locus-tag class description GPY59_RS00005 ENOG4107RE1 Inosine-guanosine kinase GPY59_RS00020 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) GPY59_RS00025 ENOG4108N3W hemolysin secretion protein GPY59_RS00035 ENOG4108ZYK Acyl carrier protein phosphodiesterase GPY59_RS00040 ENOG4105C1J atp-dependent rna helicase GPY59_RS00060 ENOG4105DS1 cytochrome b561 GPY59_RS00065 ENOG4108YYC ycei family GPY59_RS00070 ENOG4105TMB Formate nitrite transporter GPY59_RS00075 ENOG4105DUM transcriptional regulator, lysR family GPY59_RS00080 ENOG4108UQ5 membrane protein YcdZ GPY59_RS00085 ENOG4105CPB ATP-dependent endonuclease of the OLD family GPY59_RS00090 ENOG4105CGH 5'-nucleotidase GPY59_RS00095 ENOG4105DU1 integral membrane protein, terc GPY59_RS00115 ENOG4108M0H Extracellular lipase GPY59_RS00120 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation GPY59_RS00135 ENOG4105KA0 thioesterase Superfamily protein GPY59_RS00145 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) GPY59_RS00180 ENOG4105BZU Histidine kinase GPY59_RS00185 ENOG4105RKW reductase (By GPY59_RS00195 ENOG4108I0Y (ABC) transporter GPY59_RS00200 ENOG4105CV6 ABC transporter, permease GPY59_RS00210 ENOG4107R7A Allophanate hydrolase subunit 2 GPY59_RS00215 ENOG4105P4J Allophanate hydrolase, subunit 1 GPY59_RS00220 ENOG4105E7W lamb ycsf family protein GPY59_RS00225 ENOG4105BZU Histidine kinase GPY59_RS00230 ENOG4105CMR udp-glucose 4-epimerase GPY59_RS00245 ENOG4105CWB LysR family transcriptional Regulator GPY59_RS00250 ENOG4105CD5 CoA-binding domain protein GPY59_RS00260 ENOG4105CPF Cell wall formation (By similarity) GPY59_RS00270 ENOG4108ZJT translation initiation factor, Sui1 GPY59_RS00380 ENOG4105VZ1 Replication Protein GPY59_RS00430 ENOG4105EJC lysr family transcriptional regulator GPY59_RS00440 ENOG4108M6U Universal stress protein A GPY59_RS00470 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) GPY59_RS00475 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) GPY59_RS00490 ENOG4105BZU Histidine kinase GPY59_RS00505 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) GPY59_RS00510 ENOG4105E0C molybdate abc transporter GPY59_RS00515 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein GPY59_RS00520 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) GPY59_RS00525 ENOG4105WXI Bacterial OB fold (BOF) protein GPY59_RS00535 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) GPY59_RS00540 ENOG4105CGF Aromatic amino acid aminotransferase GPY59_RS00545 ENOG4108K01 transcriptional regulator GPY59_RS00550 ENOG4105UQX Mate efflux family protein GPY59_RS00555 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) GPY59_RS00560 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase GPY59_RS00595 ENOG4107TIF Phenazine biosynthesis protein, PhzF family GPY59_RS00610 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit GPY59_RS00620 ENOG4105C5Q Transcriptional regulator GPY59_RS00625 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) GPY59_RS00630 ENOG4105CXY transporter GPY59_RS00635 ENOG4108KX4 response regulator GPY59_RS00640 ENOG4105BZU Histidine kinase GPY59_RS00645 ENOG4105CXY transporter GPY59_RS00650 ENOG4105EIP mannose-6-phosphate isomerase GPY59_RS00670 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GPY59_RS00675 ENOG4105K63 Thioredoxin GPY59_RS00680 ENOG4108ISG Major Facilitator GPY59_RS00685 ENOG4105VXR cytoplasmic protein GPY59_RS00690 ENOG4105KNA -acetyltransferase GPY59_RS00710 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter GPY59_RS00725 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GPY59_RS00730 ENOG4105TMB Formate nitrite transporter GPY59_RS00735 ENOG4105WZK nitrite reductase NADPH small subunit GPY59_RS00740 ENOG4107QZF nitrite reductase NADPH large subunit GPY59_RS00745 ENOG4105NXH GreA GreB family elongation factor GPY59_RS00750 ENOG4105BZU Histidine kinase GPY59_RS00760 ENOG4105BZU Histidine kinase GPY59_RS00765 ENOG4105DEN Luciferase family GPY59_RS00810 ENOG4108NVR Methyl-accepting chemotaxis GPY59_RS00815 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) GPY59_RS00830 ENOG4105CXG d-lactate dehydrogenase GPY59_RS00835 ENOG4105CC0 LysR family Transcriptional regulator GPY59_RS00850 ENOG4105EV2 VWA domain protein interacting with AAA ATPase GPY59_RS00855 ENOG4107R4Q Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone (By similarity) GPY59_RS00865 ENOG4105C5W Aldolase GPY59_RS00875 ENOG4105CSX c4-dicarboxylate anaerobic carrier GPY59_RS00885 ENOG4105QNF Outer membrane lipoprotein GPY59_RS00895 ENOG4105EYH Exonuclease GPY59_RS00900 ENOG4107RFY SbcCD D subunit GPY59_RS00925 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GPY59_RS00970 ENOG4108ZF3 Phosphatase GPY59_RS00985 ENOG4106VK6 Flagellar motor protein GPY59_RS01005 ENOG4105D9P serine threonine protein kinase GPY59_RS01025 ENOG4105F8J Adenylate Guanylate cyclase GPY59_RS01055 ENOG4107QZF nitrite reductase NADPH large subunit GPY59_RS01060 ENOG4105D7T ABC transporter GPY59_RS01065 ENOG4105DG7 nitrate ABC transporter GPY59_RS01095 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GPY59_RS01110 ENOG4105C44 Serine transporter GPY59_RS01120 ENOG4105BZU Histidine kinase GPY59_RS01175 ENOG4106E5D Protein of unknown function (DUF461) GPY59_RS01180 ENOG4105R8A Heat shock protein GPY59_RS01200 ENOG4107RUY (E1 component), alpha subunit GPY59_RS01210 ENOG4107QSN dihydrolipoamide acetyltransferase GPY59_RS01215 ENOG4105C10 Electron transfer flavoprotein GPY59_RS01220 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase GPY59_RS01225 ENOG4105EXG Transcriptional regulator GPY59_RS01240 ENOG4105DUM transcriptional regulator, lysR family GPY59_RS01250 ENOG4105DMR ABC, transporter GPY59_RS01255 ENOG4105GBT ABC transporter GPY59_RS01260 ENOG4106PMH Extracellular solute-binding protein family 3 GPY59_RS01265 ENOG4105E5Z arginine transporter ATP-binding subunit GPY59_RS01305 ENOG4105C26 Dehydrogenase GPY59_RS01320 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GPY59_RS01325 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) GPY59_RS01335 ENOG4105CCU oxidase (Subunit III) GPY59_RS01340 ENOG4105BZ9 Cytochrome C oxidase, subunit I GPY59_RS01345 ENOG4105E2S oxidase) subunit II GPY59_RS01350 ENOG4105CHR reductase GPY59_RS01355 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase GPY59_RS01360 ENOG4105E39 Enoyl-CoA hydratase GPY59_RS01365 ENOG4105E39 Enoyl-CoA hydratase GPY59_RS01375 ENOG4105C26 Dehydrogenase GPY59_RS01380 ENOG4105CHU acetyl-coa acetyltransferase GPY59_RS01390 ENOG4105C1G acyl-Coa dehydrogenase GPY59_RS01395 ENOG4107QX3 carboxylase GPY59_RS01400 ENOG4105E39 Enoyl-CoA hydratase GPY59_RS01405 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase GPY59_RS01415 ENOG4107SDU Methyl-accepting chemotaxis GPY59_RS01425 ENOG41076UM multiple antibiotic resistance (MarC)-related protein GPY59_RS01430 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters GPY59_RS01440 ENOG4105CKI cobalamin synthesis protein GPY59_RS01445 ENOG4105DR5 peptidase GPY59_RS01455 ENOG4105CKI cobalamin synthesis protein GPY59_RS01470 ENOG4105MYN Zinc uptake regulation protein GPY59_RS01485 ENOG4105HF0 Membrane GPY59_RS01500 ENOG4105ENX hydrolase GPY59_RS01505 ENOG4105ENX hydrolase GPY59_RS01510 ENOG4105EQ2 LysR family Transcriptional regulator GPY59_RS01515 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) GPY59_RS01530 ENOG4105C1J atp-dependent rna helicase GPY59_RS01535 ENOG4108ENQ Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) GPY59_RS01550 ENOG4105CVA phosphate GPY59_RS01570 ENOG4105DKW ABC transporter GPY59_RS01575 ENOG4105CXC rtn protein GPY59_RS01595 ENOG4105C1J atp-dependent rna helicase GPY59_RS01600 ENOG4105CKI cobalamin synthesis protein GPY59_RS01610 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) GPY59_RS01620 ENOG4105VEQ Cold shock protein GPY59_RS01630 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) GPY59_RS01640 ENOG4105VYA Uncharacterized conserved protein (DUF2132) GPY59_RS01645 ENOG4105C1J atp-dependent rna helicase GPY59_RS01655 ENOG4108HPI phosphatidate Cytidylyltransferase GPY59_RS01680 ENOG4105VRT cytoplasmic protein GPY59_RS01700 ENOG41090A4 Pterin carbinolamine dehydratase GPY59_RS01705 ENOG4105MIR Phenylalanine 4-monooxygenase GPY59_RS01710 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GPY59_RS01715 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) GPY59_RS01735 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain GPY59_RS01740 ENOG4105C0A alcohol dehydrogenase GPY59_RS01755 ENOG4108RMU ferritin dps family protein GPY59_RS01760 ENOG4105C8Q Methyl-accepting chemotaxis GPY59_RS01785 ENOG4108MGY Histidine kinase GPY59_RS01790 ENOG4105DFG type I secretion outer membrane protein GPY59_RS01800 ENOG4105BZ1 (ABC) transporter GPY59_RS01810 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GPY59_RS01815 ENOG4105BZU Histidine kinase GPY59_RS01820 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system GPY59_RS01825 ENOG4105VEQ Cold shock protein GPY59_RS01845 ENOG4105CDV Ompa motb domain protein GPY59_RS01855 ENOG4108V1T peptidylprolyl cis-trans isomerase GPY59_RS01860 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) GPY59_RS01865 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) GPY59_RS01890 ENOG4105FT1 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity) GPY59_RS01935 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase GPY59_RS01950 ENOG4108SXK Transporter Drug Metabolite Exporter family GPY59_RS01955 ENOG4105VW4 glutaredoxin 3 GPY59_RS01970 ENOG4105E5M Multidrug resistance protein D GPY59_RS01975 ENOG4105CR8 Transcriptional regulator GPY59_RS01985 ENOG4105DR5 peptidase GPY59_RS02010 ENOG4105DWD nucleoside recognition domain protein GPY59_RS02015 ENOG4105C8Q Methyl-accepting chemotaxis GPY59_RS02025 ENOG4105E0U tyrosine-specific transport protein GPY59_RS02050 ENOG4107RGM aldo keto reductase GPY59_RS02055 ENOG4105JQN Transcriptional regulator GPY59_RS02095 ENOG4105DAX Pfam:DUF2983 GPY59_RS02120 ENOG4105KVH Transcriptional regulator GPY59_RS02135 ENOG4105D6J arsenicaL-resistance protein GPY59_RS02145 ENOG4108V1U phospholipid-binding protein GPY59_RS02150 ENOG4105JAB phenazine biosynthesis protein, phzf family GPY59_RS02160 ENOG4105CJ1 ABC, transporter GPY59_RS02165 ENOG4107QWP ABC-2 type transporter GPY59_RS02175 ENOG4108IEG Formate dehydrogenase Alpha subunit GPY59_RS02195 ENOG4108IJF Heavy metal efflux pump, CzcA GPY59_RS02220 ENOG4108HK0 -acetyltransferase GPY59_RS02230 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation GPY59_RS02240 ENOG4105ENT Efflux transporter rnd family, mfp subunit GPY59_RS02255 ENOG4105C5H ABC transporter GPY59_RS02260 ENOG4108M6U Universal stress protein A GPY59_RS02265 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein GPY59_RS02270 ENOG4105CKD glutathione-regulated potassium-efflux system protein GPY59_RS02290 ENOG4105VUF Transcriptional regulator GPY59_RS02295 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase GPY59_RS02305 ENOG4105KXC Collagenase GPY59_RS02320 ENOG4105CR8 Transcriptional regulator GPY59_RS02325 ENOG4105C8Q Methyl-accepting chemotaxis GPY59_RS02330 ENOG41061MD high-affinity nickel-transporter GPY59_RS02335 ENOG41090EM Repressor of rcnA expression. Acts by binding specifically to the rcnA promoter in the absence of nickel and cobalt. In the presence of one of these metals, it has a weaker affinity for rcnA promoter GPY59_RS02340 ENOG4105C6Z Gluconate GPY59_RS02345 ENOG4105EXW epimerase dehydratase GPY59_RS02350 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) GPY59_RS02355 ENOG4105FB2 class II Aldolase GPY59_RS02360 ENOG4105G63 Type III effector Hrp-dependent GPY59_RS02365 ENOG4105ZXK Dehydrogenase GPY59_RS02370 ENOG4105MVE transcriptional regulator GPY59_RS02380 ENOG4105DEF Extracellular solute-binding protein, family 5 GPY59_RS02385 ENOG4108JQ7 (ABC) transporter GPY59_RS02390 ENOG4105C3U ABC transporter GPY59_RS02395 ENOG4107R73 Mate efflux family protein GPY59_RS02400 ENOG4105KQ5 peptidylprolyl cis-trans isomerase GPY59_RS02405 ENOG4107R88 Chemotaxis protein (CheV) GPY59_RS02415 ENOG4105PYN Pyridoxamine 5-phosphate oxidase-related GPY59_RS02420 ENOG41090JE Utilization Protein GPY59_RS02425 ENOG4105D4P Coproporphyrinogen iii oxidase GPY59_RS02430 ENOG4105WQ5 TonB family GPY59_RS02435 ENOG41090AP transport protein GPY59_RS02440 ENOG4106GFD transport protein GPY59_RS02450 ENOG4105EHG Permease protein GPY59_RS02455 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) GPY59_RS02495 ENOG4107X4V Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) GPY59_RS02500 ENOG4107RA1 nh(3)-dependent nad( ) synthetase GPY59_RS02505 ENOG4105QVC MOSC domain-containing protein GPY59_RS02505 ENOG4105QVC MOSC domain-containing protein GPY59_RS02520 ENOG4105EKE dihydroorotase GPY59_RS02525 ENOG4105CKW Inner membrane protein yedI GPY59_RS02555 ENOG4105EG2 ABC transporter, permease GPY59_RS02560 ENOG4105D56 permease protein GPY59_RS02565 ENOG4107FKK extracellular solute-binding protein family 1 GPY59_RS02570 ENOG4108IJ9 (ABC) transporter GPY59_RS02575 ENOG4105D3Q Sugar transferase GPY59_RS02590 ENOG4108F2G Chain length determinant protein GPY59_RS02630 ENOG4105V0I UPF0267 protein GPY59_RS02635 ENOG4108WUH Transcriptional regulator, TetR family GPY59_RS02640 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein GPY59_RS02645 ENOG4108RXX maleylacetoacetate isomerase GPY59_RS02650 ENOG4105CH6 catalase GPY59_RS02655 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase GPY59_RS02685 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 GPY59_RS02700 ENOG4105CJP fad dependent oxidoreductase GPY59_RS02705 ENOG4107QZF nitrite reductase NADPH large subunit GPY59_RS02710 ENOG4105C26 Dehydrogenase GPY59_RS02715 ENOG4105DVW rieske (2Fe-2S) GPY59_RS02725 ENOG4105ETT transcriptional Regulator, LysR family GPY59_RS02730 ENOG4105CZN Potassium uptake protein GPY59_RS02740 ENOG4105EEX Two component transcriptional regulator (Winged helix family GPY59_RS02745 ENOG4105BZU Histidine kinase GPY59_RS02750 ENOG4105BZ1 (ABC) transporter GPY59_RS02755 ENOG4105E0K tonB-dependent siderophore receptor GPY59_RS02760 ENOG4105E0A ABC, transporter GPY59_RS02765 ENOG4108HUF Transporter GPY59_RS02770 ENOG4105S6R Iron-hydroxamate transporter permease subunit GPY59_RS02785 ENOG4108JJ6 Type I secretion system ATPase GPY59_RS02795 ENOG41086KC Transcriptional regulator GPY59_RS02800 ENOG41086KC Transcriptional regulator GPY59_RS02810 ENOG4105C8Q Methyl-accepting chemotaxis GPY59_RS02815 ENOG4105C7R Atpase associated with various cellular activities aaa_3 GPY59_RS02850 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) GPY59_RS02855 ENOG4105E2Z phosphate ABC transporter (Permease GPY59_RS02860 ENOG4105C8U phosphate abc transporter GPY59_RS02865 ENOG4107S17 Phosphate-binding protein GPY59_RS02870 ENOG4108NVR Methyl-accepting chemotaxis GPY59_RS02890 ENOG4107ENK receptor GPY59_RS02895 ENOG4105CUG Oligopeptidase b GPY59_RS02900 ENOG4105C1J atp-dependent rna helicase GPY59_RS02910 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein GPY59_RS02915 ENOG4105CVP deoxyribo-dipyrimidine photolyase GPY59_RS02920 ENOG4108XDN Transcriptional regulator GPY59_RS02925 ENOG4107SEY Conserved Protein GPY59_RS02935 ENOG4105D3A purine nucleoside phosphorylase DeoD-type GPY59_RS02950 ENOG4106TD9 Diguanylate cyclase GPY59_RS02955 ENOG4105KK7 inner membrane protein YiaW GPY59_RS02960 ENOG4105EFX secretion protein, HlyD family GPY59_RS02965 ENOG4108V7D UPF0397 protein GPY59_RS02970 ENOG4108JJB ABC transporter GPY59_RS02990 ENOG4105GXZ Ferredoxin-type protein NapH GPY59_RS02995 ENOG4108BGM Quinol dehydrogenase periplasmic component GPY59_RS03000 ENOG4105WCN acetyltransferase GPY59_RS03015 ENOG4105YE1 PilZ domain GPY59_RS03020 ENOG4107QE9 Inherit from COG: Membrane GPY59_RS03030 ENOG4105DAN ATP-dependent protease GPY59_RS03040 ENOG4108JQ5 ABC transporter GPY59_RS03050 ENOG410642W LysR family Transcriptional regulator GPY59_RS03055 ENOG4105DAA L-lactate GPY59_RS03060 ENOG4105DMF Dehydrogenase GPY59_RS03070 ENOG4105D64 Mechanosensitive ion channel GPY59_RS03105 ENOG4105CPQ Dehydrogenase GPY59_RS03110 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) GPY59_RS03115 ENOG4105BZU Histidine kinase GPY59_RS03130 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GPY59_RS03140 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GPY59_RS03160 ENOG4105EXG Transcriptional regulator GPY59_RS03165 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase GPY59_RS03185 ENOG4107SSZ Phosphatase GPY59_RS03215 ENOG4108JIR Flagellum-specific ATP synthase GPY59_RS03225 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) GPY59_RS03230 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) GPY59_RS03240 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GPY59_RS03255 ENOG4105DD5 Flagellar motor switch protein GPY59_RS03260 ENOG4105CN7 Flagellar biosynthetic protein FliP GPY59_RS03265 ENOG4105VS8 Flagellar biosynthetic protein fliq GPY59_RS03270 ENOG4105D19 Role in flagellar biosynthesis (By similarity) GPY59_RS03275 ENOG4105D00 flagellar biosynthetic protein flhB GPY59_RS03290 ENOG4105I03 Flagellin GPY59_RS03300 ENOG410804A Flagellar hook-associated 2 domain-containing protein GPY59_RS03305 ENOG4105MQ3 flagellar protein FliS GPY59_RS03330 ENOG4107RD7 Flagellar Motor Protein, MotA GPY59_RS03335 ENOG4105ER2 Ompa motb domain protein GPY59_RS03350 ENOG4105KWG Pfam:DUF1696 GPY59_RS03370 ENOG4105C6N Formate acetyltransferase GPY59_RS03375 ENOG4105F1A Pyruvate formate-lyase GPY59_RS03380 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) GPY59_RS03395 ENOG4105EB3 Histidine kinase GPY59_RS03400 ENOG4105E3W Two component transcriptional regulator (Winged helix family GPY59_RS03420 ENOG4105CNH Multidrug resistance protein MdtL GPY59_RS03425 ENOG4105G2Y Transcriptional regulator GPY59_RS03465 ENOG4105IPI Membrane GPY59_RS03470 ENOG41068P6 UPF0319 protein GPY59_RS03480 ENOG4105DP0 ferredoxin-NADP reductase GPY59_RS03490 ENOG4105VYA Uncharacterized conserved protein (DUF2132) GPY59_RS03495 ENOG4105ETT transcriptional Regulator, LysR family GPY59_RS03505 ENOG4108RCM Nitroreductase GPY59_RS03510 ENOG4108ZX5 transcriptional regulator GPY59_RS03520 ENOG4105DZ1 carboxypeptidase GPY59_RS03530 ENOG4105C72 UPF0176 protein GPY59_RS03540 ENOG4105CVP deoxyribo-dipyrimidine photolyase GPY59_RS03550 ENOG4108M1A Chitin-binding protein GPY59_RS03555 ENOG4108NRW Phospholipase, patatin family GPY59_RS03560 ENOG41081FY multiple antibiotic resistance (MarC)-related GPY59_RS03570 ENOG4105DAY polysaccharide export protein GPY59_RS03580 ENOG4105D75 Capsular exopolysaccharide family GPY59_RS03590 ENOG4105N0V mono-oxygenase ydhR GPY59_RS03595 ENOG4105F04 LysR family Transcriptional regulator GPY59_RS03605 ENOG4105CK2 sodium dicarboxylate symporter GPY59_RS03625 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) GPY59_RS03630 ENOG4108P2H Inner membrane protein YjiG GPY59_RS03635 ENOG41074DU domain protein GPY59_RS03650 ENOG4107T9C Alpha amylase catalytic region GPY59_RS03655 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase GPY59_RS03660 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) GPY59_RS03665 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) GPY59_RS03670 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) GPY59_RS03675 ENOG41061ZR Transcriptional regulator GPY59_RS03700 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) GPY59_RS03705 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) GPY59_RS03710 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) GPY59_RS03730 ENOG4108K8S endonuclease I GPY59_RS03750 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) GPY59_RS03760 ENOG4105EJQ L-serine dehydratase GPY59_RS03770 ENOG4105D2S major facilitator superfamily GPY59_RS03795 ENOG4105CHR reductase GPY59_RS03800 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) GPY59_RS03805 ENOG4105CNV Aldolase GPY59_RS03810 ENOG4105ETE Transcriptional regulator (LacI family GPY59_RS03815 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit GPY59_RS03825 ENOG4105CG6 trap dicarboxylate transporter dctm subunit GPY59_RS03840 ENOG4107RJ1 sodium solute GPY59_RS03845 ENOG4105ETE Transcriptional regulator (LacI family GPY59_RS03855 ENOG4105E5M Multidrug resistance protein D GPY59_RS03870 ENOG4105DR5 peptidase GPY59_RS03880 ENOG4107RAN Peptidase, M16 GPY59_RS03885 ENOG4105C8Q Methyl-accepting chemotaxis GPY59_RS03890 ENOG4105E0A ABC, transporter GPY59_RS03895 ENOG4108U1V ABC transporter, permease GPY59_RS03900 ENOG4105DQ5 transport system permease protein GPY59_RS03905 ENOG4108HUF Transporter GPY59_RS03910 ENOG4105GAV receptor GPY59_RS03915 ENOG4105E0K tonB-dependent siderophore receptor GPY59_RS03925 ENOG4105DUU IucA IucC family protein GPY59_RS03935 ENOG4105DBM Siderophore biosynthesis protein GPY59_RS03940 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) GPY59_RS03945 ENOG4108JP0 extracellular solute-binding protein family 1 GPY59_RS03950 ENOG4105DHQ Histidine kinase GPY59_RS03955 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GPY59_RS03965 ENOG4105CI1 PTS System GPY59_RS03985 ENOG4105C19 ABC transporter GPY59_RS04035 ENOG4108ZHJ Organic hydroperoxide resistance protein GPY59_RS04040 ENOG4105K56 Transcriptional regulator GPY59_RS04045 ENOG4105D3R alkyl hydroperoxide reductase GPY59_RS04050 ENOG4108JU3 Alkyl hydroperoxide reductase GPY59_RS04075 ENOG4105ECQ AraC Family Transcriptional Regulator GPY59_RS04100 ENOG4108RPX mosc domain containing protein GPY59_RS04105 ENOG4105C1J atp-dependent rna helicase GPY59_RS04115 ENOG4105BZ1 (ABC) transporter GPY59_RS04125 ENOG4105EW9 transcriptional regulator AsnC family GPY59_RS04155 ENOG4105CK7 Sodium proline symporter GPY59_RS04165 ENOG4105C26 Dehydrogenase GPY59_RS04180 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) GPY59_RS04185 ENOG4105CQZ Histidine kinase GPY59_RS04190 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GPY59_RS04195 ENOG4107QZV Type I secretion membrane fusion protein GPY59_RS04210 ENOG4108JJA ABC, transporter GPY59_RS04230 ENOG4108J59 Extracellular solute-binding protein, family 5 GPY59_RS04240 ENOG4108PSC Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity) GPY59_RS04250 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate GPY59_RS04255 ENOG4105C5Y PTS System GPY59_RS04260 ENOG4105FCK Membrane GPY59_RS04265 ENOG4105EC3 peptidase S51, dipeptidase E GPY59_RS04285 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) GPY59_RS04310 ENOG4108JQ7 (ABC) transporter GPY59_RS04335 ENOG4105BZU Histidine kinase GPY59_RS04345 ENOG4105CDY transcriptional regulatory protein GPY59_RS04350 ENOG4105CNI cell division protein FtsW GPY59_RS04360 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GPY59_RS04380 ENOG4108HRK Histidine kinase GPY59_RS04385 ENOG4108VAC response regulator GPY59_RS04395 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) GPY59_RS04400 ENOG4105C8Q Methyl-accepting chemotaxis GPY59_RS04415 ENOG4105D6U Sodium Glutamate Symporter GPY59_RS04425 ENOG4105CZV ABC transporter GPY59_RS04430 ENOG4107U9B transcriptional regulator GPY59_RS04435 ENOG4105D6U Sodium Glutamate Symporter GPY59_RS04445 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) GPY59_RS04465 ENOG4105C2I pirin domain protein GPY59_RS04470 ENOG4108VGI doxx family GPY59_RS04480 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GPY59_RS04485 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GPY59_RS04505 ENOG4105DN9 Na H antiporter GPY59_RS04520 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) GPY59_RS04535 ENOG4105NBK UPF0345 protein GPY59_RS04545 ENOG4108K0B C-di-gmp phosphodiesterase GPY59_RS04550 ENOG4105UQX Mate efflux family protein GPY59_RS04555 ENOG4105D3G Pseudouridine synthase GPY59_RS04570 ENOG4105EJC lysr family transcriptional regulator GPY59_RS04575 ENOG4108HCJ Hydrolase GPY59_RS04585 ENOG4108KHX Diguanylate cyclase GPY59_RS04595 ENOG4105C4W S-formylglutathione hydrolase GPY59_RS04605 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase GPY59_RS04610 ENOG4105CC0 LysR family Transcriptional regulator GPY59_RS04615 ENOG4105Q26 Siderophore-interacting protein GPY59_RS04625 ENOG4105EW9 transcriptional regulator AsnC family GPY59_RS04630 ENOG4108M1A Chitin-binding protein GPY59_RS04645 ENOG4107W31 Pentapeptide repeat protein GPY59_RS04650 ENOG4105EIF outer membrane protein W GPY59_RS04660 ENOG4105C0R drug resistance transporter emrb qaca subfamily GPY59_RS04675 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase GPY59_RS04710 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR GPY59_RS04715 ENOG4105C6Z Gluconate GPY59_RS04720 ENOG4105BZW Glycerate kinase GPY59_RS04725 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GPY59_RS04760 ENOG4105CYX Short-chain dehydrogenase reductase Sdr GPY59_RS04765 ENOG41068WN GPY59_RS04770 ENOG4105CUW cytochrome C-TYPE protein GPY59_RS04785 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) GPY59_RS04790 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase GPY59_RS04795 ENOG4105ETU transcriptional activator (TenA GPY59_RS04800 ENOG4107Z6I Thiamine biosynthesis protein GPY59_RS04805 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component GPY59_RS04810 ENOG4108YI8 ABC transporter GPY59_RS04815 ENOG4105DWF phosphomethylpyrimidine kinase GPY59_RS04830 ENOG4108TEM pseudouridine methyltransferase GPY59_RS04885 ENOG4108YYI Protein of unknown function (DUF2810) GPY59_RS04890 ENOG4105C5I Dehydrogenase GPY59_RS04900 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase GPY59_RS04905 ENOG4105E3W Two component transcriptional regulator (Winged helix family GPY59_RS04910 ENOG410804D Sensor Signal Transduction Histidine Kinase GPY59_RS04935 ENOG4109015 Biopolymer transport protein exbD tolR GPY59_RS04980 ENOG4105DSE periplasmic solute binding protein GPY59_RS04985 ENOG4105DIK (ABC) transporter GPY59_RS04990 ENOG4105CC5 ABC transporter GPY59_RS05005 ENOG4105CUG Oligopeptidase b GPY59_RS05010 ENOG4105E5M Multidrug resistance protein D GPY59_RS05015 ENOG4105CYW agmatinase GPY59_RS05020 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) GPY59_RS05030 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) GPY59_RS05035 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) GPY59_RS05055 ENOG4105DUM transcriptional regulator, lysR family GPY59_RS05075 ENOG4105CQZ Histidine kinase GPY59_RS05080 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GPY59_RS05085 ENOG4105BZU Histidine kinase GPY59_RS05090 ENOG4105CWM branched-chain amino acid transport system II carrier protein GPY59_RS05110 ENOG4105D5U fad dependent oxidoreductase GPY59_RS05120 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii GPY59_RS05125 ENOG4105C4M (Ubiquinol oxidase) subunit I GPY59_RS05130 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) GPY59_RS05135 ENOG4105C0F tryptophanase EC 4.1.99.1 GPY59_RS05150 ENOG4105D9N nucleoside GPY59_RS05165 ENOG4105BZU Histidine kinase GPY59_RS05180 ENOG4106TD9 Diguanylate cyclase GPY59_RS05185 ENOG4105CVP deoxyribo-dipyrimidine photolyase GPY59_RS05190 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein GPY59_RS05205 ENOG4105E0X reductase GPY59_RS05210 ENOG4108UKZ OsmC family GPY59_RS05215 ENOG4108UW5 maltose o-acetyltransferase GPY59_RS05245 ENOG4105JQN Transcriptional regulator GPY59_RS05250 ENOG4105PAD Hydrolase GPY59_RS05265 ENOG4108UUE Transcriptional regulator GPY59_RS05270 ENOG4108UHE carbonic anhydrase GPY59_RS05275 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation GPY59_RS05280 ENOG4105DJY efflux transporter, rnd family, mfp subunit GPY59_RS05285 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GPY59_RS05300 ENOG4105MKU Transcriptional regulator GPY59_RS05305 ENOG4105KUU lipolytic protein G-D-S-L family GPY59_RS05310 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin GPY59_RS05335 ENOG4105ETE Transcriptional regulator (LacI family GPY59_RS05340 ENOG4108KAZ Involved in phosphonate degradation (By similarity) GPY59_RS05345 ENOG4108JPW Aminotransferase GPY59_RS05350 ENOG4107STF Involved in phosphonate degradation (By similarity) GPY59_RS05365 ENOG4107RCV ABC transporter, permease GPY59_RS05385 ENOG4108MJ5 VirK protein GPY59_RS05410 ENOG4105CJP fad dependent oxidoreductase GPY59_RS05420 ENOG4105UYK outer membrane protein a GPY59_RS05425 ENOG4105ETT transcriptional Regulator, LysR family GPY59_RS05440 ENOG4105EJQ L-serine dehydratase GPY59_RS05460 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) GPY59_RS05465 ENOG4105E4C Lytic transglycosylase catalytic GPY59_RS05485 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) GPY59_RS05490 ENOG4108ZC9 flagellar basal-body rod protein flgc GPY59_RS05495 ENOG4105W00 Flagellar hook capping protein GPY59_RS05500 ENOG4105BZE flagellar hook protein, FlgE GPY59_RS05505 ENOG4108KPB Flagellar basal-body rod protein FlgF GPY59_RS05510 ENOG4105CGA flagellar basal-body rod protein FlgG GPY59_RS05515 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) GPY59_RS05520 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) GPY59_RS05525 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj GPY59_RS05530 ENOG4105E1Q flagellar hook-associated protein GPY59_RS05535 ENOG4105DTJ flagellar hook-associated protein GPY59_RS05555 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) GPY59_RS05570 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) GPY59_RS05580 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) GPY59_RS05585 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) GPY59_RS05595 ENOG4105N14 lysine exporter protein LysE YggA GPY59_RS05615 ENOG4107Z3H Transcriptional regulator, TetR family GPY59_RS05620 ENOG4108K3Z AraC family transcriptional regulator GPY59_RS05625 ENOG4105CPD ethanolamine ammonia-lyase GPY59_RS05630 ENOG4107FQ9 ethanolamine ammonia-lyase GPY59_RS05635 ENOG4105CUB amino acid GPY59_RS05640 ENOG4105EA8 2-Nitropropane dioxygenase GPY59_RS05645 ENOG4108F19 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) GPY59_RS05650 ENOG4105N2W Transcriptional regulator GPY59_RS05665 ENOG4108RWI nicotinamidase GPY59_RS05675 ENOG4107RH7 Nicotinate phosphoribosyltransferase GPY59_RS05700 ENOG4105ETT transcriptional Regulator, LysR family GPY59_RS05715 ENOG4105RW8 MltA-interacting MipA family protein GPY59_RS05720 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion GPY59_RS05725 ENOG4108IJ7 Glycine betaine GPY59_RS05730 ENOG4107U14 binding-protein-dependent transport systems inner membrane Component GPY59_RS05735 ENOG4105VYW UPF0251 protein GPY59_RS05760 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) GPY59_RS05770 ENOG4107S8C mandelate racemase muconate lactonizing GPY59_RS05780 ENOG4105RQF LysR family Transcriptional regulator GPY59_RS05795 ENOG4108Z4X TRANSCRIPTIONal GPY59_RS05820 ENOG4107RZC phospholipase d GPY59_RS05865 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GPY59_RS05915 ENOG4107RUE extracellular solute-binding protein family 1 GPY59_RS05920 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) GPY59_RS05925 ENOG4105WH1 Two component transcriptional regulator luxr family GPY59_RS05940 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) GPY59_RS05945 ENOG4105HDK L-asparaginase GPY59_RS05950 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis GPY59_RS05970 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme GPY59_RS05975 ENOG4105C8Y Acetylornithine aminotransferase GPY59_RS05980 ENOG4105C26 Dehydrogenase GPY59_RS05985 ENOG4108RYR transcriptional regulator AsnC family GPY59_RS05990 ENOG4105E5N succinylglutamate desuccinylase aspartoacylase GPY59_RS05995 ENOG4105ENR peptidase, M24 GPY59_RS06000 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GPY59_RS06010 ENOG4105CHR reductase GPY59_RS06020 ENOG4105CPQ Dehydrogenase GPY59_RS06025 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GPY59_RS06040 ENOG4107RSM transcriptional regulator GPY59_RS06050 ENOG4105C1J atp-dependent rna helicase GPY59_RS06080 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GPY59_RS06085 ENOG410874W AraC family transcriptional regulator GPY59_RS06090 ENOG4105HEI LysR family (Transcriptional regulator GPY59_RS06095 ENOG4105E1F short-chain dehydrogenase reductase GPY59_RS06110 ENOG4108P3C GPY59_RS06125 ENOG4105CHR reductase GPY59_RS06130 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin GPY59_RS06140 ENOG41064T2 transcriptional regulator, lysR family GPY59_RS06145 ENOG4105D05 Receptor GPY59_RS06165 ENOG4105C5Y PTS System GPY59_RS06170 ENOG4105D7K pfkb domain protein GPY59_RS06175 ENOG4108HKT sucrose-6-phosphate hydrolase GPY59_RS06185 ENOG4105CYM Glutathione S-transferase GPY59_RS06190 ENOG4105DZ1 carboxypeptidase GPY59_RS06200 ENOG4105EHV domain protein GPY59_RS06205 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) GPY59_RS06220 ENOG4105VEQ Cold shock protein GPY59_RS06225 ENOG4105EUB pirin domain protein GPY59_RS06230 ENOG4108NRW Phospholipase, patatin family GPY59_RS06245 ENOG4105EP9 oxidoreductase GPY59_RS06250 ENOG4105DIJ Phosphoethanolamine transferase GPY59_RS06255 ENOG41080IJ Diacylglycerol kinase GPY59_RS06265 ENOG4105E0F Histidine kinase GPY59_RS06270 ENOG4107EXC regulatoR GPY59_RS06285 ENOG4108Z33 Thiol disulfide Interchange Protein GPY59_RS06305 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) GPY59_RS06315 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) GPY59_RS06330 ENOG4105EST Metal Dependent Phosphohydrolase GPY59_RS06335 ENOG4105DZC cytosine deaminase GPY59_RS06340 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin GPY59_RS06345 ENOG4105CJW magnesium transporter GPY59_RS06350 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) GPY59_RS06355 ENOG4105EFX secretion protein, HlyD family GPY59_RS06380 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GPY59_RS06385 ENOG4105E0F Histidine kinase GPY59_RS06400 ENOG4105DVH amino acid GPY59_RS06415 ENOG4105DUM transcriptional regulator, lysR family GPY59_RS06440 ENOG4105BZU Histidine kinase GPY59_RS06450 ENOG41090HJ UPF0265 protein GPY59_RS06460 ENOG4108YXG UPF0502 protein GPY59_RS06465 ENOG41082IR Excinuclease ABC C subunit domain protein GPY59_RS06470 ENOG4108QGH periplasmic GPY59_RS06475 ENOG4105BZU Histidine kinase GPY59_RS06485 ENOG4105J12 Multidrug resistance protein mdtN GPY59_RS06505 ENOG4105EW9 transcriptional regulator AsnC family GPY59_RS06530 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GPY59_RS06535 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GPY59_RS06555 ENOG4105CHU acetyl-coa acetyltransferase GPY59_RS06565 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class GPY59_RS06585 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) GPY59_RS06600 ENOG4105BZU Histidine kinase GPY59_RS06605 ENOG4105WH1 Two component transcriptional regulator luxr family GPY59_RS06620 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) GPY59_RS06625 ENOG4107YWA deoxycytidylate deaminase GPY59_RS06640 ENOG4108N3W hemolysin secretion protein GPY59_RS06645 ENOG4108YZN class I peptide chain release factor GPY59_RS06650 ENOG4107VXZ Hydrolase GPY59_RS06655 ENOG4105UYK outer membrane protein a GPY59_RS06660 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) GPY59_RS06665 ENOG4105DXI Major Facilitator superfamily GPY59_RS06670 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor GPY59_RS06675 ENOG4105CV1 Transketolase (EC 2.2.1.1) GPY59_RS06680 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) GPY59_RS06695 ENOG4105KHC sulfurtransferase GPY59_RS06710 ENOG4105D06 uba thif-type nad fad binding protein GPY59_RS06715 ENOG4105CVM Molybdenum cofactor synthesis domain protein GPY59_RS06720 ENOG4105EUJ GTP cyclohydrolase i GPY59_RS06730 ENOG4105CMQ Chloride channel GPY59_RS06745 ENOG4107RGM aldo keto reductase GPY59_RS06750 ENOG4108UNF response regulator GPY59_RS06760 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) GPY59_RS06765 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) GPY59_RS06770 ENOG4107QHE Choloylglycine hydrolase GPY59_RS06815 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GPY59_RS06830 ENOG4105DR5 peptidase GPY59_RS06855 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GPY59_RS06860 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GPY59_RS06865 ENOG4108WC9 type VI secretion system effector, hcp1 family GPY59_RS06870 ENOG4105CS6 Rhs element vgr protein GPY59_RS06895 ENOG4105D9P serine threonine protein kinase GPY59_RS06930 ENOG4105EW9 transcriptional regulator AsnC family GPY59_RS07055 ENOG4105C2C drug resistance transporter, Bcr CflA GPY59_RS07065 ENOG4105HEI LysR family (Transcriptional regulator GPY59_RS07070 ENOG4105EMU Dehydrogenase GPY59_RS07075 ENOG4105Q9Y Universal stress protein GPY59_RS07085 ENOG4105D65 subunit l GPY59_RS07090 ENOG4105MKQ Monovalent cation H antiporter subunit C GPY59_RS07095 ENOG4108JPZ Monovalent cation H antiporter subunit D GPY59_RS07100 ENOG4105SC1 monovalent cation H antiporter subunit E GPY59_RS07105 ENOG41080TA Multiple resistance and ph regulation protein f GPY59_RS07110 ENOG4105KJM monovalent cation h antiporter subunit g GPY59_RS07115 ENOG4105FDP GntR family transcriptional regulator GPY59_RS07120 ENOG4105F8D glycoside hydrolase family 4 GPY59_RS07125 ENOG4105CI1 PTS System GPY59_RS07130 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GPY59_RS07135 ENOG4105C10 Electron transfer flavoprotein GPY59_RS07140 ENOG4105BZJ Electron transfer flavoprotein GPY59_RS07145 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase GPY59_RS07155 ENOG4105C0Z ABC transporter GPY59_RS07160 ENOG4108IQE Amp-dependent synthetase and ligase GPY59_RS07180 ENOG4108IV0 ABC, transporter GPY59_RS07185 ENOG4105DZS Phenylacetate-CoA ligase GPY59_RS07190 ENOG4105FQ6 thiopurine methyltransferase GPY59_RS07200 ENOG4105C7K acetolactate synthase GPY59_RS07205 ENOG4107FQX Alpha-acetolactate decarboxylase GPY59_RS07215 ENOG4108S58 Phenazine biosynthesis protein PhzF GPY59_RS07225 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii GPY59_RS07230 ENOG4105C4M (Ubiquinol oxidase) subunit I GPY59_RS07235 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GPY59_RS07240 ENOG4108UW5 maltose o-acetyltransferase GPY59_RS07250 ENOG4105EGS Mechanosensitive ion channel GPY59_RS07260 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase GPY59_RS07270 ENOG4108IPT Naphthoate synthase GPY59_RS07275 ENOG4107QX3 carboxylase GPY59_RS07280 ENOG4105C1G acyl-Coa dehydrogenase GPY59_RS07290 ENOG4105CHU acetyl-coa acetyltransferase GPY59_RS07295 ENOG4105C26 Dehydrogenase GPY59_RS07300 ENOG4105C1G acyl-Coa dehydrogenase GPY59_RS07305 ENOG4105E39 Enoyl-CoA hydratase GPY59_RS07315 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase GPY59_RS07325 ENOG4105BZU Histidine kinase GPY59_RS07330 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) GPY59_RS07335 ENOG4105C26 Dehydrogenase GPY59_RS07340 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) GPY59_RS07350 ENOG4108HQS Glycine betaine GPY59_RS07355 ENOG4108IJ7 Glycine betaine GPY59_RS07360 ENOG4108RCM Nitroreductase GPY59_RS07370 ENOG4107QX8 SPFH domain, Band 7 family protein GPY59_RS07380 ENOG4105CA0 peroxidase GPY59_RS07385 ENOG4105BZU Histidine kinase GPY59_RS07395 ENOG4105D82 Glutamate dehydrogenase GPY59_RS07455 ENOG4108K0B C-di-gmp phosphodiesterase GPY59_RS07460 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) GPY59_RS07465 ENOG4105C2J ABC transporter GPY59_RS07470 ENOG4105CNN ABC, transporter GPY59_RS07475 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator GPY59_RS07480 ENOG4108RVA ribokinase GPY59_RS07485 ENOG4105ETE Transcriptional regulator (LacI family GPY59_RS07495 ENOG4106Z1T Nicotinamide Mononucleotide Transporter GPY59_RS07500 ENOG4108I5U Uridine phosphorylase GPY59_RS07515 ENOG4105DHS permease protein GPY59_RS07520 ENOG4105CM4 permease protein GPY59_RS07525 ENOG4108IPW abc transporter atp-binding protein GPY59_RS07530 ENOG4108Z6Z Transcriptional regulator GPY59_RS07535 ENOG4108W3Q Transcriptional regulator GPY59_RS07570 ENOG4105EM2 membrane GPY59_RS07575 ENOG41088T4 Helicase IV GPY59_RS07580 ENOG4108Z5K methylglyoxal synthase GPY59_RS07585 ENOG4108SV3 Tmao reductase system periplasmic protein tort GPY59_RS07590 ENOG4105BZU Histidine kinase GPY59_RS07605 ENOG4105E3W Two component transcriptional regulator (Winged helix family GPY59_RS07610 ENOG4105ENH Sulfatase GPY59_RS07620 ENOG41061MV Arylsulfatase GPY59_RS07625 ENOG4105C4X radical SAM domain protein GPY59_RS07630 ENOG4105C7R Atpase associated with various cellular activities aaa_3 GPY59_RS07660 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) GPY59_RS07665 ENOG41064T2 transcriptional regulator, lysR family GPY59_RS07670 ENOG4107TE5 Lipid kinase GPY59_RS07675 ENOG4108YDI single-species biofilm formation on inanimate substrate GPY59_RS07685 ENOG4105F2V VRR-NUC domain-containing protein GPY59_RS07700 ENOG4105CEE C4-dicarboxylate transporter GPY59_RS07720 ENOG4108MGY Histidine kinase GPY59_RS07725 ENOG4107KBT 8-Amino-7-oxononanoate synthase GPY59_RS07730 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) GPY59_RS07735 ENOG4105BZU Histidine kinase GPY59_RS07740 ENOG4105BZU Histidine kinase GPY59_RS07745 ENOG4105WH1 Two component transcriptional regulator luxr family GPY59_RS07750 ENOG4105BZU Histidine kinase GPY59_RS07760 ENOG4108WQH regulatoR GPY59_RS07770 ENOG4107R88 Chemotaxis protein (CheV) GPY59_RS07775 ENOG4108VAU general secretion pathway protein G GPY59_RS07785 ENOG4105FR1 rard protein GPY59_RS07810 ENOG4108I0N Transporter, RarD family, DMT superfamily protein GPY59_RS07825 ENOG4107RGH Aldehyde dehydrogenase GPY59_RS07835 ENOG4105CBC glutamate synthase GPY59_RS07840 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) GPY59_RS07865 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GPY59_RS07870 ENOG4108UYE Lactoylglutathione lyase GPY59_RS07890 ENOG4105CJW magnesium transporter GPY59_RS07920 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GPY59_RS07935 ENOG4105HDD phospholipase GPY59_RS07960 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) GPY59_RS08015 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) GPY59_RS08020 ENOG4108UZ3 Transporter GPY59_RS08025 ENOG4105EJC lysr family transcriptional regulator GPY59_RS08030 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) GPY59_RS08040 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase GPY59_RS08045 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor GPY59_RS08050 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) GPY59_RS08055 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) GPY59_RS08065 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) GPY59_RS08095 ENOG4105DM4 PTS System GPY59_RS08100 ENOG4105DE4 1-phosphofructokinase GPY59_RS08105 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein GPY59_RS08110 ENOG4107B7Y DNA-binding transcriptional regulator FruR GPY59_RS08125 ENOG4108NJZ Sensory box GGDEF EAL domain protein GPY59_RS08130 ENOG4105DRP amino acid AbC transporter GPY59_RS08135 ENOG4106TNF Periplasmic binding protein GPY59_RS08140 ENOG4105E5Q amino acid AbC transporter GPY59_RS08145 ENOG4105CDA abc transporter atp-binding protein GPY59_RS08155 ENOG4108I6A alcohol dehydrogenase GPY59_RS08160 ENOG4105CF7 AraC family transcriptional regulator GPY59_RS08175 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) GPY59_RS08180 ENOG4105CKU formyltetrahydrofolate synthetase GPY59_RS08190 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) GPY59_RS08200 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) GPY59_RS08205 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) GPY59_RS08220 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) GPY59_RS08225 ENOG4107R73 Mate efflux family protein GPY59_RS08235 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) GPY59_RS08240 ENOG4105E55 glycerol-3-phosphate acyltransferase GPY59_RS08245 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) GPY59_RS08250 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) GPY59_RS08255 ENOG4105X6C Flagellar basal body-associated protein FliL GPY59_RS08260 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) GPY59_RS08265 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) GPY59_RS08270 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GPY59_RS08275 ENOG4105CRP Part of the ABC transporter FtsEX involved in GPY59_RS08280 ENOG4105CAK Cell division ATP-binding protein ftsE GPY59_RS08285 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) GPY59_RS08290 ENOG4106H78 methyltransferase GPY59_RS08300 ENOG41076UM multiple antibiotic resistance (MarC)-related protein GPY59_RS08340 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase GPY59_RS08345 ENOG41082YX Transcriptional regulator, arsr family GPY59_RS08350 ENOG4105D58 Diguanylate phosphodiesterase GPY59_RS08355 ENOG410829K Lysine exporter protein (Lyse ygga) GPY59_RS08360 ENOG4108EUD Lysophospholipase GPY59_RS08365 ENOG4105DQF Hydrolase GPY59_RS08380 ENOG4106IUH DTW domain containing protein GPY59_RS08385 ENOG4105BZU Histidine kinase GPY59_RS08390 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant GPY59_RS08395 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GPY59_RS08405 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) GPY59_RS08410 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) GPY59_RS08420 ENOG4105XQ6 frataxin-like protein GPY59_RS08425 ENOG4107T0K Adenylate cyclase GPY59_RS08430 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) GPY59_RS08435 ENOG41076E6 Uroporphyrinogen-III Synthase GPY59_RS08440 ENOG4105ECF c-methyltransferase GPY59_RS08445 ENOG410601J HemY protein GPY59_RS08485 ENOG4107QK7 reductase GPY59_RS08490 ENOG4108ZIT Ferredoxin, 2FE-2S GPY59_RS08495 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) GPY59_RS08505 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) GPY59_RS08510 ENOG4105K63 Thioredoxin GPY59_RS08515 ENOG4105C1J atp-dependent rna helicase GPY59_RS08520 ENOG4105C9X ppx gppa phosphatase GPY59_RS08530 ENOG4105EX9 Membrane GPY59_RS08540 ENOG4105C9U ATP-dependent DNA helicase RecQ GPY59_RS08545 ENOG4105FR1 rard protein GPY59_RS08560 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) GPY59_RS08570 ENOG4105C4R Atp-dependent dna helicase GPY59_RS08580 ENOG4105E18 UPF0276 protein GPY59_RS08610 ENOG4105DC7 peptidase M24 GPY59_RS08610 ENOG4105DC7 peptidase M24 GPY59_RS08615 ENOG4105D41 biosynthesis protein thiH GPY59_RS08620 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) GPY59_RS08625 ENOG4105WHD thiamine biosynthesis protein ThiS GPY59_RS08630 ENOG4105D06 uba thif-type nad fad binding protein GPY59_RS08640 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) GPY59_RS08645 ENOG4105WMR Protein CrcB homolog GPY59_RS08650 ENOG4105E3B Multicopper oxidase GPY59_RS08695 ENOG4108Z0R Transferase GPY59_RS08700 ENOG4105SG3 Protein of unknown function (DUF1488) GPY59_RS08705 ENOG4105E2X shikimate dehydrogenase GPY59_RS08710 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) GPY59_RS08715 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GPY59_RS08720 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) GPY59_RS08725 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit GPY59_RS08730 ENOG4108WI1 Dna topoisomerase GPY59_RS08735 ENOG4108RPN Protein smg homolog GPY59_RS08740 ENOG4105C79 DNA protecting protein DprA GPY59_RS08755 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) GPY59_RS08760 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B GPY59_RS08765 ENOG4105C1A potassium transporter peripheral membrane GPY59_RS08770 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) GPY59_RS08780 ENOG4108UT2 hemolysin iii GPY59_RS08785 ENOG4108N23 SpoOM-related protein GPY59_RS08795 ENOG4105PC1 Conserved Protein GPY59_RS08805 ENOG4105E27 serine threonine protein kinase GPY59_RS08810 ENOG4108Z33 Thiol disulfide Interchange Protein GPY59_RS08815 ENOG4106HNH Acyl-transferase GPY59_RS08825 ENOG4105C0P Mg chelatase subunit ChlI GPY59_RS08835 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit GPY59_RS08840 ENOG4105CM2 brancheD-chain amino acid aminotransferase GPY59_RS08845 ENOG4105C01 Dihydroxy-acid dehydratase GPY59_RS08850 ENOG4105C7B Threonine dehydratase GPY59_RS08855 ENOG4105F52 Transcriptional regulator GPY59_RS08860 ENOG4105CZQ inner membrane transport protein YdhC GPY59_RS08865 ENOG4105F87 Dehydratase GPY59_RS08870 ENOG4105EAD ABC transporter GPY59_RS08875 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) GPY59_RS08880 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) GPY59_RS08885 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) GPY59_RS08890 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) GPY59_RS08895 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) GPY59_RS08900 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) GPY59_RS08910 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) GPY59_RS08915 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) GPY59_RS08920 ENOG410684E atp synthase GPY59_RS08925 ENOG4105FA0 parb-like partition protein GPY59_RS08930 ENOG4107QJE Chromosome Partitioning Protein GPY59_RS08935 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) GPY59_RS08940 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) GPY59_RS08945 ENOG4105QTB Flavodoxin GPY59_RS08950 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) GPY59_RS08955 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins GPY59_RS08960 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) GPY59_RS08965 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) GPY59_RS08975 ENOG4105CDA abc transporter atp-binding protein GPY59_RS08980 ENOG4105E5Q amino acid AbC transporter GPY59_RS08985 ENOG4105EAB amino acid AbC transporter GPY59_RS08995 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) GPY59_RS09000 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) GPY59_RS09005 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) GPY59_RS09010 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GPY59_RS09025 ENOG4108ZNX Heat shock protein GPY59_RS09030 ENOG4105JKW Valine--pyruvate aminotransferase GPY59_RS09035 ENOG4107T9C Alpha amylase catalytic region GPY59_RS09040 ENOG4105C38 Glycyl-tRNA synthetase beta subunit GPY59_RS09045 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit GPY59_RS09060 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) GPY59_RS09075 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family GPY59_RS09080 ENOG4105CHU acetyl-coa acetyltransferase GPY59_RS09085 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GPY59_RS09090 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein GPY59_RS09095 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) GPY59_RS09100 ENOG4108RR8 protoporphyrinogen oxidase GPY59_RS09135 ENOG4105EMY transcriptional regulator GPY59_RS09140 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase GPY59_RS09145 ENOG4105W0Z cytoplasmic protein GPY59_RS09150 ENOG4105BZS acriflavin resistance protein GPY59_RS09155 ENOG410624X efflux transporter, rnd family, mfp subunit GPY59_RS09160 ENOG41067SE Tetr family transcriptional regulator GPY59_RS09165 ENOG4105C4R Atp-dependent dna helicase GPY59_RS09170 ENOG4105MPD Cytochrome GPY59_RS09210 ENOG4108JQ6 ABC transporter GPY59_RS09215 ENOG4107QSI ABC, transporter GPY59_RS09220 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GPY59_RS09225 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GPY59_RS09240 ENOG4105DIQ Transcriptional regulator GPY59_RS09245 ENOG41064T2 transcriptional regulator, lysR family GPY59_RS09250 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) GPY59_RS09255 ENOG4108ZBZ Catalyzes the excretion of spermidine (By similarity) GPY59_RS09260 ENOG4105C01 Dihydroxy-acid dehydratase GPY59_RS09265 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family GPY59_RS09270 ENOG4105C6Z Gluconate GPY59_RS09275 ENOG4108UHU Aldolase GPY59_RS09280 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) GPY59_RS09285 ENOG4107RSM transcriptional regulator GPY59_RS09290 ENOG4105DC8 reductase GPY59_RS09295 ENOG4105D6S protein involved in catabolism of external DNA GPY59_RS09300 ENOG4105DGW oligopeptidase A GPY59_RS09305 ENOG4108VVK transcriptional Regulator, AsnC GPY59_RS09310 ENOG4105BZU Histidine kinase GPY59_RS09315 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) GPY59_RS09325 ENOG4105EMK carboxylate amino acid amine transporter GPY59_RS09330 ENOG4108M6U Universal stress protein A GPY59_RS09335 ENOG41090A1 ferritin GPY59_RS09340 ENOG4108V6B universal stress protein B GPY59_RS09345 ENOG4105CBX hi0933 family GPY59_RS09350 ENOG4108JUA Transcriptional regulator GPY59_RS09375 ENOG4107TE5 Lipid kinase GPY59_RS09405 ENOG4105DSF transport protein GPY59_RS09410 ENOG4105BZU Histidine kinase GPY59_RS09420 ENOG4105CGY Dna recombination protein GPY59_RS09425 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GPY59_RS09430 ENOG4105JC1 sterol-binding domain protein GPY59_RS09435 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) GPY59_RS09440 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) GPY59_RS09445 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) GPY59_RS09450 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) GPY59_RS09460 ENOG4105F8V Hydrolase, tatD family GPY59_RS09470 ENOG4105D52 delta-aminolevulinic acid dehydratase GPY59_RS09475 ENOG4105KD7 acetyltransferase GPY59_RS09485 ENOG4105C2M dna polymerase I GPY59_RS09490 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) GPY59_RS09495 ENOG4106RE7 Cytochrome GPY59_RS09510 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) GPY59_RS09515 ENOG4105XCT Protein of unknown function (DUF2489) GPY59_RS09520 ENOG4105D4P Coproporphyrinogen iii oxidase GPY59_RS09525 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) GPY59_RS09530 ENOG4105BZU Histidine kinase GPY59_RS09535 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GPY59_RS09540 ENOG4105CUX Signal transduction histidine kinase GPY59_RS09550 ENOG4105C5F glutamine synthetase GPY59_RS09560 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) GPY59_RS09570 ENOG4107S2Z UPF0761 membrane protein GPY59_RS09575 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) GPY59_RS09580 ENOG4105SUU thioesterase domain GPY59_RS09590 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase GPY59_RS09595 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) GPY59_RS09600 ENOG4105VEJ Heat shock protein GPY59_RS09605 ENOG4108XKW General secretion pathway protein C GPY59_RS09615 ENOG4107QHF type ii secretion system protein e GPY59_RS09620 ENOG4105D7Q type ii secretion system GPY59_RS09625 ENOG4108VAU general secretion pathway protein G GPY59_RS09630 ENOG4105VWV general secretion pathway protein h GPY59_RS09635 ENOG4105X5Z General secretion pathway protein I GPY59_RS09640 ENOG4108WWZ General secretion pathway protein J GPY59_RS09645 ENOG4108RTD type II secretion system protein K GPY59_RS09650 ENOG4108BY5 Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity) GPY59_RS09655 ENOG4105U1E general secretion pathway protein M GPY59_RS09660 ENOG4105PIC general secretion pathway protein N GPY59_RS09670 ENOG4107RK2 ADP-ribose diphosphatase NudE GPY59_RS09675 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) GPY59_RS09680 ENOG4105MJ2 Competence protein GPY59_RS09685 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) GPY59_RS09695 ENOG4105BZM domain protein GPY59_RS09705 ENOG4108RRZ Transcription elongation factor GreB GPY59_RS09715 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GPY59_RS09720 ENOG4105E0F Histidine kinase GPY59_RS09725 ENOG4105C2W permease GPY59_RS09730 ENOG4105CB5 ATP-dependent DNA helicase recG GPY59_RS09735 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase GPY59_RS09740 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) GPY59_RS09745 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) GPY59_RS09750 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) GPY59_RS09765 ENOG4109015 Biopolymer transport protein exbD tolR GPY59_RS09795 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component GPY59_RS09800 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component GPY59_RS09805 ENOG4107QRA Extracellular solute-binding protein, family 5 GPY59_RS09815 ENOG4108JQ7 (ABC) transporter GPY59_RS09825 ENOG4105DSJ YicC domain protein GPY59_RS09830 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) GPY59_RS09835 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) GPY59_RS09840 ENOG4105D1S lipid A biosynthesis GPY59_RS09845 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) GPY59_RS09850 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase GPY59_RS09855 ENOG4105C8Q Methyl-accepting chemotaxis GPY59_RS09860 ENOG4105W5Q DNA repair protein (RadC GPY59_RS09865 ENOG4105KDC 50s ribosomal protein l28 GPY59_RS09880 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) GPY59_RS09885 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) GPY59_RS09890 ENOG4108JMC lipopolysaccharide core biosynthesis protein GPY59_RS09900 ENOG4106WTF Glycosyl transferase, family 2 GPY59_RS09905 ENOG4105DKP glycosyl transferase, family 9 GPY59_RS09910 ENOG41080IJ Diacylglycerol kinase GPY59_RS09915 ENOG4108W7E Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity) GPY59_RS09920 ENOG4105C1B dTDP-glucose 4-6-dehydratase GPY59_RS09945 ENOG4108P1X synthase GPY59_RS09955 ENOG4105CHR reductase GPY59_RS09960 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) GPY59_RS09985 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase GPY59_RS09990 ENOG4105XA0 heptosyltransferase ii GPY59_RS09995 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase GPY59_RS10000 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) GPY59_RS10005 ENOG4105E3R (LipO)protein GPY59_RS10015 ENOG4108Y9B (LipO)protein GPY59_RS10045 ENOG4105C1B dTDP-glucose 4-6-dehydratase GPY59_RS10050 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) GPY59_RS10060 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase GPY59_RS10080 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) GPY59_RS10110 ENOG4105ESV Glycosyl transferase, family 4 GPY59_RS10120 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase GPY59_RS10125 ENOG4105CP7 Triose-phosphate isomerase GPY59_RS10155 ENOG4105CBT Fructose-1,6-bisphosphatase GPY59_RS10160 ENOG41065UX Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) GPY59_RS10165 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) GPY59_RS10170 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase GPY59_RS10175 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) GPY59_RS10180 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) GPY59_RS10190 ENOG4105ETE Transcriptional regulator (LacI family GPY59_RS10195 ENOG4105C25 Primosomal protein n' GPY59_RS10205 ENOG4105VFB Binds the 23S rRNA (By similarity) GPY59_RS10210 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) GPY59_RS10215 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) GPY59_RS10220 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) GPY59_RS10225 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) GPY59_RS10230 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity GPY59_RS10235 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) GPY59_RS10240 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) GPY59_RS10245 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) GPY59_RS10250 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) GPY59_RS10255 ENOG41083MP 50s ribosomal protein l29 GPY59_RS10260 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal GPY59_RS10265 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) GPY59_RS10270 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) GPY59_RS10275 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits GPY59_RS10280 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) GPY59_RS10285 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) GPY59_RS10290 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) GPY59_RS10300 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) GPY59_RS10305 ENOG4105VPB 50S ribosomal protein L30 GPY59_RS10310 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) GPY59_RS10315 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) GPY59_RS10325 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits GPY59_RS10330 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) GPY59_RS10335 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) GPY59_RS10340 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GPY59_RS10345 ENOG4108ZT0 50S ribosomal protein l17 GPY59_RS10355 ENOG4108V1T peptidylprolyl cis-trans isomerase GPY59_RS10365 ENOG4107YB6 acetyltransferase, (GNAT) family GPY59_RS10370 ENOG4105C1J atp-dependent rna helicase GPY59_RS10380 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic GPY59_RS10385 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GPY59_RS10390 ENOG4105C11 sulfate adenylyltransferase), subunit 2 GPY59_RS10395 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) GPY59_RS10405 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) GPY59_RS10425 ENOG4108I0Y (ABC) transporter GPY59_RS10440 ENOG4108UUE Transcriptional regulator GPY59_RS10445 ENOG41061GZ Protein of unknown function (DUF1107) GPY59_RS10450 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) GPY59_RS10455 ENOG4105CFU surface antigen GPY59_RS10460 ENOG4105MA0 exported protein GPY59_RS10465 ENOG41066HZ AIG2-like family GPY59_RS10475 ENOG4105F0N pyrophosphate phospho-hydrolase GPY59_RS10480 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 GPY59_RS10490 ENOG4105DFU Cell wall formation (By similarity) GPY59_RS10495 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase GPY59_RS10500 ENOG4105DP9 ABC transporter GPY59_RS10505 ENOG4106SMU thiamine transporter membrane protein GPY59_RS10510 ENOG4107T0D ABC, transporter GPY59_RS10515 ENOG4105CC0 LysR family Transcriptional regulator GPY59_RS10520 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GPY59_RS10545 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) GPY59_RS10550 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) GPY59_RS10560 ENOG4105EAH synthase GPY59_RS10565 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) GPY59_RS10570 ENOG4105K46 50S ribosomal protein l27 GPY59_RS10575 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control GPY59_RS10580 ENOG4105DWK Membrane GPY59_RS10585 ENOG4107XM3 UPF0442 protein GPY59_RS10590 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) GPY59_RS10595 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) GPY59_RS10600 ENOG4105NWN ApaG protein GPY59_RS10605 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) GPY59_RS10610 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) GPY59_RS10615 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) GPY59_RS10620 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) GPY59_RS10625 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) GPY59_RS10635 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GPY59_RS10640 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GPY59_RS10645 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) GPY59_RS10650 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) GPY59_RS10675 ENOG41064T2 transcriptional regulator, lysR family GPY59_RS10680 ENOG4108IQE Amp-dependent synthetase and ligase GPY59_RS10685 ENOG4105C7K acetolactate synthase GPY59_RS10690 ENOG4108ZP8 Acetolactate synthase small subunit GPY59_RS10695 ENOG4105BZU Histidine kinase GPY59_RS10705 ENOG4105CA9 Pyruvate kinase GPY59_RS10710 ENOG410804X Transcriptional regulator GPY59_RS10715 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) GPY59_RS10725 ENOG4105CMT Dihydroxyacetone kinase GPY59_RS10730 ENOG4108UTZ Dihydroxyacetone kinase GPY59_RS10745 ENOG4105E61 Mannitol repressor protein GPY59_RS10750 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase GPY59_RS10755 ENOG4105CTS PTS system mannitol-specific GPY59_RS10775 ENOG4105D01 (LipO)protein GPY59_RS10780 ENOG4105DFP Integrase GPY59_RS10790 ENOG4105EKQ RNA-directed DNA polymerase GPY59_RS10805 ENOG4108JJA ABC, transporter GPY59_RS10960 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GPY59_RS10965 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) GPY59_RS10970 ENOG4105KTH gatB Yqey GPY59_RS10975 ENOG4105VCC 30S ribosomal protein S21 GPY59_RS10980 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GPY59_RS10985 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) GPY59_RS10990 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) GPY59_RS10995 ENOG4107ZVW dihydroneopterin aldolase GPY59_RS11000 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase GPY59_RS11005 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) GPY59_RS11010 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate GPY59_RS11025 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) GPY59_RS11030 ENOG4106MWK domain protein GPY59_RS11035 ENOG4105CJ3 phosphate transporter GPY59_RS11040 ENOG4107IX6 phosphate transport regulator GPY59_RS11045 ENOG4105I7R Adenylate cyclase GPY59_RS11055 ENOG4105C8Q Methyl-accepting chemotaxis GPY59_RS11060 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) GPY59_RS11065 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) GPY59_RS11070 ENOG4105DFG type I secretion outer membrane protein GPY59_RS11075 ENOG41087AY ADP-Ribose pyrophosphatase GPY59_RS11080 ENOG4108SX3 cytoplasmic protein GPY59_RS11085 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) GPY59_RS11090 ENOG4105IPS esterase GPY59_RS11095 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GPY59_RS11100 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GPY59_RS11105 ENOG4105C0H protease GPY59_RS11110 ENOG4105C0H protease GPY59_RS11115 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III GPY59_RS11125 ENOG4105D6Z AFG1 family ATPase GPY59_RS11135 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) GPY59_RS11140 ENOG4108UJD 30S ribosomal protein S9 GPY59_RS11145 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) GPY59_RS11150 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) GPY59_RS11155 ENOG4105EIX cytochrome c1 GPY59_RS11160 ENOG4107MKT Stringent starvation protein a GPY59_RS11165 ENOG4105KB2 stringent starvation protein b GPY59_RS11170 ENOG4105W4M Transport-associated protein GPY59_RS11175 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) GPY59_RS11180 ENOG41082RQ UPF0102 protein GPY59_RS11190 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) GPY59_RS11205 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) GPY59_RS11210 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) GPY59_RS11215 ENOG4105CJN penicillin-binding protein GPY59_RS11220 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) GPY59_RS11225 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) GPY59_RS11230 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) GPY59_RS11235 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) GPY59_RS11245 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) GPY59_RS11250 ENOG4105DFU Cell wall formation (By similarity) GPY59_RS11255 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) GPY59_RS11260 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) GPY59_RS11265 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) GPY59_RS11270 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) GPY59_RS11280 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving GPY59_RS11285 ENOG4105M6F mutator MutT protein GPY59_RS11290 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) GPY59_RS11295 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain GPY59_RS11300 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain GPY59_RS11315 ENOG4105EJ9 Membrane GPY59_RS11320 ENOG4105VP0 transcriptional regulator, lysR family GPY59_RS11325 ENOG4105EN6 Membrane GPY59_RS11330 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) GPY59_RS11335 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) GPY59_RS11340 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) GPY59_RS11350 ENOG4105BZ8 glutamate synthase GPY59_RS11355 ENOG4105CBC glutamate synthase GPY59_RS11370 ENOG4105N5T Radical SAM Protein GPY59_RS11380 ENOG4105BZU Histidine kinase GPY59_RS11390 ENOG41065U4 response regulator GPY59_RS11405 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) GPY59_RS11425 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) GPY59_RS11430 ENOG4105D98 threonine synthase GPY59_RS11440 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) GPY59_RS11445 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) GPY59_RS11455 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) GPY59_RS11470 ENOG4105BZG amino acid carrier protein GPY59_RS11475 ENOG4105D1Q UPF0246 protein GPY59_RS11480 ENOG4105C1J atp-dependent rna helicase GPY59_RS11485 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) GPY59_RS11490 ENOG4105CWM branched-chain amino acid transport system II carrier protein GPY59_RS11495 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) GPY59_RS11500 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GPY59_RS11505 ENOG4105T95 Thiol disulfide interChange protein GPY59_RS11510 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) GPY59_RS11520 ENOG4105CRK lysyL-tRNA synthetase GPY59_RS11525 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GPY59_RS11535 ENOG4105CPC Aldo Keto reductase GPY59_RS11545 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) GPY59_RS11555 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) GPY59_RS11560 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase GPY59_RS11565 ENOG4105HF0 Membrane GPY59_RS11570 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) GPY59_RS11575 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) GPY59_RS11590 ENOG41063Z6 transcriptional regulator, lysR family GPY59_RS11595 ENOG41080HT Transcriptional regulator, arsr family GPY59_RS11600 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) GPY59_RS11605 ENOG4105CJR Integral membrane protein (MviN GPY59_RS11610 ENOG4105DTN riboflavin biosynthesis protein ribF GPY59_RS11615 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) GPY59_RS11620 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) GPY59_RS11625 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase GPY59_RS11630 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) GPY59_RS11640 ENOG4108NEV two component transcriptional regulator, LytTR family GPY59_RS11645 ENOG4108HRK Histidine kinase GPY59_RS11665 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate GPY59_RS11670 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) GPY59_RS11675 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) GPY59_RS11680 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) GPY59_RS11685 ENOG4105EHE chorismate mutase- prephenate dehydrogenase GPY59_RS11690 ENOG4105DR5 peptidase GPY59_RS11700 ENOG4105C5H ABC transporter GPY59_RS11705 ENOG4107SC1 transglycosylase GPY59_RS11710 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) GPY59_RS11715 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) GPY59_RS11725 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA GPY59_RS11735 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane GPY59_RS11740 ENOG4105C34 Pseudouridine synthase GPY59_RS11745 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase GPY59_RS11750 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GPY59_RS11810 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding GPY59_RS11815 ENOG4105CFP Peptidase U32 GPY59_RS11820 ENOG4105DH7 May be involved in recombination (By similarity) GPY59_RS11825 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GPY59_RS11830 ENOG4105BZU Histidine kinase GPY59_RS11840 ENOG4105C9X ppx gppa phosphatase GPY59_RS11845 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) GPY59_RS11850 ENOG4105C8U phosphate abc transporter GPY59_RS11855 ENOG4105E2Z phosphate ABC transporter (Permease GPY59_RS11860 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) GPY59_RS11870 ENOG4105CSR polyphosphate kinase 2 GPY59_RS11875 ENOG4106N3A copper homeostasis protein cutc GPY59_RS11880 ENOG4105D3R alkyl hydroperoxide reductase GPY59_RS11885 ENOG4105C5Q Transcriptional regulator GPY59_RS11895 ENOG4107QP3 malate synthase g GPY59_RS11900 ENOG4108I9X Isocitrate lyase GPY59_RS11905 ENOG4105W87 Cbs domain GPY59_RS11915 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) GPY59_RS11920 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) GPY59_RS11925 ENOG4105VIE preprotein translocase, subunit YajC GPY59_RS11930 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GPY59_RS11935 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GPY59_RS11950 ENOG4105ECY inositol monophosphatase GPY59_RS11955 ENOG4105CVS RNA methyltransferase TrmH family, group 1 GPY59_RS11960 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family GPY59_RS11965 ENOG4105C3J Cysteine desulfurase GPY59_RS11970 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins GPY59_RS11975 ENOG4108Z4V iron-sulfur cluster assembly GPY59_RS11980 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) GPY59_RS11985 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB GPY59_RS11990 ENOG4108ZIT Ferredoxin, 2FE-2S GPY59_RS11995 ENOG4105WVQ Fe-S assembly protein IscX GPY59_RS12000 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) GPY59_RS12005 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) GPY59_RS12010 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs GPY59_RS12020 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) GPY59_RS12025 ENOG4105CUT histidyl-tRNA synthetase GPY59_RS12030 ENOG4105N21 Membrane GPY59_RS12035 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) GPY59_RS12040 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) GPY59_RS12055 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) GPY59_RS12060 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) GPY59_RS12065 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) GPY59_RS12070 ENOG4107S6Z Na H antiporter GPY59_RS12080 ENOG4106HK8 GPR1 FUN34 yaaH family protein GPY59_RS12085 ENOG4105BZG amino acid carrier protein GPY59_RS12100 ENOG4108IQK o-acetylhomoserine GPY59_RS12105 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GPY59_RS12125 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase GPY59_RS12130 ENOG4105ETT transcriptional Regulator, LysR family GPY59_RS12180 ENOG4108YGG dna repair protein GPY59_RS12200 ENOG4105DZR Type I site-specific deoxyribonuclease GPY59_RS12220 ENOG4105DFP Integrase GPY59_RS12230 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) GPY59_RS12235 ENOG4108Z1B Cyclase dehydrase GPY59_RS12240 ENOG4105VDB UPF0125 protein GPY59_RS12245 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) GPY59_RS12255 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) GPY59_RS12265 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) GPY59_RS12270 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ GPY59_RS12275 ENOG4105CK2 sodium dicarboxylate symporter GPY59_RS12280 ENOG4105CFG Acts as a chaperone (By similarity) GPY59_RS12285 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) GPY59_RS12320 ENOG4105CFC Transporter GPY59_RS12325 ENOG4108Z6B deaminase GPY59_RS12335 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) GPY59_RS12340 ENOG4108ETH Formylglycinamide ribotide synthetase GPY59_RS12370 ENOG4105CIN aminoacyl-histidine dipeptidase GPY59_RS12375 ENOG4105C7N Xanthine uracil vitamin C permease GPY59_RS12380 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) GPY59_RS12385 ENOG4108DJV Fermentation respiration switch protein GPY59_RS12390 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) GPY59_RS12395 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) GPY59_RS12400 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) GPY59_RS12405 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) GPY59_RS12410 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) GPY59_RS12425 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) GPY59_RS12430 ENOG4107YIM Involved in the transcription termination process (By similarity) GPY59_RS12435 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) GPY59_RS12440 ENOG4108ZAI phosphatidylglycerophosphatase a GPY59_RS12445 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) GPY59_RS12450 ENOG4105CTB Polyprenyl synthetase GPY59_RS12455 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) GPY59_RS12460 ENOG4105E14 MotA TolQ exbB proton channel GPY59_RS12465 ENOG4106VK6 Flagellar motor protein GPY59_RS12470 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) GPY59_RS12475 ENOG4105ETT transcriptional Regulator, LysR family GPY59_RS12485 ENOG4105M08 Membrane GPY59_RS12490 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) GPY59_RS12495 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease GPY59_RS12500 ENOG4105EWT decarboxylase family GPY59_RS12505 ENOG4105BZU Histidine kinase GPY59_RS12515 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) GPY59_RS12520 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) GPY59_RS12525 ENOG4105EXF Zn-ribbon-containing, possibly nucleic-acid-binding protein GPY59_RS12530 ENOG4105D01 (LipO)protein GPY59_RS12535 ENOG4108UMI ABC transporter, permease GPY59_RS12540 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) GPY59_RS12545 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase GPY59_RS12550 ENOG4105D4X repressor GPY59_RS12555 ENOG4105C5Y PTS System GPY59_RS12560 ENOG4105CG3 alpha amylase, catalytic region GPY59_RS12575 ENOG4108JYZ YitT family GPY59_RS12580 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) GPY59_RS12585 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) GPY59_RS12590 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) GPY59_RS12595 ENOG4108Z43 UPF0250 protein GPY59_RS12600 ENOG4105DZ1 carboxypeptidase GPY59_RS12605 ENOG4105K6T rare lipoprotein A GPY59_RS12610 ENOG4105CNI cell division protein FtsW GPY59_RS12615 ENOG4105CJN penicillin-binding protein GPY59_RS12620 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) GPY59_RS12625 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) GPY59_RS12630 ENOG4105DJF DNA polymerase III, delta' subunit GPY59_RS12635 ENOG4108U2H Rare lipoprotein B GPY59_RS12640 ENOG4105C8T Leucyl-tRNA synthetase GPY59_RS12645 ENOG4107PAI alpha helical protein GPY59_RS12650 ENOG4108RS6 transposase GPY59_RS12655 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) GPY59_RS12660 ENOG4108JU5 Magnesium and cobalt efflux protein GPY59_RS12665 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) GPY59_RS12670 ENOG4105C9A Phoh family GPY59_RS12675 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) GPY59_RS12685 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family GPY59_RS12795 ENOG4105C3G gtp-binding protein GPY59_RS12800 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) GPY59_RS12805 ENOG4105C5T Phosphoribosyl pyrophosphate synthase GPY59_RS12810 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) GPY59_RS12815 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) GPY59_RS12820 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) GPY59_RS12825 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) GPY59_RS12830 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) GPY59_RS12835 ENOG4108YY7 Invasion gene expression up-regulator SirB GPY59_RS12840 ENOG41063JG Transcriptional regulator GPY59_RS12845 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase GPY59_RS12850 ENOG4105CGH 5'-nucleotidase GPY59_RS12855 ENOG4108Z66 YbaK ebsC protein GPY59_RS12860 ENOG4105FE9 pseudouridine synthase GPY59_RS12865 ENOG4108DG9 Smr protein MutS2 GPY59_RS12890 ENOG4105E2D ec 3.2.1.52 GPY59_RS12905 ENOG4105C59 p-type ATPase GPY59_RS12915 ENOG41081QG Porin Gram-negative type GPY59_RS12925 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) GPY59_RS12930 ENOG4105UYK outer membrane protein a GPY59_RS12975 ENOG4107R88 Chemotaxis protein (CheV) GPY59_RS12980 ENOG4105BZU Histidine kinase GPY59_RS12985 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) GPY59_RS12990 ENOG4108ZC9 flagellar basal-body rod protein flgc GPY59_RS12995 ENOG4105W00 Flagellar hook capping protein GPY59_RS13000 ENOG4105BZE flagellar hook protein, FlgE GPY59_RS13005 ENOG4108KPB Flagellar basal-body rod protein FlgF GPY59_RS13010 ENOG4105CGA flagellar basal-body rod protein FlgG GPY59_RS13015 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) GPY59_RS13020 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) GPY59_RS13025 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj GPY59_RS13035 ENOG4105DTJ flagellar hook-associated protein GPY59_RS13040 ENOG4105I03 Flagellin GPY59_RS13050 ENOG4105I03 Flagellin GPY59_RS13065 ENOG4105C5Y PTS System GPY59_RS13070 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) GPY59_RS13075 ENOG4105KZ7 phosphocarrier protein hpr GPY59_RS13085 ENOG4105C6T cysteine synthase GPY59_RS13090 ENOG4105EXN Sulfate transport protein CysZ GPY59_RS13095 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) GPY59_RS13100 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) GPY59_RS13115 ENOG4107QX8 SPFH domain, Band 7 family protein GPY59_RS13120 ENOG4107QR8 Thioredoxin GPY59_RS13130 ENOG4105E1F short-chain dehydrogenase reductase GPY59_RS13135 ENOG4105ECP epimerase GPY59_RS13165 ENOG4108RE9 Phosphodiesterase GPY59_RS13185 ENOG4108DQ1 activator toxR GPY59_RS13190 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) GPY59_RS13195 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) GPY59_RS13200 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) GPY59_RS13205 ENOG4105DUX Transporter GPY59_RS13210 ENOG4105MDZ Transcriptional activator rfaH GPY59_RS13215 ENOG4105CAQ asparagine synthetase GPY59_RS13220 ENOG4105CKD glutathione-regulated potassium-efflux system protein GPY59_RS13225 ENOG4105E2R ROK family GPY59_RS13230 ENOG4105CE4 GlcNAc 6-P deacetylase GPY59_RS13240 ENOG4105CI1 PTS System GPY59_RS13245 ENOG4105CX6 glutaminyL-tRNA synthetase GPY59_RS13250 ENOG41090R7 Ferric uptake GPY59_RS13260 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) GPY59_RS13270 ENOG4105EV9 Alpha Beta Hydrolase GPY59_RS13275 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) GPY59_RS13280 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 GPY59_RS13290 ENOG4107QNR UPF0135 protein GPY59_RS13295 ENOG4105BZN citrate synthase GPY59_RS13300 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit GPY59_RS13305 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein GPY59_RS13310 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) GPY59_RS13315 ENOG4105E33 succinate dehydrogenase GPY59_RS13320 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 GPY59_RS13325 ENOG4105C7S Dehydrogenase GPY59_RS13330 ENOG4105CMV Succinyl-CoA synthetase subunit beta GPY59_RS13335 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha GPY59_RS13340 ENOG4105FAV ABC, transporter GPY59_RS13345 ENOG4105FDK ABC transporter GPY59_RS13350 ENOG4105NXV High-affinity zinc uptake system protein GPY59_RS13355 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) GPY59_RS13360 ENOG4105XFK Ferrous iron transport protein A GPY59_RS13385 ENOG4105C75 arginyL-tRNA synthetase GPY59_RS13395 ENOG4106ZCM YecM protein GPY59_RS13400 ENOG4105CIY formyltetrahydrofolate deformylase GPY59_RS13405 ENOG4105DVT helicase GPY59_RS13410 ENOG41072GX Peptidase M22 Glycoprotease GPY59_RS13420 ENOG4105R8X Outer membrane lipoprotein Slp GPY59_RS13425 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) GPY59_RS13430 ENOG4105CEY Amp-dependent synthetase and ligase GPY59_RS13435 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) GPY59_RS13440 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) GPY59_RS13445 ENOG4107QMS site-determining protein GPY59_RS13450 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) GPY59_RS13455 ENOG4105VNG YcgL domain-containing protein GPY59_RS13460 ENOG4105CVE Lytic murein transglycosylase GPY59_RS13470 ENOG4105D9N nucleoside GPY59_RS13475 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) GPY59_RS13485 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GPY59_RS13495 ENOG4105C2D reductase GPY59_RS13500 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) GPY59_RS13505 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GPY59_RS13530 ENOG4105C84 Histidine ammonia-lyase GPY59_RS13535 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) GPY59_RS13540 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) GPY59_RS13560 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) GPY59_RS13595 ENOG4105C1J atp-dependent rna helicase GPY59_RS13600 ENOG4107ZYR domain protein GPY59_RS13620 ENOG4105CNG UPF0061 protein GPY59_RS13625 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit GPY59_RS13630 ENOG410835K Tripartite ATP-Independent Periplasmic transporter DctQ GPY59_RS13635 ENOG4105CG6 trap dicarboxylate transporter dctm subunit GPY59_RS13640 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GPY59_RS13645 ENOG4105CQZ Histidine kinase GPY59_RS13650 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation GPY59_RS13655 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GPY59_RS13660 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) GPY59_RS13665 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) GPY59_RS13670 ENOG4105K70 DNA-binding protein GPY59_RS13675 ENOG4105EIN peptidylprolyl cis-trans isomerase GPY59_RS13680 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein GPY59_RS13695 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein GPY59_RS13700 ENOG4105DK2 UPF0207 protein GPY59_RS13705 ENOG4105CHM Aminotransferase GPY59_RS13710 ENOG4105E4F Isochorismate synthase GPY59_RS13715 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) GPY59_RS13725 ENOG4108IPT Naphthoate synthase GPY59_RS13730 ENOG4105DNI Converts SHCHC to OSB (By similarity) GPY59_RS13735 ENOG4105CEY Amp-dependent synthetase and ligase GPY59_RS13745 ENOG4105HMI Membrane GPY59_RS13750 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) GPY59_RS13795 ENOG4105EP1 Efflux transporter rnd family, mfp subunit GPY59_RS13800 ENOG4105BZS acriflavin resistance protein GPY59_RS13815 ENOG4105C6T cysteine synthase GPY59_RS13820 ENOG4108XM1 transcriptional regulator AsnC family GPY59_RS13830 ENOG4105C29 acyl-CoA thioesterase GPY59_RS13835 ENOG4108MNP Glycoprotein polysaccharide metabolism GPY59_RS13850 ENOG4105BZU Histidine kinase GPY59_RS13865 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) GPY59_RS13875 ENOG4107SXA Phosphorylase GPY59_RS13885 ENOG4108NVR Methyl-accepting chemotaxis GPY59_RS13890 ENOG4105K59 histidine triad (HIT) protein GPY59_RS13915 ENOG4105D0Y UPF0227 protein GPY59_RS13920 ENOG4105CEP NADH dehydrogenase GPY59_RS13935 ENOG4108JA2 transcriptioN-repair coupling factor GPY59_RS13945 ENOG4105D60 lipoprotein releasing system transmembrane protein GPY59_RS13950 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) GPY59_RS13955 ENOG4105D60 lipoprotein releasing system transmembrane protein GPY59_RS13965 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 GPY59_RS13970 ENOG4105BZ1 (ABC) transporter GPY59_RS13975 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) GPY59_RS13980 ENOG4105W49 UPF0434 protein GPY59_RS13985 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) GPY59_RS13990 ENOG4105ED1 spovr family GPY59_RS13995 ENOG4106AKX UPF0229 protein GPY59_RS14000 ENOG4105CYN Serine protein kinase GPY59_RS14005 ENOG4105XWI UPF0304 protein GPY59_RS14015 ENOG4105F1A Pyruvate formate-lyase GPY59_RS14025 ENOG4105C6N Formate acetyltransferase GPY59_RS14045 ENOG4108JEH abc transporter atp-binding protein GPY59_RS14050 ENOG4105E89 ABC transporter GPY59_RS14055 ENOG4105DSP amino acid AbC transporter GPY59_RS14070 ENOG4105CGK Exodeoxyribonuclease III GPY59_RS14075 ENOG4106428 Protein of unknown function (DUF2496) GPY59_RS14080 ENOG4108URS primosomal replication protein n'' GPY59_RS14085 ENOG4105EJ9 Membrane GPY59_RS14090 ENOG4105DVT helicase GPY59_RS14095 ENOG4105SDR Outer membrane protein OmpT GPY59_RS14105 ENOG4108R99 pseudouridine synthase GPY59_RS14115 ENOG4105VEQ Cold shock protein GPY59_RS14120 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) GPY59_RS14125 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GPY59_RS14130 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) GPY59_RS14135 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate GPY59_RS14140 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) GPY59_RS14150 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase GPY59_RS14155 ENOG4105RKX Protein of unknown function (DUF2498) GPY59_RS14160 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) GPY59_RS14165 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) GPY59_RS14170 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) GPY59_RS14190 ENOG4105HP8 regulator of competence-specific genes GPY59_RS14195 ENOG4105ETE Transcriptional regulator (LacI family GPY59_RS14200 ENOG4109039 Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) GPY59_RS14205 ENOG4106WF9 DNA-binding transcriptional regulator TorR GPY59_RS14210 ENOG4107S90 membrAne GPY59_RS14215 ENOG4106371 Methyltransferase GPY59_RS14220 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) GPY59_RS14225 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) GPY59_RS14230 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) GPY59_RS14250 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) GPY59_RS14260 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) GPY59_RS14265 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) GPY59_RS14270 ENOG41081XQ Conserved Protein GPY59_RS14275 ENOG4105C9M aspartyl-trna synthetase GPY59_RS14280 ENOG4105CDY transcriptional regulatory protein GPY59_RS14285 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) GPY59_RS14290 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) GPY59_RS14295 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) GPY59_RS14300 ENOG4105C4M (Ubiquinol oxidase) subunit I GPY59_RS14305 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii GPY59_RS14320 ENOG4107YD3 Thioesterase GPY59_RS14325 ENOG4105E02 MotA TolQ exbB proton channel GPY59_RS14330 ENOG4105M8F Biopolymer transport protein exbD tolR GPY59_RS14340 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) GPY59_RS14345 ENOG4105KCK Peptidoglycan-associated lipoprotein GPY59_RS14350 ENOG4105UFD tol-pal system protein YbgF GPY59_RS14355 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) GPY59_RS14365 ENOG4105Z6B inner membrane protein yjfl GPY59_RS14375 ENOG4106032 Glutathionylspermidine synthase GPY59_RS14385 ENOG4105BZU Histidine kinase GPY59_RS14390 ENOG4108RNS Exports L-alanine (By similarity) GPY59_RS14415 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GPY59_RS14435 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii GPY59_RS14440 ENOG4105C4M (Ubiquinol oxidase) subunit I GPY59_RS14455 ENOG4105C8Q Methyl-accepting chemotaxis GPY59_RS14460 ENOG4105C1P efflux transporter, rnd family, mfp subunit GPY59_RS14465 ENOG4105BZS acriflavin resistance protein GPY59_RS14500 ENOG4108NVR Methyl-accepting chemotaxis GPY59_RS14505 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase GPY59_RS14515 ENOG4107R11 Transcriptional regulator GPY59_RS14525 ENOG4105DCF alanine dehydrogenase GPY59_RS14530 ENOG4105EW9 transcriptional regulator AsnC family GPY59_RS14535 ENOG4105CNU cell division protein FtsK GPY59_RS14540 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) GPY59_RS14545 ENOG4105D1H recombination factor protein RarA GPY59_RS14550 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) GPY59_RS14565 ENOG4105KSC Transcriptional regulator, TraR DksA family GPY59_RS14575 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) GPY59_RS14580 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) GPY59_RS14590 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) GPY59_RS14600 ENOG4105D0M Protease HtpX homolog GPY59_RS14610 ENOG4107FW0 short-chain dehydrogenase reductase GPY59_RS14625 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase GPY59_RS14635 ENOG4105RHG GPY59_RS14645 ENOG4107QTF adenylosuccinate lyase GPY59_RS14650 ENOG41075W9 High frequency lysogenization protein HflD homolog GPY59_RS14655 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) GPY59_RS14665 ENOG4107RE1 Inosine-guanosine kinase GPY59_RS14670 ENOG4108YX2 DNA-binding protein GPY59_RS14675 ENOG4107S6Z Na H antiporter GPY59_RS14680 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) GPY59_RS14685 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) GPY59_RS14690 ENOG4105CIH Imidazole acetol-phosphate transaminase GPY59_RS14720 ENOG4105K5B UPF0225 protein GPY59_RS14725 ENOG4105D58 Diguanylate phosphodiesterase GPY59_RS14730 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) GPY59_RS14735 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) GPY59_RS14740 ENOG4105C8N cysteinyl-tRNA synthetase GPY59_RS14745 ENOG4107104 thymidine kinase GPY59_RS14750 ENOG4107DB1 DUF218 domain GPY59_RS14775 ENOG4105TMB Formate nitrite transporter GPY59_RS14800 ENOG4108J2R molybdopterin oxidoreductase GPY59_RS14815 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase GPY59_RS14825 ENOG4108JQ2 peptide transport system atp-binding protein GPY59_RS14830 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein GPY59_RS14835 ENOG4108EU3 peptide transport system, permease GPY59_RS14840 ENOG4108I5W peptide transport system, permease protein GPY59_RS14845 ENOG4108J59 Extracellular solute-binding protein, family 5 GPY59_RS14850 ENOG4105E51 psp operon transcriptional activator GPY59_RS14855 ENOG41087YS Phage shock protein A GPY59_RS14860 ENOG4105YYT phage shock protein B GPY59_RS14865 ENOG4105FM1 phage shock protein C GPY59_RS14885 ENOG4108R3E Dna-3-methyladenine glycosylase i GPY59_RS14895 ENOG4107IFA Lipase (EC 3.1.1.3) GPY59_RS14900 ENOG4105C28 cystathionine GPY59_RS14905 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) GPY59_RS14910 ENOG4105C8J )-transporter GPY59_RS14915 ENOG4108W1A pseudouridine synthase GPY59_RS14925 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) GPY59_RS14930 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) GPY59_RS14935 ENOG4108JUA Transcriptional regulator GPY59_RS14950 ENOG4108T9J Cdp-alcohol phosphatidyltransferase GPY59_RS14955 ENOG4108VGW abc transporter atp-binding protein GPY59_RS14960 ENOG4105CXZ ABC transporter, permease GPY59_RS14965 ENOG4105VNH ABC transporter solute-binding protein GPY59_RS14975 ENOG4105XZD Fe-S protein GPY59_RS14990 ENOG4105CGH 5'-nucleotidase GPY59_RS15000 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) GPY59_RS15005 ENOG4105EB3 Histidine kinase GPY59_RS15010 ENOG4105ETX regulatoR GPY59_RS15020 ENOG4105CFI type iii restriction protein res subunit GPY59_RS15025 ENOG4105I08 Pseudouridine synthase GPY59_RS15030 ENOG4105C2C drug resistance transporter, Bcr CflA GPY59_RS15040 ENOG4105CGD Nad-dependent epimerase dehydratase GPY59_RS15045 ENOG4107QI1 Mate efflux family protein GPY59_RS15065 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) GPY59_RS15070 ENOG41067SE Tetr family transcriptional regulator GPY59_RS15075 ENOG4107QPN acyl-Coa dehydrogenase GPY59_RS15080 ENOG4105RKW reductase (By GPY59_RS15085 ENOG4105D0C transport protein GPY59_RS15090 ENOG41090BQ Glutaredoxin GPY59_RS15100 ENOG4106KNT transcriptional regulator GPY59_RS15105 ENOG4105DY8 decarboxylase GPY59_RS15115 ENOG4105DWU Membrane GPY59_RS15145 ENOG4105BZU Histidine kinase GPY59_RS15155 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) GPY59_RS15160 ENOG4105BZC d-serine deaminase GPY59_RS15165 ENOG4108JJ8 (ABC) transporter GPY59_RS15170 ENOG4108JJ9 ABC, transporter GPY59_RS15175 ENOG4105C3M thioredoxin reductase GPY59_RS15195 ENOG4105BZU Histidine kinase GPY59_RS15200 ENOG4105C8P )-transporter GPY59_RS15205 ENOG4107GZ4 SanA protein GPY59_RS15210 ENOG4107R1I NAD-dependent malic enzyme GPY59_RS15215 ENOG4105CQ7 ATP-dependent helicase GPY59_RS15230 ENOG4105C8V SAICAR synthetase GPY59_RS15250 ENOG4105CDV Ompa motb domain protein GPY59_RS15265 ENOG4105CQB FAD linked oxidase domain protein GPY59_RS15280 ENOG4105C84 Histidine ammonia-lyase GPY59_RS15290 ENOG41088SP formiminoglutamate hydrolase GPY59_RS15295 ENOG4105CI2 imidazolone-5-propionate hydrolase GPY59_RS15300 ENOG4105CZE histidine utilization repressor GPY59_RS15315 ENOG4105C22 threonyL-tRNA synthetase GPY59_RS15320 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) GPY59_RS15325 ENOG41082NX 50s ribosomal protein l35 GPY59_RS15330 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) GPY59_RS15335 ENOG4105K8R UPF0145 protein GPY59_RS15370 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) GPY59_RS15375 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) GPY59_RS15385 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) GPY59_RS15395 ENOG4105FQ6 thiopurine methyltransferase GPY59_RS15400 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR GPY59_RS15405 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) GPY59_RS15410 ENOG41067MG lrgb family GPY59_RS15415 ENOG4105VAW lrga family GPY59_RS15420 ENOG4105CJB Exodeoxyribonuclease I GPY59_RS15425 ENOG4108ETY sodium dicarboxylate symporter GPY59_RS15430 ENOG4105K4T epimerase GPY59_RS15435 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) GPY59_RS15440 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) GPY59_RS15460 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) GPY59_RS15465 ENOG4108IU2 vtamin B12-transporter permease GPY59_RS15470 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) GPY59_RS15490 ENOG4105F04 LysR family Transcriptional regulator GPY59_RS15500 ENOG4108VKG metal-dependent hydrolase GPY59_RS15505 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) GPY59_RS15535 ENOG4105CTU Proline racemase GPY59_RS15550 ENOG4105CIF Ornithine Cyclodeaminase GPY59_RS15555 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GPY59_RS15560 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GPY59_RS15565 ENOG4105F38 ABC transporter, permease GPY59_RS15570 ENOG4105D38 putrescine abc transporter GPY59_RS15580 ENOG4107MM9 BNR Asp-box repeat-containing protein GPY59_RS15590 ENOG4108JQ7 (ABC) transporter GPY59_RS15595 ENOG4105C3U ABC transporter GPY59_RS15600 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GPY59_RS15605 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GPY59_RS15610 ENOG4107QSI ABC, transporter GPY59_RS15615 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) GPY59_RS15620 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase GPY59_RS15625 ENOG4105F1J Homogentisate 1,2-dioxygenase GPY59_RS15635 ENOG4108RXX maleylacetoacetate isomerase GPY59_RS15685 ENOG4105VTN Protein of unknown function (DUF1311) GPY59_RS15710 ENOG4105KK4 UPF0060 membrane protein GPY59_RS15725 ENOG4107S6Z Na H antiporter GPY59_RS15730 ENOG4105CFQ glutamine synthetase GPY59_RS15740 ENOG4108Z86 Glutamine amidotransferase GPY59_RS15745 ENOG4107VRI Transcriptional regulator GPY59_RS15750 ENOG4105C26 Dehydrogenase GPY59_RS15755 ENOG4105CJP fad dependent oxidoreductase GPY59_RS15765 ENOG4105DWY Agmatine deiminase GPY59_RS15770 ENOG4105C26 Dehydrogenase GPY59_RS15775 ENOG4108JPW Aminotransferase GPY59_RS15780 ENOG4105BZU Histidine kinase GPY59_RS15790 ENOG4108ZT1 Transcriptional regulator GPY59_RS15795 ENOG4105MSB protein, conserved in bacteria GPY59_RS15820 ENOG4105BZU Histidine kinase GPY59_RS15825 ENOG4105BZU Histidine kinase GPY59_RS15835 ENOG41090FY type IV pilus biogenesis stability protein PilW GPY59_RS15840 ENOG4105CVG Homoserine O-transsuccinylase GPY59_RS15855 ENOG4105D1S lipid A biosynthesis GPY59_RS15860 ENOG4105CTD carboxy-peptidase GPY59_RS15865 ENOG410829K Lysine exporter protein (Lyse ygga) GPY59_RS15875 ENOG4105BZG amino acid carrier protein GPY59_RS15900 ENOG4105E0M Sulfatase GPY59_RS15905 ENOG4105GIJ Glycine betaine GPY59_RS15910 ENOG4108HQS Glycine betaine GPY59_RS15915 ENOG4108IJ7 Glycine betaine GPY59_RS15930 ENOG4105C94 Transporter GPY59_RS15935 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase GPY59_RS15940 ENOG4108JPW Aminotransferase GPY59_RS15945 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) GPY59_RS15950 ENOG4105CZK Aspartate kinase GPY59_RS15955 ENOG4105ENH Sulfatase GPY59_RS15970 ENOG4105C4X radical SAM domain protein GPY59_RS15985 ENOG4105ENH Sulfatase GPY59_RS15990 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) GPY59_RS16000 ENOG4108JJA ABC, transporter GPY59_RS16010 ENOG4105DFG type I secretion outer membrane protein GPY59_RS16025 ENOG4105E98 transcriptional regulator DeoR family GPY59_RS16030 ENOG4105D9R oxidoreductase GPY59_RS16035 ENOG41090KN UPF0303 protein GPY59_RS16040 ENOG4105BZU Histidine kinase GPY59_RS16060 ENOG4105C8P )-transporter GPY59_RS16070 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GPY59_RS16075 ENOG4105BZU Histidine kinase GPY59_RS16080 ENOG4105CPI Metal Dependent Phosphohydrolase GPY59_RS16085 ENOG410829K Lysine exporter protein (Lyse ygga) GPY59_RS16090 ENOG4105G0K glycine radical enzyme YjjI family GPY59_RS16095 ENOG41076CZ activating enzyme GPY59_RS16105 ENOG4105EE5 Membrane protein terC GPY59_RS16115 ENOG4105DHT Metal Dependent Phosphohydrolase GPY59_RS16125 ENOG4105E0U tyrosine-specific transport protein GPY59_RS16130 ENOG4105CPI Metal Dependent Phosphohydrolase GPY59_RS16140 ENOG4105E0A ABC, transporter GPY59_RS16145 ENOG4105J76 Periplasmic binding protein GPY59_RS16150 ENOG4105S6R Iron-hydroxamate transporter permease subunit GPY59_RS16155 ENOG4105E0K tonB-dependent siderophore receptor GPY59_RS16165 ENOG4105BZ1 (ABC) transporter GPY59_RS16170 ENOG4105BZ1 (ABC) transporter GPY59_RS16175 ENOG4108VAU general secretion pathway protein G GPY59_RS16185 ENOG4105CR8 Transcriptional regulator GPY59_RS16210 ENOG4105CFG Acts as a chaperone (By similarity) GPY59_RS16215 ENOG4105CFG Acts as a chaperone (By similarity) GPY59_RS16260 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) GPY59_RS16265 ENOG4105CQ7 ATP-dependent helicase GPY59_RS16280 ENOG4105C94 Transporter GPY59_RS16295 ENOG4107R8N Glycosyl transferase, family 2 GPY59_RS16300 ENOG4105CPK Glycosyl transferase (Group 1 GPY59_RS16330 ENOG4107TYR Glycosyl Transferase GPY59_RS16340 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GPY59_RS16355 ENOG4107V1M polysaccharide export protein GPY59_RS16365 ENOG41082AN stage II sporulation protein GPY59_RS16380 ENOG4107QI1 Mate efflux family protein GPY59_RS16385 ENOG4108R6K riboflavin synthase, subunit alpha GPY59_RS16395 ENOG4105FGM Fructosamine kinase GPY59_RS16405 ENOG4105BZU Histidine kinase GPY59_RS16415 ENOG4107TT5 NLP P60 protein GPY59_RS16445 ENOG4106IUH DTW domain containing protein GPY59_RS16450 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) GPY59_RS16460 ENOG4105CVM Molybdenum cofactor synthesis domain protein GPY59_RS16465 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) GPY59_RS16470 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GPY59_RS16485 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GPY59_RS16490 ENOG4105BZU Histidine kinase GPY59_RS16500 ENOG4105C5H ABC transporter GPY59_RS16505 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) GPY59_RS16525 ENOG4109039 Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) GPY59_RS16535 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) GPY59_RS16540 ENOG4105QAX Iron-sulfur GPY59_RS16575 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) GPY59_RS16580 ENOG4107RUE extracellular solute-binding protein family 1 GPY59_RS16585 ENOG4107RUE extracellular solute-binding protein family 1 GPY59_RS16590 ENOG4105D38 putrescine abc transporter GPY59_RS16595 ENOG4105F38 ABC transporter, permease GPY59_RS16600 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GPY59_RS16620 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) GPY59_RS16625 ENOG4105Q9Y Universal stress protein GPY59_RS16630 ENOG4105DS0 Transcriptional regulator, Crp Fnr family GPY59_RS16645 ENOG4105C59 p-type ATPase GPY59_RS16655 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) GPY59_RS16670 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i GPY59_RS16790 ENOG4105VZ1 Replication Protein GPY59_RS16825 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) GPY59_RS16830 ENOG4105DAN ATP-dependent protease GPY59_RS16835 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) GPY59_RS16850 ENOG4105C5H ABC transporter GPY59_RS16860 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) GPY59_RS16865 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) GPY59_RS16870 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) GPY59_RS16875 ENOG4105C7I Dehydrogenase GPY59_RS16885 ENOG4105CD8 aminopeptidase N GPY59_RS16895 ENOG4105CN1 protease GPY59_RS16900 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) GPY59_RS16905 ENOG4108ZGC gaf domain protein GPY59_RS16910 ENOG4105BZ1 (ABC) transporter GPY59_RS16915 ENOG4105H2K paraquat-inducible protein a GPY59_RS16920 ENOG4105DY2 Paraquat-inducible protein b GPY59_RS16925 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B GPY59_RS16945 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) GPY59_RS16950 ENOG4108VPT UPF0234 protein GPY59_RS16960 ENOG4107QXX ABC transporter GPY59_RS16965 ENOG4105EZ7 amino acid ABC transporter GPY59_RS16970 ENOG4105DRP amino acid AbC transporter GPY59_RS16975 ENOG4105CDA abc transporter atp-binding protein GPY59_RS16980 ENOG4108MN8 Membrane GPY59_RS16990 ENOG4108Z0T Part of a sulfur-relay system (By similarity) GPY59_RS16995 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 GPY59_RS17000 ENOG4105C8Q Methyl-accepting chemotaxis GPY59_RS17005 ENOG4105DR4 Methyltransferase GPY59_RS17020 ENOG4105KCK Peptidoglycan-associated lipoprotein GPY59_RS17035 ENOG4105CDV Ompa motb domain protein GPY59_RS17045 ENOG4105BZU Histidine kinase GPY59_RS17050 ENOG4107HP6 Transcriptional regulator GPY59_RS17060 ENOG4105CV8 reductase GPY59_RS17065 ENOG4105HEI LysR family (Transcriptional regulator GPY59_RS17075 ENOG4105HEI LysR family (Transcriptional regulator GPY59_RS17080 ENOG4105F27 Major Facilitator GPY59_RS17095 ENOG41063TF transcriptional regulator (AraC GPY59_RS17100 ENOG4108W2Y isochorismatase GPY59_RS17115 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein GPY59_RS17120 ENOG4105C3R Methionine synthase GPY59_RS17125 ENOG4105CDA abc transporter atp-binding protein GPY59_RS17130 ENOG4105EAD ABC transporter GPY59_RS17135 ENOG4106PMH Extracellular solute-binding protein family 3 GPY59_RS17150 ENOG4105CC0 LysR family Transcriptional regulator GPY59_RS17165 ENOG4105HEI LysR family (Transcriptional regulator GPY59_RS17170 ENOG41090KR LysR family transcriptional Regulator GPY59_RS17185 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) GPY59_RS17190 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) GPY59_RS17195 ENOG410667J hydrolase GPY59_RS17205 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap GPY59_RS17215 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GPY59_RS17220 ENOG4105C7F AcnD-accessory protein PrpF GPY59_RS17225 ENOG4108I0Z Aconitate hydratase GPY59_RS17230 ENOG4105BZN citrate synthase GPY59_RS17235 ENOG4105CR4 methylisocitrate lyase GPY59_RS17270 ENOG4105EJ9 Membrane GPY59_RS17385 ENOG4105E7U AraC family transcriptional regulator GPY59_RS17455 ENOG41066XE Type III export protein GPY59_RS17485 ENOG4108KB1 transcriptional regulator, arac family GPY59_RS17505 ENOG4105C26 Dehydrogenase GPY59_RS17510 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family GPY59_RS17525 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) GPY59_RS17530 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) GPY59_RS17535 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase GPY59_RS17550 ENOG4106YYS transcriptional regulatory protein GPY59_RS17555 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism GPY59_RS17570 ENOG4107KET secretion protein, HlyD family GPY59_RS17585 ENOG4105DUM transcriptional regulator, lysR family GPY59_RS17600 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) GPY59_RS17605 ENOG4105CEB Aspartate aminotransferase GPY59_RS17610 ENOG4105D0C transport protein GPY59_RS17620 ENOG4105Y49 secretion protein, HlyD family GPY59_RS17635 ENOG4105EBR Carboxylesterase GPY59_RS17640 ENOG4107RZC phospholipase d GPY59_RS17645 ENOG4105CFU surface antigen GPY59_RS17650 ENOG41090VV Protein of unknown function (DUF2846) GPY59_RS17655 ENOG4105N14 lysine exporter protein LysE YggA GPY59_RS17665 ENOG4105KCV RNA signal recognition particle 4.5S RNA GPY59_RS17685 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) GPY59_RS17690 ENOG41068WN GPY59_RS17695 ENOG4108UW5 maltose o-acetyltransferase GPY59_RS17770 ENOG4105CYX Short-chain dehydrogenase reductase Sdr GPY59_RS17825 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA GPY59_RS17910 ENOG4108RXX maleylacetoacetate isomerase GPY59_RS17950 ENOG4105K4U addiction module toxin, RelE StbE family GPY59_RS18010 ENOG410822N TonB family GPY59_RS18415 ENOG4105HHM rdd domain containing protein GPY59_RS18755 ENOG4105D9U N-acetyltransferase GPY59_RS18765 ENOG4106K28 UPF0283 membrane protein GPY59_RS18770 ENOG4105CM6 amino acid regulated cytosolic protein GPY59_RS18790 ENOG4105CRQ synthase (Component I) GPY59_RS18805 ENOG4105P8F nudix hydrolase GPY59_RS18810 ENOG4105C44 Serine transporter GPY59_RS18815 ENOG4105EJQ L-serine dehydratase GPY59_RS18820 ENOG4105BZU Histidine kinase GPY59_RS18830 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase GPY59_RS18835 ENOG4105C8Q Methyl-accepting chemotaxis GPY59_RS18840 ENOG4105C5S asparaginyl-tRNA synthetase GPY59_RS18850 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GPY59_RS18865 ENOG4105CGF Aromatic amino acid aminotransferase GPY59_RS18885 ENOG4105C8Q Methyl-accepting chemotaxis GPY59_RS18890 ENOG4105C94 Transporter GPY59_RS18910 ENOG4105CG6 trap dicarboxylate transporter dctm subunit GPY59_RS18920 ENOG4105CH5 extracellular solute-binding protein, family 7 GPY59_RS18935 ENOG4105C5X domain protein GPY59_RS18940 ENOG4105EAQ (twin-arginine translocation) pathway signal GPY59_RS18945 ENOG4105DIT ErfK YbiS YcfS YnhG family protein GPY59_RS18970 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) GPY59_RS18980 ENOG4108DMF Cytochrome C biogenesis protein GPY59_RS18985 ENOG4107QX9 Thiol disulfide interChange protein GPY59_RS18990 ENOG4105DA4 cytochrome c-type biogenesis protein GPY59_RS18995 ENOG4105DVI reductase, NrfD GPY59_RS19000 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein GPY59_RS19010 ENOG4105EAU Plays a role in nitrite reduction (By similarity) GPY59_RS19025 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GPY59_RS19030 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) GPY59_RS19035 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GPY59_RS19040 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GPY59_RS19065 ENOG4105D3D Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine (By similarity) GPY59_RS19105 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) GPY59_RS19110 ENOG4105WH1 Two component transcriptional regulator luxr family GPY59_RS19115 ENOG4105CQ2 DNA polymerase GPY59_RS19130 ENOG4108W5H UPF0263 protein GPY59_RS19135 ENOG4105FE9 pseudouridine synthase GPY59_RS19145 ENOG4107RTD sua5 ycio yrdc ywlc family protein GPY59_RS19150 ENOG4105DB7 PHP domain protein GPY59_RS19160 ENOG4105CRQ synthase (Component I) GPY59_RS19165 ENOG4105DDQ anthranilate synthase GPY59_RS19170 ENOG4108I0Q anthranilate phosphoribosyltransferase GPY59_RS19175 ENOG4105DK0 Indole-3-glycerol phosphate synthase GPY59_RS19180 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) GPY59_RS19185 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) GPY59_RS19190 ENOG4105DS0 Transcriptional regulator, Crp Fnr family GPY59_RS19195 ENOG4105CEY Amp-dependent synthetase and ligase GPY59_RS19200 ENOG4105CK2 sodium dicarboxylate symporter GPY59_RS19210 ENOG4105BZU Histidine kinase GPY59_RS19220 ENOG4107835 probably involved in intracellular septation (By similarity) GPY59_RS19225 ENOG4105NAU thioesterase Superfamily protein GPY59_RS19230 ENOG4105K9H YciI-like protein GPY59_RS19240 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) GPY59_RS19245 ENOG4105DZ2 Transcriptional regulator GPY59_RS19265 ENOG4105CCT upf0313 protein GPY59_RS19310 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) GPY59_RS19320 ENOG4105ETX regulatoR GPY59_RS19325 ENOG41062D9 Histidine kinase GPY59_RS19345 ENOG4105JQN Transcriptional regulator GPY59_RS19350 ENOG4105J12 Multidrug resistance protein mdtN GPY59_RS19360 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) GPY59_RS19420 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GPY59_RS19425 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GPY59_RS19430 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GPY59_RS19440 ENOG4105DJY efflux transporter, rnd family, mfp subunit GPY59_RS19460 ENOG4105N6Y Thioredoxin GPY59_RS19465 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) GPY59_RS19475 ENOG4108ZXC Two component transcriptional regulator, luxr family GPY59_RS19480 ENOG4106AFQ Histidine kinase GPY59_RS19485 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein GPY59_RS19490 ENOG4106WHD Tetrathionate reductase GPY59_RS19495 ENOG4105DB1 molybdopterin oxidoreductase GPY59_RS19505 ENOG4105NQN cytochrome C GPY59_RS19510 ENOG4105F1S paraquat-inducible protein a GPY59_RS19515 ENOG4105DY2 Paraquat-inducible protein b GPY59_RS19535 ENOG4108J59 Extracellular solute-binding protein, family 5 GPY59_RS19540 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) GPY59_RS19545 ENOG4105CFV Tetratricopeptide repeat protein GPY59_RS19550 ENOG4105Q4A inner membrane protein yciS GPY59_RS19555 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) GPY59_RS19560 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) GPY59_RS19565 ENOG4105CAT Cytidine monophosphate kinase GPY59_RS19570 ENOG4105ERU peptidase GPY59_RS19575 ENOG4105UBK short-chain dehydrogenase reductase GPY59_RS19590 ENOG4105C0B DNA polymerase III (alpha subunit) GPY59_RS19595 ENOG4107R88 Chemotaxis protein (CheV) GPY59_RS19600 ENOG4105DAG ROK family GPY59_RS19605 ENOG4105CA9 Pyruvate kinase GPY59_RS19610 ENOG4108NRW Phospholipase, patatin family GPY59_RS19625 ENOG4105C8J )-transporter GPY59_RS19640 ENOG4105CI1 PTS System GPY59_RS19645 ENOG4105F8V Hydrolase, tatD family GPY59_RS19650 ENOG4107QRG dna polymerase iii GPY59_RS19655 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) GPY59_RS19660 ENOG4105HHA aminodeoxychorismate lyase GPY59_RS19670 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GPY59_RS19675 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) GPY59_RS19680 ENOG4105CHR reductase GPY59_RS19685 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase GPY59_RS19690 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GPY59_RS19695 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) GPY59_RS19700 ENOG4105VGS 50s ribosomal protein l32 GPY59_RS19705 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein GPY59_RS19710 ENOG4108UHJ MAF-like protein GPY59_RS19715 ENOG4105EI2 Pseudouridine synthase GPY59_RS19720 ENOG4105C03 ribonuclease GPY59_RS19725 ENOG4105CHH sulfate transporter GPY59_RS19730 ENOG4105KJF protein tyrosine phosphatase GPY59_RS19735 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase GPY59_RS19745 ENOG4105DBI uridine monophosphokinase GPY59_RS19750 ENOG4105D1F ATP-binding protein GPY59_RS19755 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) GPY59_RS19765 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) GPY59_RS19775 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) GPY59_RS19780 ENOG4106RHG Yeca family GPY59_RS19785 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) GPY59_RS19790 ENOG4105BZU Histidine kinase GPY59_RS19795 ENOG4107R28 alpha amylase, catalytic region GPY59_RS19800 ENOG4108JJB ABC transporter GPY59_RS19805 ENOG4105C7J ABC transporter, permease GPY59_RS19815 ENOG4105PQ6 UPF0208 membrane protein GPY59_RS19820 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) GPY59_RS19825 ENOG4108DNC Involved in acetate metabolism (By similarity) GPY59_RS19835 ENOG4105CHF Glutathione S-transferase GPY59_RS19840 ENOG4108JQ7 (ABC) transporter GPY59_RS19845 ENOG4105C3U ABC transporter GPY59_RS19850 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GPY59_RS19855 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GPY59_RS19860 ENOG4107QSI ABC, transporter GPY59_RS19865 ENOG4108ZAF Molybdopterin GPY59_RS19870 ENOG4105M00 molybdopterin converting factor, subunit 1 GPY59_RS19875 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GPY59_RS19880 ENOG4108RIR Molybdenum cofactor biosynthesis protein GPY59_RS19885 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GPY59_RS19890 ENOG4105CHW UPF0052 protein GPY59_RS19900 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GPY59_RS19905 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) GPY59_RS19915 ENOG4105C6N Formate acetyltransferase GPY59_RS19920 ENOG4105DGN Electron transport complex GPY59_RS19925 ENOG4108R3D Electron transport complex GPY59_RS19935 ENOG4105D6A Electron transport complex GPY59_RS19940 ENOG4108UQQ Electron transport complex GPY59_RS19945 ENOG4105DZB Electron transport complex GPY59_RS19950 ENOG4105CSM endonuclease III GPY59_RS19955 ENOG4108UYE Lactoylglutathione lyase GPY59_RS19960 ENOG4106WH9 Protein of unknown function (DUF2753) GPY59_RS19965 ENOG4105EIY sodium-type flagellar protein motY GPY59_RS19975 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) GPY59_RS19980 ENOG4105D3Y Na H antiporter GPY59_RS20060 ENOG4105KSC Transcriptional regulator, TraR DksA family GPY59_RS20110 ENOG4105ED4 portal protein GPY59_RS20205 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GPY59_RS20220 ENOG4105M2J Glutaredoxin GPY59_RS20225 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GPY59_RS20245 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein GPY59_RS20250 ENOG4105EYW Ion transport protein GPY59_RS20255 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) GPY59_RS20260 ENOG4105DFD Na H antiporter GPY59_RS20275 ENOG4106V8H Nucleoid-associated protein GPY59_RS20280 ENOG4105YDX UPF0352 protein GPY59_RS20285 ENOG4105E68 Sulfatase GPY59_RS20295 ENOG4105DGU Histone deacetylase GPY59_RS20300 ENOG4108RU0 short-chain dehydrogenase reductase GPY59_RS20310 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) GPY59_RS20315 ENOG41069NU Nitroreductase GPY59_RS20325 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GPY59_RS20330 ENOG4105D07 Signal peptide peptidase, SppA GPY59_RS20335 ENOG4105HDK L-asparaginase GPY59_RS20340 ENOG4105VUT cytoplasmic protein GPY59_RS20350 ENOG4105E0X reductase GPY59_RS20355 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase GPY59_RS20360 ENOG4105DSB aldose 1-epimerase GPY59_RS20365 ENOG4107SDU Methyl-accepting chemotaxis GPY59_RS20370 ENOG4105DHI Methyltransferase GPY59_RS20390 ENOG4105G6Z alkaline phosphatase GPY59_RS20405 ENOG41067V3 Antibiotic biosynthesis monooxygenase GPY59_RS20415 ENOG4108ZZ3 UPF0260 protein GPY59_RS20420 ENOG4105Y3U Transglycosylase-associated protein GPY59_RS20425 ENOG4105KRS Proteinase inhibitor GPY59_RS20430 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) GPY59_RS20435 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) GPY59_RS20440 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) GPY59_RS20445 ENOG4107QMP dna polymerase iii subunits gamma and tau GPY59_RS20450 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) GPY59_RS20455 ENOG4105WD1 Membrane GPY59_RS20465 ENOG4105I93 response regulator GPY59_RS20470 ENOG4105EJC lysr family transcriptional regulator GPY59_RS20475 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase GPY59_RS20480 ENOG4105E96 Colicin v production protein GPY59_RS20485 ENOG4108S3P Sporulation domain protein GPY59_RS20490 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase GPY59_RS20495 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) GPY59_RS20500 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) GPY59_RS20510 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) GPY59_RS20515 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) GPY59_RS20520 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GPY59_RS20525 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) GPY59_RS20530 ENOG4105Q8W reductase GPY59_RS20540 ENOG4105MH2 YfcL protein GPY59_RS20545 ENOG4108BPE -transporting atpase GPY59_RS20555 ENOG4105EN6 Membrane GPY59_RS20560 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase GPY59_RS20565 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) GPY59_RS20570 ENOG4108DG9 Smr protein MutS2 GPY59_RS20575 ENOG4108BY2 phosphohistidine phosphatase GPY59_RS20580 ENOG4107QXK peptidase GPY59_RS20590 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GPY59_RS20595 ENOG4105CHU acetyl-coa acetyltransferase GPY59_RS20610 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation GPY59_RS20615 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation GPY59_RS20620 ENOG410903C (LipO)protein GPY59_RS20625 ENOG4105KWW Biogenesis protein GPY59_RS20630 ENOG4108M1T Cytochrome c-type biogenesis protein GPY59_RS20635 ENOG4107QX9 Thiol disulfide interChange protein GPY59_RS20640 ENOG4105DA4 cytochrome c-type biogenesis protein GPY59_RS20645 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) GPY59_RS20650 ENOG4105X3C heme exporter protein GPY59_RS20655 ENOG41060IM Heme exporter protein GPY59_RS20660 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) GPY59_RS20665 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) GPY59_RS20675 ENOG4108V3W Chemotaxis protein, CheW GPY59_RS20685 ENOG4107QJE Chromosome Partitioning Protein GPY59_RS20690 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) GPY59_RS20695 ENOG4105CBS Chea signal transduction histidine kinase GPY59_RS20700 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) GPY59_RS20705 ENOG4108VYJ response regulator receiver protein GPY59_RS20710 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GPY59_RS20715 ENOG4107R21 site-determining protein GPY59_RS20720 ENOG4105FZW flagellar biosynthesis regulator FlhF GPY59_RS20725 ENOG4105D7B Flagellar biosynthesis protein flha GPY59_RS20730 ENOG4105D00 flagellar biosynthetic protein flhB GPY59_RS20735 ENOG4105D19 Role in flagellar biosynthesis (By similarity) GPY59_RS20740 ENOG4105VS8 Flagellar biosynthetic protein fliq GPY59_RS20745 ENOG4105CN7 Flagellar biosynthetic protein FliP GPY59_RS20750 ENOG4105VTB flagellar biosynthesis protein fliO GPY59_RS20755 ENOG4105DD5 Flagellar motor switch protein GPY59_RS20760 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) GPY59_RS20785 ENOG4108JIR Flagellum-specific ATP synthase GPY59_RS20795 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) GPY59_RS20800 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) GPY59_RS20805 ENOG4105VQ0 flagellar hook-basal body complex protein fliE GPY59_RS20810 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GPY59_RS20815 ENOG4105BZU Histidine kinase GPY59_RS20820 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GPY59_RS20825 ENOG4105MQ3 flagellar protein FliS GPY59_RS20835 ENOG4107BRV flagellar capping protein GPY59_RS20840 ENOG41063QE flagellar protein FlaG GPY59_RS20845 ENOG4105I03 Flagellin GPY59_RS20850 ENOG4105I03 Flagellin GPY59_RS20860 ENOG4105I03 Flagellin GPY59_RS20865 ENOG4105EZR dyp-type peroxidase family protein GPY59_RS20870 ENOG4105QZU Inner membrane protein YfeZ GPY59_RS20890 ENOG4105KUZ arsenate reductase GPY59_RS20895 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) GPY59_RS20910 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) GPY59_RS20925 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GPY59_RS20940 ENOG4105ERG peptidase m48, ste24p GPY59_RS20945 ENOG4105K89 arsenate reductase GPY59_RS20950 ENOG4105CS1 NAD(P)H quinone oxidoreductase GPY59_RS20965 ENOG4105C2W permease GPY59_RS20975 ENOG4105CXB phosphoribosylaminoimidazole synthetase GPY59_RS20980 ENOG4108V3E phosphoribosylglycinamide formyltransferase GPY59_RS20985 ENOG4105E7A Glutamine amidotransferase GPY59_RS20990 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) GPY59_RS20995 ENOG4107QPN acyl-Coa dehydrogenase GPY59_RS21025 ENOG4108JDX DNA polymerase iii, epsilon subunit GPY59_RS21030 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GPY59_RS21035 ENOG4105D1A Methyltransferase GPY59_RS21040 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) GPY59_RS21045 ENOG4105E9H Lytic Murein transglycosylase GPY59_RS21055 ENOG4107NA1 Endonuclease Exonuclease phosphatase GPY59_RS21060 ENOG4108YZA Nitrogen regulatory protein pii GPY59_RS21065 ENOG4105N7H Cytochrome GPY59_RS21070 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) GPY59_RS21075 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) GPY59_RS21080 ENOG4105C0B DNA polymerase III (alpha subunit) GPY59_RS21085 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GPY59_RS21090 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) GPY59_RS21095 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) GPY59_RS21100 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) GPY59_RS21105 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) GPY59_RS21110 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) GPY59_RS21120 ENOG4105DZP Membrane-associated zinc metalloprotease GPY59_RS21125 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) GPY59_RS21130 ENOG4105KNE Phosphatidate cytidylyltransferase GPY59_RS21135 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) GPY59_RS21140 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) GPY59_RS21145 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) GPY59_RS21150 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) GPY59_RS21155 ENOG4105CE9 30S ribosomal protein S2 GPY59_RS21160 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) GPY59_RS21165 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) GPY59_RS21170 ENOG4108T8E UPF0325 protein GPY59_RS21175 ENOG4105DR9 pseudouridine synthase GPY59_RS21180 ENOG4105DR9 pseudouridine synthase GPY59_RS21205 ENOG4108UPT UPF0178 protein GPY59_RS21210 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GPY59_RS21215 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase GPY59_RS21240 ENOG4105CFC Transporter GPY59_RS21250 ENOG4105NRA 50s ribosomal protein l31 type b GPY59_RS21255 ENOG4108R96 Methyltransferase, YaeB family GPY59_RS21260 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) GPY59_RS21270 ENOG4105W1I UPF0253 protein GPY59_RS21280 ENOG4105C8J )-transporter GPY59_RS21295 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) GPY59_RS21300 ENOG4105C9U ATP-dependent DNA helicase RecQ GPY59_RS21305 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) GPY59_RS21315 ENOG4105BZU Histidine kinase GPY59_RS21325 ENOG4105CJ2 (LipO)protein GPY59_RS21330 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) GPY59_RS21335 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) GPY59_RS21340 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) GPY59_RS21345 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) GPY59_RS21350 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) GPY59_RS21355 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) GPY59_RS21360 ENOG4105M85 Bola protein GPY59_RS21365 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) GPY59_RS21370 ENOG4105IEY (LipO)protein GPY59_RS21375 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) GPY59_RS21390 ENOG4105K6V RNA polymerase GPY59_RS21410 ENOG4105DRB nucleoside-specific channel-forming protein GPY59_RS21415 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) GPY59_RS21420 ENOG4107S0N DJ-1 family GPY59_RS21425 ENOG4105C9B Cysteine desulfurase GPY59_RS21430 ENOG4105BZU Histidine kinase GPY59_RS21435 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) GPY59_RS21440 ENOG4105CUZ uba thif-type nad fad binding protein GPY59_RS21445 ENOG4105CA3 membrane-bound lytic murein transglycosylase GPY59_RS21455 ENOG4107QZM n-acetylglutamate synthase GPY59_RS21465 ENOG4107QYX exodeoxyribonuclease v alpha GPY59_RS21470 ENOG4107QKA exodeoxyribonuclease V beta GPY59_RS21475 ENOG4105DSY exodeoxyribonuclease V, gamma GPY59_RS21480 ENOG4105E68 Sulfatase GPY59_RS21490 ENOG4105EVZ LysR family transcriptional regulator GPY59_RS21495 ENOG4105X2V dna damage-inducible protein GPY59_RS21510 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) GPY59_RS21515 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase GPY59_RS21520 ENOG4105CXY transporter GPY59_RS21530 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) GPY59_RS21535 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) GPY59_RS21540 ENOG4105E98 transcriptional regulator DeoR family GPY59_RS21545 ENOG4105C6V Glycerol-3-phosphate dehydrogenase GPY59_RS21550 ENOG4107RX3 Mg2 transporter protein cora family protein GPY59_RS21570 ENOG4105CQ4 Transcriptional regulator GPY59_RS21575 ENOG41064T2 transcriptional regulator, lysR family GPY59_RS21585 ENOG41086KC Transcriptional regulator GPY59_RS21615 ENOG4108IQE Amp-dependent synthetase and ligase GPY59_RS21625 ENOG4105ETT transcriptional Regulator, LysR family GPY59_RS21630 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) GPY59_RS21635 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) GPY59_RS21645 ENOG4105EAC phosphoserine phosphatase GPY59_RS21655 ENOG4105D3A purine nucleoside phosphorylase DeoD-type GPY59_RS21660 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) GPY59_RS21665 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) GPY59_RS21670 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) GPY59_RS21675 ENOG4105D9N nucleoside GPY59_RS21680 ENOG4105EYA deoxyribonuclease GPY59_RS21690 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) GPY59_RS21710 ENOG4108YYD acetyltransferase GPY59_RS21715 ENOG4105XPQ lipid carrier protein GPY59_RS21720 ENOG4105BZU Histidine kinase GPY59_RS21725 ENOG4105CFP Peptidase U32 GPY59_RS21730 ENOG4106RZ4 Peptidase U32 GPY59_RS21735 ENOG4105C3S Mate efflux family protein GPY59_RS21750 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) GPY59_RS21755 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) GPY59_RS21760 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) GPY59_RS21765 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) GPY59_RS21770 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) GPY59_RS21775 ENOG4105CHV Transcription elongation factor NusA GPY59_RS21780 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) GPY59_RS21805 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) GPY59_RS21810 ENOG4105EEI dihydropteroate synthase GPY59_RS21815 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) GPY59_RS21820 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) GPY59_RS21825 ENOG4105HBR Rna-binding protein GPY59_RS21830 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) GPY59_RS21835 ENOG4107QE9 Inherit from COG: Membrane GPY59_RS21840 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase GPY59_RS21850 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) GPY59_RS21855 ENOG4105DR5 peptidase GPY59_RS21870 ENOG4108YX9 iron--sulfur cluster insertion protein erpA GPY59_RS21875 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase GPY59_RS21880 ENOG4105F4G Membrane GPY59_RS21885 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) GPY59_RS21890 ENOG4105BZU Histidine kinase GPY59_RS21895 ENOG4107QRA Extracellular solute-binding protein, family 5 GPY59_RS21905 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GPY59_RS21910 ENOG4105C3U ABC transporter GPY59_RS21915 ENOG4108JQ7 (ABC) transporter GPY59_RS21925 ENOG4105RD7 BadF BadG BcrA BcrD GPY59_RS21930 ENOG4105E2D ec 3.2.1.52 GPY59_RS21945 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GPY59_RS21965 ENOG4108YZA Nitrogen regulatory protein pii GPY59_RS21970 ENOG4105XTV UPF0231 protein GPY59_RS21975 ENOG4107QIJ Aconitate hydratase 2 GPY59_RS21980 ENOG4105D78 K07001 NTE family protein GPY59_RS21985 ENOG4105BZ4 penicillin-binding protein GPY59_RS21990 ENOG4105CQ7 ATP-dependent helicase GPY59_RS21995 ENOG4105PW4 Sugar fermentation stimulation protein homolog GPY59_RS22000 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters GPY59_RS22005 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) GPY59_RS22010 ENOG4105DJ0 Poly(A) Polymerase GPY59_RS22015 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase GPY59_RS22020 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) GPY59_RS22025 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) GPY59_RS22030 ENOG4105D1S lipid A biosynthesis GPY59_RS22035 ENOG4105E3A (ABC) transporter GPY59_RS22040 ENOG4105DA5 (ABC) transporter GPY59_RS22045 ENOG4105CHH sulfate transporter GPY59_RS22050 ENOG41077A9 carbonic anhydrase GPY59_RS22055 ENOG4108UGV hypoxanthine phosphoribosyltransferase GPY59_RS22060 ENOG410630P Transcriptional regulator GPY59_RS22065 ENOG4107QN2 dihydrolipoyl dehydrogenase GPY59_RS22070 ENOG4107QSN dihydrolipoamide acetyltransferase GPY59_RS22075 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) GPY59_RS22080 ENOG41073TP transcriptional regulator GPY59_RS22090 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase GPY59_RS22100 ENOG4107QHF type ii secretion system protein e GPY59_RS22105 ENOG4105D7Q type ii secretion system GPY59_RS22110 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) GPY59_RS22115 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) GPY59_RS22120 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) GPY59_RS22125 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) GPY59_RS22130 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) GPY59_RS22135 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) GPY59_RS22140 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) GPY59_RS22145 ENOG4105K5M 30s ribosomal protein S16 GPY59_RS22150 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY GPY59_RS22155 ENOG4106KVJ cytochrome C assembly protein GPY59_RS22160 ENOG4108JU6 CBS domain protein GPY59_RS22175 ENOG4105D9M gamma-glutamylcysteine synthetase GPY59_RS22185 ENOG4105W39 Membrane GPY59_RS22195 ENOG4105D9Q decarboxylase (Beta subunit) GPY59_RS22200 ENOG4107QSA Oxaloacetate decarboxylase GPY59_RS22260 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) GPY59_RS22265 ENOG4105CFH Aspartokinase GPY59_RS22270 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) GPY59_RS22275 ENOG4105Y3E Modulates RecA activity (By similarity) GPY59_RS22285 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) GPY59_RS22290 ENOG4107TH8 cina domain protein GPY59_RS22295 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) GPY59_RS22300 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GPY59_RS22310 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) GPY59_RS22315 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) GPY59_RS22320 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) GPY59_RS22325 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) GPY59_RS22330 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) GPY59_RS22335 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) GPY59_RS22340 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) GPY59_RS22345 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) GPY59_RS22350 ENOG4105DXN mazG family GPY59_RS22355 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) GPY59_RS22365 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) GPY59_RS22370 ENOG4105BZU Histidine kinase GPY59_RS22375 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) GPY59_RS22380 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) GPY59_RS22385 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) GPY59_RS22390 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) GPY59_RS22395 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) GPY59_RS22400 ENOG4105C3F Signal peptidase i GPY59_RS22405 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) GPY59_RS22425 ENOG4105EMN RNA polymerase sigma factor GPY59_RS22435 ENOG4108IYU L-aspartate oxidase GPY59_RS22440 ENOG4105Y75 tpr repeat protein GPY59_RS22445 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) GPY59_RS22460 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family GPY59_RS22465 ENOG4105D0A hydroxylase GPY59_RS22480 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) GPY59_RS22490 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase GPY59_RS22495 ENOG4105E66 phosphoriboisomerase A GPY59_RS22500 ENOG4108JQ1 Dehydrogenase GPY59_RS22505 ENOG4105MPN Membrane GPY59_RS22510 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) GPY59_RS22525 ENOG4105D64 Mechanosensitive ion channel GPY59_RS22530 ENOG4105D2N Aldolase GPY59_RS22535 ENOG4105BZA Phosphoglycerate kinase GPY59_RS22540 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase GPY59_RS22545 ENOG4105D05 Receptor GPY59_RS22550 ENOG4108R4R Iron-regulated virulence regulatory protein GPY59_RS22555 ENOG4105CV1 Transketolase (EC 2.2.1.1) GPY59_RS22565 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP GPY59_RS22575 ENOG4105GPY SprT protein GPY59_RS22580 ENOG4105RWS endonuclease I GPY59_RS22585 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) GPY59_RS22590 ENOG4105D7Z glutathione synthase GPY59_RS22595 ENOG4108UJU UPF0301 protein GPY59_RS22600 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) GPY59_RS22605 ENOG4105CZX twitching motility protein GPY59_RS22610 ENOG4105CZX twitching motility protein GPY59_RS22615 ENOG4105DFA alanine racemase domain protein GPY59_RS22620 ENOG4105II7 pyrroline-5-carboxylate reductase GPY59_RS22625 ENOG4108VIA integral membrane protein GPY59_RS22630 ENOG4105VZ9 UPF0235 protein GPY59_RS22640 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) GPY59_RS22645 ENOG4105CSA Coproporphyrinogen iii oxidase GPY59_RS22650 ENOG4105CSV Glutaminase GPY59_RS22660 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) GPY59_RS22665 ENOG4105CEN a g-specific adenine glycosylase GPY59_RS22670 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) GPY59_RS22715 ENOG4105C8Q Methyl-accepting chemotaxis GPY59_RS22790 ENOG4108ESY Metal dependent phosphohydrolase GPY59_RS22795 ENOG4105ETE Transcriptional regulator (LacI family GPY59_RS22800 ENOG410901P UPF0249 protein GPY59_RS22805 ENOG4105F8D glycoside hydrolase family 4 GPY59_RS22810 ENOG4105VCP PTS System GPY59_RS22815 ENOG4105CK1 PTS System GPY59_RS22870 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GPY59_RS22935 ENOG41061TZ Short-chain dehydrogenase reductase Sdr GPY59_RS22940 ENOG4105EXU Membrane GPY59_RS22950 ENOG4108K5H permease YjgP YjgQ family protein GPY59_RS22955 ENOG4108M8S permease YjgP YjgQ family protein GPY59_RS22960 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) GPY59_RS22965 ENOG4105MYG DNA polymerase iii, chi subunit GPY59_RS22970 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) GPY59_RS22980 ENOG4108MJ3 acetyltransferase GPY59_RS22995 ENOG4105CEU Arginine dihydrolase GPY59_RS23000 ENOG4105DBV ornithine carbamoyltransferase GPY59_RS23010 ENOG4105CXT aspartate transcarbamylase GPY59_RS23015 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) GPY59_RS23020 ENOG4105KME endoribonuclease L-psp GPY59_RS23025 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase GPY59_RS23030 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) GPY59_RS23035 ENOG4105VFK BolA family GPY59_RS23045 ENOG4105E3I toluene tolerance GPY59_RS23050 ENOG4107PE3 Mammalian cell entry related domain protein GPY59_RS23055 ENOG4105CY3 ABC transporter, permease GPY59_RS23060 ENOG4105DHJ ABC, transporter GPY59_RS23070 ENOG4105C2X Arabinose 5-phosphate isomerase GPY59_RS23080 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA GPY59_RS23085 ENOG4108IUZ ABC transporter GPY59_RS23090 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GPY59_RS23095 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA GPY59_RS23100 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN GPY59_RS23105 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) GPY59_RS23110 ENOG41080Z8 PHOSPHOCARRIER protein GPY59_RS23115 ENOG4105CJW magnesium transporter GPY59_RS23120 ENOG4105CMS peptidase U62, modulator of DNA gyrase GPY59_RS23125 ENOG4105N42 UPF0307 protein GPY59_RS23130 ENOG4105C5I Dehydrogenase GPY59_RS23135 ENOG4105D3G Pseudouridine synthase GPY59_RS23140 ENOG4105K3M )-transporter GPY59_RS23145 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) GPY59_RS23150 ENOG4108IAB Phoh family GPY59_RS23155 ENOG4105D1U peptidase U62 modulator of DNA gyrase GPY59_RS23165 ENOG4105QD6 exported protein GPY59_RS23170 ENOG4105C03 ribonuclease GPY59_RS23175 ENOG4108Z03 MAF-like protein GPY59_RS23180 ENOG4105VQ7 Rod shape-determining protein MreD GPY59_RS23185 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) GPY59_RS23190 ENOG4105DFF Rod shape-determining protein mreb GPY59_RS23235 ENOG4105D7Q type ii secretion system GPY59_RS23240 ENOG4107QHF type ii secretion system protein e GPY59_RS23275 ENOG41062P1 Diguanylate cyclase phosphodiesterase GPY59_RS23280 ENOG4108UUM single-stranded DNA-binding protein GPY59_RS23285 ENOG41086KC Transcriptional regulator GPY59_RS23290 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase GPY59_RS23295 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) GPY59_RS23305 ENOG4105C5R Aminotransferase GPY59_RS23310 ENOG4105CFH Aspartokinase GPY59_RS23315 ENOG4105C3R Methionine synthase GPY59_RS23320 ENOG4105EEQ Na H antiporter GPY59_RS23370 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) GPY59_RS23375 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) GPY59_RS23380 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) GPY59_RS23400 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) GPY59_RS23405 ENOG4105MYN Zinc uptake regulation protein GPY59_RS23415 ENOG4107QP8 phosphohexose isomerase GPY59_RS23420 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme GPY59_RS23425 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) GPY59_RS23430 ENOG4105CDU Replicative dna helicase GPY59_RS23440 ENOG4105K9Q Binds to the 23S rRNA (By similarity) GPY59_RS23445 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) GPY59_RS23450 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) GPY59_RS23455 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) GPY59_RS23460 ENOG4105DJV ribulose-phosphate 3-epimerase GPY59_RS23465 ENOG4105DFE Dna adenine methylase GPY59_RS23475 ENOG4105D49 3-dehydroquinate synthase GPY59_RS23480 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) GPY59_RS23485 ENOG4105E4G Type IV pilus GPY59_RS23510 ENOG4108JQC penicillin-binding protein 1A GPY59_RS23515 ENOG4105C5Q Transcriptional regulator GPY59_RS23520 ENOG4105EHV domain protein GPY59_RS23525 ENOG4107QN2 dihydrolipoyl dehydrogenase GPY59_RS23535 ENOG4105CH7 arginosuccinase GPY59_RS23540 ENOG4105CDH Citrulline--aspartate ligase GPY59_RS23545 ENOG4105CAS nag kinase GPY59_RS23550 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase GPY59_RS23555 ENOG4105CWC Acetylornithine deacetylase GPY59_RS23560 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) GPY59_RS23570 ENOG4105SYT Methylenetetrahydrofolate reductase GPY59_RS23575 ENOG4105CFH Aspartokinase GPY59_RS23580 ENOG4105C28 cystathionine GPY59_RS23585 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) GPY59_RS23590 ENOG4105C6K Malic enzyme GPY59_RS23595 ENOG4108UQY Iron-storage protein GPY59_RS23600 ENOG4105W53 bacterioferritin-associated ferredoxin GPY59_RS23605 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) GPY59_RS23610 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) GPY59_RS23615 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) GPY59_RS23620 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) GPY59_RS23630 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) GPY59_RS23635 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) GPY59_RS23640 ENOG4105WWK YheO domain protein GPY59_RS23645 ENOG4108V1T peptidylprolyl cis-trans isomerase GPY59_RS23655 ENOG41069P5 Protein slyX homolog GPY59_RS23660 ENOG4105D44 asparaginase GPY59_RS23670 ENOG4108YZY peptidylprolyl cis-trans isomerase GPY59_RS23685 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein GPY59_RS23690 ENOG4105C5H ABC transporter GPY59_RS23700 ENOG4105DNZ Alpha Beta Hydrolase GPY59_RS23705 ENOG4105YP7 UPF0270 protein GPY59_RS23710 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) GPY59_RS23715 ENOG4107RYR Transcriptional regulator, Crp Fnr family GPY59_RS23725 ENOG4105C26 Dehydrogenase GPY59_RS23735 ENOG4105C8Y Acetylornithine aminotransferase GPY59_RS23740 ENOG4105DDQ anthranilate synthase GPY59_RS23755 ENOG4105C31 Tryptophanyl-tRNA synthetase GPY59_RS23760 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) GPY59_RS23765 ENOG4105C2N RNA methyltransferase TrmH family group 3 GPY59_RS23770 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) GPY59_RS23775 ENOG4105KPV Transcriptional regulator GPY59_RS23780 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) GPY59_RS23785 ENOG4108UV7 flagellar protein motX GPY59_RS23795 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis GPY59_RS23805 ENOG4105EPW hflc protein GPY59_RS23810 ENOG4107QJR hflk protein GPY59_RS23815 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) GPY59_RS23820 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) GPY59_RS23825 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) GPY59_RS23830 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) GPY59_RS23835 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase GPY59_RS23840 ENOG4105K8N protein family UPF0079, ATPase GPY59_RS23845 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) GPY59_RS23910 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) GPY59_RS23915 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) GPY59_RS23920 ENOG4105DJ4 phosphatidylserine decarboxylase GPY59_RS23925 ENOG4105C8P )-transporter GPY59_RS23935 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) GPY59_RS23940 ENOG4107YZP Rhodanese domain protein GPY59_RS23945 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) GPY59_RS23950 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase GPY59_RS23955 ENOG4105D7W serine acetyltransferase GPY59_RS23960 ENOG41063SB peptidase GPY59_RS23970 ENOG41062JF Transcriptional regulator GPY59_RS23980 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) GPY59_RS23990 ENOG4105E33 succinate dehydrogenase GPY59_RS23995 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) GPY59_RS24000 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) GPY59_RS24010 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) GPY59_RS24015 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein GPY59_RS24020 ENOG4105KT7 mgtC SapB transporter GPY59_RS24030 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) GPY59_RS24035 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) GPY59_RS24040 ENOG4107QI1 Mate efflux family protein GPY59_RS24045 ENOG4105CTQ phosphohexokinase GPY59_RS24050 ENOG41076HS cation diffusion facilitator family transporter GPY59_RS24055 ENOG4108SPG Periplasmic Protein GPY59_RS24060 ENOG4105E3W Two component transcriptional regulator (Winged helix family GPY59_RS24065 ENOG4105E0F Histidine kinase GPY59_RS24075 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) GPY59_RS24080 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 GPY59_RS24085 ENOG4108IJ0 Aspartate ammonia-lyase GPY59_RS24090 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter GPY59_RS24095 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) GPY59_RS24105 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) GPY59_RS24115 ENOG4107QN1 sodium solute GPY59_RS24130 ENOG4105C9Q fumarate hydratase class II GPY59_RS24135 ENOG4105BZU Histidine kinase GPY59_RS24140 ENOG4105D8G Major Facilitator superfamily GPY59_RS24155 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GPY59_RS24160 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) GPY59_RS24165 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein GPY59_RS24170 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase GPY59_RS24175 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) GPY59_RS24180 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) GPY59_RS24185 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) GPY59_RS24195 ENOG4105C5H ABC transporter GPY59_RS24250 ENOG4105CXN decarboxylase GPY59_RS24255 ENOG4105D5Q Arginine ornithine antiporter GPY59_RS24265 ENOG4108M3R transcriptional activator CadC GPY59_RS24280 ENOG4105DC1 bifunctional purine biosynthesis protein purh GPY59_RS24285 ENOG4105C12 Phosphoribosylglycinamide synthetase GPY59_RS24305 ENOG4105R2J Conserved Protein GPY59_RS24310 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase GPY59_RS24315 ENOG4108RG0 uracil-dna glycosylase GPY59_RS24320 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) GPY59_RS24325 ENOG4105E09 nadh pyrophosphatase GPY59_RS24330 ENOG4108ZVW Anti-RNA polymerase sigma 70 factor GPY59_RS24335 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GPY59_RS24340 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GPY59_RS24345 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) GPY59_RS24350 ENOG4108VZM 50s ribosomal protein L10 GPY59_RS24355 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) GPY59_RS24360 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) GPY59_RS24365 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) GPY59_RS24370 ENOG4105PM1 preprotein translocase subunit SecE GPY59_RS24380 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) GPY59_RS24405 ENOG4105CS9 pantothenic acid kinase GPY59_RS24410 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase GPY59_RS24415 ENOG4105D4A Cell wall formation (By similarity) GPY59_RS24425 ENOG4105JIM Phosphatidylserine synthase GPY59_RS24505 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) GPY59_RS24525 ENOG4107QJE Chromosome Partitioning Protein GPY59_RS24610 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) GPY59_RS24700 ENOG4105T95 Thiol disulfide interChange protein GPY59_RS24760 ENOG4105GMT ATPase associated with various cellular activities aaa_5 GPY59_RS24770 ENOG4108UUM single-stranded DNA-binding protein GPY59_RS24815 ENOG4105XPH Ferredoxin GPY59_RS24975 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GPY59_RS25120 ENOG4105D07 Signal peptide peptidase, SppA GPY59_RS25165 ENOG4105K70 DNA-binding protein GPY59_RS25330 ENOG4107QJE Chromosome Partitioning Protein GPY59_RS25335 ENOG4105FA0 parb-like partition protein GPY59_RS25375 ENOG41068G1 GPY59_RS25445 ENOG4108N8Y HfaB protein GPY59_RS25545 ENOG4105UYK outer membrane protein a GPY59_RS25560 ENOG4108JJA ABC, transporter GPY59_RS25585 ENOG4108W0I acetyltransferase GPY59_RS25590 ENOG4108R4U Hnh endonuclease GPY59_RS25635 ENOG4105BZU Histidine kinase GPY59_RS25640 ENOG4105BZU Histidine kinase GPY59_RS25900 ENOG4105H9W Short-chain dehydrogenase reductase Sdr GPY59_RS25985 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) GPY59_RS26045 ENOG4108UUM single-stranded DNA-binding protein