locus-tag	class	description
FR729_RS00020	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FR729_RS00035	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
FR729_RS00045	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FR729_RS00075	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FR729_RS00090	COG3550	peptidyl-serine autophosphorylation
FR729_RS00140	COG3550	peptidyl-serine autophosphorylation
FR729_RS00230	COG0582	viral genome integration into host DNA
FR729_RS00295	COG0358	DNA primase activity
FR729_RS00300	COG1610	YqeY-like protein
FR729_RS00305	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FR729_RS00310	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FR729_RS00315	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FR729_RS00320	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
FR729_RS00325	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FR729_RS00330	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FR729_RS00335	COG1968	undecaprenyl-diphosphatase activity
FR729_RS00345	COG3267	Type II secretory pathway component ExeA
FR729_RS00345	COG3409	Peptidoglycan-binding domain 1 protein
FR729_RS00355	COG0405	Gamma-glutamyltransferase
FR729_RS00360	COG4991	sh3 domain protein
FR729_RS00365	COG0306	phosphate transporter
FR729_RS00370	COG1392	Phosphate transport regulator
FR729_RS00375	COG3025	triphosphatase activity
FR729_RS00390	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
FR729_RS00395	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FR729_RS00395	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
FR729_RS00400	COG1538	Outer membrane efflux protein
FR729_RS00405	COG0494	nUDIX hydrolase
FR729_RS00410	COG3151	Protein conserved in bacteria
FR729_RS00420	COG3150	esterase
FR729_RS00430	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FR729_RS00435	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FR729_RS00445	COG3105	Protein conserved in bacteria
FR729_RS00450	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
FR729_RS00460	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FR729_RS00465	COG0723	plastoquinol--plastocyanin reductase activity
FR729_RS00470	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FR729_RS00475	COG2857	Cytochrome c1
FR729_RS00480	COG0625	glutathione transferase activity
FR729_RS00485	COG2969	positive regulation of protein catabolic process
FR729_RS00490	COG2823	Periplasmic or secreted lipoprotein
FR729_RS00495	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
FR729_RS00510	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FR729_RS00525	COG3116	cell division
FR729_RS00530	COG0768	penicillin binding
FR729_RS00535	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FR729_RS00540	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FR729_RS00545	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FR729_RS00550	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FR729_RS00555	COG0772	Belongs to the SEDS family
FR729_RS00570	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FR729_RS00575	COG0849	cell division
FR729_RS00580	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FR729_RS00585	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
FR729_RS00595	COG0653	protein targeting
FR729_RS00600	COG0494	nUDIX hydrolase
FR729_RS00610	COG0505	Belongs to the CarA family
FR729_RS00615	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FR729_RS00630	COG0730	response to heat
FR729_RS00635	COG0583	DNA-binding transcription factor activity
FR729_RS00640	COG2860	membrane
FR729_RS00655	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FR729_RS00665	COG0493	'glutamate synthase
FR729_RS00670	COG0067	glutamate synthase
FR729_RS00670	COG0069	glutamate synthase activity
FR729_RS00670	COG0070	glutamate synthase
FR729_RS00680	COG0070	glutamate synthase
FR729_RS00680	COG0069	glutamate synthase activity
FR729_RS00680	COG0067	glutamate synthase
FR729_RS00685	COG1242	4 iron, 4 sulfur cluster binding
FR729_RS00690	COG3706	GGDEF domain
FR729_RS00690	COG2203	Gaf domain
FR729_RS00690	COG4251	negative regulation of phosphorylation
FR729_RS00690	COG5001	Diguanylate cyclase
FR729_RS00695	COG0784	Response regulator, receiver
FR729_RS00695	COG5002	protein histidine kinase activity
FR729_RS00695	COG2198	Histidine kinase
FR729_RS00705	COG0745	RESPONSE REGULATOR receiver
FR729_RS00715	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FR729_RS00735	COG0083	homoserine kinase activity
FR729_RS00740	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FR729_RS00750	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
FR729_RS00755	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
FR729_RS00760	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FR729_RS00775	COG1115	amino acid carrier protein
FR729_RS00780	COG3022	response to hydroperoxide
FR729_RS00785	COG0513	Belongs to the DEAD box helicase family
FR729_RS00790	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
FR729_RS00800	COG0716	FMN binding
FR729_RS00805	COG4974	Belongs to the 'phage' integrase family
FR729_RS00810	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FR729_RS00815	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FR729_RS00830	COG2204	response regulator
FR729_RS00840	COG0667	Aldo Keto reductase
FR729_RS00865	COG0730	response to heat
FR729_RS00875	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FR729_RS00885	COG1283	sodium-dependent phosphate transmembrane transporter activity
FR729_RS00890	COG0583	DNA-binding transcription factor activity
FR729_RS00895	COG0640	Transcriptional regulator
FR729_RS00900	COG0268	Binds directly to 16S ribosomal RNA
FR729_RS00905	COG0728	peptidoglycan biosynthetic process
FR729_RS00910	COG0196	riboflavin kinase activity
FR729_RS00925	COG1047	Peptidyl-prolyl cis-trans
FR729_RS00930	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FR729_RS00940	COG3279	Response regulator of the LytR AlgR family
FR729_RS00945	COG3275	phosphorelay sensor kinase activity
FR729_RS00950	COG1966	Carbon starvation protein
FR729_RS00970	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
FR729_RS00975	COG1472	Belongs to the glycosyl hydrolase 3 family
FR729_RS00980	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FR729_RS00985	COG1605	Chorismate mutase
FR729_RS00985	COG0287	Prephenate dehydrogenase
FR729_RS00990	COG0739	heme binding
FR729_RS01000	COG0488	(ABC) transporter
FR729_RS01010	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
FR729_RS01015	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
FR729_RS01020	COG0077	Prephenate dehydratase
FR729_RS01020	COG1605	Chorismate mutase
FR729_RS01025	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FR729_RS01030	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
FR729_RS01035	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FR729_RS01040	COG0564	pseudouridine synthase activity
FR729_RS01050	COG0542	response to heat
FR729_RS01105	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FR729_RS01115	COG2974	May be involved in recombination
FR729_RS01120	COG0745	RESPONSE REGULATOR receiver
FR729_RS01125	COG5002	protein histidine kinase activity
FR729_RS01135	COG0248	Ppx GppA phosphatase
FR729_RS01140	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FR729_RS01145	COG0573	inorganic phosphate transmembrane transporter activity
FR729_RS01150	COG0581	inorganic phosphate transmembrane transporter activity
FR729_RS01155	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FR729_RS01160	COG0704	Plays a role in the regulation of phosphate uptake
FR729_RS01170	COG3142	Participates in the control of copper homeostasis
FR729_RS01175	COG0450	alkyl hydroperoxide reductase
FR729_RS01180	COG0583	DNA-binding transcription factor activity
FR729_RS01185	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
FR729_RS01195	COG0517	IMP dehydrogenase activity
FR729_RS01205	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FR729_RS01215	COG1862	Preprotein translocase
FR729_RS01220	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FR729_RS01225	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FR729_RS01230	COG0483	inositol monophosphate 1-phosphatase activity
FR729_RS01235	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
FR729_RS01245	COG1104	cysteine desulfurase activity
FR729_RS01250	COG0822	iron-sulfur transferase activity
FR729_RS01265	COG0443	Heat shock 70 kDa protein
FR729_RS01270	COG0633	Ferredoxin
FR729_RS01275	COG2975	iron-sulfur cluster assembly
FR729_RS01285	COG0105	UTP biosynthetic process
FR729_RS01300	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FR729_RS01305	COG0124	histidyl-tRNA synthetase
FR729_RS01310	COG2976	Protein conserved in bacteria
FR729_RS01315	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FR729_RS01320	COG1160	GTP binding
FR729_RS01340	COG0516	GMP reductase activity
FR729_RS01340	COG0517	IMP dehydrogenase activity
FR729_RS01345	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FR729_RS01345	COG0519	Catalyzes the synthesis of GMP from XMP
FR729_RS01350	COG1757	Na H antiporter
FR729_RS01360	COG1584	GPR1 FUN34 yaaH family protein
FR729_RS01365	COG1115	amino acid carrier protein
FR729_RS01380	COG2873	o-acetylhomoserine
FR729_RS01385	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FR729_RS01405	COG3153	acetyltransferase
FR729_RS01405	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FR729_RS01410	COG0583	DNA-binding transcription factor activity
FR729_RS01430	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FR729_RS01435	COG2867	negative regulation of translational initiation
FR729_RS01440	COG2914	Belongs to the UPF0125 (RnfH) family
FR729_RS01445	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FR729_RS01455	COG0497	DNA recombination
FR729_RS01465	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FR729_RS01470	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FR729_RS01475	COG1301	dicarboxylic acid transport
FR729_RS01485	COG0484	heat shock protein binding
FR729_RS01515	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
FR729_RS01525	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
FR729_RS01530	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FR729_RS01530	COG0047	phosphoribosylformylglycinamidine synthase activity
FR729_RS01560	COG2195	Cleaves the N-terminal amino acid of tripeptides
FR729_RS01565	COG2252	PERMEase
FR729_RS01570	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
FR729_RS01585	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FR729_RS01590	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FR729_RS01595	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FR729_RS01600	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FR729_RS01600	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FR729_RS01615	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FR729_RS01625	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
FR729_RS01630	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
FR729_RS01640	COG0142	geranyltranstransferase activity
FR729_RS01645	COG1722	exodeoxyribonuclease VII activity
FR729_RS01650	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
FR729_RS01660	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FR729_RS01660	COG0301	tRNA thio-modification
FR729_RS01665	COG0583	DNA-binding transcription factor activity
FR729_RS01675	COG2363	Small membrane protein
FR729_RS01685	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FR729_RS01690	COG1611	Belongs to the LOG family
FR729_RS01705	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FR729_RS01705	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FR729_RS01715	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
FR729_RS01720	COG1464	Belongs to the NlpA lipoprotein family
FR729_RS01725	COG2011	ABC-type metal ion transport system permease component
FR729_RS01730	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FR729_RS01735	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FR729_RS01745	COG1263	PTS System
FR729_RS01745	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FR729_RS01750	COG0366	Alpha amylase catalytic
FR729_RS01765	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FR729_RS01770	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FR729_RS01775	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FR729_RS01780	COG0321	lipoyl(octanoyl) transferase activity
FR729_RS01790	COG1686	Belongs to the peptidase S11 family
FR729_RS01795	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FR729_RS01800	COG0772	Belongs to the SEDS family
FR729_RS01805	COG0768	penicillin binding
FR729_RS01810	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
FR729_RS01815	COG0799	negative regulation of ribosome biogenesis
FR729_RS01820	COG1466	dna polymerase III delta subunit
FR729_RS01825	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
FR729_RS01830	COG0495	leucyl-tRNA aminoacylation
FR729_RS01835	COG2888	peptidyl-tyrosine sulfation
FR729_RS01840	COG0815	Transfers the fatty acyl group on membrane lipoproteins
FR729_RS01845	COG4535	Mg2 and Co2 transporter CorC
FR729_RS01850	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FR729_RS01855	COG1702	phosphate starvation-inducible protein PhoH
FR729_RS01860	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FR729_RS01865	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FR729_RS01970	COG0012	GTP binding
FR729_RS01975	COG0193	aminoacyl-tRNA hydrolase activity
FR729_RS01980	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FR729_RS01985	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FR729_RS01990	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
FR729_RS01995	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FR729_RS02005	COG2890	protein-(glutamine-N5) methyltransferase activity
FR729_RS02010	COG3094	Invasion gene expression up-regulator, SirB
FR729_RS02015	COG2912	Transglutaminase-like superfamily
FR729_RS02020	COG2877	3-deoxy-8-phosphooctulonate synthase activity
FR729_RS02025	COG0737	Belongs to the 5'-nucleotidase family
FR729_RS02030	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FR729_RS02035	COG1187	pseudouridine synthase activity
FR729_RS02040	COG2840	Smr protein MutS2
FR729_RS02080	COG2608	mercury ion transmembrane transporter activity
FR729_RS02080	COG2217	Heavy metal translocating P-type atpase
FR729_RS02090	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
FR729_RS02145	COG0784	Response regulator, receiver
FR729_RS02145	COG0835	chemotaxis
FR729_RS02150	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
FR729_RS02155	COG1815	bacterial-type flagellum-dependent cell motility
FR729_RS02160	COG1558	bacterial-type flagellum-dependent cell motility
FR729_RS02170	COG1749	Flagellar hook protein flgE
FR729_RS02175	COG4787	bacterial-type flagellum-dependent cell motility
FR729_RS02185	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
FR729_RS02190	COG1706	bacterial-type flagellum-dependent cell motility
FR729_RS02195	COG1705	Flagellar rod assembly protein muramidase FlgJ
FR729_RS02195	COG3951	Flagellar rod assembly protein muramidase FlgJ
FR729_RS02205	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FR729_RS02210	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FR729_RS02215	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FR729_RS02220	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FR729_RS02225	COG2190	(PTS) system
FR729_RS02230	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FR729_RS02235	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FR729_RS02240	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FR729_RS02245	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
FR729_RS02250	COG3115	cell septum assembly
FR729_RS02255	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FR729_RS02275	COG0330	HflC and HflK could
FR729_RS02280	COG3118	belongs to the thioredoxin family
FR729_RS02285	COG0300	oxidoreductase activity
FR729_RS02290	COG1090	epimerase
FR729_RS02320	COG0622	Phosphoesterase
FR729_RS02340	COG3710	Transcriptional regulator
FR729_RS02345	COG0326	Molecular chaperone. Has ATPase activity
FR729_RS02355	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FR729_RS02360	COG3104	oligopeptide transport
FR729_RS02365	COG0250	Participates in transcription elongation, termination and antitermination
FR729_RS02370	COG0367	asparagine synthase
FR729_RS02375	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FR729_RS02375	COG4651	solute:proton antiporter activity
FR729_RS02380	COG1846	Transcriptional regulator
FR729_RS02380	COG1940	carbohydrate kinase activity
FR729_RS02385	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FR729_RS02390	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FR729_RS02390	COG1263	PTS System
FR729_RS02390	COG2190	(PTS) system
FR729_RS02395	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FR729_RS02400	COG0735	belongs to the Fur family
FR729_RS02410	COG0716	FMN binding
FR729_RS02420	COG0596	Alpha beta hydrolase
FR729_RS02425	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
FR729_RS02430	COG0033	Phosphoglucomutase
FR729_RS02440	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FR729_RS02455	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
FR729_RS02460	COG1053	succinate dehydrogenase
FR729_RS02465	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FR729_RS02470	COG0567	Dehydrogenase, E1 component
FR729_RS02475	COG0508	dehydrogenase complex catalyzes the overall conversion of
FR729_RS02480	COG0045	succinate-CoA ligase (ADP-forming) activity
FR729_RS02490	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FR729_RS02495	COG1121	(ABC) transporter
FR729_RS02500	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
FR729_RS02505	COG4977	sequence-specific DNA binding
FR729_RS02510	COG1918	ferrous iron import across plasma membrane
FR729_RS02530	COG0018	arginyl-trna synthetase
FR729_RS02535	COG3102	Protein conserved in bacteria
FR729_RS02550	COG0788	formyltetrahydrofolate deformylase activity
FR729_RS02555	COG1199	ATP-dependent helicase activity
FR729_RS02560	COG1214	PFAM Peptidase M22, glycoprotease
FR729_RS02570	COG3065	identical protein binding
FR729_RS02575	COG2267	carboxylic ester hydrolase activity
FR729_RS02580	COG0318	PFAM AMP-dependent synthetase and ligase
FR729_RS02585	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
FR729_RS02590	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
FR729_RS02595	COG2894	cell division
FR729_RS02600	COG0850	regulation of cytokinetic process
FR729_RS02605	COG3100	YcgL domain-containing protein
FR729_RS02610	COG2951	lytic endotransglycosylase activity
FR729_RS02620	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FR729_RS02625	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FR729_RS02635	COG2226	methyltransferase
FR729_RS02645	COG1028	Short-chain dehydrogenase reductase Sdr
FR729_RS02655	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FR729_RS02680	COG2986	histidine ammonia-lyase
FR729_RS02685	COG1216	Glycosyl transferase, family 2
FR729_RS02690	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FR729_RS02705	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FR729_RS02710	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FR729_RS02745	COG0513	Belongs to the DEAD box helicase family
FR729_RS02750	COG0569	domain protein
FR729_RS02755	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FR729_RS02770	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
FR729_RS02775	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FR729_RS02780	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FR729_RS02785	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FR729_RS02810	COG0544	peptidyl-prolyl cis-trans isomerase activity
FR729_RS02820	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FR729_RS02825	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FR729_RS02830	COG0776	regulation of translation
FR729_RS02835	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FR729_RS02840	COG1555	photosystem II stabilization
FR729_RS02855	COG0232	Belongs to the dGTPase family. Type 2 subfamily
FR729_RS02860	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
FR729_RS02865	COG0436	Aminotransferase
FR729_RS02870	COG1169	isochorismate synthase
FR729_RS02875	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
FR729_RS02885	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
FR729_RS02905	COG2855	membrane
FR729_RS02910	COG0477	Major facilitator Superfamily
FR729_RS02955	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FR729_RS02960	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FR729_RS02980	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FR729_RS02985	COG1522	sequence-specific DNA binding
FR729_RS02995	COG1946	Acyl-CoA thioesterase
FR729_RS03000	COG3126	Type III secretion system lipoprotein chaperone (YscW)
FR729_RS03015	COG3706	GGDEF domain
FR729_RS03025	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FR729_RS03030	COG0517	IMP dehydrogenase activity
FR729_RS03030	COG0516	GMP reductase activity
FR729_RS03055	COG0537	adenosine 5'-monophosphoramidase activity
FR729_RS03080	COG3150	esterase
FR729_RS03085	COG1252	NADH dehydrogenase
FR729_RS03100	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FR729_RS03110	COG4591	ABC-type transport system involved in lipoprotein release permease component
FR729_RS03115	COG1136	(ABC) transporter
FR729_RS03120	COG4591	ABC-type transport system involved in lipoprotein release permease component
FR729_RS03130	COG0658	competence protein
FR729_RS03130	COG2333	competence protein COMEC
FR729_RS03135	COG1132	(ABC) transporter
FR729_RS03155	COG2719	SpoVR family
FR729_RS03160	COG2718	Belongs to the UPF0229 family
FR729_RS03165	COG2766	serine protein kinase
FR729_RS03170	COG3013	Belongs to the UPF0304 family
FR729_RS03180	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FR729_RS03190	COG1882	Formate acetyltransferase
FR729_RS03230	COG0708	Exodeoxyribonuclease III
FR729_RS03240	COG3923	Primosomal replication protein n
FR729_RS03245	COG0730	response to heat
FR729_RS03250	COG1199	ATP-dependent helicase activity
FR729_RS03255	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
FR729_RS03260	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
FR729_RS03265	COG1187	pseudouridine synthase activity
FR729_RS03275	COG1278	Cold shock
FR729_RS03280	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FR729_RS03285	COG0542	response to heat
FR729_RS03290	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FR729_RS03295	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
FR729_RS03300	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
FR729_RS03320	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FR729_RS03325	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FR729_RS03330	COG0297	glycogen (starch) synthase activity
FR729_RS03350	COG3070	regulator of competence-specific genes
FR729_RS03355	COG1609	Transcriptional regulator
FR729_RS03360	COG3381	protein complex oligomerization
FR729_RS03365	COG0745	RESPONSE REGULATOR receiver
FR729_RS03370	COG1434	Gram-negative-bacterium-type cell wall biogenesis
FR729_RS03375	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FR729_RS03380	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
FR729_RS03385	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
FR729_RS03390	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
FR729_RS03410	COG4067	protein conserved in archaea
FR729_RS03410	COG0189	ligase activity
FR729_RS03415	COG0500	methyltransferase
FR729_RS03425	COG1801	Protein of unknown function DUF72
FR729_RS03435	COG0217	transcriptional regulatory protein
FR729_RS03440	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FR729_RS03445	COG0632	four-way junction helicase activity
FR729_RS03450	COG2255	four-way junction helicase activity
FR729_RS03455	COG1271	oxidase subunit
FR729_RS03460	COG1294	oxidase, subunit
FR729_RS03465	COG4890	Cyd operon protein YbgT
FR729_RS03475	COG0824	Thioesterase
FR729_RS03480	COG0811	peptide transport
FR729_RS03495	COG0823	Involved in the tonB-independent uptake of proteins
FR729_RS03500	COG2885	chlorophyll binding
FR729_RS03505	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
FR729_RS03510	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FR729_RS03520	COG3766	membrane
FR729_RS03530	COG0754	glutathionylspermidine amidase activity
FR729_RS03540	COG0784	Response regulator, receiver
FR729_RS03540	COG5002	protein histidine kinase activity
FR729_RS03555	COG1294	oxidase, subunit
FR729_RS03560	COG1271	oxidase subunit
FR729_RS03580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FR729_RS03585	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FR729_RS03610	COG3568	Endonuclease Exonuclease Phosphatase
FR729_RS03635	COG0583	DNA-binding transcription factor activity
FR729_RS03645	COG0686	Belongs to the AlaDH PNT family
FR729_RS03655	COG1674	ftsk spoiiie
FR729_RS03665	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FR729_RS03675	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FR729_RS03700	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
FR729_RS03720	COG0300	oxidoreductase activity
FR729_RS03735	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FR729_RS03745	COG2268	Band 7 protein
FR729_RS03755	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FR729_RS03760	COG2915	High frequency lysogenization protein hflD homolog
FR729_RS03775	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FR729_RS03785	COG1757	Na H antiporter
FR729_RS03800	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FR729_RS03810	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FR729_RS03810	COG0131	Imidazoleglycerol-phosphate dehydratase
FR729_RS03815	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FR729_RS03820	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FR729_RS03830	COG0140	phosphoribosyl-ATP diphosphatase activity
FR729_RS03830	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FR729_RS03835	COG3012	SEC-C Motif Domain Protein
FR729_RS03840	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
FR729_RS03845	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FR729_RS03850	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FR729_RS03855	COG0215	cysteine-tRNA ligase activity
FR729_RS03860	COG1435	thymidine kinase activity
FR729_RS03890	COG2116	formate transmembrane transporter activity
FR729_RS03895	COG0390	transport system, permease component
FR729_RS03900	COG4459	periplasmic nitrate reductase
FR729_RS03905	COG3005	denitrification pathway
FR729_RS03910	COG0243	molybdopterin cofactor binding
FR729_RS03925	COG1227	inorganic diphosphatase activity
FR729_RS03935	COG4172	Belongs to the ABC transporter superfamily
FR729_RS03945	COG4171	peptide transport system, permease
FR729_RS03960	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
FR729_RS03965	COG1842	Phage shock protein A
FR729_RS03975	COG1983	PspC domain protein
FR729_RS03995	COG2818	Glycosylase
FR729_RS04000	COG5380	lipid catabolic process
FR729_RS04005	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
FR729_RS04010	COG0626	cystathionine gamma-synthase activity
FR729_RS04020	COG0733	neurotransmitter:sodium symporter activity
FR729_RS04025	COG0564	pseudouridine synthase activity
FR729_RS04035	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FR729_RS04040	COG1151	hydroxylamine reductase activity
FR729_RS04045	COG3604	Transcriptional regulator
FR729_RS04055	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FR729_RS04060	COG4136	ATPase activity
FR729_RS04065	COG4135	transport system, permease component
FR729_RS04070	COG4134	Bacterial extracellular solute-binding protein
FR729_RS04080	COG3313	Fe-S protein
FR729_RS04100	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FR729_RS04105	COG2205	protein histidine kinase activity
FR729_RS04110	COG0745	RESPONSE REGULATOR receiver
FR729_RS04120	COG1061	Type III restriction enzyme res subunit
FR729_RS04125	COG1187	pseudouridine synthase activity
FR729_RS04130	COG2814	Major facilitator Superfamily
FR729_RS04140	COG0702	epimerase
FR729_RS04145	COG0534	Mate efflux family protein
FR729_RS04165	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FR729_RS04175	COG1960	acyl-CoA dehydrogenase activity
FR729_RS04180	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FR729_RS04185	COG2985	domain, Protein
FR729_RS04185	COG3273	potassium ion transport
FR729_RS04190	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FR729_RS04200	COG1737	Transcriptional regulator
FR729_RS04205	COG0076	glutamate decarboxylase activity
FR729_RS04215	COG2431	L-lysine efflux transmembrane transporter activity
FR729_RS04225	COG3070	regulator of competence-specific genes
FR729_RS04240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FR729_RS04240	COG4191	Histidine kinase
FR729_RS04250	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
FR729_RS04260	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
FR729_RS04265	COG4988	ABC transporter
FR729_RS04270	COG0492	ferredoxin-NADP+ reductase activity
FR729_RS04295	COG0471	metal ion transport
FR729_RS04300	COG2949	membrane
FR729_RS04305	COG0281	malic enzyme
FR729_RS04310	COG1643	Atp-dependent helicase
FR729_RS04325	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FR729_RS04360	COG0247	lactate metabolic process
FR729_RS04360	COG0277	FAD linked oxidase domain protein
FR729_RS04375	COG2986	histidine ammonia-lyase
FR729_RS04380	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
FR729_RS04385	COG0010	Belongs to the arginase family
FR729_RS04390	COG1228	amidohydrolase
FR729_RS04395	COG2188	Transcriptional regulator
FR729_RS04410	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FR729_RS04420	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FR729_RS04430	COG0393	Putative heavy-metal-binding
FR729_RS04465	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FR729_RS04470	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FR729_RS04470	COG0072	phenylalanine-tRNA ligase activity
FR729_RS04480	COG0776	regulation of translation
FR729_RS04490	COG0500	methyltransferase
FR729_RS04495	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
FR729_RS04500	COG0295	cytidine deaminase activity
FR729_RS04505	COG1346	cytolysis
FR729_RS04510	COG1380	Effector of murein hydrolase LrgA
FR729_RS04515	COG2925	Exonuclease
FR729_RS04525	COG0702	epimerase
FR729_RS04530	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
FR729_RS04535	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
FR729_RS04555	COG2988	succinylglutamate desuccinylase activity
FR729_RS04560	COG4139	cobalamin transport
FR729_RS04565	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
FR729_RS04585	COG0583	DNA-binding transcription factor activity
FR729_RS04595	COG1451	nucleotide metabolic process
FR729_RS04600	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
FR729_RS04630	COG3938	Belongs to the proline racemase family
FR729_RS04645	COG2423	ornithine cyclodeaminase activity
FR729_RS04650	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FR729_RS04655	COG3842	ATPase activity
FR729_RS04665	COG1177	transmembrane transport
FR729_RS04675	COG3291	Pkd domain containing protein
FR729_RS04695	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FR729_RS04700	COG0601	transmembrane transport
FR729_RS04710	COG2195	Cleaves the N-terminal amino acid of tripeptides
FR729_RS04720	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
FR729_RS04730	COG0625	glutathione transferase activity
FR729_RS04780	COG3755	Protein conserved in bacteria
FR729_RS04805	COG1742	UPF0060 membrane protein
FR729_RS04820	COG1757	Na H antiporter
FR729_RS04825	COG0174	glutamine synthetase
FR729_RS04830	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
FR729_RS04835	COG1917	Cupin 2, conserved barrel domain protein
FR729_RS04835	COG1396	sequence-specific DNA binding
FR729_RS04840	COG1012	belongs to the aldehyde dehydrogenase family
FR729_RS04845	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FR729_RS04855	COG2957	Belongs to the agmatine deiminase family
FR729_RS04860	COG1012	belongs to the aldehyde dehydrogenase family
FR729_RS04865	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FR729_RS04870	COG2200	EAL domain
FR729_RS04880	COG1846	Transcriptional regulator
FR729_RS04885	COG2315	Protein conserved in bacteria
FR729_RS04925	COG3063	Type IV pilus biogenesis stability protein PilW
FR729_RS04930	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
FR729_RS04945	COG1560	Kdo2-lipid A biosynthetic process
FR729_RS04950	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
FR729_RS04955	COG1280	lysine exporter protein (LysE YggA)
FR729_RS04965	COG1115	amino acid carrier protein
FR729_RS04990	COG1368	sulfuric ester hydrolase activity
FR729_RS04995	COG2113	Glycine betaine
FR729_RS05000	COG4176	ABC-type proline glycine betaine transport system permease component
FR729_RS05005	COG4175	Glycine betaine
FR729_RS05020	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FR729_RS05025	COG0456	acetyltransferase
FR729_RS05030	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
FR729_RS05035	COG0662	Cupin 2, conserved barrel domain protein
FR729_RS05040	COG0527	aspartate kinase activity
FR729_RS05050	COG3119	arylsulfatase activity
FR729_RS05065	COG0641	radical SAM
FR729_RS05080	COG3119	arylsulfatase activity
FR729_RS05105	COG1538	Outer membrane efflux protein
FR729_RS05120	COG1349	DNA-binding transcription factor activity
FR729_RS05125	COG0673	inositol 2-dehydrogenase activity
FR729_RS05130	COG4702	Belongs to the UPF0303 family
FR729_RS05155	COG0471	metal ion transport
FR729_RS05170	COG5001	Diguanylate cyclase
FR729_RS05170	COG3300	MHYT domain
FR729_RS05185	COG1328	CTP reductase activity
FR729_RS05190	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FR729_RS05200	COG0861	Integral membrane protein TerC family
FR729_RS05210	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
FR729_RS05220	COG0814	amino acid
FR729_RS05235	COG1120	ATPase activity
FR729_RS05240	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FR729_RS05250	COG4774	siderophore transport
FR729_RS05260	COG1132	(ABC) transporter
FR729_RS05265	COG1132	(ABC) transporter
FR729_RS05280	COG0583	DNA-binding transcription factor activity
FR729_RS05305	COG0443	Heat shock 70 kDa protein
FR729_RS05310	COG0443	Heat shock 70 kDa protein
FR729_RS05355	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FR729_RS05360	COG1643	Atp-dependent helicase
FR729_RS05375	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FR729_RS05385	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FR729_RS05390	COG1215	transferase activity, transferring glycosyl groups
FR729_RS05395	COG0438	transferase activity, transferring glycosyl groups
FR729_RS05425	COG0438	transferase activity, transferring glycosyl groups
FR729_RS05430	COG0297	glycogen (starch) synthase activity
FR729_RS05435	COG2204	response regulator
FR729_RS05465	COG1793	dna ligase
FR729_RS05475	COG0534	Mate efflux family protein
FR729_RS05480	COG0307	riboflavin synthase, alpha
FR729_RS05490	COG3001	Fructosamine kinase
FR729_RS05500	COG3706	GGDEF domain
FR729_RS05510	COG0791	NLP P60 protein
FR729_RS05550	COG1940	carbohydrate kinase activity
FR729_RS05560	COG0303	'Molybdopterin
FR729_RS05565	COG0746	molybdenum cofactor guanylyltransferase activity
FR729_RS05570	COG3842	ATPase activity
FR729_RS05585	COG2204	response regulator
FR729_RS05590	COG4191	Histidine kinase
FR729_RS05595	COG0488	(ABC) transporter
FR729_RS05600	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FR729_RS05620	COG3381	protein complex oligomerization
FR729_RS05630	COG3383	formate dehydrogenase (NAD+) activity
FR729_RS05630	COG0243	molybdopterin cofactor binding
FR729_RS05635	COG0437	4 iron, 4 sulfur cluster binding
FR729_RS05660	COG0004	ammonium transporteR
FR729_RS05670	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FR729_RS05680	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FR729_RS05690	COG1177	transmembrane transport
FR729_RS05700	COG3842	ATPase activity
FR729_RS05725	COG0589	response to stress
FR729_RS05730	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FR729_RS05745	COG2217	Heavy metal translocating P-type atpase
FR729_RS05755	COG2010	Cytochrome c
FR729_RS05770	COG3278	Belongs to the heme-copper respiratory oxidase family
FR729_RS05785	COG0784	Response regulator, receiver
FR729_RS05785	COG2205	protein histidine kinase activity
FR729_RS05800	COG3120	sequence-specific DNA binding
FR729_RS05805	COG1067	ATP-dependent peptidase activity
FR729_RS05810	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FR729_RS05835	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FR729_RS05835	COG0116	Belongs to the methyltransferase superfamily
FR729_RS05845	COG0167	dihydroorotate dehydrogenase activity
FR729_RS05850	COG2902	Dehydrogenase
FR729_RS05860	COG0308	aminopeptidase N
FR729_RS05875	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
FR729_RS05880	COG1956	GAF domain-containing protein
FR729_RS05885	COG1132	(ABC) transporter
FR729_RS05890	COG2995	paraquat-inducible protein a
FR729_RS05895	COG3008	intermembrane lipid transfer
FR729_RS05920	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FR729_RS05925	COG1666	GTP binding
FR729_RS05935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FR729_RS05940	COG4597	amino acid ABC transporter
FR729_RS05945	COG0765	amino acid transport
FR729_RS05950	COG1126	abc transporter atp-binding protein
FR729_RS05955	COG0670	Belongs to the BI1 family
FR729_RS05965	COG2920	part of a sulfur-relay system
FR729_RS05970	COG1254	Belongs to the acylphosphatase family
FR729_RS06025	COG2203	Gaf domain
FR729_RS06025	COG2199	diguanylate cyclase activity
FR729_RS06030	COG1414	Transcriptional regulator
FR729_RS06040	COG0656	L-ascorbic acid biosynthetic process
FR729_RS06045	COG0583	DNA-binding transcription factor activity
FR729_RS06055	COG0583	DNA-binding transcription factor activity
FR729_RS06060	COG2814	Major facilitator Superfamily
FR729_RS06080	COG1335	isochorismatase
FR729_RS06085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FR729_RS06100	COG1410	methionine synthase
FR729_RS06100	COG0646	methionine synthase
FR729_RS06105	COG1126	abc transporter atp-binding protein
FR729_RS06110	COG0765	amino acid transport
FR729_RS06115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FR729_RS06130	COG0583	DNA-binding transcription factor activity
FR729_RS06145	COG0583	DNA-binding transcription factor activity
FR729_RS06150	COG0583	DNA-binding transcription factor activity
FR729_RS06165	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FR729_RS06170	COG0602	queuosine metabolic process
FR729_RS06175	COG0561	phosphatase activity
FR729_RS06200	COG2828	Protein conserved in bacteria
FR729_RS06210	COG0372	Belongs to the citrate synthase family
FR729_RS06215	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
FR729_RS06250	COG0730	response to heat
FR729_RS06255	COG2358	TRAP transporter, solute receptor (TAXI family
FR729_RS06275	COG0457	Tetratricopeptide repeat
FR729_RS06345	COG4790	Type iii secretion
FR729_RS06350	COG4794	Type iii secretion
FR729_RS06355	COG4791	protein targeting
FR729_RS06360	COG4792	protein secretion
FR729_RS06365	COG2207	Transcriptional regulator
FR729_RS06395	COG3177	Filamentation induced by cAMP protein fic
FR729_RS06415	COG4669	(LipO)protein
FR729_RS06485	COG1012	belongs to the aldehyde dehydrogenase family
FR729_RS06490	COG3284	Transcriptional regulator
FR729_RS06505	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
FR729_RS06510	COG0363	glucosamine-6-phosphate deaminase activity
FR729_RS06515	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FR729_RS06520	COG2207	Transcriptional regulator
FR729_RS06530	COG4565	transcriptional regulatory protein
FR729_RS06535	COG3290	protein histidine kinase activity
FR729_RS06550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FR729_RS06565	COG0583	DNA-binding transcription factor activity
FR729_RS06580	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
FR729_RS06590	COG2985	domain, Protein
FR729_RS06615	COG2272	Belongs to the type-B carboxylesterase lipase family
FR729_RS06620	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FR729_RS06625	COG0729	surface antigen
FR729_RS06635	COG1280	lysine exporter protein (LysE YggA)
FR729_RS06640	COG1280	lysine exporter protein (LysE YggA)
FR729_RS06645	COG5507	3-demethylubiquinone-9 3-methyltransferase
FR729_RS06665	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FR729_RS06670	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FR729_RS06675	COG0110	maltose O-acetyltransferase activity
FR729_RS06840	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
FR729_RS06850	COG2801	Transposase and inactivated derivatives
FR729_RS06895	COG2226	methyltransferase
FR729_RS07120	COG2026	Addiction module toxin, RelE StbE family
FR729_RS07155	COG2801	Transposase and inactivated derivatives
FR729_RS07375	COG2801	Transposase and inactivated derivatives
FR729_RS07595	COG0625	glutathione transferase activity
FR729_RS07640	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FR729_RS07650	COG3768	UPF0283 membrane protein
FR729_RS07655	COG3106	COG3106 Predicted ATPase
FR729_RS07670	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FR729_RS07675	COG0784	Response regulator, receiver
FR729_RS07675	COG2205	protein histidine kinase activity
FR729_RS07685	COG0494	nUDIX hydrolase
FR729_RS07690	COG0814	amino acid
FR729_RS07695	COG1760	l-serine dehydratase
FR729_RS07700	COG2200	EAL domain
FR729_RS07710	COG0720	synthase
FR729_RS07715	COG0840	transmembrane signaling receptor activity
FR729_RS07720	COG0017	Asparaginyl-tRNA synthetase
FR729_RS07730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FR729_RS07745	COG1448	Aminotransferase
FR729_RS07765	COG0840	transmembrane signaling receptor activity
FR729_RS07770	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FR729_RS07800	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
FR729_RS07815	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FR729_RS07820	COG3108	Peptidase M15
FR729_RS07825	COG2989	Protein conserved in bacteria
FR729_RS07850	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FR729_RS07860	COG4235	cytochrome complex assembly
FR729_RS07860	COG3088	subunit of a heme lyase
FR729_RS07870	COG1138	Cytochrome C-type biogenesis protein
FR729_RS07875	COG3301	Polysulphide reductase, NrfD
FR729_RS07880	COG0437	4 iron, 4 sulfur cluster binding
FR729_RS07890	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
FR729_RS07910	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FR729_RS07915	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FR729_RS07945	COG0019	diaminopimelate decarboxylase activity
FR729_RS07985	COG0322	excinuclease ABC activity
FR729_RS07990	COG2197	response regulator
FR729_RS07995	COG0417	DNA replication proofreading
FR729_RS08015	COG1187	pseudouridine synthase activity
FR729_RS08025	COG0009	L-threonylcarbamoyladenylate synthase
FR729_RS08030	COG0613	PHP domain protein
FR729_RS08040	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FR729_RS08045	COG0512	Glutamine amidotransferase of anthranilate synthase
FR729_RS08055	COG0134	indole-3-glycerol-phosphate synthase activity
FR729_RS08055	COG0135	phosphoribosylanthranilate isomerase activity
FR729_RS08065	COG0159	tryptophan synthase activity
FR729_RS08070	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FR729_RS08075	COG0318	PFAM AMP-dependent synthetase and ligase
FR729_RS08080	COG1301	dicarboxylic acid transport
FR729_RS08100	COG2917	probably involved in intracellular septation
FR729_RS08110	COG2350	Protein conserved in bacteria
FR729_RS08120	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FR729_RS08125	COG0583	DNA-binding transcription factor activity
FR729_RS08140	COG5001	Diguanylate cyclase
FR729_RS08145	COG1032	radical SAM domain protein
FR729_RS08165	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
FR729_RS08170	COG0463	Glycosyl transferase, family 2
FR729_RS08175	COG0745	RESPONSE REGULATOR receiver
FR729_RS08180	COG3850	Histidine kinase
FR729_RS08180	COG5002	protein histidine kinase activity
FR729_RS08230	COG1335	isochorismatase
FR729_RS08235	COG1136	(ABC) transporter
FR729_RS08235	COG0577	efflux transmembrane transporter activity
FR729_RS08240	COG1136	(ABC) transporter
FR729_RS08240	COG0577	efflux transmembrane transporter activity
FR729_RS08245	COG0577	efflux transmembrane transporter activity
FR729_RS08245	COG1136	(ABC) transporter
FR729_RS08255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FR729_RS08280	COG3118	belongs to the thioredoxin family
FR729_RS08285	COG4232	protein-disulfide reductase activity
FR729_RS08320	COG2863	cytochrome
FR729_RS08325	COG3258	Cytochrome c
FR729_RS08330	COG2995	paraquat-inducible protein a
FR729_RS08335	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FR729_RS08335	COG3008	intermembrane lipid transfer
FR729_RS08355	COG4166	transmembrane transport
FR729_RS08365	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
FR729_RS08370	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
FR729_RS08380	COG0539	negative regulation of cytoplasmic translation
FR729_RS08385	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FR729_RS08390	COG0616	signal peptide processing
FR729_RS08395	COG1028	Short-chain dehydrogenase reductase Sdr
FR729_RS08410	COG0587	DNA-directed DNA polymerase activity
FR729_RS08415	COG0835	chemotaxis
FR729_RS08415	COG0784	Response regulator, receiver
FR729_RS08420	COG1940	carbohydrate kinase activity
FR729_RS08425	COG0469	pyruvate kinase activity
FR729_RS08430	COG4667	esterase of the alpha-beta hydrolase superfamily
FR729_RS08445	COG0733	neurotransmitter:sodium symporter activity
FR729_RS08460	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FR729_RS08460	COG1263	PTS System
FR729_RS08465	COG0084	hydrolase, TatD family'
FR729_RS08470	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FR729_RS08475	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FR729_RS08480	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FR729_RS08510	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FR729_RS08515	COG0416	fatty acid biosynthetic process
FR729_RS08525	COG1399	metal-binding, possibly nucleic acid-binding protein
FR729_RS08530	COG0424	maF-like protein
FR729_RS08535	COG0564	pseudouridine synthase activity
FR729_RS08540	COG1530	ribonuclease E activity
FR729_RS08545	COG0659	secondary active sulfate transmembrane transporter activity
FR729_RS08550	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FR729_RS08555	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
FR729_RS08565	COG0572	uridine kinase
FR729_RS08575	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FR729_RS08575	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FR729_RS08585	COG2186	Transcriptional regulator
FR729_RS08590	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FR729_RS08595	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
FR729_RS08600	COG3318	Belongs to the UPF0149 family
FR729_RS08600	COG3012	SEC-C Motif Domain Protein
FR729_RS08605	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FR729_RS08610	COG3706	GGDEF domain
FR729_RS08615	COG0366	Alpha amylase catalytic
FR729_RS08620	COG1122	ATPase activity
FR729_RS08625	COG4120	Belongs to the binding-protein-dependent transport system permease family
FR729_RS08635	COG3092	negative regulation of chromosome organization
FR729_RS08640	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FR729_RS08645	COG0280	phosphate acetyltransferase
FR729_RS08645	COG0857	belongs to the CobB CobQ family
FR729_RS08655	COG0435	Glutathione S-transferase
FR729_RS08665	COG0444	Belongs to the ABC transporter superfamily
FR729_RS08670	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FR729_RS08675	COG0601	transmembrane transport
FR729_RS08685	COG0314	molybdopterin synthase activity
FR729_RS08690	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
FR729_RS08695	COG0315	cyclic pyranopterin monophosphate synthase activity
FR729_RS08700	COG0521	Mo-molybdopterin cofactor biosynthetic process
FR729_RS08705	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FR729_RS08710	COG0391	Required for morphogenesis under gluconeogenic growth conditions
FR729_RS08715	COG2198	Histidine kinase
FR729_RS08720	COG2204	response regulator
FR729_RS08725	COG0556	nucleotide-excision repair
FR729_RS08735	COG1882	Formate acetyltransferase
FR729_RS08740	COG4657	Part of a membrane complex involved in electron transport
FR729_RS08745	COG2878	Part of a membrane complex involved in electron transport
FR729_RS08750	COG4656	Part of a membrane complex involved in electron transport
FR729_RS08755	COG4658	electron transport chain
FR729_RS08760	COG4659	FMN binding
FR729_RS08765	COG4660	Part of a membrane complex involved in electron transport
FR729_RS08770	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FR729_RS08775	COG0346	lactoylglutathione lyase activity
FR729_RS08785	COG2885	chlorophyll binding
FR729_RS08790	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FR729_RS08795	COG2056	Na+-H+ antiporter family
FR729_RS08805	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FR729_RS08825	COG1012	belongs to the aldehyde dehydrogenase family
FR729_RS08825	COG1454	alcohol dehydrogenase
FR729_RS08830	COG2095	MarC family integral membrane protein
FR729_RS08835	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FR729_RS08840	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FR729_RS08845	COG1757	Na H antiporter
FR729_RS08860	COG3081	Nucleoid-associated protein
FR729_RS08865	COG3082	Protein of unknown function (DUF1414)
FR729_RS08880	COG0123	including yeast histone deacetylase and acetoin utilization protein
FR729_RS08895	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FR729_RS08900	COG0778	Nitroreductase
FR729_RS08910	COG1902	pentaerythritol trinitrate reductase activity
FR729_RS08910	COG0446	pyridine nucleotide-disulphide oxidoreductase
FR729_RS08915	COG0616	signal peptide processing
FR729_RS08920	COG0252	asparaginase activity
FR729_RS08925	COG3139	Protein of unknown function (DUF1315)
FR729_RS08935	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FR729_RS08940	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FR729_RS08955	COG2226	methyltransferase
FR729_RS08970	COG1785	Belongs to the alkaline phosphatase family
FR729_RS08980	COG0346	lactoylglutathione lyase activity
FR729_RS08985	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
FR729_RS08990	COG0668	transmembrane transport
FR729_RS08995	COG2983	Belongs to the UPF0260 family
FR729_RS09000	COG2261	transglycosylase associated protein
FR729_RS09010	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FR729_RS09015	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FR729_RS09030	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FR729_RS09035	COG2832	Protein of unknown function (DUF454)
FR729_RS09040	COG0745	RESPONSE REGULATOR receiver
FR729_RS09045	COG0583	DNA-binding transcription factor activity
FR729_RS09050	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
FR729_RS09055	COG1286	toxin biosynthetic process
FR729_RS09060	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
FR729_RS09065	COG0285	dihydrofolate synthase activity
FR729_RS09070	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FR729_RS09075	COG0101	tRNA pseudouridine synthase activity
FR729_RS09085	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FR729_RS09090	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FR729_RS09095	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FR729_RS09100	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FR729_RS09100	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
FR729_RS09105	COG0431	NADPH-dependent FMN reductase
FR729_RS09115	COG3101	peptidyl-lysine hydroxylation
FR729_RS09120	COG2860	membrane
FR729_RS09125	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FR729_RS09130	COG2890	protein-(glutamine-N5) methyltransferase activity
FR729_RS09135	COG2840	Smr protein MutS2
FR729_RS09140	COG2062	phosphohistidine phosphatase, SixA
FR729_RS09155	COG1250	3-hydroxyacyl-CoA dehydrogenase
FR729_RS09155	COG1024	Enoyl-CoA hydratase
FR729_RS09160	COG0183	Belongs to the thiolase family
FR729_RS09180	COG2067	long-chain fatty acid transport protein
FR729_RS09190	COG3088	subunit of a heme lyase
FR729_RS09190	COG4235	cytochrome complex assembly
FR729_RS09200	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FR729_RS09205	COG1138	Cytochrome C-type biogenesis protein
FR729_RS09210	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
FR729_RS09215	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FR729_RS09220	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FR729_RS09225	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FR729_RS09230	COG4133	protoheme IX ABC transporter activity
FR729_RS09240	COG0835	chemotaxis
FR729_RS09250	COG1192	Involved in chromosome partitioning
FR729_RS09255	COG2201	protein-glutamate methylesterase activity
FR729_RS09260	COG0643	Histidine kinase
FR729_RS09260	COG2198	Histidine kinase
FR729_RS09260	COG0784	Response regulator, receiver
FR729_RS09265	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
FR729_RS09300	COG1684	flagellar biosynthetic protein fliR
FR729_RS09305	COG1987	bacterial-type flagellum assembly
FR729_RS09360	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FR729_RS09370	COG1677	Flagellar hook-basal body complex protein FliE
FR729_RS09380	COG4191	Histidine kinase
FR729_RS09390	COG1516	flagellar protein fliS
FR729_RS09400	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
FR729_RS09405	COG1334	flagellar protein FlaG
FR729_RS09410	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FR729_RS09415	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FR729_RS09420	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FR729_RS09425	COG2837	iron assimilation
FR729_RS09450	COG1393	Belongs to the ArsC family
FR729_RS09455	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FR729_RS09475	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FR729_RS09485	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FR729_RS09500	COG4783	chaperone-mediated protein folding
FR729_RS09505	COG1393	Belongs to the ArsC family
FR729_RS09525	COG2233	PERMEase
FR729_RS09535	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FR729_RS09540	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FR729_RS09545	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FR729_RS09550	COG0121	glutamine amidotransferase
FR729_RS09555	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
FR729_RS09560	COG1960	acyl-CoA dehydrogenase activity
FR729_RS09595	COG0328	RNA-DNA hybrid ribonuclease activity
FR729_RS09600	COG2226	methyltransferase
FR729_RS09605	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FR729_RS09610	COG0741	lytic transglycosylase activity
FR729_RS09610	COG1388	LysM domain
FR729_RS09620	COG3021	interspecies interaction between organisms
FR729_RS09625	COG0347	Belongs to the P(II) protein family
FR729_RS09640	COG0825	malonyl-CoA metabolic process
FR729_RS09645	COG0587	DNA-directed DNA polymerase activity
FR729_RS09655	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FR729_RS09660	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FR729_RS09670	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FR729_RS09675	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
FR729_RS09685	COG0750	zinc metalloprotease
FR729_RS09690	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FR729_RS09695	COG0575	Belongs to the CDS family
FR729_RS09700	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FR729_RS09705	COG0233	cytoplasmic translational termination
FR729_RS09710	COG0528	UMP kinase activity
FR729_RS09715	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FR729_RS09720	COG0052	Belongs to the universal ribosomal protein uS2 family
FR729_RS09725	COG0024	Methionine aminopeptidase
FR729_RS09730	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
FR729_RS09740	COG0564	pseudouridine synthase activity
FR729_RS09745	COG3098	single-species biofilm formation
FR729_RS09775	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FR729_RS09780	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FR729_RS09805	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
FR729_RS09815	COG0254	rRNA binding
FR729_RS09820	COG1720	tRNA m6t6A37 methyltransferase activity
FR729_RS09825	COG0442	prolyl-tRNA aminoacylation
FR729_RS09845	COG0733	neurotransmitter:sodium symporter activity
FR729_RS09865	COG0514	ATP-dependent DNA helicase (RecQ)
FR729_RS09870	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FR729_RS09875	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FR729_RS09905	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FR729_RS09915	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
FR729_RS09930	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FR729_RS09975	COG1477	protein flavinylation
FR729_RS09980	COG2871	sodium ion transport
FR729_RS09985	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FR729_RS09990	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FR729_RS09995	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FR729_RS10000	COG1805	sodium ion transport
FR729_RS10005	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FR729_RS10010	COG0271	Belongs to the BolA IbaG family
FR729_RS10015	COG2813	Specifically methylates the guanine in position
FR729_RS10020	COG3056	Lipoprotein
FR729_RS10040	COG1595	DNA-templated transcription, initiation
FR729_RS10055	COG3248	Nucleoside-binding outer membrane protein
FR729_RS10060	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FR729_RS10065	COG0693	protein deglycase activity
FR729_RS10070	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FR729_RS10075	COG3706	GGDEF domain
FR729_RS10080	COG2166	iron-sulfur cluster assembly
FR729_RS10085	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FR729_RS10090	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
FR729_RS10100	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
FR729_RS10100	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FR729_RS10120	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FR729_RS10125	COG1074	ATP-dependent DNA helicase activity
FR729_RS10130	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
FR729_RS10150	COG3141	response to X-ray
FR729_RS10165	COG2171	N-acyltransferase activity
FR729_RS10170	COG0584	glycerophosphoryl diester phosphodiesterase
FR729_RS10175	COG2271	Major facilitator Superfamily
FR729_RS10180	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FR729_RS10185	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FR729_RS10190	COG1349	DNA-binding transcription factor activity
FR729_RS10195	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FR729_RS10200	COG0598	Magnesium transport protein CorA
FR729_RS10220	COG1609	Transcriptional regulator
FR729_RS10225	COG0583	DNA-binding transcription factor activity
FR729_RS10285	COG4964	Belongs to the GSP D family
FR729_RS10310	COG2169	Transcriptional regulator
FR729_RS10315	COG1022	Amp-dependent synthetase and ligase
FR729_RS10325	COG0583	DNA-binding transcription factor activity
FR729_RS10330	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FR729_RS10335	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FR729_RS10345	COG0560	Phosphoserine phosphatase
FR729_RS10355	COG0813	purine-nucleoside phosphorylase activity
FR729_RS10360	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
FR729_RS10365	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
FR729_RS10370	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FR729_RS10375	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FR729_RS10380	COG0084	hydrolase, TatD family'
FR729_RS10410	COG3153	acetyltransferase
FR729_RS10415	COG3154	lipid carrier protein
FR729_RS10425	COG0826	peptidase U32
FR729_RS10430	COG0826	peptidase U32
FR729_RS10435	COG0534	Mate efflux family protein
FR729_RS10450	COG1185	polyribonucleotide nucleotidyltransferase activity
FR729_RS10455	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FR729_RS10460	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FR729_RS10465	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FR729_RS10470	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FR729_RS10475	COG0195	Participates in both transcription termination and antitermination
FR729_RS10480	COG0779	Required for maturation of 30S ribosomal subunits
FR729_RS10495	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FR729_RS10505	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FR729_RS10510	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FR729_RS10515	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FR729_RS10520	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
FR729_RS10525	COG1534	Rna-binding protein
FR729_RS10530	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FR729_RS10535	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
FR729_RS10540	COG2027	D-alanyl-D-alanine carboxypeptidase
FR729_RS10550	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FR729_RS10555	COG0739	heme binding
FR729_RS10580	COG0628	permease
FR729_RS10590	COG0784	Response regulator, receiver
FR729_RS10590	COG2205	protein histidine kinase activity
FR729_RS10595	COG0747	negative chemotaxis
FR729_RS10605	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FR729_RS10610	COG0444	Belongs to the ABC transporter superfamily
FR729_RS10615	COG4608	Belongs to the ABC transporter superfamily
FR729_RS10625	COG2971	BadF BadG BcrA BcrD
FR729_RS10640	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FR729_RS10645	COG3842	ATPase activity
FR729_RS10655	COG1840	ABC-type Fe3 transport system, periplasmic component
FR729_RS10660	COG0004	ammonium transporteR
FR729_RS10670	COG3112	Uncharacterised protein family (UPF0231)
FR729_RS10675	COG1049	propionate catabolic process, 2-methylcitrate cycle
FR729_RS10680	COG1752	Esterase of the alpha-beta hydrolase superfamily
FR729_RS10685	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FR729_RS10690	COG1643	Atp-dependent helicase
FR729_RS10695	COG1489	DNA binding
FR729_RS10705	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FR729_RS10715	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FR729_RS10720	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FR729_RS10725	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FR729_RS10730	COG1560	Kdo2-lipid A biosynthetic process
FR729_RS10735	COG0842	Transport permease protein
FR729_RS10740	COG1131	(ABC) transporter
FR729_RS10745	COG0659	secondary active sulfate transmembrane transporter activity
FR729_RS10750	COG0288	reversible hydration of carbon dioxide
FR729_RS10765	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FR729_RS10770	COG0508	dehydrogenase complex catalyzes the overall conversion of
FR729_RS10775	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
FR729_RS10780	COG2186	Transcriptional regulator
FR729_RS10790	COG0157	Belongs to the NadC ModD family
FR729_RS10800	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FR729_RS10805	COG1459	type II secretion system
FR729_RS10815	COG0237	dephospho-CoA kinase activity
FR729_RS10820	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
FR729_RS10825	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
FR729_RS10840	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FR729_RS10845	COG0228	four-way junction DNA binding
FR729_RS10850	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FR729_RS10855	COG4137	Cytochrome C assembly protein
FR729_RS10860	COG4536	flavin adenine dinucleotide binding
FR729_RS10865	COG1854	S-ribosylhomocysteine lyase activity
FR729_RS10880	COG0612	Peptidase, M16
FR729_RS10885	COG1238	metal cluster binding
FR729_RS10895	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
FR729_RS10900	COG0511	ligase activity, forming carbon-carbon bonds
FR729_RS10900	COG5016	pyruvate
FR729_RS10905	COG3630	sodium ion export across plasma membrane
FR729_RS10965	COG0527	aspartate kinase activity
FR729_RS10970	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FR729_RS10975	COG2137	regulation of response to DNA damage stimulus
FR729_RS10980	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FR729_RS10985	COG1546	Belongs to the CinA family
FR729_RS10990	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FR729_RS10995	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FR729_RS11005	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FR729_RS11010	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FR729_RS11020	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FR729_RS11025	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FR729_RS11030	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
FR729_RS11035	COG0148	phosphopyruvate hydratase activity
FR729_RS11040	COG0504	CTP synthase activity
FR729_RS11045	COG3956	TIGRFAM MazG family protein
FR729_RS11050	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FR729_RS11055	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FR729_RS11065	COG0736	holo-[acyl-carrier-protein] synthase activity
FR729_RS11070	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FR729_RS11075	COG1381	Involved in DNA repair and RecF pathway recombination
FR729_RS11080	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FR729_RS11090	COG0681	Belongs to the peptidase S26 family
FR729_RS11095	COG0481	GTPase activity
FR729_RS11100	COG3086	response to oxidative stress
FR729_RS11115	COG1595	DNA-templated transcription, initiation
FR729_RS11120	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
FR729_RS11130	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
FR729_RS11150	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FR729_RS11155	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FR729_RS11160	COG3079	Belongs to the UPF0149 family
FR729_RS11165	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
FR729_RS11175	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FR729_RS11180	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FR729_RS11185	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FR729_RS11195	COG0583	DNA-binding transcription factor activity
FR729_RS11210	COG0668	transmembrane transport
FR729_RS11215	COG0191	fructose-bisphosphate aldolase activity
FR729_RS11230	COG4771	TonB-dependent receptor
FR729_RS11235	COG0583	DNA-binding transcription factor activity
FR729_RS11240	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FR729_RS11245	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FR729_RS11260	COG2356	endonuclease I
FR729_RS11265	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FR729_RS11270	COG0189	ligase activity
FR729_RS11275	COG1678	Uncharacterized ACR, COG1678
FR729_RS11280	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FR729_RS11295	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FR729_RS11300	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FR729_RS11305	COG0762	integral membrane protein
FR729_RS11310	COG1872	DUF167
FR729_RS11320	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FR729_RS11325	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FR729_RS11330	COG2066	Belongs to the glutaminase family
FR729_RS11340	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FR729_RS11350	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
FR729_RS11470	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
FR729_RS11480	COG3394	polysaccharide catabolic process
FR729_RS11485	COG1486	melibiose metabolic process
FR729_RS11490	COG1447	Phosphotransferase system cellobiose-specific component IIA
FR729_RS11495	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FR729_RS11500	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FR729_RS11505	COG0726	polysaccharide deacetylase
FR729_RS11610	COG1028	Short-chain dehydrogenase reductase Sdr
FR729_RS11625	COG0795	lipopolysaccharide-transporting ATPase activity
FR729_RS11630	COG0795	lipopolysaccharide-transporting ATPase activity
FR729_RS11635	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FR729_RS11640	COG2927	DNA polymerase III (CHI subunit)
FR729_RS11645	COG0525	valine-tRNA ligase activity
FR729_RS11655	COG0456	acetyltransferase
FR729_RS11685	COG0540	Belongs to the ATCase OTCase family
FR729_RS11690	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
FR729_RS11695	COG0251	oxidation-reduction process
FR729_RS11700	COG0204	Acyl-transferase
FR729_RS11705	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FR729_RS11710	COG5007	Belongs to the BolA IbaG family
FR729_RS11720	COG2854	intermembrane phospholipid transfer
FR729_RS11725	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FR729_RS11730	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FR729_RS11735	COG1127	ABC transporter
FR729_RS11745	COG0517	IMP dehydrogenase activity
FR729_RS11745	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FR729_RS11755	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
FR729_RS11760	COG1137	ATPase activity
FR729_RS11770	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FR729_RS11775	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FR729_RS11780	COG1660	Displays ATPase and GTPase activities
FR729_RS11785	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FR729_RS11790	COG2239	Acts as a magnesium transporter
FR729_RS11795	COG0312	modulator of DNA gyrase
FR729_RS11800	COG3028	Belongs to the UPF0307 family
FR729_RS11805	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FR729_RS11810	COG0564	pseudouridine synthase activity
FR729_RS11820	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FR729_RS11825	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
FR729_RS11830	COG0312	modulator of DNA gyrase
FR729_RS11835	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FR729_RS11840	COG3164	Protein of unknown function
FR729_RS11845	COG1530	ribonuclease E activity
FR729_RS11850	COG0424	maF-like protein
FR729_RS11855	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
FR729_RS11860	COG1792	Involved in formation and maintenance of cell shape
FR729_RS11865	COG1077	Cell shape determining protein MreB Mrl
FR729_RS11910	COG1459	type II secretion system
FR729_RS11915	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FR729_RS11925	COG3409	Peptidoglycan-binding domain 1 protein
FR729_RS11925	COG3267	Type II secretory pathway component ExeA
FR729_RS11930	COG1450	Type ii and iii secretion system protein
FR729_RS11950	COG2200	EAL domain
FR729_RS11950	COG2199	diguanylate cyclase activity
FR729_RS11955	COG0629	single-stranded DNA binding
FR729_RS11970	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FR729_RS11980	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FR729_RS11985	COG0527	aspartate kinase activity
FR729_RS11990	COG1410	methionine synthase
FR729_RS11990	COG0646	methionine synthase
FR729_RS12050	COG0175	sulfate reduction
FR729_RS12055	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FR729_RS12060	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FR729_RS12080	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FR729_RS12085	COG0735	belongs to the Fur family
FR729_RS12095	COG0166	Belongs to the GPI family
FR729_RS12100	COG0432	Pfam Uncharacterised protein family UPF0047
FR729_RS12105	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FR729_RS12130	COG2965	DNA replication, synthesis of RNA primer
FR729_RS12135	COG0360	Binds together with S18 to 16S ribosomal RNA
FR729_RS12140	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FR729_RS12145	COG0338	D12 class N6 adenine-specific DNA methyltransferase
FR729_RS12155	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FR729_RS12160	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FR729_RS12190	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FR729_RS12200	COG0678	peroxiredoxin activity
FR729_RS12200	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FR729_RS12205	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FR729_RS12215	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
FR729_RS12215	COG0165	Argininosuccinate lyase
FR729_RS12220	COG0137	argininosuccinate synthase activity
FR729_RS12230	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FR729_RS12240	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
FR729_RS12250	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FR729_RS12255	COG0460	homoserine dehydrogenase
FR729_RS12255	COG0527	aspartate kinase activity
FR729_RS12260	COG0626	cystathionine gamma-synthase activity
FR729_RS12270	COG0281	malic enzyme
FR729_RS12285	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FR729_RS12290	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FR729_RS12310	COG2923	Belongs to the DsrF TusC family
FR729_RS12315	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
FR729_RS12320	COG2964	Protein conserved in bacteria
FR729_RS12325	COG0545	Peptidyl-prolyl cis-trans isomerase
FR729_RS12340	COG1446	asparaginase
FR729_RS12345	COG1047	Peptidyl-prolyl cis-trans
FR729_RS12360	COG2249	NAD(P)H dehydrogenase (quinone) activity
FR729_RS12365	COG0488	(ABC) transporter
FR729_RS12375	COG0429	hydrolase of the alpha beta-hydrolase fold
FR729_RS12385	COG3954	Phosphoribulokinase
FR729_RS12390	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FR729_RS12410	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FR729_RS12415	COG0512	Glutamine amidotransferase of anthranilate synthase
FR729_RS12430	COG0180	Tryptophanyl-tRNA synthetase
FR729_RS12435	COG0546	phosphoglycolate phosphatase activity
FR729_RS12440	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FR729_RS12445	COG0557	exoribonuclease II activity
FR729_RS12450	COG1959	2 iron, 2 sulfur cluster binding
FR729_RS12455	COG1017	nitric oxide dioxygenase activity
FR729_RS12455	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FR729_RS12460	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
FR729_RS12465	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FR729_RS12470	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
FR729_RS12475	COG0330	HflC and HflK could
FR729_RS12480	COG0330	HflC and HflK could
FR729_RS12485	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FR729_RS12495	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FR729_RS12500	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FR729_RS12510	COG0802	atpase or kinase
FR729_RS12515	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FR729_RS12580	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
FR729_RS12585	COG1162	GTPase activity
FR729_RS12590	COG0688	phosphatidylethanolamine metabolic process
FR729_RS12595	COG0471	metal ion transport
FR729_RS12595	COG3273	potassium ion transport
FR729_RS12605	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FR729_RS12610	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FR729_RS12615	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
FR729_RS12620	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FR729_RS12625	COG1045	serine acetyltransferase
FR729_RS12630	COG4942	peptidase
FR729_RS12650	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
FR729_RS12655	COG1053	succinate dehydrogenase
FR729_RS12660	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FR729_RS12665	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
FR729_RS12670	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
FR729_RS12685	COG1509	lysine 2,3-aminomutase activity
FR729_RS12690	COG1285	pathogenesis
FR729_RS12700	COG0459	protein refolding
FR729_RS12710	COG0534	Mate efflux family protein
FR729_RS12715	COG0205	6-phosphofructokinase activity
FR729_RS12725	COG3678	ATP-independent chaperone mediated protein folding
FR729_RS12730	COG0745	RESPONSE REGULATOR receiver
FR729_RS12735	COG2205	protein histidine kinase activity
FR729_RS12745	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FR729_RS12750	COG3030	protein affecting phage T7 exclusion by the F plasmid
FR729_RS12755	COG1027	Aspartate ammonia-lyase
FR729_RS12760	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
FR729_RS12765	COG4232	protein-disulfide reductase activity
FR729_RS12775	COG3263	regulation of cellular component size
FR729_RS12785	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FR729_RS12810	COG2814	Major facilitator Superfamily
FR729_RS12825	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FR729_RS12830	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FR729_RS12835	COG0511	ligase activity, forming carbon-carbon bonds
FR729_RS12840	COG0439	Biotin carboxylase
FR729_RS12845	COG2264	protein methyltransferase activity
FR729_RS12850	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FR729_RS12855	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
FR729_RS12865	COG0488	(ABC) transporter
FR729_RS12925	COG1982	Orn Lys Arg decarboxylase major
FR729_RS12930	COG0531	amino acid
FR729_RS12935	COG3710	Transcriptional regulator
FR729_RS12940	COG0789	Transcriptional regulator
FR729_RS12950	COG0151	Belongs to the GarS family
FR729_RS12965	COG1253	flavin adenine dinucleotide binding
FR729_RS12970	COG3068	Protein conserved in bacteria
FR729_RS12980	COG1573	uracil-dna glycosylase
FR729_RS12985	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FR729_RS12990	COG2816	NAD+ diphosphatase activity
FR729_RS12995	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
FR729_RS13000	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FR729_RS13005	COG0085	RNA polymerase activity
FR729_RS13010	COG0222	ribosome binding
FR729_RS13015	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FR729_RS13030	COG0250	Participates in transcription elongation, termination and antitermination
FR729_RS13035	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FR729_RS13040	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FR729_RS13070	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
FR729_RS13070	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
FR729_RS13075	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FR729_RS13085	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FR729_RS13125	COG4206	TonB-dependent receptor
FR729_RS13155	COG0739	heme binding
FR729_RS13170	COG3547	Transposase (IS116 IS110 IS902 family)
FR729_RS13300	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FR729_RS13305	COG0534	Mate efflux family protein
FR729_RS13310	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
FR729_RS13315	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FR729_RS13320	COG2937	Belongs to the GPAT DAPAT family
FR729_RS13325	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FR729_RS13330	COG3161	chorismate lyase activity
FR729_RS13335	COG1580	Controls the rotational direction of flagella during chemotaxis
FR729_RS13340	COG0705	Rhomboid family
FR729_RS13345	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FR729_RS13355	COG2177	Part of the ABC transporter FtsEX involved in
FR729_RS13360	COG2884	Cell division ATP-binding protein ftsE
FR729_RS13365	COG0552	protein localization to endoplasmic reticulum
FR729_RS13370	COG0742	ribosomal rna small subunit methyltransferase
FR729_RS13380	COG2095	MarC family integral membrane protein
FR729_RS13425	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FR729_RS13430	COG0640	Transcriptional regulator
FR729_RS13435	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
FR729_RS13440	COG1280	lysine exporter protein (LysE YggA)
FR729_RS13445	COG2267	carboxylic ester hydrolase activity
FR729_RS13450	COG0561	phosphatase activity
FR729_RS13470	COG2200	EAL domain
FR729_RS13470	COG2199	diguanylate cyclase activity
FR729_RS13470	COG3287	FIST C domain
FR729_RS13475	COG1011	Hydrolase
FR729_RS13480	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
FR729_RS13495	COG0019	diaminopimelate decarboxylase activity
FR729_RS13505	COG1965	Belongs to the frataxin family
FR729_RS13510	COG3072	Adenylate cyclase
FR729_RS13515	COG0181	hydroxymethylbilane synthase activity
FR729_RS13520	COG1587	Uroporphyrinogen-III synthase
FR729_RS13525	COG2959	enzyme of heme biosynthesis
FR729_RS13530	COG3071	HemY protein
FR729_RS13570	COG0633	Ferredoxin
FR729_RS13575	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
FR729_RS13590	COG3118	belongs to the thioredoxin family
FR729_RS13595	COG0513	Belongs to the DEAD box helicase family
FR729_RS13610	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
FR729_RS13620	COG0514	ATP-dependent DNA helicase (RecQ)
FR729_RS13625	COG2962	Rard protein
FR729_RS13635	COG1280	lysine exporter protein (LysE YggA)
FR729_RS13640	COG0405	Gamma-glutamyltransferase
FR729_RS13645	COG0210	DNA helicase
FR729_RS13655	COG3220	belongs to the UPF0276 family
FR729_RS13685	COG0006	proline dipeptidase activity
FR729_RS13685	COG0006	proline dipeptidase activity
FR729_RS13700	COG2104	thiamine diphosphate biosynthetic process
FR729_RS13705	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FR729_RS13725	COG2132	Multicopper oxidase
FR729_RS13775	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FR729_RS13780	COG1739	Uncharacterized protein family UPF0029
FR729_RS13790	COG0183	Belongs to the thiolase family
FR729_RS13795	COG0604	alcohol dehydrogenase
FR729_RS13810	COG0425	Belongs to the sulfur carrier protein TusA family
FR729_RS13820	COG2119	membrane
FR729_RS13835	COG0366	Alpha amylase catalytic
FR729_RS13840	COG3977	Valine--pyruvate aminotransferase
FR729_RS13845	COG0071	Belongs to the small heat shock protein (HSP20) family
FR729_RS13855	COG0187	DNA topoisomerase II activity
FR729_RS13865	COG0592	DNA-directed DNA polymerase activity
FR729_RS13870	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FR729_RS13885	COG1126	abc transporter atp-binding protein
FR729_RS13895	COG0594	ribonuclease P activity
FR729_RS13905	COG0706	membrane insertase activity
FR729_RS13915	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FR729_RS13920	COG0445	tRNA wobble uridine modification
FR729_RS13925	COG0357	Ribosomal RNA small subunit methyltransferase G
FR729_RS13930	COG1192	Involved in chromosome partitioning
FR729_RS13935	COG1475	DNA binding
FR729_RS13940	COG3312	ion transport
FR729_RS13945	COG0356	it plays a direct role in the translocation of protons across the membrane
FR729_RS13955	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FR729_RS13960	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FR729_RS13965	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FR729_RS13970	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FR729_RS13975	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FR729_RS13980	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FR729_RS13990	COG0765	amino acid transport
FR729_RS14000	COG2814	Major facilitator Superfamily
FR729_RS14005	COG0583	DNA-binding transcription factor activity
FR729_RS14015	COG0129	dihydroxy-acid dehydratase activity
FR729_RS14020	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FR729_RS14025	COG3978	acetolactate synthase activity
FR729_RS14035	COG0606	chelatase, subunit chli
FR729_RS14045	COG0204	Acyl-transferase
FR729_RS14050	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FR729_RS14055	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
FR729_RS14065	COG3084	Protein conserved in bacteria
FR729_RS14075	COG4326	sporulation control protein
FR729_RS14080	COG1272	protein, Hemolysin III
FR729_RS14090	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FR729_RS14095	COG0569	domain protein
FR729_RS14100	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FR729_RS14100	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FR729_RS14105	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FR729_RS14110	COG0242	peptide deformylase activity
FR729_RS14120	COG0758	DNA mediated transformation
FR729_RS14125	COG2922	Belongs to the Smg family
FR729_RS14130	COG0551	DNA topoisomerase type I activity
FR729_RS14135	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FR729_RS14140	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FR729_RS14145	COG0009	L-threonylcarbamoyladenylate synthase
FR729_RS14165	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FR729_RS14200	COG0583	DNA-binding transcription factor activity
FR729_RS14205	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FR729_RS14210	COG2960	long-chain fatty acid transporting porin activity
FR729_RS14215	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FR729_RS14220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FR729_RS14275	COG4166	transmembrane transport
FR729_RS14285	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FR729_RS14320	COG1609	Transcriptional regulator
FR729_RS14325	COG0583	DNA-binding transcription factor activity
FR729_RS14340	COG0129	dihydroxy-acid dehydratase activity
FR729_RS14345	COG3265	gluconokinase activity
FR729_RS14350	COG2610	gluconate transmembrane transporter activity
FR729_RS14355	COG0800	Aldolase
FR729_RS14360	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
FR729_RS14365	COG0583	DNA-binding transcription factor activity
FR729_RS14370	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FR729_RS14375	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
FR729_RS14385	COG1522	sequence-specific DNA binding
FR729_RS14390	COG5002	protein histidine kinase activity
FR729_RS14390	COG5001	Diguanylate cyclase
FR729_RS14395	COG0742	ribosomal rna small subunit methyltransferase
FR729_RS14410	COG0589	response to stress
FR729_RS14415	COG1528	Iron-storage protein
FR729_RS14455	COG2081	HI0933 family
FR729_RS14510	COG0210	DNA helicase
FR729_RS14565	COG1597	lipid kinase activity
FR729_RS14595	COG0628	permease
FR729_RS14610	COG1322	Protein conserved in bacteria
FR729_RS14615	COG2226	methyltransferase
FR729_RS14620	COG3165	ubiquinone biosynthetic process from chorismate
FR729_RS14625	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FR729_RS14635	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FR729_RS14640	COG0805	protein transport
FR729_RS14645	COG0084	hydrolase, TatD family'
FR729_RS14655	COG0456	acetyltransferase
FR729_RS14660	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FR729_RS14660	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FR729_RS14665	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FR729_RS14695	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FR729_RS14705	COG2204	response regulator
FR729_RS14710	COG3852	Histidine kinase
FR729_RS14720	COG0174	glutamine synthetase
FR729_RS14730	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FR729_RS14740	COG1295	ribonuclease BN
FR729_RS14745	COG1490	D-aminoacyl-tRNA deacylase activity
FR729_RS14750	COG0456	acetyltransferase
FR729_RS14760	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
FR729_RS14765	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
FR729_RS14770	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FR729_RS14775	COG3031	protein transport across the cell outer membrane
FR729_RS14785	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FR729_RS14790	COG1459	type II secretion system
FR729_RS14795	COG2165	general secretion pathway protein
FR729_RS14800	COG2165	general secretion pathway protein
FR729_RS14805	COG2165	general secretion pathway protein
FR729_RS14810	COG4795	General secretion pathway protein
FR729_RS14815	COG3156	type II secretion system protein K
FR729_RS14820	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
FR729_RS14825	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
FR729_RS14835	COG1218	3'(2'),5'-bisphosphate nucleotidase
FR729_RS14840	COG0494	nUDIX hydrolase
FR729_RS14850	COG1040	competence protein
FR729_RS14865	COG2183	response to ionizing radiation
FR729_RS14875	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FR729_RS14885	COG0745	RESPONSE REGULATOR receiver
FR729_RS14895	COG2233	PERMEase
FR729_RS14900	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FR729_RS14905	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FR729_RS14910	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FR729_RS14915	COG1758	RNA polymerase activity
FR729_RS14920	COG0194	GDP metabolic process
FR729_RS14935	COG0848	biopolymer transport protein
FR729_RS14940	COG0811	peptide transport
FR729_RS14960	COG4174	ABC transporter (Permease)
FR729_RS14965	COG4239	(ABC) transporter, permease
FR729_RS14970	COG0747	negative chemotaxis
FR729_RS14975	COG0444	Belongs to the ABC transporter superfamily
FR729_RS14980	COG4608	Belongs to the ABC transporter superfamily
FR729_RS15020	COG2003	Belongs to the UPF0758 family
FR729_RS15025	COG0328	RNA-DNA hybrid ribonuclease activity
FR729_RS15035	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
FR729_RS15065	COG1561	YicC-like family, N-terminal region
FR729_RS15070	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FR729_RS15080	COG1560	Kdo2-lipid A biosynthetic process
FR729_RS15085	COG1309	transcriptional regulator
FR729_RS15090	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FR729_RS15095	COG0840	transmembrane signaling receptor activity
FR729_RS15100	COG2003	Belongs to the UPF0758 family
FR729_RS15125	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FR729_RS15140	COG0463	Glycosyl transferase, family 2
FR729_RS15145	COG0859	PFAM glycosyl transferase family 9
FR729_RS15150	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FR729_RS15155	COG3642	lipopolysaccharide core region biosynthetic process
FR729_RS15165	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
FR729_RS15205	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FR729_RS15210	COG1519	Transferase
FR729_RS15215	COG0859	PFAM glycosyl transferase family 9
FR729_RS15225	COG1560	Kdo2-lipid A biosynthetic process
FR729_RS15235	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FR729_RS15300	COG1215	transferase activity, transferring glycosyl groups
FR729_RS15305	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FR729_RS15310	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
FR729_RS15315	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FR729_RS15335	COG0438	transferase activity, transferring glycosyl groups
FR729_RS15375	COG0149	triose-phosphate isomerase activity
FR729_RS15405	COG1494	fructose-1,6-bisphosphatase
FR729_RS15415	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FR729_RS15420	COG1575	Belongs to the MenA family. Type 1 subfamily
FR729_RS15425	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
FR729_RS15430	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
FR729_RS15440	COG1609	Transcriptional regulator
FR729_RS15445	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FR729_RS15450	COG0254	rRNA binding
FR729_RS15460	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FR729_RS15465	COG0088	Forms part of the polypeptide exit tunnel
FR729_RS15475	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FR729_RS15480	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FR729_RS15485	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FR729_RS15490	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FR729_RS15500	COG0255	Belongs to the universal ribosomal protein uL29 family
FR729_RS15505	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FR729_RS15515	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FR729_RS15520	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FR729_RS15530	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FR729_RS15535	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FR729_RS15550	COG1841	ribosomal large subunit assembly
FR729_RS15560	COG0201	protein transport
FR729_RS15565	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FR729_RS15570	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FR729_RS15575	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FR729_RS15585	COG0202	RNA polymerase activity
FR729_RS15590	COG0203	ribosomal protein L17
FR729_RS15600	COG0545	Peptidyl-prolyl cis-trans isomerase
FR729_RS15610	COG2153	protein acetylation
FR729_RS15615	COG0513	Belongs to the DEAD box helicase family
FR729_RS15630	COG1648	precorrin-2 dehydrogenase activity
FR729_RS15630	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FR729_RS15635	COG0175	sulfate reduction
FR729_RS15640	COG2895	sulfate adenylyltransferase (ATP) activity
FR729_RS15645	COG0471	metal ion transport
FR729_RS15645	COG3273	potassium ion transport
FR729_RS15650	COG0529	Catalyzes the synthesis of activated sulfate
FR729_RS15670	COG4181	ATPase activity
FR729_RS15685	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
FR729_RS15695	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FR729_RS15700	COG0729	surface antigen
FR729_RS15705	COG2911	Protein conserved in bacteria
FR729_RS15710	COG2105	PFAM AIG2 family protein
FR729_RS15720	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FR729_RS15725	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
FR729_RS15730	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FR729_RS15735	COG0163	prenyltransferase activity
FR729_RS15745	COG1178	ABC-type Fe3 transport system permease component
FR729_RS15750	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
FR729_RS15755	COG0583	DNA-binding transcription factor activity
FR729_RS15760	COG1902	pentaerythritol trinitrate reductase activity
FR729_RS15775	COG2358	TRAP transporter, solute receptor (TAXI family
FR729_RS15795	COG0142	geranyltranstransferase activity
FR729_RS15800	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FR729_RS15810	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FR729_RS15815	COG2966	Psort location CytoplasmicMembrane, score
FR729_RS15830	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FR729_RS15835	COG2967	ApaG domain
FR729_RS15840	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FR729_RS15845	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FR729_RS15850	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FR729_RS15855	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
FR729_RS15860	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
FR729_RS15880	COG0473	3-isopropylmalate dehydrogenase activity
FR729_RS15885	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FR729_RS15905	COG0583	DNA-binding transcription factor activity
FR729_RS15910	COG1022	Amp-dependent synthetase and ligase
FR729_RS15915	COG0028	Belongs to the TPP enzyme family
FR729_RS15920	COG0440	acetolactate synthase activity
FR729_RS15925	COG3706	GGDEF domain
FR729_RS15935	COG0469	pyruvate kinase activity
FR729_RS15940	COG1349	DNA-binding transcription factor activity
FR729_RS15945	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FR729_RS15955	COG2376	Dihydroxyacetone kinase
FR729_RS15960	COG1461	Dihydroxyacetone kinase
FR729_RS15975	COG3722	fumarate hydratase activity
FR729_RS15985	COG2213	PTS system mannitol-specific
FR729_RS15985	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FR729_RS16040	COG1902	pentaerythritol trinitrate reductase activity
FR729_RS16045	COG1063	alcohol dehydrogenase
FR729_RS16055	COG1028	Short-chain dehydrogenase reductase Sdr
FR729_RS16065	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FR729_RS16070	COG0006	proline dipeptidase activity
FR729_RS16075	COG3608	succinylglutamate desuccinylase aspartoacylase
FR729_RS16080	COG1522	sequence-specific DNA binding
FR729_RS16085	COG1012	belongs to the aldehyde dehydrogenase family
FR729_RS16090	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FR729_RS16095	COG3122	Protein conserved in bacteria
FR729_RS16110	COG0583	DNA-binding transcription factor activity
FR729_RS16120	COG0252	asparaginase activity
FR729_RS16125	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
FR729_RS16140	COG2197	response regulator
FR729_RS16145	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FR729_RS16170	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FR729_RS16200	COG3842	ATPase activity
FR729_RS16245	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FR729_RS16250	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FR729_RS16280	COG0583	DNA-binding transcription factor activity
FR729_RS16290	COG4948	Mandelate Racemase Muconate Lactonizing
FR729_RS16320	COG1342	Belongs to the UPF0251 family
FR729_RS16325	COG4176	ABC-type proline glycine betaine transport system permease component
FR729_RS16330	COG4175	Glycine betaine
FR729_RS16330	COG3448	diguanylate cyclase activity
FR729_RS16335	COG3015	lipoprotein NlpE involved in copper resistance
FR729_RS16340	COG3713	MltA-interacting MipA family protein
FR729_RS16355	COG0583	DNA-binding transcription factor activity
FR729_RS16380	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
FR729_RS16390	COG1335	isochorismatase
FR729_RS16405	COG1349	DNA-binding transcription factor activity
FR729_RS16410	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FR729_RS16410	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FR729_RS16415	COG2070	2-Nitropropane dioxygenase
FR729_RS16420	COG0531	amino acid
FR729_RS16425	COG4302	ethanolamine ammonia-lyase activity
FR729_RS16430	COG4303	Ethanolamine ammonia lyase large subunit
FR729_RS16440	COG1309	transcriptional regulator
FR729_RS16460	COG1280	lysine exporter protein (LysE YggA)
FR729_RS16470	COG0459	protein refolding
FR729_RS16475	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FR729_RS16480	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FR729_RS16495	COG1304	FMN binding
FR729_RS16520	COG4786	Flagellar basal body rod
FR729_RS16520	COG1256	bacterial-type flagellum assembly
FR729_RS16530	COG1706	bacterial-type flagellum-dependent cell motility
FR729_RS16535	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
FR729_RS16540	COG4786	Flagellar basal body rod
FR729_RS16545	COG4787	bacterial-type flagellum-dependent cell motility
FR729_RS16560	COG1558	bacterial-type flagellum-dependent cell motility
FR729_RS16565	COG1815	bacterial-type flagellum-dependent cell motility
FR729_RS16585	COG0741	lytic transglycosylase activity
FR729_RS16590	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FR729_RS16610	COG1760	l-serine dehydratase
FR729_RS16625	COG0583	DNA-binding transcription factor activity
FR729_RS16635	COG2866	Carboxypeptidase
FR729_RS16640	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FR729_RS16650	COG2990	Protein conserved in bacteria
FR729_RS16675	COG3842	ATPase activity
FR729_RS16680	COG1840	ABC-type Fe3 transport system, periplasmic component
FR729_RS16700	COG1609	Transcriptional regulator
FR729_RS16730	COG3240	lipase activity
FR729_RS16735	COG1309	transcriptional regulator
FR729_RS16750	COG0577	efflux transmembrane transporter activity
FR729_RS16750	COG1136	(ABC) transporter
FR729_RS16755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FR729_RS16760	COG2067	long-chain fatty acid transport protein
FR729_RS16770	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
FR729_RS16785	COG1011	Hydrolase
FR729_RS16825	COG0110	maltose O-acetyltransferase activity
FR729_RS16830	COG1765	OsmC-like protein
FR729_RS16835	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FR729_RS16835	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FR729_RS16850	COG3046	protein related to deoxyribodipyrimidine photolyase
FR729_RS16855	COG0415	Belongs to the DNA photolyase family
FR729_RS16860	COG3706	GGDEF domain
FR729_RS16875	COG3706	GGDEF domain
FR729_RS16890	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FR729_RS16910	COG3033	Beta-eliminating lyase
FR729_RS16920	COG1271	oxidase subunit
FR729_RS16925	COG1294	oxidase, subunit
FR729_RS16940	COG0579	oxidoreductase
FR729_RS16960	COG3706	GGDEF domain
FR729_RS16970	COG4191	Histidine kinase
FR729_RS16995	COG0583	DNA-binding transcription factor activity
FR729_RS17015	COG0189	ligase activity
FR729_RS17020	COG0189	ligase activity
FR729_RS17020	COG4067	protein conserved in archaea
FR729_RS17030	COG1166	arginine decarboxylase activity
FR729_RS17035	COG0010	Belongs to the arginase family
FR729_RS17040	COG2814	Major facilitator Superfamily
FR729_RS17045	COG1770	oligopeptidase
FR729_RS17060	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FR729_RS17065	COG1121	(ABC) transporter
FR729_RS17070	COG0803	Belongs to the bacterial solute-binding protein 9 family
FR729_RS17110	COG0848	biopolymer transport protein
FR729_RS17115	COG0811	peptide transport
FR729_RS17120	COG0811	peptide transport
FR729_RS17140	COG0745	RESPONSE REGULATOR receiver
FR729_RS17145	COG0584	glycerophosphoryl diester phosphodiesterase
FR729_RS17215	COG1901	pseudouridine methyltransferase
FR729_RS17220	COG0312	modulator of DNA gyrase
FR729_RS17230	COG0351	phosphomethylpyrimidine kinase
FR729_RS17235	COG1116	anion transmembrane transporter activity
FR729_RS17240	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FR729_RS17245	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FR729_RS17250	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
FR729_RS17270	COG0243	molybdopterin cofactor binding
FR729_RS17275	COG3005	denitrification pathway
FR729_RS17280	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FR729_RS17285	COG1028	Short-chain dehydrogenase reductase Sdr
FR729_RS17300	COG0456	acetyltransferase
FR729_RS17320	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FR729_RS17325	COG1929	Belongs to the glycerate kinase type-1 family
FR729_RS17330	COG2610	gluconate transmembrane transporter activity
FR729_RS17335	COG3835	regulator
FR729_RS17395	COG3047	cAMP biosynthetic process
FR729_RS17400	COG1357	PFAM Pentapeptide repeats (8 copies)
FR729_RS17430	COG2375	cellular response to nickel ion
FR729_RS17435	COG0583	DNA-binding transcription factor activity
FR729_RS17440	COG2162	N-hydroxyarylamine O-acetyltransferase activity
FR729_RS17445	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
FR729_RS17460	COG2199	diguanylate cyclase activity
FR729_RS17470	COG0561	phosphatase activity
FR729_RS17475	COG0583	DNA-binding transcription factor activity
FR729_RS17490	COG0564	pseudouridine synthase activity
FR729_RS17495	COG0534	Mate efflux family protein
FR729_RS17510	COG3123	guanosine phosphorylase activity
FR729_RS17525	COG0596	Alpha beta hydrolase
FR729_RS17550	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FR729_RS17560	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FR729_RS17565	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FR729_RS17565	COG2169	Transcriptional regulator
FR729_RS17575	COG2259	Doxx family
FR729_RS17580	COG1741	Belongs to the pirin family
FR729_RS17600	COG0363	glucosamine-6-phosphate deaminase activity
FR729_RS17610	COG0786	glutamate:sodium symporter activity
FR729_RS17615	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FR729_RS17620	COG1131	(ABC) transporter
FR729_RS17630	COG0786	glutamate:sodium symporter activity
FR729_RS17650	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FR729_RS17660	COG3279	Response regulator of the LytR AlgR family
FR729_RS17665	COG3275	phosphorelay sensor kinase activity
FR729_RS17685	COG1136	(ABC) transporter
FR729_RS17695	COG0772	Belongs to the SEDS family
FR729_RS17720	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
FR729_RS17720	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FR729_RS17730	COG0444	Belongs to the ABC transporter superfamily
FR729_RS17735	COG4608	Belongs to the ABC transporter superfamily
FR729_RS17760	COG1444	tRNA N-acetyltransferase activity
FR729_RS17780	COG3340	Belongs to the peptidase S51 family
FR729_RS17785	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
FR729_RS17790	COG1263	PTS System
FR729_RS17790	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FR729_RS17795	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
FR729_RS17810	COG4166	transmembrane transport
FR729_RS17860	COG0259	pyridoxamine-phosphate oxidase activity
FR729_RS17885	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FR729_RS17925	COG1132	(ABC) transporter
FR729_RS17935	COG0513	Belongs to the DEAD box helicase family
FR729_RS17940	COG2258	MOSC domain
FR729_RS17990	COG3634	alkyl hydroperoxide reductase activity
FR729_RS18000	COG1846	Transcriptional regulator
FR729_RS18005	COG1764	response to oxidative stress
FR729_RS18045	COG1136	(ABC) transporter
FR729_RS18060	COG0463	Glycosyl transferase, family 2
FR729_RS18095	COG0745	RESPONSE REGULATOR receiver
FR729_RS18105	COG1653	transport
FR729_RS18110	COG0019	diaminopimelate decarboxylase activity
FR729_RS18115	COG4264	IucA IucC family
FR729_RS18140	COG4772	TonB-dependent receptor
FR729_RS18145	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
FR729_RS18150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FR729_RS18155	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FR729_RS18160	COG1120	ATPase activity
FR729_RS18165	COG0840	transmembrane signaling receptor activity
FR729_RS18170	COG0612	Peptidase, M16
FR729_RS18180	COG0739	heme binding
FR729_RS18195	COG2814	Major facilitator Superfamily
FR729_RS18205	COG1609	Transcriptional regulator
FR729_RS18210	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FR729_RS18235	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FR729_RS18240	COG1609	Transcriptional regulator
FR729_RS18250	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FR729_RS18290	COG1760	l-serine dehydratase
FR729_RS18300	COG4580	involved in the transport of maltose and maltodextrins
FR729_RS18320	COG2356	endonuclease I
FR729_RS18340	COG1982	Orn Lys Arg decarboxylase major
FR729_RS18345	COG0531	amino acid
FR729_RS18355	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
FR729_RS18360	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
FR729_RS18365	COG1162	GTPase activity
FR729_RS18370	COG1263	PTS System
FR729_RS18370	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FR729_RS18375	COG1999	signal sequence binding
FR729_RS18390	COG2909	trisaccharide binding
FR729_RS18395	COG0058	SHG alpha-glucan phosphorylase activity
FR729_RS18400	COG1640	4-alpha-glucanotransferase
FR729_RS18405	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FR729_RS18410	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FR729_RS18415	COG0366	Alpha amylase catalytic
FR729_RS18430	COG3366	ferrous iron transmembrane transporter activity
FR729_RS18435	COG0700	Nucleoside recognition
FR729_RS18440	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FR729_RS18445	COG3339	Conserved Protein
FR729_RS18460	COG1301	dicarboxylic acid transport
FR729_RS18470	COG0583	DNA-binding transcription factor activity
FR729_RS18490	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FR729_RS18495	COG1596	polysaccharide export
FR729_RS18510	COG2095	MarC family integral membrane protein
FR729_RS18515	COG4667	esterase of the alpha-beta hydrolase superfamily
FR729_RS18520	COG3397	chitin binding
FR729_RS18525	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
FR729_RS18530	COG0415	Belongs to the DNA photolyase family
FR729_RS18550	COG1686	Belongs to the peptidase S11 family
FR729_RS18575	COG0583	DNA-binding transcription factor activity
FR729_RS18580	COG4628	conserved protein (DUF2132)
FR729_RS18600	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
FR729_RS18605	COG0628	permease
FR729_RS18645	COG2814	Major facilitator Superfamily
FR729_RS18655	COG0454	-acetyltransferase
FR729_RS18665	COG0745	RESPONSE REGULATOR receiver
FR729_RS18670	COG2205	protein histidine kinase activity
FR729_RS18685	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FR729_RS18690	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FR729_RS18695	COG1882	Formate acetyltransferase
FR729_RS18730	COG1360	Flagellar Motor Protein
FR729_RS18735	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
FR729_RS18740	COG1191	sigma factor activity
FR729_RS18745	COG1580	Controls the rotational direction of flagella during chemotaxis
FR729_RS18760	COG1516	flagellar protein fliS
FR729_RS18765	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
FR729_RS18770	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FR729_RS18785	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FR729_RS18795	COG1987	bacterial-type flagellum assembly
FR729_RS18835	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FR729_RS18895	COG0346	lactoylglutathione lyase activity
FR729_RS18920	COG0745	RESPONSE REGULATOR receiver
FR729_RS18945	COG5001	Diguanylate cyclase
FR729_RS18945	COG3300	MHYT domain
FR729_RS18950	COG0156	8-amino-7-oxononanoate synthase activity
FR729_RS18955	COG1063	alcohol dehydrogenase
FR729_RS18990	COG0668	transmembrane transport
FR729_RS19000	COG1304	FMN binding
FR729_RS19005	COG1620	l-lactate permease
FR729_RS19010	COG0583	DNA-binding transcription factor activity
FR729_RS19015	COG1505	serine-type exopeptidase activity
FR729_RS19020	COG4172	Belongs to the ABC transporter superfamily
FR729_RS19030	COG1067	ATP-dependent peptidase activity
FR729_RS19040	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
FR729_RS19060	COG1247	-acetyltransferase
FR729_RS19065	COG0437	4 iron, 4 sulfur cluster binding
FR729_RS19070	COG0348	domain, Protein
FR729_RS19090	COG1122	ATPase activity
FR729_RS19095	COG4720	Psort location CytoplasmicMembrane, score
FR729_RS19100	COG1566	PFAM secretion protein HlyD family protein
FR729_RS19110	COG3706	GGDEF domain
FR729_RS19125	COG0813	purine-nucleoside phosphorylase activity
FR729_RS19130	COG3272	Protein of unknown function (DUF1722)
FR729_RS19135	COG0789	Transcriptional regulator
FR729_RS19140	COG0415	Belongs to the DNA photolyase family
FR729_RS19145	COG1376	ErfK ybiS ycfS ynhG family protein
FR729_RS19145	COG1388	LysM domain
FR729_RS19155	COG0513	Belongs to the DEAD box helicase family
FR729_RS19160	COG1770	oligopeptidase
FR729_RS19165	COG4771	TonB-dependent receptor
FR729_RS19195	COG0573	inorganic phosphate transmembrane transporter activity
FR729_RS19200	COG0581	inorganic phosphate transmembrane transporter activity
FR729_RS19205	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FR729_RS19220	COG2304	oxidoreductase activity
FR729_RS19240	COG0714	Associated with various cellular activities
FR729_RS19255	COG2197	response regulator
FR729_RS19290	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
FR729_RS19295	COG1120	ATPase activity
FR729_RS19300	COG4774	siderophore transport
FR729_RS19305	COG1132	(ABC) transporter
FR729_RS19310	COG2205	protein histidine kinase activity
FR729_RS19320	COG0569	domain protein
FR729_RS19325	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FR729_RS19330	COG0583	DNA-binding transcription factor activity
FR729_RS19350	COG1012	belongs to the aldehyde dehydrogenase family
FR729_RS19355	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FR729_RS19360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FR729_RS19370	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
FR729_RS19375	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FR729_RS19405	COG2084	Dehydrogenase
FR729_RS19410	COG0753	catalase activity
FR729_RS19420	COG2130	NADP-dependent
FR729_RS19425	COG1309	transcriptional regulator
FR729_RS19470	COG3206	protein involved in exopolysaccharide biosynthesis
FR729_RS19470	COG0489	protein tyrosine kinase activity
FR729_RS19485	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FR729_RS19490	COG3842	ATPase activity
FR729_RS19500	COG1175	transmembrane transport
FR729_RS19505	COG3833	ABC-type maltose transport systems, permease component
FR729_RS19535	COG2354	Protein conserved in bacteria
FR729_RS19540	COG0418	dihydroorotase activity
FR729_RS19545	COG0401	homolog of Blt101
FR729_RS19550	COG0633	Ferredoxin
FR729_RS19550	COG3217	Mosc domain protein beta barrel domain protein
FR729_RS19550	COG3217	Mosc domain protein beta barrel domain protein
FR729_RS19550	COG0633	Ferredoxin
FR729_RS19560	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FR729_RS19600	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
FR729_RS19605	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FR729_RS19615	COG0848	biopolymer transport protein
FR729_RS19620	COG0811	peptide transport
FR729_RS19625	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
FR729_RS19635	COG3721	Heme iron utilization protein
FR729_RS19640	COG0748	coenzyme F420 binding
FR729_RS19655	COG0835	chemotaxis
FR729_RS19655	COG0784	Response regulator, receiver
FR729_RS19660	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FR729_RS19665	COG0534	Mate efflux family protein
FR729_RS19670	COG0444	Belongs to the ABC transporter superfamily
FR729_RS19675	COG4608	Belongs to the ABC transporter superfamily
FR729_RS19680	COG0747	negative chemotaxis
FR729_RS19690	COG1349	DNA-binding transcription factor activity
FR729_RS19695	COG2084	Dehydrogenase
FR729_RS19700	COG3395	kinase activity
FR729_RS19705	COG0235	Class ii aldolase
FR729_RS19710	COG3622	Belongs to the hyi family
FR729_RS19715	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FR729_RS19720	COG2610	gluconate transmembrane transporter activity
FR729_RS19740	COG0583	DNA-binding transcription factor activity
FR729_RS19745	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FR729_RS19755	COG4934	collagen metabolic process
FR729_RS19765	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FR729_RS19770	COG0789	Transcriptional regulator
FR729_RS19775	COG0366	Alpha amylase catalytic
FR729_RS19795	COG2249	NAD(P)H dehydrogenase (quinone) activity
FR729_RS19800	COG0589	response to stress
FR729_RS19805	COG0488	(ABC) transporter
FR729_RS19810	COG1505	serine-type exopeptidase activity
FR729_RS19820	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FR729_RS19830	COG2067	long-chain fatty acid transport protein
FR729_RS19840	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FR729_RS19865	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FR729_RS19885	COG3383	formate dehydrogenase (NAD+) activity
FR729_RS19895	COG0842	Transport permease protein
FR729_RS19900	COG1131	(ABC) transporter
FR729_RS19915	COG1881	PFAM PEBP family protein
FR729_RS19925	COG0798	PFAM Bile acid sodium symporter
FR729_RS19940	COG1733	regulation of RNA biosynthetic process
FR729_RS19965	COG4989	oxidoreductase activity
FR729_RS19990	COG0814	amino acid
FR729_RS20025	COG0739	heme binding
FR729_RS20030	COG5001	Diguanylate cyclase
FR729_RS20035	COG0583	DNA-binding transcription factor activity
FR729_RS20040	COG2814	Major facilitator Superfamily
FR729_RS20055	COG0697	spore germination
FR729_RS20060	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
FR729_RS20070	COG0179	Fumarylacetoacetate (FAA) hydrolase
FR729_RS20090	COG1280	lysine exporter protein (LysE YggA)
FR729_RS20105	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FR729_RS20110	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FR729_RS20115	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
FR729_RS20120	COG1845	cytochrome c oxidase, subunit III
FR729_RS20140	COG1612	heme a metabolic process
FR729_RS20145	COG0109	protoheme IX farnesyltransferase activity
FR729_RS20150	COG0545	Peptidyl-prolyl cis-trans isomerase
FR729_RS20180	COG1278	Cold shock
FR729_RS20185	COG3036	rescue of stalled ribosome
FR729_RS20190	COG2199	diguanylate cyclase activity
FR729_RS20205	COG1132	(ABC) transporter
FR729_RS20215	COG1538	Outer membrane efflux protein
FR729_RS20220	COG2205	protein histidine kinase activity
FR729_RS20220	COG0784	Response regulator, receiver
FR729_RS20245	COG0840	transmembrane signaling receptor activity
FR729_RS20250	COG0783	Belongs to the Dps family
FR729_RS20260	COG2133	pyrroloquinoline quinone binding
FR729_RS20265	COG1454	alcohol dehydrogenase
FR729_RS20270	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
FR729_RS20295	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FR729_RS20300	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FR729_RS20305	COG3186	Phenylalanine-4-hydroxylase
FR729_RS20330	COG3530	Putative quorum-sensing-regulated virulence factor
FR729_RS20345	COG2186	Transcriptional regulator
FR729_RS20360	COG1279	arginine transmembrane transporter activity
FR729_RS20370	COG0730	response to heat
FR729_RS20380	COG0513	Belongs to the DEAD box helicase family
FR729_RS20385	COG4628	conserved protein (DUF2132)
FR729_RS20395	COG0133	tryptophan synthase activity
FR729_RS20400	COG1278	Cold shock
FR729_RS20410	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
FR729_RS20420	COG0523	cobalamin synthesis protein
FR729_RS20425	COG0513	Belongs to the DEAD box helicase family
FR729_RS20445	COG2200	EAL domain
FR729_RS20450	COG1119	ATPase activity
FR729_RS20490	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
FR729_RS20495	COG0513	Belongs to the DEAD box helicase family
FR729_RS20505	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FR729_RS20515	COG1073	alpha beta
FR729_RS20520	COG1073	alpha beta
FR729_RS20535	COG0436	Aminotransferase
FR729_RS20605	COG0247	lactate metabolic process
FR729_RS20605	COG0277	FAD linked oxidase domain protein
FR729_RS20620	COG1024	Enoyl-CoA hydratase
FR729_RS20625	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FR729_RS20630	COG1960	acyl-CoA dehydrogenase activity
FR729_RS20640	COG0183	Belongs to the thiolase family
FR729_RS20655	COG1024	Enoyl-CoA hydratase
FR729_RS20660	COG1024	Enoyl-CoA hydratase
FR729_RS20670	COG1028	Short-chain dehydrogenase reductase Sdr
FR729_RS20675	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FR729_RS20680	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FR729_RS20685	COG1845	cytochrome c oxidase, subunit III
FR729_RS20690	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
FR729_RS20695	COG0109	protoheme IX farnesyltransferase activity
FR729_RS20700	COG1902	pentaerythritol trinitrate reductase activity
FR729_RS20700	COG0446	pyridine nucleotide-disulphide oxidoreductase
FR729_RS20715	COG1012	belongs to the aldehyde dehydrogenase family
FR729_RS20725	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FR729_RS20755	COG1126	abc transporter atp-binding protein
FR729_RS20760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FR729_RS20765	COG4215	(ABC) transporter
FR729_RS20770	COG4160	amino acid transport
FR729_RS20840	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FR729_RS20845	COG2176	DNA-directed DNA polymerase activity
FR729_RS20850	COG0517	IMP dehydrogenase activity
FR729_RS20855	COG2186	Transcriptional regulator
FR729_RS20860	COG2186	Transcriptional regulator
FR729_RS20905	COG1917	Cupin 2, conserved barrel domain protein
FR729_RS20910	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FR729_RS20915	COG0800	Aldolase
FR729_RS20925	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
FR729_RS20930	COG1028	Short-chain dehydrogenase reductase Sdr
FR729_RS20935	COG2847	Copper chaperone PCu(A)C
FR729_RS20990	COG3706	GGDEF domain
FR729_RS20995	COG0814	amino acid
FR729_RS21005	COG0243	molybdopterin cofactor binding
FR729_RS21030	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FR729_RS21030	COG1116	anion transmembrane transporter activity
FR729_RS21035	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FR729_RS21040	COG1116	anion transmembrane transporter activity
FR729_RS21045	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FR729_RS21045	COG2146	nitrite reductase [NAD(P)H] activity
FR729_RS21095	COG0515	serine threonine protein kinase
FR729_RS21095	COG2815	serine threonine protein kinase
FR729_RS21130	COG0631	protein serine/threonine phosphatase activity
FR729_RS21185	COG3501	Rhs element vgr protein
FR729_RS21200	COG0420	3'-5' exonuclease activity
FR729_RS21205	COG0419	ATPase involved in DNA repair
FR729_RS21215	COG3040	lipid binding
FR729_RS21225	COG1288	antiporter activity
FR729_RS21235	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
FR729_RS21250	COG2425	protein containing a von Willebrand factor type A (vWA) domain
FR729_RS21265	COG0583	DNA-binding transcription factor activity
FR729_RS21270	COG0277	FAD linked oxidase domain protein
FR729_RS21285	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FR729_RS21355	COG5001	Diguanylate cyclase
FR729_RS21360	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FR729_RS21365	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FR729_RS21375	COG2116	formate transmembrane transporter activity
FR729_RS21395	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
FR729_RS21430	COG3118	belongs to the thioredoxin family
FR729_RS21435	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FR729_RS21460	COG2271	Major facilitator Superfamily
FR729_RS21465	COG3851	Histidine kinase
FR729_RS21470	COG2197	response regulator
FR729_RS21480	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FR729_RS21485	COG0583	DNA-binding transcription factor activity
FR729_RS21505	COG0384	phenazine biosynthesis protein PhzF
FR729_RS21510	COG1794	racemase activity, acting on amino acids and derivatives
FR729_RS21540	COG1328	CTP reductase activity
FR729_RS21545	COG0602	queuosine metabolic process
FR729_RS21550	COG0534	Mate efflux family protein
FR729_RS21555	COG2207	Transcriptional regulator
FR729_RS21565	COG4067	protein conserved in archaea
FR729_RS21565	COG0189	ligase activity
FR729_RS21575	COG3111	PFAM Bacterial OB fold (BOF) protein
FR729_RS21585	COG0725	ABC transporter, periplasmic molybdate-binding protein
FR729_RS21590	COG4149	molybdate abc transporter
FR729_RS21595	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
FR729_RS21605	COG2203	Gaf domain
FR729_RS21605	COG5001	Diguanylate cyclase
FR729_RS21605	COG4251	negative regulation of phosphorylation
FR729_RS21605	COG3706	GGDEF domain
FR729_RS21625	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
FR729_RS21630	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
FR729_RS21655	COG3140	Belongs to the UPF0181 family
FR729_RS21670	COG0583	DNA-binding transcription factor activity
FR729_RS21745	COG0023	Translation Initiation Factor
FR729_RS21755	COG1181	Belongs to the D-alanine--D-alanine ligase family
FR729_RS21765	COG0045	succinate-CoA ligase (ADP-forming) activity
FR729_RS21765	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FR729_RS21765	COG1042	CoA-binding domain protein
FR729_RS21770	COG0583	DNA-binding transcription factor activity
FR729_RS21785	COG3447	MASE1 domain protein
FR729_RS21785	COG5002	protein histidine kinase activity
FR729_RS21785	COG5001	Diguanylate cyclase
FR729_RS21790	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
FR729_RS21795	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FR729_RS21800	COG1984	allophanate hydrolase subunit 2
FR729_RS21810	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
FR729_RS21815	COG4181	ATPase activity
FR729_RS21825	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FR729_RS21830	COG3300	MHYT domain
FR729_RS21830	COG5001	Diguanylate cyclase
FR729_RS21840	COG0484	heat shock protein binding
FR729_RS21865	COG4533	DNA binding
FR729_RS21875	COG2050	protein possibly involved in aromatic compounds catabolism
FR729_RS21890	COG2067	long-chain fatty acid transport protein
FR729_RS21895	COG2267	carboxylic ester hydrolase activity
FR729_RS21920	COG0737	Belongs to the 5'-nucleotidase family
FR729_RS21925	COG3593	DNA synthesis involved in DNA repair
FR729_RS21935	COG0583	DNA-binding transcription factor activity
FR729_RS21940	COG2116	formate transmembrane transporter activity
FR729_RS21945	COG2353	YceI-like domain
FR729_RS21950	COG3038	cytochrome b561
FR729_RS21970	COG0513	Belongs to the DEAD box helicase family
FR729_RS21975	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
FR729_RS21985	COG0840	transmembrane signaling receptor activity
FR729_RS21990	COG0546	phosphoglycolate phosphatase activity
FR729_RS22005	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FR729_RS22010	COG2759	Belongs to the formate--tetrahydrofolate ligase family
FR729_RS22015	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FR729_RS22025	COG2207	Transcriptional regulator
FR729_RS22030	COG1979	alcohol dehydrogenase
FR729_RS22040	COG1126	abc transporter atp-binding protein
FR729_RS22045	COG0765	amino acid transport
FR729_RS22050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FR729_RS22055	COG0765	amino acid transport
FR729_RS22060	COG2199	diguanylate cyclase activity
FR729_RS22060	COG2203	Gaf domain
FR729_RS22060	COG2200	EAL domain
FR729_RS22075	COG1609	Transcriptional regulator
FR729_RS22080	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FR729_RS22080	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FR729_RS22085	COG1105	Belongs to the carbohydrate kinase PfkB family
FR729_RS22090	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FR729_RS22090	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FR729_RS22090	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
FR729_RS22120	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FR729_RS22130	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FR729_RS22135	COG0509	glycine decarboxylation via glycine cleavage system
FR729_RS22145	COG0346	lactoylglutathione lyase activity
FR729_RS22150	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FR729_RS22155	COG0583	DNA-binding transcription factor activity
FR729_RS22160	COG0697	spore germination
FR729_RS22165	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FR729_RS22190	COG2176	DNA-directed DNA polymerase activity
FR729_RS22235	COG0242	peptide deformylase activity
FR729_RS22270	COG2239	Acts as a magnesium transporter
FR729_RS22290	COG0346	lactoylglutathione lyase activity
FR729_RS22295	COG1902	pentaerythritol trinitrate reductase activity
FR729_RS22315	COG5642	Protein of unknown function (DUF2384)
FR729_RS22320	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
FR729_RS22355	COG2076	Multidrug Resistance protein
FR729_RS22375	COG2962	Rard protein
FR729_RS22390	COG0835	chemotaxis
FR729_RS22390	COG0784	Response regulator, receiver
FR729_RS22395	COG2197	response regulator
FR729_RS22405	COG3706	GGDEF domain
FR729_RS22410	COG2197	response regulator
FR729_RS22415	COG5001	Diguanylate cyclase
FR729_RS22415	COG3300	MHYT domain
FR729_RS22420	COG2205	protein histidine kinase activity
FR729_RS22420	COG0784	Response regulator, receiver
FR729_RS22425	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
FR729_RS22445	COG1214	PFAM Peptidase M22, glycoprotease
FR729_RS22445	COG0456	acetyltransferase
FR729_RS22455	COG3069	C4-dicarboxylate transmembrane transporter activity
FR729_RS22480	COG3111	PFAM Bacterial OB fold (BOF) protein
FR729_RS22485	COG1597	lipid kinase activity
FR729_RS22490	COG0583	DNA-binding transcription factor activity
FR729_RS22495	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FR729_RS22525	COG0714	Associated with various cellular activities
FR729_RS22530	COG0641	radical SAM
FR729_RS22535	COG3119	arylsulfatase activity
FR729_RS22545	COG3119	arylsulfatase activity
FR729_RS22550	COG0745	RESPONSE REGULATOR receiver
FR729_RS22565	COG2205	protein histidine kinase activity
FR729_RS22565	COG2198	Histidine kinase
FR729_RS22565	COG0784	Response regulator, receiver
FR729_RS22570	COG1879	ABC-type sugar transport system periplasmic component
FR729_RS22575	COG1803	Methylglyoxal synthase
FR729_RS22580	COG0210	DNA helicase
FR729_RS22585	COG1289	transmembrane transporter activity
FR729_RS22615	COG1629	transport
FR729_RS22615	COG4771	TonB-dependent receptor
FR729_RS22625	COG0789	Transcriptional regulator
FR729_RS22630	COG4604	ABC transporter, ATP-binding protein
FR729_RS22635	COG4605	iron ion homeostasis
FR729_RS22640	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FR729_RS22645	COG4607	ABC-type enterochelin transport system periplasmic component
FR729_RS22655	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
FR729_RS22665	COG1609	Transcriptional regulator
FR729_RS22670	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FR729_RS22675	COG1879	ABC-type sugar transport system periplasmic component
FR729_RS22680	COG1172	Belongs to the binding-protein-dependent transport system permease family
FR729_RS22685	COG1129	ABC transporter
FR729_RS22690	COG1869	D-ribose catabolic process
FR729_RS22695	COG5001	Diguanylate cyclase
FR729_RS22750	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FR729_RS22760	COG2205	protein histidine kinase activity
FR729_RS22760	COG0784	Response regulator, receiver
FR729_RS22775	COG0330	HflC and HflK could
FR729_RS22790	COG0517	IMP dehydrogenase activity
FR729_RS22790	COG4175	Glycine betaine
FR729_RS22795	COG4176	ABC-type proline glycine betaine transport system permease component
FR729_RS22810	COG1012	belongs to the aldehyde dehydrogenase family
FR729_RS22815	COG1309	transcriptional regulator
FR729_RS22825	COG1028	Short-chain dehydrogenase reductase Sdr
FR729_RS22840	COG1024	Enoyl-CoA hydratase
FR729_RS22845	COG1960	acyl-CoA dehydrogenase activity
FR729_RS22855	COG0183	Belongs to the thiolase family
FR729_RS22865	COG1960	acyl-CoA dehydrogenase activity
FR729_RS22870	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FR729_RS22880	COG4770	biotin carboxylase activity
FR729_RS22895	COG3264	Mechanosensitive ion channel
FR729_RS22895	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
FR729_RS22900	COG0110	maltose O-acetyltransferase activity
FR729_RS22905	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FR729_RS22910	COG1271	oxidase subunit
FR729_RS22915	COG1294	oxidase, subunit
FR729_RS22930	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FR729_RS22940	COG3527	Alpha-acetolactate decarboxylase
FR729_RS22955	COG0500	methyltransferase
FR729_RS22985	COG1022	Amp-dependent synthetase and ligase
FR729_RS23010	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FR729_RS23015	COG1263	PTS System
FR729_RS23015	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FR729_RS23020	COG1486	melibiose metabolic process
FR729_RS23025	COG2188	Transcriptional regulator
FR729_RS23030	COG1320	monovalent cation:proton antiporter activity
FR729_RS23035	COG2212	antiporter activity
FR729_RS23050	COG1006	Multisubunit Na H antiporter MnhC subunit
FR729_RS23055	COG2111	Na H antiporter
FR729_RS23055	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FR729_RS23065	COG0589	response to stress
FR729_RS23070	COG4221	oxidoreductase activity
FR729_RS23075	COG0583	DNA-binding transcription factor activity
FR729_RS23085	COG2814	Major facilitator Superfamily
FR729_RS23150	COG1522	sequence-specific DNA binding
FR729_RS23185	COG0515	serine threonine protein kinase
FR729_RS23210	COG3501	Rhs element vgr protein
FR729_RS23250	COG0739	heme binding
FR729_RS23265	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FR729_RS23280	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FR729_RS23280	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FR729_RS23310	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
FR729_RS23320	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FR729_RS23320	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FR729_RS23335	COG4989	oxidoreductase activity
FR729_RS23350	COG0038	chloride channel
FR729_RS23370	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FR729_RS23390	COG2897	thiosulfate sulfurtransferase activity
FR729_RS23400	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FR729_RS23405	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FR729_RS23410	COG0840	transmembrane signaling receptor activity
FR729_RS23415	COG2814	Major facilitator Superfamily
FR729_RS23420	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FR729_RS23430	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FR729_RS23440	COG0840	transmembrane signaling receptor activity
FR729_RS23460	COG2195	Cleaves the N-terminal amino acid of tripeptides
FR729_RS23475	COG2197	response regulator
FR729_RS23480	COG3850	Histidine kinase
FR729_RS23485	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FR729_RS23495	COG0243	molybdopterin cofactor binding
FR729_RS23505	COG3005	denitrification pathway
FR729_RS23515	COG3243	poly(R)-hydroxyalkanoic acid synthase
FR729_RS23525	COG0183	Belongs to the thiolase family
FR729_RS23535	COG1280	lysine exporter protein (LysE YggA)
FR729_RS23545	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FR729_RS23550	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FR729_RS23600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FR729_RS23605	COG1846	Transcriptional regulator
FR729_RS23610	COG0784	Response regulator, receiver
FR729_RS23610	COG2205	protein histidine kinase activity
FR729_RS23615	COG1879	ABC-type sugar transport system periplasmic component
FR729_RS23620	COG2827	Endonuclease containing a URI domain
FR729_RS23625	COG3132	Protein of unknown function, DUF480
FR729_RS23645	COG0784	Response regulator, receiver
FR729_RS23645	COG5002	protein histidine kinase activity
FR729_RS23645	COG2205	protein histidine kinase activity
FR729_RS23670	COG0583	DNA-binding transcription factor activity
FR729_RS23680	COG0531	amino acid
FR729_RS23695	COG2205	protein histidine kinase activity
FR729_RS23700	COG0745	RESPONSE REGULATOR receiver
FR729_RS23725	COG1566	PFAM secretion protein HlyD family protein
FR729_RS23730	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FR729_RS23735	COG2239	Acts as a magnesium transporter
FR729_RS23740	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
FR729_RS23745	COG0402	S-adenosylhomocysteine deaminase activity
FR729_RS23750	COG1418	mRNA catabolic process
FR729_RS23760	COG2814	Major facilitator Superfamily
FR729_RS23770	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FR729_RS23790	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FR729_RS23805	COG0745	RESPONSE REGULATOR receiver
FR729_RS23810	COG2205	protein histidine kinase activity
FR729_RS23820	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FR729_RS23825	COG2194	sulfuric ester hydrolase activity
FR729_RS23845	COG4667	esterase of the alpha-beta hydrolase superfamily
FR729_RS23850	COG1741	Belongs to the pirin family
FR729_RS23855	COG1278	Cold shock
FR729_RS23870	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FR729_RS23875	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FR729_RS23875	COG0678	peroxiredoxin activity
FR729_RS23885	COG1686	Belongs to the peptidase S11 family
FR729_RS23890	COG0625	glutathione transferase activity
FR729_RS23900	COG1621	beta-fructofuranosidase activity
FR729_RS23905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FR729_RS23930	COG1028	Short-chain dehydrogenase reductase Sdr
FR729_RS23945	COG3746	phosphate-selective porin O and P
FR729_RS23965	COG0583	DNA-binding transcription factor activity
FR729_RS23970	COG2207	Transcriptional regulator
FR729_RS23970	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FR729_RS23975	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FR729_RS23995	COG0513	Belongs to the DEAD box helicase family
FR729_RS24005	COG0583	DNA-binding transcription factor activity