locus-tag	class	description
GPY47_RS00010	COG2203	Gaf domain
GPY47_RS00010	COG3706	GGDEF domain
GPY47_RS00010	COG4251	negative regulation of phosphorylation
GPY47_RS00010	COG5001	Diguanylate cyclase
GPY47_RS00020	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GPY47_RS00025	COG4149	molybdate abc transporter
GPY47_RS00030	COG0725	ABC transporter, periplasmic molybdate-binding protein
GPY47_RS00040	COG3111	PFAM Bacterial OB fold (BOF) protein
GPY47_RS00050	COG4067	protein conserved in archaea
GPY47_RS00050	COG0189	ligase activity
GPY47_RS00060	COG2207	Transcriptional regulator
GPY47_RS00065	COG0534	Mate efflux family protein
GPY47_RS00070	COG0602	queuosine metabolic process
GPY47_RS00075	COG1328	CTP reductase activity
GPY47_RS00190	COG4735	regulation of single-species biofilm formation
GPY47_RS00245	COG3706	GGDEF domain
GPY47_RS00290	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GPY47_RS00295	COG0446	pyridine nucleotide-disulphide oxidoreductase
GPY47_RS00300	COG1794	racemase activity, acting on amino acids and derivatives
GPY47_RS00305	COG0384	phenazine biosynthesis protein PhzF
GPY47_RS00320	COG0243	molybdopterin cofactor binding
GPY47_RS00330	COG0583	DNA-binding transcription factor activity
GPY47_RS00335	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GPY47_RS00345	COG2197	response regulator
GPY47_RS00350	COG3851	Histidine kinase
GPY47_RS00355	COG2271	Major facilitator Superfamily
GPY47_RS00380	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GPY47_RS00385	COG3118	belongs to the thioredoxin family
GPY47_RS00390	COG2814	Major facilitator Superfamily
GPY47_RS00420	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GPY47_RS00440	COG2116	formate transmembrane transporter activity
GPY47_RS00445	COG2146	nitrite reductase [NAD(P)H] activity
GPY47_RS00450	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GPY47_RS00455	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY47_RS00475	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GPY47_RS00525	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPY47_RS00540	COG0277	FAD linked oxidase domain protein
GPY47_RS00545	COG0583	DNA-binding transcription factor activity
GPY47_RS00560	COG2425	protein containing a von Willebrand factor type A (vWA) domain
GPY47_RS00575	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
GPY47_RS00585	COG1288	antiporter activity
GPY47_RS00595	COG3040	lipid binding
GPY47_RS00605	COG0419	ATPase involved in DNA repair
GPY47_RS00610	COG0420	3'-5' exonuclease activity
GPY47_RS00625	COG3501	Rhs element vgr protein
GPY47_RS00680	COG0631	protein serine/threonine phosphatase activity
GPY47_RS00715	COG2815	serine threonine protein kinase
GPY47_RS00715	COG0515	serine threonine protein kinase
GPY47_RS00765	COG2146	nitrite reductase [NAD(P)H] activity
GPY47_RS00765	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GPY47_RS00770	COG1116	anion transmembrane transporter activity
GPY47_RS00775	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GPY47_RS00780	COG1116	anion transmembrane transporter activity
GPY47_RS00780	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GPY47_RS00790	COG3707	response regulator
GPY47_RS00810	COG0243	molybdopterin cofactor binding
GPY47_RS00820	COG0814	amino acid
GPY47_RS00830	COG3706	GGDEF domain
GPY47_RS00885	COG2847	Copper chaperone PCu(A)C
GPY47_RS00890	COG1028	Short-chain dehydrogenase reductase Sdr
GPY47_RS00895	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GPY47_RS00905	COG0800	Aldolase
GPY47_RS00910	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY47_RS00915	COG1917	Cupin 2, conserved barrel domain protein
GPY47_RS00960	COG2186	Transcriptional regulator
GPY47_RS00965	COG2186	Transcriptional regulator
GPY47_RS00970	COG0517	IMP dehydrogenase activity
GPY47_RS00975	COG2176	DNA-directed DNA polymerase activity
GPY47_RS00980	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPY47_RS01045	COG4160	amino acid transport
GPY47_RS01050	COG4215	(ABC) transporter
GPY47_RS01055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY47_RS01060	COG1126	abc transporter atp-binding protein
GPY47_RS01090	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPY47_RS01100	COG1012	belongs to the aldehyde dehydrogenase family
GPY47_RS01115	COG0446	pyridine nucleotide-disulphide oxidoreductase
GPY47_RS01115	COG1902	pentaerythritol trinitrate reductase activity
GPY47_RS01120	COG0109	protoheme IX farnesyltransferase activity
GPY47_RS01125	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GPY47_RS01130	COG1845	cytochrome c oxidase, subunit III
GPY47_RS01135	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GPY47_RS01140	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GPY47_RS01145	COG1028	Short-chain dehydrogenase reductase Sdr
GPY47_RS01155	COG1024	Enoyl-CoA hydratase
GPY47_RS01160	COG1024	Enoyl-CoA hydratase
GPY47_RS01175	COG0183	Belongs to the thiolase family
GPY47_RS01185	COG1960	acyl-CoA dehydrogenase activity
GPY47_RS01190	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GPY47_RS01195	COG1024	Enoyl-CoA hydratase
GPY47_RS01220	COG2095	MarC family integral membrane protein
GPY47_RS01225	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GPY47_RS01235	COG0523	cobalamin synthesis protein
GPY47_RS01240	COG0739	heme binding
GPY47_RS01245	COG2988	succinylglutamate desuccinylase activity
GPY47_RS01250	COG0523	cobalamin synthesis protein
GPY47_RS01260	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GPY47_RS01265	COG0735	belongs to the Fur family
GPY47_RS01280	COG0730	response to heat
GPY47_RS01295	COG1073	alpha beta
GPY47_RS01300	COG1073	alpha beta
GPY47_RS01310	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GPY47_RS01325	COG0513	Belongs to the DEAD box helicase family
GPY47_RS01330	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
GPY47_RS01345	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GPY47_RS01365	COG1119	ATPase activity
GPY47_RS01370	COG2200	EAL domain
GPY47_RS01390	COG0513	Belongs to the DEAD box helicase family
GPY47_RS01395	COG0523	cobalamin synthesis protein
GPY47_RS01405	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
GPY47_RS01415	COG1278	Cold shock
GPY47_RS01425	COG0133	tryptophan synthase activity
GPY47_RS01435	COG4628	conserved protein (DUF2132)
GPY47_RS01440	COG0513	Belongs to the DEAD box helicase family
GPY47_RS01445	COG1074	ATP-dependent DNA helicase activity
GPY47_RS01455	COG3530	Putative quorum-sensing-regulated virulence factor
GPY47_RS01480	COG3186	Phenylalanine-4-hydroxylase
GPY47_RS01485	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPY47_RS01490	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPY47_RS01510	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
GPY47_RS01515	COG1454	alcohol dehydrogenase
GPY47_RS01520	COG2133	pyrroloquinoline quinone binding
GPY47_RS01530	COG0783	Belongs to the Dps family
GPY47_RS01560	COG2205	protein histidine kinase activity
GPY47_RS01560	COG0784	Response regulator, receiver
GPY47_RS01565	COG1538	Outer membrane efflux protein
GPY47_RS01575	COG1132	(ABC) transporter
GPY47_RS01590	COG2199	diguanylate cyclase activity
GPY47_RS01595	COG3036	rescue of stalled ribosome
GPY47_RS01600	COG1278	Cold shock
GPY47_RS01630	COG0545	Peptidyl-prolyl cis-trans isomerase
GPY47_RS01635	COG0109	protoheme IX farnesyltransferase activity
GPY47_RS01640	COG1612	heme a metabolic process
GPY47_RS01660	COG1845	cytochrome c oxidase, subunit III
GPY47_RS01665	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
GPY47_RS01675	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GPY47_RS01680	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPY47_RS01690	COG1280	lysine exporter protein (LysE YggA)
GPY47_RS01710	COG0179	Fumarylacetoacetate (FAA) hydrolase
GPY47_RS01725	COG0697	spore germination
GPY47_RS01745	COG2814	Major facilitator Superfamily
GPY47_RS01750	COG0583	DNA-binding transcription factor activity
GPY47_RS01755	COG5001	Diguanylate cyclase
GPY47_RS01760	COG0739	heme binding
GPY47_RS01800	COG0814	amino acid
GPY47_RS01825	COG4989	oxidoreductase activity
GPY47_RS01850	COG1733	regulation of RNA biosynthetic process
GPY47_RS01865	COG0798	PFAM Bile acid sodium symporter
GPY47_RS01875	COG1881	PFAM PEBP family protein
GPY47_RS01890	COG1131	(ABC) transporter
GPY47_RS01895	COG0842	Transport permease protein
GPY47_RS01905	COG3383	formate dehydrogenase (NAD+) activity
GPY47_RS01925	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY47_RS01950	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY47_RS01960	COG2067	long-chain fatty acid transport protein
GPY47_RS01970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY47_RS01980	COG1505	serine-type exopeptidase activity
GPY47_RS01985	COG0488	(ABC) transporter
GPY47_RS01990	COG0589	response to stress
GPY47_RS01995	COG2249	NAD(P)H dehydrogenase (quinone) activity
GPY47_RS02015	COG0366	Alpha amylase catalytic
GPY47_RS02020	COG0789	Transcriptional regulator
GPY47_RS02035	COG4934	collagen metabolic process
GPY47_RS02045	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GPY47_RS02050	COG0583	DNA-binding transcription factor activity
GPY47_RS02070	COG2610	gluconate transmembrane transporter activity
GPY47_RS02075	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GPY47_RS02080	COG3622	Belongs to the hyi family
GPY47_RS02085	COG0235	Class ii aldolase
GPY47_RS02090	COG3395	kinase activity
GPY47_RS02095	COG2084	Dehydrogenase
GPY47_RS02100	COG1349	DNA-binding transcription factor activity
GPY47_RS02110	COG0747	negative chemotaxis
GPY47_RS02115	COG4608	Belongs to the ABC transporter superfamily
GPY47_RS02125	COG0534	Mate efflux family protein
GPY47_RS02230	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPY47_RS02235	COG0784	Response regulator, receiver
GPY47_RS02235	COG0835	chemotaxis
GPY47_RS02245	COG0748	coenzyme F420 binding
GPY47_RS02250	COG3721	Heme iron utilization protein
GPY47_RS02260	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GPY47_RS02265	COG0811	peptide transport
GPY47_RS02270	COG0848	biopolymer transport protein
GPY47_RS02280	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY47_RS02285	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GPY47_RS02325	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GPY47_RS02335	COG3217	Mosc domain protein beta barrel domain protein
GPY47_RS02335	COG0633	Ferredoxin
GPY47_RS02335	COG3217	Mosc domain protein beta barrel domain protein
GPY47_RS02335	COG0633	Ferredoxin
GPY47_RS02340	COG0401	homolog of Blt101
GPY47_RS02350	COG0418	dihydroorotase activity
GPY47_RS02355	COG2354	Protein conserved in bacteria
GPY47_RS02385	COG3833	ABC-type maltose transport systems, permease component
GPY47_RS02390	COG1175	transmembrane transport
GPY47_RS02400	COG3842	ATPase activity
GPY47_RS02405	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GPY47_RS02420	COG3206	protein involved in exopolysaccharide biosynthesis
GPY47_RS02420	COG0489	protein tyrosine kinase activity
GPY47_RS02465	COG1309	transcriptional regulator
GPY47_RS02470	COG2130	NADP-dependent
GPY47_RS02480	COG0753	catalase activity
GPY47_RS02485	COG2084	Dehydrogenase
GPY47_RS02515	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY47_RS02520	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
GPY47_RS02525	COG0583	DNA-binding transcription factor activity
GPY47_RS02530	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY47_RS02535	COG0569	domain protein
GPY47_RS02550	COG1132	(ABC) transporter
GPY47_RS02555	COG4774	siderophore transport
GPY47_RS02560	COG1120	ATPase activity
GPY47_RS02565	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GPY47_RS02600	COG2197	response regulator
GPY47_RS02615	COG0714	Associated with various cellular activities
GPY47_RS02635	COG2304	oxidoreductase activity
GPY47_RS02650	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GPY47_RS02655	COG0581	inorganic phosphate transmembrane transporter activity
GPY47_RS02660	COG0573	inorganic phosphate transmembrane transporter activity
GPY47_RS02665	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GPY47_RS02690	COG4771	TonB-dependent receptor
GPY47_RS02695	COG1770	oligopeptidase
GPY47_RS02700	COG0513	Belongs to the DEAD box helicase family
GPY47_RS02710	COG1388	LysM domain
GPY47_RS02710	COG1376	ErfK ybiS ycfS ynhG family protein
GPY47_RS02715	COG0415	Belongs to the DNA photolyase family
GPY47_RS02720	COG0789	Transcriptional regulator
GPY47_RS02725	COG3272	Protein of unknown function (DUF1722)
GPY47_RS02735	COG0813	purine-nucleoside phosphorylase activity
GPY47_RS02750	COG3706	GGDEF domain
GPY47_RS02760	COG1566	PFAM secretion protein HlyD family protein
GPY47_RS02765	COG4720	Psort location CytoplasmicMembrane, score
GPY47_RS02770	COG1122	ATPase activity
GPY47_RS02790	COG0348	domain, Protein
GPY47_RS02795	COG0437	4 iron, 4 sulfur cluster binding
GPY47_RS02800	COG1247	-acetyltransferase
GPY47_RS02820	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPY47_RS02830	COG1067	ATP-dependent peptidase activity
GPY47_RS02840	COG4172	Belongs to the ABC transporter superfamily
GPY47_RS02845	COG1505	serine-type exopeptidase activity
GPY47_RS02850	COG0583	DNA-binding transcription factor activity
GPY47_RS02855	COG1620	l-lactate permease
GPY47_RS02860	COG1304	FMN binding
GPY47_RS02870	COG0668	transmembrane transport
GPY47_RS02905	COG1063	alcohol dehydrogenase
GPY47_RS02910	COG0156	8-amino-7-oxononanoate synthase activity
GPY47_RS02915	COG3300	MHYT domain
GPY47_RS02915	COG5001	Diguanylate cyclase
GPY47_RS02940	COG0745	RESPONSE REGULATOR receiver
GPY47_RS02965	COG0346	lactoylglutathione lyase activity
GPY47_RS03025	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GPY47_RS03040	COG2204	response regulator
GPY47_RS03065	COG1987	bacterial-type flagellum assembly
GPY47_RS03075	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GPY47_RS03090	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY47_RS03100	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GPY47_RS03105	COG1516	flagellar protein fliS
GPY47_RS03120	COG1580	Controls the rotational direction of flagella during chemotaxis
GPY47_RS03125	COG1191	sigma factor activity
GPY47_RS03130	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GPY47_RS03135	COG1360	Flagellar Motor Protein
GPY47_RS03175	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GPY47_RS03180	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GPY47_RS03200	COG0745	RESPONSE REGULATOR receiver
GPY47_RS03210	COG0454	-acetyltransferase
GPY47_RS03220	COG2814	Major facilitator Superfamily
GPY47_RS03265	COG0628	permease
GPY47_RS03270	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GPY47_RS03290	COG4628	conserved protein (DUF2132)
GPY47_RS03295	COG0583	DNA-binding transcription factor activity
GPY47_RS03320	COG1686	Belongs to the peptidase S11 family
GPY47_RS03340	COG0415	Belongs to the DNA photolyase family
GPY47_RS03345	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
GPY47_RS03350	COG3397	chitin binding
GPY47_RS03355	COG4667	esterase of the alpha-beta hydrolase superfamily
GPY47_RS03360	COG2095	MarC family integral membrane protein
GPY47_RS03375	COG1596	polysaccharide export
GPY47_RS03380	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GPY47_RS03400	COG0583	DNA-binding transcription factor activity
GPY47_RS03410	COG1301	dicarboxylic acid transport
GPY47_RS03425	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPY47_RS03430	COG0700	Nucleoside recognition
GPY47_RS03435	COG3366	ferrous iron transmembrane transporter activity
GPY47_RS03450	COG0366	Alpha amylase catalytic
GPY47_RS03455	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GPY47_RS03460	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GPY47_RS03465	COG1640	4-alpha-glucanotransferase
GPY47_RS03470	COG0058	SHG alpha-glucan phosphorylase activity
GPY47_RS03475	COG2909	trisaccharide binding
GPY47_RS03490	COG1999	signal sequence binding
GPY47_RS03495	COG1263	PTS System
GPY47_RS03495	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY47_RS03500	COG1162	GTPase activity
GPY47_RS03505	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GPY47_RS03510	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
GPY47_RS03530	COG2356	endonuclease I
GPY47_RS03550	COG4580	involved in the transport of maltose and maltodextrins
GPY47_RS03560	COG1760	l-serine dehydratase
GPY47_RS03610	COG1609	Transcriptional regulator
GPY47_RS03615	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GPY47_RS03640	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPY47_RS03645	COG1609	Transcriptional regulator
GPY47_RS03655	COG2814	Major facilitator Superfamily
GPY47_RS03670	COG0739	heme binding
GPY47_RS03680	COG0612	Peptidase, M16
GPY47_RS03685	COG0840	transmembrane signaling receptor activity
GPY47_RS03690	COG1120	ATPase activity
GPY47_RS03695	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY47_RS03705	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GPY47_RS03710	COG4772	TonB-dependent receptor
GPY47_RS03730	COG2814	Major facilitator Superfamily
GPY47_RS03735	COG4264	IucA IucC family
GPY47_RS03740	COG0019	diaminopimelate decarboxylase activity
GPY47_RS03760	COG1136	(ABC) transporter
GPY47_RS03810	COG1764	response to oxidative stress
GPY47_RS03815	COG1846	Transcriptional regulator
GPY47_RS03820	COG0450	alkyl hydroperoxide reductase
GPY47_RS03825	COG3634	alkyl hydroperoxide reductase activity
GPY47_RS03875	COG2258	MOSC domain
GPY47_RS03880	COG0513	Belongs to the DEAD box helicase family
GPY47_RS03890	COG1132	(ABC) transporter
GPY47_RS03930	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPY47_RS03955	COG0259	pyridoxamine-phosphate oxidase activity
GPY47_RS04000	COG4166	transmembrane transport
GPY47_RS04020	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GPY47_RS04025	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY47_RS04025	COG1263	PTS System
GPY47_RS04030	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPY47_RS04035	COG3340	Belongs to the peptidase S51 family
GPY47_RS04055	COG1444	tRNA N-acetyltransferase activity
GPY47_RS04080	COG4608	Belongs to the ABC transporter superfamily
GPY47_RS04085	COG0444	Belongs to the ABC transporter superfamily
GPY47_RS04095	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GPY47_RS04095	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
GPY47_RS04120	COG0772	Belongs to the SEDS family
GPY47_RS04130	COG1136	(ABC) transporter
GPY47_RS04150	COG3275	phosphorelay sensor kinase activity
GPY47_RS04155	COG3279	Response regulator of the LytR AlgR family
GPY47_RS04160	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GPY47_RS04180	COG0786	glutamate:sodium symporter activity
GPY47_RS04190	COG1131	(ABC) transporter
GPY47_RS04195	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY47_RS04200	COG0786	glutamate:sodium symporter activity
GPY47_RS04210	COG0363	glucosamine-6-phosphate deaminase activity
GPY47_RS04230	COG1741	Belongs to the pirin family
GPY47_RS04235	COG2259	Doxx family
GPY47_RS04245	COG2169	Transcriptional regulator
GPY47_RS04245	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GPY47_RS04250	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GPY47_RS04260	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GPY47_RS04285	COG0596	Alpha beta hydrolase
GPY47_RS04300	COG3123	guanosine phosphorylase activity
GPY47_RS04310	COG5001	Diguanylate cyclase
GPY47_RS04315	COG0534	Mate efflux family protein
GPY47_RS04320	COG0564	pseudouridine synthase activity
GPY47_RS04335	COG0583	DNA-binding transcription factor activity
GPY47_RS04340	COG0561	phosphatase activity
GPY47_RS04350	COG2199	diguanylate cyclase activity
GPY47_RS04365	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
GPY47_RS04370	COG2162	N-hydroxyarylamine O-acetyltransferase activity
GPY47_RS04375	COG0583	DNA-binding transcription factor activity
GPY47_RS04380	COG2375	cellular response to nickel ion
GPY47_RS04410	COG1357	PFAM Pentapeptide repeats (8 copies)
GPY47_RS04415	COG3047	cAMP biosynthetic process
GPY47_RS04475	COG3835	regulator
GPY47_RS04480	COG2610	gluconate transmembrane transporter activity
GPY47_RS04485	COG1929	Belongs to the glycerate kinase type-1 family
GPY47_RS04490	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY47_RS04510	COG0456	acetyltransferase
GPY47_RS04525	COG1028	Short-chain dehydrogenase reductase Sdr
GPY47_RS04530	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY47_RS04535	COG3005	denitrification pathway
GPY47_RS04540	COG0243	molybdopterin cofactor binding
GPY47_RS04555	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
GPY47_RS04560	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GPY47_RS04565	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GPY47_RS04570	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GPY47_RS04575	COG1116	anion transmembrane transporter activity
GPY47_RS04580	COG0351	phosphomethylpyrimidine kinase
GPY47_RS04585	COG0312	modulator of DNA gyrase
GPY47_RS04590	COG0312	modulator of DNA gyrase
GPY47_RS04595	COG1901	pseudouridine methyltransferase
GPY47_RS04655	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GPY47_RS04665	COG0584	glycerophosphoryl diester phosphodiesterase
GPY47_RS04670	COG0745	RESPONSE REGULATOR receiver
GPY47_RS04690	COG0811	peptide transport
GPY47_RS04695	COG0811	peptide transport
GPY47_RS04700	COG0848	biopolymer transport protein
GPY47_RS04740	COG0803	Belongs to the bacterial solute-binding protein 9 family
GPY47_RS04745	COG1121	(ABC) transporter
GPY47_RS04750	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GPY47_RS04765	COG1770	oligopeptidase
GPY47_RS04770	COG2814	Major facilitator Superfamily
GPY47_RS04775	COG0010	Belongs to the arginase family
GPY47_RS04780	COG1166	arginine decarboxylase activity
GPY47_RS04790	COG4067	protein conserved in archaea
GPY47_RS04790	COG0189	ligase activity
GPY47_RS04795	COG0189	ligase activity
GPY47_RS04815	COG0583	DNA-binding transcription factor activity
GPY47_RS04845	COG3706	GGDEF domain
GPY47_RS04870	COG0579	oxidoreductase
GPY47_RS04880	COG1294	oxidase, subunit
GPY47_RS04885	COG1271	oxidase subunit
GPY47_RS04895	COG3033	Beta-eliminating lyase
GPY47_RS04910	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPY47_RS04925	COG3706	GGDEF domain
GPY47_RS04940	COG3706	GGDEF domain
GPY47_RS04945	COG0415	Belongs to the DNA photolyase family
GPY47_RS04950	COG3046	protein related to deoxyribodipyrimidine photolyase
GPY47_RS04965	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY47_RS04965	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY47_RS04970	COG1765	OsmC-like protein
GPY47_RS04975	COG0110	maltose O-acetyltransferase activity
GPY47_RS05005	COG1011	Hydrolase
GPY47_RS05020	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
GPY47_RS05025	COG3338	carbonate dehydratase activity
GPY47_RS05030	COG2067	long-chain fatty acid transport protein
GPY47_RS05035	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY47_RS05040	COG1136	(ABC) transporter
GPY47_RS05040	COG0577	efflux transmembrane transporter activity
GPY47_RS05055	COG1309	transcriptional regulator
GPY47_RS05060	COG3240	lipase activity
GPY47_RS05090	COG1840	ABC-type Fe3 transport system, periplasmic component
GPY47_RS05095	COG3842	ATPase activity
GPY47_RS05120	COG2990	Protein conserved in bacteria
GPY47_RS05130	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPY47_RS05135	COG2866	Carboxypeptidase
GPY47_RS05145	COG0583	DNA-binding transcription factor activity
GPY47_RS05160	COG1760	l-serine dehydratase
GPY47_RS05180	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GPY47_RS05185	COG1388	LysM domain
GPY47_RS05185	COG0741	lytic transglycosylase activity
GPY47_RS05205	COG1815	bacterial-type flagellum-dependent cell motility
GPY47_RS05210	COG1558	bacterial-type flagellum-dependent cell motility
GPY47_RS05215	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GPY47_RS05220	COG1749	Flagellar hook protein flgE
GPY47_RS05225	COG4787	bacterial-type flagellum-dependent cell motility
GPY47_RS05230	COG4786	Flagellar basal body rod
GPY47_RS05235	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GPY47_RS05240	COG1706	bacterial-type flagellum-dependent cell motility
GPY47_RS05250	COG4786	Flagellar basal body rod
GPY47_RS05250	COG1256	bacterial-type flagellum assembly
GPY47_RS05275	COG1304	FMN binding
GPY47_RS05290	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY47_RS05295	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GPY47_RS05300	COG0459	protein refolding
GPY47_RS05310	COG1280	lysine exporter protein (LysE YggA)
GPY47_RS05330	COG1309	transcriptional regulator
GPY47_RS05340	COG4303	Ethanolamine ammonia lyase large subunit
GPY47_RS05345	COG4302	ethanolamine ammonia-lyase activity
GPY47_RS05350	COG0531	amino acid
GPY47_RS05355	COG2070	2-Nitropropane dioxygenase
GPY47_RS05360	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY47_RS05360	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY47_RS05365	COG1349	DNA-binding transcription factor activity
GPY47_RS05380	COG1335	isochorismatase
GPY47_RS05390	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GPY47_RS05415	COG0583	DNA-binding transcription factor activity
GPY47_RS05430	COG3713	MltA-interacting MipA family protein
GPY47_RS05435	COG3015	lipoprotein NlpE involved in copper resistance
GPY47_RS05440	COG4175	Glycine betaine
GPY47_RS05440	COG3448	diguanylate cyclase activity
GPY47_RS05445	COG4176	ABC-type proline glycine betaine transport system permease component
GPY47_RS05450	COG1342	Belongs to the UPF0251 family
GPY47_RS05475	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPY47_RS05480	COG4948	Mandelate Racemase Muconate Lactonizing
GPY47_RS05490	COG0583	DNA-binding transcription factor activity
GPY47_RS05525	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GPY47_RS05530	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GPY47_RS05560	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY47_RS05580	COG3842	ATPase activity
GPY47_RS05610	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPY47_RS05630	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY47_RS05635	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GPY47_RS05640	COG2197	response regulator
GPY47_RS05655	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GPY47_RS05660	COG0252	asparaginase activity
GPY47_RS05670	COG0583	DNA-binding transcription factor activity
GPY47_RS05685	COG3122	Protein conserved in bacteria
GPY47_RS05690	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GPY47_RS05695	COG1012	belongs to the aldehyde dehydrogenase family
GPY47_RS05700	COG1522	sequence-specific DNA binding
GPY47_RS05705	COG3608	succinylglutamate desuccinylase aspartoacylase
GPY47_RS05710	COG0006	proline dipeptidase activity
GPY47_RS05715	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY47_RS05725	COG1028	Short-chain dehydrogenase reductase Sdr
GPY47_RS05735	COG1063	alcohol dehydrogenase
GPY47_RS05740	COG1902	pentaerythritol trinitrate reductase activity
GPY47_RS05755	COG0583	DNA-binding transcription factor activity
GPY47_RS05765	COG0513	Belongs to the DEAD box helicase family
GPY47_RS05795	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY47_RS05800	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GPY47_RS05800	COG2207	Transcriptional regulator
GPY47_RS05805	COG0583	DNA-binding transcription factor activity
GPY47_RS05810	COG1028	Short-chain dehydrogenase reductase Sdr
GPY47_RS05825	COG3746	phosphate-selective porin O and P
GPY47_RS05840	COG1028	Short-chain dehydrogenase reductase Sdr
GPY47_RS05845	COG1404	Belongs to the peptidase S8 family
GPY47_RS05900	COG1263	PTS System
GPY47_RS05900	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY47_RS05905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY47_RS05910	COG1621	beta-fructofuranosidase activity
GPY47_RS05920	COG0625	glutathione transferase activity
GPY47_RS05925	COG1686	Belongs to the peptidase S11 family
GPY47_RS05935	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPY47_RS05935	COG0678	peroxiredoxin activity
GPY47_RS05940	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GPY47_RS05955	COG1278	Cold shock
GPY47_RS05960	COG1741	Belongs to the pirin family
GPY47_RS05965	COG4667	esterase of the alpha-beta hydrolase superfamily
GPY47_RS05985	COG2194	sulfuric ester hydrolase activity
GPY47_RS05990	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GPY47_RS06000	COG2205	protein histidine kinase activity
GPY47_RS06005	COG0745	RESPONSE REGULATOR receiver
GPY47_RS06020	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPY47_RS06040	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GPY47_RS06050	COG2814	Major facilitator Superfamily
GPY47_RS06065	COG1418	mRNA catabolic process
GPY47_RS06070	COG0402	S-adenosylhomocysteine deaminase activity
GPY47_RS06075	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GPY47_RS06080	COG2239	Acts as a magnesium transporter
GPY47_RS06085	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GPY47_RS06090	COG1566	PFAM secretion protein HlyD family protein
GPY47_RS06115	COG0745	RESPONSE REGULATOR receiver
GPY47_RS06120	COG2205	protein histidine kinase activity
GPY47_RS06135	COG0531	amino acid
GPY47_RS06150	COG0583	DNA-binding transcription factor activity
GPY47_RS06170	COG0784	Response regulator, receiver
GPY47_RS06170	COG2205	protein histidine kinase activity
GPY47_RS06170	COG5002	protein histidine kinase activity
GPY47_RS06190	COG3132	Protein of unknown function, DUF480
GPY47_RS06195	COG2827	Endonuclease containing a URI domain
GPY47_RS06200	COG1879	ABC-type sugar transport system periplasmic component
GPY47_RS06205	COG0784	Response regulator, receiver
GPY47_RS06205	COG2205	protein histidine kinase activity
GPY47_RS06210	COG1846	Transcriptional regulator
GPY47_RS06260	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY47_RS06265	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY47_RS06275	COG1280	lysine exporter protein (LysE YggA)
GPY47_RS06285	COG0183	Belongs to the thiolase family
GPY47_RS06295	COG3243	poly(R)-hydroxyalkanoic acid synthase
GPY47_RS06305	COG3005	denitrification pathway
GPY47_RS06315	COG0243	molybdopterin cofactor binding
GPY47_RS06325	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GPY47_RS06330	COG3850	Histidine kinase
GPY47_RS06335	COG2197	response regulator
GPY47_RS06350	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPY47_RS06370	COG0840	transmembrane signaling receptor activity
GPY47_RS06380	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY47_RS06390	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY47_RS06395	COG2814	Major facilitator Superfamily
GPY47_RS06400	COG0840	transmembrane signaling receptor activity
GPY47_RS06405	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GPY47_RS06410	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GPY47_RS06425	COG2897	thiosulfate sulfurtransferase activity
GPY47_RS06460	COG0038	chloride channel
GPY47_RS06475	COG4989	oxidoreductase activity
GPY47_RS06490	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GPY47_RS06490	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GPY47_RS06510	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY47_RS06515	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY47_RS06520	COG1120	ATPase activity
GPY47_RS06530	COG0739	heme binding
GPY47_RS06570	COG3501	Rhs element vgr protein
GPY47_RS06595	COG0515	serine threonine protein kinase
GPY47_RS06630	COG1522	sequence-specific DNA binding
GPY47_RS06695	COG2814	Major facilitator Superfamily
GPY47_RS06705	COG0583	DNA-binding transcription factor activity
GPY47_RS06710	COG4221	oxidoreductase activity
GPY47_RS06715	COG0589	response to stress
GPY47_RS06725	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GPY47_RS06725	COG2111	Na H antiporter
GPY47_RS06730	COG1006	Multisubunit Na H antiporter MnhC subunit
GPY47_RS06745	COG2212	antiporter activity
GPY47_RS06750	COG1320	monovalent cation:proton antiporter activity
GPY47_RS06755	COG2188	Transcriptional regulator
GPY47_RS06760	COG1486	melibiose metabolic process
GPY47_RS06765	COG1263	PTS System
GPY47_RS06765	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY47_RS06770	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPY47_RS06800	COG1022	Amp-dependent synthetase and ligase
GPY47_RS06830	COG0500	methyltransferase
GPY47_RS06845	COG3527	Alpha-acetolactate decarboxylase
GPY47_RS06855	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY47_RS06870	COG1294	oxidase, subunit
GPY47_RS06875	COG1271	oxidase subunit
GPY47_RS06880	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY47_RS06895	COG3264	Mechanosensitive ion channel
GPY47_RS06895	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GPY47_RS06915	COG1024	Enoyl-CoA hydratase
GPY47_RS06920	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GPY47_RS06925	COG1960	acyl-CoA dehydrogenase activity
GPY47_RS06935	COG0183	Belongs to the thiolase family
GPY47_RS06945	COG1960	acyl-CoA dehydrogenase activity
GPY47_RS06950	COG1024	Enoyl-CoA hydratase
GPY47_RS06965	COG1028	Short-chain dehydrogenase reductase Sdr
GPY47_RS06970	COG0745	RESPONSE REGULATOR receiver
GPY47_RS06970	COG3706	GGDEF domain
GPY47_RS06975	COG1309	transcriptional regulator
GPY47_RS06980	COG1012	belongs to the aldehyde dehydrogenase family
GPY47_RS06995	COG4176	ABC-type proline glycine betaine transport system permease component
GPY47_RS07000	COG4175	Glycine betaine
GPY47_RS07000	COG0517	IMP dehydrogenase activity
GPY47_RS07015	COG0330	HflC and HflK could
GPY47_RS07030	COG0784	Response regulator, receiver
GPY47_RS07030	COG2205	protein histidine kinase activity
GPY47_RS07040	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GPY47_RS07090	COG5001	Diguanylate cyclase
GPY47_RS07095	COG1869	D-ribose catabolic process
GPY47_RS07100	COG1129	ABC transporter
GPY47_RS07105	COG1172	Belongs to the binding-protein-dependent transport system permease family
GPY47_RS07110	COG1879	ABC-type sugar transport system periplasmic component
GPY47_RS07115	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY47_RS07120	COG1609	Transcriptional regulator
GPY47_RS07130	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
GPY47_RS07140	COG4607	ABC-type enterochelin transport system periplasmic component
GPY47_RS07145	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPY47_RS07150	COG4605	iron ion homeostasis
GPY47_RS07155	COG4604	ABC transporter, ATP-binding protein
GPY47_RS07160	COG0789	Transcriptional regulator
GPY47_RS07170	COG1629	transport
GPY47_RS07170	COG4771	TonB-dependent receptor
GPY47_RS07200	COG1289	transmembrane transporter activity
GPY47_RS07205	COG0210	DNA helicase
GPY47_RS07210	COG1803	Methylglyoxal synthase
GPY47_RS07215	COG1879	ABC-type sugar transport system periplasmic component
GPY47_RS07220	COG2205	protein histidine kinase activity
GPY47_RS07220	COG2198	Histidine kinase
GPY47_RS07220	COG0784	Response regulator, receiver
GPY47_RS07235	COG0745	RESPONSE REGULATOR receiver
GPY47_RS07240	COG3119	arylsulfatase activity
GPY47_RS07250	COG3119	arylsulfatase activity
GPY47_RS07255	COG0641	radical SAM
GPY47_RS07260	COG0714	Associated with various cellular activities
GPY47_RS07290	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPY47_RS07295	COG0583	DNA-binding transcription factor activity
GPY47_RS07300	COG1597	lipid kinase activity
GPY47_RS07305	COG3111	PFAM Bacterial OB fold (BOF) protein
GPY47_RS07330	COG3069	C4-dicarboxylate transmembrane transporter activity
GPY47_RS07340	COG1214	PFAM Peptidase M22, glycoprotease
GPY47_RS07340	COG0456	acetyltransferase
GPY47_RS07360	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GPY47_RS07365	COG0784	Response regulator, receiver
GPY47_RS07365	COG2205	protein histidine kinase activity
GPY47_RS07370	COG5001	Diguanylate cyclase
GPY47_RS07370	COG3300	MHYT domain
GPY47_RS07375	COG2197	response regulator
GPY47_RS07380	COG3706	GGDEF domain
GPY47_RS07390	COG0745	RESPONSE REGULATOR receiver
GPY47_RS07400	COG0784	Response regulator, receiver
GPY47_RS07400	COG0835	chemotaxis
GPY47_RS07415	COG2962	Rard protein
GPY47_RS07435	COG2076	Multidrug Resistance protein
GPY47_RS07465	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GPY47_RS07465	COG0069	glutamate synthase activity
GPY47_RS07470	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GPY47_RS07485	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GPY47_RS07485	COG2755	lipolytic protein G-D-S-L family
GPY47_RS07495	COG1902	pentaerythritol trinitrate reductase activity
GPY47_RS07500	COG0346	lactoylglutathione lyase activity
GPY47_RS07520	COG2239	Acts as a magnesium transporter
GPY47_RS07550	COG0242	peptide deformylase activity
GPY47_RS07590	COG2176	DNA-directed DNA polymerase activity
GPY47_RS07645	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GPY47_RS07650	COG0697	spore germination
GPY47_RS07655	COG0583	DNA-binding transcription factor activity
GPY47_RS07660	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPY47_RS07665	COG0346	lactoylglutathione lyase activity
GPY47_RS07675	COG0509	glycine decarboxylation via glycine cleavage system
GPY47_RS07680	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GPY47_RS07690	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GPY47_RS07720	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY47_RS07720	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
GPY47_RS07720	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPY47_RS07725	COG1105	Belongs to the carbohydrate kinase PfkB family
GPY47_RS07735	COG1609	Transcriptional regulator
GPY47_RS07750	COG2203	Gaf domain
GPY47_RS07750	COG2199	diguanylate cyclase activity
GPY47_RS07750	COG2200	EAL domain
GPY47_RS07755	COG0765	amino acid transport
GPY47_RS07760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY47_RS07765	COG0765	amino acid transport
GPY47_RS07770	COG1126	abc transporter atp-binding protein
GPY47_RS07780	COG1979	alcohol dehydrogenase
GPY47_RS07785	COG2207	Transcriptional regulator
GPY47_RS07800	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GPY47_RS07805	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GPY47_RS07810	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY47_RS07825	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPY47_RS07830	COG0840	transmembrane signaling receptor activity
GPY47_RS07840	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
GPY47_RS07845	COG0513	Belongs to the DEAD box helicase family
GPY47_RS07865	COG3038	cytochrome b561
GPY47_RS07870	COG2353	YceI-like domain
GPY47_RS07875	COG2116	formate transmembrane transporter activity
GPY47_RS07880	COG0583	DNA-binding transcription factor activity
GPY47_RS07890	COG3593	DNA synthesis involved in DNA repair
GPY47_RS07895	COG0737	Belongs to the 5'-nucleotidase family
GPY47_RS07920	COG2267	carboxylic ester hydrolase activity
GPY47_RS07925	COG2067	long-chain fatty acid transport protein
GPY47_RS07940	COG2050	protein possibly involved in aromatic compounds catabolism
GPY47_RS07950	COG4533	DNA binding
GPY47_RS07985	COG5001	Diguanylate cyclase
GPY47_RS07985	COG3300	MHYT domain
GPY47_RS07990	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GPY47_RS08000	COG4181	ATPase activity
GPY47_RS08005	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GPY47_RS08015	COG1984	allophanate hydrolase subunit 2
GPY47_RS08020	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GPY47_RS08025	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GPY47_RS08030	COG5002	protein histidine kinase activity
GPY47_RS08030	COG5001	Diguanylate cyclase
GPY47_RS08030	COG3447	MASE1 domain protein
GPY47_RS08050	COG0583	DNA-binding transcription factor activity
GPY47_RS08055	COG0045	succinate-CoA ligase (ADP-forming) activity
GPY47_RS08055	COG1042	CoA-binding domain protein
GPY47_RS08055	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY47_RS08065	COG1181	Belongs to the D-alanine--D-alanine ligase family
GPY47_RS08075	COG0023	Translation Initiation Factor
GPY47_RS08085	COG0583	DNA-binding transcription factor activity
GPY47_RS08100	COG3140	Belongs to the UPF0181 family
GPY47_RS08125	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GPY47_RS08130	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GPY47_RS08145	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPY47_RS08150	COG1136	(ABC) transporter
GPY47_RS08155	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPY47_RS08165	COG2333	competence protein COMEC
GPY47_RS08165	COG0658	competence protein
GPY47_RS08170	COG1132	(ABC) transporter
GPY47_RS08190	COG2719	SpoVR family
GPY47_RS08195	COG2718	Belongs to the UPF0229 family
GPY47_RS08200	COG2766	serine protein kinase
GPY47_RS08205	COG3013	Belongs to the UPF0304 family
GPY47_RS08215	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GPY47_RS08225	COG1882	Formate acetyltransferase
GPY47_RS08255	COG4215	(ABC) transporter
GPY47_RS08270	COG0708	Exodeoxyribonuclease III
GPY47_RS08280	COG3923	Primosomal replication protein n
GPY47_RS08285	COG0730	response to heat
GPY47_RS08290	COG1199	ATP-dependent helicase activity
GPY47_RS08295	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPY47_RS08300	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GPY47_RS08305	COG1187	pseudouridine synthase activity
GPY47_RS08320	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GPY47_RS08325	COG0542	response to heat
GPY47_RS08330	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GPY47_RS08335	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
GPY47_RS08340	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GPY47_RS08360	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GPY47_RS08365	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GPY47_RS08370	COG0297	glycogen (starch) synthase activity
GPY47_RS08390	COG3070	regulator of competence-specific genes
GPY47_RS08395	COG1609	Transcriptional regulator
GPY47_RS08400	COG3381	protein complex oligomerization
GPY47_RS08405	COG0745	RESPONSE REGULATOR receiver
GPY47_RS08410	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GPY47_RS08415	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPY47_RS08425	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
GPY47_RS08430	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GPY47_RS08450	COG0189	ligase activity
GPY47_RS08450	COG4067	protein conserved in archaea
GPY47_RS08460	COG0500	methyltransferase
GPY47_RS08470	COG1801	Protein of unknown function DUF72
GPY47_RS08480	COG0217	transcriptional regulatory protein
GPY47_RS08485	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GPY47_RS08490	COG0632	four-way junction helicase activity
GPY47_RS08495	COG2255	four-way junction helicase activity
GPY47_RS08500	COG1271	oxidase subunit
GPY47_RS08505	COG1294	oxidase, subunit
GPY47_RS08510	COG4890	Cyd operon protein YbgT
GPY47_RS08520	COG0824	Thioesterase
GPY47_RS08525	COG0811	peptide transport
GPY47_RS08540	COG0823	Involved in the tonB-independent uptake of proteins
GPY47_RS08545	COG2885	chlorophyll binding
GPY47_RS08550	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
GPY47_RS08555	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GPY47_RS08565	COG3766	membrane
GPY47_RS08575	COG0754	glutathionylspermidine amidase activity
GPY47_RS08585	COG0784	Response regulator, receiver
GPY47_RS08585	COG5002	protein histidine kinase activity
GPY47_RS08600	COG1294	oxidase, subunit
GPY47_RS08605	COG1271	oxidase subunit
GPY47_RS08625	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY47_RS08630	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY47_RS08655	COG3568	Endonuclease Exonuclease Phosphatase
GPY47_RS08680	COG0583	DNA-binding transcription factor activity
GPY47_RS08690	COG0686	Belongs to the AlaDH PNT family
GPY47_RS08700	COG1674	ftsk spoiiie
GPY47_RS08710	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GPY47_RS08730	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GPY47_RS08755	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GPY47_RS08775	COG0300	oxidoreductase activity
GPY47_RS08790	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GPY47_RS08800	COG2268	Band 7 protein
GPY47_RS08810	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GPY47_RS08815	COG2915	High frequency lysogenization protein hflD homolog
GPY47_RS08830	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPY47_RS08840	COG1757	Na H antiporter
GPY47_RS08850	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GPY47_RS08860	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GPY47_RS08860	COG0131	Imidazoleglycerol-phosphate dehydratase
GPY47_RS08865	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GPY47_RS08870	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GPY47_RS08875	COG0107	imidazoleglycerol-phosphate synthase activity
GPY47_RS08880	COG0140	phosphoribosyl-ATP diphosphatase activity
GPY47_RS08880	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GPY47_RS08885	COG3012	SEC-C Motif Domain Protein
GPY47_RS08890	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GPY47_RS08895	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY47_RS08900	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GPY47_RS08905	COG0215	cysteine-tRNA ligase activity
GPY47_RS08910	COG1435	thymidine kinase activity
GPY47_RS08940	COG2116	formate transmembrane transporter activity
GPY47_RS08985	COG0390	transport system, permease component
GPY47_RS08990	COG4459	periplasmic nitrate reductase
GPY47_RS08995	COG3005	denitrification pathway
GPY47_RS09000	COG0243	molybdopterin cofactor binding
GPY47_RS09015	COG1227	inorganic diphosphatase activity
GPY47_RS09025	COG4172	Belongs to the ABC transporter superfamily
GPY47_RS09035	COG4171	peptide transport system, permease
GPY47_RS09040	COG4168	peptide transport system, permease
GPY47_RS09050	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GPY47_RS09055	COG1842	Phage shock protein A
GPY47_RS09065	COG1983	PspC domain protein
GPY47_RS09085	COG2818	Glycosylase
GPY47_RS09090	COG5380	lipid catabolic process
GPY47_RS09095	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GPY47_RS09100	COG0626	cystathionine gamma-synthase activity
GPY47_RS09110	COG0733	neurotransmitter:sodium symporter activity
GPY47_RS09115	COG0564	pseudouridine synthase activity
GPY47_RS09125	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPY47_RS09130	COG1151	hydroxylamine reductase activity
GPY47_RS09135	COG3604	Transcriptional regulator
GPY47_RS09150	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GPY47_RS09155	COG4136	ATPase activity
GPY47_RS09160	COG4135	transport system, permease component
GPY47_RS09165	COG4134	Bacterial extracellular solute-binding protein
GPY47_RS09175	COG3313	Fe-S protein
GPY47_RS09200	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GPY47_RS09205	COG2205	protein histidine kinase activity
GPY47_RS09210	COG0745	RESPONSE REGULATOR receiver
GPY47_RS09220	COG1061	Type III restriction enzyme res subunit
GPY47_RS09225	COG1187	pseudouridine synthase activity
GPY47_RS09230	COG2814	Major facilitator Superfamily
GPY47_RS09240	COG0702	epimerase
GPY47_RS09245	COG0534	Mate efflux family protein
GPY47_RS09265	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GPY47_RS09275	COG1960	acyl-CoA dehydrogenase activity
GPY47_RS09280	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GPY47_RS09285	COG3273	potassium ion transport
GPY47_RS09285	COG2985	domain, Protein
GPY47_RS09290	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPY47_RS09300	COG1737	Transcriptional regulator
GPY47_RS09305	COG0076	glutamate decarboxylase activity
GPY47_RS09315	COG2431	L-lysine efflux transmembrane transporter activity
GPY47_RS09330	COG3070	regulator of competence-specific genes
GPY47_RS09345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY47_RS09345	COG4191	Histidine kinase
GPY47_RS09355	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GPY47_RS09365	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GPY47_RS09370	COG4988	ABC transporter
GPY47_RS09375	COG0492	ferredoxin-NADP+ reductase activity
GPY47_RS09395	COG0745	RESPONSE REGULATOR receiver
GPY47_RS09395	COG3706	GGDEF domain
GPY47_RS09400	COG0471	metal ion transport
GPY47_RS09405	COG2949	membrane
GPY47_RS09410	COG0281	malic enzyme
GPY47_RS09415	COG1643	Atp-dependent helicase
GPY47_RS09430	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GPY47_RS09465	COG0247	lactate metabolic process
GPY47_RS09465	COG0277	FAD linked oxidase domain protein
GPY47_RS09485	COG2986	histidine ammonia-lyase
GPY47_RS09490	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GPY47_RS09495	COG0010	Belongs to the arginase family
GPY47_RS09500	COG1228	amidohydrolase
GPY47_RS09520	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GPY47_RS09530	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GPY47_RS09540	COG0393	Putative heavy-metal-binding
GPY47_RS09570	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GPY47_RS09575	COG0072	phenylalanine-tRNA ligase activity
GPY47_RS09575	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY47_RS09585	COG0776	regulation of translation
GPY47_RS09595	COG0500	methyltransferase
GPY47_RS09600	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GPY47_RS09605	COG0295	cytidine deaminase activity
GPY47_RS09610	COG1346	cytolysis
GPY47_RS09615	COG1380	Effector of murein hydrolase LrgA
GPY47_RS09620	COG2925	Exonuclease
GPY47_RS09630	COG0702	epimerase
GPY47_RS09635	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GPY47_RS09640	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
GPY47_RS09660	COG2988	succinylglutamate desuccinylase activity
GPY47_RS09665	COG4139	cobalamin transport
GPY47_RS09670	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
GPY47_RS09690	COG0583	DNA-binding transcription factor activity
GPY47_RS09700	COG1451	nucleotide metabolic process
GPY47_RS09735	COG3938	Belongs to the proline racemase family
GPY47_RS09750	COG2423	ornithine cyclodeaminase activity
GPY47_RS09755	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GPY47_RS09760	COG3842	ATPase activity
GPY47_RS09765	COG1176	ABC-type spermidine putrescine transport system, permease component I
GPY47_RS09770	COG1177	transmembrane transport
GPY47_RS09785	COG3291	Pkd domain containing protein
GPY47_RS09805	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY47_RS09810	COG0601	transmembrane transport
GPY47_RS09820	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPY47_RS09830	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GPY47_RS09840	COG0625	glutathione transferase activity
GPY47_RS09890	COG3755	Protein conserved in bacteria
GPY47_RS09915	COG1742	UPF0060 membrane protein
GPY47_RS09930	COG1757	Na H antiporter
GPY47_RS09935	COG0174	glutamine synthetase
GPY47_RS09945	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GPY47_RS09950	COG1396	sequence-specific DNA binding
GPY47_RS09950	COG1917	Cupin 2, conserved barrel domain protein
GPY47_RS09955	COG1012	belongs to the aldehyde dehydrogenase family
GPY47_RS09960	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPY47_RS09970	COG2957	Belongs to the agmatine deiminase family
GPY47_RS09975	COG1012	belongs to the aldehyde dehydrogenase family
GPY47_RS09980	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GPY47_RS09985	COG2200	EAL domain
GPY47_RS09995	COG1846	Transcriptional regulator
GPY47_RS10000	COG2315	Protein conserved in bacteria
GPY47_RS10040	COG3063	Type IV pilus biogenesis stability protein PilW
GPY47_RS10045	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GPY47_RS10060	COG1560	Kdo2-lipid A biosynthetic process
GPY47_RS10070	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GPY47_RS10150	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GPY47_RS10155	COG1280	lysine exporter protein (LysE YggA)
GPY47_RS10165	COG1115	amino acid carrier protein
GPY47_RS10190	COG1368	sulfuric ester hydrolase activity
GPY47_RS10195	COG2113	Glycine betaine
GPY47_RS10200	COG4176	ABC-type proline glycine betaine transport system permease component
GPY47_RS10220	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPY47_RS10225	COG0456	acetyltransferase
GPY47_RS10230	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GPY47_RS10235	COG0662	Cupin 2, conserved barrel domain protein
GPY47_RS10240	COG0527	aspartate kinase activity
GPY47_RS10245	COG3119	arylsulfatase activity
GPY47_RS10260	COG0641	radical SAM
GPY47_RS10275	COG3119	arylsulfatase activity
GPY47_RS10300	COG1538	Outer membrane efflux protein
GPY47_RS10315	COG1349	DNA-binding transcription factor activity
GPY47_RS10320	COG0673	inositol 2-dehydrogenase activity
GPY47_RS10325	COG4702	Belongs to the UPF0303 family
GPY47_RS10330	COG3706	GGDEF domain
GPY47_RS10330	COG0745	RESPONSE REGULATOR receiver
GPY47_RS10350	COG0471	metal ion transport
GPY47_RS10365	COG3300	MHYT domain
GPY47_RS10365	COG5001	Diguanylate cyclase
GPY47_RS10380	COG1328	CTP reductase activity
GPY47_RS10385	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GPY47_RS10395	COG0861	Integral membrane protein TerC family
GPY47_RS10405	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GPY47_RS10415	COG0814	amino acid
GPY47_RS10430	COG1120	ATPase activity
GPY47_RS10435	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GPY47_RS10445	COG4774	siderophore transport
GPY47_RS10455	COG1132	(ABC) transporter
GPY47_RS10460	COG1132	(ABC) transporter
GPY47_RS10475	COG0583	DNA-binding transcription factor activity
GPY47_RS10480	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
GPY47_RS10500	COG0443	Heat shock 70 kDa protein
GPY47_RS10505	COG0443	Heat shock 70 kDa protein
GPY47_RS10550	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GPY47_RS10555	COG1643	Atp-dependent helicase
GPY47_RS10570	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPY47_RS10580	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GPY47_RS10585	COG1215	transferase activity, transferring glycosyl groups
GPY47_RS10590	COG0438	transferase activity, transferring glycosyl groups
GPY47_RS10625	COG0297	glycogen (starch) synthase activity
GPY47_RS10630	COG2204	response regulator
GPY47_RS10660	COG1793	dna ligase
GPY47_RS10670	COG0534	Mate efflux family protein
GPY47_RS10675	COG0307	riboflavin synthase, alpha
GPY47_RS10695	COG3706	GGDEF domain
GPY47_RS10705	COG0791	NLP P60 protein
GPY47_RS10745	COG1940	carbohydrate kinase activity
GPY47_RS10755	COG0303	'Molybdopterin
GPY47_RS10760	COG0746	molybdenum cofactor guanylyltransferase activity
GPY47_RS10765	COG3842	ATPase activity
GPY47_RS10780	COG2204	response regulator
GPY47_RS10785	COG4191	Histidine kinase
GPY47_RS10885	COG1802	Transcriptional regulator
GPY47_RS10885	COG4626	Terminase
GPY47_RS10995	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GPY47_RS11000	COG0488	(ABC) transporter
GPY47_RS11005	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GPY47_RS11025	COG3381	protein complex oligomerization
GPY47_RS11035	COG0243	molybdopterin cofactor binding
GPY47_RS11035	COG3383	formate dehydrogenase (NAD+) activity
GPY47_RS11040	COG0437	4 iron, 4 sulfur cluster binding
GPY47_RS11070	COG0004	ammonium transporteR
GPY47_RS11075	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GPY47_RS11080	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY47_RS11085	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPY47_RS11090	COG1177	transmembrane transport
GPY47_RS11095	COG1176	ABC-type spermidine putrescine transport system, permease component I
GPY47_RS11100	COG3842	ATPase activity
GPY47_RS11125	COG0589	response to stress
GPY47_RS11130	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY47_RS11145	COG2217	Heavy metal translocating P-type atpase
GPY47_RS11155	COG2010	Cytochrome c
GPY47_RS11170	COG3278	Belongs to the heme-copper respiratory oxidase family
GPY47_RS11185	COG2205	protein histidine kinase activity
GPY47_RS11185	COG0784	Response regulator, receiver
GPY47_RS11200	COG3120	sequence-specific DNA binding
GPY47_RS11205	COG1067	ATP-dependent peptidase activity
GPY47_RS11210	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPY47_RS11235	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GPY47_RS11235	COG0116	Belongs to the methyltransferase superfamily
GPY47_RS11245	COG0167	dihydroorotate dehydrogenase activity
GPY47_RS11250	COG2902	Dehydrogenase
GPY47_RS11260	COG0308	aminopeptidase N
GPY47_RS11275	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
GPY47_RS11280	COG1956	GAF domain-containing protein
GPY47_RS11285	COG1132	(ABC) transporter
GPY47_RS11290	COG2995	paraquat-inducible protein a
GPY47_RS11295	COG3008	intermembrane lipid transfer
GPY47_RS11320	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY47_RS11325	COG1666	GTP binding
GPY47_RS11335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY47_RS11340	COG4597	amino acid ABC transporter
GPY47_RS11345	COG0765	amino acid transport
GPY47_RS11350	COG1126	abc transporter atp-binding protein
GPY47_RS11355	COG0670	Belongs to the BI1 family
GPY47_RS11365	COG2920	part of a sulfur-relay system
GPY47_RS11370	COG1254	Belongs to the acylphosphatase family
GPY47_RS11395	COG2885	chlorophyll binding
GPY47_RS11420	COG2203	Gaf domain
GPY47_RS11420	COG2199	diguanylate cyclase activity
GPY47_RS11425	COG1414	Transcriptional regulator
GPY47_RS11435	COG0656	L-ascorbic acid biosynthetic process
GPY47_RS11440	COG0583	DNA-binding transcription factor activity
GPY47_RS11450	COG0583	DNA-binding transcription factor activity
GPY47_RS11455	COG2814	Major facilitator Superfamily
GPY47_RS11475	COG1335	isochorismatase
GPY47_RS11480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY47_RS11495	COG1410	methionine synthase
GPY47_RS11495	COG0646	methionine synthase
GPY47_RS11500	COG1126	abc transporter atp-binding protein
GPY47_RS11505	COG0765	amino acid transport
GPY47_RS11510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPY47_RS11525	COG0583	DNA-binding transcription factor activity
GPY47_RS11540	COG0583	DNA-binding transcription factor activity
GPY47_RS11545	COG0583	DNA-binding transcription factor activity
GPY47_RS11560	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GPY47_RS11565	COG0602	queuosine metabolic process
GPY47_RS11570	COG0561	phosphatase activity
GPY47_RS11595	COG2828	Protein conserved in bacteria
GPY47_RS11605	COG0372	Belongs to the citrate synthase family
GPY47_RS11610	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GPY47_RS11645	COG0730	response to heat
GPY47_RS11665	COG0457	Tetratricopeptide repeat
GPY47_RS11730	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GPY47_RS11735	COG4790	Type iii secretion
GPY47_RS11740	COG4794	Type iii secretion
GPY47_RS11745	COG4791	protein targeting
GPY47_RS11750	COG4792	protein secretion
GPY47_RS11755	COG2207	Transcriptional regulator
GPY47_RS11785	COG3177	Filamentation induced by cAMP protein fic
GPY47_RS11805	COG4669	(LipO)protein
GPY47_RS11875	COG1012	belongs to the aldehyde dehydrogenase family
GPY47_RS11880	COG3284	Transcriptional regulator
GPY47_RS11900	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GPY47_RS11905	COG0363	glucosamine-6-phosphate deaminase activity
GPY47_RS11910	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GPY47_RS11915	COG2207	Transcriptional regulator
GPY47_RS11925	COG4565	transcriptional regulatory protein
GPY47_RS11930	COG3290	protein histidine kinase activity
GPY47_RS11945	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY47_RS11975	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
GPY47_RS11985	COG2985	domain, Protein
GPY47_RS12010	COG2272	Belongs to the type-B carboxylesterase lipase family
GPY47_RS12015	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GPY47_RS12020	COG0729	surface antigen
GPY47_RS12030	COG1280	lysine exporter protein (LysE YggA)
GPY47_RS12040	COG5507	3-demethylubiquinone-9 3-methyltransferase
GPY47_RS12060	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GPY47_RS12065	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY47_RS12070	COG0110	maltose O-acetyltransferase activity
GPY47_RS12420	COG0384	phenazine biosynthesis protein PhzF
GPY47_RS12580	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPY47_RS12590	COG3768	UPF0283 membrane protein
GPY47_RS12595	COG3106	COG3106 Predicted ATPase
GPY47_RS12615	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GPY47_RS12620	COG0784	Response regulator, receiver
GPY47_RS12620	COG2205	protein histidine kinase activity
GPY47_RS12630	COG0494	nUDIX hydrolase
GPY47_RS12635	COG0814	amino acid
GPY47_RS12640	COG1760	l-serine dehydratase
GPY47_RS12645	COG2200	EAL domain
GPY47_RS12655	COG0720	synthase
GPY47_RS12660	COG0840	transmembrane signaling receptor activity
GPY47_RS12665	COG0017	Asparaginyl-tRNA synthetase
GPY47_RS12675	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GPY47_RS12690	COG1448	Aminotransferase
GPY47_RS12710	COG0840	transmembrane signaling receptor activity
GPY47_RS12715	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPY47_RS12745	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GPY47_RS12760	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPY47_RS12765	COG3108	Peptidase M15
GPY47_RS12770	COG2989	Protein conserved in bacteria
GPY47_RS12795	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GPY47_RS12805	COG3088	subunit of a heme lyase
GPY47_RS12805	COG4235	cytochrome complex assembly
GPY47_RS12815	COG1138	Cytochrome C-type biogenesis protein
GPY47_RS12820	COG3301	Polysulphide reductase, NrfD
GPY47_RS12825	COG0437	4 iron, 4 sulfur cluster binding
GPY47_RS12835	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
GPY47_RS12855	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPY47_RS12860	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GPY47_RS12865	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GPY47_RS12895	COG0019	diaminopimelate decarboxylase activity
GPY47_RS12935	COG0322	excinuclease ABC activity
GPY47_RS12940	COG2197	response regulator
GPY47_RS12945	COG0417	DNA replication proofreading
GPY47_RS12965	COG1187	pseudouridine synthase activity
GPY47_RS12975	COG0009	L-threonylcarbamoyladenylate synthase
GPY47_RS12980	COG0613	PHP domain protein
GPY47_RS12990	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GPY47_RS12995	COG0512	Glutamine amidotransferase of anthranilate synthase
GPY47_RS13005	COG0135	phosphoribosylanthranilate isomerase activity
GPY47_RS13005	COG0134	indole-3-glycerol-phosphate synthase activity
GPY47_RS13015	COG0159	tryptophan synthase activity
GPY47_RS13020	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY47_RS13025	COG0318	PFAM AMP-dependent synthetase and ligase
GPY47_RS13030	COG1301	dicarboxylic acid transport
GPY47_RS13050	COG2917	probably involved in intracellular septation
GPY47_RS13055	COG1607	acyl-coa hydrolase
GPY47_RS13060	COG2350	Protein conserved in bacteria
GPY47_RS13070	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GPY47_RS13075	COG0583	DNA-binding transcription factor activity
GPY47_RS13090	COG5001	Diguanylate cyclase
GPY47_RS13095	COG1032	radical SAM domain protein
GPY47_RS13115	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GPY47_RS13120	COG0463	Glycosyl transferase, family 2
GPY47_RS13125	COG0745	RESPONSE REGULATOR receiver
GPY47_RS13130	COG5002	protein histidine kinase activity
GPY47_RS13130	COG3850	Histidine kinase
GPY47_RS13160	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GPY47_RS13180	COG0577	efflux transmembrane transporter activity
GPY47_RS13180	COG1136	(ABC) transporter
GPY47_RS13185	COG0577	efflux transmembrane transporter activity
GPY47_RS13185	COG1136	(ABC) transporter
GPY47_RS13190	COG0577	efflux transmembrane transporter activity
GPY47_RS13190	COG1136	(ABC) transporter
GPY47_RS13200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY47_RS13220	COG3118	belongs to the thioredoxin family
GPY47_RS13225	COG4232	protein-disulfide reductase activity
GPY47_RS13260	COG2863	cytochrome
GPY47_RS13265	COG3258	Cytochrome c
GPY47_RS13270	COG2995	paraquat-inducible protein a
GPY47_RS13275	COG3008	intermembrane lipid transfer
GPY47_RS13275	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GPY47_RS13295	COG4166	transmembrane transport
GPY47_RS13305	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
GPY47_RS13310	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
GPY47_RS13320	COG0539	negative regulation of cytoplasmic translation
GPY47_RS13325	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GPY47_RS13330	COG0616	signal peptide processing
GPY47_RS13335	COG1028	Short-chain dehydrogenase reductase Sdr
GPY47_RS13350	COG0587	DNA-directed DNA polymerase activity
GPY47_RS13355	COG0835	chemotaxis
GPY47_RS13355	COG0784	Response regulator, receiver
GPY47_RS13360	COG1940	carbohydrate kinase activity
GPY47_RS13365	COG0469	pyruvate kinase activity
GPY47_RS13370	COG4667	esterase of the alpha-beta hydrolase superfamily
GPY47_RS13385	COG0733	neurotransmitter:sodium symporter activity
GPY47_RS13400	COG1263	PTS System
GPY47_RS13400	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY47_RS13405	COG0084	hydrolase, TatD family'
GPY47_RS13410	COG0470	DNA polymerase III
GPY47_RS13415	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GPY47_RS13420	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GPY47_RS13450	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GPY47_RS13455	COG0416	fatty acid biosynthetic process
GPY47_RS13465	COG1399	metal-binding, possibly nucleic acid-binding protein
GPY47_RS13470	COG0424	maF-like protein
GPY47_RS13480	COG1530	ribonuclease E activity
GPY47_RS13485	COG0659	secondary active sulfate transmembrane transporter activity
GPY47_RS13490	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GPY47_RS13495	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
GPY47_RS13505	COG0572	uridine kinase
GPY47_RS13515	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY47_RS13515	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPY47_RS13525	COG2186	Transcriptional regulator
GPY47_RS13530	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GPY47_RS13535	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GPY47_RS13540	COG3318	Belongs to the UPF0149 family
GPY47_RS13540	COG3012	SEC-C Motif Domain Protein
GPY47_RS13545	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPY47_RS13550	COG3706	GGDEF domain
GPY47_RS13555	COG0366	Alpha amylase catalytic
GPY47_RS13560	COG1122	ATPase activity
GPY47_RS13565	COG4120	Belongs to the binding-protein-dependent transport system permease family
GPY47_RS13575	COG3092	negative regulation of chromosome organization
GPY47_RS13580	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GPY47_RS13585	COG0280	phosphate acetyltransferase
GPY47_RS13585	COG0857	belongs to the CobB CobQ family
GPY47_RS13595	COG0435	Glutathione S-transferase
GPY47_RS13605	COG0444	Belongs to the ABC transporter superfamily
GPY47_RS13610	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY47_RS13615	COG0601	transmembrane transport
GPY47_RS13625	COG0314	molybdopterin synthase activity
GPY47_RS13630	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GPY47_RS13635	COG0315	cyclic pyranopterin monophosphate synthase activity
GPY47_RS13640	COG0521	Mo-molybdopterin cofactor biosynthetic process
GPY47_RS13645	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GPY47_RS13650	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GPY47_RS13655	COG2198	Histidine kinase
GPY47_RS13660	COG2204	response regulator
GPY47_RS13665	COG0556	nucleotide-excision repair
GPY47_RS13675	COG1882	Formate acetyltransferase
GPY47_RS13680	COG4657	Part of a membrane complex involved in electron transport
GPY47_RS13685	COG2878	Part of a membrane complex involved in electron transport
GPY47_RS13690	COG4656	Part of a membrane complex involved in electron transport
GPY47_RS13695	COG4658	electron transport chain
GPY47_RS13700	COG4659	FMN binding
GPY47_RS13705	COG4660	Part of a membrane complex involved in electron transport
GPY47_RS13710	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GPY47_RS13715	COG0346	lactoylglutathione lyase activity
GPY47_RS13725	COG2885	chlorophyll binding
GPY47_RS13735	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GPY47_RS13740	COG2056	Na+-H+ antiporter family
GPY47_RS13750	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GPY47_RS13770	COG1454	alcohol dehydrogenase
GPY47_RS13770	COG1012	belongs to the aldehyde dehydrogenase family
GPY47_RS13775	COG2095	MarC family integral membrane protein
GPY47_RS13780	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY47_RS13785	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GPY47_RS13790	COG1757	Na H antiporter
GPY47_RS13805	COG3081	Nucleoid-associated protein
GPY47_RS13810	COG3082	Protein of unknown function (DUF1414)
GPY47_RS13815	COG3083	sulfuric ester hydrolase activity
GPY47_RS13825	COG0123	including yeast histone deacetylase and acetoin utilization protein
GPY47_RS13840	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GPY47_RS13845	COG0778	Nitroreductase
GPY47_RS13855	COG0446	pyridine nucleotide-disulphide oxidoreductase
GPY47_RS13855	COG1902	pentaerythritol trinitrate reductase activity
GPY47_RS13860	COG0616	signal peptide processing
GPY47_RS13865	COG0252	asparaginase activity
GPY47_RS13870	COG3139	Protein of unknown function (DUF1315)
GPY47_RS13880	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY47_RS13885	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPY47_RS13900	COG2226	methyltransferase
GPY47_RS13915	COG1785	Belongs to the alkaline phosphatase family
GPY47_RS13925	COG0346	lactoylglutathione lyase activity
GPY47_RS13930	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
GPY47_RS13935	COG0668	transmembrane transport
GPY47_RS13940	COG2983	Belongs to the UPF0260 family
GPY47_RS13945	COG2261	transglycosylase associated protein
GPY47_RS13955	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GPY47_RS13960	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GPY47_RS13965	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GPY47_RS13975	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GPY47_RS13980	COG2832	Protein of unknown function (DUF454)
GPY47_RS13990	COG0745	RESPONSE REGULATOR receiver
GPY47_RS13995	COG0583	DNA-binding transcription factor activity
GPY47_RS14000	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GPY47_RS14005	COG1286	toxin biosynthetic process
GPY47_RS14010	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
GPY47_RS14015	COG0285	dihydrofolate synthase activity
GPY47_RS14020	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GPY47_RS14025	COG0101	tRNA pseudouridine synthase activity
GPY47_RS14035	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GPY47_RS14040	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPY47_RS14045	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPY47_RS14050	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPY47_RS14050	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GPY47_RS14055	COG0431	NADPH-dependent FMN reductase
GPY47_RS14070	COG3101	peptidyl-lysine hydroxylation
GPY47_RS14080	COG2860	membrane
GPY47_RS14085	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GPY47_RS14090	COG2890	protein-(glutamine-N5) methyltransferase activity
GPY47_RS14095	COG2840	Smr protein MutS2
GPY47_RS14100	COG2062	phosphohistidine phosphatase, SixA
GPY47_RS14115	COG1024	Enoyl-CoA hydratase
GPY47_RS14115	COG1250	3-hydroxyacyl-CoA dehydrogenase
GPY47_RS14120	COG0183	Belongs to the thiolase family
GPY47_RS14140	COG2067	long-chain fatty acid transport protein
GPY47_RS14150	COG3088	subunit of a heme lyase
GPY47_RS14150	COG4235	cytochrome complex assembly
GPY47_RS14160	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GPY47_RS14165	COG1138	Cytochrome C-type biogenesis protein
GPY47_RS14170	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
GPY47_RS14175	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPY47_RS14180	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPY47_RS14185	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPY47_RS14190	COG4133	protoheme IX ABC transporter activity
GPY47_RS14200	COG0835	chemotaxis
GPY47_RS14210	COG1192	Involved in chromosome partitioning
GPY47_RS14215	COG2201	protein-glutamate methylesterase activity
GPY47_RS14220	COG2198	Histidine kinase
GPY47_RS14220	COG0643	Histidine kinase
GPY47_RS14225	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
GPY47_RS14240	COG0455	bacterial-type flagellum organization
GPY47_RS14260	COG1684	flagellar biosynthetic protein fliR
GPY47_RS14265	COG1987	bacterial-type flagellum assembly
GPY47_RS14320	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GPY47_RS14330	COG1677	Flagellar hook-basal body complex protein FliE
GPY47_RS14335	COG2204	response regulator
GPY47_RS14340	COG4191	Histidine kinase
GPY47_RS14345	COG2204	response regulator
GPY47_RS14350	COG1516	flagellar protein fliS
GPY47_RS14360	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GPY47_RS14365	COG1334	flagellar protein FlaG
GPY47_RS14370	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY47_RS14375	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY47_RS14385	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY47_RS14390	COG2837	iron assimilation
GPY47_RS14415	COG1393	Belongs to the ArsC family
GPY47_RS14420	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPY47_RS14440	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GPY47_RS14450	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GPY47_RS14465	COG4783	chaperone-mediated protein folding
GPY47_RS14470	COG1393	Belongs to the ArsC family
GPY47_RS14490	COG2233	PERMEase
GPY47_RS14495	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GPY47_RS14500	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GPY47_RS14505	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GPY47_RS14510	COG0121	glutamine amidotransferase
GPY47_RS14515	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GPY47_RS14520	COG1960	acyl-CoA dehydrogenase activity
GPY47_RS14550	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GPY47_RS14555	COG0328	RNA-DNA hybrid ribonuclease activity
GPY47_RS14560	COG2226	methyltransferase
GPY47_RS14565	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPY47_RS14570	COG0741	lytic transglycosylase activity
GPY47_RS14570	COG1388	LysM domain
GPY47_RS14580	COG3021	interspecies interaction between organisms
GPY47_RS14585	COG0347	Belongs to the P(II) protein family
GPY47_RS14600	COG0825	malonyl-CoA metabolic process
GPY47_RS14605	COG0587	DNA-directed DNA polymerase activity
GPY47_RS14615	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY47_RS14620	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY47_RS14630	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPY47_RS14635	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
GPY47_RS14645	COG0750	zinc metalloprotease
GPY47_RS14650	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GPY47_RS14655	COG0575	Belongs to the CDS family
GPY47_RS14660	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GPY47_RS14665	COG0233	cytoplasmic translational termination
GPY47_RS14670	COG0528	UMP kinase activity
GPY47_RS14675	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GPY47_RS14680	COG0052	Belongs to the universal ribosomal protein uS2 family
GPY47_RS14685	COG0024	Methionine aminopeptidase
GPY47_RS14690	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GPY47_RS14705	COG0564	pseudouridine synthase activity
GPY47_RS14710	COG3098	single-species biofilm formation
GPY47_RS14740	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GPY47_RS14745	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GPY47_RS14770	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPY47_RS14780	COG0254	rRNA binding
GPY47_RS14785	COG1720	tRNA m6t6A37 methyltransferase activity
GPY47_RS14790	COG0442	prolyl-tRNA aminoacylation
GPY47_RS14810	COG0733	neurotransmitter:sodium symporter activity
GPY47_RS14830	COG0514	ATP-dependent DNA helicase (RecQ)
GPY47_RS14835	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GPY47_RS14845	COG0745	RESPONSE REGULATOR receiver
GPY47_RS14845	COG3706	GGDEF domain
GPY47_RS14855	COG1477	protein flavinylation
GPY47_RS14860	COG2871	sodium ion transport
GPY47_RS14865	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY47_RS14870	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY47_RS14875	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY47_RS14880	COG1805	sodium ion transport
GPY47_RS14885	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPY47_RS14890	COG0271	Belongs to the BolA IbaG family
GPY47_RS14895	COG2813	Specifically methylates the guanine in position
GPY47_RS14900	COG3056	Lipoprotein
GPY47_RS14920	COG1595	DNA-templated transcription, initiation
GPY47_RS14945	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GPY47_RS14950	COG0693	protein deglycase activity
GPY47_RS14955	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GPY47_RS14960	COG3706	GGDEF domain
GPY47_RS14965	COG2166	iron-sulfur cluster assembly
GPY47_RS14970	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GPY47_RS14975	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
GPY47_RS14985	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GPY47_RS14985	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GPY47_RS14995	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GPY47_RS15000	COG1074	ATP-dependent DNA helicase activity
GPY47_RS15005	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GPY47_RS15025	COG3141	response to X-ray
GPY47_RS15040	COG2171	N-acyltransferase activity
GPY47_RS15045	COG0584	glycerophosphoryl diester phosphodiesterase
GPY47_RS15050	COG2271	Major facilitator Superfamily
GPY47_RS15060	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GPY47_RS15065	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GPY47_RS15070	COG1349	DNA-binding transcription factor activity
GPY47_RS15075	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GPY47_RS15080	COG0598	Magnesium transport protein CorA
GPY47_RS15100	COG1609	Transcriptional regulator
GPY47_RS15105	COG0583	DNA-binding transcription factor activity
GPY47_RS15145	COG1022	Amp-dependent synthetase and ligase
GPY47_RS15155	COG0583	DNA-binding transcription factor activity
GPY47_RS15160	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPY47_RS15165	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GPY47_RS15175	COG0560	Phosphoserine phosphatase
GPY47_RS15185	COG0813	purine-nucleoside phosphorylase activity
GPY47_RS15190	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GPY47_RS15195	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GPY47_RS15200	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GPY47_RS15205	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPY47_RS15210	COG0084	hydrolase, TatD family'
GPY47_RS15240	COG3153	acetyltransferase
GPY47_RS15265	COG0534	Mate efflux family protein
GPY47_RS15280	COG1185	polyribonucleotide nucleotidyltransferase activity
GPY47_RS15285	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GPY47_RS15290	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GPY47_RS15295	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GPY47_RS15300	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GPY47_RS15305	COG0195	Participates in both transcription termination and antitermination
GPY47_RS15310	COG0779	Required for maturation of 30S ribosomal subunits
GPY47_RS15325	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GPY47_RS15335	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPY47_RS15340	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GPY47_RS15345	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GPY47_RS15350	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GPY47_RS15355	COG1534	Rna-binding protein
GPY47_RS15360	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY47_RS15365	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPY47_RS15370	COG2027	D-alanyl-D-alanine carboxypeptidase
GPY47_RS15380	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GPY47_RS15385	COG0739	heme binding
GPY47_RS15410	COG0628	permease
GPY47_RS15425	COG0747	negative chemotaxis
GPY47_RS15435	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY47_RS15440	COG0444	Belongs to the ABC transporter superfamily
GPY47_RS15445	COG4608	Belongs to the ABC transporter superfamily
GPY47_RS15455	COG2971	BadF BadG BcrA BcrD
GPY47_RS15470	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPY47_RS15475	COG3842	ATPase activity
GPY47_RS15485	COG1840	ABC-type Fe3 transport system, periplasmic component
GPY47_RS15490	COG0004	ammonium transporteR
GPY47_RS15500	COG3112	Uncharacterised protein family (UPF0231)
GPY47_RS15505	COG1049	propionate catabolic process, 2-methylcitrate cycle
GPY47_RS15510	COG1752	Esterase of the alpha-beta hydrolase superfamily
GPY47_RS15515	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GPY47_RS15520	COG1643	Atp-dependent helicase
GPY47_RS15525	COG1489	DNA binding
GPY47_RS15530	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GPY47_RS15535	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPY47_RS15545	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GPY47_RS15550	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GPY47_RS15555	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GPY47_RS15560	COG1560	Kdo2-lipid A biosynthetic process
GPY47_RS15565	COG0842	Transport permease protein
GPY47_RS15570	COG1131	(ABC) transporter
GPY47_RS15575	COG0659	secondary active sulfate transmembrane transporter activity
GPY47_RS15580	COG0288	reversible hydration of carbon dioxide
GPY47_RS15595	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY47_RS15600	COG0508	dehydrogenase complex catalyzes the overall conversion of
GPY47_RS15605	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GPY47_RS15610	COG2186	Transcriptional regulator
GPY47_RS15620	COG0157	Belongs to the NadC ModD family
GPY47_RS15630	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY47_RS15635	COG1459	type II secretion system
GPY47_RS15645	COG0237	dephospho-CoA kinase activity
GPY47_RS15650	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
GPY47_RS15655	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GPY47_RS15670	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GPY47_RS15675	COG0228	four-way junction DNA binding
GPY47_RS15680	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GPY47_RS15685	COG4137	Cytochrome C assembly protein
GPY47_RS15690	COG4536	flavin adenine dinucleotide binding
GPY47_RS15695	COG1854	S-ribosylhomocysteine lyase activity
GPY47_RS15710	COG0612	Peptidase, M16
GPY47_RS15715	COG1238	metal cluster binding
GPY47_RS15725	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GPY47_RS15730	COG0511	ligase activity, forming carbon-carbon bonds
GPY47_RS15730	COG5016	pyruvate
GPY47_RS15795	COG0527	aspartate kinase activity
GPY47_RS15800	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GPY47_RS15805	COG2137	regulation of response to DNA damage stimulus
GPY47_RS15815	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GPY47_RS15820	COG1546	Belongs to the CinA family
GPY47_RS15825	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GPY47_RS15830	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPY47_RS15840	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GPY47_RS15845	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GPY47_RS15855	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GPY47_RS15860	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GPY47_RS15865	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GPY47_RS15870	COG0148	phosphopyruvate hydratase activity
GPY47_RS15875	COG0504	CTP synthase activity
GPY47_RS15880	COG3956	TIGRFAM MazG family protein
GPY47_RS15885	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GPY47_RS15895	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPY47_RS15905	COG0736	holo-[acyl-carrier-protein] synthase activity
GPY47_RS15910	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GPY47_RS15915	COG1381	Involved in DNA repair and RecF pathway recombination
GPY47_RS15920	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GPY47_RS15930	COG0681	Belongs to the peptidase S26 family
GPY47_RS15935	COG0481	GTPase activity
GPY47_RS15940	COG3086	response to oxidative stress
GPY47_RS15955	COG1595	DNA-templated transcription, initiation
GPY47_RS15965	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GPY47_RS15975	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GPY47_RS15995	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPY47_RS16000	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPY47_RS16005	COG3079	Belongs to the UPF0149 family
GPY47_RS16015	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
GPY47_RS16025	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GPY47_RS16030	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GPY47_RS16035	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPY47_RS16045	COG0583	DNA-binding transcription factor activity
GPY47_RS16060	COG0668	transmembrane transport
GPY47_RS16065	COG0191	fructose-bisphosphate aldolase activity
GPY47_RS16080	COG4771	TonB-dependent receptor
GPY47_RS16085	COG0583	DNA-binding transcription factor activity
GPY47_RS16090	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GPY47_RS16100	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GPY47_RS16115	COG2356	endonuclease I
GPY47_RS16120	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GPY47_RS16125	COG0189	ligase activity
GPY47_RS16130	COG1678	Uncharacterized ACR, COG1678
GPY47_RS16135	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GPY47_RS16150	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GPY47_RS16155	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GPY47_RS16160	COG0762	integral membrane protein
GPY47_RS16165	COG1872	DUF167
GPY47_RS16175	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GPY47_RS16180	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GPY47_RS16185	COG2066	Belongs to the glutaminase family
GPY47_RS16195	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GPY47_RS16205	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
GPY47_RS16250	COG0840	transmembrane signaling receptor activity
GPY47_RS16325	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GPY47_RS16335	COG3394	polysaccharide catabolic process
GPY47_RS16340	COG1486	melibiose metabolic process
GPY47_RS16345	COG1447	Phosphotransferase system cellobiose-specific component IIA
GPY47_RS16350	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GPY47_RS16360	COG0726	polysaccharide deacetylase
GPY47_RS16405	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GPY47_RS16415	COG3706	GGDEF domain
GPY47_RS16415	COG0745	RESPONSE REGULATOR receiver
GPY47_RS16490	COG1028	Short-chain dehydrogenase reductase Sdr
GPY47_RS16495	COG4325	translation initiation factor activity
GPY47_RS16505	COG0795	lipopolysaccharide-transporting ATPase activity
GPY47_RS16510	COG0795	lipopolysaccharide-transporting ATPase activity
GPY47_RS16515	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GPY47_RS16520	COG2927	DNA polymerase III (CHI subunit)
GPY47_RS16525	COG0525	valine-tRNA ligase activity
GPY47_RS16535	COG0456	acetyltransferase
GPY47_RS16565	COG0540	Belongs to the ATCase OTCase family
GPY47_RS16570	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
GPY47_RS16575	COG0251	oxidation-reduction process
GPY47_RS16580	COG0204	Acyl-transferase
GPY47_RS16585	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GPY47_RS16590	COG5007	Belongs to the BolA IbaG family
GPY47_RS16600	COG2854	intermembrane phospholipid transfer
GPY47_RS16605	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GPY47_RS16610	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GPY47_RS16615	COG1127	ABC transporter
GPY47_RS16625	COG0517	IMP dehydrogenase activity
GPY47_RS16625	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GPY47_RS16635	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GPY47_RS16640	COG1137	ATPase activity
GPY47_RS16650	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GPY47_RS16655	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY47_RS16660	COG1660	Displays ATPase and GTPase activities
GPY47_RS16665	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY47_RS16670	COG2239	Acts as a magnesium transporter
GPY47_RS16680	COG0312	modulator of DNA gyrase
GPY47_RS16685	COG3028	Belongs to the UPF0307 family
GPY47_RS16690	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GPY47_RS16695	COG0564	pseudouridine synthase activity
GPY47_RS16705	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GPY47_RS16710	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GPY47_RS16715	COG0312	modulator of DNA gyrase
GPY47_RS16720	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GPY47_RS16725	COG3164	Protein of unknown function
GPY47_RS16730	COG1530	ribonuclease E activity
GPY47_RS16735	COG0424	maF-like protein
GPY47_RS16740	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GPY47_RS16745	COG1792	Involved in formation and maintenance of cell shape
GPY47_RS16750	COG1077	Cell shape determining protein MreB Mrl
GPY47_RS16795	COG1459	type II secretion system
GPY47_RS16800	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY47_RS16810	COG3267	Type II secretory pathway component ExeA
GPY47_RS16810	COG3409	Peptidoglycan-binding domain 1 protein
GPY47_RS16815	COG1450	Type ii and iii secretion system protein
GPY47_RS16835	COG2199	diguanylate cyclase activity
GPY47_RS16835	COG2200	EAL domain
GPY47_RS16840	COG0629	single-stranded DNA binding
GPY47_RS16855	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GPY47_RS16865	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GPY47_RS16870	COG0527	aspartate kinase activity
GPY47_RS16875	COG1410	methionine synthase
GPY47_RS16875	COG0646	methionine synthase
GPY47_RS16935	COG0175	sulfate reduction
GPY47_RS16940	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GPY47_RS16945	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GPY47_RS16965	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPY47_RS16970	COG0735	belongs to the Fur family
GPY47_RS16980	COG0166	Belongs to the GPI family
GPY47_RS16985	COG0432	Pfam Uncharacterised protein family UPF0047
GPY47_RS16990	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPY47_RS16995	COG0305	Participates in initiation and elongation during chromosome replication
GPY47_RS17015	COG2965	DNA replication, synthesis of RNA primer
GPY47_RS17020	COG0360	Binds together with S18 to 16S ribosomal RNA
GPY47_RS17025	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GPY47_RS17030	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GPY47_RS17040	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GPY47_RS17045	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GPY47_RS17075	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GPY47_RS17085	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPY47_RS17085	COG0678	peroxiredoxin activity
GPY47_RS17090	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY47_RS17100	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GPY47_RS17100	COG0165	Argininosuccinate lyase
GPY47_RS17105	COG0137	argininosuccinate synthase activity
GPY47_RS17115	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GPY47_RS17125	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GPY47_RS17135	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GPY47_RS17140	COG0460	homoserine dehydrogenase
GPY47_RS17140	COG0527	aspartate kinase activity
GPY47_RS17145	COG0626	cystathionine gamma-synthase activity
GPY47_RS17155	COG0281	malic enzyme
GPY47_RS17165	COG2906	2 iron, 2 sulfur cluster binding
GPY47_RS17170	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GPY47_RS17175	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPY47_RS17195	COG2923	Belongs to the DsrF TusC family
GPY47_RS17200	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GPY47_RS17205	COG2964	Protein conserved in bacteria
GPY47_RS17210	COG0545	Peptidyl-prolyl cis-trans isomerase
GPY47_RS17225	COG1446	asparaginase
GPY47_RS17235	COG1047	Peptidyl-prolyl cis-trans
GPY47_RS17250	COG2249	NAD(P)H dehydrogenase (quinone) activity
GPY47_RS17255	COG0488	(ABC) transporter
GPY47_RS17265	COG0429	hydrolase of the alpha beta-hydrolase fold
GPY47_RS17275	COG3954	Phosphoribulokinase
GPY47_RS17280	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPY47_RS17300	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GPY47_RS17305	COG0512	Glutamine amidotransferase of anthranilate synthase
GPY47_RS17320	COG0180	Tryptophanyl-tRNA synthetase
GPY47_RS17325	COG0546	phosphoglycolate phosphatase activity
GPY47_RS17330	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPY47_RS17335	COG0557	exoribonuclease II activity
GPY47_RS17340	COG1959	2 iron, 2 sulfur cluster binding
GPY47_RS17345	COG1017	nitric oxide dioxygenase activity
GPY47_RS17345	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPY47_RS17350	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
GPY47_RS17360	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GPY47_RS17365	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
GPY47_RS17370	COG0330	HflC and HflK could
GPY47_RS17375	COG0330	HflC and HflK could
GPY47_RS17380	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GPY47_RS17390	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GPY47_RS17395	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GPY47_RS17405	COG0802	atpase or kinase
GPY47_RS17410	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GPY47_RS17475	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GPY47_RS17480	COG1162	GTPase activity
GPY47_RS17485	COG0688	phosphatidylethanolamine metabolic process
GPY47_RS17490	COG0471	metal ion transport
GPY47_RS17490	COG3273	potassium ion transport
GPY47_RS17500	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GPY47_RS17505	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY47_RS17510	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GPY47_RS17515	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GPY47_RS17520	COG1045	serine acetyltransferase
GPY47_RS17525	COG4942	peptidase
GPY47_RS17545	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
GPY47_RS17550	COG1053	succinate dehydrogenase
GPY47_RS17555	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GPY47_RS17560	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GPY47_RS17565	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GPY47_RS17580	COG1509	lysine 2,3-aminomutase activity
GPY47_RS17585	COG1285	pathogenesis
GPY47_RS17595	COG0459	protein refolding
GPY47_RS17600	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GPY47_RS17605	COG0534	Mate efflux family protein
GPY47_RS17610	COG0205	6-phosphofructokinase activity
GPY47_RS17620	COG3678	ATP-independent chaperone mediated protein folding
GPY47_RS17625	COG0745	RESPONSE REGULATOR receiver
GPY47_RS17630	COG2205	protein histidine kinase activity
GPY47_RS17640	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GPY47_RS17645	COG3030	protein affecting phage T7 exclusion by the F plasmid
GPY47_RS17650	COG1027	Aspartate ammonia-lyase
GPY47_RS17655	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GPY47_RS17660	COG4232	protein-disulfide reductase activity
GPY47_RS17670	COG3263	regulation of cellular component size
GPY47_RS17680	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPY47_RS17705	COG2814	Major facilitator Superfamily
GPY47_RS17720	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPY47_RS17725	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GPY47_RS17730	COG0511	ligase activity, forming carbon-carbon bonds
GPY47_RS17735	COG0439	Biotin carboxylase
GPY47_RS17740	COG2264	protein methyltransferase activity
GPY47_RS17745	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPY47_RS17750	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GPY47_RS17760	COG0488	(ABC) transporter
GPY47_RS17810	COG1982	Orn Lys Arg decarboxylase major
GPY47_RS17815	COG0531	amino acid
GPY47_RS17825	COG3710	Transcriptional regulator
GPY47_RS17830	COG0789	Transcriptional regulator
GPY47_RS17845	COG0151	Belongs to the GarS family
GPY47_RS17860	COG1253	flavin adenine dinucleotide binding
GPY47_RS17865	COG3068	Protein conserved in bacteria
GPY47_RS17875	COG1573	uracil-dna glycosylase
GPY47_RS17880	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GPY47_RS17885	COG2816	NAD+ diphosphatase activity
GPY47_RS17890	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
GPY47_RS17895	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GPY47_RS17900	COG0085	RNA polymerase activity
GPY47_RS17905	COG0222	ribosome binding
GPY47_RS17910	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GPY47_RS17925	COG0250	Participates in transcription elongation, termination and antitermination
GPY47_RS17930	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GPY47_RS17940	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GPY47_RS17970	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
GPY47_RS17970	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
GPY47_RS17975	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GPY47_RS17985	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GPY47_RS18060	COG4206	TonB-dependent receptor
GPY47_RS18080	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY47_RS18085	COG0534	Mate efflux family protein
GPY47_RS18090	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
GPY47_RS18100	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GPY47_RS18105	COG2937	Belongs to the GPAT DAPAT family
GPY47_RS18110	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GPY47_RS18115	COG3161	chorismate lyase activity
GPY47_RS18120	COG1580	Controls the rotational direction of flagella during chemotaxis
GPY47_RS18125	COG0705	Rhomboid family
GPY47_RS18130	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY47_RS18140	COG2177	Part of the ABC transporter FtsEX involved in
GPY47_RS18145	COG2884	Cell division ATP-binding protein ftsE
GPY47_RS18150	COG0552	protein localization to endoplasmic reticulum
GPY47_RS18155	COG0742	ribosomal rna small subunit methyltransferase
GPY47_RS18165	COG2095	MarC family integral membrane protein
GPY47_RS18205	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPY47_RS18210	COG0640	Transcriptional regulator
GPY47_RS18215	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GPY47_RS18220	COG1280	lysine exporter protein (LysE YggA)
GPY47_RS18225	COG2267	carboxylic ester hydrolase activity
GPY47_RS18230	COG0561	phosphatase activity
GPY47_RS18250	COG2199	diguanylate cyclase activity
GPY47_RS18250	COG3287	FIST C domain
GPY47_RS18250	COG2200	EAL domain
GPY47_RS18255	COG1011	Hydrolase
GPY47_RS18260	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GPY47_RS18275	COG0019	diaminopimelate decarboxylase activity
GPY47_RS18285	COG1965	Belongs to the frataxin family
GPY47_RS18290	COG3072	Adenylate cyclase
GPY47_RS18295	COG0181	hydroxymethylbilane synthase activity
GPY47_RS18300	COG1587	Uroporphyrinogen-III synthase
GPY47_RS18305	COG2959	enzyme of heme biosynthesis
GPY47_RS18310	COG3071	HemY protein
GPY47_RS18355	COG0633	Ferredoxin
GPY47_RS18360	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GPY47_RS18370	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GPY47_RS18375	COG3118	belongs to the thioredoxin family
GPY47_RS18380	COG0513	Belongs to the DEAD box helicase family
GPY47_RS18385	COG0248	Ppx GppA phosphatase
GPY47_RS18395	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GPY47_RS18405	COG0514	ATP-dependent DNA helicase (RecQ)
GPY47_RS18410	COG2962	Rard protein
GPY47_RS18420	COG1280	lysine exporter protein (LysE YggA)
GPY47_RS18425	COG0405	Gamma-glutamyltransferase
GPY47_RS18435	COG0210	DNA helicase
GPY47_RS18445	COG3220	belongs to the UPF0276 family
GPY47_RS18475	COG0006	proline dipeptidase activity
GPY47_RS18475	COG0006	proline dipeptidase activity
GPY47_RS18490	COG2104	thiamine diphosphate biosynthetic process
GPY47_RS18495	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GPY47_RS18515	COG2132	Multicopper oxidase
GPY47_RS18565	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY47_RS18570	COG1739	Uncharacterized protein family UPF0029
GPY47_RS18580	COG0183	Belongs to the thiolase family
GPY47_RS18585	COG0604	alcohol dehydrogenase
GPY47_RS18600	COG0425	Belongs to the sulfur carrier protein TusA family
GPY47_RS18610	COG2119	membrane
GPY47_RS18625	COG0366	Alpha amylase catalytic
GPY47_RS18630	COG3977	Valine--pyruvate aminotransferase
GPY47_RS18635	COG0071	Belongs to the small heat shock protein (HSP20) family
GPY47_RS18650	COG0187	DNA topoisomerase II activity
GPY47_RS18660	COG0592	DNA-directed DNA polymerase activity
GPY47_RS18665	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GPY47_RS18685	COG1126	abc transporter atp-binding protein
GPY47_RS18695	COG0594	ribonuclease P activity
GPY47_RS18700	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GPY47_RS18705	COG0706	membrane insertase activity
GPY47_RS18715	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GPY47_RS18720	COG0445	tRNA wobble uridine modification
GPY47_RS18725	COG0357	Ribosomal RNA small subunit methyltransferase G
GPY47_RS18730	COG1192	Involved in chromosome partitioning
GPY47_RS18735	COG1475	DNA binding
GPY47_RS18740	COG3312	ion transport
GPY47_RS18745	COG0356	it plays a direct role in the translocation of protons across the membrane
GPY47_RS18755	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GPY47_RS18760	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GPY47_RS18765	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GPY47_RS18770	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GPY47_RS18775	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GPY47_RS18780	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GPY47_RS18790	COG0765	amino acid transport
GPY47_RS18800	COG2814	Major facilitator Superfamily
GPY47_RS18805	COG0583	DNA-binding transcription factor activity
GPY47_RS18815	COG0129	dihydroxy-acid dehydratase activity
GPY47_RS18820	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GPY47_RS18825	COG3978	acetolactate synthase activity
GPY47_RS18835	COG0606	chelatase, subunit chli
GPY47_RS18845	COG0204	Acyl-transferase
GPY47_RS18850	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPY47_RS18855	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GPY47_RS18865	COG3084	Protein conserved in bacteria
GPY47_RS18875	COG4326	sporulation control protein
GPY47_RS18880	COG1272	protein, Hemolysin III
GPY47_RS18890	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY47_RS18895	COG0569	domain protein
GPY47_RS18900	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GPY47_RS18900	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GPY47_RS18905	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GPY47_RS18910	COG0242	peptide deformylase activity
GPY47_RS18920	COG0758	DNA mediated transformation
GPY47_RS18925	COG2922	Belongs to the Smg family
GPY47_RS18930	COG0551	DNA topoisomerase type I activity
GPY47_RS18935	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GPY47_RS18940	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GPY47_RS18945	COG0009	L-threonylcarbamoyladenylate synthase
GPY47_RS18950	COG0408	coproporphyrinogen oxidase activity
GPY47_RS18965	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GPY47_RS19000	COG0583	DNA-binding transcription factor activity
GPY47_RS19005	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GPY47_RS19010	COG2960	long-chain fatty acid transporting porin activity
GPY47_RS19015	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY47_RS19020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY47_RS19075	COG4172	Belongs to the ABC transporter superfamily
GPY47_RS19080	COG4166	transmembrane transport
GPY47_RS19090	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPY47_RS19135	COG1609	Transcriptional regulator
GPY47_RS19140	COG0583	DNA-binding transcription factor activity
GPY47_RS19150	COG2076	Multidrug Resistance protein
GPY47_RS19155	COG0129	dihydroxy-acid dehydratase activity
GPY47_RS19160	COG3265	gluconokinase activity
GPY47_RS19165	COG2610	gluconate transmembrane transporter activity
GPY47_RS19170	COG0800	Aldolase
GPY47_RS19175	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GPY47_RS19180	COG0583	DNA-binding transcription factor activity
GPY47_RS19185	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPY47_RS19190	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GPY47_RS19200	COG1522	sequence-specific DNA binding
GPY47_RS19205	COG5001	Diguanylate cyclase
GPY47_RS19205	COG5002	protein histidine kinase activity
GPY47_RS19210	COG0742	ribosomal rna small subunit methyltransferase
GPY47_RS19220	COG0697	spore germination
GPY47_RS19225	COG0589	response to stress
GPY47_RS19230	COG1528	Iron-storage protein
GPY47_RS19240	COG2081	HI0933 family
GPY47_RS19270	COG1597	lipid kinase activity
GPY47_RS19300	COG0628	permease
GPY47_RS19315	COG1322	Protein conserved in bacteria
GPY47_RS19320	COG2226	methyltransferase
GPY47_RS19325	COG3165	ubiquinone biosynthetic process from chorismate
GPY47_RS19330	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GPY47_RS19345	COG0805	protein transport
GPY47_RS19360	COG0084	hydrolase, TatD family'
GPY47_RS19375	COG0456	acetyltransferase
GPY47_RS19385	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPY47_RS19385	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPY47_RS19390	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GPY47_RS19420	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GPY47_RS19425	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GPY47_RS19435	COG2204	response regulator
GPY47_RS19440	COG3852	Histidine kinase
GPY47_RS19450	COG0174	glutamine synthetase
GPY47_RS19460	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GPY47_RS19470	COG1295	ribonuclease BN
GPY47_RS19475	COG1490	D-aminoacyl-tRNA deacylase activity
GPY47_RS19480	COG0456	acetyltransferase
GPY47_RS19490	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GPY47_RS19495	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GPY47_RS19500	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GPY47_RS19505	COG3031	protein transport across the cell outer membrane
GPY47_RS19515	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPY47_RS19520	COG1459	type II secretion system
GPY47_RS19525	COG2165	general secretion pathway protein
GPY47_RS19530	COG2165	general secretion pathway protein
GPY47_RS19535	COG2165	general secretion pathway protein
GPY47_RS19540	COG4795	General secretion pathway protein
GPY47_RS19545	COG3156	type II secretion system protein K
GPY47_RS19550	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GPY47_RS19555	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GPY47_RS19565	COG1218	3'(2'),5'-bisphosphate nucleotidase
GPY47_RS19570	COG0494	nUDIX hydrolase
GPY47_RS19580	COG1040	competence protein
GPY47_RS19595	COG2183	response to ionizing radiation
GPY47_RS19605	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPY47_RS19615	COG0745	RESPONSE REGULATOR receiver
GPY47_RS19620	COG2205	protein histidine kinase activity
GPY47_RS19625	COG2233	PERMEase
GPY47_RS19630	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GPY47_RS19635	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPY47_RS19640	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GPY47_RS19645	COG1758	RNA polymerase activity
GPY47_RS19650	COG0194	GDP metabolic process
GPY47_RS19665	COG0848	biopolymer transport protein
GPY47_RS19670	COG0811	peptide transport
GPY47_RS19695	COG4174	ABC transporter (Permease)
GPY47_RS19700	COG4239	(ABC) transporter, permease
GPY47_RS19705	COG0747	negative chemotaxis
GPY47_RS19710	COG0444	Belongs to the ABC transporter superfamily
GPY47_RS19715	COG4608	Belongs to the ABC transporter superfamily
GPY47_RS19725	COG1561	YicC-like family, N-terminal region
GPY47_RS19730	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GPY47_RS19740	COG1560	Kdo2-lipid A biosynthetic process
GPY47_RS19745	COG1309	transcriptional regulator
GPY47_RS19750	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GPY47_RS19760	COG2003	Belongs to the UPF0758 family
GPY47_RS19785	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GPY47_RS19800	COG0463	Glycosyl transferase, family 2
GPY47_RS19805	COG0859	PFAM glycosyl transferase family 9
GPY47_RS19810	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GPY47_RS19815	COG3642	lipopolysaccharide core region biosynthetic process
GPY47_RS19825	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GPY47_RS19865	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GPY47_RS19870	COG1519	Transferase
GPY47_RS19875	COG0859	PFAM glycosyl transferase family 9
GPY47_RS19885	COG1560	Kdo2-lipid A biosynthetic process
GPY47_RS19895	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY47_RS19940	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GPY47_RS19945	COG0438	transferase activity, transferring glycosyl groups
GPY47_RS19965	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GPY47_RS19970	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GPY47_RS19975	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GPY47_RS20000	COG0438	transferase activity, transferring glycosyl groups
GPY47_RS20010	COG0438	transferase activity, transferring glycosyl groups
GPY47_RS20015	COG0438	transferase activity, transferring glycosyl groups
GPY47_RS20020	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GPY47_RS20030	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GPY47_RS20050	COG0149	triose-phosphate isomerase activity
GPY47_RS20080	COG1494	fructose-1,6-bisphosphatase
GPY47_RS20090	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GPY47_RS20095	COG1575	Belongs to the MenA family. Type 1 subfamily
GPY47_RS20100	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GPY47_RS20105	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GPY47_RS20115	COG1609	Transcriptional regulator
GPY47_RS20120	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GPY47_RS20130	COG0254	rRNA binding
GPY47_RS20140	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GPY47_RS20145	COG0088	Forms part of the polypeptide exit tunnel
GPY47_RS20155	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GPY47_RS20160	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GPY47_RS20165	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GPY47_RS20170	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GPY47_RS20180	COG0255	Belongs to the universal ribosomal protein uL29 family
GPY47_RS20185	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GPY47_RS20195	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GPY47_RS20200	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GPY47_RS20210	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GPY47_RS20215	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GPY47_RS20230	COG1841	ribosomal large subunit assembly
GPY47_RS20240	COG0201	protein transport
GPY47_RS20250	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GPY47_RS20255	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GPY47_RS20265	COG0202	RNA polymerase activity
GPY47_RS20270	COG0203	ribosomal protein L17
GPY47_RS20280	COG0545	Peptidyl-prolyl cis-trans isomerase
GPY47_RS20290	COG2153	protein acetylation
GPY47_RS20295	COG0513	Belongs to the DEAD box helicase family
GPY47_RS20310	COG1648	precorrin-2 dehydrogenase activity
GPY47_RS20310	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GPY47_RS20315	COG0175	sulfate reduction
GPY47_RS20320	COG2895	sulfate adenylyltransferase (ATP) activity
GPY47_RS20325	COG0471	metal ion transport
GPY47_RS20325	COG3273	potassium ion transport
GPY47_RS20330	COG0529	Catalyzes the synthesis of activated sulfate
GPY47_RS20350	COG4181	ATPase activity
GPY47_RS20365	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
GPY47_RS20375	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPY47_RS20380	COG0729	surface antigen
GPY47_RS20385	COG2911	Protein conserved in bacteria
GPY47_RS20390	COG2105	PFAM AIG2 family protein
GPY47_RS20400	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GPY47_RS20405	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GPY47_RS20415	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GPY47_RS20420	COG0163	prenyltransferase activity
GPY47_RS20425	COG4143	(ABC) transporter
GPY47_RS20430	COG1178	ABC-type Fe3 transport system permease component
GPY47_RS20435	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
GPY47_RS20440	COG0583	DNA-binding transcription factor activity
GPY47_RS20445	COG1902	pentaerythritol trinitrate reductase activity
GPY47_RS20485	COG0142	geranyltranstransferase activity
GPY47_RS20490	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GPY47_RS20500	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GPY47_RS20505	COG2966	Psort location CytoplasmicMembrane, score
GPY47_RS20515	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GPY47_RS20520	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GPY47_RS20525	COG2967	ApaG domain
GPY47_RS20530	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GPY47_RS20535	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GPY47_RS20540	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPY47_RS20545	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GPY47_RS20550	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GPY47_RS20570	COG0473	3-isopropylmalate dehydrogenase activity
GPY47_RS20575	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GPY47_RS20600	COG0583	DNA-binding transcription factor activity
GPY47_RS20605	COG1022	Amp-dependent synthetase and ligase
GPY47_RS20610	COG0028	Belongs to the TPP enzyme family
GPY47_RS20615	COG0440	acetolactate synthase activity
GPY47_RS20620	COG3706	GGDEF domain
GPY47_RS20630	COG0469	pyruvate kinase activity
GPY47_RS20635	COG1349	DNA-binding transcription factor activity
GPY47_RS20640	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GPY47_RS20650	COG2376	Dihydroxyacetone kinase
GPY47_RS20655	COG1461	Dihydroxyacetone kinase
GPY47_RS20670	COG3722	fumarate hydratase activity
GPY47_RS20680	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY47_RS20680	COG2213	PTS system mannitol-specific
GPY47_RS20710	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPY47_RS20715	COG0358	DNA primase activity
GPY47_RS20720	COG1610	YqeY-like protein
GPY47_RS20725	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GPY47_RS20730	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GPY47_RS20735	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GPY47_RS20740	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GPY47_RS20745	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GPY47_RS20750	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GPY47_RS20755	COG1968	undecaprenyl-diphosphatase activity
GPY47_RS20765	COG3409	Peptidoglycan-binding domain 1 protein
GPY47_RS20765	COG3267	Type II secretory pathway component ExeA
GPY47_RS20775	COG0405	Gamma-glutamyltransferase
GPY47_RS20780	COG4991	sh3 domain protein
GPY47_RS20785	COG0306	phosphate transporter
GPY47_RS20790	COG1392	Phosphate transport regulator
GPY47_RS20795	COG3025	triphosphatase activity
GPY47_RS20810	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GPY47_RS20815	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GPY47_RS20815	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GPY47_RS20820	COG1538	Outer membrane efflux protein
GPY47_RS20825	COG0494	nUDIX hydrolase
GPY47_RS20830	COG3151	Protein conserved in bacteria
GPY47_RS20840	COG3150	esterase
GPY47_RS20845	COG0187	DNA topoisomerase II activity
GPY47_RS20850	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GPY47_RS20855	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GPY47_RS20865	COG3105	Protein conserved in bacteria
GPY47_RS20875	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GPY47_RS20890	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GPY47_RS20895	COG0723	plastoquinol--plastocyanin reductase activity
GPY47_RS20900	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GPY47_RS20905	COG2857	Cytochrome c1
GPY47_RS20910	COG0625	glutathione transferase activity
GPY47_RS20915	COG2969	positive regulation of protein catabolic process
GPY47_RS20925	COG2823	Periplasmic or secreted lipoprotein
GPY47_RS20930	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GPY47_RS20945	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GPY47_RS20965	COG3116	cell division
GPY47_RS20970	COG0768	penicillin binding
GPY47_RS20975	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GPY47_RS20980	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GPY47_RS20985	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GPY47_RS20990	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GPY47_RS20995	COG0772	Belongs to the SEDS family
GPY47_RS21010	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GPY47_RS21015	COG0849	cell division
GPY47_RS21020	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GPY47_RS21025	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GPY47_RS21035	COG0653	protein targeting
GPY47_RS21040	COG0494	nUDIX hydrolase
GPY47_RS21050	COG0505	Belongs to the CarA family
GPY47_RS21055	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GPY47_RS21070	COG0730	response to heat
GPY47_RS21075	COG0583	DNA-binding transcription factor activity
GPY47_RS21080	COG2860	membrane
GPY47_RS21095	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GPY47_RS21105	COG0493	'glutamate synthase
GPY47_RS21110	COG0067	glutamate synthase
GPY47_RS21110	COG0069	glutamate synthase activity
GPY47_RS21110	COG0070	glutamate synthase
GPY47_RS21120	COG0067	glutamate synthase
GPY47_RS21120	COG0069	glutamate synthase activity
GPY47_RS21120	COG0070	glutamate synthase
GPY47_RS21125	COG1242	4 iron, 4 sulfur cluster binding
GPY47_RS21130	COG2203	Gaf domain
GPY47_RS21130	COG3706	GGDEF domain
GPY47_RS21130	COG4251	negative regulation of phosphorylation
GPY47_RS21130	COG5001	Diguanylate cyclase
GPY47_RS21135	COG5002	protein histidine kinase activity
GPY47_RS21135	COG0784	Response regulator, receiver
GPY47_RS21135	COG2198	Histidine kinase
GPY47_RS21145	COG0745	RESPONSE REGULATOR receiver
GPY47_RS21160	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GPY47_RS21180	COG0083	homoserine kinase activity
GPY47_RS21185	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GPY47_RS21195	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
GPY47_RS21200	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GPY47_RS21210	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GPY47_RS21225	COG1115	amino acid carrier protein
GPY47_RS21230	COG3022	response to hydroperoxide
GPY47_RS21235	COG0513	Belongs to the DEAD box helicase family
GPY47_RS21240	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GPY47_RS21250	COG0716	FMN binding
GPY47_RS21260	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPY47_RS21265	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GPY47_RS21280	COG2204	response regulator
GPY47_RS21295	COG0667	Aldo Keto reductase
GPY47_RS21325	COG0730	response to heat
GPY47_RS21335	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GPY47_RS21345	COG1283	sodium-dependent phosphate transmembrane transporter activity
GPY47_RS21350	COG0583	DNA-binding transcription factor activity
GPY47_RS21355	COG0640	Transcriptional regulator
GPY47_RS21360	COG0268	Binds directly to 16S ribosomal RNA
GPY47_RS21365	COG0728	peptidoglycan biosynthetic process
GPY47_RS21370	COG0196	riboflavin kinase activity
GPY47_RS21385	COG1047	Peptidyl-prolyl cis-trans
GPY47_RS21390	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GPY47_RS21400	COG3279	Response regulator of the LytR AlgR family
GPY47_RS21405	COG3275	phosphorelay sensor kinase activity
GPY47_RS21410	COG1966	Carbon starvation protein
GPY47_RS21430	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GPY47_RS21435	COG1472	Belongs to the glycosyl hydrolase 3 family
GPY47_RS21440	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPY47_RS21445	COG1605	Chorismate mutase
GPY47_RS21445	COG0287	Prephenate dehydrogenase
GPY47_RS21450	COG0739	heme binding
GPY47_RS21460	COG0488	(ABC) transporter
GPY47_RS21470	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
GPY47_RS21475	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
GPY47_RS21480	COG0077	Prephenate dehydratase
GPY47_RS21480	COG1605	Chorismate mutase
GPY47_RS21485	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GPY47_RS21495	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY47_RS21500	COG0564	pseudouridine synthase activity
GPY47_RS21510	COG0542	response to heat
GPY47_RS21570	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GPY47_RS21580	COG2974	May be involved in recombination
GPY47_RS21585	COG0745	RESPONSE REGULATOR receiver
GPY47_RS21590	COG5002	protein histidine kinase activity
GPY47_RS21600	COG0248	Ppx GppA phosphatase
GPY47_RS21605	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GPY47_RS21610	COG0573	inorganic phosphate transmembrane transporter activity
GPY47_RS21615	COG0581	inorganic phosphate transmembrane transporter activity
GPY47_RS21620	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GPY47_RS21625	COG0704	Plays a role in the regulation of phosphate uptake
GPY47_RS21635	COG3142	Participates in the control of copper homeostasis
GPY47_RS21640	COG0450	alkyl hydroperoxide reductase
GPY47_RS21645	COG0583	DNA-binding transcription factor activity
GPY47_RS21655	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GPY47_RS21665	COG0517	IMP dehydrogenase activity
GPY47_RS21675	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GPY47_RS21685	COG1862	Preprotein translocase
GPY47_RS21690	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY47_RS21695	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPY47_RS21700	COG0483	inositol monophosphate 1-phosphatase activity
GPY47_RS21705	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
GPY47_RS21715	COG1104	cysteine desulfurase activity
GPY47_RS21720	COG0822	iron-sulfur transferase activity
GPY47_RS21735	COG0443	Heat shock 70 kDa protein
GPY47_RS21740	COG0633	Ferredoxin
GPY47_RS21745	COG2975	iron-sulfur cluster assembly
GPY47_RS21755	COG0105	UTP biosynthetic process
GPY47_RS21770	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GPY47_RS21775	COG0124	histidyl-tRNA synthetase
GPY47_RS21780	COG2976	Protein conserved in bacteria
GPY47_RS21785	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY47_RS21790	COG1160	GTP binding
GPY47_RS21810	COG0517	IMP dehydrogenase activity
GPY47_RS21810	COG0516	GMP reductase activity
GPY47_RS21815	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GPY47_RS21815	COG0519	Catalyzes the synthesis of GMP from XMP
GPY47_RS21820	COG1757	Na H antiporter
GPY47_RS21830	COG1584	GPR1 FUN34 yaaH family protein
GPY47_RS21835	COG1115	amino acid carrier protein
GPY47_RS21850	COG2873	o-acetylhomoserine
GPY47_RS21855	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GPY47_RS21875	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GPY47_RS21875	COG3153	acetyltransferase
GPY47_RS21880	COG0583	DNA-binding transcription factor activity
GPY47_RS21900	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GPY47_RS21905	COG2867	negative regulation of translational initiation
GPY47_RS21910	COG2914	Belongs to the UPF0125 (RnfH) family
GPY47_RS21915	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPY47_RS21925	COG0497	DNA recombination
GPY47_RS21935	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GPY47_RS21940	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GPY47_RS21945	COG1301	dicarboxylic acid transport
GPY47_RS21955	COG0484	heat shock protein binding
GPY47_RS21990	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPY47_RS21995	COG0590	tRNA wobble adenosine to inosine editing
GPY47_RS22005	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GPY47_RS22010	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GPY47_RS22010	COG0047	phosphoribosylformylglycinamidine synthase activity
GPY47_RS22040	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPY47_RS22045	COG2252	PERMEase
GPY47_RS22050	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
GPY47_RS22065	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GPY47_RS22070	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GPY47_RS22075	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GPY47_RS22080	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPY47_RS22080	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPY47_RS22105	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GPY47_RS22110	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GPY47_RS22115	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GPY47_RS22120	COG0142	geranyltranstransferase activity
GPY47_RS22125	COG1722	exodeoxyribonuclease VII activity
GPY47_RS22130	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GPY47_RS22140	COG0301	tRNA thio-modification
GPY47_RS22140	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPY47_RS22145	COG0583	DNA-binding transcription factor activity
GPY47_RS22155	COG2363	Small membrane protein
GPY47_RS22165	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPY47_RS22170	COG1611	Belongs to the LOG family
GPY47_RS22175	COG0745	RESPONSE REGULATOR receiver
GPY47_RS22175	COG3706	GGDEF domain
GPY47_RS22185	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GPY47_RS22185	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GPY47_RS22195	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
GPY47_RS22200	COG1464	Belongs to the NlpA lipoprotein family
GPY47_RS22205	COG2011	ABC-type metal ion transport system permease component
GPY47_RS22210	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GPY47_RS22215	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GPY47_RS22225	COG1263	PTS System
GPY47_RS22225	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY47_RS22230	COG0366	Alpha amylase catalytic
GPY47_RS22245	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GPY47_RS22250	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GPY47_RS22255	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GPY47_RS22260	COG0321	lipoyl(octanoyl) transferase activity
GPY47_RS22270	COG1686	Belongs to the peptidase S11 family
GPY47_RS22275	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GPY47_RS22280	COG0772	Belongs to the SEDS family
GPY47_RS22285	COG0768	penicillin binding
GPY47_RS22290	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GPY47_RS22295	COG0799	negative regulation of ribosome biogenesis
GPY47_RS22300	COG1466	dna polymerase III delta subunit
GPY47_RS22305	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
GPY47_RS22310	COG0495	leucyl-tRNA aminoacylation
GPY47_RS22315	COG2888	peptidyl-tyrosine sulfation
GPY47_RS22320	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GPY47_RS22325	COG4535	Mg2 and Co2 transporter CorC
GPY47_RS22330	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GPY47_RS22335	COG1702	phosphate starvation-inducible protein PhoH
GPY47_RS22340	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GPY47_RS22350	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPY47_RS22460	COG0012	GTP binding
GPY47_RS22465	COG0193	aminoacyl-tRNA hydrolase activity
GPY47_RS22470	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GPY47_RS22475	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GPY47_RS22480	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
GPY47_RS22485	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GPY47_RS22495	COG2890	protein-(glutamine-N5) methyltransferase activity
GPY47_RS22500	COG3094	Invasion gene expression up-regulator, SirB
GPY47_RS22505	COG2912	Transglutaminase-like superfamily
GPY47_RS22510	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GPY47_RS22515	COG0737	Belongs to the 5'-nucleotidase family
GPY47_RS22520	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GPY47_RS22525	COG1187	pseudouridine synthase activity
GPY47_RS22530	COG2840	Smr protein MutS2
GPY47_RS22570	COG2608	mercury ion transmembrane transporter activity
GPY47_RS22570	COG2217	Heavy metal translocating P-type atpase
GPY47_RS22585	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GPY47_RS22640	COG0784	Response regulator, receiver
GPY47_RS22640	COG0835	chemotaxis
GPY47_RS22645	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GPY47_RS22650	COG1815	bacterial-type flagellum-dependent cell motility
GPY47_RS22655	COG1558	bacterial-type flagellum-dependent cell motility
GPY47_RS22660	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GPY47_RS22665	COG1749	Flagellar hook protein flgE
GPY47_RS22670	COG4787	bacterial-type flagellum-dependent cell motility
GPY47_RS22675	COG4786	Flagellar basal body rod
GPY47_RS22680	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GPY47_RS22685	COG1706	bacterial-type flagellum-dependent cell motility
GPY47_RS22690	COG1705	Flagellar rod assembly protein muramidase FlgJ
GPY47_RS22690	COG3951	Flagellar rod assembly protein muramidase FlgJ
GPY47_RS22700	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY47_RS22705	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY47_RS22710	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY47_RS22715	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPY47_RS22720	COG2190	(PTS) system
GPY47_RS22725	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GPY47_RS22730	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPY47_RS22740	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GPY47_RS22745	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
GPY47_RS22750	COG3115	cell septum assembly
GPY47_RS22755	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GPY47_RS22770	COG0330	HflC and HflK could
GPY47_RS22775	COG3118	belongs to the thioredoxin family
GPY47_RS22785	COG0300	oxidoreductase activity
GPY47_RS22790	COG1090	epimerase
GPY47_RS22820	COG0622	Phosphoesterase
GPY47_RS22840	COG3710	Transcriptional regulator
GPY47_RS22845	COG0326	Molecular chaperone. Has ATPase activity
GPY47_RS22855	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GPY47_RS22860	COG3104	oligopeptide transport
GPY47_RS22865	COG0250	Participates in transcription elongation, termination and antitermination
GPY47_RS22870	COG0367	asparagine synthase
GPY47_RS22875	COG4651	solute:proton antiporter activity
GPY47_RS22875	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GPY47_RS22880	COG1940	carbohydrate kinase activity
GPY47_RS22880	COG1846	Transcriptional regulator
GPY47_RS22885	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GPY47_RS22895	COG1263	PTS System
GPY47_RS22895	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPY47_RS22895	COG2190	(PTS) system
GPY47_RS22900	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPY47_RS22905	COG0735	belongs to the Fur family
GPY47_RS22915	COG0716	FMN binding
GPY47_RS22925	COG0596	Alpha beta hydrolase
GPY47_RS22930	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
GPY47_RS22935	COG0033	Phosphoglucomutase
GPY47_RS22945	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GPY47_RS22955	COG2009	succinate dehydrogenase
GPY47_RS22960	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GPY47_RS22965	COG1053	succinate dehydrogenase
GPY47_RS22970	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GPY47_RS22975	COG0567	Dehydrogenase, E1 component
GPY47_RS22980	COG0508	dehydrogenase complex catalyzes the overall conversion of
GPY47_RS22985	COG0045	succinate-CoA ligase (ADP-forming) activity
GPY47_RS22995	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GPY47_RS23000	COG1121	(ABC) transporter
GPY47_RS23005	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
GPY47_RS23010	COG4977	sequence-specific DNA binding
GPY47_RS23015	COG1918	ferrous iron import across plasma membrane
GPY47_RS23040	COG0018	arginyl-trna synthetase
GPY47_RS23050	COG3102	Protein conserved in bacteria
GPY47_RS23065	COG0788	formyltetrahydrofolate deformylase activity
GPY47_RS23070	COG1199	ATP-dependent helicase activity
GPY47_RS23075	COG1214	PFAM Peptidase M22, glycoprotease
GPY47_RS23085	COG3065	identical protein binding
GPY47_RS23090	COG2267	carboxylic ester hydrolase activity
GPY47_RS23095	COG0318	PFAM AMP-dependent synthetase and ligase
GPY47_RS23100	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GPY47_RS23110	COG2894	cell division
GPY47_RS23115	COG0850	regulation of cytokinetic process
GPY47_RS23120	COG3100	YcgL domain-containing protein
GPY47_RS23125	COG2951	lytic endotransglycosylase activity
GPY47_RS23135	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPY47_RS23140	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GPY47_RS23150	COG2226	methyltransferase
GPY47_RS23160	COG1028	Short-chain dehydrogenase reductase Sdr
GPY47_RS23165	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPY47_RS23170	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPY47_RS23195	COG2986	histidine ammonia-lyase
GPY47_RS23200	COG1216	Glycosyl transferase, family 2
GPY47_RS23205	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPY47_RS23220	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GPY47_RS23225	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GPY47_RS23260	COG0513	Belongs to the DEAD box helicase family
GPY47_RS23265	COG0569	domain protein
GPY47_RS23270	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPY47_RS23285	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GPY47_RS23290	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GPY47_RS23295	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GPY47_RS23300	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GPY47_RS23315	COG0544	peptidyl-prolyl cis-trans isomerase activity
GPY47_RS23325	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GPY47_RS23330	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GPY47_RS23335	COG0776	regulation of translation
GPY47_RS23340	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPY47_RS23345	COG1555	photosystem II stabilization
GPY47_RS23360	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GPY47_RS23365	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
GPY47_RS23370	COG0436	Aminotransferase
GPY47_RS23375	COG1169	isochorismate synthase
GPY47_RS23380	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GPY47_RS23390	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GPY47_RS23395	COG1441	menaquinone biosynthetic process
GPY47_RS23410	COG2855	membrane
GPY47_RS23415	COG0477	Major facilitator Superfamily
GPY47_RS23460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPY47_RS23465	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPY47_RS23480	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GPY47_RS23485	COG1522	sequence-specific DNA binding
GPY47_RS23495	COG1946	Acyl-CoA thioesterase
GPY47_RS23500	COG3126	Type III secretion system lipoprotein chaperone (YscW)
GPY47_RS23515	COG3706	GGDEF domain
GPY47_RS23525	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPY47_RS23530	COG0517	IMP dehydrogenase activity
GPY47_RS23530	COG0516	GMP reductase activity
GPY47_RS23555	COG0537	adenosine 5'-monophosphoramidase activity
GPY47_RS23580	COG3150	esterase
GPY47_RS23585	COG1252	NADH dehydrogenase
GPY47_RS23600	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GPY47_RS23695	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
GPY47_RS23700	COG1454	alcohol dehydrogenase
GPY47_RS23720	COG1063	alcohol dehydrogenase
GPY47_RS23725	COG3344	reverse transcriptase
GPY47_RS23745	COG0247	lactate metabolic process
GPY47_RS23750	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
GPY47_RS23755	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GPY47_RS23775	COG2909	trisaccharide binding
GPY47_RS23815	COG3118	belongs to the thioredoxin family
GPY47_RS23940	COG0529	Catalyzes the synthesis of activated sulfate
GPY47_RS23970	COG2199	diguanylate cyclase activity
GPY47_RS23980	COG3547	Transposase (IS116 IS110 IS902 family)
GPY47_RS23990	COG1278	Cold shock
GPY47_RS24000	COG0330	HflC and HflK could
GPY47_RS24020	COG1278	Cold shock
GPY47_RS24030	COG3547	Transposase (IS116 IS110 IS902 family)
GPY47_RS24065	COG3706	GGDEF domain
GPY47_RS24065	COG0745	RESPONSE REGULATOR receiver
GPY47_RS24145	COG1278	Cold shock
GPY47_RS24200	COG2337	Toxic component of a toxin-antitoxin (TA) module
GPY47_RS24240	COG0776	regulation of translation
GPY47_RS24270	COG0629	single-stranded DNA binding
GPY47_RS24330	COG0675	Transposase, IS605 OrfB family
GPY47_RS24350	COG1192	Involved in chromosome partitioning