locus-tag	class	description
K04M1_RS00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K04M1_RS00015	COG0592	DNA-directed DNA polymerase activity
K04M1_RS00025	COG0187	DNA topoisomerase II activity
K04M1_RS00040	COG0071	Belongs to the small heat shock protein (HSP20) family
K04M1_RS00045	COG3977	Valine--pyruvate aminotransferase
K04M1_RS00050	COG0366	Alpha amylase catalytic
K04M1_RS00065	COG2119	membrane
K04M1_RS00075	COG0425	Belongs to the sulfur carrier protein TusA family
K04M1_RS00090	COG0604	alcohol dehydrogenase
K04M1_RS00095	COG0183	Belongs to the thiolase family
K04M1_RS00105	COG1739	Uncharacterized protein family UPF0029
K04M1_RS00110	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K04M1_RS00150	COG0583	DNA-binding transcription factor activity
K04M1_RS00155	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K04M1_RS00160	COG2960	long-chain fatty acid transporting porin activity
K04M1_RS00165	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K04M1_RS00170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K04M1_RS00230	COG4166	transmembrane transport
K04M1_RS00235	COG0601	transmembrane transport
K04M1_RS00240	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K04M1_RS00255	COG1609	Transcriptional regulator
K04M1_RS00260	COG0583	DNA-binding transcription factor activity
K04M1_RS00275	COG0129	dihydroxy-acid dehydratase activity
K04M1_RS00280	COG3265	gluconokinase activity
K04M1_RS00285	COG2610	gluconate transmembrane transporter activity
K04M1_RS00290	COG0800	Aldolase
K04M1_RS00295	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
K04M1_RS00300	COG0583	DNA-binding transcription factor activity
K04M1_RS00305	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K04M1_RS00310	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
K04M1_RS00320	COG1522	sequence-specific DNA binding
K04M1_RS00325	COG5002	protein histidine kinase activity
K04M1_RS00325	COG5001	Diguanylate cyclase
K04M1_RS00330	COG0742	ribosomal rna small subunit methyltransferase
K04M1_RS00345	COG0589	response to stress
K04M1_RS00350	COG1528	Iron-storage protein
K04M1_RS00360	COG2081	HI0933 family
K04M1_RS00390	COG1597	lipid kinase activity
K04M1_RS00420	COG0628	permease
K04M1_RS00435	COG1322	Protein conserved in bacteria
K04M1_RS00440	COG2226	methyltransferase
K04M1_RS00445	COG3165	ubiquinone biosynthetic process from chorismate
K04M1_RS00450	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K04M1_RS00460	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K04M1_RS00465	COG0805	protein transport
K04M1_RS00475	COG0084	hydrolase, TatD family'
K04M1_RS00490	COG0456	acetyltransferase
K04M1_RS00500	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K04M1_RS00500	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K04M1_RS00505	COG0218	Necessary for normal cell division and for the maintenance of normal septation
K04M1_RS00540	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K04M1_RS00550	COG2204	response regulator
K04M1_RS00555	COG3852	Histidine kinase
K04M1_RS00565	COG0174	glutamine synthetase
K04M1_RS00570	COG1217	gtp-binding protein TYPA
K04M1_RS00575	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K04M1_RS00585	COG1295	ribonuclease BN
K04M1_RS00590	COG1490	D-aminoacyl-tRNA deacylase activity
K04M1_RS00595	COG0456	acetyltransferase
K04M1_RS00605	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
K04M1_RS00610	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
K04M1_RS00615	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
K04M1_RS00620	COG3031	protein transport across the cell outer membrane
K04M1_RS00630	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K04M1_RS00635	COG1459	type II secretion system
K04M1_RS00640	COG2165	general secretion pathway protein
K04M1_RS00645	COG2165	general secretion pathway protein
K04M1_RS00650	COG2165	general secretion pathway protein
K04M1_RS00655	COG4795	General secretion pathway protein
K04M1_RS00660	COG3156	type II secretion system protein K
K04M1_RS00665	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
K04M1_RS00670	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
K04M1_RS00680	COG1218	3'(2'),5'-bisphosphate nucleotidase
K04M1_RS00685	COG0494	nUDIX hydrolase
K04M1_RS00695	COG1040	competence protein
K04M1_RS00710	COG2183	response to ionizing radiation
K04M1_RS00720	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K04M1_RS00740	COG2233	PERMEase
K04M1_RS00745	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K04M1_RS00750	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K04M1_RS00755	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K04M1_RS00760	COG1758	RNA polymerase activity
K04M1_RS00765	COG0194	GDP metabolic process
K04M1_RS00785	COG0848	biopolymer transport protein
K04M1_RS00790	COG0811	peptide transport
K04M1_RS00815	COG4174	ABC transporter (Permease)
K04M1_RS00820	COG4239	(ABC) transporter, permease
K04M1_RS00825	COG0747	negative chemotaxis
K04M1_RS00830	COG0444	Belongs to the ABC transporter superfamily
K04M1_RS00835	COG4608	Belongs to the ABC transporter superfamily
K04M1_RS00845	COG1561	YicC-like family, N-terminal region
K04M1_RS00855	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
K04M1_RS00860	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K04M1_RS00865	COG1560	Kdo2-lipid A biosynthetic process
K04M1_RS00870	COG1309	transcriptional regulator
K04M1_RS00875	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K04M1_RS00890	COG2003	Belongs to the UPF0758 family
K04M1_RS00915	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K04M1_RS00930	COG0463	Glycosyl transferase, family 2
K04M1_RS00935	COG0859	PFAM glycosyl transferase family 9
K04M1_RS00940	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K04M1_RS00945	COG3642	lipopolysaccharide core region biosynthetic process
K04M1_RS00955	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
K04M1_RS00995	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K04M1_RS01000	COG1519	Transferase
K04M1_RS01005	COG0859	PFAM glycosyl transferase family 9
K04M1_RS01015	COG1560	Kdo2-lipid A biosynthetic process
K04M1_RS01115	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K04M1_RS01120	COG1519	Transferase
K04M1_RS01125	COG0859	PFAM glycosyl transferase family 9
K04M1_RS01135	COG1560	Kdo2-lipid A biosynthetic process
K04M1_RS01155	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K04M1_RS01205	COG0438	transferase activity, transferring glycosyl groups
K04M1_RS01215	COG0297	glycogen (starch) synthase activity
K04M1_RS01215	COG0438	transferase activity, transferring glycosyl groups
K04M1_RS01225	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K04M1_RS01230	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
K04M1_RS01235	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K04M1_RS01270	COG1215	transferase activity, transferring glycosyl groups
K04M1_RS01295	COG0149	triose-phosphate isomerase activity
K04M1_RS01325	COG1494	fructose-1,6-bisphosphatase
K04M1_RS01340	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K04M1_RS01345	COG1575	Belongs to the MenA family. Type 1 subfamily
K04M1_RS01375	COG2003	Belongs to the UPF0758 family
K04M1_RS01390	COG4565	transcriptional regulatory protein
K04M1_RS01400	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
K04M1_RS01405	COG5016	pyruvate
K04M1_RS01405	COG0511	ligase activity, forming carbon-carbon bonds
K04M1_RS01410	COG3630	sodium ion export across plasma membrane
K04M1_RS01420	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
K04M1_RS01430	COG2301	Belongs to the HpcH HpaI aldolase family
K04M1_RS01435	COG3051	citrate lyase alpha subunit
K04M1_RS01445	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
K04M1_RS01460	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K04M1_RS01465	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
K04M1_RS01475	COG1609	Transcriptional regulator
K04M1_RS01480	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K04M1_RS01490	COG0254	rRNA binding
K04M1_RS01500	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K04M1_RS01505	COG0088	Forms part of the polypeptide exit tunnel
K04M1_RS01515	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K04M1_RS01520	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K04M1_RS01525	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K04M1_RS01530	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K04M1_RS01540	COG0255	Belongs to the universal ribosomal protein uL29 family
K04M1_RS01545	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K04M1_RS01555	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K04M1_RS01560	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K04M1_RS01565	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K04M1_RS01570	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K04M1_RS01575	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K04M1_RS01590	COG1841	ribosomal large subunit assembly
K04M1_RS01595	COG0200	Binds to the 23S rRNA
K04M1_RS01600	COG0201	protein transport
K04M1_RS01605	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K04M1_RS01610	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K04M1_RS01615	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K04M1_RS01625	COG0202	RNA polymerase activity
K04M1_RS01630	COG0203	ribosomal protein L17
K04M1_RS01640	COG0545	Peptidyl-prolyl cis-trans isomerase
K04M1_RS01650	COG2153	protein acetylation
K04M1_RS01655	COG0513	Belongs to the DEAD box helicase family
K04M1_RS01670	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K04M1_RS01670	COG1648	precorrin-2 dehydrogenase activity
K04M1_RS01675	COG0175	sulfate reduction
K04M1_RS01680	COG2895	sulfate adenylyltransferase (ATP) activity
K04M1_RS01685	COG3273	potassium ion transport
K04M1_RS01685	COG0471	metal ion transport
K04M1_RS01690	COG0529	Catalyzes the synthesis of activated sulfate
K04M1_RS01710	COG4181	ATPase activity
K04M1_RS01725	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
K04M1_RS01735	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K04M1_RS01740	COG0729	surface antigen
K04M1_RS01745	COG2911	Protein conserved in bacteria
K04M1_RS01750	COG2105	PFAM AIG2 family protein
K04M1_RS01760	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
K04M1_RS01765	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
K04M1_RS01775	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K04M1_RS01780	COG0163	prenyltransferase activity
K04M1_RS01785	COG4143	(ABC) transporter
K04M1_RS01790	COG1178	ABC-type Fe3 transport system permease component
K04M1_RS01795	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
K04M1_RS01800	COG0583	DNA-binding transcription factor activity
K04M1_RS01805	COG1902	pentaerythritol trinitrate reductase activity
K04M1_RS01825	COG2358	TRAP transporter, solute receptor (TAXI family
K04M1_RS01850	COG0142	geranyltranstransferase activity
K04M1_RS01855	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K04M1_RS01865	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K04M1_RS01870	COG2966	Psort location CytoplasmicMembrane, score
K04M1_RS01880	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
K04M1_RS01885	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
K04M1_RS01890	COG2967	ApaG domain
K04M1_RS01895	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K04M1_RS01900	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
K04M1_RS01905	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K04M1_RS01910	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
K04M1_RS01915	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
K04M1_RS01935	COG0473	3-isopropylmalate dehydrogenase activity
K04M1_RS01940	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K04M1_RS01965	COG0583	DNA-binding transcription factor activity
K04M1_RS01970	COG1022	Amp-dependent synthetase and ligase
K04M1_RS01975	COG0028	Belongs to the TPP enzyme family
K04M1_RS01980	COG0440	acetolactate synthase activity
K04M1_RS01995	COG0469	pyruvate kinase activity
K04M1_RS02000	COG1349	DNA-binding transcription factor activity
K04M1_RS02005	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K04M1_RS02015	COG2376	Dihydroxyacetone kinase
K04M1_RS02020	COG1461	Dihydroxyacetone kinase
K04M1_RS02035	COG3722	fumarate hydratase activity
K04M1_RS02045	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K04M1_RS02045	COG2213	PTS system mannitol-specific
K04M1_RS02080	COG0358	DNA primase activity
K04M1_RS02085	COG1610	YqeY-like protein
K04M1_RS02090	COG0828	Belongs to the bacterial ribosomal protein bS21 family
K04M1_RS02095	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K04M1_RS02100	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K04M1_RS02105	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
K04M1_RS02110	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
K04M1_RS02115	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K04M1_RS02120	COG1968	undecaprenyl-diphosphatase activity
K04M1_RS02130	COG3267	Type II secretory pathway component ExeA
K04M1_RS02130	COG3409	Peptidoglycan-binding domain 1 protein
K04M1_RS02140	COG0405	Gamma-glutamyltransferase
K04M1_RS02145	COG4991	sh3 domain protein
K04M1_RS02150	COG0306	phosphate transporter
K04M1_RS02155	COG1392	Phosphate transport regulator
K04M1_RS02160	COG3025	triphosphatase activity
K04M1_RS02175	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
K04M1_RS02180	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
K04M1_RS02180	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
K04M1_RS02185	COG1538	Outer membrane efflux protein
K04M1_RS02190	COG0494	nUDIX hydrolase
K04M1_RS02195	COG3151	Protein conserved in bacteria
K04M1_RS02205	COG3150	esterase
K04M1_RS02215	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K04M1_RS02220	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K04M1_RS02230	COG3105	Protein conserved in bacteria
K04M1_RS02240	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
K04M1_RS02255	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K04M1_RS02260	COG0723	plastoquinol--plastocyanin reductase activity
K04M1_RS02265	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K04M1_RS02270	COG2857	Cytochrome c1
K04M1_RS02275	COG0625	glutathione transferase activity
K04M1_RS02280	COG2969	positive regulation of protein catabolic process
K04M1_RS02290	COG2823	Periplasmic or secreted lipoprotein
K04M1_RS02295	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
K04M1_RS02310	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
K04M1_RS02330	COG3116	cell division
K04M1_RS02335	COG0768	penicillin binding
K04M1_RS02340	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K04M1_RS02345	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K04M1_RS02350	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K04M1_RS02355	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K04M1_RS02360	COG0772	Belongs to the SEDS family
K04M1_RS02375	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K04M1_RS02380	COG0849	cell division
K04M1_RS02385	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K04M1_RS02390	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
K04M1_RS02400	COG0653	protein targeting
K04M1_RS02405	COG0494	nUDIX hydrolase
K04M1_RS02415	COG0505	Belongs to the CarA family
K04M1_RS02420	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K04M1_RS02435	COG0730	response to heat
K04M1_RS02440	COG0583	DNA-binding transcription factor activity
K04M1_RS02445	COG2860	membrane
K04M1_RS02460	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K04M1_RS02470	COG0493	'glutamate synthase
K04M1_RS02475	COG0070	glutamate synthase
K04M1_RS02475	COG0069	glutamate synthase activity
K04M1_RS02475	COG0067	glutamate synthase
K04M1_RS02485	COG0069	glutamate synthase activity
K04M1_RS02485	COG0067	glutamate synthase
K04M1_RS02485	COG0070	glutamate synthase
K04M1_RS02490	COG1242	4 iron, 4 sulfur cluster binding
K04M1_RS02495	COG4251	negative regulation of phosphorylation
K04M1_RS02495	COG2203	Gaf domain
K04M1_RS02495	COG3706	GGDEF domain
K04M1_RS02495	COG5001	Diguanylate cyclase
K04M1_RS02500	COG0784	Response regulator, receiver
K04M1_RS02500	COG2198	Histidine kinase
K04M1_RS02500	COG5002	protein histidine kinase activity
K04M1_RS02510	COG0745	RESPONSE REGULATOR receiver
K04M1_RS02525	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K04M1_RS02545	COG0083	homoserine kinase activity
K04M1_RS02550	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
K04M1_RS02560	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
K04M1_RS02565	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
K04M1_RS02575	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K04M1_RS02590	COG1115	amino acid carrier protein
K04M1_RS02595	COG3022	response to hydroperoxide
K04M1_RS02600	COG0513	Belongs to the DEAD box helicase family
K04M1_RS02605	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
K04M1_RS02615	COG0716	FMN binding
K04M1_RS02620	COG4974	Belongs to the 'phage' integrase family
K04M1_RS02625	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K04M1_RS02630	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K04M1_RS02645	COG2204	response regulator
K04M1_RS02655	COG0667	Aldo Keto reductase
K04M1_RS02680	COG0730	response to heat
K04M1_RS02685	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K04M1_RS02690	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
K04M1_RS02700	COG1283	sodium-dependent phosphate transmembrane transporter activity
K04M1_RS02705	COG0583	DNA-binding transcription factor activity
K04M1_RS02710	COG0640	Transcriptional regulator
K04M1_RS02715	COG0268	Binds directly to 16S ribosomal RNA
K04M1_RS02720	COG0728	peptidoglycan biosynthetic process
K04M1_RS02725	COG0196	riboflavin kinase activity
K04M1_RS02740	COG1047	Peptidyl-prolyl cis-trans
K04M1_RS02745	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K04M1_RS02755	COG3279	Response regulator of the LytR AlgR family
K04M1_RS02760	COG3275	phosphorelay sensor kinase activity
K04M1_RS02765	COG1966	Carbon starvation protein
K04M1_RS02785	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
K04M1_RS02790	COG1472	Belongs to the glycosyl hydrolase 3 family
K04M1_RS02795	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K04M1_RS02800	COG1605	Chorismate mutase
K04M1_RS02800	COG0287	Prephenate dehydrogenase
K04M1_RS02805	COG0739	heme binding
K04M1_RS02815	COG0488	(ABC) transporter
K04M1_RS02825	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
K04M1_RS02830	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
K04M1_RS02835	COG0077	Prephenate dehydratase
K04M1_RS02835	COG1605	Chorismate mutase
K04M1_RS02840	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K04M1_RS02850	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K04M1_RS02855	COG0564	pseudouridine synthase activity
K04M1_RS02865	COG0542	response to heat
K04M1_RS02930	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K04M1_RS02935	COG0826	peptidase U32
K04M1_RS02940	COG2974	May be involved in recombination
K04M1_RS02950	COG0745	RESPONSE REGULATOR receiver
K04M1_RS02955	COG5002	protein histidine kinase activity
K04M1_RS02965	COG0248	Ppx GppA phosphatase
K04M1_RS02970	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K04M1_RS02975	COG0573	inorganic phosphate transmembrane transporter activity
K04M1_RS02980	COG0581	inorganic phosphate transmembrane transporter activity
K04M1_RS02985	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K04M1_RS02990	COG0704	Plays a role in the regulation of phosphate uptake
K04M1_RS03000	COG3142	Participates in the control of copper homeostasis
K04M1_RS03005	COG0450	alkyl hydroperoxide reductase
K04M1_RS03010	COG0583	DNA-binding transcription factor activity
K04M1_RS03015	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
K04M1_RS03025	COG0517	IMP dehydrogenase activity
K04M1_RS03035	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K04M1_RS03045	COG1862	Preprotein translocase
K04M1_RS03050	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K04M1_RS03055	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K04M1_RS03070	COG0483	inositol monophosphate 1-phosphatase activity
K04M1_RS03075	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
K04M1_RS03085	COG1104	cysteine desulfurase activity
K04M1_RS03090	COG0822	iron-sulfur transferase activity
K04M1_RS03105	COG0443	Heat shock 70 kDa protein
K04M1_RS03110	COG0633	Ferredoxin
K04M1_RS03115	COG2975	iron-sulfur cluster assembly
K04M1_RS03125	COG0105	UTP biosynthetic process
K04M1_RS03140	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K04M1_RS03145	COG0124	histidyl-tRNA synthetase
K04M1_RS03150	COG2976	Protein conserved in bacteria
K04M1_RS03155	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K04M1_RS03160	COG1160	GTP binding
K04M1_RS03180	COG0517	IMP dehydrogenase activity
K04M1_RS03180	COG0516	GMP reductase activity
K04M1_RS03190	COG0582	viral genome integration into host DNA
K04M1_RS03260	COG1757	Na H antiporter
K04M1_RS03270	COG1584	GPR1 FUN34 yaaH family protein
K04M1_RS03275	COG1115	amino acid carrier protein
K04M1_RS03290	COG2873	o-acetylhomoserine
K04M1_RS03295	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K04M1_RS03315	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K04M1_RS03315	COG3153	acetyltransferase
K04M1_RS03320	COG0583	DNA-binding transcription factor activity
K04M1_RS03345	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K04M1_RS03350	COG2867	negative regulation of translational initiation
K04M1_RS03355	COG2914	Belongs to the UPF0125 (RnfH) family
K04M1_RS03360	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K04M1_RS03370	COG0497	DNA recombination
K04M1_RS03380	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K04M1_RS03385	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K04M1_RS03390	COG1301	dicarboxylic acid transport
K04M1_RS03400	COG0484	heat shock protein binding
K04M1_RS03435	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
K04M1_RS03450	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
K04M1_RS03455	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K04M1_RS03455	COG0047	phosphoribosylformylglycinamidine synthase activity
K04M1_RS03485	COG2195	Cleaves the N-terminal amino acid of tripeptides
K04M1_RS03490	COG2252	PERMEase
K04M1_RS03495	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
K04M1_RS03500	COG1073	alpha beta
K04M1_RS03510	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K04M1_RS03515	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K04M1_RS03520	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K04M1_RS03525	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K04M1_RS03525	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K04M1_RS03540	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
K04M1_RS03550	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
K04M1_RS03555	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
K04M1_RS03560	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K04M1_RS03565	COG0142	geranyltranstransferase activity
K04M1_RS03570	COG1722	exodeoxyribonuclease VII activity
K04M1_RS03575	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K04M1_RS03585	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K04M1_RS03585	COG0301	tRNA thio-modification
K04M1_RS03590	COG0583	DNA-binding transcription factor activity
K04M1_RS03600	COG2363	Small membrane protein
K04M1_RS03610	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K04M1_RS03615	COG1611	Belongs to the LOG family
K04M1_RS03630	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K04M1_RS03630	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K04M1_RS03640	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
K04M1_RS03645	COG1464	Belongs to the NlpA lipoprotein family
K04M1_RS03650	COG2011	ABC-type metal ion transport system permease component
K04M1_RS03655	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K04M1_RS03665	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
K04M1_RS03675	COG1263	PTS System
K04M1_RS03675	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K04M1_RS03680	COG0366	Alpha amylase catalytic
K04M1_RS03695	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K04M1_RS03700	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K04M1_RS03705	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K04M1_RS03710	COG0321	lipoyl(octanoyl) transferase activity
K04M1_RS03720	COG1686	Belongs to the peptidase S11 family
K04M1_RS03725	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
K04M1_RS03730	COG0772	Belongs to the SEDS family
K04M1_RS03735	COG0768	penicillin binding
K04M1_RS03740	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K04M1_RS03745	COG0799	negative regulation of ribosome biogenesis
K04M1_RS03750	COG1466	dna polymerase III delta subunit
K04M1_RS03755	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
K04M1_RS03760	COG0495	leucyl-tRNA aminoacylation
K04M1_RS03765	COG2888	peptidyl-tyrosine sulfation
K04M1_RS03770	COG0815	Transfers the fatty acyl group on membrane lipoproteins
K04M1_RS03775	COG4535	Mg2 and Co2 transporter CorC
K04M1_RS03780	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K04M1_RS03785	COG1702	phosphate starvation-inducible protein PhoH
K04M1_RS03790	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K04M1_RS03800	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K04M1_RS03910	COG0012	GTP binding
K04M1_RS03915	COG0193	aminoacyl-tRNA hydrolase activity
K04M1_RS03920	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K04M1_RS03925	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K04M1_RS03930	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
K04M1_RS03935	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
K04M1_RS03945	COG2890	protein-(glutamine-N5) methyltransferase activity
K04M1_RS03950	COG3094	Invasion gene expression up-regulator, SirB
K04M1_RS03955	COG2912	Transglutaminase-like superfamily
K04M1_RS03960	COG2877	3-deoxy-8-phosphooctulonate synthase activity
K04M1_RS03965	COG0737	Belongs to the 5'-nucleotidase family
K04M1_RS03970	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K04M1_RS03975	COG1187	pseudouridine synthase activity
K04M1_RS03980	COG2840	Smr protein MutS2
K04M1_RS04020	COG2217	Heavy metal translocating P-type atpase
K04M1_RS04020	COG2608	mercury ion transmembrane transporter activity
K04M1_RS04035	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
K04M1_RS04090	COG0784	Response regulator, receiver
K04M1_RS04090	COG0835	chemotaxis
K04M1_RS04095	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
K04M1_RS04100	COG1815	bacterial-type flagellum-dependent cell motility
K04M1_RS04105	COG1558	bacterial-type flagellum-dependent cell motility
K04M1_RS04115	COG1749	Flagellar hook protein flgE
K04M1_RS04120	COG4787	bacterial-type flagellum-dependent cell motility
K04M1_RS04130	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
K04M1_RS04135	COG1706	bacterial-type flagellum-dependent cell motility
K04M1_RS04140	COG1705	Flagellar rod assembly protein muramidase FlgJ
K04M1_RS04140	COG3951	Flagellar rod assembly protein muramidase FlgJ
K04M1_RS04150	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K04M1_RS04155	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K04M1_RS04160	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K04M1_RS04165	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K04M1_RS04170	COG2190	(PTS) system
K04M1_RS04175	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K04M1_RS04180	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K04M1_RS04190	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K04M1_RS04195	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
K04M1_RS04200	COG3115	cell septum assembly
K04M1_RS04205	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K04M1_RS04225	COG0330	HflC and HflK could
K04M1_RS04230	COG2194	sulfuric ester hydrolase activity
K04M1_RS04245	COG1192	Involved in chromosome partitioning
K04M1_RS04250	COG1215	transferase activity, transferring glycosyl groups
K04M1_RS04260	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
K04M1_RS04265	COG3118	belongs to the thioredoxin family
K04M1_RS04265	COG0457	Tetratricopeptide repeat
K04M1_RS04270	COG3118	belongs to the thioredoxin family
K04M1_RS04280	COG0300	oxidoreductase activity
K04M1_RS04285	COG1090	epimerase
K04M1_RS04315	COG0622	Phosphoesterase
K04M1_RS04335	COG3710	Transcriptional regulator
K04M1_RS04340	COG0326	Molecular chaperone. Has ATPase activity
K04M1_RS04350	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
K04M1_RS04355	COG3104	oligopeptide transport
K04M1_RS04360	COG0250	Participates in transcription elongation, termination and antitermination
K04M1_RS04365	COG0367	asparagine synthase
K04M1_RS04370	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K04M1_RS04370	COG4651	solute:proton antiporter activity
K04M1_RS04375	COG1940	carbohydrate kinase activity
K04M1_RS04375	COG1846	Transcriptional regulator
K04M1_RS04380	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K04M1_RS04390	COG1263	PTS System
K04M1_RS04390	COG2190	(PTS) system
K04M1_RS04390	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K04M1_RS04395	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K04M1_RS04400	COG0735	belongs to the Fur family
K04M1_RS04410	COG0716	FMN binding
K04M1_RS04420	COG0596	Alpha beta hydrolase
K04M1_RS04425	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
K04M1_RS04430	COG0033	Phosphoglucomutase
K04M1_RS04440	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
K04M1_RS04455	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
K04M1_RS04460	COG1053	succinate dehydrogenase
K04M1_RS04465	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K04M1_RS04470	COG0567	Dehydrogenase, E1 component
K04M1_RS04475	COG0508	dehydrogenase complex catalyzes the overall conversion of
K04M1_RS04480	COG0045	succinate-CoA ligase (ADP-forming) activity
K04M1_RS04490	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K04M1_RS04495	COG1121	(ABC) transporter
K04M1_RS04500	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
K04M1_RS04505	COG4977	sequence-specific DNA binding
K04M1_RS04510	COG1918	ferrous iron import across plasma membrane
K04M1_RS04535	COG0018	arginyl-trna synthetase
K04M1_RS04545	COG3102	Protein conserved in bacteria
K04M1_RS04560	COG0788	formyltetrahydrofolate deformylase activity
K04M1_RS04565	COG1199	ATP-dependent helicase activity
K04M1_RS04570	COG1214	PFAM Peptidase M22, glycoprotease
K04M1_RS04580	COG3065	identical protein binding
K04M1_RS04585	COG2267	carboxylic ester hydrolase activity
K04M1_RS04590	COG0318	PFAM AMP-dependent synthetase and ligase
K04M1_RS04595	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
K04M1_RS04600	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
K04M1_RS04605	COG2894	cell division
K04M1_RS04610	COG0850	regulation of cytokinetic process
K04M1_RS04615	COG3100	YcgL domain-containing protein
K04M1_RS04620	COG2951	lytic endotransglycosylase activity
K04M1_RS04630	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K04M1_RS04635	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K04M1_RS04645	COG2226	methyltransferase
K04M1_RS04655	COG1028	Short-chain dehydrogenase reductase Sdr
K04M1_RS04665	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K04M1_RS04690	COG2986	histidine ammonia-lyase
K04M1_RS04695	COG1216	Glycosyl transferase, family 2
K04M1_RS04700	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K04M1_RS04715	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K04M1_RS04720	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K04M1_RS04755	COG0513	Belongs to the DEAD box helicase family
K04M1_RS04760	COG0569	domain protein
K04M1_RS04765	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K04M1_RS04780	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
K04M1_RS04785	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K04M1_RS04790	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K04M1_RS04795	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K04M1_RS04820	COG0544	peptidyl-prolyl cis-trans isomerase activity
K04M1_RS04830	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K04M1_RS04835	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K04M1_RS04840	COG0776	regulation of translation
K04M1_RS04845	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K04M1_RS04850	COG1555	photosystem II stabilization
K04M1_RS04865	COG0232	Belongs to the dGTPase family. Type 2 subfamily
K04M1_RS04870	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
K04M1_RS04875	COG0436	Aminotransferase
K04M1_RS04880	COG1169	isochorismate synthase
K04M1_RS04885	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
K04M1_RS04895	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
K04M1_RS04915	COG2855	membrane
K04M1_RS04920	COG0477	Major facilitator Superfamily
K04M1_RS04965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K04M1_RS04970	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K04M1_RS04985	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K04M1_RS04990	COG1522	sequence-specific DNA binding
K04M1_RS05000	COG1946	Acyl-CoA thioesterase
K04M1_RS05005	COG3126	Type III secretion system lipoprotein chaperone (YscW)
K04M1_RS05030	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K04M1_RS05035	COG0516	GMP reductase activity
K04M1_RS05035	COG0517	IMP dehydrogenase activity
K04M1_RS05060	COG0537	adenosine 5'-monophosphoramidase activity
K04M1_RS05085	COG3150	esterase
K04M1_RS05090	COG1252	NADH dehydrogenase
K04M1_RS05105	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K04M1_RS05115	COG4591	ABC-type transport system involved in lipoprotein release permease component
K04M1_RS05120	COG1136	(ABC) transporter
K04M1_RS05125	COG4591	ABC-type transport system involved in lipoprotein release permease component
K04M1_RS05135	COG2333	competence protein COMEC
K04M1_RS05135	COG0658	competence protein
K04M1_RS05140	COG1132	(ABC) transporter
K04M1_RS05160	COG2719	SpoVR family
K04M1_RS05165	COG2718	Belongs to the UPF0229 family
K04M1_RS05170	COG2766	serine protein kinase
K04M1_RS05180	COG3013	Belongs to the UPF0304 family
K04M1_RS05190	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K04M1_RS05200	COG1882	Formate acetyltransferase
K04M1_RS05245	COG0708	Exodeoxyribonuclease III
K04M1_RS05255	COG3923	Primosomal replication protein n
K04M1_RS05260	COG0730	response to heat
K04M1_RS05265	COG1199	ATP-dependent helicase activity
K04M1_RS05275	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K04M1_RS05280	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
K04M1_RS05285	COG1187	pseudouridine synthase activity
K04M1_RS05295	COG1278	Cold shock
K04M1_RS05300	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
K04M1_RS05305	COG0542	response to heat
K04M1_RS05310	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K04M1_RS05315	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
K04M1_RS05320	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
K04M1_RS05340	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K04M1_RS05345	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K04M1_RS05350	COG0297	glycogen (starch) synthase activity
K04M1_RS05370	COG3070	regulator of competence-specific genes
K04M1_RS05375	COG1609	Transcriptional regulator
K04M1_RS05380	COG3381	protein complex oligomerization
K04M1_RS05385	COG0745	RESPONSE REGULATOR receiver
K04M1_RS05390	COG1434	Gram-negative-bacterium-type cell wall biogenesis
K04M1_RS05395	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K04M1_RS05400	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
K04M1_RS05405	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
K04M1_RS05410	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K04M1_RS05430	COG0189	ligase activity
K04M1_RS05430	COG4067	protein conserved in archaea
K04M1_RS05440	COG0500	methyltransferase
K04M1_RS05450	COG1801	Protein of unknown function DUF72
K04M1_RS05460	COG0217	transcriptional regulatory protein
K04M1_RS05465	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
K04M1_RS05470	COG0632	four-way junction helicase activity
K04M1_RS05475	COG2255	four-way junction helicase activity
K04M1_RS05480	COG1271	oxidase subunit
K04M1_RS05485	COG1294	oxidase, subunit
K04M1_RS05490	COG4890	Cyd operon protein YbgT
K04M1_RS05500	COG0824	Thioesterase
K04M1_RS05505	COG0811	peptide transport
K04M1_RS05520	COG0823	Involved in the tonB-independent uptake of proteins
K04M1_RS05525	COG2885	chlorophyll binding
K04M1_RS05530	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
K04M1_RS05535	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
K04M1_RS05545	COG3766	membrane
K04M1_RS05555	COG0754	glutathionylspermidine amidase activity
K04M1_RS05565	COG0784	Response regulator, receiver
K04M1_RS05565	COG5002	protein histidine kinase activity
K04M1_RS05580	COG1294	oxidase, subunit
K04M1_RS05585	COG1271	oxidase subunit
K04M1_RS05610	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K04M1_RS05615	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K04M1_RS05640	COG3568	Endonuclease Exonuclease Phosphatase
K04M1_RS05665	COG0583	DNA-binding transcription factor activity
K04M1_RS05675	COG0686	Belongs to the AlaDH PNT family
K04M1_RS05685	COG1674	ftsk spoiiie
K04M1_RS05695	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K04M1_RS05715	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K04M1_RS05720	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K04M1_RS05740	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
K04M1_RS05760	COG0300	oxidoreductase activity
K04M1_RS05775	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K04M1_RS05785	COG2268	Band 7 protein
K04M1_RS05795	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K04M1_RS05800	COG2915	High frequency lysogenization protein hflD homolog
K04M1_RS05815	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K04M1_RS05825	COG1757	Na H antiporter
K04M1_RS05835	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K04M1_RS05845	COG0131	Imidazoleglycerol-phosphate dehydratase
K04M1_RS05845	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
K04M1_RS05850	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
K04M1_RS05855	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K04M1_RS05865	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K04M1_RS05865	COG0140	phosphoribosyl-ATP diphosphatase activity
K04M1_RS05870	COG3012	SEC-C Motif Domain Protein
K04M1_RS05875	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
K04M1_RS05880	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K04M1_RS05885	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K04M1_RS05890	COG0215	cysteine-tRNA ligase activity
K04M1_RS05895	COG1435	thymidine kinase activity
K04M1_RS05925	COG2116	formate transmembrane transporter activity
K04M1_RS05935	COG0390	transport system, permease component
K04M1_RS05940	COG4459	periplasmic nitrate reductase
K04M1_RS05945	COG3005	denitrification pathway
K04M1_RS05950	COG0243	molybdopterin cofactor binding
K04M1_RS05965	COG1227	inorganic diphosphatase activity
K04M1_RS05975	COG4172	Belongs to the ABC transporter superfamily
K04M1_RS05985	COG4171	peptide transport system, permease
K04M1_RS06000	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
K04M1_RS06005	COG1842	Phage shock protein A
K04M1_RS06015	COG1983	PspC domain protein
K04M1_RS06035	COG2818	Glycosylase
K04M1_RS06040	COG5380	lipid catabolic process
K04M1_RS06045	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
K04M1_RS06050	COG0626	cystathionine gamma-synthase activity
K04M1_RS06060	COG0733	neurotransmitter:sodium symporter activity
K04M1_RS06065	COG0564	pseudouridine synthase activity
K04M1_RS06075	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K04M1_RS06080	COG1151	hydroxylamine reductase activity
K04M1_RS06085	COG3604	Transcriptional regulator
K04M1_RS06100	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K04M1_RS06105	COG4136	ATPase activity
K04M1_RS06110	COG4135	transport system, permease component
K04M1_RS06115	COG4134	Bacterial extracellular solute-binding protein
K04M1_RS06125	COG3313	Fe-S protein
K04M1_RS06150	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
K04M1_RS06170	COG1061	Type III restriction enzyme res subunit
K04M1_RS06175	COG1187	pseudouridine synthase activity
K04M1_RS06185	COG2814	Major facilitator Superfamily
K04M1_RS06195	COG0702	epimerase
K04M1_RS06200	COG0534	Mate efflux family protein
K04M1_RS06220	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K04M1_RS06235	COG1960	acyl-CoA dehydrogenase activity
K04M1_RS06240	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K04M1_RS06245	COG3273	potassium ion transport
K04M1_RS06245	COG2985	domain, Protein
K04M1_RS06250	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K04M1_RS06260	COG1737	Transcriptional regulator
K04M1_RS06265	COG0076	glutamate decarboxylase activity
K04M1_RS06275	COG2431	L-lysine efflux transmembrane transporter activity
K04M1_RS06295	COG3070	regulator of competence-specific genes
K04M1_RS06310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K04M1_RS06310	COG4191	Histidine kinase
K04M1_RS06320	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
K04M1_RS06330	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
K04M1_RS06335	COG4988	ABC transporter
K04M1_RS06340	COG0492	ferredoxin-NADP+ reductase activity
K04M1_RS06365	COG0471	metal ion transport
K04M1_RS06370	COG2949	membrane
K04M1_RS06375	COG0281	malic enzyme
K04M1_RS06380	COG1643	Atp-dependent helicase
K04M1_RS06395	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K04M1_RS06430	COG0277	FAD linked oxidase domain protein
K04M1_RS06430	COG0247	lactate metabolic process
K04M1_RS06445	COG2986	histidine ammonia-lyase
K04M1_RS06450	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
K04M1_RS06455	COG0010	Belongs to the arginase family
K04M1_RS06460	COG1228	amidohydrolase
K04M1_RS06465	COG2188	Transcriptional regulator
K04M1_RS06480	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K04M1_RS06490	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K04M1_RS06500	COG0393	Putative heavy-metal-binding
K04M1_RS06535	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K04M1_RS06540	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K04M1_RS06540	COG0072	phenylalanine-tRNA ligase activity
K04M1_RS06550	COG0776	regulation of translation
K04M1_RS06560	COG0500	methyltransferase
K04M1_RS06565	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
K04M1_RS06570	COG0295	cytidine deaminase activity
K04M1_RS06575	COG1346	cytolysis
K04M1_RS06580	COG1380	Effector of murein hydrolase LrgA
K04M1_RS06585	COG2925	Exonuclease
K04M1_RS06640	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K04M1_RS06670	COG1484	DNA-dependent DNA replication
K04M1_RS06815	COG1823	symporter activity
K04M1_RS06820	COG0702	epimerase
K04M1_RS06825	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
K04M1_RS06830	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
K04M1_RS06850	COG2988	succinylglutamate desuccinylase activity
K04M1_RS06855	COG4139	cobalamin transport
K04M1_RS06860	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
K04M1_RS06880	COG0583	DNA-binding transcription factor activity
K04M1_RS06890	COG1451	nucleotide metabolic process
K04M1_RS06895	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
K04M1_RS06925	COG3938	Belongs to the proline racemase family
K04M1_RS06940	COG2423	ornithine cyclodeaminase activity
K04M1_RS06945	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K04M1_RS06950	COG3842	ATPase activity
K04M1_RS06955	COG1176	ABC-type spermidine putrescine transport system, permease component I
K04M1_RS06960	COG1177	transmembrane transport
K04M1_RS06970	COG3291	Pkd domain containing protein
K04M1_RS06990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K04M1_RS06995	COG0601	transmembrane transport
K04M1_RS07005	COG2195	Cleaves the N-terminal amino acid of tripeptides
K04M1_RS07015	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
K04M1_RS07025	COG0625	glutathione transferase activity
K04M1_RS07075	COG3755	Protein conserved in bacteria
K04M1_RS07100	COG1742	UPF0060 membrane protein
K04M1_RS07115	COG1757	Na H antiporter
K04M1_RS07120	COG0174	glutamine synthetase
K04M1_RS07130	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
K04M1_RS07135	COG1917	Cupin 2, conserved barrel domain protein
K04M1_RS07135	COG1396	sequence-specific DNA binding
K04M1_RS07140	COG1012	belongs to the aldehyde dehydrogenase family
K04M1_RS07145	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K04M1_RS07155	COG2957	Belongs to the agmatine deiminase family
K04M1_RS07160	COG1012	belongs to the aldehyde dehydrogenase family
K04M1_RS07165	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K04M1_RS07170	COG2200	EAL domain
K04M1_RS07180	COG1846	Transcriptional regulator
K04M1_RS07185	COG2315	Protein conserved in bacteria
K04M1_RS07225	COG3063	Type IV pilus biogenesis stability protein PilW
K04M1_RS07230	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
K04M1_RS07245	COG1560	Kdo2-lipid A biosynthetic process
K04M1_RS07255	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K04M1_RS07380	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
K04M1_RS07385	COG1280	lysine exporter protein (LysE YggA)
K04M1_RS07395	COG1115	amino acid carrier protein
K04M1_RS07420	COG1368	sulfuric ester hydrolase activity
K04M1_RS07425	COG2113	Glycine betaine
K04M1_RS07430	COG4176	ABC-type proline glycine betaine transport system permease component
K04M1_RS07435	COG4175	Glycine betaine
K04M1_RS07450	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K04M1_RS07455	COG0456	acetyltransferase
K04M1_RS07460	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K04M1_RS07465	COG0662	Cupin 2, conserved barrel domain protein
K04M1_RS07470	COG0527	aspartate kinase activity
K04M1_RS07475	COG3119	arylsulfatase activity
K04M1_RS07490	COG0641	radical SAM
K04M1_RS07505	COG3119	arylsulfatase activity
K04M1_RS07530	COG1538	Outer membrane efflux protein
K04M1_RS07545	COG1349	DNA-binding transcription factor activity
K04M1_RS07550	COG0673	inositol 2-dehydrogenase activity
K04M1_RS07555	COG4702	Belongs to the UPF0303 family
K04M1_RS07580	COG0471	metal ion transport
K04M1_RS07595	COG3300	MHYT domain
K04M1_RS07595	COG5001	Diguanylate cyclase
K04M1_RS07610	COG1328	CTP reductase activity
K04M1_RS07615	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K04M1_RS07625	COG0861	Integral membrane protein TerC family
K04M1_RS07635	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
K04M1_RS07645	COG0814	amino acid
K04M1_RS07660	COG1120	ATPase activity
K04M1_RS07665	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K04M1_RS07675	COG4774	siderophore transport
K04M1_RS07685	COG1132	(ABC) transporter
K04M1_RS07690	COG1132	(ABC) transporter
K04M1_RS07705	COG0583	DNA-binding transcription factor activity
K04M1_RS07730	COG0443	Heat shock 70 kDa protein
K04M1_RS07735	COG0443	Heat shock 70 kDa protein
K04M1_RS07780	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
K04M1_RS07785	COG1643	Atp-dependent helicase
K04M1_RS07800	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K04M1_RS07810	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K04M1_RS07815	COG1215	transferase activity, transferring glycosyl groups
K04M1_RS07820	COG0438	transferase activity, transferring glycosyl groups
K04M1_RS07850	COG0438	transferase activity, transferring glycosyl groups
K04M1_RS07855	COG0438	transferase activity, transferring glycosyl groups
K04M1_RS07860	COG2204	response regulator
K04M1_RS07895	COG1793	dna ligase
K04M1_RS07905	COG0534	Mate efflux family protein
K04M1_RS07910	COG0307	riboflavin synthase, alpha
K04M1_RS07920	COG3001	Fructosamine kinase
K04M1_RS07930	COG3706	GGDEF domain
K04M1_RS07940	COG0791	NLP P60 protein
K04M1_RS07975	COG3148	PFAM DTW domain containing protein
K04M1_RS07980	COG1940	carbohydrate kinase activity
K04M1_RS07995	COG0746	molybdenum cofactor guanylyltransferase activity
K04M1_RS08000	COG3842	ATPase activity
K04M1_RS08015	COG2204	response regulator
K04M1_RS08020	COG4191	Histidine kinase
K04M1_RS08030	COG0488	(ABC) transporter
K04M1_RS08035	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K04M1_RS08055	COG3381	protein complex oligomerization
K04M1_RS08065	COG3383	formate dehydrogenase (NAD+) activity
K04M1_RS08065	COG0243	molybdopterin cofactor binding
K04M1_RS08070	COG0437	4 iron, 4 sulfur cluster binding
K04M1_RS08100	COG0004	ammonium transporteR
K04M1_RS08105	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K04M1_RS08110	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K04M1_RS08120	COG1177	transmembrane transport
K04M1_RS08130	COG3842	ATPase activity
K04M1_RS08155	COG0589	response to stress
K04M1_RS08160	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K04M1_RS08175	COG2217	Heavy metal translocating P-type atpase
K04M1_RS08185	COG2010	Cytochrome c
K04M1_RS08200	COG3278	Belongs to the heme-copper respiratory oxidase family
K04M1_RS08215	COG2205	protein histidine kinase activity
K04M1_RS08215	COG0784	Response regulator, receiver
K04M1_RS08235	COG3120	sequence-specific DNA binding
K04M1_RS08240	COG1067	ATP-dependent peptidase activity
K04M1_RS08245	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K04M1_RS08260	COG0488	(ABC) transporter
K04M1_RS08270	COG0116	Belongs to the methyltransferase superfamily
K04M1_RS08270	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K04M1_RS08280	COG0167	dihydroorotate dehydrogenase activity
K04M1_RS08285	COG2902	Dehydrogenase
K04M1_RS08295	COG0308	aminopeptidase N
K04M1_RS08310	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
K04M1_RS08315	COG1956	GAF domain-containing protein
K04M1_RS08320	COG1132	(ABC) transporter
K04M1_RS08325	COG2995	paraquat-inducible protein a
K04M1_RS08330	COG3008	intermembrane lipid transfer
K04M1_RS08355	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K04M1_RS08360	COG1666	GTP binding
K04M1_RS08375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K04M1_RS08380	COG4597	amino acid ABC transporter
K04M1_RS08385	COG0765	amino acid transport
K04M1_RS08390	COG1126	abc transporter atp-binding protein
K04M1_RS08395	COG0670	Belongs to the BI1 family
K04M1_RS08410	COG2920	part of a sulfur-relay system
K04M1_RS08415	COG1254	Belongs to the acylphosphatase family
K04M1_RS08420	COG0840	transmembrane signaling receptor activity
K04M1_RS08440	COG2885	chlorophyll binding
K04M1_RS08465	COG2199	diguanylate cyclase activity
K04M1_RS08465	COG2203	Gaf domain
K04M1_RS08470	COG1414	Transcriptional regulator
K04M1_RS08480	COG0656	L-ascorbic acid biosynthetic process
K04M1_RS08485	COG0583	DNA-binding transcription factor activity
K04M1_RS08495	COG0583	DNA-binding transcription factor activity
K04M1_RS08500	COG2814	Major facilitator Superfamily
K04M1_RS08520	COG1335	isochorismatase
K04M1_RS08525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K04M1_RS08540	COG0646	methionine synthase
K04M1_RS08540	COG1410	methionine synthase
K04M1_RS08545	COG1126	abc transporter atp-binding protein
K04M1_RS08550	COG0765	amino acid transport
K04M1_RS08555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K04M1_RS08570	COG0583	DNA-binding transcription factor activity
K04M1_RS08585	COG0583	DNA-binding transcription factor activity
K04M1_RS08595	COG0583	DNA-binding transcription factor activity
K04M1_RS08610	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
K04M1_RS08615	COG0602	queuosine metabolic process
K04M1_RS08620	COG0561	phosphatase activity
K04M1_RS08645	COG2828	Protein conserved in bacteria
K04M1_RS08655	COG0372	Belongs to the citrate synthase family
K04M1_RS08660	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
K04M1_RS08695	COG0730	response to heat
K04M1_RS08700	COG2358	TRAP transporter, solute receptor (TAXI family
K04M1_RS08715	COG0457	Tetratricopeptide repeat
K04M1_RS08785	COG4790	Type iii secretion
K04M1_RS08790	COG4794	Type iii secretion
K04M1_RS08795	COG4791	protein targeting
K04M1_RS08800	COG4792	protein secretion
K04M1_RS08805	COG2207	Transcriptional regulator
K04M1_RS08835	COG3177	Filamentation induced by cAMP protein fic
K04M1_RS08855	COG4669	(LipO)protein
K04M1_RS08925	COG1012	belongs to the aldehyde dehydrogenase family
K04M1_RS08930	COG3284	Transcriptional regulator
K04M1_RS08945	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
K04M1_RS08950	COG0363	glucosamine-6-phosphate deaminase activity
K04M1_RS08955	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K04M1_RS08960	COG2207	Transcriptional regulator
K04M1_RS08970	COG4565	transcriptional regulatory protein
K04M1_RS08975	COG3290	protein histidine kinase activity
K04M1_RS08990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K04M1_RS09005	COG0583	DNA-binding transcription factor activity
K04M1_RS09020	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
K04M1_RS09030	COG2985	domain, Protein
K04M1_RS09055	COG2272	Belongs to the type-B carboxylesterase lipase family
K04M1_RS09065	COG0729	surface antigen
K04M1_RS09075	COG1280	lysine exporter protein (LysE YggA)
K04M1_RS09080	COG1280	lysine exporter protein (LysE YggA)
K04M1_RS09085	COG5507	3-demethylubiquinone-9 3-methyltransferase
K04M1_RS09105	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K04M1_RS09115	COG0110	maltose O-acetyltransferase activity
K04M1_RS09165	COG2801	Transposase and inactivated derivatives
K04M1_RS09205	COG1683	Conserved Protein
K04M1_RS09290	COG2801	Transposase and inactivated derivatives
K04M1_RS09325	COG1403	HNH endonuclease
K04M1_RS09425	COG4974	Belongs to the 'phage' integrase family
K04M1_RS09435	COG3706	GGDEF domain
K04M1_RS09450	COG2985	domain, Protein
K04M1_RS09455	COG0076	glutamate decarboxylase activity
K04M1_RS09460	COG2963	transposase activity
K04M1_RS09465	COG0598	Magnesium transport protein CorA
K04M1_RS09475	COG0387	Pfam Sodium calcium exchanger
K04M1_RS09480	COG0387	Pfam Sodium calcium exchanger
K04M1_RS09495	COG1289	transmembrane transporter activity
K04M1_RS09510	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
K04M1_RS09520	COG2985	domain, Protein
K04M1_RS09525	COG0025	NhaP-type Na H and K H
K04M1_RS09555	COG3302	dmso reductase anchor subunit
K04M1_RS09560	COG0437	4 iron, 4 sulfur cluster binding
K04M1_RS09565	COG0243	molybdopterin cofactor binding
K04M1_RS09575	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K04M1_RS09575	COG2221	Nitrite and sulphite reductase 4Fe-4S
K04M1_RS09580	COG2205	protein histidine kinase activity
K04M1_RS09580	COG0784	Response regulator, receiver
K04M1_RS09650	COG3477	response to acidic pH
K04M1_RS09655	COG2200	EAL domain
K04M1_RS09655	COG2199	diguanylate cyclase activity
K04M1_RS09655	COG3287	FIST C domain
K04M1_RS09660	COG2197	response regulator
K04M1_RS09735	COG1472	Belongs to the glycosyl hydrolase 3 family
K04M1_RS09745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K04M1_RS09745	COG2205	protein histidine kinase activity
K04M1_RS09750	COG2197	response regulator
K04M1_RS09820	COG1335	isochorismatase
K04M1_RS09935	COG4628	conserved protein (DUF2132)
K04M1_RS09985	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K04M1_RS09995	COG3768	UPF0283 membrane protein
K04M1_RS10000	COG3106	COG3106 Predicted ATPase
K04M1_RS10020	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K04M1_RS10025	COG2205	protein histidine kinase activity
K04M1_RS10025	COG0784	Response regulator, receiver
K04M1_RS10035	COG0494	nUDIX hydrolase
K04M1_RS10040	COG0814	amino acid
K04M1_RS10045	COG1760	l-serine dehydratase
K04M1_RS10050	COG2200	EAL domain
K04M1_RS10060	COG0720	synthase
K04M1_RS10065	COG0840	transmembrane signaling receptor activity
K04M1_RS10070	COG0017	Asparaginyl-tRNA synthetase
K04M1_RS10080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K04M1_RS10095	COG1448	Aminotransferase
K04M1_RS10115	COG0840	transmembrane signaling receptor activity
K04M1_RS10120	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K04M1_RS10150	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
K04M1_RS10165	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K04M1_RS10170	COG3108	Peptidase M15
K04M1_RS10175	COG2989	Protein conserved in bacteria
K04M1_RS10200	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K04M1_RS10210	COG4235	cytochrome complex assembly
K04M1_RS10210	COG3088	subunit of a heme lyase
K04M1_RS10220	COG1138	Cytochrome C-type biogenesis protein
K04M1_RS10225	COG3301	Polysulphide reductase, NrfD
K04M1_RS10230	COG0437	4 iron, 4 sulfur cluster binding
K04M1_RS10240	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
K04M1_RS10260	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K04M1_RS10265	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K04M1_RS10295	COG0019	diaminopimelate decarboxylase activity
K04M1_RS10335	COG0322	excinuclease ABC activity
K04M1_RS10340	COG2197	response regulator
K04M1_RS10345	COG0417	DNA replication proofreading
K04M1_RS10365	COG1187	pseudouridine synthase activity
K04M1_RS10375	COG0009	L-threonylcarbamoyladenylate synthase
K04M1_RS10380	COG0613	PHP domain protein
K04M1_RS10390	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K04M1_RS10395	COG0512	Glutamine amidotransferase of anthranilate synthase
K04M1_RS10405	COG0134	indole-3-glycerol-phosphate synthase activity
K04M1_RS10405	COG0135	phosphoribosylanthranilate isomerase activity
K04M1_RS10415	COG0159	tryptophan synthase activity
K04M1_RS10420	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K04M1_RS10425	COG0318	PFAM AMP-dependent synthetase and ligase
K04M1_RS10435	COG1301	dicarboxylic acid transport
K04M1_RS10455	COG2917	probably involved in intracellular septation
K04M1_RS10465	COG2350	Protein conserved in bacteria
K04M1_RS10475	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
K04M1_RS10480	COG0583	DNA-binding transcription factor activity
K04M1_RS10495	COG5001	Diguanylate cyclase
K04M1_RS10500	COG1032	radical SAM domain protein
K04M1_RS10520	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
K04M1_RS10525	COG0463	Glycosyl transferase, family 2
K04M1_RS10530	COG0745	RESPONSE REGULATOR receiver
K04M1_RS10535	COG3850	Histidine kinase
K04M1_RS10535	COG5002	protein histidine kinase activity
K04M1_RS10585	COG0577	efflux transmembrane transporter activity
K04M1_RS10585	COG1136	(ABC) transporter
K04M1_RS10590	COG1136	(ABC) transporter
K04M1_RS10590	COG0577	efflux transmembrane transporter activity
K04M1_RS10595	COG1136	(ABC) transporter
K04M1_RS10595	COG0577	efflux transmembrane transporter activity
K04M1_RS10605	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K04M1_RS10630	COG3118	belongs to the thioredoxin family
K04M1_RS10635	COG4232	protein-disulfide reductase activity
K04M1_RS10670	COG2863	cytochrome
K04M1_RS10675	COG3258	Cytochrome c
K04M1_RS10680	COG2995	paraquat-inducible protein a
K04M1_RS10685	COG3008	intermembrane lipid transfer
K04M1_RS10685	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K04M1_RS10705	COG4166	transmembrane transport
K04M1_RS10715	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
K04M1_RS10720	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
K04M1_RS10730	COG0539	negative regulation of cytoplasmic translation
K04M1_RS10735	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K04M1_RS10740	COG0616	signal peptide processing
K04M1_RS10745	COG1028	Short-chain dehydrogenase reductase Sdr
K04M1_RS10760	COG0587	DNA-directed DNA polymerase activity
K04M1_RS10765	COG0784	Response regulator, receiver
K04M1_RS10765	COG0835	chemotaxis
K04M1_RS10770	COG1940	carbohydrate kinase activity
K04M1_RS10775	COG0469	pyruvate kinase activity
K04M1_RS10780	COG4667	esterase of the alpha-beta hydrolase superfamily
K04M1_RS10795	COG0733	neurotransmitter:sodium symporter activity
K04M1_RS10810	COG1263	PTS System
K04M1_RS10810	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K04M1_RS10815	COG0084	hydrolase, TatD family'
K04M1_RS10820	COG0470	DNA polymerase III
K04M1_RS10825	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K04M1_RS10830	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K04M1_RS10860	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K04M1_RS10865	COG0416	fatty acid biosynthetic process
K04M1_RS10875	COG1399	metal-binding, possibly nucleic acid-binding protein
K04M1_RS10880	COG0424	maF-like protein
K04M1_RS10885	COG0564	pseudouridine synthase activity
K04M1_RS10895	COG1530	ribonuclease E activity
K04M1_RS10905	COG0659	secondary active sulfate transmembrane transporter activity
K04M1_RS10910	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K04M1_RS10915	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
K04M1_RS10925	COG0572	uridine kinase
K04M1_RS10935	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K04M1_RS10935	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K04M1_RS10955	COG2186	Transcriptional regulator
K04M1_RS10960	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K04M1_RS10965	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
K04M1_RS10970	COG3012	SEC-C Motif Domain Protein
K04M1_RS10970	COG3318	Belongs to the UPF0149 family
K04M1_RS10975	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K04M1_RS10980	COG3706	GGDEF domain
K04M1_RS10985	COG0366	Alpha amylase catalytic
K04M1_RS10990	COG1122	ATPase activity
K04M1_RS10995	COG4120	Belongs to the binding-protein-dependent transport system permease family
K04M1_RS11005	COG3092	negative regulation of chromosome organization
K04M1_RS11010	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K04M1_RS11015	COG0280	phosphate acetyltransferase
K04M1_RS11015	COG0857	belongs to the CobB CobQ family
K04M1_RS11025	COG0435	Glutathione S-transferase
K04M1_RS11035	COG0444	Belongs to the ABC transporter superfamily
K04M1_RS11040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K04M1_RS11045	COG0601	transmembrane transport
K04M1_RS11055	COG0314	molybdopterin synthase activity
K04M1_RS11060	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
K04M1_RS11065	COG0315	cyclic pyranopterin monophosphate synthase activity
K04M1_RS11070	COG0521	Mo-molybdopterin cofactor biosynthetic process
K04M1_RS11075	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K04M1_RS11080	COG0391	Required for morphogenesis under gluconeogenic growth conditions
K04M1_RS11085	COG2198	Histidine kinase
K04M1_RS11090	COG2204	response regulator
K04M1_RS11095	COG0556	nucleotide-excision repair
K04M1_RS11105	COG1882	Formate acetyltransferase
K04M1_RS11110	COG4657	Part of a membrane complex involved in electron transport
K04M1_RS11115	COG2878	Part of a membrane complex involved in electron transport
K04M1_RS11120	COG4656	Part of a membrane complex involved in electron transport
K04M1_RS11125	COG4658	electron transport chain
K04M1_RS11130	COG4659	FMN binding
K04M1_RS11135	COG4660	Part of a membrane complex involved in electron transport
K04M1_RS11140	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K04M1_RS11145	COG0346	lactoylglutathione lyase activity
K04M1_RS11155	COG2885	chlorophyll binding
K04M1_RS11165	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K04M1_RS11170	COG2056	Na+-H+ antiporter family
K04M1_RS11190	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
K04M1_RS11215	COG1012	belongs to the aldehyde dehydrogenase family
K04M1_RS11215	COG1454	alcohol dehydrogenase
K04M1_RS11220	COG2095	MarC family integral membrane protein
K04M1_RS11225	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K04M1_RS11230	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K04M1_RS11235	COG1757	Na H antiporter
K04M1_RS11250	COG3081	Nucleoid-associated protein
K04M1_RS11255	COG3082	Protein of unknown function (DUF1414)
K04M1_RS11270	COG0123	including yeast histone deacetylase and acetoin utilization protein
K04M1_RS11285	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K04M1_RS11290	COG0778	Nitroreductase
K04M1_RS11300	COG0446	pyridine nucleotide-disulphide oxidoreductase
K04M1_RS11300	COG1902	pentaerythritol trinitrate reductase activity
K04M1_RS11305	COG0616	signal peptide processing
K04M1_RS11310	COG0252	asparaginase activity
K04M1_RS11315	COG3139	Protein of unknown function (DUF1315)
K04M1_RS11325	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K04M1_RS11330	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K04M1_RS11345	COG2226	methyltransferase
K04M1_RS11365	COG1785	Belongs to the alkaline phosphatase family
K04M1_RS11375	COG0346	lactoylglutathione lyase activity
K04M1_RS11380	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
K04M1_RS11385	COG0668	transmembrane transport
K04M1_RS11390	COG2983	Belongs to the UPF0260 family
K04M1_RS11395	COG2261	transglycosylase associated protein
K04M1_RS11405	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K04M1_RS11410	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K04M1_RS11425	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K04M1_RS11430	COG2832	Protein of unknown function (DUF454)
K04M1_RS11440	COG0745	RESPONSE REGULATOR receiver
K04M1_RS11445	COG0583	DNA-binding transcription factor activity
K04M1_RS11450	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
K04M1_RS11455	COG1286	toxin biosynthetic process
K04M1_RS11460	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
K04M1_RS11465	COG0285	dihydrofolate synthase activity
K04M1_RS11470	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K04M1_RS11480	COG0101	tRNA pseudouridine synthase activity
K04M1_RS11490	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K04M1_RS11495	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K04M1_RS11505	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K04M1_RS11510	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
K04M1_RS11510	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K04M1_RS11515	COG0431	NADPH-dependent FMN reductase
K04M1_RS11530	COG3101	peptidyl-lysine hydroxylation
K04M1_RS11540	COG2860	membrane
K04M1_RS11545	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K04M1_RS11550	COG2890	protein-(glutamine-N5) methyltransferase activity
K04M1_RS11555	COG2840	Smr protein MutS2
K04M1_RS11560	COG2062	phosphohistidine phosphatase, SixA
K04M1_RS11575	COG1250	3-hydroxyacyl-CoA dehydrogenase
K04M1_RS11575	COG1024	Enoyl-CoA hydratase
K04M1_RS11580	COG0183	Belongs to the thiolase family
K04M1_RS11605	COG2067	long-chain fatty acid transport protein
K04M1_RS11620	COG3088	subunit of a heme lyase
K04M1_RS11620	COG4235	cytochrome complex assembly
K04M1_RS11630	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K04M1_RS11635	COG1138	Cytochrome C-type biogenesis protein
K04M1_RS11640	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
K04M1_RS11645	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K04M1_RS11650	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K04M1_RS11655	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K04M1_RS11660	COG4133	protoheme IX ABC transporter activity
K04M1_RS11670	COG0835	chemotaxis
K04M1_RS11680	COG1192	Involved in chromosome partitioning
K04M1_RS11685	COG2201	protein-glutamate methylesterase activity
K04M1_RS11690	COG0784	Response regulator, receiver
K04M1_RS11690	COG2198	Histidine kinase
K04M1_RS11690	COG0643	Histidine kinase
K04M1_RS11695	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
K04M1_RS11735	COG1987	bacterial-type flagellum assembly
K04M1_RS11790	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K04M1_RS11800	COG1677	Flagellar hook-basal body complex protein FliE
K04M1_RS11820	COG1516	flagellar protein fliS
K04M1_RS11830	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
K04M1_RS11835	COG1334	flagellar protein FlaG
K04M1_RS11840	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K04M1_RS11845	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K04M1_RS11855	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K04M1_RS11860	COG2837	iron assimilation
K04M1_RS11885	COG1393	Belongs to the ArsC family
K04M1_RS11890	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K04M1_RS11905	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
K04M1_RS11910	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K04M1_RS11945	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K04M1_RS12025	COG0210	DNA helicase
K04M1_RS12040	COG2205	protein histidine kinase activity
K04M1_RS12040	COG0784	Response regulator, receiver
K04M1_RS12050	COG1278	Cold shock
K04M1_RS12070	COG1278	Cold shock
K04M1_RS12075	COG4974	Belongs to the 'phage' integrase family
K04M1_RS12080	COG0330	HflC and HflK could
K04M1_RS12100	COG1278	Cold shock
K04M1_RS12120	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K04M1_RS12135	COG4783	chaperone-mediated protein folding
K04M1_RS12140	COG1393	Belongs to the ArsC family
K04M1_RS12160	COG2233	PERMEase
K04M1_RS12165	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K04M1_RS12170	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K04M1_RS12175	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K04M1_RS12180	COG0121	glutamine amidotransferase
K04M1_RS12185	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
K04M1_RS12190	COG1960	acyl-CoA dehydrogenase activity
K04M1_RS12225	COG0328	RNA-DNA hybrid ribonuclease activity
K04M1_RS12230	COG2226	methyltransferase
K04M1_RS12235	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K04M1_RS12240	COG0741	lytic transglycosylase activity
K04M1_RS12240	COG1388	LysM domain
K04M1_RS12250	COG3021	interspecies interaction between organisms
K04M1_RS12255	COG0347	Belongs to the P(II) protein family
K04M1_RS12270	COG0825	malonyl-CoA metabolic process
K04M1_RS12275	COG0587	DNA-directed DNA polymerase activity
K04M1_RS12285	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K04M1_RS12290	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K04M1_RS12300	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K04M1_RS12305	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
K04M1_RS12315	COG0750	zinc metalloprotease
K04M1_RS12320	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
K04M1_RS12325	COG0575	Belongs to the CDS family
K04M1_RS12330	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K04M1_RS12335	COG0233	cytoplasmic translational termination
K04M1_RS12340	COG0528	UMP kinase activity
K04M1_RS12345	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K04M1_RS12350	COG0052	Belongs to the universal ribosomal protein uS2 family
K04M1_RS12355	COG0024	Methionine aminopeptidase
K04M1_RS12360	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
K04M1_RS12370	COG0564	pseudouridine synthase activity
K04M1_RS12375	COG3098	single-species biofilm formation
K04M1_RS12410	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K04M1_RS12415	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K04M1_RS12440	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
K04M1_RS12450	COG0254	rRNA binding
K04M1_RS12455	COG1720	tRNA m6t6A37 methyltransferase activity
K04M1_RS12460	COG0442	prolyl-tRNA aminoacylation
K04M1_RS12480	COG0733	neurotransmitter:sodium symporter activity
K04M1_RS12495	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K04M1_RS12500	COG0514	ATP-dependent DNA helicase (RecQ)
K04M1_RS12530	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K04M1_RS12585	COG3621	Patatin-like phospholipase
K04M1_RS12620	COG0659	secondary active sulfate transmembrane transporter activity
K04M1_RS12625	COG0589	response to stress
K04M1_RS12630	COG0519	Catalyzes the synthesis of GMP from XMP
K04M1_RS12710	COG1477	protein flavinylation
K04M1_RS12715	COG2871	sodium ion transport
K04M1_RS12720	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K04M1_RS12725	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K04M1_RS12730	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K04M1_RS12735	COG1805	sodium ion transport
K04M1_RS12740	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K04M1_RS12745	COG0271	Belongs to the BolA IbaG family
K04M1_RS12750	COG2813	Specifically methylates the guanine in position
K04M1_RS12755	COG3056	Lipoprotein
K04M1_RS12775	COG1595	DNA-templated transcription, initiation
K04M1_RS12800	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K04M1_RS12805	COG0693	protein deglycase activity
K04M1_RS12810	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K04M1_RS12815	COG3706	GGDEF domain
K04M1_RS12820	COG2166	iron-sulfur cluster assembly
K04M1_RS12825	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
K04M1_RS12830	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
K04M1_RS12845	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K04M1_RS12845	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
K04M1_RS12855	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K04M1_RS12860	COG1074	ATP-dependent DNA helicase activity
K04M1_RS12870	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
K04M1_RS12905	COG0270	DNA (cytosine-5-)-methyltransferase activity
K04M1_RS12930	COG3141	response to X-ray
K04M1_RS12945	COG2171	N-acyltransferase activity
K04M1_RS12950	COG0584	glycerophosphoryl diester phosphodiesterase
K04M1_RS12955	COG2271	Major facilitator Superfamily
K04M1_RS12965	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K04M1_RS12970	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
K04M1_RS12975	COG1349	DNA-binding transcription factor activity
K04M1_RS12980	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
K04M1_RS12985	COG0598	Magnesium transport protein CorA
K04M1_RS13005	COG1609	Transcriptional regulator
K04M1_RS13010	COG0583	DNA-binding transcription factor activity
K04M1_RS13050	COG1022	Amp-dependent synthetase and ligase
K04M1_RS13060	COG0583	DNA-binding transcription factor activity
K04M1_RS13065	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K04M1_RS13070	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
K04M1_RS13080	COG0560	Phosphoserine phosphatase
K04M1_RS13090	COG0813	purine-nucleoside phosphorylase activity
K04M1_RS13095	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
K04M1_RS13100	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
K04M1_RS13105	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
K04M1_RS13110	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K04M1_RS13115	COG0084	hydrolase, TatD family'
K04M1_RS13145	COG3153	acetyltransferase
K04M1_RS13150	COG3154	lipid carrier protein
K04M1_RS13165	COG0826	peptidase U32
K04M1_RS13170	COG0826	peptidase U32
K04M1_RS13175	COG0534	Mate efflux family protein
K04M1_RS13190	COG1185	polyribonucleotide nucleotidyltransferase activity
K04M1_RS13195	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K04M1_RS13200	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K04M1_RS13205	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K04M1_RS13210	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K04M1_RS13215	COG0195	Participates in both transcription termination and antitermination
K04M1_RS13220	COG0779	Required for maturation of 30S ribosomal subunits
K04M1_RS13235	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K04M1_RS13245	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K04M1_RS13250	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
K04M1_RS13255	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K04M1_RS13260	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
K04M1_RS13265	COG1534	Rna-binding protein
K04M1_RS13270	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K04M1_RS13275	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K04M1_RS13280	COG2027	D-alanyl-D-alanine carboxypeptidase
K04M1_RS13290	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K04M1_RS13295	COG0739	heme binding
K04M1_RS13320	COG0628	permease
K04M1_RS13330	COG0784	Response regulator, receiver
K04M1_RS13330	COG2205	protein histidine kinase activity
K04M1_RS13335	COG0747	negative chemotaxis
K04M1_RS13345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K04M1_RS13350	COG0444	Belongs to the ABC transporter superfamily
K04M1_RS13355	COG4608	Belongs to the ABC transporter superfamily
K04M1_RS13365	COG2971	BadF BadG BcrA BcrD
K04M1_RS13380	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K04M1_RS13385	COG3842	ATPase activity
K04M1_RS13395	COG1840	ABC-type Fe3 transport system, periplasmic component
K04M1_RS13400	COG0004	ammonium transporteR
K04M1_RS13410	COG3112	Uncharacterised protein family (UPF0231)
K04M1_RS13415	COG1049	propionate catabolic process, 2-methylcitrate cycle
K04M1_RS13420	COG1752	Esterase of the alpha-beta hydrolase superfamily
K04M1_RS13425	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K04M1_RS13430	COG1643	Atp-dependent helicase
K04M1_RS13435	COG1489	DNA binding
K04M1_RS13445	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K04M1_RS13455	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K04M1_RS13460	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
K04M1_RS13465	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
K04M1_RS13470	COG1560	Kdo2-lipid A biosynthetic process
K04M1_RS13480	COG0842	Transport permease protein
K04M1_RS13485	COG1131	(ABC) transporter
K04M1_RS13490	COG0659	secondary active sulfate transmembrane transporter activity
K04M1_RS13495	COG0288	reversible hydration of carbon dioxide
K04M1_RS13510	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K04M1_RS13515	COG0508	dehydrogenase complex catalyzes the overall conversion of
K04M1_RS13520	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
K04M1_RS13525	COG2186	Transcriptional regulator
K04M1_RS13535	COG0157	Belongs to the NadC ModD family
K04M1_RS13540	COG4969	Belongs to the N-Me-Phe pilin family
K04M1_RS13545	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K04M1_RS13550	COG1459	type II secretion system
K04M1_RS13560	COG0237	dephospho-CoA kinase activity
K04M1_RS13565	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
K04M1_RS13570	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
K04M1_RS13585	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K04M1_RS13590	COG0228	four-way junction DNA binding
K04M1_RS13595	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K04M1_RS13600	COG4137	Cytochrome C assembly protein
K04M1_RS13605	COG4536	flavin adenine dinucleotide binding
K04M1_RS13610	COG1854	S-ribosylhomocysteine lyase activity
K04M1_RS13625	COG0612	Peptidase, M16
K04M1_RS13630	COG1238	metal cluster binding
K04M1_RS13640	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
K04M1_RS13645	COG5016	pyruvate
K04M1_RS13645	COG0511	ligase activity, forming carbon-carbon bonds
K04M1_RS13650	COG3630	sodium ion export across plasma membrane
K04M1_RS13710	COG0527	aspartate kinase activity
K04M1_RS13715	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K04M1_RS13720	COG2137	regulation of response to DNA damage stimulus
K04M1_RS13730	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K04M1_RS13735	COG1546	Belongs to the CinA family
K04M1_RS13740	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K04M1_RS13745	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K04M1_RS13755	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K04M1_RS13760	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
K04M1_RS13770	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
K04M1_RS13775	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
K04M1_RS13780	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
K04M1_RS13785	COG0148	phosphopyruvate hydratase activity
K04M1_RS13790	COG0504	CTP synthase activity
K04M1_RS13795	COG3956	TIGRFAM MazG family protein
K04M1_RS13800	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K04M1_RS13810	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K04M1_RS13825	COG0736	holo-[acyl-carrier-protein] synthase activity
K04M1_RS13830	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
K04M1_RS13835	COG1381	Involved in DNA repair and RecF pathway recombination
K04M1_RS13840	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K04M1_RS13850	COG0681	Belongs to the peptidase S26 family
K04M1_RS13855	COG0481	GTPase activity
K04M1_RS13860	COG3086	response to oxidative stress
K04M1_RS13875	COG1595	DNA-templated transcription, initiation
K04M1_RS13885	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
K04M1_RS13895	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
K04M1_RS13915	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K04M1_RS13920	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K04M1_RS13925	COG3079	Belongs to the UPF0149 family
K04M1_RS13935	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
K04M1_RS13945	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K04M1_RS13950	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
K04M1_RS13955	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K04M1_RS13965	COG0583	DNA-binding transcription factor activity
K04M1_RS13980	COG0668	transmembrane transport
K04M1_RS13985	COG0191	fructose-bisphosphate aldolase activity
K04M1_RS14000	COG4771	TonB-dependent receptor
K04M1_RS14005	COG0583	DNA-binding transcription factor activity
K04M1_RS14010	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K04M1_RS14020	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K04M1_RS14030	COG3091	SprT-like family
K04M1_RS14035	COG2356	endonuclease I
K04M1_RS14040	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K04M1_RS14045	COG0189	ligase activity
K04M1_RS14050	COG1678	Uncharacterized ACR, COG1678
K04M1_RS14055	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K04M1_RS14070	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K04M1_RS14075	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K04M1_RS14080	COG0762	integral membrane protein
K04M1_RS14085	COG1872	DUF167
K04M1_RS14095	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
K04M1_RS14100	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K04M1_RS14105	COG2066	Belongs to the glutaminase family
K04M1_RS14115	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K04M1_RS14125	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
K04M1_RS14170	COG0840	transmembrane signaling receptor activity
K04M1_RS14250	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
K04M1_RS14255	COG1609	Transcriptional regulator
K04M1_RS14260	COG3394	polysaccharide catabolic process
K04M1_RS14265	COG1486	melibiose metabolic process
K04M1_RS14270	COG1447	Phosphotransferase system cellobiose-specific component IIA
K04M1_RS14275	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K04M1_RS14280	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K04M1_RS14285	COG0726	polysaccharide deacetylase
K04M1_RS14295	COG1028	Short-chain dehydrogenase reductase Sdr
K04M1_RS14310	COG0795	lipopolysaccharide-transporting ATPase activity
K04M1_RS14315	COG0795	lipopolysaccharide-transporting ATPase activity
K04M1_RS14320	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K04M1_RS14325	COG2927	DNA polymerase III (CHI subunit)
K04M1_RS14330	COG0525	valine-tRNA ligase activity
K04M1_RS14340	COG0456	acetyltransferase
K04M1_RS14370	COG0540	Belongs to the ATCase OTCase family
K04M1_RS14375	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
K04M1_RS14380	COG0251	oxidation-reduction process
K04M1_RS14385	COG0204	Acyl-transferase
K04M1_RS14390	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K04M1_RS14395	COG5007	Belongs to the BolA IbaG family
K04M1_RS14405	COG2854	intermembrane phospholipid transfer
K04M1_RS14410	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K04M1_RS14415	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K04M1_RS14420	COG1127	ABC transporter
K04M1_RS14430	COG0517	IMP dehydrogenase activity
K04M1_RS14430	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
K04M1_RS14440	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
K04M1_RS14445	COG1137	ATPase activity
K04M1_RS14455	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K04M1_RS14460	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K04M1_RS14465	COG1660	Displays ATPase and GTPase activities
K04M1_RS14470	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K04M1_RS14475	COG2239	Acts as a magnesium transporter
K04M1_RS14480	COG0312	modulator of DNA gyrase
K04M1_RS14485	COG3028	Belongs to the UPF0307 family
K04M1_RS14490	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K04M1_RS14495	COG0564	pseudouridine synthase activity
K04M1_RS14505	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K04M1_RS14510	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
K04M1_RS14515	COG0312	modulator of DNA gyrase
K04M1_RS14520	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K04M1_RS14525	COG3164	Protein of unknown function
K04M1_RS14535	COG0424	maF-like protein
K04M1_RS14540	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
K04M1_RS14545	COG1792	Involved in formation and maintenance of cell shape
K04M1_RS14550	COG1077	Cell shape determining protein MreB Mrl
K04M1_RS14585	COG2165	general secretion pathway protein
K04M1_RS14595	COG1459	type II secretion system
K04M1_RS14600	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K04M1_RS14610	COG3409	Peptidoglycan-binding domain 1 protein
K04M1_RS14610	COG3267	Type II secretory pathway component ExeA
K04M1_RS14615	COG1450	Type ii and iii secretion system protein
K04M1_RS14635	COG2199	diguanylate cyclase activity
K04M1_RS14635	COG2200	EAL domain
K04M1_RS14640	COG0629	single-stranded DNA binding
K04M1_RS14655	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K04M1_RS14670	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
K04M1_RS14680	COG0527	aspartate kinase activity
K04M1_RS14685	COG1410	methionine synthase
K04M1_RS14685	COG0646	methionine synthase
K04M1_RS14750	COG0175	sulfate reduction
K04M1_RS14755	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K04M1_RS14760	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K04M1_RS14780	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K04M1_RS14785	COG0735	belongs to the Fur family
K04M1_RS14795	COG0166	Belongs to the GPI family
K04M1_RS14800	COG0432	Pfam Uncharacterised protein family UPF0047
K04M1_RS14805	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K04M1_RS14830	COG2965	DNA replication, synthesis of RNA primer
K04M1_RS14835	COG0360	Binds together with S18 to 16S ribosomal RNA
K04M1_RS14840	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K04M1_RS14845	COG0338	D12 class N6 adenine-specific DNA methyltransferase
K04M1_RS14855	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K04M1_RS14860	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K04M1_RS14890	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
K04M1_RS14900	COG0678	peroxiredoxin activity
K04M1_RS14900	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K04M1_RS14905	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K04M1_RS14915	COG0165	Argininosuccinate lyase
K04M1_RS14915	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
K04M1_RS14920	COG0137	argininosuccinate synthase activity
K04M1_RS14930	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
K04M1_RS14940	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
K04M1_RS14950	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K04M1_RS14955	COG0527	aspartate kinase activity
K04M1_RS14955	COG0460	homoserine dehydrogenase
K04M1_RS14960	COG0626	cystathionine gamma-synthase activity
K04M1_RS14965	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
K04M1_RS14970	COG0281	malic enzyme
K04M1_RS14985	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K04M1_RS14990	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K04M1_RS15010	COG2923	Belongs to the DsrF TusC family
K04M1_RS15015	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
K04M1_RS15020	COG2964	Protein conserved in bacteria
K04M1_RS15025	COG0545	Peptidyl-prolyl cis-trans isomerase
K04M1_RS15040	COG1446	asparaginase
K04M1_RS15050	COG1047	Peptidyl-prolyl cis-trans
K04M1_RS15065	COG2249	NAD(P)H dehydrogenase (quinone) activity
K04M1_RS15070	COG0488	(ABC) transporter
K04M1_RS15080	COG0429	hydrolase of the alpha beta-hydrolase fold
K04M1_RS15090	COG3954	Phosphoribulokinase
K04M1_RS15095	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K04M1_RS15115	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K04M1_RS15120	COG0512	Glutamine amidotransferase of anthranilate synthase
K04M1_RS15135	COG0180	Tryptophanyl-tRNA synthetase
K04M1_RS15140	COG0546	phosphoglycolate phosphatase activity
K04M1_RS15145	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K04M1_RS15150	COG0557	exoribonuclease II activity
K04M1_RS15155	COG1959	2 iron, 2 sulfur cluster binding
K04M1_RS15160	COG1017	nitric oxide dioxygenase activity
K04M1_RS15160	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K04M1_RS15165	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
K04M1_RS15175	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K04M1_RS15180	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
K04M1_RS15185	COG0330	HflC and HflK could
K04M1_RS15190	COG0330	HflC and HflK could
K04M1_RS15195	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K04M1_RS15205	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K04M1_RS15210	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K04M1_RS15220	COG0802	atpase or kinase
K04M1_RS15230	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K04M1_RS15295	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
K04M1_RS15300	COG1162	GTPase activity
K04M1_RS15305	COG0688	phosphatidylethanolamine metabolic process
K04M1_RS15310	COG0471	metal ion transport
K04M1_RS15320	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
K04M1_RS15325	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K04M1_RS15330	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
K04M1_RS15335	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K04M1_RS15340	COG1045	serine acetyltransferase
K04M1_RS15345	COG4942	peptidase
K04M1_RS15365	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
K04M1_RS15370	COG1053	succinate dehydrogenase
K04M1_RS15375	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K04M1_RS15380	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
K04M1_RS15385	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
K04M1_RS15400	COG1509	lysine 2,3-aminomutase activity
K04M1_RS15405	COG1285	pathogenesis
K04M1_RS15415	COG0459	protein refolding
K04M1_RS15425	COG0534	Mate efflux family protein
K04M1_RS15430	COG0205	6-phosphofructokinase activity
K04M1_RS15440	COG3678	ATP-independent chaperone mediated protein folding
K04M1_RS15445	COG0745	RESPONSE REGULATOR receiver
K04M1_RS15450	COG2205	protein histidine kinase activity
K04M1_RS15460	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
K04M1_RS15465	COG3030	protein affecting phage T7 exclusion by the F plasmid
K04M1_RS15470	COG1027	Aspartate ammonia-lyase
K04M1_RS15475	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
K04M1_RS15480	COG4232	protein-disulfide reductase activity
K04M1_RS15490	COG3263	regulation of cellular component size
K04M1_RS15500	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K04M1_RS15525	COG2814	Major facilitator Superfamily
K04M1_RS15540	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K04M1_RS15545	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K04M1_RS15550	COG0511	ligase activity, forming carbon-carbon bonds
K04M1_RS15555	COG0439	Biotin carboxylase
K04M1_RS15560	COG2264	protein methyltransferase activity
K04M1_RS15565	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K04M1_RS15570	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
K04M1_RS15580	COG0488	(ABC) transporter
K04M1_RS15635	COG1982	Orn Lys Arg decarboxylase major
K04M1_RS15640	COG0531	amino acid
K04M1_RS15650	COG3710	Transcriptional regulator
K04M1_RS15655	COG0789	Transcriptional regulator
K04M1_RS15670	COG0151	Belongs to the GarS family
K04M1_RS15685	COG1253	flavin adenine dinucleotide binding
K04M1_RS15690	COG3068	Protein conserved in bacteria
K04M1_RS15700	COG1573	uracil-dna glycosylase
K04M1_RS15705	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K04M1_RS15710	COG2816	NAD+ diphosphatase activity
K04M1_RS15715	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
K04M1_RS15720	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K04M1_RS15725	COG0085	RNA polymerase activity
K04M1_RS15730	COG0222	ribosome binding
K04M1_RS15735	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K04M1_RS15750	COG0250	Participates in transcription elongation, termination and antitermination
K04M1_RS15755	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K04M1_RS15765	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K04M1_RS15800	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
K04M1_RS15800	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
K04M1_RS15805	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K04M1_RS15815	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K04M1_RS15890	COG4206	TonB-dependent receptor
K04M1_RS15910	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K04M1_RS15915	COG0534	Mate efflux family protein
K04M1_RS15920	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
K04M1_RS15930	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K04M1_RS15940	COG2937	Belongs to the GPAT DAPAT family
K04M1_RS15945	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
K04M1_RS15950	COG3161	chorismate lyase activity
K04M1_RS15955	COG1580	Controls the rotational direction of flagella during chemotaxis
K04M1_RS15960	COG0705	Rhomboid family
K04M1_RS15965	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K04M1_RS15980	COG2177	Part of the ABC transporter FtsEX involved in
K04M1_RS15985	COG2884	Cell division ATP-binding protein ftsE
K04M1_RS15990	COG0552	protein localization to endoplasmic reticulum
K04M1_RS15995	COG0742	ribosomal rna small subunit methyltransferase
K04M1_RS16005	COG2095	MarC family integral membrane protein
K04M1_RS16050	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K04M1_RS16055	COG0640	Transcriptional regulator
K04M1_RS16060	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
K04M1_RS16065	COG1280	lysine exporter protein (LysE YggA)
K04M1_RS16070	COG2267	carboxylic ester hydrolase activity
K04M1_RS16075	COG0561	phosphatase activity
K04M1_RS16090	COG3148	PFAM DTW domain containing protein
K04M1_RS16095	COG3287	FIST C domain
K04M1_RS16095	COG2199	diguanylate cyclase activity
K04M1_RS16095	COG2200	EAL domain
K04M1_RS16100	COG1011	Hydrolase
K04M1_RS16105	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
K04M1_RS16120	COG0019	diaminopimelate decarboxylase activity
K04M1_RS16130	COG1965	Belongs to the frataxin family
K04M1_RS16135	COG3072	Adenylate cyclase
K04M1_RS16140	COG0181	hydroxymethylbilane synthase activity
K04M1_RS16145	COG1587	Uroporphyrinogen-III synthase
K04M1_RS16150	COG2959	enzyme of heme biosynthesis
K04M1_RS16155	COG3071	HemY protein
K04M1_RS16200	COG0633	Ferredoxin
K04M1_RS16205	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
K04M1_RS16220	COG3118	belongs to the thioredoxin family
K04M1_RS16225	COG0513	Belongs to the DEAD box helicase family
K04M1_RS16230	COG0248	Ppx GppA phosphatase
K04M1_RS16240	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
K04M1_RS16250	COG0514	ATP-dependent DNA helicase (RecQ)
K04M1_RS16255	COG2962	Rard protein
K04M1_RS16265	COG1280	lysine exporter protein (LysE YggA)
K04M1_RS16270	COG0405	Gamma-glutamyltransferase
K04M1_RS16280	COG0210	DNA helicase
K04M1_RS16290	COG3220	belongs to the UPF0276 family
K04M1_RS16320	COG0006	proline dipeptidase activity
K04M1_RS16320	COG0006	proline dipeptidase activity
K04M1_RS16335	COG2104	thiamine diphosphate biosynthetic process
K04M1_RS16340	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K04M1_RS16360	COG2132	Multicopper oxidase
K04M1_RS16410	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
K04M1_RS16430	COG0009	L-threonylcarbamoyladenylate synthase
K04M1_RS16435	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
K04M1_RS16440	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K04M1_RS16445	COG0551	DNA topoisomerase type I activity
K04M1_RS16450	COG2922	Belongs to the Smg family
K04M1_RS16455	COG0758	DNA mediated transformation
K04M1_RS16465	COG0242	peptide deformylase activity
K04M1_RS16470	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K04M1_RS16475	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K04M1_RS16475	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K04M1_RS16480	COG0569	domain protein
K04M1_RS16485	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K04M1_RS16495	COG1272	protein, Hemolysin III
K04M1_RS16500	COG4326	sporulation control protein
K04M1_RS16510	COG3084	Protein conserved in bacteria
K04M1_RS16520	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
K04M1_RS16525	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K04M1_RS16530	COG0204	Acyl-transferase
K04M1_RS16540	COG0606	chelatase, subunit chli
K04M1_RS16550	COG3978	acetolactate synthase activity
K04M1_RS16555	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K04M1_RS16560	COG0129	dihydroxy-acid dehydratase activity
K04M1_RS16570	COG0583	DNA-binding transcription factor activity
K04M1_RS16575	COG2814	Major facilitator Superfamily
K04M1_RS16585	COG0765	amino acid transport
K04M1_RS16595	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K04M1_RS16600	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K04M1_RS16605	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K04M1_RS16610	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K04M1_RS16615	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K04M1_RS16620	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K04M1_RS16630	COG0356	it plays a direct role in the translocation of protons across the membrane
K04M1_RS16635	COG3312	ion transport
K04M1_RS16640	COG1475	DNA binding
K04M1_RS16645	COG1192	Involved in chromosome partitioning
K04M1_RS16650	COG0357	Ribosomal RNA small subunit methyltransferase G
K04M1_RS16655	COG0445	tRNA wobble uridine modification
K04M1_RS16660	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K04M1_RS16670	COG0706	membrane insertase activity
K04M1_RS16680	COG0594	ribonuclease P activity
K04M1_RS16690	COG1126	abc transporter atp-binding protein
K04M1_RS16715	COG1444	tRNA N-acetyltransferase activity
K04M1_RS16735	COG3340	Belongs to the peptidase S51 family
K04M1_RS16740	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K04M1_RS16745	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K04M1_RS16745	COG1263	PTS System
K04M1_RS16750	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
K04M1_RS16770	COG4166	transmembrane transport
K04M1_RS16815	COG0259	pyridoxamine-phosphate oxidase activity
K04M1_RS16840	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K04M1_RS16880	COG1132	(ABC) transporter
K04M1_RS16890	COG0513	Belongs to the DEAD box helicase family
K04M1_RS16895	COG2258	MOSC domain
K04M1_RS16960	COG3634	alkyl hydroperoxide reductase activity
K04M1_RS17005	COG1846	Transcriptional regulator
K04M1_RS17010	COG1764	response to oxidative stress
K04M1_RS17045	COG0577	efflux transmembrane transporter activity
K04M1_RS17050	COG1136	(ABC) transporter
K04M1_RS17065	COG0826	peptidase U32
K04M1_RS17095	COG1653	transport
K04M1_RS17100	COG0019	diaminopimelate decarboxylase activity
K04M1_RS17105	COG4264	IucA IucC family
K04M1_RS17130	COG4772	TonB-dependent receptor
K04M1_RS17135	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
K04M1_RS17140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K04M1_RS17145	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K04M1_RS17150	COG1120	ATPase activity
K04M1_RS17155	COG0840	transmembrane signaling receptor activity
K04M1_RS17160	COG0612	Peptidase, M16
K04M1_RS17170	COG0739	heme binding
K04M1_RS17185	COG2814	Major facilitator Superfamily
K04M1_RS17195	COG1609	Transcriptional regulator
K04M1_RS17200	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K04M1_RS17220	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K04M1_RS17220	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K04M1_RS17230	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K04M1_RS17235	COG1609	Transcriptional regulator
K04M1_RS17245	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K04M1_RS17260	COG0596	Alpha beta hydrolase
K04M1_RS17285	COG1760	l-serine dehydratase
K04M1_RS17295	COG4580	involved in the transport of maltose and maltodextrins
K04M1_RS17315	COG2356	endonuclease I
K04M1_RS17335	COG1982	Orn Lys Arg decarboxylase major
K04M1_RS17340	COG0531	amino acid
K04M1_RS17350	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
K04M1_RS17355	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
K04M1_RS17360	COG1162	GTPase activity
K04M1_RS17365	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K04M1_RS17365	COG1263	PTS System
K04M1_RS17370	COG1999	signal sequence binding
K04M1_RS17385	COG2909	trisaccharide binding
K04M1_RS17390	COG0058	SHG alpha-glucan phosphorylase activity
K04M1_RS17395	COG1640	4-alpha-glucanotransferase
K04M1_RS17400	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
K04M1_RS17405	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K04M1_RS17410	COG0366	Alpha amylase catalytic
K04M1_RS17425	COG3366	ferrous iron transmembrane transporter activity
K04M1_RS17430	COG0700	Nucleoside recognition
K04M1_RS17435	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K04M1_RS17440	COG3339	Conserved Protein
K04M1_RS17445	COG1301	dicarboxylic acid transport
K04M1_RS17455	COG0583	DNA-binding transcription factor activity
K04M1_RS17475	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K04M1_RS17480	COG1596	polysaccharide export
K04M1_RS17495	COG2095	MarC family integral membrane protein
K04M1_RS17500	COG4667	esterase of the alpha-beta hydrolase superfamily
K04M1_RS17505	COG3397	chitin binding
K04M1_RS17510	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
K04M1_RS17515	COG0415	Belongs to the DNA photolyase family
K04M1_RS17525	COG1054	Belongs to the UPF0176 family
K04M1_RS17535	COG1686	Belongs to the peptidase S11 family
K04M1_RS17560	COG0583	DNA-binding transcription factor activity
K04M1_RS17565	COG4628	conserved protein (DUF2132)
K04M1_RS17585	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
K04M1_RS17590	COG0628	permease
K04M1_RS17615	COG1289	transmembrane transporter activity
K04M1_RS17635	COG2814	Major facilitator Superfamily
K04M1_RS17645	COG0454	-acetyltransferase
K04M1_RS17655	COG0745	RESPONSE REGULATOR receiver
K04M1_RS17660	COG2205	protein histidine kinase activity
K04M1_RS17675	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K04M1_RS17680	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K04M1_RS17685	COG1882	Formate acetyltransferase
K04M1_RS17720	COG1360	Flagellar Motor Protein
K04M1_RS17725	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K04M1_RS17730	COG1191	sigma factor activity
K04M1_RS17735	COG1580	Controls the rotational direction of flagella during chemotaxis
K04M1_RS17750	COG1516	flagellar protein fliS
K04M1_RS17755	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
K04M1_RS17765	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K04M1_RS17780	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K04M1_RS17790	COG1987	bacterial-type flagellum assembly
K04M1_RS17830	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K04M1_RS17890	COG0346	lactoylglutathione lyase activity
K04M1_RS17915	COG0745	RESPONSE REGULATOR receiver
K04M1_RS17940	COG3300	MHYT domain
K04M1_RS17940	COG5001	Diguanylate cyclase
K04M1_RS17945	COG0156	8-amino-7-oxononanoate synthase activity
K04M1_RS17950	COG1063	alcohol dehydrogenase
K04M1_RS17985	COG0668	transmembrane transport
K04M1_RS17995	COG1304	FMN binding
K04M1_RS18000	COG1620	l-lactate permease
K04M1_RS18005	COG0583	DNA-binding transcription factor activity
K04M1_RS18010	COG1505	serine-type exopeptidase activity
K04M1_RS18015	COG4172	Belongs to the ABC transporter superfamily
K04M1_RS18025	COG1067	ATP-dependent peptidase activity
K04M1_RS18035	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K04M1_RS18055	COG1247	-acetyltransferase
K04M1_RS18060	COG0437	4 iron, 4 sulfur cluster binding
K04M1_RS18065	COG0348	domain, Protein
K04M1_RS18085	COG1122	ATPase activity
K04M1_RS18090	COG4720	Psort location CytoplasmicMembrane, score
K04M1_RS18095	COG1566	PFAM secretion protein HlyD family protein
K04M1_RS18120	COG0813	purine-nucleoside phosphorylase activity
K04M1_RS18125	COG3272	Protein of unknown function (DUF1722)
K04M1_RS18130	COG0789	Transcriptional regulator
K04M1_RS18135	COG0415	Belongs to the DNA photolyase family
K04M1_RS18140	COG1388	LysM domain
K04M1_RS18140	COG1376	ErfK ybiS ycfS ynhG family protein
K04M1_RS18150	COG0513	Belongs to the DEAD box helicase family
K04M1_RS18155	COG1770	oligopeptidase
K04M1_RS18160	COG4771	TonB-dependent receptor
K04M1_RS18190	COG0573	inorganic phosphate transmembrane transporter activity
K04M1_RS18195	COG0581	inorganic phosphate transmembrane transporter activity
K04M1_RS18200	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K04M1_RS18215	COG2304	oxidoreductase activity
K04M1_RS18235	COG0714	Associated with various cellular activities
K04M1_RS18250	COG2197	response regulator
K04M1_RS18285	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
K04M1_RS18290	COG1120	ATPase activity
K04M1_RS18295	COG4774	siderophore transport
K04M1_RS18300	COG1132	(ABC) transporter
K04M1_RS18305	COG2205	protein histidine kinase activity
K04M1_RS18315	COG0569	domain protein
K04M1_RS18320	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K04M1_RS18325	COG0583	DNA-binding transcription factor activity
K04M1_RS18340	COG1012	belongs to the aldehyde dehydrogenase family
K04M1_RS18345	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K04M1_RS18350	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K04M1_RS18360	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
K04M1_RS18365	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K04M1_RS18395	COG2084	Dehydrogenase
K04M1_RS18400	COG0753	catalase activity
K04M1_RS18410	COG2130	NADP-dependent
K04M1_RS18415	COG1309	transcriptional regulator
K04M1_RS18420	COG3097	Belongs to the UPF0267 family
K04M1_RS18460	COG3206	protein involved in exopolysaccharide biosynthesis
K04M1_RS18460	COG0489	protein tyrosine kinase activity
K04M1_RS18475	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K04M1_RS18480	COG3842	ATPase activity
K04M1_RS18490	COG1175	transmembrane transport
K04M1_RS18495	COG3833	ABC-type maltose transport systems, permease component
K04M1_RS18525	COG2354	Protein conserved in bacteria
K04M1_RS18530	COG0418	dihydroorotase activity
K04M1_RS18540	COG0401	homolog of Blt101
K04M1_RS18545	COG3217	Mosc domain protein beta barrel domain protein
K04M1_RS18545	COG0633	Ferredoxin
K04M1_RS18545	COG3217	Mosc domain protein beta barrel domain protein
K04M1_RS18545	COG0633	Ferredoxin
K04M1_RS18555	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K04M1_RS18595	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
K04M1_RS18600	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K04M1_RS18610	COG0848	biopolymer transport protein
K04M1_RS18615	COG0811	peptide transport
K04M1_RS18620	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
K04M1_RS18630	COG3721	Heme iron utilization protein
K04M1_RS18635	COG0748	coenzyme F420 binding
K04M1_RS18645	COG0835	chemotaxis
K04M1_RS18645	COG0784	Response regulator, receiver
K04M1_RS18650	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K04M1_RS18655	COG0534	Mate efflux family protein
K04M1_RS18660	COG0444	Belongs to the ABC transporter superfamily
K04M1_RS18665	COG4608	Belongs to the ABC transporter superfamily
K04M1_RS18670	COG0747	negative chemotaxis
K04M1_RS18680	COG1349	DNA-binding transcription factor activity
K04M1_RS18685	COG2084	Dehydrogenase
K04M1_RS18690	COG3395	kinase activity
K04M1_RS18695	COG0235	Class ii aldolase
K04M1_RS18700	COG3622	Belongs to the hyi family
K04M1_RS18705	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K04M1_RS18710	COG2610	gluconate transmembrane transporter activity
K04M1_RS18730	COG0583	DNA-binding transcription factor activity
K04M1_RS18735	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K04M1_RS18745	COG4934	collagen metabolic process
K04M1_RS18755	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K04M1_RS18760	COG0789	Transcriptional regulator
K04M1_RS18765	COG0366	Alpha amylase catalytic
K04M1_RS18785	COG2249	NAD(P)H dehydrogenase (quinone) activity
K04M1_RS18790	COG0589	response to stress
K04M1_RS18795	COG0488	(ABC) transporter
K04M1_RS18800	COG1505	serine-type exopeptidase activity
K04M1_RS18810	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K04M1_RS18820	COG2067	long-chain fatty acid transport protein
K04M1_RS18830	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K04M1_RS18855	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K04M1_RS18875	COG3383	formate dehydrogenase (NAD+) activity
K04M1_RS18885	COG0842	Transport permease protein
K04M1_RS18890	COG1131	(ABC) transporter
K04M1_RS18910	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
K04M1_RS18920	COG4145	pantothenate transmembrane transporter activity
K04M1_RS18925	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K04M1_RS18930	COG0800	Aldolase
K04M1_RS18940	COG2706	6-phosphogluconolactonase activity
K04M1_RS18945	COG0251	oxidation-reduction process
K04M1_RS18955	COG1881	PFAM PEBP family protein
K04M1_RS18965	COG0798	PFAM Bile acid sodium symporter
K04M1_RS18980	COG1733	regulation of RNA biosynthetic process
K04M1_RS19005	COG4989	oxidoreductase activity
K04M1_RS19030	COG0814	amino acid
K04M1_RS19045	COG3314	Sporulation integral membrane protein YlbJ
K04M1_RS19070	COG0739	heme binding
K04M1_RS19075	COG5001	Diguanylate cyclase
K04M1_RS19080	COG0583	DNA-binding transcription factor activity
K04M1_RS19085	COG2814	Major facilitator Superfamily
K04M1_RS19105	COG0697	spore germination
K04M1_RS19120	COG0179	Fumarylacetoacetate (FAA) hydrolase
K04M1_RS19140	COG1280	lysine exporter protein (LysE YggA)
K04M1_RS19150	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K04M1_RS19155	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K04M1_RS19160	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K04M1_RS19165	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
K04M1_RS19170	COG1845	cytochrome c oxidase, subunit III
K04M1_RS19190	COG1612	heme a metabolic process
K04M1_RS19195	COG0109	protoheme IX farnesyltransferase activity
K04M1_RS19200	COG0545	Peptidyl-prolyl cis-trans isomerase
K04M1_RS19230	COG1278	Cold shock
K04M1_RS19235	COG3036	rescue of stalled ribosome
K04M1_RS19240	COG2199	diguanylate cyclase activity
K04M1_RS19255	COG1132	(ABC) transporter
K04M1_RS19260	COG1132	(ABC) transporter
K04M1_RS19265	COG1538	Outer membrane efflux protein
K04M1_RS19270	COG2205	protein histidine kinase activity
K04M1_RS19270	COG0784	Response regulator, receiver
K04M1_RS19295	COG0840	transmembrane signaling receptor activity
K04M1_RS19300	COG0783	Belongs to the Dps family
K04M1_RS19310	COG2133	pyrroloquinoline quinone binding
K04M1_RS19315	COG1454	alcohol dehydrogenase
K04M1_RS19320	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
K04M1_RS19340	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K04M1_RS19345	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K04M1_RS19350	COG3186	Phenylalanine-4-hydroxylase
K04M1_RS19375	COG3530	Putative quorum-sensing-regulated virulence factor
K04M1_RS19395	COG0513	Belongs to the DEAD box helicase family
K04M1_RS19400	COG4628	conserved protein (DUF2132)
K04M1_RS19410	COG0133	tryptophan synthase activity
K04M1_RS19420	COG1278	Cold shock
K04M1_RS19430	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
K04M1_RS19440	COG0523	cobalamin synthesis protein
K04M1_RS19445	COG0513	Belongs to the DEAD box helicase family
K04M1_RS19465	COG2200	EAL domain
K04M1_RS19470	COG1119	ATPase activity
K04M1_RS19505	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
K04M1_RS19510	COG0513	Belongs to the DEAD box helicase family
K04M1_RS19525	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K04M1_RS19535	COG1073	alpha beta
K04M1_RS19540	COG1073	alpha beta
K04M1_RS19555	COG0730	response to heat
K04M1_RS19575	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K04M1_RS19585	COG0523	cobalamin synthesis protein
K04M1_RS19590	COG2988	succinylglutamate desuccinylase activity
K04M1_RS19595	COG0739	heme binding
K04M1_RS19605	COG0523	cobalamin synthesis protein
K04M1_RS19625	COG2095	MarC family integral membrane protein
K04M1_RS19650	COG1024	Enoyl-CoA hydratase
K04M1_RS19655	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K04M1_RS19660	COG1960	acyl-CoA dehydrogenase activity
K04M1_RS19670	COG0183	Belongs to the thiolase family
K04M1_RS19685	COG1024	Enoyl-CoA hydratase
K04M1_RS19690	COG1024	Enoyl-CoA hydratase
K04M1_RS19700	COG1028	Short-chain dehydrogenase reductase Sdr
K04M1_RS19705	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K04M1_RS19710	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K04M1_RS19715	COG1845	cytochrome c oxidase, subunit III
K04M1_RS19720	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
K04M1_RS19725	COG0109	protoheme IX farnesyltransferase activity
K04M1_RS19730	COG0446	pyridine nucleotide-disulphide oxidoreductase
K04M1_RS19730	COG1902	pentaerythritol trinitrate reductase activity
K04M1_RS19745	COG1012	belongs to the aldehyde dehydrogenase family
K04M1_RS19755	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K04M1_RS19785	COG1126	abc transporter atp-binding protein
K04M1_RS19790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K04M1_RS19795	COG4215	(ABC) transporter
K04M1_RS19800	COG4160	amino acid transport
K04M1_RS19865	COG0443	Heat shock 70 kDa protein
K04M1_RS19870	COG2847	Copper chaperone PCu(A)C
K04M1_RS19935	COG0814	amino acid
K04M1_RS19945	COG0243	molybdopterin cofactor binding
K04M1_RS19975	COG1116	anion transmembrane transporter activity
K04M1_RS19975	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K04M1_RS19980	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K04M1_RS19985	COG1116	anion transmembrane transporter activity
K04M1_RS19990	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K04M1_RS19990	COG2146	nitrite reductase [NAD(P)H] activity
K04M1_RS20040	COG2815	serine threonine protein kinase
K04M1_RS20040	COG0515	serine threonine protein kinase
K04M1_RS20075	COG0631	protein serine/threonine phosphatase activity
K04M1_RS20145	COG0420	3'-5' exonuclease activity
K04M1_RS20150	COG0419	ATPase involved in DNA repair
K04M1_RS20160	COG3040	lipid binding
K04M1_RS20170	COG1288	antiporter activity
K04M1_RS20180	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
K04M1_RS20195	COG2425	protein containing a von Willebrand factor type A (vWA) domain
K04M1_RS20210	COG0583	DNA-binding transcription factor activity
K04M1_RS20215	COG0277	FAD linked oxidase domain protein
K04M1_RS20230	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K04M1_RS20270	COG2176	DNA-directed DNA polymerase activity
K04M1_RS20315	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
K04M1_RS20320	COG1328	CTP reductase activity
K04M1_RS20525	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K04M1_RS20550	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K04M1_RS20555	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K04M1_RS20565	COG2116	formate transmembrane transporter activity
K04M1_RS20585	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
K04M1_RS20625	COG3118	belongs to the thioredoxin family
K04M1_RS20630	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K04M1_RS20655	COG2271	Major facilitator Superfamily
K04M1_RS20660	COG3851	Histidine kinase
K04M1_RS20665	COG2197	response regulator
K04M1_RS20675	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K04M1_RS20680	COG0583	DNA-binding transcription factor activity
K04M1_RS20690	COG0243	molybdopterin cofactor binding
K04M1_RS20705	COG0384	phenazine biosynthesis protein PhzF
K04M1_RS20710	COG1794	racemase activity, acting on amino acids and derivatives
K04M1_RS20740	COG1328	CTP reductase activity
K04M1_RS20745	COG0602	queuosine metabolic process
K04M1_RS20750	COG0534	Mate efflux family protein
K04M1_RS20755	COG2207	Transcriptional regulator
K04M1_RS20765	COG0189	ligase activity
K04M1_RS20765	COG4067	protein conserved in archaea
K04M1_RS20775	COG3111	PFAM Bacterial OB fold (BOF) protein
K04M1_RS20785	COG0725	ABC transporter, periplasmic molybdate-binding protein
K04M1_RS20790	COG4149	molybdate abc transporter
K04M1_RS20795	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
K04M1_RS20805	COG2203	Gaf domain
K04M1_RS20805	COG3706	GGDEF domain
K04M1_RS20805	COG5001	Diguanylate cyclase
K04M1_RS20805	COG4251	negative regulation of phosphorylation
K04M1_RS20825	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
K04M1_RS20830	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
K04M1_RS20855	COG3140	Belongs to the UPF0181 family
K04M1_RS20870	COG0583	DNA-binding transcription factor activity
K04M1_RS21030	COG0023	Translation Initiation Factor
K04M1_RS21040	COG1181	Belongs to the D-alanine--D-alanine ligase family
K04M1_RS21055	COG1042	CoA-binding domain protein
K04M1_RS21055	COG0045	succinate-CoA ligase (ADP-forming) activity
K04M1_RS21055	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K04M1_RS21060	COG0583	DNA-binding transcription factor activity
K04M1_RS21080	COG5002	protein histidine kinase activity
K04M1_RS21080	COG5001	Diguanylate cyclase
K04M1_RS21080	COG3447	MASE1 domain protein
K04M1_RS21085	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
K04M1_RS21090	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
K04M1_RS21095	COG1984	allophanate hydrolase subunit 2
K04M1_RS21105	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
K04M1_RS21110	COG4181	ATPase activity
K04M1_RS21120	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K04M1_RS21125	COG3300	MHYT domain
K04M1_RS21125	COG5001	Diguanylate cyclase
K04M1_RS21160	COG4533	DNA binding
K04M1_RS21170	COG2050	protein possibly involved in aromatic compounds catabolism
K04M1_RS21185	COG2067	long-chain fatty acid transport protein
K04M1_RS21190	COG2267	carboxylic ester hydrolase activity
K04M1_RS21210	COG0861	Integral membrane protein TerC family
K04M1_RS21215	COG0737	Belongs to the 5'-nucleotidase family
K04M1_RS21220	COG3593	DNA synthesis involved in DNA repair
K04M1_RS21230	COG0583	DNA-binding transcription factor activity
K04M1_RS21235	COG2116	formate transmembrane transporter activity
K04M1_RS21240	COG2353	YceI-like domain
K04M1_RS21245	COG3038	cytochrome b561
K04M1_RS21265	COG0513	Belongs to the DEAD box helicase family
K04M1_RS21270	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
K04M1_RS21280	COG0840	transmembrane signaling receptor activity
K04M1_RS21290	COG0546	phosphoglycolate phosphatase activity
K04M1_RS21305	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K04M1_RS21310	COG2759	Belongs to the formate--tetrahydrofolate ligase family
K04M1_RS21315	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K04M1_RS21330	COG2207	Transcriptional regulator
K04M1_RS21335	COG1979	alcohol dehydrogenase
K04M1_RS21345	COG1126	abc transporter atp-binding protein
K04M1_RS21350	COG0765	amino acid transport
K04M1_RS21355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K04M1_RS21360	COG0765	amino acid transport
K04M1_RS21365	COG2199	diguanylate cyclase activity
K04M1_RS21365	COG2200	EAL domain
K04M1_RS21365	COG2203	Gaf domain
K04M1_RS21380	COG1609	Transcriptional regulator
K04M1_RS21385	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K04M1_RS21385	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K04M1_RS21390	COG1105	Belongs to the carbohydrate kinase PfkB family
K04M1_RS21395	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K04M1_RS21395	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
K04M1_RS21395	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K04M1_RS21425	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K04M1_RS21435	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K04M1_RS21440	COG0509	glycine decarboxylation via glycine cleavage system
K04M1_RS21450	COG0346	lactoylglutathione lyase activity
K04M1_RS21460	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K04M1_RS21465	COG0583	DNA-binding transcription factor activity
K04M1_RS21470	COG0697	spore germination
K04M1_RS21475	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K04M1_RS21505	COG2176	DNA-directed DNA polymerase activity
K04M1_RS21545	COG0242	peptide deformylase activity
K04M1_RS21580	COG2239	Acts as a magnesium transporter
K04M1_RS21600	COG0346	lactoylglutathione lyase activity
K04M1_RS21605	COG1902	pentaerythritol trinitrate reductase activity
K04M1_RS21615	COG2755	lipolytic protein G-D-S-L family
K04M1_RS21615	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K04M1_RS21625	COG5642	Protein of unknown function (DUF2384)
K04M1_RS21630	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
K04M1_RS21665	COG2076	Multidrug Resistance protein
K04M1_RS21685	COG2962	Rard protein
K04M1_RS21700	COG0835	chemotaxis
K04M1_RS21700	COG0784	Response regulator, receiver
K04M1_RS21710	COG2197	response regulator
K04M1_RS21720	COG3706	GGDEF domain
K04M1_RS21725	COG2197	response regulator
K04M1_RS21730	COG5001	Diguanylate cyclase
K04M1_RS21730	COG3300	MHYT domain
K04M1_RS21735	COG2205	protein histidine kinase activity
K04M1_RS21735	COG0784	Response regulator, receiver
K04M1_RS21740	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
K04M1_RS21760	COG1214	PFAM Peptidase M22, glycoprotease
K04M1_RS21760	COG0456	acetyltransferase
K04M1_RS21770	COG3069	C4-dicarboxylate transmembrane transporter activity
K04M1_RS21795	COG3111	PFAM Bacterial OB fold (BOF) protein
K04M1_RS21800	COG1597	lipid kinase activity
K04M1_RS21805	COG0583	DNA-binding transcription factor activity
K04M1_RS21810	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K04M1_RS21840	COG0714	Associated with various cellular activities
K04M1_RS21845	COG0641	radical SAM
K04M1_RS21850	COG3119	arylsulfatase activity
K04M1_RS21860	COG3119	arylsulfatase activity
K04M1_RS21865	COG0745	RESPONSE REGULATOR receiver
K04M1_RS21880	COG0784	Response regulator, receiver
K04M1_RS21880	COG2198	Histidine kinase
K04M1_RS21880	COG2205	protein histidine kinase activity
K04M1_RS21885	COG1879	ABC-type sugar transport system periplasmic component
K04M1_RS21895	COG0745	RESPONSE REGULATOR receiver
K04M1_RS21910	COG2198	Histidine kinase
K04M1_RS21910	COG0784	Response regulator, receiver
K04M1_RS21910	COG2205	protein histidine kinase activity
K04M1_RS21915	COG1879	ABC-type sugar transport system periplasmic component
K04M1_RS21920	COG1803	Methylglyoxal synthase
K04M1_RS21925	COG0210	DNA helicase
K04M1_RS21930	COG1289	transmembrane transporter activity
K04M1_RS21965	COG4771	TonB-dependent receptor
K04M1_RS21965	COG1629	transport
K04M1_RS21975	COG0789	Transcriptional regulator
K04M1_RS21980	COG4604	ABC transporter, ATP-binding protein
K04M1_RS21985	COG4605	iron ion homeostasis
K04M1_RS21990	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K04M1_RS21995	COG4607	ABC-type enterochelin transport system periplasmic component
K04M1_RS22005	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
K04M1_RS22020	COG1609	Transcriptional regulator
K04M1_RS22025	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K04M1_RS22030	COG1879	ABC-type sugar transport system periplasmic component
K04M1_RS22035	COG1172	Belongs to the binding-protein-dependent transport system permease family
K04M1_RS22040	COG1129	ABC transporter
K04M1_RS22045	COG1869	D-ribose catabolic process
K04M1_RS22050	COG5001	Diguanylate cyclase
K04M1_RS22105	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K04M1_RS22115	COG0784	Response regulator, receiver
K04M1_RS22115	COG2205	protein histidine kinase activity
K04M1_RS22130	COG0330	HflC and HflK could
K04M1_RS22145	COG0517	IMP dehydrogenase activity
K04M1_RS22145	COG4175	Glycine betaine
K04M1_RS22150	COG4176	ABC-type proline glycine betaine transport system permease component
K04M1_RS22165	COG1012	belongs to the aldehyde dehydrogenase family
K04M1_RS22170	COG1309	transcriptional regulator
K04M1_RS22180	COG1028	Short-chain dehydrogenase reductase Sdr
K04M1_RS22195	COG1024	Enoyl-CoA hydratase
K04M1_RS22200	COG1960	acyl-CoA dehydrogenase activity
K04M1_RS22210	COG0183	Belongs to the thiolase family
K04M1_RS22220	COG1960	acyl-CoA dehydrogenase activity
K04M1_RS22225	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K04M1_RS22235	COG4770	biotin carboxylase activity
K04M1_RS22250	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K04M1_RS22250	COG3264	Mechanosensitive ion channel
K04M1_RS22260	COG0110	maltose O-acetyltransferase activity
K04M1_RS22265	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K04M1_RS22270	COG1271	oxidase subunit
K04M1_RS22275	COG1294	oxidase, subunit
K04M1_RS22285	COG0384	phenazine biosynthesis protein PhzF
K04M1_RS22305	COG3527	Alpha-acetolactate decarboxylase
K04M1_RS22315	COG1028	Short-chain dehydrogenase reductase Sdr
K04M1_RS22320	COG0500	methyltransferase
K04M1_RS22350	COG1022	Amp-dependent synthetase and ligase
K04M1_RS22380	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K04M1_RS22385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K04M1_RS22385	COG1263	PTS System
K04M1_RS22390	COG1486	melibiose metabolic process
K04M1_RS22395	COG2188	Transcriptional regulator
K04M1_RS22400	COG1320	monovalent cation:proton antiporter activity
K04M1_RS22405	COG2212	antiporter activity
K04M1_RS22410	COG1863	multisubunit Na H antiporter MnhE subunit
K04M1_RS22415	COG0651	ATP synthesis coupled electron transport
K04M1_RS22420	COG1006	Multisubunit Na H antiporter MnhC subunit
K04M1_RS22425	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K04M1_RS22425	COG2111	Na H antiporter
K04M1_RS22435	COG0589	response to stress
K04M1_RS22440	COG4221	oxidoreductase activity
K04M1_RS22445	COG0583	DNA-binding transcription factor activity
K04M1_RS22455	COG2814	Major facilitator Superfamily
K04M1_RS22520	COG1522	sequence-specific DNA binding
K04M1_RS22555	COG0515	serine threonine protein kinase
K04M1_RS22580	COG3501	Rhs element vgr protein
K04M1_RS22595	COG2204	response regulator
K04M1_RS22620	COG0739	heme binding
K04M1_RS22635	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K04M1_RS22685	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
K04M1_RS22695	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
K04M1_RS22695	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
K04M1_RS22710	COG4989	oxidoreductase activity
K04M1_RS22725	COG0038	chloride channel
K04M1_RS22760	COG2897	thiosulfate sulfurtransferase activity
K04M1_RS22780	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K04M1_RS22785	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K04M1_RS22790	COG0840	transmembrane signaling receptor activity
K04M1_RS22795	COG2814	Major facilitator Superfamily
K04M1_RS22800	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K04M1_RS22815	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K04M1_RS22825	COG0840	transmembrane signaling receptor activity
K04M1_RS22845	COG2195	Cleaves the N-terminal amino acid of tripeptides
K04M1_RS22860	COG2197	response regulator
K04M1_RS22865	COG3850	Histidine kinase
K04M1_RS22870	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K04M1_RS22880	COG0243	molybdopterin cofactor binding
K04M1_RS22890	COG3005	denitrification pathway
K04M1_RS22900	COG3243	poly(R)-hydroxyalkanoic acid synthase
K04M1_RS22910	COG0183	Belongs to the thiolase family
K04M1_RS22920	COG1280	lysine exporter protein (LysE YggA)
K04M1_RS22930	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K04M1_RS22935	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K04M1_RS22990	COG1846	Transcriptional regulator
K04M1_RS22995	COG0784	Response regulator, receiver
K04M1_RS22995	COG2205	protein histidine kinase activity
K04M1_RS23000	COG1879	ABC-type sugar transport system periplasmic component
K04M1_RS23010	COG2827	Endonuclease containing a URI domain
K04M1_RS23015	COG3132	Protein of unknown function, DUF480
K04M1_RS23035	COG0784	Response regulator, receiver
K04M1_RS23035	COG5002	protein histidine kinase activity
K04M1_RS23035	COG2205	protein histidine kinase activity
K04M1_RS23060	COG0583	DNA-binding transcription factor activity
K04M1_RS23075	COG0531	amino acid
K04M1_RS23090	COG2205	protein histidine kinase activity
K04M1_RS23095	COG0745	RESPONSE REGULATOR receiver
K04M1_RS23125	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K04M1_RS23130	COG2239	Acts as a magnesium transporter
K04M1_RS23135	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
K04M1_RS23140	COG0402	S-adenosylhomocysteine deaminase activity
K04M1_RS23145	COG1418	mRNA catabolic process
K04M1_RS23160	COG2814	Major facilitator Superfamily
K04M1_RS23170	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K04M1_RS23190	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K04M1_RS23205	COG0745	RESPONSE REGULATOR receiver
K04M1_RS23210	COG2205	protein histidine kinase activity
K04M1_RS23220	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K04M1_RS23225	COG2194	sulfuric ester hydrolase activity
K04M1_RS23245	COG4667	esterase of the alpha-beta hydrolase superfamily
K04M1_RS23250	COG1741	Belongs to the pirin family
K04M1_RS23255	COG1278	Cold shock
K04M1_RS23270	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K04M1_RS23275	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K04M1_RS23275	COG0678	peroxiredoxin activity
K04M1_RS23285	COG1686	Belongs to the peptidase S11 family
K04M1_RS23295	COG0625	glutathione transferase activity
K04M1_RS23305	COG1621	beta-fructofuranosidase activity
K04M1_RS23310	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K04M1_RS23315	COG1263	PTS System
K04M1_RS23315	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K04M1_RS23335	COG1028	Short-chain dehydrogenase reductase Sdr
K04M1_RS23350	COG3746	phosphate-selective porin O and P
K04M1_RS23365	COG0300	oxidoreductase activity
K04M1_RS23370	COG0583	DNA-binding transcription factor activity
K04M1_RS23375	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K04M1_RS23375	COG2207	Transcriptional regulator
K04M1_RS23380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K04M1_RS23410	COG0513	Belongs to the DEAD box helicase family
K04M1_RS23420	COG0583	DNA-binding transcription factor activity
K04M1_RS23435	COG1902	pentaerythritol trinitrate reductase activity
K04M1_RS23440	COG1063	alcohol dehydrogenase
K04M1_RS23450	COG1028	Short-chain dehydrogenase reductase Sdr
K04M1_RS23460	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K04M1_RS23465	COG0006	proline dipeptidase activity
K04M1_RS23470	COG3608	succinylglutamate desuccinylase aspartoacylase
K04M1_RS23475	COG1522	sequence-specific DNA binding
K04M1_RS23480	COG1012	belongs to the aldehyde dehydrogenase family
K04M1_RS23485	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K04M1_RS23490	COG3122	Protein conserved in bacteria
K04M1_RS23505	COG0583	DNA-binding transcription factor activity
K04M1_RS23510	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K04M1_RS23515	COG0252	asparaginase activity
K04M1_RS23520	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
K04M1_RS23535	COG2197	response regulator
K04M1_RS23540	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K04M1_RS23565	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K04M1_RS23595	COG3842	ATPase activity
K04M1_RS23615	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K04M1_RS23645	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K04M1_RS23650	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K04M1_RS23685	COG0583	DNA-binding transcription factor activity
K04M1_RS23695	COG4948	Mandelate Racemase Muconate Lactonizing
K04M1_RS23730	COG1342	Belongs to the UPF0251 family
K04M1_RS23735	COG4176	ABC-type proline glycine betaine transport system permease component
K04M1_RS23740	COG3448	diguanylate cyclase activity
K04M1_RS23740	COG4175	Glycine betaine
K04M1_RS23745	COG3015	lipoprotein NlpE involved in copper resistance
K04M1_RS23750	COG3713	MltA-interacting MipA family protein
K04M1_RS23765	COG0583	DNA-binding transcription factor activity
K04M1_RS23790	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
K04M1_RS23800	COG1335	isochorismatase
K04M1_RS23815	COG1349	DNA-binding transcription factor activity
K04M1_RS23825	COG2070	2-Nitropropane dioxygenase
K04M1_RS23830	COG0531	amino acid
K04M1_RS23835	COG4302	ethanolamine ammonia-lyase activity
K04M1_RS23840	COG4303	Ethanolamine ammonia lyase large subunit
K04M1_RS23850	COG1309	transcriptional regulator
K04M1_RS23870	COG1280	lysine exporter protein (LysE YggA)
K04M1_RS23880	COG0459	protein refolding
K04M1_RS23885	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
K04M1_RS23895	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K04M1_RS23910	COG1304	FMN binding
K04M1_RS23935	COG4786	Flagellar basal body rod
K04M1_RS23935	COG1256	bacterial-type flagellum assembly
K04M1_RS23945	COG1706	bacterial-type flagellum-dependent cell motility
K04M1_RS23950	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
K04M1_RS23955	COG4786	Flagellar basal body rod
K04M1_RS23960	COG4787	bacterial-type flagellum-dependent cell motility
K04M1_RS23975	COG1558	bacterial-type flagellum-dependent cell motility
K04M1_RS23980	COG1815	bacterial-type flagellum-dependent cell motility
K04M1_RS24000	COG0741	lytic transglycosylase activity
K04M1_RS24005	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K04M1_RS24025	COG1760	l-serine dehydratase
K04M1_RS24040	COG0583	DNA-binding transcription factor activity
K04M1_RS24050	COG2866	Carboxypeptidase
K04M1_RS24055	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K04M1_RS24065	COG2990	Protein conserved in bacteria
K04M1_RS24090	COG3842	ATPase activity
K04M1_RS24095	COG1840	ABC-type Fe3 transport system, periplasmic component
K04M1_RS24105	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K04M1_RS24115	COG1609	Transcriptional regulator
K04M1_RS24145	COG3240	lipase activity
K04M1_RS24150	COG1309	transcriptional regulator
K04M1_RS24165	COG1136	(ABC) transporter
K04M1_RS24165	COG0577	efflux transmembrane transporter activity
K04M1_RS24170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K04M1_RS24175	COG2067	long-chain fatty acid transport protein
K04M1_RS24185	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
K04M1_RS24200	COG1011	Hydrolase
K04M1_RS24240	COG0110	maltose O-acetyltransferase activity
K04M1_RS24245	COG1765	OsmC-like protein
K04M1_RS24250	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K04M1_RS24250	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K04M1_RS24265	COG3046	protein related to deoxyribodipyrimidine photolyase
K04M1_RS24270	COG0415	Belongs to the DNA photolyase family
K04M1_RS24275	COG3706	GGDEF domain
K04M1_RS24290	COG3706	GGDEF domain
K04M1_RS24305	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K04M1_RS24325	COG3033	Beta-eliminating lyase
K04M1_RS24335	COG1271	oxidase subunit
K04M1_RS24340	COG1294	oxidase, subunit
K04M1_RS24360	COG3179	chitinase
K04M1_RS24365	COG0579	oxidoreductase
K04M1_RS24390	COG3706	GGDEF domain
K04M1_RS24420	COG0583	DNA-binding transcription factor activity
K04M1_RS24445	COG0189	ligase activity
K04M1_RS24450	COG4067	protein conserved in archaea
K04M1_RS24450	COG0189	ligase activity
K04M1_RS24460	COG1166	arginine decarboxylase activity
K04M1_RS24465	COG0010	Belongs to the arginase family
K04M1_RS24470	COG2814	Major facilitator Superfamily
K04M1_RS24475	COG1770	oligopeptidase
K04M1_RS24490	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K04M1_RS24495	COG1121	(ABC) transporter
K04M1_RS24500	COG0803	Belongs to the bacterial solute-binding protein 9 family
K04M1_RS24540	COG0848	biopolymer transport protein
K04M1_RS24545	COG0811	peptide transport
K04M1_RS24550	COG0811	peptide transport
K04M1_RS24570	COG0745	RESPONSE REGULATOR receiver
K04M1_RS24575	COG0584	glycerophosphoryl diester phosphodiesterase
K04M1_RS24585	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K04M1_RS24650	COG0312	modulator of DNA gyrase
K04M1_RS24655	COG0312	modulator of DNA gyrase
K04M1_RS24660	COG0351	phosphomethylpyrimidine kinase
K04M1_RS24665	COG1116	anion transmembrane transporter activity
K04M1_RS24670	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K04M1_RS24675	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K04M1_RS24680	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
K04M1_RS24700	COG0243	molybdopterin cofactor binding
K04M1_RS24705	COG3005	denitrification pathway
K04M1_RS24710	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K04M1_RS24715	COG1028	Short-chain dehydrogenase reductase Sdr
K04M1_RS24730	COG0456	acetyltransferase
K04M1_RS24750	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K04M1_RS24755	COG1929	Belongs to the glycerate kinase type-1 family
K04M1_RS24760	COG2610	gluconate transmembrane transporter activity
K04M1_RS24765	COG3835	regulator
K04M1_RS24825	COG3047	cAMP biosynthetic process
K04M1_RS24830	COG1357	PFAM Pentapeptide repeats (8 copies)
K04M1_RS24860	COG2375	cellular response to nickel ion
K04M1_RS24865	COG0583	DNA-binding transcription factor activity
K04M1_RS24870	COG2162	N-hydroxyarylamine O-acetyltransferase activity
K04M1_RS24875	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
K04M1_RS24890	COG2199	diguanylate cyclase activity
K04M1_RS24900	COG0561	phosphatase activity
K04M1_RS24905	COG0583	DNA-binding transcription factor activity
K04M1_RS24920	COG0564	pseudouridine synthase activity
K04M1_RS24925	COG0534	Mate efflux family protein
K04M1_RS24940	COG3123	guanosine phosphorylase activity
K04M1_RS24955	COG0596	Alpha beta hydrolase
K04M1_RS24980	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K04M1_RS24990	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K04M1_RS24995	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K04M1_RS24995	COG2169	Transcriptional regulator
K04M1_RS25005	COG2259	Doxx family
K04M1_RS25010	COG1741	Belongs to the pirin family
K04M1_RS25030	COG0363	glucosamine-6-phosphate deaminase activity
K04M1_RS25040	COG0786	glutamate:sodium symporter activity
K04M1_RS25045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K04M1_RS25050	COG1131	(ABC) transporter
K04M1_RS25060	COG0786	glutamate:sodium symporter activity
K04M1_RS25085	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K04M1_RS25095	COG3279	Response regulator of the LytR AlgR family
K04M1_RS25100	COG3275	phosphorelay sensor kinase activity
K04M1_RS25130	COG0772	Belongs to the SEDS family
K04M1_RS25155	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K04M1_RS25155	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
K04M1_RS25165	COG0444	Belongs to the ABC transporter superfamily
K04M1_RS25170	COG4608	Belongs to the ABC transporter superfamily
K04M1_RS25615	COG0358	DNA primase activity
K04M1_RS25785	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K04M1_RS25970	COG2916	Histone family protein nucleoid-structuring protein H-NS
K04M1_RS26240	COG0330	HflC and HflK could
K04M1_RS26245	COG0330	HflC and HflK could
K04M1_RS26290	COG5001	Diguanylate cyclase
K04M1_RS26290	COG2203	Gaf domain
K04M1_RS26290	COG3706	GGDEF domain
K04M1_RS26290	COG4251	negative regulation of phosphorylation
K04M1_RS26435	COG0358	DNA primase activity