locus-tag	class	description
HUO05_RS00055	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HUO05_RS00065	COG2974	May be involved in recombination
HUO05_RS00070	COG0745	RESPONSE REGULATOR receiver
HUO05_RS00085	COG0248	Ppx GppA phosphatase
HUO05_RS00090	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HUO05_RS00095	COG0573	inorganic phosphate transmembrane transporter activity
HUO05_RS00100	COG0581	inorganic phosphate transmembrane transporter activity
HUO05_RS00105	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HUO05_RS00110	COG0704	Plays a role in the regulation of phosphate uptake
HUO05_RS00120	COG3142	Participates in the control of copper homeostasis
HUO05_RS00125	COG0450	alkyl hydroperoxide reductase
HUO05_RS00130	COG0583	DNA-binding transcription factor activity
HUO05_RS00135	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HUO05_RS00145	COG0517	IMP dehydrogenase activity
HUO05_RS00155	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HUO05_RS00165	COG1862	Preprotein translocase
HUO05_RS00170	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HUO05_RS00175	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HUO05_RS00190	COG0483	inositol monophosphate 1-phosphatase activity
HUO05_RS00195	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HUO05_RS00205	COG1104	cysteine desulfurase activity
HUO05_RS00210	COG0822	iron-sulfur transferase activity
HUO05_RS00225	COG0443	Heat shock 70 kDa protein
HUO05_RS00230	COG0633	Ferredoxin
HUO05_RS00235	COG2975	iron-sulfur cluster assembly
HUO05_RS00245	COG0105	UTP biosynthetic process
HUO05_RS00260	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HUO05_RS00265	COG0124	histidyl-tRNA synthetase
HUO05_RS00270	COG2976	Protein conserved in bacteria
HUO05_RS00275	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HUO05_RS00280	COG1160	GTP binding
HUO05_RS00300	COG0516	GMP reductase activity
HUO05_RS00300	COG0517	IMP dehydrogenase activity
HUO05_RS00305	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HUO05_RS00305	COG0519	Catalyzes the synthesis of GMP from XMP
HUO05_RS00310	COG1757	Na H antiporter
HUO05_RS00320	COG1584	GPR1 FUN34 yaaH family protein
HUO05_RS00325	COG1115	amino acid carrier protein
HUO05_RS00340	COG2873	o-acetylhomoserine
HUO05_RS00345	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HUO05_RS00365	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HUO05_RS00365	COG3153	acetyltransferase
HUO05_RS00370	COG0583	DNA-binding transcription factor activity
HUO05_RS00415	COG0328	RNA-DNA hybrid ribonuclease activity
HUO05_RS00430	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HUO05_RS00435	COG2867	negative regulation of translational initiation
HUO05_RS00440	COG2914	Belongs to the UPF0125 (RnfH) family
HUO05_RS00445	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HUO05_RS00455	COG0497	DNA recombination
HUO05_RS00465	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HUO05_RS00470	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HUO05_RS00475	COG1301	dicarboxylic acid transport
HUO05_RS00485	COG0484	heat shock protein binding
HUO05_RS00515	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HUO05_RS00525	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HUO05_RS00530	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HUO05_RS00530	COG0047	phosphoribosylformylglycinamidine synthase activity
HUO05_RS00560	COG2195	Cleaves the N-terminal amino acid of tripeptides
HUO05_RS00565	COG2252	PERMEase
HUO05_RS00570	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HUO05_RS00585	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HUO05_RS00590	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HUO05_RS00595	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HUO05_RS00600	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HUO05_RS00600	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HUO05_RS00615	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HUO05_RS00625	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HUO05_RS00630	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HUO05_RS00635	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HUO05_RS00640	COG0142	geranyltranstransferase activity
HUO05_RS00645	COG1722	exodeoxyribonuclease VII activity
HUO05_RS00650	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HUO05_RS00660	COG0301	tRNA thio-modification
HUO05_RS00660	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HUO05_RS00665	COG0583	DNA-binding transcription factor activity
HUO05_RS00675	COG2363	Small membrane protein
HUO05_RS00685	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HUO05_RS00690	COG1611	Belongs to the LOG family
HUO05_RS00705	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HUO05_RS00705	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HUO05_RS00715	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
HUO05_RS00720	COG1464	Belongs to the NlpA lipoprotein family
HUO05_RS00725	COG2011	ABC-type metal ion transport system permease component
HUO05_RS00730	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HUO05_RS00735	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HUO05_RS00750	COG0366	Alpha amylase catalytic
HUO05_RS00765	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HUO05_RS00770	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HUO05_RS00775	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HUO05_RS00780	COG0321	lipoyl(octanoyl) transferase activity
HUO05_RS00790	COG1686	Belongs to the peptidase S11 family
HUO05_RS00795	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HUO05_RS00800	COG0772	Belongs to the SEDS family
HUO05_RS00805	COG0768	penicillin binding
HUO05_RS00810	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HUO05_RS00815	COG0799	negative regulation of ribosome biogenesis
HUO05_RS00820	COG1466	dna polymerase III delta subunit
HUO05_RS00825	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
HUO05_RS00830	COG0495	leucyl-tRNA aminoacylation
HUO05_RS00835	COG2888	peptidyl-tyrosine sulfation
HUO05_RS00840	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HUO05_RS00845	COG4535	Mg2 and Co2 transporter CorC
HUO05_RS00850	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HUO05_RS00855	COG1702	phosphate starvation-inducible protein PhoH
HUO05_RS00860	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HUO05_RS00865	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUO05_RS00970	COG0012	GTP binding
HUO05_RS00975	COG0193	aminoacyl-tRNA hydrolase activity
HUO05_RS00980	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HUO05_RS00985	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HUO05_RS00990	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HUO05_RS00995	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HUO05_RS01005	COG2890	protein-(glutamine-N5) methyltransferase activity
HUO05_RS01010	COG3094	Invasion gene expression up-regulator, SirB
HUO05_RS01015	COG2912	Transglutaminase-like superfamily
HUO05_RS01020	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HUO05_RS01025	COG0737	Belongs to the 5'-nucleotidase family
HUO05_RS01030	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HUO05_RS01035	COG1187	pseudouridine synthase activity
HUO05_RS01040	COG2840	Smr protein MutS2
HUO05_RS01080	COG2608	mercury ion transmembrane transporter activity
HUO05_RS01080	COG2217	Heavy metal translocating P-type atpase
HUO05_RS01090	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HUO05_RS01145	COG0835	chemotaxis
HUO05_RS01145	COG0784	Response regulator, receiver
HUO05_RS01150	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HUO05_RS01155	COG1815	bacterial-type flagellum-dependent cell motility
HUO05_RS01160	COG1558	bacterial-type flagellum-dependent cell motility
HUO05_RS01170	COG1749	Flagellar hook protein flgE
HUO05_RS01175	COG4787	bacterial-type flagellum-dependent cell motility
HUO05_RS01185	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HUO05_RS01190	COG1706	bacterial-type flagellum-dependent cell motility
HUO05_RS01195	COG1705	Flagellar rod assembly protein muramidase FlgJ
HUO05_RS01195	COG3951	Flagellar rod assembly protein muramidase FlgJ
HUO05_RS01205	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HUO05_RS01210	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HUO05_RS01215	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HUO05_RS01220	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HUO05_RS01225	COG2190	(PTS) system
HUO05_RS01230	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HUO05_RS01235	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HUO05_RS01240	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HUO05_RS01245	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
HUO05_RS01250	COG3115	cell septum assembly
HUO05_RS01255	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HUO05_RS01275	COG0330	HflC and HflK could
HUO05_RS01280	COG2194	sulfuric ester hydrolase activity
HUO05_RS01300	COG1192	Involved in chromosome partitioning
HUO05_RS01305	COG1215	transferase activity, transferring glycosyl groups
HUO05_RS01315	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HUO05_RS01325	COG3118	belongs to the thioredoxin family
HUO05_RS01330	COG0300	oxidoreductase activity
HUO05_RS01335	COG1090	epimerase
HUO05_RS01360	COG0622	Phosphoesterase
HUO05_RS01380	COG3710	Transcriptional regulator
HUO05_RS01385	COG0326	Molecular chaperone. Has ATPase activity
HUO05_RS01395	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HUO05_RS01400	COG3104	oligopeptide transport
HUO05_RS01405	COG0250	Participates in transcription elongation, termination and antitermination
HUO05_RS01410	COG0367	asparagine synthase
HUO05_RS01415	COG4651	solute:proton antiporter activity
HUO05_RS01415	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HUO05_RS01420	COG1940	carbohydrate kinase activity
HUO05_RS01420	COG1846	Transcriptional regulator
HUO05_RS01425	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HUO05_RS01430	COG1263	PTS System
HUO05_RS01430	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HUO05_RS01430	COG2190	(PTS) system
HUO05_RS01435	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HUO05_RS01440	COG0735	belongs to the Fur family
HUO05_RS01450	COG0716	FMN binding
HUO05_RS01460	COG0596	Alpha beta hydrolase
HUO05_RS01465	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HUO05_RS01470	COG0033	Phosphoglucomutase
HUO05_RS01480	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HUO05_RS01495	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HUO05_RS01500	COG1053	succinate dehydrogenase
HUO05_RS01505	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HUO05_RS01510	COG0567	Dehydrogenase, E1 component
HUO05_RS01515	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUO05_RS01520	COG0045	succinate-CoA ligase (ADP-forming) activity
HUO05_RS01530	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HUO05_RS01535	COG1121	(ABC) transporter
HUO05_RS01540	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HUO05_RS01545	COG4977	sequence-specific DNA binding
HUO05_RS01550	COG1918	ferrous iron import across plasma membrane
HUO05_RS01570	COG0018	arginyl-trna synthetase
HUO05_RS01575	COG3102	Protein conserved in bacteria
HUO05_RS01590	COG0788	formyltetrahydrofolate deformylase activity
HUO05_RS01595	COG1199	ATP-dependent helicase activity
HUO05_RS01600	COG1214	PFAM Peptidase M22, glycoprotease
HUO05_RS01610	COG3065	identical protein binding
HUO05_RS01615	COG2267	carboxylic ester hydrolase activity
HUO05_RS01620	COG0318	PFAM AMP-dependent synthetase and ligase
HUO05_RS01625	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HUO05_RS01630	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HUO05_RS01635	COG2894	cell division
HUO05_RS01640	COG0850	regulation of cytokinetic process
HUO05_RS01645	COG3100	YcgL domain-containing protein
HUO05_RS01650	COG2951	lytic endotransglycosylase activity
HUO05_RS01660	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HUO05_RS01665	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HUO05_RS01680	COG1028	Short-chain dehydrogenase reductase Sdr
HUO05_RS01690	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HUO05_RS01720	COG1216	Glycosyl transferase, family 2
HUO05_RS01725	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HUO05_RS01740	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUO05_RS01745	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUO05_RS01780	COG0513	Belongs to the DEAD box helicase family
HUO05_RS01785	COG0569	domain protein
HUO05_RS01790	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HUO05_RS01805	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HUO05_RS01810	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HUO05_RS01815	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HUO05_RS01820	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HUO05_RS01835	COG0544	peptidyl-prolyl cis-trans isomerase activity
HUO05_RS01845	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HUO05_RS01850	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HUO05_RS01855	COG0776	regulation of translation
HUO05_RS01860	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HUO05_RS01865	COG1555	photosystem II stabilization
HUO05_RS01880	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HUO05_RS01885	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HUO05_RS01890	COG0436	Aminotransferase
HUO05_RS01895	COG1169	isochorismate synthase
HUO05_RS01900	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HUO05_RS01910	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HUO05_RS01930	COG2855	membrane
HUO05_RS01935	COG0477	Major facilitator Superfamily
HUO05_RS01980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HUO05_RS01985	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HUO05_RS02000	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HUO05_RS02005	COG1522	sequence-specific DNA binding
HUO05_RS02015	COG1946	Acyl-CoA thioesterase
HUO05_RS02020	COG3126	Type III secretion system lipoprotein chaperone (YscW)
HUO05_RS02035	COG3706	GGDEF domain
HUO05_RS02045	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HUO05_RS02050	COG0517	IMP dehydrogenase activity
HUO05_RS02050	COG0516	GMP reductase activity
HUO05_RS02075	COG0537	adenosine 5'-monophosphoramidase activity
HUO05_RS02100	COG3150	esterase
HUO05_RS02105	COG1252	NADH dehydrogenase
HUO05_RS02120	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HUO05_RS02130	COG4591	ABC-type transport system involved in lipoprotein release permease component
HUO05_RS02135	COG1136	(ABC) transporter
HUO05_RS02140	COG4591	ABC-type transport system involved in lipoprotein release permease component
HUO05_RS02150	COG2333	competence protein COMEC
HUO05_RS02150	COG0658	competence protein
HUO05_RS02155	COG1132	(ABC) transporter
HUO05_RS02175	COG2719	SpoVR family
HUO05_RS02180	COG2718	Belongs to the UPF0229 family
HUO05_RS02185	COG2766	serine protein kinase
HUO05_RS02190	COG3013	Belongs to the UPF0304 family
HUO05_RS02200	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HUO05_RS02210	COG1882	Formate acetyltransferase
HUO05_RS02250	COG0708	Exodeoxyribonuclease III
HUO05_RS02260	COG3923	Primosomal replication protein n
HUO05_RS02265	COG0730	response to heat
HUO05_RS02270	COG1199	ATP-dependent helicase activity
HUO05_RS02275	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HUO05_RS02280	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HUO05_RS02285	COG1187	pseudouridine synthase activity
HUO05_RS02295	COG1278	Cold shock
HUO05_RS02300	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HUO05_RS02305	COG0542	response to heat
HUO05_RS02310	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HUO05_RS02315	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HUO05_RS02320	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HUO05_RS02345	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HUO05_RS02350	COG0297	glycogen (starch) synthase activity
HUO05_RS02370	COG3070	regulator of competence-specific genes
HUO05_RS02375	COG1609	Transcriptional regulator
HUO05_RS02380	COG3381	protein complex oligomerization
HUO05_RS02385	COG0745	RESPONSE REGULATOR receiver
HUO05_RS02390	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HUO05_RS02395	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HUO05_RS02405	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HUO05_RS02410	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HUO05_RS02430	COG4067	protein conserved in archaea
HUO05_RS02430	COG0189	ligase activity
HUO05_RS02435	COG0500	methyltransferase
HUO05_RS02445	COG1801	Protein of unknown function DUF72
HUO05_RS02455	COG0217	transcriptional regulatory protein
HUO05_RS02460	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HUO05_RS02465	COG0632	four-way junction helicase activity
HUO05_RS02470	COG2255	four-way junction helicase activity
HUO05_RS02475	COG1271	oxidase subunit
HUO05_RS02480	COG1294	oxidase, subunit
HUO05_RS02485	COG4890	Cyd operon protein YbgT
HUO05_RS02495	COG0824	Thioesterase
HUO05_RS02500	COG0811	peptide transport
HUO05_RS02515	COG0823	Involved in the tonB-independent uptake of proteins
HUO05_RS02520	COG2885	chlorophyll binding
HUO05_RS02525	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HUO05_RS02530	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HUO05_RS02540	COG3766	membrane
HUO05_RS02550	COG0754	glutathionylspermidine amidase activity
HUO05_RS02560	COG5002	protein histidine kinase activity
HUO05_RS02560	COG0784	Response regulator, receiver
HUO05_RS02590	COG1192	Involved in chromosome partitioning
HUO05_RS02595	COG1294	oxidase, subunit
HUO05_RS02600	COG1271	oxidase subunit
HUO05_RS02620	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HUO05_RS02625	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HUO05_RS02650	COG3568	Endonuclease Exonuclease Phosphatase
HUO05_RS02675	COG0583	DNA-binding transcription factor activity
HUO05_RS02685	COG0686	Belongs to the AlaDH PNT family
HUO05_RS02695	COG1674	ftsk spoiiie
HUO05_RS02705	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HUO05_RS02735	COG2226	methyltransferase
HUO05_RS02735	COG1073	alpha beta
HUO05_RS02740	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HUO05_RS02760	COG0300	oxidoreductase activity
HUO05_RS02775	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HUO05_RS02785	COG2268	Band 7 protein
HUO05_RS02795	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HUO05_RS02800	COG2915	High frequency lysogenization protein hflD homolog
HUO05_RS02815	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUO05_RS02825	COG1757	Na H antiporter
HUO05_RS02835	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HUO05_RS02845	COG0131	Imidazoleglycerol-phosphate dehydratase
HUO05_RS02845	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HUO05_RS02850	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HUO05_RS02855	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HUO05_RS02865	COG0140	phosphoribosyl-ATP diphosphatase activity
HUO05_RS02865	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HUO05_RS02870	COG3012	SEC-C Motif Domain Protein
HUO05_RS02875	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HUO05_RS02880	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HUO05_RS02885	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HUO05_RS02890	COG0215	cysteine-tRNA ligase activity
HUO05_RS02895	COG1435	thymidine kinase activity
HUO05_RS02900	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HUO05_RS02925	COG2116	formate transmembrane transporter activity
HUO05_RS02930	COG0390	transport system, permease component
HUO05_RS02935	COG4459	periplasmic nitrate reductase
HUO05_RS02940	COG3005	denitrification pathway
HUO05_RS02945	COG0243	molybdopterin cofactor binding
HUO05_RS02960	COG1227	inorganic diphosphatase activity
HUO05_RS02970	COG4172	Belongs to the ABC transporter superfamily
HUO05_RS02980	COG4171	peptide transport system, permease
HUO05_RS02995	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HUO05_RS03000	COG1842	Phage shock protein A
HUO05_RS03010	COG1983	PspC domain protein
HUO05_RS03030	COG2818	Glycosylase
HUO05_RS03035	COG5380	lipid catabolic process
HUO05_RS03040	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HUO05_RS03045	COG0626	cystathionine gamma-synthase activity
HUO05_RS03055	COG0733	neurotransmitter:sodium symporter activity
HUO05_RS03060	COG0564	pseudouridine synthase activity
HUO05_RS03070	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HUO05_RS03075	COG1151	hydroxylamine reductase activity
HUO05_RS03080	COG3604	Transcriptional regulator
HUO05_RS03090	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HUO05_RS03095	COG4136	ATPase activity
HUO05_RS03100	COG4135	transport system, permease component
HUO05_RS03105	COG4134	Bacterial extracellular solute-binding protein
HUO05_RS03115	COG3313	Fe-S protein
HUO05_RS03135	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HUO05_RS03140	COG2205	protein histidine kinase activity
HUO05_RS03145	COG0745	RESPONSE REGULATOR receiver
HUO05_RS03155	COG1061	Type III restriction enzyme res subunit
HUO05_RS03160	COG1187	pseudouridine synthase activity
HUO05_RS03165	COG2814	Major facilitator Superfamily
HUO05_RS03175	COG0702	epimerase
HUO05_RS03200	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HUO05_RS03210	COG1960	acyl-CoA dehydrogenase activity
HUO05_RS03215	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HUO05_RS03220	COG2985	domain, Protein
HUO05_RS03220	COG3273	potassium ion transport
HUO05_RS03225	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HUO05_RS03235	COG1737	Transcriptional regulator
HUO05_RS03240	COG0076	glutamate decarboxylase activity
HUO05_RS03250	COG2431	L-lysine efflux transmembrane transporter activity
HUO05_RS03260	COG3070	regulator of competence-specific genes
HUO05_RS03275	COG4191	Histidine kinase
HUO05_RS03275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUO05_RS03285	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HUO05_RS03290	COG3048	D-serine ammonia-lyase activity
HUO05_RS03295	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HUO05_RS03300	COG4988	ABC transporter
HUO05_RS03305	COG0492	ferredoxin-NADP+ reductase activity
HUO05_RS03330	COG0471	metal ion transport
HUO05_RS03335	COG2949	membrane
HUO05_RS03340	COG0281	malic enzyme
HUO05_RS03345	COG1643	Atp-dependent helicase
HUO05_RS03360	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HUO05_RS03395	COG0277	FAD linked oxidase domain protein
HUO05_RS03395	COG0247	lactate metabolic process
HUO05_RS03410	COG2986	histidine ammonia-lyase
HUO05_RS03415	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HUO05_RS03420	COG0010	Belongs to the arginase family
HUO05_RS03425	COG1228	amidohydrolase
HUO05_RS03430	COG2188	Transcriptional regulator
HUO05_RS03445	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HUO05_RS03455	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HUO05_RS03465	COG0393	Putative heavy-metal-binding
HUO05_RS03495	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HUO05_RS03500	COG0072	phenylalanine-tRNA ligase activity
HUO05_RS03500	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUO05_RS03510	COG0776	regulation of translation
HUO05_RS03520	COG0500	methyltransferase
HUO05_RS03525	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HUO05_RS03530	COG0295	cytidine deaminase activity
HUO05_RS03535	COG1346	cytolysis
HUO05_RS03540	COG1380	Effector of murein hydrolase LrgA
HUO05_RS03545	COG2925	Exonuclease
HUO05_RS03620	COG1484	DNA-dependent DNA replication
HUO05_RS03775	COG0702	epimerase
HUO05_RS03780	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HUO05_RS03785	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HUO05_RS03805	COG2988	succinylglutamate desuccinylase activity
HUO05_RS03810	COG4139	cobalamin transport
HUO05_RS03815	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
HUO05_RS03835	COG0583	DNA-binding transcription factor activity
HUO05_RS03845	COG1451	nucleotide metabolic process
HUO05_RS03850	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
HUO05_RS03880	COG3938	Belongs to the proline racemase family
HUO05_RS03895	COG2423	ornithine cyclodeaminase activity
HUO05_RS03900	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUO05_RS03905	COG3842	ATPase activity
HUO05_RS03910	COG1176	ABC-type spermidine putrescine transport system, permease component I
HUO05_RS03915	COG1177	transmembrane transport
HUO05_RS03925	COG3291	Pkd domain containing protein
HUO05_RS03945	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUO05_RS03950	COG0601	transmembrane transport
HUO05_RS03960	COG2195	Cleaves the N-terminal amino acid of tripeptides
HUO05_RS03970	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HUO05_RS03980	COG0625	glutathione transferase activity
HUO05_RS04030	COG3755	Protein conserved in bacteria
HUO05_RS04050	COG1742	UPF0060 membrane protein
HUO05_RS04065	COG1757	Na H antiporter
HUO05_RS04070	COG0174	glutamine synthetase
HUO05_RS04075	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HUO05_RS04080	COG1396	sequence-specific DNA binding
HUO05_RS04080	COG1917	Cupin 2, conserved barrel domain protein
HUO05_RS04085	COG1012	belongs to the aldehyde dehydrogenase family
HUO05_RS04090	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HUO05_RS04100	COG2957	Belongs to the agmatine deiminase family
HUO05_RS04105	COG1012	belongs to the aldehyde dehydrogenase family
HUO05_RS04110	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HUO05_RS04115	COG2200	EAL domain
HUO05_RS04125	COG1846	Transcriptional regulator
HUO05_RS04130	COG2315	Protein conserved in bacteria
HUO05_RS04170	COG3063	Type IV pilus biogenesis stability protein PilW
HUO05_RS04175	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HUO05_RS04190	COG1560	Kdo2-lipid A biosynthetic process
HUO05_RS04195	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HUO05_RS04210	COG1115	amino acid carrier protein
HUO05_RS04235	COG1368	sulfuric ester hydrolase activity
HUO05_RS04240	COG2113	Glycine betaine
HUO05_RS04245	COG4176	ABC-type proline glycine betaine transport system permease component
HUO05_RS04265	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HUO05_RS04270	COG0456	acetyltransferase
HUO05_RS04275	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HUO05_RS04280	COG0662	Cupin 2, conserved barrel domain protein
HUO05_RS04285	COG0527	aspartate kinase activity
HUO05_RS04290	COG3119	arylsulfatase activity
HUO05_RS04305	COG0641	radical SAM
HUO05_RS04320	COG3119	arylsulfatase activity
HUO05_RS04345	COG1538	Outer membrane efflux protein
HUO05_RS04360	COG1349	DNA-binding transcription factor activity
HUO05_RS04365	COG0673	inositol 2-dehydrogenase activity
HUO05_RS04370	COG4702	Belongs to the UPF0303 family
HUO05_RS04395	COG0471	metal ion transport
HUO05_RS04410	COG5001	Diguanylate cyclase
HUO05_RS04410	COG3300	MHYT domain
HUO05_RS04425	COG1328	CTP reductase activity
HUO05_RS04430	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HUO05_RS04440	COG0861	Integral membrane protein TerC family
HUO05_RS04450	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HUO05_RS04460	COG0814	amino acid
HUO05_RS04475	COG1120	ATPase activity
HUO05_RS04480	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HUO05_RS04500	COG1132	(ABC) transporter
HUO05_RS04505	COG1132	(ABC) transporter
HUO05_RS04520	COG0583	DNA-binding transcription factor activity
HUO05_RS04545	COG0443	Heat shock 70 kDa protein
HUO05_RS04550	COG0443	Heat shock 70 kDa protein
HUO05_RS04595	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HUO05_RS04600	COG1643	Atp-dependent helicase
HUO05_RS04615	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HUO05_RS04625	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HUO05_RS04630	COG1215	transferase activity, transferring glycosyl groups
HUO05_RS04635	COG0438	transferase activity, transferring glycosyl groups
HUO05_RS04665	COG0438	transferase activity, transferring glycosyl groups
HUO05_RS04670	COG0297	glycogen (starch) synthase activity
HUO05_RS04675	COG2204	response regulator
HUO05_RS04705	COG1793	dna ligase
HUO05_RS04715	COG0534	Mate efflux family protein
HUO05_RS04720	COG0307	riboflavin synthase, alpha
HUO05_RS04730	COG3001	Fructosamine kinase
HUO05_RS04740	COG3706	GGDEF domain
HUO05_RS04750	COG0791	NLP P60 protein
HUO05_RS04785	COG1940	carbohydrate kinase activity
HUO05_RS04795	COG0303	'Molybdopterin
HUO05_RS04800	COG0746	molybdenum cofactor guanylyltransferase activity
HUO05_RS04805	COG3842	ATPase activity
HUO05_RS04820	COG2204	response regulator
HUO05_RS04825	COG4191	Histidine kinase
HUO05_RS04830	COG0488	(ABC) transporter
HUO05_RS04835	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HUO05_RS04855	COG3381	protein complex oligomerization
HUO05_RS04865	COG0243	molybdopterin cofactor binding
HUO05_RS04865	COG3383	formate dehydrogenase (NAD+) activity
HUO05_RS04870	COG0437	4 iron, 4 sulfur cluster binding
HUO05_RS04895	COG0004	ammonium transporteR
HUO05_RS04905	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HUO05_RS04910	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HUO05_RS04920	COG1177	transmembrane transport
HUO05_RS04930	COG3842	ATPase activity
HUO05_RS04955	COG0589	response to stress
HUO05_RS04960	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUO05_RS04975	COG2217	Heavy metal translocating P-type atpase
HUO05_RS04985	COG2010	Cytochrome c
HUO05_RS05000	COG3278	Belongs to the heme-copper respiratory oxidase family
HUO05_RS05015	COG0784	Response regulator, receiver
HUO05_RS05015	COG2205	protein histidine kinase activity
HUO05_RS05145	COG3120	sequence-specific DNA binding
HUO05_RS05150	COG1067	ATP-dependent peptidase activity
HUO05_RS05155	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HUO05_RS05180	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HUO05_RS05180	COG0116	Belongs to the methyltransferase superfamily
HUO05_RS05190	COG0167	dihydroorotate dehydrogenase activity
HUO05_RS05195	COG2902	Dehydrogenase
HUO05_RS05205	COG0308	aminopeptidase N
HUO05_RS05220	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
HUO05_RS05225	COG1956	GAF domain-containing protein
HUO05_RS05230	COG1132	(ABC) transporter
HUO05_RS05235	COG2995	paraquat-inducible protein a
HUO05_RS05240	COG3008	intermembrane lipid transfer
HUO05_RS05265	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HUO05_RS05270	COG1666	GTP binding
HUO05_RS05280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUO05_RS05285	COG4597	amino acid ABC transporter
HUO05_RS05290	COG0765	amino acid transport
HUO05_RS05295	COG1126	abc transporter atp-binding protein
HUO05_RS05300	COG0670	Belongs to the BI1 family
HUO05_RS05310	COG2920	part of a sulfur-relay system
HUO05_RS05315	COG1254	Belongs to the acylphosphatase family
HUO05_RS05340	COG2885	chlorophyll binding
HUO05_RS05365	COG2203	Gaf domain
HUO05_RS05365	COG2199	diguanylate cyclase activity
HUO05_RS05370	COG1414	Transcriptional regulator
HUO05_RS05380	COG0656	L-ascorbic acid biosynthetic process
HUO05_RS05385	COG0583	DNA-binding transcription factor activity
HUO05_RS05395	COG0583	DNA-binding transcription factor activity
HUO05_RS05400	COG2814	Major facilitator Superfamily
HUO05_RS05420	COG1335	isochorismatase
HUO05_RS05425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUO05_RS05440	COG1410	methionine synthase
HUO05_RS05440	COG0646	methionine synthase
HUO05_RS05445	COG1126	abc transporter atp-binding protein
HUO05_RS05450	COG0765	amino acid transport
HUO05_RS05455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUO05_RS05470	COG0583	DNA-binding transcription factor activity
HUO05_RS05485	COG0583	DNA-binding transcription factor activity
HUO05_RS05490	COG0583	DNA-binding transcription factor activity
HUO05_RS05505	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HUO05_RS05510	COG0602	queuosine metabolic process
HUO05_RS05515	COG0561	phosphatase activity
HUO05_RS05540	COG2828	Protein conserved in bacteria
HUO05_RS05550	COG0372	Belongs to the citrate synthase family
HUO05_RS05555	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HUO05_RS05590	COG0730	response to heat
HUO05_RS05595	COG2358	TRAP transporter, solute receptor (TAXI family
HUO05_RS05610	COG0457	Tetratricopeptide repeat
HUO05_RS05680	COG4790	Type iii secretion
HUO05_RS05685	COG4794	Type iii secretion
HUO05_RS05690	COG4791	protein targeting
HUO05_RS05695	COG4792	protein secretion
HUO05_RS05700	COG2207	Transcriptional regulator
HUO05_RS05730	COG3177	Filamentation induced by cAMP protein fic
HUO05_RS05750	COG4669	(LipO)protein
HUO05_RS05820	COG1012	belongs to the aldehyde dehydrogenase family
HUO05_RS05825	COG3284	Transcriptional regulator
HUO05_RS05840	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HUO05_RS05845	COG0363	glucosamine-6-phosphate deaminase activity
HUO05_RS05850	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HUO05_RS05855	COG2207	Transcriptional regulator
HUO05_RS05865	COG4565	transcriptional regulatory protein
HUO05_RS05870	COG3290	protein histidine kinase activity
HUO05_RS05885	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HUO05_RS05915	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HUO05_RS05930	COG1074	ATP-dependent DNA helicase activity
HUO05_RS05940	COG0583	DNA-binding transcription factor activity
HUO05_RS05945	COG4771	TonB-dependent receptor
HUO05_RS05960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HUO05_RS06030	COG4974	Belongs to the 'phage' integrase family
HUO05_RS06040	COG2985	domain, Protein
HUO05_RS06065	COG2272	Belongs to the type-B carboxylesterase lipase family
HUO05_RS06070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HUO05_RS06075	COG0729	surface antigen
HUO05_RS06085	COG1280	lysine exporter protein (LysE YggA)
HUO05_RS06090	COG1280	lysine exporter protein (LysE YggA)
HUO05_RS06095	COG5507	3-demethylubiquinone-9 3-methyltransferase
HUO05_RS06115	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HUO05_RS06120	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HUO05_RS06125	COG0110	maltose O-acetyltransferase activity
HUO05_RS06180	COG2026	Addiction module toxin, RelE StbE family
HUO05_RS06195	COG2211	Major facilitator Superfamily
HUO05_RS06220	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HUO05_RS06225	COG1028	Short-chain dehydrogenase reductase Sdr
HUO05_RS06230	COG1169	isochorismate synthase
HUO05_RS06235	COG1021	2,3-dihydroxybenzoate-AMP ligase
HUO05_RS06240	COG3433	isochorismatase activity
HUO05_RS06240	COG1535	isochorismatase
HUO05_RS06245	COG4592	Periplasmic binding protein
HUO05_RS06255	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUO05_RS06260	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUO05_RS06265	COG1120	ATPase activity
HUO05_RS06280	COG2382	esterase
HUO05_RS06285	COG4774	siderophore transport
HUO05_RS06285	COG1629	transport
HUO05_RS06305	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUO05_RS06370	COG2026	Addiction module toxin, RelE StbE family
HUO05_RS06540	COG0346	lactoylglutathione lyase activity
HUO05_RS06690	COG1683	Conserved Protein
HUO05_RS06745	COG1204	response to ionizing radiation
HUO05_RS06775	COG0582	viral genome integration into host DNA
HUO05_RS06960	COG2026	Addiction module toxin, RelE StbE family
HUO05_RS06965	COG1403	HNH endonuclease
HUO05_RS07000	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HUO05_RS07010	COG3768	UPF0283 membrane protein
HUO05_RS07015	COG3106	COG3106 Predicted ATPase
HUO05_RS07030	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HUO05_RS07035	COG0784	Response regulator, receiver
HUO05_RS07035	COG2205	protein histidine kinase activity
HUO05_RS07045	COG0494	nUDIX hydrolase
HUO05_RS07050	COG0814	amino acid
HUO05_RS07055	COG1760	l-serine dehydratase
HUO05_RS07070	COG0720	synthase
HUO05_RS07075	COG0840	transmembrane signaling receptor activity
HUO05_RS07080	COG0017	Asparaginyl-tRNA synthetase
HUO05_RS07090	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUO05_RS07105	COG1448	Aminotransferase
HUO05_RS07125	COG0840	transmembrane signaling receptor activity
HUO05_RS07130	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HUO05_RS07160	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HUO05_RS07175	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUO05_RS07180	COG3108	Peptidase M15
HUO05_RS07185	COG2989	Protein conserved in bacteria
HUO05_RS07210	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HUO05_RS07220	COG3088	subunit of a heme lyase
HUO05_RS07220	COG4235	cytochrome complex assembly
HUO05_RS07225	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUO05_RS07230	COG1138	Cytochrome C-type biogenesis protein
HUO05_RS07235	COG3301	Polysulphide reductase, NrfD
HUO05_RS07240	COG0437	4 iron, 4 sulfur cluster binding
HUO05_RS07250	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HUO05_RS07270	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HUO05_RS07275	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HUO05_RS07305	COG0019	diaminopimelate decarboxylase activity
HUO05_RS07345	COG0322	excinuclease ABC activity
HUO05_RS07350	COG2197	response regulator
HUO05_RS07355	COG0417	DNA replication proofreading
HUO05_RS07375	COG1187	pseudouridine synthase activity
HUO05_RS07385	COG0009	L-threonylcarbamoyladenylate synthase
HUO05_RS07390	COG0613	PHP domain protein
HUO05_RS07400	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HUO05_RS07405	COG0512	Glutamine amidotransferase of anthranilate synthase
HUO05_RS07415	COG0135	phosphoribosylanthranilate isomerase activity
HUO05_RS07415	COG0134	indole-3-glycerol-phosphate synthase activity
HUO05_RS07425	COG0159	tryptophan synthase activity
HUO05_RS07430	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUO05_RS07435	COG0318	PFAM AMP-dependent synthetase and ligase
HUO05_RS07440	COG1301	dicarboxylic acid transport
HUO05_RS07460	COG2917	probably involved in intracellular septation
HUO05_RS07470	COG2350	Protein conserved in bacteria
HUO05_RS07480	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HUO05_RS07485	COG0583	DNA-binding transcription factor activity
HUO05_RS07500	COG5001	Diguanylate cyclase
HUO05_RS07505	COG1032	radical SAM domain protein
HUO05_RS07525	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HUO05_RS07530	COG0463	Glycosyl transferase, family 2
HUO05_RS07535	COG0745	RESPONSE REGULATOR receiver
HUO05_RS07540	COG5002	protein histidine kinase activity
HUO05_RS07540	COG3850	Histidine kinase
HUO05_RS07590	COG1136	(ABC) transporter
HUO05_RS07590	COG0577	efflux transmembrane transporter activity
HUO05_RS07600	COG0577	efflux transmembrane transporter activity
HUO05_RS07600	COG1136	(ABC) transporter
HUO05_RS07635	COG3118	belongs to the thioredoxin family
HUO05_RS07640	COG4232	protein-disulfide reductase activity
HUO05_RS07675	COG2863	cytochrome
HUO05_RS07680	COG3258	Cytochrome c
HUO05_RS07685	COG2995	paraquat-inducible protein a
HUO05_RS07690	COG3008	intermembrane lipid transfer
HUO05_RS07690	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HUO05_RS07710	COG4166	transmembrane transport
HUO05_RS07720	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HUO05_RS07725	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HUO05_RS07735	COG0539	negative regulation of cytoplasmic translation
HUO05_RS07740	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HUO05_RS07745	COG0616	signal peptide processing
HUO05_RS07750	COG1028	Short-chain dehydrogenase reductase Sdr
HUO05_RS07765	COG0587	DNA-directed DNA polymerase activity
HUO05_RS07770	COG0784	Response regulator, receiver
HUO05_RS07770	COG0835	chemotaxis
HUO05_RS07775	COG1940	carbohydrate kinase activity
HUO05_RS07780	COG0469	pyruvate kinase activity
HUO05_RS07785	COG4667	esterase of the alpha-beta hydrolase superfamily
HUO05_RS07800	COG0733	neurotransmitter:sodium symporter activity
HUO05_RS07815	COG1263	PTS System
HUO05_RS07815	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HUO05_RS07820	COG0084	hydrolase, TatD family'
HUO05_RS07825	COG0470	DNA polymerase III
HUO05_RS07830	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HUO05_RS07835	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HUO05_RS07865	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HUO05_RS07870	COG0416	fatty acid biosynthetic process
HUO05_RS07880	COG1399	metal-binding, possibly nucleic acid-binding protein
HUO05_RS07885	COG0424	maF-like protein
HUO05_RS07890	COG0564	pseudouridine synthase activity
HUO05_RS07895	COG1530	ribonuclease E activity
HUO05_RS07900	COG0659	secondary active sulfate transmembrane transporter activity
HUO05_RS07905	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HUO05_RS07910	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HUO05_RS07920	COG0572	uridine kinase
HUO05_RS07930	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUO05_RS07930	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUO05_RS07950	COG2186	Transcriptional regulator
HUO05_RS07955	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HUO05_RS07960	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HUO05_RS07965	COG0653	protein targeting
HUO05_RS07970	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HUO05_RS07975	COG3706	GGDEF domain
HUO05_RS07980	COG0366	Alpha amylase catalytic
HUO05_RS07985	COG1122	ATPase activity
HUO05_RS07990	COG4120	Belongs to the binding-protein-dependent transport system permease family
HUO05_RS08000	COG3092	negative regulation of chromosome organization
HUO05_RS08005	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HUO05_RS08010	COG0280	phosphate acetyltransferase
HUO05_RS08010	COG0857	belongs to the CobB CobQ family
HUO05_RS08020	COG0435	Glutathione S-transferase
HUO05_RS08030	COG0444	Belongs to the ABC transporter superfamily
HUO05_RS08035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUO05_RS08040	COG0601	transmembrane transport
HUO05_RS08050	COG0314	molybdopterin synthase activity
HUO05_RS08055	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HUO05_RS08060	COG0315	cyclic pyranopterin monophosphate synthase activity
HUO05_RS08065	COG0521	Mo-molybdopterin cofactor biosynthetic process
HUO05_RS08070	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HUO05_RS08075	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HUO05_RS08080	COG2198	Histidine kinase
HUO05_RS08085	COG2204	response regulator
HUO05_RS08090	COG0556	nucleotide-excision repair
HUO05_RS08100	COG1882	Formate acetyltransferase
HUO05_RS08105	COG4657	Part of a membrane complex involved in electron transport
HUO05_RS08110	COG2878	Part of a membrane complex involved in electron transport
HUO05_RS08120	COG4658	electron transport chain
HUO05_RS08125	COG4659	FMN binding
HUO05_RS08130	COG4660	Part of a membrane complex involved in electron transport
HUO05_RS08135	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HUO05_RS08140	COG0346	lactoylglutathione lyase activity
HUO05_RS08150	COG2885	chlorophyll binding
HUO05_RS08155	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HUO05_RS08160	COG2056	Na+-H+ antiporter family
HUO05_RS08180	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HUO05_RS08200	COG1454	alcohol dehydrogenase
HUO05_RS08200	COG1012	belongs to the aldehyde dehydrogenase family
HUO05_RS08205	COG2095	MarC family integral membrane protein
HUO05_RS08210	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUO05_RS08215	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HUO05_RS08220	COG1757	Na H antiporter
HUO05_RS08235	COG3081	Nucleoid-associated protein
HUO05_RS08240	COG3082	Protein of unknown function (DUF1414)
HUO05_RS08255	COG0123	including yeast histone deacetylase and acetoin utilization protein
HUO05_RS08270	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HUO05_RS08275	COG0778	Nitroreductase
HUO05_RS08285	COG1902	pentaerythritol trinitrate reductase activity
HUO05_RS08285	COG0446	pyridine nucleotide-disulphide oxidoreductase
HUO05_RS08290	COG0616	signal peptide processing
HUO05_RS08295	COG0252	asparaginase activity
HUO05_RS08300	COG3139	Protein of unknown function (DUF1315)
HUO05_RS08310	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUO05_RS08315	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HUO05_RS08330	COG2226	methyltransferase
HUO05_RS08345	COG1785	Belongs to the alkaline phosphatase family
HUO05_RS08355	COG0346	lactoylglutathione lyase activity
HUO05_RS08360	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HUO05_RS08365	COG0668	transmembrane transport
HUO05_RS08370	COG2983	Belongs to the UPF0260 family
HUO05_RS08375	COG2261	transglycosylase associated protein
HUO05_RS08385	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HUO05_RS08390	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HUO05_RS08405	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HUO05_RS08410	COG2832	Protein of unknown function (DUF454)
HUO05_RS08415	COG0745	RESPONSE REGULATOR receiver
HUO05_RS08420	COG0583	DNA-binding transcription factor activity
HUO05_RS08425	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HUO05_RS08430	COG1286	toxin biosynthetic process
HUO05_RS08435	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HUO05_RS08440	COG0285	dihydrofolate synthase activity
HUO05_RS08445	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HUO05_RS08450	COG0101	tRNA pseudouridine synthase activity
HUO05_RS08460	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HUO05_RS08465	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HUO05_RS08470	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HUO05_RS08475	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HUO05_RS08475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HUO05_RS08480	COG0431	NADPH-dependent FMN reductase
HUO05_RS08490	COG3101	peptidyl-lysine hydroxylation
HUO05_RS08495	COG2860	membrane
HUO05_RS08500	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HUO05_RS08505	COG2890	protein-(glutamine-N5) methyltransferase activity
HUO05_RS08510	COG2840	Smr protein MutS2
HUO05_RS08515	COG2062	phosphohistidine phosphatase, SixA
HUO05_RS08530	COG1024	Enoyl-CoA hydratase
HUO05_RS08530	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUO05_RS08535	COG0183	Belongs to the thiolase family
HUO05_RS08555	COG2067	long-chain fatty acid transport protein
HUO05_RS08565	COG4235	cytochrome complex assembly
HUO05_RS08565	COG3088	subunit of a heme lyase
HUO05_RS08575	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUO05_RS08580	COG1138	Cytochrome C-type biogenesis protein
HUO05_RS08585	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HUO05_RS08590	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HUO05_RS08595	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HUO05_RS08600	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HUO05_RS08605	COG4133	protoheme IX ABC transporter activity
HUO05_RS08615	COG0835	chemotaxis
HUO05_RS08625	COG1192	Involved in chromosome partitioning
HUO05_RS08630	COG2201	protein-glutamate methylesterase activity
HUO05_RS08635	COG0643	Histidine kinase
HUO05_RS08635	COG2198	Histidine kinase
HUO05_RS08635	COG0784	Response regulator, receiver
HUO05_RS08640	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HUO05_RS08680	COG1987	bacterial-type flagellum assembly
HUO05_RS08735	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HUO05_RS08745	COG1677	Flagellar hook-basal body complex protein FliE
HUO05_RS08755	COG4191	Histidine kinase
HUO05_RS08765	COG1516	flagellar protein fliS
HUO05_RS08775	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HUO05_RS08780	COG1334	flagellar protein FlaG
HUO05_RS08785	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HUO05_RS08790	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HUO05_RS08795	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HUO05_RS08800	COG2837	iron assimilation
HUO05_RS08825	COG1393	Belongs to the ArsC family
HUO05_RS08830	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUO05_RS08850	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUO05_RS08860	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HUO05_RS08875	COG4783	chaperone-mediated protein folding
HUO05_RS08880	COG1393	Belongs to the ArsC family
HUO05_RS08900	COG2233	PERMEase
HUO05_RS08905	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HUO05_RS08910	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HUO05_RS08915	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HUO05_RS08920	COG0121	glutamine amidotransferase
HUO05_RS08925	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HUO05_RS08930	COG1960	acyl-CoA dehydrogenase activity
HUO05_RS08965	COG0328	RNA-DNA hybrid ribonuclease activity
HUO05_RS08970	COG2226	methyltransferase
HUO05_RS08975	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUO05_RS08980	COG0741	lytic transglycosylase activity
HUO05_RS08980	COG1388	LysM domain
HUO05_RS08990	COG3021	interspecies interaction between organisms
HUO05_RS08995	COG0347	Belongs to the P(II) protein family
HUO05_RS09010	COG0825	malonyl-CoA metabolic process
HUO05_RS09015	COG0587	DNA-directed DNA polymerase activity
HUO05_RS09025	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HUO05_RS09030	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HUO05_RS09040	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HUO05_RS09045	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HUO05_RS09055	COG0750	zinc metalloprotease
HUO05_RS09060	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HUO05_RS09065	COG0575	Belongs to the CDS family
HUO05_RS09070	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HUO05_RS09075	COG0233	cytoplasmic translational termination
HUO05_RS09080	COG0528	UMP kinase activity
HUO05_RS09085	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HUO05_RS09090	COG0052	Belongs to the universal ribosomal protein uS2 family
HUO05_RS09095	COG0024	Methionine aminopeptidase
HUO05_RS09100	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HUO05_RS09110	COG0564	pseudouridine synthase activity
HUO05_RS09145	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HUO05_RS09150	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUO05_RS09175	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HUO05_RS09185	COG0254	rRNA binding
HUO05_RS09190	COG1720	tRNA m6t6A37 methyltransferase activity
HUO05_RS09195	COG0442	prolyl-tRNA aminoacylation
HUO05_RS09215	COG0733	neurotransmitter:sodium symporter activity
HUO05_RS09235	COG0514	ATP-dependent DNA helicase (RecQ)
HUO05_RS09240	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HUO05_RS09260	COG1477	protein flavinylation
HUO05_RS09265	COG2871	sodium ion transport
HUO05_RS09270	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HUO05_RS09275	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HUO05_RS09280	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HUO05_RS09285	COG1805	sodium ion transport
HUO05_RS09290	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HUO05_RS09295	COG0271	Belongs to the BolA IbaG family
HUO05_RS09300	COG2813	Specifically methylates the guanine in position
HUO05_RS09305	COG3056	Lipoprotein
HUO05_RS09325	COG1595	DNA-templated transcription, initiation
HUO05_RS09340	COG3248	Nucleoside-binding outer membrane protein
HUO05_RS09345	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HUO05_RS09350	COG0693	protein deglycase activity
HUO05_RS09355	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HUO05_RS09360	COG3706	GGDEF domain
HUO05_RS09365	COG2166	iron-sulfur cluster assembly
HUO05_RS09370	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HUO05_RS09375	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HUO05_RS09385	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HUO05_RS09385	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HUO05_RS09395	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HUO05_RS09400	COG1074	ATP-dependent DNA helicase activity
HUO05_RS09405	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HUO05_RS09425	COG3141	response to X-ray
HUO05_RS09440	COG2171	N-acyltransferase activity
HUO05_RS09445	COG0584	glycerophosphoryl diester phosphodiesterase
HUO05_RS09450	COG2271	Major facilitator Superfamily
HUO05_RS09455	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HUO05_RS09460	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HUO05_RS09465	COG1349	DNA-binding transcription factor activity
HUO05_RS09470	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HUO05_RS09475	COG0598	Magnesium transport protein CorA
HUO05_RS09495	COG1609	Transcriptional regulator
HUO05_RS09500	COG0583	DNA-binding transcription factor activity
HUO05_RS09540	COG1022	Amp-dependent synthetase and ligase
HUO05_RS09550	COG0583	DNA-binding transcription factor activity
HUO05_RS09555	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HUO05_RS09560	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HUO05_RS09570	COG0560	Phosphoserine phosphatase
HUO05_RS09580	COG0813	purine-nucleoside phosphorylase activity
HUO05_RS09585	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HUO05_RS09590	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HUO05_RS09595	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HUO05_RS09600	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HUO05_RS09605	COG0084	hydrolase, TatD family'
HUO05_RS09635	COG3153	acetyltransferase
HUO05_RS09640	COG3154	lipid carrier protein
HUO05_RS09650	COG0826	peptidase U32
HUO05_RS09655	COG0826	peptidase U32
HUO05_RS09660	COG0534	Mate efflux family protein
HUO05_RS09675	COG1185	polyribonucleotide nucleotidyltransferase activity
HUO05_RS09680	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HUO05_RS09685	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HUO05_RS09690	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HUO05_RS09695	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HUO05_RS09700	COG0195	Participates in both transcription termination and antitermination
HUO05_RS09705	COG0779	Required for maturation of 30S ribosomal subunits
HUO05_RS09720	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HUO05_RS09725	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HUO05_RS09730	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HUO05_RS09735	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HUO05_RS09740	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HUO05_RS09745	COG1534	Rna-binding protein
HUO05_RS09750	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HUO05_RS09755	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HUO05_RS09760	COG2027	D-alanyl-D-alanine carboxypeptidase
HUO05_RS09770	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HUO05_RS09775	COG0739	heme binding
HUO05_RS09800	COG0628	permease
HUO05_RS09810	COG0784	Response regulator, receiver
HUO05_RS09810	COG2205	protein histidine kinase activity
HUO05_RS09815	COG0747	negative chemotaxis
HUO05_RS09825	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUO05_RS09830	COG0444	Belongs to the ABC transporter superfamily
HUO05_RS09835	COG4608	Belongs to the ABC transporter superfamily
HUO05_RS09845	COG2971	BadF BadG BcrA BcrD
HUO05_RS09860	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HUO05_RS09865	COG3842	ATPase activity
HUO05_RS09875	COG1840	ABC-type Fe3 transport system, periplasmic component
HUO05_RS09880	COG0004	ammonium transporteR
HUO05_RS09890	COG3112	Uncharacterised protein family (UPF0231)
HUO05_RS09895	COG1049	propionate catabolic process, 2-methylcitrate cycle
HUO05_RS09900	COG1752	Esterase of the alpha-beta hydrolase superfamily
HUO05_RS09905	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HUO05_RS09910	COG1643	Atp-dependent helicase
HUO05_RS09915	COG1489	DNA binding
HUO05_RS09925	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HUO05_RS09935	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HUO05_RS09940	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HUO05_RS09945	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HUO05_RS09950	COG1560	Kdo2-lipid A biosynthetic process
HUO05_RS09955	COG0842	Transport permease protein
HUO05_RS09960	COG1131	(ABC) transporter
HUO05_RS09965	COG0659	secondary active sulfate transmembrane transporter activity
HUO05_RS09970	COG0288	reversible hydration of carbon dioxide
HUO05_RS09985	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HUO05_RS09990	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUO05_RS09995	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HUO05_RS10000	COG2186	Transcriptional regulator
HUO05_RS10010	COG0157	Belongs to the NadC ModD family
HUO05_RS10020	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HUO05_RS10025	COG1459	type II secretion system
HUO05_RS10035	COG0237	dephospho-CoA kinase activity
HUO05_RS10040	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
HUO05_RS10045	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HUO05_RS10060	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HUO05_RS10065	COG0228	four-way junction DNA binding
HUO05_RS10070	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HUO05_RS10075	COG4137	Cytochrome C assembly protein
HUO05_RS10080	COG4536	flavin adenine dinucleotide binding
HUO05_RS10085	COG1854	S-ribosylhomocysteine lyase activity
HUO05_RS10095	COG2918	glutathione biosynthetic process
HUO05_RS10100	COG0612	Peptidase, M16
HUO05_RS10105	COG1238	metal cluster binding
HUO05_RS10115	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HUO05_RS10120	COG0511	ligase activity, forming carbon-carbon bonds
HUO05_RS10120	COG5016	pyruvate
HUO05_RS10125	COG3630	sodium ion export across plasma membrane
HUO05_RS10185	COG0527	aspartate kinase activity
HUO05_RS10190	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HUO05_RS10195	COG2137	regulation of response to DNA damage stimulus
HUO05_RS10200	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HUO05_RS10205	COG1546	Belongs to the CinA family
HUO05_RS10210	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HUO05_RS10215	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HUO05_RS10225	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HUO05_RS10230	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HUO05_RS10240	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HUO05_RS10245	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HUO05_RS10250	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HUO05_RS10255	COG0148	phosphopyruvate hydratase activity
HUO05_RS10260	COG0504	CTP synthase activity
HUO05_RS10265	COG3956	TIGRFAM MazG family protein
HUO05_RS10270	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HUO05_RS10285	COG0736	holo-[acyl-carrier-protein] synthase activity
HUO05_RS10290	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HUO05_RS10295	COG1381	Involved in DNA repair and RecF pathway recombination
HUO05_RS10300	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HUO05_RS10310	COG0681	Belongs to the peptidase S26 family
HUO05_RS10315	COG0481	GTPase activity
HUO05_RS10320	COG3086	response to oxidative stress
HUO05_RS10335	COG1595	DNA-templated transcription, initiation
HUO05_RS10340	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HUO05_RS10350	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HUO05_RS10370	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUO05_RS10375	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUO05_RS10380	COG3079	Belongs to the UPF0149 family
HUO05_RS10385	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HUO05_RS10395	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HUO05_RS10400	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HUO05_RS10405	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HUO05_RS10415	COG0583	DNA-binding transcription factor activity
HUO05_RS10430	COG0668	transmembrane transport
HUO05_RS10435	COG0191	fructose-bisphosphate aldolase activity
HUO05_RS10450	COG4771	TonB-dependent receptor
HUO05_RS10455	COG0583	DNA-binding transcription factor activity
HUO05_RS10460	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HUO05_RS10465	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HUO05_RS10480	COG2356	endonuclease I
HUO05_RS10485	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HUO05_RS10490	COG0189	ligase activity
HUO05_RS10495	COG1678	Uncharacterized ACR, COG1678
HUO05_RS10500	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HUO05_RS10515	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HUO05_RS10520	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HUO05_RS10525	COG0762	integral membrane protein
HUO05_RS10530	COG1872	DUF167
HUO05_RS10540	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HUO05_RS10545	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HUO05_RS10550	COG2066	Belongs to the glutaminase family
HUO05_RS10560	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HUO05_RS10570	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HUO05_RS10615	COG0840	transmembrane signaling receptor activity
HUO05_RS10690	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HUO05_RS10700	COG3394	polysaccharide catabolic process
HUO05_RS10705	COG1486	melibiose metabolic process
HUO05_RS10710	COG1447	Phosphotransferase system cellobiose-specific component IIA
HUO05_RS10715	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HUO05_RS10720	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HUO05_RS10725	COG0726	polysaccharide deacetylase
HUO05_RS10735	COG1028	Short-chain dehydrogenase reductase Sdr
HUO05_RS10750	COG0795	lipopolysaccharide-transporting ATPase activity
HUO05_RS10755	COG0795	lipopolysaccharide-transporting ATPase activity
HUO05_RS10760	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HUO05_RS10765	COG2927	DNA polymerase III (CHI subunit)
HUO05_RS10770	COG0525	valine-tRNA ligase activity
HUO05_RS10780	COG0456	acetyltransferase
HUO05_RS10810	COG0540	Belongs to the ATCase OTCase family
HUO05_RS10815	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
HUO05_RS10820	COG0251	oxidation-reduction process
HUO05_RS10825	COG0204	Acyl-transferase
HUO05_RS10830	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HUO05_RS10835	COG5007	Belongs to the BolA IbaG family
HUO05_RS10845	COG2854	intermembrane phospholipid transfer
HUO05_RS10850	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HUO05_RS10855	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HUO05_RS10860	COG1127	ABC transporter
HUO05_RS10870	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HUO05_RS10870	COG0517	IMP dehydrogenase activity
HUO05_RS10880	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HUO05_RS10885	COG1137	ATPase activity
HUO05_RS10895	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HUO05_RS10900	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HUO05_RS10905	COG1660	Displays ATPase and GTPase activities
HUO05_RS10910	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HUO05_RS10915	COG2239	Acts as a magnesium transporter
HUO05_RS10920	COG0312	modulator of DNA gyrase
HUO05_RS10925	COG3028	Belongs to the UPF0307 family
HUO05_RS10930	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HUO05_RS10935	COG0564	pseudouridine synthase activity
HUO05_RS10945	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HUO05_RS10950	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HUO05_RS10955	COG0312	modulator of DNA gyrase
HUO05_RS10965	COG3164	Protein of unknown function
HUO05_RS10970	COG1530	ribonuclease E activity
HUO05_RS10975	COG0424	maF-like protein
HUO05_RS10980	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HUO05_RS10985	COG1792	Involved in formation and maintenance of cell shape
HUO05_RS10990	COG1077	Cell shape determining protein MreB Mrl
HUO05_RS11035	COG1459	type II secretion system
HUO05_RS11040	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HUO05_RS11050	COG3409	Peptidoglycan-binding domain 1 protein
HUO05_RS11050	COG3267	Type II secretory pathway component ExeA
HUO05_RS11055	COG1450	Type ii and iii secretion system protein
HUO05_RS11075	COG2199	diguanylate cyclase activity
HUO05_RS11075	COG2200	EAL domain
HUO05_RS11080	COG0629	single-stranded DNA binding
HUO05_RS11095	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HUO05_RS11105	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HUO05_RS11110	COG0527	aspartate kinase activity
HUO05_RS11115	COG1410	methionine synthase
HUO05_RS11115	COG0646	methionine synthase
HUO05_RS11175	COG0175	sulfate reduction
HUO05_RS11180	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUO05_RS11185	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HUO05_RS11205	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HUO05_RS11210	COG0735	belongs to the Fur family
HUO05_RS11220	COG0166	Belongs to the GPI family
HUO05_RS11225	COG0432	Pfam Uncharacterised protein family UPF0047
HUO05_RS11230	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HUO05_RS11255	COG2965	DNA replication, synthesis of RNA primer
HUO05_RS11260	COG0360	Binds together with S18 to 16S ribosomal RNA
HUO05_RS11265	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HUO05_RS11270	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HUO05_RS11280	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HUO05_RS11285	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HUO05_RS11315	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HUO05_RS11325	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HUO05_RS11325	COG0678	peroxiredoxin activity
HUO05_RS11330	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HUO05_RS11340	COG0165	Argininosuccinate lyase
HUO05_RS11340	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HUO05_RS11345	COG0137	argininosuccinate synthase activity
HUO05_RS11355	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HUO05_RS11365	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HUO05_RS11375	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HUO05_RS11380	COG0527	aspartate kinase activity
HUO05_RS11380	COG0460	homoserine dehydrogenase
HUO05_RS11385	COG0626	cystathionine gamma-synthase activity
HUO05_RS11395	COG0281	malic enzyme
HUO05_RS11410	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HUO05_RS11415	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HUO05_RS11435	COG2923	Belongs to the DsrF TusC family
HUO05_RS11440	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HUO05_RS11445	COG2964	Protein conserved in bacteria
HUO05_RS11450	COG0545	Peptidyl-prolyl cis-trans isomerase
HUO05_RS11465	COG1446	asparaginase
HUO05_RS11470	COG1047	Peptidyl-prolyl cis-trans
HUO05_RS11485	COG2249	NAD(P)H dehydrogenase (quinone) activity
HUO05_RS11490	COG0488	(ABC) transporter
HUO05_RS11500	COG0429	hydrolase of the alpha beta-hydrolase fold
HUO05_RS11510	COG3954	Phosphoribulokinase
HUO05_RS11515	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUO05_RS11535	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HUO05_RS11540	COG0512	Glutamine amidotransferase of anthranilate synthase
HUO05_RS11555	COG0180	Tryptophanyl-tRNA synthetase
HUO05_RS11560	COG0546	phosphoglycolate phosphatase activity
HUO05_RS11565	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HUO05_RS11570	COG0557	exoribonuclease II activity
HUO05_RS11575	COG1959	2 iron, 2 sulfur cluster binding
HUO05_RS11580	COG1017	nitric oxide dioxygenase activity
HUO05_RS11580	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HUO05_RS11585	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HUO05_RS11590	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HUO05_RS11595	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HUO05_RS11600	COG0330	HflC and HflK could
HUO05_RS11605	COG0330	HflC and HflK could
HUO05_RS11610	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HUO05_RS11620	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HUO05_RS11625	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HUO05_RS11635	COG0802	atpase or kinase
HUO05_RS11640	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HUO05_RS11705	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HUO05_RS11710	COG1162	GTPase activity
HUO05_RS11715	COG0688	phosphatidylethanolamine metabolic process
HUO05_RS11720	COG0471	metal ion transport
HUO05_RS11720	COG3273	potassium ion transport
HUO05_RS11735	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HUO05_RS11740	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HUO05_RS11745	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HUO05_RS11750	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HUO05_RS11755	COG1045	serine acetyltransferase
HUO05_RS11760	COG4942	peptidase
HUO05_RS11780	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HUO05_RS11785	COG1053	succinate dehydrogenase
HUO05_RS11790	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HUO05_RS11795	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HUO05_RS11800	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
HUO05_RS11815	COG1509	lysine 2,3-aminomutase activity
HUO05_RS11820	COG1285	pathogenesis
HUO05_RS11830	COG0459	protein refolding
HUO05_RS11840	COG0534	Mate efflux family protein
HUO05_RS11845	COG0205	6-phosphofructokinase activity
HUO05_RS11855	COG3678	ATP-independent chaperone mediated protein folding
HUO05_RS11860	COG0745	RESPONSE REGULATOR receiver
HUO05_RS11865	COG2205	protein histidine kinase activity
HUO05_RS11875	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HUO05_RS11880	COG3030	protein affecting phage T7 exclusion by the F plasmid
HUO05_RS11885	COG1027	Aspartate ammonia-lyase
HUO05_RS11890	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HUO05_RS11895	COG4232	protein-disulfide reductase activity
HUO05_RS11905	COG3263	regulation of cellular component size
HUO05_RS11915	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HUO05_RS11940	COG2814	Major facilitator Superfamily
HUO05_RS11955	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HUO05_RS11960	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HUO05_RS11965	COG0511	ligase activity, forming carbon-carbon bonds
HUO05_RS11970	COG0439	Biotin carboxylase
HUO05_RS11975	COG2264	protein methyltransferase activity
HUO05_RS11980	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HUO05_RS11985	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HUO05_RS11995	COG0488	(ABC) transporter
HUO05_RS12045	COG1982	Orn Lys Arg decarboxylase major
HUO05_RS12050	COG0531	amino acid
HUO05_RS12055	COG3710	Transcriptional regulator
HUO05_RS12060	COG0789	Transcriptional regulator
HUO05_RS12065	COG0138	bifunctional purine biosynthesis protein purh
HUO05_RS12070	COG0151	Belongs to the GarS family
HUO05_RS12085	COG1253	flavin adenine dinucleotide binding
HUO05_RS12090	COG3068	Protein conserved in bacteria
HUO05_RS12100	COG1573	uracil-dna glycosylase
HUO05_RS12105	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HUO05_RS12110	COG2816	NAD+ diphosphatase activity
HUO05_RS12115	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
HUO05_RS12120	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HUO05_RS12125	COG0085	RNA polymerase activity
HUO05_RS12130	COG0222	ribosome binding
HUO05_RS12135	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HUO05_RS12150	COG0250	Participates in transcription elongation, termination and antitermination
HUO05_RS12155	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HUO05_RS12160	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HUO05_RS12190	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HUO05_RS12190	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HUO05_RS12195	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HUO05_RS12205	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HUO05_RS12280	COG4206	TonB-dependent receptor
HUO05_RS12300	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HUO05_RS12305	COG0534	Mate efflux family protein
HUO05_RS12310	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HUO05_RS12315	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HUO05_RS12320	COG2937	Belongs to the GPAT DAPAT family
HUO05_RS12325	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HUO05_RS12330	COG3161	chorismate lyase activity
HUO05_RS12335	COG1580	Controls the rotational direction of flagella during chemotaxis
HUO05_RS12340	COG0705	Rhomboid family
HUO05_RS12345	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HUO05_RS12355	COG2177	Part of the ABC transporter FtsEX involved in
HUO05_RS12360	COG2884	Cell division ATP-binding protein ftsE
HUO05_RS12365	COG0552	protein localization to endoplasmic reticulum
HUO05_RS12370	COG0742	ribosomal rna small subunit methyltransferase
HUO05_RS12380	COG2095	MarC family integral membrane protein
HUO05_RS12420	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HUO05_RS12425	COG0640	Transcriptional regulator
HUO05_RS12430	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HUO05_RS12435	COG1280	lysine exporter protein (LysE YggA)
HUO05_RS12440	COG2267	carboxylic ester hydrolase activity
HUO05_RS12445	COG0561	phosphatase activity
HUO05_RS12465	COG3287	FIST C domain
HUO05_RS12465	COG2200	EAL domain
HUO05_RS12465	COG2199	diguanylate cyclase activity
HUO05_RS12470	COG1011	Hydrolase
HUO05_RS12475	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HUO05_RS12490	COG0019	diaminopimelate decarboxylase activity
HUO05_RS12500	COG1965	Belongs to the frataxin family
HUO05_RS12505	COG3072	Adenylate cyclase
HUO05_RS12510	COG0181	hydroxymethylbilane synthase activity
HUO05_RS12515	COG1587	Uroporphyrinogen-III synthase
HUO05_RS12520	COG2959	enzyme of heme biosynthesis
HUO05_RS12525	COG3071	HemY protein
HUO05_RS12565	COG0633	Ferredoxin
HUO05_RS12570	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HUO05_RS12585	COG3118	belongs to the thioredoxin family
HUO05_RS12590	COG0513	Belongs to the DEAD box helicase family
HUO05_RS12595	COG0248	Ppx GppA phosphatase
HUO05_RS12605	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HUO05_RS12615	COG0514	ATP-dependent DNA helicase (RecQ)
HUO05_RS12620	COG2962	Rard protein
HUO05_RS12630	COG1280	lysine exporter protein (LysE YggA)
HUO05_RS12635	COG0405	Gamma-glutamyltransferase
HUO05_RS12640	COG0210	DNA helicase
HUO05_RS12650	COG3220	belongs to the UPF0276 family
HUO05_RS12680	COG0006	proline dipeptidase activity
HUO05_RS12680	COG0006	proline dipeptidase activity
HUO05_RS12695	COG2104	thiamine diphosphate biosynthetic process
HUO05_RS12700	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HUO05_RS12720	COG2132	Multicopper oxidase
HUO05_RS12770	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HUO05_RS12775	COG1739	Uncharacterized protein family UPF0029
HUO05_RS12785	COG0183	Belongs to the thiolase family
HUO05_RS12790	COG0604	alcohol dehydrogenase
HUO05_RS12805	COG0425	Belongs to the sulfur carrier protein TusA family
HUO05_RS12815	COG2119	membrane
HUO05_RS12830	COG0366	Alpha amylase catalytic
HUO05_RS12835	COG3977	Valine--pyruvate aminotransferase
HUO05_RS12840	COG0071	Belongs to the small heat shock protein (HSP20) family
HUO05_RS12850	COG0187	DNA topoisomerase II activity
HUO05_RS12860	COG0592	DNA-directed DNA polymerase activity
HUO05_RS12865	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HUO05_RS12880	COG1126	abc transporter atp-binding protein
HUO05_RS12890	COG0594	ribonuclease P activity
HUO05_RS12900	COG0706	membrane insertase activity
HUO05_RS12910	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HUO05_RS12915	COG0445	tRNA wobble uridine modification
HUO05_RS12920	COG0357	Ribosomal RNA small subunit methyltransferase G
HUO05_RS12925	COG1192	Involved in chromosome partitioning
HUO05_RS12930	COG1475	DNA binding
HUO05_RS12935	COG3312	ion transport
HUO05_RS12940	COG0356	it plays a direct role in the translocation of protons across the membrane
HUO05_RS12950	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HUO05_RS12955	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HUO05_RS12960	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HUO05_RS12965	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HUO05_RS12970	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HUO05_RS12975	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HUO05_RS12985	COG0765	amino acid transport
HUO05_RS12995	COG2814	Major facilitator Superfamily
HUO05_RS13000	COG0583	DNA-binding transcription factor activity
HUO05_RS13010	COG0129	dihydroxy-acid dehydratase activity
HUO05_RS13015	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HUO05_RS13020	COG3978	acetolactate synthase activity
HUO05_RS13030	COG0606	chelatase, subunit chli
HUO05_RS13040	COG0204	Acyl-transferase
HUO05_RS13045	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HUO05_RS13050	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HUO05_RS13060	COG3084	Protein conserved in bacteria
HUO05_RS13070	COG4326	sporulation control protein
HUO05_RS13075	COG1272	protein, Hemolysin III
HUO05_RS13085	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HUO05_RS13090	COG0569	domain protein
HUO05_RS13095	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HUO05_RS13095	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HUO05_RS13100	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HUO05_RS13105	COG0242	peptide deformylase activity
HUO05_RS13115	COG0758	DNA mediated transformation
HUO05_RS13120	COG2922	Belongs to the Smg family
HUO05_RS13125	COG0551	DNA topoisomerase type I activity
HUO05_RS13130	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HUO05_RS13135	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HUO05_RS13140	COG0009	L-threonylcarbamoyladenylate synthase
HUO05_RS13145	COG0408	coproporphyrinogen oxidase activity
HUO05_RS13160	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HUO05_RS13195	COG0583	DNA-binding transcription factor activity
HUO05_RS13200	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HUO05_RS13205	COG2960	long-chain fatty acid transporting porin activity
HUO05_RS13210	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HUO05_RS13215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HUO05_RS13270	COG4166	transmembrane transport
HUO05_RS13280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUO05_RS13290	COG1609	Transcriptional regulator
HUO05_RS13295	COG0583	DNA-binding transcription factor activity
HUO05_RS13315	COG0129	dihydroxy-acid dehydratase activity
HUO05_RS13320	COG3265	gluconokinase activity
HUO05_RS13325	COG2610	gluconate transmembrane transporter activity
HUO05_RS13330	COG0800	Aldolase
HUO05_RS13335	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HUO05_RS13340	COG0583	DNA-binding transcription factor activity
HUO05_RS13345	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HUO05_RS13350	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HUO05_RS13360	COG1522	sequence-specific DNA binding
HUO05_RS13365	COG5001	Diguanylate cyclase
HUO05_RS13365	COG5002	protein histidine kinase activity
HUO05_RS13370	COG0742	ribosomal rna small subunit methyltransferase
HUO05_RS13385	COG0589	response to stress
HUO05_RS13390	COG1528	Iron-storage protein
HUO05_RS13400	COG2081	HI0933 family
HUO05_RS13430	COG1597	lipid kinase activity
HUO05_RS13460	COG0628	permease
HUO05_RS13475	COG1322	Protein conserved in bacteria
HUO05_RS13480	COG2226	methyltransferase
HUO05_RS13485	COG3165	ubiquinone biosynthetic process from chorismate
HUO05_RS13490	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HUO05_RS13500	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HUO05_RS13505	COG0805	protein transport
HUO05_RS13510	COG0084	hydrolase, TatD family'
HUO05_RS13520	COG0456	acetyltransferase
HUO05_RS13525	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HUO05_RS13525	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HUO05_RS13530	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HUO05_RS13560	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HUO05_RS13570	COG2204	response regulator
HUO05_RS13575	COG3852	Histidine kinase
HUO05_RS13585	COG0174	glutamine synthetase
HUO05_RS13595	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HUO05_RS13605	COG1295	ribonuclease BN
HUO05_RS13610	COG1490	D-aminoacyl-tRNA deacylase activity
HUO05_RS13615	COG0456	acetyltransferase
HUO05_RS13625	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HUO05_RS13630	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HUO05_RS13635	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HUO05_RS13640	COG3031	protein transport across the cell outer membrane
HUO05_RS13650	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HUO05_RS13655	COG1459	type II secretion system
HUO05_RS13660	COG2165	general secretion pathway protein
HUO05_RS13665	COG2165	general secretion pathway protein
HUO05_RS13670	COG2165	general secretion pathway protein
HUO05_RS13675	COG4795	General secretion pathway protein
HUO05_RS13680	COG3156	type II secretion system protein K
HUO05_RS13685	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HUO05_RS13690	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HUO05_RS13700	COG1218	3'(2'),5'-bisphosphate nucleotidase
HUO05_RS13705	COG0494	nUDIX hydrolase
HUO05_RS13715	COG1040	competence protein
HUO05_RS13730	COG2183	response to ionizing radiation
HUO05_RS13740	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HUO05_RS13750	COG0745	RESPONSE REGULATOR receiver
HUO05_RS13755	COG2205	protein histidine kinase activity
HUO05_RS13760	COG2233	PERMEase
HUO05_RS13765	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HUO05_RS13770	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HUO05_RS13775	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HUO05_RS13780	COG1758	RNA polymerase activity
HUO05_RS13785	COG0194	GDP metabolic process
HUO05_RS13800	COG0848	biopolymer transport protein
HUO05_RS13805	COG0811	peptide transport
HUO05_RS13825	COG4174	ABC transporter (Permease)
HUO05_RS13830	COG4239	(ABC) transporter, permease
HUO05_RS13835	COG0747	negative chemotaxis
HUO05_RS13840	COG0444	Belongs to the ABC transporter superfamily
HUO05_RS13845	COG4608	Belongs to the ABC transporter superfamily
HUO05_RS13860	COG1561	YicC-like family, N-terminal region
HUO05_RS13865	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HUO05_RS13875	COG1560	Kdo2-lipid A biosynthetic process
HUO05_RS13880	COG1309	transcriptional regulator
HUO05_RS13885	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HUO05_RS13895	COG2003	Belongs to the UPF0758 family
HUO05_RS13920	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HUO05_RS13935	COG0463	Glycosyl transferase, family 2
HUO05_RS13940	COG0859	PFAM glycosyl transferase family 9
HUO05_RS13945	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HUO05_RS13950	COG3642	lipopolysaccharide core region biosynthetic process
HUO05_RS13960	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HUO05_RS14000	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HUO05_RS14005	COG1519	Transferase
HUO05_RS14010	COG0859	PFAM glycosyl transferase family 9
HUO05_RS14020	COG1560	Kdo2-lipid A biosynthetic process
HUO05_RS14030	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HUO05_RS14070	COG5039	Polysaccharide pyruvyl transferase
HUO05_RS14075	COG3306	glycosyltransferase involved in LPS biosynthesis
HUO05_RS14100	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HUO05_RS14110	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HUO05_RS14130	COG0438	transferase activity, transferring glycosyl groups
HUO05_RS14175	COG0149	triose-phosphate isomerase activity
HUO05_RS14205	COG1494	fructose-1,6-bisphosphatase
HUO05_RS14215	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HUO05_RS14220	COG1575	Belongs to the MenA family. Type 1 subfamily
HUO05_RS14225	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HUO05_RS14230	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HUO05_RS14240	COG1609	Transcriptional regulator
HUO05_RS14245	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HUO05_RS14250	COG0254	rRNA binding
HUO05_RS14260	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HUO05_RS14265	COG0088	Forms part of the polypeptide exit tunnel
HUO05_RS14275	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HUO05_RS14280	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HUO05_RS14285	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HUO05_RS14290	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HUO05_RS14300	COG0255	Belongs to the universal ribosomal protein uL29 family
HUO05_RS14305	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HUO05_RS14315	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HUO05_RS14320	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HUO05_RS14330	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HUO05_RS14335	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HUO05_RS14350	COG1841	ribosomal large subunit assembly
HUO05_RS14360	COG0201	protein transport
HUO05_RS14365	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HUO05_RS14370	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HUO05_RS14375	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HUO05_RS14385	COG0202	RNA polymerase activity
HUO05_RS14390	COG0203	ribosomal protein L17
HUO05_RS14405	COG0545	Peptidyl-prolyl cis-trans isomerase
HUO05_RS14415	COG2153	protein acetylation
HUO05_RS14420	COG0513	Belongs to the DEAD box helicase family
HUO05_RS14435	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HUO05_RS14435	COG1648	precorrin-2 dehydrogenase activity
HUO05_RS14440	COG0175	sulfate reduction
HUO05_RS14445	COG2895	sulfate adenylyltransferase (ATP) activity
HUO05_RS14450	COG0471	metal ion transport
HUO05_RS14450	COG3273	potassium ion transport
HUO05_RS14455	COG0529	Catalyzes the synthesis of activated sulfate
HUO05_RS14475	COG4181	ATPase activity
HUO05_RS14490	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HUO05_RS14500	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUO05_RS14505	COG0729	surface antigen
HUO05_RS14510	COG2911	Protein conserved in bacteria
HUO05_RS14515	COG2105	PFAM AIG2 family protein
HUO05_RS14525	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HUO05_RS14530	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HUO05_RS14535	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HUO05_RS14540	COG0163	prenyltransferase activity
HUO05_RS14545	COG4143	(ABC) transporter
HUO05_RS14550	COG1178	ABC-type Fe3 transport system permease component
HUO05_RS14555	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
HUO05_RS14560	COG0583	DNA-binding transcription factor activity
HUO05_RS14565	COG1902	pentaerythritol trinitrate reductase activity
HUO05_RS14580	COG2358	TRAP transporter, solute receptor (TAXI family
HUO05_RS14600	COG0142	geranyltranstransferase activity
HUO05_RS14605	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HUO05_RS14615	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HUO05_RS14620	COG2966	Psort location CytoplasmicMembrane, score
HUO05_RS14630	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HUO05_RS14635	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HUO05_RS14640	COG2967	ApaG domain
HUO05_RS14645	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HUO05_RS14650	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HUO05_RS14655	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HUO05_RS14660	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HUO05_RS14665	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HUO05_RS14685	COG0473	3-isopropylmalate dehydrogenase activity
HUO05_RS14690	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HUO05_RS14710	COG0583	DNA-binding transcription factor activity
HUO05_RS14715	COG1022	Amp-dependent synthetase and ligase
HUO05_RS14720	COG0028	Belongs to the TPP enzyme family
HUO05_RS14725	COG0440	acetolactate synthase activity
HUO05_RS14730	COG3706	GGDEF domain
HUO05_RS14740	COG0469	pyruvate kinase activity
HUO05_RS14745	COG1349	DNA-binding transcription factor activity
HUO05_RS14750	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HUO05_RS14760	COG2376	Dihydroxyacetone kinase
HUO05_RS14765	COG1461	Dihydroxyacetone kinase
HUO05_RS14780	COG3722	fumarate hydratase activity
HUO05_RS14790	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HUO05_RS14790	COG2213	PTS system mannitol-specific
HUO05_RS14825	COG0358	DNA primase activity
HUO05_RS14830	COG1610	YqeY-like protein
HUO05_RS14835	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HUO05_RS14840	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HUO05_RS14845	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HUO05_RS14850	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HUO05_RS14855	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HUO05_RS14860	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HUO05_RS14865	COG1968	undecaprenyl-diphosphatase activity
HUO05_RS14875	COG3267	Type II secretory pathway component ExeA
HUO05_RS14875	COG3409	Peptidoglycan-binding domain 1 protein
HUO05_RS14885	COG0405	Gamma-glutamyltransferase
HUO05_RS14890	COG4991	sh3 domain protein
HUO05_RS14895	COG0306	phosphate transporter
HUO05_RS14900	COG1392	Phosphate transport regulator
HUO05_RS14905	COG3025	triphosphatase activity
HUO05_RS14920	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HUO05_RS14925	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HUO05_RS14925	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HUO05_RS14930	COG1538	Outer membrane efflux protein
HUO05_RS14935	COG0494	nUDIX hydrolase
HUO05_RS14940	COG3151	Protein conserved in bacteria
HUO05_RS14950	COG3150	esterase
HUO05_RS14960	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HUO05_RS14965	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUO05_RS14975	COG3105	Protein conserved in bacteria
HUO05_RS14980	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HUO05_RS14990	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HUO05_RS14995	COG0723	plastoquinol--plastocyanin reductase activity
HUO05_RS15000	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HUO05_RS15005	COG2857	Cytochrome c1
HUO05_RS15010	COG0625	glutathione transferase activity
HUO05_RS15015	COG2969	positive regulation of protein catabolic process
HUO05_RS15020	COG2823	Periplasmic or secreted lipoprotein
HUO05_RS15025	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HUO05_RS15040	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HUO05_RS15055	COG3116	cell division
HUO05_RS15060	COG0768	penicillin binding
HUO05_RS15065	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HUO05_RS15070	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HUO05_RS15075	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HUO05_RS15080	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HUO05_RS15085	COG0772	Belongs to the SEDS family
HUO05_RS15100	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HUO05_RS15105	COG0849	cell division
HUO05_RS15110	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HUO05_RS15115	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HUO05_RS15125	COG0653	protein targeting
HUO05_RS15130	COG0494	nUDIX hydrolase
HUO05_RS15140	COG0505	Belongs to the CarA family
HUO05_RS15145	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HUO05_RS15160	COG0730	response to heat
HUO05_RS15165	COG0583	DNA-binding transcription factor activity
HUO05_RS15170	COG2860	membrane
HUO05_RS15185	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HUO05_RS15195	COG0493	'glutamate synthase
HUO05_RS15200	COG0067	glutamate synthase
HUO05_RS15200	COG0070	glutamate synthase
HUO05_RS15200	COG0069	glutamate synthase activity
HUO05_RS15210	COG0070	glutamate synthase
HUO05_RS15210	COG0069	glutamate synthase activity
HUO05_RS15210	COG0067	glutamate synthase
HUO05_RS15215	COG1242	4 iron, 4 sulfur cluster binding
HUO05_RS15220	COG5001	Diguanylate cyclase
HUO05_RS15220	COG3706	GGDEF domain
HUO05_RS15220	COG2203	Gaf domain
HUO05_RS15220	COG4251	negative regulation of phosphorylation
HUO05_RS15225	COG2198	Histidine kinase
HUO05_RS15225	COG5002	protein histidine kinase activity
HUO05_RS15225	COG0784	Response regulator, receiver
HUO05_RS15235	COG0745	RESPONSE REGULATOR receiver
HUO05_RS15245	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HUO05_RS15265	COG0083	homoserine kinase activity
HUO05_RS15270	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HUO05_RS15280	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
HUO05_RS15285	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HUO05_RS15290	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HUO05_RS15305	COG1115	amino acid carrier protein
HUO05_RS15310	COG3022	response to hydroperoxide
HUO05_RS15315	COG0513	Belongs to the DEAD box helicase family
HUO05_RS15320	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HUO05_RS15330	COG0716	FMN binding
HUO05_RS15335	COG4974	Belongs to the 'phage' integrase family
HUO05_RS15340	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HUO05_RS15345	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HUO05_RS15360	COG2204	response regulator
HUO05_RS15370	COG0667	Aldo Keto reductase
HUO05_RS15395	COG0730	response to heat
HUO05_RS15405	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HUO05_RS15415	COG1283	sodium-dependent phosphate transmembrane transporter activity
HUO05_RS15420	COG0583	DNA-binding transcription factor activity
HUO05_RS15425	COG0640	Transcriptional regulator
HUO05_RS15430	COG0268	Binds directly to 16S ribosomal RNA
HUO05_RS15435	COG0728	peptidoglycan biosynthetic process
HUO05_RS15440	COG0196	riboflavin kinase activity
HUO05_RS15455	COG1047	Peptidyl-prolyl cis-trans
HUO05_RS15460	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HUO05_RS15470	COG3279	Response regulator of the LytR AlgR family
HUO05_RS15475	COG3275	phosphorelay sensor kinase activity
HUO05_RS15480	COG1966	Carbon starvation protein
HUO05_RS15500	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HUO05_RS15505	COG1472	Belongs to the glycosyl hydrolase 3 family
HUO05_RS15510	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HUO05_RS15515	COG0287	Prephenate dehydrogenase
HUO05_RS15515	COG1605	Chorismate mutase
HUO05_RS15520	COG0739	heme binding
HUO05_RS15530	COG0488	(ABC) transporter
HUO05_RS15540	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
HUO05_RS15545	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
HUO05_RS15550	COG0077	Prephenate dehydratase
HUO05_RS15550	COG1605	Chorismate mutase
HUO05_RS15555	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HUO05_RS15565	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HUO05_RS15570	COG0564	pseudouridine synthase activity
HUO05_RS15580	COG0542	response to heat
HUO05_RS15610	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUO05_RS15615	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
HUO05_RS15625	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HUO05_RS15630	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUO05_RS15635	COG1012	belongs to the aldehyde dehydrogenase family
HUO05_RS15650	COG0583	DNA-binding transcription factor activity
HUO05_RS15655	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HUO05_RS15660	COG0569	domain protein
HUO05_RS15670	COG2205	protein histidine kinase activity
HUO05_RS15670	COG2205	protein histidine kinase activity
HUO05_RS15675	COG1132	(ABC) transporter
HUO05_RS15680	COG4774	siderophore transport
HUO05_RS15685	COG1120	ATPase activity
HUO05_RS15690	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HUO05_RS15725	COG2197	response regulator
HUO05_RS15740	COG0714	Associated with various cellular activities
HUO05_RS15760	COG2304	oxidoreductase activity
HUO05_RS15775	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HUO05_RS15780	COG0581	inorganic phosphate transmembrane transporter activity
HUO05_RS15785	COG0573	inorganic phosphate transmembrane transporter activity
HUO05_RS15815	COG4771	TonB-dependent receptor
HUO05_RS15820	COG1770	oligopeptidase
HUO05_RS15825	COG0513	Belongs to the DEAD box helicase family
HUO05_RS15835	COG1388	LysM domain
HUO05_RS15835	COG1376	ErfK ybiS ycfS ynhG family protein
HUO05_RS15840	COG0415	Belongs to the DNA photolyase family
HUO05_RS15845	COG0789	Transcriptional regulator
HUO05_RS15850	COG3272	Protein of unknown function (DUF1722)
HUO05_RS15855	COG0813	purine-nucleoside phosphorylase activity
HUO05_RS15870	COG3706	GGDEF domain
HUO05_RS15880	COG1566	PFAM secretion protein HlyD family protein
HUO05_RS15885	COG4720	Psort location CytoplasmicMembrane, score
HUO05_RS15890	COG1122	ATPase activity
HUO05_RS15910	COG0348	domain, Protein
HUO05_RS15915	COG0437	4 iron, 4 sulfur cluster binding
HUO05_RS15920	COG1247	-acetyltransferase
HUO05_RS15940	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HUO05_RS15945	COG0840	transmembrane signaling receptor activity
HUO05_RS15950	COG1067	ATP-dependent peptidase activity
HUO05_RS15960	COG4172	Belongs to the ABC transporter superfamily
HUO05_RS15965	COG1505	serine-type exopeptidase activity
HUO05_RS15970	COG0583	DNA-binding transcription factor activity
HUO05_RS15975	COG1620	l-lactate permease
HUO05_RS15980	COG1304	FMN binding
HUO05_RS15990	COG0668	transmembrane transport
HUO05_RS16025	COG1063	alcohol dehydrogenase
HUO05_RS16030	COG0156	8-amino-7-oxononanoate synthase activity
HUO05_RS16035	COG5001	Diguanylate cyclase
HUO05_RS16035	COG3300	MHYT domain
HUO05_RS16060	COG0745	RESPONSE REGULATOR receiver
HUO05_RS16085	COG0346	lactoylglutathione lyase activity
HUO05_RS16145	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HUO05_RS16185	COG1987	bacterial-type flagellum assembly
HUO05_RS16195	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HUO05_RS16210	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HUO05_RS16220	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HUO05_RS16225	COG1516	flagellar protein fliS
HUO05_RS16240	COG1580	Controls the rotational direction of flagella during chemotaxis
HUO05_RS16245	COG1191	sigma factor activity
HUO05_RS16250	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HUO05_RS16255	COG1360	Flagellar Motor Protein
HUO05_RS16285	COG1882	Formate acetyltransferase
HUO05_RS16290	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HUO05_RS16295	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HUO05_RS16310	COG2205	protein histidine kinase activity
HUO05_RS16315	COG0745	RESPONSE REGULATOR receiver
HUO05_RS16325	COG0454	-acetyltransferase
HUO05_RS16335	COG2814	Major facilitator Superfamily
HUO05_RS16375	COG0628	permease
HUO05_RS16380	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HUO05_RS16400	COG4628	conserved protein (DUF2132)
HUO05_RS16405	COG0583	DNA-binding transcription factor activity
HUO05_RS16430	COG1686	Belongs to the peptidase S11 family
HUO05_RS16450	COG0415	Belongs to the DNA photolyase family
HUO05_RS16455	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HUO05_RS16460	COG3397	chitin binding
HUO05_RS16465	COG4667	esterase of the alpha-beta hydrolase superfamily
HUO05_RS16470	COG2095	MarC family integral membrane protein
HUO05_RS16485	COG1596	polysaccharide export
HUO05_RS16490	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HUO05_RS16510	COG0583	DNA-binding transcription factor activity
HUO05_RS16520	COG1301	dicarboxylic acid transport
HUO05_RS16525	COG3339	Conserved Protein
HUO05_RS16535	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUO05_RS16540	COG0700	Nucleoside recognition
HUO05_RS16545	COG3366	ferrous iron transmembrane transporter activity
HUO05_RS16560	COG0366	Alpha amylase catalytic
HUO05_RS16565	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HUO05_RS16570	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HUO05_RS16575	COG1640	4-alpha-glucanotransferase
HUO05_RS16580	COG0058	SHG alpha-glucan phosphorylase activity
HUO05_RS16585	COG2909	trisaccharide binding
HUO05_RS16600	COG1999	signal sequence binding
HUO05_RS16605	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HUO05_RS16605	COG1263	PTS System
HUO05_RS16610	COG1162	GTPase activity
HUO05_RS16615	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HUO05_RS16620	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HUO05_RS16630	COG0531	amino acid
HUO05_RS16635	COG1982	Orn Lys Arg decarboxylase major
HUO05_RS16655	COG2356	endonuclease I
HUO05_RS16675	COG4580	involved in the transport of maltose and maltodextrins
HUO05_RS16685	COG1760	l-serine dehydratase
HUO05_RS16725	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HUO05_RS16735	COG1609	Transcriptional regulator
HUO05_RS16740	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HUO05_RS16765	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HUO05_RS16770	COG1609	Transcriptional regulator
HUO05_RS16780	COG2814	Major facilitator Superfamily
HUO05_RS16795	COG0739	heme binding
HUO05_RS16805	COG0612	Peptidase, M16
HUO05_RS16810	COG0840	transmembrane signaling receptor activity
HUO05_RS16815	COG1120	ATPase activity
HUO05_RS16820	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUO05_RS16825	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUO05_RS16830	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HUO05_RS16835	COG4772	TonB-dependent receptor
HUO05_RS16860	COG4264	IucA IucC family
HUO05_RS16865	COG0019	diaminopimelate decarboxylase activity
HUO05_RS16870	COG1653	transport
HUO05_RS16880	COG0745	RESPONSE REGULATOR receiver
HUO05_RS16905	COG1136	(ABC) transporter
HUO05_RS16945	COG1764	response to oxidative stress
HUO05_RS16950	COG1846	Transcriptional regulator
HUO05_RS16960	COG3634	alkyl hydroperoxide reductase activity
HUO05_RS17005	COG2258	MOSC domain
HUO05_RS17010	COG0513	Belongs to the DEAD box helicase family
HUO05_RS17020	COG1132	(ABC) transporter
HUO05_RS17055	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HUO05_RS17080	COG0259	pyridoxamine-phosphate oxidase activity
HUO05_RS17125	COG4166	transmembrane transport
HUO05_RS17140	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HUO05_RS17145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HUO05_RS17145	COG1263	PTS System
HUO05_RS17150	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HUO05_RS17155	COG3340	Belongs to the peptidase S51 family
HUO05_RS17175	COG1444	tRNA N-acetyltransferase activity
HUO05_RS17200	COG4608	Belongs to the ABC transporter superfamily
HUO05_RS17205	COG0444	Belongs to the ABC transporter superfamily
HUO05_RS17215	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HUO05_RS17215	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
HUO05_RS17240	COG0772	Belongs to the SEDS family
HUO05_RS17250	COG1136	(ABC) transporter
HUO05_RS17270	COG3275	phosphorelay sensor kinase activity
HUO05_RS17275	COG3279	Response regulator of the LytR AlgR family
HUO05_RS17285	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HUO05_RS17305	COG0786	glutamate:sodium symporter activity
HUO05_RS17315	COG1131	(ABC) transporter
HUO05_RS17320	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUO05_RS17325	COG0786	glutamate:sodium symporter activity
HUO05_RS17335	COG0363	glucosamine-6-phosphate deaminase activity
HUO05_RS17355	COG1741	Belongs to the pirin family
HUO05_RS17360	COG2259	Doxx family
HUO05_RS17370	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HUO05_RS17370	COG2169	Transcriptional regulator
HUO05_RS17375	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HUO05_RS17385	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HUO05_RS17410	COG0596	Alpha beta hydrolase
HUO05_RS17425	COG3123	guanosine phosphorylase activity
HUO05_RS17440	COG0534	Mate efflux family protein
HUO05_RS17445	COG0564	pseudouridine synthase activity
HUO05_RS17460	COG0583	DNA-binding transcription factor activity
HUO05_RS17465	COG0561	phosphatase activity
HUO05_RS17475	COG2199	diguanylate cyclase activity
HUO05_RS17490	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HUO05_RS17495	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HUO05_RS17500	COG0583	DNA-binding transcription factor activity
HUO05_RS17505	COG2375	cellular response to nickel ion
HUO05_RS17535	COG1357	PFAM Pentapeptide repeats (8 copies)
HUO05_RS17540	COG3047	cAMP biosynthetic process
HUO05_RS17600	COG3835	regulator
HUO05_RS17605	COG2610	gluconate transmembrane transporter activity
HUO05_RS17610	COG1929	Belongs to the glycerate kinase type-1 family
HUO05_RS17615	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUO05_RS17635	COG0456	acetyltransferase
HUO05_RS17650	COG1028	Short-chain dehydrogenase reductase Sdr
HUO05_RS17655	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HUO05_RS17660	COG3005	denitrification pathway
HUO05_RS17665	COG0243	molybdopterin cofactor binding
HUO05_RS17675	COG0352	thiamine-phosphate diphosphorylase activity
HUO05_RS17680	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HUO05_RS17685	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HUO05_RS17690	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HUO05_RS17695	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUO05_RS17700	COG1116	anion transmembrane transporter activity
HUO05_RS17705	COG0351	phosphomethylpyrimidine kinase
HUO05_RS17715	COG0312	modulator of DNA gyrase
HUO05_RS17720	COG1901	pseudouridine methyltransferase
HUO05_RS17780	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HUO05_RS17790	COG0584	glycerophosphoryl diester phosphodiesterase
HUO05_RS17795	COG0745	RESPONSE REGULATOR receiver
HUO05_RS17815	COG0811	peptide transport
HUO05_RS17820	COG0811	peptide transport
HUO05_RS17825	COG0848	biopolymer transport protein
HUO05_RS17870	COG0803	Belongs to the bacterial solute-binding protein 9 family
HUO05_RS17875	COG1121	(ABC) transporter
HUO05_RS17880	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HUO05_RS17895	COG1770	oligopeptidase
HUO05_RS17900	COG2814	Major facilitator Superfamily
HUO05_RS17905	COG0010	Belongs to the arginase family
HUO05_RS17910	COG1166	arginine decarboxylase activity
HUO05_RS17920	COG4067	protein conserved in archaea
HUO05_RS17920	COG0189	ligase activity
HUO05_RS17925	COG0189	ligase activity
HUO05_RS17945	COG0583	DNA-binding transcription factor activity
HUO05_RS17965	COG4191	Histidine kinase
HUO05_RS17975	COG3706	GGDEF domain
HUO05_RS17995	COG0579	oxidoreductase
HUO05_RS18000	COG3179	chitinase
HUO05_RS18015	COG1294	oxidase, subunit
HUO05_RS18020	COG1271	oxidase subunit
HUO05_RS18030	COG3033	Beta-eliminating lyase
HUO05_RS18045	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HUO05_RS18060	COG3706	GGDEF domain
HUO05_RS18075	COG3706	GGDEF domain
HUO05_RS18080	COG0415	Belongs to the DNA photolyase family
HUO05_RS18085	COG3046	protein related to deoxyribodipyrimidine photolyase
HUO05_RS18100	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUO05_RS18100	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUO05_RS18105	COG1765	OsmC-like protein
HUO05_RS18110	COG0110	maltose O-acetyltransferase activity
HUO05_RS18145	COG1011	Hydrolase
HUO05_RS18160	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HUO05_RS18165	COG3338	carbonate dehydratase activity
HUO05_RS18170	COG2067	long-chain fatty acid transport protein
HUO05_RS18175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HUO05_RS18180	COG1136	(ABC) transporter
HUO05_RS18180	COG0577	efflux transmembrane transporter activity
HUO05_RS18195	COG1309	transcriptional regulator
HUO05_RS18200	COG3240	lipase activity
HUO05_RS18230	COG1609	Transcriptional regulator
HUO05_RS18250	COG1840	ABC-type Fe3 transport system, periplasmic component
HUO05_RS18255	COG3842	ATPase activity
HUO05_RS18280	COG2990	Protein conserved in bacteria
HUO05_RS18290	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HUO05_RS18295	COG2866	Carboxypeptidase
HUO05_RS18305	COG0583	DNA-binding transcription factor activity
HUO05_RS18320	COG1760	l-serine dehydratase
HUO05_RS18340	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HUO05_RS18345	COG0741	lytic transglycosylase activity
HUO05_RS18365	COG1815	bacterial-type flagellum-dependent cell motility
HUO05_RS18370	COG1558	bacterial-type flagellum-dependent cell motility
HUO05_RS18385	COG4787	bacterial-type flagellum-dependent cell motility
HUO05_RS18390	COG4786	Flagellar basal body rod
HUO05_RS18395	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HUO05_RS18400	COG1706	bacterial-type flagellum-dependent cell motility
HUO05_RS18410	COG1256	bacterial-type flagellum assembly
HUO05_RS18410	COG4786	Flagellar basal body rod
HUO05_RS18435	COG1304	FMN binding
HUO05_RS18450	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HUO05_RS18455	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HUO05_RS18460	COG0459	protein refolding
HUO05_RS18470	COG1280	lysine exporter protein (LysE YggA)
HUO05_RS18490	COG1309	transcriptional regulator
HUO05_RS18500	COG4303	Ethanolamine ammonia lyase large subunit
HUO05_RS18505	COG4302	ethanolamine ammonia-lyase activity
HUO05_RS18510	COG0531	amino acid
HUO05_RS18525	COG1349	DNA-binding transcription factor activity
HUO05_RS18540	COG1335	isochorismatase
HUO05_RS18550	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HUO05_RS18575	COG0583	DNA-binding transcription factor activity
HUO05_RS18590	COG3713	MltA-interacting MipA family protein
HUO05_RS18595	COG3015	lipoprotein NlpE involved in copper resistance
HUO05_RS18600	COG4175	Glycine betaine
HUO05_RS18600	COG3448	diguanylate cyclase activity
HUO05_RS18605	COG4176	ABC-type proline glycine betaine transport system permease component
HUO05_RS18610	COG1342	Belongs to the UPF0251 family
HUO05_RS18640	COG4948	Mandelate Racemase Muconate Lactonizing
HUO05_RS18650	COG0583	DNA-binding transcription factor activity
HUO05_RS18680	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HUO05_RS18685	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HUO05_RS18715	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HUO05_RS18735	COG3842	ATPase activity
HUO05_RS18765	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HUO05_RS18790	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HUO05_RS18795	COG2197	response regulator
HUO05_RS18810	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HUO05_RS18815	COG0252	asparaginase activity
HUO05_RS18825	COG0583	DNA-binding transcription factor activity
HUO05_RS18840	COG3122	Protein conserved in bacteria
HUO05_RS18845	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HUO05_RS18850	COG1012	belongs to the aldehyde dehydrogenase family
HUO05_RS18855	COG1522	sequence-specific DNA binding
HUO05_RS18860	COG3608	succinylglutamate desuccinylase aspartoacylase
HUO05_RS18865	COG0006	proline dipeptidase activity
HUO05_RS18870	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUO05_RS18880	COG1028	Short-chain dehydrogenase reductase Sdr
HUO05_RS18890	COG1063	alcohol dehydrogenase
HUO05_RS18895	COG1902	pentaerythritol trinitrate reductase activity
HUO05_RS18910	COG0583	DNA-binding transcription factor activity
HUO05_RS18920	COG0513	Belongs to the DEAD box helicase family
HUO05_RS18940	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUO05_RS18945	COG2207	Transcriptional regulator
HUO05_RS18945	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HUO05_RS18950	COG0583	DNA-binding transcription factor activity
HUO05_RS18955	COG0300	oxidoreductase activity
HUO05_RS18970	COG3746	phosphate-selective porin O and P
HUO05_RS18985	COG1028	Short-chain dehydrogenase reductase Sdr
HUO05_RS19005	COG1263	PTS System
HUO05_RS19005	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HUO05_RS19010	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUO05_RS19015	COG1621	beta-fructofuranosidase activity
HUO05_RS19020	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HUO05_RS19030	COG0625	glutathione transferase activity
HUO05_RS19035	COG1686	Belongs to the peptidase S11 family
HUO05_RS19045	COG0678	peroxiredoxin activity
HUO05_RS19045	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HUO05_RS19050	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HUO05_RS19065	COG1278	Cold shock
HUO05_RS19070	COG1741	Belongs to the pirin family
HUO05_RS19075	COG4667	esterase of the alpha-beta hydrolase superfamily
HUO05_RS19095	COG2194	sulfuric ester hydrolase activity
HUO05_RS19100	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HUO05_RS19110	COG2205	protein histidine kinase activity
HUO05_RS19115	COG0745	RESPONSE REGULATOR receiver
HUO05_RS19130	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HUO05_RS19150	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HUO05_RS19160	COG2814	Major facilitator Superfamily
HUO05_RS19170	COG1418	mRNA catabolic process
HUO05_RS19175	COG0402	S-adenosylhomocysteine deaminase activity
HUO05_RS19180	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HUO05_RS19185	COG2239	Acts as a magnesium transporter
HUO05_RS19190	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HUO05_RS19195	COG1566	PFAM secretion protein HlyD family protein
HUO05_RS19220	COG0745	RESPONSE REGULATOR receiver
HUO05_RS19225	COG2205	protein histidine kinase activity
HUO05_RS19240	COG0531	amino acid
HUO05_RS19250	COG0583	DNA-binding transcription factor activity
HUO05_RS19275	COG0784	Response regulator, receiver
HUO05_RS19275	COG2205	protein histidine kinase activity
HUO05_RS19275	COG5002	protein histidine kinase activity
HUO05_RS19295	COG3132	Protein of unknown function, DUF480
HUO05_RS19300	COG2827	Endonuclease containing a URI domain
HUO05_RS19305	COG1879	ABC-type sugar transport system periplasmic component
HUO05_RS19310	COG0784	Response regulator, receiver
HUO05_RS19310	COG2205	protein histidine kinase activity
HUO05_RS19315	COG1846	Transcriptional regulator
HUO05_RS19365	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HUO05_RS19370	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HUO05_RS19380	COG1280	lysine exporter protein (LysE YggA)
HUO05_RS19390	COG0183	Belongs to the thiolase family
HUO05_RS19400	COG3243	poly(R)-hydroxyalkanoic acid synthase
HUO05_RS19410	COG3005	denitrification pathway
HUO05_RS19420	COG0243	molybdopterin cofactor binding
HUO05_RS19430	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HUO05_RS19435	COG3850	Histidine kinase
HUO05_RS19440	COG2197	response regulator
HUO05_RS19455	COG2195	Cleaves the N-terminal amino acid of tripeptides
HUO05_RS19475	COG0840	transmembrane signaling receptor activity
HUO05_RS19485	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUO05_RS19495	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HUO05_RS19500	COG2814	Major facilitator Superfamily
HUO05_RS19505	COG0840	transmembrane signaling receptor activity
HUO05_RS19510	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HUO05_RS19515	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HUO05_RS19525	COG2897	thiosulfate sulfurtransferase activity
HUO05_RS19560	COG0038	chloride channel
HUO05_RS19575	COG4989	oxidoreductase activity
HUO05_RS19590	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HUO05_RS19590	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HUO05_RS19600	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
HUO05_RS19645	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUO05_RS19660	COG0739	heme binding
HUO05_RS19700	COG3501	Rhs element vgr protein
HUO05_RS19760	COG1522	sequence-specific DNA binding
HUO05_RS19825	COG2814	Major facilitator Superfamily
HUO05_RS19835	COG0583	DNA-binding transcription factor activity
HUO05_RS19840	COG4221	oxidoreductase activity
HUO05_RS19845	COG0589	response to stress
HUO05_RS19855	COG2111	Na H antiporter
HUO05_RS19855	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HUO05_RS19860	COG1006	Multisubunit Na H antiporter MnhC subunit
HUO05_RS19875	COG2212	antiporter activity
HUO05_RS19880	COG1320	monovalent cation:proton antiporter activity
HUO05_RS19885	COG2188	Transcriptional regulator
HUO05_RS19890	COG1486	melibiose metabolic process
HUO05_RS19895	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HUO05_RS19895	COG1263	PTS System
HUO05_RS19900	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HUO05_RS19925	COG1022	Amp-dependent synthetase and ligase
HUO05_RS19955	COG0500	methyltransferase
HUO05_RS19960	COG1028	Short-chain dehydrogenase reductase Sdr
HUO05_RS19970	COG3527	Alpha-acetolactate decarboxylase
HUO05_RS19980	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUO05_RS19995	COG1294	oxidase, subunit
HUO05_RS20000	COG1271	oxidase subunit
HUO05_RS20005	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUO05_RS20010	COG0110	maltose O-acetyltransferase activity
HUO05_RS20015	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HUO05_RS20015	COG3264	Mechanosensitive ion channel
HUO05_RS20030	COG4770	biotin carboxylase activity
HUO05_RS20040	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HUO05_RS20045	COG1960	acyl-CoA dehydrogenase activity
HUO05_RS20055	COG0183	Belongs to the thiolase family
HUO05_RS20065	COG1960	acyl-CoA dehydrogenase activity
HUO05_RS20070	COG1024	Enoyl-CoA hydratase
HUO05_RS20085	COG1028	Short-chain dehydrogenase reductase Sdr
HUO05_RS20095	COG1309	transcriptional regulator
HUO05_RS20100	COG1012	belongs to the aldehyde dehydrogenase family
HUO05_RS20115	COG4176	ABC-type proline glycine betaine transport system permease component
HUO05_RS20120	COG4175	Glycine betaine
HUO05_RS20120	COG0517	IMP dehydrogenase activity
HUO05_RS20135	COG0330	HflC and HflK could
HUO05_RS20150	COG0784	Response regulator, receiver
HUO05_RS20150	COG2205	protein histidine kinase activity
HUO05_RS20160	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HUO05_RS20210	COG5001	Diguanylate cyclase
HUO05_RS20215	COG1869	D-ribose catabolic process
HUO05_RS20220	COG1129	ABC transporter
HUO05_RS20225	COG1172	Belongs to the binding-protein-dependent transport system permease family
HUO05_RS20230	COG1879	ABC-type sugar transport system periplasmic component
HUO05_RS20235	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUO05_RS20240	COG1609	Transcriptional regulator
HUO05_RS20250	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HUO05_RS20260	COG4607	ABC-type enterochelin transport system periplasmic component
HUO05_RS20265	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUO05_RS20270	COG4605	iron ion homeostasis
HUO05_RS20275	COG4604	ABC transporter, ATP-binding protein
HUO05_RS20280	COG0789	Transcriptional regulator
HUO05_RS20290	COG4771	TonB-dependent receptor
HUO05_RS20290	COG1629	transport
HUO05_RS20320	COG1289	transmembrane transporter activity
HUO05_RS20325	COG0210	DNA helicase
HUO05_RS20330	COG1803	Methylglyoxal synthase
HUO05_RS20335	COG1879	ABC-type sugar transport system periplasmic component
HUO05_RS20340	COG2205	protein histidine kinase activity
HUO05_RS20340	COG2198	Histidine kinase
HUO05_RS20340	COG0784	Response regulator, receiver
HUO05_RS20355	COG0745	RESPONSE REGULATOR receiver
HUO05_RS20360	COG3119	arylsulfatase activity
HUO05_RS20370	COG3119	arylsulfatase activity
HUO05_RS20375	COG0641	radical SAM
HUO05_RS20380	COG0714	Associated with various cellular activities
HUO05_RS20410	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HUO05_RS20415	COG0583	DNA-binding transcription factor activity
HUO05_RS20420	COG1597	lipid kinase activity
HUO05_RS20425	COG3111	PFAM Bacterial OB fold (BOF) protein
HUO05_RS20450	COG3069	C4-dicarboxylate transmembrane transporter activity
HUO05_RS20460	COG0456	acetyltransferase
HUO05_RS20460	COG1214	PFAM Peptidase M22, glycoprotease
HUO05_RS20480	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HUO05_RS20515	COG2003	Belongs to the UPF0758 family
HUO05_RS20520	COG0328	RNA-DNA hybrid ribonuclease activity
HUO05_RS20555	COG0494	nUDIX hydrolase
HUO05_RS20575	COG1715	Restriction endonuclease
HUO05_RS20580	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
HUO05_RS20590	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HUO05_RS20620	COG0582	viral genome integration into host DNA
HUO05_RS20630	COG3300	MHYT domain
HUO05_RS20630	COG5001	Diguanylate cyclase
HUO05_RS20635	COG2197	response regulator
HUO05_RS20640	COG3706	GGDEF domain
HUO05_RS20650	COG2197	response regulator
HUO05_RS20655	COG0784	Response regulator, receiver
HUO05_RS20655	COG0835	chemotaxis
HUO05_RS20670	COG2962	Rard protein
HUO05_RS20690	COG2076	Multidrug Resistance protein
HUO05_RS20725	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HUO05_RS20730	COG5642	Protein of unknown function (DUF2384)
HUO05_RS20750	COG1902	pentaerythritol trinitrate reductase activity
HUO05_RS20755	COG0346	lactoylglutathione lyase activity
HUO05_RS20775	COG2239	Acts as a magnesium transporter
HUO05_RS20805	COG0242	peptide deformylase activity
HUO05_RS20845	COG2176	DNA-directed DNA polymerase activity
HUO05_RS20905	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HUO05_RS20910	COG0697	spore germination
HUO05_RS20915	COG0583	DNA-binding transcription factor activity
HUO05_RS20920	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUO05_RS20925	COG0346	lactoylglutathione lyase activity
HUO05_RS20935	COG0509	glycine decarboxylation via glycine cleavage system
HUO05_RS20940	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HUO05_RS20950	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HUO05_RS20980	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HUO05_RS20980	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HUO05_RS20980	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HUO05_RS20985	COG1105	Belongs to the carbohydrate kinase PfkB family
HUO05_RS20990	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HUO05_RS20990	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HUO05_RS20995	COG1609	Transcriptional regulator
HUO05_RS21010	COG2203	Gaf domain
HUO05_RS21010	COG2199	diguanylate cyclase activity
HUO05_RS21010	COG2200	EAL domain
HUO05_RS21015	COG0765	amino acid transport
HUO05_RS21020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUO05_RS21025	COG0765	amino acid transport
HUO05_RS21030	COG1126	abc transporter atp-binding protein
HUO05_RS21040	COG1979	alcohol dehydrogenase
HUO05_RS21045	COG2207	Transcriptional regulator
HUO05_RS21055	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HUO05_RS21060	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HUO05_RS21065	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUO05_RS21080	COG0546	phosphoglycolate phosphatase activity
HUO05_RS21085	COG0840	transmembrane signaling receptor activity
HUO05_RS21090	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
HUO05_RS21095	COG0513	Belongs to the DEAD box helicase family
HUO05_RS21115	COG3038	cytochrome b561
HUO05_RS21120	COG2353	YceI-like domain
HUO05_RS21125	COG2116	formate transmembrane transporter activity
HUO05_RS21130	COG0583	DNA-binding transcription factor activity
HUO05_RS21140	COG3593	DNA synthesis involved in DNA repair
HUO05_RS21145	COG0737	Belongs to the 5'-nucleotidase family
HUO05_RS21170	COG2267	carboxylic ester hydrolase activity
HUO05_RS21175	COG2067	long-chain fatty acid transport protein
HUO05_RS21190	COG2050	protein possibly involved in aromatic compounds catabolism
HUO05_RS21200	COG4533	DNA binding
HUO05_RS21235	COG5001	Diguanylate cyclase
HUO05_RS21235	COG3300	MHYT domain
HUO05_RS21240	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HUO05_RS21250	COG4181	ATPase activity
HUO05_RS21255	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HUO05_RS21265	COG1984	allophanate hydrolase subunit 2
HUO05_RS21270	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HUO05_RS21275	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HUO05_RS21280	COG5002	protein histidine kinase activity
HUO05_RS21280	COG5001	Diguanylate cyclase
HUO05_RS21280	COG3447	MASE1 domain protein
HUO05_RS21295	COG0583	DNA-binding transcription factor activity
HUO05_RS21300	COG0045	succinate-CoA ligase (ADP-forming) activity
HUO05_RS21300	COG1042	CoA-binding domain protein
HUO05_RS21300	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HUO05_RS21310	COG1181	Belongs to the D-alanine--D-alanine ligase family
HUO05_RS21320	COG0023	Translation Initiation Factor
HUO05_RS21395	COG0583	DNA-binding transcription factor activity
HUO05_RS21410	COG3140	Belongs to the UPF0181 family
HUO05_RS21435	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HUO05_RS21440	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HUO05_RS21460	COG2203	Gaf domain
HUO05_RS21460	COG3706	GGDEF domain
HUO05_RS21460	COG4251	negative regulation of phosphorylation
HUO05_RS21460	COG5001	Diguanylate cyclase
HUO05_RS21470	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HUO05_RS21475	COG4149	molybdate abc transporter
HUO05_RS21480	COG0725	ABC transporter, periplasmic molybdate-binding protein
HUO05_RS21490	COG3111	PFAM Bacterial OB fold (BOF) protein
HUO05_RS21500	COG4067	protein conserved in archaea
HUO05_RS21500	COG0189	ligase activity
HUO05_RS21510	COG2207	Transcriptional regulator
HUO05_RS21515	COG0534	Mate efflux family protein
HUO05_RS21520	COG0602	queuosine metabolic process
HUO05_RS21525	COG1328	CTP reductase activity
HUO05_RS21555	COG1794	racemase activity, acting on amino acids and derivatives
HUO05_RS21560	COG0384	phenazine biosynthesis protein PhzF
HUO05_RS21575	COG0243	molybdopterin cofactor binding
HUO05_RS21580	COG0583	DNA-binding transcription factor activity
HUO05_RS21585	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HUO05_RS21595	COG2197	response regulator
HUO05_RS21600	COG3851	Histidine kinase
HUO05_RS21605	COG2271	Major facilitator Superfamily
HUO05_RS21630	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HUO05_RS21635	COG3118	belongs to the thioredoxin family
HUO05_RS21670	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HUO05_RS21690	COG2116	formate transmembrane transporter activity
HUO05_RS21700	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUO05_RS21705	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HUO05_RS21725	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUO05_RS21775	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HUO05_RS21790	COG0277	FAD linked oxidase domain protein
HUO05_RS21795	COG0583	DNA-binding transcription factor activity
HUO05_RS21810	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HUO05_RS21825	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HUO05_RS21835	COG1288	antiporter activity
HUO05_RS21845	COG3040	lipid binding
HUO05_RS21855	COG0419	ATPase involved in DNA repair
HUO05_RS21860	COG0420	3'-5' exonuclease activity
HUO05_RS21875	COG3501	Rhs element vgr protein
HUO05_RS21930	COG0631	protein serine/threonine phosphatase activity
HUO05_RS21965	COG2815	serine threonine protein kinase
HUO05_RS21965	COG0515	serine threonine protein kinase
HUO05_RS21985	COG0745	RESPONSE REGULATOR receiver
HUO05_RS22015	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUO05_RS22015	COG2146	nitrite reductase [NAD(P)H] activity
HUO05_RS22020	COG1116	anion transmembrane transporter activity
HUO05_RS22025	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUO05_RS22030	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HUO05_RS22030	COG1116	anion transmembrane transporter activity
HUO05_RS22035	COG3707	response regulator
HUO05_RS22055	COG0243	molybdopterin cofactor binding
HUO05_RS22065	COG0814	amino acid
HUO05_RS22070	COG3706	GGDEF domain
HUO05_RS22125	COG2847	Copper chaperone PCu(A)C
HUO05_RS22130	COG1028	Short-chain dehydrogenase reductase Sdr
HUO05_RS22135	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HUO05_RS22145	COG0800	Aldolase
HUO05_RS22150	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUO05_RS22155	COG1917	Cupin 2, conserved barrel domain protein
HUO05_RS22200	COG2186	Transcriptional regulator
HUO05_RS22205	COG2186	Transcriptional regulator
HUO05_RS22215	COG2176	DNA-directed DNA polymerase activity
HUO05_RS22220	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HUO05_RS22290	COG4160	amino acid transport
HUO05_RS22295	COG4215	(ABC) transporter
HUO05_RS22300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUO05_RS22305	COG1126	abc transporter atp-binding protein
HUO05_RS22335	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HUO05_RS22345	COG1012	belongs to the aldehyde dehydrogenase family
HUO05_RS22360	COG1902	pentaerythritol trinitrate reductase activity
HUO05_RS22360	COG0446	pyridine nucleotide-disulphide oxidoreductase
HUO05_RS22365	COG0109	protoheme IX farnesyltransferase activity
HUO05_RS22370	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HUO05_RS22375	COG1845	cytochrome c oxidase, subunit III
HUO05_RS22380	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HUO05_RS22385	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HUO05_RS22390	COG1028	Short-chain dehydrogenase reductase Sdr
HUO05_RS22400	COG1024	Enoyl-CoA hydratase
HUO05_RS22405	COG1024	Enoyl-CoA hydratase
HUO05_RS22420	COG0183	Belongs to the thiolase family
HUO05_RS22430	COG1960	acyl-CoA dehydrogenase activity
HUO05_RS22435	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HUO05_RS22440	COG1024	Enoyl-CoA hydratase
HUO05_RS22455	COG0247	lactate metabolic process
HUO05_RS22455	COG0277	FAD linked oxidase domain protein
HUO05_RS22520	COG2095	MarC family integral membrane protein
HUO05_RS22535	COG0523	cobalamin synthesis protein
HUO05_RS22540	COG0739	heme binding
HUO05_RS22545	COG2988	succinylglutamate desuccinylase activity
HUO05_RS22550	COG0523	cobalamin synthesis protein
HUO05_RS22560	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HUO05_RS22565	COG0735	belongs to the Fur family
HUO05_RS22580	COG0730	response to heat
HUO05_RS22595	COG1073	alpha beta
HUO05_RS22600	COG1073	alpha beta
HUO05_RS22610	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HUO05_RS22620	COG0513	Belongs to the DEAD box helicase family
HUO05_RS22625	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
HUO05_RS22660	COG1119	ATPase activity
HUO05_RS22665	COG2200	EAL domain
HUO05_RS22685	COG0513	Belongs to the DEAD box helicase family
HUO05_RS22690	COG0523	cobalamin synthesis protein
HUO05_RS22700	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HUO05_RS22710	COG1278	Cold shock
HUO05_RS22715	COG0133	tryptophan synthase activity
HUO05_RS22725	COG4628	conserved protein (DUF2132)
HUO05_RS22730	COG0513	Belongs to the DEAD box helicase family
HUO05_RS22750	COG3530	Putative quorum-sensing-regulated virulence factor
HUO05_RS22775	COG3186	Phenylalanine-4-hydroxylase
HUO05_RS22780	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HUO05_RS22785	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HUO05_RS22810	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HUO05_RS22815	COG1454	alcohol dehydrogenase
HUO05_RS22820	COG2133	pyrroloquinoline quinone binding
HUO05_RS22830	COG0783	Belongs to the Dps family
HUO05_RS22835	COG0840	transmembrane signaling receptor activity
HUO05_RS22860	COG0784	Response regulator, receiver
HUO05_RS22860	COG2205	protein histidine kinase activity
HUO05_RS22865	COG1538	Outer membrane efflux protein
HUO05_RS22875	COG1132	(ABC) transporter
HUO05_RS22890	COG2199	diguanylate cyclase activity
HUO05_RS22895	COG3036	rescue of stalled ribosome
HUO05_RS22900	COG1278	Cold shock
HUO05_RS22930	COG0545	Peptidyl-prolyl cis-trans isomerase
HUO05_RS22935	COG0109	protoheme IX farnesyltransferase activity
HUO05_RS22940	COG1612	heme a metabolic process
HUO05_RS22960	COG1845	cytochrome c oxidase, subunit III
HUO05_RS22965	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
HUO05_RS22970	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HUO05_RS22975	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HUO05_RS22980	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HUO05_RS22990	COG1280	lysine exporter protein (LysE YggA)
HUO05_RS23010	COG0179	Fumarylacetoacetate (FAA) hydrolase
HUO05_RS23025	COG0697	spore germination
HUO05_RS23040	COG2814	Major facilitator Superfamily
HUO05_RS23045	COG0583	DNA-binding transcription factor activity
HUO05_RS23050	COG5001	Diguanylate cyclase
HUO05_RS23055	COG0739	heme binding
HUO05_RS23090	COG0814	amino acid
HUO05_RS23115	COG4989	oxidoreductase activity
HUO05_RS23140	COG1733	regulation of RNA biosynthetic process
HUO05_RS23155	COG0798	PFAM Bile acid sodium symporter
HUO05_RS23165	COG1881	PFAM PEBP family protein
HUO05_RS23180	COG1131	(ABC) transporter
HUO05_RS23185	COG0842	Transport permease protein
HUO05_RS23200	COG3383	formate dehydrogenase (NAD+) activity
HUO05_RS23220	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HUO05_RS23245	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HUO05_RS23255	COG2067	long-chain fatty acid transport protein
HUO05_RS23265	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HUO05_RS23275	COG1505	serine-type exopeptidase activity
HUO05_RS23280	COG0488	(ABC) transporter
HUO05_RS23285	COG0589	response to stress
HUO05_RS23290	COG2249	NAD(P)H dehydrogenase (quinone) activity
HUO05_RS23310	COG0366	Alpha amylase catalytic
HUO05_RS23315	COG0789	Transcriptional regulator
HUO05_RS23320	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HUO05_RS23330	COG4934	collagen metabolic process
HUO05_RS23345	COG0583	DNA-binding transcription factor activity
HUO05_RS23365	COG2610	gluconate transmembrane transporter activity
HUO05_RS23370	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUO05_RS23375	COG3622	Belongs to the hyi family
HUO05_RS23380	COG0235	Class ii aldolase
HUO05_RS23385	COG3395	kinase activity
HUO05_RS23390	COG2084	Dehydrogenase
HUO05_RS23395	COG1349	DNA-binding transcription factor activity
HUO05_RS23405	COG0747	negative chemotaxis
HUO05_RS23410	COG4608	Belongs to the ABC transporter superfamily
HUO05_RS23415	COG0444	Belongs to the ABC transporter superfamily
HUO05_RS23420	COG0534	Mate efflux family protein
HUO05_RS23425	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HUO05_RS23430	COG0784	Response regulator, receiver
HUO05_RS23430	COG0835	chemotaxis
HUO05_RS23440	COG0748	coenzyme F420 binding
HUO05_RS23445	COG3721	Heme iron utilization protein
HUO05_RS23455	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HUO05_RS23460	COG0811	peptide transport
HUO05_RS23465	COG0848	biopolymer transport protein
HUO05_RS23475	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUO05_RS23480	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HUO05_RS23520	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HUO05_RS23530	COG3217	Mosc domain protein beta barrel domain protein
HUO05_RS23530	COG0633	Ferredoxin
HUO05_RS23530	COG3217	Mosc domain protein beta barrel domain protein
HUO05_RS23530	COG0633	Ferredoxin
HUO05_RS23535	COG0401	homolog of Blt101
HUO05_RS23540	COG0418	dihydroorotase activity
HUO05_RS23545	COG2354	Protein conserved in bacteria
HUO05_RS23575	COG3833	ABC-type maltose transport systems, permease component
HUO05_RS23580	COG1175	transmembrane transport
HUO05_RS23590	COG3842	ATPase activity
HUO05_RS23595	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HUO05_RS23655	COG1309	transcriptional regulator
HUO05_RS23660	COG2130	NADP-dependent
HUO05_RS23670	COG0753	catalase activity
HUO05_RS23675	COG2084	Dehydrogenase
HUO05_RS23715	COG3772	lysozyme
HUO05_RS23815	COG1674	ftsk spoiiie
HUO05_RS24030	COG0358	DNA primase activity
HUO05_RS24760	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HUO05_RS24765	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HUO05_RS24820	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HUO05_RS25215	COG0330	HflC and HflK could
HUO05_RS25220	COG0330	HflC and HflK could
HUO05_RS25260	COG5001	Diguanylate cyclase
HUO05_RS25260	COG4251	negative regulation of phosphorylation
HUO05_RS25260	COG3706	GGDEF domain
HUO05_RS25260	COG2203	Gaf domain
HUO05_RS25310	COG1462	curli production assembly transport component CsgG
HUO05_RS25425	COG1192	Involved in chromosome partitioning
HUO05_RS25485	COG0629	single-stranded DNA binding
HUO05_RS25545	COG0776	regulation of translation
HUO05_RS25655	COG3311	Transcriptional regulator
HUO05_RS25820	COG2200	EAL domain