locus-tag	class	description
AL545_RS00005	COG0583	DNA-binding transcription factor activity
AL545_RS00030	COG0189	ligase activity
AL545_RS00035	COG4067	protein conserved in archaea
AL545_RS00035	COG0189	ligase activity
AL545_RS00045	COG1166	arginine decarboxylase activity
AL545_RS00050	COG0010	Belongs to the arginase family
AL545_RS00055	COG2814	Major facilitator Superfamily
AL545_RS00060	COG1770	oligopeptidase
AL545_RS00075	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AL545_RS00080	COG1121	(ABC) transporter
AL545_RS00085	COG0803	Belongs to the bacterial solute-binding protein 9 family
AL545_RS00125	COG0848	biopolymer transport protein
AL545_RS00130	COG0811	peptide transport
AL545_RS00135	COG0811	peptide transport
AL545_RS00155	COG0745	RESPONSE REGULATOR receiver
AL545_RS00160	COG0584	glycerophosphoryl diester phosphodiesterase
AL545_RS00170	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AL545_RS00235	COG1901	pseudouridine methyltransferase
AL545_RS00240	COG0312	modulator of DNA gyrase
AL545_RS00245	COG0312	modulator of DNA gyrase
AL545_RS00250	COG0351	phosphomethylpyrimidine kinase
AL545_RS00255	COG1116	anion transmembrane transporter activity
AL545_RS00260	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AL545_RS00265	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AL545_RS00270	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AL545_RS00275	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
AL545_RS00280	COG0352	thiamine-phosphate diphosphorylase activity
AL545_RS00290	COG0243	molybdopterin cofactor binding
AL545_RS00295	COG3005	denitrification pathway
AL545_RS00300	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL545_RS00305	COG1028	Short-chain dehydrogenase reductase Sdr
AL545_RS00320	COG0456	acetyltransferase
AL545_RS00340	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL545_RS00345	COG1929	Belongs to the glycerate kinase type-1 family
AL545_RS00350	COG2610	gluconate transmembrane transporter activity
AL545_RS00355	COG3835	regulator
AL545_RS00415	COG3047	cAMP biosynthetic process
AL545_RS00420	COG1357	PFAM Pentapeptide repeats (8 copies)
AL545_RS00450	COG2375	cellular response to nickel ion
AL545_RS00455	COG0583	DNA-binding transcription factor activity
AL545_RS00460	COG2162	N-hydroxyarylamine O-acetyltransferase activity
AL545_RS00465	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AL545_RS00480	COG2199	diguanylate cyclase activity
AL545_RS00490	COG0561	phosphatase activity
AL545_RS00495	COG0583	DNA-binding transcription factor activity
AL545_RS00510	COG0564	pseudouridine synthase activity
AL545_RS00515	COG0534	Mate efflux family protein
AL545_RS00530	COG3123	guanosine phosphorylase activity
AL545_RS00545	COG0596	Alpha beta hydrolase
AL545_RS00570	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AL545_RS00580	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AL545_RS00585	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AL545_RS00585	COG2169	Transcriptional regulator
AL545_RS00595	COG2259	Doxx family
AL545_RS00600	COG1741	Belongs to the pirin family
AL545_RS00620	COG0363	glucosamine-6-phosphate deaminase activity
AL545_RS00630	COG0786	glutamate:sodium symporter activity
AL545_RS00640	COG1131	(ABC) transporter
AL545_RS00650	COG0786	glutamate:sodium symporter activity
AL545_RS00675	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AL545_RS00680	COG3279	Response regulator of the LytR AlgR family
AL545_RS00685	COG3275	phosphorelay sensor kinase activity
AL545_RS00705	COG1136	(ABC) transporter
AL545_RS00715	COG0772	Belongs to the SEDS family
AL545_RS00740	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
AL545_RS00740	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AL545_RS00750	COG0444	Belongs to the ABC transporter superfamily
AL545_RS00755	COG4608	Belongs to the ABC transporter superfamily
AL545_RS00780	COG1444	tRNA N-acetyltransferase activity
AL545_RS00800	COG3340	Belongs to the peptidase S51 family
AL545_RS00805	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AL545_RS00810	COG1263	PTS System
AL545_RS00810	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL545_RS00815	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AL545_RS00835	COG4166	transmembrane transport
AL545_RS00890	COG0259	pyridoxamine-phosphate oxidase activity
AL545_RS00915	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AL545_RS00955	COG1132	(ABC) transporter
AL545_RS00965	COG0513	Belongs to the DEAD box helicase family
AL545_RS00970	COG2258	MOSC domain
AL545_RS01030	COG3634	alkyl hydroperoxide reductase activity
AL545_RS01040	COG1846	Transcriptional regulator
AL545_RS01045	COG1764	response to oxidative stress
AL545_RS01075	COG0577	efflux transmembrane transporter activity
AL545_RS01080	COG1136	(ABC) transporter
AL545_RS01090	COG0826	peptidase U32
AL545_RS01100	COG0019	diaminopimelate decarboxylase activity
AL545_RS01105	COG4264	IucA IucC family
AL545_RS01130	COG4772	TonB-dependent receptor
AL545_RS01135	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
AL545_RS01140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL545_RS01145	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL545_RS01150	COG1120	ATPase activity
AL545_RS01155	COG0840	transmembrane signaling receptor activity
AL545_RS01160	COG0612	Peptidase, M16
AL545_RS01170	COG0739	heme binding
AL545_RS01185	COG2814	Major facilitator Superfamily
AL545_RS01195	COG1609	Transcriptional regulator
AL545_RS01200	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AL545_RS01215	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AL545_RS01215	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AL545_RS01225	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AL545_RS01230	COG1609	Transcriptional regulator
AL545_RS01240	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AL545_RS01280	COG1760	l-serine dehydratase
AL545_RS01290	COG4580	involved in the transport of maltose and maltodextrins
AL545_RS01310	COG2356	endonuclease I
AL545_RS01330	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
AL545_RS01335	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
AL545_RS01340	COG1162	GTPase activity
AL545_RS01345	COG1263	PTS System
AL545_RS01345	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL545_RS01350	COG1999	signal sequence binding
AL545_RS01365	COG2909	trisaccharide binding
AL545_RS01370	COG0058	SHG alpha-glucan phosphorylase activity
AL545_RS01375	COG1640	4-alpha-glucanotransferase
AL545_RS01380	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AL545_RS01385	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AL545_RS01390	COG0366	Alpha amylase catalytic
AL545_RS01405	COG3366	ferrous iron transmembrane transporter activity
AL545_RS01410	COG0700	Nucleoside recognition
AL545_RS01415	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AL545_RS01420	COG3339	Conserved Protein
AL545_RS01425	COG1301	dicarboxylic acid transport
AL545_RS01435	COG0583	DNA-binding transcription factor activity
AL545_RS01455	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AL545_RS01460	COG1596	polysaccharide export
AL545_RS01475	COG2095	MarC family integral membrane protein
AL545_RS01480	COG4667	esterase of the alpha-beta hydrolase superfamily
AL545_RS01485	COG3397	chitin binding
AL545_RS01490	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
AL545_RS01495	COG0415	Belongs to the DNA photolyase family
AL545_RS01505	COG1054	Belongs to the UPF0176 family
AL545_RS01515	COG1686	Belongs to the peptidase S11 family
AL545_RS01540	COG0583	DNA-binding transcription factor activity
AL545_RS01545	COG4628	conserved protein (DUF2132)
AL545_RS01565	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
AL545_RS01570	COG0628	permease
AL545_RS01615	COG2814	Major facilitator Superfamily
AL545_RS01625	COG0454	-acetyltransferase
AL545_RS01635	COG0745	RESPONSE REGULATOR receiver
AL545_RS01640	COG2205	protein histidine kinase activity
AL545_RS01655	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AL545_RS01660	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AL545_RS01665	COG1882	Formate acetyltransferase
AL545_RS01700	COG1360	Flagellar Motor Protein
AL545_RS01705	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AL545_RS01710	COG1191	sigma factor activity
AL545_RS01715	COG1580	Controls the rotational direction of flagella during chemotaxis
AL545_RS01730	COG1516	flagellar protein fliS
AL545_RS01735	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AL545_RS01745	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL545_RS01760	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AL545_RS01770	COG1987	bacterial-type flagellum assembly
AL545_RS01810	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AL545_RS01870	COG0346	lactoylglutathione lyase activity
AL545_RS01895	COG0745	RESPONSE REGULATOR receiver
AL545_RS01920	COG3300	MHYT domain
AL545_RS01920	COG5001	Diguanylate cyclase
AL545_RS01925	COG0156	8-amino-7-oxononanoate synthase activity
AL545_RS01930	COG1063	alcohol dehydrogenase
AL545_RS01965	COG0668	transmembrane transport
AL545_RS01975	COG1304	FMN binding
AL545_RS01980	COG1620	l-lactate permease
AL545_RS01985	COG0583	DNA-binding transcription factor activity
AL545_RS01990	COG1505	serine-type exopeptidase activity
AL545_RS01995	COG4172	Belongs to the ABC transporter superfamily
AL545_RS02005	COG1067	ATP-dependent peptidase activity
AL545_RS02015	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AL545_RS02035	COG1247	-acetyltransferase
AL545_RS02040	COG0437	4 iron, 4 sulfur cluster binding
AL545_RS02045	COG0348	domain, Protein
AL545_RS02065	COG1122	ATPase activity
AL545_RS02070	COG4720	Psort location CytoplasmicMembrane, score
AL545_RS02075	COG1566	PFAM secretion protein HlyD family protein
AL545_RS02100	COG0813	purine-nucleoside phosphorylase activity
AL545_RS02105	COG3272	Protein of unknown function (DUF1722)
AL545_RS02110	COG0789	Transcriptional regulator
AL545_RS02115	COG0415	Belongs to the DNA photolyase family
AL545_RS02120	COG1376	ErfK ybiS ycfS ynhG family protein
AL545_RS02120	COG1388	LysM domain
AL545_RS02130	COG0513	Belongs to the DEAD box helicase family
AL545_RS02135	COG1770	oligopeptidase
AL545_RS02140	COG4771	TonB-dependent receptor
AL545_RS02170	COG0573	inorganic phosphate transmembrane transporter activity
AL545_RS02175	COG0581	inorganic phosphate transmembrane transporter activity
AL545_RS02180	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AL545_RS02195	COG2304	oxidoreductase activity
AL545_RS02215	COG0714	Associated with various cellular activities
AL545_RS02230	COG2197	response regulator
AL545_RS02265	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
AL545_RS02270	COG1120	ATPase activity
AL545_RS02275	COG4774	siderophore transport
AL545_RS02280	COG1132	(ABC) transporter
AL545_RS02285	COG2205	protein histidine kinase activity
AL545_RS02295	COG0569	domain protein
AL545_RS02300	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AL545_RS02305	COG0583	DNA-binding transcription factor activity
AL545_RS02325	COG1012	belongs to the aldehyde dehydrogenase family
AL545_RS02330	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AL545_RS02335	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AL545_RS02345	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
AL545_RS02350	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AL545_RS02380	COG2084	Dehydrogenase
AL545_RS02385	COG0753	catalase activity
AL545_RS02395	COG2130	NADP-dependent
AL545_RS02400	COG1309	transcriptional regulator
AL545_RS02405	COG3097	Belongs to the UPF0267 family
AL545_RS02445	COG0489	protein tyrosine kinase activity
AL545_RS02445	COG3206	protein involved in exopolysaccharide biosynthesis
AL545_RS02460	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AL545_RS02465	COG3842	ATPase activity
AL545_RS02475	COG1175	transmembrane transport
AL545_RS02480	COG3833	ABC-type maltose transport systems, permease component
AL545_RS02510	COG2375	cellular response to nickel ion
AL545_RS02510	COG1132	(ABC) transporter
AL545_RS02515	COG4774	siderophore transport
AL545_RS02520	COG4607	ABC-type enterochelin transport system periplasmic component
AL545_RS02525	COG4605	iron ion homeostasis
AL545_RS02530	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL545_RS02540	COG2354	Protein conserved in bacteria
AL545_RS02545	COG0418	dihydroorotase activity
AL545_RS02555	COG0401	homolog of Blt101
AL545_RS02560	COG0633	Ferredoxin
AL545_RS02560	COG3217	Mosc domain protein beta barrel domain protein
AL545_RS02560	COG3217	Mosc domain protein beta barrel domain protein
AL545_RS02560	COG0633	Ferredoxin
AL545_RS02570	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AL545_RS02610	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AL545_RS02615	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL545_RS02625	COG0848	biopolymer transport protein
AL545_RS02630	COG0811	peptide transport
AL545_RS02635	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
AL545_RS02645	COG3721	Heme iron utilization protein
AL545_RS02650	COG0748	coenzyme F420 binding
AL545_RS02660	COG0784	Response regulator, receiver
AL545_RS02660	COG0835	chemotaxis
AL545_RS02665	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AL545_RS02670	COG0534	Mate efflux family protein
AL545_RS02675	COG0444	Belongs to the ABC transporter superfamily
AL545_RS02680	COG4608	Belongs to the ABC transporter superfamily
AL545_RS02685	COG0747	negative chemotaxis
AL545_RS02695	COG1349	DNA-binding transcription factor activity
AL545_RS02700	COG2084	Dehydrogenase
AL545_RS02705	COG3395	kinase activity
AL545_RS02710	COG0235	Class ii aldolase
AL545_RS02715	COG3622	Belongs to the hyi family
AL545_RS02720	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AL545_RS02725	COG2610	gluconate transmembrane transporter activity
AL545_RS02750	COG0583	DNA-binding transcription factor activity
AL545_RS02755	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AL545_RS02765	COG4934	collagen metabolic process
AL545_RS02775	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AL545_RS02780	COG0789	Transcriptional regulator
AL545_RS02785	COG0366	Alpha amylase catalytic
AL545_RS02810	COG2249	NAD(P)H dehydrogenase (quinone) activity
AL545_RS02815	COG0589	response to stress
AL545_RS02820	COG0488	(ABC) transporter
AL545_RS02825	COG1505	serine-type exopeptidase activity
AL545_RS02835	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL545_RS02845	COG2067	long-chain fatty acid transport protein
AL545_RS02855	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL545_RS02880	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL545_RS02900	COG3383	formate dehydrogenase (NAD+) activity
AL545_RS02910	COG0842	Transport permease protein
AL545_RS02915	COG1131	(ABC) transporter
AL545_RS02930	COG1881	PFAM PEBP family protein
AL545_RS02940	COG0798	PFAM Bile acid sodium symporter
AL545_RS02960	COG1733	regulation of RNA biosynthetic process
AL545_RS02985	COG4989	oxidoreductase activity
AL545_RS03010	COG0814	amino acid
AL545_RS03025	COG3314	Sporulation integral membrane protein YlbJ
AL545_RS03050	COG0739	heme binding
AL545_RS03055	COG5001	Diguanylate cyclase
AL545_RS03060	COG0583	DNA-binding transcription factor activity
AL545_RS03065	COG2814	Major facilitator Superfamily
AL545_RS03085	COG0697	spore germination
AL545_RS03100	COG0179	Fumarylacetoacetate (FAA) hydrolase
AL545_RS03120	COG1280	lysine exporter protein (LysE YggA)
AL545_RS03130	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AL545_RS03135	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AL545_RS03140	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AL545_RS03145	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
AL545_RS03150	COG1845	cytochrome c oxidase, subunit III
AL545_RS03170	COG1612	heme a metabolic process
AL545_RS03175	COG0109	protoheme IX farnesyltransferase activity
AL545_RS03180	COG0545	Peptidyl-prolyl cis-trans isomerase
AL545_RS03210	COG1278	Cold shock
AL545_RS03215	COG3036	rescue of stalled ribosome
AL545_RS03220	COG2199	diguanylate cyclase activity
AL545_RS03245	COG1538	Outer membrane efflux protein
AL545_RS03250	COG2205	protein histidine kinase activity
AL545_RS03250	COG0784	Response regulator, receiver
AL545_RS03275	COG0840	transmembrane signaling receptor activity
AL545_RS03280	COG0783	Belongs to the Dps family
AL545_RS03295	COG2133	pyrroloquinoline quinone binding
AL545_RS03300	COG1454	alcohol dehydrogenase
AL545_RS03305	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
AL545_RS03325	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AL545_RS03330	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AL545_RS03335	COG3186	Phenylalanine-4-hydroxylase
AL545_RS03360	COG3530	Putative quorum-sensing-regulated virulence factor
AL545_RS03380	COG0513	Belongs to the DEAD box helicase family
AL545_RS03385	COG4628	conserved protein (DUF2132)
AL545_RS03395	COG0133	tryptophan synthase activity
AL545_RS03405	COG1278	Cold shock
AL545_RS03415	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
AL545_RS03425	COG0523	cobalamin synthesis protein
AL545_RS03430	COG0513	Belongs to the DEAD box helicase family
AL545_RS03450	COG2200	EAL domain
AL545_RS03455	COG1119	ATPase activity
AL545_RS03490	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
AL545_RS03495	COG0513	Belongs to the DEAD box helicase family
AL545_RS03510	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AL545_RS03520	COG1073	alpha beta
AL545_RS03525	COG1073	alpha beta
AL545_RS03540	COG0730	response to heat
AL545_RS03555	COG0735	belongs to the Fur family
AL545_RS03560	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AL545_RS03570	COG0523	cobalamin synthesis protein
AL545_RS03575	COG2988	succinylglutamate desuccinylase activity
AL545_RS03580	COG0739	heme binding
AL545_RS03590	COG0523	cobalamin synthesis protein
AL545_RS03610	COG2095	MarC family integral membrane protein
AL545_RS03670	COG0277	FAD linked oxidase domain protein
AL545_RS03670	COG0247	lactate metabolic process
AL545_RS03685	COG1024	Enoyl-CoA hydratase
AL545_RS03690	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AL545_RS03695	COG1960	acyl-CoA dehydrogenase activity
AL545_RS03705	COG0183	Belongs to the thiolase family
AL545_RS03720	COG1024	Enoyl-CoA hydratase
AL545_RS03725	COG1024	Enoyl-CoA hydratase
AL545_RS03735	COG1028	Short-chain dehydrogenase reductase Sdr
AL545_RS03740	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AL545_RS03745	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AL545_RS03750	COG1845	cytochrome c oxidase, subunit III
AL545_RS03755	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AL545_RS03760	COG0109	protoheme IX farnesyltransferase activity
AL545_RS03765	COG1902	pentaerythritol trinitrate reductase activity
AL545_RS03765	COG0446	pyridine nucleotide-disulphide oxidoreductase
AL545_RS03780	COG1012	belongs to the aldehyde dehydrogenase family
AL545_RS03790	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL545_RS03820	COG1126	abc transporter atp-binding protein
AL545_RS03825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL545_RS03830	COG4215	(ABC) transporter
AL545_RS03835	COG4160	amino acid transport
AL545_RS03900	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AL545_RS03905	COG2176	DNA-directed DNA polymerase activity
AL545_RS03910	COG0517	IMP dehydrogenase activity
AL545_RS03915	COG2186	Transcriptional regulator
AL545_RS03920	COG2186	Transcriptional regulator
AL545_RS03965	COG1917	Cupin 2, conserved barrel domain protein
AL545_RS03970	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL545_RS03975	COG0800	Aldolase
AL545_RS03985	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AL545_RS03990	COG1028	Short-chain dehydrogenase reductase Sdr
AL545_RS03995	COG2847	Copper chaperone PCu(A)C
AL545_RS04065	COG0814	amino acid
AL545_RS04075	COG0243	molybdopterin cofactor binding
AL545_RS04105	COG1116	anion transmembrane transporter activity
AL545_RS04105	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AL545_RS04110	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AL545_RS04115	COG1116	anion transmembrane transporter activity
AL545_RS04120	COG2146	nitrite reductase [NAD(P)H] activity
AL545_RS04120	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AL545_RS04165	COG0515	serine threonine protein kinase
AL545_RS04165	COG2815	serine threonine protein kinase
AL545_RS04200	COG0631	protein serine/threonine phosphatase activity
AL545_RS04270	COG0420	3'-5' exonuclease activity
AL545_RS04275	COG0419	ATPase involved in DNA repair
AL545_RS04285	COG3040	lipid binding
AL545_RS04295	COG1288	antiporter activity
AL545_RS04305	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
AL545_RS04320	COG2425	protein containing a von Willebrand factor type A (vWA) domain
AL545_RS04335	COG0583	DNA-binding transcription factor activity
AL545_RS04340	COG0277	FAD linked oxidase domain protein
AL545_RS04355	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AL545_RS04410	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AL545_RS04435	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AL545_RS04440	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AL545_RS04450	COG2116	formate transmembrane transporter activity
AL545_RS04470	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AL545_RS04510	COG3118	belongs to the thioredoxin family
AL545_RS04515	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AL545_RS04540	COG2271	Major facilitator Superfamily
AL545_RS04545	COG3851	Histidine kinase
AL545_RS04550	COG2197	response regulator
AL545_RS04560	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AL545_RS04565	COG0583	DNA-binding transcription factor activity
AL545_RS04575	COG0243	molybdopterin cofactor binding
AL545_RS04590	COG0384	phenazine biosynthesis protein PhzF
AL545_RS04595	COG1794	racemase activity, acting on amino acids and derivatives
AL545_RS04630	COG1328	CTP reductase activity
AL545_RS04635	COG0602	queuosine metabolic process
AL545_RS04640	COG0534	Mate efflux family protein
AL545_RS04645	COG2207	Transcriptional regulator
AL545_RS04655	COG0189	ligase activity
AL545_RS04655	COG4067	protein conserved in archaea
AL545_RS04665	COG3111	PFAM Bacterial OB fold (BOF) protein
AL545_RS04675	COG0725	ABC transporter, periplasmic molybdate-binding protein
AL545_RS04680	COG4149	molybdate abc transporter
AL545_RS04685	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AL545_RS04695	COG5001	Diguanylate cyclase
AL545_RS04695	COG3706	GGDEF domain
AL545_RS04695	COG4251	negative regulation of phosphorylation
AL545_RS04695	COG2203	Gaf domain
AL545_RS04715	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AL545_RS04720	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AL545_RS04745	COG3140	Belongs to the UPF0181 family
AL545_RS04760	COG0583	DNA-binding transcription factor activity
AL545_RS04780	COG0023	Translation Initiation Factor
AL545_RS04790	COG1181	Belongs to the D-alanine--D-alanine ligase family
AL545_RS04800	COG1042	CoA-binding domain protein
AL545_RS04800	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL545_RS04800	COG0045	succinate-CoA ligase (ADP-forming) activity
AL545_RS04805	COG0583	DNA-binding transcription factor activity
AL545_RS04825	COG5002	protein histidine kinase activity
AL545_RS04825	COG5001	Diguanylate cyclase
AL545_RS04825	COG3447	MASE1 domain protein
AL545_RS04830	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AL545_RS04835	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AL545_RS04840	COG1984	allophanate hydrolase subunit 2
AL545_RS04850	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AL545_RS04855	COG4181	ATPase activity
AL545_RS04865	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AL545_RS04870	COG3300	MHYT domain
AL545_RS04870	COG5001	Diguanylate cyclase
AL545_RS04905	COG4533	DNA binding
AL545_RS04915	COG2050	protein possibly involved in aromatic compounds catabolism
AL545_RS04930	COG2067	long-chain fatty acid transport protein
AL545_RS04935	COG2267	carboxylic ester hydrolase activity
AL545_RS04960	COG0737	Belongs to the 5'-nucleotidase family
AL545_RS04965	COG3593	DNA synthesis involved in DNA repair
AL545_RS04975	COG0583	DNA-binding transcription factor activity
AL545_RS04980	COG2116	formate transmembrane transporter activity
AL545_RS04985	COG2353	YceI-like domain
AL545_RS04990	COG3038	cytochrome b561
AL545_RS05010	COG0513	Belongs to the DEAD box helicase family
AL545_RS05015	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
AL545_RS05025	COG0840	transmembrane signaling receptor activity
AL545_RS05035	COG0546	phosphoglycolate phosphatase activity
AL545_RS05050	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL545_RS05055	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AL545_RS05060	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AL545_RS05075	COG2207	Transcriptional regulator
AL545_RS05080	COG1979	alcohol dehydrogenase
AL545_RS05090	COG1126	abc transporter atp-binding protein
AL545_RS05095	COG0765	amino acid transport
AL545_RS05100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL545_RS05105	COG0765	amino acid transport
AL545_RS05110	COG2200	EAL domain
AL545_RS05110	COG2199	diguanylate cyclase activity
AL545_RS05110	COG2203	Gaf domain
AL545_RS05125	COG1609	Transcriptional regulator
AL545_RS05130	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL545_RS05130	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL545_RS05135	COG1105	Belongs to the carbohydrate kinase PfkB family
AL545_RS05140	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
AL545_RS05140	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL545_RS05140	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL545_RS05170	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AL545_RS05180	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AL545_RS05185	COG0509	glycine decarboxylation via glycine cleavage system
AL545_RS05195	COG0346	lactoylglutathione lyase activity
AL545_RS05210	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AL545_RS05215	COG0583	DNA-binding transcription factor activity
AL545_RS05220	COG0697	spore germination
AL545_RS05225	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AL545_RS05265	COG2176	DNA-directed DNA polymerase activity
AL545_RS05305	COG0242	peptide deformylase activity
AL545_RS05335	COG2239	Acts as a magnesium transporter
AL545_RS05355	COG0346	lactoylglutathione lyase activity
AL545_RS05360	COG1902	pentaerythritol trinitrate reductase activity
AL545_RS05380	COG5642	Protein of unknown function (DUF2384)
AL545_RS05385	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AL545_RS05420	COG2076	Multidrug Resistance protein
AL545_RS05440	COG2962	Rard protein
AL545_RS05455	COG0784	Response regulator, receiver
AL545_RS05455	COG0835	chemotaxis
AL545_RS05465	COG2197	response regulator
AL545_RS05475	COG3706	GGDEF domain
AL545_RS05480	COG2197	response regulator
AL545_RS05485	COG5001	Diguanylate cyclase
AL545_RS05485	COG3300	MHYT domain
AL545_RS05490	COG0784	Response regulator, receiver
AL545_RS05490	COG2205	protein histidine kinase activity
AL545_RS05495	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AL545_RS05515	COG1214	PFAM Peptidase M22, glycoprotease
AL545_RS05515	COG0456	acetyltransferase
AL545_RS05525	COG3069	C4-dicarboxylate transmembrane transporter activity
AL545_RS05550	COG3111	PFAM Bacterial OB fold (BOF) protein
AL545_RS05555	COG1597	lipid kinase activity
AL545_RS05560	COG0583	DNA-binding transcription factor activity
AL545_RS05565	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AL545_RS05595	COG0714	Associated with various cellular activities
AL545_RS05600	COG0641	radical SAM
AL545_RS05605	COG3119	arylsulfatase activity
AL545_RS05615	COG3119	arylsulfatase activity
AL545_RS05620	COG0745	RESPONSE REGULATOR receiver
AL545_RS05635	COG2205	protein histidine kinase activity
AL545_RS05635	COG0784	Response regulator, receiver
AL545_RS05635	COG2198	Histidine kinase
AL545_RS05640	COG1879	ABC-type sugar transport system periplasmic component
AL545_RS05645	COG1803	Methylglyoxal synthase
AL545_RS05650	COG0210	DNA helicase
AL545_RS05655	COG1289	transmembrane transporter activity
AL545_RS05690	COG4771	TonB-dependent receptor
AL545_RS05690	COG1629	transport
AL545_RS05700	COG0789	Transcriptional regulator
AL545_RS05705	COG4604	ABC transporter, ATP-binding protein
AL545_RS05710	COG4605	iron ion homeostasis
AL545_RS05715	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL545_RS05720	COG4607	ABC-type enterochelin transport system periplasmic component
AL545_RS05730	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
AL545_RS05745	COG1609	Transcriptional regulator
AL545_RS05750	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL545_RS05755	COG1879	ABC-type sugar transport system periplasmic component
AL545_RS05760	COG1172	Belongs to the binding-protein-dependent transport system permease family
AL545_RS05765	COG1129	ABC transporter
AL545_RS05770	COG1869	D-ribose catabolic process
AL545_RS05775	COG5001	Diguanylate cyclase
AL545_RS05830	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AL545_RS05840	COG0784	Response regulator, receiver
AL545_RS05840	COG2205	protein histidine kinase activity
AL545_RS05855	COG0330	HflC and HflK could
AL545_RS05870	COG4175	Glycine betaine
AL545_RS05870	COG0517	IMP dehydrogenase activity
AL545_RS05875	COG4176	ABC-type proline glycine betaine transport system permease component
AL545_RS05890	COG1012	belongs to the aldehyde dehydrogenase family
AL545_RS05895	COG1309	transcriptional regulator
AL545_RS05905	COG1028	Short-chain dehydrogenase reductase Sdr
AL545_RS05920	COG1024	Enoyl-CoA hydratase
AL545_RS05925	COG1960	acyl-CoA dehydrogenase activity
AL545_RS05935	COG0183	Belongs to the thiolase family
AL545_RS05945	COG1960	acyl-CoA dehydrogenase activity
AL545_RS05950	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AL545_RS05960	COG4770	biotin carboxylase activity
AL545_RS05975	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AL545_RS05975	COG3264	Mechanosensitive ion channel
AL545_RS05985	COG0110	maltose O-acetyltransferase activity
AL545_RS05990	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL545_RS05995	COG1271	oxidase subunit
AL545_RS06000	COG1294	oxidase, subunit
AL545_RS06015	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AL545_RS06025	COG3527	Alpha-acetolactate decarboxylase
AL545_RS06040	COG0500	methyltransferase
AL545_RS06070	COG1022	Amp-dependent synthetase and ligase
AL545_RS06100	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AL545_RS06105	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL545_RS06105	COG1263	PTS System
AL545_RS06110	COG1486	melibiose metabolic process
AL545_RS06115	COG2188	Transcriptional regulator
AL545_RS06120	COG1320	monovalent cation:proton antiporter activity
AL545_RS06125	COG2212	antiporter activity
AL545_RS06130	COG1863	multisubunit Na H antiporter MnhE subunit
AL545_RS06135	COG0651	ATP synthesis coupled electron transport
AL545_RS06140	COG1006	Multisubunit Na H antiporter MnhC subunit
AL545_RS06145	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AL545_RS06145	COG2111	Na H antiporter
AL545_RS06155	COG0589	response to stress
AL545_RS06160	COG4221	oxidoreductase activity
AL545_RS06165	COG0583	DNA-binding transcription factor activity
AL545_RS06175	COG2814	Major facilitator Superfamily
AL545_RS06240	COG1522	sequence-specific DNA binding
AL545_RS06275	COG0515	serine threonine protein kinase
AL545_RS06300	COG3501	Rhs element vgr protein
AL545_RS06340	COG0739	heme binding
AL545_RS06355	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL545_RS06400	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
AL545_RS06410	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AL545_RS06410	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AL545_RS06425	COG4989	oxidoreductase activity
AL545_RS06440	COG0038	chloride channel
AL545_RS06460	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AL545_RS06475	COG2897	thiosulfate sulfurtransferase activity
AL545_RS06495	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AL545_RS06500	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AL545_RS06510	COG2814	Major facilitator Superfamily
AL545_RS06515	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AL545_RS06530	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AL545_RS06540	COG0840	transmembrane signaling receptor activity
AL545_RS06560	COG2195	Cleaves the N-terminal amino acid of tripeptides
AL545_RS06575	COG2197	response regulator
AL545_RS06580	COG3850	Histidine kinase
AL545_RS06585	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AL545_RS06595	COG0243	molybdopterin cofactor binding
AL545_RS06605	COG3005	denitrification pathway
AL545_RS06615	COG3243	poly(R)-hydroxyalkanoic acid synthase
AL545_RS06625	COG0183	Belongs to the thiolase family
AL545_RS06635	COG1280	lysine exporter protein (LysE YggA)
AL545_RS06645	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL545_RS06650	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL545_RS06705	COG1846	Transcriptional regulator
AL545_RS06710	COG0784	Response regulator, receiver
AL545_RS06710	COG2205	protein histidine kinase activity
AL545_RS06715	COG1879	ABC-type sugar transport system periplasmic component
AL545_RS06720	COG2827	Endonuclease containing a URI domain
AL545_RS06725	COG3132	Protein of unknown function, DUF480
AL545_RS06740	COG0534	Mate efflux family protein
AL545_RS06745	COG5002	protein histidine kinase activity
AL545_RS06745	COG0784	Response regulator, receiver
AL545_RS06745	COG2205	protein histidine kinase activity
AL545_RS06770	COG0583	DNA-binding transcription factor activity
AL545_RS06785	COG0531	amino acid
AL545_RS06800	COG2205	protein histidine kinase activity
AL545_RS06805	COG0745	RESPONSE REGULATOR receiver
AL545_RS06830	COG1566	PFAM secretion protein HlyD family protein
AL545_RS06835	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AL545_RS06840	COG2239	Acts as a magnesium transporter
AL545_RS06845	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AL545_RS06850	COG0402	S-adenosylhomocysteine deaminase activity
AL545_RS06855	COG1418	mRNA catabolic process
AL545_RS06870	COG2814	Major facilitator Superfamily
AL545_RS06880	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AL545_RS06900	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AL545_RS06915	COG0745	RESPONSE REGULATOR receiver
AL545_RS06920	COG2205	protein histidine kinase activity
AL545_RS06930	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AL545_RS06935	COG2194	sulfuric ester hydrolase activity
AL545_RS06955	COG4667	esterase of the alpha-beta hydrolase superfamily
AL545_RS06960	COG1741	Belongs to the pirin family
AL545_RS06965	COG1278	Cold shock
AL545_RS06980	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AL545_RS06985	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AL545_RS06985	COG0678	peroxiredoxin activity
AL545_RS06995	COG1686	Belongs to the peptidase S11 family
AL545_RS07005	COG0625	glutathione transferase activity
AL545_RS07015	COG1621	beta-fructofuranosidase activity
AL545_RS07020	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL545_RS07025	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL545_RS07025	COG1263	PTS System
AL545_RS07045	COG4771	TonB-dependent receptor
AL545_RS07050	COG0583	DNA-binding transcription factor activity
AL545_RS07060	COG1404	Belongs to the peptidase S8 family
AL545_RS07065	COG1028	Short-chain dehydrogenase reductase Sdr
AL545_RS07080	COG3746	phosphate-selective porin O and P
AL545_RS07095	COG0300	oxidoreductase activity
AL545_RS07100	COG0583	DNA-binding transcription factor activity
AL545_RS07105	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AL545_RS07105	COG2207	Transcriptional regulator
AL545_RS07110	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL545_RS07140	COG0513	Belongs to the DEAD box helicase family
AL545_RS07150	COG0583	DNA-binding transcription factor activity
AL545_RS07165	COG1902	pentaerythritol trinitrate reductase activity
AL545_RS07180	COG1028	Short-chain dehydrogenase reductase Sdr
AL545_RS07190	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL545_RS07195	COG0006	proline dipeptidase activity
AL545_RS07200	COG3608	succinylglutamate desuccinylase aspartoacylase
AL545_RS07205	COG1522	sequence-specific DNA binding
AL545_RS07210	COG1012	belongs to the aldehyde dehydrogenase family
AL545_RS07215	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AL545_RS07220	COG3122	Protein conserved in bacteria
AL545_RS07235	COG0583	DNA-binding transcription factor activity
AL545_RS07240	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AL545_RS07245	COG0252	asparaginase activity
AL545_RS07250	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AL545_RS07265	COG2197	response regulator
AL545_RS07270	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AL545_RS07295	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL545_RS07325	COG3842	ATPase activity
AL545_RS07345	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL545_RS07370	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AL545_RS07375	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AL545_RS07410	COG0583	DNA-binding transcription factor activity
AL545_RS07420	COG4948	Mandelate Racemase Muconate Lactonizing
AL545_RS07455	COG1342	Belongs to the UPF0251 family
AL545_RS07465	COG4176	ABC-type proline glycine betaine transport system permease component
AL545_RS07470	COG4175	Glycine betaine
AL545_RS07470	COG3448	diguanylate cyclase activity
AL545_RS07475	COG3015	lipoprotein NlpE involved in copper resistance
AL545_RS07480	COG3713	MltA-interacting MipA family protein
AL545_RS07495	COG0583	DNA-binding transcription factor activity
AL545_RS07520	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AL545_RS07530	COG1335	isochorismatase
AL545_RS07545	COG1349	DNA-binding transcription factor activity
AL545_RS07555	COG2070	2-Nitropropane dioxygenase
AL545_RS07560	COG0531	amino acid
AL545_RS07565	COG4302	ethanolamine ammonia-lyase activity
AL545_RS07570	COG4303	Ethanolamine ammonia lyase large subunit
AL545_RS07580	COG1309	transcriptional regulator
AL545_RS07600	COG1280	lysine exporter protein (LysE YggA)
AL545_RS07610	COG0459	protein refolding
AL545_RS07615	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AL545_RS07625	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AL545_RS07640	COG1304	FMN binding
AL545_RS07665	COG4786	Flagellar basal body rod
AL545_RS07665	COG1256	bacterial-type flagellum assembly
AL545_RS07675	COG1706	bacterial-type flagellum-dependent cell motility
AL545_RS07680	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AL545_RS07685	COG4786	Flagellar basal body rod
AL545_RS07690	COG4787	bacterial-type flagellum-dependent cell motility
AL545_RS07705	COG1558	bacterial-type flagellum-dependent cell motility
AL545_RS07710	COG1815	bacterial-type flagellum-dependent cell motility
AL545_RS07730	COG1388	LysM domain
AL545_RS07730	COG0741	lytic transglycosylase activity
AL545_RS07735	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AL545_RS07755	COG1760	l-serine dehydratase
AL545_RS07770	COG0583	DNA-binding transcription factor activity
AL545_RS07780	COG2866	Carboxypeptidase
AL545_RS07785	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AL545_RS07795	COG2990	Protein conserved in bacteria
AL545_RS07820	COG3842	ATPase activity
AL545_RS07825	COG1840	ABC-type Fe3 transport system, periplasmic component
AL545_RS07835	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AL545_RS07855	COG3240	lipase activity
AL545_RS07860	COG1309	transcriptional regulator
AL545_RS07875	COG1136	(ABC) transporter
AL545_RS07875	COG0577	efflux transmembrane transporter activity
AL545_RS07880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL545_RS07885	COG2067	long-chain fatty acid transport protein
AL545_RS07895	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
AL545_RS07910	COG1011	Hydrolase
AL545_RS07950	COG0110	maltose O-acetyltransferase activity
AL545_RS07955	COG1765	OsmC-like protein
AL545_RS07960	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL545_RS07960	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL545_RS07975	COG3046	protein related to deoxyribodipyrimidine photolyase
AL545_RS07980	COG0415	Belongs to the DNA photolyase family
AL545_RS07985	COG3706	GGDEF domain
AL545_RS08000	COG3706	GGDEF domain
AL545_RS08015	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AL545_RS08035	COG3033	Beta-eliminating lyase
AL545_RS08045	COG1271	oxidase subunit
AL545_RS08050	COG1294	oxidase, subunit
AL545_RS08065	COG0579	oxidoreductase
AL545_RS08090	COG3706	GGDEF domain
AL545_RS08100	COG4191	Histidine kinase
AL545_RS08120	COG0187	DNA topoisomerase II activity
AL545_RS08145	COG0071	Belongs to the small heat shock protein (HSP20) family
AL545_RS08150	COG3977	Valine--pyruvate aminotransferase
AL545_RS08155	COG0366	Alpha amylase catalytic
AL545_RS08170	COG2119	membrane
AL545_RS08180	COG0425	Belongs to the sulfur carrier protein TusA family
AL545_RS08195	COG0604	alcohol dehydrogenase
AL545_RS08200	COG0183	Belongs to the thiolase family
AL545_RS08210	COG1739	Uncharacterized protein family UPF0029
AL545_RS08215	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AL545_RS08265	COG2132	Multicopper oxidase
AL545_RS08285	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AL545_RS08290	COG2104	thiamine diphosphate biosynthetic process
AL545_RS08305	COG0006	proline dipeptidase activity
AL545_RS08305	COG0006	proline dipeptidase activity
AL545_RS08335	COG3220	belongs to the UPF0276 family
AL545_RS08345	COG0210	DNA helicase
AL545_RS08355	COG0405	Gamma-glutamyltransferase
AL545_RS08360	COG1280	lysine exporter protein (LysE YggA)
AL545_RS08370	COG2962	Rard protein
AL545_RS08375	COG0514	ATP-dependent DNA helicase (RecQ)
AL545_RS08390	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AL545_RS08400	COG0248	Ppx GppA phosphatase
AL545_RS08405	COG0513	Belongs to the DEAD box helicase family
AL545_RS08410	COG3118	belongs to the thioredoxin family
AL545_RS08425	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AL545_RS08430	COG0633	Ferredoxin
AL545_RS08475	COG3071	HemY protein
AL545_RS08480	COG2959	enzyme of heme biosynthesis
AL545_RS08485	COG1587	Uroporphyrinogen-III synthase
AL545_RS08490	COG0181	hydroxymethylbilane synthase activity
AL545_RS08495	COG3072	Adenylate cyclase
AL545_RS08500	COG1965	Belongs to the frataxin family
AL545_RS08510	COG0019	diaminopimelate decarboxylase activity
AL545_RS08525	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AL545_RS08530	COG1011	Hydrolase
AL545_RS08535	COG3287	FIST C domain
AL545_RS08535	COG2200	EAL domain
AL545_RS08535	COG2199	diguanylate cyclase activity
AL545_RS08540	COG3148	PFAM DTW domain containing protein
AL545_RS08555	COG0561	phosphatase activity
AL545_RS08560	COG2267	carboxylic ester hydrolase activity
AL545_RS08565	COG1280	lysine exporter protein (LysE YggA)
AL545_RS08570	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AL545_RS08575	COG0640	Transcriptional regulator
AL545_RS08580	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AL545_RS08625	COG2095	MarC family integral membrane protein
AL545_RS08635	COG0742	ribosomal rna small subunit methyltransferase
AL545_RS08640	COG0552	protein localization to endoplasmic reticulum
AL545_RS08645	COG2884	Cell division ATP-binding protein ftsE
AL545_RS08650	COG2177	Part of the ABC transporter FtsEX involved in
AL545_RS08665	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AL545_RS08670	COG0705	Rhomboid family
AL545_RS08675	COG1580	Controls the rotational direction of flagella during chemotaxis
AL545_RS08680	COG3161	chorismate lyase activity
AL545_RS08685	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AL545_RS08690	COG2937	Belongs to the GPAT DAPAT family
AL545_RS08700	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AL545_RS08710	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
AL545_RS08715	COG0534	Mate efflux family protein
AL545_RS08720	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL545_RS08785	COG3339	Conserved Protein
AL545_RS08830	COG4206	TonB-dependent receptor
AL545_RS08895	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AL545_RS08905	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AL545_RS08910	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AL545_RS08910	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AL545_RS08945	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AL545_RS08955	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AL545_RS08960	COG0250	Participates in transcription elongation, termination and antitermination
AL545_RS08975	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AL545_RS08980	COG0222	ribosome binding
AL545_RS08985	COG0085	RNA polymerase activity
AL545_RS08990	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AL545_RS08995	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
AL545_RS09000	COG2816	NAD+ diphosphatase activity
AL545_RS09005	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AL545_RS09010	COG1573	uracil-dna glycosylase
AL545_RS09020	COG3068	Protein conserved in bacteria
AL545_RS09025	COG1253	flavin adenine dinucleotide binding
AL545_RS09040	COG0151	Belongs to the GarS family
AL545_RS09045	COG0138	bifunctional purine biosynthesis protein purh
AL545_RS09055	COG0789	Transcriptional regulator
AL545_RS09060	COG3710	Transcriptional regulator
AL545_RS09070	COG0531	amino acid
AL545_RS09075	COG1982	Orn Lys Arg decarboxylase major
AL545_RS09140	COG0488	(ABC) transporter
AL545_RS09150	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AL545_RS09155	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AL545_RS09160	COG2264	protein methyltransferase activity
AL545_RS09165	COG0439	Biotin carboxylase
AL545_RS09170	COG0511	ligase activity, forming carbon-carbon bonds
AL545_RS09175	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AL545_RS09180	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AL545_RS09195	COG2814	Major facilitator Superfamily
AL545_RS09220	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AL545_RS09230	COG3263	regulation of cellular component size
AL545_RS09240	COG4232	protein-disulfide reductase activity
AL545_RS09245	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AL545_RS09250	COG1027	Aspartate ammonia-lyase
AL545_RS09255	COG3030	protein affecting phage T7 exclusion by the F plasmid
AL545_RS09260	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AL545_RS09270	COG2205	protein histidine kinase activity
AL545_RS09275	COG0745	RESPONSE REGULATOR receiver
AL545_RS09280	COG3678	ATP-independent chaperone mediated protein folding
AL545_RS09290	COG0205	6-phosphofructokinase activity
AL545_RS09300	COG0534	Mate efflux family protein
AL545_RS09310	COG0459	protein refolding
AL545_RS09320	COG1285	pathogenesis
AL545_RS09325	COG1509	lysine 2,3-aminomutase activity
AL545_RS09340	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
AL545_RS09345	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
AL545_RS09350	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AL545_RS09355	COG1053	succinate dehydrogenase
AL545_RS09360	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
AL545_RS09380	COG4942	peptidase
AL545_RS09385	COG1045	serine acetyltransferase
AL545_RS09390	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AL545_RS09395	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AL545_RS09400	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AL545_RS09405	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AL545_RS09415	COG3273	potassium ion transport
AL545_RS09415	COG0471	metal ion transport
AL545_RS09420	COG0688	phosphatidylethanolamine metabolic process
AL545_RS09425	COG1162	GTPase activity
AL545_RS09430	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AL545_RS09495	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AL545_RS09505	COG0802	atpase or kinase
AL545_RS09515	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AL545_RS09520	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AL545_RS09530	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AL545_RS09535	COG0330	HflC and HflK could
AL545_RS09540	COG0330	HflC and HflK could
AL545_RS09545	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
AL545_RS09550	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AL545_RS09560	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
AL545_RS09565	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AL545_RS09565	COG1017	nitric oxide dioxygenase activity
AL545_RS09570	COG1959	2 iron, 2 sulfur cluster binding
AL545_RS09575	COG0557	exoribonuclease II activity
AL545_RS09580	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AL545_RS09585	COG0546	phosphoglycolate phosphatase activity
AL545_RS09590	COG0180	Tryptophanyl-tRNA synthetase
AL545_RS09605	COG0512	Glutamine amidotransferase of anthranilate synthase
AL545_RS09610	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AL545_RS09630	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AL545_RS09635	COG3954	Phosphoribulokinase
AL545_RS09645	COG0429	hydrolase of the alpha beta-hydrolase fold
AL545_RS09655	COG0488	(ABC) transporter
AL545_RS09660	COG2249	NAD(P)H dehydrogenase (quinone) activity
AL545_RS09675	COG1047	Peptidyl-prolyl cis-trans
AL545_RS09685	COG1446	asparaginase
AL545_RS09700	COG0545	Peptidyl-prolyl cis-trans isomerase
AL545_RS09705	COG2964	Protein conserved in bacteria
AL545_RS09710	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
AL545_RS09715	COG2923	Belongs to the DsrF TusC family
AL545_RS09735	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AL545_RS09740	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AL545_RS09755	COG0281	malic enzyme
AL545_RS09760	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
AL545_RS09765	COG0626	cystathionine gamma-synthase activity
AL545_RS09770	COG0527	aspartate kinase activity
AL545_RS09770	COG0460	homoserine dehydrogenase
AL545_RS09775	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AL545_RS09785	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AL545_RS09795	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AL545_RS09805	COG0137	argininosuccinate synthase activity
AL545_RS09810	COG0165	Argininosuccinate lyase
AL545_RS09810	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AL545_RS09820	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL545_RS09825	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AL545_RS09825	COG0678	peroxiredoxin activity
AL545_RS09835	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AL545_RS09865	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AL545_RS09870	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AL545_RS09880	COG0338	D12 class N6 adenine-specific DNA methyltransferase
AL545_RS09885	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AL545_RS09890	COG0360	Binds together with S18 to 16S ribosomal RNA
AL545_RS09895	COG2965	DNA replication, synthesis of RNA primer
AL545_RS09920	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AL545_RS09925	COG0432	Pfam Uncharacterised protein family UPF0047
AL545_RS09930	COG0166	Belongs to the GPI family
AL545_RS09940	COG0735	belongs to the Fur family
AL545_RS09945	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AL545_RS09965	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AL545_RS09970	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AL545_RS09975	COG0175	sulfate reduction
AL545_RS10040	COG0646	methionine synthase
AL545_RS10040	COG1410	methionine synthase
AL545_RS10045	COG0527	aspartate kinase activity
AL545_RS10055	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AL545_RS10065	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AL545_RS10080	COG0629	single-stranded DNA binding
AL545_RS10085	COG2200	EAL domain
AL545_RS10085	COG2199	diguanylate cyclase activity
AL545_RS10105	COG1450	Type ii and iii secretion system protein
AL545_RS10110	COG3409	Peptidoglycan-binding domain 1 protein
AL545_RS10110	COG3267	Type II secretory pathway component ExeA
AL545_RS10120	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AL545_RS10125	COG1459	type II secretion system
AL545_RS10135	COG2165	general secretion pathway protein
AL545_RS10170	COG1077	Cell shape determining protein MreB Mrl
AL545_RS10175	COG1792	Involved in formation and maintenance of cell shape
AL545_RS10180	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AL545_RS10185	COG0424	maF-like protein
AL545_RS10195	COG3164	Protein of unknown function
AL545_RS10200	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AL545_RS10205	COG0312	modulator of DNA gyrase
AL545_RS10210	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AL545_RS10215	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AL545_RS10225	COG0564	pseudouridine synthase activity
AL545_RS10230	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AL545_RS10235	COG3028	Belongs to the UPF0307 family
AL545_RS10240	COG0312	modulator of DNA gyrase
AL545_RS10245	COG2239	Acts as a magnesium transporter
AL545_RS10250	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL545_RS10255	COG1660	Displays ATPase and GTPase activities
AL545_RS10260	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL545_RS10265	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AL545_RS10275	COG1137	ATPase activity
AL545_RS10280	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AL545_RS10290	COG0517	IMP dehydrogenase activity
AL545_RS10290	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AL545_RS10300	COG1127	ABC transporter
AL545_RS10305	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AL545_RS10310	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AL545_RS10315	COG2854	intermembrane phospholipid transfer
AL545_RS10325	COG5007	Belongs to the BolA IbaG family
AL545_RS10330	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AL545_RS10335	COG0204	Acyl-transferase
AL545_RS10340	COG0251	oxidation-reduction process
AL545_RS10345	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
AL545_RS10350	COG0540	Belongs to the ATCase OTCase family
AL545_RS10380	COG0456	acetyltransferase
AL545_RS10390	COG0525	valine-tRNA ligase activity
AL545_RS10395	COG2927	DNA polymerase III (CHI subunit)
AL545_RS10400	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AL545_RS10405	COG0795	lipopolysaccharide-transporting ATPase activity
AL545_RS10410	COG0795	lipopolysaccharide-transporting ATPase activity
AL545_RS10425	COG1028	Short-chain dehydrogenase reductase Sdr
AL545_RS10435	COG0726	polysaccharide deacetylase
AL545_RS10440	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AL545_RS10445	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AL545_RS10450	COG1447	Phosphotransferase system cellobiose-specific component IIA
AL545_RS10455	COG1486	melibiose metabolic process
AL545_RS10460	COG3394	polysaccharide catabolic process
AL545_RS10465	COG1609	Transcriptional regulator
AL545_RS10470	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AL545_RS10550	COG0840	transmembrane signaling receptor activity
AL545_RS10595	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AL545_RS10605	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AL545_RS10615	COG2066	Belongs to the glutaminase family
AL545_RS10620	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AL545_RS10625	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AL545_RS10635	COG1872	DUF167
AL545_RS10640	COG0762	integral membrane protein
AL545_RS10645	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AL545_RS10650	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AL545_RS10665	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AL545_RS10670	COG1678	Uncharacterized ACR, COG1678
AL545_RS10675	COG0189	ligase activity
AL545_RS10680	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AL545_RS10685	COG2356	endonuclease I
AL545_RS10700	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AL545_RS10710	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AL545_RS10715	COG0583	DNA-binding transcription factor activity
AL545_RS10720	COG4771	TonB-dependent receptor
AL545_RS10735	COG0191	fructose-bisphosphate aldolase activity
AL545_RS10740	COG0668	transmembrane transport
AL545_RS10755	COG0583	DNA-binding transcription factor activity
AL545_RS10765	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AL545_RS10770	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AL545_RS10775	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AL545_RS10785	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
AL545_RS10795	COG3079	Belongs to the UPF0149 family
AL545_RS10800	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AL545_RS10805	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AL545_RS10825	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AL545_RS10835	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AL545_RS10845	COG1595	DNA-templated transcription, initiation
AL545_RS10860	COG3086	response to oxidative stress
AL545_RS10865	COG0481	GTPase activity
AL545_RS10870	COG0681	Belongs to the peptidase S26 family
AL545_RS10880	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AL545_RS10885	COG1381	Involved in DNA repair and RecF pathway recombination
AL545_RS10890	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AL545_RS10895	COG0736	holo-[acyl-carrier-protein] synthase activity
AL545_RS10910	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AL545_RS10920	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AL545_RS10925	COG3956	TIGRFAM MazG family protein
AL545_RS10930	COG0504	CTP synthase activity
AL545_RS10935	COG0148	phosphopyruvate hydratase activity
AL545_RS10940	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AL545_RS10945	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AL545_RS10950	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AL545_RS10960	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AL545_RS10965	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AL545_RS10975	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AL545_RS10980	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AL545_RS10985	COG1546	Belongs to the CinA family
AL545_RS10990	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AL545_RS10995	COG2137	regulation of response to DNA damage stimulus
AL545_RS11000	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AL545_RS11005	COG0527	aspartate kinase activity
AL545_RS11065	COG3630	sodium ion export across plasma membrane
AL545_RS11070	COG5016	pyruvate
AL545_RS11070	COG0511	ligase activity, forming carbon-carbon bonds
AL545_RS11075	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
AL545_RS11085	COG1238	metal cluster binding
AL545_RS11090	COG0612	Peptidase, M16
AL545_RS11105	COG1854	S-ribosylhomocysteine lyase activity
AL545_RS11110	COG4536	flavin adenine dinucleotide binding
AL545_RS11115	COG4137	Cytochrome C assembly protein
AL545_RS11120	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AL545_RS11125	COG0228	four-way junction DNA binding
AL545_RS11130	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AL545_RS11145	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AL545_RS11150	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
AL545_RS11155	COG0237	dephospho-CoA kinase activity
AL545_RS11165	COG1459	type II secretion system
AL545_RS11170	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AL545_RS11180	COG0157	Belongs to the NadC ModD family
AL545_RS11190	COG2186	Transcriptional regulator
AL545_RS11195	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AL545_RS11200	COG0508	dehydrogenase complex catalyzes the overall conversion of
AL545_RS11205	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL545_RS11220	COG0288	reversible hydration of carbon dioxide
AL545_RS11225	COG0659	secondary active sulfate transmembrane transporter activity
AL545_RS11230	COG1131	(ABC) transporter
AL545_RS11235	COG0842	Transport permease protein
AL545_RS11245	COG1560	Kdo2-lipid A biosynthetic process
AL545_RS11250	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AL545_RS11255	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AL545_RS11260	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AL545_RS11270	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AL545_RS11280	COG1489	DNA binding
AL545_RS11285	COG1643	Atp-dependent helicase
AL545_RS11290	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AL545_RS11295	COG1752	Esterase of the alpha-beta hydrolase superfamily
AL545_RS11300	COG1049	propionate catabolic process, 2-methylcitrate cycle
AL545_RS11305	COG3112	Uncharacterised protein family (UPF0231)
AL545_RS11315	COG0004	ammonium transporteR
AL545_RS11320	COG1840	ABC-type Fe3 transport system, periplasmic component
AL545_RS11330	COG3842	ATPase activity
AL545_RS11335	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AL545_RS11350	COG2971	BadF BadG BcrA BcrD
AL545_RS11360	COG4608	Belongs to the ABC transporter superfamily
AL545_RS11365	COG0444	Belongs to the ABC transporter superfamily
AL545_RS11370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL545_RS11380	COG0747	negative chemotaxis
AL545_RS11385	COG0784	Response regulator, receiver
AL545_RS11385	COG2205	protein histidine kinase activity
AL545_RS11395	COG0628	permease
AL545_RS11420	COG0739	heme binding
AL545_RS11425	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AL545_RS11435	COG2027	D-alanyl-D-alanine carboxypeptidase
AL545_RS11440	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AL545_RS11445	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AL545_RS11450	COG1534	Rna-binding protein
AL545_RS11455	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AL545_RS11460	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AL545_RS11465	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AL545_RS11470	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AL545_RS11480	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AL545_RS11495	COG0779	Required for maturation of 30S ribosomal subunits
AL545_RS11500	COG0195	Participates in both transcription termination and antitermination
AL545_RS11505	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AL545_RS11510	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AL545_RS11515	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AL545_RS11520	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AL545_RS11525	COG1185	polyribonucleotide nucleotidyltransferase activity
AL545_RS11540	COG0534	Mate efflux family protein
AL545_RS11545	COG0826	peptidase U32
AL545_RS11550	COG0826	peptidase U32
AL545_RS11565	COG3154	lipid carrier protein
AL545_RS11570	COG3153	acetyltransferase
AL545_RS11600	COG0084	hydrolase, TatD family'
AL545_RS11605	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AL545_RS11610	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AL545_RS11615	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AL545_RS11620	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
AL545_RS11625	COG0813	purine-nucleoside phosphorylase activity
AL545_RS11635	COG0560	Phosphoserine phosphatase
AL545_RS11645	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AL545_RS11650	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AL545_RS11655	COG0583	DNA-binding transcription factor activity
AL545_RS11665	COG1022	Amp-dependent synthetase and ligase
AL545_RS11705	COG0583	DNA-binding transcription factor activity
AL545_RS11710	COG1609	Transcriptional regulator
AL545_RS11735	COG0598	Magnesium transport protein CorA
AL545_RS11740	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AL545_RS11745	COG1349	DNA-binding transcription factor activity
AL545_RS11750	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AL545_RS11755	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AL545_RS11765	COG2271	Major facilitator Superfamily
AL545_RS11770	COG0584	glycerophosphoryl diester phosphodiesterase
AL545_RS11775	COG2171	N-acyltransferase activity
AL545_RS11790	COG3141	response to X-ray
AL545_RS11810	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AL545_RS11820	COG1074	ATP-dependent DNA helicase activity
AL545_RS11825	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AL545_RS11835	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AL545_RS11835	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AL545_RS11850	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
AL545_RS11855	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AL545_RS11860	COG2166	iron-sulfur cluster assembly
AL545_RS11865	COG3706	GGDEF domain
AL545_RS11870	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AL545_RS11875	COG0693	protein deglycase activity
AL545_RS11880	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AL545_RS11885	COG3248	Nucleoside-binding outer membrane protein
AL545_RS11905	COG1595	DNA-templated transcription, initiation
AL545_RS11925	COG3056	Lipoprotein
AL545_RS11930	COG2813	Specifically methylates the guanine in position
AL545_RS11935	COG0271	Belongs to the BolA IbaG family
AL545_RS11945	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AL545_RS11950	COG1805	sodium ion transport
AL545_RS11955	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AL545_RS11960	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AL545_RS11965	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AL545_RS11970	COG2871	sodium ion transport
AL545_RS11975	COG1477	protein flavinylation
AL545_RS11995	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AL545_RS12000	COG0514	ATP-dependent DNA helicase (RecQ)
AL545_RS12020	COG0733	neurotransmitter:sodium symporter activity
AL545_RS12040	COG0442	prolyl-tRNA aminoacylation
AL545_RS12045	COG1720	tRNA m6t6A37 methyltransferase activity
AL545_RS12050	COG0254	rRNA binding
AL545_RS12060	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AL545_RS12085	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AL545_RS12090	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AL545_RS12125	COG0564	pseudouridine synthase activity
AL545_RS12135	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AL545_RS12140	COG0024	Methionine aminopeptidase
AL545_RS12145	COG0052	Belongs to the universal ribosomal protein uS2 family
AL545_RS12150	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AL545_RS12155	COG0528	UMP kinase activity
AL545_RS12160	COG0233	cytoplasmic translational termination
AL545_RS12165	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AL545_RS12170	COG0575	Belongs to the CDS family
AL545_RS12175	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AL545_RS12180	COG0750	zinc metalloprotease
AL545_RS12190	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
AL545_RS12195	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AL545_RS12205	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AL545_RS12210	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AL545_RS12220	COG0587	DNA-directed DNA polymerase activity
AL545_RS12225	COG0825	malonyl-CoA metabolic process
AL545_RS12240	COG0347	Belongs to the P(II) protein family
AL545_RS12245	COG3021	interspecies interaction between organisms
AL545_RS12255	COG0741	lytic transglycosylase activity
AL545_RS12255	COG1388	LysM domain
AL545_RS12260	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AL545_RS12265	COG2226	methyltransferase
AL545_RS12270	COG0328	RNA-DNA hybrid ribonuclease activity
AL545_RS12305	COG1960	acyl-CoA dehydrogenase activity
AL545_RS12310	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AL545_RS12315	COG0121	glutamine amidotransferase
AL545_RS12320	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AL545_RS12325	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AL545_RS12330	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AL545_RS12335	COG2233	PERMEase
AL545_RS12355	COG4783	chaperone-mediated protein folding
AL545_RS12370	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AL545_RS12380	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AL545_RS12385	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
AL545_RS12400	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AL545_RS12405	COG1393	Belongs to the ArsC family
AL545_RS12430	COG2837	iron assimilation
AL545_RS12435	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL545_RS12445	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL545_RS12450	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL545_RS12455	COG1334	flagellar protein FlaG
AL545_RS12460	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AL545_RS12470	COG1516	flagellar protein fliS
AL545_RS12490	COG1677	Flagellar hook-basal body complex protein FliE
AL545_RS12500	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AL545_RS12555	COG1987	bacterial-type flagellum assembly
AL545_RS12560	COG1684	flagellar biosynthetic protein fliR
AL545_RS12595	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
AL545_RS12600	COG2198	Histidine kinase
AL545_RS12600	COG0643	Histidine kinase
AL545_RS12600	COG0784	Response regulator, receiver
AL545_RS12605	COG2201	protein-glutamate methylesterase activity
AL545_RS12610	COG1192	Involved in chromosome partitioning
AL545_RS12620	COG0835	chemotaxis
AL545_RS12630	COG4133	protoheme IX ABC transporter activity
AL545_RS12635	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AL545_RS12640	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AL545_RS12645	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AL545_RS12650	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AL545_RS12655	COG1138	Cytochrome C-type biogenesis protein
AL545_RS12660	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AL545_RS12670	COG3088	subunit of a heme lyase
AL545_RS12670	COG4235	cytochrome complex assembly
AL545_RS12680	COG2067	long-chain fatty acid transport protein
AL545_RS12705	COG0183	Belongs to the thiolase family
AL545_RS12710	COG1024	Enoyl-CoA hydratase
AL545_RS12710	COG1250	3-hydroxyacyl-CoA dehydrogenase
AL545_RS12725	COG2062	phosphohistidine phosphatase, SixA
AL545_RS12730	COG2840	Smr protein MutS2
AL545_RS12735	COG2890	protein-(glutamine-N5) methyltransferase activity
AL545_RS12740	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AL545_RS12745	COG2860	membrane
AL545_RS12755	COG3101	peptidyl-lysine hydroxylation
AL545_RS12770	COG0431	NADPH-dependent FMN reductase
AL545_RS12775	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AL545_RS12775	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AL545_RS12780	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AL545_RS12790	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AL545_RS12795	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AL545_RS12805	COG0101	tRNA pseudouridine synthase activity
AL545_RS12815	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AL545_RS12820	COG0285	dihydrofolate synthase activity
AL545_RS12825	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
AL545_RS12830	COG1286	toxin biosynthetic process
AL545_RS12835	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AL545_RS12840	COG0583	DNA-binding transcription factor activity
AL545_RS12845	COG0745	RESPONSE REGULATOR receiver
AL545_RS12855	COG2832	Protein of unknown function (DUF454)
AL545_RS12860	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AL545_RS12875	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AL545_RS12880	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AL545_RS12890	COG2261	transglycosylase associated protein
AL545_RS12895	COG2983	Belongs to the UPF0260 family
AL545_RS12900	COG0668	transmembrane transport
AL545_RS12905	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
AL545_RS12910	COG0346	lactoylglutathione lyase activity
AL545_RS12920	COG1785	Belongs to the alkaline phosphatase family
AL545_RS12940	COG2226	methyltransferase
AL545_RS12955	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AL545_RS12960	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL545_RS12970	COG3139	Protein of unknown function (DUF1315)
AL545_RS12975	COG0252	asparaginase activity
AL545_RS12980	COG0616	signal peptide processing
AL545_RS12985	COG1902	pentaerythritol trinitrate reductase activity
AL545_RS12985	COG0446	pyridine nucleotide-disulphide oxidoreductase
AL545_RS12995	COG0778	Nitroreductase
AL545_RS13000	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AL545_RS13015	COG0123	including yeast histone deacetylase and acetoin utilization protein
AL545_RS13030	COG3082	Protein of unknown function (DUF1414)
AL545_RS13035	COG3081	Nucleoid-associated protein
AL545_RS13050	COG1757	Na H antiporter
AL545_RS13055	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AL545_RS13060	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AL545_RS13065	COG2095	MarC family integral membrane protein
AL545_RS13070	COG1012	belongs to the aldehyde dehydrogenase family
AL545_RS13070	COG1454	alcohol dehydrogenase
AL545_RS13095	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AL545_RS13110	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AL545_RS13200	COG4695	Portal protein
AL545_RS13335	COG2056	Na+-H+ antiporter family
AL545_RS13340	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AL545_RS13350	COG2885	chlorophyll binding
AL545_RS13360	COG0346	lactoylglutathione lyase activity
AL545_RS13365	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AL545_RS13370	COG4660	Part of a membrane complex involved in electron transport
AL545_RS13375	COG4659	FMN binding
AL545_RS13380	COG4658	electron transport chain
AL545_RS13385	COG4656	Part of a membrane complex involved in electron transport
AL545_RS13390	COG2878	Part of a membrane complex involved in electron transport
AL545_RS13395	COG4657	Part of a membrane complex involved in electron transport
AL545_RS13400	COG1882	Formate acetyltransferase
AL545_RS13410	COG0556	nucleotide-excision repair
AL545_RS13415	COG2204	response regulator
AL545_RS13420	COG2198	Histidine kinase
AL545_RS13425	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AL545_RS13430	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AL545_RS13435	COG0521	Mo-molybdopterin cofactor biosynthetic process
AL545_RS13440	COG0315	cyclic pyranopterin monophosphate synthase activity
AL545_RS13445	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AL545_RS13450	COG0314	molybdopterin synthase activity
AL545_RS13460	COG0601	transmembrane transport
AL545_RS13465	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL545_RS13470	COG0444	Belongs to the ABC transporter superfamily
AL545_RS13480	COG0435	Glutathione S-transferase
AL545_RS13490	COG0280	phosphate acetyltransferase
AL545_RS13490	COG0857	belongs to the CobB CobQ family
AL545_RS13495	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AL545_RS13500	COG3092	negative regulation of chromosome organization
AL545_RS13510	COG4120	Belongs to the binding-protein-dependent transport system permease family
AL545_RS13515	COG1122	ATPase activity
AL545_RS13520	COG0366	Alpha amylase catalytic
AL545_RS13525	COG3706	GGDEF domain
AL545_RS13530	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AL545_RS13535	COG0653	protein targeting
AL545_RS13540	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AL545_RS13545	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AL545_RS13550	COG2186	Transcriptional regulator
AL545_RS13560	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL545_RS13560	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL545_RS13570	COG0572	uridine kinase
AL545_RS13580	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
AL545_RS13585	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AL545_RS13590	COG0659	secondary active sulfate transmembrane transporter activity
AL545_RS13600	COG1530	ribonuclease E activity
AL545_RS13610	COG0564	pseudouridine synthase activity
AL545_RS13615	COG0424	maF-like protein
AL545_RS13620	COG1399	metal-binding, possibly nucleic acid-binding protein
AL545_RS13630	COG0416	fatty acid biosynthetic process
AL545_RS13635	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AL545_RS13665	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AL545_RS13670	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AL545_RS13675	COG0470	DNA polymerase III
AL545_RS13680	COG0084	hydrolase, TatD family'
AL545_RS13685	COG1263	PTS System
AL545_RS13685	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL545_RS13700	COG0733	neurotransmitter:sodium symporter activity
AL545_RS13715	COG4667	esterase of the alpha-beta hydrolase superfamily
AL545_RS13720	COG0469	pyruvate kinase activity
AL545_RS13725	COG1940	carbohydrate kinase activity
AL545_RS13730	COG0784	Response regulator, receiver
AL545_RS13730	COG0835	chemotaxis
AL545_RS13735	COG0587	DNA-directed DNA polymerase activity
AL545_RS13750	COG1028	Short-chain dehydrogenase reductase Sdr
AL545_RS13755	COG0616	signal peptide processing
AL545_RS13760	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AL545_RS13765	COG0539	negative regulation of cytoplasmic translation
AL545_RS13775	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
AL545_RS13780	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AL545_RS13790	COG4166	transmembrane transport
AL545_RS13810	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AL545_RS13810	COG3008	intermembrane lipid transfer
AL545_RS13815	COG2995	paraquat-inducible protein a
AL545_RS13820	COG3258	Cytochrome c
AL545_RS13825	COG2863	cytochrome
AL545_RS13860	COG4232	protein-disulfide reductase activity
AL545_RS13865	COG3118	belongs to the thioredoxin family
AL545_RS13885	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL545_RS13895	COG1136	(ABC) transporter
AL545_RS13895	COG0577	efflux transmembrane transporter activity
AL545_RS13900	COG1136	(ABC) transporter
AL545_RS13900	COG0577	efflux transmembrane transporter activity
AL545_RS13905	COG0577	efflux transmembrane transporter activity
AL545_RS13905	COG1136	(ABC) transporter
AL545_RS13955	COG5002	protein histidine kinase activity
AL545_RS13955	COG3850	Histidine kinase
AL545_RS13960	COG0745	RESPONSE REGULATOR receiver
AL545_RS13965	COG0463	Glycosyl transferase, family 2
AL545_RS13970	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AL545_RS13990	COG1032	radical SAM domain protein
AL545_RS13995	COG5001	Diguanylate cyclase
AL545_RS14010	COG0583	DNA-binding transcription factor activity
AL545_RS14015	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AL545_RS14025	COG2350	Protein conserved in bacteria
AL545_RS14035	COG2917	probably involved in intracellular septation
AL545_RS14055	COG1301	dicarboxylic acid transport
AL545_RS14065	COG0318	PFAM AMP-dependent synthetase and ligase
AL545_RS14070	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AL545_RS14075	COG0159	tryptophan synthase activity
AL545_RS14085	COG0134	indole-3-glycerol-phosphate synthase activity
AL545_RS14085	COG0135	phosphoribosylanthranilate isomerase activity
AL545_RS14095	COG0512	Glutamine amidotransferase of anthranilate synthase
AL545_RS14100	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AL545_RS14110	COG0613	PHP domain protein
AL545_RS14115	COG0009	L-threonylcarbamoyladenylate synthase
AL545_RS14125	COG1187	pseudouridine synthase activity
AL545_RS14145	COG0417	DNA replication proofreading
AL545_RS14150	COG2197	response regulator
AL545_RS14155	COG0322	excinuclease ABC activity
AL545_RS14195	COG0019	diaminopimelate decarboxylase activity
AL545_RS14225	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AL545_RS14235	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AL545_RS14255	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
AL545_RS14265	COG0437	4 iron, 4 sulfur cluster binding
AL545_RS14270	COG3301	Polysulphide reductase, NrfD
AL545_RS14275	COG1138	Cytochrome C-type biogenesis protein
AL545_RS14285	COG3088	subunit of a heme lyase
AL545_RS14285	COG4235	cytochrome complex assembly
AL545_RS14295	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AL545_RS14320	COG2989	Protein conserved in bacteria
AL545_RS14325	COG3108	Peptidase M15
AL545_RS14330	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AL545_RS14345	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AL545_RS14375	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL545_RS14380	COG0840	transmembrane signaling receptor activity
AL545_RS14400	COG1448	Aminotransferase
AL545_RS14415	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL545_RS14425	COG0017	Asparaginyl-tRNA synthetase
AL545_RS14430	COG0840	transmembrane signaling receptor activity
AL545_RS14435	COG3300	MHYT domain
AL545_RS14435	COG5001	Diguanylate cyclase
AL545_RS14440	COG2205	protein histidine kinase activity
AL545_RS14440	COG0784	Response regulator, receiver
AL545_RS14440	COG5002	protein histidine kinase activity
AL545_RS14450	COG0720	synthase
AL545_RS14460	COG2200	EAL domain
AL545_RS14465	COG1760	l-serine dehydratase
AL545_RS14470	COG0814	amino acid
AL545_RS14475	COG0494	nUDIX hydrolase
AL545_RS14485	COG2205	protein histidine kinase activity
AL545_RS14485	COG0784	Response regulator, receiver
AL545_RS14490	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AL545_RS14510	COG3106	COG3106 Predicted ATPase
AL545_RS14515	COG3768	UPF0283 membrane protein
AL545_RS14525	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL545_RS14570	COG2801	Transposase and inactivated derivatives
AL545_RS14575	COG2026	Addiction module toxin, RelE StbE family
AL545_RS14645	COG1335	isochorismatase
AL545_RS14680	COG2026	Addiction module toxin, RelE StbE family
AL545_RS14700	COG0625	glutathione transferase activity
AL545_RS14945	COG2801	Transposase and inactivated derivatives
AL545_RS14950	COG1357	PFAM Pentapeptide repeats (8 copies)
AL545_RS14965	COG2801	Transposase and inactivated derivatives
AL545_RS14990	COG2801	Transposase and inactivated derivatives
AL545_RS14995	COG2026	Addiction module toxin, RelE StbE family
AL545_RS15220	COG0456	acetyltransferase
AL545_RS15240	COG0456	acetyltransferase
AL545_RS15335	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AL545_RS15355	COG1629	transport
AL545_RS15355	COG4774	siderophore transport
AL545_RS15360	COG2382	esterase
AL545_RS15375	COG1120	ATPase activity
AL545_RS15380	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL545_RS15385	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL545_RS15395	COG4592	Periplasmic binding protein
AL545_RS15400	COG1535	isochorismatase
AL545_RS15400	COG3433	isochorismatase activity
AL545_RS15405	COG1021	2,3-dihydroxybenzoate-AMP ligase
AL545_RS15410	COG1169	isochorismate synthase
AL545_RS15415	COG1028	Short-chain dehydrogenase reductase Sdr
AL545_RS15420	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AL545_RS15510	COG0110	maltose O-acetyltransferase activity
AL545_RS15515	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL545_RS15520	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AL545_RS15540	COG5507	3-demethylubiquinone-9 3-methyltransferase
AL545_RS15545	COG1280	lysine exporter protein (LysE YggA)
AL545_RS15550	COG1280	lysine exporter protein (LysE YggA)
AL545_RS15560	COG0729	surface antigen
AL545_RS15565	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AL545_RS15570	COG2272	Belongs to the type-B carboxylesterase lipase family
AL545_RS15595	COG2985	domain, Protein
AL545_RS15605	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
AL545_RS15620	COG0583	DNA-binding transcription factor activity
AL545_RS15635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL545_RS15650	COG3290	protein histidine kinase activity
AL545_RS15655	COG4565	transcriptional regulatory protein
AL545_RS15665	COG2207	Transcriptional regulator
AL545_RS15670	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AL545_RS15675	COG0363	glucosamine-6-phosphate deaminase activity
AL545_RS15680	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AL545_RS15695	COG3284	Transcriptional regulator
AL545_RS15700	COG1012	belongs to the aldehyde dehydrogenase family
AL545_RS15770	COG4669	(LipO)protein
AL545_RS15790	COG3177	Filamentation induced by cAMP protein fic
AL545_RS15820	COG2207	Transcriptional regulator
AL545_RS15825	COG4792	protein secretion
AL545_RS15830	COG4791	protein targeting
AL545_RS15835	COG4794	Type iii secretion
AL545_RS15840	COG4790	Type iii secretion
AL545_RS15910	COG0457	Tetratricopeptide repeat
AL545_RS15935	COG2358	TRAP transporter, solute receptor (TAXI family
AL545_RS15940	COG0730	response to heat
AL545_RS15975	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AL545_RS15980	COG0372	Belongs to the citrate synthase family
AL545_RS15990	COG2828	Protein conserved in bacteria
AL545_RS16015	COG0561	phosphatase activity
AL545_RS16020	COG0602	queuosine metabolic process
AL545_RS16025	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AL545_RS16040	COG0583	DNA-binding transcription factor activity
AL545_RS16050	COG0583	DNA-binding transcription factor activity
AL545_RS16065	COG0583	DNA-binding transcription factor activity
AL545_RS16080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL545_RS16085	COG0765	amino acid transport
AL545_RS16090	COG1126	abc transporter atp-binding protein
AL545_RS16095	COG0646	methionine synthase
AL545_RS16095	COG1410	methionine synthase
AL545_RS16110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL545_RS16115	COG1335	isochorismatase
AL545_RS16135	COG2814	Major facilitator Superfamily
AL545_RS16140	COG0583	DNA-binding transcription factor activity
AL545_RS16150	COG0583	DNA-binding transcription factor activity
AL545_RS16155	COG0656	L-ascorbic acid biosynthetic process
AL545_RS16165	COG1414	Transcriptional regulator
AL545_RS16170	COG2203	Gaf domain
AL545_RS16170	COG2199	diguanylate cyclase activity
AL545_RS16195	COG2885	chlorophyll binding
AL545_RS16215	COG0840	transmembrane signaling receptor activity
AL545_RS16220	COG1254	Belongs to the acylphosphatase family
AL545_RS16225	COG2920	part of a sulfur-relay system
AL545_RS16235	COG0670	Belongs to the BI1 family
AL545_RS16240	COG1126	abc transporter atp-binding protein
AL545_RS16245	COG0765	amino acid transport
AL545_RS16250	COG4597	amino acid ABC transporter
AL545_RS16255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL545_RS16270	COG1666	GTP binding
AL545_RS16275	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AL545_RS16300	COG3008	intermembrane lipid transfer
AL545_RS16305	COG2995	paraquat-inducible protein a
AL545_RS16310	COG1132	(ABC) transporter
AL545_RS16315	COG1956	GAF domain-containing protein
AL545_RS16320	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
AL545_RS16335	COG0308	aminopeptidase N
AL545_RS16345	COG2902	Dehydrogenase
AL545_RS16350	COG0167	dihydroorotate dehydrogenase activity
AL545_RS16360	COG0116	Belongs to the methyltransferase superfamily
AL545_RS16360	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AL545_RS16370	COG0488	(ABC) transporter
AL545_RS16385	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AL545_RS16390	COG1067	ATP-dependent peptidase activity
AL545_RS16395	COG3120	sequence-specific DNA binding
AL545_RS16430	COG4128	Pfam Zonular occludens toxin
AL545_RS16565	COG4128	Pfam Zonular occludens toxin
AL545_RS16635	COG4128	Pfam Zonular occludens toxin
AL545_RS16685	COG0784	Response regulator, receiver
AL545_RS16685	COG2205	protein histidine kinase activity
AL545_RS16700	COG3278	Belongs to the heme-copper respiratory oxidase family
AL545_RS16715	COG2010	Cytochrome c
AL545_RS16725	COG2217	Heavy metal translocating P-type atpase
AL545_RS16740	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AL545_RS16745	COG0589	response to stress
AL545_RS16775	COG3842	ATPase activity
AL545_RS16785	COG1177	transmembrane transport
AL545_RS16795	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AL545_RS16800	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AL545_RS16805	COG0004	ammonium transporteR
AL545_RS16835	COG0437	4 iron, 4 sulfur cluster binding
AL545_RS16840	COG3383	formate dehydrogenase (NAD+) activity
AL545_RS16840	COG0243	molybdopterin cofactor binding
AL545_RS16850	COG3381	protein complex oligomerization
AL545_RS16870	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AL545_RS16875	COG0488	(ABC) transporter
AL545_RS16885	COG3852	Histidine kinase
AL545_RS16890	COG2204	response regulator
AL545_RS16905	COG3842	ATPase activity
AL545_RS16910	COG0746	molybdenum cofactor guanylyltransferase activity
AL545_RS16915	COG0303	'Molybdopterin
AL545_RS16925	COG1940	carbohydrate kinase activity
AL545_RS16930	COG3148	PFAM DTW domain containing protein
AL545_RS16960	COG0791	NLP P60 protein
AL545_RS16970	COG3706	GGDEF domain
AL545_RS16980	COG3001	Fructosamine kinase
AL545_RS16990	COG0307	riboflavin synthase, alpha
AL545_RS16995	COG0534	Mate efflux family protein
AL545_RS17005	COG1793	dna ligase
AL545_RS17035	COG2204	response regulator
AL545_RS17040	COG0297	glycogen (starch) synthase activity
AL545_RS17045	COG0438	transferase activity, transferring glycosyl groups
AL545_RS17075	COG0438	transferase activity, transferring glycosyl groups
AL545_RS17080	COG1215	transferase activity, transferring glycosyl groups
AL545_RS17085	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AL545_RS17095	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL545_RS17110	COG1643	Atp-dependent helicase
AL545_RS17115	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AL545_RS17160	COG0443	Heat shock 70 kDa protein
AL545_RS17165	COG0443	Heat shock 70 kDa protein
AL545_RS17190	COG0583	DNA-binding transcription factor activity
AL545_RS17205	COG1132	(ABC) transporter
AL545_RS17210	COG1132	(ABC) transporter
AL545_RS17220	COG4774	siderophore transport
AL545_RS17230	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AL545_RS17235	COG1120	ATPase activity
AL545_RS17250	COG0814	amino acid
AL545_RS17260	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AL545_RS17270	COG0861	Integral membrane protein TerC family
AL545_RS17280	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AL545_RS17285	COG1328	CTP reductase activity
AL545_RS17300	COG5001	Diguanylate cyclase
AL545_RS17300	COG3300	MHYT domain
AL545_RS17315	COG0471	metal ion transport
AL545_RS17340	COG4702	Belongs to the UPF0303 family
AL545_RS17345	COG0673	inositol 2-dehydrogenase activity
AL545_RS17350	COG1349	DNA-binding transcription factor activity
AL545_RS17365	COG1538	Outer membrane efflux protein
AL545_RS17390	COG3119	arylsulfatase activity
AL545_RS17405	COG0641	radical SAM
AL545_RS17420	COG3119	arylsulfatase activity
AL545_RS17430	COG0527	aspartate kinase activity
AL545_RS17435	COG0662	Cupin 2, conserved barrel domain protein
AL545_RS17440	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AL545_RS17445	COG0456	acetyltransferase
AL545_RS17450	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL545_RS17465	COG4175	Glycine betaine
AL545_RS17470	COG4176	ABC-type proline glycine betaine transport system permease component
AL545_RS17475	COG2113	Glycine betaine
AL545_RS17480	COG1368	sulfuric ester hydrolase activity
AL545_RS17505	COG1115	amino acid carrier protein
AL545_RS17515	COG1280	lysine exporter protein (LysE YggA)
AL545_RS17520	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AL545_RS17525	COG1560	Kdo2-lipid A biosynthetic process
AL545_RS17540	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
AL545_RS17545	COG3063	Type IV pilus biogenesis stability protein PilW
AL545_RS17585	COG2315	Protein conserved in bacteria
AL545_RS17590	COG1846	Transcriptional regulator
AL545_RS17600	COG2200	EAL domain
AL545_RS17605	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AL545_RS17610	COG1012	belongs to the aldehyde dehydrogenase family
AL545_RS17615	COG2957	Belongs to the agmatine deiminase family
AL545_RS17625	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AL545_RS17630	COG1012	belongs to the aldehyde dehydrogenase family
AL545_RS17635	COG1917	Cupin 2, conserved barrel domain protein
AL545_RS17635	COG1396	sequence-specific DNA binding
AL545_RS17640	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AL545_RS17650	COG0174	glutamine synthetase
AL545_RS17655	COG1757	Na H antiporter
AL545_RS17670	COG1742	UPF0060 membrane protein
AL545_RS17695	COG3755	Protein conserved in bacteria
AL545_RS17745	COG0625	glutathione transferase activity
AL545_RS17755	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
AL545_RS17765	COG2195	Cleaves the N-terminal amino acid of tripeptides
AL545_RS17775	COG0601	transmembrane transport
AL545_RS17780	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL545_RS17800	COG3291	Pkd domain containing protein
AL545_RS17810	COG1177	transmembrane transport
AL545_RS17815	COG1176	ABC-type spermidine putrescine transport system, permease component I
AL545_RS17820	COG3842	ATPase activity
AL545_RS17825	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AL545_RS17830	COG2423	ornithine cyclodeaminase activity
AL545_RS17845	COG3938	Belongs to the proline racemase family
AL545_RS17875	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
AL545_RS17880	COG1451	nucleotide metabolic process
AL545_RS17890	COG0583	DNA-binding transcription factor activity
AL545_RS17910	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
AL545_RS17915	COG4139	cobalamin transport
AL545_RS17920	COG2988	succinylglutamate desuccinylase activity
AL545_RS17940	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AL545_RS17945	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AL545_RS17950	COG0702	epimerase
AL545_RS17955	COG1823	symporter activity
AL545_RS17960	COG2925	Exonuclease
AL545_RS17965	COG1380	Effector of murein hydrolase LrgA
AL545_RS17970	COG1346	cytolysis
AL545_RS17975	COG0295	cytidine deaminase activity
AL545_RS17980	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AL545_RS17985	COG0500	methyltransferase
AL545_RS17995	COG0776	regulation of translation
AL545_RS18005	COG0072	phenylalanine-tRNA ligase activity
AL545_RS18005	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL545_RS18010	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AL545_RS18045	COG0393	Putative heavy-metal-binding
AL545_RS18055	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AL545_RS18065	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AL545_RS18080	COG2188	Transcriptional regulator
AL545_RS18085	COG1228	amidohydrolase
AL545_RS18090	COG0010	Belongs to the arginase family
AL545_RS18095	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AL545_RS18100	COG2986	histidine ammonia-lyase
AL545_RS18115	COG0247	lactate metabolic process
AL545_RS18115	COG0277	FAD linked oxidase domain protein
AL545_RS18150	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AL545_RS18165	COG1643	Atp-dependent helicase
AL545_RS18170	COG0281	malic enzyme
AL545_RS18175	COG2949	membrane
AL545_RS18180	COG0471	metal ion transport
AL545_RS18205	COG0492	ferredoxin-NADP+ reductase activity
AL545_RS18210	COG4988	ABC transporter
AL545_RS18215	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AL545_RS18225	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AL545_RS18235	COG4191	Histidine kinase
AL545_RS18235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL545_RS18250	COG3070	regulator of competence-specific genes
AL545_RS18270	COG2431	L-lysine efflux transmembrane transporter activity
AL545_RS18280	COG0076	glutamate decarboxylase activity
AL545_RS18285	COG1737	Transcriptional regulator
AL545_RS18300	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AL545_RS18305	COG2985	domain, Protein
AL545_RS18305	COG3273	potassium ion transport
AL545_RS18310	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AL545_RS18315	COG1960	acyl-CoA dehydrogenase activity
AL545_RS18325	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AL545_RS18345	COG0534	Mate efflux family protein
AL545_RS18350	COG0702	epimerase
AL545_RS18360	COG2814	Major facilitator Superfamily
AL545_RS18370	COG1187	pseudouridine synthase activity
AL545_RS18375	COG1061	Type III restriction enzyme res subunit
AL545_RS18395	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AL545_RS18420	COG3313	Fe-S protein
AL545_RS18430	COG4134	Bacterial extracellular solute-binding protein
AL545_RS18435	COG4135	transport system, permease component
AL545_RS18440	COG4136	ATPase activity
AL545_RS18445	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AL545_RS18460	COG3604	Transcriptional regulator
AL545_RS18465	COG1151	hydroxylamine reductase activity
AL545_RS18470	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AL545_RS18475	COG0116	Belongs to the methyltransferase superfamily
AL545_RS18475	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AL545_RS18480	COG0564	pseudouridine synthase activity
AL545_RS18485	COG0733	neurotransmitter:sodium symporter activity
AL545_RS18495	COG0626	cystathionine gamma-synthase activity
AL545_RS18500	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
AL545_RS18505	COG5380	lipid catabolic process
AL545_RS18510	COG2818	Glycosylase
AL545_RS18530	COG1983	PspC domain protein
AL545_RS18540	COG1842	Phage shock protein A
AL545_RS18545	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AL545_RS18560	COG4171	peptide transport system, permease
AL545_RS18570	COG4172	Belongs to the ABC transporter superfamily
AL545_RS18580	COG1227	inorganic diphosphatase activity
AL545_RS18595	COG0243	molybdopterin cofactor binding
AL545_RS18600	COG3005	denitrification pathway
AL545_RS18605	COG4459	periplasmic nitrate reductase
AL545_RS18610	COG0390	transport system, permease component
AL545_RS18620	COG2116	formate transmembrane transporter activity
AL545_RS18650	COG1435	thymidine kinase activity
AL545_RS18655	COG0215	cysteine-tRNA ligase activity
AL545_RS18660	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AL545_RS18665	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AL545_RS18670	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AL545_RS18675	COG3012	SEC-C Motif Domain Protein
AL545_RS18680	COG0140	phosphoribosyl-ATP diphosphatase activity
AL545_RS18680	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AL545_RS18690	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AL545_RS18695	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AL545_RS18700	COG0131	Imidazoleglycerol-phosphate dehydratase
AL545_RS18700	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AL545_RS18710	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AL545_RS18725	COG1757	Na H antiporter
AL545_RS18735	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL545_RS18750	COG2915	High frequency lysogenization protein hflD homolog
AL545_RS18755	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AL545_RS18765	COG2268	Band 7 protein
AL545_RS18775	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AL545_RS18790	COG0300	oxidoreductase activity
AL545_RS18810	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AL545_RS18835	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AL545_RS18845	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AL545_RS18855	COG1674	ftsk spoiiie
AL545_RS18865	COG0686	Belongs to the AlaDH PNT family
AL545_RS18875	COG0583	DNA-binding transcription factor activity
AL545_RS18900	COG3568	Endonuclease Exonuclease Phosphatase
AL545_RS18925	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL545_RS18930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL545_RS18950	COG1271	oxidase subunit
AL545_RS18955	COG1294	oxidase, subunit
AL545_RS18985	COG0784	Response regulator, receiver
AL545_RS18985	COG5002	protein histidine kinase activity
AL545_RS18995	COG0754	glutathionylspermidine amidase activity
AL545_RS19005	COG3766	membrane
AL545_RS19015	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AL545_RS19020	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
AL545_RS19025	COG2885	chlorophyll binding
AL545_RS19030	COG0823	Involved in the tonB-independent uptake of proteins
AL545_RS19045	COG0811	peptide transport
AL545_RS19050	COG0824	Thioesterase
AL545_RS19060	COG4890	Cyd operon protein YbgT
AL545_RS19065	COG1294	oxidase, subunit
AL545_RS19070	COG1271	oxidase subunit
AL545_RS19075	COG2255	four-way junction helicase activity
AL545_RS19080	COG0632	four-way junction helicase activity
AL545_RS19085	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AL545_RS19090	COG0217	transcriptional regulatory protein
AL545_RS19100	COG1801	Protein of unknown function DUF72
AL545_RS19110	COG0500	methyltransferase
AL545_RS19120	COG0189	ligase activity
AL545_RS19120	COG4067	protein conserved in archaea
AL545_RS19140	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AL545_RS19145	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
AL545_RS19155	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AL545_RS19160	COG1434	Gram-negative-bacterium-type cell wall biogenesis
AL545_RS19165	COG0745	RESPONSE REGULATOR receiver
AL545_RS19170	COG3381	protein complex oligomerization
AL545_RS19175	COG1609	Transcriptional regulator
AL545_RS19180	COG3070	regulator of competence-specific genes
AL545_RS19200	COG0297	glycogen (starch) synthase activity
AL545_RS19205	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AL545_RS19210	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AL545_RS19230	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AL545_RS19235	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AL545_RS19240	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AL545_RS19245	COG0542	response to heat
AL545_RS19250	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AL545_RS19255	COG1278	Cold shock
AL545_RS19265	COG1187	pseudouridine synthase activity
AL545_RS19270	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
AL545_RS19275	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AL545_RS19280	COG1199	ATP-dependent helicase activity
AL545_RS19285	COG0730	response to heat
AL545_RS19290	COG3923	Primosomal replication protein n
AL545_RS19300	COG0708	Exodeoxyribonuclease III
AL545_RS19345	COG1882	Formate acetyltransferase
AL545_RS19355	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AL545_RS19365	COG3013	Belongs to the UPF0304 family
AL545_RS19375	COG2766	serine protein kinase
AL545_RS19380	COG2718	Belongs to the UPF0229 family
AL545_RS19385	COG2719	SpoVR family
AL545_RS19405	COG1132	(ABC) transporter
AL545_RS19410	COG0658	competence protein
AL545_RS19410	COG2333	competence protein COMEC
AL545_RS19420	COG4591	ABC-type transport system involved in lipoprotein release permease component
AL545_RS19425	COG1136	(ABC) transporter
AL545_RS19430	COG4591	ABC-type transport system involved in lipoprotein release permease component
AL545_RS19440	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AL545_RS19455	COG1252	NADH dehydrogenase
AL545_RS19460	COG3150	esterase
AL545_RS19485	COG0537	adenosine 5'-monophosphoramidase activity
AL545_RS19510	COG0517	IMP dehydrogenase activity
AL545_RS19510	COG0516	GMP reductase activity
AL545_RS19515	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AL545_RS19540	COG3126	Type III secretion system lipoprotein chaperone (YscW)
AL545_RS19545	COG1946	Acyl-CoA thioesterase
AL545_RS19555	COG1522	sequence-specific DNA binding
AL545_RS19560	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AL545_RS19575	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL545_RS19580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL545_RS19625	COG0477	Major facilitator Superfamily
AL545_RS19630	COG2855	membrane
AL545_RS19650	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AL545_RS19665	COG1169	isochorismate synthase
AL545_RS19670	COG0436	Aminotransferase
AL545_RS19675	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
AL545_RS19680	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AL545_RS19695	COG1555	photosystem II stabilization
AL545_RS19700	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AL545_RS19705	COG0776	regulation of translation
AL545_RS19710	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AL545_RS19715	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AL545_RS19725	COG0544	peptidyl-prolyl cis-trans isomerase activity
AL545_RS19750	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AL545_RS19755	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AL545_RS19760	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AL545_RS19765	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AL545_RS19780	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AL545_RS19785	COG0569	domain protein
AL545_RS19790	COG0513	Belongs to the DEAD box helicase family
AL545_RS19825	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AL545_RS19830	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AL545_RS19845	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AL545_RS19850	COG1216	Glycosyl transferase, family 2
AL545_RS19855	COG2986	histidine ammonia-lyase
AL545_RS19880	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AL545_RS19890	COG1028	Short-chain dehydrogenase reductase Sdr
AL545_RS19905	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AL545_RS19910	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AL545_RS19920	COG2951	lytic endotransglycosylase activity
AL545_RS19925	COG3100	YcgL domain-containing protein
AL545_RS19930	COG0850	regulation of cytokinetic process
AL545_RS19935	COG2894	cell division
AL545_RS19940	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AL545_RS19945	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AL545_RS19950	COG0318	PFAM AMP-dependent synthetase and ligase
AL545_RS19955	COG2267	carboxylic ester hydrolase activity
AL545_RS19960	COG3065	identical protein binding
AL545_RS19970	COG1214	PFAM Peptidase M22, glycoprotease
AL545_RS19975	COG1199	ATP-dependent helicase activity
AL545_RS19980	COG0788	formyltetrahydrofolate deformylase activity
AL545_RS19995	COG3102	Protein conserved in bacteria
AL545_RS20005	COG0018	arginyl-trna synthetase
AL545_RS20030	COG1918	ferrous iron import across plasma membrane
AL545_RS20035	COG4977	sequence-specific DNA binding
AL545_RS20040	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
AL545_RS20045	COG1121	(ABC) transporter
AL545_RS20050	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AL545_RS20060	COG0045	succinate-CoA ligase (ADP-forming) activity
AL545_RS20065	COG0508	dehydrogenase complex catalyzes the overall conversion of
AL545_RS20070	COG0567	Dehydrogenase, E1 component
AL545_RS20075	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AL545_RS20080	COG1053	succinate dehydrogenase
AL545_RS20085	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AL545_RS20100	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AL545_RS20110	COG0033	Phosphoglucomutase
AL545_RS20115	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
AL545_RS20120	COG0596	Alpha beta hydrolase
AL545_RS20130	COG0716	FMN binding
AL545_RS20140	COG0735	belongs to the Fur family
AL545_RS20145	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AL545_RS20150	COG1263	PTS System
AL545_RS20150	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL545_RS20150	COG2190	(PTS) system
AL545_RS20160	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AL545_RS20165	COG1940	carbohydrate kinase activity
AL545_RS20165	COG1846	Transcriptional regulator
AL545_RS20170	COG4651	solute:proton antiporter activity
AL545_RS20170	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AL545_RS20175	COG0367	asparagine synthase
AL545_RS20180	COG0250	Participates in transcription elongation, termination and antitermination
AL545_RS20185	COG3104	oligopeptide transport
AL545_RS20190	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AL545_RS20200	COG0326	Molecular chaperone. Has ATPase activity
AL545_RS20205	COG3710	Transcriptional regulator
AL545_RS20225	COG0622	Phosphoesterase
AL545_RS20255	COG1090	epimerase
AL545_RS20260	COG0300	oxidoreductase activity
AL545_RS20270	COG3118	belongs to the thioredoxin family
AL545_RS20280	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
AL545_RS20285	COG1215	transferase activity, transferring glycosyl groups
AL545_RS20290	COG1215	transferase activity, transferring glycosyl groups
AL545_RS20295	COG1192	Involved in chromosome partitioning
AL545_RS20310	COG2194	sulfuric ester hydrolase activity
AL545_RS20315	COG0330	HflC and HflK could
AL545_RS20340	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AL545_RS20345	COG3115	cell septum assembly
AL545_RS20350	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
AL545_RS20355	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AL545_RS20365	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL545_RS20370	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AL545_RS20375	COG2190	(PTS) system
AL545_RS20380	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL545_RS20385	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL545_RS20390	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL545_RS20395	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL545_RS20405	COG1705	Flagellar rod assembly protein muramidase FlgJ
AL545_RS20405	COG3951	Flagellar rod assembly protein muramidase FlgJ
AL545_RS20410	COG1706	bacterial-type flagellum-dependent cell motility
AL545_RS20415	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AL545_RS20425	COG4787	bacterial-type flagellum-dependent cell motility
AL545_RS20430	COG1749	Flagellar hook protein flgE
AL545_RS20440	COG1558	bacterial-type flagellum-dependent cell motility
AL545_RS20445	COG1815	bacterial-type flagellum-dependent cell motility
AL545_RS20450	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AL545_RS20455	COG0835	chemotaxis
AL545_RS20455	COG0784	Response regulator, receiver
AL545_RS20510	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
AL545_RS20525	COG2608	mercury ion transmembrane transporter activity
AL545_RS20525	COG2217	Heavy metal translocating P-type atpase
AL545_RS20565	COG2840	Smr protein MutS2
AL545_RS20570	COG1187	pseudouridine synthase activity
AL545_RS20575	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AL545_RS20580	COG0737	Belongs to the 5'-nucleotidase family
AL545_RS20585	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AL545_RS20590	COG2912	Transglutaminase-like superfamily
AL545_RS20595	COG3094	Invasion gene expression up-regulator, SirB
AL545_RS20600	COG2890	protein-(glutamine-N5) methyltransferase activity
AL545_RS20610	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AL545_RS20615	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AL545_RS20620	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AL545_RS20625	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AL545_RS20630	COG0193	aminoacyl-tRNA hydrolase activity
AL545_RS20635	COG0012	GTP binding
AL545_RS20745	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AL545_RS20755	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AL545_RS20760	COG1702	phosphate starvation-inducible protein PhoH
AL545_RS20765	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AL545_RS20770	COG4535	Mg2 and Co2 transporter CorC
AL545_RS20775	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AL545_RS20780	COG2888	peptidyl-tyrosine sulfation
AL545_RS20785	COG0495	leucyl-tRNA aminoacylation
AL545_RS20790	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
AL545_RS20795	COG1466	dna polymerase III delta subunit
AL545_RS20800	COG0799	negative regulation of ribosome biogenesis
AL545_RS20805	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AL545_RS20810	COG0768	penicillin binding
AL545_RS20815	COG0772	Belongs to the SEDS family
AL545_RS20820	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AL545_RS20825	COG1686	Belongs to the peptidase S11 family
AL545_RS20835	COG0321	lipoyl(octanoyl) transferase activity
AL545_RS20840	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AL545_RS20845	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AL545_RS20850	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AL545_RS20865	COG0366	Alpha amylase catalytic
AL545_RS20870	COG1263	PTS System
AL545_RS20870	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL545_RS20880	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AL545_RS20885	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AL545_RS20890	COG2011	ABC-type metal ion transport system permease component
AL545_RS20895	COG1464	Belongs to the NlpA lipoprotein family
AL545_RS20900	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
AL545_RS20910	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AL545_RS20910	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AL545_RS20925	COG1611	Belongs to the LOG family
AL545_RS20930	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL545_RS20945	COG2363	Small membrane protein
AL545_RS20955	COG0583	DNA-binding transcription factor activity
AL545_RS20960	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AL545_RS20960	COG0301	tRNA thio-modification
AL545_RS20970	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AL545_RS20975	COG1722	exodeoxyribonuclease VII activity
AL545_RS20980	COG0142	geranyltranstransferase activity
AL545_RS20985	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AL545_RS20990	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AL545_RS20995	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AL545_RS21005	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AL545_RS21020	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AL545_RS21020	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AL545_RS21025	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AL545_RS21030	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AL545_RS21035	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AL545_RS21045	COG1073	alpha beta
AL545_RS21050	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
AL545_RS21055	COG2252	PERMEase
AL545_RS21060	COG2195	Cleaves the N-terminal amino acid of tripeptides
AL545_RS21090	COG0047	phosphoribosylformylglycinamidine synthase activity
AL545_RS21090	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AL545_RS21095	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AL545_RS21110	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AL545_RS21145	COG0484	heat shock protein binding
AL545_RS21155	COG1301	dicarboxylic acid transport
AL545_RS21160	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AL545_RS21165	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AL545_RS21175	COG0497	DNA recombination
AL545_RS21185	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL545_RS21190	COG2914	Belongs to the UPF0125 (RnfH) family
AL545_RS21195	COG2867	negative regulation of translational initiation
AL545_RS21200	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AL545_RS21215	COG0328	RNA-DNA hybrid ribonuclease activity
AL545_RS21260	COG0583	DNA-binding transcription factor activity
AL545_RS21265	COG3153	acetyltransferase
AL545_RS21265	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AL545_RS21285	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AL545_RS21290	COG2873	o-acetylhomoserine
AL545_RS21305	COG1115	amino acid carrier protein
AL545_RS21310	COG1584	GPR1 FUN34 yaaH family protein
AL545_RS21320	COG1757	Na H antiporter
AL545_RS21325	COG0519	Catalyzes the synthesis of GMP from XMP
AL545_RS21325	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AL545_RS21330	COG0517	IMP dehydrogenase activity
AL545_RS21330	COG0516	GMP reductase activity
AL545_RS21350	COG1160	GTP binding
AL545_RS21355	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL545_RS21360	COG2976	Protein conserved in bacteria
AL545_RS21365	COG0124	histidyl-tRNA synthetase
AL545_RS21370	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AL545_RS21385	COG0105	UTP biosynthetic process
AL545_RS21395	COG2975	iron-sulfur cluster assembly
AL545_RS21400	COG0633	Ferredoxin
AL545_RS21405	COG0443	Heat shock 70 kDa protein
AL545_RS21420	COG0822	iron-sulfur transferase activity
AL545_RS21435	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
AL545_RS21440	COG0483	inositol monophosphate 1-phosphatase activity
AL545_RS21455	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL545_RS21460	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL545_RS21465	COG1862	Preprotein translocase
AL545_RS21475	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AL545_RS21485	COG0517	IMP dehydrogenase activity
AL545_RS21495	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AL545_RS21500	COG0583	DNA-binding transcription factor activity
AL545_RS21505	COG0450	alkyl hydroperoxide reductase
AL545_RS21510	COG3142	Participates in the control of copper homeostasis
AL545_RS21520	COG0704	Plays a role in the regulation of phosphate uptake
AL545_RS21525	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AL545_RS21530	COG0581	inorganic phosphate transmembrane transporter activity
AL545_RS21535	COG0573	inorganic phosphate transmembrane transporter activity
AL545_RS21540	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AL545_RS21545	COG0248	Ppx GppA phosphatase
AL545_RS21560	COG5002	protein histidine kinase activity
AL545_RS21565	COG0745	RESPONSE REGULATOR receiver
AL545_RS21575	COG2974	May be involved in recombination
AL545_RS21580	COG0826	peptidase U32
AL545_RS21585	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AL545_RS21650	COG0542	response to heat
AL545_RS21660	COG0564	pseudouridine synthase activity
AL545_RS21665	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL545_RS21670	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AL545_RS21675	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AL545_RS21685	COG0077	Prephenate dehydratase
AL545_RS21685	COG1605	Chorismate mutase
AL545_RS21690	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
AL545_RS21695	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
AL545_RS21705	COG0488	(ABC) transporter
AL545_RS21715	COG0739	heme binding
AL545_RS21720	COG0287	Prephenate dehydrogenase
AL545_RS21720	COG1605	Chorismate mutase
AL545_RS21725	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AL545_RS21730	COG1472	Belongs to the glycosyl hydrolase 3 family
AL545_RS21735	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AL545_RS21755	COG1966	Carbon starvation protein
AL545_RS21760	COG3275	phosphorelay sensor kinase activity
AL545_RS21765	COG3279	Response regulator of the LytR AlgR family
AL545_RS21775	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AL545_RS21780	COG1047	Peptidyl-prolyl cis-trans
AL545_RS21795	COG0196	riboflavin kinase activity
AL545_RS21800	COG0728	peptidoglycan biosynthetic process
AL545_RS21805	COG0268	Binds directly to 16S ribosomal RNA
AL545_RS21810	COG0640	Transcriptional regulator
AL545_RS21815	COG0583	DNA-binding transcription factor activity
AL545_RS21820	COG1283	sodium-dependent phosphate transmembrane transporter activity
AL545_RS21830	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AL545_RS21835	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AL545_RS21840	COG0730	response to heat
AL545_RS21865	COG0667	Aldo Keto reductase
AL545_RS21875	COG2204	response regulator
AL545_RS21890	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AL545_RS21895	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AL545_RS21900	COG4974	Belongs to the 'phage' integrase family
AL545_RS21905	COG0716	FMN binding
AL545_RS21915	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AL545_RS21920	COG0513	Belongs to the DEAD box helicase family
AL545_RS21925	COG3022	response to hydroperoxide
AL545_RS21930	COG1115	amino acid carrier protein
AL545_RS21945	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AL545_RS21955	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AL545_RS21960	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
AL545_RS21970	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AL545_RS21975	COG0083	homoserine kinase activity
AL545_RS21995	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AL545_RS22010	COG0745	RESPONSE REGULATOR receiver
AL545_RS22020	COG2198	Histidine kinase
AL545_RS22020	COG5002	protein histidine kinase activity
AL545_RS22020	COG0784	Response regulator, receiver
AL545_RS22025	COG2203	Gaf domain
AL545_RS22025	COG4251	negative regulation of phosphorylation
AL545_RS22025	COG5001	Diguanylate cyclase
AL545_RS22025	COG3706	GGDEF domain
AL545_RS22030	COG1242	4 iron, 4 sulfur cluster binding
AL545_RS22035	COG0070	glutamate synthase
AL545_RS22035	COG0069	glutamate synthase activity
AL545_RS22035	COG0067	glutamate synthase
AL545_RS22045	COG0070	glutamate synthase
AL545_RS22045	COG0069	glutamate synthase activity
AL545_RS22045	COG0067	glutamate synthase
AL545_RS22050	COG0493	'glutamate synthase
AL545_RS22060	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AL545_RS22075	COG2860	membrane
AL545_RS22080	COG0583	DNA-binding transcription factor activity
AL545_RS22085	COG0730	response to heat
AL545_RS22100	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AL545_RS22105	COG0505	Belongs to the CarA family
AL545_RS22115	COG0494	nUDIX hydrolase
AL545_RS22120	COG0653	protein targeting
AL545_RS22130	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AL545_RS22135	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AL545_RS22140	COG0849	cell division
AL545_RS22145	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AL545_RS22160	COG0772	Belongs to the SEDS family
AL545_RS22165	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AL545_RS22170	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AL545_RS22175	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AL545_RS22180	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AL545_RS22185	COG0768	penicillin binding
AL545_RS22190	COG3116	cell division
AL545_RS22210	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AL545_RS22225	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AL545_RS22230	COG2823	Periplasmic or secreted lipoprotein
AL545_RS22235	COG2969	positive regulation of protein catabolic process
AL545_RS22240	COG0625	glutathione transferase activity
AL545_RS22245	COG2857	Cytochrome c1
AL545_RS22250	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AL545_RS22255	COG0723	plastoquinol--plastocyanin reductase activity
AL545_RS22260	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AL545_RS22275	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AL545_RS22285	COG3105	Protein conserved in bacteria
AL545_RS22295	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AL545_RS22300	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AL545_RS22310	COG3150	esterase
AL545_RS22320	COG3151	Protein conserved in bacteria
AL545_RS22325	COG0494	nUDIX hydrolase
AL545_RS22330	COG1538	Outer membrane efflux protein
AL545_RS22335	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AL545_RS22335	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AL545_RS22340	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AL545_RS22355	COG3025	triphosphatase activity
AL545_RS22360	COG1392	Phosphate transport regulator
AL545_RS22365	COG0306	phosphate transporter
AL545_RS22370	COG4991	sh3 domain protein
AL545_RS22375	COG0405	Gamma-glutamyltransferase
AL545_RS22385	COG3409	Peptidoglycan-binding domain 1 protein
AL545_RS22385	COG3267	Type II secretory pathway component ExeA
AL545_RS22395	COG1968	undecaprenyl-diphosphatase activity
AL545_RS22400	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AL545_RS22405	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AL545_RS22410	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AL545_RS22415	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AL545_RS22420	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AL545_RS22425	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AL545_RS22430	COG1610	YqeY-like protein
AL545_RS22435	COG0358	DNA primase activity
AL545_RS22450	COG1464	Belongs to the NlpA lipoprotein family
AL545_RS22470	COG2213	PTS system mannitol-specific
AL545_RS22470	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL545_RS22480	COG3722	fumarate hydratase activity
AL545_RS22495	COG1461	Dihydroxyacetone kinase
AL545_RS22500	COG2376	Dihydroxyacetone kinase
AL545_RS22510	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AL545_RS22515	COG1349	DNA-binding transcription factor activity
AL545_RS22520	COG0469	pyruvate kinase activity
AL545_RS22535	COG0440	acetolactate synthase activity
AL545_RS22540	COG0028	Belongs to the TPP enzyme family
AL545_RS22545	COG1022	Amp-dependent synthetase and ligase
AL545_RS22550	COG0583	DNA-binding transcription factor activity
AL545_RS22575	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AL545_RS22580	COG0473	3-isopropylmalate dehydrogenase activity
AL545_RS22600	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AL545_RS22605	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AL545_RS22610	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AL545_RS22615	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AL545_RS22620	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AL545_RS22625	COG2967	ApaG domain
AL545_RS22630	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AL545_RS22635	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AL545_RS22645	COG2966	Psort location CytoplasmicMembrane, score
AL545_RS22650	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AL545_RS22660	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AL545_RS22665	COG0142	geranyltranstransferase activity
AL545_RS22690	COG2358	TRAP transporter, solute receptor (TAXI family
AL545_RS22710	COG1902	pentaerythritol trinitrate reductase activity
AL545_RS22715	COG0583	DNA-binding transcription factor activity
AL545_RS22720	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
AL545_RS22725	COG1178	ABC-type Fe3 transport system permease component
AL545_RS22730	COG4143	(ABC) transporter
AL545_RS22735	COG0163	prenyltransferase activity
AL545_RS22740	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AL545_RS22750	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AL545_RS22755	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AL545_RS22765	COG2105	PFAM AIG2 family protein
AL545_RS22770	COG2911	Protein conserved in bacteria
AL545_RS22775	COG0729	surface antigen
AL545_RS22780	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL545_RS22790	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
AL545_RS22805	COG4181	ATPase activity
AL545_RS22825	COG0529	Catalyzes the synthesis of activated sulfate
AL545_RS22830	COG0471	metal ion transport
AL545_RS22830	COG3273	potassium ion transport
AL545_RS22835	COG2895	sulfate adenylyltransferase (ATP) activity
AL545_RS22840	COG0175	sulfate reduction
AL545_RS22845	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AL545_RS22845	COG1648	precorrin-2 dehydrogenase activity
AL545_RS22860	COG0513	Belongs to the DEAD box helicase family
AL545_RS22865	COG2153	protein acetylation
AL545_RS22875	COG0545	Peptidyl-prolyl cis-trans isomerase
AL545_RS22885	COG0203	ribosomal protein L17
AL545_RS22890	COG0202	RNA polymerase activity
AL545_RS22900	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AL545_RS22905	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AL545_RS22910	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AL545_RS22915	COG0201	protein transport
AL545_RS22920	COG0200	Binds to the 23S rRNA
AL545_RS22925	COG1841	ribosomal large subunit assembly
AL545_RS22940	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AL545_RS22945	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AL545_RS22955	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AL545_RS22960	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AL545_RS22970	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AL545_RS22975	COG0255	Belongs to the universal ribosomal protein uL29 family
AL545_RS22985	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AL545_RS22990	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AL545_RS22995	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AL545_RS23000	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AL545_RS23010	COG0088	Forms part of the polypeptide exit tunnel
AL545_RS23015	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AL545_RS23025	COG0254	rRNA binding
AL545_RS23035	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AL545_RS23040	COG1609	Transcriptional regulator
AL545_RS23050	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AL545_RS23055	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AL545_RS23060	COG1575	Belongs to the MenA family. Type 1 subfamily
AL545_RS23065	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AL545_RS23075	COG1494	fructose-1,6-bisphosphatase
AL545_RS23095	COG3152	Membrane
AL545_RS23105	COG0149	triose-phosphate isomerase activity
AL545_RS23140	COG0438	transferase activity, transferring glycosyl groups
AL545_RS23160	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AL545_RS23170	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AL545_RS23180	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AL545_RS23205	COG0438	transferase activity, transferring glycosyl groups
AL545_RS23220	COG2244	polysaccharide biosynthetic process
AL545_RS23255	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL545_RS23265	COG1560	Kdo2-lipid A biosynthetic process
AL545_RS23275	COG0859	PFAM glycosyl transferase family 9
AL545_RS23280	COG1519	Transferase
AL545_RS23285	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AL545_RS23325	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AL545_RS23335	COG3642	lipopolysaccharide core region biosynthetic process
AL545_RS23340	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AL545_RS23345	COG0859	PFAM glycosyl transferase family 9
AL545_RS23350	COG0463	Glycosyl transferase, family 2
AL545_RS23365	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AL545_RS23390	COG2003	Belongs to the UPF0758 family
AL545_RS23405	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AL545_RS23410	COG1309	transcriptional regulator
AL545_RS23415	COG1560	Kdo2-lipid A biosynthetic process
AL545_RS23420	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AL545_RS23425	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AL545_RS23435	COG1561	YicC-like family, N-terminal region
AL545_RS23445	COG4608	Belongs to the ABC transporter superfamily
AL545_RS23450	COG0444	Belongs to the ABC transporter superfamily
AL545_RS23455	COG0747	negative chemotaxis
AL545_RS23460	COG4239	(ABC) transporter, permease
AL545_RS23465	COG4174	ABC transporter (Permease)
AL545_RS23490	COG0811	peptide transport
AL545_RS23495	COG0848	biopolymer transport protein
AL545_RS23515	COG0194	GDP metabolic process
AL545_RS23525	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AL545_RS23530	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AL545_RS23535	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AL545_RS23540	COG2233	PERMEase
AL545_RS23560	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AL545_RS23570	COG2183	response to ionizing radiation
AL545_RS23585	COG1040	competence protein
AL545_RS23595	COG0494	nUDIX hydrolase
AL545_RS23600	COG1218	3'(2'),5'-bisphosphate nucleotidase
AL545_RS23610	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
AL545_RS23615	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
AL545_RS23620	COG3156	type II secretion system protein K
AL545_RS23625	COG4795	General secretion pathway protein
AL545_RS23630	COG2165	general secretion pathway protein
AL545_RS23635	COG2165	general secretion pathway protein
AL545_RS23640	COG2165	general secretion pathway protein
AL545_RS23645	COG1459	type II secretion system
AL545_RS23650	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AL545_RS23660	COG3031	protein transport across the cell outer membrane
AL545_RS23665	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AL545_RS23670	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AL545_RS23675	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AL545_RS23685	COG0456	acetyltransferase
AL545_RS23690	COG1490	D-aminoacyl-tRNA deacylase activity
AL545_RS23695	COG1295	ribonuclease BN
AL545_RS23705	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AL545_RS23710	COG1217	gtp-binding protein TYPA
AL545_RS23715	COG0174	glutamine synthetase
AL545_RS23725	COG3852	Histidine kinase
AL545_RS23730	COG2204	response regulator
AL545_RS23740	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AL545_RS23775	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AL545_RS23780	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL545_RS23780	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL545_RS23790	COG0456	acetyltransferase
AL545_RS23805	COG0084	hydrolase, TatD family'
AL545_RS23820	COG0805	protein transport
AL545_RS23825	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AL545_RS23835	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AL545_RS23840	COG3165	ubiquinone biosynthetic process from chorismate
AL545_RS23845	COG2226	methyltransferase
AL545_RS23850	COG1322	Protein conserved in bacteria
AL545_RS23865	COG0628	permease
AL545_RS23895	COG1597	lipid kinase activity
AL545_RS23925	COG2081	HI0933 family
AL545_RS23935	COG1528	Iron-storage protein
AL545_RS23940	COG0589	response to stress
AL545_RS23955	COG0742	ribosomal rna small subunit methyltransferase
AL545_RS23960	COG5001	Diguanylate cyclase
AL545_RS23960	COG5002	protein histidine kinase activity
AL545_RS23965	COG1522	sequence-specific DNA binding
AL545_RS23975	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AL545_RS23980	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL545_RS24020	COG0583	DNA-binding transcription factor activity
AL545_RS24025	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AL545_RS24030	COG0800	Aldolase
AL545_RS24035	COG2610	gluconate transmembrane transporter activity
AL545_RS24040	COG3265	gluconokinase activity
AL545_RS24045	COG0129	dihydroxy-acid dehydratase activity
AL545_RS24060	COG0583	DNA-binding transcription factor activity
AL545_RS24065	COG1609	Transcriptional regulator
AL545_RS24105	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL545_RS24110	COG0601	transmembrane transport
AL545_RS24115	COG4166	transmembrane transport
AL545_RS24175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL545_RS24180	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL545_RS24185	COG2960	long-chain fatty acid transporting porin activity
AL545_RS24190	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AL545_RS24195	COG0583	DNA-binding transcription factor activity
AL545_RS24230	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AL545_RS24250	COG0009	L-threonylcarbamoyladenylate synthase
AL545_RS24255	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AL545_RS24260	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AL545_RS24265	COG0551	DNA topoisomerase type I activity
AL545_RS24275	COG2922	Belongs to the Smg family
AL545_RS24280	COG0758	DNA mediated transformation
AL545_RS24290	COG0242	peptide deformylase activity
AL545_RS24295	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AL545_RS24300	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AL545_RS24300	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AL545_RS24305	COG0569	domain protein
AL545_RS24310	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AL545_RS24320	COG1272	protein, Hemolysin III
AL545_RS24325	COG4326	sporulation control protein
AL545_RS24335	COG3084	Protein conserved in bacteria
AL545_RS24345	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AL545_RS24350	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AL545_RS24355	COG0204	Acyl-transferase
AL545_RS24365	COG0606	chelatase, subunit chli
AL545_RS24375	COG3978	acetolactate synthase activity
AL545_RS24380	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AL545_RS24385	COG0129	dihydroxy-acid dehydratase activity
AL545_RS24395	COG0583	DNA-binding transcription factor activity
AL545_RS24400	COG2814	Major facilitator Superfamily
AL545_RS24405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL545_RS24410	COG0765	amino acid transport
AL545_RS24420	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AL545_RS24425	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AL545_RS24430	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AL545_RS24435	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AL545_RS24440	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AL545_RS24445	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AL545_RS24455	COG0356	it plays a direct role in the translocation of protons across the membrane
AL545_RS24460	COG3312	ion transport
AL545_RS24465	COG1475	DNA binding
AL545_RS24470	COG1192	Involved in chromosome partitioning
AL545_RS24475	COG0357	Ribosomal RNA small subunit methyltransferase G
AL545_RS24480	COG0445	tRNA wobble uridine modification
AL545_RS24485	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AL545_RS24495	COG0706	membrane insertase activity
AL545_RS24505	COG0594	ribonuclease P activity
AL545_RS24515	COG1126	abc transporter atp-binding protein
AL545_RS24535	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AL545_RS24540	COG0592	DNA-directed DNA polymerase activity