locus-tag	class	description
K01M1_RS00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K01M1_RS00015	COG0592	DNA-directed DNA polymerase activity
K01M1_RS00025	COG0187	DNA topoisomerase II activity
K01M1_RS00045	COG0071	Belongs to the small heat shock protein (HSP20) family
K01M1_RS00050	COG3977	Valine--pyruvate aminotransferase
K01M1_RS00055	COG0366	Alpha amylase catalytic
K01M1_RS00070	COG2119	membrane
K01M1_RS00080	COG0425	Belongs to the sulfur carrier protein TusA family
K01M1_RS00095	COG0604	alcohol dehydrogenase
K01M1_RS00100	COG0183	Belongs to the thiolase family
K01M1_RS00110	COG1739	Uncharacterized protein family UPF0029
K01M1_RS00115	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K01M1_RS00155	COG0583	DNA-binding transcription factor activity
K01M1_RS00160	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K01M1_RS00165	COG2960	long-chain fatty acid transporting porin activity
K01M1_RS00170	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K01M1_RS00175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K01M1_RS00235	COG4166	transmembrane transport
K01M1_RS00240	COG0601	transmembrane transport
K01M1_RS00245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K01M1_RS00260	COG1609	Transcriptional regulator
K01M1_RS00265	COG0583	DNA-binding transcription factor activity
K01M1_RS00280	COG0129	dihydroxy-acid dehydratase activity
K01M1_RS00285	COG3265	gluconokinase activity
K01M1_RS00290	COG2610	gluconate transmembrane transporter activity
K01M1_RS00295	COG0800	Aldolase
K01M1_RS00300	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
K01M1_RS00305	COG0583	DNA-binding transcription factor activity
K01M1_RS00310	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K01M1_RS00315	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
K01M1_RS00325	COG1522	sequence-specific DNA binding
K01M1_RS00330	COG5002	protein histidine kinase activity
K01M1_RS00330	COG5001	Diguanylate cyclase
K01M1_RS00335	COG0742	ribosomal rna small subunit methyltransferase
K01M1_RS00350	COG0589	response to stress
K01M1_RS00355	COG1528	Iron-storage protein
K01M1_RS00365	COG2081	HI0933 family
K01M1_RS00395	COG1597	lipid kinase activity
K01M1_RS00425	COG0628	permease
K01M1_RS00440	COG1322	Protein conserved in bacteria
K01M1_RS00445	COG2226	methyltransferase
K01M1_RS00450	COG3165	ubiquinone biosynthetic process from chorismate
K01M1_RS00455	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K01M1_RS00465	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K01M1_RS00470	COG0805	protein transport
K01M1_RS00480	COG0084	hydrolase, TatD family'
K01M1_RS00495	COG0456	acetyltransferase
K01M1_RS00505	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K01M1_RS00505	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K01M1_RS00510	COG0218	Necessary for normal cell division and for the maintenance of normal septation
K01M1_RS00545	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K01M1_RS00555	COG2204	response regulator
K01M1_RS00560	COG3852	Histidine kinase
K01M1_RS00570	COG0174	glutamine synthetase
K01M1_RS00575	COG1217	gtp-binding protein TYPA
K01M1_RS00580	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K01M1_RS00590	COG1295	ribonuclease BN
K01M1_RS00595	COG1490	D-aminoacyl-tRNA deacylase activity
K01M1_RS00600	COG0456	acetyltransferase
K01M1_RS00610	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
K01M1_RS00615	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
K01M1_RS00620	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
K01M1_RS00625	COG3031	protein transport across the cell outer membrane
K01M1_RS00635	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K01M1_RS00640	COG1459	type II secretion system
K01M1_RS00645	COG2165	general secretion pathway protein
K01M1_RS00650	COG2165	general secretion pathway protein
K01M1_RS00655	COG2165	general secretion pathway protein
K01M1_RS00660	COG4795	General secretion pathway protein
K01M1_RS00665	COG3156	type II secretion system protein K
K01M1_RS00670	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
K01M1_RS00675	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
K01M1_RS00685	COG1218	3'(2'),5'-bisphosphate nucleotidase
K01M1_RS00690	COG0494	nUDIX hydrolase
K01M1_RS00700	COG1040	competence protein
K01M1_RS00715	COG2183	response to ionizing radiation
K01M1_RS00725	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K01M1_RS00745	COG2233	PERMEase
K01M1_RS00750	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K01M1_RS00755	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K01M1_RS00760	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K01M1_RS00765	COG1758	RNA polymerase activity
K01M1_RS00770	COG0194	GDP metabolic process
K01M1_RS00790	COG0848	biopolymer transport protein
K01M1_RS00795	COG0811	peptide transport
K01M1_RS00820	COG4174	ABC transporter (Permease)
K01M1_RS00825	COG4239	(ABC) transporter, permease
K01M1_RS00830	COG0747	negative chemotaxis
K01M1_RS00835	COG0444	Belongs to the ABC transporter superfamily
K01M1_RS00840	COG4608	Belongs to the ABC transporter superfamily
K01M1_RS00850	COG1561	YicC-like family, N-terminal region
K01M1_RS00860	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
K01M1_RS00865	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K01M1_RS00870	COG1560	Kdo2-lipid A biosynthetic process
K01M1_RS00875	COG1309	transcriptional regulator
K01M1_RS00880	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K01M1_RS00895	COG2003	Belongs to the UPF0758 family
K01M1_RS00920	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K01M1_RS00935	COG0463	Glycosyl transferase, family 2
K01M1_RS00940	COG0859	PFAM glycosyl transferase family 9
K01M1_RS00945	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K01M1_RS00950	COG3642	lipopolysaccharide core region biosynthetic process
K01M1_RS00960	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
K01M1_RS01000	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K01M1_RS01005	COG1519	Transferase
K01M1_RS01010	COG0859	PFAM glycosyl transferase family 9
K01M1_RS01020	COG1560	Kdo2-lipid A biosynthetic process
K01M1_RS01040	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K01M1_RS01090	COG0438	transferase activity, transferring glycosyl groups
K01M1_RS01100	COG0438	transferase activity, transferring glycosyl groups
K01M1_RS01100	COG0297	glycogen (starch) synthase activity
K01M1_RS01110	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K01M1_RS01115	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
K01M1_RS01120	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K01M1_RS01155	COG1215	transferase activity, transferring glycosyl groups
K01M1_RS01180	COG0149	triose-phosphate isomerase activity
K01M1_RS01210	COG1494	fructose-1,6-bisphosphatase
K01M1_RS01225	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K01M1_RS01230	COG1575	Belongs to the MenA family. Type 1 subfamily
K01M1_RS01260	COG2003	Belongs to the UPF0758 family
K01M1_RS01275	COG4565	transcriptional regulatory protein
K01M1_RS01285	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
K01M1_RS01290	COG0511	ligase activity, forming carbon-carbon bonds
K01M1_RS01290	COG5016	pyruvate
K01M1_RS01295	COG3630	sodium ion export across plasma membrane
K01M1_RS01305	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
K01M1_RS01315	COG2301	Belongs to the HpcH HpaI aldolase family
K01M1_RS01320	COG3051	citrate lyase alpha subunit
K01M1_RS01330	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
K01M1_RS01345	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K01M1_RS01350	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
K01M1_RS01360	COG1609	Transcriptional regulator
K01M1_RS01365	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K01M1_RS01375	COG0254	rRNA binding
K01M1_RS01385	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K01M1_RS01390	COG0088	Forms part of the polypeptide exit tunnel
K01M1_RS01400	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K01M1_RS01405	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K01M1_RS01410	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K01M1_RS01415	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K01M1_RS01425	COG0255	Belongs to the universal ribosomal protein uL29 family
K01M1_RS01430	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K01M1_RS01440	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K01M1_RS01445	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K01M1_RS01450	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K01M1_RS01455	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K01M1_RS01460	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K01M1_RS01475	COG1841	ribosomal large subunit assembly
K01M1_RS01480	COG0200	Binds to the 23S rRNA
K01M1_RS01485	COG0201	protein transport
K01M1_RS01490	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K01M1_RS01495	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K01M1_RS01500	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K01M1_RS01510	COG0202	RNA polymerase activity
K01M1_RS01515	COG0203	ribosomal protein L17
K01M1_RS01525	COG0545	Peptidyl-prolyl cis-trans isomerase
K01M1_RS01535	COG2153	protein acetylation
K01M1_RS01540	COG0513	Belongs to the DEAD box helicase family
K01M1_RS01555	COG1648	precorrin-2 dehydrogenase activity
K01M1_RS01555	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K01M1_RS01560	COG0175	sulfate reduction
K01M1_RS01565	COG2895	sulfate adenylyltransferase (ATP) activity
K01M1_RS01570	COG0471	metal ion transport
K01M1_RS01570	COG3273	potassium ion transport
K01M1_RS01575	COG0529	Catalyzes the synthesis of activated sulfate
K01M1_RS01595	COG4181	ATPase activity
K01M1_RS01610	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
K01M1_RS01620	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K01M1_RS01625	COG0729	surface antigen
K01M1_RS01630	COG2911	Protein conserved in bacteria
K01M1_RS01635	COG2105	PFAM AIG2 family protein
K01M1_RS01645	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
K01M1_RS01650	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
K01M1_RS01660	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K01M1_RS01665	COG0163	prenyltransferase activity
K01M1_RS01670	COG4143	(ABC) transporter
K01M1_RS01675	COG1178	ABC-type Fe3 transport system permease component
K01M1_RS01680	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
K01M1_RS01685	COG0583	DNA-binding transcription factor activity
K01M1_RS01690	COG1902	pentaerythritol trinitrate reductase activity
K01M1_RS01710	COG2358	TRAP transporter, solute receptor (TAXI family
K01M1_RS01735	COG0142	geranyltranstransferase activity
K01M1_RS01740	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K01M1_RS01750	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K01M1_RS01755	COG2966	Psort location CytoplasmicMembrane, score
K01M1_RS01765	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
K01M1_RS01770	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
K01M1_RS01775	COG2967	ApaG domain
K01M1_RS01780	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K01M1_RS01785	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
K01M1_RS01790	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K01M1_RS01795	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
K01M1_RS01800	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
K01M1_RS01820	COG0473	3-isopropylmalate dehydrogenase activity
K01M1_RS01825	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K01M1_RS01850	COG0583	DNA-binding transcription factor activity
K01M1_RS01855	COG1022	Amp-dependent synthetase and ligase
K01M1_RS01860	COG0028	Belongs to the TPP enzyme family
K01M1_RS01865	COG0440	acetolactate synthase activity
K01M1_RS01880	COG0469	pyruvate kinase activity
K01M1_RS01885	COG1349	DNA-binding transcription factor activity
K01M1_RS01890	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K01M1_RS01900	COG2376	Dihydroxyacetone kinase
K01M1_RS01905	COG1461	Dihydroxyacetone kinase
K01M1_RS01920	COG3722	fumarate hydratase activity
K01M1_RS01930	COG2213	PTS system mannitol-specific
K01M1_RS01930	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K01M1_RS01965	COG0358	DNA primase activity
K01M1_RS01970	COG1610	YqeY-like protein
K01M1_RS01975	COG0828	Belongs to the bacterial ribosomal protein bS21 family
K01M1_RS01980	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K01M1_RS01985	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K01M1_RS01990	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
K01M1_RS01995	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
K01M1_RS02000	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K01M1_RS02005	COG1968	undecaprenyl-diphosphatase activity
K01M1_RS02015	COG3267	Type II secretory pathway component ExeA
K01M1_RS02015	COG3409	Peptidoglycan-binding domain 1 protein
K01M1_RS02025	COG0405	Gamma-glutamyltransferase
K01M1_RS02030	COG4991	sh3 domain protein
K01M1_RS02035	COG0306	phosphate transporter
K01M1_RS02040	COG1392	Phosphate transport regulator
K01M1_RS02045	COG3025	triphosphatase activity
K01M1_RS02060	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
K01M1_RS02065	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
K01M1_RS02065	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
K01M1_RS02070	COG1538	Outer membrane efflux protein
K01M1_RS02075	COG0494	nUDIX hydrolase
K01M1_RS02080	COG3151	Protein conserved in bacteria
K01M1_RS02090	COG3150	esterase
K01M1_RS02100	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K01M1_RS02105	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K01M1_RS02115	COG3105	Protein conserved in bacteria
K01M1_RS02125	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
K01M1_RS02140	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K01M1_RS02145	COG0723	plastoquinol--plastocyanin reductase activity
K01M1_RS02150	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K01M1_RS02155	COG2857	Cytochrome c1
K01M1_RS02160	COG0625	glutathione transferase activity
K01M1_RS02165	COG2969	positive regulation of protein catabolic process
K01M1_RS02175	COG2823	Periplasmic or secreted lipoprotein
K01M1_RS02180	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
K01M1_RS02195	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
K01M1_RS02215	COG3116	cell division
K01M1_RS02220	COG0768	penicillin binding
K01M1_RS02225	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K01M1_RS02230	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K01M1_RS02235	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K01M1_RS02240	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K01M1_RS02245	COG0772	Belongs to the SEDS family
K01M1_RS02260	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K01M1_RS02265	COG0849	cell division
K01M1_RS02270	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K01M1_RS02275	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
K01M1_RS02285	COG0653	protein targeting
K01M1_RS02290	COG0494	nUDIX hydrolase
K01M1_RS02300	COG0505	Belongs to the CarA family
K01M1_RS02305	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K01M1_RS02320	COG0730	response to heat
K01M1_RS02325	COG0583	DNA-binding transcription factor activity
K01M1_RS02330	COG2860	membrane
K01M1_RS02345	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K01M1_RS02355	COG0493	'glutamate synthase
K01M1_RS02360	COG0070	glutamate synthase
K01M1_RS02360	COG0067	glutamate synthase
K01M1_RS02360	COG0069	glutamate synthase activity
K01M1_RS02370	COG0070	glutamate synthase
K01M1_RS02370	COG0069	glutamate synthase activity
K01M1_RS02370	COG0067	glutamate synthase
K01M1_RS02375	COG1242	4 iron, 4 sulfur cluster binding
K01M1_RS02380	COG3706	GGDEF domain
K01M1_RS02380	COG4251	negative regulation of phosphorylation
K01M1_RS02380	COG5001	Diguanylate cyclase
K01M1_RS02380	COG2203	Gaf domain
K01M1_RS02385	COG2198	Histidine kinase
K01M1_RS02385	COG0784	Response regulator, receiver
K01M1_RS02385	COG5002	protein histidine kinase activity
K01M1_RS02395	COG0745	RESPONSE REGULATOR receiver
K01M1_RS02410	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K01M1_RS02430	COG0083	homoserine kinase activity
K01M1_RS02435	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
K01M1_RS02445	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
K01M1_RS02450	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
K01M1_RS02460	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K01M1_RS02475	COG1115	amino acid carrier protein
K01M1_RS02480	COG3022	response to hydroperoxide
K01M1_RS02485	COG0513	Belongs to the DEAD box helicase family
K01M1_RS02490	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
K01M1_RS02500	COG0716	FMN binding
K01M1_RS02505	COG4974	Belongs to the 'phage' integrase family
K01M1_RS02510	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K01M1_RS02515	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K01M1_RS02530	COG2204	response regulator
K01M1_RS02540	COG0667	Aldo Keto reductase
K01M1_RS02565	COG0730	response to heat
K01M1_RS02570	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K01M1_RS02575	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
K01M1_RS02585	COG1283	sodium-dependent phosphate transmembrane transporter activity
K01M1_RS02590	COG0583	DNA-binding transcription factor activity
K01M1_RS02595	COG0640	Transcriptional regulator
K01M1_RS02600	COG0268	Binds directly to 16S ribosomal RNA
K01M1_RS02605	COG0728	peptidoglycan biosynthetic process
K01M1_RS02610	COG0196	riboflavin kinase activity
K01M1_RS02625	COG1047	Peptidyl-prolyl cis-trans
K01M1_RS02630	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K01M1_RS02640	COG3279	Response regulator of the LytR AlgR family
K01M1_RS02645	COG3275	phosphorelay sensor kinase activity
K01M1_RS02650	COG1966	Carbon starvation protein
K01M1_RS02670	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
K01M1_RS02675	COG1472	Belongs to the glycosyl hydrolase 3 family
K01M1_RS02680	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K01M1_RS02685	COG0287	Prephenate dehydrogenase
K01M1_RS02685	COG1605	Chorismate mutase
K01M1_RS02690	COG0739	heme binding
K01M1_RS02700	COG0488	(ABC) transporter
K01M1_RS02710	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
K01M1_RS02715	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
K01M1_RS02720	COG0077	Prephenate dehydratase
K01M1_RS02720	COG1605	Chorismate mutase
K01M1_RS02725	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K01M1_RS02735	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K01M1_RS02740	COG0564	pseudouridine synthase activity
K01M1_RS02750	COG0542	response to heat
K01M1_RS02815	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K01M1_RS02820	COG0826	peptidase U32
K01M1_RS02825	COG2974	May be involved in recombination
K01M1_RS02835	COG0745	RESPONSE REGULATOR receiver
K01M1_RS02840	COG5002	protein histidine kinase activity
K01M1_RS02850	COG0248	Ppx GppA phosphatase
K01M1_RS02855	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K01M1_RS02860	COG0573	inorganic phosphate transmembrane transporter activity
K01M1_RS02865	COG0581	inorganic phosphate transmembrane transporter activity
K01M1_RS02870	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K01M1_RS02875	COG0704	Plays a role in the regulation of phosphate uptake
K01M1_RS02885	COG3142	Participates in the control of copper homeostasis
K01M1_RS02890	COG0450	alkyl hydroperoxide reductase
K01M1_RS02895	COG0583	DNA-binding transcription factor activity
K01M1_RS02900	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
K01M1_RS02910	COG0517	IMP dehydrogenase activity
K01M1_RS02920	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K01M1_RS02930	COG1862	Preprotein translocase
K01M1_RS02935	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K01M1_RS02940	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K01M1_RS02955	COG0483	inositol monophosphate 1-phosphatase activity
K01M1_RS02960	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
K01M1_RS02970	COG1104	cysteine desulfurase activity
K01M1_RS02975	COG0822	iron-sulfur transferase activity
K01M1_RS02990	COG0443	Heat shock 70 kDa protein
K01M1_RS02995	COG0633	Ferredoxin
K01M1_RS03000	COG2975	iron-sulfur cluster assembly
K01M1_RS03010	COG0105	UTP biosynthetic process
K01M1_RS03025	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K01M1_RS03030	COG0124	histidyl-tRNA synthetase
K01M1_RS03035	COG2976	Protein conserved in bacteria
K01M1_RS03040	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K01M1_RS03045	COG1160	GTP binding
K01M1_RS03065	COG0516	GMP reductase activity
K01M1_RS03065	COG0517	IMP dehydrogenase activity
K01M1_RS03075	COG0582	viral genome integration into host DNA
K01M1_RS03145	COG1757	Na H antiporter
K01M1_RS03155	COG1584	GPR1 FUN34 yaaH family protein
K01M1_RS03160	COG1115	amino acid carrier protein
K01M1_RS03175	COG2873	o-acetylhomoserine
K01M1_RS03180	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K01M1_RS03200	COG3153	acetyltransferase
K01M1_RS03200	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K01M1_RS03205	COG0583	DNA-binding transcription factor activity
K01M1_RS03230	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K01M1_RS03235	COG2867	negative regulation of translational initiation
K01M1_RS03240	COG2914	Belongs to the UPF0125 (RnfH) family
K01M1_RS03245	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K01M1_RS03255	COG0497	DNA recombination
K01M1_RS03265	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K01M1_RS03270	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K01M1_RS03275	COG1301	dicarboxylic acid transport
K01M1_RS03285	COG0484	heat shock protein binding
K01M1_RS03320	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
K01M1_RS03335	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
K01M1_RS03340	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K01M1_RS03340	COG0047	phosphoribosylformylglycinamidine synthase activity
K01M1_RS03370	COG2195	Cleaves the N-terminal amino acid of tripeptides
K01M1_RS03375	COG2252	PERMEase
K01M1_RS03380	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
K01M1_RS03385	COG1073	alpha beta
K01M1_RS03395	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K01M1_RS03400	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K01M1_RS03405	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K01M1_RS03410	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K01M1_RS03410	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K01M1_RS03425	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
K01M1_RS03435	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
K01M1_RS03440	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
K01M1_RS03445	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K01M1_RS03450	COG0142	geranyltranstransferase activity
K01M1_RS03455	COG1722	exodeoxyribonuclease VII activity
K01M1_RS03460	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K01M1_RS03470	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K01M1_RS03470	COG0301	tRNA thio-modification
K01M1_RS03475	COG0583	DNA-binding transcription factor activity
K01M1_RS03485	COG2363	Small membrane protein
K01M1_RS03495	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K01M1_RS03500	COG1611	Belongs to the LOG family
K01M1_RS03515	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K01M1_RS03515	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K01M1_RS03525	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
K01M1_RS03530	COG1464	Belongs to the NlpA lipoprotein family
K01M1_RS03535	COG2011	ABC-type metal ion transport system permease component
K01M1_RS03540	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K01M1_RS03550	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
K01M1_RS03560	COG1263	PTS System
K01M1_RS03560	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K01M1_RS03565	COG0366	Alpha amylase catalytic
K01M1_RS03580	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K01M1_RS03585	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K01M1_RS03590	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K01M1_RS03595	COG0321	lipoyl(octanoyl) transferase activity
K01M1_RS03605	COG1686	Belongs to the peptidase S11 family
K01M1_RS03610	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
K01M1_RS03615	COG0772	Belongs to the SEDS family
K01M1_RS03620	COG0768	penicillin binding
K01M1_RS03625	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K01M1_RS03630	COG0799	negative regulation of ribosome biogenesis
K01M1_RS03635	COG1466	dna polymerase III delta subunit
K01M1_RS03640	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
K01M1_RS03645	COG0495	leucyl-tRNA aminoacylation
K01M1_RS03650	COG2888	peptidyl-tyrosine sulfation
K01M1_RS03655	COG0815	Transfers the fatty acyl group on membrane lipoproteins
K01M1_RS03660	COG4535	Mg2 and Co2 transporter CorC
K01M1_RS03665	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K01M1_RS03670	COG1702	phosphate starvation-inducible protein PhoH
K01M1_RS03675	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K01M1_RS03685	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K01M1_RS03795	COG0012	GTP binding
K01M1_RS03800	COG0193	aminoacyl-tRNA hydrolase activity
K01M1_RS03805	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K01M1_RS03810	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K01M1_RS03815	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
K01M1_RS03820	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
K01M1_RS03830	COG2890	protein-(glutamine-N5) methyltransferase activity
K01M1_RS03835	COG3094	Invasion gene expression up-regulator, SirB
K01M1_RS03840	COG2912	Transglutaminase-like superfamily
K01M1_RS03845	COG2877	3-deoxy-8-phosphooctulonate synthase activity
K01M1_RS03850	COG0737	Belongs to the 5'-nucleotidase family
K01M1_RS03855	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K01M1_RS03860	COG1187	pseudouridine synthase activity
K01M1_RS03865	COG2840	Smr protein MutS2
K01M1_RS03905	COG2608	mercury ion transmembrane transporter activity
K01M1_RS03905	COG2217	Heavy metal translocating P-type atpase
K01M1_RS03920	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
K01M1_RS03975	COG0784	Response regulator, receiver
K01M1_RS03975	COG0835	chemotaxis
K01M1_RS03980	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
K01M1_RS03985	COG1815	bacterial-type flagellum-dependent cell motility
K01M1_RS03990	COG1558	bacterial-type flagellum-dependent cell motility
K01M1_RS04000	COG1749	Flagellar hook protein flgE
K01M1_RS04005	COG4787	bacterial-type flagellum-dependent cell motility
K01M1_RS04015	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
K01M1_RS04020	COG1706	bacterial-type flagellum-dependent cell motility
K01M1_RS04025	COG3951	Flagellar rod assembly protein muramidase FlgJ
K01M1_RS04025	COG1705	Flagellar rod assembly protein muramidase FlgJ
K01M1_RS04035	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K01M1_RS04040	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K01M1_RS04050	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K01M1_RS04055	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K01M1_RS04060	COG2190	(PTS) system
K01M1_RS04065	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K01M1_RS04070	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K01M1_RS04080	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K01M1_RS04085	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
K01M1_RS04120	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K01M1_RS04125	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K01M1_RS04135	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K01M1_RS04140	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K01M1_RS04145	COG2190	(PTS) system
K01M1_RS04150	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K01M1_RS04155	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K01M1_RS04165	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K01M1_RS04170	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
K01M1_RS04175	COG3115	cell septum assembly
K01M1_RS04180	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K01M1_RS04200	COG0330	HflC and HflK could
K01M1_RS04205	COG2194	sulfuric ester hydrolase activity
K01M1_RS04220	COG1192	Involved in chromosome partitioning
K01M1_RS04225	COG1215	transferase activity, transferring glycosyl groups
K01M1_RS04235	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
K01M1_RS04240	COG0457	Tetratricopeptide repeat
K01M1_RS04240	COG3118	belongs to the thioredoxin family
K01M1_RS04245	COG3118	belongs to the thioredoxin family
K01M1_RS04255	COG0300	oxidoreductase activity
K01M1_RS04260	COG1090	epimerase
K01M1_RS04290	COG0622	Phosphoesterase
K01M1_RS04310	COG3710	Transcriptional regulator
K01M1_RS04315	COG0326	Molecular chaperone. Has ATPase activity
K01M1_RS04325	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
K01M1_RS04330	COG3104	oligopeptide transport
K01M1_RS04335	COG0250	Participates in transcription elongation, termination and antitermination
K01M1_RS04340	COG0367	asparagine synthase
K01M1_RS04345	COG4651	solute:proton antiporter activity
K01M1_RS04345	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K01M1_RS04350	COG1940	carbohydrate kinase activity
K01M1_RS04350	COG1846	Transcriptional regulator
K01M1_RS04355	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K01M1_RS04365	COG2190	(PTS) system
K01M1_RS04365	COG1263	PTS System
K01M1_RS04365	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K01M1_RS04370	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K01M1_RS04375	COG0735	belongs to the Fur family
K01M1_RS04385	COG0716	FMN binding
K01M1_RS04395	COG0596	Alpha beta hydrolase
K01M1_RS04400	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
K01M1_RS04405	COG0033	Phosphoglucomutase
K01M1_RS04415	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
K01M1_RS04430	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
K01M1_RS04435	COG1053	succinate dehydrogenase
K01M1_RS04440	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K01M1_RS04445	COG0567	Dehydrogenase, E1 component
K01M1_RS04450	COG0508	dehydrogenase complex catalyzes the overall conversion of
K01M1_RS04455	COG0045	succinate-CoA ligase (ADP-forming) activity
K01M1_RS04465	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K01M1_RS04470	COG1121	(ABC) transporter
K01M1_RS04475	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
K01M1_RS04480	COG4977	sequence-specific DNA binding
K01M1_RS04485	COG1918	ferrous iron import across plasma membrane
K01M1_RS04510	COG0018	arginyl-trna synthetase
K01M1_RS04520	COG3102	Protein conserved in bacteria
K01M1_RS04535	COG0788	formyltetrahydrofolate deformylase activity
K01M1_RS04540	COG1199	ATP-dependent helicase activity
K01M1_RS04545	COG1214	PFAM Peptidase M22, glycoprotease
K01M1_RS04555	COG3065	identical protein binding
K01M1_RS04560	COG2267	carboxylic ester hydrolase activity
K01M1_RS04565	COG0318	PFAM AMP-dependent synthetase and ligase
K01M1_RS04570	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
K01M1_RS04575	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
K01M1_RS04580	COG2894	cell division
K01M1_RS04585	COG0850	regulation of cytokinetic process
K01M1_RS04590	COG3100	YcgL domain-containing protein
K01M1_RS04595	COG2951	lytic endotransglycosylase activity
K01M1_RS04605	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K01M1_RS04610	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K01M1_RS04620	COG2226	methyltransferase
K01M1_RS04630	COG1028	Short-chain dehydrogenase reductase Sdr
K01M1_RS04640	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K01M1_RS04665	COG2986	histidine ammonia-lyase
K01M1_RS04670	COG1216	Glycosyl transferase, family 2
K01M1_RS04675	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K01M1_RS04690	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K01M1_RS04695	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K01M1_RS04730	COG0513	Belongs to the DEAD box helicase family
K01M1_RS04735	COG0569	domain protein
K01M1_RS04740	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K01M1_RS04755	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
K01M1_RS04760	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K01M1_RS04765	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K01M1_RS04770	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K01M1_RS04795	COG0544	peptidyl-prolyl cis-trans isomerase activity
K01M1_RS04805	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K01M1_RS04810	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K01M1_RS04815	COG0776	regulation of translation
K01M1_RS04820	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K01M1_RS04825	COG1555	photosystem II stabilization
K01M1_RS04840	COG0232	Belongs to the dGTPase family. Type 2 subfamily
K01M1_RS04845	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
K01M1_RS04850	COG0436	Aminotransferase
K01M1_RS04855	COG1169	isochorismate synthase
K01M1_RS04860	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
K01M1_RS04870	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
K01M1_RS04890	COG2855	membrane
K01M1_RS04895	COG0477	Major facilitator Superfamily
K01M1_RS04940	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K01M1_RS04945	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K01M1_RS04960	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K01M1_RS04965	COG1522	sequence-specific DNA binding
K01M1_RS04975	COG1946	Acyl-CoA thioesterase
K01M1_RS04980	COG3126	Type III secretion system lipoprotein chaperone (YscW)
K01M1_RS05005	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K01M1_RS05010	COG0516	GMP reductase activity
K01M1_RS05010	COG0517	IMP dehydrogenase activity
K01M1_RS05035	COG0537	adenosine 5'-monophosphoramidase activity
K01M1_RS05060	COG3150	esterase
K01M1_RS05065	COG1252	NADH dehydrogenase
K01M1_RS05080	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K01M1_RS05090	COG4591	ABC-type transport system involved in lipoprotein release permease component
K01M1_RS05095	COG1136	(ABC) transporter
K01M1_RS05100	COG4591	ABC-type transport system involved in lipoprotein release permease component
K01M1_RS05110	COG0658	competence protein
K01M1_RS05110	COG2333	competence protein COMEC
K01M1_RS05115	COG1132	(ABC) transporter
K01M1_RS05135	COG2719	SpoVR family
K01M1_RS05140	COG2718	Belongs to the UPF0229 family
K01M1_RS05145	COG2766	serine protein kinase
K01M1_RS05155	COG3013	Belongs to the UPF0304 family
K01M1_RS05165	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K01M1_RS05175	COG1882	Formate acetyltransferase
K01M1_RS05220	COG0708	Exodeoxyribonuclease III
K01M1_RS05230	COG3923	Primosomal replication protein n
K01M1_RS05235	COG0730	response to heat
K01M1_RS05240	COG1199	ATP-dependent helicase activity
K01M1_RS05250	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K01M1_RS05255	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
K01M1_RS05260	COG1187	pseudouridine synthase activity
K01M1_RS05270	COG1278	Cold shock
K01M1_RS05275	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
K01M1_RS05280	COG0542	response to heat
K01M1_RS05285	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K01M1_RS05290	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
K01M1_RS05295	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
K01M1_RS05315	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K01M1_RS05320	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K01M1_RS05325	COG0297	glycogen (starch) synthase activity
K01M1_RS05345	COG3070	regulator of competence-specific genes
K01M1_RS05350	COG1609	Transcriptional regulator
K01M1_RS05355	COG3381	protein complex oligomerization
K01M1_RS05360	COG0745	RESPONSE REGULATOR receiver
K01M1_RS05365	COG1434	Gram-negative-bacterium-type cell wall biogenesis
K01M1_RS05370	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K01M1_RS05375	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
K01M1_RS05380	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
K01M1_RS05385	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K01M1_RS05405	COG4067	protein conserved in archaea
K01M1_RS05405	COG0189	ligase activity
K01M1_RS05415	COG0500	methyltransferase
K01M1_RS05425	COG1801	Protein of unknown function DUF72
K01M1_RS05435	COG0217	transcriptional regulatory protein
K01M1_RS05440	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
K01M1_RS05445	COG0632	four-way junction helicase activity
K01M1_RS05450	COG2255	four-way junction helicase activity
K01M1_RS05455	COG1271	oxidase subunit
K01M1_RS05460	COG1294	oxidase, subunit
K01M1_RS05465	COG4890	Cyd operon protein YbgT
K01M1_RS05475	COG0824	Thioesterase
K01M1_RS05480	COG0811	peptide transport
K01M1_RS05495	COG0823	Involved in the tonB-independent uptake of proteins
K01M1_RS05500	COG2885	chlorophyll binding
K01M1_RS05505	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
K01M1_RS05510	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
K01M1_RS05520	COG3766	membrane
K01M1_RS05530	COG0754	glutathionylspermidine amidase activity
K01M1_RS05540	COG5002	protein histidine kinase activity
K01M1_RS05540	COG0784	Response regulator, receiver
K01M1_RS05555	COG1294	oxidase, subunit
K01M1_RS05560	COG1271	oxidase subunit
K01M1_RS05580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K01M1_RS05585	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K01M1_RS05610	COG3568	Endonuclease Exonuclease Phosphatase
K01M1_RS05635	COG0583	DNA-binding transcription factor activity
K01M1_RS05645	COG0686	Belongs to the AlaDH PNT family
K01M1_RS05655	COG1674	ftsk spoiiie
K01M1_RS05665	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K01M1_RS05685	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K01M1_RS05690	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K01M1_RS05710	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
K01M1_RS05730	COG0300	oxidoreductase activity
K01M1_RS05745	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K01M1_RS05755	COG2268	Band 7 protein
K01M1_RS05765	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K01M1_RS05770	COG2915	High frequency lysogenization protein hflD homolog
K01M1_RS05785	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K01M1_RS05795	COG1757	Na H antiporter
K01M1_RS05805	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K01M1_RS05815	COG0131	Imidazoleglycerol-phosphate dehydratase
K01M1_RS05815	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
K01M1_RS05820	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
K01M1_RS05825	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K01M1_RS05835	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K01M1_RS05835	COG0140	phosphoribosyl-ATP diphosphatase activity
K01M1_RS05840	COG3012	SEC-C Motif Domain Protein
K01M1_RS05845	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
K01M1_RS05850	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K01M1_RS05855	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K01M1_RS05860	COG0215	cysteine-tRNA ligase activity
K01M1_RS05865	COG1435	thymidine kinase activity
K01M1_RS05895	COG2116	formate transmembrane transporter activity
K01M1_RS05905	COG0390	transport system, permease component
K01M1_RS05910	COG4459	periplasmic nitrate reductase
K01M1_RS05915	COG3005	denitrification pathway
K01M1_RS05920	COG0243	molybdopterin cofactor binding
K01M1_RS05935	COG1227	inorganic diphosphatase activity
K01M1_RS05945	COG4172	Belongs to the ABC transporter superfamily
K01M1_RS05955	COG4171	peptide transport system, permease
K01M1_RS05970	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
K01M1_RS05975	COG1842	Phage shock protein A
K01M1_RS05985	COG1983	PspC domain protein
K01M1_RS06005	COG2818	Glycosylase
K01M1_RS06010	COG5380	lipid catabolic process
K01M1_RS06015	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
K01M1_RS06020	COG0626	cystathionine gamma-synthase activity
K01M1_RS06030	COG0733	neurotransmitter:sodium symporter activity
K01M1_RS06035	COG0564	pseudouridine synthase activity
K01M1_RS06045	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K01M1_RS06050	COG1151	hydroxylamine reductase activity
K01M1_RS06055	COG3604	Transcriptional regulator
K01M1_RS06070	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K01M1_RS06075	COG4136	ATPase activity
K01M1_RS06080	COG4135	transport system, permease component
K01M1_RS06085	COG4134	Bacterial extracellular solute-binding protein
K01M1_RS06095	COG3313	Fe-S protein
K01M1_RS06120	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
K01M1_RS06140	COG1061	Type III restriction enzyme res subunit
K01M1_RS06145	COG1187	pseudouridine synthase activity
K01M1_RS06155	COG2814	Major facilitator Superfamily
K01M1_RS06165	COG0702	epimerase
K01M1_RS06170	COG0534	Mate efflux family protein
K01M1_RS06190	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K01M1_RS06205	COG1960	acyl-CoA dehydrogenase activity
K01M1_RS06210	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K01M1_RS06215	COG3273	potassium ion transport
K01M1_RS06215	COG2985	domain, Protein
K01M1_RS06220	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K01M1_RS06230	COG1737	Transcriptional regulator
K01M1_RS06235	COG0076	glutamate decarboxylase activity
K01M1_RS06245	COG2431	L-lysine efflux transmembrane transporter activity
K01M1_RS06265	COG3070	regulator of competence-specific genes
K01M1_RS06280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K01M1_RS06280	COG4191	Histidine kinase
K01M1_RS06290	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
K01M1_RS06300	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
K01M1_RS06305	COG4988	ABC transporter
K01M1_RS06310	COG0492	ferredoxin-NADP+ reductase activity
K01M1_RS06335	COG0471	metal ion transport
K01M1_RS06340	COG2949	membrane
K01M1_RS06345	COG0281	malic enzyme
K01M1_RS06350	COG1643	Atp-dependent helicase
K01M1_RS06365	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K01M1_RS06400	COG0277	FAD linked oxidase domain protein
K01M1_RS06400	COG0247	lactate metabolic process
K01M1_RS06415	COG2986	histidine ammonia-lyase
K01M1_RS06420	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
K01M1_RS06425	COG0010	Belongs to the arginase family
K01M1_RS06430	COG1228	amidohydrolase
K01M1_RS06435	COG2188	Transcriptional regulator
K01M1_RS06450	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K01M1_RS06460	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K01M1_RS06470	COG0393	Putative heavy-metal-binding
K01M1_RS06505	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K01M1_RS06510	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K01M1_RS06510	COG0072	phenylalanine-tRNA ligase activity
K01M1_RS06520	COG0776	regulation of translation
K01M1_RS06530	COG0500	methyltransferase
K01M1_RS06535	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
K01M1_RS06540	COG0295	cytidine deaminase activity
K01M1_RS06545	COG1346	cytolysis
K01M1_RS06550	COG1380	Effector of murein hydrolase LrgA
K01M1_RS06555	COG2925	Exonuclease
K01M1_RS06610	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K01M1_RS06640	COG1484	DNA-dependent DNA replication
K01M1_RS06785	COG1823	symporter activity
K01M1_RS06790	COG0702	epimerase
K01M1_RS06795	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
K01M1_RS06800	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
K01M1_RS06820	COG2988	succinylglutamate desuccinylase activity
K01M1_RS06825	COG4139	cobalamin transport
K01M1_RS06830	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
K01M1_RS06850	COG0583	DNA-binding transcription factor activity
K01M1_RS06860	COG1451	nucleotide metabolic process
K01M1_RS06865	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
K01M1_RS06895	COG3938	Belongs to the proline racemase family
K01M1_RS06910	COG2423	ornithine cyclodeaminase activity
K01M1_RS06915	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K01M1_RS06920	COG3842	ATPase activity
K01M1_RS06925	COG1176	ABC-type spermidine putrescine transport system, permease component I
K01M1_RS06930	COG1177	transmembrane transport
K01M1_RS06940	COG3291	Pkd domain containing protein
K01M1_RS06960	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K01M1_RS06965	COG0601	transmembrane transport
K01M1_RS06975	COG2195	Cleaves the N-terminal amino acid of tripeptides
K01M1_RS06985	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
K01M1_RS06995	COG0625	glutathione transferase activity
K01M1_RS07045	COG3755	Protein conserved in bacteria
K01M1_RS07070	COG1742	UPF0060 membrane protein
K01M1_RS07085	COG1757	Na H antiporter
K01M1_RS07090	COG0174	glutamine synthetase
K01M1_RS07100	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
K01M1_RS07105	COG1396	sequence-specific DNA binding
K01M1_RS07105	COG1917	Cupin 2, conserved barrel domain protein
K01M1_RS07110	COG1012	belongs to the aldehyde dehydrogenase family
K01M1_RS07115	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K01M1_RS07125	COG2957	Belongs to the agmatine deiminase family
K01M1_RS07130	COG1012	belongs to the aldehyde dehydrogenase family
K01M1_RS07135	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K01M1_RS07140	COG2200	EAL domain
K01M1_RS07150	COG1846	Transcriptional regulator
K01M1_RS07155	COG2315	Protein conserved in bacteria
K01M1_RS07195	COG3063	Type IV pilus biogenesis stability protein PilW
K01M1_RS07200	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
K01M1_RS07215	COG1560	Kdo2-lipid A biosynthetic process
K01M1_RS07225	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K01M1_RS07350	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
K01M1_RS07355	COG1280	lysine exporter protein (LysE YggA)
K01M1_RS07365	COG1115	amino acid carrier protein
K01M1_RS07390	COG1368	sulfuric ester hydrolase activity
K01M1_RS07395	COG2113	Glycine betaine
K01M1_RS07400	COG4176	ABC-type proline glycine betaine transport system permease component
K01M1_RS07405	COG4175	Glycine betaine
K01M1_RS07420	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K01M1_RS07425	COG0456	acetyltransferase
K01M1_RS07430	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K01M1_RS07435	COG0662	Cupin 2, conserved barrel domain protein
K01M1_RS07440	COG0527	aspartate kinase activity
K01M1_RS07445	COG3119	arylsulfatase activity
K01M1_RS07460	COG0641	radical SAM
K01M1_RS07475	COG3119	arylsulfatase activity
K01M1_RS07500	COG1538	Outer membrane efflux protein
K01M1_RS07515	COG1349	DNA-binding transcription factor activity
K01M1_RS07520	COG0673	inositol 2-dehydrogenase activity
K01M1_RS07525	COG4702	Belongs to the UPF0303 family
K01M1_RS07550	COG0471	metal ion transport
K01M1_RS07565	COG5001	Diguanylate cyclase
K01M1_RS07565	COG3300	MHYT domain
K01M1_RS07580	COG1328	CTP reductase activity
K01M1_RS07585	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K01M1_RS07595	COG0861	Integral membrane protein TerC family
K01M1_RS07605	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
K01M1_RS07615	COG0814	amino acid
K01M1_RS07630	COG1120	ATPase activity
K01M1_RS07635	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K01M1_RS07645	COG4774	siderophore transport
K01M1_RS07655	COG1132	(ABC) transporter
K01M1_RS07660	COG1132	(ABC) transporter
K01M1_RS07675	COG0583	DNA-binding transcription factor activity
K01M1_RS07700	COG0443	Heat shock 70 kDa protein
K01M1_RS07705	COG0443	Heat shock 70 kDa protein
K01M1_RS07750	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
K01M1_RS07755	COG1643	Atp-dependent helicase
K01M1_RS07770	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K01M1_RS07780	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K01M1_RS07785	COG1215	transferase activity, transferring glycosyl groups
K01M1_RS07790	COG0438	transferase activity, transferring glycosyl groups
K01M1_RS07820	COG0438	transferase activity, transferring glycosyl groups
K01M1_RS07825	COG0438	transferase activity, transferring glycosyl groups
K01M1_RS07830	COG2204	response regulator
K01M1_RS07865	COG1793	dna ligase
K01M1_RS07875	COG0534	Mate efflux family protein
K01M1_RS07880	COG0307	riboflavin synthase, alpha
K01M1_RS07890	COG3001	Fructosamine kinase
K01M1_RS07900	COG3706	GGDEF domain
K01M1_RS07910	COG0791	NLP P60 protein
K01M1_RS07945	COG3148	PFAM DTW domain containing protein
K01M1_RS07950	COG1940	carbohydrate kinase activity
K01M1_RS07965	COG0746	molybdenum cofactor guanylyltransferase activity
K01M1_RS07970	COG3842	ATPase activity
K01M1_RS07985	COG2204	response regulator
K01M1_RS07990	COG4191	Histidine kinase
K01M1_RS08000	COG0488	(ABC) transporter
K01M1_RS08005	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K01M1_RS08025	COG3381	protein complex oligomerization
K01M1_RS08035	COG0243	molybdopterin cofactor binding
K01M1_RS08035	COG3383	formate dehydrogenase (NAD+) activity
K01M1_RS08040	COG0437	4 iron, 4 sulfur cluster binding
K01M1_RS08070	COG0004	ammonium transporteR
K01M1_RS08075	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K01M1_RS08080	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K01M1_RS08090	COG1177	transmembrane transport
K01M1_RS08100	COG3842	ATPase activity
K01M1_RS08125	COG0589	response to stress
K01M1_RS08130	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K01M1_RS08145	COG2217	Heavy metal translocating P-type atpase
K01M1_RS08155	COG2010	Cytochrome c
K01M1_RS08170	COG3278	Belongs to the heme-copper respiratory oxidase family
K01M1_RS08185	COG0784	Response regulator, receiver
K01M1_RS08185	COG2205	protein histidine kinase activity
K01M1_RS08205	COG3120	sequence-specific DNA binding
K01M1_RS08210	COG1067	ATP-dependent peptidase activity
K01M1_RS08215	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K01M1_RS08230	COG0488	(ABC) transporter
K01M1_RS08240	COG0116	Belongs to the methyltransferase superfamily
K01M1_RS08240	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K01M1_RS08250	COG0167	dihydroorotate dehydrogenase activity
K01M1_RS08255	COG2902	Dehydrogenase
K01M1_RS08265	COG0308	aminopeptidase N
K01M1_RS08280	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
K01M1_RS08285	COG1956	GAF domain-containing protein
K01M1_RS08290	COG1132	(ABC) transporter
K01M1_RS08295	COG2995	paraquat-inducible protein a
K01M1_RS08300	COG3008	intermembrane lipid transfer
K01M1_RS08325	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K01M1_RS08330	COG1666	GTP binding
K01M1_RS08345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K01M1_RS08350	COG4597	amino acid ABC transporter
K01M1_RS08355	COG0765	amino acid transport
K01M1_RS08360	COG1126	abc transporter atp-binding protein
K01M1_RS08365	COG0670	Belongs to the BI1 family
K01M1_RS08380	COG2920	part of a sulfur-relay system
K01M1_RS08385	COG1254	Belongs to the acylphosphatase family
K01M1_RS08390	COG0840	transmembrane signaling receptor activity
K01M1_RS08410	COG2885	chlorophyll binding
K01M1_RS08435	COG2203	Gaf domain
K01M1_RS08435	COG2199	diguanylate cyclase activity
K01M1_RS08440	COG1414	Transcriptional regulator
K01M1_RS08450	COG0656	L-ascorbic acid biosynthetic process
K01M1_RS08455	COG0583	DNA-binding transcription factor activity
K01M1_RS08465	COG0583	DNA-binding transcription factor activity
K01M1_RS08470	COG2814	Major facilitator Superfamily
K01M1_RS08490	COG1335	isochorismatase
K01M1_RS08495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K01M1_RS08510	COG1410	methionine synthase
K01M1_RS08510	COG0646	methionine synthase
K01M1_RS08515	COG1126	abc transporter atp-binding protein
K01M1_RS08520	COG0765	amino acid transport
K01M1_RS08525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K01M1_RS08540	COG0583	DNA-binding transcription factor activity
K01M1_RS08555	COG0583	DNA-binding transcription factor activity
K01M1_RS08565	COG0583	DNA-binding transcription factor activity
K01M1_RS08580	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
K01M1_RS08585	COG0602	queuosine metabolic process
K01M1_RS08590	COG0561	phosphatase activity
K01M1_RS08615	COG2828	Protein conserved in bacteria
K01M1_RS08625	COG0372	Belongs to the citrate synthase family
K01M1_RS08630	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
K01M1_RS08665	COG0730	response to heat
K01M1_RS08670	COG2358	TRAP transporter, solute receptor (TAXI family
K01M1_RS08685	COG0457	Tetratricopeptide repeat
K01M1_RS08755	COG4790	Type iii secretion
K01M1_RS08760	COG4794	Type iii secretion
K01M1_RS08765	COG4791	protein targeting
K01M1_RS08770	COG4792	protein secretion
K01M1_RS08775	COG2207	Transcriptional regulator
K01M1_RS08805	COG3177	Filamentation induced by cAMP protein fic
K01M1_RS08825	COG4669	(LipO)protein
K01M1_RS08895	COG1012	belongs to the aldehyde dehydrogenase family
K01M1_RS08900	COG3284	Transcriptional regulator
K01M1_RS08915	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
K01M1_RS08920	COG0363	glucosamine-6-phosphate deaminase activity
K01M1_RS08925	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K01M1_RS08930	COG2207	Transcriptional regulator
K01M1_RS08940	COG4565	transcriptional regulatory protein
K01M1_RS08945	COG3290	protein histidine kinase activity
K01M1_RS08960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K01M1_RS08975	COG0583	DNA-binding transcription factor activity
K01M1_RS08990	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
K01M1_RS09000	COG2985	domain, Protein
K01M1_RS09025	COG2272	Belongs to the type-B carboxylesterase lipase family
K01M1_RS09035	COG0729	surface antigen
K01M1_RS09045	COG1280	lysine exporter protein (LysE YggA)
K01M1_RS09050	COG1280	lysine exporter protein (LysE YggA)
K01M1_RS09055	COG5507	3-demethylubiquinone-9 3-methyltransferase
K01M1_RS09075	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K01M1_RS09085	COG0110	maltose O-acetyltransferase activity
K01M1_RS09135	COG2801	Transposase and inactivated derivatives
K01M1_RS09175	COG1683	Conserved Protein
K01M1_RS09260	COG2801	Transposase and inactivated derivatives
K01M1_RS09295	COG1403	HNH endonuclease
K01M1_RS09395	COG4974	Belongs to the 'phage' integrase family
K01M1_RS09405	COG3706	GGDEF domain
K01M1_RS09420	COG2985	domain, Protein
K01M1_RS09425	COG0076	glutamate decarboxylase activity
K01M1_RS09430	COG2963	transposase activity
K01M1_RS09435	COG0598	Magnesium transport protein CorA
K01M1_RS09445	COG0387	Pfam Sodium calcium exchanger
K01M1_RS09450	COG0387	Pfam Sodium calcium exchanger
K01M1_RS09465	COG1289	transmembrane transporter activity
K01M1_RS09480	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
K01M1_RS09490	COG2985	domain, Protein
K01M1_RS09495	COG0025	NhaP-type Na H and K H
K01M1_RS09525	COG3302	dmso reductase anchor subunit
K01M1_RS09530	COG0437	4 iron, 4 sulfur cluster binding
K01M1_RS09535	COG0243	molybdopterin cofactor binding
K01M1_RS09545	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K01M1_RS09545	COG2221	Nitrite and sulphite reductase 4Fe-4S
K01M1_RS09550	COG0784	Response regulator, receiver
K01M1_RS09550	COG2205	protein histidine kinase activity
K01M1_RS09620	COG3477	response to acidic pH
K01M1_RS09625	COG3287	FIST C domain
K01M1_RS09625	COG2199	diguanylate cyclase activity
K01M1_RS09625	COG2200	EAL domain
K01M1_RS09630	COG2197	response regulator
K01M1_RS09705	COG1472	Belongs to the glycosyl hydrolase 3 family
K01M1_RS09715	COG2205	protein histidine kinase activity
K01M1_RS09715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K01M1_RS09720	COG2197	response regulator
K01M1_RS09790	COG1335	isochorismatase
K01M1_RS09905	COG4628	conserved protein (DUF2132)
K01M1_RS09955	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K01M1_RS09965	COG3768	UPF0283 membrane protein
K01M1_RS09970	COG3106	COG3106 Predicted ATPase
K01M1_RS09990	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K01M1_RS09995	COG2205	protein histidine kinase activity
K01M1_RS09995	COG0784	Response regulator, receiver
K01M1_RS10005	COG0494	nUDIX hydrolase
K01M1_RS10010	COG0814	amino acid
K01M1_RS10015	COG1760	l-serine dehydratase
K01M1_RS10020	COG2200	EAL domain
K01M1_RS10030	COG0720	synthase
K01M1_RS10035	COG0840	transmembrane signaling receptor activity
K01M1_RS10040	COG0017	Asparaginyl-tRNA synthetase
K01M1_RS10050	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K01M1_RS10065	COG1448	Aminotransferase
K01M1_RS10085	COG0840	transmembrane signaling receptor activity
K01M1_RS10090	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K01M1_RS10120	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
K01M1_RS10135	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K01M1_RS10140	COG3108	Peptidase M15
K01M1_RS10145	COG2989	Protein conserved in bacteria
K01M1_RS10170	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K01M1_RS10180	COG4235	cytochrome complex assembly
K01M1_RS10180	COG3088	subunit of a heme lyase
K01M1_RS10190	COG1138	Cytochrome C-type biogenesis protein
K01M1_RS10195	COG3301	Polysulphide reductase, NrfD
K01M1_RS10200	COG0437	4 iron, 4 sulfur cluster binding
K01M1_RS10210	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
K01M1_RS10230	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K01M1_RS10235	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K01M1_RS10265	COG0019	diaminopimelate decarboxylase activity
K01M1_RS10305	COG0322	excinuclease ABC activity
K01M1_RS10310	COG2197	response regulator
K01M1_RS10315	COG0417	DNA replication proofreading
K01M1_RS10335	COG1187	pseudouridine synthase activity
K01M1_RS10345	COG0009	L-threonylcarbamoyladenylate synthase
K01M1_RS10350	COG0613	PHP domain protein
K01M1_RS10360	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K01M1_RS10365	COG0512	Glutamine amidotransferase of anthranilate synthase
K01M1_RS10375	COG0135	phosphoribosylanthranilate isomerase activity
K01M1_RS10375	COG0134	indole-3-glycerol-phosphate synthase activity
K01M1_RS10385	COG0159	tryptophan synthase activity
K01M1_RS10390	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K01M1_RS10395	COG0318	PFAM AMP-dependent synthetase and ligase
K01M1_RS10405	COG1301	dicarboxylic acid transport
K01M1_RS10425	COG2917	probably involved in intracellular septation
K01M1_RS10435	COG2350	Protein conserved in bacteria
K01M1_RS10445	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
K01M1_RS10450	COG0583	DNA-binding transcription factor activity
K01M1_RS10465	COG5001	Diguanylate cyclase
K01M1_RS10470	COG1032	radical SAM domain protein
K01M1_RS10490	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
K01M1_RS10495	COG0463	Glycosyl transferase, family 2
K01M1_RS10500	COG0745	RESPONSE REGULATOR receiver
K01M1_RS10505	COG3850	Histidine kinase
K01M1_RS10505	COG5002	protein histidine kinase activity
K01M1_RS10555	COG1136	(ABC) transporter
K01M1_RS10555	COG0577	efflux transmembrane transporter activity
K01M1_RS10560	COG1136	(ABC) transporter
K01M1_RS10560	COG0577	efflux transmembrane transporter activity
K01M1_RS10565	COG1136	(ABC) transporter
K01M1_RS10565	COG0577	efflux transmembrane transporter activity
K01M1_RS10575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K01M1_RS10600	COG3118	belongs to the thioredoxin family
K01M1_RS10605	COG4232	protein-disulfide reductase activity
K01M1_RS10640	COG2863	cytochrome
K01M1_RS10645	COG3258	Cytochrome c
K01M1_RS10650	COG2995	paraquat-inducible protein a
K01M1_RS10655	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K01M1_RS10655	COG3008	intermembrane lipid transfer
K01M1_RS10675	COG4166	transmembrane transport
K01M1_RS10685	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
K01M1_RS10690	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
K01M1_RS10700	COG0539	negative regulation of cytoplasmic translation
K01M1_RS10705	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K01M1_RS10710	COG0616	signal peptide processing
K01M1_RS10715	COG1028	Short-chain dehydrogenase reductase Sdr
K01M1_RS10730	COG0587	DNA-directed DNA polymerase activity
K01M1_RS10735	COG0784	Response regulator, receiver
K01M1_RS10735	COG0835	chemotaxis
K01M1_RS10740	COG1940	carbohydrate kinase activity
K01M1_RS10745	COG0469	pyruvate kinase activity
K01M1_RS10750	COG4667	esterase of the alpha-beta hydrolase superfamily
K01M1_RS10765	COG0733	neurotransmitter:sodium symporter activity
K01M1_RS10780	COG1263	PTS System
K01M1_RS10780	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K01M1_RS10785	COG0084	hydrolase, TatD family'
K01M1_RS10790	COG0470	DNA polymerase III
K01M1_RS10795	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K01M1_RS10800	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K01M1_RS10830	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K01M1_RS10835	COG0416	fatty acid biosynthetic process
K01M1_RS10845	COG1399	metal-binding, possibly nucleic acid-binding protein
K01M1_RS10850	COG0424	maF-like protein
K01M1_RS10855	COG0564	pseudouridine synthase activity
K01M1_RS10865	COG1530	ribonuclease E activity
K01M1_RS10875	COG0659	secondary active sulfate transmembrane transporter activity
K01M1_RS10880	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K01M1_RS10885	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
K01M1_RS10895	COG0572	uridine kinase
K01M1_RS10905	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K01M1_RS10905	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K01M1_RS10925	COG2186	Transcriptional regulator
K01M1_RS10930	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K01M1_RS10935	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
K01M1_RS10940	COG3318	Belongs to the UPF0149 family
K01M1_RS10940	COG3012	SEC-C Motif Domain Protein
K01M1_RS10945	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K01M1_RS10950	COG3706	GGDEF domain
K01M1_RS10955	COG0366	Alpha amylase catalytic
K01M1_RS10960	COG1122	ATPase activity
K01M1_RS10965	COG4120	Belongs to the binding-protein-dependent transport system permease family
K01M1_RS10975	COG3092	negative regulation of chromosome organization
K01M1_RS10980	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K01M1_RS10985	COG0857	belongs to the CobB CobQ family
K01M1_RS10985	COG0280	phosphate acetyltransferase
K01M1_RS10995	COG0435	Glutathione S-transferase
K01M1_RS11005	COG0444	Belongs to the ABC transporter superfamily
K01M1_RS11010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K01M1_RS11015	COG0601	transmembrane transport
K01M1_RS11025	COG0314	molybdopterin synthase activity
K01M1_RS11030	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
K01M1_RS11035	COG0315	cyclic pyranopterin monophosphate synthase activity
K01M1_RS11040	COG0521	Mo-molybdopterin cofactor biosynthetic process
K01M1_RS11045	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K01M1_RS11050	COG0391	Required for morphogenesis under gluconeogenic growth conditions
K01M1_RS11055	COG2198	Histidine kinase
K01M1_RS11060	COG2204	response regulator
K01M1_RS11065	COG0556	nucleotide-excision repair
K01M1_RS11075	COG1882	Formate acetyltransferase
K01M1_RS11080	COG4657	Part of a membrane complex involved in electron transport
K01M1_RS11085	COG2878	Part of a membrane complex involved in electron transport
K01M1_RS11090	COG4656	Part of a membrane complex involved in electron transport
K01M1_RS11095	COG4658	electron transport chain
K01M1_RS11100	COG4659	FMN binding
K01M1_RS11105	COG4660	Part of a membrane complex involved in electron transport
K01M1_RS11110	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K01M1_RS11115	COG0346	lactoylglutathione lyase activity
K01M1_RS11125	COG2885	chlorophyll binding
K01M1_RS11135	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K01M1_RS11140	COG2056	Na+-H+ antiporter family
K01M1_RS11160	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
K01M1_RS11185	COG1012	belongs to the aldehyde dehydrogenase family
K01M1_RS11185	COG1454	alcohol dehydrogenase
K01M1_RS11190	COG2095	MarC family integral membrane protein
K01M1_RS11195	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K01M1_RS11200	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K01M1_RS11205	COG1757	Na H antiporter
K01M1_RS11220	COG3081	Nucleoid-associated protein
K01M1_RS11225	COG3082	Protein of unknown function (DUF1414)
K01M1_RS11240	COG0123	including yeast histone deacetylase and acetoin utilization protein
K01M1_RS11255	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K01M1_RS11260	COG0778	Nitroreductase
K01M1_RS11270	COG0446	pyridine nucleotide-disulphide oxidoreductase
K01M1_RS11270	COG1902	pentaerythritol trinitrate reductase activity
K01M1_RS11275	COG0616	signal peptide processing
K01M1_RS11280	COG0252	asparaginase activity
K01M1_RS11285	COG3139	Protein of unknown function (DUF1315)
K01M1_RS11295	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K01M1_RS11300	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K01M1_RS11315	COG2226	methyltransferase
K01M1_RS11335	COG1785	Belongs to the alkaline phosphatase family
K01M1_RS11345	COG0346	lactoylglutathione lyase activity
K01M1_RS11350	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
K01M1_RS11355	COG0668	transmembrane transport
K01M1_RS11360	COG2983	Belongs to the UPF0260 family
K01M1_RS11365	COG2261	transglycosylase associated protein
K01M1_RS11375	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K01M1_RS11380	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K01M1_RS11395	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K01M1_RS11400	COG2832	Protein of unknown function (DUF454)
K01M1_RS11410	COG0745	RESPONSE REGULATOR receiver
K01M1_RS11415	COG0583	DNA-binding transcription factor activity
K01M1_RS11420	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
K01M1_RS11425	COG1286	toxin biosynthetic process
K01M1_RS11430	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
K01M1_RS11435	COG0285	dihydrofolate synthase activity
K01M1_RS11440	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K01M1_RS11450	COG0101	tRNA pseudouridine synthase activity
K01M1_RS11460	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K01M1_RS11465	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K01M1_RS11475	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K01M1_RS11480	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K01M1_RS11480	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
K01M1_RS11485	COG0431	NADPH-dependent FMN reductase
K01M1_RS11500	COG3101	peptidyl-lysine hydroxylation
K01M1_RS11510	COG2860	membrane
K01M1_RS11515	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K01M1_RS11520	COG2890	protein-(glutamine-N5) methyltransferase activity
K01M1_RS11525	COG2840	Smr protein MutS2
K01M1_RS11530	COG2062	phosphohistidine phosphatase, SixA
K01M1_RS11545	COG1250	3-hydroxyacyl-CoA dehydrogenase
K01M1_RS11545	COG1024	Enoyl-CoA hydratase
K01M1_RS11550	COG0183	Belongs to the thiolase family
K01M1_RS11575	COG2067	long-chain fatty acid transport protein
K01M1_RS11585	COG4235	cytochrome complex assembly
K01M1_RS11585	COG3088	subunit of a heme lyase
K01M1_RS11595	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K01M1_RS11600	COG1138	Cytochrome C-type biogenesis protein
K01M1_RS11605	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
K01M1_RS11610	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K01M1_RS11615	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K01M1_RS11620	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K01M1_RS11625	COG4133	protoheme IX ABC transporter activity
K01M1_RS11635	COG0835	chemotaxis
K01M1_RS11645	COG1192	Involved in chromosome partitioning
K01M1_RS11650	COG2201	protein-glutamate methylesterase activity
K01M1_RS11655	COG0784	Response regulator, receiver
K01M1_RS11655	COG0643	Histidine kinase
K01M1_RS11655	COG2198	Histidine kinase
K01M1_RS11660	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
K01M1_RS11695	COG1684	flagellar biosynthetic protein fliR
K01M1_RS11700	COG1987	bacterial-type flagellum assembly
K01M1_RS11755	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K01M1_RS11765	COG1677	Flagellar hook-basal body complex protein FliE
K01M1_RS11785	COG1516	flagellar protein fliS
K01M1_RS11795	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
K01M1_RS11800	COG1334	flagellar protein FlaG
K01M1_RS11805	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K01M1_RS11810	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K01M1_RS11820	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K01M1_RS11825	COG2837	iron assimilation
K01M1_RS11850	COG1393	Belongs to the ArsC family
K01M1_RS11855	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K01M1_RS11870	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
K01M1_RS11875	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K01M1_RS11910	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K01M1_RS11990	COG0210	DNA helicase
K01M1_RS12005	COG0784	Response regulator, receiver
K01M1_RS12005	COG2205	protein histidine kinase activity
K01M1_RS12015	COG1278	Cold shock
K01M1_RS12035	COG1278	Cold shock
K01M1_RS12040	COG4974	Belongs to the 'phage' integrase family
K01M1_RS12045	COG0330	HflC and HflK could
K01M1_RS12065	COG1278	Cold shock
K01M1_RS12085	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K01M1_RS12100	COG4783	chaperone-mediated protein folding
K01M1_RS12105	COG1393	Belongs to the ArsC family
K01M1_RS12125	COG2233	PERMEase
K01M1_RS12130	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K01M1_RS12135	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K01M1_RS12140	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K01M1_RS12145	COG0121	glutamine amidotransferase
K01M1_RS12150	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
K01M1_RS12155	COG1960	acyl-CoA dehydrogenase activity
K01M1_RS12190	COG0328	RNA-DNA hybrid ribonuclease activity
K01M1_RS12195	COG2226	methyltransferase
K01M1_RS12200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K01M1_RS12205	COG1388	LysM domain
K01M1_RS12205	COG0741	lytic transglycosylase activity
K01M1_RS12215	COG3021	interspecies interaction between organisms
K01M1_RS12220	COG0347	Belongs to the P(II) protein family
K01M1_RS12235	COG0825	malonyl-CoA metabolic process
K01M1_RS12240	COG0587	DNA-directed DNA polymerase activity
K01M1_RS12250	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K01M1_RS12255	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K01M1_RS12265	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K01M1_RS12270	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
K01M1_RS12280	COG0750	zinc metalloprotease
K01M1_RS12285	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
K01M1_RS12290	COG0575	Belongs to the CDS family
K01M1_RS12295	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K01M1_RS12300	COG0233	cytoplasmic translational termination
K01M1_RS12305	COG0528	UMP kinase activity
K01M1_RS12310	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K01M1_RS12315	COG0052	Belongs to the universal ribosomal protein uS2 family
K01M1_RS12320	COG0024	Methionine aminopeptidase
K01M1_RS12325	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
K01M1_RS12335	COG0564	pseudouridine synthase activity
K01M1_RS12340	COG3098	single-species biofilm formation
K01M1_RS12375	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K01M1_RS12380	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K01M1_RS12405	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
K01M1_RS12415	COG0254	rRNA binding
K01M1_RS12420	COG1720	tRNA m6t6A37 methyltransferase activity
K01M1_RS12425	COG0442	prolyl-tRNA aminoacylation
K01M1_RS12445	COG0733	neurotransmitter:sodium symporter activity
K01M1_RS12460	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K01M1_RS12465	COG0514	ATP-dependent DNA helicase (RecQ)
K01M1_RS12495	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K01M1_RS12550	COG3621	Patatin-like phospholipase
K01M1_RS12585	COG0659	secondary active sulfate transmembrane transporter activity
K01M1_RS12590	COG0589	response to stress
K01M1_RS12595	COG0519	Catalyzes the synthesis of GMP from XMP
K01M1_RS12675	COG1477	protein flavinylation
K01M1_RS12680	COG2871	sodium ion transport
K01M1_RS12685	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K01M1_RS12690	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K01M1_RS12695	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K01M1_RS12700	COG1805	sodium ion transport
K01M1_RS12705	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K01M1_RS12710	COG0271	Belongs to the BolA IbaG family
K01M1_RS12715	COG2813	Specifically methylates the guanine in position
K01M1_RS12720	COG3056	Lipoprotein
K01M1_RS12740	COG1595	DNA-templated transcription, initiation
K01M1_RS12765	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K01M1_RS12770	COG0693	protein deglycase activity
K01M1_RS12775	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K01M1_RS12780	COG3706	GGDEF domain
K01M1_RS12785	COG2166	iron-sulfur cluster assembly
K01M1_RS12790	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
K01M1_RS12795	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
K01M1_RS12810	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K01M1_RS12810	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
K01M1_RS12820	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K01M1_RS12825	COG1074	ATP-dependent DNA helicase activity
K01M1_RS12835	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
K01M1_RS12870	COG0270	DNA (cytosine-5-)-methyltransferase activity
K01M1_RS12895	COG3141	response to X-ray
K01M1_RS12910	COG2171	N-acyltransferase activity
K01M1_RS12915	COG0584	glycerophosphoryl diester phosphodiesterase
K01M1_RS12920	COG2271	Major facilitator Superfamily
K01M1_RS12930	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K01M1_RS12935	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
K01M1_RS12940	COG1349	DNA-binding transcription factor activity
K01M1_RS12945	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
K01M1_RS12950	COG0598	Magnesium transport protein CorA
K01M1_RS12970	COG1609	Transcriptional regulator
K01M1_RS12975	COG0583	DNA-binding transcription factor activity
K01M1_RS13015	COG1022	Amp-dependent synthetase and ligase
K01M1_RS13025	COG0583	DNA-binding transcription factor activity
K01M1_RS13030	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K01M1_RS13035	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
K01M1_RS13045	COG0560	Phosphoserine phosphatase
K01M1_RS13055	COG0813	purine-nucleoside phosphorylase activity
K01M1_RS13060	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
K01M1_RS13065	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
K01M1_RS13070	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
K01M1_RS13075	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K01M1_RS13080	COG0084	hydrolase, TatD family'
K01M1_RS13110	COG3153	acetyltransferase
K01M1_RS13115	COG3154	lipid carrier protein
K01M1_RS13130	COG0826	peptidase U32
K01M1_RS13135	COG0826	peptidase U32
K01M1_RS13140	COG0534	Mate efflux family protein
K01M1_RS13155	COG1185	polyribonucleotide nucleotidyltransferase activity
K01M1_RS13160	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K01M1_RS13165	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K01M1_RS13170	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K01M1_RS13175	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K01M1_RS13180	COG0195	Participates in both transcription termination and antitermination
K01M1_RS13185	COG0779	Required for maturation of 30S ribosomal subunits
K01M1_RS13200	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K01M1_RS13210	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K01M1_RS13215	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
K01M1_RS13220	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K01M1_RS13225	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
K01M1_RS13230	COG1534	Rna-binding protein
K01M1_RS13235	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K01M1_RS13240	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K01M1_RS13245	COG2027	D-alanyl-D-alanine carboxypeptidase
K01M1_RS13255	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K01M1_RS13260	COG0739	heme binding
K01M1_RS13285	COG0628	permease
K01M1_RS13295	COG2205	protein histidine kinase activity
K01M1_RS13295	COG0784	Response regulator, receiver
K01M1_RS13300	COG0747	negative chemotaxis
K01M1_RS13310	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K01M1_RS13315	COG0444	Belongs to the ABC transporter superfamily
K01M1_RS13320	COG4608	Belongs to the ABC transporter superfamily
K01M1_RS13330	COG2971	BadF BadG BcrA BcrD
K01M1_RS13345	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K01M1_RS13350	COG3842	ATPase activity
K01M1_RS13360	COG1840	ABC-type Fe3 transport system, periplasmic component
K01M1_RS13365	COG0004	ammonium transporteR
K01M1_RS13375	COG3112	Uncharacterised protein family (UPF0231)
K01M1_RS13380	COG1049	propionate catabolic process, 2-methylcitrate cycle
K01M1_RS13385	COG1752	Esterase of the alpha-beta hydrolase superfamily
K01M1_RS13390	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K01M1_RS13395	COG1643	Atp-dependent helicase
K01M1_RS13400	COG1489	DNA binding
K01M1_RS13410	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K01M1_RS13420	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K01M1_RS13425	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
K01M1_RS13430	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
K01M1_RS13435	COG1560	Kdo2-lipid A biosynthetic process
K01M1_RS13445	COG0842	Transport permease protein
K01M1_RS13450	COG1131	(ABC) transporter
K01M1_RS13455	COG0659	secondary active sulfate transmembrane transporter activity
K01M1_RS13460	COG0288	reversible hydration of carbon dioxide
K01M1_RS13475	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K01M1_RS13480	COG0508	dehydrogenase complex catalyzes the overall conversion of
K01M1_RS13485	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
K01M1_RS13490	COG2186	Transcriptional regulator
K01M1_RS13500	COG0157	Belongs to the NadC ModD family
K01M1_RS13505	COG4969	Belongs to the N-Me-Phe pilin family
K01M1_RS13510	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K01M1_RS13515	COG1459	type II secretion system
K01M1_RS13525	COG0237	dephospho-CoA kinase activity
K01M1_RS13530	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
K01M1_RS13535	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
K01M1_RS13550	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K01M1_RS13555	COG0228	four-way junction DNA binding
K01M1_RS13560	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K01M1_RS13565	COG4137	Cytochrome C assembly protein
K01M1_RS13570	COG4536	flavin adenine dinucleotide binding
K01M1_RS13575	COG1854	S-ribosylhomocysteine lyase activity
K01M1_RS13590	COG0612	Peptidase, M16
K01M1_RS13595	COG1238	metal cluster binding
K01M1_RS13605	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
K01M1_RS13610	COG5016	pyruvate
K01M1_RS13610	COG0511	ligase activity, forming carbon-carbon bonds
K01M1_RS13615	COG3630	sodium ion export across plasma membrane
K01M1_RS13675	COG0527	aspartate kinase activity
K01M1_RS13680	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K01M1_RS13685	COG2137	regulation of response to DNA damage stimulus
K01M1_RS13695	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K01M1_RS13700	COG1546	Belongs to the CinA family
K01M1_RS13705	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K01M1_RS13710	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K01M1_RS13720	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K01M1_RS13725	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
K01M1_RS13735	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
K01M1_RS13740	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
K01M1_RS13745	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
K01M1_RS13750	COG0148	phosphopyruvate hydratase activity
K01M1_RS13755	COG0504	CTP synthase activity
K01M1_RS13760	COG3956	TIGRFAM MazG family protein
K01M1_RS13765	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K01M1_RS13775	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K01M1_RS13790	COG0736	holo-[acyl-carrier-protein] synthase activity
K01M1_RS13795	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
K01M1_RS13800	COG1381	Involved in DNA repair and RecF pathway recombination
K01M1_RS13805	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K01M1_RS13815	COG0681	Belongs to the peptidase S26 family
K01M1_RS13820	COG0481	GTPase activity
K01M1_RS13825	COG3086	response to oxidative stress
K01M1_RS13840	COG1595	DNA-templated transcription, initiation
K01M1_RS13850	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
K01M1_RS13860	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
K01M1_RS13880	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K01M1_RS13885	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K01M1_RS13890	COG3079	Belongs to the UPF0149 family
K01M1_RS13900	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
K01M1_RS13910	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K01M1_RS13915	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
K01M1_RS13920	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K01M1_RS13930	COG0583	DNA-binding transcription factor activity
K01M1_RS13945	COG0668	transmembrane transport
K01M1_RS13950	COG0191	fructose-bisphosphate aldolase activity
K01M1_RS13965	COG4771	TonB-dependent receptor
K01M1_RS13970	COG0583	DNA-binding transcription factor activity
K01M1_RS13975	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K01M1_RS13985	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K01M1_RS13995	COG3091	SprT-like family
K01M1_RS14000	COG2356	endonuclease I
K01M1_RS14005	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K01M1_RS14010	COG0189	ligase activity
K01M1_RS14015	COG1678	Uncharacterized ACR, COG1678
K01M1_RS14020	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K01M1_RS14035	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K01M1_RS14040	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K01M1_RS14045	COG0762	integral membrane protein
K01M1_RS14050	COG1872	DUF167
K01M1_RS14060	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
K01M1_RS14065	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K01M1_RS14070	COG2066	Belongs to the glutaminase family
K01M1_RS14080	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K01M1_RS14090	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
K01M1_RS14135	COG0840	transmembrane signaling receptor activity
K01M1_RS14215	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
K01M1_RS14220	COG1609	Transcriptional regulator
K01M1_RS14225	COG3394	polysaccharide catabolic process
K01M1_RS14230	COG1486	melibiose metabolic process
K01M1_RS14235	COG1447	Phosphotransferase system cellobiose-specific component IIA
K01M1_RS14240	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K01M1_RS14245	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K01M1_RS14250	COG0726	polysaccharide deacetylase
K01M1_RS14260	COG1028	Short-chain dehydrogenase reductase Sdr
K01M1_RS14275	COG0795	lipopolysaccharide-transporting ATPase activity
K01M1_RS14280	COG0795	lipopolysaccharide-transporting ATPase activity
K01M1_RS14285	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K01M1_RS14290	COG2927	DNA polymerase III (CHI subunit)
K01M1_RS14295	COG0525	valine-tRNA ligase activity
K01M1_RS14305	COG0456	acetyltransferase
K01M1_RS14335	COG0540	Belongs to the ATCase OTCase family
K01M1_RS14340	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
K01M1_RS14345	COG0251	oxidation-reduction process
K01M1_RS14350	COG0204	Acyl-transferase
K01M1_RS14355	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K01M1_RS14360	COG5007	Belongs to the BolA IbaG family
K01M1_RS14370	COG2854	intermembrane phospholipid transfer
K01M1_RS14375	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K01M1_RS14380	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K01M1_RS14385	COG1127	ABC transporter
K01M1_RS14395	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
K01M1_RS14395	COG0517	IMP dehydrogenase activity
K01M1_RS14405	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
K01M1_RS14410	COG1137	ATPase activity
K01M1_RS14420	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K01M1_RS14425	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K01M1_RS14430	COG1660	Displays ATPase and GTPase activities
K01M1_RS14435	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K01M1_RS14440	COG2239	Acts as a magnesium transporter
K01M1_RS14445	COG0312	modulator of DNA gyrase
K01M1_RS14450	COG3028	Belongs to the UPF0307 family
K01M1_RS14455	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K01M1_RS14460	COG0564	pseudouridine synthase activity
K01M1_RS14470	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K01M1_RS14475	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
K01M1_RS14480	COG0312	modulator of DNA gyrase
K01M1_RS14485	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K01M1_RS14490	COG3164	Protein of unknown function
K01M1_RS14500	COG0424	maF-like protein
K01M1_RS14505	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
K01M1_RS14510	COG1792	Involved in formation and maintenance of cell shape
K01M1_RS14515	COG1077	Cell shape determining protein MreB Mrl
K01M1_RS14550	COG2165	general secretion pathway protein
K01M1_RS14560	COG1459	type II secretion system
K01M1_RS14565	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K01M1_RS14575	COG3409	Peptidoglycan-binding domain 1 protein
K01M1_RS14575	COG3267	Type II secretory pathway component ExeA
K01M1_RS14580	COG1450	Type ii and iii secretion system protein
K01M1_RS14600	COG2200	EAL domain
K01M1_RS14600	COG2199	diguanylate cyclase activity
K01M1_RS14605	COG0629	single-stranded DNA binding
K01M1_RS14620	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K01M1_RS14635	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
K01M1_RS14645	COG0527	aspartate kinase activity
K01M1_RS14650	COG1410	methionine synthase
K01M1_RS14650	COG0646	methionine synthase
K01M1_RS14715	COG0175	sulfate reduction
K01M1_RS14720	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K01M1_RS14725	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K01M1_RS14745	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K01M1_RS14750	COG0735	belongs to the Fur family
K01M1_RS14760	COG0166	Belongs to the GPI family
K01M1_RS14765	COG0432	Pfam Uncharacterised protein family UPF0047
K01M1_RS14770	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K01M1_RS14795	COG2965	DNA replication, synthesis of RNA primer
K01M1_RS14800	COG0360	Binds together with S18 to 16S ribosomal RNA
K01M1_RS14805	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K01M1_RS14810	COG0338	D12 class N6 adenine-specific DNA methyltransferase
K01M1_RS14820	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K01M1_RS14825	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K01M1_RS14855	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
K01M1_RS14865	COG0678	peroxiredoxin activity
K01M1_RS14865	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K01M1_RS14870	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K01M1_RS14880	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
K01M1_RS14880	COG0165	Argininosuccinate lyase
K01M1_RS14885	COG0137	argininosuccinate synthase activity
K01M1_RS14895	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
K01M1_RS14905	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
K01M1_RS14915	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K01M1_RS14920	COG0527	aspartate kinase activity
K01M1_RS14920	COG0460	homoserine dehydrogenase
K01M1_RS14925	COG0626	cystathionine gamma-synthase activity
K01M1_RS14930	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
K01M1_RS14935	COG0281	malic enzyme
K01M1_RS14950	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K01M1_RS14955	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K01M1_RS14975	COG2923	Belongs to the DsrF TusC family
K01M1_RS14980	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
K01M1_RS14985	COG2964	Protein conserved in bacteria
K01M1_RS14990	COG0545	Peptidyl-prolyl cis-trans isomerase
K01M1_RS15005	COG1446	asparaginase
K01M1_RS15015	COG1047	Peptidyl-prolyl cis-trans
K01M1_RS15030	COG2249	NAD(P)H dehydrogenase (quinone) activity
K01M1_RS15035	COG0488	(ABC) transporter
K01M1_RS15045	COG0429	hydrolase of the alpha beta-hydrolase fold
K01M1_RS15055	COG3954	Phosphoribulokinase
K01M1_RS15060	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K01M1_RS15080	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K01M1_RS15085	COG0512	Glutamine amidotransferase of anthranilate synthase
K01M1_RS15100	COG0180	Tryptophanyl-tRNA synthetase
K01M1_RS15105	COG0546	phosphoglycolate phosphatase activity
K01M1_RS15110	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K01M1_RS15115	COG0557	exoribonuclease II activity
K01M1_RS15120	COG1959	2 iron, 2 sulfur cluster binding
K01M1_RS15125	COG1017	nitric oxide dioxygenase activity
K01M1_RS15125	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K01M1_RS15130	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
K01M1_RS15140	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K01M1_RS15145	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
K01M1_RS15150	COG0330	HflC and HflK could
K01M1_RS15155	COG0330	HflC and HflK could
K01M1_RS15160	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K01M1_RS15170	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K01M1_RS15175	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K01M1_RS15185	COG0802	atpase or kinase
K01M1_RS15195	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K01M1_RS15260	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
K01M1_RS15265	COG1162	GTPase activity
K01M1_RS15270	COG0688	phosphatidylethanolamine metabolic process
K01M1_RS15275	COG0471	metal ion transport
K01M1_RS15285	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
K01M1_RS15290	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K01M1_RS15295	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
K01M1_RS15300	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K01M1_RS15305	COG1045	serine acetyltransferase
K01M1_RS15310	COG4942	peptidase
K01M1_RS15330	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
K01M1_RS15335	COG1053	succinate dehydrogenase
K01M1_RS15340	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K01M1_RS15345	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
K01M1_RS15350	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
K01M1_RS15365	COG1509	lysine 2,3-aminomutase activity
K01M1_RS15370	COG1285	pathogenesis
K01M1_RS15380	COG0459	protein refolding
K01M1_RS15390	COG0534	Mate efflux family protein
K01M1_RS15395	COG0205	6-phosphofructokinase activity
K01M1_RS15405	COG3678	ATP-independent chaperone mediated protein folding
K01M1_RS15410	COG0745	RESPONSE REGULATOR receiver
K01M1_RS15415	COG2205	protein histidine kinase activity
K01M1_RS15425	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
K01M1_RS15430	COG3030	protein affecting phage T7 exclusion by the F plasmid
K01M1_RS15435	COG1027	Aspartate ammonia-lyase
K01M1_RS15440	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
K01M1_RS15445	COG4232	protein-disulfide reductase activity
K01M1_RS15455	COG3263	regulation of cellular component size
K01M1_RS15465	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K01M1_RS15490	COG2814	Major facilitator Superfamily
K01M1_RS15505	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K01M1_RS15510	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K01M1_RS15515	COG0511	ligase activity, forming carbon-carbon bonds
K01M1_RS15520	COG0439	Biotin carboxylase
K01M1_RS15525	COG2264	protein methyltransferase activity
K01M1_RS15530	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K01M1_RS15535	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
K01M1_RS15545	COG0488	(ABC) transporter
K01M1_RS15600	COG1982	Orn Lys Arg decarboxylase major
K01M1_RS15605	COG0531	amino acid
K01M1_RS15615	COG3710	Transcriptional regulator
K01M1_RS15620	COG0789	Transcriptional regulator
K01M1_RS15635	COG0151	Belongs to the GarS family
K01M1_RS15650	COG1253	flavin adenine dinucleotide binding
K01M1_RS15655	COG3068	Protein conserved in bacteria
K01M1_RS15665	COG1573	uracil-dna glycosylase
K01M1_RS15670	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K01M1_RS15675	COG2816	NAD+ diphosphatase activity
K01M1_RS15680	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
K01M1_RS15685	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K01M1_RS15690	COG0085	RNA polymerase activity
K01M1_RS15695	COG0222	ribosome binding
K01M1_RS15700	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K01M1_RS15715	COG0250	Participates in transcription elongation, termination and antitermination
K01M1_RS15720	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K01M1_RS15730	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K01M1_RS15765	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
K01M1_RS15765	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
K01M1_RS15770	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K01M1_RS15780	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K01M1_RS15855	COG4206	TonB-dependent receptor
K01M1_RS15875	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K01M1_RS15880	COG0534	Mate efflux family protein
K01M1_RS15885	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
K01M1_RS15895	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K01M1_RS15905	COG2937	Belongs to the GPAT DAPAT family
K01M1_RS15910	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
K01M1_RS15915	COG3161	chorismate lyase activity
K01M1_RS15920	COG1580	Controls the rotational direction of flagella during chemotaxis
K01M1_RS15925	COG0705	Rhomboid family
K01M1_RS15930	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K01M1_RS15945	COG2177	Part of the ABC transporter FtsEX involved in
K01M1_RS15950	COG2884	Cell division ATP-binding protein ftsE
K01M1_RS15955	COG0552	protein localization to endoplasmic reticulum
K01M1_RS15960	COG0742	ribosomal rna small subunit methyltransferase
K01M1_RS15970	COG2095	MarC family integral membrane protein
K01M1_RS16015	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K01M1_RS16020	COG0640	Transcriptional regulator
K01M1_RS16025	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
K01M1_RS16030	COG1280	lysine exporter protein (LysE YggA)
K01M1_RS16035	COG2267	carboxylic ester hydrolase activity
K01M1_RS16040	COG0561	phosphatase activity
K01M1_RS16055	COG3148	PFAM DTW domain containing protein
K01M1_RS16060	COG2200	EAL domain
K01M1_RS16060	COG3287	FIST C domain
K01M1_RS16060	COG2199	diguanylate cyclase activity
K01M1_RS16065	COG1011	Hydrolase
K01M1_RS16070	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
K01M1_RS16085	COG0019	diaminopimelate decarboxylase activity
K01M1_RS16095	COG1965	Belongs to the frataxin family
K01M1_RS16100	COG3072	Adenylate cyclase
K01M1_RS16105	COG0181	hydroxymethylbilane synthase activity
K01M1_RS16110	COG1587	Uroporphyrinogen-III synthase
K01M1_RS16115	COG2959	enzyme of heme biosynthesis
K01M1_RS16120	COG3071	HemY protein
K01M1_RS16165	COG0633	Ferredoxin
K01M1_RS16170	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
K01M1_RS16185	COG3118	belongs to the thioredoxin family
K01M1_RS16190	COG0513	Belongs to the DEAD box helicase family
K01M1_RS16195	COG0248	Ppx GppA phosphatase
K01M1_RS16205	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
K01M1_RS16215	COG0514	ATP-dependent DNA helicase (RecQ)
K01M1_RS16220	COG2962	Rard protein
K01M1_RS16230	COG1280	lysine exporter protein (LysE YggA)
K01M1_RS16235	COG0405	Gamma-glutamyltransferase
K01M1_RS16245	COG0210	DNA helicase
K01M1_RS16255	COG3220	belongs to the UPF0276 family
K01M1_RS16285	COG0006	proline dipeptidase activity
K01M1_RS16285	COG0006	proline dipeptidase activity
K01M1_RS16300	COG2104	thiamine diphosphate biosynthetic process
K01M1_RS16305	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K01M1_RS16325	COG2132	Multicopper oxidase
K01M1_RS16375	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
K01M1_RS16395	COG0009	L-threonylcarbamoyladenylate synthase
K01M1_RS16400	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
K01M1_RS16405	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K01M1_RS16410	COG0551	DNA topoisomerase type I activity
K01M1_RS16415	COG2922	Belongs to the Smg family
K01M1_RS16420	COG0758	DNA mediated transformation
K01M1_RS16430	COG0242	peptide deformylase activity
K01M1_RS16435	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K01M1_RS16440	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K01M1_RS16440	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K01M1_RS16445	COG0569	domain protein
K01M1_RS16450	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K01M1_RS16460	COG1272	protein, Hemolysin III
K01M1_RS16465	COG4326	sporulation control protein
K01M1_RS16475	COG3084	Protein conserved in bacteria
K01M1_RS16485	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
K01M1_RS16490	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K01M1_RS16495	COG0204	Acyl-transferase
K01M1_RS16505	COG0606	chelatase, subunit chli
K01M1_RS16515	COG3978	acetolactate synthase activity
K01M1_RS16520	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K01M1_RS16525	COG0129	dihydroxy-acid dehydratase activity
K01M1_RS16535	COG0583	DNA-binding transcription factor activity
K01M1_RS16540	COG2814	Major facilitator Superfamily
K01M1_RS16550	COG0765	amino acid transport
K01M1_RS16560	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K01M1_RS16565	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K01M1_RS16570	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K01M1_RS16575	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K01M1_RS16580	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K01M1_RS16585	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K01M1_RS16595	COG0356	it plays a direct role in the translocation of protons across the membrane
K01M1_RS16600	COG3312	ion transport
K01M1_RS16605	COG1475	DNA binding
K01M1_RS16610	COG1192	Involved in chromosome partitioning
K01M1_RS16615	COG0357	Ribosomal RNA small subunit methyltransferase G
K01M1_RS16620	COG0445	tRNA wobble uridine modification
K01M1_RS16625	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K01M1_RS16635	COG0706	membrane insertase activity
K01M1_RS16645	COG0594	ribonuclease P activity
K01M1_RS16655	COG1126	abc transporter atp-binding protein
K01M1_RS16680	COG1444	tRNA N-acetyltransferase activity
K01M1_RS16700	COG3340	Belongs to the peptidase S51 family
K01M1_RS16705	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K01M1_RS16710	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K01M1_RS16710	COG1263	PTS System
K01M1_RS16715	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
K01M1_RS16735	COG4166	transmembrane transport
K01M1_RS16780	COG0259	pyridoxamine-phosphate oxidase activity
K01M1_RS16805	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K01M1_RS16845	COG1132	(ABC) transporter
K01M1_RS16855	COG0513	Belongs to the DEAD box helicase family
K01M1_RS16860	COG2258	MOSC domain
K01M1_RS16925	COG3634	alkyl hydroperoxide reductase activity
K01M1_RS16970	COG1846	Transcriptional regulator
K01M1_RS16975	COG1764	response to oxidative stress
K01M1_RS17010	COG0577	efflux transmembrane transporter activity
K01M1_RS17015	COG1136	(ABC) transporter
K01M1_RS17030	COG0826	peptidase U32
K01M1_RS17060	COG1653	transport
K01M1_RS17065	COG0019	diaminopimelate decarboxylase activity
K01M1_RS17070	COG4264	IucA IucC family
K01M1_RS17095	COG4772	TonB-dependent receptor
K01M1_RS17100	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
K01M1_RS17105	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K01M1_RS17110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K01M1_RS17115	COG1120	ATPase activity
K01M1_RS17120	COG0840	transmembrane signaling receptor activity
K01M1_RS17125	COG0612	Peptidase, M16
K01M1_RS17135	COG0739	heme binding
K01M1_RS17150	COG2814	Major facilitator Superfamily
K01M1_RS17160	COG1609	Transcriptional regulator
K01M1_RS17165	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K01M1_RS17185	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K01M1_RS17185	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K01M1_RS17195	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K01M1_RS17200	COG1609	Transcriptional regulator
K01M1_RS17210	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K01M1_RS17225	COG0596	Alpha beta hydrolase
K01M1_RS17250	COG1760	l-serine dehydratase
K01M1_RS17260	COG4580	involved in the transport of maltose and maltodextrins
K01M1_RS17280	COG2356	endonuclease I
K01M1_RS17300	COG1982	Orn Lys Arg decarboxylase major
K01M1_RS17305	COG0531	amino acid
K01M1_RS17315	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
K01M1_RS17320	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
K01M1_RS17325	COG1162	GTPase activity
K01M1_RS17330	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K01M1_RS17330	COG1263	PTS System
K01M1_RS17335	COG1999	signal sequence binding
K01M1_RS17350	COG2909	trisaccharide binding
K01M1_RS17355	COG0058	SHG alpha-glucan phosphorylase activity
K01M1_RS17360	COG1640	4-alpha-glucanotransferase
K01M1_RS17365	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
K01M1_RS17370	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K01M1_RS17375	COG0366	Alpha amylase catalytic
K01M1_RS17390	COG3366	ferrous iron transmembrane transporter activity
K01M1_RS17395	COG0700	Nucleoside recognition
K01M1_RS17400	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K01M1_RS17405	COG3339	Conserved Protein
K01M1_RS17410	COG1301	dicarboxylic acid transport
K01M1_RS17420	COG0583	DNA-binding transcription factor activity
K01M1_RS17440	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K01M1_RS17485	COG3366	ferrous iron transmembrane transporter activity
K01M1_RS17490	COG0700	Nucleoside recognition
K01M1_RS17495	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K01M1_RS17500	COG3339	Conserved Protein
K01M1_RS17505	COG1301	dicarboxylic acid transport
K01M1_RS17515	COG0583	DNA-binding transcription factor activity
K01M1_RS17535	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K01M1_RS17540	COG1596	polysaccharide export
K01M1_RS17555	COG2095	MarC family integral membrane protein
K01M1_RS17560	COG4667	esterase of the alpha-beta hydrolase superfamily
K01M1_RS17565	COG3397	chitin binding
K01M1_RS17570	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
K01M1_RS17575	COG0415	Belongs to the DNA photolyase family
K01M1_RS17585	COG1054	Belongs to the UPF0176 family
K01M1_RS17595	COG1686	Belongs to the peptidase S11 family
K01M1_RS17620	COG0583	DNA-binding transcription factor activity
K01M1_RS17625	COG4628	conserved protein (DUF2132)
K01M1_RS17645	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
K01M1_RS17650	COG0628	permease
K01M1_RS17675	COG1289	transmembrane transporter activity
K01M1_RS17695	COG2814	Major facilitator Superfamily
K01M1_RS17705	COG0454	-acetyltransferase
K01M1_RS17715	COG0745	RESPONSE REGULATOR receiver
K01M1_RS17720	COG2205	protein histidine kinase activity
K01M1_RS17735	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K01M1_RS17740	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K01M1_RS17745	COG1882	Formate acetyltransferase
K01M1_RS17780	COG1360	Flagellar Motor Protein
K01M1_RS17785	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K01M1_RS17790	COG1191	sigma factor activity
K01M1_RS17795	COG1580	Controls the rotational direction of flagella during chemotaxis
K01M1_RS17810	COG1516	flagellar protein fliS
K01M1_RS17815	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
K01M1_RS17825	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K01M1_RS17840	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K01M1_RS17850	COG1987	bacterial-type flagellum assembly
K01M1_RS17890	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K01M1_RS17950	COG0346	lactoylglutathione lyase activity
K01M1_RS17975	COG0745	RESPONSE REGULATOR receiver
K01M1_RS18000	COG5001	Diguanylate cyclase
K01M1_RS18000	COG3300	MHYT domain
K01M1_RS18005	COG0156	8-amino-7-oxononanoate synthase activity
K01M1_RS18010	COG1063	alcohol dehydrogenase
K01M1_RS18045	COG0668	transmembrane transport
K01M1_RS18055	COG1304	FMN binding
K01M1_RS18060	COG1620	l-lactate permease
K01M1_RS18065	COG0583	DNA-binding transcription factor activity
K01M1_RS18070	COG1505	serine-type exopeptidase activity
K01M1_RS18075	COG4172	Belongs to the ABC transporter superfamily
K01M1_RS18085	COG1067	ATP-dependent peptidase activity
K01M1_RS18095	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K01M1_RS18115	COG1247	-acetyltransferase
K01M1_RS18120	COG0437	4 iron, 4 sulfur cluster binding
K01M1_RS18125	COG0348	domain, Protein
K01M1_RS18145	COG1122	ATPase activity
K01M1_RS18150	COG4720	Psort location CytoplasmicMembrane, score
K01M1_RS18155	COG1566	PFAM secretion protein HlyD family protein
K01M1_RS18180	COG0813	purine-nucleoside phosphorylase activity
K01M1_RS18185	COG3272	Protein of unknown function (DUF1722)
K01M1_RS18190	COG0789	Transcriptional regulator
K01M1_RS18195	COG0415	Belongs to the DNA photolyase family
K01M1_RS18200	COG1376	ErfK ybiS ycfS ynhG family protein
K01M1_RS18200	COG1388	LysM domain
K01M1_RS18210	COG0513	Belongs to the DEAD box helicase family
K01M1_RS18215	COG1770	oligopeptidase
K01M1_RS18220	COG4771	TonB-dependent receptor
K01M1_RS18250	COG0573	inorganic phosphate transmembrane transporter activity
K01M1_RS18255	COG0581	inorganic phosphate transmembrane transporter activity
K01M1_RS18260	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K01M1_RS18275	COG2304	oxidoreductase activity
K01M1_RS18295	COG0714	Associated with various cellular activities
K01M1_RS18310	COG2197	response regulator
K01M1_RS18345	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
K01M1_RS18350	COG1120	ATPase activity
K01M1_RS18355	COG4774	siderophore transport
K01M1_RS18360	COG1132	(ABC) transporter
K01M1_RS18365	COG2205	protein histidine kinase activity
K01M1_RS18375	COG0569	domain protein
K01M1_RS18380	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K01M1_RS18385	COG0583	DNA-binding transcription factor activity
K01M1_RS18400	COG1012	belongs to the aldehyde dehydrogenase family
K01M1_RS18405	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K01M1_RS18410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K01M1_RS18420	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
K01M1_RS18425	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K01M1_RS18455	COG2084	Dehydrogenase
K01M1_RS18460	COG0753	catalase activity
K01M1_RS18470	COG2130	NADP-dependent
K01M1_RS18475	COG1309	transcriptional regulator
K01M1_RS18480	COG3097	Belongs to the UPF0267 family
K01M1_RS18520	COG3206	protein involved in exopolysaccharide biosynthesis
K01M1_RS18520	COG0489	protein tyrosine kinase activity
K01M1_RS18535	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K01M1_RS18540	COG3842	ATPase activity
K01M1_RS18550	COG1175	transmembrane transport
K01M1_RS18555	COG3833	ABC-type maltose transport systems, permease component
K01M1_RS18585	COG2354	Protein conserved in bacteria
K01M1_RS18590	COG0418	dihydroorotase activity
K01M1_RS18600	COG0401	homolog of Blt101
K01M1_RS18605	COG3217	Mosc domain protein beta barrel domain protein
K01M1_RS18605	COG0633	Ferredoxin
K01M1_RS18605	COG3217	Mosc domain protein beta barrel domain protein
K01M1_RS18605	COG0633	Ferredoxin
K01M1_RS18615	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K01M1_RS18655	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
K01M1_RS18660	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K01M1_RS18670	COG0848	biopolymer transport protein
K01M1_RS18675	COG0811	peptide transport
K01M1_RS18680	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
K01M1_RS18690	COG3721	Heme iron utilization protein
K01M1_RS18695	COG0748	coenzyme F420 binding
K01M1_RS18705	COG0835	chemotaxis
K01M1_RS18705	COG0784	Response regulator, receiver
K01M1_RS18710	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K01M1_RS18715	COG0534	Mate efflux family protein
K01M1_RS18720	COG0444	Belongs to the ABC transporter superfamily
K01M1_RS18725	COG4608	Belongs to the ABC transporter superfamily
K01M1_RS18730	COG0747	negative chemotaxis
K01M1_RS18740	COG1349	DNA-binding transcription factor activity
K01M1_RS18745	COG2084	Dehydrogenase
K01M1_RS18750	COG3395	kinase activity
K01M1_RS18755	COG0235	Class ii aldolase
K01M1_RS18760	COG3622	Belongs to the hyi family
K01M1_RS18765	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K01M1_RS18770	COG2610	gluconate transmembrane transporter activity
K01M1_RS18790	COG0583	DNA-binding transcription factor activity
K01M1_RS18795	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K01M1_RS18805	COG4934	collagen metabolic process
K01M1_RS18815	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K01M1_RS18820	COG0789	Transcriptional regulator
K01M1_RS18825	COG0366	Alpha amylase catalytic
K01M1_RS18845	COG2249	NAD(P)H dehydrogenase (quinone) activity
K01M1_RS18850	COG0589	response to stress
K01M1_RS18855	COG0488	(ABC) transporter
K01M1_RS18860	COG1505	serine-type exopeptidase activity
K01M1_RS18870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K01M1_RS18880	COG2067	long-chain fatty acid transport protein
K01M1_RS18890	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K01M1_RS18915	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K01M1_RS18935	COG3383	formate dehydrogenase (NAD+) activity
K01M1_RS18945	COG0842	Transport permease protein
K01M1_RS18950	COG1131	(ABC) transporter
K01M1_RS18970	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
K01M1_RS18980	COG4145	pantothenate transmembrane transporter activity
K01M1_RS18985	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K01M1_RS18990	COG0800	Aldolase
K01M1_RS19000	COG2706	6-phosphogluconolactonase activity
K01M1_RS19005	COG0251	oxidation-reduction process
K01M1_RS19015	COG1881	PFAM PEBP family protein
K01M1_RS19025	COG0798	PFAM Bile acid sodium symporter
K01M1_RS19040	COG1733	regulation of RNA biosynthetic process
K01M1_RS19065	COG4989	oxidoreductase activity
K01M1_RS19090	COG0814	amino acid
K01M1_RS19105	COG3314	Sporulation integral membrane protein YlbJ
K01M1_RS19130	COG0739	heme binding
K01M1_RS19135	COG5001	Diguanylate cyclase
K01M1_RS19140	COG0583	DNA-binding transcription factor activity
K01M1_RS19145	COG2814	Major facilitator Superfamily
K01M1_RS19165	COG0697	spore germination
K01M1_RS19180	COG0179	Fumarylacetoacetate (FAA) hydrolase
K01M1_RS19200	COG1280	lysine exporter protein (LysE YggA)
K01M1_RS19210	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K01M1_RS19215	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K01M1_RS19220	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K01M1_RS19225	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
K01M1_RS19230	COG1845	cytochrome c oxidase, subunit III
K01M1_RS19250	COG1612	heme a metabolic process
K01M1_RS19255	COG0109	protoheme IX farnesyltransferase activity
K01M1_RS19260	COG0545	Peptidyl-prolyl cis-trans isomerase
K01M1_RS19290	COG1278	Cold shock
K01M1_RS19295	COG3036	rescue of stalled ribosome
K01M1_RS19300	COG2199	diguanylate cyclase activity
K01M1_RS19315	COG1132	(ABC) transporter
K01M1_RS19320	COG1132	(ABC) transporter
K01M1_RS19325	COG1538	Outer membrane efflux protein
K01M1_RS19330	COG2205	protein histidine kinase activity
K01M1_RS19330	COG0784	Response regulator, receiver
K01M1_RS19355	COG0840	transmembrane signaling receptor activity
K01M1_RS19360	COG0783	Belongs to the Dps family
K01M1_RS19370	COG2133	pyrroloquinoline quinone binding
K01M1_RS19375	COG1454	alcohol dehydrogenase
K01M1_RS19380	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
K01M1_RS19400	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K01M1_RS19405	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K01M1_RS19410	COG3186	Phenylalanine-4-hydroxylase
K01M1_RS19435	COG3530	Putative quorum-sensing-regulated virulence factor
K01M1_RS19455	COG0513	Belongs to the DEAD box helicase family
K01M1_RS19460	COG4628	conserved protein (DUF2132)
K01M1_RS19470	COG0133	tryptophan synthase activity
K01M1_RS19480	COG1278	Cold shock
K01M1_RS19490	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
K01M1_RS19500	COG0523	cobalamin synthesis protein
K01M1_RS19505	COG0513	Belongs to the DEAD box helicase family
K01M1_RS19525	COG2200	EAL domain
K01M1_RS19530	COG1119	ATPase activity
K01M1_RS19565	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
K01M1_RS19570	COG0513	Belongs to the DEAD box helicase family
K01M1_RS19585	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K01M1_RS19595	COG1073	alpha beta
K01M1_RS19600	COG1073	alpha beta
K01M1_RS19615	COG0730	response to heat
K01M1_RS19635	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K01M1_RS19645	COG0523	cobalamin synthesis protein
K01M1_RS19650	COG2988	succinylglutamate desuccinylase activity
K01M1_RS19655	COG0739	heme binding
K01M1_RS19665	COG0523	cobalamin synthesis protein
K01M1_RS19685	COG2095	MarC family integral membrane protein
K01M1_RS19710	COG1024	Enoyl-CoA hydratase
K01M1_RS19715	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K01M1_RS19720	COG1960	acyl-CoA dehydrogenase activity
K01M1_RS19730	COG0183	Belongs to the thiolase family
K01M1_RS19745	COG1024	Enoyl-CoA hydratase
K01M1_RS19750	COG1024	Enoyl-CoA hydratase
K01M1_RS19760	COG1028	Short-chain dehydrogenase reductase Sdr
K01M1_RS19765	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K01M1_RS19770	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K01M1_RS19775	COG1845	cytochrome c oxidase, subunit III
K01M1_RS19780	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
K01M1_RS19785	COG0109	protoheme IX farnesyltransferase activity
K01M1_RS19790	COG0446	pyridine nucleotide-disulphide oxidoreductase
K01M1_RS19790	COG1902	pentaerythritol trinitrate reductase activity
K01M1_RS19805	COG1012	belongs to the aldehyde dehydrogenase family
K01M1_RS19815	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K01M1_RS19845	COG1126	abc transporter atp-binding protein
K01M1_RS19850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K01M1_RS19855	COG4215	(ABC) transporter
K01M1_RS19860	COG4160	amino acid transport
K01M1_RS19925	COG0443	Heat shock 70 kDa protein
K01M1_RS19930	COG2847	Copper chaperone PCu(A)C
K01M1_RS19995	COG0814	amino acid
K01M1_RS20005	COG0243	molybdopterin cofactor binding
K01M1_RS20035	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K01M1_RS20035	COG1116	anion transmembrane transporter activity
K01M1_RS20040	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K01M1_RS20045	COG1116	anion transmembrane transporter activity
K01M1_RS20050	COG2146	nitrite reductase [NAD(P)H] activity
K01M1_RS20050	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K01M1_RS20100	COG2815	serine threonine protein kinase
K01M1_RS20100	COG0515	serine threonine protein kinase
K01M1_RS20135	COG0631	protein serine/threonine phosphatase activity
K01M1_RS20205	COG0420	3'-5' exonuclease activity
K01M1_RS20210	COG0419	ATPase involved in DNA repair
K01M1_RS20220	COG3040	lipid binding
K01M1_RS20230	COG1288	antiporter activity
K01M1_RS20240	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
K01M1_RS20255	COG2425	protein containing a von Willebrand factor type A (vWA) domain
K01M1_RS20270	COG0583	DNA-binding transcription factor activity
K01M1_RS20275	COG0277	FAD linked oxidase domain protein
K01M1_RS20290	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K01M1_RS20330	COG2176	DNA-directed DNA polymerase activity
K01M1_RS20375	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
K01M1_RS20380	COG1328	CTP reductase activity
K01M1_RS20585	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K01M1_RS20610	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K01M1_RS20615	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K01M1_RS20625	COG2116	formate transmembrane transporter activity
K01M1_RS20645	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
K01M1_RS20685	COG3118	belongs to the thioredoxin family
K01M1_RS20690	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K01M1_RS20715	COG2271	Major facilitator Superfamily
K01M1_RS20720	COG3851	Histidine kinase
K01M1_RS20725	COG2197	response regulator
K01M1_RS20735	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K01M1_RS20740	COG0583	DNA-binding transcription factor activity
K01M1_RS20750	COG0243	molybdopterin cofactor binding
K01M1_RS20765	COG0384	phenazine biosynthesis protein PhzF
K01M1_RS20770	COG1794	racemase activity, acting on amino acids and derivatives
K01M1_RS20800	COG1328	CTP reductase activity
K01M1_RS20805	COG0602	queuosine metabolic process
K01M1_RS20810	COG0534	Mate efflux family protein
K01M1_RS20815	COG2207	Transcriptional regulator
K01M1_RS20825	COG4067	protein conserved in archaea
K01M1_RS20825	COG0189	ligase activity
K01M1_RS20835	COG3111	PFAM Bacterial OB fold (BOF) protein
K01M1_RS20845	COG0725	ABC transporter, periplasmic molybdate-binding protein
K01M1_RS20850	COG4149	molybdate abc transporter
K01M1_RS20855	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
K01M1_RS20865	COG5001	Diguanylate cyclase
K01M1_RS20865	COG4251	negative regulation of phosphorylation
K01M1_RS20865	COG2203	Gaf domain
K01M1_RS20865	COG3706	GGDEF domain
K01M1_RS20885	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
K01M1_RS20890	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
K01M1_RS20915	COG3140	Belongs to the UPF0181 family
K01M1_RS20930	COG0583	DNA-binding transcription factor activity
K01M1_RS21085	COG0023	Translation Initiation Factor
K01M1_RS21095	COG1181	Belongs to the D-alanine--D-alanine ligase family
K01M1_RS21110	COG0045	succinate-CoA ligase (ADP-forming) activity
K01M1_RS21110	COG1042	CoA-binding domain protein
K01M1_RS21110	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K01M1_RS21115	COG0583	DNA-binding transcription factor activity
K01M1_RS21135	COG5001	Diguanylate cyclase
K01M1_RS21135	COG3447	MASE1 domain protein
K01M1_RS21135	COG5002	protein histidine kinase activity
K01M1_RS21140	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
K01M1_RS21145	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
K01M1_RS21150	COG1984	allophanate hydrolase subunit 2
K01M1_RS21160	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
K01M1_RS21165	COG4181	ATPase activity
K01M1_RS21175	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K01M1_RS21180	COG3300	MHYT domain
K01M1_RS21180	COG5001	Diguanylate cyclase
K01M1_RS21215	COG4533	DNA binding
K01M1_RS21225	COG2050	protein possibly involved in aromatic compounds catabolism
K01M1_RS21240	COG2067	long-chain fatty acid transport protein
K01M1_RS21245	COG2267	carboxylic ester hydrolase activity
K01M1_RS21265	COG0861	Integral membrane protein TerC family
K01M1_RS21270	COG0737	Belongs to the 5'-nucleotidase family
K01M1_RS21275	COG3593	DNA synthesis involved in DNA repair
K01M1_RS21285	COG0583	DNA-binding transcription factor activity
K01M1_RS21290	COG2116	formate transmembrane transporter activity
K01M1_RS21295	COG2353	YceI-like domain
K01M1_RS21300	COG3038	cytochrome b561
K01M1_RS21320	COG0513	Belongs to the DEAD box helicase family
K01M1_RS21325	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
K01M1_RS21335	COG0840	transmembrane signaling receptor activity
K01M1_RS21345	COG0546	phosphoglycolate phosphatase activity
K01M1_RS21360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K01M1_RS21365	COG2759	Belongs to the formate--tetrahydrofolate ligase family
K01M1_RS21370	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K01M1_RS21385	COG2207	Transcriptional regulator
K01M1_RS21390	COG1979	alcohol dehydrogenase
K01M1_RS21400	COG1126	abc transporter atp-binding protein
K01M1_RS21405	COG0765	amino acid transport
K01M1_RS21410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K01M1_RS21415	COG0765	amino acid transport
K01M1_RS21420	COG2200	EAL domain
K01M1_RS21420	COG2199	diguanylate cyclase activity
K01M1_RS21420	COG2203	Gaf domain
K01M1_RS21435	COG1609	Transcriptional regulator
K01M1_RS21440	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K01M1_RS21440	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K01M1_RS21445	COG1105	Belongs to the carbohydrate kinase PfkB family
K01M1_RS21450	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
K01M1_RS21450	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K01M1_RS21450	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K01M1_RS21480	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K01M1_RS21490	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K01M1_RS21495	COG0509	glycine decarboxylation via glycine cleavage system
K01M1_RS21505	COG0346	lactoylglutathione lyase activity
K01M1_RS21515	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K01M1_RS21520	COG0583	DNA-binding transcription factor activity
K01M1_RS21525	COG0697	spore germination
K01M1_RS21530	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K01M1_RS21560	COG2176	DNA-directed DNA polymerase activity
K01M1_RS21600	COG0242	peptide deformylase activity
K01M1_RS21635	COG2239	Acts as a magnesium transporter
K01M1_RS21655	COG0346	lactoylglutathione lyase activity
K01M1_RS21660	COG1902	pentaerythritol trinitrate reductase activity
K01M1_RS21670	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K01M1_RS21670	COG2755	lipolytic protein G-D-S-L family
K01M1_RS21680	COG5642	Protein of unknown function (DUF2384)
K01M1_RS21685	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
K01M1_RS21720	COG2076	Multidrug Resistance protein
K01M1_RS21740	COG2962	Rard protein
K01M1_RS21755	COG0784	Response regulator, receiver
K01M1_RS21755	COG0835	chemotaxis
K01M1_RS21765	COG2197	response regulator
K01M1_RS21775	COG3706	GGDEF domain
K01M1_RS21780	COG2197	response regulator
K01M1_RS21785	COG5001	Diguanylate cyclase
K01M1_RS21785	COG3300	MHYT domain
K01M1_RS21790	COG0784	Response regulator, receiver
K01M1_RS21790	COG2205	protein histidine kinase activity
K01M1_RS21795	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
K01M1_RS21815	COG0456	acetyltransferase
K01M1_RS21815	COG1214	PFAM Peptidase M22, glycoprotease
K01M1_RS21825	COG3069	C4-dicarboxylate transmembrane transporter activity
K01M1_RS21850	COG3111	PFAM Bacterial OB fold (BOF) protein
K01M1_RS21855	COG1597	lipid kinase activity
K01M1_RS21860	COG0583	DNA-binding transcription factor activity
K01M1_RS21865	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K01M1_RS21895	COG0714	Associated with various cellular activities
K01M1_RS21900	COG0641	radical SAM
K01M1_RS21905	COG3119	arylsulfatase activity
K01M1_RS21915	COG3119	arylsulfatase activity
K01M1_RS21920	COG0745	RESPONSE REGULATOR receiver
K01M1_RS21935	COG2205	protein histidine kinase activity
K01M1_RS21935	COG2198	Histidine kinase
K01M1_RS21935	COG0784	Response regulator, receiver
K01M1_RS21940	COG1879	ABC-type sugar transport system periplasmic component
K01M1_RS21945	COG1803	Methylglyoxal synthase
K01M1_RS21950	COG0210	DNA helicase
K01M1_RS21955	COG1289	transmembrane transporter activity
K01M1_RS21990	COG1629	transport
K01M1_RS21990	COG4771	TonB-dependent receptor
K01M1_RS22000	COG0789	Transcriptional regulator
K01M1_RS22005	COG4604	ABC transporter, ATP-binding protein
K01M1_RS22010	COG4605	iron ion homeostasis
K01M1_RS22015	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K01M1_RS22020	COG4607	ABC-type enterochelin transport system periplasmic component
K01M1_RS22030	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
K01M1_RS22045	COG1609	Transcriptional regulator
K01M1_RS22050	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K01M1_RS22055	COG1879	ABC-type sugar transport system periplasmic component
K01M1_RS22060	COG1172	Belongs to the binding-protein-dependent transport system permease family
K01M1_RS22065	COG1129	ABC transporter
K01M1_RS22070	COG1869	D-ribose catabolic process
K01M1_RS22075	COG5001	Diguanylate cyclase
K01M1_RS22130	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K01M1_RS22140	COG2205	protein histidine kinase activity
K01M1_RS22140	COG0784	Response regulator, receiver
K01M1_RS22155	COG0330	HflC and HflK could
K01M1_RS22170	COG0517	IMP dehydrogenase activity
K01M1_RS22170	COG4175	Glycine betaine
K01M1_RS22175	COG4176	ABC-type proline glycine betaine transport system permease component
K01M1_RS22190	COG1012	belongs to the aldehyde dehydrogenase family
K01M1_RS22195	COG1309	transcriptional regulator
K01M1_RS22205	COG1028	Short-chain dehydrogenase reductase Sdr
K01M1_RS22220	COG1024	Enoyl-CoA hydratase
K01M1_RS22225	COG1960	acyl-CoA dehydrogenase activity
K01M1_RS22235	COG0183	Belongs to the thiolase family
K01M1_RS22245	COG1960	acyl-CoA dehydrogenase activity
K01M1_RS22250	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K01M1_RS22260	COG4770	biotin carboxylase activity
K01M1_RS22275	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K01M1_RS22275	COG3264	Mechanosensitive ion channel
K01M1_RS22285	COG0110	maltose O-acetyltransferase activity
K01M1_RS22290	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K01M1_RS22295	COG1271	oxidase subunit
K01M1_RS22300	COG1294	oxidase, subunit
K01M1_RS22310	COG0384	phenazine biosynthesis protein PhzF
K01M1_RS22330	COG3527	Alpha-acetolactate decarboxylase
K01M1_RS22340	COG1028	Short-chain dehydrogenase reductase Sdr
K01M1_RS22345	COG0500	methyltransferase
K01M1_RS22375	COG1022	Amp-dependent synthetase and ligase
K01M1_RS22405	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K01M1_RS22410	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K01M1_RS22410	COG1263	PTS System
K01M1_RS22415	COG1486	melibiose metabolic process
K01M1_RS22420	COG2188	Transcriptional regulator
K01M1_RS22425	COG1320	monovalent cation:proton antiporter activity
K01M1_RS22430	COG2212	antiporter activity
K01M1_RS22435	COG1863	multisubunit Na H antiporter MnhE subunit
K01M1_RS22440	COG0651	ATP synthesis coupled electron transport
K01M1_RS22445	COG1006	Multisubunit Na H antiporter MnhC subunit
K01M1_RS22450	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K01M1_RS22450	COG2111	Na H antiporter
K01M1_RS22460	COG0589	response to stress
K01M1_RS22465	COG4221	oxidoreductase activity
K01M1_RS22470	COG0583	DNA-binding transcription factor activity
K01M1_RS22480	COG2814	Major facilitator Superfamily
K01M1_RS22545	COG1522	sequence-specific DNA binding
K01M1_RS22580	COG0515	serine threonine protein kinase
K01M1_RS22605	COG3501	Rhs element vgr protein
K01M1_RS22620	COG2204	response regulator
K01M1_RS22645	COG0739	heme binding
K01M1_RS22660	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K01M1_RS22710	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
K01M1_RS22720	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
K01M1_RS22720	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
K01M1_RS22735	COG4989	oxidoreductase activity
K01M1_RS22750	COG0038	chloride channel
K01M1_RS22785	COG2897	thiosulfate sulfurtransferase activity
K01M1_RS22805	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K01M1_RS22810	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K01M1_RS22815	COG0840	transmembrane signaling receptor activity
K01M1_RS22820	COG2814	Major facilitator Superfamily
K01M1_RS22825	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K01M1_RS22840	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K01M1_RS22850	COG0840	transmembrane signaling receptor activity
K01M1_RS22870	COG2195	Cleaves the N-terminal amino acid of tripeptides
K01M1_RS22885	COG2197	response regulator
K01M1_RS22890	COG3850	Histidine kinase
K01M1_RS22895	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K01M1_RS22905	COG0243	molybdopterin cofactor binding
K01M1_RS22915	COG3005	denitrification pathway
K01M1_RS22925	COG3243	poly(R)-hydroxyalkanoic acid synthase
K01M1_RS22935	COG0183	Belongs to the thiolase family
K01M1_RS22945	COG1280	lysine exporter protein (LysE YggA)
K01M1_RS22955	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K01M1_RS22960	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K01M1_RS23015	COG1846	Transcriptional regulator
K01M1_RS23020	COG2205	protein histidine kinase activity
K01M1_RS23020	COG0784	Response regulator, receiver
K01M1_RS23025	COG1879	ABC-type sugar transport system periplasmic component
K01M1_RS23035	COG2827	Endonuclease containing a URI domain
K01M1_RS23040	COG3132	Protein of unknown function, DUF480
K01M1_RS23060	COG0784	Response regulator, receiver
K01M1_RS23060	COG5002	protein histidine kinase activity
K01M1_RS23060	COG2205	protein histidine kinase activity
K01M1_RS23085	COG0583	DNA-binding transcription factor activity
K01M1_RS23100	COG0531	amino acid
K01M1_RS23115	COG2205	protein histidine kinase activity
K01M1_RS23120	COG0745	RESPONSE REGULATOR receiver
K01M1_RS23150	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K01M1_RS23155	COG2239	Acts as a magnesium transporter
K01M1_RS23160	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
K01M1_RS23165	COG0402	S-adenosylhomocysteine deaminase activity
K01M1_RS23170	COG1418	mRNA catabolic process
K01M1_RS23185	COG2814	Major facilitator Superfamily
K01M1_RS23195	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K01M1_RS23215	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K01M1_RS23230	COG0745	RESPONSE REGULATOR receiver
K01M1_RS23235	COG2205	protein histidine kinase activity
K01M1_RS23245	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K01M1_RS23250	COG2194	sulfuric ester hydrolase activity
K01M1_RS23270	COG4667	esterase of the alpha-beta hydrolase superfamily
K01M1_RS23275	COG1741	Belongs to the pirin family
K01M1_RS23280	COG1278	Cold shock
K01M1_RS23295	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K01M1_RS23300	COG0678	peroxiredoxin activity
K01M1_RS23300	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K01M1_RS23310	COG1686	Belongs to the peptidase S11 family
K01M1_RS23320	COG0625	glutathione transferase activity
K01M1_RS23330	COG1621	beta-fructofuranosidase activity
K01M1_RS23335	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K01M1_RS23340	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K01M1_RS23340	COG1263	PTS System
K01M1_RS23360	COG1028	Short-chain dehydrogenase reductase Sdr
K01M1_RS23375	COG3746	phosphate-selective porin O and P
K01M1_RS23390	COG0300	oxidoreductase activity
K01M1_RS23395	COG0583	DNA-binding transcription factor activity
K01M1_RS23400	COG2207	Transcriptional regulator
K01M1_RS23400	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K01M1_RS23405	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K01M1_RS23435	COG0513	Belongs to the DEAD box helicase family
K01M1_RS23445	COG0583	DNA-binding transcription factor activity
K01M1_RS23460	COG1902	pentaerythritol trinitrate reductase activity
K01M1_RS23465	COG1063	alcohol dehydrogenase
K01M1_RS23475	COG1028	Short-chain dehydrogenase reductase Sdr
K01M1_RS23485	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K01M1_RS23490	COG0006	proline dipeptidase activity
K01M1_RS23495	COG3608	succinylglutamate desuccinylase aspartoacylase
K01M1_RS23500	COG1522	sequence-specific DNA binding
K01M1_RS23505	COG1012	belongs to the aldehyde dehydrogenase family
K01M1_RS23510	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K01M1_RS23515	COG3122	Protein conserved in bacteria
K01M1_RS23530	COG0583	DNA-binding transcription factor activity
K01M1_RS23535	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K01M1_RS23540	COG0252	asparaginase activity
K01M1_RS23545	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
K01M1_RS23560	COG2197	response regulator
K01M1_RS23565	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K01M1_RS23590	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K01M1_RS23620	COG3842	ATPase activity
K01M1_RS23640	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K01M1_RS23670	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K01M1_RS23675	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K01M1_RS23710	COG0583	DNA-binding transcription factor activity
K01M1_RS23720	COG4948	Mandelate Racemase Muconate Lactonizing
K01M1_RS23755	COG1342	Belongs to the UPF0251 family
K01M1_RS23760	COG4176	ABC-type proline glycine betaine transport system permease component
K01M1_RS23765	COG4175	Glycine betaine
K01M1_RS23765	COG3448	diguanylate cyclase activity
K01M1_RS23770	COG3015	lipoprotein NlpE involved in copper resistance
K01M1_RS23775	COG3713	MltA-interacting MipA family protein
K01M1_RS23790	COG0583	DNA-binding transcription factor activity
K01M1_RS23815	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
K01M1_RS23825	COG1335	isochorismatase
K01M1_RS23840	COG1349	DNA-binding transcription factor activity
K01M1_RS23850	COG2070	2-Nitropropane dioxygenase
K01M1_RS23855	COG0531	amino acid
K01M1_RS23860	COG4302	ethanolamine ammonia-lyase activity
K01M1_RS23865	COG4303	Ethanolamine ammonia lyase large subunit
K01M1_RS23875	COG1309	transcriptional regulator
K01M1_RS23895	COG1280	lysine exporter protein (LysE YggA)
K01M1_RS23905	COG0459	protein refolding
K01M1_RS23910	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
K01M1_RS23920	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K01M1_RS23935	COG1304	FMN binding
K01M1_RS23960	COG1256	bacterial-type flagellum assembly
K01M1_RS23960	COG4786	Flagellar basal body rod
K01M1_RS23970	COG1706	bacterial-type flagellum-dependent cell motility
K01M1_RS23975	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
K01M1_RS23980	COG4786	Flagellar basal body rod
K01M1_RS23985	COG4787	bacterial-type flagellum-dependent cell motility
K01M1_RS24000	COG1558	bacterial-type flagellum-dependent cell motility
K01M1_RS24005	COG1815	bacterial-type flagellum-dependent cell motility
K01M1_RS24025	COG0741	lytic transglycosylase activity
K01M1_RS24030	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K01M1_RS24050	COG1760	l-serine dehydratase
K01M1_RS24065	COG0583	DNA-binding transcription factor activity
K01M1_RS24075	COG2866	Carboxypeptidase
K01M1_RS24080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K01M1_RS24090	COG2990	Protein conserved in bacteria
K01M1_RS24115	COG3842	ATPase activity
K01M1_RS24120	COG1840	ABC-type Fe3 transport system, periplasmic component
K01M1_RS24130	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K01M1_RS24140	COG1609	Transcriptional regulator
K01M1_RS24170	COG3240	lipase activity
K01M1_RS24175	COG1309	transcriptional regulator
K01M1_RS24190	COG0577	efflux transmembrane transporter activity
K01M1_RS24190	COG1136	(ABC) transporter
K01M1_RS24195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K01M1_RS24200	COG2067	long-chain fatty acid transport protein
K01M1_RS24210	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
K01M1_RS24225	COG1011	Hydrolase
K01M1_RS24265	COG0110	maltose O-acetyltransferase activity
K01M1_RS24270	COG1765	OsmC-like protein
K01M1_RS24275	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K01M1_RS24275	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K01M1_RS24290	COG3046	protein related to deoxyribodipyrimidine photolyase
K01M1_RS24295	COG0415	Belongs to the DNA photolyase family
K01M1_RS24300	COG3706	GGDEF domain
K01M1_RS24315	COG3706	GGDEF domain
K01M1_RS24330	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K01M1_RS24350	COG3033	Beta-eliminating lyase
K01M1_RS24360	COG1271	oxidase subunit
K01M1_RS24365	COG1294	oxidase, subunit
K01M1_RS24385	COG3179	chitinase
K01M1_RS24390	COG0579	oxidoreductase
K01M1_RS24415	COG3706	GGDEF domain
K01M1_RS24445	COG0583	DNA-binding transcription factor activity
K01M1_RS24470	COG0189	ligase activity
K01M1_RS24475	COG0189	ligase activity
K01M1_RS24475	COG4067	protein conserved in archaea
K01M1_RS24485	COG1166	arginine decarboxylase activity
K01M1_RS24490	COG0010	Belongs to the arginase family
K01M1_RS24495	COG2814	Major facilitator Superfamily
K01M1_RS24500	COG1770	oligopeptidase
K01M1_RS24515	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K01M1_RS24520	COG1121	(ABC) transporter
K01M1_RS24525	COG0803	Belongs to the bacterial solute-binding protein 9 family
K01M1_RS24565	COG0848	biopolymer transport protein
K01M1_RS24570	COG0811	peptide transport
K01M1_RS24575	COG0811	peptide transport
K01M1_RS24595	COG0745	RESPONSE REGULATOR receiver
K01M1_RS24600	COG0584	glycerophosphoryl diester phosphodiesterase
K01M1_RS24610	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K01M1_RS24675	COG0312	modulator of DNA gyrase
K01M1_RS24680	COG0312	modulator of DNA gyrase
K01M1_RS24685	COG0351	phosphomethylpyrimidine kinase
K01M1_RS24690	COG1116	anion transmembrane transporter activity
K01M1_RS24695	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K01M1_RS24700	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K01M1_RS24705	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
K01M1_RS24725	COG0243	molybdopterin cofactor binding
K01M1_RS24730	COG3005	denitrification pathway
K01M1_RS24735	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K01M1_RS24740	COG1028	Short-chain dehydrogenase reductase Sdr
K01M1_RS24755	COG0456	acetyltransferase
K01M1_RS24775	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K01M1_RS24780	COG1929	Belongs to the glycerate kinase type-1 family
K01M1_RS24785	COG2610	gluconate transmembrane transporter activity
K01M1_RS24790	COG3835	regulator
K01M1_RS24850	COG3047	cAMP biosynthetic process
K01M1_RS24855	COG1357	PFAM Pentapeptide repeats (8 copies)
K01M1_RS24885	COG2375	cellular response to nickel ion
K01M1_RS24890	COG0583	DNA-binding transcription factor activity
K01M1_RS24895	COG2162	N-hydroxyarylamine O-acetyltransferase activity
K01M1_RS24900	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
K01M1_RS24915	COG2199	diguanylate cyclase activity
K01M1_RS24925	COG0561	phosphatase activity
K01M1_RS24930	COG0583	DNA-binding transcription factor activity
K01M1_RS24945	COG0564	pseudouridine synthase activity
K01M1_RS24950	COG0534	Mate efflux family protein
K01M1_RS24965	COG3123	guanosine phosphorylase activity
K01M1_RS24980	COG0596	Alpha beta hydrolase
K01M1_RS25005	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K01M1_RS25015	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K01M1_RS25020	COG2169	Transcriptional regulator
K01M1_RS25020	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K01M1_RS25030	COG2259	Doxx family
K01M1_RS25035	COG1741	Belongs to the pirin family
K01M1_RS25055	COG0363	glucosamine-6-phosphate deaminase activity
K01M1_RS25065	COG0786	glutamate:sodium symporter activity
K01M1_RS25070	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K01M1_RS25075	COG1131	(ABC) transporter
K01M1_RS25085	COG0786	glutamate:sodium symporter activity
K01M1_RS25110	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K01M1_RS25120	COG3279	Response regulator of the LytR AlgR family
K01M1_RS25125	COG3275	phosphorelay sensor kinase activity
K01M1_RS25155	COG0772	Belongs to the SEDS family
K01M1_RS25180	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K01M1_RS25180	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
K01M1_RS25190	COG0444	Belongs to the ABC transporter superfamily
K01M1_RS25195	COG4608	Belongs to the ABC transporter superfamily