locus-tag	class	description
K05K4_RS00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K05K4_RS00015	COG0592	DNA-directed DNA polymerase activity
K05K4_RS00025	COG0187	DNA topoisomerase II activity
K05K4_RS00045	COG0071	Belongs to the small heat shock protein (HSP20) family
K05K4_RS00050	COG3977	Valine--pyruvate aminotransferase
K05K4_RS00055	COG0366	Alpha amylase catalytic
K05K4_RS00070	COG2119	membrane
K05K4_RS00080	COG0425	Belongs to the sulfur carrier protein TusA family
K05K4_RS00095	COG0604	alcohol dehydrogenase
K05K4_RS00100	COG0183	Belongs to the thiolase family
K05K4_RS00110	COG1739	Uncharacterized protein family UPF0029
K05K4_RS00115	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K05K4_RS00155	COG0583	DNA-binding transcription factor activity
K05K4_RS00160	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K05K4_RS00165	COG2960	long-chain fatty acid transporting porin activity
K05K4_RS00170	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K05K4_RS00175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K05K4_RS00235	COG4166	transmembrane transport
K05K4_RS00240	COG0601	transmembrane transport
K05K4_RS00245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K05K4_RS00260	COG1609	Transcriptional regulator
K05K4_RS00265	COG0583	DNA-binding transcription factor activity
K05K4_RS00280	COG0129	dihydroxy-acid dehydratase activity
K05K4_RS00285	COG3265	gluconokinase activity
K05K4_RS00290	COG2610	gluconate transmembrane transporter activity
K05K4_RS00295	COG0800	Aldolase
K05K4_RS00300	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
K05K4_RS00305	COG0583	DNA-binding transcription factor activity
K05K4_RS00310	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K05K4_RS00315	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
K05K4_RS00325	COG1522	sequence-specific DNA binding
K05K4_RS00330	COG5002	protein histidine kinase activity
K05K4_RS00330	COG5001	Diguanylate cyclase
K05K4_RS00335	COG0742	ribosomal rna small subunit methyltransferase
K05K4_RS00350	COG0589	response to stress
K05K4_RS00355	COG1528	Iron-storage protein
K05K4_RS00365	COG2081	HI0933 family
K05K4_RS00395	COG1597	lipid kinase activity
K05K4_RS00425	COG0628	permease
K05K4_RS00440	COG1322	Protein conserved in bacteria
K05K4_RS00445	COG2226	methyltransferase
K05K4_RS00450	COG3165	ubiquinone biosynthetic process from chorismate
K05K4_RS00455	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K05K4_RS00465	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K05K4_RS00470	COG0805	protein transport
K05K4_RS00480	COG0084	hydrolase, TatD family'
K05K4_RS00495	COG0456	acetyltransferase
K05K4_RS00505	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K05K4_RS00505	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K05K4_RS00510	COG0218	Necessary for normal cell division and for the maintenance of normal septation
K05K4_RS00545	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K05K4_RS00555	COG2204	response regulator
K05K4_RS00560	COG3852	Histidine kinase
K05K4_RS00570	COG0174	glutamine synthetase
K05K4_RS00575	COG1217	gtp-binding protein TYPA
K05K4_RS00580	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K05K4_RS00590	COG1295	ribonuclease BN
K05K4_RS00595	COG1490	D-aminoacyl-tRNA deacylase activity
K05K4_RS00600	COG0456	acetyltransferase
K05K4_RS00610	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
K05K4_RS00615	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
K05K4_RS00620	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
K05K4_RS00625	COG3031	protein transport across the cell outer membrane
K05K4_RS00635	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K05K4_RS00640	COG1459	type II secretion system
K05K4_RS00645	COG2165	general secretion pathway protein
K05K4_RS00650	COG2165	general secretion pathway protein
K05K4_RS00655	COG2165	general secretion pathway protein
K05K4_RS00660	COG4795	General secretion pathway protein
K05K4_RS00665	COG3156	type II secretion system protein K
K05K4_RS00670	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
K05K4_RS00675	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
K05K4_RS00685	COG1218	3'(2'),5'-bisphosphate nucleotidase
K05K4_RS00690	COG0494	nUDIX hydrolase
K05K4_RS00700	COG1040	competence protein
K05K4_RS00715	COG2183	response to ionizing radiation
K05K4_RS00725	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K05K4_RS00745	COG2233	PERMEase
K05K4_RS00750	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K05K4_RS00755	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K05K4_RS00760	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K05K4_RS00765	COG1758	RNA polymerase activity
K05K4_RS00770	COG0194	GDP metabolic process
K05K4_RS00790	COG0848	biopolymer transport protein
K05K4_RS00795	COG0811	peptide transport
K05K4_RS00820	COG4174	ABC transporter (Permease)
K05K4_RS00825	COG4239	(ABC) transporter, permease
K05K4_RS00830	COG0747	negative chemotaxis
K05K4_RS00835	COG0444	Belongs to the ABC transporter superfamily
K05K4_RS00840	COG4608	Belongs to the ABC transporter superfamily
K05K4_RS00850	COG1561	YicC-like family, N-terminal region
K05K4_RS00860	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
K05K4_RS00865	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K05K4_RS00870	COG1560	Kdo2-lipid A biosynthetic process
K05K4_RS00875	COG1309	transcriptional regulator
K05K4_RS00880	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K05K4_RS00895	COG2003	Belongs to the UPF0758 family
K05K4_RS00920	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K05K4_RS00935	COG0463	Glycosyl transferase, family 2
K05K4_RS00940	COG0859	PFAM glycosyl transferase family 9
K05K4_RS00945	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K05K4_RS00950	COG3642	lipopolysaccharide core region biosynthetic process
K05K4_RS00960	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
K05K4_RS01000	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K05K4_RS01005	COG1519	Transferase
K05K4_RS01010	COG0859	PFAM glycosyl transferase family 9
K05K4_RS01020	COG1560	Kdo2-lipid A biosynthetic process
K05K4_RS01040	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K05K4_RS01090	COG0438	transferase activity, transferring glycosyl groups
K05K4_RS01100	COG0297	glycogen (starch) synthase activity
K05K4_RS01100	COG0438	transferase activity, transferring glycosyl groups
K05K4_RS01110	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K05K4_RS01115	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
K05K4_RS01120	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K05K4_RS01155	COG1215	transferase activity, transferring glycosyl groups
K05K4_RS01180	COG0149	triose-phosphate isomerase activity
K05K4_RS01210	COG1494	fructose-1,6-bisphosphatase
K05K4_RS01225	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K05K4_RS01230	COG1575	Belongs to the MenA family. Type 1 subfamily
K05K4_RS01260	COG2003	Belongs to the UPF0758 family
K05K4_RS01275	COG4565	transcriptional regulatory protein
K05K4_RS01285	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
K05K4_RS01290	COG0511	ligase activity, forming carbon-carbon bonds
K05K4_RS01290	COG5016	pyruvate
K05K4_RS01295	COG3630	sodium ion export across plasma membrane
K05K4_RS01305	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
K05K4_RS01315	COG2301	Belongs to the HpcH HpaI aldolase family
K05K4_RS01320	COG3051	citrate lyase alpha subunit
K05K4_RS01330	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
K05K4_RS01345	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K05K4_RS01350	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
K05K4_RS01360	COG1609	Transcriptional regulator
K05K4_RS01365	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K05K4_RS01375	COG0254	rRNA binding
K05K4_RS01385	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K05K4_RS01390	COG0088	Forms part of the polypeptide exit tunnel
K05K4_RS01400	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K05K4_RS01405	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K05K4_RS01410	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K05K4_RS01415	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K05K4_RS01425	COG0255	Belongs to the universal ribosomal protein uL29 family
K05K4_RS01430	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K05K4_RS01440	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K05K4_RS01445	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K05K4_RS01450	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K05K4_RS01455	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K05K4_RS01460	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K05K4_RS01475	COG1841	ribosomal large subunit assembly
K05K4_RS01480	COG0200	Binds to the 23S rRNA
K05K4_RS01485	COG0201	protein transport
K05K4_RS01490	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K05K4_RS01495	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K05K4_RS01500	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K05K4_RS01510	COG0202	RNA polymerase activity
K05K4_RS01515	COG0203	ribosomal protein L17
K05K4_RS01525	COG0545	Peptidyl-prolyl cis-trans isomerase
K05K4_RS01535	COG2153	protein acetylation
K05K4_RS01540	COG0513	Belongs to the DEAD box helicase family
K05K4_RS01555	COG1648	precorrin-2 dehydrogenase activity
K05K4_RS01555	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K05K4_RS01560	COG0175	sulfate reduction
K05K4_RS01565	COG2895	sulfate adenylyltransferase (ATP) activity
K05K4_RS01570	COG0471	metal ion transport
K05K4_RS01570	COG3273	potassium ion transport
K05K4_RS01575	COG0529	Catalyzes the synthesis of activated sulfate
K05K4_RS01595	COG4181	ATPase activity
K05K4_RS01610	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
K05K4_RS01620	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K05K4_RS01625	COG0729	surface antigen
K05K4_RS01630	COG2911	Protein conserved in bacteria
K05K4_RS01635	COG2105	PFAM AIG2 family protein
K05K4_RS01645	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
K05K4_RS01650	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
K05K4_RS01660	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K05K4_RS01665	COG0163	prenyltransferase activity
K05K4_RS01670	COG4143	(ABC) transporter
K05K4_RS01675	COG1178	ABC-type Fe3 transport system permease component
K05K4_RS01680	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
K05K4_RS01685	COG0583	DNA-binding transcription factor activity
K05K4_RS01690	COG1902	pentaerythritol trinitrate reductase activity
K05K4_RS01710	COG2358	TRAP transporter, solute receptor (TAXI family
K05K4_RS01735	COG0142	geranyltranstransferase activity
K05K4_RS01740	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K05K4_RS01750	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K05K4_RS01755	COG2966	Psort location CytoplasmicMembrane, score
K05K4_RS01765	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
K05K4_RS01770	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
K05K4_RS01775	COG2967	ApaG domain
K05K4_RS01780	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K05K4_RS01785	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
K05K4_RS01790	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K05K4_RS01795	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
K05K4_RS01800	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
K05K4_RS01820	COG0473	3-isopropylmalate dehydrogenase activity
K05K4_RS01825	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K05K4_RS01850	COG0583	DNA-binding transcription factor activity
K05K4_RS01855	COG1022	Amp-dependent synthetase and ligase
K05K4_RS01860	COG0028	Belongs to the TPP enzyme family
K05K4_RS01865	COG0440	acetolactate synthase activity
K05K4_RS01880	COG0469	pyruvate kinase activity
K05K4_RS01885	COG1349	DNA-binding transcription factor activity
K05K4_RS01890	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K05K4_RS01900	COG2376	Dihydroxyacetone kinase
K05K4_RS01905	COG1461	Dihydroxyacetone kinase
K05K4_RS01920	COG3722	fumarate hydratase activity
K05K4_RS01930	COG2213	PTS system mannitol-specific
K05K4_RS01930	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K05K4_RS01965	COG0358	DNA primase activity
K05K4_RS01970	COG1610	YqeY-like protein
K05K4_RS01975	COG0828	Belongs to the bacterial ribosomal protein bS21 family
K05K4_RS01980	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K05K4_RS01985	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K05K4_RS01990	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
K05K4_RS01995	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
K05K4_RS02000	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K05K4_RS02005	COG1968	undecaprenyl-diphosphatase activity
K05K4_RS02015	COG3409	Peptidoglycan-binding domain 1 protein
K05K4_RS02015	COG3267	Type II secretory pathway component ExeA
K05K4_RS02025	COG0405	Gamma-glutamyltransferase
K05K4_RS02030	COG4991	sh3 domain protein
K05K4_RS02035	COG0306	phosphate transporter
K05K4_RS02040	COG1392	Phosphate transport regulator
K05K4_RS02045	COG3025	triphosphatase activity
K05K4_RS02060	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
K05K4_RS02065	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
K05K4_RS02065	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
K05K4_RS02070	COG1538	Outer membrane efflux protein
K05K4_RS02075	COG0494	nUDIX hydrolase
K05K4_RS02080	COG3151	Protein conserved in bacteria
K05K4_RS02090	COG3150	esterase
K05K4_RS02100	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K05K4_RS02105	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K05K4_RS02115	COG3105	Protein conserved in bacteria
K05K4_RS02125	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
K05K4_RS02140	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K05K4_RS02145	COG0723	plastoquinol--plastocyanin reductase activity
K05K4_RS02150	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K05K4_RS02155	COG2857	Cytochrome c1
K05K4_RS02160	COG0625	glutathione transferase activity
K05K4_RS02165	COG2969	positive regulation of protein catabolic process
K05K4_RS02175	COG2823	Periplasmic or secreted lipoprotein
K05K4_RS02180	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
K05K4_RS02195	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
K05K4_RS02215	COG3116	cell division
K05K4_RS02220	COG0768	penicillin binding
K05K4_RS02225	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K05K4_RS02230	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K05K4_RS02235	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K05K4_RS02260	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K05K4_RS02285	COG3116	cell division
K05K4_RS02295	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K05K4_RS02300	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K05K4_RS02305	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K05K4_RS02310	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K05K4_RS02315	COG0772	Belongs to the SEDS family
K05K4_RS02330	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K05K4_RS02335	COG0849	cell division
K05K4_RS02340	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K05K4_RS02345	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
K05K4_RS02355	COG0653	protein targeting
K05K4_RS02360	COG0494	nUDIX hydrolase
K05K4_RS02370	COG0505	Belongs to the CarA family
K05K4_RS02375	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K05K4_RS02390	COG0730	response to heat
K05K4_RS02395	COG0583	DNA-binding transcription factor activity
K05K4_RS02400	COG2860	membrane
K05K4_RS02415	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K05K4_RS02425	COG0493	'glutamate synthase
K05K4_RS02430	COG0067	glutamate synthase
K05K4_RS02430	COG0069	glutamate synthase activity
K05K4_RS02430	COG0070	glutamate synthase
K05K4_RS02440	COG0067	glutamate synthase
K05K4_RS02440	COG0069	glutamate synthase activity
K05K4_RS02440	COG0070	glutamate synthase
K05K4_RS02445	COG1242	4 iron, 4 sulfur cluster binding
K05K4_RS02450	COG4251	negative regulation of phosphorylation
K05K4_RS02450	COG5001	Diguanylate cyclase
K05K4_RS02450	COG3706	GGDEF domain
K05K4_RS02450	COG2203	Gaf domain
K05K4_RS02455	COG5002	protein histidine kinase activity
K05K4_RS02455	COG0784	Response regulator, receiver
K05K4_RS02455	COG2198	Histidine kinase
K05K4_RS02465	COG0745	RESPONSE REGULATOR receiver
K05K4_RS02480	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K05K4_RS02500	COG0083	homoserine kinase activity
K05K4_RS02505	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
K05K4_RS02515	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
K05K4_RS02520	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
K05K4_RS02545	COG1115	amino acid carrier protein
K05K4_RS02550	COG3022	response to hydroperoxide
K05K4_RS02555	COG0513	Belongs to the DEAD box helicase family
K05K4_RS02560	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
K05K4_RS02570	COG0716	FMN binding
K05K4_RS02575	COG4974	Belongs to the 'phage' integrase family
K05K4_RS02580	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K05K4_RS02585	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K05K4_RS02600	COG2204	response regulator
K05K4_RS02610	COG0667	Aldo Keto reductase
K05K4_RS02635	COG0730	response to heat
K05K4_RS02640	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K05K4_RS02645	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
K05K4_RS02655	COG1283	sodium-dependent phosphate transmembrane transporter activity
K05K4_RS02660	COG0583	DNA-binding transcription factor activity
K05K4_RS02665	COG0640	Transcriptional regulator
K05K4_RS02670	COG0268	Binds directly to 16S ribosomal RNA
K05K4_RS02675	COG0728	peptidoglycan biosynthetic process
K05K4_RS02680	COG0196	riboflavin kinase activity
K05K4_RS02695	COG1047	Peptidyl-prolyl cis-trans
K05K4_RS02700	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K05K4_RS02710	COG3279	Response regulator of the LytR AlgR family
K05K4_RS02715	COG3275	phosphorelay sensor kinase activity
K05K4_RS02720	COG1966	Carbon starvation protein
K05K4_RS02740	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
K05K4_RS02745	COG1472	Belongs to the glycosyl hydrolase 3 family
K05K4_RS02750	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K05K4_RS02755	COG0287	Prephenate dehydrogenase
K05K4_RS02755	COG1605	Chorismate mutase
K05K4_RS02760	COG0739	heme binding
K05K4_RS02770	COG0488	(ABC) transporter
K05K4_RS02780	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
K05K4_RS02785	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
K05K4_RS02790	COG1605	Chorismate mutase
K05K4_RS02790	COG0077	Prephenate dehydratase
K05K4_RS02795	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K05K4_RS02805	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K05K4_RS02810	COG0564	pseudouridine synthase activity
K05K4_RS02820	COG0542	response to heat
K05K4_RS02885	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K05K4_RS02890	COG0826	peptidase U32
K05K4_RS02895	COG2974	May be involved in recombination
K05K4_RS02905	COG0745	RESPONSE REGULATOR receiver
K05K4_RS02910	COG5002	protein histidine kinase activity
K05K4_RS02920	COG0248	Ppx GppA phosphatase
K05K4_RS02925	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K05K4_RS02930	COG0573	inorganic phosphate transmembrane transporter activity
K05K4_RS02940	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K05K4_RS02945	COG0704	Plays a role in the regulation of phosphate uptake
K05K4_RS02955	COG3142	Participates in the control of copper homeostasis
K05K4_RS02960	COG0450	alkyl hydroperoxide reductase
K05K4_RS02965	COG0583	DNA-binding transcription factor activity
K05K4_RS02970	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
K05K4_RS02980	COG0517	IMP dehydrogenase activity
K05K4_RS02990	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K05K4_RS03000	COG1862	Preprotein translocase
K05K4_RS03005	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K05K4_RS03010	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K05K4_RS03025	COG0483	inositol monophosphate 1-phosphatase activity
K05K4_RS03030	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
K05K4_RS03040	COG1104	cysteine desulfurase activity
K05K4_RS03045	COG0822	iron-sulfur transferase activity
K05K4_RS03060	COG0443	Heat shock 70 kDa protein
K05K4_RS03065	COG0633	Ferredoxin
K05K4_RS03070	COG2975	iron-sulfur cluster assembly
K05K4_RS03080	COG0105	UTP biosynthetic process
K05K4_RS03095	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K05K4_RS03100	COG0124	histidyl-tRNA synthetase
K05K4_RS03105	COG2976	Protein conserved in bacteria
K05K4_RS03110	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K05K4_RS03115	COG1160	GTP binding
K05K4_RS03135	COG0517	IMP dehydrogenase activity
K05K4_RS03135	COG0516	GMP reductase activity
K05K4_RS03145	COG0582	viral genome integration into host DNA
K05K4_RS03215	COG1757	Na H antiporter
K05K4_RS03225	COG1584	GPR1 FUN34 yaaH family protein
K05K4_RS03230	COG1115	amino acid carrier protein
K05K4_RS03245	COG2873	o-acetylhomoserine
K05K4_RS03250	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K05K4_RS03270	COG3153	acetyltransferase
K05K4_RS03270	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K05K4_RS03275	COG0583	DNA-binding transcription factor activity
K05K4_RS03300	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K05K4_RS03305	COG2867	negative regulation of translational initiation
K05K4_RS03310	COG2914	Belongs to the UPF0125 (RnfH) family
K05K4_RS03315	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K05K4_RS03325	COG0497	DNA recombination
K05K4_RS03335	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K05K4_RS03340	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K05K4_RS03345	COG1301	dicarboxylic acid transport
K05K4_RS03355	COG0484	heat shock protein binding
K05K4_RS03390	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
K05K4_RS03405	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
K05K4_RS03410	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K05K4_RS03410	COG0047	phosphoribosylformylglycinamidine synthase activity
K05K4_RS03440	COG2195	Cleaves the N-terminal amino acid of tripeptides
K05K4_RS03445	COG2252	PERMEase
K05K4_RS03450	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
K05K4_RS03455	COG1073	alpha beta
K05K4_RS03465	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K05K4_RS03470	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K05K4_RS03475	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K05K4_RS03480	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K05K4_RS03480	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K05K4_RS03495	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
K05K4_RS03505	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
K05K4_RS03510	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
K05K4_RS03515	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K05K4_RS03520	COG0142	geranyltranstransferase activity
K05K4_RS03525	COG1722	exodeoxyribonuclease VII activity
K05K4_RS03530	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K05K4_RS03540	COG0301	tRNA thio-modification
K05K4_RS03540	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K05K4_RS03545	COG0583	DNA-binding transcription factor activity
K05K4_RS03555	COG2363	Small membrane protein
K05K4_RS03565	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K05K4_RS03570	COG1611	Belongs to the LOG family
K05K4_RS03585	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K05K4_RS03585	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K05K4_RS03595	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
K05K4_RS03600	COG1464	Belongs to the NlpA lipoprotein family
K05K4_RS03605	COG2011	ABC-type metal ion transport system permease component
K05K4_RS03610	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K05K4_RS03620	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
K05K4_RS03630	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K05K4_RS03630	COG1263	PTS System
K05K4_RS03635	COG0366	Alpha amylase catalytic
K05K4_RS03650	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K05K4_RS03655	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K05K4_RS03660	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K05K4_RS03665	COG0321	lipoyl(octanoyl) transferase activity
K05K4_RS03675	COG1686	Belongs to the peptidase S11 family
K05K4_RS03680	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
K05K4_RS03685	COG0772	Belongs to the SEDS family
K05K4_RS03690	COG0768	penicillin binding
K05K4_RS03695	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K05K4_RS03700	COG0799	negative regulation of ribosome biogenesis
K05K4_RS03705	COG1466	dna polymerase III delta subunit
K05K4_RS03710	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
K05K4_RS03715	COG0495	leucyl-tRNA aminoacylation
K05K4_RS03720	COG2888	peptidyl-tyrosine sulfation
K05K4_RS03725	COG0815	Transfers the fatty acyl group on membrane lipoproteins
K05K4_RS03730	COG4535	Mg2 and Co2 transporter CorC
K05K4_RS03735	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K05K4_RS03740	COG1702	phosphate starvation-inducible protein PhoH
K05K4_RS03745	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K05K4_RS03755	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K05K4_RS03865	COG0012	GTP binding
K05K4_RS03870	COG0193	aminoacyl-tRNA hydrolase activity
K05K4_RS03875	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K05K4_RS03880	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K05K4_RS03885	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
K05K4_RS03890	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
K05K4_RS03900	COG2890	protein-(glutamine-N5) methyltransferase activity
K05K4_RS03905	COG3094	Invasion gene expression up-regulator, SirB
K05K4_RS03910	COG2912	Transglutaminase-like superfamily
K05K4_RS03915	COG2877	3-deoxy-8-phosphooctulonate synthase activity
K05K4_RS03920	COG0737	Belongs to the 5'-nucleotidase family
K05K4_RS03925	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K05K4_RS03930	COG1187	pseudouridine synthase activity
K05K4_RS03935	COG2840	Smr protein MutS2
K05K4_RS03975	COG2217	Heavy metal translocating P-type atpase
K05K4_RS03975	COG2608	mercury ion transmembrane transporter activity
K05K4_RS03990	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
K05K4_RS04045	COG0835	chemotaxis
K05K4_RS04045	COG0784	Response regulator, receiver
K05K4_RS04050	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
K05K4_RS04055	COG1815	bacterial-type flagellum-dependent cell motility
K05K4_RS04060	COG1558	bacterial-type flagellum-dependent cell motility
K05K4_RS04070	COG1749	Flagellar hook protein flgE
K05K4_RS04075	COG4787	bacterial-type flagellum-dependent cell motility
K05K4_RS04085	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
K05K4_RS04090	COG1706	bacterial-type flagellum-dependent cell motility
K05K4_RS04095	COG1705	Flagellar rod assembly protein muramidase FlgJ
K05K4_RS04095	COG3951	Flagellar rod assembly protein muramidase FlgJ
K05K4_RS04105	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K05K4_RS04110	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K05K4_RS04115	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K05K4_RS04120	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K05K4_RS04125	COG2190	(PTS) system
K05K4_RS04130	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K05K4_RS04135	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K05K4_RS04145	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K05K4_RS04150	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
K05K4_RS04155	COG3115	cell septum assembly
K05K4_RS04160	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K05K4_RS04180	COG0330	HflC and HflK could
K05K4_RS04185	COG2194	sulfuric ester hydrolase activity
K05K4_RS04200	COG1192	Involved in chromosome partitioning
K05K4_RS04205	COG1215	transferase activity, transferring glycosyl groups
K05K4_RS04215	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
K05K4_RS04220	COG0457	Tetratricopeptide repeat
K05K4_RS04220	COG3118	belongs to the thioredoxin family
K05K4_RS04225	COG3118	belongs to the thioredoxin family
K05K4_RS04235	COG0300	oxidoreductase activity
K05K4_RS04240	COG1090	epimerase
K05K4_RS04270	COG0622	Phosphoesterase
K05K4_RS04290	COG3710	Transcriptional regulator
K05K4_RS04295	COG0326	Molecular chaperone. Has ATPase activity
K05K4_RS04305	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
K05K4_RS04310	COG3104	oligopeptide transport
K05K4_RS04315	COG0250	Participates in transcription elongation, termination and antitermination
K05K4_RS04320	COG0367	asparagine synthase
K05K4_RS04325	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K05K4_RS04325	COG4651	solute:proton antiporter activity
K05K4_RS04330	COG1940	carbohydrate kinase activity
K05K4_RS04330	COG1846	Transcriptional regulator
K05K4_RS04335	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K05K4_RS04345	COG1263	PTS System
K05K4_RS04345	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K05K4_RS04345	COG2190	(PTS) system
K05K4_RS04350	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K05K4_RS04355	COG0735	belongs to the Fur family
K05K4_RS04365	COG0716	FMN binding
K05K4_RS04375	COG0596	Alpha beta hydrolase
K05K4_RS04380	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
K05K4_RS04385	COG0033	Phosphoglucomutase
K05K4_RS04395	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
K05K4_RS04410	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
K05K4_RS04415	COG1053	succinate dehydrogenase
K05K4_RS04420	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K05K4_RS04425	COG0567	Dehydrogenase, E1 component
K05K4_RS04430	COG0508	dehydrogenase complex catalyzes the overall conversion of
K05K4_RS04435	COG0045	succinate-CoA ligase (ADP-forming) activity
K05K4_RS04445	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K05K4_RS04450	COG1121	(ABC) transporter
K05K4_RS04455	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
K05K4_RS04460	COG4977	sequence-specific DNA binding
K05K4_RS04465	COG1918	ferrous iron import across plasma membrane
K05K4_RS04490	COG0018	arginyl-trna synthetase
K05K4_RS04500	COG3102	Protein conserved in bacteria
K05K4_RS04515	COG0788	formyltetrahydrofolate deformylase activity
K05K4_RS04520	COG1199	ATP-dependent helicase activity
K05K4_RS04525	COG1214	PFAM Peptidase M22, glycoprotease
K05K4_RS04535	COG3065	identical protein binding
K05K4_RS04540	COG2267	carboxylic ester hydrolase activity
K05K4_RS04545	COG0318	PFAM AMP-dependent synthetase and ligase
K05K4_RS04550	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
K05K4_RS04555	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
K05K4_RS04560	COG2894	cell division
K05K4_RS04565	COG0850	regulation of cytokinetic process
K05K4_RS04570	COG3100	YcgL domain-containing protein
K05K4_RS04575	COG2951	lytic endotransglycosylase activity
K05K4_RS04585	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K05K4_RS04590	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K05K4_RS04600	COG2226	methyltransferase
K05K4_RS04610	COG1028	Short-chain dehydrogenase reductase Sdr
K05K4_RS04620	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K05K4_RS04645	COG2986	histidine ammonia-lyase
K05K4_RS04650	COG1216	Glycosyl transferase, family 2
K05K4_RS04655	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K05K4_RS04670	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K05K4_RS04675	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K05K4_RS04710	COG0513	Belongs to the DEAD box helicase family
K05K4_RS04715	COG0569	domain protein
K05K4_RS04720	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K05K4_RS04735	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
K05K4_RS04740	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K05K4_RS04745	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K05K4_RS04750	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K05K4_RS04775	COG0544	peptidyl-prolyl cis-trans isomerase activity
K05K4_RS04785	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K05K4_RS04790	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K05K4_RS04795	COG0776	regulation of translation
K05K4_RS04800	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K05K4_RS04805	COG1555	photosystem II stabilization
K05K4_RS04820	COG0232	Belongs to the dGTPase family. Type 2 subfamily
K05K4_RS04825	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
K05K4_RS04830	COG0436	Aminotransferase
K05K4_RS04835	COG1169	isochorismate synthase
K05K4_RS04840	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
K05K4_RS04850	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
K05K4_RS04870	COG2855	membrane
K05K4_RS04875	COG0477	Major facilitator Superfamily
K05K4_RS04920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K05K4_RS04925	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K05K4_RS04940	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K05K4_RS04945	COG1522	sequence-specific DNA binding
K05K4_RS04955	COG1946	Acyl-CoA thioesterase
K05K4_RS04960	COG3126	Type III secretion system lipoprotein chaperone (YscW)
K05K4_RS04985	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K05K4_RS04990	COG0516	GMP reductase activity
K05K4_RS04990	COG0517	IMP dehydrogenase activity
K05K4_RS05015	COG0537	adenosine 5'-monophosphoramidase activity
K05K4_RS05040	COG3150	esterase
K05K4_RS05045	COG1252	NADH dehydrogenase
K05K4_RS05060	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K05K4_RS05070	COG4591	ABC-type transport system involved in lipoprotein release permease component
K05K4_RS05075	COG1136	(ABC) transporter
K05K4_RS05080	COG4591	ABC-type transport system involved in lipoprotein release permease component
K05K4_RS05090	COG0658	competence protein
K05K4_RS05090	COG2333	competence protein COMEC
K05K4_RS05095	COG1132	(ABC) transporter
K05K4_RS05115	COG2719	SpoVR family
K05K4_RS05120	COG2718	Belongs to the UPF0229 family
K05K4_RS05125	COG2766	serine protein kinase
K05K4_RS05135	COG3013	Belongs to the UPF0304 family
K05K4_RS05145	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K05K4_RS05155	COG1882	Formate acetyltransferase
K05K4_RS05200	COG0708	Exodeoxyribonuclease III
K05K4_RS05210	COG3923	Primosomal replication protein n
K05K4_RS05215	COG0730	response to heat
K05K4_RS05220	COG1199	ATP-dependent helicase activity
K05K4_RS05230	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K05K4_RS05235	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
K05K4_RS05240	COG1187	pseudouridine synthase activity
K05K4_RS05250	COG1278	Cold shock
K05K4_RS05255	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
K05K4_RS05260	COG0542	response to heat
K05K4_RS05265	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K05K4_RS05270	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
K05K4_RS05275	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
K05K4_RS05295	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K05K4_RS05300	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K05K4_RS05305	COG0297	glycogen (starch) synthase activity
K05K4_RS05325	COG3070	regulator of competence-specific genes
K05K4_RS05330	COG1609	Transcriptional regulator
K05K4_RS05335	COG3381	protein complex oligomerization
K05K4_RS05340	COG0745	RESPONSE REGULATOR receiver
K05K4_RS05345	COG1434	Gram-negative-bacterium-type cell wall biogenesis
K05K4_RS05350	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K05K4_RS05355	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
K05K4_RS05360	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
K05K4_RS05365	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K05K4_RS05385	COG0189	ligase activity
K05K4_RS05385	COG4067	protein conserved in archaea
K05K4_RS05395	COG0500	methyltransferase
K05K4_RS05405	COG1801	Protein of unknown function DUF72
K05K4_RS05415	COG0217	transcriptional regulatory protein
K05K4_RS05420	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
K05K4_RS05425	COG0632	four-way junction helicase activity
K05K4_RS05430	COG2255	four-way junction helicase activity
K05K4_RS05435	COG1271	oxidase subunit
K05K4_RS05440	COG1294	oxidase, subunit
K05K4_RS05445	COG4890	Cyd operon protein YbgT
K05K4_RS05455	COG0824	Thioesterase
K05K4_RS05460	COG0811	peptide transport
K05K4_RS05475	COG0823	Involved in the tonB-independent uptake of proteins
K05K4_RS05480	COG2885	chlorophyll binding
K05K4_RS05485	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
K05K4_RS05490	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
K05K4_RS05500	COG3766	membrane
K05K4_RS05510	COG0754	glutathionylspermidine amidase activity
K05K4_RS05520	COG5002	protein histidine kinase activity
K05K4_RS05520	COG0784	Response regulator, receiver
K05K4_RS05535	COG1294	oxidase, subunit
K05K4_RS05540	COG1271	oxidase subunit
K05K4_RS05560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K05K4_RS05565	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K05K4_RS05590	COG3568	Endonuclease Exonuclease Phosphatase
K05K4_RS05615	COG0583	DNA-binding transcription factor activity
K05K4_RS05625	COG0686	Belongs to the AlaDH PNT family
K05K4_RS05635	COG1674	ftsk spoiiie
K05K4_RS05645	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K05K4_RS05665	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K05K4_RS05670	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K05K4_RS05690	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
K05K4_RS05710	COG0300	oxidoreductase activity
K05K4_RS05725	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K05K4_RS05735	COG2268	Band 7 protein
K05K4_RS05745	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K05K4_RS05750	COG2915	High frequency lysogenization protein hflD homolog
K05K4_RS05765	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K05K4_RS05775	COG1757	Na H antiporter
K05K4_RS05785	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K05K4_RS05795	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
K05K4_RS05795	COG0131	Imidazoleglycerol-phosphate dehydratase
K05K4_RS05800	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
K05K4_RS05805	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K05K4_RS05815	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K05K4_RS05815	COG0140	phosphoribosyl-ATP diphosphatase activity
K05K4_RS05820	COG3012	SEC-C Motif Domain Protein
K05K4_RS05825	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
K05K4_RS05830	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K05K4_RS05835	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K05K4_RS05840	COG0215	cysteine-tRNA ligase activity
K05K4_RS05845	COG1435	thymidine kinase activity
K05K4_RS05875	COG2116	formate transmembrane transporter activity
K05K4_RS05885	COG0390	transport system, permease component
K05K4_RS05890	COG4459	periplasmic nitrate reductase
K05K4_RS05895	COG3005	denitrification pathway
K05K4_RS05900	COG0243	molybdopterin cofactor binding
K05K4_RS05915	COG1227	inorganic diphosphatase activity
K05K4_RS05925	COG4172	Belongs to the ABC transporter superfamily
K05K4_RS05935	COG4171	peptide transport system, permease
K05K4_RS05950	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
K05K4_RS05955	COG1842	Phage shock protein A
K05K4_RS05965	COG1983	PspC domain protein
K05K4_RS05985	COG2818	Glycosylase
K05K4_RS05990	COG5380	lipid catabolic process
K05K4_RS05995	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
K05K4_RS06000	COG0626	cystathionine gamma-synthase activity
K05K4_RS06010	COG0733	neurotransmitter:sodium symporter activity
K05K4_RS06015	COG0564	pseudouridine synthase activity
K05K4_RS06025	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K05K4_RS06030	COG1151	hydroxylamine reductase activity
K05K4_RS06035	COG3604	Transcriptional regulator
K05K4_RS06050	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K05K4_RS06055	COG4136	ATPase activity
K05K4_RS06060	COG4135	transport system, permease component
K05K4_RS06065	COG4134	Bacterial extracellular solute-binding protein
K05K4_RS06075	COG3313	Fe-S protein
K05K4_RS06100	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
K05K4_RS06120	COG1061	Type III restriction enzyme res subunit
K05K4_RS06125	COG1187	pseudouridine synthase activity
K05K4_RS06135	COG2814	Major facilitator Superfamily
K05K4_RS06145	COG0702	epimerase
K05K4_RS06150	COG0534	Mate efflux family protein
K05K4_RS06170	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K05K4_RS06185	COG1960	acyl-CoA dehydrogenase activity
K05K4_RS06190	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K05K4_RS06195	COG2985	domain, Protein
K05K4_RS06195	COG3273	potassium ion transport
K05K4_RS06200	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K05K4_RS06210	COG1737	Transcriptional regulator
K05K4_RS06215	COG0076	glutamate decarboxylase activity
K05K4_RS06225	COG2431	L-lysine efflux transmembrane transporter activity
K05K4_RS06245	COG3070	regulator of competence-specific genes
K05K4_RS06260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K05K4_RS06260	COG4191	Histidine kinase
K05K4_RS06270	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
K05K4_RS06280	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
K05K4_RS06285	COG4988	ABC transporter
K05K4_RS06290	COG0492	ferredoxin-NADP+ reductase activity
K05K4_RS06315	COG0471	metal ion transport
K05K4_RS06320	COG2949	membrane
K05K4_RS06325	COG0281	malic enzyme
K05K4_RS06330	COG1643	Atp-dependent helicase
K05K4_RS06345	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K05K4_RS06380	COG0247	lactate metabolic process
K05K4_RS06380	COG0277	FAD linked oxidase domain protein
K05K4_RS06395	COG2986	histidine ammonia-lyase
K05K4_RS06400	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
K05K4_RS06405	COG0010	Belongs to the arginase family
K05K4_RS06410	COG1228	amidohydrolase
K05K4_RS06415	COG2188	Transcriptional regulator
K05K4_RS06430	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K05K4_RS06440	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K05K4_RS06450	COG0393	Putative heavy-metal-binding
K05K4_RS06485	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K05K4_RS06490	COG0072	phenylalanine-tRNA ligase activity
K05K4_RS06490	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K05K4_RS06500	COG0776	regulation of translation
K05K4_RS06510	COG0500	methyltransferase
K05K4_RS06515	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
K05K4_RS06520	COG0295	cytidine deaminase activity
K05K4_RS06525	COG1346	cytolysis
K05K4_RS06530	COG1380	Effector of murein hydrolase LrgA
K05K4_RS06535	COG2925	Exonuclease
K05K4_RS06590	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K05K4_RS06620	COG1484	DNA-dependent DNA replication
K05K4_RS06765	COG1823	symporter activity
K05K4_RS06770	COG0702	epimerase
K05K4_RS06775	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
K05K4_RS06780	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
K05K4_RS06800	COG2988	succinylglutamate desuccinylase activity
K05K4_RS06805	COG4139	cobalamin transport
K05K4_RS06810	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
K05K4_RS06830	COG0583	DNA-binding transcription factor activity
K05K4_RS06840	COG1451	nucleotide metabolic process
K05K4_RS06845	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
K05K4_RS06875	COG3938	Belongs to the proline racemase family
K05K4_RS06890	COG2423	ornithine cyclodeaminase activity
K05K4_RS06895	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K05K4_RS06900	COG3842	ATPase activity
K05K4_RS06905	COG1176	ABC-type spermidine putrescine transport system, permease component I
K05K4_RS06910	COG1177	transmembrane transport
K05K4_RS06920	COG3291	Pkd domain containing protein
K05K4_RS06940	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K05K4_RS06945	COG0601	transmembrane transport
K05K4_RS06955	COG2195	Cleaves the N-terminal amino acid of tripeptides
K05K4_RS06965	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
K05K4_RS06975	COG0625	glutathione transferase activity
K05K4_RS07025	COG3755	Protein conserved in bacteria
K05K4_RS07050	COG1742	UPF0060 membrane protein
K05K4_RS07065	COG1757	Na H antiporter
K05K4_RS07070	COG0174	glutamine synthetase
K05K4_RS07080	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
K05K4_RS07085	COG1396	sequence-specific DNA binding
K05K4_RS07085	COG1917	Cupin 2, conserved barrel domain protein
K05K4_RS07090	COG1012	belongs to the aldehyde dehydrogenase family
K05K4_RS07095	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K05K4_RS07105	COG2957	Belongs to the agmatine deiminase family
K05K4_RS07110	COG1012	belongs to the aldehyde dehydrogenase family
K05K4_RS07115	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K05K4_RS07120	COG2200	EAL domain
K05K4_RS07130	COG1846	Transcriptional regulator
K05K4_RS07135	COG2315	Protein conserved in bacteria
K05K4_RS07175	COG3063	Type IV pilus biogenesis stability protein PilW
K05K4_RS07180	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
K05K4_RS07195	COG1560	Kdo2-lipid A biosynthetic process
K05K4_RS07205	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K05K4_RS07330	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
K05K4_RS07335	COG1280	lysine exporter protein (LysE YggA)
K05K4_RS07370	COG1368	sulfuric ester hydrolase activity
K05K4_RS07375	COG2113	Glycine betaine
K05K4_RS07380	COG4176	ABC-type proline glycine betaine transport system permease component
K05K4_RS07385	COG4175	Glycine betaine
K05K4_RS07400	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K05K4_RS07405	COG0456	acetyltransferase
K05K4_RS07410	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K05K4_RS07415	COG0662	Cupin 2, conserved barrel domain protein
K05K4_RS07420	COG0527	aspartate kinase activity
K05K4_RS07425	COG3119	arylsulfatase activity
K05K4_RS07440	COG0641	radical SAM
K05K4_RS07455	COG3119	arylsulfatase activity
K05K4_RS07480	COG1538	Outer membrane efflux protein
K05K4_RS07495	COG1349	DNA-binding transcription factor activity
K05K4_RS07500	COG0673	inositol 2-dehydrogenase activity
K05K4_RS07505	COG4702	Belongs to the UPF0303 family
K05K4_RS07530	COG0471	metal ion transport
K05K4_RS07545	COG3300	MHYT domain
K05K4_RS07545	COG5001	Diguanylate cyclase
K05K4_RS07560	COG1328	CTP reductase activity
K05K4_RS07565	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K05K4_RS07575	COG0861	Integral membrane protein TerC family
K05K4_RS07585	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
K05K4_RS07595	COG0814	amino acid
K05K4_RS07610	COG1120	ATPase activity
K05K4_RS07615	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K05K4_RS07625	COG4774	siderophore transport
K05K4_RS07635	COG1132	(ABC) transporter
K05K4_RS07640	COG1132	(ABC) transporter
K05K4_RS07655	COG0583	DNA-binding transcription factor activity
K05K4_RS07680	COG0443	Heat shock 70 kDa protein
K05K4_RS07685	COG0443	Heat shock 70 kDa protein
K05K4_RS07730	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
K05K4_RS07735	COG1643	Atp-dependent helicase
K05K4_RS07750	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K05K4_RS07760	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K05K4_RS07765	COG1215	transferase activity, transferring glycosyl groups
K05K4_RS07770	COG0438	transferase activity, transferring glycosyl groups
K05K4_RS07800	COG0438	transferase activity, transferring glycosyl groups
K05K4_RS07805	COG0438	transferase activity, transferring glycosyl groups
K05K4_RS07810	COG2204	response regulator
K05K4_RS07845	COG1793	dna ligase
K05K4_RS07855	COG0534	Mate efflux family protein
K05K4_RS07860	COG0307	riboflavin synthase, alpha
K05K4_RS07870	COG3001	Fructosamine kinase
K05K4_RS07880	COG3706	GGDEF domain
K05K4_RS07890	COG0791	NLP P60 protein
K05K4_RS07925	COG3148	PFAM DTW domain containing protein
K05K4_RS07930	COG1940	carbohydrate kinase activity
K05K4_RS07945	COG0746	molybdenum cofactor guanylyltransferase activity
K05K4_RS07950	COG3842	ATPase activity
K05K4_RS07965	COG2204	response regulator
K05K4_RS07970	COG4191	Histidine kinase
K05K4_RS07980	COG0488	(ABC) transporter
K05K4_RS07985	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K05K4_RS08005	COG3381	protein complex oligomerization
K05K4_RS08015	COG3383	formate dehydrogenase (NAD+) activity
K05K4_RS08015	COG0243	molybdopterin cofactor binding
K05K4_RS08020	COG0437	4 iron, 4 sulfur cluster binding
K05K4_RS08050	COG0004	ammonium transporteR
K05K4_RS08055	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K05K4_RS08060	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K05K4_RS08070	COG1177	transmembrane transport
K05K4_RS08080	COG3842	ATPase activity
K05K4_RS08105	COG0589	response to stress
K05K4_RS08110	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K05K4_RS08125	COG2217	Heavy metal translocating P-type atpase
K05K4_RS08135	COG2010	Cytochrome c
K05K4_RS08150	COG3278	Belongs to the heme-copper respiratory oxidase family
K05K4_RS08165	COG2205	protein histidine kinase activity
K05K4_RS08165	COG0784	Response regulator, receiver
K05K4_RS08215	COG4128	Pfam Zonular occludens toxin
K05K4_RS08245	COG3120	sequence-specific DNA binding
K05K4_RS08250	COG1067	ATP-dependent peptidase activity
K05K4_RS08255	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K05K4_RS08270	COG0488	(ABC) transporter
K05K4_RS08280	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K05K4_RS08280	COG0116	Belongs to the methyltransferase superfamily
K05K4_RS08290	COG0167	dihydroorotate dehydrogenase activity
K05K4_RS08295	COG2902	Dehydrogenase
K05K4_RS08305	COG0308	aminopeptidase N
K05K4_RS08320	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
K05K4_RS08325	COG1956	GAF domain-containing protein
K05K4_RS08330	COG1132	(ABC) transporter
K05K4_RS08335	COG2995	paraquat-inducible protein a
K05K4_RS08340	COG3008	intermembrane lipid transfer
K05K4_RS08365	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K05K4_RS08370	COG1666	GTP binding
K05K4_RS08385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K05K4_RS08390	COG4597	amino acid ABC transporter
K05K4_RS08395	COG0765	amino acid transport
K05K4_RS08400	COG1126	abc transporter atp-binding protein
K05K4_RS08405	COG0670	Belongs to the BI1 family
K05K4_RS08420	COG2920	part of a sulfur-relay system
K05K4_RS08425	COG1254	Belongs to the acylphosphatase family
K05K4_RS08430	COG0840	transmembrane signaling receptor activity
K05K4_RS08450	COG2885	chlorophyll binding
K05K4_RS08475	COG2199	diguanylate cyclase activity
K05K4_RS08475	COG2203	Gaf domain
K05K4_RS08480	COG1414	Transcriptional regulator
K05K4_RS08490	COG0656	L-ascorbic acid biosynthetic process
K05K4_RS08495	COG0583	DNA-binding transcription factor activity
K05K4_RS08505	COG0583	DNA-binding transcription factor activity
K05K4_RS08510	COG2814	Major facilitator Superfamily
K05K4_RS08530	COG1335	isochorismatase
K05K4_RS08535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K05K4_RS08550	COG0646	methionine synthase
K05K4_RS08550	COG1410	methionine synthase
K05K4_RS08555	COG1126	abc transporter atp-binding protein
K05K4_RS08560	COG0765	amino acid transport
K05K4_RS08565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K05K4_RS08580	COG0583	DNA-binding transcription factor activity
K05K4_RS08595	COG0583	DNA-binding transcription factor activity
K05K4_RS08605	COG0583	DNA-binding transcription factor activity
K05K4_RS08620	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
K05K4_RS08625	COG0602	queuosine metabolic process
K05K4_RS08630	COG0561	phosphatase activity
K05K4_RS08655	COG2828	Protein conserved in bacteria
K05K4_RS08665	COG0372	Belongs to the citrate synthase family
K05K4_RS08670	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
K05K4_RS08705	COG0730	response to heat
K05K4_RS08710	COG2358	TRAP transporter, solute receptor (TAXI family
K05K4_RS08725	COG0457	Tetratricopeptide repeat
K05K4_RS08795	COG4790	Type iii secretion
K05K4_RS08800	COG4794	Type iii secretion
K05K4_RS08805	COG4791	protein targeting
K05K4_RS08810	COG4792	protein secretion
K05K4_RS08815	COG2207	Transcriptional regulator
K05K4_RS08845	COG3177	Filamentation induced by cAMP protein fic
K05K4_RS08865	COG4669	(LipO)protein
K05K4_RS08935	COG1012	belongs to the aldehyde dehydrogenase family
K05K4_RS08940	COG3284	Transcriptional regulator
K05K4_RS08955	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
K05K4_RS08960	COG0363	glucosamine-6-phosphate deaminase activity
K05K4_RS08965	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K05K4_RS08970	COG2207	Transcriptional regulator
K05K4_RS08980	COG4565	transcriptional regulatory protein
K05K4_RS08985	COG3290	protein histidine kinase activity
K05K4_RS09000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K05K4_RS09015	COG0583	DNA-binding transcription factor activity
K05K4_RS09030	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
K05K4_RS09040	COG2985	domain, Protein
K05K4_RS09065	COG2272	Belongs to the type-B carboxylesterase lipase family
K05K4_RS09075	COG0729	surface antigen
K05K4_RS09085	COG1280	lysine exporter protein (LysE YggA)
K05K4_RS09090	COG1280	lysine exporter protein (LysE YggA)
K05K4_RS09095	COG5507	3-demethylubiquinone-9 3-methyltransferase
K05K4_RS09115	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K05K4_RS09125	COG0110	maltose O-acetyltransferase activity
K05K4_RS09175	COG2801	Transposase and inactivated derivatives
K05K4_RS09215	COG1683	Conserved Protein
K05K4_RS09300	COG2801	Transposase and inactivated derivatives
K05K4_RS09335	COG1403	HNH endonuclease
K05K4_RS09435	COG4974	Belongs to the 'phage' integrase family
K05K4_RS09445	COG3706	GGDEF domain
K05K4_RS09460	COG2985	domain, Protein
K05K4_RS09465	COG0076	glutamate decarboxylase activity
K05K4_RS09470	COG2963	transposase activity
K05K4_RS09475	COG0598	Magnesium transport protein CorA
K05K4_RS09485	COG0387	Pfam Sodium calcium exchanger
K05K4_RS09490	COG0387	Pfam Sodium calcium exchanger
K05K4_RS09505	COG1289	transmembrane transporter activity
K05K4_RS09520	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
K05K4_RS09530	COG2985	domain, Protein
K05K4_RS09535	COG0025	NhaP-type Na H and K H
K05K4_RS09565	COG3302	dmso reductase anchor subunit
K05K4_RS09570	COG0437	4 iron, 4 sulfur cluster binding
K05K4_RS09575	COG0243	molybdopterin cofactor binding
K05K4_RS09585	COG2221	Nitrite and sulphite reductase 4Fe-4S
K05K4_RS09585	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K05K4_RS09590	COG2205	protein histidine kinase activity
K05K4_RS09590	COG0784	Response regulator, receiver
K05K4_RS09660	COG3477	response to acidic pH
K05K4_RS09665	COG3287	FIST C domain
K05K4_RS09665	COG2200	EAL domain
K05K4_RS09665	COG2199	diguanylate cyclase activity
K05K4_RS09670	COG2197	response regulator
K05K4_RS09745	COG1472	Belongs to the glycosyl hydrolase 3 family
K05K4_RS09755	COG2205	protein histidine kinase activity
K05K4_RS09755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K05K4_RS09760	COG2197	response regulator
K05K4_RS09830	COG1335	isochorismatase
K05K4_RS09945	COG4628	conserved protein (DUF2132)
K05K4_RS09995	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K05K4_RS10005	COG3768	UPF0283 membrane protein
K05K4_RS10010	COG3106	COG3106 Predicted ATPase
K05K4_RS10030	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K05K4_RS10035	COG0784	Response regulator, receiver
K05K4_RS10035	COG2205	protein histidine kinase activity
K05K4_RS10045	COG0494	nUDIX hydrolase
K05K4_RS10050	COG0814	amino acid
K05K4_RS10055	COG1760	l-serine dehydratase
K05K4_RS10060	COG2200	EAL domain
K05K4_RS10070	COG0720	synthase
K05K4_RS10075	COG0840	transmembrane signaling receptor activity
K05K4_RS10080	COG0017	Asparaginyl-tRNA synthetase
K05K4_RS10090	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K05K4_RS10105	COG1448	Aminotransferase
K05K4_RS10125	COG0840	transmembrane signaling receptor activity
K05K4_RS10130	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K05K4_RS10160	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
K05K4_RS10175	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K05K4_RS10180	COG3108	Peptidase M15
K05K4_RS10185	COG2989	Protein conserved in bacteria
K05K4_RS10210	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K05K4_RS10220	COG4235	cytochrome complex assembly
K05K4_RS10220	COG3088	subunit of a heme lyase
K05K4_RS10230	COG1138	Cytochrome C-type biogenesis protein
K05K4_RS10235	COG3301	Polysulphide reductase, NrfD
K05K4_RS10240	COG0437	4 iron, 4 sulfur cluster binding
K05K4_RS10250	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
K05K4_RS10270	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K05K4_RS10275	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K05K4_RS10305	COG0019	diaminopimelate decarboxylase activity
K05K4_RS10345	COG0322	excinuclease ABC activity
K05K4_RS10350	COG2197	response regulator
K05K4_RS10355	COG0417	DNA replication proofreading
K05K4_RS10375	COG1187	pseudouridine synthase activity
K05K4_RS10385	COG0009	L-threonylcarbamoyladenylate synthase
K05K4_RS10390	COG0613	PHP domain protein
K05K4_RS10400	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K05K4_RS10405	COG0512	Glutamine amidotransferase of anthranilate synthase
K05K4_RS10415	COG0134	indole-3-glycerol-phosphate synthase activity
K05K4_RS10415	COG0135	phosphoribosylanthranilate isomerase activity
K05K4_RS10425	COG0159	tryptophan synthase activity
K05K4_RS10430	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K05K4_RS10435	COG0318	PFAM AMP-dependent synthetase and ligase
K05K4_RS10445	COG1301	dicarboxylic acid transport
K05K4_RS10465	COG2917	probably involved in intracellular septation
K05K4_RS10475	COG2350	Protein conserved in bacteria
K05K4_RS10485	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
K05K4_RS10490	COG0583	DNA-binding transcription factor activity
K05K4_RS10505	COG5001	Diguanylate cyclase
K05K4_RS10510	COG1032	radical SAM domain protein
K05K4_RS10530	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
K05K4_RS10535	COG0463	Glycosyl transferase, family 2
K05K4_RS10540	COG0745	RESPONSE REGULATOR receiver
K05K4_RS10545	COG3850	Histidine kinase
K05K4_RS10545	COG5002	protein histidine kinase activity
K05K4_RS10595	COG0577	efflux transmembrane transporter activity
K05K4_RS10595	COG1136	(ABC) transporter
K05K4_RS10600	COG0577	efflux transmembrane transporter activity
K05K4_RS10600	COG1136	(ABC) transporter
K05K4_RS10605	COG0577	efflux transmembrane transporter activity
K05K4_RS10605	COG1136	(ABC) transporter
K05K4_RS10615	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K05K4_RS10640	COG3118	belongs to the thioredoxin family
K05K4_RS10645	COG4232	protein-disulfide reductase activity
K05K4_RS10680	COG2863	cytochrome
K05K4_RS10685	COG3258	Cytochrome c
K05K4_RS10690	COG2995	paraquat-inducible protein a
K05K4_RS10695	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K05K4_RS10695	COG3008	intermembrane lipid transfer
K05K4_RS10715	COG4166	transmembrane transport
K05K4_RS10725	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
K05K4_RS10730	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
K05K4_RS10740	COG0539	negative regulation of cytoplasmic translation
K05K4_RS10745	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K05K4_RS10750	COG0616	signal peptide processing
K05K4_RS10755	COG1028	Short-chain dehydrogenase reductase Sdr
K05K4_RS10770	COG0587	DNA-directed DNA polymerase activity
K05K4_RS10775	COG0784	Response regulator, receiver
K05K4_RS10775	COG0835	chemotaxis
K05K4_RS10780	COG1940	carbohydrate kinase activity
K05K4_RS10785	COG0469	pyruvate kinase activity
K05K4_RS10790	COG4667	esterase of the alpha-beta hydrolase superfamily
K05K4_RS10805	COG0733	neurotransmitter:sodium symporter activity
K05K4_RS10820	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K05K4_RS10820	COG1263	PTS System
K05K4_RS10825	COG0084	hydrolase, TatD family'
K05K4_RS10830	COG0470	DNA polymerase III
K05K4_RS10835	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K05K4_RS10840	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K05K4_RS10870	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K05K4_RS10875	COG0416	fatty acid biosynthetic process
K05K4_RS10885	COG1399	metal-binding, possibly nucleic acid-binding protein
K05K4_RS10890	COG0424	maF-like protein
K05K4_RS10895	COG0564	pseudouridine synthase activity
K05K4_RS10905	COG1530	ribonuclease E activity
K05K4_RS10915	COG0659	secondary active sulfate transmembrane transporter activity
K05K4_RS10920	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K05K4_RS10925	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
K05K4_RS10935	COG0572	uridine kinase
K05K4_RS10945	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K05K4_RS10945	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K05K4_RS10965	COG2186	Transcriptional regulator
K05K4_RS10970	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K05K4_RS10975	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
K05K4_RS10980	COG3012	SEC-C Motif Domain Protein
K05K4_RS10980	COG3318	Belongs to the UPF0149 family
K05K4_RS10985	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K05K4_RS10990	COG3706	GGDEF domain
K05K4_RS10995	COG0366	Alpha amylase catalytic
K05K4_RS11000	COG1122	ATPase activity
K05K4_RS11005	COG4120	Belongs to the binding-protein-dependent transport system permease family
K05K4_RS11015	COG3092	negative regulation of chromosome organization
K05K4_RS11020	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K05K4_RS11025	COG0857	belongs to the CobB CobQ family
K05K4_RS11025	COG0280	phosphate acetyltransferase
K05K4_RS11035	COG0435	Glutathione S-transferase
K05K4_RS11045	COG0444	Belongs to the ABC transporter superfamily
K05K4_RS11050	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K05K4_RS11055	COG0601	transmembrane transport
K05K4_RS11065	COG0314	molybdopterin synthase activity
K05K4_RS11070	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
K05K4_RS11075	COG0315	cyclic pyranopterin monophosphate synthase activity
K05K4_RS11080	COG0521	Mo-molybdopterin cofactor biosynthetic process
K05K4_RS11085	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K05K4_RS11090	COG0391	Required for morphogenesis under gluconeogenic growth conditions
K05K4_RS11095	COG2198	Histidine kinase
K05K4_RS11100	COG2204	response regulator
K05K4_RS11105	COG0556	nucleotide-excision repair
K05K4_RS11115	COG1882	Formate acetyltransferase
K05K4_RS11120	COG4657	Part of a membrane complex involved in electron transport
K05K4_RS11125	COG2878	Part of a membrane complex involved in electron transport
K05K4_RS11130	COG4656	Part of a membrane complex involved in electron transport
K05K4_RS11135	COG4658	electron transport chain
K05K4_RS11140	COG4659	FMN binding
K05K4_RS11145	COG4660	Part of a membrane complex involved in electron transport
K05K4_RS11150	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K05K4_RS11155	COG0346	lactoylglutathione lyase activity
K05K4_RS11165	COG2885	chlorophyll binding
K05K4_RS11175	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K05K4_RS11180	COG2056	Na+-H+ antiporter family
K05K4_RS11200	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
K05K4_RS11225	COG1012	belongs to the aldehyde dehydrogenase family
K05K4_RS11225	COG1454	alcohol dehydrogenase
K05K4_RS11230	COG2095	MarC family integral membrane protein
K05K4_RS11235	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K05K4_RS11240	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K05K4_RS11245	COG1757	Na H antiporter
K05K4_RS11260	COG3081	Nucleoid-associated protein
K05K4_RS11265	COG3082	Protein of unknown function (DUF1414)
K05K4_RS11280	COG0123	including yeast histone deacetylase and acetoin utilization protein
K05K4_RS11295	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K05K4_RS11300	COG0778	Nitroreductase
K05K4_RS11310	COG1902	pentaerythritol trinitrate reductase activity
K05K4_RS11310	COG0446	pyridine nucleotide-disulphide oxidoreductase
K05K4_RS11315	COG0616	signal peptide processing
K05K4_RS11320	COG0252	asparaginase activity
K05K4_RS11325	COG3139	Protein of unknown function (DUF1315)
K05K4_RS11335	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K05K4_RS11340	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K05K4_RS11355	COG2226	methyltransferase
K05K4_RS11375	COG1785	Belongs to the alkaline phosphatase family
K05K4_RS11385	COG0346	lactoylglutathione lyase activity
K05K4_RS11390	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
K05K4_RS11395	COG0668	transmembrane transport
K05K4_RS11400	COG2983	Belongs to the UPF0260 family
K05K4_RS11405	COG2261	transglycosylase associated protein
K05K4_RS11415	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K05K4_RS11420	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K05K4_RS11435	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K05K4_RS11440	COG2832	Protein of unknown function (DUF454)
K05K4_RS11450	COG0745	RESPONSE REGULATOR receiver
K05K4_RS11455	COG0583	DNA-binding transcription factor activity
K05K4_RS11460	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
K05K4_RS11465	COG1286	toxin biosynthetic process
K05K4_RS11470	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
K05K4_RS11475	COG0285	dihydrofolate synthase activity
K05K4_RS11480	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K05K4_RS11490	COG0101	tRNA pseudouridine synthase activity
K05K4_RS11500	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K05K4_RS11505	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K05K4_RS11515	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K05K4_RS11520	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K05K4_RS11520	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
K05K4_RS11525	COG0431	NADPH-dependent FMN reductase
K05K4_RS11540	COG3101	peptidyl-lysine hydroxylation
K05K4_RS11550	COG2860	membrane
K05K4_RS11555	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K05K4_RS11560	COG2890	protein-(glutamine-N5) methyltransferase activity
K05K4_RS11565	COG2840	Smr protein MutS2
K05K4_RS11570	COG2062	phosphohistidine phosphatase, SixA
K05K4_RS11585	COG1024	Enoyl-CoA hydratase
K05K4_RS11585	COG1250	3-hydroxyacyl-CoA dehydrogenase
K05K4_RS11590	COG0183	Belongs to the thiolase family
K05K4_RS11615	COG2067	long-chain fatty acid transport protein
K05K4_RS11625	COG4235	cytochrome complex assembly
K05K4_RS11625	COG3088	subunit of a heme lyase
K05K4_RS11635	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K05K4_RS11640	COG1138	Cytochrome C-type biogenesis protein
K05K4_RS11645	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
K05K4_RS11650	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K05K4_RS11655	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K05K4_RS11660	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K05K4_RS11665	COG4133	protoheme IX ABC transporter activity
K05K4_RS11675	COG0835	chemotaxis
K05K4_RS11685	COG1192	Involved in chromosome partitioning
K05K4_RS11690	COG2201	protein-glutamate methylesterase activity
K05K4_RS11695	COG2198	Histidine kinase
K05K4_RS11695	COG0643	Histidine kinase
K05K4_RS11695	COG0784	Response regulator, receiver
K05K4_RS11700	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
K05K4_RS11735	COG1684	flagellar biosynthetic protein fliR
K05K4_RS11740	COG1987	bacterial-type flagellum assembly
K05K4_RS11795	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K05K4_RS11805	COG1677	Flagellar hook-basal body complex protein FliE
K05K4_RS11825	COG1516	flagellar protein fliS
K05K4_RS11835	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
K05K4_RS11840	COG1334	flagellar protein FlaG
K05K4_RS11845	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K05K4_RS11850	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K05K4_RS11860	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K05K4_RS11865	COG2837	iron assimilation
K05K4_RS11890	COG1393	Belongs to the ArsC family
K05K4_RS11895	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K05K4_RS11910	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
K05K4_RS11915	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K05K4_RS11950	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K05K4_RS12030	COG0210	DNA helicase
K05K4_RS12045	COG2205	protein histidine kinase activity
K05K4_RS12045	COG0784	Response regulator, receiver
K05K4_RS12055	COG1278	Cold shock
K05K4_RS12075	COG1278	Cold shock
K05K4_RS12080	COG4974	Belongs to the 'phage' integrase family
K05K4_RS12085	COG0330	HflC and HflK could
K05K4_RS12105	COG1278	Cold shock
K05K4_RS12125	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K05K4_RS12140	COG4783	chaperone-mediated protein folding
K05K4_RS12145	COG1393	Belongs to the ArsC family
K05K4_RS12165	COG2233	PERMEase
K05K4_RS12170	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K05K4_RS12175	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K05K4_RS12180	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K05K4_RS12185	COG0121	glutamine amidotransferase
K05K4_RS12190	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
K05K4_RS12195	COG1960	acyl-CoA dehydrogenase activity
K05K4_RS12230	COG0328	RNA-DNA hybrid ribonuclease activity
K05K4_RS12235	COG2226	methyltransferase
K05K4_RS12240	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K05K4_RS12245	COG0741	lytic transglycosylase activity
K05K4_RS12245	COG1388	LysM domain
K05K4_RS12255	COG3021	interspecies interaction between organisms
K05K4_RS12260	COG0347	Belongs to the P(II) protein family
K05K4_RS12275	COG0825	malonyl-CoA metabolic process
K05K4_RS12280	COG0587	DNA-directed DNA polymerase activity
K05K4_RS12290	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K05K4_RS12295	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K05K4_RS12305	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K05K4_RS12310	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
K05K4_RS12320	COG0750	zinc metalloprotease
K05K4_RS12325	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
K05K4_RS12330	COG0575	Belongs to the CDS family
K05K4_RS12335	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K05K4_RS12340	COG0233	cytoplasmic translational termination
K05K4_RS12345	COG0528	UMP kinase activity
K05K4_RS12350	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K05K4_RS12355	COG0052	Belongs to the universal ribosomal protein uS2 family
K05K4_RS12360	COG0024	Methionine aminopeptidase
K05K4_RS12365	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
K05K4_RS12375	COG0564	pseudouridine synthase activity
K05K4_RS12380	COG3098	single-species biofilm formation
K05K4_RS12415	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K05K4_RS12420	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K05K4_RS12445	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
K05K4_RS12455	COG0254	rRNA binding
K05K4_RS12460	COG1720	tRNA m6t6A37 methyltransferase activity
K05K4_RS12465	COG0442	prolyl-tRNA aminoacylation
K05K4_RS12485	COG0733	neurotransmitter:sodium symporter activity
K05K4_RS12500	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K05K4_RS12505	COG0514	ATP-dependent DNA helicase (RecQ)
K05K4_RS12535	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K05K4_RS12590	COG3621	Patatin-like phospholipase
K05K4_RS12625	COG0659	secondary active sulfate transmembrane transporter activity
K05K4_RS12630	COG0589	response to stress
K05K4_RS12635	COG0519	Catalyzes the synthesis of GMP from XMP
K05K4_RS12715	COG1477	protein flavinylation
K05K4_RS12720	COG2871	sodium ion transport
K05K4_RS12725	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K05K4_RS12730	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K05K4_RS12735	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K05K4_RS12740	COG1805	sodium ion transport
K05K4_RS12745	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K05K4_RS12750	COG0271	Belongs to the BolA IbaG family
K05K4_RS12755	COG2813	Specifically methylates the guanine in position
K05K4_RS12760	COG3056	Lipoprotein
K05K4_RS12780	COG1595	DNA-templated transcription, initiation
K05K4_RS12805	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K05K4_RS12810	COG0693	protein deglycase activity
K05K4_RS12815	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K05K4_RS12820	COG3706	GGDEF domain
K05K4_RS12825	COG2166	iron-sulfur cluster assembly
K05K4_RS12830	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
K05K4_RS12835	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
K05K4_RS12850	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K05K4_RS12850	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
K05K4_RS12860	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K05K4_RS12865	COG1074	ATP-dependent DNA helicase activity
K05K4_RS12875	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
K05K4_RS12910	COG0270	DNA (cytosine-5-)-methyltransferase activity
K05K4_RS12935	COG3141	response to X-ray
K05K4_RS12950	COG2171	N-acyltransferase activity
K05K4_RS12955	COG0584	glycerophosphoryl diester phosphodiesterase
K05K4_RS12960	COG2271	Major facilitator Superfamily
K05K4_RS12970	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K05K4_RS12975	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
K05K4_RS12980	COG1349	DNA-binding transcription factor activity
K05K4_RS12985	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
K05K4_RS12990	COG0598	Magnesium transport protein CorA
K05K4_RS13010	COG1609	Transcriptional regulator
K05K4_RS13015	COG0583	DNA-binding transcription factor activity
K05K4_RS13055	COG1022	Amp-dependent synthetase and ligase
K05K4_RS13065	COG0583	DNA-binding transcription factor activity
K05K4_RS13070	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K05K4_RS13075	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
K05K4_RS13085	COG0560	Phosphoserine phosphatase
K05K4_RS13095	COG0813	purine-nucleoside phosphorylase activity
K05K4_RS13100	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
K05K4_RS13105	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
K05K4_RS13110	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
K05K4_RS13115	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K05K4_RS13120	COG0084	hydrolase, TatD family'
K05K4_RS13150	COG3153	acetyltransferase
K05K4_RS13155	COG3154	lipid carrier protein
K05K4_RS13170	COG0826	peptidase U32
K05K4_RS13175	COG0826	peptidase U32
K05K4_RS13180	COG0534	Mate efflux family protein
K05K4_RS13195	COG1185	polyribonucleotide nucleotidyltransferase activity
K05K4_RS13200	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K05K4_RS13205	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K05K4_RS13210	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K05K4_RS13215	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K05K4_RS13220	COG0195	Participates in both transcription termination and antitermination
K05K4_RS13225	COG0779	Required for maturation of 30S ribosomal subunits
K05K4_RS13240	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K05K4_RS13250	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K05K4_RS13255	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
K05K4_RS13260	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K05K4_RS13265	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
K05K4_RS13270	COG1534	Rna-binding protein
K05K4_RS13275	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K05K4_RS13280	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K05K4_RS13285	COG2027	D-alanyl-D-alanine carboxypeptidase
K05K4_RS13295	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K05K4_RS13300	COG0739	heme binding
K05K4_RS13325	COG0628	permease
K05K4_RS13335	COG2205	protein histidine kinase activity
K05K4_RS13335	COG0784	Response regulator, receiver
K05K4_RS13340	COG0747	negative chemotaxis
K05K4_RS13350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K05K4_RS13355	COG0444	Belongs to the ABC transporter superfamily
K05K4_RS13360	COG4608	Belongs to the ABC transporter superfamily
K05K4_RS13370	COG2971	BadF BadG BcrA BcrD
K05K4_RS13385	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K05K4_RS13390	COG3842	ATPase activity
K05K4_RS13400	COG1840	ABC-type Fe3 transport system, periplasmic component
K05K4_RS13405	COG0004	ammonium transporteR
K05K4_RS13415	COG3112	Uncharacterised protein family (UPF0231)
K05K4_RS13420	COG1049	propionate catabolic process, 2-methylcitrate cycle
K05K4_RS13425	COG1752	Esterase of the alpha-beta hydrolase superfamily
K05K4_RS13430	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K05K4_RS13435	COG1643	Atp-dependent helicase
K05K4_RS13440	COG1489	DNA binding
K05K4_RS13450	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K05K4_RS13460	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K05K4_RS13465	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
K05K4_RS13470	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
K05K4_RS13475	COG1560	Kdo2-lipid A biosynthetic process
K05K4_RS13485	COG0842	Transport permease protein
K05K4_RS13490	COG1131	(ABC) transporter
K05K4_RS13495	COG0659	secondary active sulfate transmembrane transporter activity
K05K4_RS13500	COG0288	reversible hydration of carbon dioxide
K05K4_RS13515	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K05K4_RS13520	COG0508	dehydrogenase complex catalyzes the overall conversion of
K05K4_RS13525	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
K05K4_RS13530	COG2186	Transcriptional regulator
K05K4_RS13540	COG0157	Belongs to the NadC ModD family
K05K4_RS13545	COG4969	Belongs to the N-Me-Phe pilin family
K05K4_RS13550	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K05K4_RS13555	COG1459	type II secretion system
K05K4_RS13565	COG0237	dephospho-CoA kinase activity
K05K4_RS13570	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
K05K4_RS13575	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
K05K4_RS13590	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K05K4_RS13595	COG0228	four-way junction DNA binding
K05K4_RS13600	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K05K4_RS13605	COG4137	Cytochrome C assembly protein
K05K4_RS13610	COG4536	flavin adenine dinucleotide binding
K05K4_RS13615	COG1854	S-ribosylhomocysteine lyase activity
K05K4_RS13630	COG0612	Peptidase, M16
K05K4_RS13635	COG1238	metal cluster binding
K05K4_RS13645	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
K05K4_RS13650	COG0511	ligase activity, forming carbon-carbon bonds
K05K4_RS13650	COG5016	pyruvate
K05K4_RS13655	COG3630	sodium ion export across plasma membrane
K05K4_RS13715	COG0527	aspartate kinase activity
K05K4_RS13720	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K05K4_RS13725	COG2137	regulation of response to DNA damage stimulus
K05K4_RS13735	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K05K4_RS13740	COG1546	Belongs to the CinA family
K05K4_RS13745	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K05K4_RS13750	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K05K4_RS13760	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K05K4_RS13765	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
K05K4_RS13775	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
K05K4_RS13780	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
K05K4_RS13785	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
K05K4_RS13790	COG0148	phosphopyruvate hydratase activity
K05K4_RS13795	COG0504	CTP synthase activity
K05K4_RS13800	COG3956	TIGRFAM MazG family protein
K05K4_RS13805	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K05K4_RS13815	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K05K4_RS13830	COG0736	holo-[acyl-carrier-protein] synthase activity
K05K4_RS13835	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
K05K4_RS13840	COG1381	Involved in DNA repair and RecF pathway recombination
K05K4_RS13845	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K05K4_RS13855	COG0681	Belongs to the peptidase S26 family
K05K4_RS13860	COG0481	GTPase activity
K05K4_RS13865	COG3086	response to oxidative stress
K05K4_RS13880	COG1595	DNA-templated transcription, initiation
K05K4_RS13890	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
K05K4_RS13900	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
K05K4_RS13920	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K05K4_RS13925	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K05K4_RS13930	COG3079	Belongs to the UPF0149 family
K05K4_RS13940	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
K05K4_RS13950	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K05K4_RS13955	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
K05K4_RS13960	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K05K4_RS13970	COG0583	DNA-binding transcription factor activity
K05K4_RS13985	COG0668	transmembrane transport
K05K4_RS13990	COG0191	fructose-bisphosphate aldolase activity
K05K4_RS14005	COG4771	TonB-dependent receptor
K05K4_RS14010	COG0583	DNA-binding transcription factor activity
K05K4_RS14015	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K05K4_RS14025	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K05K4_RS14035	COG3091	SprT-like family
K05K4_RS14040	COG2356	endonuclease I
K05K4_RS14045	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K05K4_RS14050	COG0189	ligase activity
K05K4_RS14055	COG1678	Uncharacterized ACR, COG1678
K05K4_RS14060	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K05K4_RS14075	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K05K4_RS14080	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K05K4_RS14085	COG0762	integral membrane protein
K05K4_RS14090	COG1872	DUF167
K05K4_RS14100	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
K05K4_RS14105	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K05K4_RS14110	COG2066	Belongs to the glutaminase family
K05K4_RS14120	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K05K4_RS14130	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
K05K4_RS14175	COG0840	transmembrane signaling receptor activity
K05K4_RS14255	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
K05K4_RS14260	COG1609	Transcriptional regulator
K05K4_RS14265	COG3394	polysaccharide catabolic process
K05K4_RS14270	COG1486	melibiose metabolic process
K05K4_RS14275	COG1447	Phosphotransferase system cellobiose-specific component IIA
K05K4_RS14280	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K05K4_RS14285	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K05K4_RS14290	COG0726	polysaccharide deacetylase
K05K4_RS14300	COG1028	Short-chain dehydrogenase reductase Sdr
K05K4_RS14315	COG0795	lipopolysaccharide-transporting ATPase activity
K05K4_RS14320	COG0795	lipopolysaccharide-transporting ATPase activity
K05K4_RS14325	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K05K4_RS14330	COG2927	DNA polymerase III (CHI subunit)
K05K4_RS14335	COG0525	valine-tRNA ligase activity
K05K4_RS14345	COG0456	acetyltransferase
K05K4_RS14375	COG0540	Belongs to the ATCase OTCase family
K05K4_RS14380	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
K05K4_RS14385	COG0251	oxidation-reduction process
K05K4_RS14390	COG0204	Acyl-transferase
K05K4_RS14395	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K05K4_RS14400	COG5007	Belongs to the BolA IbaG family
K05K4_RS14410	COG2854	intermembrane phospholipid transfer
K05K4_RS14415	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K05K4_RS14420	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K05K4_RS14425	COG1127	ABC transporter
K05K4_RS14435	COG0517	IMP dehydrogenase activity
K05K4_RS14435	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
K05K4_RS14445	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
K05K4_RS14450	COG1137	ATPase activity
K05K4_RS14460	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K05K4_RS14465	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K05K4_RS14470	COG1660	Displays ATPase and GTPase activities
K05K4_RS14475	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K05K4_RS14480	COG2239	Acts as a magnesium transporter
K05K4_RS14485	COG0312	modulator of DNA gyrase
K05K4_RS14490	COG3028	Belongs to the UPF0307 family
K05K4_RS14495	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K05K4_RS14500	COG0564	pseudouridine synthase activity
K05K4_RS14510	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K05K4_RS14515	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
K05K4_RS14520	COG0312	modulator of DNA gyrase
K05K4_RS14525	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K05K4_RS14530	COG3164	Protein of unknown function
K05K4_RS14540	COG0424	maF-like protein
K05K4_RS14545	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
K05K4_RS14550	COG1792	Involved in formation and maintenance of cell shape
K05K4_RS14555	COG1077	Cell shape determining protein MreB Mrl
K05K4_RS14590	COG2165	general secretion pathway protein
K05K4_RS14600	COG1459	type II secretion system
K05K4_RS14605	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K05K4_RS14615	COG3409	Peptidoglycan-binding domain 1 protein
K05K4_RS14615	COG3267	Type II secretory pathway component ExeA
K05K4_RS14620	COG1450	Type ii and iii secretion system protein
K05K4_RS14640	COG2200	EAL domain
K05K4_RS14640	COG2199	diguanylate cyclase activity
K05K4_RS14645	COG0629	single-stranded DNA binding
K05K4_RS14660	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K05K4_RS14675	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
K05K4_RS14685	COG0527	aspartate kinase activity
K05K4_RS14690	COG0646	methionine synthase
K05K4_RS14690	COG1410	methionine synthase
K05K4_RS14755	COG0175	sulfate reduction
K05K4_RS14760	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K05K4_RS14765	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K05K4_RS14785	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K05K4_RS14790	COG0735	belongs to the Fur family
K05K4_RS14800	COG0166	Belongs to the GPI family
K05K4_RS14805	COG0432	Pfam Uncharacterised protein family UPF0047
K05K4_RS14810	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K05K4_RS14835	COG2965	DNA replication, synthesis of RNA primer
K05K4_RS14840	COG0360	Binds together with S18 to 16S ribosomal RNA
K05K4_RS14845	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K05K4_RS14850	COG0338	D12 class N6 adenine-specific DNA methyltransferase
K05K4_RS14860	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K05K4_RS14865	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K05K4_RS14895	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
K05K4_RS14905	COG0678	peroxiredoxin activity
K05K4_RS14905	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K05K4_RS14910	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K05K4_RS14920	COG0165	Argininosuccinate lyase
K05K4_RS14920	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
K05K4_RS14925	COG0137	argininosuccinate synthase activity
K05K4_RS14935	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
K05K4_RS14945	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
K05K4_RS14955	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K05K4_RS14960	COG0527	aspartate kinase activity
K05K4_RS14960	COG0460	homoserine dehydrogenase
K05K4_RS14965	COG0626	cystathionine gamma-synthase activity
K05K4_RS14970	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
K05K4_RS14975	COG0281	malic enzyme
K05K4_RS14990	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K05K4_RS14995	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K05K4_RS15015	COG2923	Belongs to the DsrF TusC family
K05K4_RS15020	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
K05K4_RS15025	COG2964	Protein conserved in bacteria
K05K4_RS15030	COG0545	Peptidyl-prolyl cis-trans isomerase
K05K4_RS15045	COG1446	asparaginase
K05K4_RS15055	COG1047	Peptidyl-prolyl cis-trans
K05K4_RS15070	COG2249	NAD(P)H dehydrogenase (quinone) activity
K05K4_RS15075	COG0488	(ABC) transporter
K05K4_RS15085	COG0429	hydrolase of the alpha beta-hydrolase fold
K05K4_RS15095	COG3954	Phosphoribulokinase
K05K4_RS15100	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K05K4_RS15120	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K05K4_RS15125	COG0512	Glutamine amidotransferase of anthranilate synthase
K05K4_RS15140	COG0180	Tryptophanyl-tRNA synthetase
K05K4_RS15145	COG0546	phosphoglycolate phosphatase activity
K05K4_RS15150	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K05K4_RS15155	COG0557	exoribonuclease II activity
K05K4_RS15160	COG1959	2 iron, 2 sulfur cluster binding
K05K4_RS15165	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K05K4_RS15165	COG1017	nitric oxide dioxygenase activity
K05K4_RS15170	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
K05K4_RS15180	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K05K4_RS15185	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
K05K4_RS15190	COG0330	HflC and HflK could
K05K4_RS15195	COG0330	HflC and HflK could
K05K4_RS15200	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K05K4_RS15210	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K05K4_RS15215	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K05K4_RS15225	COG0802	atpase or kinase
K05K4_RS15235	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K05K4_RS15300	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
K05K4_RS15305	COG1162	GTPase activity
K05K4_RS15310	COG0688	phosphatidylethanolamine metabolic process
K05K4_RS15315	COG0471	metal ion transport
K05K4_RS15325	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
K05K4_RS15330	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K05K4_RS15335	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
K05K4_RS15340	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K05K4_RS15345	COG1045	serine acetyltransferase
K05K4_RS15350	COG4942	peptidase
K05K4_RS15370	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
K05K4_RS15375	COG1053	succinate dehydrogenase
K05K4_RS15380	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K05K4_RS15385	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
K05K4_RS15390	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
K05K4_RS15405	COG1509	lysine 2,3-aminomutase activity
K05K4_RS15410	COG1285	pathogenesis
K05K4_RS15420	COG0459	protein refolding
K05K4_RS15430	COG0534	Mate efflux family protein
K05K4_RS15435	COG0205	6-phosphofructokinase activity
K05K4_RS15445	COG3678	ATP-independent chaperone mediated protein folding
K05K4_RS15450	COG0745	RESPONSE REGULATOR receiver
K05K4_RS15455	COG2205	protein histidine kinase activity
K05K4_RS15465	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
K05K4_RS15470	COG3030	protein affecting phage T7 exclusion by the F plasmid
K05K4_RS15475	COG1027	Aspartate ammonia-lyase
K05K4_RS15480	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
K05K4_RS15485	COG4232	protein-disulfide reductase activity
K05K4_RS15495	COG3263	regulation of cellular component size
K05K4_RS15505	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K05K4_RS15530	COG2814	Major facilitator Superfamily
K05K4_RS15545	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K05K4_RS15550	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K05K4_RS15555	COG0511	ligase activity, forming carbon-carbon bonds
K05K4_RS15560	COG0439	Biotin carboxylase
K05K4_RS15565	COG2264	protein methyltransferase activity
K05K4_RS15570	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K05K4_RS15575	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
K05K4_RS15585	COG0488	(ABC) transporter
K05K4_RS15640	COG1982	Orn Lys Arg decarboxylase major
K05K4_RS15645	COG0531	amino acid
K05K4_RS15655	COG3710	Transcriptional regulator
K05K4_RS15660	COG0789	Transcriptional regulator
K05K4_RS15675	COG0151	Belongs to the GarS family
K05K4_RS15690	COG1253	flavin adenine dinucleotide binding
K05K4_RS15695	COG3068	Protein conserved in bacteria
K05K4_RS15705	COG1573	uracil-dna glycosylase
K05K4_RS15710	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K05K4_RS15715	COG2816	NAD+ diphosphatase activity
K05K4_RS15720	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
K05K4_RS15725	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K05K4_RS15730	COG0085	RNA polymerase activity
K05K4_RS15735	COG0222	ribosome binding
K05K4_RS15740	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K05K4_RS15755	COG0250	Participates in transcription elongation, termination and antitermination
K05K4_RS15760	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K05K4_RS15770	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K05K4_RS15805	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
K05K4_RS15805	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
K05K4_RS15810	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K05K4_RS15820	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K05K4_RS15895	COG4206	TonB-dependent receptor
K05K4_RS15915	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K05K4_RS15920	COG0534	Mate efflux family protein
K05K4_RS15925	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
K05K4_RS15935	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K05K4_RS15945	COG2937	Belongs to the GPAT DAPAT family
K05K4_RS15950	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
K05K4_RS15955	COG3161	chorismate lyase activity
K05K4_RS15960	COG1580	Controls the rotational direction of flagella during chemotaxis
K05K4_RS15965	COG0705	Rhomboid family
K05K4_RS15970	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K05K4_RS15985	COG2177	Part of the ABC transporter FtsEX involved in
K05K4_RS15990	COG2884	Cell division ATP-binding protein ftsE
K05K4_RS15995	COG0552	protein localization to endoplasmic reticulum
K05K4_RS16000	COG0742	ribosomal rna small subunit methyltransferase
K05K4_RS16010	COG2095	MarC family integral membrane protein
K05K4_RS16055	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K05K4_RS16060	COG0640	Transcriptional regulator
K05K4_RS16065	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
K05K4_RS16070	COG1280	lysine exporter protein (LysE YggA)
K05K4_RS16075	COG2267	carboxylic ester hydrolase activity
K05K4_RS16080	COG0561	phosphatase activity
K05K4_RS16095	COG3148	PFAM DTW domain containing protein
K05K4_RS16100	COG2199	diguanylate cyclase activity
K05K4_RS16100	COG2200	EAL domain
K05K4_RS16100	COG3287	FIST C domain
K05K4_RS16105	COG1011	Hydrolase
K05K4_RS16110	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
K05K4_RS16125	COG0019	diaminopimelate decarboxylase activity
K05K4_RS16135	COG1965	Belongs to the frataxin family
K05K4_RS16140	COG3072	Adenylate cyclase
K05K4_RS16145	COG0181	hydroxymethylbilane synthase activity
K05K4_RS16150	COG1587	Uroporphyrinogen-III synthase
K05K4_RS16155	COG2959	enzyme of heme biosynthesis
K05K4_RS16160	COG3071	HemY protein
K05K4_RS16205	COG0633	Ferredoxin
K05K4_RS16210	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
K05K4_RS16225	COG3118	belongs to the thioredoxin family
K05K4_RS16230	COG0513	Belongs to the DEAD box helicase family
K05K4_RS16235	COG0248	Ppx GppA phosphatase
K05K4_RS16245	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
K05K4_RS16255	COG0514	ATP-dependent DNA helicase (RecQ)
K05K4_RS16260	COG2962	Rard protein
K05K4_RS16270	COG1280	lysine exporter protein (LysE YggA)
K05K4_RS16275	COG0405	Gamma-glutamyltransferase
K05K4_RS16285	COG0210	DNA helicase
K05K4_RS16295	COG3220	belongs to the UPF0276 family
K05K4_RS16325	COG0006	proline dipeptidase activity
K05K4_RS16325	COG0006	proline dipeptidase activity
K05K4_RS16340	COG2104	thiamine diphosphate biosynthetic process
K05K4_RS16345	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K05K4_RS16365	COG2132	Multicopper oxidase
K05K4_RS16415	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
K05K4_RS16435	COG0009	L-threonylcarbamoyladenylate synthase
K05K4_RS16440	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
K05K4_RS16445	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K05K4_RS16450	COG0551	DNA topoisomerase type I activity
K05K4_RS16455	COG2922	Belongs to the Smg family
K05K4_RS16460	COG0758	DNA mediated transformation
K05K4_RS16470	COG0242	peptide deformylase activity
K05K4_RS16475	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K05K4_RS16480	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K05K4_RS16480	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K05K4_RS16485	COG0569	domain protein
K05K4_RS16490	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K05K4_RS16500	COG1272	protein, Hemolysin III
K05K4_RS16505	COG4326	sporulation control protein
K05K4_RS16515	COG3084	Protein conserved in bacteria
K05K4_RS16525	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
K05K4_RS16530	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K05K4_RS16535	COG0204	Acyl-transferase
K05K4_RS16545	COG0606	chelatase, subunit chli
K05K4_RS16555	COG3978	acetolactate synthase activity
K05K4_RS16560	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K05K4_RS16565	COG0129	dihydroxy-acid dehydratase activity
K05K4_RS16575	COG0583	DNA-binding transcription factor activity
K05K4_RS16580	COG2814	Major facilitator Superfamily
K05K4_RS16590	COG0765	amino acid transport
K05K4_RS16600	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K05K4_RS16605	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K05K4_RS16610	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K05K4_RS16615	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K05K4_RS16620	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K05K4_RS16625	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K05K4_RS16635	COG0356	it plays a direct role in the translocation of protons across the membrane
K05K4_RS16640	COG3312	ion transport
K05K4_RS16645	COG1475	DNA binding
K05K4_RS16650	COG1192	Involved in chromosome partitioning
K05K4_RS16655	COG0357	Ribosomal RNA small subunit methyltransferase G
K05K4_RS16660	COG0445	tRNA wobble uridine modification
K05K4_RS16665	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K05K4_RS16675	COG0706	membrane insertase activity
K05K4_RS16685	COG0594	ribonuclease P activity
K05K4_RS16695	COG1126	abc transporter atp-binding protein
K05K4_RS16720	COG1444	tRNA N-acetyltransferase activity
K05K4_RS16740	COG3340	Belongs to the peptidase S51 family
K05K4_RS16745	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K05K4_RS16750	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K05K4_RS16750	COG1263	PTS System
K05K4_RS16755	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
K05K4_RS16775	COG4166	transmembrane transport
K05K4_RS16820	COG0259	pyridoxamine-phosphate oxidase activity
K05K4_RS16845	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K05K4_RS16885	COG1132	(ABC) transporter
K05K4_RS16895	COG0513	Belongs to the DEAD box helicase family
K05K4_RS16900	COG2258	MOSC domain
K05K4_RS16965	COG3634	alkyl hydroperoxide reductase activity
K05K4_RS17010	COG1846	Transcriptional regulator
K05K4_RS17015	COG1764	response to oxidative stress
K05K4_RS17050	COG0577	efflux transmembrane transporter activity
K05K4_RS17055	COG1136	(ABC) transporter
K05K4_RS17070	COG0826	peptidase U32
K05K4_RS17100	COG1653	transport
K05K4_RS17105	COG0019	diaminopimelate decarboxylase activity
K05K4_RS17110	COG4264	IucA IucC family
K05K4_RS17135	COG4772	TonB-dependent receptor
K05K4_RS17140	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
K05K4_RS17145	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K05K4_RS17150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K05K4_RS17155	COG1120	ATPase activity
K05K4_RS17160	COG0840	transmembrane signaling receptor activity
K05K4_RS17165	COG0612	Peptidase, M16
K05K4_RS17175	COG0739	heme binding
K05K4_RS17190	COG2814	Major facilitator Superfamily
K05K4_RS17200	COG1609	Transcriptional regulator
K05K4_RS17205	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K05K4_RS17225	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K05K4_RS17225	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K05K4_RS17235	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K05K4_RS17240	COG1609	Transcriptional regulator
K05K4_RS17250	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K05K4_RS17265	COG0596	Alpha beta hydrolase
K05K4_RS17290	COG1760	l-serine dehydratase
K05K4_RS17300	COG4580	involved in the transport of maltose and maltodextrins
K05K4_RS17320	COG2356	endonuclease I
K05K4_RS17340	COG1982	Orn Lys Arg decarboxylase major
K05K4_RS17345	COG0531	amino acid
K05K4_RS17355	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
K05K4_RS17360	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
K05K4_RS17365	COG1162	GTPase activity
K05K4_RS17370	COG1263	PTS System
K05K4_RS17370	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K05K4_RS17375	COG1999	signal sequence binding
K05K4_RS17390	COG2909	trisaccharide binding
K05K4_RS17395	COG0058	SHG alpha-glucan phosphorylase activity
K05K4_RS17400	COG1640	4-alpha-glucanotransferase
K05K4_RS17405	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
K05K4_RS17410	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K05K4_RS17415	COG0366	Alpha amylase catalytic
K05K4_RS17430	COG3366	ferrous iron transmembrane transporter activity
K05K4_RS17435	COG0700	Nucleoside recognition
K05K4_RS17440	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K05K4_RS17445	COG3339	Conserved Protein
K05K4_RS17450	COG1301	dicarboxylic acid transport
K05K4_RS17460	COG0583	DNA-binding transcription factor activity
K05K4_RS17480	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K05K4_RS17485	COG1596	polysaccharide export
K05K4_RS17500	COG2095	MarC family integral membrane protein
K05K4_RS17505	COG4667	esterase of the alpha-beta hydrolase superfamily
K05K4_RS17510	COG3397	chitin binding
K05K4_RS17515	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
K05K4_RS17520	COG0415	Belongs to the DNA photolyase family
K05K4_RS17530	COG1054	Belongs to the UPF0176 family
K05K4_RS17540	COG1686	Belongs to the peptidase S11 family
K05K4_RS17565	COG0583	DNA-binding transcription factor activity
K05K4_RS17570	COG4628	conserved protein (DUF2132)
K05K4_RS17590	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
K05K4_RS17595	COG0628	permease
K05K4_RS17620	COG1289	transmembrane transporter activity
K05K4_RS17640	COG2814	Major facilitator Superfamily
K05K4_RS17650	COG0454	-acetyltransferase
K05K4_RS17660	COG0745	RESPONSE REGULATOR receiver
K05K4_RS17665	COG2205	protein histidine kinase activity
K05K4_RS17680	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K05K4_RS17685	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K05K4_RS17690	COG1882	Formate acetyltransferase
K05K4_RS17725	COG1360	Flagellar Motor Protein
K05K4_RS17730	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K05K4_RS17735	COG1191	sigma factor activity
K05K4_RS17740	COG1580	Controls the rotational direction of flagella during chemotaxis
K05K4_RS17755	COG1516	flagellar protein fliS
K05K4_RS17760	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
K05K4_RS17770	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K05K4_RS17785	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K05K4_RS17795	COG1987	bacterial-type flagellum assembly
K05K4_RS17835	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K05K4_RS17900	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K05K4_RS17960	COG0346	lactoylglutathione lyase activity
K05K4_RS17985	COG0745	RESPONSE REGULATOR receiver
K05K4_RS18010	COG3300	MHYT domain
K05K4_RS18010	COG5001	Diguanylate cyclase
K05K4_RS18015	COG0156	8-amino-7-oxononanoate synthase activity
K05K4_RS18020	COG1063	alcohol dehydrogenase
K05K4_RS18055	COG0668	transmembrane transport
K05K4_RS18065	COG1304	FMN binding
K05K4_RS18070	COG1620	l-lactate permease
K05K4_RS18075	COG0583	DNA-binding transcription factor activity
K05K4_RS18080	COG1505	serine-type exopeptidase activity
K05K4_RS18085	COG4172	Belongs to the ABC transporter superfamily
K05K4_RS18095	COG1067	ATP-dependent peptidase activity
K05K4_RS18105	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K05K4_RS18125	COG1247	-acetyltransferase
K05K4_RS18130	COG0437	4 iron, 4 sulfur cluster binding
K05K4_RS18135	COG0348	domain, Protein
K05K4_RS18155	COG1122	ATPase activity
K05K4_RS18160	COG4720	Psort location CytoplasmicMembrane, score
K05K4_RS18165	COG1566	PFAM secretion protein HlyD family protein
K05K4_RS18190	COG0813	purine-nucleoside phosphorylase activity
K05K4_RS18195	COG3272	Protein of unknown function (DUF1722)
K05K4_RS18200	COG0789	Transcriptional regulator
K05K4_RS18205	COG0415	Belongs to the DNA photolyase family
K05K4_RS18210	COG1376	ErfK ybiS ycfS ynhG family protein
K05K4_RS18210	COG1388	LysM domain
K05K4_RS18220	COG0513	Belongs to the DEAD box helicase family
K05K4_RS18225	COG1770	oligopeptidase
K05K4_RS18230	COG4771	TonB-dependent receptor
K05K4_RS18260	COG0573	inorganic phosphate transmembrane transporter activity
K05K4_RS18265	COG0581	inorganic phosphate transmembrane transporter activity
K05K4_RS18270	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K05K4_RS18285	COG2304	oxidoreductase activity
K05K4_RS18305	COG0714	Associated with various cellular activities
K05K4_RS18320	COG2197	response regulator
K05K4_RS18355	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
K05K4_RS18360	COG1120	ATPase activity
K05K4_RS18365	COG4774	siderophore transport
K05K4_RS18370	COG1132	(ABC) transporter
K05K4_RS18375	COG2205	protein histidine kinase activity
K05K4_RS18385	COG0569	domain protein
K05K4_RS18390	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K05K4_RS18395	COG0583	DNA-binding transcription factor activity
K05K4_RS18410	COG1012	belongs to the aldehyde dehydrogenase family
K05K4_RS18415	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K05K4_RS18420	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K05K4_RS18430	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
K05K4_RS18435	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K05K4_RS18465	COG2084	Dehydrogenase
K05K4_RS18470	COG0753	catalase activity
K05K4_RS18480	COG2130	NADP-dependent
K05K4_RS18485	COG1309	transcriptional regulator
K05K4_RS18490	COG3097	Belongs to the UPF0267 family
K05K4_RS18530	COG3206	protein involved in exopolysaccharide biosynthesis
K05K4_RS18530	COG0489	protein tyrosine kinase activity
K05K4_RS18545	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K05K4_RS18550	COG3842	ATPase activity
K05K4_RS18560	COG1175	transmembrane transport
K05K4_RS18565	COG3833	ABC-type maltose transport systems, permease component
K05K4_RS18595	COG2354	Protein conserved in bacteria
K05K4_RS18600	COG0418	dihydroorotase activity
K05K4_RS18610	COG0401	homolog of Blt101
K05K4_RS18615	COG0633	Ferredoxin
K05K4_RS18615	COG3217	Mosc domain protein beta barrel domain protein
K05K4_RS18615	COG0633	Ferredoxin
K05K4_RS18615	COG3217	Mosc domain protein beta barrel domain protein
K05K4_RS18625	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K05K4_RS18665	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
K05K4_RS18670	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K05K4_RS18680	COG0848	biopolymer transport protein
K05K4_RS18685	COG0811	peptide transport
K05K4_RS18690	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
K05K4_RS18700	COG3721	Heme iron utilization protein
K05K4_RS18705	COG0748	coenzyme F420 binding
K05K4_RS18715	COG0784	Response regulator, receiver
K05K4_RS18715	COG0835	chemotaxis
K05K4_RS18720	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K05K4_RS18725	COG0534	Mate efflux family protein
K05K4_RS18730	COG0444	Belongs to the ABC transporter superfamily
K05K4_RS18735	COG4608	Belongs to the ABC transporter superfamily
K05K4_RS18740	COG0747	negative chemotaxis
K05K4_RS18750	COG1349	DNA-binding transcription factor activity
K05K4_RS18755	COG2084	Dehydrogenase
K05K4_RS18760	COG3395	kinase activity
K05K4_RS18765	COG0235	Class ii aldolase
K05K4_RS18770	COG3622	Belongs to the hyi family
K05K4_RS18775	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K05K4_RS18780	COG2610	gluconate transmembrane transporter activity
K05K4_RS18800	COG0583	DNA-binding transcription factor activity
K05K4_RS18805	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K05K4_RS18815	COG4934	collagen metabolic process
K05K4_RS18825	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K05K4_RS18830	COG0789	Transcriptional regulator
K05K4_RS18835	COG0366	Alpha amylase catalytic
K05K4_RS18855	COG2249	NAD(P)H dehydrogenase (quinone) activity
K05K4_RS18860	COG0589	response to stress
K05K4_RS18865	COG0488	(ABC) transporter
K05K4_RS18870	COG1505	serine-type exopeptidase activity
K05K4_RS18880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K05K4_RS18890	COG2067	long-chain fatty acid transport protein
K05K4_RS18900	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K05K4_RS18925	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K05K4_RS18945	COG3383	formate dehydrogenase (NAD+) activity
K05K4_RS18955	COG0842	Transport permease protein
K05K4_RS18960	COG1131	(ABC) transporter
K05K4_RS18980	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
K05K4_RS18990	COG4145	pantothenate transmembrane transporter activity
K05K4_RS18995	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K05K4_RS19000	COG0800	Aldolase
K05K4_RS19010	COG2706	6-phosphogluconolactonase activity
K05K4_RS19015	COG0251	oxidation-reduction process
K05K4_RS19025	COG1881	PFAM PEBP family protein
K05K4_RS19035	COG0798	PFAM Bile acid sodium symporter
K05K4_RS19050	COG1733	regulation of RNA biosynthetic process
K05K4_RS19075	COG4989	oxidoreductase activity
K05K4_RS19100	COG0814	amino acid
K05K4_RS19115	COG3314	Sporulation integral membrane protein YlbJ
K05K4_RS19140	COG0739	heme binding
K05K4_RS19145	COG5001	Diguanylate cyclase
K05K4_RS19150	COG0583	DNA-binding transcription factor activity
K05K4_RS19155	COG2814	Major facilitator Superfamily
K05K4_RS19175	COG0697	spore germination
K05K4_RS19190	COG0179	Fumarylacetoacetate (FAA) hydrolase
K05K4_RS19210	COG1280	lysine exporter protein (LysE YggA)
K05K4_RS19220	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K05K4_RS19225	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K05K4_RS19230	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K05K4_RS19235	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
K05K4_RS19240	COG1845	cytochrome c oxidase, subunit III
K05K4_RS19260	COG1612	heme a metabolic process
K05K4_RS19265	COG0109	protoheme IX farnesyltransferase activity
K05K4_RS19270	COG0545	Peptidyl-prolyl cis-trans isomerase
K05K4_RS19300	COG1278	Cold shock
K05K4_RS19305	COG3036	rescue of stalled ribosome
K05K4_RS19310	COG2199	diguanylate cyclase activity
K05K4_RS19325	COG1132	(ABC) transporter
K05K4_RS19330	COG1132	(ABC) transporter
K05K4_RS19335	COG1538	Outer membrane efflux protein
K05K4_RS19340	COG2205	protein histidine kinase activity
K05K4_RS19340	COG0784	Response regulator, receiver
K05K4_RS19365	COG0840	transmembrane signaling receptor activity
K05K4_RS19370	COG0783	Belongs to the Dps family
K05K4_RS19380	COG2133	pyrroloquinoline quinone binding
K05K4_RS19385	COG1454	alcohol dehydrogenase
K05K4_RS19390	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
K05K4_RS19410	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K05K4_RS19415	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K05K4_RS19420	COG3186	Phenylalanine-4-hydroxylase
K05K4_RS19445	COG3530	Putative quorum-sensing-regulated virulence factor
K05K4_RS19465	COG0513	Belongs to the DEAD box helicase family
K05K4_RS19470	COG4628	conserved protein (DUF2132)
K05K4_RS19480	COG0133	tryptophan synthase activity
K05K4_RS19490	COG1278	Cold shock
K05K4_RS19500	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
K05K4_RS19510	COG0523	cobalamin synthesis protein
K05K4_RS19515	COG0513	Belongs to the DEAD box helicase family
K05K4_RS19535	COG2200	EAL domain
K05K4_RS19540	COG1119	ATPase activity
K05K4_RS19575	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
K05K4_RS19580	COG0513	Belongs to the DEAD box helicase family
K05K4_RS19595	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K05K4_RS19605	COG1073	alpha beta
K05K4_RS19610	COG1073	alpha beta
K05K4_RS19625	COG0730	response to heat
K05K4_RS19645	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K05K4_RS19655	COG0523	cobalamin synthesis protein
K05K4_RS19660	COG2988	succinylglutamate desuccinylase activity
K05K4_RS19665	COG0739	heme binding
K05K4_RS19675	COG0523	cobalamin synthesis protein
K05K4_RS19695	COG2095	MarC family integral membrane protein
K05K4_RS19720	COG1024	Enoyl-CoA hydratase
K05K4_RS19725	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K05K4_RS19730	COG1960	acyl-CoA dehydrogenase activity
K05K4_RS19740	COG0183	Belongs to the thiolase family
K05K4_RS19755	COG1024	Enoyl-CoA hydratase
K05K4_RS19760	COG1024	Enoyl-CoA hydratase
K05K4_RS19770	COG1028	Short-chain dehydrogenase reductase Sdr
K05K4_RS19775	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K05K4_RS19780	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K05K4_RS19785	COG1845	cytochrome c oxidase, subunit III
K05K4_RS19790	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
K05K4_RS19795	COG0109	protoheme IX farnesyltransferase activity
K05K4_RS19800	COG1902	pentaerythritol trinitrate reductase activity
K05K4_RS19800	COG0446	pyridine nucleotide-disulphide oxidoreductase
K05K4_RS19815	COG1012	belongs to the aldehyde dehydrogenase family
K05K4_RS19825	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K05K4_RS19855	COG1126	abc transporter atp-binding protein
K05K4_RS19860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K05K4_RS19865	COG4215	(ABC) transporter
K05K4_RS19870	COG4160	amino acid transport
K05K4_RS19935	COG0443	Heat shock 70 kDa protein
K05K4_RS19940	COG2847	Copper chaperone PCu(A)C
K05K4_RS20005	COG0814	amino acid
K05K4_RS20015	COG0243	molybdopterin cofactor binding
K05K4_RS20045	COG1116	anion transmembrane transporter activity
K05K4_RS20045	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K05K4_RS20050	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K05K4_RS20055	COG1116	anion transmembrane transporter activity
K05K4_RS20060	COG2146	nitrite reductase [NAD(P)H] activity
K05K4_RS20060	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K05K4_RS20110	COG0515	serine threonine protein kinase
K05K4_RS20110	COG2815	serine threonine protein kinase
K05K4_RS20145	COG0631	protein serine/threonine phosphatase activity
K05K4_RS20215	COG0420	3'-5' exonuclease activity
K05K4_RS20220	COG0419	ATPase involved in DNA repair
K05K4_RS20230	COG3040	lipid binding
K05K4_RS20240	COG1288	antiporter activity
K05K4_RS20250	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
K05K4_RS20265	COG2425	protein containing a von Willebrand factor type A (vWA) domain
K05K4_RS20280	COG0583	DNA-binding transcription factor activity
K05K4_RS20285	COG0277	FAD linked oxidase domain protein
K05K4_RS20300	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K05K4_RS20340	COG2176	DNA-directed DNA polymerase activity
K05K4_RS20385	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
K05K4_RS20390	COG1328	CTP reductase activity
K05K4_RS20595	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K05K4_RS20620	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K05K4_RS20625	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K05K4_RS20635	COG2116	formate transmembrane transporter activity
K05K4_RS20655	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
K05K4_RS20695	COG3118	belongs to the thioredoxin family
K05K4_RS20700	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K05K4_RS20725	COG2271	Major facilitator Superfamily
K05K4_RS20730	COG3851	Histidine kinase
K05K4_RS20735	COG2197	response regulator
K05K4_RS20745	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K05K4_RS20750	COG0583	DNA-binding transcription factor activity
K05K4_RS20760	COG0243	molybdopterin cofactor binding
K05K4_RS20775	COG0384	phenazine biosynthesis protein PhzF
K05K4_RS20780	COG1794	racemase activity, acting on amino acids and derivatives
K05K4_RS20810	COG1328	CTP reductase activity
K05K4_RS20815	COG0602	queuosine metabolic process
K05K4_RS20820	COG0534	Mate efflux family protein
K05K4_RS20825	COG2207	Transcriptional regulator
K05K4_RS20835	COG0189	ligase activity
K05K4_RS20835	COG4067	protein conserved in archaea
K05K4_RS20845	COG3111	PFAM Bacterial OB fold (BOF) protein
K05K4_RS20855	COG0725	ABC transporter, periplasmic molybdate-binding protein
K05K4_RS20860	COG4149	molybdate abc transporter
K05K4_RS20865	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
K05K4_RS20875	COG2203	Gaf domain
K05K4_RS20875	COG5001	Diguanylate cyclase
K05K4_RS20875	COG3706	GGDEF domain
K05K4_RS20875	COG4251	negative regulation of phosphorylation
K05K4_RS20895	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
K05K4_RS20900	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
K05K4_RS20925	COG3140	Belongs to the UPF0181 family
K05K4_RS20940	COG0583	DNA-binding transcription factor activity
K05K4_RS21100	COG0023	Translation Initiation Factor
K05K4_RS21110	COG1181	Belongs to the D-alanine--D-alanine ligase family
K05K4_RS21125	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K05K4_RS21125	COG1042	CoA-binding domain protein
K05K4_RS21125	COG0045	succinate-CoA ligase (ADP-forming) activity
K05K4_RS21130	COG0583	DNA-binding transcription factor activity
K05K4_RS21150	COG3447	MASE1 domain protein
K05K4_RS21150	COG5001	Diguanylate cyclase
K05K4_RS21150	COG5002	protein histidine kinase activity
K05K4_RS21155	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
K05K4_RS21165	COG1984	allophanate hydrolase subunit 2
K05K4_RS21175	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
K05K4_RS21180	COG4181	ATPase activity
K05K4_RS21190	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K05K4_RS21195	COG5001	Diguanylate cyclase
K05K4_RS21195	COG3300	MHYT domain
K05K4_RS21230	COG4533	DNA binding
K05K4_RS21240	COG2050	protein possibly involved in aromatic compounds catabolism
K05K4_RS21255	COG2067	long-chain fatty acid transport protein
K05K4_RS21260	COG2267	carboxylic ester hydrolase activity
K05K4_RS21280	COG0861	Integral membrane protein TerC family
K05K4_RS21285	COG0737	Belongs to the 5'-nucleotidase family
K05K4_RS21290	COG3593	DNA synthesis involved in DNA repair
K05K4_RS21300	COG0583	DNA-binding transcription factor activity
K05K4_RS21305	COG2116	formate transmembrane transporter activity
K05K4_RS21310	COG2353	YceI-like domain
K05K4_RS21315	COG3038	cytochrome b561
K05K4_RS21335	COG0513	Belongs to the DEAD box helicase family
K05K4_RS21340	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
K05K4_RS21350	COG0840	transmembrane signaling receptor activity
K05K4_RS21360	COG0546	phosphoglycolate phosphatase activity
K05K4_RS21375	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K05K4_RS21380	COG2759	Belongs to the formate--tetrahydrofolate ligase family
K05K4_RS21385	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K05K4_RS21400	COG2207	Transcriptional regulator
K05K4_RS21405	COG1979	alcohol dehydrogenase
K05K4_RS21415	COG1126	abc transporter atp-binding protein
K05K4_RS21420	COG0765	amino acid transport
K05K4_RS21425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K05K4_RS21430	COG0765	amino acid transport
K05K4_RS21435	COG2203	Gaf domain
K05K4_RS21435	COG2199	diguanylate cyclase activity
K05K4_RS21435	COG2200	EAL domain
K05K4_RS21450	COG1609	Transcriptional regulator
K05K4_RS21455	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K05K4_RS21455	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K05K4_RS21460	COG1105	Belongs to the carbohydrate kinase PfkB family
K05K4_RS21465	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
K05K4_RS21465	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K05K4_RS21465	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K05K4_RS21495	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K05K4_RS21505	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K05K4_RS21510	COG0509	glycine decarboxylation via glycine cleavage system
K05K4_RS21520	COG0346	lactoylglutathione lyase activity
K05K4_RS21530	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K05K4_RS21535	COG0583	DNA-binding transcription factor activity
K05K4_RS21540	COG0697	spore germination
K05K4_RS21545	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K05K4_RS21575	COG2176	DNA-directed DNA polymerase activity
K05K4_RS21615	COG0242	peptide deformylase activity
K05K4_RS21650	COG2239	Acts as a magnesium transporter
K05K4_RS21670	COG0346	lactoylglutathione lyase activity
K05K4_RS21675	COG1902	pentaerythritol trinitrate reductase activity
K05K4_RS21685	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K05K4_RS21685	COG2755	lipolytic protein G-D-S-L family
K05K4_RS21695	COG5642	Protein of unknown function (DUF2384)
K05K4_RS21700	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
K05K4_RS21735	COG2076	Multidrug Resistance protein
K05K4_RS21755	COG2962	Rard protein
K05K4_RS21770	COG0835	chemotaxis
K05K4_RS21770	COG0784	Response regulator, receiver
K05K4_RS21780	COG2197	response regulator
K05K4_RS21790	COG3706	GGDEF domain
K05K4_RS21795	COG2197	response regulator
K05K4_RS21800	COG3300	MHYT domain
K05K4_RS21800	COG5001	Diguanylate cyclase
K05K4_RS21805	COG0784	Response regulator, receiver
K05K4_RS21805	COG2205	protein histidine kinase activity
K05K4_RS21810	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
K05K4_RS21830	COG0456	acetyltransferase
K05K4_RS21830	COG1214	PFAM Peptidase M22, glycoprotease
K05K4_RS21840	COG3069	C4-dicarboxylate transmembrane transporter activity
K05K4_RS21865	COG3111	PFAM Bacterial OB fold (BOF) protein
K05K4_RS21870	COG1597	lipid kinase activity
K05K4_RS21875	COG0583	DNA-binding transcription factor activity
K05K4_RS21880	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K05K4_RS21910	COG0714	Associated with various cellular activities
K05K4_RS21915	COG0641	radical SAM
K05K4_RS21920	COG3119	arylsulfatase activity
K05K4_RS21930	COG3119	arylsulfatase activity
K05K4_RS21935	COG0745	RESPONSE REGULATOR receiver
K05K4_RS21950	COG2205	protein histidine kinase activity
K05K4_RS21950	COG0784	Response regulator, receiver
K05K4_RS21950	COG2198	Histidine kinase
K05K4_RS21955	COG1879	ABC-type sugar transport system periplasmic component
K05K4_RS21960	COG1803	Methylglyoxal synthase
K05K4_RS21965	COG0210	DNA helicase
K05K4_RS21970	COG1289	transmembrane transporter activity
K05K4_RS22005	COG4771	TonB-dependent receptor
K05K4_RS22005	COG1629	transport
K05K4_RS22015	COG0789	Transcriptional regulator
K05K4_RS22020	COG4604	ABC transporter, ATP-binding protein
K05K4_RS22025	COG4605	iron ion homeostasis
K05K4_RS22030	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K05K4_RS22035	COG4607	ABC-type enterochelin transport system periplasmic component
K05K4_RS22045	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
K05K4_RS22060	COG1609	Transcriptional regulator
K05K4_RS22065	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K05K4_RS22070	COG1879	ABC-type sugar transport system periplasmic component
K05K4_RS22075	COG1172	Belongs to the binding-protein-dependent transport system permease family
K05K4_RS22080	COG1129	ABC transporter
K05K4_RS22085	COG1869	D-ribose catabolic process
K05K4_RS22090	COG5001	Diguanylate cyclase
K05K4_RS22145	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K05K4_RS22155	COG2205	protein histidine kinase activity
K05K4_RS22155	COG0784	Response regulator, receiver
K05K4_RS22170	COG0330	HflC and HflK could
K05K4_RS22185	COG0517	IMP dehydrogenase activity
K05K4_RS22185	COG4175	Glycine betaine
K05K4_RS22190	COG4176	ABC-type proline glycine betaine transport system permease component
K05K4_RS22205	COG1012	belongs to the aldehyde dehydrogenase family
K05K4_RS22210	COG1309	transcriptional regulator
K05K4_RS22220	COG1028	Short-chain dehydrogenase reductase Sdr
K05K4_RS22235	COG1024	Enoyl-CoA hydratase
K05K4_RS22240	COG1960	acyl-CoA dehydrogenase activity
K05K4_RS22250	COG0183	Belongs to the thiolase family
K05K4_RS22260	COG1960	acyl-CoA dehydrogenase activity
K05K4_RS22265	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K05K4_RS22275	COG4770	biotin carboxylase activity
K05K4_RS22290	COG3264	Mechanosensitive ion channel
K05K4_RS22290	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K05K4_RS22300	COG0110	maltose O-acetyltransferase activity
K05K4_RS22305	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K05K4_RS22310	COG1271	oxidase subunit
K05K4_RS22315	COG1294	oxidase, subunit
K05K4_RS22325	COG0384	phenazine biosynthesis protein PhzF
K05K4_RS22345	COG3527	Alpha-acetolactate decarboxylase
K05K4_RS22355	COG1028	Short-chain dehydrogenase reductase Sdr
K05K4_RS22360	COG0500	methyltransferase
K05K4_RS22390	COG1022	Amp-dependent synthetase and ligase
K05K4_RS22420	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K05K4_RS22425	COG1263	PTS System
K05K4_RS22425	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K05K4_RS22430	COG1486	melibiose metabolic process
K05K4_RS22435	COG2188	Transcriptional regulator
K05K4_RS22440	COG1320	monovalent cation:proton antiporter activity
K05K4_RS22445	COG2212	antiporter activity
K05K4_RS22450	COG1863	multisubunit Na H antiporter MnhE subunit
K05K4_RS22455	COG0651	ATP synthesis coupled electron transport
K05K4_RS22460	COG1006	Multisubunit Na H antiporter MnhC subunit
K05K4_RS22465	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K05K4_RS22465	COG2111	Na H antiporter
K05K4_RS22475	COG0589	response to stress
K05K4_RS22480	COG4221	oxidoreductase activity
K05K4_RS22485	COG0583	DNA-binding transcription factor activity
K05K4_RS22495	COG2814	Major facilitator Superfamily
K05K4_RS22560	COG1522	sequence-specific DNA binding
K05K4_RS22595	COG0515	serine threonine protein kinase
K05K4_RS22620	COG3501	Rhs element vgr protein
K05K4_RS22635	COG2204	response regulator
K05K4_RS22660	COG0739	heme binding
K05K4_RS22675	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K05K4_RS22725	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
K05K4_RS22735	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
K05K4_RS22735	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
K05K4_RS22750	COG4989	oxidoreductase activity
K05K4_RS22765	COG0038	chloride channel
K05K4_RS22800	COG2897	thiosulfate sulfurtransferase activity
K05K4_RS22820	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K05K4_RS22825	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K05K4_RS22830	COG0840	transmembrane signaling receptor activity
K05K4_RS22835	COG2814	Major facilitator Superfamily
K05K4_RS22840	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K05K4_RS22855	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K05K4_RS22865	COG0840	transmembrane signaling receptor activity
K05K4_RS22885	COG2195	Cleaves the N-terminal amino acid of tripeptides
K05K4_RS22900	COG2197	response regulator
K05K4_RS22905	COG3850	Histidine kinase
K05K4_RS22910	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K05K4_RS22920	COG0243	molybdopterin cofactor binding
K05K4_RS22930	COG3005	denitrification pathway
K05K4_RS22940	COG3243	poly(R)-hydroxyalkanoic acid synthase
K05K4_RS22950	COG0183	Belongs to the thiolase family
K05K4_RS22960	COG1280	lysine exporter protein (LysE YggA)
K05K4_RS22970	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K05K4_RS22975	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K05K4_RS23030	COG1846	Transcriptional regulator
K05K4_RS23035	COG2205	protein histidine kinase activity
K05K4_RS23035	COG0784	Response regulator, receiver
K05K4_RS23040	COG1879	ABC-type sugar transport system periplasmic component
K05K4_RS23050	COG2827	Endonuclease containing a URI domain
K05K4_RS23055	COG3132	Protein of unknown function, DUF480
K05K4_RS23075	COG5002	protein histidine kinase activity
K05K4_RS23075	COG2205	protein histidine kinase activity
K05K4_RS23075	COG0784	Response regulator, receiver
K05K4_RS23100	COG0583	DNA-binding transcription factor activity
K05K4_RS23115	COG0531	amino acid
K05K4_RS23130	COG2205	protein histidine kinase activity
K05K4_RS23135	COG0745	RESPONSE REGULATOR receiver
K05K4_RS23165	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K05K4_RS23170	COG2239	Acts as a magnesium transporter
K05K4_RS23175	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
K05K4_RS23180	COG0402	S-adenosylhomocysteine deaminase activity
K05K4_RS23185	COG1418	mRNA catabolic process
K05K4_RS23200	COG2814	Major facilitator Superfamily
K05K4_RS23210	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K05K4_RS23230	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K05K4_RS23245	COG0745	RESPONSE REGULATOR receiver
K05K4_RS23250	COG2205	protein histidine kinase activity
K05K4_RS23260	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K05K4_RS23265	COG2194	sulfuric ester hydrolase activity
K05K4_RS23285	COG4667	esterase of the alpha-beta hydrolase superfamily
K05K4_RS23290	COG1741	Belongs to the pirin family
K05K4_RS23295	COG1278	Cold shock
K05K4_RS23310	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K05K4_RS23315	COG0678	peroxiredoxin activity
K05K4_RS23315	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K05K4_RS23325	COG1686	Belongs to the peptidase S11 family
K05K4_RS23335	COG0625	glutathione transferase activity
K05K4_RS23345	COG1621	beta-fructofuranosidase activity
K05K4_RS23350	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K05K4_RS23355	COG1263	PTS System
K05K4_RS23355	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K05K4_RS23375	COG1028	Short-chain dehydrogenase reductase Sdr
K05K4_RS23390	COG3746	phosphate-selective porin O and P
K05K4_RS23405	COG0300	oxidoreductase activity
K05K4_RS23410	COG0583	DNA-binding transcription factor activity
K05K4_RS23415	COG2207	Transcriptional regulator
K05K4_RS23415	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K05K4_RS23420	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K05K4_RS23450	COG0513	Belongs to the DEAD box helicase family
K05K4_RS23460	COG0583	DNA-binding transcription factor activity
K05K4_RS23475	COG1902	pentaerythritol trinitrate reductase activity
K05K4_RS23480	COG1063	alcohol dehydrogenase
K05K4_RS23490	COG1028	Short-chain dehydrogenase reductase Sdr
K05K4_RS23500	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K05K4_RS23505	COG0006	proline dipeptidase activity
K05K4_RS23510	COG3608	succinylglutamate desuccinylase aspartoacylase
K05K4_RS23515	COG1522	sequence-specific DNA binding
K05K4_RS23520	COG1012	belongs to the aldehyde dehydrogenase family
K05K4_RS23525	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K05K4_RS23530	COG3122	Protein conserved in bacteria
K05K4_RS23545	COG0583	DNA-binding transcription factor activity
K05K4_RS23550	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K05K4_RS23555	COG0252	asparaginase activity
K05K4_RS23560	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
K05K4_RS23575	COG2197	response regulator
K05K4_RS23580	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K05K4_RS23605	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K05K4_RS23635	COG3842	ATPase activity
K05K4_RS23655	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K05K4_RS23690	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K05K4_RS23725	COG0583	DNA-binding transcription factor activity
K05K4_RS23735	COG4948	Mandelate Racemase Muconate Lactonizing
K05K4_RS23770	COG1342	Belongs to the UPF0251 family
K05K4_RS23775	COG4176	ABC-type proline glycine betaine transport system permease component
K05K4_RS23780	COG4175	Glycine betaine
K05K4_RS23780	COG3448	diguanylate cyclase activity
K05K4_RS23785	COG3015	lipoprotein NlpE involved in copper resistance
K05K4_RS23790	COG3713	MltA-interacting MipA family protein
K05K4_RS23805	COG0583	DNA-binding transcription factor activity
K05K4_RS23830	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
K05K4_RS23840	COG1335	isochorismatase
K05K4_RS23855	COG1349	DNA-binding transcription factor activity
K05K4_RS23865	COG2070	2-Nitropropane dioxygenase
K05K4_RS23870	COG0531	amino acid
K05K4_RS23875	COG4302	ethanolamine ammonia-lyase activity
K05K4_RS23880	COG4303	Ethanolamine ammonia lyase large subunit
K05K4_RS23890	COG1309	transcriptional regulator
K05K4_RS23910	COG1280	lysine exporter protein (LysE YggA)
K05K4_RS23920	COG0459	protein refolding
K05K4_RS23925	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
K05K4_RS23935	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K05K4_RS23950	COG1304	FMN binding
K05K4_RS23975	COG1256	bacterial-type flagellum assembly
K05K4_RS23975	COG4786	Flagellar basal body rod
K05K4_RS23985	COG1706	bacterial-type flagellum-dependent cell motility
K05K4_RS23990	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
K05K4_RS23995	COG4786	Flagellar basal body rod
K05K4_RS24000	COG4787	bacterial-type flagellum-dependent cell motility
K05K4_RS24015	COG1558	bacterial-type flagellum-dependent cell motility
K05K4_RS24020	COG1815	bacterial-type flagellum-dependent cell motility
K05K4_RS24040	COG0741	lytic transglycosylase activity
K05K4_RS24045	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K05K4_RS24065	COG1760	l-serine dehydratase
K05K4_RS24080	COG0583	DNA-binding transcription factor activity
K05K4_RS24090	COG2866	Carboxypeptidase
K05K4_RS24095	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K05K4_RS24105	COG2990	Protein conserved in bacteria
K05K4_RS24130	COG3842	ATPase activity
K05K4_RS24135	COG1840	ABC-type Fe3 transport system, periplasmic component
K05K4_RS24145	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K05K4_RS24155	COG1609	Transcriptional regulator
K05K4_RS24185	COG3240	lipase activity
K05K4_RS24190	COG1309	transcriptional regulator
K05K4_RS24205	COG1136	(ABC) transporter
K05K4_RS24205	COG0577	efflux transmembrane transporter activity
K05K4_RS24210	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K05K4_RS24215	COG2067	long-chain fatty acid transport protein
K05K4_RS24225	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
K05K4_RS24240	COG1011	Hydrolase
K05K4_RS24280	COG0110	maltose O-acetyltransferase activity
K05K4_RS24285	COG1765	OsmC-like protein
K05K4_RS24290	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K05K4_RS24290	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K05K4_RS24305	COG3046	protein related to deoxyribodipyrimidine photolyase
K05K4_RS24310	COG0415	Belongs to the DNA photolyase family
K05K4_RS24315	COG3706	GGDEF domain
K05K4_RS24330	COG3706	GGDEF domain
K05K4_RS24345	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K05K4_RS24365	COG3033	Beta-eliminating lyase
K05K4_RS24375	COG1271	oxidase subunit
K05K4_RS24380	COG1294	oxidase, subunit
K05K4_RS24400	COG3179	chitinase
K05K4_RS24405	COG0579	oxidoreductase
K05K4_RS24430	COG3706	GGDEF domain
K05K4_RS24460	COG0583	DNA-binding transcription factor activity
K05K4_RS24485	COG0189	ligase activity
K05K4_RS24490	COG0189	ligase activity
K05K4_RS24490	COG4067	protein conserved in archaea
K05K4_RS24500	COG1166	arginine decarboxylase activity
K05K4_RS24505	COG0010	Belongs to the arginase family
K05K4_RS24510	COG2814	Major facilitator Superfamily
K05K4_RS24515	COG1770	oligopeptidase
K05K4_RS24530	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K05K4_RS24535	COG1121	(ABC) transporter
K05K4_RS24540	COG0803	Belongs to the bacterial solute-binding protein 9 family
K05K4_RS24580	COG0848	biopolymer transport protein
K05K4_RS24585	COG0811	peptide transport
K05K4_RS24590	COG0811	peptide transport
K05K4_RS24610	COG0745	RESPONSE REGULATOR receiver
K05K4_RS24615	COG0584	glycerophosphoryl diester phosphodiesterase
K05K4_RS24625	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K05K4_RS24690	COG0312	modulator of DNA gyrase
K05K4_RS24695	COG0312	modulator of DNA gyrase
K05K4_RS24700	COG0351	phosphomethylpyrimidine kinase
K05K4_RS24705	COG1116	anion transmembrane transporter activity
K05K4_RS24710	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K05K4_RS24715	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K05K4_RS24720	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
K05K4_RS24740	COG0243	molybdopterin cofactor binding
K05K4_RS24745	COG3005	denitrification pathway
K05K4_RS24750	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K05K4_RS24755	COG1028	Short-chain dehydrogenase reductase Sdr
K05K4_RS24770	COG0456	acetyltransferase
K05K4_RS24790	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K05K4_RS24795	COG1929	Belongs to the glycerate kinase type-1 family
K05K4_RS24800	COG2610	gluconate transmembrane transporter activity
K05K4_RS24805	COG3835	regulator
K05K4_RS24865	COG3047	cAMP biosynthetic process
K05K4_RS24870	COG1357	PFAM Pentapeptide repeats (8 copies)
K05K4_RS24900	COG2375	cellular response to nickel ion
K05K4_RS24905	COG0583	DNA-binding transcription factor activity
K05K4_RS24910	COG2162	N-hydroxyarylamine O-acetyltransferase activity
K05K4_RS24915	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
K05K4_RS24930	COG2199	diguanylate cyclase activity
K05K4_RS24940	COG0561	phosphatase activity
K05K4_RS24945	COG0583	DNA-binding transcription factor activity
K05K4_RS24960	COG0564	pseudouridine synthase activity
K05K4_RS24965	COG0534	Mate efflux family protein
K05K4_RS24980	COG3123	guanosine phosphorylase activity
K05K4_RS24995	COG0596	Alpha beta hydrolase
K05K4_RS25020	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K05K4_RS25030	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K05K4_RS25035	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K05K4_RS25035	COG2169	Transcriptional regulator
K05K4_RS25045	COG2259	Doxx family
K05K4_RS25050	COG1741	Belongs to the pirin family
K05K4_RS25070	COG0363	glucosamine-6-phosphate deaminase activity
K05K4_RS25080	COG0786	glutamate:sodium symporter activity
K05K4_RS25085	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K05K4_RS25090	COG1131	(ABC) transporter
K05K4_RS25100	COG0786	glutamate:sodium symporter activity
K05K4_RS25125	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K05K4_RS25135	COG3279	Response regulator of the LytR AlgR family
K05K4_RS25140	COG3275	phosphorelay sensor kinase activity
K05K4_RS25170	COG0772	Belongs to the SEDS family
K05K4_RS25195	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
K05K4_RS25195	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K05K4_RS25205	COG0444	Belongs to the ABC transporter superfamily
K05K4_RS25210	COG4608	Belongs to the ABC transporter superfamily
K05K4_RS25655	COG0358	DNA primase activity
K05K4_RS25960	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K05K4_RS26145	COG2916	Histone family protein nucleoid-structuring protein H-NS
K05K4_RS26415	COG0330	HflC and HflK could
K05K4_RS26420	COG0330	HflC and HflK could
K05K4_RS26465	COG2203	Gaf domain
K05K4_RS26465	COG3706	GGDEF domain
K05K4_RS26465	COG4251	negative regulation of phosphorylation
K05K4_RS26465	COG5001	Diguanylate cyclase
K05K4_RS26575	COG0358	DNA primase activity