locus-tag	class	description
K04M3_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K04M3_RS00010	COG0592	DNA-directed DNA polymerase activity
K04M3_RS00020	COG0187	DNA topoisomerase II activity
K04M3_RS00035	COG0071	Belongs to the small heat shock protein (HSP20) family
K04M3_RS00040	COG3977	Valine--pyruvate aminotransferase
K04M3_RS00045	COG0366	Alpha amylase catalytic
K04M3_RS00060	COG2119	membrane
K04M3_RS00070	COG0425	Belongs to the sulfur carrier protein TusA family
K04M3_RS00085	COG0604	alcohol dehydrogenase
K04M3_RS00090	COG0183	Belongs to the thiolase family
K04M3_RS00100	COG1739	Uncharacterized protein family UPF0029
K04M3_RS00105	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K04M3_RS00145	COG0583	DNA-binding transcription factor activity
K04M3_RS00150	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K04M3_RS00155	COG2960	long-chain fatty acid transporting porin activity
K04M3_RS00165	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K04M3_RS00170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K04M3_RS00230	COG4166	transmembrane transport
K04M3_RS00235	COG0601	transmembrane transport
K04M3_RS00240	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K04M3_RS00250	COG1609	Transcriptional regulator
K04M3_RS00255	COG0583	DNA-binding transcription factor activity
K04M3_RS00270	COG0129	dihydroxy-acid dehydratase activity
K04M3_RS00275	COG3265	gluconokinase activity
K04M3_RS00280	COG2610	gluconate transmembrane transporter activity
K04M3_RS00285	COG0800	Aldolase
K04M3_RS00290	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
K04M3_RS00295	COG0583	DNA-binding transcription factor activity
K04M3_RS00300	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K04M3_RS00305	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
K04M3_RS00315	COG1522	sequence-specific DNA binding
K04M3_RS00320	COG5002	protein histidine kinase activity
K04M3_RS00320	COG5001	Diguanylate cyclase
K04M3_RS00325	COG0742	ribosomal rna small subunit methyltransferase
K04M3_RS00340	COG0589	response to stress
K04M3_RS00345	COG1528	Iron-storage protein
K04M3_RS00355	COG2081	HI0933 family
K04M3_RS00385	COG1597	lipid kinase activity
K04M3_RS00415	COG0628	permease
K04M3_RS00430	COG1322	Protein conserved in bacteria
K04M3_RS00435	COG2226	methyltransferase
K04M3_RS00440	COG3165	ubiquinone biosynthetic process from chorismate
K04M3_RS00445	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K04M3_RS00455	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K04M3_RS00460	COG0805	protein transport
K04M3_RS00470	COG0084	hydrolase, TatD family'
K04M3_RS00485	COG0456	acetyltransferase
K04M3_RS00495	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K04M3_RS00495	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K04M3_RS00500	COG0218	Necessary for normal cell division and for the maintenance of normal septation
K04M3_RS00535	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K04M3_RS00545	COG2204	response regulator
K04M3_RS00550	COG3852	Histidine kinase
K04M3_RS00560	COG0174	glutamine synthetase
K04M3_RS00565	COG1217	gtp-binding protein TYPA
K04M3_RS00570	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K04M3_RS00580	COG1295	ribonuclease BN
K04M3_RS00585	COG1490	D-aminoacyl-tRNA deacylase activity
K04M3_RS00590	COG0456	acetyltransferase
K04M3_RS00600	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
K04M3_RS00605	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
K04M3_RS00610	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
K04M3_RS00615	COG3031	protein transport across the cell outer membrane
K04M3_RS00625	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K04M3_RS00630	COG1459	type II secretion system
K04M3_RS00635	COG2165	general secretion pathway protein
K04M3_RS00640	COG2165	general secretion pathway protein
K04M3_RS00645	COG2165	general secretion pathway protein
K04M3_RS00650	COG4795	General secretion pathway protein
K04M3_RS00655	COG3156	type II secretion system protein K
K04M3_RS00660	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
K04M3_RS00665	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
K04M3_RS00675	COG1218	3'(2'),5'-bisphosphate nucleotidase
K04M3_RS00680	COG0494	nUDIX hydrolase
K04M3_RS00690	COG1040	competence protein
K04M3_RS00705	COG2183	response to ionizing radiation
K04M3_RS00715	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K04M3_RS00735	COG2233	PERMEase
K04M3_RS00740	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K04M3_RS00745	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K04M3_RS00750	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K04M3_RS00755	COG1758	RNA polymerase activity
K04M3_RS00760	COG0194	GDP metabolic process
K04M3_RS00775	COG0848	biopolymer transport protein
K04M3_RS00780	COG0811	peptide transport
K04M3_RS00805	COG4174	ABC transporter (Permease)
K04M3_RS00810	COG4239	(ABC) transporter, permease
K04M3_RS00815	COG0747	negative chemotaxis
K04M3_RS00820	COG0444	Belongs to the ABC transporter superfamily
K04M3_RS00825	COG4608	Belongs to the ABC transporter superfamily
K04M3_RS00835	COG1561	YicC-like family, N-terminal region
K04M3_RS00845	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
K04M3_RS00850	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K04M3_RS00855	COG1560	Kdo2-lipid A biosynthetic process
K04M3_RS00860	COG1309	transcriptional regulator
K04M3_RS00865	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K04M3_RS00875	COG2003	Belongs to the UPF0758 family
K04M3_RS00900	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K04M3_RS00915	COG0463	Glycosyl transferase, family 2
K04M3_RS00920	COG0859	PFAM glycosyl transferase family 9
K04M3_RS00925	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K04M3_RS00930	COG3642	lipopolysaccharide core region biosynthetic process
K04M3_RS00940	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
K04M3_RS00980	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K04M3_RS00985	COG1519	Transferase
K04M3_RS00990	COG0859	PFAM glycosyl transferase family 9
K04M3_RS01000	COG1560	Kdo2-lipid A biosynthetic process
K04M3_RS01020	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K04M3_RS01070	COG0438	transferase activity, transferring glycosyl groups
K04M3_RS01080	COG0438	transferase activity, transferring glycosyl groups
K04M3_RS01080	COG0297	glycogen (starch) synthase activity
K04M3_RS01090	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K04M3_RS01095	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
K04M3_RS01100	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K04M3_RS01130	COG1215	transferase activity, transferring glycosyl groups
K04M3_RS01155	COG0149	triose-phosphate isomerase activity
K04M3_RS01185	COG1494	fructose-1,6-bisphosphatase
K04M3_RS01195	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K04M3_RS01200	COG1575	Belongs to the MenA family. Type 1 subfamily
K04M3_RS01230	COG2003	Belongs to the UPF0758 family
K04M3_RS01245	COG4565	transcriptional regulatory protein
K04M3_RS01255	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
K04M3_RS01260	COG5016	pyruvate
K04M3_RS01260	COG0511	ligase activity, forming carbon-carbon bonds
K04M3_RS01265	COG3630	sodium ion export across plasma membrane
K04M3_RS01275	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
K04M3_RS01285	COG2301	Belongs to the HpcH HpaI aldolase family
K04M3_RS01290	COG3051	citrate lyase alpha subunit
K04M3_RS01300	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
K04M3_RS01315	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K04M3_RS01320	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
K04M3_RS01330	COG1609	Transcriptional regulator
K04M3_RS01335	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K04M3_RS01345	COG0254	rRNA binding
K04M3_RS01355	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K04M3_RS01360	COG0088	Forms part of the polypeptide exit tunnel
K04M3_RS01370	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K04M3_RS01375	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K04M3_RS01380	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K04M3_RS01385	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K04M3_RS01395	COG0255	Belongs to the universal ribosomal protein uL29 family
K04M3_RS01400	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K04M3_RS01410	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K04M3_RS01415	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K04M3_RS01420	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K04M3_RS01425	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K04M3_RS01430	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K04M3_RS01445	COG1841	ribosomal large subunit assembly
K04M3_RS01450	COG0200	Binds to the 23S rRNA
K04M3_RS01455	COG0201	protein transport
K04M3_RS01460	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K04M3_RS01465	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K04M3_RS01470	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K04M3_RS01480	COG0202	RNA polymerase activity
K04M3_RS01485	COG0203	ribosomal protein L17
K04M3_RS01495	COG0545	Peptidyl-prolyl cis-trans isomerase
K04M3_RS01505	COG2153	protein acetylation
K04M3_RS01510	COG0513	Belongs to the DEAD box helicase family
K04M3_RS01525	COG1648	precorrin-2 dehydrogenase activity
K04M3_RS01525	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K04M3_RS01530	COG0175	sulfate reduction
K04M3_RS01535	COG2895	sulfate adenylyltransferase (ATP) activity
K04M3_RS01540	COG3273	potassium ion transport
K04M3_RS01540	COG0471	metal ion transport
K04M3_RS01545	COG0529	Catalyzes the synthesis of activated sulfate
K04M3_RS01565	COG4181	ATPase activity
K04M3_RS01580	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
K04M3_RS01590	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K04M3_RS01595	COG0729	surface antigen
K04M3_RS01600	COG2911	Protein conserved in bacteria
K04M3_RS01605	COG2105	PFAM AIG2 family protein
K04M3_RS01615	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
K04M3_RS01620	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
K04M3_RS01625	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K04M3_RS01630	COG0163	prenyltransferase activity
K04M3_RS01635	COG4143	(ABC) transporter
K04M3_RS01640	COG1178	ABC-type Fe3 transport system permease component
K04M3_RS01645	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
K04M3_RS01650	COG0583	DNA-binding transcription factor activity
K04M3_RS01655	COG1902	pentaerythritol trinitrate reductase activity
K04M3_RS01675	COG2358	TRAP transporter, solute receptor (TAXI family
K04M3_RS01700	COG0142	geranyltranstransferase activity
K04M3_RS01705	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K04M3_RS01715	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K04M3_RS01720	COG2966	Psort location CytoplasmicMembrane, score
K04M3_RS01730	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
K04M3_RS01735	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
K04M3_RS01740	COG2967	ApaG domain
K04M3_RS01745	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K04M3_RS01750	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
K04M3_RS01755	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K04M3_RS01760	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
K04M3_RS01765	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
K04M3_RS01785	COG0473	3-isopropylmalate dehydrogenase activity
K04M3_RS01790	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K04M3_RS01815	COG0583	DNA-binding transcription factor activity
K04M3_RS01820	COG1022	Amp-dependent synthetase and ligase
K04M3_RS01825	COG0028	Belongs to the TPP enzyme family
K04M3_RS01830	COG0440	acetolactate synthase activity
K04M3_RS01845	COG0469	pyruvate kinase activity
K04M3_RS01850	COG1349	DNA-binding transcription factor activity
K04M3_RS01855	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K04M3_RS01865	COG2376	Dihydroxyacetone kinase
K04M3_RS01870	COG1461	Dihydroxyacetone kinase
K04M3_RS01885	COG3722	fumarate hydratase activity
K04M3_RS01895	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K04M3_RS01895	COG2213	PTS system mannitol-specific
K04M3_RS01930	COG0358	DNA primase activity
K04M3_RS01935	COG1610	YqeY-like protein
K04M3_RS01940	COG0828	Belongs to the bacterial ribosomal protein bS21 family
K04M3_RS01945	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K04M3_RS01950	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K04M3_RS01955	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
K04M3_RS01960	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
K04M3_RS01965	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K04M3_RS01970	COG1968	undecaprenyl-diphosphatase activity
K04M3_RS01980	COG3267	Type II secretory pathway component ExeA
K04M3_RS01980	COG3409	Peptidoglycan-binding domain 1 protein
K04M3_RS01990	COG0405	Gamma-glutamyltransferase
K04M3_RS01995	COG4991	sh3 domain protein
K04M3_RS02000	COG0306	phosphate transporter
K04M3_RS02005	COG1392	Phosphate transport regulator
K04M3_RS02010	COG3025	triphosphatase activity
K04M3_RS02025	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
K04M3_RS02030	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
K04M3_RS02030	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
K04M3_RS02035	COG1538	Outer membrane efflux protein
K04M3_RS02040	COG0494	nUDIX hydrolase
K04M3_RS02045	COG3151	Protein conserved in bacteria
K04M3_RS02055	COG3150	esterase
K04M3_RS02065	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K04M3_RS02070	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K04M3_RS02080	COG3105	Protein conserved in bacteria
K04M3_RS02085	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
K04M3_RS02100	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K04M3_RS02105	COG0723	plastoquinol--plastocyanin reductase activity
K04M3_RS02110	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K04M3_RS02115	COG2857	Cytochrome c1
K04M3_RS02120	COG0625	glutathione transferase activity
K04M3_RS02125	COG2969	positive regulation of protein catabolic process
K04M3_RS02135	COG2823	Periplasmic or secreted lipoprotein
K04M3_RS02140	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
K04M3_RS02155	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
K04M3_RS02175	COG3116	cell division
K04M3_RS02180	COG0768	penicillin binding
K04M3_RS02185	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K04M3_RS02190	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K04M3_RS02195	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K04M3_RS02200	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K04M3_RS02205	COG0772	Belongs to the SEDS family
K04M3_RS02220	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K04M3_RS02225	COG0849	cell division
K04M3_RS02230	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K04M3_RS02235	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
K04M3_RS02245	COG0653	protein targeting
K04M3_RS02250	COG0494	nUDIX hydrolase
K04M3_RS02260	COG0505	Belongs to the CarA family
K04M3_RS02265	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K04M3_RS02280	COG0730	response to heat
K04M3_RS02285	COG0583	DNA-binding transcription factor activity
K04M3_RS02290	COG2860	membrane
K04M3_RS02305	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K04M3_RS02315	COG0493	'glutamate synthase
K04M3_RS02320	COG0069	glutamate synthase activity
K04M3_RS02320	COG0070	glutamate synthase
K04M3_RS02320	COG0067	glutamate synthase
K04M3_RS02330	COG0070	glutamate synthase
K04M3_RS02330	COG0069	glutamate synthase activity
K04M3_RS02330	COG0067	glutamate synthase
K04M3_RS02335	COG1242	4 iron, 4 sulfur cluster binding
K04M3_RS02340	COG2203	Gaf domain
K04M3_RS02340	COG4251	negative regulation of phosphorylation
K04M3_RS02340	COG5001	Diguanylate cyclase
K04M3_RS02340	COG3706	GGDEF domain
K04M3_RS02345	COG2198	Histidine kinase
K04M3_RS02345	COG0784	Response regulator, receiver
K04M3_RS02345	COG5002	protein histidine kinase activity
K04M3_RS02355	COG0745	RESPONSE REGULATOR receiver
K04M3_RS02370	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K04M3_RS02390	COG0083	homoserine kinase activity
K04M3_RS02395	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
K04M3_RS02405	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
K04M3_RS02410	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
K04M3_RS02420	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K04M3_RS02435	COG1115	amino acid carrier protein
K04M3_RS02440	COG3022	response to hydroperoxide
K04M3_RS02445	COG0513	Belongs to the DEAD box helicase family
K04M3_RS02450	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
K04M3_RS02460	COG0716	FMN binding
K04M3_RS02465	COG4974	Belongs to the 'phage' integrase family
K04M3_RS02470	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K04M3_RS02475	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K04M3_RS02490	COG2204	response regulator
K04M3_RS02500	COG0667	Aldo Keto reductase
K04M3_RS02525	COG0730	response to heat
K04M3_RS02530	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K04M3_RS02535	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
K04M3_RS02545	COG1283	sodium-dependent phosphate transmembrane transporter activity
K04M3_RS02550	COG0583	DNA-binding transcription factor activity
K04M3_RS02555	COG0640	Transcriptional regulator
K04M3_RS02560	COG0268	Binds directly to 16S ribosomal RNA
K04M3_RS02565	COG0728	peptidoglycan biosynthetic process
K04M3_RS02570	COG0196	riboflavin kinase activity
K04M3_RS02585	COG1047	Peptidyl-prolyl cis-trans
K04M3_RS02590	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K04M3_RS02600	COG3279	Response regulator of the LytR AlgR family
K04M3_RS02605	COG3275	phosphorelay sensor kinase activity
K04M3_RS02610	COG1966	Carbon starvation protein
K04M3_RS02630	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
K04M3_RS02635	COG1472	Belongs to the glycosyl hydrolase 3 family
K04M3_RS02640	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K04M3_RS02645	COG1605	Chorismate mutase
K04M3_RS02645	COG0287	Prephenate dehydrogenase
K04M3_RS02650	COG0739	heme binding
K04M3_RS02660	COG0488	(ABC) transporter
K04M3_RS02670	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
K04M3_RS02675	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
K04M3_RS02680	COG1605	Chorismate mutase
K04M3_RS02680	COG0077	Prephenate dehydratase
K04M3_RS02685	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K04M3_RS02695	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K04M3_RS02700	COG0564	pseudouridine synthase activity
K04M3_RS02710	COG0542	response to heat
K04M3_RS02775	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K04M3_RS02780	COG0826	peptidase U32
K04M3_RS02785	COG2974	May be involved in recombination
K04M3_RS02795	COG0745	RESPONSE REGULATOR receiver
K04M3_RS02800	COG5002	protein histidine kinase activity
K04M3_RS02810	COG0248	Ppx GppA phosphatase
K04M3_RS02815	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K04M3_RS02820	COG0573	inorganic phosphate transmembrane transporter activity
K04M3_RS02825	COG0581	inorganic phosphate transmembrane transporter activity
K04M3_RS02830	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K04M3_RS02835	COG0704	Plays a role in the regulation of phosphate uptake
K04M3_RS02845	COG3142	Participates in the control of copper homeostasis
K04M3_RS02850	COG0450	alkyl hydroperoxide reductase
K04M3_RS02855	COG0583	DNA-binding transcription factor activity
K04M3_RS02860	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
K04M3_RS02870	COG0517	IMP dehydrogenase activity
K04M3_RS02880	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K04M3_RS02890	COG1862	Preprotein translocase
K04M3_RS02895	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K04M3_RS02900	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K04M3_RS02915	COG0483	inositol monophosphate 1-phosphatase activity
K04M3_RS02920	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
K04M3_RS02930	COG1104	cysteine desulfurase activity
K04M3_RS02935	COG0822	iron-sulfur transferase activity
K04M3_RS02950	COG0443	Heat shock 70 kDa protein
K04M3_RS02955	COG0633	Ferredoxin
K04M3_RS02960	COG2975	iron-sulfur cluster assembly
K04M3_RS02970	COG0105	UTP biosynthetic process
K04M3_RS02985	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K04M3_RS02990	COG0124	histidyl-tRNA synthetase
K04M3_RS02995	COG2976	Protein conserved in bacteria
K04M3_RS03000	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K04M3_RS03005	COG1160	GTP binding
K04M3_RS03025	COG0516	GMP reductase activity
K04M3_RS03025	COG0517	IMP dehydrogenase activity
K04M3_RS03035	COG0582	viral genome integration into host DNA
K04M3_RS03100	COG1757	Na H antiporter
K04M3_RS03110	COG1584	GPR1 FUN34 yaaH family protein
K04M3_RS03115	COG1115	amino acid carrier protein
K04M3_RS03130	COG2873	o-acetylhomoserine
K04M3_RS03135	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K04M3_RS03155	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K04M3_RS03155	COG3153	acetyltransferase
K04M3_RS03160	COG0583	DNA-binding transcription factor activity
K04M3_RS03185	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K04M3_RS03190	COG2867	negative regulation of translational initiation
K04M3_RS03195	COG2914	Belongs to the UPF0125 (RnfH) family
K04M3_RS03200	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K04M3_RS03210	COG0497	DNA recombination
K04M3_RS03220	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K04M3_RS03225	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K04M3_RS03230	COG1301	dicarboxylic acid transport
K04M3_RS03240	COG0484	heat shock protein binding
K04M3_RS03275	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
K04M3_RS03290	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
K04M3_RS03295	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K04M3_RS03295	COG0047	phosphoribosylformylglycinamidine synthase activity
K04M3_RS03325	COG2195	Cleaves the N-terminal amino acid of tripeptides
K04M3_RS03330	COG2252	PERMEase
K04M3_RS03335	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
K04M3_RS03340	COG1073	alpha beta
K04M3_RS03350	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K04M3_RS03355	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K04M3_RS03360	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K04M3_RS03365	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K04M3_RS03365	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K04M3_RS03380	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
K04M3_RS03390	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
K04M3_RS03395	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
K04M3_RS03400	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K04M3_RS03405	COG0142	geranyltranstransferase activity
K04M3_RS03410	COG1722	exodeoxyribonuclease VII activity
K04M3_RS03415	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K04M3_RS03425	COG0301	tRNA thio-modification
K04M3_RS03425	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K04M3_RS03430	COG0583	DNA-binding transcription factor activity
K04M3_RS03440	COG2363	Small membrane protein
K04M3_RS03450	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K04M3_RS03455	COG1611	Belongs to the LOG family
K04M3_RS03470	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K04M3_RS03470	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K04M3_RS03480	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
K04M3_RS03485	COG1464	Belongs to the NlpA lipoprotein family
K04M3_RS03490	COG2011	ABC-type metal ion transport system permease component
K04M3_RS03495	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K04M3_RS03500	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
K04M3_RS03510	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K04M3_RS03510	COG1263	PTS System
K04M3_RS03515	COG0366	Alpha amylase catalytic
K04M3_RS03530	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K04M3_RS03535	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K04M3_RS03540	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K04M3_RS03545	COG0321	lipoyl(octanoyl) transferase activity
K04M3_RS03555	COG1686	Belongs to the peptidase S11 family
K04M3_RS03560	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
K04M3_RS03565	COG0772	Belongs to the SEDS family
K04M3_RS03570	COG0768	penicillin binding
K04M3_RS03575	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K04M3_RS03580	COG0799	negative regulation of ribosome biogenesis
K04M3_RS03585	COG1466	dna polymerase III delta subunit
K04M3_RS03590	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
K04M3_RS03595	COG0495	leucyl-tRNA aminoacylation
K04M3_RS03600	COG2888	peptidyl-tyrosine sulfation
K04M3_RS03605	COG0815	Transfers the fatty acyl group on membrane lipoproteins
K04M3_RS03610	COG4535	Mg2 and Co2 transporter CorC
K04M3_RS03615	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K04M3_RS03620	COG1702	phosphate starvation-inducible protein PhoH
K04M3_RS03625	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K04M3_RS03630	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K04M3_RS03740	COG0012	GTP binding
K04M3_RS03745	COG0193	aminoacyl-tRNA hydrolase activity
K04M3_RS03750	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K04M3_RS03755	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K04M3_RS03760	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
K04M3_RS03765	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
K04M3_RS03775	COG2890	protein-(glutamine-N5) methyltransferase activity
K04M3_RS03780	COG3094	Invasion gene expression up-regulator, SirB
K04M3_RS03785	COG2912	Transglutaminase-like superfamily
K04M3_RS03790	COG2877	3-deoxy-8-phosphooctulonate synthase activity
K04M3_RS03795	COG0737	Belongs to the 5'-nucleotidase family
K04M3_RS03800	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K04M3_RS03805	COG1187	pseudouridine synthase activity
K04M3_RS03810	COG2840	Smr protein MutS2
K04M3_RS03850	COG2608	mercury ion transmembrane transporter activity
K04M3_RS03850	COG2217	Heavy metal translocating P-type atpase
K04M3_RS03865	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
K04M3_RS03920	COG0784	Response regulator, receiver
K04M3_RS03920	COG0835	chemotaxis
K04M3_RS03925	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
K04M3_RS03930	COG1815	bacterial-type flagellum-dependent cell motility
K04M3_RS03935	COG1558	bacterial-type flagellum-dependent cell motility
K04M3_RS03945	COG1749	Flagellar hook protein flgE
K04M3_RS03950	COG4787	bacterial-type flagellum-dependent cell motility
K04M3_RS03960	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
K04M3_RS03965	COG1706	bacterial-type flagellum-dependent cell motility
K04M3_RS03970	COG3951	Flagellar rod assembly protein muramidase FlgJ
K04M3_RS03970	COG1705	Flagellar rod assembly protein muramidase FlgJ
K04M3_RS03980	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K04M3_RS03985	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K04M3_RS03995	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K04M3_RS04000	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K04M3_RS04005	COG2190	(PTS) system
K04M3_RS04010	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K04M3_RS04015	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K04M3_RS04025	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K04M3_RS04030	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
K04M3_RS04035	COG3115	cell septum assembly
K04M3_RS04040	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K04M3_RS04060	COG0330	HflC and HflK could
K04M3_RS04065	COG2194	sulfuric ester hydrolase activity
K04M3_RS04080	COG1192	Involved in chromosome partitioning
K04M3_RS04085	COG1215	transferase activity, transferring glycosyl groups
K04M3_RS04095	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
K04M3_RS04100	COG0457	Tetratricopeptide repeat
K04M3_RS04100	COG3118	belongs to the thioredoxin family
K04M3_RS04105	COG3118	belongs to the thioredoxin family
K04M3_RS04110	COG0300	oxidoreductase activity
K04M3_RS04115	COG1090	epimerase
K04M3_RS04145	COG0622	Phosphoesterase
K04M3_RS04165	COG3710	Transcriptional regulator
K04M3_RS04170	COG0326	Molecular chaperone. Has ATPase activity
K04M3_RS04180	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
K04M3_RS04185	COG3104	oligopeptide transport
K04M3_RS04190	COG0250	Participates in transcription elongation, termination and antitermination
K04M3_RS04195	COG0367	asparagine synthase
K04M3_RS04200	COG4651	solute:proton antiporter activity
K04M3_RS04200	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K04M3_RS04205	COG1846	Transcriptional regulator
K04M3_RS04205	COG1940	carbohydrate kinase activity
K04M3_RS04210	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K04M3_RS04220	COG2190	(PTS) system
K04M3_RS04220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K04M3_RS04220	COG1263	PTS System
K04M3_RS04225	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K04M3_RS04230	COG0735	belongs to the Fur family
K04M3_RS04240	COG0716	FMN binding
K04M3_RS04250	COG0596	Alpha beta hydrolase
K04M3_RS04255	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
K04M3_RS04260	COG0033	Phosphoglucomutase
K04M3_RS04270	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
K04M3_RS04285	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
K04M3_RS04290	COG1053	succinate dehydrogenase
K04M3_RS04295	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K04M3_RS04300	COG0567	Dehydrogenase, E1 component
K04M3_RS04305	COG0508	dehydrogenase complex catalyzes the overall conversion of
K04M3_RS04310	COG0045	succinate-CoA ligase (ADP-forming) activity
K04M3_RS04320	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K04M3_RS04325	COG1121	(ABC) transporter
K04M3_RS04330	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
K04M3_RS04335	COG4977	sequence-specific DNA binding
K04M3_RS04340	COG1918	ferrous iron import across plasma membrane
K04M3_RS04365	COG0018	arginyl-trna synthetase
K04M3_RS04370	COG3102	Protein conserved in bacteria
K04M3_RS04385	COG0788	formyltetrahydrofolate deformylase activity
K04M3_RS04390	COG1199	ATP-dependent helicase activity
K04M3_RS04395	COG1214	PFAM Peptidase M22, glycoprotease
K04M3_RS04405	COG3065	identical protein binding
K04M3_RS04410	COG2267	carboxylic ester hydrolase activity
K04M3_RS04415	COG0318	PFAM AMP-dependent synthetase and ligase
K04M3_RS04420	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
K04M3_RS04425	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
K04M3_RS04430	COG2894	cell division
K04M3_RS04435	COG0850	regulation of cytokinetic process
K04M3_RS04440	COG3100	YcgL domain-containing protein
K04M3_RS04445	COG2951	lytic endotransglycosylase activity
K04M3_RS04455	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K04M3_RS04460	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K04M3_RS04470	COG2226	methyltransferase
K04M3_RS04480	COG1028	Short-chain dehydrogenase reductase Sdr
K04M3_RS04490	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K04M3_RS04515	COG2986	histidine ammonia-lyase
K04M3_RS04520	COG1216	Glycosyl transferase, family 2
K04M3_RS04525	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K04M3_RS04540	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K04M3_RS04545	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K04M3_RS04580	COG0513	Belongs to the DEAD box helicase family
K04M3_RS04585	COG0569	domain protein
K04M3_RS04590	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K04M3_RS04605	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
K04M3_RS04610	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K04M3_RS04615	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K04M3_RS04620	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K04M3_RS04645	COG0544	peptidyl-prolyl cis-trans isomerase activity
K04M3_RS04655	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K04M3_RS04660	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K04M3_RS04665	COG0776	regulation of translation
K04M3_RS04670	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K04M3_RS04675	COG1555	photosystem II stabilization
K04M3_RS04690	COG0232	Belongs to the dGTPase family. Type 2 subfamily
K04M3_RS04695	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
K04M3_RS04700	COG0436	Aminotransferase
K04M3_RS04705	COG1169	isochorismate synthase
K04M3_RS04710	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
K04M3_RS04720	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
K04M3_RS04740	COG2855	membrane
K04M3_RS04745	COG0477	Major facilitator Superfamily
K04M3_RS04790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K04M3_RS04795	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K04M3_RS04810	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K04M3_RS04815	COG1522	sequence-specific DNA binding
K04M3_RS04825	COG1946	Acyl-CoA thioesterase
K04M3_RS04830	COG3126	Type III secretion system lipoprotein chaperone (YscW)
K04M3_RS04855	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K04M3_RS04860	COG0517	IMP dehydrogenase activity
K04M3_RS04860	COG0516	GMP reductase activity
K04M3_RS04885	COG0537	adenosine 5'-monophosphoramidase activity
K04M3_RS04910	COG3150	esterase
K04M3_RS04915	COG1252	NADH dehydrogenase
K04M3_RS04930	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K04M3_RS04940	COG4591	ABC-type transport system involved in lipoprotein release permease component
K04M3_RS04945	COG1136	(ABC) transporter
K04M3_RS04950	COG4591	ABC-type transport system involved in lipoprotein release permease component
K04M3_RS04960	COG2333	competence protein COMEC
K04M3_RS04960	COG0658	competence protein
K04M3_RS04965	COG1132	(ABC) transporter
K04M3_RS04985	COG2719	SpoVR family
K04M3_RS04990	COG2718	Belongs to the UPF0229 family
K04M3_RS04995	COG2766	serine protein kinase
K04M3_RS05005	COG3013	Belongs to the UPF0304 family
K04M3_RS05015	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K04M3_RS05025	COG1882	Formate acetyltransferase
K04M3_RS05065	COG0708	Exodeoxyribonuclease III
K04M3_RS05075	COG3923	Primosomal replication protein n
K04M3_RS05080	COG0730	response to heat
K04M3_RS05085	COG1199	ATP-dependent helicase activity
K04M3_RS05095	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K04M3_RS05100	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
K04M3_RS05105	COG1187	pseudouridine synthase activity
K04M3_RS05115	COG1278	Cold shock
K04M3_RS05120	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
K04M3_RS05125	COG0542	response to heat
K04M3_RS05130	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K04M3_RS05135	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
K04M3_RS05140	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
K04M3_RS05160	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K04M3_RS05165	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K04M3_RS05170	COG0297	glycogen (starch) synthase activity
K04M3_RS05190	COG3070	regulator of competence-specific genes
K04M3_RS05195	COG1609	Transcriptional regulator
K04M3_RS05200	COG3381	protein complex oligomerization
K04M3_RS05205	COG0745	RESPONSE REGULATOR receiver
K04M3_RS05210	COG1434	Gram-negative-bacterium-type cell wall biogenesis
K04M3_RS05215	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K04M3_RS05220	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
K04M3_RS05225	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
K04M3_RS05230	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K04M3_RS05250	COG0189	ligase activity
K04M3_RS05250	COG4067	protein conserved in archaea
K04M3_RS05260	COG0500	methyltransferase
K04M3_RS05270	COG1801	Protein of unknown function DUF72
K04M3_RS05280	COG0217	transcriptional regulatory protein
K04M3_RS05285	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
K04M3_RS05290	COG0632	four-way junction helicase activity
K04M3_RS05295	COG2255	four-way junction helicase activity
K04M3_RS05300	COG1271	oxidase subunit
K04M3_RS05305	COG1294	oxidase, subunit
K04M3_RS05310	COG4890	Cyd operon protein YbgT
K04M3_RS05320	COG0824	Thioesterase
K04M3_RS05325	COG0811	peptide transport
K04M3_RS05340	COG0823	Involved in the tonB-independent uptake of proteins
K04M3_RS05345	COG2885	chlorophyll binding
K04M3_RS05350	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
K04M3_RS05355	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
K04M3_RS05365	COG3766	membrane
K04M3_RS05375	COG0754	glutathionylspermidine amidase activity
K04M3_RS05385	COG0784	Response regulator, receiver
K04M3_RS05385	COG5002	protein histidine kinase activity
K04M3_RS05400	COG1294	oxidase, subunit
K04M3_RS05405	COG1271	oxidase subunit
K04M3_RS05425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K04M3_RS05430	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K04M3_RS05455	COG3568	Endonuclease Exonuclease Phosphatase
K04M3_RS05480	COG0583	DNA-binding transcription factor activity
K04M3_RS05490	COG0686	Belongs to the AlaDH PNT family
K04M3_RS05500	COG1674	ftsk spoiiie
K04M3_RS05510	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K04M3_RS05530	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K04M3_RS05535	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K04M3_RS05555	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
K04M3_RS05575	COG0300	oxidoreductase activity
K04M3_RS05590	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K04M3_RS05600	COG2268	Band 7 protein
K04M3_RS05610	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K04M3_RS05615	COG2915	High frequency lysogenization protein hflD homolog
K04M3_RS05630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K04M3_RS05640	COG1757	Na H antiporter
K04M3_RS05650	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K04M3_RS05660	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
K04M3_RS05660	COG0131	Imidazoleglycerol-phosphate dehydratase
K04M3_RS05665	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
K04M3_RS05670	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K04M3_RS05680	COG0140	phosphoribosyl-ATP diphosphatase activity
K04M3_RS05680	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K04M3_RS05685	COG3012	SEC-C Motif Domain Protein
K04M3_RS05690	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
K04M3_RS05695	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K04M3_RS05700	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K04M3_RS05705	COG0215	cysteine-tRNA ligase activity
K04M3_RS05710	COG1435	thymidine kinase activity
K04M3_RS05740	COG2116	formate transmembrane transporter activity
K04M3_RS05750	COG0390	transport system, permease component
K04M3_RS05755	COG4459	periplasmic nitrate reductase
K04M3_RS05760	COG3005	denitrification pathway
K04M3_RS05765	COG0243	molybdopterin cofactor binding
K04M3_RS05780	COG1227	inorganic diphosphatase activity
K04M3_RS05790	COG4172	Belongs to the ABC transporter superfamily
K04M3_RS05800	COG4171	peptide transport system, permease
K04M3_RS05815	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
K04M3_RS05820	COG1842	Phage shock protein A
K04M3_RS05830	COG1983	PspC domain protein
K04M3_RS05850	COG2818	Glycosylase
K04M3_RS05855	COG5380	lipid catabolic process
K04M3_RS05860	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
K04M3_RS05865	COG0626	cystathionine gamma-synthase activity
K04M3_RS05875	COG0733	neurotransmitter:sodium symporter activity
K04M3_RS05880	COG0564	pseudouridine synthase activity
K04M3_RS05890	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K04M3_RS05895	COG1151	hydroxylamine reductase activity
K04M3_RS05900	COG3604	Transcriptional regulator
K04M3_RS05910	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K04M3_RS05915	COG4136	ATPase activity
K04M3_RS05920	COG4135	transport system, permease component
K04M3_RS05925	COG4134	Bacterial extracellular solute-binding protein
K04M3_RS05935	COG3313	Fe-S protein
K04M3_RS05955	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
K04M3_RS05975	COG1061	Type III restriction enzyme res subunit
K04M3_RS05980	COG1187	pseudouridine synthase activity
K04M3_RS05990	COG2814	Major facilitator Superfamily
K04M3_RS06000	COG0702	epimerase
K04M3_RS06005	COG0534	Mate efflux family protein
K04M3_RS06025	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K04M3_RS06040	COG1960	acyl-CoA dehydrogenase activity
K04M3_RS06045	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K04M3_RS06050	COG2985	domain, Protein
K04M3_RS06050	COG3273	potassium ion transport
K04M3_RS06055	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K04M3_RS06065	COG1737	Transcriptional regulator
K04M3_RS06070	COG0076	glutamate decarboxylase activity
K04M3_RS06080	COG2431	L-lysine efflux transmembrane transporter activity
K04M3_RS06100	COG3070	regulator of competence-specific genes
K04M3_RS06115	COG4191	Histidine kinase
K04M3_RS06115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K04M3_RS06125	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
K04M3_RS06135	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
K04M3_RS06140	COG4988	ABC transporter
K04M3_RS06145	COG0492	ferredoxin-NADP+ reductase activity
K04M3_RS06170	COG0471	metal ion transport
K04M3_RS06175	COG2949	membrane
K04M3_RS06180	COG0281	malic enzyme
K04M3_RS06185	COG1643	Atp-dependent helicase
K04M3_RS06200	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K04M3_RS06235	COG0277	FAD linked oxidase domain protein
K04M3_RS06235	COG0247	lactate metabolic process
K04M3_RS06250	COG2986	histidine ammonia-lyase
K04M3_RS06255	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
K04M3_RS06260	COG0010	Belongs to the arginase family
K04M3_RS06265	COG1228	amidohydrolase
K04M3_RS06270	COG2188	Transcriptional regulator
K04M3_RS06285	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K04M3_RS06295	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K04M3_RS06305	COG0393	Putative heavy-metal-binding
K04M3_RS06340	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K04M3_RS06345	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K04M3_RS06345	COG0072	phenylalanine-tRNA ligase activity
K04M3_RS06355	COG0776	regulation of translation
K04M3_RS06365	COG0500	methyltransferase
K04M3_RS06370	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
K04M3_RS06375	COG0295	cytidine deaminase activity
K04M3_RS06380	COG1346	cytolysis
K04M3_RS06385	COG1380	Effector of murein hydrolase LrgA
K04M3_RS06390	COG2925	Exonuclease
K04M3_RS06445	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K04M3_RS06470	COG1484	DNA-dependent DNA replication
K04M3_RS06615	COG1823	symporter activity
K04M3_RS06620	COG0702	epimerase
K04M3_RS06625	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
K04M3_RS06630	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
K04M3_RS06650	COG2988	succinylglutamate desuccinylase activity
K04M3_RS06655	COG4139	cobalamin transport
K04M3_RS06660	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
K04M3_RS06680	COG0583	DNA-binding transcription factor activity
K04M3_RS06690	COG1451	nucleotide metabolic process
K04M3_RS06695	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
K04M3_RS06725	COG3938	Belongs to the proline racemase family
K04M3_RS06740	COG2423	ornithine cyclodeaminase activity
K04M3_RS06745	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K04M3_RS06750	COG3842	ATPase activity
K04M3_RS06755	COG1176	ABC-type spermidine putrescine transport system, permease component I
K04M3_RS06760	COG1177	transmembrane transport
K04M3_RS06770	COG3291	Pkd domain containing protein
K04M3_RS06790	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K04M3_RS06795	COG0601	transmembrane transport
K04M3_RS06805	COG2195	Cleaves the N-terminal amino acid of tripeptides
K04M3_RS06815	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
K04M3_RS06825	COG0625	glutathione transferase activity
K04M3_RS06875	COG3755	Protein conserved in bacteria
K04M3_RS06900	COG1742	UPF0060 membrane protein
K04M3_RS06915	COG1757	Na H antiporter
K04M3_RS06920	COG0174	glutamine synthetase
K04M3_RS06930	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
K04M3_RS06935	COG1917	Cupin 2, conserved barrel domain protein
K04M3_RS06935	COG1396	sequence-specific DNA binding
K04M3_RS06940	COG1012	belongs to the aldehyde dehydrogenase family
K04M3_RS06945	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K04M3_RS06955	COG2957	Belongs to the agmatine deiminase family
K04M3_RS06960	COG1012	belongs to the aldehyde dehydrogenase family
K04M3_RS06965	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K04M3_RS06985	COG2315	Protein conserved in bacteria
K04M3_RS07050	COG1742	UPF0060 membrane protein
K04M3_RS07065	COG1757	Na H antiporter
K04M3_RS07070	COG0174	glutamine synthetase
K04M3_RS07080	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
K04M3_RS07085	COG1396	sequence-specific DNA binding
K04M3_RS07085	COG1917	Cupin 2, conserved barrel domain protein
K04M3_RS07090	COG1012	belongs to the aldehyde dehydrogenase family
K04M3_RS07095	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K04M3_RS07105	COG2957	Belongs to the agmatine deiminase family
K04M3_RS07110	COG1012	belongs to the aldehyde dehydrogenase family
K04M3_RS07115	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K04M3_RS07120	COG2200	EAL domain
K04M3_RS07130	COG1846	Transcriptional regulator
K04M3_RS07135	COG2315	Protein conserved in bacteria
K04M3_RS07175	COG3063	Type IV pilus biogenesis stability protein PilW
K04M3_RS07180	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
K04M3_RS07195	COG1560	Kdo2-lipid A biosynthetic process
K04M3_RS07200	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
K04M3_RS07205	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K04M3_RS07330	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
K04M3_RS07335	COG1280	lysine exporter protein (LysE YggA)
K04M3_RS07345	COG1115	amino acid carrier protein
K04M3_RS07370	COG1368	sulfuric ester hydrolase activity
K04M3_RS07375	COG2113	Glycine betaine
K04M3_RS07380	COG4176	ABC-type proline glycine betaine transport system permease component
K04M3_RS07385	COG4175	Glycine betaine
K04M3_RS07400	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K04M3_RS07405	COG0456	acetyltransferase
K04M3_RS07410	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K04M3_RS07415	COG0662	Cupin 2, conserved barrel domain protein
K04M3_RS07420	COG0527	aspartate kinase activity
K04M3_RS07425	COG3119	arylsulfatase activity
K04M3_RS07440	COG0641	radical SAM
K04M3_RS07455	COG3119	arylsulfatase activity
K04M3_RS07480	COG1538	Outer membrane efflux protein
K04M3_RS07495	COG1349	DNA-binding transcription factor activity
K04M3_RS07500	COG0673	inositol 2-dehydrogenase activity
K04M3_RS07505	COG4702	Belongs to the UPF0303 family
K04M3_RS07530	COG0471	metal ion transport
K04M3_RS07545	COG5001	Diguanylate cyclase
K04M3_RS07545	COG3300	MHYT domain
K04M3_RS07560	COG1328	CTP reductase activity
K04M3_RS07565	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K04M3_RS07575	COG0861	Integral membrane protein TerC family
K04M3_RS07585	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
K04M3_RS07595	COG0814	amino acid
K04M3_RS07610	COG1120	ATPase activity
K04M3_RS07615	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K04M3_RS07625	COG4774	siderophore transport
K04M3_RS07635	COG1132	(ABC) transporter
K04M3_RS07640	COG1132	(ABC) transporter
K04M3_RS07655	COG0583	DNA-binding transcription factor activity
K04M3_RS07680	COG0443	Heat shock 70 kDa protein
K04M3_RS07685	COG0443	Heat shock 70 kDa protein
K04M3_RS07730	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
K04M3_RS07735	COG1643	Atp-dependent helicase
K04M3_RS07750	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K04M3_RS07760	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K04M3_RS07765	COG1215	transferase activity, transferring glycosyl groups
K04M3_RS07770	COG0438	transferase activity, transferring glycosyl groups
K04M3_RS07800	COG0438	transferase activity, transferring glycosyl groups
K04M3_RS07805	COG0438	transferase activity, transferring glycosyl groups
K04M3_RS07810	COG2204	response regulator
K04M3_RS07845	COG1793	dna ligase
K04M3_RS07855	COG0534	Mate efflux family protein
K04M3_RS07860	COG0307	riboflavin synthase, alpha
K04M3_RS07870	COG3001	Fructosamine kinase
K04M3_RS07880	COG3706	GGDEF domain
K04M3_RS07890	COG0791	NLP P60 protein
K04M3_RS07925	COG3148	PFAM DTW domain containing protein
K04M3_RS07930	COG1940	carbohydrate kinase activity
K04M3_RS07945	COG0746	molybdenum cofactor guanylyltransferase activity
K04M3_RS07950	COG3842	ATPase activity
K04M3_RS07965	COG2204	response regulator
K04M3_RS07970	COG4191	Histidine kinase
K04M3_RS07975	COG0488	(ABC) transporter
K04M3_RS07980	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K04M3_RS08000	COG3381	protein complex oligomerization
K04M3_RS08010	COG3383	formate dehydrogenase (NAD+) activity
K04M3_RS08010	COG0243	molybdopterin cofactor binding
K04M3_RS08015	COG0437	4 iron, 4 sulfur cluster binding
K04M3_RS08040	COG0004	ammonium transporteR
K04M3_RS08045	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K04M3_RS08050	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K04M3_RS08060	COG1177	transmembrane transport
K04M3_RS08070	COG3842	ATPase activity
K04M3_RS08095	COG0589	response to stress
K04M3_RS08100	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K04M3_RS08115	COG2217	Heavy metal translocating P-type atpase
K04M3_RS08125	COG2010	Cytochrome c
K04M3_RS08140	COG3278	Belongs to the heme-copper respiratory oxidase family
K04M3_RS08155	COG0784	Response regulator, receiver
K04M3_RS08155	COG2205	protein histidine kinase activity
K04M3_RS08175	COG3120	sequence-specific DNA binding
K04M3_RS08180	COG1067	ATP-dependent peptidase activity
K04M3_RS08185	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K04M3_RS08200	COG0488	(ABC) transporter
K04M3_RS08210	COG0116	Belongs to the methyltransferase superfamily
K04M3_RS08210	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K04M3_RS08220	COG0167	dihydroorotate dehydrogenase activity
K04M3_RS08225	COG2902	Dehydrogenase
K04M3_RS08235	COG0308	aminopeptidase N
K04M3_RS08250	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
K04M3_RS08255	COG1956	GAF domain-containing protein
K04M3_RS08260	COG1132	(ABC) transporter
K04M3_RS08265	COG2995	paraquat-inducible protein a
K04M3_RS08270	COG3008	intermembrane lipid transfer
K04M3_RS08295	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K04M3_RS08300	COG1666	GTP binding
K04M3_RS08315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K04M3_RS08320	COG4597	amino acid ABC transporter
K04M3_RS08325	COG0765	amino acid transport
K04M3_RS08330	COG1126	abc transporter atp-binding protein
K04M3_RS08335	COG0670	Belongs to the BI1 family
K04M3_RS08350	COG2920	part of a sulfur-relay system
K04M3_RS08355	COG1254	Belongs to the acylphosphatase family
K04M3_RS08360	COG0840	transmembrane signaling receptor activity
K04M3_RS08380	COG2885	chlorophyll binding
K04M3_RS08405	COG2203	Gaf domain
K04M3_RS08405	COG2199	diguanylate cyclase activity
K04M3_RS08410	COG1414	Transcriptional regulator
K04M3_RS08420	COG0656	L-ascorbic acid biosynthetic process
K04M3_RS08425	COG0583	DNA-binding transcription factor activity
K04M3_RS08435	COG0583	DNA-binding transcription factor activity
K04M3_RS08440	COG2814	Major facilitator Superfamily
K04M3_RS08460	COG1335	isochorismatase
K04M3_RS08465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K04M3_RS08480	COG0646	methionine synthase
K04M3_RS08480	COG1410	methionine synthase
K04M3_RS08485	COG1126	abc transporter atp-binding protein
K04M3_RS08490	COG0765	amino acid transport
K04M3_RS08495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K04M3_RS08510	COG0583	DNA-binding transcription factor activity
K04M3_RS08525	COG0583	DNA-binding transcription factor activity
K04M3_RS08535	COG0583	DNA-binding transcription factor activity
K04M3_RS08550	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
K04M3_RS08555	COG0602	queuosine metabolic process
K04M3_RS08560	COG0561	phosphatase activity
K04M3_RS08585	COG2828	Protein conserved in bacteria
K04M3_RS08595	COG0372	Belongs to the citrate synthase family
K04M3_RS08600	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
K04M3_RS08635	COG0730	response to heat
K04M3_RS08640	COG2358	TRAP transporter, solute receptor (TAXI family
K04M3_RS08655	COG0457	Tetratricopeptide repeat
K04M3_RS08725	COG4790	Type iii secretion
K04M3_RS08730	COG4794	Type iii secretion
K04M3_RS08735	COG4791	protein targeting
K04M3_RS08740	COG4792	protein secretion
K04M3_RS08745	COG2207	Transcriptional regulator
K04M3_RS08775	COG3177	Filamentation induced by cAMP protein fic
K04M3_RS08795	COG4669	(LipO)protein
K04M3_RS08865	COG1012	belongs to the aldehyde dehydrogenase family
K04M3_RS08870	COG3284	Transcriptional regulator
K04M3_RS08885	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
K04M3_RS08890	COG0363	glucosamine-6-phosphate deaminase activity
K04M3_RS08895	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K04M3_RS08900	COG2207	Transcriptional regulator
K04M3_RS08910	COG4565	transcriptional regulatory protein
K04M3_RS08915	COG3290	protein histidine kinase activity
K04M3_RS08930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K04M3_RS08945	COG0583	DNA-binding transcription factor activity
K04M3_RS08960	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
K04M3_RS08970	COG2985	domain, Protein
K04M3_RS08995	COG2272	Belongs to the type-B carboxylesterase lipase family
K04M3_RS09005	COG0729	surface antigen
K04M3_RS09015	COG1280	lysine exporter protein (LysE YggA)
K04M3_RS09020	COG1280	lysine exporter protein (LysE YggA)
K04M3_RS09025	COG5507	3-demethylubiquinone-9 3-methyltransferase
K04M3_RS09045	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K04M3_RS09055	COG0110	maltose O-acetyltransferase activity
K04M3_RS09105	COG2801	Transposase and inactivated derivatives
K04M3_RS09135	COG1683	Conserved Protein
K04M3_RS09220	COG2801	Transposase and inactivated derivatives
K04M3_RS09255	COG1403	HNH endonuclease
K04M3_RS09345	COG4974	Belongs to the 'phage' integrase family
K04M3_RS09355	COG3706	GGDEF domain
K04M3_RS09370	COG2985	domain, Protein
K04M3_RS09375	COG0076	glutamate decarboxylase activity
K04M3_RS09380	COG2963	transposase activity
K04M3_RS09385	COG0598	Magnesium transport protein CorA
K04M3_RS09395	COG0387	Pfam Sodium calcium exchanger
K04M3_RS09400	COG0387	Pfam Sodium calcium exchanger
K04M3_RS09415	COG1289	transmembrane transporter activity
K04M3_RS09430	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
K04M3_RS09440	COG2985	domain, Protein
K04M3_RS09445	COG0025	NhaP-type Na H and K H
K04M3_RS09470	COG3302	dmso reductase anchor subunit
K04M3_RS09475	COG0437	4 iron, 4 sulfur cluster binding
K04M3_RS09480	COG0243	molybdopterin cofactor binding
K04M3_RS09490	COG2221	Nitrite and sulphite reductase 4Fe-4S
K04M3_RS09490	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K04M3_RS09495	COG0784	Response regulator, receiver
K04M3_RS09495	COG2205	protein histidine kinase activity
K04M3_RS09570	COG3477	response to acidic pH
K04M3_RS09575	COG2200	EAL domain
K04M3_RS09575	COG2199	diguanylate cyclase activity
K04M3_RS09575	COG3287	FIST C domain
K04M3_RS09580	COG2197	response regulator
K04M3_RS09650	COG1472	Belongs to the glycosyl hydrolase 3 family
K04M3_RS09660	COG2205	protein histidine kinase activity
K04M3_RS09660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K04M3_RS09665	COG2197	response regulator
K04M3_RS09740	COG1335	isochorismatase
K04M3_RS09850	COG4628	conserved protein (DUF2132)
K04M3_RS09900	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K04M3_RS09910	COG3768	UPF0283 membrane protein
K04M3_RS09915	COG3106	COG3106 Predicted ATPase
K04M3_RS09930	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K04M3_RS09935	COG2205	protein histidine kinase activity
K04M3_RS09935	COG0784	Response regulator, receiver
K04M3_RS09945	COG0494	nUDIX hydrolase
K04M3_RS09950	COG0814	amino acid
K04M3_RS09955	COG1760	l-serine dehydratase
K04M3_RS09960	COG2200	EAL domain
K04M3_RS09970	COG0720	synthase
K04M3_RS09975	COG0840	transmembrane signaling receptor activity
K04M3_RS09980	COG0017	Asparaginyl-tRNA synthetase
K04M3_RS09990	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K04M3_RS10005	COG1448	Aminotransferase
K04M3_RS10025	COG0840	transmembrane signaling receptor activity
K04M3_RS10030	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K04M3_RS10060	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
K04M3_RS10075	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K04M3_RS10080	COG3108	Peptidase M15
K04M3_RS10085	COG2989	Protein conserved in bacteria
K04M3_RS10110	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K04M3_RS10120	COG4235	cytochrome complex assembly
K04M3_RS10120	COG3088	subunit of a heme lyase
K04M3_RS10130	COG1138	Cytochrome C-type biogenesis protein
K04M3_RS10135	COG3301	Polysulphide reductase, NrfD
K04M3_RS10140	COG0437	4 iron, 4 sulfur cluster binding
K04M3_RS10150	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
K04M3_RS10170	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K04M3_RS10175	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K04M3_RS10205	COG0019	diaminopimelate decarboxylase activity
K04M3_RS10250	COG0322	excinuclease ABC activity
K04M3_RS10255	COG2197	response regulator
K04M3_RS10260	COG0417	DNA replication proofreading
K04M3_RS10280	COG1187	pseudouridine synthase activity
K04M3_RS10290	COG0009	L-threonylcarbamoyladenylate synthase
K04M3_RS10295	COG0613	PHP domain protein
K04M3_RS10305	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K04M3_RS10310	COG0512	Glutamine amidotransferase of anthranilate synthase
K04M3_RS10320	COG0134	indole-3-glycerol-phosphate synthase activity
K04M3_RS10320	COG0135	phosphoribosylanthranilate isomerase activity
K04M3_RS10330	COG0159	tryptophan synthase activity
K04M3_RS10335	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K04M3_RS10340	COG0318	PFAM AMP-dependent synthetase and ligase
K04M3_RS10350	COG1301	dicarboxylic acid transport
K04M3_RS10370	COG2917	probably involved in intracellular septation
K04M3_RS10380	COG2350	Protein conserved in bacteria
K04M3_RS10390	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
K04M3_RS10395	COG0583	DNA-binding transcription factor activity
K04M3_RS10410	COG5001	Diguanylate cyclase
K04M3_RS10415	COG1032	radical SAM domain protein
K04M3_RS10435	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
K04M3_RS10440	COG0463	Glycosyl transferase, family 2
K04M3_RS10445	COG0745	RESPONSE REGULATOR receiver
K04M3_RS10450	COG5002	protein histidine kinase activity
K04M3_RS10450	COG3850	Histidine kinase
K04M3_RS10500	COG0577	efflux transmembrane transporter activity
K04M3_RS10500	COG1136	(ABC) transporter
K04M3_RS10505	COG1136	(ABC) transporter
K04M3_RS10505	COG0577	efflux transmembrane transporter activity
K04M3_RS10510	COG0577	efflux transmembrane transporter activity
K04M3_RS10510	COG1136	(ABC) transporter
K04M3_RS10520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K04M3_RS10545	COG3118	belongs to the thioredoxin family
K04M3_RS10550	COG4232	protein-disulfide reductase activity
K04M3_RS10585	COG2863	cytochrome
K04M3_RS10590	COG3258	Cytochrome c
K04M3_RS10595	COG2995	paraquat-inducible protein a
K04M3_RS10600	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K04M3_RS10600	COG3008	intermembrane lipid transfer
K04M3_RS10620	COG4166	transmembrane transport
K04M3_RS10630	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
K04M3_RS10635	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
K04M3_RS10645	COG0539	negative regulation of cytoplasmic translation
K04M3_RS10650	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K04M3_RS10655	COG0616	signal peptide processing
K04M3_RS10660	COG1028	Short-chain dehydrogenase reductase Sdr
K04M3_RS10675	COG0587	DNA-directed DNA polymerase activity
K04M3_RS10680	COG0835	chemotaxis
K04M3_RS10680	COG0784	Response regulator, receiver
K04M3_RS10685	COG1940	carbohydrate kinase activity
K04M3_RS10690	COG0469	pyruvate kinase activity
K04M3_RS10695	COG4667	esterase of the alpha-beta hydrolase superfamily
K04M3_RS10710	COG0733	neurotransmitter:sodium symporter activity
K04M3_RS10725	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K04M3_RS10725	COG1263	PTS System
K04M3_RS10730	COG0084	hydrolase, TatD family'
K04M3_RS10735	COG0470	DNA polymerase III
K04M3_RS10740	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K04M3_RS10745	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K04M3_RS10775	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K04M3_RS10780	COG0416	fatty acid biosynthetic process
K04M3_RS10790	COG1399	metal-binding, possibly nucleic acid-binding protein
K04M3_RS10795	COG0424	maF-like protein
K04M3_RS10800	COG0564	pseudouridine synthase activity
K04M3_RS10810	COG1530	ribonuclease E activity
K04M3_RS10820	COG0659	secondary active sulfate transmembrane transporter activity
K04M3_RS10825	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K04M3_RS10830	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
K04M3_RS10840	COG0572	uridine kinase
K04M3_RS10850	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K04M3_RS10850	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K04M3_RS10870	COG2186	Transcriptional regulator
K04M3_RS10875	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K04M3_RS10880	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
K04M3_RS10885	COG3318	Belongs to the UPF0149 family
K04M3_RS10885	COG3012	SEC-C Motif Domain Protein
K04M3_RS10890	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K04M3_RS10895	COG3706	GGDEF domain
K04M3_RS10900	COG0366	Alpha amylase catalytic
K04M3_RS10905	COG1122	ATPase activity
K04M3_RS10910	COG4120	Belongs to the binding-protein-dependent transport system permease family
K04M3_RS10920	COG3092	negative regulation of chromosome organization
K04M3_RS10925	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K04M3_RS10930	COG0857	belongs to the CobB CobQ family
K04M3_RS10930	COG0280	phosphate acetyltransferase
K04M3_RS10940	COG0435	Glutathione S-transferase
K04M3_RS10950	COG0444	Belongs to the ABC transporter superfamily
K04M3_RS10955	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K04M3_RS10960	COG0601	transmembrane transport
K04M3_RS10970	COG0314	molybdopterin synthase activity
K04M3_RS10975	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
K04M3_RS10980	COG0315	cyclic pyranopterin monophosphate synthase activity
K04M3_RS10985	COG0521	Mo-molybdopterin cofactor biosynthetic process
K04M3_RS10990	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K04M3_RS10995	COG0391	Required for morphogenesis under gluconeogenic growth conditions
K04M3_RS11000	COG2198	Histidine kinase
K04M3_RS11005	COG2204	response regulator
K04M3_RS11010	COG0556	nucleotide-excision repair
K04M3_RS11020	COG1882	Formate acetyltransferase
K04M3_RS11025	COG4657	Part of a membrane complex involved in electron transport
K04M3_RS11030	COG2878	Part of a membrane complex involved in electron transport
K04M3_RS11035	COG4656	Part of a membrane complex involved in electron transport
K04M3_RS11040	COG4658	electron transport chain
K04M3_RS11045	COG4659	FMN binding
K04M3_RS11050	COG4660	Part of a membrane complex involved in electron transport
K04M3_RS11055	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K04M3_RS11060	COG0346	lactoylglutathione lyase activity
K04M3_RS11070	COG2885	chlorophyll binding
K04M3_RS11075	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K04M3_RS11080	COG2056	Na+-H+ antiporter family
K04M3_RS11100	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
K04M3_RS11125	COG1454	alcohol dehydrogenase
K04M3_RS11125	COG1012	belongs to the aldehyde dehydrogenase family
K04M3_RS11130	COG2095	MarC family integral membrane protein
K04M3_RS11135	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K04M3_RS11140	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K04M3_RS11145	COG1757	Na H antiporter
K04M3_RS11160	COG3081	Nucleoid-associated protein
K04M3_RS11165	COG3082	Protein of unknown function (DUF1414)
K04M3_RS11180	COG0123	including yeast histone deacetylase and acetoin utilization protein
K04M3_RS11195	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K04M3_RS11200	COG0778	Nitroreductase
K04M3_RS11210	COG1902	pentaerythritol trinitrate reductase activity
K04M3_RS11210	COG0446	pyridine nucleotide-disulphide oxidoreductase
K04M3_RS11215	COG0616	signal peptide processing
K04M3_RS11220	COG0252	asparaginase activity
K04M3_RS11225	COG3139	Protein of unknown function (DUF1315)
K04M3_RS11235	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K04M3_RS11240	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K04M3_RS11255	COG2226	methyltransferase
K04M3_RS11270	COG1785	Belongs to the alkaline phosphatase family
K04M3_RS11280	COG0346	lactoylglutathione lyase activity
K04M3_RS11285	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
K04M3_RS11290	COG0668	transmembrane transport
K04M3_RS11295	COG2983	Belongs to the UPF0260 family
K04M3_RS11300	COG2261	transglycosylase associated protein
K04M3_RS11310	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K04M3_RS11315	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K04M3_RS11330	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K04M3_RS11335	COG2832	Protein of unknown function (DUF454)
K04M3_RS11345	COG0745	RESPONSE REGULATOR receiver
K04M3_RS11350	COG0583	DNA-binding transcription factor activity
K04M3_RS11355	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
K04M3_RS11360	COG1286	toxin biosynthetic process
K04M3_RS11365	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
K04M3_RS11370	COG0285	dihydrofolate synthase activity
K04M3_RS11375	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K04M3_RS11385	COG0101	tRNA pseudouridine synthase activity
K04M3_RS11395	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K04M3_RS11400	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K04M3_RS11410	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K04M3_RS11415	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
K04M3_RS11415	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K04M3_RS11420	COG0431	NADPH-dependent FMN reductase
K04M3_RS11435	COG3101	peptidyl-lysine hydroxylation
K04M3_RS11445	COG2860	membrane
K04M3_RS11450	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K04M3_RS11455	COG2890	protein-(glutamine-N5) methyltransferase activity
K04M3_RS11460	COG2840	Smr protein MutS2
K04M3_RS11465	COG2062	phosphohistidine phosphatase, SixA
K04M3_RS11480	COG1024	Enoyl-CoA hydratase
K04M3_RS11480	COG1250	3-hydroxyacyl-CoA dehydrogenase
K04M3_RS11485	COG0183	Belongs to the thiolase family
K04M3_RS11510	COG2067	long-chain fatty acid transport protein
K04M3_RS11520	COG3088	subunit of a heme lyase
K04M3_RS11520	COG4235	cytochrome complex assembly
K04M3_RS11530	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K04M3_RS11535	COG1138	Cytochrome C-type biogenesis protein
K04M3_RS11540	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
K04M3_RS11545	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K04M3_RS11550	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K04M3_RS11555	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K04M3_RS11560	COG4133	protoheme IX ABC transporter activity
K04M3_RS11570	COG0835	chemotaxis
K04M3_RS11580	COG1192	Involved in chromosome partitioning
K04M3_RS11585	COG2201	protein-glutamate methylesterase activity
K04M3_RS11590	COG2198	Histidine kinase
K04M3_RS11590	COG0643	Histidine kinase
K04M3_RS11590	COG0784	Response regulator, receiver
K04M3_RS11595	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
K04M3_RS11630	COG1684	flagellar biosynthetic protein fliR
K04M3_RS11635	COG1987	bacterial-type flagellum assembly
K04M3_RS11690	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K04M3_RS11700	COG1677	Flagellar hook-basal body complex protein FliE
K04M3_RS11720	COG1516	flagellar protein fliS
K04M3_RS11730	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
K04M3_RS11735	COG1334	flagellar protein FlaG
K04M3_RS11740	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K04M3_RS11745	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K04M3_RS11755	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K04M3_RS11760	COG2837	iron assimilation
K04M3_RS11785	COG1393	Belongs to the ArsC family
K04M3_RS11790	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K04M3_RS11805	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
K04M3_RS11810	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K04M3_RS11820	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K04M3_RS11845	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K04M3_RS11860	COG1053	succinate dehydrogenase
K04M3_RS11925	COG0210	DNA helicase
K04M3_RS11940	COG2205	protein histidine kinase activity
K04M3_RS11940	COG0784	Response regulator, receiver
K04M3_RS11950	COG1278	Cold shock
K04M3_RS11970	COG1278	Cold shock
K04M3_RS11975	COG4974	Belongs to the 'phage' integrase family
K04M3_RS11980	COG0330	HflC and HflK could
K04M3_RS12000	COG1278	Cold shock
K04M3_RS12020	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K04M3_RS12035	COG4783	chaperone-mediated protein folding
K04M3_RS12040	COG1393	Belongs to the ArsC family
K04M3_RS12060	COG2233	PERMEase
K04M3_RS12065	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K04M3_RS12070	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K04M3_RS12075	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K04M3_RS12080	COG0121	glutamine amidotransferase
K04M3_RS12085	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
K04M3_RS12090	COG1960	acyl-CoA dehydrogenase activity
K04M3_RS12125	COG0328	RNA-DNA hybrid ribonuclease activity
K04M3_RS12130	COG2226	methyltransferase
K04M3_RS12135	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K04M3_RS12140	COG1388	LysM domain
K04M3_RS12140	COG0741	lytic transglycosylase activity
K04M3_RS12150	COG3021	interspecies interaction between organisms
K04M3_RS12155	COG0347	Belongs to the P(II) protein family
K04M3_RS12170	COG0825	malonyl-CoA metabolic process
K04M3_RS12175	COG0587	DNA-directed DNA polymerase activity
K04M3_RS12185	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K04M3_RS12190	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K04M3_RS12200	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K04M3_RS12205	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
K04M3_RS12215	COG0750	zinc metalloprotease
K04M3_RS12220	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
K04M3_RS12225	COG0575	Belongs to the CDS family
K04M3_RS12230	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K04M3_RS12235	COG0233	cytoplasmic translational termination
K04M3_RS12240	COG0528	UMP kinase activity
K04M3_RS12245	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K04M3_RS12250	COG0052	Belongs to the universal ribosomal protein uS2 family
K04M3_RS12255	COG0024	Methionine aminopeptidase
K04M3_RS12260	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
K04M3_RS12270	COG0564	pseudouridine synthase activity
K04M3_RS12275	COG3098	single-species biofilm formation
K04M3_RS12310	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K04M3_RS12315	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K04M3_RS12340	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
K04M3_RS12350	COG0254	rRNA binding
K04M3_RS12355	COG1720	tRNA m6t6A37 methyltransferase activity
K04M3_RS12360	COG0442	prolyl-tRNA aminoacylation
K04M3_RS12380	COG0733	neurotransmitter:sodium symporter activity
K04M3_RS12395	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K04M3_RS12400	COG0514	ATP-dependent DNA helicase (RecQ)
K04M3_RS12425	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K04M3_RS12475	COG3621	Patatin-like phospholipase
K04M3_RS12510	COG0659	secondary active sulfate transmembrane transporter activity
K04M3_RS12515	COG0589	response to stress
K04M3_RS12520	COG0519	Catalyzes the synthesis of GMP from XMP
K04M3_RS12580	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K04M3_RS12600	COG1477	protein flavinylation
K04M3_RS12605	COG2871	sodium ion transport
K04M3_RS12610	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K04M3_RS12615	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K04M3_RS12620	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K04M3_RS12625	COG1805	sodium ion transport
K04M3_RS12630	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K04M3_RS12635	COG0271	Belongs to the BolA IbaG family
K04M3_RS12640	COG2813	Specifically methylates the guanine in position
K04M3_RS12645	COG3056	Lipoprotein
K04M3_RS12665	COG1595	DNA-templated transcription, initiation
K04M3_RS12690	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K04M3_RS12695	COG0693	protein deglycase activity
K04M3_RS12700	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K04M3_RS12705	COG3706	GGDEF domain
K04M3_RS12710	COG2166	iron-sulfur cluster assembly
K04M3_RS12715	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
K04M3_RS12720	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
K04M3_RS12735	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
K04M3_RS12735	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K04M3_RS12745	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K04M3_RS12750	COG1074	ATP-dependent DNA helicase activity
K04M3_RS12760	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
K04M3_RS12795	COG0270	DNA (cytosine-5-)-methyltransferase activity
K04M3_RS12820	COG3141	response to X-ray
K04M3_RS12835	COG2171	N-acyltransferase activity
K04M3_RS12840	COG0584	glycerophosphoryl diester phosphodiesterase
K04M3_RS12845	COG2271	Major facilitator Superfamily
K04M3_RS12855	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K04M3_RS12860	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
K04M3_RS12865	COG1349	DNA-binding transcription factor activity
K04M3_RS12870	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
K04M3_RS12875	COG0598	Magnesium transport protein CorA
K04M3_RS12895	COG1609	Transcriptional regulator
K04M3_RS12900	COG0583	DNA-binding transcription factor activity
K04M3_RS12940	COG1022	Amp-dependent synthetase and ligase
K04M3_RS12950	COG0583	DNA-binding transcription factor activity
K04M3_RS12955	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K04M3_RS12960	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
K04M3_RS12970	COG0560	Phosphoserine phosphatase
K04M3_RS12980	COG0813	purine-nucleoside phosphorylase activity
K04M3_RS12985	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
K04M3_RS12990	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
K04M3_RS12995	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
K04M3_RS13000	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K04M3_RS13005	COG0084	hydrolase, TatD family'
K04M3_RS13035	COG3153	acetyltransferase
K04M3_RS13040	COG3154	lipid carrier protein
K04M3_RS13055	COG0826	peptidase U32
K04M3_RS13060	COG0826	peptidase U32
K04M3_RS13065	COG0534	Mate efflux family protein
K04M3_RS13080	COG1185	polyribonucleotide nucleotidyltransferase activity
K04M3_RS13085	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K04M3_RS13090	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K04M3_RS13095	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K04M3_RS13100	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K04M3_RS13105	COG0195	Participates in both transcription termination and antitermination
K04M3_RS13110	COG0779	Required for maturation of 30S ribosomal subunits
K04M3_RS13125	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K04M3_RS13135	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K04M3_RS13140	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
K04M3_RS13145	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K04M3_RS13150	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
K04M3_RS13155	COG1534	Rna-binding protein
K04M3_RS13160	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K04M3_RS13165	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K04M3_RS13170	COG2027	D-alanyl-D-alanine carboxypeptidase
K04M3_RS13180	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K04M3_RS13185	COG0739	heme binding
K04M3_RS13210	COG0628	permease
K04M3_RS13220	COG0784	Response regulator, receiver
K04M3_RS13220	COG2205	protein histidine kinase activity
K04M3_RS13225	COG0747	negative chemotaxis
K04M3_RS13235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K04M3_RS13240	COG0444	Belongs to the ABC transporter superfamily
K04M3_RS13245	COG4608	Belongs to the ABC transporter superfamily
K04M3_RS13255	COG2971	BadF BadG BcrA BcrD
K04M3_RS13270	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K04M3_RS13275	COG3842	ATPase activity
K04M3_RS13285	COG1840	ABC-type Fe3 transport system, periplasmic component
K04M3_RS13290	COG0004	ammonium transporteR
K04M3_RS13300	COG3112	Uncharacterised protein family (UPF0231)
K04M3_RS13305	COG1049	propionate catabolic process, 2-methylcitrate cycle
K04M3_RS13310	COG1752	Esterase of the alpha-beta hydrolase superfamily
K04M3_RS13315	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K04M3_RS13320	COG1643	Atp-dependent helicase
K04M3_RS13325	COG1489	DNA binding
K04M3_RS13335	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K04M3_RS13345	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K04M3_RS13350	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
K04M3_RS13355	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
K04M3_RS13360	COG1560	Kdo2-lipid A biosynthetic process
K04M3_RS13370	COG0842	Transport permease protein
K04M3_RS13375	COG1131	(ABC) transporter
K04M3_RS13380	COG0659	secondary active sulfate transmembrane transporter activity
K04M3_RS13385	COG0288	reversible hydration of carbon dioxide
K04M3_RS13400	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K04M3_RS13405	COG0508	dehydrogenase complex catalyzes the overall conversion of
K04M3_RS13410	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
K04M3_RS13415	COG2186	Transcriptional regulator
K04M3_RS13425	COG0157	Belongs to the NadC ModD family
K04M3_RS13430	COG4969	Belongs to the N-Me-Phe pilin family
K04M3_RS13435	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K04M3_RS13440	COG1459	type II secretion system
K04M3_RS13450	COG0237	dephospho-CoA kinase activity
K04M3_RS13455	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
K04M3_RS13460	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
K04M3_RS13475	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K04M3_RS13480	COG0228	four-way junction DNA binding
K04M3_RS13485	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K04M3_RS13490	COG4137	Cytochrome C assembly protein
K04M3_RS13495	COG4536	flavin adenine dinucleotide binding
K04M3_RS13500	COG1854	S-ribosylhomocysteine lyase activity
K04M3_RS13515	COG0612	Peptidase, M16
K04M3_RS13520	COG1238	metal cluster binding
K04M3_RS13530	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
K04M3_RS13535	COG5016	pyruvate
K04M3_RS13535	COG0511	ligase activity, forming carbon-carbon bonds
K04M3_RS13540	COG3630	sodium ion export across plasma membrane
K04M3_RS13600	COG0527	aspartate kinase activity
K04M3_RS13605	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K04M3_RS13610	COG2137	regulation of response to DNA damage stimulus
K04M3_RS13615	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K04M3_RS13620	COG1546	Belongs to the CinA family
K04M3_RS13625	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K04M3_RS13630	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K04M3_RS13640	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K04M3_RS13645	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
K04M3_RS13655	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
K04M3_RS13660	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
K04M3_RS13665	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
K04M3_RS13670	COG0148	phosphopyruvate hydratase activity
K04M3_RS13675	COG0504	CTP synthase activity
K04M3_RS13680	COG3956	TIGRFAM MazG family protein
K04M3_RS13685	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K04M3_RS13690	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K04M3_RS13705	COG0736	holo-[acyl-carrier-protein] synthase activity
K04M3_RS13710	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
K04M3_RS13715	COG1381	Involved in DNA repair and RecF pathway recombination
K04M3_RS13720	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K04M3_RS13730	COG0681	Belongs to the peptidase S26 family
K04M3_RS13735	COG0481	GTPase activity
K04M3_RS13740	COG3086	response to oxidative stress
K04M3_RS13755	COG1595	DNA-templated transcription, initiation
K04M3_RS13760	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
K04M3_RS13770	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
K04M3_RS13790	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K04M3_RS13795	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K04M3_RS13800	COG3079	Belongs to the UPF0149 family
K04M3_RS13805	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
K04M3_RS13815	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K04M3_RS13820	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
K04M3_RS13825	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K04M3_RS13835	COG0583	DNA-binding transcription factor activity
K04M3_RS13850	COG0668	transmembrane transport
K04M3_RS13855	COG0191	fructose-bisphosphate aldolase activity
K04M3_RS13870	COG4771	TonB-dependent receptor
K04M3_RS13875	COG0583	DNA-binding transcription factor activity
K04M3_RS13880	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K04M3_RS13890	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K04M3_RS13900	COG3091	SprT-like family
K04M3_RS13905	COG2356	endonuclease I
K04M3_RS13910	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K04M3_RS13915	COG0189	ligase activity
K04M3_RS13920	COG1678	Uncharacterized ACR, COG1678
K04M3_RS13925	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K04M3_RS13940	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K04M3_RS13945	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K04M3_RS13950	COG0762	integral membrane protein
K04M3_RS13955	COG1872	DUF167
K04M3_RS13965	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
K04M3_RS13970	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K04M3_RS13975	COG2066	Belongs to the glutaminase family
K04M3_RS13985	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K04M3_RS13995	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
K04M3_RS14040	COG0840	transmembrane signaling receptor activity
K04M3_RS14120	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
K04M3_RS14125	COG1609	Transcriptional regulator
K04M3_RS14130	COG3394	polysaccharide catabolic process
K04M3_RS14135	COG1486	melibiose metabolic process
K04M3_RS14140	COG1447	Phosphotransferase system cellobiose-specific component IIA
K04M3_RS14145	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K04M3_RS14150	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K04M3_RS14155	COG0726	polysaccharide deacetylase
K04M3_RS14165	COG1028	Short-chain dehydrogenase reductase Sdr
K04M3_RS14180	COG0795	lipopolysaccharide-transporting ATPase activity
K04M3_RS14185	COG0795	lipopolysaccharide-transporting ATPase activity
K04M3_RS14190	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K04M3_RS14195	COG2927	DNA polymerase III (CHI subunit)
K04M3_RS14200	COG0525	valine-tRNA ligase activity
K04M3_RS14210	COG0456	acetyltransferase
K04M3_RS14240	COG0540	Belongs to the ATCase OTCase family
K04M3_RS14245	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
K04M3_RS14250	COG0251	oxidation-reduction process
K04M3_RS14255	COG0204	Acyl-transferase
K04M3_RS14260	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K04M3_RS14265	COG5007	Belongs to the BolA IbaG family
K04M3_RS14275	COG2854	intermembrane phospholipid transfer
K04M3_RS14280	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K04M3_RS14285	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K04M3_RS14290	COG1127	ABC transporter
K04M3_RS14300	COG0517	IMP dehydrogenase activity
K04M3_RS14300	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
K04M3_RS14310	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
K04M3_RS14315	COG1137	ATPase activity
K04M3_RS14325	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K04M3_RS14330	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K04M3_RS14335	COG1660	Displays ATPase and GTPase activities
K04M3_RS14340	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K04M3_RS14345	COG2239	Acts as a magnesium transporter
K04M3_RS14350	COG0312	modulator of DNA gyrase
K04M3_RS14355	COG3028	Belongs to the UPF0307 family
K04M3_RS14360	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K04M3_RS14365	COG0564	pseudouridine synthase activity
K04M3_RS14375	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K04M3_RS14380	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
K04M3_RS14385	COG0312	modulator of DNA gyrase
K04M3_RS14390	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K04M3_RS14395	COG3164	Protein of unknown function
K04M3_RS14405	COG0424	maF-like protein
K04M3_RS14410	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
K04M3_RS14415	COG1792	Involved in formation and maintenance of cell shape
K04M3_RS14420	COG1077	Cell shape determining protein MreB Mrl
K04M3_RS14455	COG2165	general secretion pathway protein
K04M3_RS14465	COG1459	type II secretion system
K04M3_RS14470	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K04M3_RS14480	COG3267	Type II secretory pathway component ExeA
K04M3_RS14480	COG3409	Peptidoglycan-binding domain 1 protein
K04M3_RS14485	COG1450	Type ii and iii secretion system protein
K04M3_RS14505	COG2199	diguanylate cyclase activity
K04M3_RS14505	COG2200	EAL domain
K04M3_RS14510	COG0629	single-stranded DNA binding
K04M3_RS14525	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K04M3_RS14540	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
K04M3_RS14550	COG0527	aspartate kinase activity
K04M3_RS14555	COG0646	methionine synthase
K04M3_RS14555	COG1410	methionine synthase
K04M3_RS14625	COG0175	sulfate reduction
K04M3_RS14630	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K04M3_RS14635	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K04M3_RS14655	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K04M3_RS14660	COG0735	belongs to the Fur family
K04M3_RS14670	COG0166	Belongs to the GPI family
K04M3_RS14675	COG0432	Pfam Uncharacterised protein family UPF0047
K04M3_RS14680	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K04M3_RS14705	COG2965	DNA replication, synthesis of RNA primer
K04M3_RS14710	COG0360	Binds together with S18 to 16S ribosomal RNA
K04M3_RS14715	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K04M3_RS14720	COG0338	D12 class N6 adenine-specific DNA methyltransferase
K04M3_RS14730	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K04M3_RS14735	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K04M3_RS14765	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
K04M3_RS14775	COG0678	peroxiredoxin activity
K04M3_RS14775	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K04M3_RS14780	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K04M3_RS14795	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
K04M3_RS14795	COG0165	Argininosuccinate lyase
K04M3_RS14800	COG0137	argininosuccinate synthase activity
K04M3_RS14810	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
K04M3_RS14820	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
K04M3_RS14830	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K04M3_RS14835	COG0460	homoserine dehydrogenase
K04M3_RS14835	COG0527	aspartate kinase activity
K04M3_RS14840	COG0626	cystathionine gamma-synthase activity
K04M3_RS14845	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
K04M3_RS14850	COG0281	malic enzyme
K04M3_RS14865	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K04M3_RS14870	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K04M3_RS14890	COG2923	Belongs to the DsrF TusC family
K04M3_RS14895	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
K04M3_RS14900	COG2964	Protein conserved in bacteria
K04M3_RS14905	COG0545	Peptidyl-prolyl cis-trans isomerase
K04M3_RS14920	COG1446	asparaginase
K04M3_RS14930	COG1047	Peptidyl-prolyl cis-trans
K04M3_RS14945	COG2249	NAD(P)H dehydrogenase (quinone) activity
K04M3_RS14950	COG0488	(ABC) transporter
K04M3_RS14960	COG0429	hydrolase of the alpha beta-hydrolase fold
K04M3_RS14970	COG3954	Phosphoribulokinase
K04M3_RS14975	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K04M3_RS14995	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K04M3_RS15000	COG0512	Glutamine amidotransferase of anthranilate synthase
K04M3_RS15015	COG0180	Tryptophanyl-tRNA synthetase
K04M3_RS15020	COG0546	phosphoglycolate phosphatase activity
K04M3_RS15025	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K04M3_RS15030	COG0557	exoribonuclease II activity
K04M3_RS15035	COG1959	2 iron, 2 sulfur cluster binding
K04M3_RS15040	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K04M3_RS15040	COG1017	nitric oxide dioxygenase activity
K04M3_RS15045	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
K04M3_RS15050	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K04M3_RS15055	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
K04M3_RS15060	COG0330	HflC and HflK could
K04M3_RS15065	COG0330	HflC and HflK could
K04M3_RS15070	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K04M3_RS15080	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K04M3_RS15085	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K04M3_RS15095	COG0802	atpase or kinase
K04M3_RS15105	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K04M3_RS15170	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
K04M3_RS15175	COG1162	GTPase activity
K04M3_RS15180	COG0688	phosphatidylethanolamine metabolic process
K04M3_RS15185	COG0471	metal ion transport
K04M3_RS15195	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
K04M3_RS15200	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K04M3_RS15205	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
K04M3_RS15210	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K04M3_RS15215	COG1045	serine acetyltransferase
K04M3_RS15220	COG4942	peptidase
K04M3_RS15240	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
K04M3_RS15245	COG1053	succinate dehydrogenase
K04M3_RS15250	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K04M3_RS15255	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
K04M3_RS15260	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
K04M3_RS15275	COG1509	lysine 2,3-aminomutase activity
K04M3_RS15280	COG1285	pathogenesis
K04M3_RS15290	COG0459	protein refolding
K04M3_RS15305	COG0534	Mate efflux family protein
K04M3_RS15310	COG0205	6-phosphofructokinase activity
K04M3_RS15320	COG3678	ATP-independent chaperone mediated protein folding
K04M3_RS15325	COG0745	RESPONSE REGULATOR receiver
K04M3_RS15330	COG2205	protein histidine kinase activity
K04M3_RS15340	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
K04M3_RS15345	COG3030	protein affecting phage T7 exclusion by the F plasmid
K04M3_RS15350	COG1027	Aspartate ammonia-lyase
K04M3_RS15355	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
K04M3_RS15360	COG4232	protein-disulfide reductase activity
K04M3_RS15370	COG3263	regulation of cellular component size
K04M3_RS15380	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K04M3_RS15405	COG2814	Major facilitator Superfamily
K04M3_RS15420	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K04M3_RS15425	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K04M3_RS15430	COG0511	ligase activity, forming carbon-carbon bonds
K04M3_RS15435	COG0439	Biotin carboxylase
K04M3_RS15440	COG2264	protein methyltransferase activity
K04M3_RS15445	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K04M3_RS15450	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
K04M3_RS15460	COG0488	(ABC) transporter
K04M3_RS15510	COG1982	Orn Lys Arg decarboxylase major
K04M3_RS15515	COG0531	amino acid
K04M3_RS15525	COG3710	Transcriptional regulator
K04M3_RS15530	COG0789	Transcriptional regulator
K04M3_RS15545	COG0151	Belongs to the GarS family
K04M3_RS15560	COG1253	flavin adenine dinucleotide binding
K04M3_RS15565	COG3068	Protein conserved in bacteria
K04M3_RS15575	COG1573	uracil-dna glycosylase
K04M3_RS15580	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K04M3_RS15585	COG2816	NAD+ diphosphatase activity
K04M3_RS15590	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
K04M3_RS15595	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K04M3_RS15600	COG0085	RNA polymerase activity
K04M3_RS15605	COG0222	ribosome binding
K04M3_RS15610	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K04M3_RS15625	COG0250	Participates in transcription elongation, termination and antitermination
K04M3_RS15630	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K04M3_RS15640	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K04M3_RS15675	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
K04M3_RS15675	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
K04M3_RS15680	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K04M3_RS15690	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K04M3_RS15765	COG4206	TonB-dependent receptor
K04M3_RS15785	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K04M3_RS15790	COG0534	Mate efflux family protein
K04M3_RS15795	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
K04M3_RS15805	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K04M3_RS15815	COG2937	Belongs to the GPAT DAPAT family
K04M3_RS15820	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
K04M3_RS15825	COG3161	chorismate lyase activity
K04M3_RS15830	COG1580	Controls the rotational direction of flagella during chemotaxis
K04M3_RS15835	COG0705	Rhomboid family
K04M3_RS15840	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K04M3_RS15855	COG2177	Part of the ABC transporter FtsEX involved in
K04M3_RS15860	COG2884	Cell division ATP-binding protein ftsE
K04M3_RS15865	COG0552	protein localization to endoplasmic reticulum
K04M3_RS15870	COG0742	ribosomal rna small subunit methyltransferase
K04M3_RS15880	COG2095	MarC family integral membrane protein
K04M3_RS15930	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K04M3_RS15935	COG0640	Transcriptional regulator
K04M3_RS15940	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
K04M3_RS15945	COG1280	lysine exporter protein (LysE YggA)
K04M3_RS15950	COG2267	carboxylic ester hydrolase activity
K04M3_RS15955	COG0561	phosphatase activity
K04M3_RS15970	COG3148	PFAM DTW domain containing protein
K04M3_RS15975	COG2199	diguanylate cyclase activity
K04M3_RS15975	COG3287	FIST C domain
K04M3_RS15975	COG2200	EAL domain
K04M3_RS15980	COG1011	Hydrolase
K04M3_RS15985	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
K04M3_RS16000	COG0019	diaminopimelate decarboxylase activity
K04M3_RS16010	COG1965	Belongs to the frataxin family
K04M3_RS16015	COG3072	Adenylate cyclase
K04M3_RS16020	COG0181	hydroxymethylbilane synthase activity
K04M3_RS16025	COG1587	Uroporphyrinogen-III synthase
K04M3_RS16030	COG2959	enzyme of heme biosynthesis
K04M3_RS16035	COG3071	HemY protein
K04M3_RS16075	COG0633	Ferredoxin
K04M3_RS16080	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
K04M3_RS16095	COG3118	belongs to the thioredoxin family
K04M3_RS16100	COG0513	Belongs to the DEAD box helicase family
K04M3_RS16105	COG0248	Ppx GppA phosphatase
K04M3_RS16115	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
K04M3_RS16125	COG0514	ATP-dependent DNA helicase (RecQ)
K04M3_RS16130	COG2962	Rard protein
K04M3_RS16140	COG1280	lysine exporter protein (LysE YggA)
K04M3_RS16145	COG0405	Gamma-glutamyltransferase
K04M3_RS16150	COG0210	DNA helicase
K04M3_RS16160	COG3220	belongs to the UPF0276 family
K04M3_RS16190	COG0006	proline dipeptidase activity
K04M3_RS16190	COG0006	proline dipeptidase activity
K04M3_RS16205	COG2104	thiamine diphosphate biosynthetic process
K04M3_RS16210	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K04M3_RS16230	COG2132	Multicopper oxidase
K04M3_RS16280	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
K04M3_RS16300	COG0009	L-threonylcarbamoyladenylate synthase
K04M3_RS16305	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
K04M3_RS16310	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K04M3_RS16315	COG0551	DNA topoisomerase type I activity
K04M3_RS16320	COG2922	Belongs to the Smg family
K04M3_RS16325	COG0758	DNA mediated transformation
K04M3_RS16335	COG0242	peptide deformylase activity
K04M3_RS16340	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K04M3_RS16345	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K04M3_RS16345	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K04M3_RS16350	COG0569	domain protein
K04M3_RS16355	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K04M3_RS16365	COG1272	protein, Hemolysin III
K04M3_RS16370	COG4326	sporulation control protein
K04M3_RS16380	COG3084	Protein conserved in bacteria
K04M3_RS16390	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
K04M3_RS16395	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K04M3_RS16400	COG0204	Acyl-transferase
K04M3_RS16410	COG0606	chelatase, subunit chli
K04M3_RS16420	COG3978	acetolactate synthase activity
K04M3_RS16425	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K04M3_RS16430	COG0129	dihydroxy-acid dehydratase activity
K04M3_RS16440	COG0583	DNA-binding transcription factor activity
K04M3_RS16445	COG2814	Major facilitator Superfamily
K04M3_RS16455	COG0765	amino acid transport
K04M3_RS16465	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K04M3_RS16470	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K04M3_RS16475	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K04M3_RS16480	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K04M3_RS16485	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K04M3_RS16490	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K04M3_RS16500	COG0356	it plays a direct role in the translocation of protons across the membrane
K04M3_RS16505	COG3312	ion transport
K04M3_RS16510	COG1475	DNA binding
K04M3_RS16515	COG1192	Involved in chromosome partitioning
K04M3_RS16520	COG0357	Ribosomal RNA small subunit methyltransferase G
K04M3_RS16525	COG0445	tRNA wobble uridine modification
K04M3_RS16530	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K04M3_RS16540	COG0706	membrane insertase activity
K04M3_RS16550	COG0594	ribonuclease P activity
K04M3_RS16560	COG1126	abc transporter atp-binding protein
K04M3_RS16585	COG1444	tRNA N-acetyltransferase activity
K04M3_RS16605	COG3340	Belongs to the peptidase S51 family
K04M3_RS16610	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K04M3_RS16615	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K04M3_RS16615	COG1263	PTS System
K04M3_RS16620	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
K04M3_RS16635	COG4166	transmembrane transport
K04M3_RS16680	COG0259	pyridoxamine-phosphate oxidase activity
K04M3_RS16705	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K04M3_RS16745	COG1132	(ABC) transporter
K04M3_RS16755	COG0513	Belongs to the DEAD box helicase family
K04M3_RS16760	COG2258	MOSC domain
K04M3_RS16815	COG3634	alkyl hydroperoxide reductase activity
K04M3_RS16860	COG1846	Transcriptional regulator
K04M3_RS16865	COG1764	response to oxidative stress
K04M3_RS16900	COG0577	efflux transmembrane transporter activity
K04M3_RS16905	COG1136	(ABC) transporter
K04M3_RS16920	COG0826	peptidase U32
K04M3_RS16945	COG1653	transport
K04M3_RS16950	COG0019	diaminopimelate decarboxylase activity
K04M3_RS16955	COG4264	IucA IucC family
K04M3_RS16980	COG4772	TonB-dependent receptor
K04M3_RS16985	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
K04M3_RS16995	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K04M3_RS17000	COG1120	ATPase activity
K04M3_RS17005	COG0840	transmembrane signaling receptor activity
K04M3_RS17010	COG0612	Peptidase, M16
K04M3_RS17020	COG0739	heme binding
K04M3_RS17035	COG2814	Major facilitator Superfamily
K04M3_RS17045	COG1609	Transcriptional regulator
K04M3_RS17050	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K04M3_RS17070	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K04M3_RS17070	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K04M3_RS17080	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K04M3_RS17085	COG1609	Transcriptional regulator
K04M3_RS17095	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K04M3_RS17110	COG0596	Alpha beta hydrolase
K04M3_RS17135	COG1760	l-serine dehydratase
K04M3_RS17145	COG4580	involved in the transport of maltose and maltodextrins
K04M3_RS17165	COG2356	endonuclease I
K04M3_RS17185	COG1982	Orn Lys Arg decarboxylase major
K04M3_RS17190	COG0531	amino acid
K04M3_RS17200	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
K04M3_RS17205	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
K04M3_RS17210	COG1162	GTPase activity
K04M3_RS17215	COG1263	PTS System
K04M3_RS17215	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K04M3_RS17220	COG1999	signal sequence binding
K04M3_RS17235	COG2909	trisaccharide binding
K04M3_RS17245	COG0058	SHG alpha-glucan phosphorylase activity
K04M3_RS17250	COG1640	4-alpha-glucanotransferase
K04M3_RS17255	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
K04M3_RS17260	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K04M3_RS17265	COG0366	Alpha amylase catalytic
K04M3_RS17280	COG3366	ferrous iron transmembrane transporter activity
K04M3_RS17285	COG0700	Nucleoside recognition
K04M3_RS17290	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K04M3_RS17295	COG3339	Conserved Protein
K04M3_RS17300	COG1301	dicarboxylic acid transport
K04M3_RS17310	COG0583	DNA-binding transcription factor activity
K04M3_RS17330	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K04M3_RS17335	COG1596	polysaccharide export
K04M3_RS17350	COG2095	MarC family integral membrane protein
K04M3_RS17355	COG4667	esterase of the alpha-beta hydrolase superfamily
K04M3_RS17360	COG3397	chitin binding
K04M3_RS17365	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
K04M3_RS17370	COG0415	Belongs to the DNA photolyase family
K04M3_RS17380	COG1054	Belongs to the UPF0176 family
K04M3_RS17390	COG1686	Belongs to the peptidase S11 family
K04M3_RS17415	COG0583	DNA-binding transcription factor activity
K04M3_RS17420	COG4628	conserved protein (DUF2132)
K04M3_RS17440	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
K04M3_RS17445	COG0628	permease
K04M3_RS17470	COG1289	transmembrane transporter activity
K04M3_RS17490	COG2814	Major facilitator Superfamily
K04M3_RS17500	COG0454	-acetyltransferase
K04M3_RS17510	COG0745	RESPONSE REGULATOR receiver
K04M3_RS17515	COG2205	protein histidine kinase activity
K04M3_RS17530	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K04M3_RS17535	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K04M3_RS17540	COG1882	Formate acetyltransferase
K04M3_RS17575	COG1360	Flagellar Motor Protein
K04M3_RS17580	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K04M3_RS17585	COG1191	sigma factor activity
K04M3_RS17590	COG1580	Controls the rotational direction of flagella during chemotaxis
K04M3_RS17605	COG1516	flagellar protein fliS
K04M3_RS17610	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
K04M3_RS17620	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K04M3_RS17635	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K04M3_RS17645	COG1987	bacterial-type flagellum assembly
K04M3_RS17685	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K04M3_RS17745	COG0346	lactoylglutathione lyase activity
K04M3_RS17770	COG0745	RESPONSE REGULATOR receiver
K04M3_RS17795	COG5001	Diguanylate cyclase
K04M3_RS17795	COG3300	MHYT domain
K04M3_RS17800	COG0156	8-amino-7-oxononanoate synthase activity
K04M3_RS17805	COG1063	alcohol dehydrogenase
K04M3_RS17840	COG0668	transmembrane transport
K04M3_RS17850	COG1304	FMN binding
K04M3_RS17855	COG1620	l-lactate permease
K04M3_RS17860	COG0583	DNA-binding transcription factor activity
K04M3_RS17865	COG1505	serine-type exopeptidase activity
K04M3_RS17870	COG4172	Belongs to the ABC transporter superfamily
K04M3_RS17880	COG1067	ATP-dependent peptidase activity
K04M3_RS17890	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K04M3_RS17910	COG1247	-acetyltransferase
K04M3_RS17915	COG0437	4 iron, 4 sulfur cluster binding
K04M3_RS17920	COG0348	domain, Protein
K04M3_RS17940	COG1122	ATPase activity
K04M3_RS17945	COG4720	Psort location CytoplasmicMembrane, score
K04M3_RS17950	COG1566	PFAM secretion protein HlyD family protein
K04M3_RS17975	COG0813	purine-nucleoside phosphorylase activity
K04M3_RS17980	COG3272	Protein of unknown function (DUF1722)
K04M3_RS17985	COG0789	Transcriptional regulator
K04M3_RS17990	COG0415	Belongs to the DNA photolyase family
K04M3_RS17995	COG1376	ErfK ybiS ycfS ynhG family protein
K04M3_RS17995	COG1388	LysM domain
K04M3_RS18005	COG0513	Belongs to the DEAD box helicase family
K04M3_RS18010	COG1770	oligopeptidase
K04M3_RS18015	COG4771	TonB-dependent receptor
K04M3_RS18045	COG0573	inorganic phosphate transmembrane transporter activity
K04M3_RS18050	COG0581	inorganic phosphate transmembrane transporter activity
K04M3_RS18055	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K04M3_RS18070	COG2304	oxidoreductase activity
K04M3_RS18090	COG0714	Associated with various cellular activities
K04M3_RS18105	COG2197	response regulator
K04M3_RS18140	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
K04M3_RS18145	COG1120	ATPase activity
K04M3_RS18150	COG4774	siderophore transport
K04M3_RS18155	COG1132	(ABC) transporter
K04M3_RS18160	COG2205	protein histidine kinase activity
K04M3_RS18170	COG0569	domain protein
K04M3_RS18175	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K04M3_RS18180	COG0583	DNA-binding transcription factor activity
K04M3_RS18195	COG1012	belongs to the aldehyde dehydrogenase family
K04M3_RS18200	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K04M3_RS18205	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K04M3_RS18215	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
K04M3_RS18220	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K04M3_RS18250	COG2084	Dehydrogenase
K04M3_RS18255	COG0753	catalase activity
K04M3_RS18265	COG2130	NADP-dependent
K04M3_RS18270	COG1309	transcriptional regulator
K04M3_RS18275	COG3097	Belongs to the UPF0267 family
K04M3_RS18315	COG3206	protein involved in exopolysaccharide biosynthesis
K04M3_RS18315	COG0489	protein tyrosine kinase activity
K04M3_RS18330	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K04M3_RS18335	COG3842	ATPase activity
K04M3_RS18345	COG1175	transmembrane transport
K04M3_RS18350	COG3833	ABC-type maltose transport systems, permease component
K04M3_RS18370	COG2207	Transcriptional regulator
K04M3_RS18370	COG4753	response regulator
K04M3_RS18380	COG2354	Protein conserved in bacteria
K04M3_RS18385	COG0418	dihydroorotase activity
K04M3_RS18395	COG0401	homolog of Blt101
K04M3_RS18400	COG3217	Mosc domain protein beta barrel domain protein
K04M3_RS18400	COG0633	Ferredoxin
K04M3_RS18400	COG3217	Mosc domain protein beta barrel domain protein
K04M3_RS18400	COG0633	Ferredoxin
K04M3_RS18410	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K04M3_RS18450	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
K04M3_RS18455	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K04M3_RS18465	COG0848	biopolymer transport protein
K04M3_RS18470	COG0811	peptide transport
K04M3_RS18475	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
K04M3_RS18485	COG3721	Heme iron utilization protein
K04M3_RS18490	COG0748	coenzyme F420 binding
K04M3_RS18500	COG0784	Response regulator, receiver
K04M3_RS18500	COG0835	chemotaxis
K04M3_RS18505	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K04M3_RS18510	COG0534	Mate efflux family protein
K04M3_RS18515	COG0444	Belongs to the ABC transporter superfamily
K04M3_RS18520	COG4608	Belongs to the ABC transporter superfamily
K04M3_RS18525	COG0747	negative chemotaxis
K04M3_RS18535	COG1349	DNA-binding transcription factor activity
K04M3_RS18540	COG2084	Dehydrogenase
K04M3_RS18545	COG3395	kinase activity
K04M3_RS18550	COG0235	Class ii aldolase
K04M3_RS18555	COG3622	Belongs to the hyi family
K04M3_RS18560	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K04M3_RS18565	COG2610	gluconate transmembrane transporter activity
K04M3_RS18585	COG0583	DNA-binding transcription factor activity
K04M3_RS18590	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K04M3_RS18600	COG4934	collagen metabolic process
K04M3_RS18610	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K04M3_RS18615	COG0789	Transcriptional regulator
K04M3_RS18620	COG0366	Alpha amylase catalytic
K04M3_RS18640	COG2249	NAD(P)H dehydrogenase (quinone) activity
K04M3_RS18645	COG0589	response to stress
K04M3_RS18650	COG0488	(ABC) transporter
K04M3_RS18655	COG1505	serine-type exopeptidase activity
K04M3_RS18665	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K04M3_RS18675	COG2067	long-chain fatty acid transport protein
K04M3_RS18685	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K04M3_RS18710	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K04M3_RS18730	COG3383	formate dehydrogenase (NAD+) activity
K04M3_RS18740	COG0842	Transport permease protein
K04M3_RS18745	COG1131	(ABC) transporter
K04M3_RS18765	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
K04M3_RS18775	COG4145	pantothenate transmembrane transporter activity
K04M3_RS18780	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K04M3_RS18785	COG0800	Aldolase
K04M3_RS18795	COG2706	6-phosphogluconolactonase activity
K04M3_RS18800	COG0251	oxidation-reduction process
K04M3_RS18810	COG1881	PFAM PEBP family protein
K04M3_RS18820	COG0798	PFAM Bile acid sodium symporter
K04M3_RS18835	COG1733	regulation of RNA biosynthetic process
K04M3_RS18860	COG4989	oxidoreductase activity
K04M3_RS18885	COG0814	amino acid
K04M3_RS18900	COG3314	Sporulation integral membrane protein YlbJ
K04M3_RS18920	COG0739	heme binding
K04M3_RS18925	COG5001	Diguanylate cyclase
K04M3_RS18930	COG0583	DNA-binding transcription factor activity
K04M3_RS18935	COG2814	Major facilitator Superfamily
K04M3_RS18955	COG0697	spore germination
K04M3_RS18970	COG0179	Fumarylacetoacetate (FAA) hydrolase
K04M3_RS18990	COG1280	lysine exporter protein (LysE YggA)
K04M3_RS19000	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K04M3_RS19005	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K04M3_RS19010	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K04M3_RS19015	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
K04M3_RS19020	COG1845	cytochrome c oxidase, subunit III
K04M3_RS19040	COG1612	heme a metabolic process
K04M3_RS19045	COG0109	protoheme IX farnesyltransferase activity
K04M3_RS19050	COG0545	Peptidyl-prolyl cis-trans isomerase
K04M3_RS19080	COG1278	Cold shock
K04M3_RS19085	COG3036	rescue of stalled ribosome
K04M3_RS19090	COG2199	diguanylate cyclase activity
K04M3_RS19105	COG1132	(ABC) transporter
K04M3_RS19110	COG1132	(ABC) transporter
K04M3_RS19115	COG1538	Outer membrane efflux protein
K04M3_RS19120	COG0784	Response regulator, receiver
K04M3_RS19120	COG2205	protein histidine kinase activity
K04M3_RS19145	COG0840	transmembrane signaling receptor activity
K04M3_RS19150	COG0783	Belongs to the Dps family
K04M3_RS19160	COG2133	pyrroloquinoline quinone binding
K04M3_RS19165	COG1454	alcohol dehydrogenase
K04M3_RS19170	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
K04M3_RS19190	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K04M3_RS19195	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K04M3_RS19200	COG3186	Phenylalanine-4-hydroxylase
K04M3_RS19225	COG3530	Putative quorum-sensing-regulated virulence factor
K04M3_RS19245	COG0513	Belongs to the DEAD box helicase family
K04M3_RS19250	COG4628	conserved protein (DUF2132)
K04M3_RS19260	COG0133	tryptophan synthase activity
K04M3_RS19270	COG1278	Cold shock
K04M3_RS19280	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
K04M3_RS19290	COG0523	cobalamin synthesis protein
K04M3_RS19295	COG0513	Belongs to the DEAD box helicase family
K04M3_RS19315	COG2200	EAL domain
K04M3_RS19320	COG1119	ATPase activity
K04M3_RS19355	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
K04M3_RS19360	COG0513	Belongs to the DEAD box helicase family
K04M3_RS19375	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K04M3_RS19385	COG1073	alpha beta
K04M3_RS19390	COG1073	alpha beta
K04M3_RS19405	COG0730	response to heat
K04M3_RS19425	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K04M3_RS19435	COG0523	cobalamin synthesis protein
K04M3_RS19440	COG2988	succinylglutamate desuccinylase activity
K04M3_RS19445	COG0739	heme binding
K04M3_RS19455	COG0523	cobalamin synthesis protein
K04M3_RS19475	COG2095	MarC family integral membrane protein
K04M3_RS19500	COG1024	Enoyl-CoA hydratase
K04M3_RS19505	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K04M3_RS19510	COG1960	acyl-CoA dehydrogenase activity
K04M3_RS19520	COG0183	Belongs to the thiolase family
K04M3_RS19535	COG1024	Enoyl-CoA hydratase
K04M3_RS19540	COG1024	Enoyl-CoA hydratase
K04M3_RS19550	COG1028	Short-chain dehydrogenase reductase Sdr
K04M3_RS19555	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K04M3_RS19560	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K04M3_RS19565	COG1845	cytochrome c oxidase, subunit III
K04M3_RS19570	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
K04M3_RS19575	COG0109	protoheme IX farnesyltransferase activity
K04M3_RS19580	COG1902	pentaerythritol trinitrate reductase activity
K04M3_RS19580	COG0446	pyridine nucleotide-disulphide oxidoreductase
K04M3_RS19595	COG1012	belongs to the aldehyde dehydrogenase family
K04M3_RS19605	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K04M3_RS19635	COG1126	abc transporter atp-binding protein
K04M3_RS19640	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K04M3_RS19645	COG4215	(ABC) transporter
K04M3_RS19650	COG4160	amino acid transport
K04M3_RS19715	COG0443	Heat shock 70 kDa protein
K04M3_RS19720	COG2847	Copper chaperone PCu(A)C
K04M3_RS19785	COG0814	amino acid
K04M3_RS19795	COG0243	molybdopterin cofactor binding
K04M3_RS19825	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K04M3_RS19825	COG1116	anion transmembrane transporter activity
K04M3_RS19830	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K04M3_RS19835	COG1116	anion transmembrane transporter activity
K04M3_RS19840	COG2146	nitrite reductase [NAD(P)H] activity
K04M3_RS19840	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K04M3_RS19890	COG2815	serine threonine protein kinase
K04M3_RS19890	COG0515	serine threonine protein kinase
K04M3_RS19925	COG0631	protein serine/threonine phosphatase activity
K04M3_RS19995	COG0420	3'-5' exonuclease activity
K04M3_RS20000	COG0419	ATPase involved in DNA repair
K04M3_RS20010	COG3040	lipid binding
K04M3_RS20020	COG1288	antiporter activity
K04M3_RS20030	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
K04M3_RS20045	COG2425	protein containing a von Willebrand factor type A (vWA) domain
K04M3_RS20060	COG0583	DNA-binding transcription factor activity
K04M3_RS20065	COG0277	FAD linked oxidase domain protein
K04M3_RS20080	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K04M3_RS20115	COG2176	DNA-directed DNA polymerase activity
K04M3_RS20160	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
K04M3_RS20165	COG1328	CTP reductase activity
K04M3_RS20365	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K04M3_RS20390	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K04M3_RS20395	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K04M3_RS20405	COG2116	formate transmembrane transporter activity
K04M3_RS20425	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
K04M3_RS20465	COG3118	belongs to the thioredoxin family
K04M3_RS20470	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K04M3_RS20495	COG2271	Major facilitator Superfamily
K04M3_RS20500	COG3851	Histidine kinase
K04M3_RS20505	COG2197	response regulator
K04M3_RS20515	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K04M3_RS20520	COG0583	DNA-binding transcription factor activity
K04M3_RS20530	COG0243	molybdopterin cofactor binding
K04M3_RS20545	COG0384	phenazine biosynthesis protein PhzF
K04M3_RS20550	COG1794	racemase activity, acting on amino acids and derivatives
K04M3_RS20580	COG1328	CTP reductase activity
K04M3_RS20585	COG0602	queuosine metabolic process
K04M3_RS20590	COG0534	Mate efflux family protein
K04M3_RS20595	COG2207	Transcriptional regulator
K04M3_RS20605	COG0189	ligase activity
K04M3_RS20605	COG4067	protein conserved in archaea
K04M3_RS20615	COG3111	PFAM Bacterial OB fold (BOF) protein
K04M3_RS20625	COG0725	ABC transporter, periplasmic molybdate-binding protein
K04M3_RS20630	COG4149	molybdate abc transporter
K04M3_RS20635	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
K04M3_RS20645	COG2203	Gaf domain
K04M3_RS20645	COG5001	Diguanylate cyclase
K04M3_RS20645	COG4251	negative regulation of phosphorylation
K04M3_RS20645	COG3706	GGDEF domain
K04M3_RS20665	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
K04M3_RS20670	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
K04M3_RS20695	COG3140	Belongs to the UPF0181 family
K04M3_RS20710	COG0583	DNA-binding transcription factor activity
K04M3_RS20870	COG4128	Pfam Zonular occludens toxin
K04M3_RS20935	COG4128	Pfam Zonular occludens toxin
K04M3_RS21005	COG0583	DNA-binding transcription factor activity
K04M3_RS21090	COG4128	Pfam Zonular occludens toxin
K04M3_RS21140	COG0023	Translation Initiation Factor
K04M3_RS21150	COG1181	Belongs to the D-alanine--D-alanine ligase family
K04M3_RS21165	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K04M3_RS21165	COG1042	CoA-binding domain protein
K04M3_RS21165	COG0045	succinate-CoA ligase (ADP-forming) activity
K04M3_RS21170	COG0583	DNA-binding transcription factor activity
K04M3_RS21185	COG5002	protein histidine kinase activity
K04M3_RS21185	COG3447	MASE1 domain protein
K04M3_RS21185	COG5001	Diguanylate cyclase
K04M3_RS21190	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
K04M3_RS21195	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
K04M3_RS21200	COG1984	allophanate hydrolase subunit 2
K04M3_RS21210	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
K04M3_RS21215	COG4181	ATPase activity
K04M3_RS21225	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K04M3_RS21230	COG5001	Diguanylate cyclase
K04M3_RS21230	COG3300	MHYT domain
K04M3_RS21265	COG4533	DNA binding
K04M3_RS21275	COG2050	protein possibly involved in aromatic compounds catabolism
K04M3_RS21290	COG2067	long-chain fatty acid transport protein
K04M3_RS21295	COG2267	carboxylic ester hydrolase activity
K04M3_RS21315	COG0861	Integral membrane protein TerC family
K04M3_RS21320	COG0737	Belongs to the 5'-nucleotidase family
K04M3_RS21325	COG3593	DNA synthesis involved in DNA repair
K04M3_RS21335	COG0583	DNA-binding transcription factor activity
K04M3_RS21340	COG2116	formate transmembrane transporter activity
K04M3_RS21345	COG2353	YceI-like domain
K04M3_RS21350	COG3038	cytochrome b561
K04M3_RS21370	COG0513	Belongs to the DEAD box helicase family
K04M3_RS21375	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
K04M3_RS21385	COG0840	transmembrane signaling receptor activity
K04M3_RS21395	COG0546	phosphoglycolate phosphatase activity
K04M3_RS21410	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K04M3_RS21415	COG2759	Belongs to the formate--tetrahydrofolate ligase family
K04M3_RS21420	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K04M3_RS21435	COG2207	Transcriptional regulator
K04M3_RS21440	COG1979	alcohol dehydrogenase
K04M3_RS21450	COG1126	abc transporter atp-binding protein
K04M3_RS21455	COG0765	amino acid transport
K04M3_RS21460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K04M3_RS21465	COG0765	amino acid transport
K04M3_RS21470	COG2200	EAL domain
K04M3_RS21470	COG2203	Gaf domain
K04M3_RS21470	COG2199	diguanylate cyclase activity
K04M3_RS21485	COG1609	Transcriptional regulator
K04M3_RS21490	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K04M3_RS21490	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K04M3_RS21495	COG1105	Belongs to the carbohydrate kinase PfkB family
K04M3_RS21500	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
K04M3_RS21500	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K04M3_RS21500	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K04M3_RS21530	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K04M3_RS21540	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K04M3_RS21545	COG0509	glycine decarboxylation via glycine cleavage system
K04M3_RS21555	COG0346	lactoylglutathione lyase activity
K04M3_RS21560	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K04M3_RS21565	COG0583	DNA-binding transcription factor activity
K04M3_RS21570	COG0697	spore germination
K04M3_RS21575	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K04M3_RS21605	COG2176	DNA-directed DNA polymerase activity
K04M3_RS21645	COG0242	peptide deformylase activity
K04M3_RS21680	COG2239	Acts as a magnesium transporter
K04M3_RS21700	COG0346	lactoylglutathione lyase activity
K04M3_RS21705	COG1902	pentaerythritol trinitrate reductase activity
K04M3_RS21715	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K04M3_RS21715	COG2755	lipolytic protein G-D-S-L family
K04M3_RS21725	COG5642	Protein of unknown function (DUF2384)
K04M3_RS21730	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
K04M3_RS21765	COG2076	Multidrug Resistance protein
K04M3_RS21785	COG2962	Rard protein
K04M3_RS21800	COG0784	Response regulator, receiver
K04M3_RS21800	COG0835	chemotaxis
K04M3_RS21810	COG2197	response regulator
K04M3_RS21820	COG3706	GGDEF domain
K04M3_RS21825	COG2197	response regulator
K04M3_RS21830	COG3300	MHYT domain
K04M3_RS21830	COG5001	Diguanylate cyclase
K04M3_RS21835	COG2205	protein histidine kinase activity
K04M3_RS21835	COG0784	Response regulator, receiver
K04M3_RS21840	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
K04M3_RS21860	COG0456	acetyltransferase
K04M3_RS21860	COG1214	PFAM Peptidase M22, glycoprotease
K04M3_RS21870	COG3069	C4-dicarboxylate transmembrane transporter activity
K04M3_RS21900	COG3111	PFAM Bacterial OB fold (BOF) protein
K04M3_RS21905	COG1597	lipid kinase activity
K04M3_RS21910	COG0583	DNA-binding transcription factor activity
K04M3_RS21915	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K04M3_RS21945	COG0714	Associated with various cellular activities
K04M3_RS21950	COG0641	radical SAM
K04M3_RS21955	COG3119	arylsulfatase activity
K04M3_RS21965	COG3119	arylsulfatase activity
K04M3_RS21970	COG0745	RESPONSE REGULATOR receiver
K04M3_RS21985	COG0784	Response regulator, receiver
K04M3_RS21985	COG2205	protein histidine kinase activity
K04M3_RS21985	COG2198	Histidine kinase
K04M3_RS21990	COG1879	ABC-type sugar transport system periplasmic component
K04M3_RS21995	COG1803	Methylglyoxal synthase
K04M3_RS22000	COG0210	DNA helicase
K04M3_RS22005	COG1289	transmembrane transporter activity
K04M3_RS22040	COG1629	transport
K04M3_RS22040	COG4771	TonB-dependent receptor
K04M3_RS22050	COG0789	Transcriptional regulator
K04M3_RS22055	COG4604	ABC transporter, ATP-binding protein
K04M3_RS22060	COG4605	iron ion homeostasis
K04M3_RS22065	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K04M3_RS22070	COG4607	ABC-type enterochelin transport system periplasmic component
K04M3_RS22080	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
K04M3_RS22095	COG1609	Transcriptional regulator
K04M3_RS22100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K04M3_RS22105	COG1879	ABC-type sugar transport system periplasmic component
K04M3_RS22110	COG1172	Belongs to the binding-protein-dependent transport system permease family
K04M3_RS22115	COG1129	ABC transporter
K04M3_RS22120	COG1869	D-ribose catabolic process
K04M3_RS22125	COG5001	Diguanylate cyclase
K04M3_RS22180	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K04M3_RS22190	COG2205	protein histidine kinase activity
K04M3_RS22190	COG0784	Response regulator, receiver
K04M3_RS22205	COG0330	HflC and HflK could
K04M3_RS22220	COG0517	IMP dehydrogenase activity
K04M3_RS22220	COG4175	Glycine betaine
K04M3_RS22225	COG4176	ABC-type proline glycine betaine transport system permease component
K04M3_RS22240	COG1012	belongs to the aldehyde dehydrogenase family
K04M3_RS22245	COG1309	transcriptional regulator
K04M3_RS22255	COG1028	Short-chain dehydrogenase reductase Sdr
K04M3_RS22270	COG1024	Enoyl-CoA hydratase
K04M3_RS22275	COG1960	acyl-CoA dehydrogenase activity
K04M3_RS22285	COG0183	Belongs to the thiolase family
K04M3_RS22295	COG1960	acyl-CoA dehydrogenase activity
K04M3_RS22300	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K04M3_RS22310	COG4770	biotin carboxylase activity
K04M3_RS22325	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K04M3_RS22325	COG3264	Mechanosensitive ion channel
K04M3_RS22330	COG0110	maltose O-acetyltransferase activity
K04M3_RS22335	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K04M3_RS22340	COG1271	oxidase subunit
K04M3_RS22345	COG1294	oxidase, subunit
K04M3_RS22355	COG0384	phenazine biosynthesis protein PhzF
K04M3_RS22375	COG3527	Alpha-acetolactate decarboxylase
K04M3_RS22385	COG1028	Short-chain dehydrogenase reductase Sdr
K04M3_RS22390	COG0500	methyltransferase
K04M3_RS22420	COG1022	Amp-dependent synthetase and ligase
K04M3_RS22450	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K04M3_RS22455	COG1263	PTS System
K04M3_RS22455	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K04M3_RS22460	COG1486	melibiose metabolic process
K04M3_RS22465	COG2188	Transcriptional regulator
K04M3_RS22470	COG1320	monovalent cation:proton antiporter activity
K04M3_RS22475	COG2212	antiporter activity
K04M3_RS22480	COG1863	multisubunit Na H antiporter MnhE subunit
K04M3_RS22485	COG0651	ATP synthesis coupled electron transport
K04M3_RS22490	COG1006	Multisubunit Na H antiporter MnhC subunit
K04M3_RS22495	COG2111	Na H antiporter
K04M3_RS22495	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K04M3_RS22505	COG0589	response to stress
K04M3_RS22510	COG4221	oxidoreductase activity
K04M3_RS22515	COG0583	DNA-binding transcription factor activity
K04M3_RS22525	COG2814	Major facilitator Superfamily
K04M3_RS22590	COG1522	sequence-specific DNA binding
K04M3_RS22625	COG0515	serine threonine protein kinase
K04M3_RS22650	COG3501	Rhs element vgr protein
K04M3_RS22665	COG2204	response regulator
K04M3_RS22690	COG0739	heme binding
K04M3_RS22705	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K04M3_RS22755	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
K04M3_RS22765	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
K04M3_RS22765	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
K04M3_RS22780	COG4989	oxidoreductase activity
K04M3_RS22795	COG0038	chloride channel
K04M3_RS22830	COG2897	thiosulfate sulfurtransferase activity
K04M3_RS22850	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K04M3_RS22855	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K04M3_RS22860	COG0840	transmembrane signaling receptor activity
K04M3_RS22865	COG2814	Major facilitator Superfamily
K04M3_RS22870	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K04M3_RS22885	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K04M3_RS22895	COG0840	transmembrane signaling receptor activity
K04M3_RS22915	COG2195	Cleaves the N-terminal amino acid of tripeptides
K04M3_RS22930	COG2197	response regulator
K04M3_RS22935	COG3850	Histidine kinase
K04M3_RS22940	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K04M3_RS22950	COG0243	molybdopterin cofactor binding
K04M3_RS22960	COG3005	denitrification pathway
K04M3_RS22970	COG3243	poly(R)-hydroxyalkanoic acid synthase
K04M3_RS22980	COG0183	Belongs to the thiolase family
K04M3_RS22990	COG1280	lysine exporter protein (LysE YggA)
K04M3_RS23000	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K04M3_RS23005	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K04M3_RS23060	COG1846	Transcriptional regulator
K04M3_RS23065	COG2205	protein histidine kinase activity
K04M3_RS23065	COG0784	Response regulator, receiver
K04M3_RS23070	COG1879	ABC-type sugar transport system periplasmic component
K04M3_RS23080	COG2827	Endonuclease containing a URI domain
K04M3_RS23085	COG3132	Protein of unknown function, DUF480
K04M3_RS23105	COG0784	Response regulator, receiver
K04M3_RS23105	COG2205	protein histidine kinase activity
K04M3_RS23105	COG5002	protein histidine kinase activity
K04M3_RS23130	COG0583	DNA-binding transcription factor activity
K04M3_RS23140	COG0531	amino acid
K04M3_RS23155	COG2205	protein histidine kinase activity
K04M3_RS23160	COG0745	RESPONSE REGULATOR receiver
K04M3_RS23190	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K04M3_RS23195	COG2239	Acts as a magnesium transporter
K04M3_RS23200	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
K04M3_RS23205	COG0402	S-adenosylhomocysteine deaminase activity
K04M3_RS23210	COG1418	mRNA catabolic process
K04M3_RS23220	COG2814	Major facilitator Superfamily
K04M3_RS23230	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K04M3_RS23250	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K04M3_RS23265	COG0745	RESPONSE REGULATOR receiver
K04M3_RS23270	COG2205	protein histidine kinase activity
K04M3_RS23280	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K04M3_RS23285	COG2194	sulfuric ester hydrolase activity
K04M3_RS23305	COG4667	esterase of the alpha-beta hydrolase superfamily
K04M3_RS23310	COG1741	Belongs to the pirin family
K04M3_RS23315	COG1278	Cold shock
K04M3_RS23330	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K04M3_RS23335	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K04M3_RS23335	COG0678	peroxiredoxin activity
K04M3_RS23345	COG1686	Belongs to the peptidase S11 family
K04M3_RS23355	COG0625	glutathione transferase activity
K04M3_RS23365	COG1621	beta-fructofuranosidase activity
K04M3_RS23370	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K04M3_RS23375	COG1263	PTS System
K04M3_RS23375	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K04M3_RS23395	COG1028	Short-chain dehydrogenase reductase Sdr
K04M3_RS23410	COG3746	phosphate-selective porin O and P
K04M3_RS23425	COG0300	oxidoreductase activity
K04M3_RS23430	COG0583	DNA-binding transcription factor activity
K04M3_RS23435	COG2207	Transcriptional regulator
K04M3_RS23435	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K04M3_RS23440	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K04M3_RS23465	COG0513	Belongs to the DEAD box helicase family
K04M3_RS23475	COG0583	DNA-binding transcription factor activity
K04M3_RS23490	COG1902	pentaerythritol trinitrate reductase activity
K04M3_RS23495	COG1063	alcohol dehydrogenase
K04M3_RS23505	COG1028	Short-chain dehydrogenase reductase Sdr
K04M3_RS23515	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K04M3_RS23520	COG0006	proline dipeptidase activity
K04M3_RS23525	COG3608	succinylglutamate desuccinylase aspartoacylase
K04M3_RS23530	COG1522	sequence-specific DNA binding
K04M3_RS23535	COG1012	belongs to the aldehyde dehydrogenase family
K04M3_RS23540	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K04M3_RS23545	COG3122	Protein conserved in bacteria
K04M3_RS23560	COG0583	DNA-binding transcription factor activity
K04M3_RS23565	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K04M3_RS23570	COG0252	asparaginase activity
K04M3_RS23575	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
K04M3_RS23590	COG2197	response regulator
K04M3_RS23595	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K04M3_RS23620	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K04M3_RS23650	COG3842	ATPase activity
K04M3_RS23670	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K04M3_RS23700	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K04M3_RS23705	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K04M3_RS23740	COG0583	DNA-binding transcription factor activity
K04M3_RS23750	COG4948	Mandelate Racemase Muconate Lactonizing
K04M3_RS23785	COG1342	Belongs to the UPF0251 family
K04M3_RS23790	COG4176	ABC-type proline glycine betaine transport system permease component
K04M3_RS23795	COG3448	diguanylate cyclase activity
K04M3_RS23795	COG4175	Glycine betaine
K04M3_RS23800	COG3015	lipoprotein NlpE involved in copper resistance
K04M3_RS23805	COG3713	MltA-interacting MipA family protein
K04M3_RS23820	COG0583	DNA-binding transcription factor activity
K04M3_RS23845	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
K04M3_RS23855	COG1335	isochorismatase
K04M3_RS23870	COG1349	DNA-binding transcription factor activity
K04M3_RS23880	COG2070	2-Nitropropane dioxygenase
K04M3_RS23885	COG0531	amino acid
K04M3_RS23890	COG4302	ethanolamine ammonia-lyase activity
K04M3_RS23895	COG4303	Ethanolamine ammonia lyase large subunit
K04M3_RS23905	COG1309	transcriptional regulator
K04M3_RS23925	COG1280	lysine exporter protein (LysE YggA)
K04M3_RS23935	COG0459	protein refolding
K04M3_RS23940	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
K04M3_RS23950	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K04M3_RS23965	COG1304	FMN binding
K04M3_RS23990	COG1256	bacterial-type flagellum assembly
K04M3_RS23990	COG4786	Flagellar basal body rod
K04M3_RS24000	COG1706	bacterial-type flagellum-dependent cell motility
K04M3_RS24005	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
K04M3_RS24010	COG4786	Flagellar basal body rod
K04M3_RS24015	COG4787	bacterial-type flagellum-dependent cell motility
K04M3_RS24030	COG1558	bacterial-type flagellum-dependent cell motility
K04M3_RS24035	COG1815	bacterial-type flagellum-dependent cell motility
K04M3_RS24055	COG0741	lytic transglycosylase activity
K04M3_RS24060	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K04M3_RS24080	COG1760	l-serine dehydratase
K04M3_RS24095	COG0583	DNA-binding transcription factor activity
K04M3_RS24105	COG2866	Carboxypeptidase
K04M3_RS24110	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K04M3_RS24120	COG2990	Protein conserved in bacteria
K04M3_RS24145	COG3842	ATPase activity
K04M3_RS24155	COG1840	ABC-type Fe3 transport system, periplasmic component
K04M3_RS24165	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K04M3_RS24175	COG1609	Transcriptional regulator
K04M3_RS24205	COG3240	lipase activity
K04M3_RS24210	COG1309	transcriptional regulator
K04M3_RS24225	COG1136	(ABC) transporter
K04M3_RS24225	COG0577	efflux transmembrane transporter activity
K04M3_RS24230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K04M3_RS24235	COG2067	long-chain fatty acid transport protein
K04M3_RS24245	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
K04M3_RS24260	COG1011	Hydrolase
K04M3_RS24300	COG0110	maltose O-acetyltransferase activity
K04M3_RS24305	COG1765	OsmC-like protein
K04M3_RS24310	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K04M3_RS24310	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K04M3_RS24325	COG3046	protein related to deoxyribodipyrimidine photolyase
K04M3_RS24330	COG0415	Belongs to the DNA photolyase family
K04M3_RS24335	COG3706	GGDEF domain
K04M3_RS24350	COG3706	GGDEF domain
K04M3_RS24365	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K04M3_RS24385	COG3033	Beta-eliminating lyase
K04M3_RS24395	COG1271	oxidase subunit
K04M3_RS24400	COG1294	oxidase, subunit
K04M3_RS24420	COG3179	chitinase
K04M3_RS24425	COG0579	oxidoreductase
K04M3_RS24445	COG3706	GGDEF domain
K04M3_RS24480	COG0583	DNA-binding transcription factor activity
K04M3_RS24505	COG0189	ligase activity
K04M3_RS24510	COG4067	protein conserved in archaea
K04M3_RS24510	COG0189	ligase activity
K04M3_RS24520	COG1166	arginine decarboxylase activity
K04M3_RS24525	COG0010	Belongs to the arginase family
K04M3_RS24530	COG2814	Major facilitator Superfamily
K04M3_RS24535	COG1770	oligopeptidase
K04M3_RS24550	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K04M3_RS24555	COG1121	(ABC) transporter
K04M3_RS24560	COG0803	Belongs to the bacterial solute-binding protein 9 family
K04M3_RS24600	COG0848	biopolymer transport protein
K04M3_RS24605	COG0811	peptide transport
K04M3_RS24610	COG0811	peptide transport
K04M3_RS24630	COG0745	RESPONSE REGULATOR receiver
K04M3_RS24635	COG0584	glycerophosphoryl diester phosphodiesterase
K04M3_RS24645	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K04M3_RS24710	COG0312	modulator of DNA gyrase
K04M3_RS24715	COG0312	modulator of DNA gyrase
K04M3_RS24720	COG0351	phosphomethylpyrimidine kinase
K04M3_RS24725	COG1116	anion transmembrane transporter activity
K04M3_RS24730	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K04M3_RS24735	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K04M3_RS24740	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
K04M3_RS24760	COG0243	molybdopterin cofactor binding
K04M3_RS24765	COG3005	denitrification pathway
K04M3_RS24770	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K04M3_RS24775	COG1028	Short-chain dehydrogenase reductase Sdr
K04M3_RS24790	COG0456	acetyltransferase
K04M3_RS24810	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K04M3_RS24815	COG1929	Belongs to the glycerate kinase type-1 family
K04M3_RS24820	COG2610	gluconate transmembrane transporter activity
K04M3_RS24825	COG3835	regulator
K04M3_RS24885	COG3047	cAMP biosynthetic process
K04M3_RS24890	COG1357	PFAM Pentapeptide repeats (8 copies)
K04M3_RS24920	COG2375	cellular response to nickel ion
K04M3_RS24925	COG0583	DNA-binding transcription factor activity
K04M3_RS24930	COG2162	N-hydroxyarylamine O-acetyltransferase activity
K04M3_RS24935	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
K04M3_RS24950	COG2199	diguanylate cyclase activity
K04M3_RS24960	COG0561	phosphatase activity
K04M3_RS24965	COG0583	DNA-binding transcription factor activity
K04M3_RS24980	COG0564	pseudouridine synthase activity
K04M3_RS24985	COG0534	Mate efflux family protein
K04M3_RS25000	COG3123	guanosine phosphorylase activity
K04M3_RS25015	COG0596	Alpha beta hydrolase
K04M3_RS25040	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K04M3_RS25050	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K04M3_RS25055	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K04M3_RS25055	COG2169	Transcriptional regulator
K04M3_RS25065	COG2259	Doxx family
K04M3_RS25070	COG1741	Belongs to the pirin family
K04M3_RS25090	COG0363	glucosamine-6-phosphate deaminase activity
K04M3_RS25100	COG0786	glutamate:sodium symporter activity
K04M3_RS25105	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K04M3_RS25110	COG1131	(ABC) transporter
K04M3_RS25120	COG0786	glutamate:sodium symporter activity
K04M3_RS25145	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K04M3_RS25155	COG3279	Response regulator of the LytR AlgR family
K04M3_RS25160	COG3275	phosphorelay sensor kinase activity
K04M3_RS25190	COG0772	Belongs to the SEDS family
K04M3_RS25215	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K04M3_RS25215	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
K04M3_RS25225	COG0444	Belongs to the ABC transporter superfamily
K04M3_RS25230	COG4608	Belongs to the ABC transporter superfamily
K04M3_RS25675	COG0358	DNA primase activity
K04M3_RS25785	COG0358	DNA primase activity
K04M3_RS25985	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K04M3_RS26170	COG2916	Histone family protein nucleoid-structuring protein H-NS
K04M3_RS26440	COG0330	HflC and HflK could
K04M3_RS26445	COG0330	HflC and HflK could
K04M3_RS26490	COG2203	Gaf domain
K04M3_RS26490	COG3706	GGDEF domain
K04M3_RS26490	COG4251	negative regulation of phosphorylation
K04M3_RS26490	COG5001	Diguanylate cyclase
K04M3_RS26600	COG0358	DNA primase activity