locus-tag	class	description
GPY59_RS00005	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY59_RS00020	COG0546	phosphoglycolate phosphatase activity
GPY59_RS00025	COG0840	transmembrane signaling receptor activity
GPY59_RS00035	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
GPY59_RS00040	COG0513	Belongs to the DEAD box helicase family
GPY59_RS00060	COG3038	cytochrome b561
GPY59_RS00065	COG2353	YceI-like domain
GPY59_RS00070	COG2116	formate transmembrane transporter activity
GPY59_RS00075	COG0583	DNA-binding transcription factor activity
GPY59_RS00085	COG3593	DNA synthesis involved in DNA repair
GPY59_RS00090	COG0737	Belongs to the 5'-nucleotidase family
GPY59_RS00115	COG2267	carboxylic ester hydrolase activity
GPY59_RS00120	COG2067	long-chain fatty acid transport protein
GPY59_RS00135	COG2050	protein possibly involved in aromatic compounds catabolism
GPY59_RS00145	COG4533	DNA binding
GPY59_RS00180	COG5001	Diguanylate cyclase
GPY59_RS00180	COG3300	MHYT domain
GPY59_RS00185	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GPY59_RS00195	COG4181	ATPase activity
GPY59_RS00200	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GPY59_RS00210	COG1984	allophanate hydrolase subunit 2
GPY59_RS00215	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GPY59_RS00220	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GPY59_RS00225	COG3447	MASE1 domain protein
GPY59_RS00225	COG5001	Diguanylate cyclase
GPY59_RS00225	COG5002	protein histidine kinase activity
GPY59_RS00245	COG0583	DNA-binding transcription factor activity
GPY59_RS00250	COG1042	CoA-binding domain protein
GPY59_RS00250	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY59_RS00250	COG0045	succinate-CoA ligase (ADP-forming) activity
GPY59_RS00260	COG1181	Belongs to the D-alanine--D-alanine ligase family
GPY59_RS00270	COG0023	Translation Initiation Factor
GPY59_RS00430	COG0583	DNA-binding transcription factor activity
GPY59_RS00445	COG3140	Belongs to the UPF0181 family
GPY59_RS00470	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GPY59_RS00475	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GPY59_RS00490	COG0745	RESPONSE REGULATOR receiver
GPY59_RS00490	COG3706	GGDEF domain
GPY59_RS00495	COG5001	Diguanylate cyclase
GPY59_RS00495	COG4251	negative regulation of phosphorylation
GPY59_RS00495	COG3706	GGDEF domain
GPY59_RS00495	COG2203	Gaf domain
GPY59_RS00505	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GPY59_RS00510	COG4149	molybdate abc transporter
GPY59_RS00515	COG0725	ABC transporter, periplasmic molybdate-binding protein
GPY59_RS00525	COG3111	PFAM Bacterial OB fold (BOF) protein
GPY59_RS00535	COG0189	ligase activity
GPY59_RS00535	COG4067	protein conserved in archaea
GPY59_RS00545	COG2207	Transcriptional regulator
GPY59_RS00550	COG0534	Mate efflux family protein
GPY59_RS00555	COG0602	queuosine metabolic process
GPY59_RS00560	COG1328	CTP reductase activity
GPY59_RS00590	COG1794	racemase activity, acting on amino acids and derivatives
GPY59_RS00595	COG0384	phenazine biosynthesis protein PhzF
GPY59_RS00610	COG0243	molybdopterin cofactor binding
GPY59_RS00620	COG0583	DNA-binding transcription factor activity
GPY59_RS00625	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GPY59_RS00635	COG2197	response regulator
GPY59_RS00640	COG3851	Histidine kinase
GPY59_RS00645	COG2271	Major facilitator Superfamily
GPY59_RS00670	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GPY59_RS00675	COG3118	belongs to the thioredoxin family
GPY59_RS00680	COG2814	Major facilitator Superfamily
GPY59_RS00710	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GPY59_RS00730	COG2116	formate transmembrane transporter activity
GPY59_RS00735	COG2146	nitrite reductase [NAD(P)H] activity
GPY59_RS00740	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GPY59_RS00745	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY59_RS00765	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GPY59_RS00815	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPY59_RS00830	COG0277	FAD linked oxidase domain protein
GPY59_RS00835	COG0583	DNA-binding transcription factor activity
GPY59_RS00850	COG2425	protein containing a von Willebrand factor type A (vWA) domain
GPY59_RS00865	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
GPY59_RS00875	COG1288	antiporter activity
GPY59_RS00885	COG3040	lipid binding
GPY59_RS00895	COG0419	ATPase involved in DNA repair
GPY59_RS00900	COG0420	3'-5' exonuclease activity
GPY59_RS00915	COG3501	Rhs element vgr protein
GPY59_RS00970	COG0631	protein serine/threonine phosphatase activity
GPY59_RS01005	COG0515	serine threonine protein kinase
GPY59_RS01005	COG2815	serine threonine protein kinase
GPY59_RS01055	COG2146	nitrite reductase [NAD(P)H] activity
GPY59_RS01055	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GPY59_RS01060	COG1116	anion transmembrane transporter activity
GPY59_RS01065	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GPY59_RS01070	COG1116	anion transmembrane transporter activity
GPY59_RS01070	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GPY59_RS01080	COG3707	response regulator
GPY59_RS01095	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GPY59_RS01095	COG1648	precorrin-2 dehydrogenase activity
GPY59_RS01100	COG0243	molybdopterin cofactor binding
GPY59_RS01110	COG0814	amino acid
GPY59_RS01120	COG3706	GGDEF domain
GPY59_RS01175	COG2847	Copper chaperone PCu(A)C
GPY59_RS01180	COG0443	Heat shock 70 kDa protein
GPY59_RS01250	COG4160	amino acid transport
GPY59_RS01255	COG4215	(ABC) transporter
GPY59_RS01260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY59_RS01265	COG1126	abc transporter atp-binding protein
GPY59_RS01295	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPY59_RS01305	COG1012	belongs to the aldehyde dehydrogenase family
GPY59_RS01320	COG0446	pyridine nucleotide-disulphide oxidoreductase
GPY59_RS01320	COG1902	pentaerythritol trinitrate reductase activity
GPY59_RS01325	COG0109	protoheme IX farnesyltransferase activity
GPY59_RS01330	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GPY59_RS01335	COG1845	cytochrome c oxidase, subunit III
GPY59_RS01340	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GPY59_RS01345	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GPY59_RS01350	COG1028	Short-chain dehydrogenase reductase Sdr
GPY59_RS01360	COG1024	Enoyl-CoA hydratase
GPY59_RS01365	COG1024	Enoyl-CoA hydratase
GPY59_RS01380	COG0183	Belongs to the thiolase family
GPY59_RS01390	COG1960	acyl-CoA dehydrogenase activity
GPY59_RS01395	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GPY59_RS01400	COG1024	Enoyl-CoA hydratase
GPY59_RS01425	COG2095	MarC family integral membrane protein
GPY59_RS01430	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GPY59_RS01440	COG0523	cobalamin synthesis protein
GPY59_RS01445	COG0739	heme binding
GPY59_RS01450	COG2988	succinylglutamate desuccinylase activity
GPY59_RS01455	COG0523	cobalamin synthesis protein
GPY59_RS01465	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GPY59_RS01470	COG0735	belongs to the Fur family
GPY59_RS01485	COG0730	response to heat
GPY59_RS01500	COG1073	alpha beta
GPY59_RS01505	COG1073	alpha beta
GPY59_RS01515	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GPY59_RS01530	COG0513	Belongs to the DEAD box helicase family
GPY59_RS01535	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
GPY59_RS01550	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GPY59_RS01570	COG1119	ATPase activity
GPY59_RS01575	COG2200	EAL domain
GPY59_RS01595	COG0513	Belongs to the DEAD box helicase family
GPY59_RS01600	COG0523	cobalamin synthesis protein
GPY59_RS01610	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
GPY59_RS01620	COG1278	Cold shock
GPY59_RS01630	COG0133	tryptophan synthase activity
GPY59_RS01640	COG4628	conserved protein (DUF2132)
GPY59_RS01645	COG0513	Belongs to the DEAD box helicase family
GPY59_RS01655	COG4589	Belongs to the CDS family
GPY59_RS01680	COG3530	Putative quorum-sensing-regulated virulence factor
GPY59_RS01705	COG3186	Phenylalanine-4-hydroxylase
GPY59_RS01710	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPY59_RS01715	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPY59_RS01735	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
GPY59_RS01740	COG1454	alcohol dehydrogenase
GPY59_RS01745	COG2133	pyrroloquinoline quinone binding
GPY59_RS01755	COG0783	Belongs to the Dps family
GPY59_RS01760	COG0840	transmembrane signaling receptor activity
GPY59_RS01785	COG0784	Response regulator, receiver
GPY59_RS01785	COG2205	protein histidine kinase activity
GPY59_RS01790	COG1538	Outer membrane efflux protein
GPY59_RS01800	COG1132	(ABC) transporter
GPY59_RS01815	COG2199	diguanylate cyclase activity
GPY59_RS01820	COG3036	rescue of stalled ribosome
GPY59_RS01825	COG1278	Cold shock
GPY59_RS01855	COG0545	Peptidyl-prolyl cis-trans isomerase
GPY59_RS01860	COG0109	protoheme IX farnesyltransferase activity
GPY59_RS01865	COG1612	heme a metabolic process
GPY59_RS01885	COG1845	cytochrome c oxidase, subunit III
GPY59_RS01890	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
GPY59_RS01900	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GPY59_RS01905	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPY59_RS01915	COG1280	lysine exporter protein (LysE YggA)
GPY59_RS01935	COG0179	Fumarylacetoacetate (FAA) hydrolase
GPY59_RS01950	COG0697	spore germination
GPY59_RS01970	COG2814	Major facilitator Superfamily
GPY59_RS01975	COG0583	DNA-binding transcription factor activity
GPY59_RS01980	COG5001	Diguanylate cyclase
GPY59_RS01985	COG0739	heme binding
GPY59_RS02025	COG0814	amino acid
GPY59_RS02050	COG4989	oxidoreductase activity
GPY59_RS02095	COG1358	cellular component organization or biogenesis
GPY59_RS02120	COG1733	regulation of RNA biosynthetic process
GPY59_RS02135	COG0798	PFAM Bile acid sodium symporter
GPY59_RS02145	COG1881	PFAM PEBP family protein
GPY59_RS02160	COG1131	(ABC) transporter
GPY59_RS02165	COG0842	Transport permease protein
GPY59_RS02175	COG3383	formate dehydrogenase (NAD+) activity
GPY59_RS02195	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY59_RS02220	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY59_RS02230	COG2067	long-chain fatty acid transport protein
GPY59_RS02240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY59_RS02250	COG1505	serine-type exopeptidase activity
GPY59_RS02255	COG0488	(ABC) transporter
GPY59_RS02260	COG0589	response to stress
GPY59_RS02265	COG2249	NAD(P)H dehydrogenase (quinone) activity
GPY59_RS02285	COG0366	Alpha amylase catalytic
GPY59_RS02290	COG0789	Transcriptional regulator
GPY59_RS02295	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GPY59_RS02305	COG4934	collagen metabolic process
GPY59_RS02315	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GPY59_RS02320	COG0583	DNA-binding transcription factor activity
GPY59_RS02340	COG2610	gluconate transmembrane transporter activity
GPY59_RS02345	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GPY59_RS02350	COG3622	Belongs to the hyi family
GPY59_RS02355	COG0235	Class ii aldolase
GPY59_RS02360	COG3395	kinase activity
GPY59_RS02365	COG2084	Dehydrogenase
GPY59_RS02370	COG1349	DNA-binding transcription factor activity
GPY59_RS02380	COG0747	negative chemotaxis
GPY59_RS02385	COG4608	Belongs to the ABC transporter superfamily
GPY59_RS02390	COG0444	Belongs to the ABC transporter superfamily
GPY59_RS02395	COG0534	Mate efflux family protein
GPY59_RS02400	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPY59_RS02405	COG0784	Response regulator, receiver
GPY59_RS02405	COG0835	chemotaxis
GPY59_RS02415	COG0748	coenzyme F420 binding
GPY59_RS02420	COG3721	Heme iron utilization protein
GPY59_RS02430	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GPY59_RS02435	COG0811	peptide transport
GPY59_RS02440	COG0848	biopolymer transport protein
GPY59_RS02450	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY59_RS02455	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GPY59_RS02495	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GPY59_RS02505	COG0633	Ferredoxin
GPY59_RS02505	COG3217	Mosc domain protein beta barrel domain protein
GPY59_RS02505	COG0633	Ferredoxin
GPY59_RS02505	COG3217	Mosc domain protein beta barrel domain protein
GPY59_RS02510	COG0401	homolog of Blt101
GPY59_RS02520	COG0418	dihydroorotase activity
GPY59_RS02525	COG2354	Protein conserved in bacteria
GPY59_RS02555	COG3833	ABC-type maltose transport systems, permease component
GPY59_RS02560	COG1175	transmembrane transport
GPY59_RS02570	COG3842	ATPase activity
GPY59_RS02575	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GPY59_RS02590	COG0489	protein tyrosine kinase activity
GPY59_RS02590	COG3206	protein involved in exopolysaccharide biosynthesis
GPY59_RS02635	COG1309	transcriptional regulator
GPY59_RS02640	COG2130	NADP-dependent
GPY59_RS02650	COG0753	catalase activity
GPY59_RS02655	COG2084	Dehydrogenase
GPY59_RS02685	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY59_RS02690	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
GPY59_RS02700	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPY59_RS02705	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GPY59_RS02725	COG0583	DNA-binding transcription factor activity
GPY59_RS02730	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY59_RS02735	COG0569	domain protein
GPY59_RS02740	COG0745	RESPONSE REGULATOR receiver
GPY59_RS02745	COG5002	protein histidine kinase activity
GPY59_RS02750	COG1132	(ABC) transporter
GPY59_RS02755	COG4774	siderophore transport
GPY59_RS02760	COG1120	ATPase activity
GPY59_RS02765	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GPY59_RS02800	COG2197	response regulator
GPY59_RS02815	COG0714	Associated with various cellular activities
GPY59_RS02835	COG2304	oxidoreductase activity
GPY59_RS02850	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GPY59_RS02855	COG0581	inorganic phosphate transmembrane transporter activity
GPY59_RS02860	COG0573	inorganic phosphate transmembrane transporter activity
GPY59_RS02865	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GPY59_RS02890	COG4771	TonB-dependent receptor
GPY59_RS02895	COG1770	oligopeptidase
GPY59_RS02900	COG0513	Belongs to the DEAD box helicase family
GPY59_RS02910	COG1388	LysM domain
GPY59_RS02910	COG1376	ErfK ybiS ycfS ynhG family protein
GPY59_RS02915	COG0415	Belongs to the DNA photolyase family
GPY59_RS02920	COG0789	Transcriptional regulator
GPY59_RS02925	COG3272	Protein of unknown function (DUF1722)
GPY59_RS02935	COG0813	purine-nucleoside phosphorylase activity
GPY59_RS02950	COG3706	GGDEF domain
GPY59_RS02960	COG1566	PFAM secretion protein HlyD family protein
GPY59_RS02965	COG4720	Psort location CytoplasmicMembrane, score
GPY59_RS02970	COG1122	ATPase activity
GPY59_RS02990	COG0348	domain, Protein
GPY59_RS02995	COG0437	4 iron, 4 sulfur cluster binding
GPY59_RS03000	COG1247	-acetyltransferase
GPY59_RS03020	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPY59_RS03030	COG1067	ATP-dependent peptidase activity
GPY59_RS03040	COG4172	Belongs to the ABC transporter superfamily
GPY59_RS03045	COG1505	serine-type exopeptidase activity
GPY59_RS03050	COG0583	DNA-binding transcription factor activity
GPY59_RS03055	COG1620	l-lactate permease
GPY59_RS03060	COG1304	FMN binding
GPY59_RS03070	COG0668	transmembrane transport
GPY59_RS03105	COG1063	alcohol dehydrogenase
GPY59_RS03110	COG0156	8-amino-7-oxononanoate synthase activity
GPY59_RS03115	COG3300	MHYT domain
GPY59_RS03115	COG5001	Diguanylate cyclase
GPY59_RS03140	COG0745	RESPONSE REGULATOR receiver
GPY59_RS03165	COG0346	lactoylglutathione lyase activity
GPY59_RS03225	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GPY59_RS03240	COG2204	response regulator
GPY59_RS03265	COG1987	bacterial-type flagellum assembly
GPY59_RS03275	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GPY59_RS03290	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY59_RS03300	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GPY59_RS03305	COG1516	flagellar protein fliS
GPY59_RS03320	COG1580	Controls the rotational direction of flagella during chemotaxis
GPY59_RS03325	COG1191	sigma factor activity
GPY59_RS03330	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GPY59_RS03335	COG1360	Flagellar Motor Protein
GPY59_RS03375	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GPY59_RS03380	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GPY59_RS03395	COG2205	protein histidine kinase activity
GPY59_RS03400	COG0745	RESPONSE REGULATOR receiver
GPY59_RS03420	COG2814	Major facilitator Superfamily
GPY59_RS03465	COG0628	permease
GPY59_RS03470	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GPY59_RS03490	COG4628	conserved protein (DUF2132)
GPY59_RS03495	COG0583	DNA-binding transcription factor activity
GPY59_RS03520	COG1686	Belongs to the peptidase S11 family
GPY59_RS03540	COG0415	Belongs to the DNA photolyase family
GPY59_RS03545	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
GPY59_RS03550	COG3397	chitin binding
GPY59_RS03555	COG4667	esterase of the alpha-beta hydrolase superfamily
GPY59_RS03560	COG2095	MarC family integral membrane protein
GPY59_RS03595	COG0583	DNA-binding transcription factor activity
GPY59_RS03605	COG1301	dicarboxylic acid transport
GPY59_RS03620	COG3339	Conserved Protein
GPY59_RS03625	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPY59_RS03630	COG0700	Nucleoside recognition
GPY59_RS03635	COG3366	ferrous iron transmembrane transporter activity
GPY59_RS03650	COG0366	Alpha amylase catalytic
GPY59_RS03655	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GPY59_RS03660	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GPY59_RS03665	COG1640	4-alpha-glucanotransferase
GPY59_RS03670	COG0058	SHG alpha-glucan phosphorylase activity
GPY59_RS03675	COG2909	trisaccharide binding
GPY59_RS03690	COG1999	signal sequence binding
GPY59_RS03695	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY59_RS03695	COG1263	PTS System
GPY59_RS03700	COG1162	GTPase activity
GPY59_RS03705	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GPY59_RS03710	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
GPY59_RS03730	COG2356	endonuclease I
GPY59_RS03750	COG4580	involved in the transport of maltose and maltodextrins
GPY59_RS03760	COG1760	l-serine dehydratase
GPY59_RS03810	COG1609	Transcriptional regulator
GPY59_RS03815	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GPY59_RS03840	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPY59_RS03845	COG1609	Transcriptional regulator
GPY59_RS03855	COG2814	Major facilitator Superfamily
GPY59_RS03870	COG0739	heme binding
GPY59_RS03880	COG0612	Peptidase, M16
GPY59_RS03885	COG0840	transmembrane signaling receptor activity
GPY59_RS03890	COG1120	ATPase activity
GPY59_RS03895	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY59_RS03900	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY59_RS03905	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GPY59_RS03910	COG4772	TonB-dependent receptor
GPY59_RS03930	COG2814	Major facilitator Superfamily
GPY59_RS03935	COG4264	IucA IucC family
GPY59_RS03940	COG0019	diaminopimelate decarboxylase activity
GPY59_RS03945	COG1653	transport
GPY59_RS03955	COG0745	RESPONSE REGULATOR receiver
GPY59_RS03985	COG1136	(ABC) transporter
GPY59_RS04035	COG1764	response to oxidative stress
GPY59_RS04040	COG1846	Transcriptional regulator
GPY59_RS04045	COG0450	alkyl hydroperoxide reductase
GPY59_RS04050	COG3634	alkyl hydroperoxide reductase activity
GPY59_RS04100	COG2258	MOSC domain
GPY59_RS04105	COG0513	Belongs to the DEAD box helicase family
GPY59_RS04115	COG1132	(ABC) transporter
GPY59_RS04155	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPY59_RS04180	COG0259	pyridoxamine-phosphate oxidase activity
GPY59_RS04230	COG4166	transmembrane transport
GPY59_RS04250	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GPY59_RS04255	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY59_RS04255	COG1263	PTS System
GPY59_RS04260	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPY59_RS04265	COG3340	Belongs to the peptidase S51 family
GPY59_RS04285	COG1444	tRNA N-acetyltransferase activity
GPY59_RS04310	COG4608	Belongs to the ABC transporter superfamily
GPY59_RS04315	COG0444	Belongs to the ABC transporter superfamily
GPY59_RS04325	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GPY59_RS04325	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
GPY59_RS04350	COG0772	Belongs to the SEDS family
GPY59_RS04360	COG1136	(ABC) transporter
GPY59_RS04380	COG3275	phosphorelay sensor kinase activity
GPY59_RS04385	COG3279	Response regulator of the LytR AlgR family
GPY59_RS04395	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GPY59_RS04415	COG0786	glutamate:sodium symporter activity
GPY59_RS04425	COG1131	(ABC) transporter
GPY59_RS04430	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY59_RS04435	COG0786	glutamate:sodium symporter activity
GPY59_RS04445	COG0363	glucosamine-6-phosphate deaminase activity
GPY59_RS04465	COG1741	Belongs to the pirin family
GPY59_RS04470	COG2259	Doxx family
GPY59_RS04480	COG2169	Transcriptional regulator
GPY59_RS04480	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GPY59_RS04485	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GPY59_RS04495	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GPY59_RS04520	COG0596	Alpha beta hydrolase
GPY59_RS04535	COG3123	guanosine phosphorylase activity
GPY59_RS04545	COG5001	Diguanylate cyclase
GPY59_RS04550	COG0534	Mate efflux family protein
GPY59_RS04555	COG0564	pseudouridine synthase activity
GPY59_RS04570	COG0583	DNA-binding transcription factor activity
GPY59_RS04575	COG0561	phosphatase activity
GPY59_RS04585	COG2199	diguanylate cyclase activity
GPY59_RS04600	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
GPY59_RS04605	COG2162	N-hydroxyarylamine O-acetyltransferase activity
GPY59_RS04610	COG0583	DNA-binding transcription factor activity
GPY59_RS04615	COG2375	cellular response to nickel ion
GPY59_RS04645	COG1357	PFAM Pentapeptide repeats (8 copies)
GPY59_RS04650	COG3047	cAMP biosynthetic process
GPY59_RS04710	COG3835	regulator
GPY59_RS04715	COG2610	gluconate transmembrane transporter activity
GPY59_RS04720	COG1929	Belongs to the glycerate kinase type-1 family
GPY59_RS04725	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY59_RS04745	COG0456	acetyltransferase
GPY59_RS04760	COG1028	Short-chain dehydrogenase reductase Sdr
GPY59_RS04765	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY59_RS04770	COG3005	denitrification pathway
GPY59_RS04785	COG0352	thiamine-phosphate diphosphorylase activity
GPY59_RS04795	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GPY59_RS04800	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GPY59_RS04805	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GPY59_RS04810	COG1116	anion transmembrane transporter activity
GPY59_RS04815	COG0351	phosphomethylpyrimidine kinase
GPY59_RS04820	COG0312	modulator of DNA gyrase
GPY59_RS04825	COG0312	modulator of DNA gyrase
GPY59_RS04830	COG1901	pseudouridine methyltransferase
GPY59_RS04890	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GPY59_RS04900	COG0584	glycerophosphoryl diester phosphodiesterase
GPY59_RS04905	COG0745	RESPONSE REGULATOR receiver
GPY59_RS04925	COG0811	peptide transport
GPY59_RS04930	COG0811	peptide transport
GPY59_RS04935	COG0848	biopolymer transport protein
GPY59_RS04980	COG0803	Belongs to the bacterial solute-binding protein 9 family
GPY59_RS04985	COG1121	(ABC) transporter
GPY59_RS04990	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GPY59_RS05005	COG1770	oligopeptidase
GPY59_RS05010	COG2814	Major facilitator Superfamily
GPY59_RS05015	COG0010	Belongs to the arginase family
GPY59_RS05020	COG1166	arginine decarboxylase activity
GPY59_RS05030	COG4067	protein conserved in archaea
GPY59_RS05030	COG0189	ligase activity
GPY59_RS05035	COG0189	ligase activity
GPY59_RS05055	COG0583	DNA-binding transcription factor activity
GPY59_RS05085	COG3706	GGDEF domain
GPY59_RS05110	COG0579	oxidoreductase
GPY59_RS05120	COG1294	oxidase, subunit
GPY59_RS05125	COG1271	oxidase subunit
GPY59_RS05135	COG3033	Beta-eliminating lyase
GPY59_RS05150	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPY59_RS05165	COG3706	GGDEF domain
GPY59_RS05180	COG3706	GGDEF domain
GPY59_RS05185	COG0415	Belongs to the DNA photolyase family
GPY59_RS05190	COG3046	protein related to deoxyribodipyrimidine photolyase
GPY59_RS05205	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY59_RS05205	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY59_RS05210	COG1765	OsmC-like protein
GPY59_RS05215	COG0110	maltose O-acetyltransferase activity
GPY59_RS05250	COG1011	Hydrolase
GPY59_RS05265	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
GPY59_RS05270	COG3338	carbonate dehydratase activity
GPY59_RS05275	COG2067	long-chain fatty acid transport protein
GPY59_RS05280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY59_RS05285	COG0577	efflux transmembrane transporter activity
GPY59_RS05285	COG1136	(ABC) transporter
GPY59_RS05300	COG1309	transcriptional regulator
GPY59_RS05305	COG3240	lipase activity
GPY59_RS05335	COG1609	Transcriptional regulator
GPY59_RS05355	COG1840	ABC-type Fe3 transport system, periplasmic component
GPY59_RS05360	COG3842	ATPase activity
GPY59_RS05385	COG2990	Protein conserved in bacteria
GPY59_RS05410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPY59_RS05415	COG2866	Carboxypeptidase
GPY59_RS05425	COG0583	DNA-binding transcription factor activity
GPY59_RS05440	COG1760	l-serine dehydratase
GPY59_RS05460	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GPY59_RS05465	COG0741	lytic transglycosylase activity
GPY59_RS05485	COG1815	bacterial-type flagellum-dependent cell motility
GPY59_RS05490	COG1558	bacterial-type flagellum-dependent cell motility
GPY59_RS05495	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GPY59_RS05500	COG1749	Flagellar hook protein flgE
GPY59_RS05505	COG4787	bacterial-type flagellum-dependent cell motility
GPY59_RS05510	COG4786	Flagellar basal body rod
GPY59_RS05515	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GPY59_RS05520	COG1706	bacterial-type flagellum-dependent cell motility
GPY59_RS05530	COG1256	bacterial-type flagellum assembly
GPY59_RS05530	COG4786	Flagellar basal body rod
GPY59_RS05555	COG1304	FMN binding
GPY59_RS05570	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY59_RS05580	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GPY59_RS05585	COG0459	protein refolding
GPY59_RS05595	COG1280	lysine exporter protein (LysE YggA)
GPY59_RS05615	COG1309	transcriptional regulator
GPY59_RS05625	COG4303	Ethanolamine ammonia lyase large subunit
GPY59_RS05630	COG4302	ethanolamine ammonia-lyase activity
GPY59_RS05635	COG0531	amino acid
GPY59_RS05640	COG2070	2-Nitropropane dioxygenase
GPY59_RS05650	COG1349	DNA-binding transcription factor activity
GPY59_RS05665	COG1335	isochorismatase
GPY59_RS05675	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GPY59_RS05700	COG0583	DNA-binding transcription factor activity
GPY59_RS05715	COG3713	MltA-interacting MipA family protein
GPY59_RS05720	COG3015	lipoprotein NlpE involved in copper resistance
GPY59_RS05725	COG3448	diguanylate cyclase activity
GPY59_RS05725	COG4175	Glycine betaine
GPY59_RS05730	COG4176	ABC-type proline glycine betaine transport system permease component
GPY59_RS05735	COG1342	Belongs to the UPF0251 family
GPY59_RS05760	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPY59_RS05770	COG4948	Mandelate Racemase Muconate Lactonizing
GPY59_RS05780	COG0583	DNA-binding transcription factor activity
GPY59_RS05815	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GPY59_RS05820	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GPY59_RS05865	COG3842	ATPase activity
GPY59_RS05895	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPY59_RS05915	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY59_RS05920	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GPY59_RS05925	COG2197	response regulator
GPY59_RS05940	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GPY59_RS05945	COG0252	asparaginase activity
GPY59_RS05955	COG0583	DNA-binding transcription factor activity
GPY59_RS05970	COG3122	Protein conserved in bacteria
GPY59_RS05975	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GPY59_RS05980	COG1012	belongs to the aldehyde dehydrogenase family
GPY59_RS05985	COG1522	sequence-specific DNA binding
GPY59_RS05990	COG3608	succinylglutamate desuccinylase aspartoacylase
GPY59_RS05995	COG0006	proline dipeptidase activity
GPY59_RS06000	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY59_RS06010	COG1028	Short-chain dehydrogenase reductase Sdr
GPY59_RS06020	COG1063	alcohol dehydrogenase
GPY59_RS06025	COG1902	pentaerythritol trinitrate reductase activity
GPY59_RS06040	COG0583	DNA-binding transcription factor activity
GPY59_RS06050	COG0513	Belongs to the DEAD box helicase family
GPY59_RS06080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY59_RS06085	COG2207	Transcriptional regulator
GPY59_RS06085	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GPY59_RS06090	COG0583	DNA-binding transcription factor activity
GPY59_RS06095	COG0300	oxidoreductase activity
GPY59_RS06110	COG3746	phosphate-selective porin O and P
GPY59_RS06125	COG1028	Short-chain dehydrogenase reductase Sdr
GPY59_RS06130	COG1404	Belongs to the peptidase S8 family
GPY59_RS06140	COG0583	DNA-binding transcription factor activity
GPY59_RS06145	COG4771	TonB-dependent receptor
GPY59_RS06165	COG1263	PTS System
GPY59_RS06165	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY59_RS06170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY59_RS06175	COG1621	beta-fructofuranosidase activity
GPY59_RS06185	COG0625	glutathione transferase activity
GPY59_RS06190	COG1686	Belongs to the peptidase S11 family
GPY59_RS06200	COG0678	peroxiredoxin activity
GPY59_RS06200	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPY59_RS06205	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GPY59_RS06220	COG1278	Cold shock
GPY59_RS06225	COG1741	Belongs to the pirin family
GPY59_RS06230	COG4667	esterase of the alpha-beta hydrolase superfamily
GPY59_RS06250	COG2194	sulfuric ester hydrolase activity
GPY59_RS06255	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GPY59_RS06265	COG2205	protein histidine kinase activity
GPY59_RS06270	COG0745	RESPONSE REGULATOR receiver
GPY59_RS06285	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPY59_RS06305	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GPY59_RS06315	COG2814	Major facilitator Superfamily
GPY59_RS06330	COG1418	mRNA catabolic process
GPY59_RS06335	COG0402	S-adenosylhomocysteine deaminase activity
GPY59_RS06340	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GPY59_RS06345	COG2239	Acts as a magnesium transporter
GPY59_RS06350	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GPY59_RS06355	COG1566	PFAM secretion protein HlyD family protein
GPY59_RS06380	COG0745	RESPONSE REGULATOR receiver
GPY59_RS06385	COG2205	protein histidine kinase activity
GPY59_RS06400	COG0531	amino acid
GPY59_RS06415	COG0583	DNA-binding transcription factor activity
GPY59_RS06440	COG0784	Response regulator, receiver
GPY59_RS06440	COG5002	protein histidine kinase activity
GPY59_RS06440	COG2205	protein histidine kinase activity
GPY59_RS06460	COG3132	Protein of unknown function, DUF480
GPY59_RS06465	COG2827	Endonuclease containing a URI domain
GPY59_RS06470	COG1879	ABC-type sugar transport system periplasmic component
GPY59_RS06475	COG2205	protein histidine kinase activity
GPY59_RS06475	COG0784	Response regulator, receiver
GPY59_RS06530	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY59_RS06535	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY59_RS06545	COG1280	lysine exporter protein (LysE YggA)
GPY59_RS06555	COG0183	Belongs to the thiolase family
GPY59_RS06565	COG3243	poly(R)-hydroxyalkanoic acid synthase
GPY59_RS06575	COG3005	denitrification pathway
GPY59_RS06585	COG0243	molybdopterin cofactor binding
GPY59_RS06595	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GPY59_RS06600	COG3850	Histidine kinase
GPY59_RS06605	COG2197	response regulator
GPY59_RS06620	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPY59_RS06640	COG0840	transmembrane signaling receptor activity
GPY59_RS06650	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY59_RS06660	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY59_RS06665	COG2814	Major facilitator Superfamily
GPY59_RS06670	COG0840	transmembrane signaling receptor activity
GPY59_RS06675	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GPY59_RS06680	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GPY59_RS06695	COG2897	thiosulfate sulfurtransferase activity
GPY59_RS06730	COG0038	chloride channel
GPY59_RS06745	COG4989	oxidoreductase activity
GPY59_RS06760	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GPY59_RS06760	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GPY59_RS06770	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
GPY59_RS06815	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY59_RS06830	COG0739	heme binding
GPY59_RS06870	COG3501	Rhs element vgr protein
GPY59_RS06895	COG0515	serine threonine protein kinase
GPY59_RS06930	COG1522	sequence-specific DNA binding
GPY59_RS07055	COG2814	Major facilitator Superfamily
GPY59_RS07065	COG0583	DNA-binding transcription factor activity
GPY59_RS07070	COG4221	oxidoreductase activity
GPY59_RS07075	COG0589	response to stress
GPY59_RS07085	COG2111	Na H antiporter
GPY59_RS07085	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GPY59_RS07105	COG2212	antiporter activity
GPY59_RS07110	COG1320	monovalent cation:proton antiporter activity
GPY59_RS07115	COG2188	Transcriptional regulator
GPY59_RS07120	COG1486	melibiose metabolic process
GPY59_RS07125	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY59_RS07125	COG1263	PTS System
GPY59_RS07130	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPY59_RS07160	COG1022	Amp-dependent synthetase and ligase
GPY59_RS07190	COG0500	methyltransferase
GPY59_RS07195	COG1028	Short-chain dehydrogenase reductase Sdr
GPY59_RS07205	COG3527	Alpha-acetolactate decarboxylase
GPY59_RS07215	COG0384	phenazine biosynthesis protein PhzF
GPY59_RS07225	COG1294	oxidase, subunit
GPY59_RS07230	COG1271	oxidase subunit
GPY59_RS07235	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY59_RS07240	COG0110	maltose O-acetyltransferase activity
GPY59_RS07250	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GPY59_RS07250	COG3264	Mechanosensitive ion channel
GPY59_RS07275	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GPY59_RS07280	COG1960	acyl-CoA dehydrogenase activity
GPY59_RS07290	COG0183	Belongs to the thiolase family
GPY59_RS07300	COG1960	acyl-CoA dehydrogenase activity
GPY59_RS07305	COG1024	Enoyl-CoA hydratase
GPY59_RS07320	COG1028	Short-chain dehydrogenase reductase Sdr
GPY59_RS07325	COG0745	RESPONSE REGULATOR receiver
GPY59_RS07325	COG3706	GGDEF domain
GPY59_RS07330	COG1309	transcriptional regulator
GPY59_RS07335	COG1012	belongs to the aldehyde dehydrogenase family
GPY59_RS07350	COG4176	ABC-type proline glycine betaine transport system permease component
GPY59_RS07355	COG4175	Glycine betaine
GPY59_RS07355	COG0517	IMP dehydrogenase activity
GPY59_RS07370	COG0330	HflC and HflK could
GPY59_RS07385	COG0784	Response regulator, receiver
GPY59_RS07385	COG2205	protein histidine kinase activity
GPY59_RS07395	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GPY59_RS07455	COG5001	Diguanylate cyclase
GPY59_RS07460	COG1869	D-ribose catabolic process
GPY59_RS07465	COG1129	ABC transporter
GPY59_RS07470	COG1172	Belongs to the binding-protein-dependent transport system permease family
GPY59_RS07475	COG1879	ABC-type sugar transport system periplasmic component
GPY59_RS07480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY59_RS07485	COG1609	Transcriptional regulator
GPY59_RS07500	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
GPY59_RS07510	COG4607	ABC-type enterochelin transport system periplasmic component
GPY59_RS07515	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY59_RS07520	COG4605	iron ion homeostasis
GPY59_RS07525	COG4604	ABC transporter, ATP-binding protein
GPY59_RS07530	COG0789	Transcriptional regulator
GPY59_RS07535	COG2207	Transcriptional regulator
GPY59_RS07540	COG1629	transport
GPY59_RS07540	COG4771	TonB-dependent receptor
GPY59_RS07570	COG1289	transmembrane transporter activity
GPY59_RS07575	COG0210	DNA helicase
GPY59_RS07580	COG1803	Methylglyoxal synthase
GPY59_RS07585	COG1879	ABC-type sugar transport system periplasmic component
GPY59_RS07590	COG0784	Response regulator, receiver
GPY59_RS07590	COG2198	Histidine kinase
GPY59_RS07590	COG2205	protein histidine kinase activity
GPY59_RS07605	COG0745	RESPONSE REGULATOR receiver
GPY59_RS07610	COG3119	arylsulfatase activity
GPY59_RS07620	COG3119	arylsulfatase activity
GPY59_RS07625	COG0641	radical SAM
GPY59_RS07630	COG0714	Associated with various cellular activities
GPY59_RS07660	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPY59_RS07665	COG0583	DNA-binding transcription factor activity
GPY59_RS07670	COG1597	lipid kinase activity
GPY59_RS07675	COG3111	PFAM Bacterial OB fold (BOF) protein
GPY59_RS07700	COG3069	C4-dicarboxylate transmembrane transporter activity
GPY59_RS07710	COG0456	acetyltransferase
GPY59_RS07710	COG1214	PFAM Peptidase M22, glycoprotease
GPY59_RS07730	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GPY59_RS07735	COG2205	protein histidine kinase activity
GPY59_RS07735	COG0784	Response regulator, receiver
GPY59_RS07740	COG3300	MHYT domain
GPY59_RS07740	COG5001	Diguanylate cyclase
GPY59_RS07745	COG2197	response regulator
GPY59_RS07750	COG3706	GGDEF domain
GPY59_RS07760	COG2197	response regulator
GPY59_RS07770	COG0835	chemotaxis
GPY59_RS07770	COG0784	Response regulator, receiver
GPY59_RS07785	COG2962	Rard protein
GPY59_RS07805	COG2076	Multidrug Resistance protein
GPY59_RS07835	COG0069	glutamate synthase activity
GPY59_RS07835	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GPY59_RS07840	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GPY59_RS07865	COG1902	pentaerythritol trinitrate reductase activity
GPY59_RS07870	COG0346	lactoylglutathione lyase activity
GPY59_RS07890	COG2239	Acts as a magnesium transporter
GPY59_RS07920	COG0242	peptide deformylase activity
GPY59_RS07960	COG2176	DNA-directed DNA polymerase activity
GPY59_RS08015	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GPY59_RS08020	COG0697	spore germination
GPY59_RS08025	COG0583	DNA-binding transcription factor activity
GPY59_RS08030	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPY59_RS08040	COG0346	lactoylglutathione lyase activity
GPY59_RS08050	COG0509	glycine decarboxylation via glycine cleavage system
GPY59_RS08055	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GPY59_RS08065	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GPY59_RS08095	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY59_RS08095	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY59_RS08095	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
GPY59_RS08100	COG1105	Belongs to the carbohydrate kinase PfkB family
GPY59_RS08105	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY59_RS08105	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY59_RS08110	COG1609	Transcriptional regulator
GPY59_RS08125	COG2199	diguanylate cyclase activity
GPY59_RS08125	COG2200	EAL domain
GPY59_RS08125	COG2203	Gaf domain
GPY59_RS08130	COG0765	amino acid transport
GPY59_RS08135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY59_RS08140	COG0765	amino acid transport
GPY59_RS08145	COG1126	abc transporter atp-binding protein
GPY59_RS08155	COG1979	alcohol dehydrogenase
GPY59_RS08160	COG2207	Transcriptional regulator
GPY59_RS08175	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GPY59_RS08180	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GPY59_RS08200	COG4206	TonB-dependent receptor
GPY59_RS08220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY59_RS08225	COG0534	Mate efflux family protein
GPY59_RS08230	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
GPY59_RS08235	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GPY59_RS08240	COG2937	Belongs to the GPAT DAPAT family
GPY59_RS08245	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GPY59_RS08250	COG3161	chorismate lyase activity
GPY59_RS08255	COG1580	Controls the rotational direction of flagella during chemotaxis
GPY59_RS08260	COG0705	Rhomboid family
GPY59_RS08265	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY59_RS08275	COG2177	Part of the ABC transporter FtsEX involved in
GPY59_RS08280	COG2884	Cell division ATP-binding protein ftsE
GPY59_RS08285	COG0552	protein localization to endoplasmic reticulum
GPY59_RS08290	COG0742	ribosomal rna small subunit methyltransferase
GPY59_RS08300	COG2095	MarC family integral membrane protein
GPY59_RS08340	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPY59_RS08345	COG0640	Transcriptional regulator
GPY59_RS08350	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GPY59_RS08355	COG1280	lysine exporter protein (LysE YggA)
GPY59_RS08360	COG2267	carboxylic ester hydrolase activity
GPY59_RS08365	COG0561	phosphatase activity
GPY59_RS08385	COG2200	EAL domain
GPY59_RS08385	COG3287	FIST C domain
GPY59_RS08385	COG2199	diguanylate cyclase activity
GPY59_RS08390	COG1011	Hydrolase
GPY59_RS08395	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GPY59_RS08410	COG0019	diaminopimelate decarboxylase activity
GPY59_RS08420	COG1965	Belongs to the frataxin family
GPY59_RS08425	COG3072	Adenylate cyclase
GPY59_RS08430	COG0181	hydroxymethylbilane synthase activity
GPY59_RS08435	COG1587	Uroporphyrinogen-III synthase
GPY59_RS08440	COG2959	enzyme of heme biosynthesis
GPY59_RS08445	COG3071	HemY protein
GPY59_RS08490	COG0633	Ferredoxin
GPY59_RS08495	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GPY59_RS08505	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GPY59_RS08510	COG3118	belongs to the thioredoxin family
GPY59_RS08515	COG0513	Belongs to the DEAD box helicase family
GPY59_RS08520	COG0248	Ppx GppA phosphatase
GPY59_RS08530	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GPY59_RS08540	COG0514	ATP-dependent DNA helicase (RecQ)
GPY59_RS08545	COG2962	Rard protein
GPY59_RS08555	COG1280	lysine exporter protein (LysE YggA)
GPY59_RS08560	COG0405	Gamma-glutamyltransferase
GPY59_RS08570	COG0210	DNA helicase
GPY59_RS08580	COG3220	belongs to the UPF0276 family
GPY59_RS08610	COG0006	proline dipeptidase activity
GPY59_RS08610	COG0006	proline dipeptidase activity
GPY59_RS08625	COG2104	thiamine diphosphate biosynthetic process
GPY59_RS08630	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GPY59_RS08650	COG2132	Multicopper oxidase
GPY59_RS08695	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GPY59_RS08710	COG0408	coproporphyrinogen oxidase activity
GPY59_RS08715	COG0009	L-threonylcarbamoyladenylate synthase
GPY59_RS08720	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GPY59_RS08725	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GPY59_RS08730	COG0551	DNA topoisomerase type I activity
GPY59_RS08735	COG2922	Belongs to the Smg family
GPY59_RS08740	COG0758	DNA mediated transformation
GPY59_RS08750	COG0242	peptide deformylase activity
GPY59_RS08760	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GPY59_RS08760	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GPY59_RS08765	COG0569	domain protein
GPY59_RS08770	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY59_RS08780	COG1272	protein, Hemolysin III
GPY59_RS08785	COG4326	sporulation control protein
GPY59_RS08795	COG3084	Protein conserved in bacteria
GPY59_RS08805	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GPY59_RS08810	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPY59_RS08815	COG0204	Acyl-transferase
GPY59_RS08825	COG0606	chelatase, subunit chli
GPY59_RS08835	COG3978	acetolactate synthase activity
GPY59_RS08840	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GPY59_RS08845	COG0129	dihydroxy-acid dehydratase activity
GPY59_RS08855	COG0583	DNA-binding transcription factor activity
GPY59_RS08860	COG2814	Major facilitator Superfamily
GPY59_RS08870	COG0765	amino acid transport
GPY59_RS08880	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GPY59_RS08885	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GPY59_RS08890	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GPY59_RS08895	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GPY59_RS08900	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GPY59_RS08905	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GPY59_RS08915	COG0356	it plays a direct role in the translocation of protons across the membrane
GPY59_RS08920	COG3312	ion transport
GPY59_RS08925	COG1475	DNA binding
GPY59_RS08930	COG1192	Involved in chromosome partitioning
GPY59_RS08935	COG0357	Ribosomal RNA small subunit methyltransferase G
GPY59_RS08940	COG0445	tRNA wobble uridine modification
GPY59_RS08945	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GPY59_RS08955	COG0706	membrane insertase activity
GPY59_RS08960	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GPY59_RS08965	COG0594	ribonuclease P activity
GPY59_RS08975	COG1126	abc transporter atp-binding protein
GPY59_RS08995	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GPY59_RS09000	COG0592	DNA-directed DNA polymerase activity
GPY59_RS09010	COG0187	DNA topoisomerase II activity
GPY59_RS09025	COG0071	Belongs to the small heat shock protein (HSP20) family
GPY59_RS09030	COG3977	Valine--pyruvate aminotransferase
GPY59_RS09035	COG0366	Alpha amylase catalytic
GPY59_RS09050	COG2119	membrane
GPY59_RS09060	COG0425	Belongs to the sulfur carrier protein TusA family
GPY59_RS09075	COG0604	alcohol dehydrogenase
GPY59_RS09080	COG0183	Belongs to the thiolase family
GPY59_RS09090	COG1739	Uncharacterized protein family UPF0029
GPY59_RS09095	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY59_RS09135	COG0583	DNA-binding transcription factor activity
GPY59_RS09140	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GPY59_RS09145	COG2960	long-chain fatty acid transporting porin activity
GPY59_RS09150	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY59_RS09155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY59_RS09210	COG4172	Belongs to the ABC transporter superfamily
GPY59_RS09215	COG4166	transmembrane transport
GPY59_RS09225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY59_RS09240	COG1609	Transcriptional regulator
GPY59_RS09245	COG0583	DNA-binding transcription factor activity
GPY59_RS09255	COG2076	Multidrug Resistance protein
GPY59_RS09260	COG0129	dihydroxy-acid dehydratase activity
GPY59_RS09265	COG3265	gluconokinase activity
GPY59_RS09270	COG2610	gluconate transmembrane transporter activity
GPY59_RS09275	COG0800	Aldolase
GPY59_RS09280	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GPY59_RS09285	COG0583	DNA-binding transcription factor activity
GPY59_RS09290	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY59_RS09295	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GPY59_RS09305	COG1522	sequence-specific DNA binding
GPY59_RS09310	COG5001	Diguanylate cyclase
GPY59_RS09310	COG5002	protein histidine kinase activity
GPY59_RS09315	COG0742	ribosomal rna small subunit methyltransferase
GPY59_RS09325	COG0697	spore germination
GPY59_RS09330	COG0589	response to stress
GPY59_RS09335	COG1528	Iron-storage protein
GPY59_RS09345	COG2081	HI0933 family
GPY59_RS09375	COG1597	lipid kinase activity
GPY59_RS09405	COG0628	permease
GPY59_RS09420	COG1322	Protein conserved in bacteria
GPY59_RS09425	COG2226	methyltransferase
GPY59_RS09430	COG3165	ubiquinone biosynthetic process from chorismate
GPY59_RS09435	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GPY59_RS09450	COG0805	protein transport
GPY59_RS09460	COG0084	hydrolase, TatD family'
GPY59_RS09475	COG0456	acetyltransferase
GPY59_RS09485	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPY59_RS09485	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPY59_RS09490	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GPY59_RS09520	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GPY59_RS09525	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GPY59_RS09535	COG2204	response regulator
GPY59_RS09540	COG3852	Histidine kinase
GPY59_RS09550	COG0174	glutamine synthetase
GPY59_RS09560	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GPY59_RS09570	COG1295	ribonuclease BN
GPY59_RS09575	COG1490	D-aminoacyl-tRNA deacylase activity
GPY59_RS09580	COG0456	acetyltransferase
GPY59_RS09590	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GPY59_RS09595	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GPY59_RS09600	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GPY59_RS09605	COG3031	protein transport across the cell outer membrane
GPY59_RS09615	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY59_RS09620	COG1459	type II secretion system
GPY59_RS09625	COG2165	general secretion pathway protein
GPY59_RS09630	COG2165	general secretion pathway protein
GPY59_RS09635	COG2165	general secretion pathway protein
GPY59_RS09640	COG4795	General secretion pathway protein
GPY59_RS09645	COG3156	type II secretion system protein K
GPY59_RS09650	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GPY59_RS09655	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GPY59_RS09665	COG1218	3'(2'),5'-bisphosphate nucleotidase
GPY59_RS09670	COG0494	nUDIX hydrolase
GPY59_RS09680	COG1040	competence protein
GPY59_RS09695	COG2183	response to ionizing radiation
GPY59_RS09705	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY59_RS09715	COG0745	RESPONSE REGULATOR receiver
GPY59_RS09720	COG2205	protein histidine kinase activity
GPY59_RS09725	COG2233	PERMEase
GPY59_RS09730	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GPY59_RS09735	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPY59_RS09740	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GPY59_RS09745	COG1758	RNA polymerase activity
GPY59_RS09750	COG0194	GDP metabolic process
GPY59_RS09765	COG0848	biopolymer transport protein
GPY59_RS09770	COG0811	peptide transport
GPY59_RS09795	COG4174	ABC transporter (Permease)
GPY59_RS09800	COG4239	(ABC) transporter, permease
GPY59_RS09805	COG0747	negative chemotaxis
GPY59_RS09810	COG0444	Belongs to the ABC transporter superfamily
GPY59_RS09815	COG4608	Belongs to the ABC transporter superfamily
GPY59_RS09825	COG1561	YicC-like family, N-terminal region
GPY59_RS09830	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GPY59_RS09840	COG1560	Kdo2-lipid A biosynthetic process
GPY59_RS09845	COG1309	transcriptional regulator
GPY59_RS09850	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GPY59_RS09860	COG2003	Belongs to the UPF0758 family
GPY59_RS09885	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GPY59_RS09900	COG0463	Glycosyl transferase, family 2
GPY59_RS09905	COG0859	PFAM glycosyl transferase family 9
GPY59_RS09910	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GPY59_RS09915	COG3642	lipopolysaccharide core region biosynthetic process
GPY59_RS09945	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GPY59_RS09955	COG1028	Short-chain dehydrogenase reductase Sdr
GPY59_RS09960	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GPY59_RS09985	COG1519	Transferase
GPY59_RS09990	COG0859	PFAM glycosyl transferase family 9
GPY59_RS09995	COG1560	Kdo2-lipid A biosynthetic process
GPY59_RS10005	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY59_RS10080	COG0438	transferase activity, transferring glycosyl groups
GPY59_RS10110	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GPY59_RS10125	COG0149	triose-phosphate isomerase activity
GPY59_RS10155	COG1494	fructose-1,6-bisphosphatase
GPY59_RS10165	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GPY59_RS10170	COG1575	Belongs to the MenA family. Type 1 subfamily
GPY59_RS10175	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GPY59_RS10180	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GPY59_RS10190	COG1609	Transcriptional regulator
GPY59_RS10195	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GPY59_RS10205	COG0254	rRNA binding
GPY59_RS10215	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GPY59_RS10220	COG0088	Forms part of the polypeptide exit tunnel
GPY59_RS10230	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GPY59_RS10235	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GPY59_RS10240	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GPY59_RS10245	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GPY59_RS10255	COG0255	Belongs to the universal ribosomal protein uL29 family
GPY59_RS10260	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GPY59_RS10270	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GPY59_RS10275	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GPY59_RS10285	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GPY59_RS10290	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GPY59_RS10305	COG1841	ribosomal large subunit assembly
GPY59_RS10315	COG0201	protein transport
GPY59_RS10325	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GPY59_RS10330	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GPY59_RS10340	COG0202	RNA polymerase activity
GPY59_RS10345	COG0203	ribosomal protein L17
GPY59_RS10355	COG0545	Peptidyl-prolyl cis-trans isomerase
GPY59_RS10365	COG2153	protein acetylation
GPY59_RS10370	COG0513	Belongs to the DEAD box helicase family
GPY59_RS10385	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GPY59_RS10385	COG1648	precorrin-2 dehydrogenase activity
GPY59_RS10390	COG0175	sulfate reduction
GPY59_RS10395	COG2895	sulfate adenylyltransferase (ATP) activity
GPY59_RS10400	COG3273	potassium ion transport
GPY59_RS10400	COG0471	metal ion transport
GPY59_RS10405	COG0529	Catalyzes the synthesis of activated sulfate
GPY59_RS10425	COG4181	ATPase activity
GPY59_RS10440	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
GPY59_RS10450	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY59_RS10455	COG0729	surface antigen
GPY59_RS10460	COG2911	Protein conserved in bacteria
GPY59_RS10465	COG2105	PFAM AIG2 family protein
GPY59_RS10475	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GPY59_RS10480	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GPY59_RS10490	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GPY59_RS10495	COG0163	prenyltransferase activity
GPY59_RS10500	COG4143	(ABC) transporter
GPY59_RS10505	COG1178	ABC-type Fe3 transport system permease component
GPY59_RS10510	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
GPY59_RS10515	COG0583	DNA-binding transcription factor activity
GPY59_RS10520	COG1902	pentaerythritol trinitrate reductase activity
GPY59_RS10560	COG0142	geranyltranstransferase activity
GPY59_RS10565	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GPY59_RS10575	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GPY59_RS10580	COG2966	Psort location CytoplasmicMembrane, score
GPY59_RS10590	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GPY59_RS10595	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GPY59_RS10600	COG2967	ApaG domain
GPY59_RS10605	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GPY59_RS10610	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GPY59_RS10615	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPY59_RS10620	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GPY59_RS10625	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GPY59_RS10645	COG0473	3-isopropylmalate dehydrogenase activity
GPY59_RS10650	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GPY59_RS10675	COG0583	DNA-binding transcription factor activity
GPY59_RS10680	COG1022	Amp-dependent synthetase and ligase
GPY59_RS10685	COG0028	Belongs to the TPP enzyme family
GPY59_RS10690	COG0440	acetolactate synthase activity
GPY59_RS10695	COG3706	GGDEF domain
GPY59_RS10705	COG0469	pyruvate kinase activity
GPY59_RS10710	COG1349	DNA-binding transcription factor activity
GPY59_RS10715	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GPY59_RS10725	COG2376	Dihydroxyacetone kinase
GPY59_RS10730	COG1461	Dihydroxyacetone kinase
GPY59_RS10745	COG3722	fumarate hydratase activity
GPY59_RS10755	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY59_RS10755	COG2213	PTS system mannitol-specific
GPY59_RS10780	COG0582	viral genome integration into host DNA
GPY59_RS10865	COG5018	Exonuclease
GPY59_RS10960	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPY59_RS10965	COG0358	DNA primase activity
GPY59_RS10970	COG1610	YqeY-like protein
GPY59_RS10975	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GPY59_RS10980	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GPY59_RS10985	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GPY59_RS10990	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GPY59_RS10995	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GPY59_RS11000	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GPY59_RS11005	COG1968	undecaprenyl-diphosphatase activity
GPY59_RS11015	COG3267	Type II secretory pathway component ExeA
GPY59_RS11015	COG3409	Peptidoglycan-binding domain 1 protein
GPY59_RS11025	COG0405	Gamma-glutamyltransferase
GPY59_RS11030	COG4991	sh3 domain protein
GPY59_RS11035	COG0306	phosphate transporter
GPY59_RS11040	COG1392	Phosphate transport regulator
GPY59_RS11045	COG3025	triphosphatase activity
GPY59_RS11060	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GPY59_RS11065	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GPY59_RS11065	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GPY59_RS11070	COG1538	Outer membrane efflux protein
GPY59_RS11075	COG0494	nUDIX hydrolase
GPY59_RS11080	COG3151	Protein conserved in bacteria
GPY59_RS11090	COG3150	esterase
GPY59_RS11095	COG0187	DNA topoisomerase II activity
GPY59_RS11100	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GPY59_RS11105	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GPY59_RS11115	COG3105	Protein conserved in bacteria
GPY59_RS11125	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GPY59_RS11140	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GPY59_RS11145	COG0723	plastoquinol--plastocyanin reductase activity
GPY59_RS11150	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GPY59_RS11155	COG2857	Cytochrome c1
GPY59_RS11160	COG0625	glutathione transferase activity
GPY59_RS11165	COG2969	positive regulation of protein catabolic process
GPY59_RS11170	COG2823	Periplasmic or secreted lipoprotein
GPY59_RS11175	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GPY59_RS11190	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GPY59_RS11210	COG3116	cell division
GPY59_RS11215	COG0768	penicillin binding
GPY59_RS11220	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GPY59_RS11225	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GPY59_RS11230	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GPY59_RS11235	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GPY59_RS11240	COG0772	Belongs to the SEDS family
GPY59_RS11255	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GPY59_RS11260	COG0849	cell division
GPY59_RS11265	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GPY59_RS11270	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GPY59_RS11280	COG0653	protein targeting
GPY59_RS11285	COG0494	nUDIX hydrolase
GPY59_RS11295	COG0505	Belongs to the CarA family
GPY59_RS11300	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GPY59_RS11315	COG0730	response to heat
GPY59_RS11320	COG0583	DNA-binding transcription factor activity
GPY59_RS11325	COG2860	membrane
GPY59_RS11340	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GPY59_RS11350	COG0493	'glutamate synthase
GPY59_RS11355	COG0070	glutamate synthase
GPY59_RS11355	COG0067	glutamate synthase
GPY59_RS11355	COG0069	glutamate synthase activity
GPY59_RS11365	COG0070	glutamate synthase
GPY59_RS11365	COG0069	glutamate synthase activity
GPY59_RS11365	COG0067	glutamate synthase
GPY59_RS11370	COG1242	4 iron, 4 sulfur cluster binding
GPY59_RS11375	COG2203	Gaf domain
GPY59_RS11375	COG5001	Diguanylate cyclase
GPY59_RS11375	COG4251	negative regulation of phosphorylation
GPY59_RS11375	COG3706	GGDEF domain
GPY59_RS11380	COG5002	protein histidine kinase activity
GPY59_RS11380	COG2198	Histidine kinase
GPY59_RS11380	COG0784	Response regulator, receiver
GPY59_RS11390	COG0745	RESPONSE REGULATOR receiver
GPY59_RS11405	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GPY59_RS11425	COG0083	homoserine kinase activity
GPY59_RS11430	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GPY59_RS11440	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
GPY59_RS11445	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GPY59_RS11455	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GPY59_RS11470	COG1115	amino acid carrier protein
GPY59_RS11475	COG3022	response to hydroperoxide
GPY59_RS11480	COG0513	Belongs to the DEAD box helicase family
GPY59_RS11485	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GPY59_RS11495	COG0716	FMN binding
GPY59_RS11505	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPY59_RS11510	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GPY59_RS11525	COG2204	response regulator
GPY59_RS11535	COG0667	Aldo Keto reductase
GPY59_RS11565	COG0730	response to heat
GPY59_RS11575	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GPY59_RS11585	COG1283	sodium-dependent phosphate transmembrane transporter activity
GPY59_RS11590	COG0583	DNA-binding transcription factor activity
GPY59_RS11595	COG0640	Transcriptional regulator
GPY59_RS11600	COG0268	Binds directly to 16S ribosomal RNA
GPY59_RS11605	COG0728	peptidoglycan biosynthetic process
GPY59_RS11610	COG0196	riboflavin kinase activity
GPY59_RS11625	COG1047	Peptidyl-prolyl cis-trans
GPY59_RS11630	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GPY59_RS11640	COG3279	Response regulator of the LytR AlgR family
GPY59_RS11645	COG3275	phosphorelay sensor kinase activity
GPY59_RS11650	COG1966	Carbon starvation protein
GPY59_RS11670	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GPY59_RS11675	COG1472	Belongs to the glycosyl hydrolase 3 family
GPY59_RS11680	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY59_RS11685	COG0287	Prephenate dehydrogenase
GPY59_RS11685	COG1605	Chorismate mutase
GPY59_RS11690	COG0739	heme binding
GPY59_RS11700	COG0488	(ABC) transporter
GPY59_RS11710	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
GPY59_RS11715	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
GPY59_RS11720	COG1605	Chorismate mutase
GPY59_RS11720	COG0077	Prephenate dehydratase
GPY59_RS11725	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GPY59_RS11735	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY59_RS11740	COG0564	pseudouridine synthase activity
GPY59_RS11750	COG0542	response to heat
GPY59_RS11810	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GPY59_RS11820	COG2974	May be involved in recombination
GPY59_RS11825	COG0745	RESPONSE REGULATOR receiver
GPY59_RS11830	COG5002	protein histidine kinase activity
GPY59_RS11840	COG0248	Ppx GppA phosphatase
GPY59_RS11845	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GPY59_RS11850	COG0573	inorganic phosphate transmembrane transporter activity
GPY59_RS11855	COG0581	inorganic phosphate transmembrane transporter activity
GPY59_RS11860	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GPY59_RS11865	COG0704	Plays a role in the regulation of phosphate uptake
GPY59_RS11875	COG3142	Participates in the control of copper homeostasis
GPY59_RS11880	COG0450	alkyl hydroperoxide reductase
GPY59_RS11885	COG0583	DNA-binding transcription factor activity
GPY59_RS11895	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GPY59_RS11905	COG0517	IMP dehydrogenase activity
GPY59_RS11915	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GPY59_RS11925	COG1862	Preprotein translocase
GPY59_RS11930	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY59_RS11935	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY59_RS11950	COG0483	inositol monophosphate 1-phosphatase activity
GPY59_RS11955	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
GPY59_RS11965	COG1104	cysteine desulfurase activity
GPY59_RS11970	COG0822	iron-sulfur transferase activity
GPY59_RS11985	COG0443	Heat shock 70 kDa protein
GPY59_RS11990	COG0633	Ferredoxin
GPY59_RS11995	COG2975	iron-sulfur cluster assembly
GPY59_RS12005	COG0105	UTP biosynthetic process
GPY59_RS12020	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GPY59_RS12025	COG0124	histidyl-tRNA synthetase
GPY59_RS12030	COG2976	Protein conserved in bacteria
GPY59_RS12035	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY59_RS12040	COG1160	GTP binding
GPY59_RS12060	COG0516	GMP reductase activity
GPY59_RS12060	COG0517	IMP dehydrogenase activity
GPY59_RS12070	COG1757	Na H antiporter
GPY59_RS12080	COG1584	GPR1 FUN34 yaaH family protein
GPY59_RS12085	COG1115	amino acid carrier protein
GPY59_RS12090	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPY59_RS12100	COG2873	o-acetylhomoserine
GPY59_RS12105	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GPY59_RS12125	COG3153	acetyltransferase
GPY59_RS12125	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GPY59_RS12130	COG0583	DNA-binding transcription factor activity
GPY59_RS12180	COG2003	Belongs to the UPF0758 family
GPY59_RS12200	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GPY59_RS12220	COG0582	viral genome integration into host DNA
GPY59_RS12230	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GPY59_RS12235	COG2867	negative regulation of translational initiation
GPY59_RS12240	COG2914	Belongs to the UPF0125 (RnfH) family
GPY59_RS12245	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY59_RS12255	COG0497	DNA recombination
GPY59_RS12265	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GPY59_RS12270	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GPY59_RS12275	COG1301	dicarboxylic acid transport
GPY59_RS12285	COG0484	heat shock protein binding
GPY59_RS12320	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPY59_RS12325	COG0590	tRNA wobble adenosine to inosine editing
GPY59_RS12335	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GPY59_RS12340	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GPY59_RS12340	COG0047	phosphoribosylformylglycinamidine synthase activity
GPY59_RS12370	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPY59_RS12375	COG2252	PERMEase
GPY59_RS12380	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
GPY59_RS12395	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GPY59_RS12400	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GPY59_RS12405	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GPY59_RS12410	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPY59_RS12410	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPY59_RS12435	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GPY59_RS12440	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GPY59_RS12445	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GPY59_RS12450	COG0142	geranyltranstransferase activity
GPY59_RS12455	COG1722	exodeoxyribonuclease VII activity
GPY59_RS12460	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GPY59_RS12470	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY59_RS12470	COG0301	tRNA thio-modification
GPY59_RS12475	COG0583	DNA-binding transcription factor activity
GPY59_RS12485	COG2363	Small membrane protein
GPY59_RS12495	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPY59_RS12500	COG1611	Belongs to the LOG family
GPY59_RS12505	COG0745	RESPONSE REGULATOR receiver
GPY59_RS12505	COG3706	GGDEF domain
GPY59_RS12515	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GPY59_RS12515	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GPY59_RS12525	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
GPY59_RS12530	COG1464	Belongs to the NlpA lipoprotein family
GPY59_RS12535	COG2011	ABC-type metal ion transport system permease component
GPY59_RS12540	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GPY59_RS12545	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GPY59_RS12555	COG1263	PTS System
GPY59_RS12555	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY59_RS12560	COG0366	Alpha amylase catalytic
GPY59_RS12575	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GPY59_RS12580	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GPY59_RS12585	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GPY59_RS12590	COG0321	lipoyl(octanoyl) transferase activity
GPY59_RS12600	COG1686	Belongs to the peptidase S11 family
GPY59_RS12605	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GPY59_RS12610	COG0772	Belongs to the SEDS family
GPY59_RS12615	COG0768	penicillin binding
GPY59_RS12620	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GPY59_RS12625	COG0799	negative regulation of ribosome biogenesis
GPY59_RS12630	COG1466	dna polymerase III delta subunit
GPY59_RS12635	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
GPY59_RS12640	COG0495	leucyl-tRNA aminoacylation
GPY59_RS12645	COG2888	peptidyl-tyrosine sulfation
GPY59_RS12650	COG1943	Transposase
GPY59_RS12655	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GPY59_RS12660	COG4535	Mg2 and Co2 transporter CorC
GPY59_RS12665	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GPY59_RS12670	COG1702	phosphate starvation-inducible protein PhoH
GPY59_RS12675	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GPY59_RS12685	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPY59_RS12795	COG0012	GTP binding
GPY59_RS12800	COG0193	aminoacyl-tRNA hydrolase activity
GPY59_RS12805	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GPY59_RS12810	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GPY59_RS12815	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
GPY59_RS12820	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GPY59_RS12830	COG2890	protein-(glutamine-N5) methyltransferase activity
GPY59_RS12835	COG3094	Invasion gene expression up-regulator, SirB
GPY59_RS12840	COG2912	Transglutaminase-like superfamily
GPY59_RS12845	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GPY59_RS12850	COG0737	Belongs to the 5'-nucleotidase family
GPY59_RS12855	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GPY59_RS12860	COG1187	pseudouridine synthase activity
GPY59_RS12865	COG2840	Smr protein MutS2
GPY59_RS12905	COG2217	Heavy metal translocating P-type atpase
GPY59_RS12905	COG2608	mercury ion transmembrane transporter activity
GPY59_RS12920	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GPY59_RS12975	COG0835	chemotaxis
GPY59_RS12975	COG0784	Response regulator, receiver
GPY59_RS12980	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GPY59_RS12985	COG1815	bacterial-type flagellum-dependent cell motility
GPY59_RS12990	COG1558	bacterial-type flagellum-dependent cell motility
GPY59_RS12995	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GPY59_RS13000	COG1749	Flagellar hook protein flgE
GPY59_RS13005	COG4787	bacterial-type flagellum-dependent cell motility
GPY59_RS13010	COG4786	Flagellar basal body rod
GPY59_RS13015	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GPY59_RS13020	COG1706	bacterial-type flagellum-dependent cell motility
GPY59_RS13025	COG1705	Flagellar rod assembly protein muramidase FlgJ
GPY59_RS13025	COG3951	Flagellar rod assembly protein muramidase FlgJ
GPY59_RS13035	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY59_RS13040	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY59_RS13050	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY59_RS13055	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY59_RS13065	COG2190	(PTS) system
GPY59_RS13070	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GPY59_RS13075	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY59_RS13085	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GPY59_RS13090	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
GPY59_RS13095	COG3115	cell septum assembly
GPY59_RS13100	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GPY59_RS13115	COG0330	HflC and HflK could
GPY59_RS13120	COG3118	belongs to the thioredoxin family
GPY59_RS13130	COG0300	oxidoreductase activity
GPY59_RS13135	COG1090	epimerase
GPY59_RS13165	COG0622	Phosphoesterase
GPY59_RS13185	COG3710	Transcriptional regulator
GPY59_RS13190	COG0326	Molecular chaperone. Has ATPase activity
GPY59_RS13200	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GPY59_RS13205	COG3104	oligopeptide transport
GPY59_RS13210	COG0250	Participates in transcription elongation, termination and antitermination
GPY59_RS13215	COG0367	asparagine synthase
GPY59_RS13220	COG4651	solute:proton antiporter activity
GPY59_RS13220	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GPY59_RS13225	COG1940	carbohydrate kinase activity
GPY59_RS13225	COG1846	Transcriptional regulator
GPY59_RS13230	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GPY59_RS13240	COG2190	(PTS) system
GPY59_RS13240	COG1263	PTS System
GPY59_RS13240	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY59_RS13245	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPY59_RS13250	COG0735	belongs to the Fur family
GPY59_RS13260	COG0716	FMN binding
GPY59_RS13270	COG0596	Alpha beta hydrolase
GPY59_RS13275	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
GPY59_RS13280	COG0033	Phosphoglucomutase
GPY59_RS13290	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GPY59_RS13300	COG2009	succinate dehydrogenase
GPY59_RS13305	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GPY59_RS13310	COG1053	succinate dehydrogenase
GPY59_RS13315	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GPY59_RS13320	COG0567	Dehydrogenase, E1 component
GPY59_RS13325	COG0508	dehydrogenase complex catalyzes the overall conversion of
GPY59_RS13330	COG0045	succinate-CoA ligase (ADP-forming) activity
GPY59_RS13340	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GPY59_RS13345	COG1121	(ABC) transporter
GPY59_RS13350	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
GPY59_RS13355	COG4977	sequence-specific DNA binding
GPY59_RS13360	COG1918	ferrous iron import across plasma membrane
GPY59_RS13385	COG0018	arginyl-trna synthetase
GPY59_RS13395	COG3102	Protein conserved in bacteria
GPY59_RS13400	COG0788	formyltetrahydrofolate deformylase activity
GPY59_RS13405	COG1199	ATP-dependent helicase activity
GPY59_RS13410	COG1214	PFAM Peptidase M22, glycoprotease
GPY59_RS13420	COG3065	identical protein binding
GPY59_RS13425	COG2267	carboxylic ester hydrolase activity
GPY59_RS13430	COG0318	PFAM AMP-dependent synthetase and ligase
GPY59_RS13435	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GPY59_RS13445	COG2894	cell division
GPY59_RS13450	COG0850	regulation of cytokinetic process
GPY59_RS13455	COG3100	YcgL domain-containing protein
GPY59_RS13460	COG2951	lytic endotransglycosylase activity
GPY59_RS13470	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPY59_RS13475	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GPY59_RS13485	COG2226	methyltransferase
GPY59_RS13490	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPY59_RS13495	COG1028	Short-chain dehydrogenase reductase Sdr
GPY59_RS13500	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPY59_RS13505	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPY59_RS13530	COG2986	histidine ammonia-lyase
GPY59_RS13535	COG1216	Glycosyl transferase, family 2
GPY59_RS13540	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPY59_RS13555	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GPY59_RS13560	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GPY59_RS13595	COG0513	Belongs to the DEAD box helicase family
GPY59_RS13600	COG0569	domain protein
GPY59_RS13605	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY59_RS13620	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GPY59_RS13625	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GPY59_RS13630	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GPY59_RS13635	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GPY59_RS13650	COG0544	peptidyl-prolyl cis-trans isomerase activity
GPY59_RS13660	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GPY59_RS13665	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GPY59_RS13670	COG0776	regulation of translation
GPY59_RS13675	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPY59_RS13680	COG1555	photosystem II stabilization
GPY59_RS13695	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GPY59_RS13700	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
GPY59_RS13705	COG0436	Aminotransferase
GPY59_RS13710	COG1169	isochorismate synthase
GPY59_RS13715	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GPY59_RS13725	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GPY59_RS13730	COG1441	menaquinone biosynthetic process
GPY59_RS13745	COG2855	membrane
GPY59_RS13750	COG0477	Major facilitator Superfamily
GPY59_RS13795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY59_RS13800	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY59_RS13815	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GPY59_RS13820	COG1522	sequence-specific DNA binding
GPY59_RS13830	COG1946	Acyl-CoA thioesterase
GPY59_RS13835	COG3126	Type III secretion system lipoprotein chaperone (YscW)
GPY59_RS13850	COG3706	GGDEF domain
GPY59_RS13860	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPY59_RS13865	COG0516	GMP reductase activity
GPY59_RS13865	COG0517	IMP dehydrogenase activity
GPY59_RS13890	COG0537	adenosine 5'-monophosphoramidase activity
GPY59_RS13915	COG3150	esterase
GPY59_RS13920	COG1252	NADH dehydrogenase
GPY59_RS13935	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GPY59_RS13945	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPY59_RS13950	COG1136	(ABC) transporter
GPY59_RS13955	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPY59_RS13965	COG0658	competence protein
GPY59_RS13965	COG2333	competence protein COMEC
GPY59_RS13970	COG1132	(ABC) transporter
GPY59_RS13990	COG2719	SpoVR family
GPY59_RS13995	COG2718	Belongs to the UPF0229 family
GPY59_RS14000	COG2766	serine protein kinase
GPY59_RS14005	COG3013	Belongs to the UPF0304 family
GPY59_RS14015	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GPY59_RS14025	COG1882	Formate acetyltransferase
GPY59_RS14055	COG4215	(ABC) transporter
GPY59_RS14070	COG0708	Exodeoxyribonuclease III
GPY59_RS14080	COG3923	Primosomal replication protein n
GPY59_RS14085	COG0730	response to heat
GPY59_RS14090	COG1199	ATP-dependent helicase activity
GPY59_RS14095	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPY59_RS14100	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GPY59_RS14105	COG1187	pseudouridine synthase activity
GPY59_RS14115	COG1278	Cold shock
GPY59_RS14120	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GPY59_RS14125	COG0542	response to heat
GPY59_RS14130	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GPY59_RS14135	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
GPY59_RS14140	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GPY59_RS14160	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GPY59_RS14165	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GPY59_RS14170	COG0297	glycogen (starch) synthase activity
GPY59_RS14190	COG3070	regulator of competence-specific genes
GPY59_RS14195	COG1609	Transcriptional regulator
GPY59_RS14200	COG3381	protein complex oligomerization
GPY59_RS14205	COG0745	RESPONSE REGULATOR receiver
GPY59_RS14210	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GPY59_RS14215	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPY59_RS14220	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
GPY59_RS14225	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
GPY59_RS14230	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GPY59_RS14250	COG0189	ligase activity
GPY59_RS14250	COG4067	protein conserved in archaea
GPY59_RS14260	COG0500	methyltransferase
GPY59_RS14270	COG1801	Protein of unknown function DUF72
GPY59_RS14280	COG0217	transcriptional regulatory protein
GPY59_RS14285	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GPY59_RS14290	COG0632	four-way junction helicase activity
GPY59_RS14295	COG2255	four-way junction helicase activity
GPY59_RS14300	COG1271	oxidase subunit
GPY59_RS14305	COG1294	oxidase, subunit
GPY59_RS14310	COG4890	Cyd operon protein YbgT
GPY59_RS14320	COG0824	Thioesterase
GPY59_RS14325	COG0811	peptide transport
GPY59_RS14340	COG0823	Involved in the tonB-independent uptake of proteins
GPY59_RS14345	COG2885	chlorophyll binding
GPY59_RS14350	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
GPY59_RS14355	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GPY59_RS14365	COG3766	membrane
GPY59_RS14375	COG0754	glutathionylspermidine amidase activity
GPY59_RS14385	COG0784	Response regulator, receiver
GPY59_RS14385	COG5002	protein histidine kinase activity
GPY59_RS14415	COG0328	RNA-DNA hybrid ribonuclease activity
GPY59_RS14435	COG1294	oxidase, subunit
GPY59_RS14440	COG1271	oxidase subunit
GPY59_RS14460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY59_RS14465	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY59_RS14490	COG3568	Endonuclease Exonuclease Phosphatase
GPY59_RS14515	COG0583	DNA-binding transcription factor activity
GPY59_RS14525	COG0686	Belongs to the AlaDH PNT family
GPY59_RS14535	COG1674	ftsk spoiiie
GPY59_RS14545	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GPY59_RS14565	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GPY59_RS14590	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GPY59_RS14610	COG0300	oxidoreductase activity
GPY59_RS14625	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GPY59_RS14635	COG2268	Band 7 protein
GPY59_RS14645	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GPY59_RS14650	COG2915	High frequency lysogenization protein hflD homolog
GPY59_RS14665	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY59_RS14675	COG1757	Na H antiporter
GPY59_RS14685	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GPY59_RS14695	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GPY59_RS14695	COG0131	Imidazoleglycerol-phosphate dehydratase
GPY59_RS14700	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GPY59_RS14705	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GPY59_RS14710	COG0107	imidazoleglycerol-phosphate synthase activity
GPY59_RS14715	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GPY59_RS14715	COG0140	phosphoribosyl-ATP diphosphatase activity
GPY59_RS14720	COG3012	SEC-C Motif Domain Protein
GPY59_RS14725	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GPY59_RS14730	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY59_RS14735	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GPY59_RS14740	COG0215	cysteine-tRNA ligase activity
GPY59_RS14745	COG1435	thymidine kinase activity
GPY59_RS14750	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GPY59_RS14775	COG2116	formate transmembrane transporter activity
GPY59_RS14785	COG0390	transport system, permease component
GPY59_RS14790	COG4459	periplasmic nitrate reductase
GPY59_RS14795	COG3005	denitrification pathway
GPY59_RS14800	COG0243	molybdopterin cofactor binding
GPY59_RS14815	COG1227	inorganic diphosphatase activity
GPY59_RS14825	COG4172	Belongs to the ABC transporter superfamily
GPY59_RS14835	COG4171	peptide transport system, permease
GPY59_RS14840	COG4168	peptide transport system, permease
GPY59_RS14850	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GPY59_RS14855	COG1842	Phage shock protein A
GPY59_RS14865	COG1983	PspC domain protein
GPY59_RS14885	COG2818	Glycosylase
GPY59_RS14890	COG5380	lipid catabolic process
GPY59_RS14895	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GPY59_RS14900	COG0626	cystathionine gamma-synthase activity
GPY59_RS14910	COG0733	neurotransmitter:sodium symporter activity
GPY59_RS14915	COG0564	pseudouridine synthase activity
GPY59_RS14925	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPY59_RS14930	COG1151	hydroxylamine reductase activity
GPY59_RS14935	COG3604	Transcriptional regulator
GPY59_RS14950	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GPY59_RS14955	COG4136	ATPase activity
GPY59_RS14960	COG4135	transport system, permease component
GPY59_RS14965	COG4134	Bacterial extracellular solute-binding protein
GPY59_RS14975	COG3313	Fe-S protein
GPY59_RS15000	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GPY59_RS15005	COG2205	protein histidine kinase activity
GPY59_RS15010	COG0745	RESPONSE REGULATOR receiver
GPY59_RS15020	COG1061	Type III restriction enzyme res subunit
GPY59_RS15025	COG1187	pseudouridine synthase activity
GPY59_RS15030	COG2814	Major facilitator Superfamily
GPY59_RS15040	COG0702	epimerase
GPY59_RS15045	COG0534	Mate efflux family protein
GPY59_RS15065	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GPY59_RS15075	COG1960	acyl-CoA dehydrogenase activity
GPY59_RS15080	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GPY59_RS15085	COG3273	potassium ion transport
GPY59_RS15085	COG2985	domain, Protein
GPY59_RS15090	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPY59_RS15100	COG1737	Transcriptional regulator
GPY59_RS15105	COG0076	glutamate decarboxylase activity
GPY59_RS15115	COG2431	L-lysine efflux transmembrane transporter activity
GPY59_RS15130	COG3070	regulator of competence-specific genes
GPY59_RS15145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY59_RS15145	COG4191	Histidine kinase
GPY59_RS15155	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GPY59_RS15165	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GPY59_RS15170	COG4988	ABC transporter
GPY59_RS15175	COG0492	ferredoxin-NADP+ reductase activity
GPY59_RS15195	COG3706	GGDEF domain
GPY59_RS15195	COG0745	RESPONSE REGULATOR receiver
GPY59_RS15200	COG0471	metal ion transport
GPY59_RS15205	COG2949	membrane
GPY59_RS15210	COG0281	malic enzyme
GPY59_RS15215	COG1643	Atp-dependent helicase
GPY59_RS15230	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GPY59_RS15265	COG0277	FAD linked oxidase domain protein
GPY59_RS15265	COG0247	lactate metabolic process
GPY59_RS15280	COG2986	histidine ammonia-lyase
GPY59_RS15285	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GPY59_RS15290	COG0010	Belongs to the arginase family
GPY59_RS15295	COG1228	amidohydrolase
GPY59_RS15315	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GPY59_RS15325	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GPY59_RS15335	COG0393	Putative heavy-metal-binding
GPY59_RS15370	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GPY59_RS15375	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY59_RS15375	COG0072	phenylalanine-tRNA ligase activity
GPY59_RS15385	COG0776	regulation of translation
GPY59_RS15395	COG0500	methyltransferase
GPY59_RS15400	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GPY59_RS15405	COG0295	cytidine deaminase activity
GPY59_RS15410	COG1346	cytolysis
GPY59_RS15415	COG1380	Effector of murein hydrolase LrgA
GPY59_RS15420	COG2925	Exonuclease
GPY59_RS15430	COG0702	epimerase
GPY59_RS15435	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GPY59_RS15440	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
GPY59_RS15460	COG2988	succinylglutamate desuccinylase activity
GPY59_RS15465	COG4139	cobalamin transport
GPY59_RS15470	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
GPY59_RS15490	COG0583	DNA-binding transcription factor activity
GPY59_RS15500	COG1451	nucleotide metabolic process
GPY59_RS15505	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
GPY59_RS15535	COG3938	Belongs to the proline racemase family
GPY59_RS15550	COG2423	ornithine cyclodeaminase activity
GPY59_RS15555	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GPY59_RS15560	COG3842	ATPase activity
GPY59_RS15565	COG1176	ABC-type spermidine putrescine transport system, permease component I
GPY59_RS15570	COG1177	transmembrane transport
GPY59_RS15580	COG3291	Pkd domain containing protein
GPY59_RS15600	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY59_RS15605	COG0601	transmembrane transport
GPY59_RS15615	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPY59_RS15625	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GPY59_RS15635	COG0625	glutathione transferase activity
GPY59_RS15685	COG3755	Protein conserved in bacteria
GPY59_RS15710	COG1742	UPF0060 membrane protein
GPY59_RS15725	COG1757	Na H antiporter
GPY59_RS15730	COG0174	glutamine synthetase
GPY59_RS15740	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GPY59_RS15745	COG1917	Cupin 2, conserved barrel domain protein
GPY59_RS15745	COG1396	sequence-specific DNA binding
GPY59_RS15750	COG1012	belongs to the aldehyde dehydrogenase family
GPY59_RS15755	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPY59_RS15765	COG2957	Belongs to the agmatine deiminase family
GPY59_RS15770	COG1012	belongs to the aldehyde dehydrogenase family
GPY59_RS15775	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GPY59_RS15780	COG2200	EAL domain
GPY59_RS15790	COG1846	Transcriptional regulator
GPY59_RS15795	COG2315	Protein conserved in bacteria
GPY59_RS15835	COG3063	Type IV pilus biogenesis stability protein PilW
GPY59_RS15840	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GPY59_RS15855	COG1560	Kdo2-lipid A biosynthetic process
GPY59_RS15860	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GPY59_RS15865	COG1280	lysine exporter protein (LysE YggA)
GPY59_RS15875	COG1115	amino acid carrier protein
GPY59_RS15900	COG1368	sulfuric ester hydrolase activity
GPY59_RS15905	COG2113	Glycine betaine
GPY59_RS15910	COG4176	ABC-type proline glycine betaine transport system permease component
GPY59_RS15915	COG4175	Glycine betaine
GPY59_RS15930	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPY59_RS15935	COG0456	acetyltransferase
GPY59_RS15940	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GPY59_RS15945	COG0662	Cupin 2, conserved barrel domain protein
GPY59_RS15950	COG0527	aspartate kinase activity
GPY59_RS15955	COG3119	arylsulfatase activity
GPY59_RS15970	COG0641	radical SAM
GPY59_RS15985	COG3119	arylsulfatase activity
GPY59_RS16010	COG1538	Outer membrane efflux protein
GPY59_RS16025	COG1349	DNA-binding transcription factor activity
GPY59_RS16030	COG0673	inositol 2-dehydrogenase activity
GPY59_RS16035	COG4702	Belongs to the UPF0303 family
GPY59_RS16040	COG3706	GGDEF domain
GPY59_RS16040	COG0745	RESPONSE REGULATOR receiver
GPY59_RS16060	COG0471	metal ion transport
GPY59_RS16075	COG5001	Diguanylate cyclase
GPY59_RS16075	COG3300	MHYT domain
GPY59_RS16090	COG1328	CTP reductase activity
GPY59_RS16095	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GPY59_RS16105	COG0861	Integral membrane protein TerC family
GPY59_RS16115	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GPY59_RS16125	COG0814	amino acid
GPY59_RS16140	COG1120	ATPase activity
GPY59_RS16145	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GPY59_RS16155	COG4774	siderophore transport
GPY59_RS16165	COG1132	(ABC) transporter
GPY59_RS16170	COG1132	(ABC) transporter
GPY59_RS16185	COG0583	DNA-binding transcription factor activity
GPY59_RS16210	COG0443	Heat shock 70 kDa protein
GPY59_RS16215	COG0443	Heat shock 70 kDa protein
GPY59_RS16260	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GPY59_RS16265	COG1643	Atp-dependent helicase
GPY59_RS16280	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPY59_RS16290	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GPY59_RS16295	COG1215	transferase activity, transferring glycosyl groups
GPY59_RS16300	COG0438	transferase activity, transferring glycosyl groups
GPY59_RS16330	COG0438	transferase activity, transferring glycosyl groups
GPY59_RS16340	COG2204	response regulator
GPY59_RS16370	COG1793	dna ligase
GPY59_RS16380	COG0534	Mate efflux family protein
GPY59_RS16385	COG0307	riboflavin synthase, alpha
GPY59_RS16405	COG3706	GGDEF domain
GPY59_RS16415	COG0791	NLP P60 protein
GPY59_RS16450	COG1940	carbohydrate kinase activity
GPY59_RS16460	COG0303	'Molybdopterin
GPY59_RS16465	COG0746	molybdenum cofactor guanylyltransferase activity
GPY59_RS16470	COG3842	ATPase activity
GPY59_RS16485	COG2204	response regulator
GPY59_RS16490	COG4191	Histidine kinase
GPY59_RS16500	COG0488	(ABC) transporter
GPY59_RS16505	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GPY59_RS16535	COG0243	molybdopterin cofactor binding
GPY59_RS16535	COG3383	formate dehydrogenase (NAD+) activity
GPY59_RS16540	COG0437	4 iron, 4 sulfur cluster binding
GPY59_RS16570	COG0004	ammonium transporteR
GPY59_RS16575	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GPY59_RS16580	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY59_RS16585	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY59_RS16590	COG1177	transmembrane transport
GPY59_RS16595	COG1176	ABC-type spermidine putrescine transport system, permease component I
GPY59_RS16600	COG3842	ATPase activity
GPY59_RS16625	COG0589	response to stress
GPY59_RS16630	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY59_RS16645	COG2217	Heavy metal translocating P-type atpase
GPY59_RS16655	COG2010	Cytochrome c
GPY59_RS16670	COG3278	Belongs to the heme-copper respiratory oxidase family
GPY59_RS16685	COG0784	Response regulator, receiver
GPY59_RS16685	COG2205	protein histidine kinase activity
GPY59_RS16825	COG3120	sequence-specific DNA binding
GPY59_RS16830	COG1067	ATP-dependent peptidase activity
GPY59_RS16835	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPY59_RS16860	COG0116	Belongs to the methyltransferase superfamily
GPY59_RS16860	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GPY59_RS16870	COG0167	dihydroorotate dehydrogenase activity
GPY59_RS16875	COG2902	Dehydrogenase
GPY59_RS16885	COG0308	aminopeptidase N
GPY59_RS16900	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
GPY59_RS16905	COG1956	GAF domain-containing protein
GPY59_RS16910	COG1132	(ABC) transporter
GPY59_RS16915	COG2995	paraquat-inducible protein a
GPY59_RS16920	COG3008	intermembrane lipid transfer
GPY59_RS16945	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY59_RS16950	COG1666	GTP binding
GPY59_RS16960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY59_RS16965	COG4597	amino acid ABC transporter
GPY59_RS16970	COG0765	amino acid transport
GPY59_RS16975	COG1126	abc transporter atp-binding protein
GPY59_RS16980	COG0670	Belongs to the BI1 family
GPY59_RS16990	COG2920	part of a sulfur-relay system
GPY59_RS16995	COG1254	Belongs to the acylphosphatase family
GPY59_RS17000	COG0840	transmembrane signaling receptor activity
GPY59_RS17020	COG2885	chlorophyll binding
GPY59_RS17045	COG2199	diguanylate cyclase activity
GPY59_RS17045	COG2203	Gaf domain
GPY59_RS17050	COG1414	Transcriptional regulator
GPY59_RS17060	COG0656	L-ascorbic acid biosynthetic process
GPY59_RS17065	COG0583	DNA-binding transcription factor activity
GPY59_RS17075	COG0583	DNA-binding transcription factor activity
GPY59_RS17080	COG2814	Major facilitator Superfamily
GPY59_RS17100	COG1335	isochorismatase
GPY59_RS17120	COG1410	methionine synthase
GPY59_RS17120	COG0646	methionine synthase
GPY59_RS17125	COG1126	abc transporter atp-binding protein
GPY59_RS17130	COG0765	amino acid transport
GPY59_RS17135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY59_RS17150	COG0583	DNA-binding transcription factor activity
GPY59_RS17165	COG0583	DNA-binding transcription factor activity
GPY59_RS17170	COG0583	DNA-binding transcription factor activity
GPY59_RS17185	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GPY59_RS17190	COG0602	queuosine metabolic process
GPY59_RS17195	COG0561	phosphatase activity
GPY59_RS17220	COG2828	Protein conserved in bacteria
GPY59_RS17230	COG0372	Belongs to the citrate synthase family
GPY59_RS17235	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GPY59_RS17270	COG0730	response to heat
GPY59_RS17295	COG0457	Tetratricopeptide repeat
GPY59_RS17360	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GPY59_RS17365	COG4790	Type iii secretion
GPY59_RS17370	COG4794	Type iii secretion
GPY59_RS17375	COG4791	protein targeting
GPY59_RS17380	COG4792	protein secretion
GPY59_RS17385	COG2207	Transcriptional regulator
GPY59_RS17415	COG3177	Filamentation induced by cAMP protein fic
GPY59_RS17435	COG4669	(LipO)protein
GPY59_RS17505	COG1012	belongs to the aldehyde dehydrogenase family
GPY59_RS17510	COG3284	Transcriptional regulator
GPY59_RS17525	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GPY59_RS17530	COG0363	glucosamine-6-phosphate deaminase activity
GPY59_RS17535	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GPY59_RS17540	COG2207	Transcriptional regulator
GPY59_RS17550	COG4565	transcriptional regulatory protein
GPY59_RS17555	COG3290	protein histidine kinase activity
GPY59_RS17570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY59_RS17600	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
GPY59_RS17610	COG2985	domain, Protein
GPY59_RS17635	COG2272	Belongs to the type-B carboxylesterase lipase family
GPY59_RS17640	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GPY59_RS17645	COG0729	surface antigen
GPY59_RS17655	COG1280	lysine exporter protein (LysE YggA)
GPY59_RS17660	COG1280	lysine exporter protein (LysE YggA)
GPY59_RS17665	COG5507	3-demethylubiquinone-9 3-methyltransferase
GPY59_RS17685	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GPY59_RS17690	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY59_RS17695	COG0110	maltose O-acetyltransferase activity
GPY59_RS17770	COG1028	Short-chain dehydrogenase reductase Sdr
GPY59_RS17825	COG2824	Alkylphosphonate utilization operon protein PhnA
GPY59_RS17950	COG2026	Addiction module toxin, RelE StbE family
GPY59_RS18010	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GPY59_RS18415	COG1714	RDD family
GPY59_RS18755	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY59_RS18765	COG3768	UPF0283 membrane protein
GPY59_RS18770	COG3106	COG3106 Predicted ATPase
GPY59_RS18795	COG2205	protein histidine kinase activity
GPY59_RS18795	COG0784	Response regulator, receiver
GPY59_RS18805	COG0494	nUDIX hydrolase
GPY59_RS18810	COG0814	amino acid
GPY59_RS18815	COG1760	l-serine dehydratase
GPY59_RS18820	COG2200	EAL domain
GPY59_RS18830	COG0720	synthase
GPY59_RS18835	COG0840	transmembrane signaling receptor activity
GPY59_RS18840	COG0017	Asparaginyl-tRNA synthetase
GPY59_RS18850	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY59_RS18865	COG1448	Aminotransferase
GPY59_RS18885	COG0840	transmembrane signaling receptor activity
GPY59_RS18890	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPY59_RS18920	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GPY59_RS18935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPY59_RS18940	COG3108	Peptidase M15
GPY59_RS18945	COG2989	Protein conserved in bacteria
GPY59_RS18970	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GPY59_RS18980	COG4235	cytochrome complex assembly
GPY59_RS18980	COG3088	subunit of a heme lyase
GPY59_RS18990	COG1138	Cytochrome C-type biogenesis protein
GPY59_RS18995	COG3301	Polysulphide reductase, NrfD
GPY59_RS19000	COG0437	4 iron, 4 sulfur cluster binding
GPY59_RS19010	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
GPY59_RS19030	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPY59_RS19035	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GPY59_RS19040	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GPY59_RS19065	COG0019	diaminopimelate decarboxylase activity
GPY59_RS19105	COG0322	excinuclease ABC activity
GPY59_RS19110	COG2197	response regulator
GPY59_RS19115	COG0417	DNA replication proofreading
GPY59_RS19135	COG1187	pseudouridine synthase activity
GPY59_RS19145	COG0009	L-threonylcarbamoyladenylate synthase
GPY59_RS19150	COG0613	PHP domain protein
GPY59_RS19160	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GPY59_RS19165	COG0512	Glutamine amidotransferase of anthranilate synthase
GPY59_RS19175	COG0134	indole-3-glycerol-phosphate synthase activity
GPY59_RS19175	COG0135	phosphoribosylanthranilate isomerase activity
GPY59_RS19185	COG0159	tryptophan synthase activity
GPY59_RS19190	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY59_RS19195	COG0318	PFAM AMP-dependent synthetase and ligase
GPY59_RS19200	COG1301	dicarboxylic acid transport
GPY59_RS19220	COG2917	probably involved in intracellular septation
GPY59_RS19225	COG1607	acyl-coa hydrolase
GPY59_RS19230	COG2350	Protein conserved in bacteria
GPY59_RS19240	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GPY59_RS19245	COG0583	DNA-binding transcription factor activity
GPY59_RS19260	COG5001	Diguanylate cyclase
GPY59_RS19265	COG1032	radical SAM domain protein
GPY59_RS19310	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GPY59_RS19315	COG0463	Glycosyl transferase, family 2
GPY59_RS19320	COG0745	RESPONSE REGULATOR receiver
GPY59_RS19325	COG3850	Histidine kinase
GPY59_RS19325	COG5002	protein histidine kinase activity
GPY59_RS19360	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GPY59_RS19420	COG1136	(ABC) transporter
GPY59_RS19420	COG0577	efflux transmembrane transporter activity
GPY59_RS19425	COG1136	(ABC) transporter
GPY59_RS19425	COG0577	efflux transmembrane transporter activity
GPY59_RS19430	COG0577	efflux transmembrane transporter activity
GPY59_RS19430	COG1136	(ABC) transporter
GPY59_RS19440	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY59_RS19460	COG3118	belongs to the thioredoxin family
GPY59_RS19465	COG4232	protein-disulfide reductase activity
GPY59_RS19500	COG2863	cytochrome
GPY59_RS19505	COG3258	Cytochrome c
GPY59_RS19510	COG2995	paraquat-inducible protein a
GPY59_RS19515	COG3008	intermembrane lipid transfer
GPY59_RS19515	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GPY59_RS19535	COG4166	transmembrane transport
GPY59_RS19545	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
GPY59_RS19550	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
GPY59_RS19560	COG0539	negative regulation of cytoplasmic translation
GPY59_RS19565	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GPY59_RS19570	COG0616	signal peptide processing
GPY59_RS19575	COG1028	Short-chain dehydrogenase reductase Sdr
GPY59_RS19590	COG0587	DNA-directed DNA polymerase activity
GPY59_RS19595	COG0835	chemotaxis
GPY59_RS19595	COG0784	Response regulator, receiver
GPY59_RS19600	COG1940	carbohydrate kinase activity
GPY59_RS19605	COG0469	pyruvate kinase activity
GPY59_RS19610	COG4667	esterase of the alpha-beta hydrolase superfamily
GPY59_RS19625	COG0733	neurotransmitter:sodium symporter activity
GPY59_RS19640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY59_RS19640	COG1263	PTS System
GPY59_RS19645	COG0084	hydrolase, TatD family'
GPY59_RS19650	COG0470	DNA polymerase III
GPY59_RS19655	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GPY59_RS19660	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GPY59_RS19690	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GPY59_RS19695	COG0416	fatty acid biosynthetic process
GPY59_RS19705	COG1399	metal-binding, possibly nucleic acid-binding protein
GPY59_RS19710	COG0424	maF-like protein
GPY59_RS19715	COG0564	pseudouridine synthase activity
GPY59_RS19720	COG1530	ribonuclease E activity
GPY59_RS19725	COG0659	secondary active sulfate transmembrane transporter activity
GPY59_RS19730	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GPY59_RS19735	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
GPY59_RS19745	COG0572	uridine kinase
GPY59_RS19755	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY59_RS19755	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY59_RS19765	COG2186	Transcriptional regulator
GPY59_RS19770	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GPY59_RS19775	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GPY59_RS19780	COG3012	SEC-C Motif Domain Protein
GPY59_RS19780	COG3318	Belongs to the UPF0149 family
GPY59_RS19785	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPY59_RS19790	COG3706	GGDEF domain
GPY59_RS19795	COG0366	Alpha amylase catalytic
GPY59_RS19800	COG1122	ATPase activity
GPY59_RS19805	COG4120	Belongs to the binding-protein-dependent transport system permease family
GPY59_RS19815	COG3092	negative regulation of chromosome organization
GPY59_RS19820	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GPY59_RS19825	COG0280	phosphate acetyltransferase
GPY59_RS19825	COG0857	belongs to the CobB CobQ family
GPY59_RS19835	COG0435	Glutathione S-transferase
GPY59_RS19845	COG0444	Belongs to the ABC transporter superfamily
GPY59_RS19850	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY59_RS19855	COG0601	transmembrane transport
GPY59_RS19865	COG0314	molybdopterin synthase activity
GPY59_RS19870	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GPY59_RS19875	COG0315	cyclic pyranopterin monophosphate synthase activity
GPY59_RS19880	COG0521	Mo-molybdopterin cofactor biosynthetic process
GPY59_RS19885	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GPY59_RS19890	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GPY59_RS19895	COG2198	Histidine kinase
GPY59_RS19900	COG2204	response regulator
GPY59_RS19905	COG0556	nucleotide-excision repair
GPY59_RS19915	COG1882	Formate acetyltransferase
GPY59_RS19920	COG4657	Part of a membrane complex involved in electron transport
GPY59_RS19925	COG2878	Part of a membrane complex involved in electron transport
GPY59_RS19930	COG4656	Part of a membrane complex involved in electron transport
GPY59_RS19935	COG4658	electron transport chain
GPY59_RS19940	COG4659	FMN binding
GPY59_RS19945	COG4660	Part of a membrane complex involved in electron transport
GPY59_RS19950	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GPY59_RS19955	COG0346	lactoylglutathione lyase activity
GPY59_RS19965	COG2885	chlorophyll binding
GPY59_RS19975	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GPY59_RS19980	COG2056	Na+-H+ antiporter family
GPY59_RS20060	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GPY59_RS20110	COG4695	Portal protein
GPY59_RS20205	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GPY59_RS20220	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GPY59_RS20245	COG2095	MarC family integral membrane protein
GPY59_RS20250	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY59_RS20255	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GPY59_RS20260	COG1757	Na H antiporter
GPY59_RS20275	COG3081	Nucleoid-associated protein
GPY59_RS20280	COG3082	Protein of unknown function (DUF1414)
GPY59_RS20285	COG3083	sulfuric ester hydrolase activity
GPY59_RS20295	COG0123	including yeast histone deacetylase and acetoin utilization protein
GPY59_RS20310	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GPY59_RS20315	COG0778	Nitroreductase
GPY59_RS20325	COG1902	pentaerythritol trinitrate reductase activity
GPY59_RS20325	COG0446	pyridine nucleotide-disulphide oxidoreductase
GPY59_RS20330	COG0616	signal peptide processing
GPY59_RS20335	COG0252	asparaginase activity
GPY59_RS20340	COG3139	Protein of unknown function (DUF1315)
GPY59_RS20350	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY59_RS20355	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPY59_RS20370	COG2226	methyltransferase
GPY59_RS20390	COG1785	Belongs to the alkaline phosphatase family
GPY59_RS20400	COG0346	lactoylglutathione lyase activity
GPY59_RS20405	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
GPY59_RS20410	COG0668	transmembrane transport
GPY59_RS20415	COG2983	Belongs to the UPF0260 family
GPY59_RS20420	COG2261	transglycosylase associated protein
GPY59_RS20430	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GPY59_RS20435	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GPY59_RS20440	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GPY59_RS20450	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GPY59_RS20455	COG2832	Protein of unknown function (DUF454)
GPY59_RS20465	COG0745	RESPONSE REGULATOR receiver
GPY59_RS20470	COG0583	DNA-binding transcription factor activity
GPY59_RS20475	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GPY59_RS20480	COG1286	toxin biosynthetic process
GPY59_RS20485	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
GPY59_RS20490	COG0285	dihydrofolate synthase activity
GPY59_RS20495	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GPY59_RS20500	COG0101	tRNA pseudouridine synthase activity
GPY59_RS20510	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GPY59_RS20515	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPY59_RS20520	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPY59_RS20525	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPY59_RS20525	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GPY59_RS20530	COG0431	NADPH-dependent FMN reductase
GPY59_RS20545	COG3101	peptidyl-lysine hydroxylation
GPY59_RS20555	COG2860	membrane
GPY59_RS20560	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GPY59_RS20565	COG2890	protein-(glutamine-N5) methyltransferase activity
GPY59_RS20570	COG2840	Smr protein MutS2
GPY59_RS20575	COG2062	phosphohistidine phosphatase, SixA
GPY59_RS20590	COG1024	Enoyl-CoA hydratase
GPY59_RS20590	COG1250	3-hydroxyacyl-CoA dehydrogenase
GPY59_RS20595	COG0183	Belongs to the thiolase family
GPY59_RS20615	COG2067	long-chain fatty acid transport protein
GPY59_RS20625	COG3088	subunit of a heme lyase
GPY59_RS20625	COG4235	cytochrome complex assembly
GPY59_RS20635	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GPY59_RS20640	COG1138	Cytochrome C-type biogenesis protein
GPY59_RS20645	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
GPY59_RS20650	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPY59_RS20655	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPY59_RS20660	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPY59_RS20665	COG4133	protoheme IX ABC transporter activity
GPY59_RS20675	COG0835	chemotaxis
GPY59_RS20685	COG1192	Involved in chromosome partitioning
GPY59_RS20690	COG2201	protein-glutamate methylesterase activity
GPY59_RS20695	COG0643	Histidine kinase
GPY59_RS20695	COG2198	Histidine kinase
GPY59_RS20700	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
GPY59_RS20715	COG0455	bacterial-type flagellum organization
GPY59_RS20735	COG1684	flagellar biosynthetic protein fliR
GPY59_RS20740	COG1987	bacterial-type flagellum assembly
GPY59_RS20795	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GPY59_RS20805	COG1677	Flagellar hook-basal body complex protein FliE
GPY59_RS20810	COG2204	response regulator
GPY59_RS20815	COG4191	Histidine kinase
GPY59_RS20820	COG2204	response regulator
GPY59_RS20825	COG1516	flagellar protein fliS
GPY59_RS20835	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GPY59_RS20840	COG1334	flagellar protein FlaG
GPY59_RS20845	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY59_RS20850	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY59_RS20860	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY59_RS20865	COG2837	iron assimilation
GPY59_RS20890	COG1393	Belongs to the ArsC family
GPY59_RS20895	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPY59_RS20915	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GPY59_RS20925	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GPY59_RS20940	COG4783	chaperone-mediated protein folding
GPY59_RS20945	COG1393	Belongs to the ArsC family
GPY59_RS20965	COG2233	PERMEase
GPY59_RS20970	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GPY59_RS20975	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GPY59_RS20980	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GPY59_RS20985	COG0121	glutamine amidotransferase
GPY59_RS20990	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GPY59_RS20995	COG1960	acyl-CoA dehydrogenase activity
GPY59_RS21025	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GPY59_RS21030	COG0328	RNA-DNA hybrid ribonuclease activity
GPY59_RS21035	COG2226	methyltransferase
GPY59_RS21040	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPY59_RS21045	COG1388	LysM domain
GPY59_RS21045	COG0741	lytic transglycosylase activity
GPY59_RS21055	COG3021	interspecies interaction between organisms
GPY59_RS21060	COG0347	Belongs to the P(II) protein family
GPY59_RS21075	COG0825	malonyl-CoA metabolic process
GPY59_RS21080	COG0587	DNA-directed DNA polymerase activity
GPY59_RS21090	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY59_RS21095	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY59_RS21105	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY59_RS21110	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
GPY59_RS21120	COG0750	zinc metalloprotease
GPY59_RS21125	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GPY59_RS21130	COG0575	Belongs to the CDS family
GPY59_RS21135	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GPY59_RS21140	COG0233	cytoplasmic translational termination
GPY59_RS21145	COG0528	UMP kinase activity
GPY59_RS21150	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GPY59_RS21155	COG0052	Belongs to the universal ribosomal protein uS2 family
GPY59_RS21160	COG0024	Methionine aminopeptidase
GPY59_RS21165	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GPY59_RS21175	COG0564	pseudouridine synthase activity
GPY59_RS21210	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GPY59_RS21215	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GPY59_RS21240	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPY59_RS21250	COG0254	rRNA binding
GPY59_RS21255	COG1720	tRNA m6t6A37 methyltransferase activity
GPY59_RS21260	COG0442	prolyl-tRNA aminoacylation
GPY59_RS21280	COG0733	neurotransmitter:sodium symporter activity
GPY59_RS21295	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY59_RS21300	COG0514	ATP-dependent DNA helicase (RecQ)
GPY59_RS21305	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GPY59_RS21315	COG3706	GGDEF domain
GPY59_RS21315	COG0745	RESPONSE REGULATOR receiver
GPY59_RS21325	COG1477	protein flavinylation
GPY59_RS21330	COG2871	sodium ion transport
GPY59_RS21335	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY59_RS21340	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY59_RS21345	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY59_RS21350	COG1805	sodium ion transport
GPY59_RS21355	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY59_RS21360	COG0271	Belongs to the BolA IbaG family
GPY59_RS21365	COG2813	Specifically methylates the guanine in position
GPY59_RS21370	COG3056	Lipoprotein
GPY59_RS21390	COG1595	DNA-templated transcription, initiation
GPY59_RS21410	COG3248	Nucleoside-binding outer membrane protein
GPY59_RS21415	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GPY59_RS21420	COG0693	protein deglycase activity
GPY59_RS21425	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GPY59_RS21430	COG3706	GGDEF domain
GPY59_RS21435	COG2166	iron-sulfur cluster assembly
GPY59_RS21440	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GPY59_RS21445	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
GPY59_RS21455	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GPY59_RS21455	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GPY59_RS21465	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GPY59_RS21470	COG1074	ATP-dependent DNA helicase activity
GPY59_RS21475	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GPY59_RS21495	COG3141	response to X-ray
GPY59_RS21510	COG2171	N-acyltransferase activity
GPY59_RS21515	COG0584	glycerophosphoryl diester phosphodiesterase
GPY59_RS21520	COG2271	Major facilitator Superfamily
GPY59_RS21530	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GPY59_RS21535	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GPY59_RS21540	COG1349	DNA-binding transcription factor activity
GPY59_RS21545	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GPY59_RS21550	COG0598	Magnesium transport protein CorA
GPY59_RS21570	COG1609	Transcriptional regulator
GPY59_RS21575	COG0583	DNA-binding transcription factor activity
GPY59_RS21615	COG1022	Amp-dependent synthetase and ligase
GPY59_RS21625	COG0583	DNA-binding transcription factor activity
GPY59_RS21630	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPY59_RS21635	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GPY59_RS21645	COG0560	Phosphoserine phosphatase
GPY59_RS21655	COG0813	purine-nucleoside phosphorylase activity
GPY59_RS21660	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GPY59_RS21665	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GPY59_RS21670	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GPY59_RS21675	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPY59_RS21680	COG0084	hydrolase, TatD family'
GPY59_RS21710	COG3153	acetyltransferase
GPY59_RS21735	COG0534	Mate efflux family protein
GPY59_RS21750	COG1185	polyribonucleotide nucleotidyltransferase activity
GPY59_RS21755	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GPY59_RS21760	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GPY59_RS21765	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GPY59_RS21770	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GPY59_RS21775	COG0195	Participates in both transcription termination and antitermination
GPY59_RS21780	COG0779	Required for maturation of 30S ribosomal subunits
GPY59_RS21795	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GPY59_RS21805	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPY59_RS21810	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GPY59_RS21815	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GPY59_RS21820	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GPY59_RS21825	COG1534	Rna-binding protein
GPY59_RS21830	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY59_RS21835	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPY59_RS21840	COG2027	D-alanyl-D-alanine carboxypeptidase
GPY59_RS21850	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GPY59_RS21855	COG0739	heme binding
GPY59_RS21880	COG0628	permease
GPY59_RS21895	COG0747	negative chemotaxis
GPY59_RS21905	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY59_RS21910	COG0444	Belongs to the ABC transporter superfamily
GPY59_RS21915	COG4608	Belongs to the ABC transporter superfamily
GPY59_RS21925	COG2971	BadF BadG BcrA BcrD
GPY59_RS21940	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPY59_RS21945	COG3842	ATPase activity
GPY59_RS21955	COG1840	ABC-type Fe3 transport system, periplasmic component
GPY59_RS21960	COG0004	ammonium transporteR
GPY59_RS21970	COG3112	Uncharacterised protein family (UPF0231)
GPY59_RS21975	COG1049	propionate catabolic process, 2-methylcitrate cycle
GPY59_RS21980	COG1752	Esterase of the alpha-beta hydrolase superfamily
GPY59_RS21985	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GPY59_RS21990	COG1643	Atp-dependent helicase
GPY59_RS21995	COG1489	DNA binding
GPY59_RS22000	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GPY59_RS22005	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPY59_RS22015	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GPY59_RS22020	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GPY59_RS22025	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GPY59_RS22030	COG1560	Kdo2-lipid A biosynthetic process
GPY59_RS22035	COG0842	Transport permease protein
GPY59_RS22040	COG1131	(ABC) transporter
GPY59_RS22045	COG0659	secondary active sulfate transmembrane transporter activity
GPY59_RS22050	COG0288	reversible hydration of carbon dioxide
GPY59_RS22065	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY59_RS22070	COG0508	dehydrogenase complex catalyzes the overall conversion of
GPY59_RS22075	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GPY59_RS22080	COG2186	Transcriptional regulator
GPY59_RS22090	COG0157	Belongs to the NadC ModD family
GPY59_RS22100	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY59_RS22105	COG1459	type II secretion system
GPY59_RS22115	COG0237	dephospho-CoA kinase activity
GPY59_RS22120	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
GPY59_RS22125	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GPY59_RS22140	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GPY59_RS22145	COG0228	four-way junction DNA binding
GPY59_RS22150	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GPY59_RS22155	COG4137	Cytochrome C assembly protein
GPY59_RS22160	COG4536	flavin adenine dinucleotide binding
GPY59_RS22165	COG1854	S-ribosylhomocysteine lyase activity
GPY59_RS22180	COG0612	Peptidase, M16
GPY59_RS22185	COG1238	metal cluster binding
GPY59_RS22195	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GPY59_RS22200	COG5016	pyruvate
GPY59_RS22200	COG0511	ligase activity, forming carbon-carbon bonds
GPY59_RS22265	COG0527	aspartate kinase activity
GPY59_RS22270	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GPY59_RS22275	COG2137	regulation of response to DNA damage stimulus
GPY59_RS22285	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GPY59_RS22290	COG1546	Belongs to the CinA family
GPY59_RS22295	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GPY59_RS22300	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPY59_RS22310	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GPY59_RS22315	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GPY59_RS22325	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GPY59_RS22330	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GPY59_RS22335	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GPY59_RS22340	COG0148	phosphopyruvate hydratase activity
GPY59_RS22345	COG0504	CTP synthase activity
GPY59_RS22350	COG3956	TIGRFAM MazG family protein
GPY59_RS22355	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GPY59_RS22365	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPY59_RS22380	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GPY59_RS22385	COG1381	Involved in DNA repair and RecF pathway recombination
GPY59_RS22390	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GPY59_RS22400	COG0681	Belongs to the peptidase S26 family
GPY59_RS22405	COG0481	GTPase activity
GPY59_RS22410	COG3086	response to oxidative stress
GPY59_RS22425	COG1595	DNA-templated transcription, initiation
GPY59_RS22435	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GPY59_RS22440	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GPY59_RS22460	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPY59_RS22465	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPY59_RS22470	COG3079	Belongs to the UPF0149 family
GPY59_RS22480	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
GPY59_RS22490	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GPY59_RS22495	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GPY59_RS22500	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPY59_RS22510	COG0583	DNA-binding transcription factor activity
GPY59_RS22525	COG0668	transmembrane transport
GPY59_RS22530	COG0191	fructose-bisphosphate aldolase activity
GPY59_RS22545	COG4771	TonB-dependent receptor
GPY59_RS22550	COG0583	DNA-binding transcription factor activity
GPY59_RS22555	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GPY59_RS22565	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GPY59_RS22580	COG2356	endonuclease I
GPY59_RS22585	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GPY59_RS22590	COG0189	ligase activity
GPY59_RS22595	COG1678	Uncharacterized ACR, COG1678
GPY59_RS22600	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GPY59_RS22615	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GPY59_RS22620	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GPY59_RS22625	COG0762	integral membrane protein
GPY59_RS22630	COG1872	DUF167
GPY59_RS22640	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GPY59_RS22645	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GPY59_RS22650	COG2066	Belongs to the glutaminase family
GPY59_RS22660	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GPY59_RS22670	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
GPY59_RS22715	COG0840	transmembrane signaling receptor activity
GPY59_RS22790	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GPY59_RS22800	COG3394	polysaccharide catabolic process
GPY59_RS22805	COG1486	melibiose metabolic process
GPY59_RS22810	COG1447	Phosphotransferase system cellobiose-specific component IIA
GPY59_RS22815	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GPY59_RS22825	COG0726	polysaccharide deacetylase
GPY59_RS22870	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GPY59_RS22935	COG1028	Short-chain dehydrogenase reductase Sdr
GPY59_RS22940	COG4325	translation initiation factor activity
GPY59_RS22950	COG0795	lipopolysaccharide-transporting ATPase activity
GPY59_RS22955	COG0795	lipopolysaccharide-transporting ATPase activity
GPY59_RS22960	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GPY59_RS22965	COG2927	DNA polymerase III (CHI subunit)
GPY59_RS22970	COG0525	valine-tRNA ligase activity
GPY59_RS22980	COG0456	acetyltransferase
GPY59_RS23010	COG0540	Belongs to the ATCase OTCase family
GPY59_RS23015	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
GPY59_RS23020	COG0251	oxidation-reduction process
GPY59_RS23025	COG0204	Acyl-transferase
GPY59_RS23030	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GPY59_RS23035	COG5007	Belongs to the BolA IbaG family
GPY59_RS23045	COG2854	intermembrane phospholipid transfer
GPY59_RS23050	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GPY59_RS23055	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GPY59_RS23060	COG1127	ABC transporter
GPY59_RS23070	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GPY59_RS23070	COG0517	IMP dehydrogenase activity
GPY59_RS23080	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GPY59_RS23085	COG1137	ATPase activity
GPY59_RS23095	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GPY59_RS23100	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY59_RS23105	COG1660	Displays ATPase and GTPase activities
GPY59_RS23110	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY59_RS23115	COG2239	Acts as a magnesium transporter
GPY59_RS23120	COG0312	modulator of DNA gyrase
GPY59_RS23125	COG3028	Belongs to the UPF0307 family
GPY59_RS23130	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GPY59_RS23135	COG0564	pseudouridine synthase activity
GPY59_RS23145	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GPY59_RS23150	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GPY59_RS23155	COG0312	modulator of DNA gyrase
GPY59_RS23160	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GPY59_RS23165	COG3164	Protein of unknown function
GPY59_RS23170	COG1530	ribonuclease E activity
GPY59_RS23175	COG0424	maF-like protein
GPY59_RS23180	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GPY59_RS23185	COG1792	Involved in formation and maintenance of cell shape
GPY59_RS23190	COG1077	Cell shape determining protein MreB Mrl
GPY59_RS23235	COG1459	type II secretion system
GPY59_RS23240	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY59_RS23250	COG3267	Type II secretory pathway component ExeA
GPY59_RS23250	COG3409	Peptidoglycan-binding domain 1 protein
GPY59_RS23255	COG1450	Type ii and iii secretion system protein
GPY59_RS23275	COG2199	diguanylate cyclase activity
GPY59_RS23275	COG2200	EAL domain
GPY59_RS23280	COG0629	single-stranded DNA binding
GPY59_RS23295	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GPY59_RS23305	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GPY59_RS23310	COG0527	aspartate kinase activity
GPY59_RS23315	COG1410	methionine synthase
GPY59_RS23315	COG0646	methionine synthase
GPY59_RS23370	COG0175	sulfate reduction
GPY59_RS23375	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GPY59_RS23380	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GPY59_RS23400	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPY59_RS23405	COG0735	belongs to the Fur family
GPY59_RS23415	COG0166	Belongs to the GPI family
GPY59_RS23420	COG0432	Pfam Uncharacterised protein family UPF0047
GPY59_RS23425	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPY59_RS23430	COG0305	Participates in initiation and elongation during chromosome replication
GPY59_RS23450	COG2965	DNA replication, synthesis of RNA primer
GPY59_RS23455	COG0360	Binds together with S18 to 16S ribosomal RNA
GPY59_RS23460	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GPY59_RS23465	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GPY59_RS23475	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GPY59_RS23480	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GPY59_RS23510	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GPY59_RS23520	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPY59_RS23520	COG0678	peroxiredoxin activity
GPY59_RS23525	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY59_RS23535	COG0165	Argininosuccinate lyase
GPY59_RS23535	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GPY59_RS23540	COG0137	argininosuccinate synthase activity
GPY59_RS23550	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GPY59_RS23560	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GPY59_RS23570	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GPY59_RS23575	COG0527	aspartate kinase activity
GPY59_RS23575	COG0460	homoserine dehydrogenase
GPY59_RS23580	COG0626	cystathionine gamma-synthase activity
GPY59_RS23590	COG0281	malic enzyme
GPY59_RS23600	COG2906	2 iron, 2 sulfur cluster binding
GPY59_RS23605	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GPY59_RS23610	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPY59_RS23630	COG2923	Belongs to the DsrF TusC family
GPY59_RS23635	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GPY59_RS23640	COG2964	Protein conserved in bacteria
GPY59_RS23645	COG0545	Peptidyl-prolyl cis-trans isomerase
GPY59_RS23660	COG1446	asparaginase
GPY59_RS23670	COG1047	Peptidyl-prolyl cis-trans
GPY59_RS23685	COG2249	NAD(P)H dehydrogenase (quinone) activity
GPY59_RS23690	COG0488	(ABC) transporter
GPY59_RS23700	COG0429	hydrolase of the alpha beta-hydrolase fold
GPY59_RS23710	COG3954	Phosphoribulokinase
GPY59_RS23715	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY59_RS23735	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GPY59_RS23740	COG0512	Glutamine amidotransferase of anthranilate synthase
GPY59_RS23755	COG0180	Tryptophanyl-tRNA synthetase
GPY59_RS23760	COG0546	phosphoglycolate phosphatase activity
GPY59_RS23765	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPY59_RS23770	COG0557	exoribonuclease II activity
GPY59_RS23775	COG1959	2 iron, 2 sulfur cluster binding
GPY59_RS23780	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPY59_RS23780	COG1017	nitric oxide dioxygenase activity
GPY59_RS23785	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
GPY59_RS23795	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GPY59_RS23800	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
GPY59_RS23805	COG0330	HflC and HflK could
GPY59_RS23810	COG0330	HflC and HflK could
GPY59_RS23815	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GPY59_RS23825	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GPY59_RS23830	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GPY59_RS23840	COG0802	atpase or kinase
GPY59_RS23845	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GPY59_RS23910	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GPY59_RS23915	COG1162	GTPase activity
GPY59_RS23920	COG0688	phosphatidylethanolamine metabolic process
GPY59_RS23925	COG0471	metal ion transport
GPY59_RS23935	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GPY59_RS23940	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY59_RS23945	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GPY59_RS23950	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GPY59_RS23955	COG1045	serine acetyltransferase
GPY59_RS23960	COG4942	peptidase
GPY59_RS23980	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
GPY59_RS23985	COG1053	succinate dehydrogenase
GPY59_RS23990	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GPY59_RS23995	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GPY59_RS24015	COG1509	lysine 2,3-aminomutase activity
GPY59_RS24020	COG1285	pathogenesis
GPY59_RS24030	COG0459	protein refolding
GPY59_RS24035	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GPY59_RS24040	COG0534	Mate efflux family protein
GPY59_RS24045	COG0205	6-phosphofructokinase activity
GPY59_RS24055	COG3678	ATP-independent chaperone mediated protein folding
GPY59_RS24060	COG0745	RESPONSE REGULATOR receiver
GPY59_RS24065	COG2205	protein histidine kinase activity
GPY59_RS24075	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GPY59_RS24080	COG3030	protein affecting phage T7 exclusion by the F plasmid
GPY59_RS24085	COG1027	Aspartate ammonia-lyase
GPY59_RS24090	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GPY59_RS24095	COG4232	protein-disulfide reductase activity
GPY59_RS24105	COG3263	regulation of cellular component size
GPY59_RS24115	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPY59_RS24140	COG2814	Major facilitator Superfamily
GPY59_RS24155	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPY59_RS24160	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GPY59_RS24165	COG0511	ligase activity, forming carbon-carbon bonds
GPY59_RS24170	COG0439	Biotin carboxylase
GPY59_RS24175	COG2264	protein methyltransferase activity
GPY59_RS24180	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPY59_RS24185	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GPY59_RS24195	COG0488	(ABC) transporter
GPY59_RS24250	COG1982	Orn Lys Arg decarboxylase major
GPY59_RS24255	COG0531	amino acid
GPY59_RS24265	COG3710	Transcriptional regulator
GPY59_RS24285	COG0151	Belongs to the GarS family
GPY59_RS24300	COG1253	flavin adenine dinucleotide binding
GPY59_RS24305	COG3068	Protein conserved in bacteria
GPY59_RS24315	COG1573	uracil-dna glycosylase
GPY59_RS24320	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GPY59_RS24325	COG2816	NAD+ diphosphatase activity
GPY59_RS24330	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
GPY59_RS24335	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GPY59_RS24340	COG0085	RNA polymerase activity
GPY59_RS24345	COG0222	ribosome binding
GPY59_RS24350	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GPY59_RS24365	COG0250	Participates in transcription elongation, termination and antitermination
GPY59_RS24370	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GPY59_RS24380	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GPY59_RS24410	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
GPY59_RS24410	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
GPY59_RS24415	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GPY59_RS24425	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GPY59_RS24505	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPY59_RS24525	COG1192	Involved in chromosome partitioning
GPY59_RS24610	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GPY59_RS24700	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPY59_RS24725	COG5001	Diguanylate cyclase
GPY59_RS24760	COG0714	Associated with various cellular activities
GPY59_RS24770	COG0629	single-stranded DNA binding
GPY59_RS24815	COG0633	Ferredoxin
GPY59_RS24975	COG4974	Belongs to the 'phage' integrase family
GPY59_RS25120	COG0616	signal peptide processing
GPY59_RS25165	COG0776	regulation of translation
GPY59_RS25220	COG3316	Transposase and inactivated derivatives
GPY59_RS25230	COG3316	Transposase and inactivated derivatives
GPY59_RS25270	COG3316	Transposase and inactivated derivatives
GPY59_RS25275	COG3316	Transposase and inactivated derivatives
GPY59_RS25330	COG1192	Involved in chromosome partitioning
GPY59_RS25335	COG1475	DNA binding
GPY59_RS25445	COG1462	curli production assembly transport component CsgG
GPY59_RS25565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY59_RS25585	COG0456	acetyltransferase
GPY59_RS25590	COG1403	HNH endonuclease
GPY59_RS25635	COG0745	RESPONSE REGULATOR receiver
GPY59_RS25635	COG3706	GGDEF domain
GPY59_RS25900	COG1028	Short-chain dehydrogenase reductase Sdr
GPY59_RS25985	COG0776	regulation of translation
GPY59_RS26045	COG0629	single-stranded DNA binding