locus-tag	class	description
EPB57_RS00070	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EPB57_RS00085	COG0277	FAD linked oxidase domain protein
EPB57_RS00090	COG0583	DNA-binding transcription factor activity
EPB57_RS00105	COG2425	protein containing a von Willebrand factor type A (vWA) domain
EPB57_RS00120	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
EPB57_RS00130	COG1288	antiporter activity
EPB57_RS00140	COG3040	lipid binding
EPB57_RS00150	COG0419	ATPase involved in DNA repair
EPB57_RS00155	COG0420	3'-5' exonuclease activity
EPB57_RS00225	COG0631	protein serine/threonine phosphatase activity
EPB57_RS00260	COG2815	serine threonine protein kinase
EPB57_RS00260	COG0515	serine threonine protein kinase
EPB57_RS00280	COG0745	RESPONSE REGULATOR receiver
EPB57_RS00310	COG2146	nitrite reductase [NAD(P)H] activity
EPB57_RS00310	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EPB57_RS00315	COG1116	anion transmembrane transporter activity
EPB57_RS00320	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EPB57_RS00325	COG1116	anion transmembrane transporter activity
EPB57_RS00325	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EPB57_RS00335	COG3707	response regulator
EPB57_RS00355	COG0243	molybdopterin cofactor binding
EPB57_RS00365	COG0814	amino acid
EPB57_RS00400	COG2770	Histidine kinase
EPB57_RS00400	COG2205	protein histidine kinase activity
EPB57_RS00430	COG2847	Copper chaperone PCu(A)C
EPB57_RS00435	COG1028	Short-chain dehydrogenase reductase Sdr
EPB57_RS00440	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
EPB57_RS00450	COG0800	Aldolase
EPB57_RS00455	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EPB57_RS00460	COG1917	Cupin 2, conserved barrel domain protein
EPB57_RS00505	COG2186	Transcriptional regulator
EPB57_RS00510	COG2186	Transcriptional regulator
EPB57_RS00515	COG0517	IMP dehydrogenase activity
EPB57_RS00520	COG2176	DNA-directed DNA polymerase activity
EPB57_RS00525	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EPB57_RS00595	COG4160	amino acid transport
EPB57_RS00600	COG4215	(ABC) transporter
EPB57_RS00605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EPB57_RS00610	COG1126	abc transporter atp-binding protein
EPB57_RS00640	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EPB57_RS00650	COG1012	belongs to the aldehyde dehydrogenase family
EPB57_RS00665	COG0446	pyridine nucleotide-disulphide oxidoreductase
EPB57_RS00665	COG1902	pentaerythritol trinitrate reductase activity
EPB57_RS00670	COG0109	protoheme IX farnesyltransferase activity
EPB57_RS00675	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
EPB57_RS00680	COG1845	cytochrome c oxidase, subunit III
EPB57_RS00685	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EPB57_RS00690	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EPB57_RS00695	COG1028	Short-chain dehydrogenase reductase Sdr
EPB57_RS00705	COG1024	Enoyl-CoA hydratase
EPB57_RS00710	COG1024	Enoyl-CoA hydratase
EPB57_RS00725	COG0183	Belongs to the thiolase family
EPB57_RS00735	COG1960	acyl-CoA dehydrogenase activity
EPB57_RS00740	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EPB57_RS00745	COG1024	Enoyl-CoA hydratase
EPB57_RS00760	COG0247	lactate metabolic process
EPB57_RS00760	COG0277	FAD linked oxidase domain protein
EPB57_RS00815	COG1279	arginine transmembrane transporter activity
EPB57_RS00835	COG1073	alpha beta
EPB57_RS00840	COG1073	alpha beta
EPB57_RS00850	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EPB57_RS00865	COG0513	Belongs to the DEAD box helicase family
EPB57_RS00870	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
EPB57_RS00910	COG2200	EAL domain
EPB57_RS00930	COG0513	Belongs to the DEAD box helicase family
EPB57_RS00935	COG0523	cobalamin synthesis protein
EPB57_RS00945	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
EPB57_RS00955	COG1278	Cold shock
EPB57_RS00965	COG0133	tryptophan synthase activity
EPB57_RS00975	COG4628	conserved protein (DUF2132)
EPB57_RS00980	COG0513	Belongs to the DEAD box helicase family
EPB57_RS00985	COG2814	Major facilitator Superfamily
EPB57_RS01000	COG0730	response to heat
EPB57_RS01025	COG0436	Aminotransferase
EPB57_RS01035	COG2186	Transcriptional regulator
EPB57_RS01050	COG3530	Putative quorum-sensing-regulated virulence factor
EPB57_RS01075	COG3186	Phenylalanine-4-hydroxylase
EPB57_RS01080	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EPB57_RS01085	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EPB57_RS01105	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
EPB57_RS01110	COG1454	alcohol dehydrogenase
EPB57_RS01115	COG2133	pyrroloquinoline quinone binding
EPB57_RS01125	COG0783	Belongs to the Dps family
EPB57_RS01130	COG0840	transmembrane signaling receptor activity
EPB57_RS01155	COG2205	protein histidine kinase activity
EPB57_RS01155	COG0784	Response regulator, receiver
EPB57_RS01160	COG1538	Outer membrane efflux protein
EPB57_RS01170	COG1132	(ABC) transporter
EPB57_RS01185	COG2199	diguanylate cyclase activity
EPB57_RS01190	COG3036	rescue of stalled ribosome
EPB57_RS01195	COG1278	Cold shock
EPB57_RS01225	COG0545	Peptidyl-prolyl cis-trans isomerase
EPB57_RS01230	COG0109	protoheme IX farnesyltransferase activity
EPB57_RS01235	COG1612	heme a metabolic process
EPB57_RS01255	COG1845	cytochrome c oxidase, subunit III
EPB57_RS01260	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
EPB57_RS01265	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EPB57_RS01270	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EPB57_RS01275	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EPB57_RS01285	COG1280	lysine exporter protein (LysE YggA)
EPB57_RS01305	COG0179	Fumarylacetoacetate (FAA) hydrolase
EPB57_RS01315	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EPB57_RS01320	COG0697	spore germination
EPB57_RS01340	COG2814	Major facilitator Superfamily
EPB57_RS01345	COG0583	DNA-binding transcription factor activity
EPB57_RS01350	COG5001	Diguanylate cyclase
EPB57_RS01355	COG0739	heme binding
EPB57_RS01380	COG3314	Sporulation integral membrane protein YlbJ
EPB57_RS01395	COG0814	amino acid
EPB57_RS01420	COG4989	oxidoreductase activity
EPB57_RS01445	COG1733	regulation of RNA biosynthetic process
EPB57_RS01460	COG0798	PFAM Bile acid sodium symporter
EPB57_RS01470	COG1881	PFAM PEBP family protein
EPB57_RS01485	COG1131	(ABC) transporter
EPB57_RS01490	COG0842	Transport permease protein
EPB57_RS01500	COG3383	formate dehydrogenase (NAD+) activity
EPB57_RS01520	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EPB57_RS01545	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EPB57_RS01555	COG2067	long-chain fatty acid transport protein
EPB57_RS01565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EPB57_RS01575	COG1505	serine-type exopeptidase activity
EPB57_RS01580	COG0488	(ABC) transporter
EPB57_RS01585	COG0589	response to stress
EPB57_RS01590	COG2249	NAD(P)H dehydrogenase (quinone) activity
EPB57_RS01610	COG0366	Alpha amylase catalytic
EPB57_RS01615	COG0789	Transcriptional regulator
EPB57_RS01620	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EPB57_RS01630	COG4934	collagen metabolic process
EPB57_RS01640	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EPB57_RS01645	COG0583	DNA-binding transcription factor activity
EPB57_RS01665	COG2610	gluconate transmembrane transporter activity
EPB57_RS01670	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EPB57_RS01675	COG3622	Belongs to the hyi family
EPB57_RS01680	COG0235	Class ii aldolase
EPB57_RS01685	COG3395	kinase activity
EPB57_RS01690	COG2084	Dehydrogenase
EPB57_RS01695	COG1349	DNA-binding transcription factor activity
EPB57_RS01705	COG0747	negative chemotaxis
EPB57_RS01710	COG4608	Belongs to the ABC transporter superfamily
EPB57_RS01715	COG0444	Belongs to the ABC transporter superfamily
EPB57_RS01725	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EPB57_RS01730	COG0835	chemotaxis
EPB57_RS01730	COG0784	Response regulator, receiver
EPB57_RS01740	COG0748	coenzyme F420 binding
EPB57_RS01745	COG3721	Heme iron utilization protein
EPB57_RS01755	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
EPB57_RS01760	COG0811	peptide transport
EPB57_RS01765	COG0848	biopolymer transport protein
EPB57_RS01775	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EPB57_RS01780	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
EPB57_RS01820	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EPB57_RS01830	COG0633	Ferredoxin
EPB57_RS01830	COG3217	Mosc domain protein beta barrel domain protein
EPB57_RS01830	COG0633	Ferredoxin
EPB57_RS01830	COG3217	Mosc domain protein beta barrel domain protein
EPB57_RS01835	COG0401	homolog of Blt101
EPB57_RS01845	COG0418	dihydroorotase activity
EPB57_RS01850	COG2354	Protein conserved in bacteria
EPB57_RS01880	COG3833	ABC-type maltose transport systems, permease component
EPB57_RS01885	COG1175	transmembrane transport
EPB57_RS01895	COG3842	ATPase activity
EPB57_RS01900	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EPB57_RS01915	COG0489	protein tyrosine kinase activity
EPB57_RS01915	COG3206	protein involved in exopolysaccharide biosynthesis
EPB57_RS01955	COG3097	Belongs to the UPF0267 family
EPB57_RS01960	COG1309	transcriptional regulator
EPB57_RS01965	COG2130	NADP-dependent
EPB57_RS01975	COG0753	catalase activity
EPB57_RS01980	COG2084	Dehydrogenase
EPB57_RS02010	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EPB57_RS02015	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
EPB57_RS02025	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EPB57_RS02030	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EPB57_RS02035	COG1012	belongs to the aldehyde dehydrogenase family
EPB57_RS02055	COG0583	DNA-binding transcription factor activity
EPB57_RS02060	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EPB57_RS02065	COG0569	domain protein
EPB57_RS02075	COG2205	protein histidine kinase activity
EPB57_RS02080	COG1132	(ABC) transporter
EPB57_RS02085	COG4774	siderophore transport
EPB57_RS02090	COG1120	ATPase activity
EPB57_RS02095	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
EPB57_RS02130	COG2197	response regulator
EPB57_RS02145	COG0714	Associated with various cellular activities
EPB57_RS02160	COG2304	oxidoreductase activity
EPB57_RS02165	COG2304	oxidoreductase activity
EPB57_RS02180	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EPB57_RS02185	COG0581	inorganic phosphate transmembrane transporter activity
EPB57_RS02190	COG0573	inorganic phosphate transmembrane transporter activity
EPB57_RS02220	COG4771	TonB-dependent receptor
EPB57_RS02225	COG1770	oligopeptidase
EPB57_RS02230	COG0513	Belongs to the DEAD box helicase family
EPB57_RS02240	COG1376	ErfK ybiS ycfS ynhG family protein
EPB57_RS02240	COG1388	LysM domain
EPB57_RS02245	COG0415	Belongs to the DNA photolyase family
EPB57_RS02250	COG0789	Transcriptional regulator
EPB57_RS02255	COG3272	Protein of unknown function (DUF1722)
EPB57_RS02265	COG0813	purine-nucleoside phosphorylase activity
EPB57_RS02290	COG1566	PFAM secretion protein HlyD family protein
EPB57_RS02295	COG4720	Psort location CytoplasmicMembrane, score
EPB57_RS02300	COG1122	ATPase activity
EPB57_RS02320	COG0348	domain, Protein
EPB57_RS02325	COG0437	4 iron, 4 sulfur cluster binding
EPB57_RS02330	COG1247	-acetyltransferase
EPB57_RS02350	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EPB57_RS02360	COG1067	ATP-dependent peptidase activity
EPB57_RS02370	COG4172	Belongs to the ABC transporter superfamily
EPB57_RS02375	COG1505	serine-type exopeptidase activity
EPB57_RS02380	COG0583	DNA-binding transcription factor activity
EPB57_RS02385	COG1620	l-lactate permease
EPB57_RS02390	COG1304	FMN binding
EPB57_RS02400	COG0668	transmembrane transport
EPB57_RS02435	COG1063	alcohol dehydrogenase
EPB57_RS02440	COG0156	8-amino-7-oxononanoate synthase activity
EPB57_RS02445	COG5001	Diguanylate cyclase
EPB57_RS02445	COG3300	MHYT domain
EPB57_RS02470	COG0745	RESPONSE REGULATOR receiver
EPB57_RS02495	COG0346	lactoylglutathione lyase activity
EPB57_RS02555	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EPB57_RS02595	COG1987	bacterial-type flagellum assembly
EPB57_RS02605	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EPB57_RS02620	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EPB57_RS02625	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
EPB57_RS02630	COG1516	flagellar protein fliS
EPB57_RS02645	COG1580	Controls the rotational direction of flagella during chemotaxis
EPB57_RS02650	COG1191	sigma factor activity
EPB57_RS02655	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EPB57_RS02660	COG1360	Flagellar Motor Protein
EPB57_RS02695	COG1882	Formate acetyltransferase
EPB57_RS02700	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EPB57_RS02705	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EPB57_RS02720	COG2205	protein histidine kinase activity
EPB57_RS02725	COG0745	RESPONSE REGULATOR receiver
EPB57_RS02735	COG0454	-acetyltransferase
EPB57_RS02745	COG2814	Major facilitator Superfamily
EPB57_RS02790	COG0628	permease
EPB57_RS02795	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
EPB57_RS02815	COG4628	conserved protein (DUF2132)
EPB57_RS02820	COG0583	DNA-binding transcription factor activity
EPB57_RS02845	COG1686	Belongs to the peptidase S11 family
EPB57_RS02855	COG1054	Belongs to the UPF0176 family
EPB57_RS02865	COG0415	Belongs to the DNA photolyase family
EPB57_RS02870	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
EPB57_RS02875	COG3397	chitin binding
EPB57_RS02880	COG4667	esterase of the alpha-beta hydrolase superfamily
EPB57_RS02885	COG2095	MarC family integral membrane protein
EPB57_RS02900	COG1596	polysaccharide export
EPB57_RS02905	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EPB57_RS02925	COG0583	DNA-binding transcription factor activity
EPB57_RS02935	COG1301	dicarboxylic acid transport
EPB57_RS02945	COG3339	Conserved Protein
EPB57_RS02950	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EPB57_RS02955	COG0700	Nucleoside recognition
EPB57_RS02975	COG0366	Alpha amylase catalytic
EPB57_RS02980	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EPB57_RS02985	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EPB57_RS02990	COG1640	4-alpha-glucanotransferase
EPB57_RS02995	COG0058	SHG alpha-glucan phosphorylase activity
EPB57_RS03000	COG2909	trisaccharide binding
EPB57_RS03015	COG1999	signal sequence binding
EPB57_RS03020	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EPB57_RS03020	COG1263	PTS System
EPB57_RS03025	COG1162	GTPase activity
EPB57_RS03030	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
EPB57_RS03035	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
EPB57_RS03055	COG2356	endonuclease I
EPB57_RS03075	COG4580	involved in the transport of maltose and maltodextrins
EPB57_RS03085	COG1760	l-serine dehydratase
EPB57_RS03125	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EPB57_RS03135	COG1609	Transcriptional regulator
EPB57_RS03140	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EPB57_RS03145	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EPB57_RS03145	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
EPB57_RS03150	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
EPB57_RS03150	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EPB57_RS03165	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EPB57_RS03170	COG1609	Transcriptional regulator
EPB57_RS03180	COG2814	Major facilitator Superfamily
EPB57_RS03195	COG0739	heme binding
EPB57_RS03205	COG0612	Peptidase, M16
EPB57_RS03210	COG0840	transmembrane signaling receptor activity
EPB57_RS03215	COG1120	ATPase activity
EPB57_RS03220	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EPB57_RS03225	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EPB57_RS03235	COG4772	TonB-dependent receptor
EPB57_RS03260	COG4264	IucA IucC family
EPB57_RS03265	COG0019	diaminopimelate decarboxylase activity
EPB57_RS03270	COG1653	transport
EPB57_RS03300	COG0826	peptidase U32
EPB57_RS03320	COG0463	Glycosyl transferase, family 2
EPB57_RS03335	COG1136	(ABC) transporter
EPB57_RS03340	COG0577	efflux transmembrane transporter activity
EPB57_RS03370	COG1764	response to oxidative stress
EPB57_RS03375	COG1846	Transcriptional regulator
EPB57_RS03385	COG3634	alkyl hydroperoxide reductase activity
EPB57_RS03435	COG2258	MOSC domain
EPB57_RS03440	COG0513	Belongs to the DEAD box helicase family
EPB57_RS03450	COG1132	(ABC) transporter
EPB57_RS03490	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EPB57_RS03515	COG0259	pyridoxamine-phosphate oxidase activity
EPB57_RS03565	COG4166	transmembrane transport
EPB57_RS03585	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EPB57_RS03590	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EPB57_RS03590	COG1263	PTS System
EPB57_RS03595	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EPB57_RS03600	COG3340	Belongs to the peptidase S51 family
EPB57_RS03620	COG1444	tRNA N-acetyltransferase activity
EPB57_RS03645	COG4608	Belongs to the ABC transporter superfamily
EPB57_RS03650	COG0444	Belongs to the ABC transporter superfamily
EPB57_RS03660	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
EPB57_RS03660	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EPB57_RS03685	COG0772	Belongs to the SEDS family
EPB57_RS03695	COG1136	(ABC) transporter
EPB57_RS03715	COG3275	phosphorelay sensor kinase activity
EPB57_RS03720	COG3279	Response regulator of the LytR AlgR family
EPB57_RS03730	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EPB57_RS03750	COG0786	glutamate:sodium symporter activity
EPB57_RS03760	COG1131	(ABC) transporter
EPB57_RS03765	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EPB57_RS03770	COG0786	glutamate:sodium symporter activity
EPB57_RS03780	COG0363	glucosamine-6-phosphate deaminase activity
EPB57_RS03800	COG1741	Belongs to the pirin family
EPB57_RS03805	COG2259	Doxx family
EPB57_RS03815	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EPB57_RS03815	COG2169	Transcriptional regulator
EPB57_RS03820	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EPB57_RS03830	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EPB57_RS03855	COG0596	Alpha beta hydrolase
EPB57_RS03870	COG3123	guanosine phosphorylase activity
EPB57_RS03885	COG0534	Mate efflux family protein
EPB57_RS03890	COG0564	pseudouridine synthase activity
EPB57_RS03905	COG0583	DNA-binding transcription factor activity
EPB57_RS03910	COG0561	phosphatase activity
EPB57_RS03920	COG2199	diguanylate cyclase activity
EPB57_RS03935	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
EPB57_RS03940	COG2162	N-hydroxyarylamine O-acetyltransferase activity
EPB57_RS03945	COG0583	DNA-binding transcription factor activity
EPB57_RS03950	COG2375	cellular response to nickel ion
EPB57_RS03980	COG1357	PFAM Pentapeptide repeats (8 copies)
EPB57_RS03985	COG3047	cAMP biosynthetic process
EPB57_RS04045	COG3835	regulator
EPB57_RS04050	COG2610	gluconate transmembrane transporter activity
EPB57_RS04055	COG1929	Belongs to the glycerate kinase type-1 family
EPB57_RS04060	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EPB57_RS04080	COG0456	acetyltransferase
EPB57_RS04095	COG1028	Short-chain dehydrogenase reductase Sdr
EPB57_RS04100	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EPB57_RS04105	COG3005	denitrification pathway
EPB57_RS04110	COG0243	molybdopterin cofactor binding
EPB57_RS04130	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EPB57_RS04135	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EPB57_RS04140	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EPB57_RS04145	COG1116	anion transmembrane transporter activity
EPB57_RS04150	COG0351	phosphomethylpyrimidine kinase
EPB57_RS04155	COG0312	modulator of DNA gyrase
EPB57_RS04160	COG0312	modulator of DNA gyrase
EPB57_RS04165	COG1901	pseudouridine methyltransferase
EPB57_RS04225	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EPB57_RS04235	COG0584	glycerophosphoryl diester phosphodiesterase
EPB57_RS04240	COG0745	RESPONSE REGULATOR receiver
EPB57_RS04260	COG0811	peptide transport
EPB57_RS04265	COG0811	peptide transport
EPB57_RS04270	COG0848	biopolymer transport protein
EPB57_RS04310	COG0803	Belongs to the bacterial solute-binding protein 9 family
EPB57_RS04315	COG1121	(ABC) transporter
EPB57_RS04320	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EPB57_RS04335	COG1770	oligopeptidase
EPB57_RS04340	COG2814	Major facilitator Superfamily
EPB57_RS04345	COG0010	Belongs to the arginase family
EPB57_RS04350	COG1166	arginine decarboxylase activity
EPB57_RS04360	COG0189	ligase activity
EPB57_RS04360	COG4067	protein conserved in archaea
EPB57_RS04365	COG0189	ligase activity
EPB57_RS04385	COG0583	DNA-binding transcription factor activity
EPB57_RS04420	COG3706	GGDEF domain
EPB57_RS04445	COG0579	oxidoreductase
EPB57_RS04450	COG3179	chitinase
EPB57_RS04470	COG1294	oxidase, subunit
EPB57_RS04475	COG1271	oxidase subunit
EPB57_RS04485	COG3033	Beta-eliminating lyase
EPB57_RS04505	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EPB57_RS04520	COG3706	GGDEF domain
EPB57_RS04535	COG3706	GGDEF domain
EPB57_RS04540	COG0415	Belongs to the DNA photolyase family
EPB57_RS04545	COG3046	protein related to deoxyribodipyrimidine photolyase
EPB57_RS04560	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EPB57_RS04560	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EPB57_RS04565	COG1765	OsmC-like protein
EPB57_RS04570	COG0110	maltose O-acetyltransferase activity
EPB57_RS04605	COG1011	Hydrolase
EPB57_RS04620	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
EPB57_RS04630	COG2067	long-chain fatty acid transport protein
EPB57_RS04635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EPB57_RS04640	COG0577	efflux transmembrane transporter activity
EPB57_RS04640	COG1136	(ABC) transporter
EPB57_RS04655	COG1309	transcriptional regulator
EPB57_RS04660	COG3240	lipase activity
EPB57_RS04680	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EPB57_RS04690	COG1840	ABC-type Fe3 transport system, periplasmic component
EPB57_RS04695	COG3842	ATPase activity
EPB57_RS04720	COG2990	Protein conserved in bacteria
EPB57_RS04730	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EPB57_RS04735	COG2866	Carboxypeptidase
EPB57_RS04745	COG0583	DNA-binding transcription factor activity
EPB57_RS04760	COG1760	l-serine dehydratase
EPB57_RS04780	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EPB57_RS04785	COG0741	lytic transglycosylase activity
EPB57_RS04805	COG1815	bacterial-type flagellum-dependent cell motility
EPB57_RS04810	COG1558	bacterial-type flagellum-dependent cell motility
EPB57_RS04825	COG4787	bacterial-type flagellum-dependent cell motility
EPB57_RS04830	COG4786	Flagellar basal body rod
EPB57_RS04835	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
EPB57_RS04840	COG1706	bacterial-type flagellum-dependent cell motility
EPB57_RS04850	COG1256	bacterial-type flagellum assembly
EPB57_RS04850	COG4786	Flagellar basal body rod
EPB57_RS04875	COG1304	FMN binding
EPB57_RS04890	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EPB57_RS04895	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EPB57_RS04900	COG0459	protein refolding
EPB57_RS04910	COG1280	lysine exporter protein (LysE YggA)
EPB57_RS04930	COG1309	transcriptional regulator
EPB57_RS04940	COG4303	Ethanolamine ammonia lyase large subunit
EPB57_RS04945	COG4302	ethanolamine ammonia-lyase activity
EPB57_RS04950	COG0531	amino acid
EPB57_RS04955	COG2070	2-Nitropropane dioxygenase
EPB57_RS04965	COG1349	DNA-binding transcription factor activity
EPB57_RS04980	COG1335	isochorismatase
EPB57_RS04990	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EPB57_RS05015	COG0583	DNA-binding transcription factor activity
EPB57_RS05030	COG3713	MltA-interacting MipA family protein
EPB57_RS05035	COG3015	lipoprotein NlpE involved in copper resistance
EPB57_RS05040	COG3448	diguanylate cyclase activity
EPB57_RS05040	COG4175	Glycine betaine
EPB57_RS05045	COG4176	ABC-type proline glycine betaine transport system permease component
EPB57_RS05050	COG1342	Belongs to the UPF0251 family
EPB57_RS05085	COG4948	Mandelate Racemase Muconate Lactonizing
EPB57_RS05095	COG0583	DNA-binding transcription factor activity
EPB57_RS05135	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EPB57_RS05185	COG3842	ATPase activity
EPB57_RS05215	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EPB57_RS05240	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EPB57_RS05245	COG2197	response regulator
EPB57_RS05260	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
EPB57_RS05265	COG0252	asparaginase activity
EPB57_RS05270	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EPB57_RS05275	COG0583	DNA-binding transcription factor activity
EPB57_RS05290	COG3122	Protein conserved in bacteria
EPB57_RS05295	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EPB57_RS05300	COG1012	belongs to the aldehyde dehydrogenase family
EPB57_RS05305	COG1522	sequence-specific DNA binding
EPB57_RS05310	COG3608	succinylglutamate desuccinylase aspartoacylase
EPB57_RS05315	COG0006	proline dipeptidase activity
EPB57_RS05320	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EPB57_RS05330	COG1028	Short-chain dehydrogenase reductase Sdr
EPB57_RS05340	COG1063	alcohol dehydrogenase
EPB57_RS05345	COG1902	pentaerythritol trinitrate reductase activity
EPB57_RS05360	COG0583	DNA-binding transcription factor activity
EPB57_RS05370	COG0513	Belongs to the DEAD box helicase family
EPB57_RS05400	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EPB57_RS05405	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EPB57_RS05405	COG2207	Transcriptional regulator
EPB57_RS05410	COG0583	DNA-binding transcription factor activity
EPB57_RS05430	COG3746	phosphate-selective porin O and P
EPB57_RS05445	COG1028	Short-chain dehydrogenase reductase Sdr
EPB57_RS05465	COG1263	PTS System
EPB57_RS05465	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EPB57_RS05470	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EPB57_RS05475	COG1621	beta-fructofuranosidase activity
EPB57_RS05480	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EPB57_RS05490	COG0625	glutathione transferase activity
EPB57_RS05495	COG1686	Belongs to the peptidase S11 family
EPB57_RS05505	COG0678	peroxiredoxin activity
EPB57_RS05505	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EPB57_RS05510	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EPB57_RS05525	COG1278	Cold shock
EPB57_RS05530	COG1741	Belongs to the pirin family
EPB57_RS05535	COG4667	esterase of the alpha-beta hydrolase superfamily
EPB57_RS05555	COG2194	sulfuric ester hydrolase activity
EPB57_RS05560	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EPB57_RS05570	COG2205	protein histidine kinase activity
EPB57_RS05575	COG0745	RESPONSE REGULATOR receiver
EPB57_RS05590	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EPB57_RS05610	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EPB57_RS05620	COG2814	Major facilitator Superfamily
EPB57_RS05635	COG1418	mRNA catabolic process
EPB57_RS05645	COG0402	S-adenosylhomocysteine deaminase activity
EPB57_RS05650	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
EPB57_RS05655	COG2239	Acts as a magnesium transporter
EPB57_RS05660	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EPB57_RS05665	COG1566	PFAM secretion protein HlyD family protein
EPB57_RS05690	COG0745	RESPONSE REGULATOR receiver
EPB57_RS05695	COG2205	protein histidine kinase activity
EPB57_RS05710	COG0531	amino acid
EPB57_RS05725	COG0583	DNA-binding transcription factor activity
EPB57_RS05745	COG0784	Response regulator, receiver
EPB57_RS05745	COG2205	protein histidine kinase activity
EPB57_RS05745	COG5002	protein histidine kinase activity
EPB57_RS05765	COG3132	Protein of unknown function, DUF480
EPB57_RS05770	COG2827	Endonuclease containing a URI domain
EPB57_RS05775	COG1879	ABC-type sugar transport system periplasmic component
EPB57_RS05785	COG1846	Transcriptional regulator
EPB57_RS05835	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EPB57_RS05840	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EPB57_RS05850	COG1280	lysine exporter protein (LysE YggA)
EPB57_RS05860	COG0183	Belongs to the thiolase family
EPB57_RS05870	COG3243	poly(R)-hydroxyalkanoic acid synthase
EPB57_RS05880	COG3005	denitrification pathway
EPB57_RS05890	COG0243	molybdopterin cofactor binding
EPB57_RS05900	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EPB57_RS05905	COG3850	Histidine kinase
EPB57_RS05910	COG2197	response regulator
EPB57_RS05925	COG2195	Cleaves the N-terminal amino acid of tripeptides
EPB57_RS05945	COG0840	transmembrane signaling receptor activity
EPB57_RS05955	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EPB57_RS05965	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EPB57_RS05970	COG2814	Major facilitator Superfamily
EPB57_RS05975	COG0840	transmembrane signaling receptor activity
EPB57_RS05980	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EPB57_RS05985	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EPB57_RS06000	COG2897	thiosulfate sulfurtransferase activity
EPB57_RS06035	COG0038	chloride channel
EPB57_RS06050	COG4989	oxidoreductase activity
EPB57_RS06065	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EPB57_RS06065	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
EPB57_RS06075	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
EPB57_RS06120	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EPB57_RS06135	COG0739	heme binding
EPB57_RS06175	COG3501	Rhs element vgr protein
EPB57_RS06200	COG0515	serine threonine protein kinase
EPB57_RS06235	COG1522	sequence-specific DNA binding
EPB57_RS06295	COG2814	Major facilitator Superfamily
EPB57_RS06305	COG0583	DNA-binding transcription factor activity
EPB57_RS06310	COG4221	oxidoreductase activity
EPB57_RS06315	COG0589	response to stress
EPB57_RS06325	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EPB57_RS06325	COG2111	Na H antiporter
EPB57_RS06330	COG1006	Multisubunit Na H antiporter MnhC subunit
EPB57_RS06335	COG0651	ATP synthesis coupled electron transport
EPB57_RS06340	COG1863	multisubunit Na H antiporter MnhE subunit
EPB57_RS06345	COG2212	antiporter activity
EPB57_RS06350	COG1320	monovalent cation:proton antiporter activity
EPB57_RS06355	COG2188	Transcriptional regulator
EPB57_RS06360	COG1486	melibiose metabolic process
EPB57_RS06365	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EPB57_RS06365	COG1263	PTS System
EPB57_RS06370	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EPB57_RS06400	COG1022	Amp-dependent synthetase and ligase
EPB57_RS06430	COG0500	methyltransferase
EPB57_RS06435	COG1028	Short-chain dehydrogenase reductase Sdr
EPB57_RS06445	COG3527	Alpha-acetolactate decarboxylase
EPB57_RS06455	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EPB57_RS06470	COG1294	oxidase, subunit
EPB57_RS06475	COG1271	oxidase subunit
EPB57_RS06480	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EPB57_RS06485	COG0110	maltose O-acetyltransferase activity
EPB57_RS06495	COG3264	Mechanosensitive ion channel
EPB57_RS06495	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
EPB57_RS06510	COG4770	biotin carboxylase activity
EPB57_RS06520	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EPB57_RS06525	COG1960	acyl-CoA dehydrogenase activity
EPB57_RS06535	COG0183	Belongs to the thiolase family
EPB57_RS06545	COG1960	acyl-CoA dehydrogenase activity
EPB57_RS06550	COG1024	Enoyl-CoA hydratase
EPB57_RS06565	COG1028	Short-chain dehydrogenase reductase Sdr
EPB57_RS06575	COG1309	transcriptional regulator
EPB57_RS06580	COG1012	belongs to the aldehyde dehydrogenase family
EPB57_RS06595	COG4176	ABC-type proline glycine betaine transport system permease component
EPB57_RS06600	COG4175	Glycine betaine
EPB57_RS06600	COG0517	IMP dehydrogenase activity
EPB57_RS06615	COG0330	HflC and HflK could
EPB57_RS06630	COG0784	Response regulator, receiver
EPB57_RS06630	COG2205	protein histidine kinase activity
EPB57_RS06640	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EPB57_RS06695	COG5001	Diguanylate cyclase
EPB57_RS06700	COG1869	D-ribose catabolic process
EPB57_RS06705	COG1129	ABC transporter
EPB57_RS06710	COG1172	Belongs to the binding-protein-dependent transport system permease family
EPB57_RS06715	COG1879	ABC-type sugar transport system periplasmic component
EPB57_RS06720	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EPB57_RS06725	COG1609	Transcriptional regulator
EPB57_RS06735	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
EPB57_RS06745	COG4607	ABC-type enterochelin transport system periplasmic component
EPB57_RS06750	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EPB57_RS06755	COG4605	iron ion homeostasis
EPB57_RS06760	COG4604	ABC transporter, ATP-binding protein
EPB57_RS06765	COG0789	Transcriptional regulator
EPB57_RS06775	COG4771	TonB-dependent receptor
EPB57_RS06775	COG1629	transport
EPB57_RS06805	COG1289	transmembrane transporter activity
EPB57_RS06810	COG0210	DNA helicase
EPB57_RS06815	COG1803	Methylglyoxal synthase
EPB57_RS06820	COG1879	ABC-type sugar transport system periplasmic component
EPB57_RS06825	COG2205	protein histidine kinase activity
EPB57_RS06825	COG2198	Histidine kinase
EPB57_RS06825	COG0784	Response regulator, receiver
EPB57_RS06840	COG0745	RESPONSE REGULATOR receiver
EPB57_RS06845	COG3119	arylsulfatase activity
EPB57_RS06855	COG3119	arylsulfatase activity
EPB57_RS06860	COG0641	radical SAM
EPB57_RS06865	COG0714	Associated with various cellular activities
EPB57_RS06900	COG0583	DNA-binding transcription factor activity
EPB57_RS06905	COG1597	lipid kinase activity
EPB57_RS06910	COG3111	PFAM Bacterial OB fold (BOF) protein
EPB57_RS06935	COG3069	C4-dicarboxylate transmembrane transporter activity
EPB57_RS06945	COG0456	acetyltransferase
EPB57_RS06945	COG1214	PFAM Peptidase M22, glycoprotease
EPB57_RS06970	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
EPB57_RS06975	COG0784	Response regulator, receiver
EPB57_RS06975	COG2205	protein histidine kinase activity
EPB57_RS06980	COG3300	MHYT domain
EPB57_RS06980	COG5001	Diguanylate cyclase
EPB57_RS06985	COG2197	response regulator
EPB57_RS06990	COG3706	GGDEF domain
EPB57_RS07000	COG2197	response regulator
EPB57_RS07010	COG0784	Response regulator, receiver
EPB57_RS07010	COG0835	chemotaxis
EPB57_RS07025	COG2962	Rard protein
EPB57_RS07045	COG2076	Multidrug Resistance protein
EPB57_RS07080	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
EPB57_RS07085	COG5642	Protein of unknown function (DUF2384)
EPB57_RS07105	COG1902	pentaerythritol trinitrate reductase activity
EPB57_RS07110	COG0346	lactoylglutathione lyase activity
EPB57_RS07130	COG2239	Acts as a magnesium transporter
EPB57_RS07165	COG0242	peptide deformylase activity
EPB57_RS07210	COG2176	DNA-directed DNA polymerase activity
EPB57_RS07240	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EPB57_RS07245	COG0697	spore germination
EPB57_RS07250	COG0583	DNA-binding transcription factor activity
EPB57_RS07255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EPB57_RS07265	COG0346	lactoylglutathione lyase activity
EPB57_RS07275	COG0509	glycine decarboxylation via glycine cleavage system
EPB57_RS07280	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EPB57_RS07290	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EPB57_RS07320	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EPB57_RS07320	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EPB57_RS07320	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
EPB57_RS07325	COG1105	Belongs to the carbohydrate kinase PfkB family
EPB57_RS07330	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EPB57_RS07330	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
EPB57_RS07335	COG1609	Transcriptional regulator
EPB57_RS07350	COG2199	diguanylate cyclase activity
EPB57_RS07350	COG2203	Gaf domain
EPB57_RS07350	COG2200	EAL domain
EPB57_RS07355	COG0765	amino acid transport
EPB57_RS07360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EPB57_RS07365	COG0765	amino acid transport
EPB57_RS07370	COG1126	abc transporter atp-binding protein
EPB57_RS07380	COG1979	alcohol dehydrogenase
EPB57_RS07385	COG2207	Transcriptional regulator
EPB57_RS07400	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EPB57_RS07405	COG2759	Belongs to the formate--tetrahydrofolate ligase family
EPB57_RS07410	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EPB57_RS07425	COG0546	phosphoglycolate phosphatase activity
EPB57_RS07430	COG0840	transmembrane signaling receptor activity
EPB57_RS07440	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
EPB57_RS07445	COG0513	Belongs to the DEAD box helicase family
EPB57_RS07465	COG3038	cytochrome b561
EPB57_RS07470	COG2353	YceI-like domain
EPB57_RS07475	COG2116	formate transmembrane transporter activity
EPB57_RS07480	COG0583	DNA-binding transcription factor activity
EPB57_RS07490	COG3593	DNA synthesis involved in DNA repair
EPB57_RS07495	COG0737	Belongs to the 5'-nucleotidase family
EPB57_RS07520	COG2267	carboxylic ester hydrolase activity
EPB57_RS07525	COG2067	long-chain fatty acid transport protein
EPB57_RS07545	COG2050	protein possibly involved in aromatic compounds catabolism
EPB57_RS07555	COG4533	DNA binding
EPB57_RS07580	COG0484	heat shock protein binding
EPB57_RS07590	COG3300	MHYT domain
EPB57_RS07590	COG5001	Diguanylate cyclase
EPB57_RS07595	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EPB57_RS07605	COG4181	ATPase activity
EPB57_RS07610	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
EPB57_RS07705	COG4974	Belongs to the 'phage' integrase family
EPB57_RS07715	COG1984	allophanate hydrolase subunit 2
EPB57_RS07720	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
EPB57_RS07725	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
EPB57_RS07730	COG3447	MASE1 domain protein
EPB57_RS07730	COG5001	Diguanylate cyclase
EPB57_RS07730	COG5002	protein histidine kinase activity
EPB57_RS07750	COG0583	DNA-binding transcription factor activity
EPB57_RS07755	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EPB57_RS07755	COG1042	CoA-binding domain protein
EPB57_RS07755	COG0045	succinate-CoA ligase (ADP-forming) activity
EPB57_RS07765	COG1181	Belongs to the D-alanine--D-alanine ligase family
EPB57_RS07775	COG0023	Translation Initiation Factor
EPB57_RS07910	COG0583	DNA-binding transcription factor activity
EPB57_RS07925	COG3140	Belongs to the UPF0181 family
EPB57_RS07950	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
EPB57_RS07955	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
EPB57_RS07975	COG5001	Diguanylate cyclase
EPB57_RS07975	COG4251	negative regulation of phosphorylation
EPB57_RS07975	COG3706	GGDEF domain
EPB57_RS07975	COG2203	Gaf domain
EPB57_RS07985	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
EPB57_RS07990	COG4149	molybdate abc transporter
EPB57_RS07995	COG0725	ABC transporter, periplasmic molybdate-binding protein
EPB57_RS08005	COG3111	PFAM Bacterial OB fold (BOF) protein
EPB57_RS08015	COG0189	ligase activity
EPB57_RS08015	COG4067	protein conserved in archaea
EPB57_RS08025	COG2207	Transcriptional regulator
EPB57_RS08030	COG0534	Mate efflux family protein
EPB57_RS08035	COG0602	queuosine metabolic process
EPB57_RS08040	COG1328	CTP reductase activity
EPB57_RS08070	COG1794	racemase activity, acting on amino acids and derivatives
EPB57_RS08075	COG0384	phenazine biosynthesis protein PhzF
EPB57_RS08090	COG0243	molybdopterin cofactor binding
EPB57_RS08100	COG0583	DNA-binding transcription factor activity
EPB57_RS08105	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EPB57_RS08115	COG2197	response regulator
EPB57_RS08120	COG3851	Histidine kinase
EPB57_RS08125	COG2271	Major facilitator Superfamily
EPB57_RS08150	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EPB57_RS08155	COG3118	belongs to the thioredoxin family
EPB57_RS08190	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EPB57_RS08210	COG2116	formate transmembrane transporter activity
EPB57_RS08220	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EPB57_RS08225	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EPB57_RS08235	COG1187	pseudouridine synthase activity
EPB57_RS08255	COG0417	DNA replication proofreading
EPB57_RS08260	COG2197	response regulator
EPB57_RS08265	COG0322	excinuclease ABC activity
EPB57_RS08305	COG0019	diaminopimelate decarboxylase activity
EPB57_RS08335	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EPB57_RS08340	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EPB57_RS08360	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
EPB57_RS08370	COG0437	4 iron, 4 sulfur cluster binding
EPB57_RS08375	COG3301	Polysulphide reductase, NrfD
EPB57_RS08380	COG1138	Cytochrome C-type biogenesis protein
EPB57_RS08390	COG4235	cytochrome complex assembly
EPB57_RS08390	COG3088	subunit of a heme lyase
EPB57_RS08400	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EPB57_RS08425	COG2989	Protein conserved in bacteria
EPB57_RS08430	COG3108	Peptidase M15
EPB57_RS08435	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EPB57_RS08450	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EPB57_RS08480	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EPB57_RS08485	COG0840	transmembrane signaling receptor activity
EPB57_RS08505	COG1448	Aminotransferase
EPB57_RS08520	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EPB57_RS08530	COG0017	Asparaginyl-tRNA synthetase
EPB57_RS08535	COG0840	transmembrane signaling receptor activity
EPB57_RS08540	COG0720	synthase
EPB57_RS08550	COG2200	EAL domain
EPB57_RS08555	COG1760	l-serine dehydratase
EPB57_RS08560	COG0814	amino acid
EPB57_RS08565	COG0494	nUDIX hydrolase
EPB57_RS08575	COG0784	Response regulator, receiver
EPB57_RS08575	COG2205	protein histidine kinase activity
EPB57_RS08580	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EPB57_RS08600	COG3106	COG3106 Predicted ATPase
EPB57_RS08605	COG3768	UPF0283 membrane protein
EPB57_RS08615	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EPB57_RS08675	COG1280	lysine exporter protein (LysE YggA)
EPB57_RS08720	COG0110	maltose O-acetyltransferase activity
EPB57_RS08730	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EPB57_RS08750	COG5507	3-demethylubiquinone-9 3-methyltransferase
EPB57_RS08755	COG1280	lysine exporter protein (LysE YggA)
EPB57_RS08760	COG1280	lysine exporter protein (LysE YggA)
EPB57_RS08770	COG0729	surface antigen
EPB57_RS08775	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EPB57_RS08805	COG2985	domain, Protein
EPB57_RS08815	COG4974	Belongs to the 'phage' integrase family
EPB57_RS08870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EPB57_RS08900	COG3196	Protein conserved in bacteria
EPB57_RS08925	COG0456	acetyltransferase
EPB57_RS08970	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EPB57_RS09025	COG0346	lactoylglutathione lyase activity
EPB57_RS09125	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
EPB57_RS09155	COG2801	Transposase and inactivated derivatives
EPB57_RS09175	COG4977	sequence-specific DNA binding
EPB57_RS09195	COG2801	Transposase and inactivated derivatives
EPB57_RS09205	COG2200	EAL domain
EPB57_RS09210	COG2264	protein methyltransferase activity
EPB57_RS09225	COG2205	protein histidine kinase activity
EPB57_RS09225	COG0784	Response regulator, receiver
EPB57_RS09240	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
EPB57_RS09255	COG0583	DNA-binding transcription factor activity
EPB57_RS09270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EPB57_RS09285	COG3290	protein histidine kinase activity
EPB57_RS09290	COG4565	transcriptional regulatory protein
EPB57_RS09300	COG2207	Transcriptional regulator
EPB57_RS09305	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EPB57_RS09310	COG0363	glucosamine-6-phosphate deaminase activity
EPB57_RS09315	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
EPB57_RS09335	COG3284	Transcriptional regulator
EPB57_RS09340	COG1012	belongs to the aldehyde dehydrogenase family
EPB57_RS09415	COG4669	(LipO)protein
EPB57_RS09435	COG3177	Filamentation induced by cAMP protein fic
EPB57_RS09465	COG2207	Transcriptional regulator
EPB57_RS09470	COG4792	protein secretion
EPB57_RS09475	COG4791	protein targeting
EPB57_RS09480	COG4794	Type iii secretion
EPB57_RS09485	COG4790	Type iii secretion
EPB57_RS09555	COG0457	Tetratricopeptide repeat
EPB57_RS09575	COG2358	TRAP transporter, solute receptor (TAXI family
EPB57_RS09580	COG0730	response to heat
EPB57_RS09615	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
EPB57_RS09620	COG0372	Belongs to the citrate synthase family
EPB57_RS09630	COG2828	Protein conserved in bacteria
EPB57_RS09655	COG0561	phosphatase activity
EPB57_RS09660	COG0602	queuosine metabolic process
EPB57_RS09665	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EPB57_RS09680	COG0583	DNA-binding transcription factor activity
EPB57_RS09685	COG0583	DNA-binding transcription factor activity
EPB57_RS09700	COG0583	DNA-binding transcription factor activity
EPB57_RS09715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EPB57_RS09720	COG0765	amino acid transport
EPB57_RS09725	COG1126	abc transporter atp-binding protein
EPB57_RS09730	COG1410	methionine synthase
EPB57_RS09730	COG0646	methionine synthase
EPB57_RS09750	COG1335	isochorismatase
EPB57_RS09770	COG2814	Major facilitator Superfamily
EPB57_RS09775	COG0583	DNA-binding transcription factor activity
EPB57_RS09785	COG0583	DNA-binding transcription factor activity
EPB57_RS09790	COG0656	L-ascorbic acid biosynthetic process
EPB57_RS09800	COG1414	Transcriptional regulator
EPB57_RS09850	COG0840	transmembrane signaling receptor activity
EPB57_RS09855	COG1254	Belongs to the acylphosphatase family
EPB57_RS09860	COG2920	part of a sulfur-relay system
EPB57_RS09870	COG0670	Belongs to the BI1 family
EPB57_RS09875	COG1126	abc transporter atp-binding protein
EPB57_RS09880	COG0765	amino acid transport
EPB57_RS09885	COG4597	amino acid ABC transporter
EPB57_RS09890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EPB57_RS09900	COG1666	GTP binding
EPB57_RS09905	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EPB57_RS09930	COG3008	intermembrane lipid transfer
EPB57_RS09935	COG2995	paraquat-inducible protein a
EPB57_RS09940	COG1132	(ABC) transporter
EPB57_RS09945	COG1956	GAF domain-containing protein
EPB57_RS09950	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
EPB57_RS09965	COG0308	aminopeptidase N
EPB57_RS09975	COG2902	Dehydrogenase
EPB57_RS09980	COG0167	dihydroorotate dehydrogenase activity
EPB57_RS09990	COG0116	Belongs to the methyltransferase superfamily
EPB57_RS09990	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EPB57_RS10000	COG0488	(ABC) transporter
EPB57_RS10015	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EPB57_RS10020	COG1067	ATP-dependent peptidase activity
EPB57_RS10025	COG3120	sequence-specific DNA binding
EPB57_RS10230	COG0784	Response regulator, receiver
EPB57_RS10230	COG2205	protein histidine kinase activity
EPB57_RS10245	COG3278	Belongs to the heme-copper respiratory oxidase family
EPB57_RS10260	COG2010	Cytochrome c
EPB57_RS10270	COG2217	Heavy metal translocating P-type atpase
EPB57_RS10285	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EPB57_RS10290	COG0589	response to stress
EPB57_RS10315	COG3842	ATPase activity
EPB57_RS10325	COG1177	transmembrane transport
EPB57_RS10335	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EPB57_RS10340	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EPB57_RS10345	COG0004	ammonium transporteR
EPB57_RS10375	COG0437	4 iron, 4 sulfur cluster binding
EPB57_RS10380	COG3383	formate dehydrogenase (NAD+) activity
EPB57_RS10380	COG0243	molybdopterin cofactor binding
EPB57_RS10390	COG3381	protein complex oligomerization
EPB57_RS10410	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EPB57_RS10415	COG0488	(ABC) transporter
EPB57_RS10425	COG4191	Histidine kinase
EPB57_RS10430	COG2204	response regulator
EPB57_RS10445	COG3842	ATPase activity
EPB57_RS10450	COG0746	molybdenum cofactor guanylyltransferase activity
EPB57_RS10455	COG0303	'Molybdopterin
EPB57_RS10465	COG1940	carbohydrate kinase activity
EPB57_RS10470	COG3148	PFAM DTW domain containing protein
EPB57_RS10505	COG0791	NLP P60 protein
EPB57_RS10515	COG3706	GGDEF domain
EPB57_RS10525	COG3001	Fructosamine kinase
EPB57_RS10535	COG0307	riboflavin synthase, alpha
EPB57_RS10540	COG0534	Mate efflux family protein
EPB57_RS10550	COG1793	dna ligase
EPB57_RS10580	COG2204	response regulator
EPB57_RS10585	COG0438	transferase activity, transferring glycosyl groups
EPB57_RS10590	COG0438	transferase activity, transferring glycosyl groups
EPB57_RS10620	COG0438	transferase activity, transferring glycosyl groups
EPB57_RS10625	COG1215	transferase activity, transferring glycosyl groups
EPB57_RS10630	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EPB57_RS10640	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EPB57_RS10655	COG1643	Atp-dependent helicase
EPB57_RS10660	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
EPB57_RS10705	COG0443	Heat shock 70 kDa protein
EPB57_RS10710	COG0443	Heat shock 70 kDa protein
EPB57_RS10730	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
EPB57_RS10735	COG0583	DNA-binding transcription factor activity
EPB57_RS10755	COG1132	(ABC) transporter
EPB57_RS10760	COG1132	(ABC) transporter
EPB57_RS10770	COG4774	siderophore transport
EPB57_RS10780	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EPB57_RS10785	COG1120	ATPase activity
EPB57_RS10800	COG0814	amino acid
EPB57_RS10810	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
EPB57_RS10820	COG0861	Integral membrane protein TerC family
EPB57_RS10830	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EPB57_RS10835	COG1328	CTP reductase activity
EPB57_RS10850	COG5001	Diguanylate cyclase
EPB57_RS10850	COG3300	MHYT domain
EPB57_RS10865	COG0471	metal ion transport
EPB57_RS10890	COG4702	Belongs to the UPF0303 family
EPB57_RS10895	COG0673	inositol 2-dehydrogenase activity
EPB57_RS10900	COG1349	DNA-binding transcription factor activity
EPB57_RS10915	COG1538	Outer membrane efflux protein
EPB57_RS10940	COG3119	arylsulfatase activity
EPB57_RS10955	COG0641	radical SAM
EPB57_RS10970	COG3119	arylsulfatase activity
EPB57_RS10975	COG0527	aspartate kinase activity
EPB57_RS10980	COG0662	Cupin 2, conserved barrel domain protein
EPB57_RS10985	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EPB57_RS10990	COG0456	acetyltransferase
EPB57_RS10995	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EPB57_RS11010	COG4175	Glycine betaine
EPB57_RS11015	COG4176	ABC-type proline glycine betaine transport system permease component
EPB57_RS11020	COG2113	Glycine betaine
EPB57_RS11025	COG1368	sulfuric ester hydrolase activity
EPB57_RS11050	COG1115	amino acid carrier protein
EPB57_RS11060	COG1280	lysine exporter protein (LysE YggA)
EPB57_RS11065	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
EPB57_RS11070	COG1560	Kdo2-lipid A biosynthetic process
EPB57_RS11085	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
EPB57_RS11090	COG3063	Type IV pilus biogenesis stability protein PilW
EPB57_RS11130	COG2315	Protein conserved in bacteria
EPB57_RS11135	COG1846	Transcriptional regulator
EPB57_RS11145	COG2200	EAL domain
EPB57_RS11150	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EPB57_RS11155	COG1012	belongs to the aldehyde dehydrogenase family
EPB57_RS11160	COG2957	Belongs to the agmatine deiminase family
EPB57_RS11170	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EPB57_RS11175	COG1012	belongs to the aldehyde dehydrogenase family
EPB57_RS11180	COG1917	Cupin 2, conserved barrel domain protein
EPB57_RS11180	COG1396	sequence-specific DNA binding
EPB57_RS11185	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
EPB57_RS11195	COG0174	glutamine synthetase
EPB57_RS11200	COG1757	Na H antiporter
EPB57_RS11215	COG1742	UPF0060 membrane protein
EPB57_RS11240	COG3755	Protein conserved in bacteria
EPB57_RS11290	COG0625	glutathione transferase activity
EPB57_RS11300	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
EPB57_RS11310	COG2195	Cleaves the N-terminal amino acid of tripeptides
EPB57_RS11320	COG0601	transmembrane transport
EPB57_RS11325	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EPB57_RS11330	COG0444	Belongs to the ABC transporter superfamily
EPB57_RS11345	COG3291	Pkd domain containing protein
EPB57_RS11360	COG1177	transmembrane transport
EPB57_RS11370	COG3842	ATPase activity
EPB57_RS11375	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EPB57_RS11380	COG2423	ornithine cyclodeaminase activity
EPB57_RS11395	COG3938	Belongs to the proline racemase family
EPB57_RS11425	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
EPB57_RS11430	COG1451	nucleotide metabolic process
EPB57_RS11440	COG0583	DNA-binding transcription factor activity
EPB57_RS11460	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
EPB57_RS11465	COG4139	cobalamin transport
EPB57_RS11470	COG2988	succinylglutamate desuccinylase activity
EPB57_RS11490	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
EPB57_RS11495	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
EPB57_RS11500	COG0702	epimerase
EPB57_RS11505	COG1823	symporter activity
EPB57_RS11510	COG2925	Exonuclease
EPB57_RS11515	COG1380	Effector of murein hydrolase LrgA
EPB57_RS11520	COG1346	cytolysis
EPB57_RS11525	COG0295	cytidine deaminase activity
EPB57_RS11530	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
EPB57_RS11535	COG0500	methyltransferase
EPB57_RS11545	COG0776	regulation of translation
EPB57_RS11555	COG0072	phenylalanine-tRNA ligase activity
EPB57_RS11555	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EPB57_RS11560	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EPB57_RS11590	COG0393	Putative heavy-metal-binding
EPB57_RS11600	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EPB57_RS11610	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EPB57_RS11625	COG2188	Transcriptional regulator
EPB57_RS11630	COG1228	amidohydrolase
EPB57_RS11635	COG0010	Belongs to the arginase family
EPB57_RS11640	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
EPB57_RS11645	COG2986	histidine ammonia-lyase
EPB57_RS11660	COG0247	lactate metabolic process
EPB57_RS11660	COG0277	FAD linked oxidase domain protein
EPB57_RS11695	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EPB57_RS11710	COG1643	Atp-dependent helicase
EPB57_RS11715	COG0281	malic enzyme
EPB57_RS11720	COG2949	membrane
EPB57_RS11725	COG0471	metal ion transport
EPB57_RS11750	COG0492	ferredoxin-NADP+ reductase activity
EPB57_RS11755	COG4988	ABC transporter
EPB57_RS11760	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EPB57_RS11770	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
EPB57_RS11780	COG4191	Histidine kinase
EPB57_RS11780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EPB57_RS11795	COG3070	regulator of competence-specific genes
EPB57_RS11810	COG2431	L-lysine efflux transmembrane transporter activity
EPB57_RS11820	COG0076	glutamate decarboxylase activity
EPB57_RS11825	COG1737	Transcriptional regulator
EPB57_RS11835	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EPB57_RS11840	COG3273	potassium ion transport
EPB57_RS11840	COG2985	domain, Protein
EPB57_RS11845	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EPB57_RS11850	COG1960	acyl-CoA dehydrogenase activity
EPB57_RS11860	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EPB57_RS11880	COG0534	Mate efflux family protein
EPB57_RS11885	COG0702	epimerase
EPB57_RS11895	COG2814	Major facilitator Superfamily
EPB57_RS11900	COG1187	pseudouridine synthase activity
EPB57_RS11905	COG1061	Type III restriction enzyme res subunit
EPB57_RS11925	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
EPB57_RS11950	COG3313	Fe-S protein
EPB57_RS11960	COG4134	Bacterial extracellular solute-binding protein
EPB57_RS11965	COG4135	transport system, permease component
EPB57_RS11970	COG4136	ATPase activity
EPB57_RS11975	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EPB57_RS11990	COG3604	Transcriptional regulator
EPB57_RS11995	COG1151	hydroxylamine reductase activity
EPB57_RS12000	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EPB57_RS12010	COG0564	pseudouridine synthase activity
EPB57_RS12015	COG0733	neurotransmitter:sodium symporter activity
EPB57_RS12025	COG0626	cystathionine gamma-synthase activity
EPB57_RS12030	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
EPB57_RS12035	COG5380	lipid catabolic process
EPB57_RS12040	COG2818	Glycosylase
EPB57_RS12060	COG1983	PspC domain protein
EPB57_RS12070	COG1842	Phage shock protein A
EPB57_RS12075	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
EPB57_RS12090	COG4171	peptide transport system, permease
EPB57_RS12100	COG4172	Belongs to the ABC transporter superfamily
EPB57_RS12110	COG1227	inorganic diphosphatase activity
EPB57_RS12125	COG0243	molybdopterin cofactor binding
EPB57_RS12130	COG3005	denitrification pathway
EPB57_RS12135	COG4459	periplasmic nitrate reductase
EPB57_RS12140	COG0390	transport system, permease component
EPB57_RS12155	COG2116	formate transmembrane transporter activity
EPB57_RS12180	COG1434	Gram-negative-bacterium-type cell wall biogenesis
EPB57_RS12185	COG1435	thymidine kinase activity
EPB57_RS12190	COG0215	cysteine-tRNA ligase activity
EPB57_RS12195	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EPB57_RS12200	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EPB57_RS12205	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
EPB57_RS12210	COG3012	SEC-C Motif Domain Protein
EPB57_RS12215	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EPB57_RS12215	COG0140	phosphoribosyl-ATP diphosphatase activity
EPB57_RS12225	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EPB57_RS12230	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EPB57_RS12235	COG0131	Imidazoleglycerol-phosphate dehydratase
EPB57_RS12235	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EPB57_RS12245	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EPB57_RS12260	COG1757	Na H antiporter
EPB57_RS12270	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EPB57_RS12285	COG2915	High frequency lysogenization protein hflD homolog
EPB57_RS12290	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EPB57_RS12300	COG2268	Band 7 protein
EPB57_RS12310	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EPB57_RS12325	COG0300	oxidoreductase activity
EPB57_RS12345	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
EPB57_RS12370	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EPB57_RS12400	COG1674	ftsk spoiiie
EPB57_RS12420	COG0583	DNA-binding transcription factor activity
EPB57_RS12445	COG3568	Endonuclease Exonuclease Phosphatase
EPB57_RS12470	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EPB57_RS12475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EPB57_RS12495	COG1271	oxidase subunit
EPB57_RS12500	COG1294	oxidase, subunit
EPB57_RS12525	COG0754	glutathionylspermidine amidase activity
EPB57_RS12535	COG3766	membrane
EPB57_RS12545	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EPB57_RS12550	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
EPB57_RS12555	COG2885	chlorophyll binding
EPB57_RS12560	COG0823	Involved in the tonB-independent uptake of proteins
EPB57_RS12575	COG0811	peptide transport
EPB57_RS12580	COG0824	Thioesterase
EPB57_RS12590	COG4890	Cyd operon protein YbgT
EPB57_RS12595	COG1294	oxidase, subunit
EPB57_RS12600	COG1271	oxidase subunit
EPB57_RS12605	COG2255	four-way junction helicase activity
EPB57_RS12610	COG0632	four-way junction helicase activity
EPB57_RS12615	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
EPB57_RS12620	COG0217	transcriptional regulatory protein
EPB57_RS12630	COG1801	Protein of unknown function DUF72
EPB57_RS12640	COG0500	methyltransferase
EPB57_RS12650	COG4067	protein conserved in archaea
EPB57_RS12650	COG0189	ligase activity
EPB57_RS12670	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
EPB57_RS12675	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
EPB57_RS12680	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
EPB57_RS12685	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EPB57_RS12690	COG1434	Gram-negative-bacterium-type cell wall biogenesis
EPB57_RS12700	COG0745	RESPONSE REGULATOR receiver
EPB57_RS12705	COG3381	protein complex oligomerization
EPB57_RS12710	COG1609	Transcriptional regulator
EPB57_RS12715	COG3070	regulator of competence-specific genes
EPB57_RS12735	COG0297	glycogen (starch) synthase activity
EPB57_RS12740	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EPB57_RS12745	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EPB57_RS12765	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
EPB57_RS12770	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
EPB57_RS12775	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EPB57_RS12780	COG0542	response to heat
EPB57_RS12785	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
EPB57_RS12790	COG1278	Cold shock
EPB57_RS12800	COG1187	pseudouridine synthase activity
EPB57_RS12805	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
EPB57_RS12810	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EPB57_RS12815	COG1199	ATP-dependent helicase activity
EPB57_RS12820	COG0730	response to heat
EPB57_RS12825	COG3923	Primosomal replication protein n
EPB57_RS12835	COG0708	Exodeoxyribonuclease III
EPB57_RS12880	COG1882	Formate acetyltransferase
EPB57_RS12890	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EPB57_RS12900	COG3013	Belongs to the UPF0304 family
EPB57_RS12905	COG2766	serine protein kinase
EPB57_RS12910	COG2718	Belongs to the UPF0229 family
EPB57_RS12915	COG2719	SpoVR family
EPB57_RS12935	COG1132	(ABC) transporter
EPB57_RS12940	COG0658	competence protein
EPB57_RS12940	COG2333	competence protein COMEC
EPB57_RS12950	COG4591	ABC-type transport system involved in lipoprotein release permease component
EPB57_RS12955	COG1136	(ABC) transporter
EPB57_RS12960	COG4591	ABC-type transport system involved in lipoprotein release permease component
EPB57_RS12970	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EPB57_RS12985	COG1252	NADH dehydrogenase
EPB57_RS12990	COG3150	esterase
EPB57_RS13015	COG0537	adenosine 5'-monophosphoramidase activity
EPB57_RS13040	COG0516	GMP reductase activity
EPB57_RS13040	COG0517	IMP dehydrogenase activity
EPB57_RS13045	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EPB57_RS13070	COG3126	Type III secretion system lipoprotein chaperone (YscW)
EPB57_RS13075	COG1946	Acyl-CoA thioesterase
EPB57_RS13090	COG1522	sequence-specific DNA binding
EPB57_RS13095	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EPB57_RS13115	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EPB57_RS13120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EPB57_RS13165	COG0477	Major facilitator Superfamily
EPB57_RS13170	COG2855	membrane
EPB57_RS13190	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
EPB57_RS13200	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
EPB57_RS13205	COG1169	isochorismate synthase
EPB57_RS13210	COG0436	Aminotransferase
EPB57_RS13215	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
EPB57_RS13220	COG0232	Belongs to the dGTPase family. Type 2 subfamily
EPB57_RS13235	COG1555	photosystem II stabilization
EPB57_RS13240	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EPB57_RS13245	COG0776	regulation of translation
EPB57_RS13250	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EPB57_RS13255	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EPB57_RS13265	COG0544	peptidyl-prolyl cis-trans isomerase activity
EPB57_RS13280	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EPB57_RS13285	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
EPB57_RS13290	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EPB57_RS13295	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EPB57_RS13310	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EPB57_RS13315	COG0569	domain protein
EPB57_RS13320	COG0513	Belongs to the DEAD box helicase family
EPB57_RS13355	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EPB57_RS13360	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EPB57_RS13375	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EPB57_RS13380	COG1216	Glycosyl transferase, family 2
EPB57_RS13385	COG2986	histidine ammonia-lyase
EPB57_RS13410	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EPB57_RS13420	COG1028	Short-chain dehydrogenase reductase Sdr
EPB57_RS13435	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EPB57_RS13440	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EPB57_RS13450	COG2951	lytic endotransglycosylase activity
EPB57_RS13455	COG3100	YcgL domain-containing protein
EPB57_RS13460	COG0850	regulation of cytokinetic process
EPB57_RS13465	COG2894	cell division
EPB57_RS13470	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
EPB57_RS13475	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
EPB57_RS13480	COG0318	PFAM AMP-dependent synthetase and ligase
EPB57_RS13485	COG2267	carboxylic ester hydrolase activity
EPB57_RS13490	COG3065	identical protein binding
EPB57_RS13500	COG1214	PFAM Peptidase M22, glycoprotease
EPB57_RS13505	COG1199	ATP-dependent helicase activity
EPB57_RS13510	COG0788	formyltetrahydrofolate deformylase activity
EPB57_RS13525	COG3102	Protein conserved in bacteria
EPB57_RS13535	COG0018	arginyl-trna synthetase
EPB57_RS13560	COG1918	ferrous iron import across plasma membrane
EPB57_RS13565	COG4977	sequence-specific DNA binding
EPB57_RS13570	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
EPB57_RS13575	COG1121	(ABC) transporter
EPB57_RS13580	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EPB57_RS13590	COG0045	succinate-CoA ligase (ADP-forming) activity
EPB57_RS13595	COG0508	dehydrogenase complex catalyzes the overall conversion of
EPB57_RS13600	COG0567	Dehydrogenase, E1 component
EPB57_RS13605	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EPB57_RS13610	COG1053	succinate dehydrogenase
EPB57_RS13615	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
EPB57_RS13630	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EPB57_RS13640	COG0033	Phosphoglucomutase
EPB57_RS13645	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
EPB57_RS13650	COG0596	Alpha beta hydrolase
EPB57_RS13660	COG0716	FMN binding
EPB57_RS13670	COG0735	belongs to the Fur family
EPB57_RS13675	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EPB57_RS13680	COG1263	PTS System
EPB57_RS13680	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EPB57_RS13680	COG2190	(PTS) system
EPB57_RS13690	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EPB57_RS13695	COG1846	Transcriptional regulator
EPB57_RS13695	COG1940	carbohydrate kinase activity
EPB57_RS13700	COG4651	solute:proton antiporter activity
EPB57_RS13700	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EPB57_RS13705	COG0367	asparagine synthase
EPB57_RS13710	COG0250	Participates in transcription elongation, termination and antitermination
EPB57_RS13715	COG3104	oligopeptide transport
EPB57_RS13720	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EPB57_RS13730	COG0326	Molecular chaperone. Has ATPase activity
EPB57_RS13735	COG3710	Transcriptional regulator
EPB57_RS13755	COG0622	Phosphoesterase
EPB57_RS13785	COG1090	epimerase
EPB57_RS13790	COG0300	oxidoreductase activity
EPB57_RS13800	COG3118	belongs to the thioredoxin family
EPB57_RS13810	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
EPB57_RS13815	COG1215	transferase activity, transferring glycosyl groups
EPB57_RS13820	COG1215	transferase activity, transferring glycosyl groups
EPB57_RS13835	COG2194	sulfuric ester hydrolase activity
EPB57_RS13840	COG0330	HflC and HflK could
EPB57_RS13860	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EPB57_RS13865	COG3115	cell septum assembly
EPB57_RS13870	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
EPB57_RS13875	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EPB57_RS13885	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EPB57_RS13890	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EPB57_RS13895	COG2190	(PTS) system
EPB57_RS13900	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EPB57_RS13905	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EPB57_RS13915	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EPB57_RS13920	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EPB57_RS13930	COG3951	Flagellar rod assembly protein muramidase FlgJ
EPB57_RS13930	COG1705	Flagellar rod assembly protein muramidase FlgJ
EPB57_RS13935	COG1706	bacterial-type flagellum-dependent cell motility
EPB57_RS13940	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
EPB57_RS13950	COG4787	bacterial-type flagellum-dependent cell motility
EPB57_RS13955	COG1749	Flagellar hook protein flgE
EPB57_RS13965	COG1558	bacterial-type flagellum-dependent cell motility
EPB57_RS13970	COG1815	bacterial-type flagellum-dependent cell motility
EPB57_RS13975	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EPB57_RS13980	COG0784	Response regulator, receiver
EPB57_RS13980	COG0835	chemotaxis
EPB57_RS14035	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
EPB57_RS14045	COG2608	mercury ion transmembrane transporter activity
EPB57_RS14045	COG2217	Heavy metal translocating P-type atpase
EPB57_RS14085	COG2840	Smr protein MutS2
EPB57_RS14090	COG1187	pseudouridine synthase activity
EPB57_RS14095	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EPB57_RS14100	COG0737	Belongs to the 5'-nucleotidase family
EPB57_RS14105	COG2877	3-deoxy-8-phosphooctulonate synthase activity
EPB57_RS14110	COG2912	Transglutaminase-like superfamily
EPB57_RS14115	COG3094	Invasion gene expression up-regulator, SirB
EPB57_RS14120	COG2890	protein-(glutamine-N5) methyltransferase activity
EPB57_RS14130	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EPB57_RS14135	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
EPB57_RS14140	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EPB57_RS14145	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EPB57_RS14150	COG0193	aminoacyl-tRNA hydrolase activity
EPB57_RS14155	COG0012	GTP binding
EPB57_RS14265	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EPB57_RS14275	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EPB57_RS14280	COG1702	phosphate starvation-inducible protein PhoH
EPB57_RS14285	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EPB57_RS14290	COG4535	Mg2 and Co2 transporter CorC
EPB57_RS14295	COG0815	Transfers the fatty acyl group on membrane lipoproteins
EPB57_RS14300	COG2888	peptidyl-tyrosine sulfation
EPB57_RS14305	COG0495	leucyl-tRNA aminoacylation
EPB57_RS14310	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
EPB57_RS14315	COG1466	dna polymerase III delta subunit
EPB57_RS14320	COG0799	negative regulation of ribosome biogenesis
EPB57_RS14325	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EPB57_RS14330	COG0768	penicillin binding
EPB57_RS14335	COG0772	Belongs to the SEDS family
EPB57_RS14340	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EPB57_RS14345	COG1686	Belongs to the peptidase S11 family
EPB57_RS14355	COG0321	lipoyl(octanoyl) transferase activity
EPB57_RS14360	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EPB57_RS14365	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EPB57_RS14370	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EPB57_RS14385	COG0366	Alpha amylase catalytic
EPB57_RS14390	COG1263	PTS System
EPB57_RS14390	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EPB57_RS14400	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EPB57_RS14405	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EPB57_RS14410	COG2011	ABC-type metal ion transport system permease component
EPB57_RS14415	COG1464	Belongs to the NlpA lipoprotein family
EPB57_RS14420	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
EPB57_RS14430	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EPB57_RS14430	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EPB57_RS14445	COG1611	Belongs to the LOG family
EPB57_RS14450	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EPB57_RS14460	COG2363	Small membrane protein
EPB57_RS14470	COG0583	DNA-binding transcription factor activity
EPB57_RS14475	COG0301	tRNA thio-modification
EPB57_RS14475	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EPB57_RS14485	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EPB57_RS14490	COG1722	exodeoxyribonuclease VII activity
EPB57_RS14495	COG0142	geranyltranstransferase activity
EPB57_RS14505	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EPB57_RS14510	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
EPB57_RS14520	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EPB57_RS14535	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EPB57_RS14535	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EPB57_RS14540	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EPB57_RS14545	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EPB57_RS14550	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EPB57_RS14560	COG1073	alpha beta
EPB57_RS14565	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
EPB57_RS14570	COG2252	PERMEase
EPB57_RS14575	COG2195	Cleaves the N-terminal amino acid of tripeptides
EPB57_RS14605	COG0047	phosphoribosylformylglycinamidine synthase activity
EPB57_RS14605	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EPB57_RS14610	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
EPB57_RS14625	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
EPB57_RS14660	COG0484	heat shock protein binding
EPB57_RS14670	COG1301	dicarboxylic acid transport
EPB57_RS14675	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EPB57_RS14680	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EPB57_RS14690	COG0497	DNA recombination
EPB57_RS14700	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EPB57_RS14705	COG2914	Belongs to the UPF0125 (RnfH) family
EPB57_RS14710	COG2867	negative regulation of translational initiation
EPB57_RS14715	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EPB57_RS14735	COG0583	DNA-binding transcription factor activity
EPB57_RS14740	COG3153	acetyltransferase
EPB57_RS14740	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EPB57_RS14760	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EPB57_RS14765	COG2873	o-acetylhomoserine
EPB57_RS14780	COG1115	amino acid carrier protein
EPB57_RS14785	COG1584	GPR1 FUN34 yaaH family protein
EPB57_RS14795	COG1757	Na H antiporter
EPB57_RS14800	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EPB57_RS14800	COG0519	Catalyzes the synthesis of GMP from XMP
EPB57_RS14805	COG0517	IMP dehydrogenase activity
EPB57_RS14805	COG0516	GMP reductase activity
EPB57_RS14825	COG1160	GTP binding
EPB57_RS14830	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EPB57_RS14835	COG2976	Protein conserved in bacteria
EPB57_RS14840	COG0124	histidyl-tRNA synthetase
EPB57_RS14845	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EPB57_RS14865	COG0105	UTP biosynthetic process
EPB57_RS14875	COG2975	iron-sulfur cluster assembly
EPB57_RS14880	COG0633	Ferredoxin
EPB57_RS14885	COG0443	Heat shock 70 kDa protein
EPB57_RS14900	COG0822	iron-sulfur transferase activity
EPB57_RS14905	COG1104	cysteine desulfurase activity
EPB57_RS14915	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
EPB57_RS14920	COG0483	inositol monophosphate 1-phosphatase activity
EPB57_RS14925	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EPB57_RS14930	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EPB57_RS14935	COG1862	Preprotein translocase
EPB57_RS14945	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EPB57_RS14955	COG0517	IMP dehydrogenase activity
EPB57_RS14965	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EPB57_RS14975	COG0583	DNA-binding transcription factor activity
EPB57_RS14980	COG0450	alkyl hydroperoxide reductase
EPB57_RS14985	COG3142	Participates in the control of copper homeostasis
EPB57_RS14995	COG0704	Plays a role in the regulation of phosphate uptake
EPB57_RS15000	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EPB57_RS15005	COG0581	inorganic phosphate transmembrane transporter activity
EPB57_RS15010	COG0573	inorganic phosphate transmembrane transporter activity
EPB57_RS15015	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EPB57_RS15020	COG0248	Ppx GppA phosphatase
EPB57_RS15030	COG5002	protein histidine kinase activity
EPB57_RS15035	COG0745	RESPONSE REGULATOR receiver
EPB57_RS15040	COG2974	May be involved in recombination
EPB57_RS15045	COG0826	peptidase U32
EPB57_RS15050	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EPB57_RS15110	COG0542	response to heat
EPB57_RS15120	COG0564	pseudouridine synthase activity
EPB57_RS15125	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EPB57_RS15135	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EPB57_RS15140	COG1605	Chorismate mutase
EPB57_RS15140	COG0077	Prephenate dehydratase
EPB57_RS15145	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
EPB57_RS15150	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
EPB57_RS15160	COG0488	(ABC) transporter
EPB57_RS15170	COG0739	heme binding
EPB57_RS15175	COG0287	Prephenate dehydrogenase
EPB57_RS15175	COG1605	Chorismate mutase
EPB57_RS15180	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EPB57_RS15185	COG1472	Belongs to the glycosyl hydrolase 3 family
EPB57_RS15190	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EPB57_RS15210	COG1966	Carbon starvation protein
EPB57_RS15215	COG3275	phosphorelay sensor kinase activity
EPB57_RS15220	COG3279	Response regulator of the LytR AlgR family
EPB57_RS15230	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EPB57_RS15235	COG1047	Peptidyl-prolyl cis-trans
EPB57_RS15250	COG0196	riboflavin kinase activity
EPB57_RS15255	COG0728	peptidoglycan biosynthetic process
EPB57_RS15260	COG0268	Binds directly to 16S ribosomal RNA
EPB57_RS15265	COG0640	Transcriptional regulator
EPB57_RS15270	COG0583	DNA-binding transcription factor activity
EPB57_RS15275	COG1283	sodium-dependent phosphate transmembrane transporter activity
EPB57_RS15285	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
EPB57_RS15290	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EPB57_RS15295	COG0730	response to heat
EPB57_RS15325	COG0667	Aldo Keto reductase
EPB57_RS15335	COG2204	response regulator
EPB57_RS15350	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EPB57_RS15355	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EPB57_RS15360	COG4974	Belongs to the 'phage' integrase family
EPB57_RS15365	COG0716	FMN binding
EPB57_RS15375	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
EPB57_RS15380	COG0513	Belongs to the DEAD box helicase family
EPB57_RS15385	COG3022	response to hydroperoxide
EPB57_RS15390	COG1115	amino acid carrier protein
EPB57_RS15405	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EPB57_RS15415	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
EPB57_RS15420	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
EPB57_RS15430	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
EPB57_RS15435	COG0083	homoserine kinase activity
EPB57_RS15455	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EPB57_RS15470	COG0745	RESPONSE REGULATOR receiver
EPB57_RS15480	COG0784	Response regulator, receiver
EPB57_RS15480	COG5002	protein histidine kinase activity
EPB57_RS15480	COG2198	Histidine kinase
EPB57_RS15485	COG4251	negative regulation of phosphorylation
EPB57_RS15485	COG5001	Diguanylate cyclase
EPB57_RS15485	COG2203	Gaf domain
EPB57_RS15485	COG3706	GGDEF domain
EPB57_RS15490	COG1242	4 iron, 4 sulfur cluster binding
EPB57_RS15495	COG0070	glutamate synthase
EPB57_RS15495	COG0069	glutamate synthase activity
EPB57_RS15495	COG0067	glutamate synthase
EPB57_RS15505	COG0070	glutamate synthase
EPB57_RS15505	COG0069	glutamate synthase activity
EPB57_RS15505	COG0067	glutamate synthase
EPB57_RS15510	COG0493	'glutamate synthase
EPB57_RS15520	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EPB57_RS15535	COG2860	membrane
EPB57_RS15540	COG0583	DNA-binding transcription factor activity
EPB57_RS15545	COG0730	response to heat
EPB57_RS15560	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EPB57_RS15565	COG0505	Belongs to the CarA family
EPB57_RS15575	COG0494	nUDIX hydrolase
EPB57_RS15580	COG0653	protein targeting
EPB57_RS15590	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
EPB57_RS15595	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EPB57_RS15600	COG0849	cell division
EPB57_RS15605	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EPB57_RS15620	COG0772	Belongs to the SEDS family
EPB57_RS15625	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EPB57_RS15630	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EPB57_RS15635	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EPB57_RS15640	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EPB57_RS15645	COG0768	penicillin binding
EPB57_RS15650	COG3116	cell division
EPB57_RS15670	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EPB57_RS15685	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EPB57_RS15690	COG2823	Periplasmic or secreted lipoprotein
EPB57_RS15695	COG2969	positive regulation of protein catabolic process
EPB57_RS15700	COG0625	glutathione transferase activity
EPB57_RS15705	COG2857	Cytochrome c1
EPB57_RS15710	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EPB57_RS15715	COG0723	plastoquinol--plastocyanin reductase activity
EPB57_RS15720	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EPB57_RS15735	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
EPB57_RS15745	COG3105	Protein conserved in bacteria
EPB57_RS15755	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EPB57_RS15760	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EPB57_RS15770	COG3150	esterase
EPB57_RS15780	COG3151	Protein conserved in bacteria
EPB57_RS15785	COG0494	nUDIX hydrolase
EPB57_RS15790	COG1538	Outer membrane efflux protein
EPB57_RS15795	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
EPB57_RS15795	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EPB57_RS15800	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
EPB57_RS15815	COG3025	triphosphatase activity
EPB57_RS15820	COG1392	Phosphate transport regulator
EPB57_RS15830	COG4991	sh3 domain protein
EPB57_RS15835	COG0405	Gamma-glutamyltransferase
EPB57_RS15845	COG3267	Type II secretory pathway component ExeA
EPB57_RS15845	COG3409	Peptidoglycan-binding domain 1 protein
EPB57_RS15855	COG1968	undecaprenyl-diphosphatase activity
EPB57_RS15860	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EPB57_RS15865	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EPB57_RS15870	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EPB57_RS15875	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EPB57_RS15880	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EPB57_RS15885	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EPB57_RS15890	COG1610	YqeY-like protein
EPB57_RS15895	COG0358	DNA primase activity
EPB57_RS15935	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
EPB57_RS15935	COG2213	PTS system mannitol-specific
EPB57_RS15945	COG3722	fumarate hydratase activity
EPB57_RS15960	COG1461	Dihydroxyacetone kinase
EPB57_RS15965	COG2376	Dihydroxyacetone kinase
EPB57_RS15975	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EPB57_RS15980	COG1349	DNA-binding transcription factor activity
EPB57_RS15985	COG0469	pyruvate kinase activity
EPB57_RS16000	COG0440	acetolactate synthase activity
EPB57_RS16005	COG0028	Belongs to the TPP enzyme family
EPB57_RS16010	COG1022	Amp-dependent synthetase and ligase
EPB57_RS16015	COG0583	DNA-binding transcription factor activity
EPB57_RS16040	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EPB57_RS16045	COG0473	3-isopropylmalate dehydrogenase activity
EPB57_RS16065	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
EPB57_RS16070	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
EPB57_RS16075	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EPB57_RS16080	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EPB57_RS16085	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EPB57_RS16090	COG2967	ApaG domain
EPB57_RS16095	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EPB57_RS16100	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EPB57_RS16110	COG2966	Psort location CytoplasmicMembrane, score
EPB57_RS16115	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EPB57_RS16125	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EPB57_RS16130	COG0142	geranyltranstransferase activity
EPB57_RS16155	COG2358	TRAP transporter, solute receptor (TAXI family
EPB57_RS16170	COG1902	pentaerythritol trinitrate reductase activity
EPB57_RS16175	COG0583	DNA-binding transcription factor activity
EPB57_RS16180	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
EPB57_RS16185	COG1178	ABC-type Fe3 transport system permease component
EPB57_RS16190	COG4143	(ABC) transporter
EPB57_RS16195	COG0163	prenyltransferase activity
EPB57_RS16200	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EPB57_RS16210	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
EPB57_RS16215	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
EPB57_RS16225	COG2105	PFAM AIG2 family protein
EPB57_RS16230	COG2911	Protein conserved in bacteria
EPB57_RS16235	COG0729	surface antigen
EPB57_RS16240	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EPB57_RS16250	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
EPB57_RS16265	COG4181	ATPase activity
EPB57_RS16285	COG0529	Catalyzes the synthesis of activated sulfate
EPB57_RS16290	COG0471	metal ion transport
EPB57_RS16290	COG3273	potassium ion transport
EPB57_RS16295	COG2895	sulfate adenylyltransferase (ATP) activity
EPB57_RS16300	COG0175	sulfate reduction
EPB57_RS16305	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EPB57_RS16305	COG1648	precorrin-2 dehydrogenase activity
EPB57_RS16320	COG0513	Belongs to the DEAD box helicase family
EPB57_RS16325	COG2153	protein acetylation
EPB57_RS16335	COG0545	Peptidyl-prolyl cis-trans isomerase
EPB57_RS16345	COG0203	ribosomal protein L17
EPB57_RS16350	COG0202	RNA polymerase activity
EPB57_RS16360	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EPB57_RS16365	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EPB57_RS16370	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EPB57_RS16375	COG0201	protein transport
EPB57_RS16380	COG0200	Binds to the 23S rRNA
EPB57_RS16385	COG1841	ribosomal large subunit assembly
EPB57_RS16400	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
EPB57_RS16405	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EPB57_RS16415	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EPB57_RS16420	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EPB57_RS16430	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EPB57_RS16435	COG0255	Belongs to the universal ribosomal protein uL29 family
EPB57_RS16445	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EPB57_RS16450	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EPB57_RS16455	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EPB57_RS16460	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EPB57_RS16470	COG0088	Forms part of the polypeptide exit tunnel
EPB57_RS16475	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EPB57_RS16485	COG0254	rRNA binding
EPB57_RS16495	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EPB57_RS16500	COG1609	Transcriptional regulator
EPB57_RS16510	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EPB57_RS16515	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
EPB57_RS16520	COG1575	Belongs to the MenA family. Type 1 subfamily
EPB57_RS16525	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EPB57_RS16535	COG1494	fructose-1,6-bisphosphatase
EPB57_RS16565	COG0149	triose-phosphate isomerase activity
EPB57_RS16585	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EPB57_RS16595	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EPB57_RS16600	COG0438	transferase activity, transferring glycosyl groups
EPB57_RS16630	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
EPB57_RS16635	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
EPB57_RS16640	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EPB57_RS16645	COG2877	3-deoxy-8-phosphooctulonate synthase activity
EPB57_RS16650	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
EPB57_RS16690	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
EPB57_RS16690	COG0517	IMP dehydrogenase activity
EPB57_RS16725	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EPB57_RS16735	COG1560	Kdo2-lipid A biosynthetic process
EPB57_RS16745	COG0859	PFAM glycosyl transferase family 9
EPB57_RS16755	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EPB57_RS16795	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
EPB57_RS16805	COG3642	lipopolysaccharide core region biosynthetic process
EPB57_RS16810	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EPB57_RS16815	COG0859	PFAM glycosyl transferase family 9
EPB57_RS16820	COG0463	Glycosyl transferase, family 2
EPB57_RS16835	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EPB57_RS16860	COG2003	Belongs to the UPF0758 family
EPB57_RS16865	COG0840	transmembrane signaling receptor activity
EPB57_RS16870	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EPB57_RS16875	COG1309	transcriptional regulator
EPB57_RS16880	COG1560	Kdo2-lipid A biosynthetic process
EPB57_RS16885	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EPB57_RS16890	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EPB57_RS16895	COG1561	YicC-like family, N-terminal region
EPB57_RS16905	COG4608	Belongs to the ABC transporter superfamily
EPB57_RS16910	COG0444	Belongs to the ABC transporter superfamily
EPB57_RS16915	COG0747	negative chemotaxis
EPB57_RS16920	COG4239	(ABC) transporter, permease
EPB57_RS16925	COG4174	ABC transporter (Permease)
EPB57_RS16950	COG0811	peptide transport
EPB57_RS16955	COG0848	biopolymer transport protein
EPB57_RS16970	COG0194	GDP metabolic process
EPB57_RS16975	COG1758	RNA polymerase activity
EPB57_RS16980	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EPB57_RS16985	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EPB57_RS16990	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EPB57_RS16995	COG2233	PERMEase
EPB57_RS17015	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EPB57_RS17025	COG2183	response to ionizing radiation
EPB57_RS17040	COG1040	competence protein
EPB57_RS17050	COG0494	nUDIX hydrolase
EPB57_RS17055	COG1218	3'(2'),5'-bisphosphate nucleotidase
EPB57_RS17065	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
EPB57_RS17070	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
EPB57_RS17075	COG3156	type II secretion system protein K
EPB57_RS17080	COG4795	General secretion pathway protein
EPB57_RS17085	COG2165	general secretion pathway protein
EPB57_RS17090	COG2165	general secretion pathway protein
EPB57_RS17095	COG2165	general secretion pathway protein
EPB57_RS17100	COG1459	type II secretion system
EPB57_RS17105	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EPB57_RS17115	COG3031	protein transport across the cell outer membrane
EPB57_RS17120	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EPB57_RS17125	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EPB57_RS17130	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
EPB57_RS17140	COG0456	acetyltransferase
EPB57_RS17145	COG1490	D-aminoacyl-tRNA deacylase activity
EPB57_RS17150	COG1295	ribonuclease BN
EPB57_RS17165	COG1217	gtp-binding protein TYPA
EPB57_RS17170	COG0174	glutamine synthetase
EPB57_RS17180	COG3852	Histidine kinase
EPB57_RS17185	COG2204	response regulator
EPB57_RS17195	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EPB57_RS17230	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EPB57_RS17235	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EPB57_RS17235	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EPB57_RS17245	COG0456	acetyltransferase
EPB57_RS17260	COG0084	hydrolase, TatD family'
EPB57_RS17270	COG0805	protein transport
EPB57_RS17275	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EPB57_RS17285	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EPB57_RS17290	COG3165	ubiquinone biosynthetic process from chorismate
EPB57_RS17295	COG2226	methyltransferase
EPB57_RS17300	COG1322	Protein conserved in bacteria
EPB57_RS17315	COG0628	permease
EPB57_RS17345	COG1597	lipid kinase activity
EPB57_RS17375	COG2081	HI0933 family
EPB57_RS17385	COG1528	Iron-storage protein
EPB57_RS17390	COG0589	response to stress
EPB57_RS17405	COG0742	ribosomal rna small subunit methyltransferase
EPB57_RS17410	COG5001	Diguanylate cyclase
EPB57_RS17410	COG5002	protein histidine kinase activity
EPB57_RS17415	COG1522	sequence-specific DNA binding
EPB57_RS17425	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
EPB57_RS17430	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EPB57_RS17435	COG0583	DNA-binding transcription factor activity
EPB57_RS17440	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
EPB57_RS17445	COG0800	Aldolase
EPB57_RS17450	COG2610	gluconate transmembrane transporter activity
EPB57_RS17455	COG3265	gluconokinase activity
EPB57_RS17460	COG0129	dihydroxy-acid dehydratase activity
EPB57_RS17475	COG0583	DNA-binding transcription factor activity
EPB57_RS17480	COG1609	Transcriptional regulator
EPB57_RS17520	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EPB57_RS17525	COG0601	transmembrane transport
EPB57_RS17530	COG4166	transmembrane transport
EPB57_RS17590	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EPB57_RS17595	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EPB57_RS17600	COG2960	long-chain fatty acid transporting porin activity
EPB57_RS17605	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EPB57_RS17610	COG0583	DNA-binding transcription factor activity
EPB57_RS17655	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EPB57_RS17660	COG1739	Uncharacterized protein family UPF0029
EPB57_RS17670	COG0183	Belongs to the thiolase family
EPB57_RS17675	COG0604	alcohol dehydrogenase
EPB57_RS17690	COG0425	Belongs to the sulfur carrier protein TusA family
EPB57_RS17700	COG2119	membrane
EPB57_RS17715	COG0366	Alpha amylase catalytic
EPB57_RS17720	COG3977	Valine--pyruvate aminotransferase
EPB57_RS17725	COG0071	Belongs to the small heat shock protein (HSP20) family
EPB57_RS17740	COG0187	DNA topoisomerase II activity
EPB57_RS17750	COG0592	DNA-directed DNA polymerase activity
EPB57_RS17755	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EPB57_RS17775	COG1126	abc transporter atp-binding protein
EPB57_RS17785	COG0594	ribonuclease P activity
EPB57_RS17795	COG0706	membrane insertase activity
EPB57_RS17805	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EPB57_RS17810	COG0445	tRNA wobble uridine modification
EPB57_RS17815	COG0357	Ribosomal RNA small subunit methyltransferase G
EPB57_RS17820	COG1192	Involved in chromosome partitioning
EPB57_RS17825	COG1475	DNA binding
EPB57_RS17830	COG3312	ion transport
EPB57_RS17835	COG0356	it plays a direct role in the translocation of protons across the membrane
EPB57_RS17845	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EPB57_RS17850	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EPB57_RS17855	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EPB57_RS17860	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EPB57_RS17865	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EPB57_RS17870	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EPB57_RS17880	COG0765	amino acid transport
EPB57_RS17890	COG2814	Major facilitator Superfamily
EPB57_RS17895	COG0583	DNA-binding transcription factor activity
EPB57_RS17905	COG0129	dihydroxy-acid dehydratase activity
EPB57_RS17910	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EPB57_RS17915	COG3978	acetolactate synthase activity
EPB57_RS17925	COG0606	chelatase, subunit chli
EPB57_RS17935	COG0204	Acyl-transferase
EPB57_RS17940	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EPB57_RS17945	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EPB57_RS17955	COG3084	Protein conserved in bacteria
EPB57_RS17965	COG4326	sporulation control protein
EPB57_RS17970	COG1272	protein, Hemolysin III
EPB57_RS17980	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EPB57_RS17985	COG0569	domain protein
EPB57_RS17990	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EPB57_RS17990	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EPB57_RS17995	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EPB57_RS18000	COG0242	peptide deformylase activity
EPB57_RS18010	COG0758	DNA mediated transformation
EPB57_RS18015	COG2922	Belongs to the Smg family
EPB57_RS18020	COG0551	DNA topoisomerase type I activity
EPB57_RS18025	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EPB57_RS18030	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EPB57_RS18035	COG0009	L-threonylcarbamoyladenylate synthase
EPB57_RS18055	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EPB57_RS18105	COG2132	Multicopper oxidase
EPB57_RS18125	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EPB57_RS18130	COG2104	thiamine diphosphate biosynthetic process
EPB57_RS18145	COG0006	proline dipeptidase activity
EPB57_RS18145	COG0006	proline dipeptidase activity
EPB57_RS18175	COG3220	belongs to the UPF0276 family
EPB57_RS18185	COG0210	DNA helicase
EPB57_RS18195	COG0405	Gamma-glutamyltransferase
EPB57_RS18200	COG1280	lysine exporter protein (LysE YggA)
EPB57_RS18210	COG2962	Rard protein
EPB57_RS18215	COG0514	ATP-dependent DNA helicase (RecQ)
EPB57_RS18225	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
EPB57_RS18235	COG0248	Ppx GppA phosphatase
EPB57_RS18240	COG0513	Belongs to the DEAD box helicase family
EPB57_RS18245	COG3118	belongs to the thioredoxin family
EPB57_RS18260	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
EPB57_RS18265	COG0633	Ferredoxin
EPB57_RS18310	COG3071	HemY protein
EPB57_RS18315	COG2959	enzyme of heme biosynthesis
EPB57_RS18320	COG1587	Uroporphyrinogen-III synthase
EPB57_RS18325	COG0181	hydroxymethylbilane synthase activity
EPB57_RS18330	COG3072	Adenylate cyclase
EPB57_RS18335	COG1965	Belongs to the frataxin family
EPB57_RS18345	COG0019	diaminopimelate decarboxylase activity
EPB57_RS18360	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
EPB57_RS18365	COG1011	Hydrolase
EPB57_RS18370	COG3287	FIST C domain
EPB57_RS18370	COG2199	diguanylate cyclase activity
EPB57_RS18370	COG2200	EAL domain
EPB57_RS18375	COG3148	PFAM DTW domain containing protein
EPB57_RS18390	COG0561	phosphatase activity
EPB57_RS18395	COG2267	carboxylic ester hydrolase activity
EPB57_RS18400	COG1280	lysine exporter protein (LysE YggA)
EPB57_RS18405	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
EPB57_RS18410	COG0640	Transcriptional regulator
EPB57_RS18415	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EPB57_RS18465	COG2095	MarC family integral membrane protein
EPB57_RS18475	COG0742	ribosomal rna small subunit methyltransferase
EPB57_RS18480	COG0552	protein localization to endoplasmic reticulum
EPB57_RS18485	COG2884	Cell division ATP-binding protein ftsE
EPB57_RS18490	COG2177	Part of the ABC transporter FtsEX involved in
EPB57_RS18500	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EPB57_RS18505	COG0705	Rhomboid family
EPB57_RS18510	COG1580	Controls the rotational direction of flagella during chemotaxis
EPB57_RS18515	COG3161	chorismate lyase activity
EPB57_RS18520	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EPB57_RS18525	COG2937	Belongs to the GPAT DAPAT family
EPB57_RS18530	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EPB57_RS18535	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
EPB57_RS18540	COG0534	Mate efflux family protein
EPB57_RS18545	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EPB57_RS18565	COG4206	TonB-dependent receptor
EPB57_RS18630	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EPB57_RS18640	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EPB57_RS18645	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
EPB57_RS18645	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
EPB57_RS18675	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EPB57_RS18685	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EPB57_RS18690	COG0250	Participates in transcription elongation, termination and antitermination
EPB57_RS18705	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EPB57_RS18710	COG0222	ribosome binding
EPB57_RS18715	COG0085	RNA polymerase activity
EPB57_RS18720	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EPB57_RS18725	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
EPB57_RS18730	COG2816	NAD+ diphosphatase activity
EPB57_RS18735	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EPB57_RS18740	COG1573	uracil-dna glycosylase
EPB57_RS18750	COG3068	Protein conserved in bacteria
EPB57_RS18755	COG1253	flavin adenine dinucleotide binding
EPB57_RS18770	COG0151	Belongs to the GarS family
EPB57_RS18785	COG0789	Transcriptional regulator
EPB57_RS18790	COG3710	Transcriptional regulator
EPB57_RS18800	COG0531	amino acid
EPB57_RS18805	COG1982	Orn Lys Arg decarboxylase major
EPB57_RS18830	COG0488	(ABC) transporter
EPB57_RS18840	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
EPB57_RS18845	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EPB57_RS18850	COG2264	protein methyltransferase activity
EPB57_RS18860	COG0439	Biotin carboxylase
EPB57_RS18865	COG0511	ligase activity, forming carbon-carbon bonds
EPB57_RS18870	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EPB57_RS18875	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EPB57_RS18890	COG2814	Major facilitator Superfamily
EPB57_RS18915	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EPB57_RS18925	COG3263	regulation of cellular component size
EPB57_RS18935	COG4232	protein-disulfide reductase activity
EPB57_RS18940	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EPB57_RS18945	COG1027	Aspartate ammonia-lyase
EPB57_RS18950	COG3030	protein affecting phage T7 exclusion by the F plasmid
EPB57_RS18955	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EPB57_RS18965	COG2205	protein histidine kinase activity
EPB57_RS18970	COG0745	RESPONSE REGULATOR receiver
EPB57_RS18975	COG3678	ATP-independent chaperone mediated protein folding
EPB57_RS18985	COG0205	6-phosphofructokinase activity
EPB57_RS18990	COG0534	Mate efflux family protein
EPB57_RS19000	COG0459	protein refolding
EPB57_RS19010	COG1285	pathogenesis
EPB57_RS19015	COG1509	lysine 2,3-aminomutase activity
EPB57_RS19030	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
EPB57_RS19035	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
EPB57_RS19040	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EPB57_RS19045	COG1053	succinate dehydrogenase
EPB57_RS19050	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
EPB57_RS19070	COG4942	peptidase
EPB57_RS19075	COG1045	serine acetyltransferase
EPB57_RS19080	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EPB57_RS19085	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
EPB57_RS19090	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EPB57_RS19095	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
EPB57_RS19105	COG0471	metal ion transport
EPB57_RS19110	COG0688	phosphatidylethanolamine metabolic process
EPB57_RS19115	COG1162	GTPase activity
EPB57_RS19120	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
EPB57_RS19185	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EPB57_RS19190	COG0802	atpase or kinase
EPB57_RS19200	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EPB57_RS19205	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EPB57_RS19215	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EPB57_RS19220	COG0330	HflC and HflK could
EPB57_RS19225	COG0330	HflC and HflK could
EPB57_RS19230	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
EPB57_RS19235	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EPB57_RS19245	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
EPB57_RS19250	COG1017	nitric oxide dioxygenase activity
EPB57_RS19250	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EPB57_RS19255	COG1959	2 iron, 2 sulfur cluster binding
EPB57_RS19260	COG0557	exoribonuclease II activity
EPB57_RS19265	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EPB57_RS19270	COG0546	phosphoglycolate phosphatase activity
EPB57_RS19275	COG0180	Tryptophanyl-tRNA synthetase
EPB57_RS19290	COG0512	Glutamine amidotransferase of anthranilate synthase
EPB57_RS19295	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EPB57_RS19315	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EPB57_RS19320	COG3954	Phosphoribulokinase
EPB57_RS19330	COG0429	hydrolase of the alpha beta-hydrolase fold
EPB57_RS19340	COG0488	(ABC) transporter
EPB57_RS19345	COG2249	NAD(P)H dehydrogenase (quinone) activity
EPB57_RS19360	COG1047	Peptidyl-prolyl cis-trans
EPB57_RS19370	COG1446	asparaginase
EPB57_RS19385	COG0545	Peptidyl-prolyl cis-trans isomerase
EPB57_RS19390	COG2964	Protein conserved in bacteria
EPB57_RS19395	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
EPB57_RS19400	COG2923	Belongs to the DsrF TusC family
EPB57_RS19420	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EPB57_RS19425	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EPB57_RS19440	COG0281	malic enzyme
EPB57_RS19445	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
EPB57_RS19450	COG0626	cystathionine gamma-synthase activity
EPB57_RS19455	COG0527	aspartate kinase activity
EPB57_RS19455	COG0460	homoserine dehydrogenase
EPB57_RS19460	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EPB57_RS19470	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
EPB57_RS19480	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EPB57_RS19490	COG0137	argininosuccinate synthase activity
EPB57_RS19495	COG0165	Argininosuccinate lyase
EPB57_RS19495	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
EPB57_RS19505	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EPB57_RS19510	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EPB57_RS19510	COG0678	peroxiredoxin activity
EPB57_RS19520	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EPB57_RS19550	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EPB57_RS19555	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EPB57_RS19565	COG0338	D12 class N6 adenine-specific DNA methyltransferase
EPB57_RS19570	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EPB57_RS19575	COG0360	Binds together with S18 to 16S ribosomal RNA
EPB57_RS19580	COG2965	DNA replication, synthesis of RNA primer
EPB57_RS19610	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EPB57_RS19615	COG0432	Pfam Uncharacterised protein family UPF0047
EPB57_RS19620	COG0166	Belongs to the GPI family
EPB57_RS19630	COG0735	belongs to the Fur family
EPB57_RS19635	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EPB57_RS19655	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EPB57_RS19660	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EPB57_RS19665	COG0175	sulfate reduction
EPB57_RS19725	COG0646	methionine synthase
EPB57_RS19725	COG1410	methionine synthase
EPB57_RS19730	COG0527	aspartate kinase activity
EPB57_RS19735	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EPB57_RS19745	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EPB57_RS19760	COG0629	single-stranded DNA binding
EPB57_RS19770	COG2200	EAL domain
EPB57_RS19770	COG2199	diguanylate cyclase activity
EPB57_RS19790	COG1450	Type ii and iii secretion system protein
EPB57_RS19795	COG3409	Peptidoglycan-binding domain 1 protein
EPB57_RS19795	COG3267	Type II secretory pathway component ExeA
EPB57_RS19805	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EPB57_RS19810	COG1459	type II secretion system
EPB57_RS19855	COG1077	Cell shape determining protein MreB Mrl
EPB57_RS19860	COG1792	Involved in formation and maintenance of cell shape
EPB57_RS19865	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
EPB57_RS19870	COG0424	maF-like protein
EPB57_RS19880	COG3164	Protein of unknown function
EPB57_RS19885	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EPB57_RS19890	COG0312	modulator of DNA gyrase
EPB57_RS19895	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
EPB57_RS19900	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EPB57_RS19910	COG0564	pseudouridine synthase activity
EPB57_RS19915	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EPB57_RS19920	COG3028	Belongs to the UPF0307 family
EPB57_RS19925	COG0312	modulator of DNA gyrase
EPB57_RS19930	COG2239	Acts as a magnesium transporter
EPB57_RS19935	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EPB57_RS19940	COG1660	Displays ATPase and GTPase activities
EPB57_RS19945	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EPB57_RS19950	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EPB57_RS19960	COG1137	ATPase activity
EPB57_RS19965	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
EPB57_RS19975	COG0517	IMP dehydrogenase activity
EPB57_RS19975	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
EPB57_RS19985	COG1127	ABC transporter
EPB57_RS19990	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EPB57_RS19995	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EPB57_RS20000	COG2854	intermembrane phospholipid transfer
EPB57_RS20010	COG5007	Belongs to the BolA IbaG family
EPB57_RS20015	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EPB57_RS20020	COG0204	Acyl-transferase
EPB57_RS20025	COG0251	oxidation-reduction process
EPB57_RS20030	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
EPB57_RS20035	COG0540	Belongs to the ATCase OTCase family
EPB57_RS20065	COG0456	acetyltransferase
EPB57_RS20075	COG0525	valine-tRNA ligase activity
EPB57_RS20080	COG2927	DNA polymerase III (CHI subunit)
EPB57_RS20085	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EPB57_RS20090	COG0795	lipopolysaccharide-transporting ATPase activity
EPB57_RS20095	COG0795	lipopolysaccharide-transporting ATPase activity
EPB57_RS20110	COG1028	Short-chain dehydrogenase reductase Sdr
EPB57_RS20120	COG0726	polysaccharide deacetylase
EPB57_RS20125	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EPB57_RS20130	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EPB57_RS20135	COG1447	Phosphotransferase system cellobiose-specific component IIA
EPB57_RS20140	COG1486	melibiose metabolic process
EPB57_RS20145	COG3394	polysaccharide catabolic process
EPB57_RS20150	COG1609	Transcriptional regulator
EPB57_RS20155	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
EPB57_RS20235	COG0840	transmembrane signaling receptor activity
EPB57_RS20280	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
EPB57_RS20290	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EPB57_RS20300	COG2066	Belongs to the glutaminase family
EPB57_RS20305	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EPB57_RS20310	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EPB57_RS20320	COG1872	DUF167
EPB57_RS20325	COG0762	integral membrane protein
EPB57_RS20330	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EPB57_RS20335	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EPB57_RS20350	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EPB57_RS20355	COG1678	Uncharacterized ACR, COG1678
EPB57_RS20360	COG0189	ligase activity
EPB57_RS20365	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EPB57_RS20370	COG2356	endonuclease I
EPB57_RS20385	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EPB57_RS20395	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EPB57_RS20400	COG0583	DNA-binding transcription factor activity
EPB57_RS20405	COG4771	TonB-dependent receptor
EPB57_RS20420	COG0191	fructose-bisphosphate aldolase activity
EPB57_RS20425	COG0668	transmembrane transport
EPB57_RS20440	COG0583	DNA-binding transcription factor activity
EPB57_RS20450	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EPB57_RS20455	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EPB57_RS20460	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EPB57_RS20470	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
EPB57_RS20480	COG3079	Belongs to the UPF0149 family
EPB57_RS20485	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EPB57_RS20490	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EPB57_RS20510	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
EPB57_RS20520	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EPB57_RS20530	COG1595	DNA-templated transcription, initiation
EPB57_RS20545	COG3086	response to oxidative stress
EPB57_RS20550	COG0481	GTPase activity
EPB57_RS20555	COG0681	Belongs to the peptidase S26 family
EPB57_RS20565	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EPB57_RS20570	COG1381	Involved in DNA repair and RecF pathway recombination
EPB57_RS20575	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
EPB57_RS20580	COG0736	holo-[acyl-carrier-protein] synthase activity
EPB57_RS20595	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EPB57_RS20605	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EPB57_RS20610	COG3956	TIGRFAM MazG family protein
EPB57_RS20615	COG0504	CTP synthase activity
EPB57_RS20620	COG0148	phosphopyruvate hydratase activity
EPB57_RS20625	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
EPB57_RS20630	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EPB57_RS20635	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
EPB57_RS20645	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
EPB57_RS20650	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EPB57_RS20660	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EPB57_RS20665	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EPB57_RS20670	COG1546	Belongs to the CinA family
EPB57_RS20675	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EPB57_RS20685	COG2137	regulation of response to DNA damage stimulus
EPB57_RS20690	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EPB57_RS20695	COG0527	aspartate kinase activity
EPB57_RS20760	COG3630	sodium ion export across plasma membrane
EPB57_RS20765	COG5016	pyruvate
EPB57_RS20765	COG0511	ligase activity, forming carbon-carbon bonds
EPB57_RS20770	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
EPB57_RS20780	COG1238	metal cluster binding
EPB57_RS20785	COG0612	Peptidase, M16
EPB57_RS20800	COG1854	S-ribosylhomocysteine lyase activity
EPB57_RS20805	COG4536	flavin adenine dinucleotide binding
EPB57_RS20810	COG4137	Cytochrome C assembly protein
EPB57_RS20815	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EPB57_RS20820	COG0228	four-way junction DNA binding
EPB57_RS20825	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EPB57_RS20840	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
EPB57_RS20845	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
EPB57_RS20850	COG0237	dephospho-CoA kinase activity
EPB57_RS20860	COG1459	type II secretion system
EPB57_RS20865	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EPB57_RS20875	COG0157	Belongs to the NadC ModD family
EPB57_RS20885	COG2186	Transcriptional regulator
EPB57_RS20890	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
EPB57_RS20895	COG0508	dehydrogenase complex catalyzes the overall conversion of
EPB57_RS20900	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EPB57_RS20915	COG0288	reversible hydration of carbon dioxide
EPB57_RS20920	COG0659	secondary active sulfate transmembrane transporter activity
EPB57_RS20925	COG1131	(ABC) transporter
EPB57_RS20930	COG0842	Transport permease protein
EPB57_RS20935	COG1560	Kdo2-lipid A biosynthetic process
EPB57_RS20940	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EPB57_RS20945	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EPB57_RS20950	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EPB57_RS20960	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EPB57_RS20970	COG1489	DNA binding
EPB57_RS20975	COG1643	Atp-dependent helicase
EPB57_RS20980	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EPB57_RS20985	COG1752	Esterase of the alpha-beta hydrolase superfamily
EPB57_RS20990	COG1049	propionate catabolic process, 2-methylcitrate cycle
EPB57_RS20995	COG3112	Uncharacterised protein family (UPF0231)
EPB57_RS21005	COG0004	ammonium transporteR
EPB57_RS21010	COG1840	ABC-type Fe3 transport system, periplasmic component
EPB57_RS21020	COG3842	ATPase activity
EPB57_RS21025	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EPB57_RS21040	COG2971	BadF BadG BcrA BcrD
EPB57_RS21050	COG4608	Belongs to the ABC transporter superfamily
EPB57_RS21055	COG0444	Belongs to the ABC transporter superfamily
EPB57_RS21060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EPB57_RS21070	COG0747	negative chemotaxis
EPB57_RS21075	COG0784	Response regulator, receiver
EPB57_RS21075	COG2205	protein histidine kinase activity
EPB57_RS21085	COG0628	permease
EPB57_RS21110	COG0739	heme binding
EPB57_RS21115	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EPB57_RS21125	COG2027	D-alanyl-D-alanine carboxypeptidase
EPB57_RS21130	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EPB57_RS21135	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EPB57_RS21140	COG1534	Rna-binding protein
EPB57_RS21145	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
EPB57_RS21150	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EPB57_RS21155	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EPB57_RS21160	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EPB57_RS21170	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EPB57_RS21185	COG0779	Required for maturation of 30S ribosomal subunits
EPB57_RS21190	COG0195	Participates in both transcription termination and antitermination
EPB57_RS21195	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EPB57_RS21200	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EPB57_RS21205	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EPB57_RS21210	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EPB57_RS21215	COG1185	polyribonucleotide nucleotidyltransferase activity
EPB57_RS21230	COG0534	Mate efflux family protein
EPB57_RS21235	COG0826	peptidase U32
EPB57_RS21240	COG0826	peptidase U32
EPB57_RS21250	COG3154	lipid carrier protein
EPB57_RS21255	COG3153	acetyltransferase
EPB57_RS21285	COG0084	hydrolase, TatD family'
EPB57_RS21290	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EPB57_RS21295	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EPB57_RS21300	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
EPB57_RS21305	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
EPB57_RS21310	COG0813	purine-nucleoside phosphorylase activity
EPB57_RS21320	COG0560	Phosphoserine phosphatase
EPB57_RS21330	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EPB57_RS21335	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EPB57_RS21340	COG0583	DNA-binding transcription factor activity
EPB57_RS21350	COG1022	Amp-dependent synthetase and ligase
EPB57_RS21355	COG2169	Transcriptional regulator
EPB57_RS21380	COG4964	Belongs to the GSP D family
EPB57_RS21440	COG0583	DNA-binding transcription factor activity
EPB57_RS21445	COG1609	Transcriptional regulator
EPB57_RS21465	COG0598	Magnesium transport protein CorA
EPB57_RS21470	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EPB57_RS21475	COG1349	DNA-binding transcription factor activity
EPB57_RS21480	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EPB57_RS21485	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EPB57_RS21495	COG2271	Major facilitator Superfamily
EPB57_RS21500	COG0584	glycerophosphoryl diester phosphodiesterase
EPB57_RS21505	COG2171	N-acyltransferase activity
EPB57_RS21520	COG3141	response to X-ray
EPB57_RS21540	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
EPB57_RS21545	COG1074	ATP-dependent DNA helicase activity
EPB57_RS21550	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EPB57_RS21570	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
EPB57_RS21570	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EPB57_RS21580	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
EPB57_RS21585	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EPB57_RS21590	COG2166	iron-sulfur cluster assembly
EPB57_RS21595	COG3706	GGDEF domain
EPB57_RS21600	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EPB57_RS21605	COG0693	protein deglycase activity
EPB57_RS21610	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EPB57_RS21635	COG1595	DNA-templated transcription, initiation
EPB57_RS21655	COG3056	Lipoprotein
EPB57_RS21660	COG2813	Specifically methylates the guanine in position
EPB57_RS21665	COG0271	Belongs to the BolA IbaG family
EPB57_RS21670	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EPB57_RS21675	COG1805	sodium ion transport
EPB57_RS21680	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EPB57_RS21685	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EPB57_RS21690	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EPB57_RS21695	COG2871	sodium ion transport
EPB57_RS21700	COG1477	protein flavinylation
EPB57_RS21720	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EPB57_RS21725	COG0514	ATP-dependent DNA helicase (RecQ)
EPB57_RS21745	COG0733	neurotransmitter:sodium symporter activity
EPB57_RS21765	COG0442	prolyl-tRNA aminoacylation
EPB57_RS21770	COG1720	tRNA m6t6A37 methyltransferase activity
EPB57_RS21775	COG0254	rRNA binding
EPB57_RS21785	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
EPB57_RS21810	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EPB57_RS21815	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EPB57_RS21850	COG0564	pseudouridine synthase activity
EPB57_RS21860	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
EPB57_RS21865	COG0024	Methionine aminopeptidase
EPB57_RS21870	COG0052	Belongs to the universal ribosomal protein uS2 family
EPB57_RS21875	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EPB57_RS21880	COG0528	UMP kinase activity
EPB57_RS21885	COG0233	cytoplasmic translational termination
EPB57_RS21890	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EPB57_RS21895	COG0575	Belongs to the CDS family
EPB57_RS21900	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
EPB57_RS21905	COG0750	zinc metalloprotease
EPB57_RS21915	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
EPB57_RS21920	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EPB57_RS21930	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EPB57_RS21935	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EPB57_RS21945	COG0587	DNA-directed DNA polymerase activity
EPB57_RS21950	COG0825	malonyl-CoA metabolic process
EPB57_RS21965	COG0347	Belongs to the P(II) protein family
EPB57_RS21970	COG3021	interspecies interaction between organisms
EPB57_RS21980	COG1388	LysM domain
EPB57_RS21980	COG0741	lytic transglycosylase activity
EPB57_RS21985	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EPB57_RS21990	COG2226	methyltransferase
EPB57_RS21995	COG0328	RNA-DNA hybrid ribonuclease activity
EPB57_RS22030	COG1960	acyl-CoA dehydrogenase activity
EPB57_RS22035	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EPB57_RS22040	COG0121	glutamine amidotransferase
EPB57_RS22045	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EPB57_RS22050	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EPB57_RS22055	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
EPB57_RS22060	COG2233	PERMEase
EPB57_RS22080	COG4783	chaperone-mediated protein folding
EPB57_RS22095	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EPB57_RS22105	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EPB57_RS22110	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
EPB57_RS22125	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EPB57_RS22130	COG1393	Belongs to the ArsC family
EPB57_RS22155	COG2837	iron assimilation
EPB57_RS22160	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EPB57_RS22170	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EPB57_RS22175	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EPB57_RS22180	COG1334	flagellar protein FlaG
EPB57_RS22185	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
EPB57_RS22195	COG1516	flagellar protein fliS
EPB57_RS22215	COG1677	Flagellar hook-basal body complex protein FliE
EPB57_RS22225	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EPB57_RS22280	COG1987	bacterial-type flagellum assembly
EPB57_RS22320	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
EPB57_RS22325	COG0784	Response regulator, receiver
EPB57_RS22325	COG0643	Histidine kinase
EPB57_RS22325	COG2198	Histidine kinase
EPB57_RS22330	COG2201	protein-glutamate methylesterase activity
EPB57_RS22335	COG1192	Involved in chromosome partitioning
EPB57_RS22345	COG0835	chemotaxis
EPB57_RS22355	COG4133	protoheme IX ABC transporter activity
EPB57_RS22360	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EPB57_RS22365	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EPB57_RS22370	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EPB57_RS22375	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
EPB57_RS22380	COG1138	Cytochrome C-type biogenesis protein
EPB57_RS22385	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EPB57_RS22395	COG4235	cytochrome complex assembly
EPB57_RS22395	COG3088	subunit of a heme lyase
EPB57_RS22405	COG2067	long-chain fatty acid transport protein
EPB57_RS22425	COG0183	Belongs to the thiolase family
EPB57_RS22430	COG1024	Enoyl-CoA hydratase
EPB57_RS22430	COG1250	3-hydroxyacyl-CoA dehydrogenase
EPB57_RS22445	COG2062	phosphohistidine phosphatase, SixA
EPB57_RS22450	COG2840	Smr protein MutS2
EPB57_RS22455	COG2890	protein-(glutamine-N5) methyltransferase activity
EPB57_RS22460	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EPB57_RS22465	COG2860	membrane
EPB57_RS22475	COG3101	peptidyl-lysine hydroxylation
EPB57_RS22490	COG0431	NADPH-dependent FMN reductase
EPB57_RS22495	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EPB57_RS22495	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
EPB57_RS22500	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EPB57_RS22505	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EPB57_RS22510	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EPB57_RS22520	COG0101	tRNA pseudouridine synthase activity
EPB57_RS22525	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EPB57_RS22530	COG0285	dihydrofolate synthase activity
EPB57_RS22535	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
EPB57_RS22540	COG1286	toxin biosynthetic process
EPB57_RS22545	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EPB57_RS22550	COG0583	DNA-binding transcription factor activity
EPB57_RS22555	COG0745	RESPONSE REGULATOR receiver
EPB57_RS22565	COG2832	Protein of unknown function (DUF454)
EPB57_RS22570	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EPB57_RS22585	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EPB57_RS22590	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EPB57_RS22600	COG2261	transglycosylase associated protein
EPB57_RS22605	COG2983	Belongs to the UPF0260 family
EPB57_RS22610	COG0668	transmembrane transport
EPB57_RS22615	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
EPB57_RS22620	COG0346	lactoylglutathione lyase activity
EPB57_RS22630	COG1785	Belongs to the alkaline phosphatase family
EPB57_RS22650	COG2226	methyltransferase
EPB57_RS22665	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EPB57_RS22670	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EPB57_RS22680	COG3139	Protein of unknown function (DUF1315)
EPB57_RS22685	COG0252	asparaginase activity
EPB57_RS22690	COG0616	signal peptide processing
EPB57_RS22695	COG1902	pentaerythritol trinitrate reductase activity
EPB57_RS22695	COG0446	pyridine nucleotide-disulphide oxidoreductase
EPB57_RS22705	COG0778	Nitroreductase
EPB57_RS22710	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EPB57_RS22725	COG0123	including yeast histone deacetylase and acetoin utilization protein
EPB57_RS22740	COG3082	Protein of unknown function (DUF1414)
EPB57_RS22745	COG3081	Nucleoid-associated protein
EPB57_RS22760	COG1757	Na H antiporter
EPB57_RS22765	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EPB57_RS22770	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EPB57_RS22775	COG2095	MarC family integral membrane protein
EPB57_RS22780	COG1454	alcohol dehydrogenase
EPB57_RS22780	COG1012	belongs to the aldehyde dehydrogenase family
EPB57_RS22800	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EPB57_RS22805	COG4974	Belongs to the 'phage' integrase family
EPB57_RS22815	COG1401	restriction endodeoxyribonuclease activity
EPB57_RS22875	COG4695	Portal protein
EPB57_RS23010	COG2056	Na+-H+ antiporter family
EPB57_RS23015	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EPB57_RS23025	COG2885	chlorophyll binding
EPB57_RS23035	COG0346	lactoylglutathione lyase activity
EPB57_RS23040	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EPB57_RS23045	COG4660	Part of a membrane complex involved in electron transport
EPB57_RS23050	COG4659	FMN binding
EPB57_RS23055	COG4658	electron transport chain
EPB57_RS23060	COG4656	Part of a membrane complex involved in electron transport
EPB57_RS23065	COG2878	Part of a membrane complex involved in electron transport
EPB57_RS23070	COG4657	Part of a membrane complex involved in electron transport
EPB57_RS23075	COG1882	Formate acetyltransferase
EPB57_RS23085	COG0556	nucleotide-excision repair
EPB57_RS23090	COG2204	response regulator
EPB57_RS23095	COG2198	Histidine kinase
EPB57_RS23100	COG0391	Required for morphogenesis under gluconeogenic growth conditions
EPB57_RS23105	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EPB57_RS23110	COG0521	Mo-molybdopterin cofactor biosynthetic process
EPB57_RS23115	COG0315	cyclic pyranopterin monophosphate synthase activity
EPB57_RS23120	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
EPB57_RS23125	COG0314	molybdopterin synthase activity
EPB57_RS23135	COG0601	transmembrane transport
EPB57_RS23140	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EPB57_RS23145	COG0444	Belongs to the ABC transporter superfamily
EPB57_RS23155	COG0435	Glutathione S-transferase
EPB57_RS23165	COG0280	phosphate acetyltransferase
EPB57_RS23165	COG0857	belongs to the CobB CobQ family
EPB57_RS23170	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EPB57_RS23175	COG3092	negative regulation of chromosome organization
EPB57_RS23185	COG4120	Belongs to the binding-protein-dependent transport system permease family
EPB57_RS23190	COG1122	ATPase activity
EPB57_RS23195	COG0366	Alpha amylase catalytic
EPB57_RS23200	COG3706	GGDEF domain
EPB57_RS23205	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EPB57_RS23210	COG3012	SEC-C Motif Domain Protein
EPB57_RS23210	COG3318	Belongs to the UPF0149 family
EPB57_RS23215	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
EPB57_RS23220	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EPB57_RS23225	COG2186	Transcriptional regulator
EPB57_RS23235	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EPB57_RS23235	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EPB57_RS23245	COG0572	uridine kinase
EPB57_RS23255	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
EPB57_RS23260	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EPB57_RS23270	COG0659	secondary active sulfate transmembrane transporter activity
EPB57_RS23275	COG1530	ribonuclease E activity
EPB57_RS23280	COG0564	pseudouridine synthase activity
EPB57_RS23285	COG0424	maF-like protein
EPB57_RS23290	COG1399	metal-binding, possibly nucleic acid-binding protein
EPB57_RS23300	COG0416	fatty acid biosynthetic process
EPB57_RS23305	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EPB57_RS23335	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EPB57_RS23340	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EPB57_RS23345	COG0470	DNA polymerase III
EPB57_RS23350	COG0084	hydrolase, TatD family'
EPB57_RS23355	COG1263	PTS System
EPB57_RS23355	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EPB57_RS23370	COG0733	neurotransmitter:sodium symporter activity
EPB57_RS23385	COG4667	esterase of the alpha-beta hydrolase superfamily
EPB57_RS23390	COG0469	pyruvate kinase activity
EPB57_RS23395	COG1940	carbohydrate kinase activity
EPB57_RS23400	COG0784	Response regulator, receiver
EPB57_RS23400	COG0835	chemotaxis
EPB57_RS23405	COG0587	DNA-directed DNA polymerase activity
EPB57_RS23420	COG1028	Short-chain dehydrogenase reductase Sdr
EPB57_RS23425	COG0616	signal peptide processing
EPB57_RS23430	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EPB57_RS23435	COG0539	negative regulation of cytoplasmic translation
EPB57_RS23445	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
EPB57_RS23450	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
EPB57_RS23460	COG4166	transmembrane transport
EPB57_RS23480	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EPB57_RS23480	COG3008	intermembrane lipid transfer
EPB57_RS23485	COG2995	paraquat-inducible protein a
EPB57_RS23490	COG3258	Cytochrome c
EPB57_RS23495	COG2863	cytochrome
EPB57_RS23530	COG4232	protein-disulfide reductase activity
EPB57_RS23535	COG3118	belongs to the thioredoxin family
EPB57_RS23555	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EPB57_RS23565	COG1136	(ABC) transporter
EPB57_RS23565	COG0577	efflux transmembrane transporter activity
EPB57_RS23570	COG0577	efflux transmembrane transporter activity
EPB57_RS23570	COG1136	(ABC) transporter
EPB57_RS23575	COG1136	(ABC) transporter
EPB57_RS23575	COG0577	efflux transmembrane transporter activity
EPB57_RS23625	COG5002	protein histidine kinase activity
EPB57_RS23625	COG3850	Histidine kinase
EPB57_RS23630	COG0745	RESPONSE REGULATOR receiver
EPB57_RS23635	COG0463	Glycosyl transferase, family 2
EPB57_RS23640	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
EPB57_RS23660	COG1032	radical SAM domain protein
EPB57_RS23665	COG5001	Diguanylate cyclase
EPB57_RS23680	COG0583	DNA-binding transcription factor activity
EPB57_RS23685	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EPB57_RS23695	COG2350	Protein conserved in bacteria
EPB57_RS23705	COG2917	probably involved in intracellular septation
EPB57_RS23725	COG1301	dicarboxylic acid transport
EPB57_RS23730	COG0318	PFAM AMP-dependent synthetase and ligase
EPB57_RS23735	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EPB57_RS23740	COG0159	tryptophan synthase activity
EPB57_RS23750	COG0135	phosphoribosylanthranilate isomerase activity
EPB57_RS23750	COG0134	indole-3-glycerol-phosphate synthase activity
EPB57_RS23760	COG0512	Glutamine amidotransferase of anthranilate synthase
EPB57_RS23765	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EPB57_RS23775	COG0613	PHP domain protein
EPB57_RS23780	COG0009	L-threonylcarbamoyladenylate synthase