY28_RS11675	COG0848	biopolymer transport protein
GPY28_RS11680	COG0811	peptide transport
GPY28_RS11705	COG4174	ABC transporter (Permease)
GPY28_RS11710	COG4239	(ABC) transporter, permease
GPY28_RS11715	COG0747	negative chemotaxis
GPY28_RS11720	COG0444	Belongs to the ABC transporter superfamily
GPY28_RS11725	COG4608	Belongs to the ABC transporter superfamily
GPY28_RS11735	COG1561	YicC-like family, N-terminal region
GPY28_RS11740	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GPY28_RS11750	COG1943	Transposase
GPY28_RS11755	COG1560	Kdo2-lipid A biosynthetic process
GPY28_RS11760	COG1309	transcriptional regulator
GPY28_RS11765	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GPY28_RS11775	COG2003	Belongs to the UPF0758 family
GPY28_RS11820	COG0463	Glycosyl transferase, family 2
GPY28_RS11825	COG0859	PFAM glycosyl transferase family 9
GPY28_RS11830	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GPY28_RS11835	COG3642	lipopolysaccharide core region biosynthetic process
GPY28_RS11855	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GPY28_RS11870	COG1519	Transferase
GPY28_RS11875	COG0859	PFAM glycosyl transferase family 9
GPY28_RS11880	COG1560	Kdo2-lipid A biosynthetic process
GPY28_RS11890	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY28_RS11930	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GPY28_RS11935	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GPY28_RS11940	COG2089	acid synthase
GPY28_RS11950	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GPY28_RS11955	COG1083	cytidylyl-transferase
GPY28_RS11965	COG1442	glycosyl transferase family 8
GPY28_RS11965	COG1216	Glycosyl transferase, family 2
GPY28_RS11970	COG0728	peptidoglycan biosynthetic process
GPY28_RS11985	COG1181	Belongs to the D-alanine--D-alanine ligase family
GPY28_RS11995	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPY28_RS12015	COG0149	triose-phosphate isomerase activity
GPY28_RS12045	COG1494	fructose-1,6-bisphosphatase
GPY28_RS12055	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GPY28_RS12060	COG1575	Belongs to the MenA family. Type 1 subfamily
GPY28_RS12065	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GPY28_RS12070	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GPY28_RS12080	COG1609	Transcriptional regulator
GPY28_RS12085	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GPY28_RS12095	COG0254	rRNA binding
GPY28_RS12105	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GPY28_RS12110	COG0088	Forms part of the polypeptide exit tunnel
GPY28_RS12120	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GPY28_RS12125	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GPY28_RS12130	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GPY28_RS12135	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GPY28_RS12145	COG0255	Belongs to the universal ribosomal protein uL29 family
GPY28_RS12150	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GPY28_RS12160	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GPY28_RS12165	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GPY28_RS12175	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GPY28_RS12180	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GPY28_RS12195	COG1841	ribosomal large subunit assembly
GPY28_RS12205	COG0201	protein transport
GPY28_RS12215	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GPY28_RS12220	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GPY28_RS12230	COG0202	RNA polymerase activity
GPY28_RS12235	COG0203	ribosomal protein L17
GPY28_RS12245	COG0545	Peptidyl-prolyl cis-trans isomerase
GPY28_RS12255	COG2153	protein acetylation
GPY28_RS12260	COG0513	Belongs to the DEAD box helicase family
GPY28_RS12270	COG0737	Belongs to the 5'-nucleotidase family
GPY28_RS12275	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GPY28_RS12275	COG1648	precorrin-2 dehydrogenase activity
GPY28_RS12280	COG0175	sulfate reduction
GPY28_RS12285	COG2895	sulfate adenylyltransferase (ATP) activity
GPY28_RS12290	COG0471	metal ion transport
GPY28_RS12290	COG3273	potassium ion transport
GPY28_RS12295	COG0529	Catalyzes the synthesis of activated sulfate
GPY28_RS12315	COG4181	ATPase activity
GPY28_RS12330	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
GPY28_RS12340	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY28_RS12345	COG0729	surface antigen
GPY28_RS12350	COG2911	Protein conserved in bacteria
GPY28_RS12355	COG2105	PFAM AIG2 family protein
GPY28_RS12365	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GPY28_RS12370	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GPY28_RS12380	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GPY28_RS12385	COG0163	prenyltransferase activity
GPY28_RS12390	COG4143	(ABC) transporter
GPY28_RS12395	COG1178	ABC-type Fe3 transport system permease component
GPY28_RS12400	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
GPY28_RS12405	COG0583	DNA-binding transcription factor activity
GPY28_RS12410	COG1902	pentaerythritol trinitrate reductase activity
GPY28_RS12450	COG0142	geranyltranstransferase activity
GPY28_RS12455	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GPY28_RS12465	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GPY28_RS12470	COG2966	Psort location CytoplasmicMembrane, score
GPY28_RS12480	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GPY28_RS12485	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GPY28_RS12490	COG2967	ApaG domain
GPY28_RS12495	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GPY28_RS12500	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GPY28_RS12505	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPY28_RS12510	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GPY28_RS12515	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GPY28_RS12535	COG0473	3-isopropylmalate dehydrogenase activity
GPY28_RS12540	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GPY28_RS12565	COG0583	DNA-binding transcription factor activity
GPY28_RS12570	COG1022	Amp-dependent synthetase and ligase
GPY28_RS12575	COG0028	Belongs to the TPP enzyme family
GPY28_RS12580	COG0440	acetolactate synthase activity
GPY28_RS12585	COG3706	GGDEF domain
GPY28_RS12595	COG0469	pyruvate kinase activity
GPY28_RS12600	COG1349	DNA-binding transcription factor activity
GPY28_RS12605	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GPY28_RS12615	COG2376	Dihydroxyacetone kinase
GPY28_RS12620	COG1461	Dihydroxyacetone kinase
GPY28_RS12635	COG3722	fumarate hydratase activity
GPY28_RS12645	COG2213	PTS system mannitol-specific
GPY28_RS12645	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY28_RS12710	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPY28_RS12715	COG0358	DNA primase activity
GPY28_RS12720	COG1610	YqeY-like protein
GPY28_RS12725	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GPY28_RS12730	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GPY28_RS12735	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GPY28_RS12740	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GPY28_RS12745	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GPY28_RS12750	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GPY28_RS12755	COG1968	undecaprenyl-diphosphatase activity
GPY28_RS12765	COG3409	Peptidoglycan-binding domain 1 protein
GPY28_RS12765	COG3267	Type II secretory pathway component ExeA
GPY28_RS12775	COG0405	Gamma-glutamyltransferase
GPY28_RS12780	COG4991	sh3 domain protein
GPY28_RS12785	COG0306	phosphate transporter
GPY28_RS12790	COG1392	Phosphate transport regulator
GPY28_RS12795	COG3025	triphosphatase activity
GPY28_RS12810	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GPY28_RS12815	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GPY28_RS12815	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GPY28_RS12820	COG1538	Outer membrane efflux protein
GPY28_RS12825	COG0494	nUDIX hydrolase
GPY28_RS12830	COG3151	Protein conserved in bacteria
GPY28_RS12840	COG3150	esterase
GPY28_RS12845	COG0187	DNA topoisomerase II activity
GPY28_RS12850	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GPY28_RS12855	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GPY28_RS12865	COG3105	Protein conserved in bacteria
GPY28_RS12875	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GPY28_RS12890	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GPY28_RS12895	COG0723	plastoquinol--plastocyanin reductase activity
GPY28_RS12900	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GPY28_RS12905	COG2857	Cytochrome c1
GPY28_RS12910	COG0625	glutathione transferase activity
GPY28_RS12915	COG2969	positive regulation of protein catabolic process
GPY28_RS12920	COG2823	Periplasmic or secreted lipoprotein
GPY28_RS12925	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GPY28_RS12940	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GPY28_RS12960	COG3116	cell division
GPY28_RS12965	COG0768	penicillin binding
GPY28_RS12970	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GPY28_RS12975	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GPY28_RS12980	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GPY28_RS12985	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GPY28_RS12990	COG0772	Belongs to the SEDS family
GPY28_RS13005	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GPY28_RS13010	COG0849	cell division
GPY28_RS13015	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GPY28_RS13020	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GPY28_RS13030	COG0653	protein targeting
GPY28_RS13035	COG0494	nUDIX hydrolase
GPY28_RS13045	COG0505	Belongs to the CarA family
GPY28_RS13050	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GPY28_RS13065	COG0730	response to heat
GPY28_RS13070	COG0583	DNA-binding transcription factor activity
GPY28_RS13075	COG2860	membrane
GPY28_RS13090	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GPY28_RS13100	COG0493	'glutamate synthase
GPY28_RS13105	COG0067	glutamate synthase
GPY28_RS13105	COG0069	glutamate synthase activity
GPY28_RS13105	COG0070	glutamate synthase
GPY28_RS13115	COG0070	glutamate synthase
GPY28_RS13115	COG0069	glutamate synthase activity
GPY28_RS13115	COG0067	glutamate synthase
GPY28_RS13120	COG1242	4 iron, 4 sulfur cluster binding
GPY28_RS13125	COG5001	Diguanylate cyclase
GPY28_RS13125	COG4251	negative regulation of phosphorylation
GPY28_RS13125	COG3706	GGDEF domain
GPY28_RS13125	COG2203	Gaf domain
GPY28_RS13130	COG5002	protein histidine kinase activity
GPY28_RS13130	COG0784	Response regulator, receiver
GPY28_RS13130	COG2198	Histidine kinase
GPY28_RS13140	COG0745	RESPONSE REGULATOR receiver
GPY28_RS13155	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GPY28_RS13175	COG0083	homoserine kinase activity
GPY28_RS13180	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GPY28_RS13190	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
GPY28_RS13195	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GPY28_RS13205	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GPY28_RS13220	COG1115	amino acid carrier protein
GPY28_RS13225	COG3022	response to hydroperoxide
GPY28_RS13230	COG0513	Belongs to the DEAD box helicase family
GPY28_RS13235	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GPY28_RS13245	COG0716	FMN binding
GPY28_RS13255	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPY28_RS13260	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GPY28_RS13275	COG2204	response regulator
GPY28_RS13285	COG0667	Aldo Keto reductase
GPY28_RS13315	COG0730	response to heat
GPY28_RS13325	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GPY28_RS13335	COG1283	sodium-dependent phosphate transmembrane transporter activity
GPY28_RS13340	COG0583	DNA-binding transcription factor activity
GPY28_RS13345	COG0640	Transcriptional regulator
GPY28_RS13350	COG1943	Transposase
GPY28_RS13355	COG0268	Binds directly to 16S ribosomal RNA
GPY28_RS13360	COG0728	peptidoglycan biosynthetic process
GPY28_RS13365	COG0196	riboflavin kinase activity
GPY28_RS13380	COG1047	Peptidyl-prolyl cis-trans
GPY28_RS13385	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GPY28_RS13395	COG3279	Response regulator of the LytR AlgR family
GPY28_RS13400	COG3275	phosphorelay sensor kinase activity
GPY28_RS13405	COG1966	Carbon starvation protein
GPY28_RS13425	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GPY28_RS13430	COG1472	Belongs to the glycosyl hydrolase 3 family
GPY28_RS13435	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY28_RS13440	COG0287	Prephenate dehydrogenase
GPY28_RS13440	COG1605	Chorismate mutase
GPY28_RS13445	COG0739	heme binding
GPY28_RS13455	COG0488	(ABC) transporter
GPY28_RS13465	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
GPY28_RS13470	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
GPY28_RS13475	COG1605	Chorismate mutase
GPY28_RS13475	COG0077	Prephenate dehydratase
GPY28_RS13480	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GPY28_RS13490	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY28_RS13495	COG0564	pseudouridine synthase activity
GPY28_RS13505	COG0542	response to heat
GPY28_RS13565	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GPY28_RS13575	COG2974	May be involved in recombination
GPY28_RS13580	COG0745	RESPONSE REGULATOR receiver
GPY28_RS13585	COG5002	protein histidine kinase activity
GPY28_RS13595	COG0248	Ppx GppA phosphatase
GPY28_RS13600	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GPY28_RS13605	COG0573	inorganic phosphate transmembrane transporter activity
GPY28_RS13610	COG0581	inorganic phosphate transmembrane transporter activity
GPY28_RS13615	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GPY28_RS13620	COG0704	Plays a role in the regulation of phosphate uptake
GPY28_RS13630	COG3142	Participates in the control of copper homeostasis
GPY28_RS13635	COG0450	alkyl hydroperoxide reductase
GPY28_RS13640	COG0583	DNA-binding transcription factor activity
GPY28_RS13650	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GPY28_RS13660	COG0517	IMP dehydrogenase activity
GPY28_RS13670	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GPY28_RS13680	COG1862	Preprotein translocase
GPY28_RS13685	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY28_RS13690	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY28_RS13705	COG0483	inositol monophosphate 1-phosphatase activity
GPY28_RS13710	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
GPY28_RS13720	COG1104	cysteine desulfurase activity
GPY28_RS13725	COG0822	iron-sulfur transferase activity
GPY28_RS13740	COG0443	Heat shock 70 kDa protein
GPY28_RS13745	COG0633	Ferredoxin
GPY28_RS13750	COG2975	iron-sulfur cluster assembly
GPY28_RS13760	COG0105	UTP biosynthetic process
GPY28_RS13775	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GPY28_RS13780	COG0124	histidyl-tRNA synthetase
GPY28_RS13785	COG2976	Protein conserved in bacteria
GPY28_RS13790	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY28_RS13795	COG1160	GTP binding
GPY28_RS13815	COG0517	IMP dehydrogenase activity
GPY28_RS13815	COG0516	GMP reductase activity
GPY28_RS13825	COG1757	Na H antiporter
GPY28_RS13835	COG1584	GPR1 FUN34 yaaH family protein
GPY28_RS13840	COG1115	amino acid carrier protein
GPY28_RS13855	COG2873	o-acetylhomoserine
GPY28_RS13860	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GPY28_RS13880	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GPY28_RS13880	COG3153	acetyltransferase
GPY28_RS13885	COG0583	DNA-binding transcription factor activity
GPY28_RS13925	COG0328	RNA-DNA hybrid ribonuclease activity
GPY28_RS13940	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GPY28_RS13945	COG2867	negative regulation of translational initiation
GPY28_RS13950	COG2914	Belongs to the UPF0125 (RnfH) family
GPY28_RS13955	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY28_RS13965	COG0497	DNA recombination
GPY28_RS13975	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GPY28_RS13980	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GPY28_RS13985	COG1301	dicarboxylic acid transport
GPY28_RS13995	COG0484	heat shock protein binding
GPY28_RS14030	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPY28_RS14035	COG0590	tRNA wobble adenosine to inosine editing
GPY28_RS14045	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GPY28_RS14050	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GPY28_RS14050	COG0047	phosphoribosylformylglycinamidine synthase activity
GPY28_RS14080	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPY28_RS14085	COG2252	PERMEase
GPY28_RS14090	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
GPY28_RS14105	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GPY28_RS14110	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GPY28_RS14115	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GPY28_RS14120	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPY28_RS14120	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPY28_RS14145	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GPY28_RS14150	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GPY28_RS14155	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GPY28_RS14160	COG0142	geranyltranstransferase activity
GPY28_RS14165	COG1722	exodeoxyribonuclease VII activity
GPY28_RS14170	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GPY28_RS14180	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY28_RS14180	COG0301	tRNA thio-modification
GPY28_RS14185	COG0583	DNA-binding transcription factor activity
GPY28_RS14195	COG2363	Small membrane protein
GPY28_RS14205	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPY28_RS14210	COG1611	Belongs to the LOG family
GPY28_RS14215	COG0745	RESPONSE REGULATOR receiver
GPY28_RS14215	COG3706	GGDEF domain
GPY28_RS14225	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GPY28_RS14225	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GPY28_RS14235	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
GPY28_RS14240	COG1464	Belongs to the NlpA lipoprotein family
GPY28_RS14245	COG2011	ABC-type metal ion transport system permease component
GPY28_RS14250	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GPY28_RS14255	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GPY28_RS14265	COG1263	PTS System
GPY28_RS14265	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY28_RS14270	COG0366	Alpha amylase catalytic
GPY28_RS14285	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GPY28_RS14290	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GPY28_RS14295	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GPY28_RS14300	COG0321	lipoyl(octanoyl) transferase activity
GPY28_RS14310	COG1686	Belongs to the peptidase S11 family
GPY28_RS14315	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GPY28_RS14320	COG0772	Belongs to the SEDS family
GPY28_RS14325	COG0768	penicillin binding
GPY28_RS14330	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GPY28_RS14335	COG0799	negative regulation of ribosome biogenesis
GPY28_RS14340	COG1466	dna polymerase III delta subunit
GPY28_RS14345	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
GPY28_RS14350	COG0495	leucyl-tRNA aminoacylation
GPY28_RS14355	COG2888	peptidyl-tyrosine sulfation
GPY28_RS14360	COG1943	Transposase
GPY28_RS14365	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GPY28_RS14370	COG4535	Mg2 and Co2 transporter CorC
GPY28_RS14375	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GPY28_RS14380	COG1702	phosphate starvation-inducible protein PhoH
GPY28_RS14385	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GPY28_RS14395	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPY28_RS14505	COG0012	GTP binding
GPY28_RS14510	COG0193	aminoacyl-tRNA hydrolase activity
GPY28_RS14515	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GPY28_RS14520	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GPY28_RS14525	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
GPY28_RS14530	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GPY28_RS14540	COG2890	protein-(glutamine-N5) methyltransferase activity
GPY28_RS14545	COG3094	Invasion gene expression up-regulator, SirB
GPY28_RS14550	COG2912	Transglutaminase-like superfamily
GPY28_RS14555	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GPY28_RS14560	COG0737	Belongs to the 5'-nucleotidase family
GPY28_RS14565	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GPY28_RS14570	COG1187	pseudouridine synthase activity
GPY28_RS14575	COG2840	Smr protein MutS2
GPY28_RS14615	COG2217	Heavy metal translocating P-type atpase
GPY28_RS14615	COG2608	mercury ion transmembrane transporter activity
GPY28_RS14630	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GPY28_RS14685	COG0784	Response regulator, receiver
GPY28_RS14685	COG0835	chemotaxis
GPY28_RS14690	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GPY28_RS14695	COG1943	Transposase
GPY28_RS14700	COG1815	bacterial-type flagellum-dependent cell motility
GPY28_RS14705	COG1558	bacterial-type flagellum-dependent cell motility
GPY28_RS14710	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GPY28_RS14715	COG1749	Flagellar hook protein flgE
GPY28_RS14720	COG4787	bacterial-type flagellum-dependent cell motility
GPY28_RS14725	COG4786	Flagellar basal body rod
GPY28_RS14730	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GPY28_RS14735	COG1706	bacterial-type flagellum-dependent cell motility
GPY28_RS14740	COG3951	Flagellar rod assembly protein muramidase FlgJ
GPY28_RS14740	COG1705	Flagellar rod assembly protein muramidase FlgJ
GPY28_RS14750	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY28_RS14755	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY28_RS14765	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY28_RS14770	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY28_RS14780	COG2190	(PTS) system
GPY28_RS14785	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GPY28_RS14790	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY28_RS14800	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GPY28_RS14805	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
GPY28_RS14810	COG3115	cell septum assembly
GPY28_RS14815	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GPY28_RS14835	COG0330	HflC and HflK could
GPY28_RS14840	COG3118	belongs to the thioredoxin family
GPY28_RS14850	COG0300	oxidoreductase activity
GPY28_RS14855	COG1090	epimerase
GPY28_RS14885	COG0622	Phosphoesterase
GPY28_RS14905	COG3710	Transcriptional regulator
GPY28_RS14910	COG0326	Molecular chaperone. Has ATPase activity
GPY28_RS14920	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GPY28_RS14925	COG3104	oligopeptide transport
GPY28_RS14930	COG0250	Participates in transcription elongation, termination and antitermination
GPY28_RS14935	COG0367	asparagine synthase
GPY28_RS14940	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GPY28_RS14940	COG4651	solute:proton antiporter activity
GPY28_RS14945	COG1940	carbohydrate kinase activity
GPY28_RS14945	COG1846	Transcriptional regulator
GPY28_RS14950	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GPY28_RS14960	COG1263	PTS System
GPY28_RS14960	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY28_RS14960	COG2190	(PTS) system
GPY28_RS14965	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPY28_RS14970	COG0735	belongs to the Fur family
GPY28_RS14980	COG0716	FMN binding
GPY28_RS14990	COG0596	Alpha beta hydrolase
GPY28_RS14995	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
GPY28_RS15000	COG0033	Phosphoglucomutase
GPY28_RS15010	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GPY28_RS15020	COG2009	succinate dehydrogenase
GPY28_RS15025	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GPY28_RS15030	COG1053	succinate dehydrogenase
GPY28_RS15035	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GPY28_RS15040	COG0567	Dehydrogenase, E1 component
GPY28_RS15045	COG0508	dehydrogenase complex catalyzes the overall conversion of
GPY28_RS15050	COG0045	succinate-CoA ligase (ADP-forming) activity
GPY28_RS15060	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GPY28_RS15065	COG1121	(ABC) transporter
GPY28_RS15070	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
GPY28_RS15080	COG1918	ferrous iron import across plasma membrane
GPY28_RS15105	COG0018	arginyl-trna synthetase
GPY28_RS15115	COG3102	Protein conserved in bacteria
GPY28_RS15120	COG0788	formyltetrahydrofolate deformylase activity
GPY28_RS15125	COG1199	ATP-dependent helicase activity
GPY28_RS15130	COG1214	PFAM Peptidase M22, glycoprotease
GPY28_RS15140	COG3065	identical protein binding
GPY28_RS15145	COG2267	carboxylic ester hydrolase activity
GPY28_RS15150	COG0318	PFAM AMP-dependent synthetase and ligase
GPY28_RS15155	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GPY28_RS15165	COG2894	cell division
GPY28_RS15170	COG0850	regulation of cytokinetic process
GPY28_RS15175	COG3100	YcgL domain-containing protein
GPY28_RS15180	COG2951	lytic endotransglycosylase activity
GPY28_RS15190	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPY28_RS15195	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GPY28_RS15205	COG2226	methyltransferase
GPY28_RS15210	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPY28_RS15215	COG1028	Short-chain dehydrogenase reductase Sdr
GPY28_RS15220	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPY28_RS15225	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPY28_RS15250	COG2986	histidine ammonia-lyase
GPY28_RS15255	COG1216	Glycosyl transferase, family 2
GPY28_RS15260	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPY28_RS15275	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GPY28_RS15280	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GPY28_RS15315	COG0513	Belongs to the DEAD box helicase family
GPY28_RS15320	COG0569	domain protein
GPY28_RS15325	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY28_RS15340	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GPY28_RS15345	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GPY28_RS15350	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GPY28_RS15355	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GPY28_RS15370	COG0544	peptidyl-prolyl cis-trans isomerase activity
GPY28_RS15380	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GPY28_RS15385	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GPY28_RS15390	COG0776	regulation of translation
GPY28_RS15395	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPY28_RS15400	COG1555	photosystem II stabilization
GPY28_RS15415	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GPY28_RS15420	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
GPY28_RS15425	COG0436	Aminotransferase
GPY28_RS15430	COG1169	isochorismate synthase
GPY28_RS15435	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GPY28_RS15445	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GPY28_RS15450	COG1441	menaquinone biosynthetic process
GPY28_RS15465	COG2855	membrane
GPY28_RS15470	COG0477	Major facilitator Superfamily
GPY28_RS15515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY28_RS15520	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY28_RS15535	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GPY28_RS15540	COG1522	sequence-specific DNA binding
GPY28_RS15550	COG1946	Acyl-CoA thioesterase
GPY28_RS15555	COG3126	Type III secretion system lipoprotein chaperone (YscW)
GPY28_RS15570	COG3706	GGDEF domain
GPY28_RS15655	COG2200	EAL domain
GPY28_RS15660	COG2226	methyltransferase
GPY28_RS15695	COG0210	DNA helicase
GPY28_RS15750	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPY28_RS15755	COG0517	IMP dehydrogenase activity
GPY28_RS15755	COG0516	GMP reductase activity
GPY28_RS15780	COG0537	adenosine 5'-monophosphoramidase activity
GPY28_RS15805	COG3150	esterase
GPY28_RS15810	COG1252	NADH dehydrogenase
GPY28_RS15825	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GPY28_RS15835	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPY28_RS15840	COG1136	(ABC) transporter
GPY28_RS15845	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPY28_RS15855	COG2333	competence protein COMEC
GPY28_RS15855	COG0658	competence protein
GPY28_RS15860	COG1132	(ABC) transporter
GPY28_RS15880	COG2719	SpoVR family
GPY28_RS15885	COG2718	Belongs to the UPF0229 family
GPY28_RS15890	COG2766	serine protein kinase
GPY28_RS15895	COG3013	Belongs to the UPF0304 family
GPY28_RS15905	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GPY28_RS15915	COG1882	Formate acetyltransferase
GPY28_RS15945	COG4215	(ABC) transporter
GPY28_RS15960	COG0708	Exodeoxyribonuclease III
GPY28_RS15970	COG3923	Primosomal replication protein n
GPY28_RS15975	COG0730	response to heat
GPY28_RS15980	COG1199	ATP-dependent helicase activity
GPY28_RS15985	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPY28_RS15990	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GPY28_RS15995	COG1187	pseudouridine synthase activity
GPY28_RS16005	COG1278	Cold shock
GPY28_RS16010	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GPY28_RS16015	COG0542	response to heat
GPY28_RS16020	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GPY28_RS16025	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
GPY28_RS16030	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GPY28_RS16050	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GPY28_RS16055	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GPY28_RS16060	COG0297	glycogen (starch) synthase activity
GPY28_RS16080	COG3070	regulator of competence-specific genes
GPY28_RS16085	COG1609	Transcriptional regulator
GPY28_RS16090	COG3381	protein complex oligomerization
GPY28_RS16095	COG0745	RESPONSE REGULATOR receiver
GPY28_RS16100	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GPY28_RS16105	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPY28_RS16110	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
GPY28_RS16115	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
GPY28_RS16120	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GPY28_RS16140	COG4067	protein conserved in archaea
GPY28_RS16140	COG0189	ligase activity
GPY28_RS16150	COG0500	methyltransferase
GPY28_RS16160	COG1801	Protein of unknown function DUF72
GPY28_RS16170	COG0217	transcriptional regulatory protein
GPY28_RS16175	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GPY28_RS16180	COG0632	four-way junction helicase activity
GPY28_RS16185	COG2255	four-way junction helicase activity
GPY28_RS16190	COG1271	oxidase subunit
GPY28_RS16195	COG1294	oxidase, subunit
GPY28_RS16200	COG4890	Cyd operon protein YbgT
GPY28_RS16210	COG0824	Thioesterase
GPY28_RS16215	COG0811	peptide transport
GPY28_RS16230	COG0823	Involved in the tonB-independent uptake of proteins
GPY28_RS16235	COG2885	chlorophyll binding
GPY28_RS16240	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
GPY28_RS16245	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GPY28_RS16255	COG3766	membrane
GPY28_RS16265	COG0754	glutathionylspermidine amidase activity
GPY28_RS16275	COG5002	protein histidine kinase activity
GPY28_RS16275	COG0784	Response regulator, receiver
GPY28_RS16290	COG1294	oxidase, subunit
GPY28_RS16295	COG1271	oxidase subunit
GPY28_RS16315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY28_RS16320	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY28_RS16345	COG3568	Endonuclease Exonuclease Phosphatase
GPY28_RS16370	COG0583	DNA-binding transcription factor activity
GPY28_RS16380	COG0686	Belongs to the AlaDH PNT family
GPY28_RS16390	COG1674	ftsk spoiiie
GPY28_RS16400	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GPY28_RS16420	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GPY28_RS16425	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GPY28_RS16445	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GPY28_RS16465	COG0300	oxidoreductase activity
GPY28_RS16480	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GPY28_RS16490	COG2268	Band 7 protein
GPY28_RS16500	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GPY28_RS16505	COG2915	High frequency lysogenization protein hflD homolog
GPY28_RS16520	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY28_RS16530	COG1757	Na H antiporter
GPY28_RS16540	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GPY28_RS16550	COG0131	Imidazoleglycerol-phosphate dehydratase
GPY28_RS16550	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GPY28_RS16555	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GPY28_RS16560	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GPY28_RS16565	COG0107	imidazoleglycerol-phosphate synthase activity
GPY28_RS16570	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GPY28_RS16570	COG0140	phosphoribosyl-ATP diphosphatase activity
GPY28_RS16575	COG3012	SEC-C Motif Domain Protein
GPY28_RS16580	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GPY28_RS16585	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY28_RS16590	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GPY28_RS16595	COG0215	cysteine-tRNA ligase activity
GPY28_RS16600	COG1435	thymidine kinase activity
GPY28_RS16605	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GPY28_RS16630	COG2116	formate transmembrane transporter activity
GPY28_RS16640	COG0390	transport system, permease component
GPY28_RS16645	COG4459	periplasmic nitrate reductase
GPY28_RS16650	COG3005	denitrification pathway
GPY28_RS16655	COG0243	molybdopterin cofactor binding
GPY28_RS16670	COG1227	inorganic diphosphatase activity
GPY28_RS16680	COG4172	Belongs to the ABC transporter superfamily
GPY28_RS16690	COG4171	peptide transport system, permease
GPY28_RS16695	COG4168	peptide transport system, permease
GPY28_RS16705	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GPY28_RS16710	COG1842	Phage shock protein A
GPY28_RS16720	COG1983	PspC domain protein
GPY28_RS16740	COG2818	Glycosylase
GPY28_RS16745	COG5380	lipid catabolic process
GPY28_RS16750	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GPY28_RS16755	COG0626	cystathionine gamma-synthase activity
GPY28_RS16765	COG0733	neurotransmitter:sodium symporter activity
GPY28_RS16770	COG0564	pseudouridine synthase activity
GPY28_RS16780	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPY28_RS16785	COG1151	hydroxylamine reductase activity
GPY28_RS16790	COG3604	Transcriptional regulator
GPY28_RS16805	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GPY28_RS16810	COG4136	ATPase activity
GPY28_RS16815	COG4135	transport system, permease component
GPY28_RS16820	COG4134	Bacterial extracellular solute-binding protein
GPY28_RS16830	COG3313	Fe-S protein
GPY28_RS16855	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GPY28_RS16860	COG2205	protein histidine kinase activity
GPY28_RS16865	COG0745	RESPONSE REGULATOR receiver
GPY28_RS16875	COG1061	Type III restriction enzyme res subunit
GPY28_RS16880	COG1187	pseudouridine synthase activity
GPY28_RS16885	COG2814	Major facilitator Superfamily
GPY28_RS16895	COG0702	epimerase
GPY28_RS16900	COG0534	Mate efflux family protein
GPY28_RS16920	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GPY28_RS16930	COG1960	acyl-CoA dehydrogenase activity
GPY28_RS16935	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GPY28_RS16940	COG3273	potassium ion transport
GPY28_RS16940	COG2985	domain, Protein
GPY28_RS16945	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPY28_RS16955	COG1737	Transcriptional regulator
GPY28_RS16960	COG0076	glutamate decarboxylase activity
GPY28_RS16970	COG2431	L-lysine efflux transmembrane transporter activity
GPY28_RS16985	COG3070	regulator of competence-specific genes
GPY28_RS17000	COG4191	Histidine kinase
GPY28_RS17000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY28_RS17010	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GPY28_RS17020	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GPY28_RS17025	COG4988	ABC transporter
GPY28_RS17030	COG0492	ferredoxin-NADP+ reductase activity
GPY28_RS17050	COG3706	GGDEF domain
GPY28_RS17050	COG0745	RESPONSE REGULATOR receiver
GPY28_RS17055	COG0471	metal ion transport
GPY28_RS17060	COG2949	membrane
GPY28_RS17065	COG0281	malic enzyme
GPY28_RS17085	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GPY28_RS17195	COG0247	lactate metabolic process
GPY28_RS17195	COG0277	FAD linked oxidase domain protein
GPY28_RS17210	COG2986	histidine ammonia-lyase
GPY28_RS17215	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GPY28_RS17220	COG0010	Belongs to the arginase family
GPY28_RS17225	COG1228	amidohydrolase
GPY28_RS17245	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GPY28_RS17255	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GPY28_RS17265	COG0393	Putative heavy-metal-binding
GPY28_RS17300	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GPY28_RS17305	COG0072	phenylalanine-tRNA ligase activity
GPY28_RS17305	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY28_RS17315	COG0776	regulation of translation
GPY28_RS17325	COG0500	methyltransferase
GPY28_RS17330	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GPY28_RS17335	COG0295	cytidine deaminase activity
GPY28_RS17340	COG1346	cytolysis
GPY28_RS17345	COG1380	Effector of murein hydrolase LrgA
GPY28_RS17350	COG2925	Exonuclease
GPY28_RS17360	COG0702	epimerase
GPY28_RS17365	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GPY28_RS17370	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
GPY28_RS17390	COG2988	succinylglutamate desuccinylase activity
GPY28_RS17395	COG4139	cobalamin transport
GPY28_RS17400	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
GPY28_RS17420	COG0583	DNA-binding transcription factor activity
GPY28_RS17430	COG1451	nucleotide metabolic process
GPY28_RS17465	COG3938	Belongs to the proline racemase family
GPY28_RS17480	COG2423	ornithine cyclodeaminase activity
GPY28_RS17485	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GPY28_RS17490	COG3842	ATPase activity
GPY28_RS17495	COG1176	ABC-type spermidine putrescine transport system, permease component I
GPY28_RS17500	COG1177	transmembrane transport
GPY28_RS17510	COG3291	Pkd domain containing protein
GPY28_RS17530	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY28_RS17535	COG0601	transmembrane transport
GPY28_RS17545	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPY28_RS17555	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GPY28_RS17565	COG0625	glutathione transferase activity
GPY28_RS17615	COG3755	Protein conserved in bacteria
GPY28_RS17640	COG1742	UPF0060 membrane protein
GPY28_RS17655	COG1757	Na H antiporter
GPY28_RS17660	COG0174	glutamine synthetase
GPY28_RS17670	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GPY28_RS17675	COG1917	Cupin 2, conserved barrel domain protein
GPY28_RS17675	COG1396	sequence-specific DNA binding
GPY28_RS17680	COG1012	belongs to the aldehyde dehydrogenase family
GPY28_RS17685	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPY28_RS17695	COG2957	Belongs to the agmatine deiminase family
GPY28_RS17700	COG1012	belongs to the aldehyde dehydrogenase family
GPY28_RS17705	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GPY28_RS17710	COG2200	EAL domain
GPY28_RS17720	COG1846	Transcriptional regulator
GPY28_RS17725	COG2315	Protein conserved in bacteria
GPY28_RS17765	COG3063	Type IV pilus biogenesis stability protein PilW
GPY28_RS17770	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GPY28_RS17785	COG1560	Kdo2-lipid A biosynthetic process
GPY28_RS17790	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GPY28_RS17795	COG1280	lysine exporter protein (LysE YggA)
GPY28_RS17805	COG1115	amino acid carrier protein
GPY28_RS17830	COG1368	sulfuric ester hydrolase activity
GPY28_RS17835	COG2113	Glycine betaine
GPY28_RS17840	COG4176	ABC-type proline glycine betaine transport system permease component
GPY28_RS17860	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPY28_RS17865	COG0456	acetyltransferase
GPY28_RS17870	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GPY28_RS17875	COG0662	Cupin 2, conserved barrel domain protein
GPY28_RS17880	COG0527	aspartate kinase activity
GPY28_RS17885	COG3119	arylsulfatase activity
GPY28_RS17900	COG0641	radical SAM
GPY28_RS17915	COG3119	arylsulfatase activity
GPY28_RS17940	COG1538	Outer membrane efflux protein
GPY28_RS17955	COG1349	DNA-binding transcription factor activity
GPY28_RS17960	COG0673	inositol 2-dehydrogenase activity
GPY28_RS17965	COG4702	Belongs to the UPF0303 family
GPY28_RS17970	COG3706	GGDEF domain
GPY28_RS17970	COG0745	RESPONSE REGULATOR receiver
GPY28_RS17990	COG0471	metal ion transport
GPY28_RS18005	COG3300	MHYT domain
GPY28_RS18005	COG5001	Diguanylate cyclase
GPY28_RS18020	COG1328	CTP reductase activity
GPY28_RS18025	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GPY28_RS18035	COG0861	Integral membrane protein TerC family
GPY28_RS18045	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GPY28_RS18055	COG0814	amino acid
GPY28_RS18070	COG1120	ATPase activity
GPY28_RS18075	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GPY28_RS18095	COG1132	(ABC) transporter
GPY28_RS18100	COG1132	(ABC) transporter
GPY28_RS18115	COG0583	DNA-binding transcription factor activity
GPY28_RS18120	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
GPY28_RS18140	COG0443	Heat shock 70 kDa protein
GPY28_RS18145	COG0443	Heat shock 70 kDa protein
GPY28_RS18190	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GPY28_RS18195	COG1643	Atp-dependent helicase
GPY28_RS18210	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPY28_RS18220	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GPY28_RS18225	COG1215	transferase activity, transferring glycosyl groups
GPY28_RS18230	COG0438	transferase activity, transferring glycosyl groups
GPY28_RS18260	COG0438	transferase activity, transferring glycosyl groups
GPY28_RS18265	COG0297	glycogen (starch) synthase activity
GPY28_RS18270	COG2204	response regulator
GPY28_RS18300	COG1793	dna ligase
GPY28_RS18310	COG0534	Mate efflux family protein
GPY28_RS18315	COG0307	riboflavin synthase, alpha
GPY28_RS18335	COG3706	GGDEF domain
GPY28_RS18345	COG0791	NLP P60 protein
GPY28_RS18380	COG1940	carbohydrate kinase activity
GPY28_RS18390	COG0303	'Molybdopterin
GPY28_RS18395	COG0746	molybdenum cofactor guanylyltransferase activity
GPY28_RS18400	COG3842	ATPase activity
GPY28_RS18415	COG2204	response regulator
GPY28_RS18420	COG4191	Histidine kinase
GPY28_RS18430	COG0488	(ABC) transporter
GPY28_RS18435	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GPY28_RS18455	COG3381	protein complex oligomerization
GPY28_RS18465	COG3383	formate dehydrogenase (NAD+) activity
GPY28_RS18465	COG0243	molybdopterin cofactor binding
GPY28_RS18470	COG0437	4 iron, 4 sulfur cluster binding
GPY28_RS18545	COG4282	regulation of fungal-type cell wall biogenesis
GPY28_RS18585	COG0004	ammonium transporteR
GPY28_RS18590	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GPY28_RS18595	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY28_RS18600	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY28_RS18605	COG1177	transmembrane transport
GPY28_RS18610	COG1176	ABC-type spermidine putrescine transport system, permease component I
GPY28_RS18615	COG3842	ATPase activity
GPY28_RS18640	COG0589	response to stress
GPY28_RS18645	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY28_RS18660	COG2217	Heavy metal translocating P-type atpase
GPY28_RS18670	COG2010	Cytochrome c
GPY28_RS18685	COG3278	Belongs to the heme-copper respiratory oxidase family
GPY28_RS18700	COG0784	Response regulator, receiver
GPY28_RS18700	COG2205	protein histidine kinase activity
GPY28_RS18855	COG3120	sequence-specific DNA binding
GPY28_RS18860	COG1067	ATP-dependent peptidase activity
GPY28_RS18865	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPY28_RS18880	COG0488	(ABC) transporter
GPY28_RS18890	COG0116	Belongs to the methyltransferase superfamily
GPY28_RS18890	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GPY28_RS18900	COG0167	dihydroorotate dehydrogenase activity
GPY28_RS18905	COG2902	Dehydrogenase
GPY28_RS18915	COG0308	aminopeptidase N
GPY28_RS18930	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
GPY28_RS18935	COG1956	GAF domain-containing protein
GPY28_RS18940	COG1132	(ABC) transporter
GPY28_RS18945	COG2995	paraquat-inducible protein a
GPY28_RS18950	COG3008	intermembrane lipid transfer
GPY28_RS18975	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY28_RS18980	COG1666	GTP binding
GPY28_RS18990	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY28_RS18995	COG4597	amino acid ABC transporter
GPY28_RS19000	COG0765	amino acid transport
GPY28_RS19005	COG1126	abc transporter atp-binding protein
GPY28_RS19010	COG0670	Belongs to the BI1 family
GPY28_RS19020	COG2920	part of a sulfur-relay system
GPY28_RS19025	COG1254	Belongs to the acylphosphatase family
GPY28_RS19050	COG2885	chlorophyll binding
GPY28_RS19075	COG2203	Gaf domain
GPY28_RS19075	COG2199	diguanylate cyclase activity
GPY28_RS19080	COG1414	Transcriptional regulator
GPY28_RS19090	COG0656	L-ascorbic acid biosynthetic process
GPY28_RS19095	COG0583	DNA-binding transcription factor activity
GPY28_RS19105	COG0583	DNA-binding transcription factor activity
GPY28_RS19110	COG2814	Major facilitator Superfamily
GPY28_RS19130	COG1335	isochorismatase
GPY28_RS19135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY28_RS19150	COG1410	methionine synthase
GPY28_RS19150	COG0646	methionine synthase
GPY28_RS19155	COG1126	abc transporter atp-binding protein
GPY28_RS19160	COG0765	amino acid transport
GPY28_RS19165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY28_RS19180	COG0583	DNA-binding transcription factor activity
GPY28_RS19195	COG0583	DNA-binding transcription factor activity
GPY28_RS19200	COG0583	DNA-binding transcription factor activity
GPY28_RS19215	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GPY28_RS19220	COG0602	queuosine metabolic process
GPY28_RS19225	COG0561	phosphatase activity
GPY28_RS19250	COG2828	Protein conserved in bacteria
GPY28_RS19260	COG0372	Belongs to the citrate synthase family
GPY28_RS19265	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GPY28_RS19300	COG0730	response to heat
GPY28_RS19320	COG0457	Tetratricopeptide repeat
GPY28_RS19385	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GPY28_RS19390	COG4790	Type iii secretion
GPY28_RS19395	COG4794	Type iii secretion
GPY28_RS19400	COG4791	protein targeting
GPY28_RS19405	COG4792	protein secretion
GPY28_RS19410	COG2207	Transcriptional regulator
GPY28_RS19440	COG3177	Filamentation induced by cAMP protein fic
GPY28_RS19460	COG4669	(LipO)protein
GPY28_RS19530	COG1012	belongs to the aldehyde dehydrogenase family
GPY28_RS19535	COG3284	Transcriptional regulator
GPY28_RS19560	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GPY28_RS19565	COG0363	glucosamine-6-phosphate deaminase activity
GPY28_RS19570	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GPY28_RS19575	COG2207	Transcriptional regulator
GPY28_RS19585	COG4565	transcriptional regulatory protein
GPY28_RS19590	COG3290	protein histidine kinase activity
GPY28_RS19605	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY28_RS19635	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
GPY28_RS19645	COG2985	domain, Protein
GPY28_RS19670	COG2272	Belongs to the type-B carboxylesterase lipase family
GPY28_RS19675	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GPY28_RS19680	COG0729	surface antigen
GPY28_RS19690	COG1280	lysine exporter protein (LysE YggA)
GPY28_RS19695	COG1280	lysine exporter protein (LysE YggA)
GPY28_RS19700	COG5507	3-demethylubiquinone-9 3-methyltransferase
GPY28_RS19720	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GPY28_RS19730	COG0110	maltose O-acetyltransferase activity
GPY28_RS19950	COG1335	isochorismatase
GPY28_RS20115	COG2732	(Barnase) inhibitor
GPY28_RS20135	COG1942	4-Oxalocrotonate Tautomerase
GPY28_RS20155	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY28_RS20165	COG3768	UPF0283 membrane protein
GPY28_RS20170	COG3106	COG3106 Predicted ATPase
GPY28_RS20190	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GPY28_RS20195	COG2205	protein histidine kinase activity
GPY28_RS20195	COG0784	Response regulator, receiver
GPY28_RS20205	COG0494	nUDIX hydrolase
GPY28_RS20210	COG0814	amino acid
GPY28_RS20215	COG1760	l-serine dehydratase
GPY28_RS20220	COG2200	EAL domain
GPY28_RS20230	COG0720	synthase
GPY28_RS20235	COG0840	transmembrane signaling receptor activity
GPY28_RS20240	COG0017	Asparaginyl-tRNA synthetase
GPY28_RS20250	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY28_RS20265	COG1448	Aminotransferase
GPY28_RS20285	COG0840	transmembrane signaling receptor activity
GPY28_RS20290	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPY28_RS20320	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GPY28_RS20335	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPY28_RS20340	COG3108	Peptidase M15
GPY28_RS20345	COG2989	Protein conserved in bacteria
GPY28_RS20370	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GPY28_RS20380	COG4235	cytochrome complex assembly
GPY28_RS20380	COG3088	subunit of a heme lyase
GPY28_RS20390	COG1138	Cytochrome C-type biogenesis protein
GPY28_RS20395	COG3301	Polysulphide reductase, NrfD
GPY28_RS20400	COG0437	4 iron, 4 sulfur cluster binding
GPY28_RS20410	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
GPY28_RS20430	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPY28_RS20435	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GPY28_RS20440	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GPY28_RS20465	COG0019	diaminopimelate decarboxylase activity
GPY28_RS20505	COG0322	excinuclease ABC activity
GPY28_RS20510	COG2197	response regulator
GPY28_RS20515	COG0417	DNA replication proofreading
GPY28_RS20535	COG1187	pseudouridine synthase activity
GPY28_RS20545	COG0009	L-threonylcarbamoyladenylate synthase
GPY28_RS20550	COG0613	PHP domain protein
GPY28_RS20560	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GPY28_RS20565	COG0512	Glutamine amidotransferase of anthranilate synthase
GPY28_RS20575	COG0135	phosphoribosylanthranilate isomerase activity
GPY28_RS20575	COG0134	indole-3-glycerol-phosphate synthase activity
GPY28_RS20585	COG0159	tryptophan synthase activity
GPY28_RS20590	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY28_RS20595	COG0318	PFAM AMP-dependent synthetase and ligase
GPY28_RS20600	COG1301	dicarboxylic acid transport
GPY28_RS20620	COG2917	probably involved in intracellular septation
GPY28_RS20625	COG1607	acyl-coa hydrolase
GPY28_RS20630	COG2350	Protein conserved in bacteria
GPY28_RS20640	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GPY28_RS20645	COG0583	DNA-binding transcription factor activity
GPY28_RS20660	COG5001	Diguanylate cyclase
GPY28_RS20665	COG1032	radical SAM domain protein
GPY28_RS20690	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GPY28_RS20695	COG0463	Glycosyl transferase, family 2
GPY28_RS20700	COG0745	RESPONSE REGULATOR receiver
GPY28_RS20705	COG5002	protein histidine kinase activity
GPY28_RS20705	COG3850	Histidine kinase
GPY28_RS20740	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GPY28_RS20760	COG0577	efflux transmembrane transporter activity
GPY28_RS20760	COG1136	(ABC) transporter
GPY28_RS20770	COG0577	efflux transmembrane transporter activity
GPY28_RS20770	COG1136	(ABC) transporter
GPY28_RS20780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY28_RS20795	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPY28_RS20805	COG3118	belongs to the thioredoxin family
GPY28_RS20810	COG4232	protein-disulfide reductase activity
GPY28_RS20845	COG2863	cytochrome
GPY28_RS20850	COG3258	Cytochrome c
GPY28_RS20855	COG2995	paraquat-inducible protein a
GPY28_RS20860	COG3008	intermembrane lipid transfer
GPY28_RS20860	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GPY28_RS20880	COG4166	transmembrane transport
GPY28_RS20890	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
GPY28_RS20895	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
GPY28_RS20905	COG0539	negative regulation of cytoplasmic translation
GPY28_RS20910	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GPY28_RS20915	COG0616	signal peptide processing
GPY28_RS20920	COG1028	Short-chain dehydrogenase reductase Sdr
GPY28_RS20935	COG0587	DNA-directed DNA polymerase activity
GPY28_RS20940	COG0784	Response regulator, receiver
GPY28_RS20940	COG0835	chemotaxis
GPY28_RS20945	COG1940	carbohydrate kinase activity
GPY28_RS20950	COG0469	pyruvate kinase activity
GPY28_RS20955	COG4667	esterase of the alpha-beta hydrolase superfamily
GPY28_RS20970	COG0733	neurotransmitter:sodium symporter activity
GPY28_RS20985	COG1263	PTS System
GPY28_RS20985	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY28_RS20990	COG0084	hydrolase, TatD family'
GPY28_RS20995	COG0470	DNA polymerase III
GPY28_RS21000	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GPY28_RS21005	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GPY28_RS21035	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GPY28_RS21040	COG0416	fatty acid biosynthetic process
GPY28_RS21050	COG1399	metal-binding, possibly nucleic acid-binding protein
GPY28_RS21055	COG0424	maF-like protein
GPY28_RS21060	COG0564	pseudouridine synthase activity
GPY28_RS21065	COG1530	ribonuclease E activity
GPY28_RS21070	COG0659	secondary active sulfate transmembrane transporter activity
GPY28_RS21075	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GPY28_RS21080	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
GPY28_RS21090	COG0572	uridine kinase
GPY28_RS21100	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY28_RS21100	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY28_RS21125	COG2186	Transcriptional regulator
GPY28_RS21130	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GPY28_RS21135	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GPY28_RS21140	COG3012	SEC-C Motif Domain Protein
GPY28_RS21140	COG3318	Belongs to the UPF0149 family
GPY28_RS21145	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPY28_RS21150	COG3706	GGDEF domain
GPY28_RS21155	COG0366	Alpha amylase catalytic
GPY28_RS21160	COG1122	ATPase activity
GPY28_RS21165	COG4120	Belongs to the binding-protein-dependent transport system permease family
GPY28_RS21175	COG3092	negative regulation of chromosome organization
GPY28_RS21180	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GPY28_RS21185	COG0857	belongs to the CobB CobQ family
GPY28_RS21185	COG0280	phosphate acetyltransferase
GPY28_RS21195	COG0435	Glutathione S-transferase
GPY28_RS21205	COG0444	Belongs to the ABC transporter superfamily
GPY28_RS21210	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY28_RS21215	COG0601	transmembrane transport
GPY28_RS21225	COG0314	molybdopterin synthase activity
GPY28_RS21230	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GPY28_RS21235	COG0315	cyclic pyranopterin monophosphate synthase activity
GPY28_RS21240	COG0521	Mo-molybdopterin cofactor biosynthetic process
GPY28_RS21245	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GPY28_RS21250	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GPY28_RS21255	COG2198	Histidine kinase
GPY28_RS21260	COG2204	response regulator
GPY28_RS21265	COG0556	nucleotide-excision repair
GPY28_RS21275	COG1882	Formate acetyltransferase
GPY28_RS21280	COG4657	Part of a membrane complex involved in electron transport
GPY28_RS21285	COG2878	Part of a membrane complex involved in electron transport
GPY28_RS21290	COG4656	Part of a membrane complex involved in electron transport
GPY28_RS21295	COG4658	electron transport chain
GPY28_RS21300	COG4659	FMN binding
GPY28_RS21305	COG4660	Part of a membrane complex involved in electron transport
GPY28_RS21310	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GPY28_RS21315	COG0346	lactoylglutathione lyase activity
GPY28_RS21325	COG2885	chlorophyll binding
GPY28_RS21335	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GPY28_RS21340	COG2056	Na+-H+ antiporter family
GPY28_RS21425	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GPY28_RS21475	COG4695	Portal protein
GPY28_RS21550	COG4974	Belongs to the 'phage' integrase family
GPY28_RS21565	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GPY28_RS21585	COG1454	alcohol dehydrogenase
GPY28_RS21585	COG1012	belongs to the aldehyde dehydrogenase family
GPY28_RS21590	COG2095	MarC family integral membrane protein
GPY28_RS21595	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY28_RS21600	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GPY28_RS21605	COG1757	Na H antiporter
GPY28_RS21620	COG3081	Nucleoid-associated protein
GPY28_RS21625	COG3082	Protein of unknown function (DUF1414)
GPY28_RS21630	COG3083	sulfuric ester hydrolase activity
GPY28_RS21640	COG0123	including yeast histone deacetylase and acetoin utilization protein
GPY28_RS21655	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GPY28_RS21660	COG0778	Nitroreductase
GPY28_RS21670	COG0446	pyridine nucleotide-disulphide oxidoreductase
GPY28_RS21670	COG1902	pentaerythritol trinitrate reductase activity
GPY28_RS21675	COG0616	signal peptide processing
GPY28_RS21680	COG0252	asparaginase activity
GPY28_RS21685	COG3139	Protein of unknown function (DUF1315)
GPY28_RS21695	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY28_RS21700	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPY28_RS21715	COG2226	methyltransferase
GPY28_RS21735	COG1785	Belongs to the alkaline phosphatase family
GPY28_RS21745	COG0346	lactoylglutathione lyase activity
GPY28_RS21750	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
GPY28_RS21755	COG0668	transmembrane transport
GPY28_RS21815	COG2261	transglycosylase associated protein
GPY28_RS21825	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GPY28_RS21830	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GPY28_RS21835	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GPY28_RS21845	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GPY28_RS21850	COG2832	Protein of unknown function (DUF454)
GPY28_RS21860	COG0745	RESPONSE REGULATOR receiver
GPY28_RS21865	COG0583	DNA-binding transcription factor activity
GPY28_RS21870	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GPY28_RS21875	COG1286	toxin biosynthetic process
GPY28_RS21880	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
GPY28_RS21885	COG0285	dihydrofolate synthase activity
GPY28_RS21890	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GPY28_RS21895	COG0101	tRNA pseudouridine synthase activity
GPY28_RS21905	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GPY28_RS21910	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPY28_RS21915	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPY28_RS21920	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPY28_RS21920	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GPY28_RS21925	COG0431	NADPH-dependent FMN reductase
GPY28_RS21935	COG3101	peptidyl-lysine hydroxylation
GPY28_RS21945	COG2860	membrane
GPY28_RS21950	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GPY28_RS21955	COG2890	protein-(glutamine-N5) methyltransferase activity
GPY28_RS21960	COG2840	Smr protein MutS2
GPY28_RS21965	COG2062	phosphohistidine phosphatase, SixA
GPY28_RS21980	COG1250	3-hydroxyacyl-CoA dehydrogenase
GPY28_RS21980	COG1024	Enoyl-CoA hydratase
GPY28_RS21985	COG0183	Belongs to the thiolase family
GPY28_RS22005	COG2067	long-chain fatty acid transport protein
GPY28_RS22015	COG3088	subunit of a heme lyase
GPY28_RS22015	COG4235	cytochrome complex assembly
GPY28_RS22025	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GPY28_RS22030	COG1138	Cytochrome C-type biogenesis protein
GPY28_RS22035	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
GPY28_RS22040	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPY28_RS22045	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPY28_RS22050	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPY28_RS22055	COG4133	protoheme IX ABC transporter activity
GPY28_RS22065	COG0835	chemotaxis
GPY28_RS22075	COG1192	Involved in chromosome partitioning
GPY28_RS22080	COG2201	protein-glutamate methylesterase activity
GPY28_RS22085	COG0643	Histidine kinase
GPY28_RS22085	COG2198	Histidine kinase
GPY28_RS22090	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
GPY28_RS22105	COG0455	bacterial-type flagellum organization
GPY28_RS22125	COG1684	flagellar biosynthetic protein fliR
GPY28_RS22130	COG1987	bacterial-type flagellum assembly
GPY28_RS22185	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GPY28_RS22195	COG1677	Flagellar hook-basal body complex protein FliE
GPY28_RS22200	COG2204	response regulator
GPY28_RS22205	COG4191	Histidine kinase
GPY28_RS22210	COG2204	response regulator
GPY28_RS22215	COG1516	flagellar protein fliS
GPY28_RS22225	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GPY28_RS22230	COG1334	flagellar protein FlaG
GPY28_RS22235	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY28_RS22240	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY28_RS22250	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY28_RS22255	COG2837	iron assimilation
GPY28_RS22280	COG1393	Belongs to the ArsC family
GPY28_RS22285	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPY28_RS22305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GPY28_RS22315	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GPY28_RS22330	COG4783	chaperone-mediated protein folding
GPY28_RS22335	COG1393	Belongs to the ArsC family
GPY28_RS22355	COG2233	PERMEase
GPY28_RS22360	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GPY28_RS22365	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GPY28_RS22370	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GPY28_RS22375	COG0121	glutamine amidotransferase
GPY28_RS22380	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GPY28_RS22415	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GPY28_RS22420	COG0328	RNA-DNA hybrid ribonuclease activity
GPY28_RS22425	COG2226	methyltransferase
GPY28_RS22430	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPY28_RS22435	COG1388	LysM domain
GPY28_RS22435	COG0741	lytic transglycosylase activity
GPY28_RS22445	COG3021	interspecies interaction between organisms
GPY28_RS22450	COG0347	Belongs to the P(II) protein family
GPY28_RS22465	COG0825	malonyl-CoA metabolic process
GPY28_RS22470	COG0587	DNA-directed DNA polymerase activity
GPY28_RS22480	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY28_RS22485	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY28_RS22495	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY28_RS22500	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
GPY28_RS22510	COG0750	zinc metalloprotease
GPY28_RS22515	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GPY28_RS22520	COG0575	Belongs to the CDS family
GPY28_RS22525	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GPY28_RS22530	COG0233	cytoplasmic translational termination
GPY28_RS22535	COG0528	UMP kinase activity
GPY28_RS22540	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GPY28_RS22545	COG0052	Belongs to the universal ribosomal protein uS2 family
GPY28_RS22550	COG0024	Methionine aminopeptidase
GPY28_RS22555	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GPY28_RS22565	COG0564	pseudouridine synthase activity
GPY28_RS22570	COG3098	single-species biofilm formation
GPY28_RS22605	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GPY28_RS22630	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPY28_RS22640	COG0254	rRNA binding
GPY28_RS22645	COG1720	tRNA m6t6A37 methyltransferase activity
GPY28_RS22650	COG0442	prolyl-tRNA aminoacylation
GPY28_RS22670	COG0733	neurotransmitter:sodium symporter activity
GPY28_RS22690	COG0514	ATP-dependent DNA helicase (RecQ)
GPY28_RS22695	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GPY28_RS22705	COG0745	RESPONSE REGULATOR receiver
GPY28_RS22705	COG3706	GGDEF domain
GPY28_RS22715	COG1477	protein flavinylation
GPY28_RS22720	COG2871	sodium ion transport
GPY28_RS22725	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY28_RS22730	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY28_RS22735	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY28_RS22740	COG1805	sodium ion transport
GPY28_RS22745	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY28_RS22750	COG0271	Belongs to the BolA IbaG family
GPY28_RS22755	COG2813	Specifically methylates the guanine in position
GPY28_RS22760	COG3056	Lipoprotein
GPY28_RS22780	COG1595	DNA-templated transcription, initiation
GPY28_RS22800	COG3248	Nucleoside-binding outer membrane protein
GPY28_RS22805	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GPY28_RS22810	COG0693	protein deglycase activity
GPY28_RS22815	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GPY28_RS22820	COG3706	GGDEF domain
GPY28_RS22825	COG2166	iron-sulfur cluster assembly
GPY28_RS22830	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GPY28_RS22835	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
GPY28_RS22845	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GPY28_RS22845	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GPY28_RS22855	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GPY28_RS22860	COG1074	ATP-dependent DNA helicase activity
GPY28_RS22865	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GPY28_RS22885	COG3141	response to X-ray
GPY28_RS22900	COG2171	N-acyltransferase activity
GPY28_RS22905	COG0584	glycerophosphoryl diester phosphodiesterase
GPY28_RS22910	COG2271	Major facilitator Superfamily
GPY28_RS22920	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GPY28_RS22925	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GPY28_RS22930	COG1349	DNA-binding transcription factor activity
GPY28_RS22935	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GPY28_RS22940	COG0598	Magnesium transport protein CorA
GPY28_RS22960	COG1609	Transcriptional regulator
GPY28_RS22965	COG0583	DNA-binding transcription factor activity
GPY28_RS23005	COG1022	Amp-dependent synthetase and ligase
GPY28_RS23015	COG0583	DNA-binding transcription factor activity
GPY28_RS23020	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPY28_RS23025	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GPY28_RS23035	COG0560	Phosphoserine phosphatase
GPY28_RS23045	COG0813	purine-nucleoside phosphorylase activity
GPY28_RS23050	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GPY28_RS23055	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GPY28_RS23060	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GPY28_RS23065	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPY28_RS23070	COG0084	hydrolase, TatD family'
GPY28_RS23100	COG3153	acetyltransferase
GPY28_RS23125	COG0534	Mate efflux family protein
GPY28_RS23140	COG1185	polyribonucleotide nucleotidyltransferase activity
GPY28_RS23145	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GPY28_RS23150	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GPY28_RS23155	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GPY28_RS23160	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GPY28_RS23165	COG0195	Participates in both transcription termination and antitermination
GPY28_RS23170	COG0779	Required for maturation of 30S ribosomal subunits
GPY28_RS23185	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GPY28_RS23195	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPY28_RS23200	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GPY28_RS23205	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GPY28_RS23210	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GPY28_RS23215	COG1534	Rna-binding protein
GPY28_RS23220	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY28_RS23225	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPY28_RS23230	COG2027	D-alanyl-D-alanine carboxypeptidase
GPY28_RS23240	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GPY28_RS23245	COG0739	heme binding
GPY28_RS23270	COG0628	permease
GPY28_RS23285	COG0747	negative chemotaxis
GPY28_RS23300	COG0444	Belongs to the ABC transporter superfamily
GPY28_RS23305	COG4608	Belongs to the ABC transporter superfamily
GPY28_RS23315	COG2971	BadF BadG BcrA BcrD
GPY28_RS23330	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPY28_RS23335	COG3842	ATPase activity
GPY28_RS23345	COG1840	ABC-type Fe3 transport system, periplasmic component
GPY28_RS23350	COG0004	ammonium transporteR
GPY28_RS23360	COG3112	Uncharacterised protein family (UPF0231)
GPY28_RS23365	COG1049	propionate catabolic process, 2-methylcitrate cycle
GPY28_RS23370	COG1752	Esterase of the alpha-beta hydrolase superfamily
GPY28_RS23375	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GPY28_RS23380	COG1643	Atp-dependent helicase
GPY28_RS23385	COG1489	DNA binding
GPY28_RS23390	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GPY28_RS23395	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPY28_RS23405	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GPY28_RS23410	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GPY28_RS23415	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GPY28_RS23420	COG1560	Kdo2-lipid A biosynthetic process
GPY28_RS23425	COG0842	Transport permease protein
GPY28_RS23430	COG1131	(ABC) transporter
GPY28_RS23435	COG0659	secondary active sulfate transmembrane transporter activity
GPY28_RS23440	COG0288	reversible hydration of carbon dioxide
GPY28_RS23455	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY28_RS23460	COG0508	dehydrogenase complex catalyzes the overall conversion of
GPY28_RS23465	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GPY28_RS23470	COG2186	Transcriptional regulator
GPY28_RS23480	COG0157	Belongs to the NadC ModD family
GPY28_RS23490	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY28_RS23495	COG1459	type II secretion system
GPY28_RS23505	COG0237	dephospho-CoA kinase activity
GPY28_RS23510	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
GPY28_RS23515	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GPY28_RS23530	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GPY28_RS23535	COG0228	four-way junction DNA binding
GPY28_RS23540	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GPY28_RS23545	COG4137	Cytochrome C assembly protein
GPY28_RS23550	COG4536	flavin adenine dinucleotide binding
GPY28_RS23555	COG1854	S-ribosylhomocysteine lyase activity
GPY28_RS23565	COG2918	glutathione biosynthetic process
GPY28_RS23570	COG0612	Peptidase, M16
GPY28_RS23575	COG1238	metal cluster binding
GPY28_RS23585	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GPY28_RS23590	COG5016	pyruvate
GPY28_RS23590	COG0511	ligase activity, forming carbon-carbon bonds
GPY28_RS23655	COG0527	aspartate kinase activity
GPY28_RS23660	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GPY28_RS23665	COG2137	regulation of response to DNA damage stimulus
GPY28_RS23675	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GPY28_RS23680	COG1546	Belongs to the CinA family
GPY28_RS23685	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GPY28_RS23690	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPY28_RS23700	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GPY28_RS23705	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GPY28_RS23715	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GPY28_RS23720	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GPY28_RS23725	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GPY28_RS23730	COG0148	phosphopyruvate hydratase activity
GPY28_RS23735	COG0504	CTP synthase activity
GPY28_RS23740	COG3956	TIGRFAM MazG family protein
GPY28_RS23745	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GPY28_RS23755	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPY28_RS23765	COG0736	holo-[acyl-carrier-protein] synthase activity
GPY28_RS23770	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GPY28_RS23775	COG1381	Involved in DNA repair and RecF pathway recombination
GPY28_RS23780	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GPY28_RS23790	COG0681	Belongs to the peptidase S26 family
GPY28_RS23795	COG0481	GTPase activity
GPY28_RS23800	COG3086	response to oxidative stress
GPY28_RS23815	COG1595	DNA-templated transcription, initiation
GPY28_RS23825	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GPY28_RS23835	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GPY28_RS23855	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPY28_RS23860	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPY28_RS23865	COG3079	Belongs to the UPF0149 family
GPY28_RS23875	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
GPY28_RS23885	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GPY28_RS23890	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GPY28_RS23895	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPY28_RS23905	COG0583	DNA-binding transcription factor activity
GPY28_RS23920	COG0668	transmembrane transport
GPY28_RS23925	COG0191	fructose-bisphosphate aldolase activity
GPY28_RS23935	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPY28_RS23940	COG4771	TonB-dependent receptor
GPY28_RS23945	COG0583	DNA-binding transcription factor activity
GPY28_RS23950	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GPY28_RS23960	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GPY28_RS23975	COG2356	endonuclease I
GPY28_RS23980	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GPY28_RS23985	COG0189	ligase activity
GPY28_RS23990	COG1678	Uncharacterized ACR, COG1678
GPY28_RS23995	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GPY28_RS24010	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GPY28_RS24015	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GPY28_RS24020	COG0762	integral membrane protein
GPY28_RS24025	COG1872	DUF167
GPY28_RS24035	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GPY28_RS24040	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GPY28_RS24045	COG2066	Belongs to the glutaminase family
GPY28_RS24055	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GPY28_RS24065	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
GPY28_RS24110	COG0840	transmembrane signaling receptor activity
GPY28_RS24185	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GPY28_RS24195	COG3394	polysaccharide catabolic process
GPY28_RS24200	COG1486	melibiose metabolic process
GPY28_RS24205	COG1447	Phosphotransferase system cellobiose-specific component IIA
GPY28_RS24210	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GPY28_RS24220	COG0726	polysaccharide deacetylase
GPY28_RS24280	COG1028	Short-chain dehydrogenase reductase Sdr
GPY28_RS24285	COG4325	translation initiation factor activity
GPY28_RS24295	COG0795	lipopolysaccharide-transporting ATPase activity
GPY28_RS24300	COG0795	lipopolysaccharide-transporting ATPase activity
GPY28_RS24305	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GPY28_RS24310	COG2927	DNA polymerase III (CHI subunit)
GPY28_RS24315	COG0525	valine-tRNA ligase activity
GPY28_RS24325	COG0456	acetyltransferase
GPY28_RS24355	COG0540	Belongs to the ATCase OTCase family
GPY28_RS24360	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
GPY28_RS24365	COG0251	oxidation-reduction process
GPY28_RS24370	COG0204	Acyl-transferase
GPY28_RS24375	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GPY28_RS24380	COG5007	Belongs to the BolA IbaG family
GPY28_RS24390	COG2854	intermembrane phospholipid transfer
GPY28_RS24395	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GPY28_RS24400	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GPY28_RS24405	COG1127	ABC transporter
GPY28_RS24415	COG0517	IMP dehydrogenase activity
GPY28_RS24415	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GPY28_RS24425	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GPY28_RS24430	COG1137	ATPase activity
GPY28_RS24440	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GPY28_RS24445	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY28_RS24450	COG1660	Displays ATPase and GTPase activities
GPY28_RS24455	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY28_RS24460	COG2239	Acts as a magnesium transporter
GPY28_RS24465	COG0312	modulator of DNA gyrase
GPY28_RS24470	COG3028	Belongs to the UPF0307 family
GPY28_RS24475	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GPY28_RS24480	COG0564	pseudouridine synthase activity
GPY28_RS24490	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GPY28_RS24495	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GPY28_RS24500	COG0312	modulator of DNA gyrase
GPY28_RS24505	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GPY28_RS24510	COG3164	Protein of unknown function
GPY28_RS24515	COG1530	ribonuclease E activity
GPY28_RS24520	COG0424	maF-like protein
GPY28_RS24525	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GPY28_RS24530	COG1792	Involved in formation and maintenance of cell shape
GPY28_RS24535	COG1077	Cell shape determining protein MreB Mrl
GPY28_RS24580	COG1459	type II secretion system
GPY28_RS24585	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY28_RS24595	COG3267	Type II secretory pathway component ExeA
GPY28_RS24595	COG3409	Peptidoglycan-binding domain 1 protein
GPY28_RS24600	COG1450	Type ii and iii secretion system protein
GPY28_RS24620	COG2199	diguanylate cyclase activity
GPY28_RS24620	COG2200	EAL domain
GPY28_RS24625	COG0629	single-stranded DNA binding
GPY28_RS24640	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GPY28_RS24650	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GPY28_RS24655	COG0527	aspartate kinase activity
GPY28_RS24660	COG0646	methionine synthase
GPY28_RS24660	COG1410	methionine synthase
GPY28_RS24720	COG0175	sulfate reduction
GPY28_RS24725	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GPY28_RS24730	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GPY28_RS24750	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPY28_RS24755	COG0735	belongs to the Fur family
GPY28_RS24765	COG0166	Belongs to the GPI family
GPY28_RS24770	COG0432	Pfam Uncharacterised protein family UPF0047
GPY28_RS24775	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPY28_RS24780	COG0305	Participates in initiation and elongation during chromosome replication
GPY28_RS24800	COG2965	DNA replication, synthesis of RNA primer
GPY28_RS24805	COG0360	Binds together with S18 to 16S ribosomal RNA
GPY28_RS24810	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GPY28_RS24815	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GPY28_RS24825	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GPY28_RS24830	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GPY28_RS24860	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GPY28_RS24870	COG0678	peroxiredoxin activity
GPY28_RS24870	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPY28_RS24875	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY28_RS24885	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GPY28_RS24885	COG0165	Argininosuccinate lyase