locus-tag	class	description
AL539_RS00020	COG0681	Belongs to the peptidase S26 family
AL539_RS00045	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AL539_RS00130	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AL539_RS00210	COG1620	l-lactate permease
AL539_RS00215	COG0247	lactate metabolic process
AL539_RS00220	COG1139	Iron-sulfur cluster binding protein
AL539_RS00225	COG1556	Lactate utilization protein
AL539_RS00230	COG0583	DNA-binding transcription factor activity
AL539_RS00300	COG1192	Involved in chromosome partitioning
AL539_RS00310	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AL539_RS00425	COG3209	COG3209 Rhs family protein
AL539_RS00600	COG3423	Transcriptional regulator
AL539_RS00670	COG2433	Pfam Transposase IS66
AL539_RS00720	COG5564	TIM-barrel signal transduction protein
AL539_RS00725	COG5441	Belongs to the UPF0261 family
AL539_RS00735	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AL539_RS00755	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AL539_RS00760	COG0732	type I restriction modification DNA specificity domain
AL539_RS00770	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AL539_RS00780	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AL539_RS00805	COG0629	single-stranded DNA binding
AL539_RS00820	COG0714	Associated with various cellular activities
AL539_RS00845	COG2003	Belongs to the UPF0758 family
AL539_RS00875	COG2862	Uncharacterized protein family, UPF0114
AL539_RS01020	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
AL539_RS01115	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AL539_RS01175	COG0714	Associated with various cellular activities
AL539_RS01205	COG5433	transposase activity
AL539_RS01240	COG1294	oxidase, subunit
AL539_RS01245	COG1271	oxidase subunit
AL539_RS01265	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL539_RS01270	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL539_RS01295	COG3568	Endonuclease Exonuclease Phosphatase
AL539_RS01455	COG0583	DNA-binding transcription factor activity
AL539_RS01465	COG0686	Belongs to the AlaDH PNT family
AL539_RS01475	COG1674	ftsk spoiiie
AL539_RS01485	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AL539_RS01505	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AL539_RS01530	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AL539_RS01550	COG0300	oxidoreductase activity
AL539_RS01565	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AL539_RS01575	COG2268	Band 7 protein
AL539_RS01585	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AL539_RS01590	COG2915	High frequency lysogenization protein hflD homolog
AL539_RS01605	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL539_RS01615	COG1757	Na H antiporter
AL539_RS01625	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AL539_RS01635	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AL539_RS01635	COG0131	Imidazoleglycerol-phosphate dehydratase
AL539_RS01640	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AL539_RS01645	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AL539_RS01655	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AL539_RS01655	COG0140	phosphoribosyl-ATP diphosphatase activity
AL539_RS01660	COG3012	SEC-C Motif Domain Protein
AL539_RS01665	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AL539_RS01670	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AL539_RS01675	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AL539_RS01680	COG0215	cysteine-tRNA ligase activity
AL539_RS01685	COG1435	thymidine kinase activity
AL539_RS01715	COG2116	formate transmembrane transporter activity
AL539_RS01725	COG0390	transport system, permease component
AL539_RS01730	COG4459	periplasmic nitrate reductase
AL539_RS01735	COG3005	denitrification pathway
AL539_RS01740	COG0243	molybdopterin cofactor binding
AL539_RS01755	COG1227	inorganic diphosphatase activity
AL539_RS01765	COG4172	Belongs to the ABC transporter superfamily
AL539_RS01775	COG4171	peptide transport system, permease
AL539_RS01790	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AL539_RS01795	COG1842	Phage shock protein A
AL539_RS01805	COG1983	PspC domain protein
AL539_RS01825	COG2818	Glycosylase
AL539_RS01830	COG5380	lipid catabolic process
AL539_RS01835	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
AL539_RS01840	COG0626	cystathionine gamma-synthase activity
AL539_RS01850	COG0733	neurotransmitter:sodium symporter activity
AL539_RS01855	COG0564	pseudouridine synthase activity
AL539_RS01865	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AL539_RS01870	COG1151	hydroxylamine reductase activity
AL539_RS01875	COG3604	Transcriptional regulator
AL539_RS01890	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AL539_RS01895	COG4136	ATPase activity
AL539_RS01900	COG4135	transport system, permease component
AL539_RS01905	COG4134	Bacterial extracellular solute-binding protein
AL539_RS01915	COG3313	Fe-S protein
AL539_RS01940	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AL539_RS01960	COG1061	Type III restriction enzyme res subunit
AL539_RS01965	COG1187	pseudouridine synthase activity
AL539_RS01975	COG2814	Major facilitator Superfamily
AL539_RS01985	COG0702	epimerase
AL539_RS01990	COG0534	Mate efflux family protein
AL539_RS02010	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AL539_RS02020	COG1960	acyl-CoA dehydrogenase activity
AL539_RS02025	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AL539_RS02030	COG2985	domain, Protein
AL539_RS02030	COG3273	potassium ion transport
AL539_RS02035	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AL539_RS02045	COG1737	Transcriptional regulator
AL539_RS02050	COG0076	glutamate decarboxylase activity
AL539_RS02060	COG2431	L-lysine efflux transmembrane transporter activity
AL539_RS02080	COG3070	regulator of competence-specific genes
AL539_RS02095	COG4191	Histidine kinase
AL539_RS02095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL539_RS02105	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AL539_RS02115	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AL539_RS02120	COG4988	ABC transporter
AL539_RS02125	COG0492	ferredoxin-NADP+ reductase activity
AL539_RS02150	COG0471	metal ion transport
AL539_RS02155	COG2949	membrane
AL539_RS02160	COG0281	malic enzyme
AL539_RS02165	COG1643	Atp-dependent helicase
AL539_RS02180	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AL539_RS02215	COG0277	FAD linked oxidase domain protein
AL539_RS02215	COG0247	lactate metabolic process
AL539_RS02230	COG2986	histidine ammonia-lyase
AL539_RS02235	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AL539_RS02240	COG0010	Belongs to the arginase family
AL539_RS02245	COG1228	amidohydrolase
AL539_RS02250	COG2188	Transcriptional regulator
AL539_RS02265	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AL539_RS02275	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AL539_RS02285	COG0393	Putative heavy-metal-binding
AL539_RS02320	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AL539_RS02325	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL539_RS02325	COG0072	phenylalanine-tRNA ligase activity
AL539_RS02335	COG0776	regulation of translation
AL539_RS02345	COG0500	methyltransferase
AL539_RS02350	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AL539_RS02355	COG0295	cytidine deaminase activity
AL539_RS02360	COG1346	cytolysis
AL539_RS02365	COG1380	Effector of murein hydrolase LrgA
AL539_RS02370	COG2925	Exonuclease
AL539_RS02375	COG1823	symporter activity
AL539_RS02380	COG0702	epimerase
AL539_RS02385	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AL539_RS02390	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AL539_RS02410	COG2988	succinylglutamate desuccinylase activity
AL539_RS02415	COG4139	cobalamin transport
AL539_RS02420	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
AL539_RS02440	COG0583	DNA-binding transcription factor activity
AL539_RS02450	COG1451	nucleotide metabolic process
AL539_RS02485	COG3938	Belongs to the proline racemase family
AL539_RS02500	COG2423	ornithine cyclodeaminase activity
AL539_RS02505	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AL539_RS02510	COG3842	ATPase activity
AL539_RS02515	COG1176	ABC-type spermidine putrescine transport system, permease component I
AL539_RS02520	COG1177	transmembrane transport
AL539_RS02530	COG3291	Pkd domain containing protein
AL539_RS02550	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL539_RS02555	COG0601	transmembrane transport
AL539_RS02565	COG2195	Cleaves the N-terminal amino acid of tripeptides
AL539_RS02575	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
AL539_RS02585	COG0625	glutathione transferase activity
AL539_RS02755	COG1757	Na H antiporter
AL539_RS02760	COG0174	glutamine synthetase
AL539_RS02770	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AL539_RS02775	COG1396	sequence-specific DNA binding
AL539_RS02775	COG1917	Cupin 2, conserved barrel domain protein
AL539_RS02780	COG1012	belongs to the aldehyde dehydrogenase family
AL539_RS02785	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AL539_RS02795	COG2957	Belongs to the agmatine deiminase family
AL539_RS02800	COG1012	belongs to the aldehyde dehydrogenase family
AL539_RS02805	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AL539_RS02810	COG2200	EAL domain
AL539_RS02820	COG1846	Transcriptional regulator
AL539_RS02825	COG2315	Protein conserved in bacteria
AL539_RS02865	COG3063	Type IV pilus biogenesis stability protein PilW
AL539_RS02870	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
AL539_RS02885	COG1560	Kdo2-lipid A biosynthetic process
AL539_RS02890	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AL539_RS02895	COG1280	lysine exporter protein (LysE YggA)
AL539_RS02905	COG1115	amino acid carrier protein
AL539_RS02930	COG1368	sulfuric ester hydrolase activity
AL539_RS02935	COG2113	Glycine betaine
AL539_RS02940	COG4176	ABC-type proline glycine betaine transport system permease component
AL539_RS02945	COG4175	Glycine betaine
AL539_RS02960	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL539_RS02965	COG0456	acetyltransferase
AL539_RS02970	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AL539_RS02975	COG0662	Cupin 2, conserved barrel domain protein
AL539_RS02980	COG0527	aspartate kinase activity
AL539_RS02985	COG3119	arylsulfatase activity
AL539_RS03000	COG0641	radical SAM
AL539_RS03015	COG3119	arylsulfatase activity
AL539_RS03040	COG1538	Outer membrane efflux protein
AL539_RS03055	COG1349	DNA-binding transcription factor activity
AL539_RS03060	COG0673	inositol 2-dehydrogenase activity
AL539_RS03065	COG4702	Belongs to the UPF0303 family
AL539_RS03090	COG0471	metal ion transport
AL539_RS03105	COG3300	MHYT domain
AL539_RS03105	COG5001	Diguanylate cyclase
AL539_RS03120	COG1328	CTP reductase activity
AL539_RS03125	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AL539_RS03135	COG0861	Integral membrane protein TerC family
AL539_RS03145	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AL539_RS03155	COG0814	amino acid
AL539_RS03170	COG1120	ATPase activity
AL539_RS03175	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AL539_RS03185	COG4774	siderophore transport
AL539_RS03195	COG1132	(ABC) transporter
AL539_RS03200	COG1132	(ABC) transporter
AL539_RS03215	COG0583	DNA-binding transcription factor activity
AL539_RS03240	COG0443	Heat shock 70 kDa protein
AL539_RS03245	COG0443	Heat shock 70 kDa protein
AL539_RS03290	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AL539_RS03295	COG1643	Atp-dependent helicase
AL539_RS03310	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL539_RS03320	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AL539_RS03325	COG1215	transferase activity, transferring glycosyl groups
AL539_RS03330	COG0438	transferase activity, transferring glycosyl groups
AL539_RS03360	COG0438	transferase activity, transferring glycosyl groups
AL539_RS03370	COG2204	response regulator
AL539_RS03400	COG1793	dna ligase
AL539_RS03410	COG0534	Mate efflux family protein
AL539_RS03415	COG0307	riboflavin synthase, alpha
AL539_RS03425	COG3001	Fructosamine kinase
AL539_RS03435	COG3706	GGDEF domain
AL539_RS03445	COG0791	NLP P60 protein
AL539_RS03480	COG3148	PFAM DTW domain containing protein
AL539_RS03485	COG1940	carbohydrate kinase activity
AL539_RS03495	COG0303	'Molybdopterin
AL539_RS03500	COG0746	molybdenum cofactor guanylyltransferase activity
AL539_RS03505	COG3842	ATPase activity
AL539_RS03520	COG2204	response regulator
AL539_RS03525	COG4191	Histidine kinase
AL539_RS03535	COG0488	(ABC) transporter
AL539_RS03540	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AL539_RS03560	COG3381	protein complex oligomerization
AL539_RS03570	COG3383	formate dehydrogenase (NAD+) activity
AL539_RS03570	COG0243	molybdopterin cofactor binding
AL539_RS03575	COG0437	4 iron, 4 sulfur cluster binding
AL539_RS03710	COG0004	ammonium transporteR
AL539_RS03715	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AL539_RS03720	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AL539_RS03730	COG1177	transmembrane transport
AL539_RS03740	COG3842	ATPase activity
AL539_RS03765	COG0589	response to stress
AL539_RS03770	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AL539_RS03785	COG2217	Heavy metal translocating P-type atpase
AL539_RS03795	COG2010	Cytochrome c
AL539_RS03810	COG3278	Belongs to the heme-copper respiratory oxidase family
AL539_RS03825	COG2205	protein histidine kinase activity
AL539_RS03825	COG0784	Response regulator, receiver
AL539_RS03855	COG3120	sequence-specific DNA binding
AL539_RS03860	COG1067	ATP-dependent peptidase activity
AL539_RS03865	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AL539_RS03880	COG0488	(ABC) transporter
AL539_RS03890	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AL539_RS03890	COG0116	Belongs to the methyltransferase superfamily
AL539_RS03900	COG0167	dihydroorotate dehydrogenase activity
AL539_RS03905	COG2902	Dehydrogenase
AL539_RS03915	COG0308	aminopeptidase N
AL539_RS03930	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
AL539_RS03935	COG1956	GAF domain-containing protein
AL539_RS03940	COG1132	(ABC) transporter
AL539_RS03945	COG2995	paraquat-inducible protein a
AL539_RS03950	COG3008	intermembrane lipid transfer
AL539_RS03975	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AL539_RS03980	COG1666	GTP binding
AL539_RS03995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL539_RS04000	COG4597	amino acid ABC transporter
AL539_RS04005	COG0765	amino acid transport
AL539_RS04010	COG1126	abc transporter atp-binding protein
AL539_RS04015	COG0670	Belongs to the BI1 family
AL539_RS04025	COG2920	part of a sulfur-relay system
AL539_RS04030	COG1254	Belongs to the acylphosphatase family
AL539_RS04055	COG2885	chlorophyll binding
AL539_RS04105	COG2199	diguanylate cyclase activity
AL539_RS04105	COG2203	Gaf domain
AL539_RS04110	COG1414	Transcriptional regulator
AL539_RS04120	COG0656	L-ascorbic acid biosynthetic process
AL539_RS04125	COG0583	DNA-binding transcription factor activity
AL539_RS04135	COG0583	DNA-binding transcription factor activity
AL539_RS04140	COG2814	Major facilitator Superfamily
AL539_RS04160	COG1335	isochorismatase
AL539_RS04165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL539_RS04180	COG1410	methionine synthase
AL539_RS04180	COG0646	methionine synthase
AL539_RS04185	COG1126	abc transporter atp-binding protein
AL539_RS04190	COG0765	amino acid transport
AL539_RS04195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL539_RS04210	COG0583	DNA-binding transcription factor activity
AL539_RS04225	COG0583	DNA-binding transcription factor activity
AL539_RS04235	COG0583	DNA-binding transcription factor activity
AL539_RS04250	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AL539_RS04255	COG0602	queuosine metabolic process
AL539_RS04260	COG0561	phosphatase activity
AL539_RS04285	COG2828	Protein conserved in bacteria
AL539_RS04295	COG0372	Belongs to the citrate synthase family
AL539_RS04300	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AL539_RS04335	COG0730	response to heat
AL539_RS04360	COG0457	Tetratricopeptide repeat
AL539_RS04430	COG4790	Type iii secretion
AL539_RS04435	COG4794	Type iii secretion
AL539_RS04440	COG4791	protein targeting
AL539_RS04445	COG4792	protein secretion
AL539_RS04450	COG2207	Transcriptional regulator
AL539_RS04480	COG3177	Filamentation induced by cAMP protein fic
AL539_RS04500	COG4669	(LipO)protein
AL539_RS04570	COG1012	belongs to the aldehyde dehydrogenase family
AL539_RS04575	COG3284	Transcriptional regulator
AL539_RS04590	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AL539_RS04595	COG0363	glucosamine-6-phosphate deaminase activity
AL539_RS04600	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AL539_RS04605	COG2207	Transcriptional regulator
AL539_RS04615	COG4565	transcriptional regulatory protein
AL539_RS04620	COG3290	protein histidine kinase activity
AL539_RS04635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL539_RS04665	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
AL539_RS04675	COG2985	domain, Protein
AL539_RS04705	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AL539_RS04720	COG1280	lysine exporter protein (LysE YggA)
AL539_RS04725	COG1280	lysine exporter protein (LysE YggA)
AL539_RS04730	COG5507	3-demethylubiquinone-9 3-methyltransferase
AL539_RS04750	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AL539_RS04755	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL539_RS04760	COG0110	maltose O-acetyltransferase activity
AL539_RS04870	COG2824	Alkylphosphonate utilization operon protein PhnA
AL539_RS04965	COG2801	Transposase and inactivated derivatives
AL539_RS05410	COG2026	Addiction module toxin, RelE StbE family
AL539_RS05445	COG2026	Addiction module toxin, RelE StbE family
AL539_RS05455	COG2026	Addiction module toxin, RelE StbE family
AL539_RS05555	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL539_RS05565	COG3768	UPF0283 membrane protein
AL539_RS05570	COG3106	COG3106 Predicted ATPase
AL539_RS05590	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AL539_RS05595	COG2205	protein histidine kinase activity
AL539_RS05595	COG0784	Response regulator, receiver
AL539_RS05605	COG0494	nUDIX hydrolase
AL539_RS05610	COG0814	amino acid
AL539_RS05615	COG1760	l-serine dehydratase
AL539_RS05620	COG2200	EAL domain
AL539_RS05630	COG0720	synthase
AL539_RS05635	COG0840	transmembrane signaling receptor activity
AL539_RS05640	COG0017	Asparaginyl-tRNA synthetase
AL539_RS05650	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL539_RS05665	COG1448	Aminotransferase
AL539_RS05685	COG0840	transmembrane signaling receptor activity
AL539_RS05690	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL539_RS05720	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AL539_RS05735	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AL539_RS05740	COG3108	Peptidase M15
AL539_RS05745	COG2989	Protein conserved in bacteria
AL539_RS05770	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AL539_RS05780	COG3088	subunit of a heme lyase
AL539_RS05780	COG4235	cytochrome complex assembly
AL539_RS05790	COG1138	Cytochrome C-type biogenesis protein
AL539_RS05795	COG3301	Polysulphide reductase, NrfD
AL539_RS05800	COG0437	4 iron, 4 sulfur cluster binding
AL539_RS05810	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
AL539_RS05830	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AL539_RS05840	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AL539_RS05870	COG0019	diaminopimelate decarboxylase activity
AL539_RS05910	COG0322	excinuclease ABC activity
AL539_RS05915	COG2197	response regulator
AL539_RS05920	COG0417	DNA replication proofreading
AL539_RS05940	COG1187	pseudouridine synthase activity
AL539_RS05950	COG0009	L-threonylcarbamoyladenylate synthase
AL539_RS05955	COG0613	PHP domain protein
AL539_RS05965	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AL539_RS05970	COG0512	Glutamine amidotransferase of anthranilate synthase
AL539_RS05980	COG0134	indole-3-glycerol-phosphate synthase activity
AL539_RS05980	COG0135	phosphoribosylanthranilate isomerase activity
AL539_RS05990	COG0159	tryptophan synthase activity
AL539_RS05995	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AL539_RS06000	COG0318	PFAM AMP-dependent synthetase and ligase
AL539_RS06010	COG1301	dicarboxylic acid transport
AL539_RS06030	COG2917	probably involved in intracellular septation
AL539_RS06040	COG2350	Protein conserved in bacteria
AL539_RS06050	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AL539_RS06055	COG0583	DNA-binding transcription factor activity
AL539_RS06070	COG5001	Diguanylate cyclase
AL539_RS06075	COG1032	radical SAM domain protein
AL539_RS06100	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AL539_RS06105	COG0463	Glycosyl transferase, family 2
AL539_RS06110	COG0745	RESPONSE REGULATOR receiver
AL539_RS06115	COG5002	protein histidine kinase activity
AL539_RS06115	COG3850	Histidine kinase
AL539_RS06165	COG0577	efflux transmembrane transporter activity
AL539_RS06165	COG1136	(ABC) transporter
AL539_RS06175	COG0577	efflux transmembrane transporter activity
AL539_RS06175	COG1136	(ABC) transporter
AL539_RS06185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL539_RS06205	COG3118	belongs to the thioredoxin family
AL539_RS06210	COG4232	protein-disulfide reductase activity
AL539_RS06245	COG2863	cytochrome
AL539_RS06250	COG3258	Cytochrome c
AL539_RS06255	COG2995	paraquat-inducible protein a
AL539_RS06260	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AL539_RS06260	COG3008	intermembrane lipid transfer
AL539_RS06280	COG4166	transmembrane transport
AL539_RS06290	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AL539_RS06295	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
AL539_RS06305	COG0539	negative regulation of cytoplasmic translation
AL539_RS06310	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AL539_RS06315	COG0616	signal peptide processing
AL539_RS06320	COG1028	Short-chain dehydrogenase reductase Sdr
AL539_RS06335	COG0587	DNA-directed DNA polymerase activity
AL539_RS06340	COG0835	chemotaxis
AL539_RS06340	COG0784	Response regulator, receiver
AL539_RS06345	COG1940	carbohydrate kinase activity
AL539_RS06350	COG0469	pyruvate kinase activity
AL539_RS06355	COG4667	esterase of the alpha-beta hydrolase superfamily
AL539_RS06370	COG0733	neurotransmitter:sodium symporter activity
AL539_RS06385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL539_RS06385	COG1263	PTS System
AL539_RS06390	COG0084	hydrolase, TatD family'
AL539_RS06395	COG0470	DNA polymerase III
AL539_RS06400	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AL539_RS06405	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AL539_RS06435	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AL539_RS06440	COG0416	fatty acid biosynthetic process
AL539_RS06450	COG1399	metal-binding, possibly nucleic acid-binding protein
AL539_RS06455	COG0424	maF-like protein
AL539_RS06460	COG0564	pseudouridine synthase activity
AL539_RS06470	COG1530	ribonuclease E activity
AL539_RS06480	COG0659	secondary active sulfate transmembrane transporter activity
AL539_RS06485	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AL539_RS06490	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
AL539_RS06500	COG0572	uridine kinase
AL539_RS06505	COG0489	protein tyrosine kinase activity
AL539_RS06510	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL539_RS06510	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL539_RS06535	COG2186	Transcriptional regulator
AL539_RS06540	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AL539_RS06545	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AL539_RS06550	COG3318	Belongs to the UPF0149 family
AL539_RS06550	COG3012	SEC-C Motif Domain Protein
AL539_RS06555	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AL539_RS06560	COG3706	GGDEF domain
AL539_RS06565	COG0366	Alpha amylase catalytic
AL539_RS06570	COG1122	ATPase activity
AL539_RS06575	COG4120	Belongs to the binding-protein-dependent transport system permease family
AL539_RS06585	COG3092	negative regulation of chromosome organization
AL539_RS06590	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AL539_RS06595	COG0280	phosphate acetyltransferase
AL539_RS06595	COG0857	belongs to the CobB CobQ family
AL539_RS06605	COG0435	Glutathione S-transferase
AL539_RS06615	COG0444	Belongs to the ABC transporter superfamily
AL539_RS06620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL539_RS06625	COG0601	transmembrane transport
AL539_RS06640	COG0314	molybdopterin synthase activity
AL539_RS06645	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AL539_RS06650	COG0315	cyclic pyranopterin monophosphate synthase activity
AL539_RS06655	COG0521	Mo-molybdopterin cofactor biosynthetic process
AL539_RS06660	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AL539_RS06665	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AL539_RS06670	COG2198	Histidine kinase
AL539_RS06675	COG2204	response regulator
AL539_RS06680	COG0556	nucleotide-excision repair
AL539_RS06690	COG1882	Formate acetyltransferase
AL539_RS06695	COG4657	Part of a membrane complex involved in electron transport
AL539_RS06700	COG2878	Part of a membrane complex involved in electron transport
AL539_RS06705	COG4656	Part of a membrane complex involved in electron transport
AL539_RS06710	COG4658	electron transport chain
AL539_RS06715	COG4659	FMN binding
AL539_RS06720	COG4660	Part of a membrane complex involved in electron transport
AL539_RS06725	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AL539_RS06730	COG0346	lactoylglutathione lyase activity
AL539_RS06740	COG2885	chlorophyll binding
AL539_RS06750	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AL539_RS06755	COG2056	Na+-H+ antiporter family
AL539_RS06775	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AL539_RS06795	COG1454	alcohol dehydrogenase
AL539_RS06795	COG1012	belongs to the aldehyde dehydrogenase family
AL539_RS06800	COG2095	MarC family integral membrane protein
AL539_RS06805	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AL539_RS06810	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AL539_RS06815	COG1757	Na H antiporter
AL539_RS06830	COG3081	Nucleoid-associated protein
AL539_RS06835	COG3082	Protein of unknown function (DUF1414)
AL539_RS06850	COG0123	including yeast histone deacetylase and acetoin utilization protein
AL539_RS06865	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AL539_RS06870	COG0778	Nitroreductase
AL539_RS06880	COG1902	pentaerythritol trinitrate reductase activity
AL539_RS06880	COG0446	pyridine nucleotide-disulphide oxidoreductase
AL539_RS06885	COG0616	signal peptide processing
AL539_RS06890	COG0252	asparaginase activity
AL539_RS06895	COG3139	Protein of unknown function (DUF1315)
AL539_RS06905	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL539_RS06910	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AL539_RS06925	COG2226	methyltransferase
AL539_RS06945	COG1785	Belongs to the alkaline phosphatase family
AL539_RS06955	COG0346	lactoylglutathione lyase activity
AL539_RS06960	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
AL539_RS06965	COG0668	transmembrane transport
AL539_RS06970	COG2983	Belongs to the UPF0260 family
AL539_RS06975	COG2261	transglycosylase associated protein
AL539_RS06985	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AL539_RS06990	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AL539_RS07005	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AL539_RS07010	COG2832	Protein of unknown function (DUF454)
AL539_RS07020	COG0745	RESPONSE REGULATOR receiver
AL539_RS07025	COG0583	DNA-binding transcription factor activity
AL539_RS07030	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AL539_RS07035	COG1286	toxin biosynthetic process
AL539_RS07040	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
AL539_RS07045	COG0285	dihydrofolate synthase activity
AL539_RS07050	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AL539_RS07060	COG0101	tRNA pseudouridine synthase activity
AL539_RS07070	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AL539_RS07075	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AL539_RS07085	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AL539_RS07090	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AL539_RS07090	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AL539_RS07095	COG0431	NADPH-dependent FMN reductase
AL539_RS07110	COG3101	peptidyl-lysine hydroxylation
AL539_RS07120	COG2860	membrane
AL539_RS07125	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AL539_RS07130	COG2890	protein-(glutamine-N5) methyltransferase activity
AL539_RS07135	COG2840	Smr protein MutS2
AL539_RS07140	COG2062	phosphohistidine phosphatase, SixA
AL539_RS07155	COG1250	3-hydroxyacyl-CoA dehydrogenase
AL539_RS07155	COG1024	Enoyl-CoA hydratase
AL539_RS07160	COG0183	Belongs to the thiolase family
AL539_RS07185	COG2067	long-chain fatty acid transport protein
AL539_RS07215	COG5564	TIM-barrel signal transduction protein
AL539_RS07220	COG5441	Belongs to the UPF0261 family
AL539_RS07235	COG4235	cytochrome complex assembly
AL539_RS07235	COG3088	subunit of a heme lyase
AL539_RS07245	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AL539_RS07250	COG1138	Cytochrome C-type biogenesis protein
AL539_RS07255	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AL539_RS07260	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AL539_RS07265	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AL539_RS07270	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AL539_RS07275	COG4133	protoheme IX ABC transporter activity
AL539_RS07285	COG0835	chemotaxis
AL539_RS07295	COG1192	Involved in chromosome partitioning
AL539_RS07300	COG2201	protein-glutamate methylesterase activity
AL539_RS07305	COG0643	Histidine kinase
AL539_RS07305	COG0784	Response regulator, receiver
AL539_RS07305	COG2198	Histidine kinase
AL539_RS07310	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
AL539_RS07350	COG1987	bacterial-type flagellum assembly
AL539_RS07405	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AL539_RS07415	COG1677	Flagellar hook-basal body complex protein FliE
AL539_RS07435	COG1516	flagellar protein fliS
AL539_RS07445	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AL539_RS07450	COG1334	flagellar protein FlaG
AL539_RS07455	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL539_RS07460	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL539_RS07470	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL539_RS07475	COG2837	iron assimilation
AL539_RS07500	COG1393	Belongs to the ArsC family
AL539_RS07505	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AL539_RS07520	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
AL539_RS07525	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AL539_RS07535	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AL539_RS07550	COG4783	chaperone-mediated protein folding
AL539_RS07555	COG1393	Belongs to the ArsC family
AL539_RS07575	COG2233	PERMEase
AL539_RS07580	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AL539_RS07585	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AL539_RS07590	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AL539_RS07595	COG0121	glutamine amidotransferase
AL539_RS07600	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AL539_RS07605	COG1960	acyl-CoA dehydrogenase activity
AL539_RS07640	COG0328	RNA-DNA hybrid ribonuclease activity
AL539_RS07645	COG2226	methyltransferase
AL539_RS07650	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AL539_RS07655	COG1388	LysM domain
AL539_RS07655	COG0741	lytic transglycosylase activity
AL539_RS07665	COG3021	interspecies interaction between organisms
AL539_RS07670	COG0347	Belongs to the P(II) protein family
AL539_RS07685	COG0825	malonyl-CoA metabolic process
AL539_RS07690	COG0587	DNA-directed DNA polymerase activity
AL539_RS07700	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AL539_RS07705	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AL539_RS07715	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AL539_RS07720	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
AL539_RS07730	COG0750	zinc metalloprotease
AL539_RS07735	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AL539_RS07740	COG0575	Belongs to the CDS family
AL539_RS07745	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AL539_RS07750	COG0233	cytoplasmic translational termination
AL539_RS07755	COG0528	UMP kinase activity
AL539_RS07760	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AL539_RS07765	COG0052	Belongs to the universal ribosomal protein uS2 family
AL539_RS07770	COG0024	Methionine aminopeptidase
AL539_RS07775	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AL539_RS07785	COG0564	pseudouridine synthase activity
AL539_RS07790	COG3098	single-species biofilm formation
AL539_RS07825	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AL539_RS07830	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AL539_RS07855	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AL539_RS07865	COG0254	rRNA binding
AL539_RS07870	COG1720	tRNA m6t6A37 methyltransferase activity
AL539_RS07875	COG0442	prolyl-tRNA aminoacylation
AL539_RS07895	COG0733	neurotransmitter:sodium symporter activity
AL539_RS07910	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AL539_RS07915	COG0514	ATP-dependent DNA helicase (RecQ)
AL539_RS07920	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AL539_RS07940	COG1477	protein flavinylation
AL539_RS07945	COG2871	sodium ion transport
AL539_RS07950	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AL539_RS07955	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AL539_RS07960	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AL539_RS07965	COG1805	sodium ion transport
AL539_RS07970	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AL539_RS07975	COG0271	Belongs to the BolA IbaG family
AL539_RS07980	COG2813	Specifically methylates the guanine in position
AL539_RS07985	COG3056	Lipoprotein
AL539_RS08005	COG1595	DNA-templated transcription, initiation
AL539_RS08025	COG3248	Nucleoside-binding outer membrane protein
AL539_RS08030	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AL539_RS08035	COG0693	protein deglycase activity
AL539_RS08040	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AL539_RS08045	COG3706	GGDEF domain
AL539_RS08050	COG2166	iron-sulfur cluster assembly
AL539_RS08055	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AL539_RS08060	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
AL539_RS08075	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AL539_RS08075	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AL539_RS08095	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AL539_RS08100	COG1074	ATP-dependent DNA helicase activity
AL539_RS08105	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AL539_RS08125	COG3141	response to X-ray
AL539_RS08140	COG2171	N-acyltransferase activity
AL539_RS08145	COG0584	glycerophosphoryl diester phosphodiesterase
AL539_RS08150	COG2271	Major facilitator Superfamily
AL539_RS08160	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AL539_RS08165	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AL539_RS08170	COG1349	DNA-binding transcription factor activity
AL539_RS08175	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AL539_RS08180	COG0598	Magnesium transport protein CorA
AL539_RS08200	COG1609	Transcriptional regulator
AL539_RS08205	COG0583	DNA-binding transcription factor activity
AL539_RS08245	COG1022	Amp-dependent synthetase and ligase
AL539_RS08255	COG0583	DNA-binding transcription factor activity
AL539_RS08260	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AL539_RS08265	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AL539_RS08275	COG0560	Phosphoserine phosphatase
AL539_RS08285	COG0813	purine-nucleoside phosphorylase activity
AL539_RS08290	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
AL539_RS08295	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AL539_RS08300	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AL539_RS08305	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AL539_RS08310	COG0084	hydrolase, TatD family'
AL539_RS08340	COG3153	acetyltransferase
AL539_RS08345	COG3154	lipid carrier protein
AL539_RS08360	COG0826	peptidase U32
AL539_RS08365	COG0826	peptidase U32
AL539_RS08370	COG0534	Mate efflux family protein
AL539_RS08385	COG1185	polyribonucleotide nucleotidyltransferase activity
AL539_RS08390	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AL539_RS08395	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AL539_RS08400	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AL539_RS08405	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AL539_RS08410	COG0195	Participates in both transcription termination and antitermination
AL539_RS08415	COG0779	Required for maturation of 30S ribosomal subunits
AL539_RS08430	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AL539_RS08440	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AL539_RS08445	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AL539_RS08450	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AL539_RS08455	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AL539_RS08460	COG1534	Rna-binding protein
AL539_RS08465	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AL539_RS08470	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AL539_RS08475	COG2027	D-alanyl-D-alanine carboxypeptidase
AL539_RS08485	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AL539_RS08490	COG0739	heme binding
AL539_RS08515	COG0628	permease
AL539_RS08525	COG2205	protein histidine kinase activity
AL539_RS08525	COG0784	Response regulator, receiver
AL539_RS08530	COG0747	negative chemotaxis
AL539_RS08540	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL539_RS08545	COG0444	Belongs to the ABC transporter superfamily
AL539_RS08550	COG4608	Belongs to the ABC transporter superfamily
AL539_RS08560	COG2971	BadF BadG BcrA BcrD
AL539_RS08575	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AL539_RS08580	COG3842	ATPase activity
AL539_RS08590	COG1840	ABC-type Fe3 transport system, periplasmic component
AL539_RS08595	COG0004	ammonium transporteR
AL539_RS08605	COG3112	Uncharacterised protein family (UPF0231)
AL539_RS08610	COG1049	propionate catabolic process, 2-methylcitrate cycle
AL539_RS08615	COG1752	Esterase of the alpha-beta hydrolase superfamily
AL539_RS08620	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AL539_RS08625	COG1643	Atp-dependent helicase
AL539_RS08630	COG1489	DNA binding
AL539_RS08640	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AL539_RS08650	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AL539_RS08655	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AL539_RS08660	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AL539_RS08665	COG1560	Kdo2-lipid A biosynthetic process
AL539_RS08675	COG0842	Transport permease protein
AL539_RS08680	COG1131	(ABC) transporter
AL539_RS08685	COG0659	secondary active sulfate transmembrane transporter activity
AL539_RS08690	COG0288	reversible hydration of carbon dioxide
AL539_RS08705	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL539_RS08710	COG0508	dehydrogenase complex catalyzes the overall conversion of
AL539_RS08715	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AL539_RS08720	COG2186	Transcriptional regulator
AL539_RS08730	COG0157	Belongs to the NadC ModD family
AL539_RS08740	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AL539_RS08745	COG1459	type II secretion system
AL539_RS08755	COG0237	dephospho-CoA kinase activity
AL539_RS08760	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
AL539_RS08765	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AL539_RS08780	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AL539_RS08785	COG0228	four-way junction DNA binding
AL539_RS08790	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AL539_RS08795	COG4137	Cytochrome C assembly protein
AL539_RS08800	COG4536	flavin adenine dinucleotide binding
AL539_RS08805	COG1854	S-ribosylhomocysteine lyase activity
AL539_RS08820	COG0612	Peptidase, M16
AL539_RS08825	COG1238	metal cluster binding
AL539_RS08835	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
AL539_RS08840	COG0511	ligase activity, forming carbon-carbon bonds
AL539_RS08840	COG5016	pyruvate
AL539_RS08845	COG3630	sodium ion export across plasma membrane
AL539_RS08905	COG0527	aspartate kinase activity
AL539_RS08910	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AL539_RS08915	COG2137	regulation of response to DNA damage stimulus
AL539_RS08920	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AL539_RS08925	COG1546	Belongs to the CinA family
AL539_RS08930	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AL539_RS08935	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AL539_RS08945	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AL539_RS08950	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AL539_RS08960	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AL539_RS08965	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AL539_RS08970	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AL539_RS08975	COG0148	phosphopyruvate hydratase activity
AL539_RS08980	COG0504	CTP synthase activity
AL539_RS08985	COG3956	TIGRFAM MazG family protein
AL539_RS08990	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AL539_RS09000	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AL539_RS09015	COG0736	holo-[acyl-carrier-protein] synthase activity
AL539_RS09020	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AL539_RS09025	COG1381	Involved in DNA repair and RecF pathway recombination
AL539_RS09030	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AL539_RS09040	COG0681	Belongs to the peptidase S26 family
AL539_RS09045	COG0481	GTPase activity
AL539_RS09050	COG3086	response to oxidative stress
AL539_RS09065	COG1595	DNA-templated transcription, initiation
AL539_RS09075	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AL539_RS09085	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AL539_RS09090	COG0354	folic acid binding
AL539_RS09105	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AL539_RS09110	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AL539_RS09115	COG3079	Belongs to the UPF0149 family
AL539_RS09125	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
AL539_RS09135	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AL539_RS09140	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AL539_RS09145	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AL539_RS09155	COG0583	DNA-binding transcription factor activity
AL539_RS09170	COG0668	transmembrane transport
AL539_RS09175	COG0191	fructose-bisphosphate aldolase activity
AL539_RS09190	COG4771	TonB-dependent receptor
AL539_RS09195	COG0583	DNA-binding transcription factor activity
AL539_RS09200	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AL539_RS09210	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AL539_RS09225	COG2356	endonuclease I
AL539_RS09230	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AL539_RS09235	COG0189	ligase activity
AL539_RS09240	COG1678	Uncharacterized ACR, COG1678
AL539_RS09245	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AL539_RS09260	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AL539_RS09265	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AL539_RS09270	COG0762	integral membrane protein
AL539_RS09275	COG1872	DUF167
AL539_RS09285	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AL539_RS09290	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AL539_RS09295	COG2066	Belongs to the glutaminase family
AL539_RS09305	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AL539_RS09310	COG1194	a g-specific adenine glycosylase
AL539_RS09330	COG2015	COG2015, Alkyl sulfatase and related hydrolases
AL539_RS09340	COG0154	amidase activity
AL539_RS09350	COG1074	ATP-dependent DNA helicase activity
AL539_RS09445	COG4974	Belongs to the 'phage' integrase family
AL539_RS09455	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AL539_RS09465	COG1194	a g-specific adenine glycosylase
AL539_RS09485	COG2015	COG2015, Alkyl sulfatase and related hydrolases
AL539_RS09495	COG0154	amidase activity
AL539_RS09590	COG4974	Belongs to the 'phage' integrase family
AL539_RS09600	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AL539_RS09615	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AL539_RS09660	COG0840	transmembrane signaling receptor activity
AL539_RS09740	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AL539_RS09745	COG1609	Transcriptional regulator
AL539_RS09750	COG3394	polysaccharide catabolic process
AL539_RS09755	COG1486	melibiose metabolic process
AL539_RS09760	COG1447	Phosphotransferase system cellobiose-specific component IIA
AL539_RS09765	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AL539_RS09770	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AL539_RS09775	COG0726	polysaccharide deacetylase
AL539_RS09785	COG1028	Short-chain dehydrogenase reductase Sdr
AL539_RS09800	COG0795	lipopolysaccharide-transporting ATPase activity
AL539_RS09805	COG0795	lipopolysaccharide-transporting ATPase activity
AL539_RS09810	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AL539_RS09815	COG2927	DNA polymerase III (CHI subunit)
AL539_RS09820	COG0525	valine-tRNA ligase activity
AL539_RS09830	COG0456	acetyltransferase
AL539_RS09860	COG0540	Belongs to the ATCase OTCase family
AL539_RS09865	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
AL539_RS09870	COG0251	oxidation-reduction process
AL539_RS09875	COG0204	Acyl-transferase
AL539_RS09880	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AL539_RS09885	COG5007	Belongs to the BolA IbaG family
AL539_RS09895	COG2854	intermembrane phospholipid transfer
AL539_RS09900	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AL539_RS09905	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AL539_RS09910	COG1127	ABC transporter
AL539_RS09920	COG0517	IMP dehydrogenase activity
AL539_RS09920	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AL539_RS09930	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AL539_RS09935	COG1137	ATPase activity
AL539_RS09945	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AL539_RS09950	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL539_RS09955	COG1660	Displays ATPase and GTPase activities
AL539_RS09960	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL539_RS09965	COG2239	Acts as a magnesium transporter
AL539_RS09970	COG0312	modulator of DNA gyrase
AL539_RS09975	COG3028	Belongs to the UPF0307 family
AL539_RS09980	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AL539_RS09985	COG0564	pseudouridine synthase activity
AL539_RS09995	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AL539_RS10000	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AL539_RS10005	COG0312	modulator of DNA gyrase
AL539_RS10010	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AL539_RS10015	COG3164	Protein of unknown function
AL539_RS10025	COG0424	maF-like protein
AL539_RS10030	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AL539_RS10035	COG1792	Involved in formation and maintenance of cell shape
AL539_RS10040	COG1077	Cell shape determining protein MreB Mrl
AL539_RS10060	COG2199	diguanylate cyclase activity
AL539_RS10060	COG2200	EAL domain
AL539_RS10065	COG0629	single-stranded DNA binding
AL539_RS10080	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AL539_RS10090	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AL539_RS10100	COG0527	aspartate kinase activity
AL539_RS10105	COG1410	methionine synthase
AL539_RS10105	COG0646	methionine synthase
AL539_RS10170	COG0175	sulfate reduction
AL539_RS10175	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AL539_RS10180	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AL539_RS10200	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AL539_RS10205	COG0735	belongs to the Fur family
AL539_RS10215	COG0166	Belongs to the GPI family
AL539_RS10220	COG0432	Pfam Uncharacterised protein family UPF0047
AL539_RS10225	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AL539_RS10250	COG2965	DNA replication, synthesis of RNA primer
AL539_RS10255	COG0360	Binds together with S18 to 16S ribosomal RNA
AL539_RS10260	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AL539_RS10265	COG0338	D12 class N6 adenine-specific DNA methyltransferase
AL539_RS10275	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AL539_RS10280	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AL539_RS10310	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AL539_RS10320	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AL539_RS10320	COG0678	peroxiredoxin activity
AL539_RS10325	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL539_RS10335	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AL539_RS10335	COG0165	Argininosuccinate lyase
AL539_RS10340	COG0137	argininosuccinate synthase activity
AL539_RS10350	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AL539_RS10360	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AL539_RS10370	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AL539_RS10375	COG0460	homoserine dehydrogenase
AL539_RS10375	COG0527	aspartate kinase activity
AL539_RS10380	COG0626	cystathionine gamma-synthase activity
AL539_RS10385	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
AL539_RS10390	COG0281	malic enzyme
AL539_RS10405	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AL539_RS10410	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AL539_RS10430	COG2923	Belongs to the DsrF TusC family
AL539_RS10435	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
AL539_RS10440	COG2964	Protein conserved in bacteria
AL539_RS10445	COG0545	Peptidyl-prolyl cis-trans isomerase
AL539_RS10460	COG1446	asparaginase
AL539_RS10470	COG1047	Peptidyl-prolyl cis-trans
AL539_RS10485	COG2249	NAD(P)H dehydrogenase (quinone) activity
AL539_RS10490	COG0488	(ABC) transporter
AL539_RS10500	COG0429	hydrolase of the alpha beta-hydrolase fold
AL539_RS10510	COG3954	Phosphoribulokinase
AL539_RS10515	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AL539_RS10535	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AL539_RS10540	COG0512	Glutamine amidotransferase of anthranilate synthase
AL539_RS10550	COG0697	spore germination
AL539_RS10560	COG1473	amidohydrolase
AL539_RS10565	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AL539_RS10570	COG0583	DNA-binding transcription factor activity
AL539_RS10585	COG0180	Tryptophanyl-tRNA synthetase
AL539_RS10590	COG0546	phosphoglycolate phosphatase activity
AL539_RS10595	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AL539_RS10600	COG0557	exoribonuclease II activity
AL539_RS10605	COG1959	2 iron, 2 sulfur cluster binding
AL539_RS10610	COG1017	nitric oxide dioxygenase activity
AL539_RS10610	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AL539_RS10615	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
AL539_RS10625	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AL539_RS10630	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
AL539_RS10635	COG0330	HflC and HflK could
AL539_RS10640	COG0330	HflC and HflK could
AL539_RS10645	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AL539_RS10655	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AL539_RS10660	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AL539_RS10670	COG0802	atpase or kinase
AL539_RS10680	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AL539_RS10745	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AL539_RS10750	COG1162	GTPase activity
AL539_RS10755	COG0688	phosphatidylethanolamine metabolic process
AL539_RS10760	COG0471	metal ion transport
AL539_RS10760	COG3273	potassium ion transport
AL539_RS10770	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AL539_RS10775	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AL539_RS10780	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AL539_RS10785	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AL539_RS10790	COG1045	serine acetyltransferase
AL539_RS10795	COG4942	peptidase
AL539_RS10815	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
AL539_RS10820	COG1053	succinate dehydrogenase
AL539_RS10825	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AL539_RS10830	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
AL539_RS10835	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
AL539_RS10850	COG1509	lysine 2,3-aminomutase activity
AL539_RS10855	COG1285	pathogenesis
AL539_RS10865	COG0459	protein refolding
AL539_RS10875	COG0534	Mate efflux family protein
AL539_RS10880	COG0205	6-phosphofructokinase activity
AL539_RS10890	COG3678	ATP-independent chaperone mediated protein folding
AL539_RS10895	COG0745	RESPONSE REGULATOR receiver
AL539_RS10900	COG2205	protein histidine kinase activity
AL539_RS10910	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AL539_RS10915	COG3030	protein affecting phage T7 exclusion by the F plasmid
AL539_RS10920	COG1027	Aspartate ammonia-lyase
AL539_RS10925	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AL539_RS10930	COG4232	protein-disulfide reductase activity
AL539_RS10940	COG3263	regulation of cellular component size
AL539_RS10950	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AL539_RS10975	COG2814	Major facilitator Superfamily
AL539_RS10990	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AL539_RS10995	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AL539_RS11000	COG0511	ligase activity, forming carbon-carbon bonds
AL539_RS11005	COG0439	Biotin carboxylase
AL539_RS11015	COG2264	protein methyltransferase activity
AL539_RS11020	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AL539_RS11025	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AL539_RS11035	COG0488	(ABC) transporter
AL539_RS11100	COG1982	Orn Lys Arg decarboxylase major
AL539_RS11105	COG0531	amino acid
AL539_RS11115	COG3710	Transcriptional regulator
AL539_RS11120	COG0789	Transcriptional regulator
AL539_RS11135	COG0151	Belongs to the GarS family
AL539_RS11150	COG1253	flavin adenine dinucleotide binding
AL539_RS11155	COG3068	Protein conserved in bacteria
AL539_RS11165	COG1573	uracil-dna glycosylase
AL539_RS11170	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AL539_RS11175	COG2816	NAD+ diphosphatase activity
AL539_RS11180	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
AL539_RS11185	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AL539_RS11190	COG0085	RNA polymerase activity
AL539_RS11195	COG0222	ribosome binding
AL539_RS11200	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AL539_RS11215	COG0250	Participates in transcription elongation, termination and antitermination
AL539_RS11220	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AL539_RS11230	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AL539_RS11260	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AL539_RS11260	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AL539_RS11265	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AL539_RS11275	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AL539_RS11355	COG4206	TonB-dependent receptor
AL539_RS11375	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL539_RS11380	COG0534	Mate efflux family protein
AL539_RS11385	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
AL539_RS11395	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AL539_RS11405	COG2937	Belongs to the GPAT DAPAT family
AL539_RS11410	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AL539_RS11415	COG3161	chorismate lyase activity
AL539_RS11420	COG1580	Controls the rotational direction of flagella during chemotaxis
AL539_RS11425	COG0705	Rhomboid family
AL539_RS11430	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AL539_RS11445	COG2177	Part of the ABC transporter FtsEX involved in
AL539_RS11450	COG2884	Cell division ATP-binding protein ftsE
AL539_RS11455	COG0552	protein localization to endoplasmic reticulum
AL539_RS11460	COG0742	ribosomal rna small subunit methyltransferase
AL539_RS11470	COG2095	MarC family integral membrane protein
AL539_RS11515	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AL539_RS11520	COG0640	Transcriptional regulator
AL539_RS11525	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AL539_RS11530	COG1280	lysine exporter protein (LysE YggA)
AL539_RS11535	COG2267	carboxylic ester hydrolase activity
AL539_RS11540	COG0561	phosphatase activity
AL539_RS11555	COG3148	PFAM DTW domain containing protein
AL539_RS11560	COG3287	FIST C domain
AL539_RS11560	COG2199	diguanylate cyclase activity
AL539_RS11560	COG2200	EAL domain
AL539_RS11565	COG1011	Hydrolase
AL539_RS11570	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AL539_RS11585	COG0019	diaminopimelate decarboxylase activity
AL539_RS11595	COG1965	Belongs to the frataxin family
AL539_RS11600	COG3072	Adenylate cyclase
AL539_RS11605	COG0181	hydroxymethylbilane synthase activity
AL539_RS11610	COG1587	Uroporphyrinogen-III synthase
AL539_RS11615	COG2959	enzyme of heme biosynthesis
AL539_RS11620	COG3071	HemY protein
AL539_RS11665	COG0633	Ferredoxin
AL539_RS11670	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AL539_RS11685	COG3118	belongs to the thioredoxin family
AL539_RS11690	COG0513	Belongs to the DEAD box helicase family
AL539_RS11695	COG0248	Ppx GppA phosphatase
AL539_RS11705	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AL539_RS11715	COG0514	ATP-dependent DNA helicase (RecQ)
AL539_RS11720	COG2962	Rard protein
AL539_RS11730	COG1280	lysine exporter protein (LysE YggA)
AL539_RS11735	COG0405	Gamma-glutamyltransferase
AL539_RS11745	COG0210	DNA helicase
AL539_RS11755	COG3220	belongs to the UPF0276 family
AL539_RS11785	COG0006	proline dipeptidase activity
AL539_RS11785	COG0006	proline dipeptidase activity
AL539_RS11800	COG2104	thiamine diphosphate biosynthetic process
AL539_RS11805	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AL539_RS11825	COG2132	Multicopper oxidase
AL539_RS11955	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AL539_RS11970	COG0408	coproporphyrinogen oxidase activity
AL539_RS11975	COG0009	L-threonylcarbamoyladenylate synthase
AL539_RS11980	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AL539_RS11985	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AL539_RS11990	COG0551	DNA topoisomerase type I activity
AL539_RS11995	COG2922	Belongs to the Smg family
AL539_RS12000	COG0758	DNA mediated transformation
AL539_RS12010	COG0242	peptide deformylase activity
AL539_RS12015	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AL539_RS12020	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AL539_RS12020	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AL539_RS12025	COG0569	domain protein
AL539_RS12030	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AL539_RS12040	COG1272	protein, Hemolysin III
AL539_RS12045	COG4326	sporulation control protein
AL539_RS12055	COG3084	Protein conserved in bacteria
AL539_RS12065	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AL539_RS12070	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AL539_RS12075	COG0204	Acyl-transferase
AL539_RS12085	COG0606	chelatase, subunit chli
AL539_RS12095	COG3978	acetolactate synthase activity
AL539_RS12100	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AL539_RS12105	COG0129	dihydroxy-acid dehydratase activity
AL539_RS12115	COG0583	DNA-binding transcription factor activity
AL539_RS12120	COG2814	Major facilitator Superfamily
AL539_RS12130	COG0765	amino acid transport
AL539_RS12140	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AL539_RS12145	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AL539_RS12150	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AL539_RS12155	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AL539_RS12160	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AL539_RS12165	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AL539_RS12175	COG0356	it plays a direct role in the translocation of protons across the membrane
AL539_RS12180	COG3312	ion transport
AL539_RS12185	COG1475	DNA binding
AL539_RS12190	COG1192	Involved in chromosome partitioning
AL539_RS12195	COG0357	Ribosomal RNA small subunit methyltransferase G
AL539_RS12200	COG0445	tRNA wobble uridine modification
AL539_RS12210	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AL539_RS12220	COG0706	membrane insertase activity
AL539_RS12230	COG0594	ribonuclease P activity
AL539_RS12240	COG1126	abc transporter atp-binding protein
AL539_RS12260	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AL539_RS12265	COG0592	DNA-directed DNA polymerase activity
AL539_RS12275	COG0187	DNA topoisomerase II activity
AL539_RS12295	COG0071	Belongs to the small heat shock protein (HSP20) family
AL539_RS12300	COG3977	Valine--pyruvate aminotransferase
AL539_RS12305	COG0366	Alpha amylase catalytic
AL539_RS12320	COG2119	membrane
AL539_RS12330	COG0425	Belongs to the sulfur carrier protein TusA family
AL539_RS12345	COG0604	alcohol dehydrogenase
AL539_RS12350	COG0183	Belongs to the thiolase family
AL539_RS12360	COG1739	Uncharacterized protein family UPF0029
AL539_RS12365	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AL539_RS12410	COG0583	DNA-binding transcription factor activity
AL539_RS12415	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AL539_RS12420	COG2960	long-chain fatty acid transporting porin activity
AL539_RS12425	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL539_RS12430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL539_RS12490	COG4166	transmembrane transport
AL539_RS12495	COG0601	transmembrane transport
AL539_RS12500	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL539_RS12515	COG1609	Transcriptional regulator
AL539_RS12520	COG0583	DNA-binding transcription factor activity
AL539_RS12535	COG0129	dihydroxy-acid dehydratase activity
AL539_RS12540	COG3265	gluconokinase activity
AL539_RS12545	COG2610	gluconate transmembrane transporter activity
AL539_RS12550	COG0800	Aldolase
AL539_RS12555	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AL539_RS12560	COG0583	DNA-binding transcription factor activity
AL539_RS12565	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL539_RS12570	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AL539_RS12580	COG1522	sequence-specific DNA binding
AL539_RS12585	COG5002	protein histidine kinase activity
AL539_RS12585	COG5001	Diguanylate cyclase
AL539_RS12605	COG0589	response to stress
AL539_RS12610	COG1528	Iron-storage protein
AL539_RS12620	COG2081	HI0933 family
AL539_RS12650	COG1597	lipid kinase activity
AL539_RS12680	COG0628	permease
AL539_RS12695	COG1322	Protein conserved in bacteria
AL539_RS12700	COG2226	methyltransferase
AL539_RS12705	COG3165	ubiquinone biosynthetic process from chorismate
AL539_RS12710	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AL539_RS12720	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AL539_RS12725	COG0805	protein transport
AL539_RS12740	COG0084	hydrolase, TatD family'
AL539_RS12755	COG0456	acetyltransferase
AL539_RS12765	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL539_RS12765	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL539_RS12770	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AL539_RS12805	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AL539_RS12815	COG2204	response regulator
AL539_RS12820	COG3852	Histidine kinase
AL539_RS12830	COG0174	glutamine synthetase
AL539_RS12835	COG1217	gtp-binding protein TYPA
AL539_RS12840	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AL539_RS12850	COG1295	ribonuclease BN
AL539_RS12855	COG1490	D-aminoacyl-tRNA deacylase activity
AL539_RS12860	COG0456	acetyltransferase
AL539_RS12870	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AL539_RS12875	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AL539_RS12880	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AL539_RS12885	COG3031	protein transport across the cell outer membrane
AL539_RS12895	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AL539_RS12900	COG1459	type II secretion system
AL539_RS12905	COG2165	general secretion pathway protein
AL539_RS12910	COG2165	general secretion pathway protein
AL539_RS12915	COG2165	general secretion pathway protein
AL539_RS12920	COG4795	General secretion pathway protein
AL539_RS12925	COG3156	type II secretion system protein K
AL539_RS12930	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
AL539_RS12935	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
AL539_RS12945	COG1218	3'(2'),5'-bisphosphate nucleotidase
AL539_RS12950	COG0494	nUDIX hydrolase
AL539_RS12960	COG1040	competence protein
AL539_RS12975	COG2183	response to ionizing radiation
AL539_RS12985	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AL539_RS13005	COG2233	PERMEase
AL539_RS13010	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AL539_RS13015	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AL539_RS13020	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AL539_RS13025	COG1758	RNA polymerase activity
AL539_RS13030	COG0194	GDP metabolic process
AL539_RS13050	COG0848	biopolymer transport protein
AL539_RS13055	COG0811	peptide transport
AL539_RS13080	COG4174	ABC transporter (Permease)
AL539_RS13085	COG4239	(ABC) transporter, permease
AL539_RS13090	COG0747	negative chemotaxis
AL539_RS13095	COG0444	Belongs to the ABC transporter superfamily
AL539_RS13100	COG4608	Belongs to the ABC transporter superfamily
AL539_RS13110	COG1561	YicC-like family, N-terminal region
AL539_RS13120	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AL539_RS13125	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AL539_RS13130	COG1560	Kdo2-lipid A biosynthetic process
AL539_RS13135	COG1309	transcriptional regulator
AL539_RS13140	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AL539_RS13155	COG2003	Belongs to the UPF0758 family
AL539_RS13200	COG0859	PFAM glycosyl transferase family 9
AL539_RS13205	COG0438	transferase activity, transferring glycosyl groups
AL539_RS13210	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AL539_RS13215	COG3642	lipopolysaccharide core region biosynthetic process
AL539_RS13260	COG1519	Transferase
AL539_RS13265	COG0859	PFAM glycosyl transferase family 9
AL539_RS13270	COG1560	Kdo2-lipid A biosynthetic process
AL539_RS13280	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL539_RS13335	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AL539_RS13360	COG1215	transferase activity, transferring glycosyl groups
AL539_RS13370	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AL539_RS13375	COG0110	maltose O-acetyltransferase activity
AL539_RS13380	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AL539_RS13395	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AL539_RS13405	COG0149	triose-phosphate isomerase activity
AL539_RS13430	COG1494	fructose-1,6-bisphosphatase
AL539_RS13440	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AL539_RS13445	COG1575	Belongs to the MenA family. Type 1 subfamily
AL539_RS13475	COG2003	Belongs to the UPF0758 family
AL539_RS13485	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AL539_RS13490	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AL539_RS13500	COG1609	Transcriptional regulator
AL539_RS13505	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AL539_RS13515	COG0254	rRNA binding
AL539_RS13525	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AL539_RS13530	COG0088	Forms part of the polypeptide exit tunnel
AL539_RS13540	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AL539_RS13545	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AL539_RS13550	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AL539_RS13555	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AL539_RS13565	COG0255	Belongs to the universal ribosomal protein uL29 family
AL539_RS13570	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AL539_RS13580	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AL539_RS13585	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AL539_RS13595	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AL539_RS13600	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AL539_RS13615	COG1841	ribosomal large subunit assembly
AL539_RS13620	COG0200	Binds to the 23S rRNA
AL539_RS13625	COG0201	protein transport
AL539_RS13630	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AL539_RS13635	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AL539_RS13640	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AL539_RS13650	COG0202	RNA polymerase activity
AL539_RS13655	COG0203	ribosomal protein L17
AL539_RS13665	COG0545	Peptidyl-prolyl cis-trans isomerase
AL539_RS13675	COG2153	protein acetylation
AL539_RS13680	COG0513	Belongs to the DEAD box helicase family
AL539_RS13695	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AL539_RS13695	COG1648	precorrin-2 dehydrogenase activity
AL539_RS13700	COG0175	sulfate reduction
AL539_RS13705	COG2895	sulfate adenylyltransferase (ATP) activity
AL539_RS13710	COG0471	metal ion transport
AL539_RS13710	COG3273	potassium ion transport
AL539_RS13715	COG0529	Catalyzes the synthesis of activated sulfate
AL539_RS13735	COG4181	ATPase activity
AL539_RS13750	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
AL539_RS13760	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL539_RS13765	COG0729	surface antigen
AL539_RS13770	COG2911	Protein conserved in bacteria
AL539_RS13775	COG2105	PFAM AIG2 family protein
AL539_RS13795	COG0840	transmembrane signaling receptor activity
AL539_RS13830	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AL539_RS13835	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AL539_RS13845	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AL539_RS13850	COG0163	prenyltransferase activity
AL539_RS13860	COG1178	ABC-type Fe3 transport system permease component
AL539_RS13865	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
AL539_RS13870	COG0583	DNA-binding transcription factor activity
AL539_RS13875	COG1902	pentaerythritol trinitrate reductase activity
AL539_RS13895	COG2358	TRAP transporter, solute receptor (TAXI family
AL539_RS13920	COG0142	geranyltranstransferase activity
AL539_RS13925	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AL539_RS13935	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AL539_RS13940	COG2966	Psort location CytoplasmicMembrane, score
AL539_RS13955	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AL539_RS13960	COG2967	ApaG domain
AL539_RS13965	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AL539_RS13970	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AL539_RS13975	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AL539_RS13980	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AL539_RS13985	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AL539_RS14005	COG0473	3-isopropylmalate dehydrogenase activity
AL539_RS14010	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AL539_RS14035	COG0583	DNA-binding transcription factor activity
AL539_RS14040	COG1022	Amp-dependent synthetase and ligase
AL539_RS14045	COG0028	Belongs to the TPP enzyme family
AL539_RS14050	COG0440	acetolactate synthase activity
AL539_RS14065	COG0469	pyruvate kinase activity
AL539_RS14070	COG1349	DNA-binding transcription factor activity
AL539_RS14075	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AL539_RS14110	COG0732	type I restriction modification DNA specificity domain
AL539_RS14135	COG2376	Dihydroxyacetone kinase
AL539_RS14140	COG1461	Dihydroxyacetone kinase
AL539_RS14155	COG3722	fumarate hydratase activity
AL539_RS14165	COG2213	PTS system mannitol-specific
AL539_RS14165	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL539_RS14205	COG1278	Cold shock
AL539_RS14220	COG1278	Cold shock
AL539_RS14230	COG3550	peptidyl-serine autophosphorylation
AL539_RS14260	COG0210	DNA helicase
AL539_RS14280	COG3550	peptidyl-serine autophosphorylation
AL539_RS14300	COG0358	DNA primase activity
AL539_RS14305	COG1610	YqeY-like protein
AL539_RS14310	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AL539_RS14315	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AL539_RS14320	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AL539_RS14325	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AL539_RS14330	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AL539_RS14335	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AL539_RS14340	COG1968	undecaprenyl-diphosphatase activity
AL539_RS14350	COG3409	Peptidoglycan-binding domain 1 protein
AL539_RS14350	COG3267	Type II secretory pathway component ExeA
AL539_RS14360	COG0405	Gamma-glutamyltransferase
AL539_RS14365	COG4991	sh3 domain protein
AL539_RS14370	COG0306	phosphate transporter
AL539_RS14375	COG1392	Phosphate transport regulator
AL539_RS14380	COG3025	triphosphatase activity
AL539_RS14395	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AL539_RS14400	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AL539_RS14400	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AL539_RS14405	COG1538	Outer membrane efflux protein
AL539_RS14410	COG0494	nUDIX hydrolase
AL539_RS14415	COG3151	Protein conserved in bacteria
AL539_RS14425	COG3150	esterase
AL539_RS14435	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AL539_RS14440	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AL539_RS14450	COG3105	Protein conserved in bacteria
AL539_RS14460	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AL539_RS14475	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AL539_RS14480	COG0723	plastoquinol--plastocyanin reductase activity
AL539_RS14485	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AL539_RS14490	COG2857	Cytochrome c1
AL539_RS14495	COG0625	glutathione transferase activity
AL539_RS14500	COG2969	positive regulation of protein catabolic process
AL539_RS14505	COG2823	Periplasmic or secreted lipoprotein
AL539_RS14510	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AL539_RS14525	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AL539_RS14545	COG3116	cell division
AL539_RS14550	COG0768	penicillin binding
AL539_RS14555	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AL539_RS14560	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AL539_RS14565	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AL539_RS14570	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AL539_RS14575	COG0772	Belongs to the SEDS family
AL539_RS14590	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AL539_RS14595	COG0849	cell division
AL539_RS14600	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AL539_RS14605	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AL539_RS14615	COG0653	protein targeting
AL539_RS14620	COG0494	nUDIX hydrolase
AL539_RS14630	COG0505	Belongs to the CarA family
AL539_RS14635	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AL539_RS14650	COG0730	response to heat
AL539_RS14655	COG0583	DNA-binding transcription factor activity
AL539_RS14660	COG2860	membrane
AL539_RS14675	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AL539_RS14685	COG0493	'glutamate synthase
AL539_RS14690	COG0070	glutamate synthase
AL539_RS14690	COG0069	glutamate synthase activity
AL539_RS14690	COG0067	glutamate synthase
AL539_RS14700	COG0067	glutamate synthase
AL539_RS14700	COG0069	glutamate synthase activity
AL539_RS14700	COG0070	glutamate synthase
AL539_RS14705	COG1242	4 iron, 4 sulfur cluster binding
AL539_RS14710	COG4251	negative regulation of phosphorylation
AL539_RS14710	COG3706	GGDEF domain
AL539_RS14710	COG5001	Diguanylate cyclase
AL539_RS14710	COG2203	Gaf domain
AL539_RS14715	COG0784	Response regulator, receiver
AL539_RS14715	COG2198	Histidine kinase
AL539_RS14715	COG5002	protein histidine kinase activity
AL539_RS14725	COG0745	RESPONSE REGULATOR receiver
AL539_RS14740	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AL539_RS14760	COG0083	homoserine kinase activity
AL539_RS14765	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AL539_RS14775	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
AL539_RS14780	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AL539_RS14790	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AL539_RS14805	COG1115	amino acid carrier protein
AL539_RS14810	COG3022	response to hydroperoxide
AL539_RS14815	COG0513	Belongs to the DEAD box helicase family
AL539_RS14820	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AL539_RS14830	COG0716	FMN binding
AL539_RS14835	COG4974	Belongs to the 'phage' integrase family
AL539_RS14840	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AL539_RS14845	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AL539_RS14860	COG2204	response regulator
AL539_RS14870	COG0667	Aldo Keto reductase
AL539_RS14895	COG0730	response to heat
AL539_RS14900	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AL539_RS14905	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AL539_RS14915	COG1283	sodium-dependent phosphate transmembrane transporter activity
AL539_RS14920	COG0583	DNA-binding transcription factor activity
AL539_RS14925	COG0640	Transcriptional regulator
AL539_RS14930	COG0268	Binds directly to 16S ribosomal RNA
AL539_RS14935	COG0728	peptidoglycan biosynthetic process
AL539_RS14940	COG0196	riboflavin kinase activity
AL539_RS14955	COG1047	Peptidyl-prolyl cis-trans
AL539_RS14960	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AL539_RS14970	COG3279	Response regulator of the LytR AlgR family
AL539_RS14975	COG3275	phosphorelay sensor kinase activity
AL539_RS14980	COG1966	Carbon starvation protein
AL539_RS15000	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AL539_RS15005	COG1472	Belongs to the glycosyl hydrolase 3 family
AL539_RS15010	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AL539_RS15015	COG0287	Prephenate dehydrogenase
AL539_RS15015	COG1605	Chorismate mutase
AL539_RS15020	COG0739	heme binding
AL539_RS15030	COG0488	(ABC) transporter
AL539_RS15040	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
AL539_RS15045	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
AL539_RS15050	COG1605	Chorismate mutase
AL539_RS15050	COG0077	Prephenate dehydratase
AL539_RS15055	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AL539_RS15065	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL539_RS15070	COG0564	pseudouridine synthase activity
AL539_RS15080	COG0542	response to heat
AL539_RS15145	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AL539_RS15150	COG0826	peptidase U32
AL539_RS15155	COG2974	May be involved in recombination
AL539_RS15165	COG0745	RESPONSE REGULATOR receiver
AL539_RS15170	COG5002	protein histidine kinase activity
AL539_RS15180	COG0248	Ppx GppA phosphatase
AL539_RS15185	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AL539_RS15190	COG0573	inorganic phosphate transmembrane transporter activity
AL539_RS15195	COG0581	inorganic phosphate transmembrane transporter activity
AL539_RS15200	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AL539_RS15205	COG0704	Plays a role in the regulation of phosphate uptake
AL539_RS15215	COG3142	Participates in the control of copper homeostasis
AL539_RS15220	COG0450	alkyl hydroperoxide reductase
AL539_RS15225	COG0583	DNA-binding transcription factor activity
AL539_RS15230	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AL539_RS15240	COG0517	IMP dehydrogenase activity
AL539_RS15250	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AL539_RS15260	COG1862	Preprotein translocase
AL539_RS15265	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL539_RS15270	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL539_RS15285	COG0483	inositol monophosphate 1-phosphatase activity
AL539_RS15290	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
AL539_RS15300	COG1104	cysteine desulfurase activity
AL539_RS15305	COG0822	iron-sulfur transferase activity
AL539_RS15320	COG0443	Heat shock 70 kDa protein
AL539_RS15325	COG0633	Ferredoxin
AL539_RS15330	COG2975	iron-sulfur cluster assembly
AL539_RS15340	COG0105	UTP biosynthetic process
AL539_RS15355	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AL539_RS15360	COG0124	histidyl-tRNA synthetase
AL539_RS15365	COG2976	Protein conserved in bacteria
AL539_RS15370	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL539_RS15375	COG1160	GTP binding
AL539_RS15395	COG0517	IMP dehydrogenase activity
AL539_RS15395	COG0516	GMP reductase activity
AL539_RS15400	COG0519	Catalyzes the synthesis of GMP from XMP
AL539_RS15400	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AL539_RS15405	COG1757	Na H antiporter
AL539_RS15415	COG1584	GPR1 FUN34 yaaH family protein
AL539_RS15420	COG1115	amino acid carrier protein
AL539_RS15435	COG2873	o-acetylhomoserine
AL539_RS15440	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AL539_RS15460	COG3153	acetyltransferase
AL539_RS15460	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AL539_RS15465	COG0583	DNA-binding transcription factor activity
AL539_RS15510	COG2200	EAL domain
AL539_RS15510	COG2199	diguanylate cyclase activity
AL539_RS15510	COG3287	FIST C domain
AL539_RS15515	COG5001	Diguanylate cyclase
AL539_RS15515	COG3300	MHYT domain
AL539_RS15540	COG2801	Transposase and inactivated derivatives
AL539_RS15545	COG3706	GGDEF domain
AL539_RS15565	COG4974	Belongs to the 'phage' integrase family
AL539_RS15585	COG3550	peptidyl-serine autophosphorylation
AL539_RS15655	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AL539_RS15660	COG0732	type I restriction modification DNA specificity domain
AL539_RS15700	COG0582	viral genome integration into host DNA
AL539_RS15710	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AL539_RS15715	COG2867	negative regulation of translational initiation
AL539_RS15720	COG2914	Belongs to the UPF0125 (RnfH) family
AL539_RS15725	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL539_RS15735	COG0497	DNA recombination
AL539_RS15745	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AL539_RS15750	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AL539_RS15755	COG1301	dicarboxylic acid transport
AL539_RS15765	COG0484	heat shock protein binding
AL539_RS15795	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AL539_RS15810	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AL539_RS15815	COG0047	phosphoribosylformylglycinamidine synthase activity
AL539_RS15815	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AL539_RS15830	COG1629	transport
AL539_RS15845	COG2195	Cleaves the N-terminal amino acid of tripeptides
AL539_RS15850	COG2252	PERMEase
AL539_RS15855	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AL539_RS15860	COG1073	alpha beta
AL539_RS15870	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AL539_RS15875	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AL539_RS15880	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AL539_RS15885	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AL539_RS15885	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AL539_RS15900	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AL539_RS15910	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AL539_RS15915	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AL539_RS15925	COG0142	geranyltranstransferase activity
AL539_RS15930	COG1722	exodeoxyribonuclease VII activity
AL539_RS15935	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AL539_RS15945	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AL539_RS15945	COG0301	tRNA thio-modification
AL539_RS15950	COG0583	DNA-binding transcription factor activity
AL539_RS15960	COG2363	Small membrane protein
AL539_RS15970	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL539_RS15975	COG1611	Belongs to the LOG family
AL539_RS15990	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AL539_RS15990	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AL539_RS16000	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
AL539_RS16005	COG1464	Belongs to the NlpA lipoprotein family
AL539_RS16010	COG2011	ABC-type metal ion transport system permease component
AL539_RS16015	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AL539_RS16020	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AL539_RS16030	COG1263	PTS System
AL539_RS16030	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL539_RS16035	COG0366	Alpha amylase catalytic
AL539_RS16050	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AL539_RS16055	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AL539_RS16060	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AL539_RS16065	COG0321	lipoyl(octanoyl) transferase activity
AL539_RS16075	COG1686	Belongs to the peptidase S11 family
AL539_RS16080	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AL539_RS16085	COG0772	Belongs to the SEDS family
AL539_RS16090	COG0768	penicillin binding
AL539_RS16095	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AL539_RS16100	COG0799	negative regulation of ribosome biogenesis
AL539_RS16105	COG1466	dna polymerase III delta subunit
AL539_RS16110	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
AL539_RS16115	COG0495	leucyl-tRNA aminoacylation
AL539_RS16120	COG2888	peptidyl-tyrosine sulfation
AL539_RS16125	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AL539_RS16130	COG4535	Mg2 and Co2 transporter CorC
AL539_RS16135	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AL539_RS16140	COG1702	phosphate starvation-inducible protein PhoH
AL539_RS16145	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AL539_RS16155	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AL539_RS16265	COG0012	GTP binding
AL539_RS16270	COG0193	aminoacyl-tRNA hydrolase activity
AL539_RS16275	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AL539_RS16280	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AL539_RS16285	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AL539_RS16290	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AL539_RS16300	COG2890	protein-(glutamine-N5) methyltransferase activity
AL539_RS16305	COG3094	Invasion gene expression up-regulator, SirB
AL539_RS16310	COG2912	Transglutaminase-like superfamily
AL539_RS16315	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AL539_RS16320	COG0737	Belongs to the 5'-nucleotidase family
AL539_RS16325	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AL539_RS16330	COG1187	pseudouridine synthase activity
AL539_RS16335	COG2840	Smr protein MutS2
AL539_RS16375	COG2608	mercury ion transmembrane transporter activity
AL539_RS16375	COG2217	Heavy metal translocating P-type atpase
AL539_RS16390	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
AL539_RS16445	COG0835	chemotaxis
AL539_RS16445	COG0784	Response regulator, receiver
AL539_RS16450	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AL539_RS16455	COG1815	bacterial-type flagellum-dependent cell motility
AL539_RS16460	COG1558	bacterial-type flagellum-dependent cell motility
AL539_RS16470	COG1749	Flagellar hook protein flgE
AL539_RS16475	COG4787	bacterial-type flagellum-dependent cell motility
AL539_RS16485	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AL539_RS16490	COG1706	bacterial-type flagellum-dependent cell motility
AL539_RS16495	COG1705	Flagellar rod assembly protein muramidase FlgJ
AL539_RS16495	COG3951	Flagellar rod assembly protein muramidase FlgJ
AL539_RS16505	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL539_RS16510	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL539_RS16520	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL539_RS16525	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL539_RS16530	COG2190	(PTS) system
AL539_RS16535	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AL539_RS16540	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL539_RS16550	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AL539_RS16555	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
AL539_RS16560	COG3115	cell septum assembly
AL539_RS16565	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AL539_RS16585	COG0330	HflC and HflK could
AL539_RS16590	COG3118	belongs to the thioredoxin family
AL539_RS16600	COG0300	oxidoreductase activity
AL539_RS16605	COG1090	epimerase
AL539_RS16635	COG0622	Phosphoesterase
AL539_RS16655	COG3710	Transcriptional regulator
AL539_RS16660	COG0326	Molecular chaperone. Has ATPase activity
AL539_RS16670	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AL539_RS16675	COG3104	oligopeptide transport
AL539_RS16680	COG0250	Participates in transcription elongation, termination and antitermination
AL539_RS16685	COG0367	asparagine synthase
AL539_RS16690	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AL539_RS16690	COG4651	solute:proton antiporter activity
AL539_RS16695	COG1846	Transcriptional regulator
AL539_RS16695	COG1940	carbohydrate kinase activity
AL539_RS16700	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AL539_RS16710	COG1263	PTS System
AL539_RS16710	COG2190	(PTS) system
AL539_RS16710	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL539_RS16715	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AL539_RS16720	COG0735	belongs to the Fur family
AL539_RS16730	COG0716	FMN binding
AL539_RS16740	COG0596	Alpha beta hydrolase
AL539_RS16745	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
AL539_RS16750	COG0033	Phosphoglucomutase
AL539_RS16760	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AL539_RS16775	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AL539_RS16780	COG1053	succinate dehydrogenase
AL539_RS16785	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AL539_RS16790	COG0567	Dehydrogenase, E1 component
AL539_RS16795	COG0508	dehydrogenase complex catalyzes the overall conversion of
AL539_RS16800	COG0045	succinate-CoA ligase (ADP-forming) activity
AL539_RS16810	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AL539_RS16815	COG1121	(ABC) transporter
AL539_RS16820	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
AL539_RS16830	COG1918	ferrous iron import across plasma membrane
AL539_RS16855	COG0018	arginyl-trna synthetase
AL539_RS16865	COG3102	Protein conserved in bacteria
AL539_RS16870	COG0788	formyltetrahydrofolate deformylase activity
AL539_RS16875	COG1199	ATP-dependent helicase activity
AL539_RS16880	COG1214	PFAM Peptidase M22, glycoprotease
AL539_RS16895	COG2267	carboxylic ester hydrolase activity
AL539_RS16900	COG0318	PFAM AMP-dependent synthetase and ligase
AL539_RS16905	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AL539_RS16910	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AL539_RS16915	COG2894	cell division
AL539_RS16920	COG0850	regulation of cytokinetic process
AL539_RS16925	COG3100	YcgL domain-containing protein
AL539_RS16930	COG2951	lytic endotransglycosylase activity
AL539_RS16940	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AL539_RS16945	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AL539_RS16960	COG1028	Short-chain dehydrogenase reductase Sdr
AL539_RS16970	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AL539_RS16995	COG2986	histidine ammonia-lyase
AL539_RS17000	COG1216	Glycosyl transferase, family 2
AL539_RS17005	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AL539_RS17020	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AL539_RS17025	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AL539_RS17060	COG0513	Belongs to the DEAD box helicase family
AL539_RS17065	COG0569	domain protein
AL539_RS17070	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AL539_RS17085	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AL539_RS17090	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AL539_RS17095	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AL539_RS17100	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AL539_RS17125	COG0544	peptidyl-prolyl cis-trans isomerase activity
AL539_RS17135	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AL539_RS17140	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AL539_RS17145	COG0776	regulation of translation
AL539_RS17150	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AL539_RS17155	COG1555	photosystem II stabilization
AL539_RS17170	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AL539_RS17175	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
AL539_RS17180	COG0436	Aminotransferase
AL539_RS17185	COG1169	isochorismate synthase
AL539_RS17190	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AL539_RS17200	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AL539_RS17220	COG2855	membrane
AL539_RS17225	COG0477	Major facilitator Superfamily
AL539_RS17275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL539_RS17280	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL539_RS17295	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AL539_RS17300	COG1522	sequence-specific DNA binding
AL539_RS17310	COG1946	Acyl-CoA thioesterase
AL539_RS17315	COG3126	Type III secretion system lipoprotein chaperone (YscW)
AL539_RS17340	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AL539_RS17345	COG0517	IMP dehydrogenase activity
AL539_RS17345	COG0516	GMP reductase activity
AL539_RS17370	COG0537	adenosine 5'-monophosphoramidase activity
AL539_RS17395	COG3150	esterase
AL539_RS17400	COG1252	NADH dehydrogenase
AL539_RS17415	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AL539_RS17425	COG4591	ABC-type transport system involved in lipoprotein release permease component
AL539_RS17430	COG1136	(ABC) transporter
AL539_RS17435	COG4591	ABC-type transport system involved in lipoprotein release permease component
AL539_RS17445	COG0658	competence protein
AL539_RS17445	COG2333	competence protein COMEC
AL539_RS17450	COG1132	(ABC) transporter
AL539_RS17470	COG2719	SpoVR family
AL539_RS17475	COG2718	Belongs to the UPF0229 family
AL539_RS17480	COG2766	serine protein kinase
AL539_RS17490	COG3013	Belongs to the UPF0304 family
AL539_RS17500	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AL539_RS17510	COG1882	Formate acetyltransferase
AL539_RS17555	COG0708	Exodeoxyribonuclease III
AL539_RS17565	COG3923	Primosomal replication protein n
AL539_RS17570	COG0730	response to heat
AL539_RS17575	COG1199	ATP-dependent helicase activity
AL539_RS17580	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AL539_RS17585	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
AL539_RS17590	COG1187	pseudouridine synthase activity
AL539_RS17600	COG1278	Cold shock
AL539_RS17605	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AL539_RS17610	COG0542	response to heat
AL539_RS17615	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AL539_RS17620	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AL539_RS17625	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AL539_RS17645	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AL539_RS17650	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AL539_RS17655	COG0297	glycogen (starch) synthase activity
AL539_RS17675	COG3070	regulator of competence-specific genes
AL539_RS17680	COG1609	Transcriptional regulator
AL539_RS17685	COG3381	protein complex oligomerization
AL539_RS17690	COG0745	RESPONSE REGULATOR receiver
AL539_RS17695	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AL539_RS17700	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AL539_RS17705	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
AL539_RS17710	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
AL539_RS17715	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AL539_RS17735	COG0189	ligase activity
AL539_RS17735	COG4067	protein conserved in archaea
AL539_RS17745	COG0500	methyltransferase
AL539_RS17755	COG1801	Protein of unknown function DUF72
AL539_RS17765	COG0217	transcriptional regulatory protein
AL539_RS17770	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AL539_RS17775	COG0632	four-way junction helicase activity
AL539_RS17780	COG2255	four-way junction helicase activity
AL539_RS17785	COG1271	oxidase subunit
AL539_RS17790	COG1294	oxidase, subunit
AL539_RS17795	COG4890	Cyd operon protein YbgT
AL539_RS17805	COG0824	Thioesterase
AL539_RS17810	COG0811	peptide transport
AL539_RS17825	COG0823	Involved in the tonB-independent uptake of proteins
AL539_RS17830	COG2885	chlorophyll binding
AL539_RS17835	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
AL539_RS17840	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AL539_RS17850	COG3766	membrane
AL539_RS17860	COG0754	glutathionylspermidine amidase activity
AL539_RS17890	COG0631	protein serine/threonine phosphatase activity
AL539_RS17960	COG0420	3'-5' exonuclease activity
AL539_RS17965	COG0419	ATPase involved in DNA repair
AL539_RS17975	COG3040	lipid binding
AL539_RS17985	COG1288	antiporter activity
AL539_RS17995	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
AL539_RS18010	COG2425	protein containing a von Willebrand factor type A (vWA) domain
AL539_RS18025	COG0583	DNA-binding transcription factor activity
AL539_RS18030	COG0277	FAD linked oxidase domain protein
AL539_RS18045	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AL539_RS18100	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AL539_RS18125	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AL539_RS18130	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AL539_RS18140	COG2116	formate transmembrane transporter activity
AL539_RS18160	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AL539_RS18200	COG3118	belongs to the thioredoxin family
AL539_RS18205	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AL539_RS18230	COG2271	Major facilitator Superfamily
AL539_RS18235	COG3851	Histidine kinase
AL539_RS18240	COG2197	response regulator
AL539_RS18250	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AL539_RS18255	COG0583	DNA-binding transcription factor activity
AL539_RS18265	COG0243	molybdopterin cofactor binding
AL539_RS18280	COG0384	phenazine biosynthesis protein PhzF
AL539_RS18285	COG1794	racemase activity, acting on amino acids and derivatives
AL539_RS18320	COG1328	CTP reductase activity
AL539_RS18325	COG0602	queuosine metabolic process
AL539_RS18330	COG0534	Mate efflux family protein
AL539_RS18335	COG2207	Transcriptional regulator
AL539_RS18345	COG0189	ligase activity
AL539_RS18345	COG4067	protein conserved in archaea
AL539_RS18355	COG3111	PFAM Bacterial OB fold (BOF) protein
AL539_RS18365	COG0725	ABC transporter, periplasmic molybdate-binding protein
AL539_RS18370	COG4149	molybdate abc transporter
AL539_RS18375	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AL539_RS18385	COG4251	negative regulation of phosphorylation
AL539_RS18385	COG3706	GGDEF domain
AL539_RS18385	COG2203	Gaf domain
AL539_RS18385	COG5001	Diguanylate cyclase
AL539_RS18420	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AL539_RS18425	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AL539_RS18450	COG3140	Belongs to the UPF0181 family
AL539_RS18465	COG0583	DNA-binding transcription factor activity
AL539_RS18485	COG0023	Translation Initiation Factor
AL539_RS18495	COG1181	Belongs to the D-alanine--D-alanine ligase family
AL539_RS18505	COG1042	CoA-binding domain protein
AL539_RS18505	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL539_RS18505	COG0045	succinate-CoA ligase (ADP-forming) activity
AL539_RS18510	COG0583	DNA-binding transcription factor activity
AL539_RS18530	COG5001	Diguanylate cyclase
AL539_RS18530	COG3447	MASE1 domain protein
AL539_RS18530	COG5002	protein histidine kinase activity
AL539_RS18535	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AL539_RS18540	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AL539_RS18545	COG1984	allophanate hydrolase subunit 2
AL539_RS18555	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AL539_RS18560	COG4181	ATPase activity
AL539_RS18570	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AL539_RS18575	COG5001	Diguanylate cyclase
AL539_RS18575	COG3300	MHYT domain
AL539_RS18610	COG4533	DNA binding
AL539_RS18620	COG2050	protein possibly involved in aromatic compounds catabolism
AL539_RS18635	COG2067	long-chain fatty acid transport protein
AL539_RS18640	COG2267	carboxylic ester hydrolase activity
AL539_RS18660	COG0861	Integral membrane protein TerC family
AL539_RS18665	COG0737	Belongs to the 5'-nucleotidase family
AL539_RS18670	COG3593	DNA synthesis involved in DNA repair
AL539_RS18680	COG0583	DNA-binding transcription factor activity
AL539_RS18685	COG2116	formate transmembrane transporter activity
AL539_RS18690	COG2353	YceI-like domain
AL539_RS18695	COG3038	cytochrome b561
AL539_RS18715	COG0513	Belongs to the DEAD box helicase family
AL539_RS18720	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
AL539_RS18730	COG0840	transmembrane signaling receptor activity
AL539_RS18740	COG0546	phosphoglycolate phosphatase activity
AL539_RS18755	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL539_RS18760	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AL539_RS18765	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AL539_RS18780	COG2207	Transcriptional regulator
AL539_RS18785	COG1979	alcohol dehydrogenase
AL539_RS18795	COG1126	abc transporter atp-binding protein
AL539_RS18800	COG0765	amino acid transport
AL539_RS18805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL539_RS18810	COG0765	amino acid transport
AL539_RS18815	COG2199	diguanylate cyclase activity
AL539_RS18815	COG2203	Gaf domain
AL539_RS18815	COG2200	EAL domain
AL539_RS18830	COG1609	Transcriptional regulator
AL539_RS18835	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL539_RS18835	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL539_RS18840	COG1105	Belongs to the carbohydrate kinase PfkB family
AL539_RS18845	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL539_RS18845	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL539_RS18845	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
AL539_RS18875	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AL539_RS18885	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AL539_RS18890	COG0509	glycine decarboxylation via glycine cleavage system
AL539_RS18900	COG0346	lactoylglutathione lyase activity
AL539_RS18910	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AL539_RS18915	COG0583	DNA-binding transcription factor activity
AL539_RS18920	COG0697	spore germination
AL539_RS18925	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AL539_RS18955	COG2176	DNA-directed DNA polymerase activity
AL539_RS19005	COG0242	peptide deformylase activity
AL539_RS19040	COG2239	Acts as a magnesium transporter
AL539_RS19060	COG0346	lactoylglutathione lyase activity
AL539_RS19065	COG1902	pentaerythritol trinitrate reductase activity
AL539_RS19075	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AL539_RS19075	COG2755	lipolytic protein G-D-S-L family
AL539_RS19085	COG5642	Protein of unknown function (DUF2384)
AL539_RS19090	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AL539_RS19125	COG2076	Multidrug Resistance protein
AL539_RS19145	COG2962	Rard protein
AL539_RS19160	COG0835	chemotaxis
AL539_RS19160	COG0784	Response regulator, receiver
AL539_RS19170	COG0745	RESPONSE REGULATOR receiver
AL539_RS19180	COG3706	GGDEF domain
AL539_RS19185	COG2197	response regulator
AL539_RS19190	COG3300	MHYT domain
AL539_RS19190	COG5001	Diguanylate cyclase
AL539_RS19195	COG2205	protein histidine kinase activity
AL539_RS19195	COG0784	Response regulator, receiver
AL539_RS19200	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AL539_RS19220	COG0456	acetyltransferase
AL539_RS19220	COG1214	PFAM Peptidase M22, glycoprotease
AL539_RS19230	COG3069	C4-dicarboxylate transmembrane transporter activity
AL539_RS19255	COG3111	PFAM Bacterial OB fold (BOF) protein
AL539_RS19260	COG1597	lipid kinase activity
AL539_RS19265	COG0583	DNA-binding transcription factor activity
AL539_RS19270	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AL539_RS19300	COG0714	Associated with various cellular activities
AL539_RS19305	COG0641	radical SAM
AL539_RS19310	COG3119	arylsulfatase activity
AL539_RS19320	COG3119	arylsulfatase activity
AL539_RS19325	COG0745	RESPONSE REGULATOR receiver
AL539_RS19340	COG2205	protein histidine kinase activity
AL539_RS19340	COG2198	Histidine kinase
AL539_RS19340	COG0784	Response regulator, receiver
AL539_RS19345	COG1879	ABC-type sugar transport system periplasmic component
AL539_RS19350	COG1803	Methylglyoxal synthase
AL539_RS19355	COG0210	DNA helicase
AL539_RS19360	COG1289	transmembrane transporter activity
AL539_RS19395	COG4771	TonB-dependent receptor
AL539_RS19395	COG1629	transport
AL539_RS19405	COG0789	Transcriptional regulator
AL539_RS19410	COG4604	ABC transporter, ATP-binding protein
AL539_RS19415	COG4605	iron ion homeostasis
AL539_RS19420	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL539_RS19425	COG4607	ABC-type enterochelin transport system periplasmic component
AL539_RS19435	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
AL539_RS19450	COG1609	Transcriptional regulator
AL539_RS19455	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL539_RS19460	COG1879	ABC-type sugar transport system periplasmic component
AL539_RS19465	COG1172	Belongs to the binding-protein-dependent transport system permease family
AL539_RS19470	COG1129	ABC transporter
AL539_RS19475	COG1869	D-ribose catabolic process
AL539_RS19480	COG5001	Diguanylate cyclase
AL539_RS19535	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AL539_RS19545	COG2205	protein histidine kinase activity
AL539_RS19545	COG0784	Response regulator, receiver
AL539_RS19560	COG0330	HflC and HflK could
AL539_RS19575	COG4175	Glycine betaine
AL539_RS19575	COG0517	IMP dehydrogenase activity
AL539_RS19580	COG4176	ABC-type proline glycine betaine transport system permease component
AL539_RS19595	COG1012	belongs to the aldehyde dehydrogenase family
AL539_RS19600	COG1309	transcriptional regulator
AL539_RS19610	COG1028	Short-chain dehydrogenase reductase Sdr
AL539_RS19625	COG1024	Enoyl-CoA hydratase
AL539_RS19630	COG1960	acyl-CoA dehydrogenase activity
AL539_RS19640	COG0183	Belongs to the thiolase family
AL539_RS19650	COG1960	acyl-CoA dehydrogenase activity
AL539_RS19655	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AL539_RS19665	COG4770	biotin carboxylase activity
AL539_RS19680	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AL539_RS19680	COG3264	Mechanosensitive ion channel
AL539_RS19690	COG0110	maltose O-acetyltransferase activity
AL539_RS19695	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL539_RS19700	COG1271	oxidase subunit
AL539_RS19705	COG1294	oxidase, subunit
AL539_RS19720	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AL539_RS19730	COG3527	Alpha-acetolactate decarboxylase
AL539_RS19740	COG1028	Short-chain dehydrogenase reductase Sdr
AL539_RS19745	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL539_RS19775	COG0500	methyltransferase
AL539_RS19805	COG1022	Amp-dependent synthetase and ligase
AL539_RS19835	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AL539_RS19840	COG1263	PTS System
AL539_RS19840	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL539_RS19845	COG1486	melibiose metabolic process
AL539_RS19850	COG2188	Transcriptional regulator
AL539_RS19855	COG1320	monovalent cation:proton antiporter activity
AL539_RS19860	COG2212	antiporter activity
AL539_RS19865	COG1863	multisubunit Na H antiporter MnhE subunit
AL539_RS19870	COG0651	ATP synthesis coupled electron transport
AL539_RS19875	COG1006	Multisubunit Na H antiporter MnhC subunit
AL539_RS19880	COG2111	Na H antiporter
AL539_RS19880	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AL539_RS19890	COG0589	response to stress
AL539_RS19895	COG4221	oxidoreductase activity
AL539_RS19900	COG0583	DNA-binding transcription factor activity
AL539_RS19910	COG2814	Major facilitator Superfamily
AL539_RS19920	COG3179	chitinase
AL539_RS19965	COG1522	sequence-specific DNA binding
AL539_RS20000	COG0515	serine threonine protein kinase
AL539_RS20025	COG3501	Rhs element vgr protein
AL539_RS20065	COG0739	heme binding
AL539_RS20090	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL539_RS20095	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL539_RS20105	COG2207	Transcriptional regulator
AL539_RS20110	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL539_RS20110	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL539_RS20110	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL539_RS20125	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL539_RS20130	COG3537	Alpha-1,2-mannosidase
AL539_RS20135	COG3537	Alpha-1,2-mannosidase
AL539_RS20145	COG3537	Alpha-1,2-mannosidase
AL539_RS20150	COG3537	Alpha-1,2-mannosidase
AL539_RS20180	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AL539_RS20180	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AL539_RS20195	COG4989	oxidoreductase activity
AL539_RS20210	COG0038	chloride channel
AL539_RS20230	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AL539_RS20245	COG2897	thiosulfate sulfurtransferase activity
AL539_RS20265	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AL539_RS20270	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AL539_RS20280	COG2814	Major facilitator Superfamily
AL539_RS20285	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AL539_RS20300	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AL539_RS20310	COG0840	transmembrane signaling receptor activity
AL539_RS20330	COG2195	Cleaves the N-terminal amino acid of tripeptides
AL539_RS20345	COG2197	response regulator
AL539_RS20350	COG3850	Histidine kinase
AL539_RS20355	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AL539_RS20365	COG0243	molybdopterin cofactor binding
AL539_RS20375	COG3005	denitrification pathway
AL539_RS20385	COG3243	poly(R)-hydroxyalkanoic acid synthase
AL539_RS20395	COG0183	Belongs to the thiolase family
AL539_RS20405	COG1280	lysine exporter protein (LysE YggA)
AL539_RS20415	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL539_RS20420	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL539_RS20475	COG1846	Transcriptional regulator
AL539_RS20480	COG0784	Response regulator, receiver
AL539_RS20480	COG2205	protein histidine kinase activity
AL539_RS20485	COG1879	ABC-type sugar transport system periplasmic component
AL539_RS20495	COG2827	Endonuclease containing a URI domain
AL539_RS20500	COG3132	Protein of unknown function, DUF480
AL539_RS20520	COG2205	protein histidine kinase activity
AL539_RS20520	COG5002	protein histidine kinase activity
AL539_RS20520	COG0784	Response regulator, receiver
AL539_RS20560	COG0531	amino acid
AL539_RS20575	COG2205	protein histidine kinase activity
AL539_RS20580	COG0745	RESPONSE REGULATOR receiver
AL539_RS20610	COG1566	PFAM secretion protein HlyD family protein
AL539_RS20615	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AL539_RS20620	COG2239	Acts as a magnesium transporter
AL539_RS20625	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AL539_RS20630	COG0402	S-adenosylhomocysteine deaminase activity
AL539_RS20635	COG1418	mRNA catabolic process
AL539_RS20650	COG2814	Major facilitator Superfamily
AL539_RS20660	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AL539_RS20680	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AL539_RS20695	COG0745	RESPONSE REGULATOR receiver
AL539_RS20700	COG2205	protein histidine kinase activity
AL539_RS20710	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AL539_RS20715	COG2194	sulfuric ester hydrolase activity
AL539_RS20735	COG4667	esterase of the alpha-beta hydrolase superfamily
AL539_RS20740	COG1741	Belongs to the pirin family
AL539_RS20745	COG1278	Cold shock
AL539_RS20760	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AL539_RS20765	COG0678	peroxiredoxin activity
AL539_RS20765	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AL539_RS20775	COG1686	Belongs to the peptidase S11 family
AL539_RS20785	COG0625	glutathione transferase activity
AL539_RS20795	COG1621	beta-fructofuranosidase activity
AL539_RS20800	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL539_RS20805	COG1263	PTS System
AL539_RS20805	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL539_RS20830	COG1028	Short-chain dehydrogenase reductase Sdr
AL539_RS20845	COG3746	phosphate-selective porin O and P
AL539_RS20860	COG1028	Short-chain dehydrogenase reductase Sdr
AL539_RS20865	COG0583	DNA-binding transcription factor activity
AL539_RS20870	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AL539_RS20870	COG2207	Transcriptional regulator
AL539_RS20875	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL539_RS20905	COG0513	Belongs to the DEAD box helicase family
AL539_RS20915	COG0583	DNA-binding transcription factor activity
AL539_RS20930	COG1902	pentaerythritol trinitrate reductase activity
AL539_RS20935	COG1063	alcohol dehydrogenase
AL539_RS20945	COG1028	Short-chain dehydrogenase reductase Sdr
AL539_RS20960	COG0006	proline dipeptidase activity
AL539_RS20965	COG3608	succinylglutamate desuccinylase aspartoacylase
AL539_RS20970	COG1522	sequence-specific DNA binding
AL539_RS20975	COG1012	belongs to the aldehyde dehydrogenase family
AL539_RS20980	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AL539_RS20985	COG3122	Protein conserved in bacteria
AL539_RS21000	COG0583	DNA-binding transcription factor activity
AL539_RS21005	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AL539_RS21010	COG0252	asparaginase activity
AL539_RS21015	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AL539_RS21030	COG2197	response regulator
AL539_RS21035	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AL539_RS21060	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL539_RS21090	COG3842	ATPase activity
AL539_RS21110	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL539_RS21140	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AL539_RS21145	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AL539_RS21180	COG0583	DNA-binding transcription factor activity
AL539_RS21190	COG4948	Mandelate Racemase Muconate Lactonizing
AL539_RS21225	COG1342	Belongs to the UPF0251 family
AL539_RS21235	COG4176	ABC-type proline glycine betaine transport system permease component
AL539_RS21240	COG4175	Glycine betaine
AL539_RS21240	COG3448	diguanylate cyclase activity
AL539_RS21245	COG3015	lipoprotein NlpE involved in copper resistance
AL539_RS21250	COG3713	MltA-interacting MipA family protein
AL539_RS21265	COG0583	DNA-binding transcription factor activity
AL539_RS21290	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AL539_RS21300	COG1335	isochorismatase
AL539_RS21315	COG1349	DNA-binding transcription factor activity
AL539_RS21320	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL539_RS21320	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL539_RS21325	COG2070	2-Nitropropane dioxygenase
AL539_RS21330	COG0531	amino acid
AL539_RS21335	COG4302	ethanolamine ammonia-lyase activity
AL539_RS21340	COG4303	Ethanolamine ammonia lyase large subunit
AL539_RS21350	COG1309	transcriptional regulator
AL539_RS21370	COG1280	lysine exporter protein (LysE YggA)
AL539_RS21380	COG0459	protein refolding
AL539_RS21385	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AL539_RS21390	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AL539_RS21405	COG1304	FMN binding
AL539_RS21430	COG4786	Flagellar basal body rod
AL539_RS21430	COG1256	bacterial-type flagellum assembly
AL539_RS21440	COG1706	bacterial-type flagellum-dependent cell motility
AL539_RS21445	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AL539_RS21450	COG4786	Flagellar basal body rod
AL539_RS21455	COG4787	bacterial-type flagellum-dependent cell motility
AL539_RS21470	COG1558	bacterial-type flagellum-dependent cell motility
AL539_RS21475	COG1815	bacterial-type flagellum-dependent cell motility
AL539_RS21495	COG0741	lytic transglycosylase activity
AL539_RS21500	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AL539_RS21520	COG1760	l-serine dehydratase
AL539_RS21535	COG0583	DNA-binding transcription factor activity
AL539_RS21545	COG2866	Carboxypeptidase
AL539_RS21550	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AL539_RS21560	COG2990	Protein conserved in bacteria
AL539_RS21585	COG3842	ATPase activity
AL539_RS21590	COG1840	ABC-type Fe3 transport system, periplasmic component
AL539_RS21600	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AL539_RS21620	COG3240	lipase activity
AL539_RS21625	COG1309	transcriptional regulator
AL539_RS21640	COG0577	efflux transmembrane transporter activity
AL539_RS21640	COG1136	(ABC) transporter
AL539_RS21660	COG2067	long-chain fatty acid transport protein
AL539_RS21670	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
AL539_RS21685	COG1011	Hydrolase
AL539_RS21725	COG0110	maltose O-acetyltransferase activity
AL539_RS21730	COG1765	OsmC-like protein
AL539_RS21735	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL539_RS21735	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL539_RS21750	COG3046	protein related to deoxyribodipyrimidine photolyase
AL539_RS21755	COG0415	Belongs to the DNA photolyase family
AL539_RS21760	COG3706	GGDEF domain
AL539_RS21790	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AL539_RS21810	COG3033	Beta-eliminating lyase
AL539_RS21820	COG1271	oxidase subunit
AL539_RS21825	COG1294	oxidase, subunit
AL539_RS21840	COG0579	oxidoreductase
AL539_RS21865	COG3706	GGDEF domain
AL539_RS21895	COG0583	DNA-binding transcription factor activity
AL539_RS21920	COG0189	ligase activity
AL539_RS21925	COG0189	ligase activity
AL539_RS21925	COG4067	protein conserved in archaea
AL539_RS21935	COG1166	arginine decarboxylase activity
AL539_RS21940	COG0010	Belongs to the arginase family
AL539_RS21945	COG2814	Major facilitator Superfamily
AL539_RS21950	COG1770	oligopeptidase
AL539_RS21965	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AL539_RS21970	COG1121	(ABC) transporter
AL539_RS21975	COG0803	Belongs to the bacterial solute-binding protein 9 family
AL539_RS22015	COG0848	biopolymer transport protein
AL539_RS22020	COG0811	peptide transport
AL539_RS22025	COG0811	peptide transport
AL539_RS22045	COG0745	RESPONSE REGULATOR receiver
AL539_RS22050	COG0584	glycerophosphoryl diester phosphodiesterase
AL539_RS22060	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AL539_RS22120	COG1901	pseudouridine methyltransferase
AL539_RS22125	COG0312	modulator of DNA gyrase
AL539_RS22130	COG0312	modulator of DNA gyrase
AL539_RS22135	COG0351	phosphomethylpyrimidine kinase
AL539_RS22140	COG1116	anion transmembrane transporter activity
AL539_RS22145	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AL539_RS22150	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AL539_RS22155	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AL539_RS22175	COG0243	molybdopterin cofactor binding
AL539_RS22180	COG3005	denitrification pathway
AL539_RS22185	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL539_RS22190	COG1028	Short-chain dehydrogenase reductase Sdr
AL539_RS22205	COG0456	acetyltransferase
AL539_RS22225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL539_RS22230	COG1929	Belongs to the glycerate kinase type-1 family
AL539_RS22235	COG2610	gluconate transmembrane transporter activity
AL539_RS22240	COG3835	regulator
AL539_RS22300	COG3047	cAMP biosynthetic process
AL539_RS22305	COG1357	PFAM Pentapeptide repeats (8 copies)
AL539_RS22335	COG2375	cellular response to nickel ion
AL539_RS22340	COG0583	DNA-binding transcription factor activity
AL539_RS22345	COG2162	N-hydroxyarylamine O-acetyltransferase activity
AL539_RS22350	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AL539_RS22365	COG2199	diguanylate cyclase activity
AL539_RS22375	COG0561	phosphatase activity
AL539_RS22380	COG0583	DNA-binding transcription factor activity
AL539_RS22395	COG0564	pseudouridine synthase activity
AL539_RS22400	COG0534	Mate efflux family protein
AL539_RS22405	COG5001	Diguanylate cyclase
AL539_RS22415	COG3123	guanosine phosphorylase activity
AL539_RS22440	COG0596	Alpha beta hydrolase
AL539_RS22465	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AL539_RS22475	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AL539_RS22480	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AL539_RS22480	COG2169	Transcriptional regulator
AL539_RS22490	COG2259	Doxx family
AL539_RS22495	COG1741	Belongs to the pirin family
AL539_RS22515	COG0363	glucosamine-6-phosphate deaminase activity
AL539_RS22525	COG0786	glutamate:sodium symporter activity
AL539_RS22530	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL539_RS22535	COG1131	(ABC) transporter
AL539_RS22545	COG0786	glutamate:sodium symporter activity
AL539_RS22570	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AL539_RS22580	COG3279	Response regulator of the LytR AlgR family
AL539_RS22585	COG3275	phosphorelay sensor kinase activity
AL539_RS22615	COG0772	Belongs to the SEDS family
AL539_RS22640	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AL539_RS22640	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
AL539_RS22650	COG0444	Belongs to the ABC transporter superfamily
AL539_RS22655	COG4608	Belongs to the ABC transporter superfamily
AL539_RS22680	COG1444	tRNA N-acetyltransferase activity
AL539_RS22705	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AL539_RS22710	COG1263	PTS System
AL539_RS22710	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL539_RS22715	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AL539_RS22735	COG4166	transmembrane transport
AL539_RS22785	COG0259	pyridoxamine-phosphate oxidase activity
AL539_RS22810	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AL539_RS22850	COG1132	(ABC) transporter
AL539_RS22860	COG0513	Belongs to the DEAD box helicase family
AL539_RS22865	COG2258	MOSC domain
AL539_RS22920	COG3634	alkyl hydroperoxide reductase activity
AL539_RS22930	COG1846	Transcriptional regulator
AL539_RS22935	COG1764	response to oxidative stress
AL539_RS22980	COG0577	efflux transmembrane transporter activity
AL539_RS22985	COG1136	(ABC) transporter
AL539_RS22995	COG0826	peptidase U32
AL539_RS23005	COG0019	diaminopimelate decarboxylase activity
AL539_RS23010	COG4264	IucA IucC family
AL539_RS23035	COG4772	TonB-dependent receptor
AL539_RS23040	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
AL539_RS23045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL539_RS23050	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL539_RS23055	COG1120	ATPase activity
AL539_RS23060	COG0840	transmembrane signaling receptor activity
AL539_RS23065	COG0612	Peptidase, M16
AL539_RS23075	COG0739	heme binding
AL539_RS23090	COG2814	Major facilitator Superfamily
AL539_RS23100	COG1609	Transcriptional regulator
AL539_RS23105	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AL539_RS23120	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AL539_RS23120	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AL539_RS23130	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AL539_RS23135	COG1609	Transcriptional regulator
AL539_RS23145	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AL539_RS23185	COG1760	l-serine dehydratase
AL539_RS23195	COG4580	involved in the transport of maltose and maltodextrins
AL539_RS23215	COG2356	endonuclease I
AL539_RS23235	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
AL539_RS23240	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
AL539_RS23245	COG1162	GTPase activity
AL539_RS23250	COG1263	PTS System
AL539_RS23250	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL539_RS23255	COG1999	signal sequence binding
AL539_RS23270	COG2909	trisaccharide binding
AL539_RS23275	COG0058	SHG alpha-glucan phosphorylase activity
AL539_RS23280	COG1640	4-alpha-glucanotransferase
AL539_RS23285	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AL539_RS23290	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AL539_RS23295	COG0366	Alpha amylase catalytic
AL539_RS23310	COG3366	ferrous iron transmembrane transporter activity
AL539_RS23315	COG0700	Nucleoside recognition
AL539_RS23320	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AL539_RS23325	COG3339	Conserved Protein
AL539_RS23340	COG1301	dicarboxylic acid transport
AL539_RS23350	COG0583	DNA-binding transcription factor activity
AL539_RS23395	COG2095	MarC family integral membrane protein
AL539_RS23400	COG4667	esterase of the alpha-beta hydrolase superfamily
AL539_RS23405	COG3397	chitin binding
AL539_RS23410	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
AL539_RS23415	COG0415	Belongs to the DNA photolyase family
AL539_RS23425	COG1054	Belongs to the UPF0176 family
AL539_RS23435	COG1686	Belongs to the peptidase S11 family
AL539_RS23460	COG0583	DNA-binding transcription factor activity
AL539_RS23465	COG4628	conserved protein (DUF2132)
AL539_RS23485	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
AL539_RS23490	COG0628	permease
AL539_RS23535	COG2814	Major facilitator Superfamily
AL539_RS23545	COG0454	-acetyltransferase
AL539_RS23555	COG0745	RESPONSE REGULATOR receiver
AL539_RS23560	COG2205	protein histidine kinase activity
AL539_RS23575	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AL539_RS23580	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AL539_RS23585	COG1882	Formate acetyltransferase
AL539_RS23620	COG1360	Flagellar Motor Protein
AL539_RS23625	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AL539_RS23630	COG1191	sigma factor activity
AL539_RS23635	COG1580	Controls the rotational direction of flagella during chemotaxis
AL539_RS23650	COG1516	flagellar protein fliS
AL539_RS23655	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AL539_RS23665	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL539_RS23680	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AL539_RS23690	COG1987	bacterial-type flagellum assembly
AL539_RS23730	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AL539_RS23790	COG0346	lactoylglutathione lyase activity
AL539_RS23815	COG0745	RESPONSE REGULATOR receiver
AL539_RS23840	COG5001	Diguanylate cyclase
AL539_RS23840	COG3300	MHYT domain
AL539_RS23845	COG0156	8-amino-7-oxononanoate synthase activity
AL539_RS23850	COG1063	alcohol dehydrogenase
AL539_RS23885	COG0668	transmembrane transport
AL539_RS23895	COG1304	FMN binding
AL539_RS23900	COG1620	l-lactate permease
AL539_RS23905	COG0583	DNA-binding transcription factor activity
AL539_RS23910	COG1505	serine-type exopeptidase activity
AL539_RS23915	COG4172	Belongs to the ABC transporter superfamily
AL539_RS23925	COG1067	ATP-dependent peptidase activity
AL539_RS23930	COG0840	transmembrane signaling receptor activity
AL539_RS23935	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AL539_RS23955	COG1247	-acetyltransferase
AL539_RS23960	COG0437	4 iron, 4 sulfur cluster binding
AL539_RS23965	COG0348	domain, Protein
AL539_RS23985	COG1122	ATPase activity
AL539_RS23990	COG4720	Psort location CytoplasmicMembrane, score
AL539_RS23995	COG1566	PFAM secretion protein HlyD family protein
AL539_RS24020	COG0813	purine-nucleoside phosphorylase activity
AL539_RS24025	COG3272	Protein of unknown function (DUF1722)
AL539_RS24030	COG0789	Transcriptional regulator
AL539_RS24035	COG0415	Belongs to the DNA photolyase family
AL539_RS24040	COG1376	ErfK ybiS ycfS ynhG family protein
AL539_RS24040	COG1388	LysM domain
AL539_RS24050	COG0513	Belongs to the DEAD box helicase family
AL539_RS24055	COG1770	oligopeptidase
AL539_RS24060	COG4771	TonB-dependent receptor
AL539_RS24090	COG0573	inorganic phosphate transmembrane transporter activity
AL539_RS24095	COG0581	inorganic phosphate transmembrane transporter activity
AL539_RS24100	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AL539_RS24115	COG2304	oxidoreductase activity
AL539_RS24120	COG2304	oxidoreductase activity
AL539_RS24135	COG0714	Associated with various cellular activities
AL539_RS24150	COG2197	response regulator
AL539_RS24185	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
AL539_RS24190	COG1120	ATPase activity
AL539_RS24200	COG1132	(ABC) transporter
AL539_RS24205	COG2205	protein histidine kinase activity
AL539_RS24215	COG0569	domain protein
AL539_RS24220	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AL539_RS24225	COG0583	DNA-binding transcription factor activity
AL539_RS24240	COG1012	belongs to the aldehyde dehydrogenase family
AL539_RS24245	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AL539_RS24250	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AL539_RS24260	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
AL539_RS24265	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AL539_RS24295	COG2084	Dehydrogenase
AL539_RS24300	COG0753	catalase activity
AL539_RS24310	COG2130	NADP-dependent
AL539_RS24315	COG1309	transcriptional regulator
AL539_RS24320	COG3097	Belongs to the UPF0267 family
AL539_RS24360	COG0489	protein tyrosine kinase activity
AL539_RS24360	COG3206	protein involved in exopolysaccharide biosynthesis
AL539_RS24375	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AL539_RS24380	COG3842	ATPase activity
AL539_RS24390	COG1175	transmembrane transport
AL539_RS24395	COG3833	ABC-type maltose transport systems, permease component
AL539_RS24425	COG2375	cellular response to nickel ion
AL539_RS24425	COG1132	(ABC) transporter
AL539_RS24430	COG4774	siderophore transport
AL539_RS24435	COG4607	ABC-type enterochelin transport system periplasmic component
AL539_RS24440	COG4605	iron ion homeostasis
AL539_RS24445	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL539_RS24455	COG2354	Protein conserved in bacteria
AL539_RS24460	COG0418	dihydroorotase activity
AL539_RS24470	COG0401	homolog of Blt101
AL539_RS24475	COG0633	Ferredoxin
AL539_RS24475	COG3217	Mosc domain protein beta barrel domain protein
AL539_RS24475	COG3217	Mosc domain protein beta barrel domain protein
AL539_RS24475	COG0633	Ferredoxin
AL539_RS24485	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AL539_RS24525	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AL539_RS24530	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL539_RS24540	COG0848	biopolymer transport protein
AL539_RS24545	COG0811	peptide transport
AL539_RS24550	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
AL539_RS24560	COG3721	Heme iron utilization protein
AL539_RS24565	COG0748	coenzyme F420 binding
AL539_RS24575	COG0784	Response regulator, receiver
AL539_RS24575	COG0835	chemotaxis
AL539_RS24580	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AL539_RS24585	COG0534	Mate efflux family protein
AL539_RS24590	COG0444	Belongs to the ABC transporter superfamily
AL539_RS24595	COG4608	Belongs to the ABC transporter superfamily
AL539_RS24600	COG0747	negative chemotaxis
AL539_RS24610	COG1349	DNA-binding transcription factor activity
AL539_RS24615	COG2084	Dehydrogenase
AL539_RS24620	COG3395	kinase activity
AL539_RS24625	COG0235	Class ii aldolase
AL539_RS24630	COG3622	Belongs to the hyi family
AL539_RS24635	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AL539_RS24640	COG2610	gluconate transmembrane transporter activity
AL539_RS24665	COG0583	DNA-binding transcription factor activity
AL539_RS24670	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AL539_RS24680	COG4934	collagen metabolic process
AL539_RS24690	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AL539_RS24695	COG0789	Transcriptional regulator
AL539_RS24700	COG0366	Alpha amylase catalytic
AL539_RS24720	COG2249	NAD(P)H dehydrogenase (quinone) activity
AL539_RS24725	COG0589	response to stress
AL539_RS24730	COG0488	(ABC) transporter
AL539_RS24735	COG1505	serine-type exopeptidase activity
AL539_RS24745	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL539_RS24755	COG2067	long-chain fatty acid transport protein
AL539_RS24765	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL539_RS24790	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL539_RS24810	COG3383	formate dehydrogenase (NAD+) activity
AL539_RS24820	COG0842	Transport permease protein
AL539_RS24825	COG1131	(ABC) transporter
AL539_RS24840	COG1881	PFAM PEBP family protein
AL539_RS24850	COG0798	PFAM Bile acid sodium symporter
AL539_RS24865	COG1733	regulation of RNA biosynthetic process
AL539_RS24895	COG4989	oxidoreductase activity
AL539_RS24920	COG0814	amino acid
AL539_RS24935	COG3314	Sporulation integral membrane protein YlbJ
AL539_RS24960	COG0739	heme binding
AL539_RS24965	COG5001	Diguanylate cyclase
AL539_RS24970	COG0583	DNA-binding transcription factor activity
AL539_RS24975	COG2814	Major facilitator Superfamily
AL539_RS24995	COG0697	spore germination
AL539_RS25010	COG0179	Fumarylacetoacetate (FAA) hydrolase
AL539_RS25030	COG1280	lysine exporter protein (LysE YggA)
AL539_RS25040	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AL539_RS25045	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AL539_RS25050	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AL539_RS25055	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
AL539_RS25060	COG1845	cytochrome c oxidase, subunit III
AL539_RS25080	COG1612	heme a metabolic process
AL539_RS25090	COG0545	Peptidyl-prolyl cis-trans isomerase
AL539_RS25120	COG1278	Cold shock
AL539_RS25125	COG3036	rescue of stalled ribosome
AL539_RS25130	COG2199	diguanylate cyclase activity
AL539_RS25145	COG1132	(ABC) transporter
AL539_RS25155	COG1538	Outer membrane efflux protein
AL539_RS25160	COG2205	protein histidine kinase activity
AL539_RS25160	COG0784	Response regulator, receiver
AL539_RS25185	COG0840	transmembrane signaling receptor activity
AL539_RS25190	COG0783	Belongs to the Dps family
AL539_RS25200	COG2133	pyrroloquinoline quinone binding
AL539_RS25205	COG1454	alcohol dehydrogenase
AL539_RS25210	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
AL539_RS25230	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AL539_RS25235	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AL539_RS25240	COG3186	Phenylalanine-4-hydroxylase
AL539_RS25265	COG3530	Putative quorum-sensing-regulated virulence factor
AL539_RS25305	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
AL539_RS25320	COG0732	type I restriction modification DNA specificity domain
AL539_RS25325	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AL539_RS25365	COG0393	Putative heavy-metal-binding
AL539_RS25445	COG4628	conserved protein (DUF2132)
AL539_RS25455	COG0133	tryptophan synthase activity
AL539_RS25465	COG1278	Cold shock
AL539_RS25475	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
AL539_RS25485	COG0523	cobalamin synthesis protein
AL539_RS25490	COG0513	Belongs to the DEAD box helicase family
AL539_RS25510	COG2200	EAL domain
AL539_RS25515	COG1119	ATPase activity
AL539_RS25550	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
AL539_RS25555	COG0513	Belongs to the DEAD box helicase family
AL539_RS25570	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AL539_RS25580	COG1073	alpha beta
AL539_RS25585	COG1073	alpha beta
AL539_RS25600	COG0730	response to heat
AL539_RS25615	COG0735	belongs to the Fur family
AL539_RS25620	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AL539_RS25630	COG0523	cobalamin synthesis protein
AL539_RS25635	COG2988	succinylglutamate desuccinylase activity
AL539_RS25640	COG0739	heme binding
AL539_RS25650	COG0523	cobalamin synthesis protein
AL539_RS25670	COG2095	MarC family integral membrane protein
AL539_RS25700	COG1024	Enoyl-CoA hydratase
AL539_RS25705	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AL539_RS25710	COG1960	acyl-CoA dehydrogenase activity
AL539_RS25720	COG0183	Belongs to the thiolase family
AL539_RS25735	COG1024	Enoyl-CoA hydratase
AL539_RS25740	COG1024	Enoyl-CoA hydratase
AL539_RS25750	COG1028	Short-chain dehydrogenase reductase Sdr
AL539_RS25755	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AL539_RS25760	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AL539_RS25765	COG1845	cytochrome c oxidase, subunit III
AL539_RS25770	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AL539_RS25775	COG0109	protoheme IX farnesyltransferase activity
AL539_RS25780	COG0446	pyridine nucleotide-disulphide oxidoreductase
AL539_RS25780	COG1902	pentaerythritol trinitrate reductase activity
AL539_RS25795	COG1012	belongs to the aldehyde dehydrogenase family
AL539_RS25805	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL539_RS25835	COG1126	abc transporter atp-binding protein
AL539_RS25840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL539_RS25845	COG4215	(ABC) transporter
AL539_RS25850	COG4160	amino acid transport
AL539_RS25915	COG0443	Heat shock 70 kDa protein
AL539_RS25920	COG2847	Copper chaperone PCu(A)C
AL539_RS25995	COG0814	amino acid
AL539_RS26005	COG0243	molybdopterin cofactor binding
AL539_RS26035	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AL539_RS26035	COG1116	anion transmembrane transporter activity
AL539_RS26050	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AL539_RS26055	COG1116	anion transmembrane transporter activity
AL539_RS26060	COG2146	nitrite reductase [NAD(P)H] activity
AL539_RS26060	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AL539_RS26110	COG2815	serine threonine protein kinase
AL539_RS26110	COG0515	serine threonine protein kinase