locus-tag	class	description
K08M4_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K08M4_RS00010	COG0592	DNA-directed DNA polymerase activity
K08M4_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K08M4_RS00020	COG0187	DNA topoisomerase II activity
K08M4_RS00025	COG0071	Belongs to the small heat shock protein (HSP20) family
K08M4_RS00030	COG3977	Valine--pyruvate aminotransferase
K08M4_RS00035	COG0751	glycine-tRNA ligase activity
K08M4_RS00040	COG0752	glycyl-tRNA synthetase alpha subunit
K08M4_RS00045	COG2119	membrane
K08M4_RS00055	COG0425	Belongs to the sulfur carrier protein TusA family
K08M4_RS00070	COG0604	alcohol dehydrogenase
K08M4_RS00075	COG0183	Belongs to the thiolase family
K08M4_RS00080	COG1250	3-hydroxyacyl-CoA dehydrogenase
K08M4_RS00080	COG1024	Enoyl-CoA hydratase
K08M4_RS00085	COG1739	Uncharacterized protein family UPF0029
K08M4_RS00090	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K08M4_RS00095	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
K08M4_RS00140	COG3335	DDE superfamily endonuclease
K08M4_RS00150	COG2132	Multicopper oxidase
K08M4_RS00160	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
K08M4_RS00165	COG0352	thiamine-phosphate diphosphorylase activity
K08M4_RS00170	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K08M4_RS00175	COG2104	thiamine diphosphate biosynthetic process
K08M4_RS00180	COG2022	thiamine diphosphate biosynthetic process
K08M4_RS00190	COG0006	proline dipeptidase activity
K08M4_RS00190	COG0006	proline dipeptidase activity
K08M4_RS00220	COG3220	belongs to the UPF0276 family
K08M4_RS00230	COG0210	DNA helicase
K08M4_RS00240	COG0405	Gamma-glutamyltransferase
K08M4_RS00245	COG1280	lysine exporter protein (LysE YggA)
K08M4_RS00255	COG2962	Rard protein
K08M4_RS00260	COG0514	ATP-dependent DNA helicase (RecQ)
K08M4_RS00270	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
K08M4_RS00275	COG0248	Ppx GppA phosphatase
K08M4_RS00280	COG0513	Belongs to the DEAD box helicase family
K08M4_RS00285	COG3118	belongs to the thioredoxin family
K08M4_RS00300	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
K08M4_RS00305	COG2871	sodium ion transport
K08M4_RS00365	COG3335	DDE superfamily endonuclease
K08M4_RS00375	COG3335	DDE superfamily endonuclease
K08M4_RS00385	COG3071	HemY protein
K08M4_RS00390	COG2959	enzyme of heme biosynthesis
K08M4_RS00395	COG1587	Uroporphyrinogen-III synthase
K08M4_RS00400	COG0181	hydroxymethylbilane synthase activity
K08M4_RS00405	COG3072	Adenylate cyclase
K08M4_RS00410	COG1965	Belongs to the frataxin family
K08M4_RS00420	COG0019	diaminopimelate decarboxylase activity
K08M4_RS00425	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
K08M4_RS00435	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
K08M4_RS00440	COG1011	Hydrolase
K08M4_RS00445	COG2199	diguanylate cyclase activity
K08M4_RS00445	COG3287	FIST C domain
K08M4_RS00445	COG2200	EAL domain
K08M4_RS00450	COG3287	FIST C domain
K08M4_RS00450	COG2199	diguanylate cyclase activity
K08M4_RS00450	COG2200	EAL domain
K08M4_RS00455	COG3148	PFAM DTW domain containing protein
K08M4_RS00470	COG0561	phosphatase activity
K08M4_RS00475	COG2267	carboxylic ester hydrolase activity
K08M4_RS00480	COG1280	lysine exporter protein (LysE YggA)
K08M4_RS00485	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
K08M4_RS00490	COG0640	Transcriptional regulator
K08M4_RS00495	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K08M4_RS00540	COG2095	MarC family integral membrane protein
K08M4_RS00550	COG0742	ribosomal rna small subunit methyltransferase
K08M4_RS00555	COG0552	protein localization to endoplasmic reticulum
K08M4_RS00560	COG2884	Cell division ATP-binding protein ftsE
K08M4_RS00565	COG2177	Part of the ABC transporter FtsEX involved in
K08M4_RS00575	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K08M4_RS00580	COG0705	Rhomboid family
K08M4_RS00585	COG1580	Controls the rotational direction of flagella during chemotaxis
K08M4_RS00590	COG3161	chorismate lyase activity
K08M4_RS00595	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
K08M4_RS00600	COG2937	Belongs to the GPAT DAPAT family
K08M4_RS00605	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K08M4_RS00610	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K08M4_RS00615	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
K08M4_RS00620	COG0534	Mate efflux family protein
K08M4_RS00625	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K08M4_RS00645	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K08M4_RS00655	COG4206	TonB-dependent receptor
K08M4_RS00665	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
K08M4_RS00730	COG3335	DDE superfamily endonuclease
K08M4_RS00740	COG3335	DDE superfamily endonuclease
K08M4_RS00750	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K08M4_RS00760	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K08M4_RS00770	COG1072	(Pantothenic acid kinase))
K08M4_RS00800	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K08M4_RS00805	COG0250	Participates in transcription elongation, termination and antitermination
K08M4_RS00815	COG0081	regulation of translation
K08M4_RS00820	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K08M4_RS00825	COG0222	ribosome binding
K08M4_RS00840	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
K08M4_RS00845	COG2816	NAD+ diphosphatase activity
K08M4_RS00855	COG1573	uracil-dna glycosylase
K08M4_RS00865	COG3068	Protein conserved in bacteria
K08M4_RS00870	COG1253	flavin adenine dinucleotide binding
K08M4_RS00885	COG0151	Belongs to the GarS family
K08M4_RS00890	COG0138	bifunctional purine biosynthesis protein purh
K08M4_RS00895	COG0789	Transcriptional regulator
K08M4_RS00900	COG2199	diguanylate cyclase activity
K08M4_RS00905	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
K08M4_RS00910	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K08M4_RS00915	COG2264	protein methyltransferase activity
K08M4_RS00920	COG0439	Biotin carboxylase
K08M4_RS00925	COG0511	ligase activity, forming carbon-carbon bonds
K08M4_RS00930	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K08M4_RS00935	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K08M4_RS00950	COG2814	Major facilitator Superfamily
K08M4_RS00955	COG2198	Histidine kinase
K08M4_RS00955	COG0784	Response regulator, receiver
K08M4_RS00955	COG2205	protein histidine kinase activity
K08M4_RS00970	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K08M4_RS00980	COG3263	regulation of cellular component size
K08M4_RS00990	COG4232	protein-disulfide reductase activity
K08M4_RS00995	COG1438	arginine binding
K08M4_RS01000	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
K08M4_RS01005	COG0540	Belongs to the ATCase OTCase family
K08M4_RS01015	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
K08M4_RS01030	COG1288	antiporter activity
K08M4_RS01035	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
K08M4_RS01040	COG1027	Aspartate ammonia-lyase
K08M4_RS01050	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
K08M4_RS01060	COG2205	protein histidine kinase activity
K08M4_RS01065	COG0745	RESPONSE REGULATOR receiver
K08M4_RS01075	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
K08M4_RS01095	COG3152	Membrane
K08M4_RS01110	COG1494	fructose-1,6-bisphosphatase
K08M4_RS01115	COG3074	FtsZ-dependent cytokinesis
K08M4_RS01120	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K08M4_RS01125	COG1575	Belongs to the MenA family. Type 1 subfamily
K08M4_RS01130	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K08M4_RS01135	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
K08M4_RS01145	COG1609	Transcriptional regulator
K08M4_RS01150	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K08M4_RS01155	COG0254	rRNA binding
K08M4_RS01160	COG0281	malic enzyme
K08M4_RS01165	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
K08M4_RS01170	COG0626	cystathionine gamma-synthase activity
K08M4_RS01175	COG0460	homoserine dehydrogenase
K08M4_RS01175	COG0527	aspartate kinase activity
K08M4_RS01180	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K08M4_RS01190	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
K08M4_RS01195	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K08M4_RS01200	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
K08M4_RS01215	COG0165	Argininosuccinate lyase
K08M4_RS01215	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
K08M4_RS01225	COG0251	oxidation-reduction process
K08M4_RS01230	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K08M4_RS01235	COG0678	peroxiredoxin activity
K08M4_RS01235	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K08M4_RS01250	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
K08M4_RS01285	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K08M4_RS01295	COG0338	D12 class N6 adenine-specific DNA methyltransferase
K08M4_RS01300	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K08M4_RS01305	COG0546	phosphoglycolate phosphatase activity
K08M4_RS01310	COG0180	Tryptophanyl-tRNA synthetase
K08M4_RS01325	COG0512	Glutamine amidotransferase of anthranilate synthase
K08M4_RS01330	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K08M4_RS01340	COG1012	belongs to the aldehyde dehydrogenase family
K08M4_RS01350	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K08M4_RS01355	COG3954	Phosphoribulokinase
K08M4_RS01360	COG3089	Belongs to the UPF0270 family
K08M4_RS01365	COG0429	hydrolase of the alpha beta-hydrolase fold
K08M4_RS01375	COG0488	(ABC) transporter
K08M4_RS01380	COG2249	NAD(P)H dehydrogenase (quinone) activity
K08M4_RS01395	COG1047	Peptidyl-prolyl cis-trans
K08M4_RS01400	COG1446	asparaginase
K08M4_RS01405	COG2900	Belongs to the SlyX family
K08M4_RS01415	COG0545	Peptidyl-prolyl cis-trans isomerase
K08M4_RS01420	COG2964	Protein conserved in bacteria
K08M4_RS01425	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
K08M4_RS01430	COG2923	Belongs to the DsrF TusC family
K08M4_RS01440	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
K08M4_RS01445	COG0049	tRNA binding
K08M4_RS01450	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K08M4_RS01465	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K08M4_RS01470	COG0088	Forms part of the polypeptide exit tunnel
K08M4_RS01475	COG0089	rRNA binding
K08M4_RS01480	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K08M4_RS01485	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K08M4_RS01495	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K08M4_RS01500	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
K08M4_RS01510	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K08M4_RS01515	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
K08M4_RS01520	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K08M4_RS01525	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K08M4_RS01530	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K08M4_RS01535	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K08M4_RS01540	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K08M4_RS01545	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
K08M4_RS01550	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
K08M4_RS01555	COG1841	ribosomal large subunit assembly
K08M4_RS01560	COG0200	Binds to the 23S rRNA
K08M4_RS01565	COG0201	protein transport
K08M4_RS01570	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K08M4_RS01575	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K08M4_RS01580	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K08M4_RS01585	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
K08M4_RS01590	COG0202	RNA polymerase activity
K08M4_RS01595	COG0203	ribosomal protein L17
K08M4_RS01605	COG0545	Peptidyl-prolyl cis-trans isomerase
K08M4_RS01610	COG3266	domain, Protein
K08M4_RS01610	COG3061	Opacity-associated protein A
K08M4_RS01620	COG2153	protein acetylation
K08M4_RS01660	COG0737	Belongs to the 5'-nucleotidase family
K08M4_RS01665	COG0175	sulfate reduction
K08M4_RS01670	COG2895	sulfate adenylyltransferase (ATP) activity
K08M4_RS01675	COG3273	potassium ion transport
K08M4_RS01675	COG0471	metal ion transport
K08M4_RS01680	COG0529	Catalyzes the synthesis of activated sulfate
K08M4_RS01715	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
K08M4_RS01725	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K08M4_RS01730	COG0729	surface antigen
K08M4_RS01740	COG2105	PFAM AIG2 family protein
K08M4_RS01745	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
K08M4_RS01750	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K08M4_RS01755	COG0163	prenyltransferase activity
K08M4_RS01760	COG4143	(ABC) transporter
K08M4_RS01765	COG1178	ABC-type Fe3 transport system permease component
K08M4_RS01770	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
K08M4_RS01775	COG3028	Belongs to the UPF0307 family
K08M4_RS01780	COG0312	modulator of DNA gyrase
K08M4_RS01785	COG2239	Acts as a magnesium transporter
K08M4_RS01790	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K08M4_RS01795	COG1660	Displays ATPase and GTPase activities
K08M4_RS01800	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K08M4_RS01805	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K08M4_RS01815	COG1137	ATPase activity
K08M4_RS01820	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
K08M4_RS01830	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
K08M4_RS01835	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
K08M4_RS01835	COG0517	IMP dehydrogenase activity
K08M4_RS01845	COG1127	ABC transporter
K08M4_RS01850	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K08M4_RS01855	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K08M4_RS01860	COG2854	intermembrane phospholipid transfer
K08M4_RS01870	COG5007	Belongs to the BolA IbaG family
K08M4_RS01875	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K08M4_RS01880	COG0204	Acyl-transferase
K08M4_RS01885	COG0251	oxidation-reduction process
K08M4_RS01890	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
K08M4_RS01920	COG0456	acetyltransferase
K08M4_RS01930	COG0525	valine-tRNA ligase activity
K08M4_RS01935	COG2927	DNA polymerase III (CHI subunit)
K08M4_RS01940	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K08M4_RS01945	COG0795	lipopolysaccharide-transporting ATPase activity
K08M4_RS01950	COG0795	lipopolysaccharide-transporting ATPase activity
K08M4_RS02060	COG0840	transmembrane signaling receptor activity
K08M4_RS02100	COG0741	lytic transglycosylase activity
K08M4_RS02105	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
K08M4_RS02120	COG2066	Belongs to the glutaminase family
K08M4_RS02125	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K08M4_RS02130	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
K08M4_RS02145	COG0762	integral membrane protein
K08M4_RS02150	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K08M4_RS02155	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K08M4_RS02170	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K08M4_RS02175	COG1678	Uncharacterized ACR, COG1678
K08M4_RS02180	COG0189	ligase activity
K08M4_RS02185	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K08M4_RS02195	COG2356	endonuclease I
K08M4_RS02200	COG3091	SprT-like family
K08M4_RS02220	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
K08M4_RS02260	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
K08M4_RS02265	COG0588	phosphoglycerate mutase activity
K08M4_RS02270	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K08M4_RS02280	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
K08M4_RS02285	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K08M4_RS02290	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K08M4_RS02305	COG5002	protein histidine kinase activity
K08M4_RS02305	COG2198	Histidine kinase
K08M4_RS02305	COG0784	Response regulator, receiver
K08M4_RS02330	COG0191	fructose-bisphosphate aldolase activity
K08M4_RS02335	COG0668	transmembrane transport
K08M4_RS02340	COG1279	arginine transmembrane transporter activity
K08M4_RS02355	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K08M4_RS02360	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
K08M4_RS02365	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K08M4_RS02375	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
K08M4_RS02380	COG3079	Belongs to the UPF0149 family
K08M4_RS02385	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K08M4_RS02390	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K08M4_RS02405	COG0354	folic acid binding
K08M4_RS02410	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
K08M4_RS02420	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
K08M4_RS02425	COG1595	DNA-templated transcription, initiation
K08M4_RS02445	COG0481	GTPase activity
K08M4_RS02455	COG0571	ribonuclease III activity
K08M4_RS02460	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K08M4_RS02465	COG1381	Involved in DNA repair and RecF pathway recombination
K08M4_RS02470	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
K08M4_RS02475	COG0736	holo-[acyl-carrier-protein] synthase activity
K08M4_RS02480	COG4999	Histidine kinase
K08M4_RS02480	COG3850	Histidine kinase
K08M4_RS02480	COG3437	response regulator, receiver
K08M4_RS02480	COG2205	protein histidine kinase activity
K08M4_RS02490	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K08M4_RS02495	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K08M4_RS02500	COG3956	TIGRFAM MazG family protein
K08M4_RS02505	COG0504	CTP synthase activity
K08M4_RS02510	COG0148	phosphopyruvate hydratase activity
K08M4_RS02515	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
K08M4_RS02520	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
K08M4_RS02530	COG0585	pseudouridine synthase activity
K08M4_RS02535	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
K08M4_RS02540	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K08M4_RS02550	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K08M4_RS02555	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K08M4_RS02560	COG1546	Belongs to the CinA family
K08M4_RS02565	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K08M4_RS02585	COG3833	ABC-type maltose transport systems, permease component
K08M4_RS02590	COG1175	transmembrane transport
K08M4_RS02595	COG2182	Extracellular solute-binding protein
K08M4_RS02605	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K08M4_RS02615	COG3842	ATPase activity
K08M4_RS02630	COG0527	aspartate kinase activity
K08M4_RS02635	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
K08M4_RS02690	COG3630	sodium ion export across plasma membrane
K08M4_RS02695	COG0511	ligase activity, forming carbon-carbon bonds
K08M4_RS02695	COG5016	pyruvate
K08M4_RS02700	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
K08M4_RS02710	COG1238	metal cluster binding
K08M4_RS02715	COG0612	Peptidase, M16
K08M4_RS02730	COG1854	S-ribosylhomocysteine lyase activity
K08M4_RS02735	COG4536	flavin adenine dinucleotide binding
K08M4_RS02740	COG4137	Cytochrome C assembly protein
K08M4_RS02745	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K08M4_RS02750	COG0228	four-way junction DNA binding
K08M4_RS02755	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K08M4_RS02760	COG0336	Belongs to the RNA methyltransferase TrmD family
K08M4_RS02765	COG0335	large ribosomal subunit rRNA binding
K08M4_RS02775	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
K08M4_RS02780	COG0237	dephospho-CoA kinase activity
K08M4_RS02790	COG1459	type II secretion system
K08M4_RS02795	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K08M4_RS02805	COG0157	Belongs to the NadC ModD family
K08M4_RS02820	COG2186	Transcriptional regulator
K08M4_RS02825	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
K08M4_RS02830	COG0508	dehydrogenase complex catalyzes the overall conversion of
K08M4_RS02835	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K08M4_RS02850	COG0288	reversible hydration of carbon dioxide
K08M4_RS02855	COG0659	secondary active sulfate transmembrane transporter activity
K08M4_RS02860	COG1131	(ABC) transporter
K08M4_RS02865	COG0842	Transport permease protein
K08M4_RS02870	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
K08M4_RS02875	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
K08M4_RS02880	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K08M4_RS02900	COG1489	DNA binding
K08M4_RS02905	COG1643	Atp-dependent helicase
K08M4_RS02910	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K08M4_RS02915	COG1752	Esterase of the alpha-beta hydrolase superfamily
K08M4_RS02920	COG1049	propionate catabolic process, 2-methylcitrate cycle
K08M4_RS02935	COG0004	ammonium transporteR
K08M4_RS02940	COG1840	ABC-type Fe3 transport system, periplasmic component
K08M4_RS02950	COG3842	ATPase activity
K08M4_RS02955	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K08M4_RS02970	COG2971	BadF BadG BcrA BcrD
K08M4_RS02980	COG4608	Belongs to the ABC transporter superfamily
K08M4_RS02985	COG0444	Belongs to the ABC transporter superfamily
K08M4_RS02990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K08M4_RS03000	COG0747	negative chemotaxis
K08M4_RS03010	COG2813	Specifically methylates the guanine in position
K08M4_RS03015	COG0628	permease
K08M4_RS03020	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
K08M4_RS03025	COG0316	Belongs to the HesB IscA family
K08M4_RS03040	COG0739	heme binding
K08M4_RS03045	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K08M4_RS03050	COG2239	Acts as a magnesium transporter
K08M4_RS03055	COG2027	D-alanyl-D-alanine carboxypeptidase
K08M4_RS03060	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K08M4_RS03065	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K08M4_RS03070	COG1534	Rna-binding protein
K08M4_RS03075	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
K08M4_RS03080	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K08M4_RS03085	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
K08M4_RS03090	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K08M4_RS03100	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K08M4_RS03115	COG0779	Required for maturation of 30S ribosomal subunits
K08M4_RS03120	COG0195	Participates in both transcription termination and antitermination
K08M4_RS03125	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K08M4_RS03130	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K08M4_RS03135	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K08M4_RS03140	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K08M4_RS03145	COG1185	polyribonucleotide nucleotidyltransferase activity
K08M4_RS03160	COG0534	Mate efflux family protein
K08M4_RS03165	COG0826	peptidase U32
K08M4_RS03170	COG0826	peptidase U32
K08M4_RS03180	COG3154	lipid carrier protein
K08M4_RS03185	COG3153	acetyltransferase
K08M4_RS03200	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
K08M4_RS03220	COG0084	hydrolase, TatD family'
K08M4_RS03225	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K08M4_RS03230	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
K08M4_RS03235	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
K08M4_RS03240	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
K08M4_RS03245	COG0813	purine-nucleoside phosphorylase activity
K08M4_RS03255	COG0560	Phosphoserine phosphatase
K08M4_RS03265	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
K08M4_RS03270	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K08M4_RS03300	COG4628	conserved protein (DUF2132)
K08M4_RS03325	COG1022	Amp-dependent synthetase and ligase
K08M4_RS03355	COG4964	Belongs to the GSP D family
K08M4_RS03415	COG2226	methyltransferase
K08M4_RS03420	COG2059	Chromate
K08M4_RS03425	COG0583	DNA-binding transcription factor activity
K08M4_RS03455	COG2195	Cleaves the N-terminal amino acid of tripeptides
K08M4_RS03460	COG2252	PERMEase
K08M4_RS03465	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
K08M4_RS03470	COG1073	alpha beta
K08M4_RS03485	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K08M4_RS03490	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K08M4_RS03495	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K08M4_RS03495	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K08M4_RS03515	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K08M4_RS03520	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
K08M4_RS03525	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
K08M4_RS03530	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K08M4_RS03535	COG0142	geranyltranstransferase activity
K08M4_RS03540	COG1722	exodeoxyribonuclease VII activity
K08M4_RS03545	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K08M4_RS03555	COG0301	tRNA thio-modification
K08M4_RS03555	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K08M4_RS03560	COG0583	DNA-binding transcription factor activity
K08M4_RS03575	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
K08M4_RS03585	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K08M4_RS03590	COG0321	lipoyl(octanoyl) transferase activity
K08M4_RS03600	COG1686	Belongs to the peptidase S11 family
K08M4_RS03605	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
K08M4_RS03610	COG0772	Belongs to the SEDS family
K08M4_RS03615	COG0768	penicillin binding
K08M4_RS03620	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K08M4_RS03625	COG0799	negative regulation of ribosome biogenesis
K08M4_RS03630	COG1466	dna polymerase III delta subunit
K08M4_RS03635	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
K08M4_RS03640	COG0495	leucyl-tRNA aminoacylation
K08M4_RS03645	COG2888	peptidyl-tyrosine sulfation
K08M4_RS03650	COG0815	Transfers the fatty acyl group on membrane lipoproteins
K08M4_RS03655	COG4535	Mg2 and Co2 transporter CorC
K08M4_RS03660	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K08M4_RS03665	COG1702	phosphate starvation-inducible protein PhoH
K08M4_RS03675	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K08M4_RS03680	COG2706	6-phosphogluconolactonase activity
K08M4_RS03780	COG0012	GTP binding
K08M4_RS03785	COG0193	aminoacyl-tRNA hydrolase activity
K08M4_RS03790	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K08M4_RS03795	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K08M4_RS03800	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
K08M4_RS03805	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
K08M4_RS03810	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K08M4_RS03815	COG2890	protein-(glutamine-N5) methyltransferase activity
K08M4_RS03820	COG3094	Invasion gene expression up-regulator, SirB
K08M4_RS03825	COG2912	Transglutaminase-like superfamily
K08M4_RS03830	COG2877	3-deoxy-8-phosphooctulonate synthase activity
K08M4_RS03840	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K08M4_RS03845	COG1187	pseudouridine synthase activity
K08M4_RS03850	COG2840	Smr protein MutS2
K08M4_RS03885	COG2217	Heavy metal translocating P-type atpase
K08M4_RS03885	COG2608	mercury ion transmembrane transporter activity
K08M4_RS03900	COG1028	Short-chain dehydrogenase reductase Sdr
K08M4_RS03940	COG1216	Glycosyl transferase, family 2
K08M4_RS03960	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K08M4_RS03965	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K08M4_RS04025	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
K08M4_RS04030	COG0835	chemotaxis
K08M4_RS04030	COG0784	Response regulator, receiver
K08M4_RS04035	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
K08M4_RS04040	COG1815	bacterial-type flagellum-dependent cell motility
K08M4_RS04045	COG1558	bacterial-type flagellum-dependent cell motility
K08M4_RS04055	COG1749	Flagellar hook protein flgE
K08M4_RS04060	COG4787	bacterial-type flagellum-dependent cell motility
K08M4_RS04070	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
K08M4_RS04075	COG1706	bacterial-type flagellum-dependent cell motility
K08M4_RS04080	COG1705	Flagellar rod assembly protein muramidase FlgJ
K08M4_RS04080	COG3951	Flagellar rod assembly protein muramidase FlgJ
K08M4_RS04105	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K08M4_RS04110	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K08M4_RS04120	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
K08M4_RS04130	COG1516	flagellar protein fliS
K08M4_RS04150	COG1677	Flagellar hook-basal body complex protein FliE
K08M4_RS04160	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K08M4_RS04210	COG1987	bacterial-type flagellum assembly
K08M4_RS04215	COG1684	flagellar biosynthetic protein fliR
K08M4_RS04250	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
K08M4_RS04255	COG2198	Histidine kinase
K08M4_RS04255	COG0784	Response regulator, receiver
K08M4_RS04255	COG0643	Histidine kinase
K08M4_RS04260	COG2201	protein-glutamate methylesterase activity
K08M4_RS04265	COG1192	Involved in chromosome partitioning
K08M4_RS04275	COG0835	chemotaxis
K08M4_RS04285	COG4133	protoheme IX ABC transporter activity
K08M4_RS04290	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K08M4_RS04295	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K08M4_RS04300	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K08M4_RS04305	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
K08M4_RS04310	COG1138	Cytochrome C-type biogenesis protein
K08M4_RS04315	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K08M4_RS04320	COG3088	subunit of a heme lyase
K08M4_RS04320	COG4235	cytochrome complex assembly
K08M4_RS04325	COG3088	subunit of a heme lyase
K08M4_RS04325	COG4235	cytochrome complex assembly
K08M4_RS04335	COG2067	long-chain fatty acid transport protein
K08M4_RS04340	COG2067	long-chain fatty acid transport protein
K08M4_RS04355	COG0183	Belongs to the thiolase family
K08M4_RS04360	COG1250	3-hydroxyacyl-CoA dehydrogenase
K08M4_RS04360	COG1024	Enoyl-CoA hydratase
K08M4_RS04370	COG2062	phosphohistidine phosphatase, SixA
K08M4_RS04375	COG2840	Smr protein MutS2
K08M4_RS04380	COG2890	protein-(glutamine-N5) methyltransferase activity
K08M4_RS04385	COG1280	lysine exporter protein (LysE YggA)
K08M4_RS04390	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
K08M4_RS04410	COG1175	transmembrane transport
K08M4_RS04420	COG3842	ATPase activity
K08M4_RS04425	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K08M4_RS04430	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
K08M4_RS04435	COG2894	cell division
K08M4_RS04440	COG0850	regulation of cytokinetic process
K08M4_RS04445	COG3100	YcgL domain-containing protein
K08M4_RS04450	COG2951	lytic endotransglycosylase activity
K08M4_RS04455	COG0583	DNA-binding transcription factor activity
K08M4_RS04460	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K08M4_RS04470	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K08M4_RS04480	COG2153	protein acetylation
K08M4_RS04485	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K08M4_RS04500	COG2860	membrane
K08M4_RS04505	COG3101	peptidyl-lysine hydroxylation
K08M4_RS04515	COG0431	NADPH-dependent FMN reductase
K08M4_RS04525	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K08M4_RS04535	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K08M4_RS04540	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K08M4_RS04550	COG0101	tRNA pseudouridine synthase activity
K08M4_RS04560	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K08M4_RS04565	COG0285	dihydrofolate synthase activity
K08M4_RS04570	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
K08M4_RS04575	COG1286	toxin biosynthetic process
K08M4_RS04580	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
K08M4_RS04585	COG0583	DNA-binding transcription factor activity
K08M4_RS04590	COG0745	RESPONSE REGULATOR receiver
K08M4_RS04600	COG2832	Protein of unknown function (DUF454)
K08M4_RS04605	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K08M4_RS04610	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
K08M4_RS04615	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
K08M4_RS04620	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K08M4_RS04635	COG2983	Belongs to the UPF0260 family
K08M4_RS04640	COG1785	Belongs to the alkaline phosphatase family
K08M4_RS04660	COG2226	methyltransferase
K08M4_RS04675	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K08M4_RS04680	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K08M4_RS04690	COG3139	Protein of unknown function (DUF1315)
K08M4_RS04695	COG0252	asparaginase activity
K08M4_RS04700	COG0616	signal peptide processing
K08M4_RS04705	COG1902	pentaerythritol trinitrate reductase activity
K08M4_RS04705	COG0446	pyridine nucleotide-disulphide oxidoreductase
K08M4_RS04710	COG0778	Nitroreductase
K08M4_RS04715	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K08M4_RS04730	COG0123	including yeast histone deacetylase and acetoin utilization protein
K08M4_RS04740	COG1959	2 iron, 2 sulfur cluster binding
K08M4_RS04755	COG3083	sulfuric ester hydrolase activity
K08M4_RS04760	COG3082	Protein of unknown function (DUF1414)
K08M4_RS04765	COG3081	Nucleoid-associated protein
K08M4_RS04780	COG1757	Na H antiporter
K08M4_RS04785	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K08M4_RS04790	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K08M4_RS04795	COG2095	MarC family integral membrane protein
K08M4_RS04800	COG1454	alcohol dehydrogenase
K08M4_RS04800	COG1012	belongs to the aldehyde dehydrogenase family
K08M4_RS04820	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
K08M4_RS04830	COG2056	Na+-H+ antiporter family
K08M4_RS04850	COG0346	lactoylglutathione lyase activity
K08M4_RS04855	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K08M4_RS04860	COG4660	Part of a membrane complex involved in electron transport
K08M4_RS04865	COG4659	FMN binding
K08M4_RS04870	COG4658	electron transport chain
K08M4_RS04875	COG4656	Part of a membrane complex involved in electron transport
K08M4_RS04880	COG2878	Part of a membrane complex involved in electron transport
K08M4_RS04885	COG4657	Part of a membrane complex involved in electron transport
K08M4_RS04895	COG0556	nucleotide-excision repair
K08M4_RS04900	COG2204	response regulator
K08M4_RS04905	COG2198	Histidine kinase
K08M4_RS04910	COG0391	Required for morphogenesis under gluconeogenic growth conditions
K08M4_RS04915	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K08M4_RS04925	COG0521	Mo-molybdopterin cofactor biosynthetic process
K08M4_RS04930	COG0315	cyclic pyranopterin monophosphate synthase activity
K08M4_RS04935	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
K08M4_RS04940	COG0314	molybdopterin synthase activity
K08M4_RS04945	COG3385	transposase activity
K08M4_RS04955	COG0601	transmembrane transport
K08M4_RS04960	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K08M4_RS04965	COG0444	Belongs to the ABC transporter superfamily
K08M4_RS04975	COG0435	Glutathione S-transferase
K08M4_RS04985	COG0280	phosphate acetyltransferase
K08M4_RS04985	COG0857	belongs to the CobB CobQ family
K08M4_RS04990	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K08M4_RS04995	COG3092	negative regulation of chromosome organization
K08M4_RS05005	COG3706	GGDEF domain
K08M4_RS05010	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K08M4_RS05020	COG0653	protein targeting
K08M4_RS05025	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
K08M4_RS05030	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K08M4_RS05035	COG2186	Transcriptional regulator
K08M4_RS05045	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K08M4_RS05045	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K08M4_RS05050	COG0489	protein tyrosine kinase activity
K08M4_RS05055	COG0572	uridine kinase
K08M4_RS05060	COG2982	Protein involved in outer membrane biogenesis
K08M4_RS05065	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
K08M4_RS05070	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K08M4_RS05075	COG0659	secondary active sulfate transmembrane transporter activity
K08M4_RS05080	COG1530	ribonuclease E activity
K08M4_RS05085	COG0564	pseudouridine synthase activity
K08M4_RS05095	COG1399	metal-binding, possibly nucleic acid-binding protein
K08M4_RS05100	COG0333	Belongs to the bacterial ribosomal protein bL32 family
K08M4_RS05105	COG0416	fatty acid biosynthetic process
K08M4_RS05110	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K08M4_RS05140	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K08M4_RS05145	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K08M4_RS05150	COG0470	DNA polymerase III
K08M4_RS05155	COG0084	hydrolase, TatD family'
K08M4_RS05175	COG0733	neurotransmitter:sodium symporter activity
K08M4_RS05185	COG4667	esterase of the alpha-beta hydrolase superfamily
K08M4_RS05190	COG0469	pyruvate kinase activity
K08M4_RS05195	COG1940	carbohydrate kinase activity
K08M4_RS05200	COG0835	chemotaxis
K08M4_RS05200	COG0784	Response regulator, receiver
K08M4_RS05215	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K08M4_RS05220	COG1028	Short-chain dehydrogenase reductase Sdr
K08M4_RS05225	COG0616	signal peptide processing
K08M4_RS05230	COG2719	SpoVR family
K08M4_RS05235	COG2718	Belongs to the UPF0229 family
K08M4_RS05240	COG2766	serine protein kinase
K08M4_RS05245	COG3013	Belongs to the UPF0304 family
K08M4_RS05250	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K08M4_RS05260	COG1882	Formate acetyltransferase
K08M4_RS05285	COG4160	amino acid transport
K08M4_RS05295	COG0708	Exodeoxyribonuclease III
K08M4_RS05300	COG1770	oligopeptidase
K08M4_RS05305	COG2814	Major facilitator Superfamily
K08M4_RS05310	COG0840	transmembrane signaling receptor activity
K08M4_RS05315	COG2850	peptidyl-arginine hydroxylation
K08M4_RS05335	COG1199	ATP-dependent helicase activity
K08M4_RS05340	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K08M4_RS05350	COG1187	pseudouridine synthase activity
K08M4_RS05360	COG1278	Cold shock
K08M4_RS05365	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
K08M4_RS05370	COG0542	response to heat
K08M4_RS05375	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K08M4_RS05380	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
K08M4_RS05385	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
K08M4_RS05395	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
K08M4_RS05405	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K08M4_RS05410	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K08M4_RS05415	COG0297	glycogen (starch) synthase activity
K08M4_RS05435	COG3070	regulator of competence-specific genes
K08M4_RS05440	COG1609	Transcriptional regulator
K08M4_RS05445	COG3381	protein complex oligomerization
K08M4_RS05450	COG0745	RESPONSE REGULATOR receiver
K08M4_RS05455	COG1434	Gram-negative-bacterium-type cell wall biogenesis
K08M4_RS05460	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K08M4_RS05465	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
K08M4_RS05470	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
K08M4_RS05475	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K08M4_RS05480	COG0840	transmembrane signaling receptor activity
K08M4_RS05495	COG4067	protein conserved in archaea
K08M4_RS05495	COG0189	ligase activity
K08M4_RS05500	COG0500	methyltransferase
K08M4_RS05505	COG4106	trans-aconitate 2-methyltransferase activity
K08M4_RS05510	COG1801	Protein of unknown function DUF72
K08M4_RS05515	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K08M4_RS05520	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
K08M4_RS05525	COG0632	four-way junction helicase activity
K08M4_RS05530	COG2255	four-way junction helicase activity
K08M4_RS05535	COG1271	oxidase subunit
K08M4_RS05540	COG1294	oxidase, subunit
K08M4_RS05545	COG4890	Cyd operon protein YbgT
K08M4_RS05555	COG0824	Thioesterase
K08M4_RS05560	COG0811	peptide transport
K08M4_RS05575	COG0823	Involved in the tonB-independent uptake of proteins
K08M4_RS05580	COG2885	chlorophyll binding
K08M4_RS05585	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
K08M4_RS05590	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
K08M4_RS05595	COG4774	siderophore transport
K08M4_RS05595	COG1629	transport
K08M4_RS05600	COG2375	cellular response to nickel ion
K08M4_RS05605	COG4592	Periplasmic binding protein
K08M4_RS05610	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K08M4_RS05615	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K08M4_RS05620	COG1120	ATPase activity
K08M4_RS05635	COG0784	Response regulator, receiver
K08M4_RS05635	COG5002	protein histidine kinase activity
K08M4_RS05650	COG0583	DNA-binding transcription factor activity
K08M4_RS05655	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K08M4_RS05675	COG0745	RESPONSE REGULATOR receiver
K08M4_RS05680	COG0463	Glycosyl transferase, family 2
K08M4_RS05685	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
K08M4_RS05695	COG1032	radical SAM domain protein
K08M4_RS05715	COG0583	DNA-binding transcription factor activity
K08M4_RS05720	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
K08M4_RS05730	COG2350	Protein conserved in bacteria
K08M4_RS05735	COG1607	acyl-coa hydrolase
K08M4_RS05740	COG2917	probably involved in intracellular septation
K08M4_RS05775	COG2203	Gaf domain
K08M4_RS05775	COG3706	GGDEF domain
K08M4_RS05775	COG4251	negative regulation of phosphorylation
K08M4_RS05775	COG5001	Diguanylate cyclase
K08M4_RS05780	COG0840	transmembrane signaling receptor activity
K08M4_RS05800	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K08M4_RS05805	COG4136	ATPase activity
K08M4_RS05810	COG4135	transport system, permease component
K08M4_RS05815	COG4134	Bacterial extracellular solute-binding protein
K08M4_RS05825	COG3313	Fe-S protein
K08M4_RS05840	COG0513	Belongs to the DEAD box helicase family
K08M4_RS05845	COG1280	lysine exporter protein (LysE YggA)
K08M4_RS05855	COG2866	Carboxypeptidase
K08M4_RS05880	COG4176	ABC-type proline glycine betaine transport system permease component
K08M4_RS05885	COG2113	Glycine betaine
K08M4_RS05895	COG0583	DNA-binding transcription factor activity
K08M4_RS05905	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
K08M4_RS05910	COG4988	ABC transporter
K08M4_RS05915	COG0492	ferredoxin-NADP+ reductase activity
K08M4_RS05930	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K08M4_RS05945	COG2199	diguanylate cyclase activity
K08M4_RS05945	COG2203	Gaf domain
K08M4_RS05960	COG0471	metal ion transport
K08M4_RS05965	COG2949	membrane
K08M4_RS05970	COG0281	malic enzyme
K08M4_RS05975	COG1643	Atp-dependent helicase
K08M4_RS05985	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K08M4_RS06020	COG0277	FAD linked oxidase domain protein
K08M4_RS06020	COG0247	lactate metabolic process
K08M4_RS06040	COG2986	histidine ammonia-lyase
K08M4_RS06045	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
K08M4_RS06050	COG0010	Belongs to the arginase family
K08M4_RS06055	COG1228	amidohydrolase
K08M4_RS06065	COG4326	sporulation control protein
K08M4_RS06115	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K08M4_RS06120	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
K08M4_RS06125	COG3097	Belongs to the UPF0267 family
K08M4_RS06140	COG0488	(ABC) transporter
K08M4_RS06150	COG1309	transcriptional regulator
K08M4_RS06160	COG1166	arginine decarboxylase activity
K08M4_RS06165	COG0010	Belongs to the arginase family
K08M4_RS06175	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K08M4_RS06180	COG0800	Aldolase
K08M4_RS06185	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K08M4_RS06190	COG1917	Cupin 2, conserved barrel domain protein
K08M4_RS06220	COG2186	Transcriptional regulator
K08M4_RS06225	COG2186	Transcriptional regulator
K08M4_RS06230	COG0517	IMP dehydrogenase activity
K08M4_RS06245	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K08M4_RS06305	COG0471	metal ion transport
K08M4_RS06310	COG4191	Histidine kinase
K08M4_RS06310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K08M4_RS06350	COG0730	response to heat
K08M4_RS06360	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
K08M4_RS06365	COG1280	lysine exporter protein (LysE YggA)
K08M4_RS06370	COG1115	amino acid carrier protein
K08M4_RS06385	COG1115	amino acid carrier protein
K08M4_RS06390	COG0776	regulation of translation
K08M4_RS06410	COG2378	regulation of single-species biofilm formation
K08M4_RS06425	COG0583	DNA-binding transcription factor activity
K08M4_RS06435	COG2175	clavaminate synthase activity
K08M4_RS06450	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K08M4_RS06460	COG0523	cobalamin synthesis protein
K08M4_RS06470	COG0776	regulation of translation
K08M4_RS06480	COG0500	methyltransferase
K08M4_RS06485	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
K08M4_RS06490	COG0295	cytidine deaminase activity
K08M4_RS06495	COG1346	cytolysis
K08M4_RS06505	COG2925	Exonuclease
K08M4_RS06525	COG3122	Protein conserved in bacteria
K08M4_RS06535	COG1823	symporter activity
K08M4_RS06540	COG0702	epimerase
K08M4_RS06545	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
K08M4_RS06550	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
K08M4_RS06555	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
K08M4_RS06575	COG2988	succinylglutamate desuccinylase activity
K08M4_RS06580	COG4139	cobalamin transport
K08M4_RS06585	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
K08M4_RS06630	COG1247	-acetyltransferase
K08M4_RS06650	COG2814	Major facilitator Superfamily
K08M4_RS06655	COG0583	DNA-binding transcription factor activity
K08M4_RS06665	COG1451	nucleotide metabolic process
K08M4_RS06675	COG3063	Type IV pilus biogenesis stability protein PilW
K08M4_RS06680	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
K08M4_RS06695	COG2195	Cleaves the N-terminal amino acid of tripeptides
K08M4_RS06720	COG0582	viral genome integration into host DNA
K08M4_RS06760	COG2003	Belongs to the UPF0758 family
K08M4_RS06765	COG0328	RNA-DNA hybrid ribonuclease activity
K08M4_RS06820	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
K08M4_RS06825	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
K08M4_RS06855	COG1401	restriction endodeoxyribonuclease activity
K08M4_RS06870	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K08M4_RS06875	COG0583	DNA-binding transcription factor activity
K08M4_RS06890	COG0840	transmembrane signaling receptor activity
K08M4_RS06905	COG4771	TonB-dependent receptor
K08M4_RS06915	COG0454	-acetyltransferase
K08M4_RS06930	COG0420	3'-5' exonuclease activity
K08M4_RS06935	COG0419	ATPase involved in DNA repair
K08M4_RS06955	COG3046	protein related to deoxyribodipyrimidine photolyase
K08M4_RS06965	COG0589	response to stress
K08M4_RS06985	COG2271	Major facilitator Superfamily
K08M4_RS07000	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K08M4_RS07020	COG0494	nUDIX hydrolase
K08M4_RS07035	COG1187	pseudouridine synthase activity
K08M4_RS07070	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K08M4_RS07090	COG1051	belongs to the nudix hydrolase family
K08M4_RS07110	COG0346	lactoylglutathione lyase activity
K08M4_RS07130	COG0653	protein targeting
K08M4_RS07140	COG1028	Short-chain dehydrogenase reductase Sdr
K08M4_RS07170	COG0826	peptidase U32
K08M4_RS07185	COG1126	abc transporter atp-binding protein
K08M4_RS07190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K08M4_RS07195	COG4215	(ABC) transporter
K08M4_RS07200	COG4160	amino acid transport
K08M4_RS07210	COG0517	IMP dehydrogenase activity
K08M4_RS07245	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K08M4_RS07280	COG1742	UPF0060 membrane protein
K08M4_RS07315	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K08M4_RS07320	COG1215	transferase activity, transferring glycosyl groups
K08M4_RS07325	COG0438	transferase activity, transferring glycosyl groups
K08M4_RS07350	COG0438	transferase activity, transferring glycosyl groups
K08M4_RS07355	COG2204	response regulator
K08M4_RS07365	COG3448	diguanylate cyclase activity
K08M4_RS07365	COG4175	Glycine betaine
K08M4_RS07370	COG4176	ABC-type proline glycine betaine transport system permease component
K08M4_RS07390	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
K08M4_RS07390	COG2885	chlorophyll binding
K08M4_RS07400	COG1793	dna ligase
K08M4_RS07405	COG0534	Mate efflux family protein
K08M4_RS07410	COG0307	riboflavin synthase, alpha
K08M4_RS07430	COG0791	NLP P60 protein
K08M4_RS07435	COG0840	transmembrane signaling receptor activity
K08M4_RS07445	COG3148	PFAM DTW domain containing protein
K08M4_RS07450	COG1940	carbohydrate kinase activity
K08M4_RS07460	COG0303	'Molybdopterin
K08M4_RS07465	COG0746	molybdenum cofactor guanylyltransferase activity
K08M4_RS07470	COG3842	ATPase activity
K08M4_RS07475	COG4662	Binding-protein-dependent transport system inner membrane component
K08M4_RS07490	COG4191	Histidine kinase
K08M4_RS07505	COG0488	(ABC) transporter
K08M4_RS07510	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K08M4_RS07530	COG3381	protein complex oligomerization
K08M4_RS07540	COG3383	formate dehydrogenase (NAD+) activity
K08M4_RS07540	COG0243	molybdopterin cofactor binding
K08M4_RS07545	COG0437	4 iron, 4 sulfur cluster binding
K08M4_RS07560	COG0004	ammonium transporteR
K08M4_RS07565	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K08M4_RS07570	COG3706	GGDEF domain
K08M4_RS07575	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K08M4_RS07585	COG1177	transmembrane transport
K08M4_RS07595	COG3842	ATPase activity
K08M4_RS07615	COG0037	tRNA processing
K08M4_RS07620	COG0589	response to stress
K08M4_RS07625	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K08M4_RS07640	COG2217	Heavy metal translocating P-type atpase
K08M4_RS07650	COG2010	Cytochrome c
K08M4_RS07665	COG3278	Belongs to the heme-copper respiratory oxidase family
K08M4_RS07680	COG5002	protein histidine kinase activity
K08M4_RS07680	COG0784	Response regulator, receiver
K08M4_RS07685	COG2801	Transposase and inactivated derivatives
K08M4_RS07735	COG3335	DDE superfamily endonuclease
K08M4_RS07760	COG3120	sequence-specific DNA binding
K08M4_RS07765	COG1067	ATP-dependent peptidase activity
K08M4_RS07785	COG0488	(ABC) transporter
K08M4_RS07795	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K08M4_RS07795	COG0116	Belongs to the methyltransferase superfamily
K08M4_RS07805	COG0167	dihydroorotate dehydrogenase activity
K08M4_RS07810	COG2902	Dehydrogenase
K08M4_RS07820	COG0308	aminopeptidase N
K08M4_RS07835	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
K08M4_RS07840	COG1956	GAF domain-containing protein
K08M4_RS07845	COG1132	(ABC) transporter
K08M4_RS07850	COG2995	paraquat-inducible protein a
K08M4_RS07855	COG3008	intermembrane lipid transfer
K08M4_RS07860	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
K08M4_RS07860	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K08M4_RS07865	COG2996	Protein conserved in bacteria
K08M4_RS07880	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K08M4_RS07880	COG0574	Belongs to the PEP-utilizing enzyme family
K08M4_RS07885	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K08M4_RS07890	COG1666	GTP binding
K08M4_RS07900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K08M4_RS07905	COG4597	amino acid ABC transporter
K08M4_RS07910	COG0765	amino acid transport
K08M4_RS07915	COG1126	abc transporter atp-binding protein
K08M4_RS07920	COG0670	Belongs to the BI1 family
K08M4_RS07925	COG2920	part of a sulfur-relay system
K08M4_RS07935	COG0840	transmembrane signaling receptor activity
K08M4_RS07965	COG3706	GGDEF domain
K08M4_RS07970	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
K08M4_RS07975	COG0602	queuosine metabolic process
K08M4_RS07980	COG0561	phosphatase activity
K08M4_RS08010	COG2828	Protein conserved in bacteria
K08M4_RS08015	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
K08M4_RS08020	COG0372	Belongs to the citrate synthase family
K08M4_RS08025	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
K08M4_RS08035	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
K08M4_RS08070	COG4628	conserved protein (DUF2132)
K08M4_RS08075	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
K08M4_RS08080	COG0363	glucosamine-6-phosphate deaminase activity
K08M4_RS08085	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K08M4_RS08090	COG4565	transcriptional regulatory protein
K08M4_RS08095	COG3290	protein histidine kinase activity
K08M4_RS08110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K08M4_RS08140	COG1342	Belongs to the UPF0251 family
K08M4_RS08210	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K08M4_RS08215	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
K08M4_RS08275	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K08M4_RS08275	COG0072	phenylalanine-tRNA ligase activity
K08M4_RS08280	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K08M4_RS08330	COG1643	Atp-dependent helicase
K08M4_RS08345	COG0395	ABC-type sugar transport system, permease component
K08M4_RS08355	COG1653	transport
K08M4_RS08360	COG1609	Transcriptional regulator
K08M4_RS08365	COG3459	Glycosyltransferase 36 associated
K08M4_RS08370	COG3842	ATPase activity
K08M4_RS08410	COG3706	GGDEF domain
K08M4_RS08425	COG0443	Heat shock 70 kDa protein
K08M4_RS08440	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K08M4_RS08455	COG3106	COG3106 Predicted ATPase
K08M4_RS08480	COG0784	Response regulator, receiver
K08M4_RS08480	COG5002	protein histidine kinase activity
K08M4_RS08490	COG0494	nUDIX hydrolase
K08M4_RS08495	COG0814	amino acid
K08M4_RS08500	COG1760	l-serine dehydratase
K08M4_RS08505	COG0814	amino acid
K08M4_RS08510	COG0720	synthase
K08M4_RS08515	COG0840	transmembrane signaling receptor activity
K08M4_RS08520	COG0659	secondary active sulfate transmembrane transporter activity
K08M4_RS08525	COG0017	Asparaginyl-tRNA synthetase
K08M4_RS08540	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K08M4_RS08550	COG2770	Histidine kinase
K08M4_RS08550	COG3437	response regulator, receiver
K08M4_RS08570	COG1448	Aminotransferase
K08M4_RS08590	COG2258	MOSC domain
K08M4_RS08595	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
K08M4_RS08605	COG3852	Histidine kinase
K08M4_RS08610	COG2204	response regulator
K08M4_RS08620	COG3070	regulator of competence-specific genes
K08M4_RS08635	COG2431	L-lysine efflux transmembrane transporter activity
K08M4_RS08645	COG0076	glutamate decarboxylase activity
K08M4_RS08650	COG1737	Transcriptional regulator
K08M4_RS08660	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K08M4_RS08665	COG2985	domain, Protein
K08M4_RS08665	COG3273	potassium ion transport
K08M4_RS08670	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K08M4_RS08700	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K08M4_RS08720	COG0534	Mate efflux family protein
K08M4_RS08725	COG0702	epimerase
K08M4_RS08735	COG2814	Major facilitator Superfamily
K08M4_RS08745	COG1061	Type III restriction enzyme res subunit
K08M4_RS08750	COG3300	MHYT domain
K08M4_RS08750	COG5001	Diguanylate cyclase
K08M4_RS08765	COG0642	Histidine kinase
K08M4_RS08775	COG0586	Pfam SNARE associated Golgi protein
K08M4_RS08785	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
K08M4_RS08830	COG2026	Addiction module toxin, RelE StbE family
K08M4_RS08855	COG0517	IMP dehydrogenase activity
K08M4_RS08865	COG0517	IMP dehydrogenase activity
K08M4_RS08880	COG2124	cytochrome p450
K08M4_RS08910	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K08M4_RS08915	COG1780	Probably involved in ribonucleotide reductase function
K08M4_RS08925	COG0316	Belongs to the HesB IscA family
K08M4_RS08930	COG0719	Fe-S assembly protein
K08M4_RS08935	COG0719	Fe-S assembly protein
K08M4_RS08945	COG2166	iron-sulfur cluster assembly
K08M4_RS08955	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K08M4_RS08960	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K08M4_RS08990	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
K08M4_RS09005	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K08M4_RS09010	COG3108	Peptidase M15
K08M4_RS09015	COG2989	Protein conserved in bacteria
K08M4_RS09040	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K08M4_RS09045	COG3088	subunit of a heme lyase
K08M4_RS09045	COG4235	cytochrome complex assembly
K08M4_RS09055	COG1138	Cytochrome C-type biogenesis protein
K08M4_RS09060	COG3301	Polysulphide reductase, NrfD
K08M4_RS09065	COG0437	4 iron, 4 sulfur cluster binding
K08M4_RS09070	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
K08M4_RS09075	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
K08M4_RS09080	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K08M4_RS09095	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K08M4_RS09100	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K08M4_RS09105	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K08M4_RS09140	COG0019	diaminopimelate decarboxylase activity
K08M4_RS09180	COG0322	excinuclease ABC activity
K08M4_RS09185	COG2197	response regulator
K08M4_RS09190	COG0417	DNA replication proofreading
K08M4_RS09200	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K08M4_RS09215	COG1187	pseudouridine synthase activity
K08M4_RS09220	COG0009	L-threonylcarbamoyladenylate synthase
K08M4_RS09225	COG0613	PHP domain protein
K08M4_RS09235	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K08M4_RS09240	COG0512	Glutamine amidotransferase of anthranilate synthase
K08M4_RS09245	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K08M4_RS09250	COG0134	indole-3-glycerol-phosphate synthase activity
K08M4_RS09250	COG0135	phosphoribosylanthranilate isomerase activity
K08M4_RS09255	COG0133	tryptophan synthase activity
K08M4_RS09260	COG0159	tryptophan synthase activity
K08M4_RS09265	COG1301	dicarboxylic acid transport
K08M4_RS09270	COG3385	transposase activity
K08M4_RS09280	COG0564	pseudouridine synthase activity
K08M4_RS09290	COG0733	neurotransmitter:sodium symporter activity
K08M4_RS09300	COG0626	cystathionine gamma-synthase activity
K08M4_RS09305	COG2818	Glycosylase
K08M4_RS09320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K08M4_RS09325	COG1983	PspC domain protein
K08M4_RS09335	COG1842	Phage shock protein A
K08M4_RS09340	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
K08M4_RS09345	COG4166	transmembrane transport
K08M4_RS09350	COG4168	peptide transport system, permease
K08M4_RS09365	COG4172	Belongs to the ABC transporter superfamily
K08M4_RS09380	COG1227	inorganic diphosphatase activity
K08M4_RS09390	COG0243	molybdopterin cofactor binding
K08M4_RS09395	COG3005	denitrification pathway
K08M4_RS09400	COG4459	periplasmic nitrate reductase
K08M4_RS09405	COG0390	transport system, permease component
K08M4_RS09410	COG2116	formate transmembrane transporter activity
K08M4_RS09440	COG0215	cysteine-tRNA ligase activity
K08M4_RS09445	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K08M4_RS09450	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K08M4_RS09455	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
K08M4_RS09460	COG3012	SEC-C Motif Domain Protein
K08M4_RS09465	COG0140	phosphoribosyl-ATP diphosphatase activity
K08M4_RS09465	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K08M4_RS09470	COG0107	imidazoleglycerol-phosphate synthase activity
K08M4_RS09475	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K08M4_RS09480	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
K08M4_RS09485	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
K08M4_RS09485	COG0131	Imidazoleglycerol-phosphate dehydratase
K08M4_RS09490	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K08M4_RS09505	COG1757	Na H antiporter
K08M4_RS09510	COG2916	Histone family protein nucleoid-structuring protein H-NS
K08M4_RS09515	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K08M4_RS09530	COG2915	High frequency lysogenization protein hflD homolog
K08M4_RS09535	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K08M4_RS09540	COG0501	Belongs to the peptidase M48B family
K08M4_RS09560	COG0156	8-amino-7-oxononanoate synthase activity
K08M4_RS09570	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K08M4_RS09630	COG1757	Na H antiporter
K08M4_RS09635	COG2916	Histone family protein nucleoid-structuring protein H-NS
K08M4_RS09640	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K08M4_RS09655	COG2915	High frequency lysogenization protein hflD homolog
K08M4_RS09660	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K08M4_RS09665	COG0501	Belongs to the peptidase M48B family
K08M4_RS09685	COG0156	8-amino-7-oxononanoate synthase activity
K08M4_RS09690	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
K08M4_RS09695	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K08M4_RS09710	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K08M4_RS09715	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K08M4_RS09720	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
K08M4_RS09725	COG1674	ftsk spoiiie
K08M4_RS09730	COG1522	sequence-specific DNA binding
K08M4_RS09735	COG0686	Belongs to the AlaDH PNT family
K08M4_RS09745	COG0583	DNA-binding transcription factor activity
K08M4_RS09760	COG0284	orotidine-5'-phosphate decarboxylase activity
K08M4_RS09765	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
K08M4_RS09770	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
K08M4_RS09775	COG0776	regulation of translation
K08M4_RS09780	COG0539	negative regulation of cytoplasmic translation
K08M4_RS09785	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K08M4_RS09790	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
K08M4_RS09795	COG2835	tetraacyldisaccharide 4'-kinase activity
K08M4_RS09800	COG1663	tetraacyldisaccharide 4'-kinase activity
K08M4_RS09805	COG1132	(ABC) transporter
K08M4_RS09810	COG0658	competence protein
K08M4_RS09810	COG2333	competence protein COMEC
K08M4_RS09820	COG4591	ABC-type transport system involved in lipoprotein release permease component
K08M4_RS09825	COG1136	(ABC) transporter
K08M4_RS09830	COG4591	ABC-type transport system involved in lipoprotein release permease component
K08M4_RS09840	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K08M4_RS09855	COG1252	NADH dehydrogenase
K08M4_RS09860	COG3150	esterase
K08M4_RS09885	COG0537	adenosine 5'-monophosphoramidase activity
K08M4_RS09915	COG0517	IMP dehydrogenase activity
K08M4_RS09915	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
K08M4_RS09915	COG0617	tRNA 3'-terminal CCA addition
K08M4_RS09930	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K08M4_RS09940	COG1902	pentaerythritol trinitrate reductase activity
K08M4_RS09945	COG0346	lactoylglutathione lyase activity
K08M4_RS09950	COG0583	DNA-binding transcription factor activity
K08M4_RS09965	COG2015	COG2015, Alkyl sulfatase and related hydrolases
K08M4_RS09985	COG1309	transcriptional regulator
K08M4_RS09990	COG0583	DNA-binding transcription factor activity
K08M4_RS10005	COG3040	lipid binding
K08M4_RS10010	COG1228	amidohydrolase
K08M4_RS10020	COG1120	ATPase activity
K08M4_RS10025	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K08M4_RS10090	COG1522	sequence-specific DNA binding
K08M4_RS10105	COG0583	DNA-binding transcription factor activity
K08M4_RS10110	COG1486	melibiose metabolic process
K08M4_RS10115	COG3394	polysaccharide catabolic process
K08M4_RS10120	COG0789	Transcriptional regulator
K08M4_RS10135	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K08M4_RS10160	COG1216	Glycosyl transferase, family 2
K08M4_RS10160	COG0463	Glycosyl transferase, family 2
K08M4_RS10165	COG0438	transferase activity, transferring glycosyl groups
K08M4_RS10170	COG0328	RNA-DNA hybrid ribonuclease activity
K08M4_RS10170	COG3341	Caulimovirus viroplasmin
K08M4_RS10210	COG3126	Type III secretion system lipoprotein chaperone (YscW)
K08M4_RS10215	COG1946	Acyl-CoA thioesterase
K08M4_RS10225	COG1522	sequence-specific DNA binding
K08M4_RS10230	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K08M4_RS10240	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K08M4_RS10300	COG2855	membrane
K08M4_RS10315	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
K08M4_RS10320	COG2267	carboxylic ester hydrolase activity
K08M4_RS10325	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
K08M4_RS10330	COG1169	isochorismate synthase
K08M4_RS10335	COG0436	Aminotransferase
K08M4_RS10345	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
K08M4_RS10350	COG0232	Belongs to the dGTPase family. Type 2 subfamily
K08M4_RS10365	COG1555	photosystem II stabilization
K08M4_RS10370	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K08M4_RS10375	COG0776	regulation of translation
K08M4_RS10380	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K08M4_RS10385	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K08M4_RS10390	COG0740	serine-type endopeptidase activity
K08M4_RS10395	COG0544	peptidyl-prolyl cis-trans isomerase activity
K08M4_RS10405	COG2204	response regulator
K08M4_RS10410	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K08M4_RS10415	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K08M4_RS10420	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K08M4_RS10440	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K08M4_RS10440	COG3321	synthase
K08M4_RS10455	COG2070	2-Nitropropane dioxygenase
K08M4_RS10455	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
K08M4_RS10460	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
K08M4_RS10465	COG0318	PFAM AMP-dependent synthetase and ligase
K08M4_RS10470	COG0596	Alpha beta hydrolase
K08M4_RS10485	COG1214	PFAM Peptidase M22, glycoprotease
K08M4_RS10490	COG1199	ATP-dependent helicase activity
K08M4_RS10500	COG0788	formyltetrahydrofolate deformylase activity
K08M4_RS10505	COG3102	Protein conserved in bacteria
K08M4_RS10510	COG0018	arginyl-trna synthetase
K08M4_RS10540	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
K08M4_RS10545	COG1121	(ABC) transporter
K08M4_RS10550	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K08M4_RS10560	COG0045	succinate-CoA ligase (ADP-forming) activity
K08M4_RS10565	COG0508	dehydrogenase complex catalyzes the overall conversion of
K08M4_RS10570	COG0567	Dehydrogenase, E1 component
K08M4_RS10580	COG1053	succinate dehydrogenase
K08M4_RS10585	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
K08M4_RS10595	COG0372	Belongs to the citrate synthase family
K08M4_RS10600	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
K08M4_RS10610	COG0033	Phosphoglucomutase
K08M4_RS10615	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
K08M4_RS10620	COG0596	Alpha beta hydrolase
K08M4_RS10645	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K08M4_RS10650	COG2190	(PTS) system
K08M4_RS10650	COG1263	PTS System
K08M4_RS10650	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K08M4_RS10655	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K08M4_RS10660	COG1940	carbohydrate kinase activity
K08M4_RS10660	COG1846	Transcriptional regulator
K08M4_RS10665	COG4651	solute:proton antiporter activity
K08M4_RS10665	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K08M4_RS10670	COG0367	asparagine synthase
K08M4_RS10675	COG0250	Participates in transcription elongation, termination and antitermination
K08M4_RS10680	COG3104	oligopeptide transport
K08M4_RS10685	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
K08M4_RS10690	COG0563	adenylate kinase activity
K08M4_RS10695	COG0326	Molecular chaperone. Has ATPase activity
K08M4_RS10700	COG3710	Transcriptional regulator
K08M4_RS10715	COG0622	Phosphoesterase
K08M4_RS10740	COG1090	epimerase
K08M4_RS10745	COG0300	oxidoreductase activity
K08M4_RS10750	COG3118	belongs to the thioredoxin family
K08M4_RS10755	COG0330	HflC and HflK could
K08M4_RS10850	COG0330	HflC and HflK could
K08M4_RS10860	COG0789	Transcriptional regulator
K08M4_RS10880	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K08M4_RS10895	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
K08M4_RS10905	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K08M4_RS10915	COG2190	(PTS) system
K08M4_RS10920	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K08M4_RS10925	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K08M4_RS10930	COG2837	iron assimilation
K08M4_RS10960	COG3264	Mechanosensitive ion channel
K08M4_RS10960	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K08M4_RS10970	COG0189	ligase activity
K08M4_RS10980	COG1393	Belongs to the ArsC family
K08M4_RS10985	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K08M4_RS11000	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
K08M4_RS11005	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K08M4_RS11010	COG2716	regulation of RNA biosynthetic process
K08M4_RS11015	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K08M4_RS11030	COG4783	chaperone-mediated protein folding
K08M4_RS11035	COG1393	Belongs to the ArsC family
K08M4_RS11055	COG2233	PERMEase
K08M4_RS11060	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K08M4_RS11065	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K08M4_RS11070	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K08M4_RS11075	COG0121	glutamine amidotransferase
K08M4_RS11080	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
K08M4_RS11085	COG1960	acyl-CoA dehydrogenase activity
K08M4_RS11095	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K08M4_RS11100	COG0328	RNA-DNA hybrid ribonuclease activity
K08M4_RS11105	COG2226	methyltransferase
K08M4_RS11110	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K08M4_RS11115	COG1388	LysM domain
K08M4_RS11115	COG0741	lytic transglycosylase activity
K08M4_RS11125	COG3021	interspecies interaction between organisms
K08M4_RS11130	COG0347	Belongs to the P(II) protein family
K08M4_RS11140	COG0037	tRNA processing
K08M4_RS11145	COG0825	malonyl-CoA metabolic process
K08M4_RS11150	COG0587	DNA-directed DNA polymerase activity
K08M4_RS11155	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
K08M4_RS11165	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K08M4_RS11170	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K08M4_RS11175	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K08M4_RS11180	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
K08M4_RS11190	COG0750	zinc metalloprotease
K08M4_RS11200	COG0575	Belongs to the CDS family
K08M4_RS11205	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K08M4_RS11215	COG0233	cytoplasmic translational termination
K08M4_RS11220	COG0528	UMP kinase activity
K08M4_RS11225	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K08M4_RS11230	COG0052	Belongs to the universal ribosomal protein uS2 family
K08M4_RS11235	COG0024	Methionine aminopeptidase
K08M4_RS11240	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
K08M4_RS11250	COG0564	pseudouridine synthase activity
K08M4_RS11255	COG3098	single-species biofilm formation
K08M4_RS11285	COG1671	Belongs to the UPF0178 family
K08M4_RS11290	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
K08M4_RS11300	COG0254	rRNA binding
K08M4_RS11305	COG1720	tRNA m6t6A37 methyltransferase activity
K08M4_RS11310	COG0442	prolyl-tRNA aminoacylation
K08M4_RS11340	COG3335	DDE superfamily endonuclease
K08M4_RS11345	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K08M4_RS11355	COG0366	Alpha amylase catalytic
K08M4_RS11360	COG1263	PTS System
K08M4_RS11360	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K08M4_RS11365	COG1609	Transcriptional regulator
K08M4_RS11375	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
K08M4_RS11380	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K08M4_RS11385	COG2011	ABC-type metal ion transport system permease component
K08M4_RS11390	COG1464	Belongs to the NlpA lipoprotein family
K08M4_RS11395	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
K08M4_RS11405	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K08M4_RS11405	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K08M4_RS11420	COG1611	Belongs to the LOG family
K08M4_RS11425	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K08M4_RS11430	COG0733	neurotransmitter:sodium symporter activity
K08M4_RS11445	COG0514	ATP-dependent DNA helicase (RecQ)
K08M4_RS11450	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K08M4_RS11460	COG2991	Protein conserved in bacteria
K08M4_RS11465	COG1477	protein flavinylation
K08M4_RS11470	COG2871	sodium ion transport
K08M4_RS11475	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K08M4_RS11480	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K08M4_RS11490	COG1805	sodium ion transport
K08M4_RS11495	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K08M4_RS11500	COG0271	Belongs to the BolA IbaG family
K08M4_RS11505	COG2813	Specifically methylates the guanine in position
K08M4_RS11515	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K08M4_RS11530	COG3248	Nucleoside-binding outer membrane protein
K08M4_RS11535	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K08M4_RS11540	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K08M4_RS11545	COG2166	iron-sulfur cluster assembly
K08M4_RS11550	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
K08M4_RS11555	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
K08M4_RS11565	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K08M4_RS11565	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
K08M4_RS11580	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K08M4_RS11585	COG1074	ATP-dependent DNA helicase activity
K08M4_RS11590	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
K08M4_RS11605	COG3141	response to X-ray
K08M4_RS11620	COG2095	MarC family integral membrane protein
K08M4_RS11625	COG2171	N-acyltransferase activity
K08M4_RS11630	COG0047	phosphoribosylformylglycinamidine synthase activity
K08M4_RS11630	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K08M4_RS11645	COG1253	flavin adenine dinucleotide binding
K08M4_RS11650	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
K08M4_RS11680	COG0484	heat shock protein binding
K08M4_RS11685	COG0443	Heat shock 70 kDa protein
K08M4_RS11690	COG3385	transposase activity
K08M4_RS11700	COG1301	dicarboxylic acid transport
K08M4_RS11705	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K08M4_RS11710	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K08M4_RS11715	COG0497	DNA recombination
K08M4_RS11720	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K08M4_RS11725	COG2914	Belongs to the UPF0125 (RnfH) family
K08M4_RS11730	COG2867	negative regulation of translational initiation
K08M4_RS11745	COG0189	ligase activity
K08M4_RS11745	COG4067	protein conserved in archaea
K08M4_RS11770	COG0204	Acyl-transferase
K08M4_RS11775	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
K08M4_RS11780	COG1115	amino acid carrier protein
K08M4_RS11785	COG1584	GPR1 FUN34 yaaH family protein
K08M4_RS11795	COG0519	Catalyzes the synthesis of GMP from XMP
K08M4_RS11795	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K08M4_RS11800	COG0516	GMP reductase activity
K08M4_RS11800	COG0517	IMP dehydrogenase activity
K08M4_RS11805	COG1570	exodeoxyribonuclease VII activity
K08M4_RS11815	COG3706	GGDEF domain
K08M4_RS11825	COG1160	GTP binding
K08M4_RS11830	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K08M4_RS11835	COG2976	Protein conserved in bacteria
K08M4_RS11840	COG0124	histidyl-tRNA synthetase
K08M4_RS11845	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K08M4_RS11855	COG0820	rRNA (adenine-C2-)-methyltransferase activity
K08M4_RS11860	COG0105	UTP biosynthetic process
K08M4_RS11865	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K08M4_RS11870	COG2975	iron-sulfur cluster assembly
K08M4_RS11880	COG0443	Heat shock 70 kDa protein
K08M4_RS11885	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
K08M4_RS11895	COG0822	iron-sulfur transferase activity
K08M4_RS11900	COG1104	cysteine desulfurase activity
K08M4_RS11905	COG1959	2 iron, 2 sulfur cluster binding
K08M4_RS11910	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
K08M4_RS11915	COG0483	inositol monophosphate 1-phosphatase activity
K08M4_RS11920	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K08M4_RS11925	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K08M4_RS11930	COG1862	Preprotein translocase
K08M4_RS11935	COG0343	queuine tRNA-ribosyltransferase activity
K08M4_RS11940	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K08M4_RS11945	COG0517	IMP dehydrogenase activity
K08M4_RS11950	COG1609	Transcriptional regulator
K08M4_RS11955	COG1621	beta-fructofuranosidase activity
K08M4_RS11960	COG1263	PTS System
K08M4_RS11960	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K08M4_RS11965	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K08M4_RS11970	COG0840	transmembrane signaling receptor activity
K08M4_RS11975	COG0583	DNA-binding transcription factor activity
K08M4_RS11980	COG0450	alkyl hydroperoxide reductase
K08M4_RS11985	COG3142	Participates in the control of copper homeostasis
K08M4_RS12000	COG0704	Plays a role in the regulation of phosphate uptake
K08M4_RS12005	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K08M4_RS12010	COG0581	inorganic phosphate transmembrane transporter activity
K08M4_RS12015	COG0573	inorganic phosphate transmembrane transporter activity
K08M4_RS12020	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K08M4_RS12025	COG0248	Ppx GppA phosphatase
K08M4_RS12035	COG5002	protein histidine kinase activity
K08M4_RS12040	COG0745	RESPONSE REGULATOR receiver
K08M4_RS12045	COG2974	May be involved in recombination
K08M4_RS12050	COG0826	peptidase U32
K08M4_RS12055	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K08M4_RS12065	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
K08M4_RS12070	COG3335	DDE superfamily endonuclease
K08M4_RS12120	COG0564	pseudouridine synthase activity
K08M4_RS12125	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K08M4_RS12130	COG0741	lytic transglycosylase activity
K08M4_RS12135	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K08M4_RS12140	COG1605	Chorismate mutase
K08M4_RS12140	COG0077	Prephenate dehydratase
K08M4_RS12145	COG5001	Diguanylate cyclase
K08M4_RS12150	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
K08M4_RS12155	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
K08M4_RS12165	COG0488	(ABC) transporter
K08M4_RS12175	COG0739	heme binding
K08M4_RS12180	COG1605	Chorismate mutase
K08M4_RS12180	COG0287	Prephenate dehydrogenase
K08M4_RS12185	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K08M4_RS12195	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
K08M4_RS12200	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
K08M4_RS12210	COG1966	Carbon starvation protein
K08M4_RS12215	COG3275	phosphorelay sensor kinase activity
K08M4_RS12220	COG3279	Response regulator of the LytR AlgR family
K08M4_RS12225	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K08M4_RS12230	COG1047	Peptidyl-prolyl cis-trans
K08M4_RS12240	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K08M4_RS12245	COG0196	riboflavin kinase activity
K08M4_RS12250	COG0728	peptidoglycan biosynthetic process
K08M4_RS12255	COG0268	Binds directly to 16S ribosomal RNA
K08M4_RS12260	COG0640	Transcriptional regulator
K08M4_RS12265	COG0583	DNA-binding transcription factor activity
K08M4_RS12270	COG1283	sodium-dependent phosphate transmembrane transporter activity
K08M4_RS12275	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
K08M4_RS12280	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K08M4_RS12285	COG0730	response to heat
K08M4_RS12295	COG0494	nUDIX hydrolase
K08M4_RS12335	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K08M4_RS12340	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K08M4_RS12345	COG4974	Belongs to the 'phage' integrase family
K08M4_RS12350	COG0716	FMN binding
K08M4_RS12360	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
K08M4_RS12365	COG0513	Belongs to the DEAD box helicase family
K08M4_RS12370	COG3022	response to hydroperoxide
K08M4_RS12375	COG1115	amino acid carrier protein
K08M4_RS12390	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K08M4_RS12395	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
K08M4_RS12400	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
K08M4_RS12405	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
K08M4_RS12410	COG0083	homoserine kinase activity
K08M4_RS12425	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K08M4_RS12435	COG0745	RESPONSE REGULATOR receiver
K08M4_RS12445	COG2198	Histidine kinase
K08M4_RS12445	COG5002	protein histidine kinase activity
K08M4_RS12445	COG0784	Response regulator, receiver
K08M4_RS12450	COG3706	GGDEF domain
K08M4_RS12450	COG2203	Gaf domain
K08M4_RS12450	COG5001	Diguanylate cyclase
K08M4_RS12450	COG4251	negative regulation of phosphorylation
K08M4_RS12455	COG1242	4 iron, 4 sulfur cluster binding
K08M4_RS12460	COG0067	glutamate synthase
K08M4_RS12460	COG0070	glutamate synthase
K08M4_RS12460	COG0069	glutamate synthase activity
K08M4_RS12470	COG0067	glutamate synthase
K08M4_RS12470	COG0069	glutamate synthase activity
K08M4_RS12470	COG0070	glutamate synthase
K08M4_RS12475	COG0493	'glutamate synthase
K08M4_RS12485	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K08M4_RS12500	COG2860	membrane
K08M4_RS12505	COG0583	DNA-binding transcription factor activity
K08M4_RS12510	COG0730	response to heat
K08M4_RS12515	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K08M4_RS12520	COG0505	Belongs to the CarA family
K08M4_RS12525	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
K08M4_RS12530	COG0494	nUDIX hydrolase
K08M4_RS12535	COG0653	protein targeting
K08M4_RS12540	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
K08M4_RS12545	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K08M4_RS12550	COG0849	cell division
K08M4_RS12555	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K08M4_RS12565	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K08M4_RS12570	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K08M4_RS12575	COG0772	Belongs to the SEDS family
K08M4_RS12580	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K08M4_RS12585	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K08M4_RS12590	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K08M4_RS12595	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K08M4_RS12600	COG0768	penicillin binding
K08M4_RS12605	COG3116	cell division
K08M4_RS12610	COG0275	rRNA processing
K08M4_RS12620	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
K08M4_RS12635	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
K08M4_RS12640	COG2823	Periplasmic or secreted lipoprotein
K08M4_RS12645	COG2969	positive regulation of protein catabolic process
K08M4_RS12650	COG0625	glutathione transferase activity
K08M4_RS12655	COG2857	Cytochrome c1
K08M4_RS12660	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K08M4_RS12665	COG0723	plastoquinol--plastocyanin reductase activity
K08M4_RS12670	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K08M4_RS12675	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
K08M4_RS12680	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
K08M4_RS12685	COG3105	Protein conserved in bacteria
K08M4_RS12695	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K08M4_RS12710	COG3150	esterase
K08M4_RS12720	COG3151	Protein conserved in bacteria
K08M4_RS12725	COG0494	nUDIX hydrolase
K08M4_RS12730	COG1538	Outer membrane efflux protein
K08M4_RS12735	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
K08M4_RS12735	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
K08M4_RS12740	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
K08M4_RS12750	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K08M4_RS12755	COG3025	triphosphatase activity
K08M4_RS12760	COG1392	Phosphate transport regulator
K08M4_RS12765	COG0306	phosphate transporter
K08M4_RS12770	COG4991	sh3 domain protein
K08M4_RS12780	COG3409	Peptidoglycan-binding domain 1 protein
K08M4_RS12780	COG3267	Type II secretory pathway component ExeA
K08M4_RS12785	COG0617	tRNA 3'-terminal CCA addition
K08M4_RS12790	COG1968	undecaprenyl-diphosphatase activity
K08M4_RS12795	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K08M4_RS12800	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
K08M4_RS12805	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
K08M4_RS12810	COG0596	Alpha beta hydrolase
K08M4_RS12815	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K08M4_RS12820	COG0828	Belongs to the bacterial ribosomal protein bS21 family
K08M4_RS12825	COG1610	YqeY-like protein
K08M4_RS12845	COG2873	o-acetylhomoserine
K08M4_RS12850	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K08M4_RS12855	COG1349	DNA-binding transcription factor activity
K08M4_RS12860	COG0469	pyruvate kinase activity
K08M4_RS12880	COG0028	Belongs to the TPP enzyme family
K08M4_RS12885	COG1022	Amp-dependent synthetase and ligase
K08M4_RS12920	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K08M4_RS12925	COG0473	3-isopropylmalate dehydrogenase activity
K08M4_RS12930	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
K08M4_RS12935	COG0066	3-isopropylmalate dehydratase activity
K08M4_RS12950	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
K08M4_RS12955	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
K08M4_RS12960	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K08M4_RS12965	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
K08M4_RS12970	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K08M4_RS12975	COG2967	ApaG domain
K08M4_RS12990	COG3610	response to peptide
K08M4_RS12995	COG2966	Psort location CytoplasmicMembrane, score
K08M4_RS13000	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K08M4_RS13005	COG0211	Belongs to the bacterial ribosomal protein bL27 family
K08M4_RS13010	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K08M4_RS13015	COG0142	geranyltranstransferase activity
K08M4_RS13025	COG0039	L-malate dehydrogenase activity
K08M4_RS13030	COG1438	arginine binding
K08M4_RS13045	COG0589	response to stress
K08M4_RS13050	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K08M4_RS13065	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K08M4_RS13070	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
K08M4_RS13075	COG0312	modulator of DNA gyrase
K08M4_RS13080	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K08M4_RS13085	COG3164	Protein of unknown function
K08M4_RS13095	COG0424	maF-like protein
K08M4_RS13100	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
K08M4_RS13105	COG1792	Involved in formation and maintenance of cell shape
K08M4_RS13110	COG1077	Cell shape determining protein MreB Mrl
K08M4_RS13140	COG2165	general secretion pathway protein
K08M4_RS13145	COG2165	general secretion pathway protein
K08M4_RS13155	COG1459	type II secretion system
K08M4_RS13160	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K08M4_RS13170	COG3409	Peptidoglycan-binding domain 1 protein
K08M4_RS13170	COG3267	Type II secretory pathway component ExeA
K08M4_RS13195	COG2200	EAL domain
K08M4_RS13195	COG2199	diguanylate cyclase activity
K08M4_RS13200	COG0629	single-stranded DNA binding
K08M4_RS13205	COG2197	response regulator
K08M4_RS13215	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K08M4_RS13225	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
K08M4_RS13230	COG0527	aspartate kinase activity
K08M4_RS13260	COG1484	DNA-dependent DNA replication
K08M4_RS13265	COG3335	DDE superfamily endonuclease
K08M4_RS13360	COG0175	sulfate reduction
K08M4_RS13365	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K08M4_RS13370	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K08M4_RS13415	COG0735	belongs to the Fur family
K08M4_RS13425	COG3385	transposase activity
K08M4_RS13430	COG0166	Belongs to the GPI family
K08M4_RS13435	COG0432	Pfam Uncharacterised protein family UPF0047
K08M4_RS13445	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K08M4_RS13460	COG0359	binds to the 23S rRNA
K08M4_RS13470	COG0360	Binds together with S18 to 16S ribosomal RNA
K08M4_RS13475	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K08M4_RS13480	COG0557	exoribonuclease II activity
K08M4_RS13485	COG0402	S-adenosylhomocysteine deaminase activity
K08M4_RS13490	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
K08M4_RS13500	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K08M4_RS13505	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
K08M4_RS13510	COG0330	HflC and HflK could
K08M4_RS13515	COG0330	HflC and HflK could
K08M4_RS13520	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K08M4_RS13525	COG1923	regulation of RNA biosynthetic process
K08M4_RS13530	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K08M4_RS13535	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K08M4_RS13540	COG0860	N-Acetylmuramoyl-L-alanine amidase
K08M4_RS13545	COG0802	atpase or kinase
K08M4_RS13550	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K08M4_RS13635	COG1162	GTPase activity
K08M4_RS13650	COG0471	metal ion transport
K08M4_RS13650	COG0490	domain, Protein
K08M4_RS13665	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
K08M4_RS13670	COG1053	succinate dehydrogenase
K08M4_RS13675	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K08M4_RS13680	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
K08M4_RS13690	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K08M4_RS13695	COG1509	lysine 2,3-aminomutase activity
K08M4_RS13700	COG1285	pathogenesis
K08M4_RS13705	COG2199	diguanylate cyclase activity
K08M4_RS13705	COG2203	Gaf domain
K08M4_RS13720	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
K08M4_RS13730	COG0534	Mate efflux family protein
K08M4_RS13740	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
K08M4_RS13745	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K08M4_RS13800	COG1215	transferase activity, transferring glycosyl groups
K08M4_RS13810	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
K08M4_RS13870	COG0438	transferase activity, transferring glycosyl groups
K08M4_RS13875	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K08M4_RS13880	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
K08M4_RS13895	COG1045	serine acetyltransferase
K08M4_RS13900	COG4942	peptidase
K08M4_RS13925	COG1088	dTDP-glucose 4,6-dehydratase activity
K08M4_RS13935	COG1560	Kdo2-lipid A biosynthetic process
K08M4_RS13945	COG4641	Protein conserved in bacteria
K08M4_RS13945	COG0438	transferase activity, transferring glycosyl groups
K08M4_RS13955	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K08M4_RS13960	COG0859	PFAM glycosyl transferase family 9
K08M4_RS13970	COG3642	lipopolysaccharide core region biosynthetic process
K08M4_RS13985	COG1519	Transferase
K08M4_RS13990	COG0859	PFAM glycosyl transferase family 9
K08M4_RS14000	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K08M4_RS14010	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K08M4_RS14015	COG0227	Belongs to the bacterial ribosomal protein bL28 family
K08M4_RS14020	COG2003	Belongs to the UPF0758 family
K08M4_RS14025	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K08M4_RS14030	COG1309	transcriptional regulator
K08M4_RS14035	COG1560	Kdo2-lipid A biosynthetic process
K08M4_RS14040	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K08M4_RS14045	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
K08M4_RS14050	COG1561	YicC-like family, N-terminal region
K08M4_RS14055	COG1278	Cold shock
K08M4_RS14065	COG0561	phosphatase activity
K08M4_RS14075	COG1454	alcohol dehydrogenase
K08M4_RS14080	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K08M4_RS14090	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K08M4_RS14095	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
K08M4_RS14105	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K08M4_RS14105	COG1263	PTS System
K08M4_RS14120	COG2252	PERMEase
K08M4_RS14125	COG0194	GDP metabolic process
K08M4_RS14130	COG1758	RNA polymerase activity
K08M4_RS14135	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K08M4_RS14140	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K08M4_RS14155	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K08M4_RS14160	COG2183	response to ionizing radiation
K08M4_RS14170	COG0596	Alpha beta hydrolase
K08M4_RS14175	COG1040	competence protein
K08M4_RS14180	COG0316	Belongs to the HesB IscA family
K08M4_RS14180	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
K08M4_RS14185	COG0494	nUDIX hydrolase
K08M4_RS14190	COG1218	3'(2'),5'-bisphosphate nucleotidase
K08M4_RS14200	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
K08M4_RS14205	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
K08M4_RS14210	COG3156	type II secretion system protein K
K08M4_RS14215	COG4795	General secretion pathway protein
K08M4_RS14220	COG2165	general secretion pathway protein
K08M4_RS14225	COG2165	general secretion pathway protein
K08M4_RS14230	COG2165	general secretion pathway protein
K08M4_RS14235	COG1459	type II secretion system
K08M4_RS14240	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K08M4_RS14250	COG3031	protein transport across the cell outer membrane
K08M4_RS14255	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
K08M4_RS14265	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
K08M4_RS14275	COG0456	acetyltransferase
K08M4_RS14280	COG1490	D-aminoacyl-tRNA deacylase activity
K08M4_RS14285	COG1295	ribonuclease BN
K08M4_RS14300	COG1217	gtp-binding protein TYPA
K08M4_RS14310	COG0174	glutamine synthetase
K08M4_RS14320	COG3852	Histidine kinase
K08M4_RS14345	COG3078	GTPase activator activity
K08M4_RS14360	COG0218	Necessary for normal cell division and for the maintenance of normal septation
K08M4_RS14370	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K08M4_RS14370	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K08M4_RS14385	COG0084	hydrolase, TatD family'
K08M4_RS14390	COG0805	protein transport
K08M4_RS14395	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K08M4_RS14400	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K08M4_RS14405	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K08M4_RS14410	COG3165	ubiquinone biosynthetic process from chorismate
K08M4_RS14415	COG2226	methyltransferase
K08M4_RS14420	COG1322	Protein conserved in bacteria
K08M4_RS14430	COG2081	HI0933 family
K08M4_RS14445	COG0732	type I restriction modification DNA specificity domain
K08M4_RS14485	COG2081	HI0933 family
K08M4_RS14510	COG2081	HI0933 family
K08M4_RS14520	COG1528	Iron-storage protein
K08M4_RS14525	COG0589	response to stress
K08M4_RS14540	COG0742	ribosomal rna small subunit methyltransferase
K08M4_RS14545	COG5001	Diguanylate cyclase
K08M4_RS14545	COG5002	protein histidine kinase activity
K08M4_RS14550	COG1522	sequence-specific DNA binding
K08M4_RS14560	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
K08M4_RS14565	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K08M4_RS14595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K08M4_RS14600	COG0601	transmembrane transport
K08M4_RS14605	COG0747	negative chemotaxis
K08M4_RS14650	COG1309	transcriptional regulator
K08M4_RS14655	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K08M4_RS14660	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K08M4_RS14665	COG2960	long-chain fatty acid transporting porin activity
K08M4_RS14670	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K08M4_RS14675	COG0583	DNA-binding transcription factor activity
K08M4_RS14685	COG3335	DDE superfamily endonuclease
K08M4_RS14735	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
K08M4_RS14745	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
K08M4_RS14750	COG0408	coproporphyrinogen oxidase activity
K08M4_RS14755	COG0009	L-threonylcarbamoyladenylate synthase
K08M4_RS14760	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
K08M4_RS14765	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K08M4_RS14770	COG0551	DNA topoisomerase type I activity
K08M4_RS14775	COG2922	Belongs to the Smg family
K08M4_RS14780	COG0758	DNA mediated transformation
K08M4_RS14790	COG0242	peptide deformylase activity
K08M4_RS14795	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K08M4_RS14800	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K08M4_RS14800	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K08M4_RS14805	COG0569	domain protein
K08M4_RS14810	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K08M4_RS14820	COG1272	protein, Hemolysin III
K08M4_RS14825	COG4326	sporulation control protein
K08M4_RS14835	COG3084	Protein conserved in bacteria
K08M4_RS14845	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
K08M4_RS14850	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K08M4_RS14860	COG0606	chelatase, subunit chli
K08M4_RS14870	COG3978	acetolactate synthase activity
K08M4_RS14875	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K08M4_RS14880	COG0129	dihydroxy-acid dehydratase activity
K08M4_RS14890	COG0583	DNA-binding transcription factor activity
K08M4_RS14895	COG2814	Major facilitator Superfamily
K08M4_RS14905	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K08M4_RS14910	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K08M4_RS14915	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K08M4_RS14920	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K08M4_RS14925	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K08M4_RS14930	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K08M4_RS14945	COG3312	ion transport
K08M4_RS14950	COG1475	DNA binding
K08M4_RS14955	COG1192	Involved in chromosome partitioning
K08M4_RS14960	COG0357	Ribosomal RNA small subunit methyltransferase G
K08M4_RS14965	COG0445	tRNA wobble uridine modification
K08M4_RS14975	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K08M4_RS14985	COG0706	membrane insertase activity
K08M4_RS14990	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
K08M4_RS14995	COG0594	ribonuclease P activity
K08M4_RS15000	COG0230	Belongs to the bacterial ribosomal protein bL34 family
K08M4_RS15005	COG1126	abc transporter atp-binding protein
K08M4_RS15030	COG1444	tRNA N-acetyltransferase activity
K08M4_RS15045	COG2194	sulfuric ester hydrolase activity
K08M4_RS15080	COG1132	(ABC) transporter
K08M4_RS15085	COG4399	Belongs to the UPF0754 family
K08M4_RS15105	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K08M4_RS15130	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K08M4_RS15140	COG0259	pyridoxamine-phosphate oxidase activity
K08M4_RS15180	COG2205	protein histidine kinase activity
K08M4_RS15185	COG0745	RESPONSE REGULATOR receiver
K08M4_RS15195	COG1309	transcriptional regulator
K08M4_RS15200	COG1012	belongs to the aldehyde dehydrogenase family
K08M4_RS15220	COG4175	Glycine betaine
K08M4_RS15225	COG1846	Transcriptional regulator
K08M4_RS15240	COG0456	acetyltransferase
K08M4_RS15245	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K08M4_RS15255	COG0527	aspartate kinase activity
K08M4_RS15285	COG1597	lipid kinase activity
K08M4_RS15285	COG1803	Methylglyoxal synthase
K08M4_RS15290	COG0668	transmembrane transport
K08M4_RS15320	COG0628	permease
K08M4_RS15335	COG0800	Aldolase
K08M4_RS15340	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K08M4_RS15345	COG1263	PTS System
K08M4_RS15345	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K08M4_RS15360	COG2188	Transcriptional regulator
K08M4_RS15370	COG0110	maltose O-acetyltransferase activity
K08M4_RS15375	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K08M4_RS15385	COG2207	Transcriptional regulator
K08M4_RS15390	COG2814	Major facilitator Superfamily
K08M4_RS15410	COG3547	Transposase (IS116 IS110 IS902 family)
K08M4_RS15425	COG2015	COG2015, Alkyl sulfatase and related hydrolases
K08M4_RS15440	COG0346	lactoylglutathione lyase activity
K08M4_RS15445	COG2723	6-phospho-beta-galactosidase activity
K08M4_RS15450	COG1609	Transcriptional regulator
K08M4_RS15455	COG0110	maltose O-acetyltransferase activity
K08M4_RS15460	COG2814	Major facilitator Superfamily
K08M4_RS15465	COG0583	DNA-binding transcription factor activity
K08M4_RS15475	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
K08M4_RS15485	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K08M4_RS15520	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
K08M4_RS15525	COG1349	DNA-binding transcription factor activity
K08M4_RS15530	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
K08M4_RS15535	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K08M4_RS15560	COG2994	toxin metabolic process
K08M4_RS15565	COG1073	alpha beta
K08M4_RS15565	COG3064	Membrane
K08M4_RS15565	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
K08M4_RS15575	COG0583	DNA-binding transcription factor activity
K08M4_RS15580	COG0798	PFAM Bile acid sodium symporter
K08M4_RS15595	COG1309	transcriptional regulator
K08M4_RS15600	COG0561	phosphatase activity
K08M4_RS15615	COG4974	Belongs to the 'phage' integrase family
K08M4_RS15625	COG3214	Protein conserved in bacteria
K08M4_RS15675	COG0561	phosphatase activity
K08M4_RS15680	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
K08M4_RS15685	COG3623	hexulose-6-phosphate isomerase
K08M4_RS15695	COG1929	Belongs to the glycerate kinase type-1 family
K08M4_RS15700	COG0753	catalase activity
K08M4_RS15705	COG4667	esterase of the alpha-beta hydrolase superfamily
K08M4_RS15710	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K08M4_RS15720	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K08M4_RS15725	COG0204	Acyl-transferase
K08M4_RS15730	COG2384	SAM-dependent methyltransferase
K08M4_RS15770	COG0366	Alpha amylase catalytic
K08M4_RS15840	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
K08M4_RS15845	COG1162	GTPase activity
K08M4_RS15855	COG1999	signal sequence binding
K08M4_RS15875	COG0058	SHG alpha-glucan phosphorylase activity
K08M4_RS15880	COG1640	4-alpha-glucanotransferase
K08M4_RS15885	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
K08M4_RS15895	COG1122	ATPase activity
K08M4_RS15900	COG4720	Psort location CytoplasmicMembrane, score
K08M4_RS15905	COG1566	PFAM secretion protein HlyD family protein
K08M4_RS15935	COG0813	purine-nucleoside phosphorylase activity
K08M4_RS15940	COG1388	LysM domain
K08M4_RS15940	COG1376	ErfK ybiS ycfS ynhG family protein
K08M4_RS15950	COG0513	Belongs to the DEAD box helicase family
K08M4_RS15955	COG3240	lipase activity
K08M4_RS15960	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
K08M4_RS15970	COG0840	transmembrane signaling receptor activity
K08M4_RS15980	COG0573	inorganic phosphate transmembrane transporter activity
K08M4_RS15985	COG0581	inorganic phosphate transmembrane transporter activity
K08M4_RS15990	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K08M4_RS15995	COG3706	GGDEF domain
K08M4_RS16005	COG2304	oxidoreductase activity
K08M4_RS16010	COG2304	oxidoreductase activity
K08M4_RS16025	COG0714	Associated with various cellular activities
K08M4_RS16030	COG0840	transmembrane signaling receptor activity
K08M4_RS16040	COG3385	transposase activity
K08M4_RS16045	COG3842	ATPase activity
K08M4_RS16055	COG1175	transmembrane transport
K08M4_RS16060	COG3833	ABC-type maltose transport systems, permease component
K08M4_RS16075	COG3385	transposase activity
K08M4_RS16100	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K08M4_RS16105	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K08M4_RS16115	COG0668	transmembrane transport
K08M4_RS16135	COG2239	Acts as a magnesium transporter
K08M4_RS16145	COG0387	Pfam Sodium calcium exchanger
K08M4_RS16150	COG0583	DNA-binding transcription factor activity
K08M4_RS16160	COG0577	efflux transmembrane transporter activity
K08M4_RS16165	COG1136	(ABC) transporter
K08M4_RS16190	COG3706	GGDEF domain
K08M4_RS16240	COG1012	belongs to the aldehyde dehydrogenase family
K08M4_RS16255	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K08M4_RS16265	COG2354	Protein conserved in bacteria
K08M4_RS16270	COG0418	dihydroorotase activity
K08M4_RS16280	COG0633	Ferredoxin
K08M4_RS16280	COG3217	Mosc domain protein beta barrel domain protein
K08M4_RS16285	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
K08M4_RS16335	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
K08M4_RS16340	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K08M4_RS16350	COG0848	biopolymer transport protein
K08M4_RS16355	COG0811	peptide transport
K08M4_RS16360	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
K08M4_RS16370	COG3721	Heme iron utilization protein
K08M4_RS16375	COG0748	coenzyme F420 binding
K08M4_RS16380	COG0784	Response regulator, receiver
K08M4_RS16380	COG0835	chemotaxis
K08M4_RS16385	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K08M4_RS16390	COG0366	Alpha amylase catalytic
K08M4_RS16400	COG3314	Sporulation integral membrane protein YlbJ
K08M4_RS16425	COG0739	heme binding
K08M4_RS16430	COG5001	Diguanylate cyclase
K08M4_RS16435	COG0583	DNA-binding transcription factor activity
K08M4_RS16440	COG2814	Major facilitator Superfamily
K08M4_RS16470	COG0697	spore germination
K08M4_RS16475	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K08M4_RS16485	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K08M4_RS16490	COG3037	sugar-specific permease SgaT UlaA
K08M4_RS16510	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K08M4_RS16520	COG4106	trans-aconitate 2-methyltransferase activity
K08M4_RS16535	COG0513	Belongs to the DEAD box helicase family
K08M4_RS16550	COG3706	GGDEF domain
K08M4_RS16555	COG1278	Cold shock
K08M4_RS16560	COG0402	S-adenosylhomocysteine deaminase activity
K08M4_RS16585	COG4413	Urea transporter
K08M4_RS16600	COG0531	amino acid
K08M4_RS16615	COG1280	lysine exporter protein (LysE YggA)
K08M4_RS16630	COG1151	hydroxylamine reductase activity
K08M4_RS16635	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K08M4_RS16650	COG2926	Belongs to the UPF0265 family
K08M4_RS16660	COG3132	Protein of unknown function, DUF480
K08M4_RS16665	COG2827	Endonuclease containing a URI domain
K08M4_RS16675	COG2205	protein histidine kinase activity
K08M4_RS16675	COG0784	Response regulator, receiver
K08M4_RS16695	COG0443	Heat shock 70 kDa protein
K08M4_RS16705	COG0179	Fumarylacetoacetate (FAA) hydrolase
K08M4_RS16710	COG1280	lysine exporter protein (LysE YggA)
K08M4_RS16715	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K08M4_RS16720	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K08M4_RS16720	COG1565	acr, cog1565
K08M4_RS16725	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K08M4_RS16735	COG1845	cytochrome c oxidase, subunit III
K08M4_RS16755	COG1612	heme a metabolic process
K08M4_RS16760	COG0109	protoheme IX farnesyltransferase activity
K08M4_RS16775	COG3530	Putative quorum-sensing-regulated virulence factor
K08M4_RS16795	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
K08M4_RS16800	COG2944	sequence-specific DNA binding
K08M4_RS16835	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K08M4_RS16840	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K08M4_RS16850	COG0668	transmembrane transport
K08M4_RS16855	COG0569	domain protein
K08M4_RS16860	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K08M4_RS16865	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K08M4_RS16865	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K08M4_RS16870	COG1765	OsmC-like protein
K08M4_RS16875	COG2885	chlorophyll binding
K08M4_RS16885	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K08M4_RS16895	COG1840	ABC-type Fe3 transport system, periplasmic component
K08M4_RS16900	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K08M4_RS16905	COG3842	ATPase activity
K08M4_RS16925	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
K08M4_RS16935	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K08M4_RS16940	COG3265	gluconokinase activity
K08M4_RS16945	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
K08M4_RS16955	COG1609	Transcriptional regulator
K08M4_RS16965	COG3104	oligopeptide transport
K08M4_RS16970	COG1760	l-serine dehydratase
K08M4_RS17005	COG1132	(ABC) transporter
K08M4_RS17010	COG1132	(ABC) transporter
K08M4_RS17020	COG0739	heme binding
K08M4_RS17025	COG0393	Putative heavy-metal-binding
K08M4_RS17035	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
K08M4_RS17055	COG0346	lactoylglutathione lyase activity
K08M4_RS17070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K08M4_RS17080	COG1136	(ABC) transporter
K08M4_RS17080	COG0577	efflux transmembrane transporter activity
K08M4_RS17085	COG1136	(ABC) transporter
K08M4_RS17085	COG0577	efflux transmembrane transporter activity
K08M4_RS17090	COG0577	efflux transmembrane transporter activity
K08M4_RS17090	COG1136	(ABC) transporter
K08M4_RS17100	COG2200	EAL domain
K08M4_RS17105	COG0156	8-amino-7-oxononanoate synthase activity
K08M4_RS17110	COG1063	alcohol dehydrogenase
K08M4_RS17120	COG2249	NAD(P)H dehydrogenase (quinone) activity
K08M4_RS17140	COG1454	alcohol dehydrogenase
K08M4_RS17145	COG1011	Hydrolase
K08M4_RS17155	COG3706	GGDEF domain
K08M4_RS17155	COG2203	Gaf domain
K08M4_RS17155	COG5001	Diguanylate cyclase
K08M4_RS17155	COG4251	negative regulation of phosphorylation
K08M4_RS17175	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K08M4_RS17180	COG3385	transposase activity
K08M4_RS17200	COG1522	sequence-specific DNA binding
K08M4_RS17205	COG0840	transmembrane signaling receptor activity
K08M4_RS17210	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K08M4_RS17230	COG0583	DNA-binding transcription factor activity
K08M4_RS17250	COG4964	Belongs to the GSP D family
K08M4_RS17305	COG4251	negative regulation of phosphorylation
K08M4_RS17305	COG2203	Gaf domain
K08M4_RS17305	COG3706	GGDEF domain
K08M4_RS17305	COG5001	Diguanylate cyclase
K08M4_RS17310	COG2897	thiosulfate sulfurtransferase activity
K08M4_RS17340	COG0302	gtp cyclohydrolase
K08M4_RS17355	COG4681	YaeQ
K08M4_RS17360	COG1278	Cold shock
K08M4_RS17370	COG2133	pyrroloquinoline quinone binding
K08M4_RS17380	COG1120	ATPase activity
K08M4_RS17390	COG3708	Transcriptional regulator
K08M4_RS17390	COG2207	Transcriptional regulator
K08M4_RS17410	COG1024	Enoyl-CoA hydratase
K08M4_RS17425	COG0446	pyridine nucleotide-disulphide oxidoreductase
K08M4_RS17425	COG1902	pentaerythritol trinitrate reductase activity
K08M4_RS17440	COG1132	(ABC) transporter
K08M4_RS17515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K08M4_RS17520	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K08M4_RS17555	COG2824	Alkylphosphonate utilization operon protein PhnA
K08M4_RS17570	COG0765	amino acid transport
K08M4_RS17575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K08M4_RS17580	COG0765	amino acid transport
K08M4_RS17585	COG1126	abc transporter atp-binding protein
K08M4_RS17590	COG1979	alcohol dehydrogenase
K08M4_RS17595	COG2207	Transcriptional regulator
K08M4_RS17620	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K08M4_RS17630	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K08M4_RS17645	COG2199	diguanylate cyclase activity
K08M4_RS17665	COG1686	Belongs to the peptidase S11 family
K08M4_RS17675	COG0564	pseudouridine synthase activity
K08M4_RS17685	COG2130	NADP-dependent
K08M4_RS17690	COG1309	transcriptional regulator
K08M4_RS17695	COG0545	Peptidyl-prolyl cis-trans isomerase
K08M4_RS17720	COG3604	Transcriptional regulator
K08M4_RS17725	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K08M4_RS17725	COG1017	nitric oxide dioxygenase activity
K08M4_RS17735	COG0038	chloride channel
K08M4_RS17740	COG0523	cobalamin synthesis protein
K08M4_RS17745	COG0513	Belongs to the DEAD box helicase family
K08M4_RS17750	COG1280	lysine exporter protein (LysE YggA)
K08M4_RS17775	COG0745	RESPONSE REGULATOR receiver
K08M4_RS17825	COG3005	denitrification pathway
K08M4_RS17830	COG3043	anaerobic respiration
K08M4_RS17835	COG0243	molybdopterin cofactor binding
K08M4_RS17850	COG3850	Histidine kinase
K08M4_RS17855	COG2197	response regulator
K08M4_RS17860	COG3069	C4-dicarboxylate transmembrane transporter activity
K08M4_RS17900	COG3188	usher protein
K08M4_RS17925	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
K08M4_RS17930	COG0494	nUDIX hydrolase
K08M4_RS17940	COG2425	protein containing a von Willebrand factor type A (vWA) domain
K08M4_RS17995	COG1858	cytochrome C peroxidase
K08M4_RS18000	COG1858	cytochrome C peroxidase
K08M4_RS18025	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K08M4_RS18035	COG2116	formate transmembrane transporter activity
K08M4_RS18040	COG1648	precorrin-2 dehydrogenase activity
K08M4_RS18040	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K08M4_RS18055	COG0745	RESPONSE REGULATOR receiver
K08M4_RS18060	COG2205	protein histidine kinase activity
K08M4_RS18065	COG1301	dicarboxylic acid transport
K08M4_RS18070	COG4774	siderophore transport
K08M4_RS18080	COG0811	peptide transport
K08M4_RS18085	COG0811	peptide transport
K08M4_RS18090	COG0848	biopolymer transport protein
K08M4_RS18210	COG0745	RESPONSE REGULATOR receiver
K08M4_RS18215	COG2205	protein histidine kinase activity
K08M4_RS18220	COG1301	dicarboxylic acid transport
K08M4_RS18225	COG4774	siderophore transport
K08M4_RS18235	COG0811	peptide transport
K08M4_RS18240	COG0811	peptide transport
K08M4_RS18245	COG0848	biopolymer transport protein
K08M4_RS18295	COG0803	Belongs to the bacterial solute-binding protein 9 family
K08M4_RS18300	COG1121	(ABC) transporter
K08M4_RS18305	COG1321	iron dependent repressor
K08M4_RS18305	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K08M4_RS18325	COG0534	Mate efflux family protein
K08M4_RS18360	COG0318	PFAM AMP-dependent synthetase and ligase
K08M4_RS18370	COG3118	belongs to the thioredoxin family
K08M4_RS18375	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K08M4_RS18400	COG1328	CTP reductase activity
K08M4_RS18405	COG0602	queuosine metabolic process
K08M4_RS18410	COG0534	Mate efflux family protein
K08M4_RS18425	COG4067	protein conserved in archaea
K08M4_RS18425	COG0189	ligase activity
K08M4_RS18430	COG0488	(ABC) transporter
K08M4_RS18455	COG0725	ABC transporter, periplasmic molybdate-binding protein
K08M4_RS18460	COG4149	molybdate abc transporter
K08M4_RS18475	COG5001	Diguanylate cyclase
K08M4_RS18475	COG2203	Gaf domain
K08M4_RS18475	COG3706	GGDEF domain
K08M4_RS18475	COG4251	negative regulation of phosphorylation
K08M4_RS18485	COG3706	GGDEF domain
K08M4_RS18500	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
K08M4_RS18505	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
K08M4_RS18530	COG3140	Belongs to the UPF0181 family
K08M4_RS18535	COG3706	GGDEF domain
K08M4_RS18545	COG2801	Transposase and inactivated derivatives
K08M4_RS18550	COG0023	Translation Initiation Factor
K08M4_RS18565	COG1181	Belongs to the D-alanine--D-alanine ligase family
K08M4_RS18570	COG3266	domain, Protein
K08M4_RS18575	COG0045	succinate-CoA ligase (ADP-forming) activity
K08M4_RS18575	COG1042	CoA-binding domain protein
K08M4_RS18575	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K08M4_RS18580	COG0583	DNA-binding transcription factor activity
K08M4_RS18585	COG4771	TonB-dependent receptor
K08M4_RS18585	COG1629	transport
K08M4_RS18600	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
K08M4_RS18605	COG1984	allophanate hydrolase subunit 2
K08M4_RS18615	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
K08M4_RS18620	COG4181	ATPase activity
K08M4_RS18630	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K08M4_RS18635	COG1716	ATPase activity
K08M4_RS18635	COG5001	Diguanylate cyclase
K08M4_RS18645	COG0768	penicillin binding
K08M4_RS18650	COG0484	heat shock protein binding
K08M4_RS18670	COG4533	DNA binding
K08M4_RS18680	COG2050	protein possibly involved in aromatic compounds catabolism
K08M4_RS18685	COG0501	Belongs to the peptidase M48B family
K08M4_RS18695	COG2067	long-chain fatty acid transport protein
K08M4_RS18700	COG2267	carboxylic ester hydrolase activity
K08M4_RS18715	COG0583	DNA-binding transcription factor activity
K08M4_RS18730	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
K08M4_RS18740	COG2985	domain, Protein
K08M4_RS18760	COG1566	PFAM secretion protein HlyD family protein
K08M4_RS18780	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K08M4_RS18790	COG0513	Belongs to the DEAD box helicase family
K08M4_RS18805	COG0861	Integral membrane protein TerC family
K08M4_RS18810	COG0737	Belongs to the 5'-nucleotidase family
K08M4_RS18815	COG3593	DNA synthesis involved in DNA repair
K08M4_RS18825	COG0583	DNA-binding transcription factor activity
K08M4_RS18830	COG2116	formate transmembrane transporter activity
K08M4_RS18835	COG2353	YceI-like domain
K08M4_RS18840	COG3038	cytochrome b561
K08M4_RS18855	COG2200	EAL domain
K08M4_RS18880	COG0513	Belongs to the DEAD box helicase family
K08M4_RS18890	COG0814	amino acid
K08M4_RS18895	COG0840	transmembrane signaling receptor activity
K08M4_RS18905	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K08M4_RS18910	COG3437	response regulator, receiver
K08M4_RS18910	COG0784	Response regulator, receiver
K08M4_RS18925	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K08M4_RS18930	COG2759	Belongs to the formate--tetrahydrofolate ligase family
K08M4_RS18940	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K08M4_RS18980	COG0509	glycine decarboxylation via glycine cleavage system
K08M4_RS19000	COG2184	nucleotidyltransferase activity
K08M4_RS19020	COG4974	Belongs to the 'phage' integrase family
K08M4_RS19035	COG0517	IMP dehydrogenase activity
K08M4_RS19045	COG0534	Mate efflux family protein
K08M4_RS19050	COG1280	lysine exporter protein (LysE YggA)
K08M4_RS19085	COG2807	transmembrane transport
K08M4_RS19090	COG5002	protein histidine kinase activity
K08M4_RS19160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K08M4_RS19165	COG2205	protein histidine kinase activity
K08M4_RS19165	COG0784	Response regulator, receiver
K08M4_RS19170	COG1538	Outer membrane efflux protein
K08M4_RS19175	COG1132	(ABC) transporter
K08M4_RS19210	COG0641	radical SAM
K08M4_RS19225	COG0583	DNA-binding transcription factor activity
K08M4_RS19255	COG0714	Associated with various cellular activities
K08M4_RS19265	COG3119	arylsulfatase activity
K08M4_RS19270	COG3119	arylsulfatase activity
K08M4_RS19275	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
K08M4_RS19280	COG0456	acetyltransferase
K08M4_RS19285	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
K08M4_RS19305	COG0384	phenazine biosynthesis protein PhzF
K08M4_RS19310	COG1280	lysine exporter protein (LysE YggA)
K08M4_RS19320	COG3300	MHYT domain
K08M4_RS19320	COG5001	Diguanylate cyclase
K08M4_RS19340	COG3278	Belongs to the heme-copper respiratory oxidase family
K08M4_RS19375	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K08M4_RS19390	COG1012	belongs to the aldehyde dehydrogenase family
K08M4_RS19400	COG0583	DNA-binding transcription factor activity
K08M4_RS19410	COG4172	Belongs to the ABC transporter superfamily
K08M4_RS19415	COG4239	(ABC) transporter, permease
K08M4_RS19420	COG4174	ABC transporter (Permease)
K08M4_RS19425	COG4166	transmembrane transport
K08M4_RS19440	COG1869	D-ribose catabolic process
K08M4_RS19445	COG1129	ABC transporter
K08M4_RS19450	COG1172	Belongs to the binding-protein-dependent transport system permease family
K08M4_RS19455	COG1879	ABC-type sugar transport system periplasmic component
K08M4_RS19460	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K08M4_RS19465	COG1609	Transcriptional regulator
K08M4_RS19495	COG0330	HflC and HflK could
K08M4_RS19515	COG0243	molybdopterin cofactor binding
K08M4_RS19520	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K08M4_RS19530	COG2223	nitrite transmembrane transporter activity
K08M4_RS19535	COG0515	serine threonine protein kinase
K08M4_RS19535	COG2815	serine threonine protein kinase
K08M4_RS19540	COG1609	Transcriptional regulator
K08M4_RS19545	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K08M4_RS19545	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K08M4_RS19550	COG1105	Belongs to the carbohydrate kinase PfkB family
K08M4_RS19555	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
K08M4_RS19555	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K08M4_RS19555	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K08M4_RS19565	COG0625	glutathione transferase activity
K08M4_RS19600	COG1879	ABC-type sugar transport system periplasmic component
K08M4_RS19605	COG1803	Methylglyoxal synthase
K08M4_RS19615	COG0210	DNA helicase
K08M4_RS19620	COG1289	transmembrane transporter activity
K08M4_RS19640	COG0583	DNA-binding transcription factor activity
K08M4_RS19645	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K08M4_RS19650	COG1328	CTP reductase activity
K08M4_RS19655	COG3385	transposase activity
K08M4_RS19660	COG2814	Major facilitator Superfamily
K08M4_RS19665	COG0583	DNA-binding transcription factor activity
K08M4_RS19670	COG2205	protein histidine kinase activity
K08M4_RS19670	COG0784	Response regulator, receiver
K08M4_RS19675	COG3437	response regulator, receiver
K08M4_RS19680	COG4604	ABC transporter, ATP-binding protein
K08M4_RS19685	COG4605	iron ion homeostasis
K08M4_RS19690	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K08M4_RS19695	COG4607	ABC-type enterochelin transport system periplasmic component
K08M4_RS19720	COG0628	permease
K08M4_RS19740	COG3706	GGDEF domain
K08M4_RS19750	COG0583	DNA-binding transcription factor activity
K08M4_RS19770	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
K08M4_RS19775	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
K08M4_RS19780	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K08M4_RS19785	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K08M4_RS19790	COG1116	anion transmembrane transporter activity
K08M4_RS19795	COG0351	phosphomethylpyrimidine kinase
K08M4_RS19800	COG0697	spore germination
K08M4_RS19835	COG2199	diguanylate cyclase activity
K08M4_RS19835	COG2203	Gaf domain
K08M4_RS19845	COG3344	reverse transcriptase
K08M4_RS19860	COG3335	DDE superfamily endonuclease
K08M4_RS19885	COG0516	GMP reductase activity
K08M4_RS19890	COG3646	Phage regulatory protein
K08M4_RS20015	COG4695	Portal protein
K08M4_RS20110	COG0582	viral genome integration into host DNA
K08M4_RS20115	COG0516	GMP reductase activity
K08M4_RS20125	COG4566	intracellular signal transduction
K08M4_RS20135	COG0534	Mate efflux family protein
K08M4_RS20140	COG0583	DNA-binding transcription factor activity
K08M4_RS20165	COG0604	alcohol dehydrogenase
K08M4_RS20180	COG1120	ATPase activity
K08M4_RS20185	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K08M4_RS20190	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K08M4_RS20195	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
K08M4_RS20200	COG4772	TonB-dependent receptor
K08M4_RS20215	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K08M4_RS20220	COG0513	Belongs to the DEAD box helicase family
K08M4_RS20225	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
K08M4_RS20240	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K08M4_RS20275	COG2195	Cleaves the N-terminal amino acid of tripeptides
K08M4_RS20280	COG0667	Aldo Keto reductase
K08M4_RS20285	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K08M4_RS20290	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
K08M4_RS20295	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
K08M4_RS20310	COG0513	Belongs to the DEAD box helicase family
K08M4_RS20320	COG2176	DNA-directed DNA polymerase activity
K08M4_RS20335	COG0513	Belongs to the DEAD box helicase family
K08M4_RS20340	COG4989	oxidoreductase activity
K08M4_RS20365	COG0668	transmembrane transport
K08M4_RS20375	COG4232	protein-disulfide reductase activity
K08M4_RS20380	COG3118	belongs to the thioredoxin family
K08M4_RS20385	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
K08M4_RS20390	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K08M4_RS20395	COG2205	protein histidine kinase activity
K08M4_RS20400	COG0745	RESPONSE REGULATOR receiver
K08M4_RS20410	COG5001	Diguanylate cyclase
K08M4_RS20420	COG1131	(ABC) transporter
K08M4_RS20445	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K08M4_RS20445	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K08M4_RS20455	COG0564	pseudouridine synthase activity
K08M4_RS20485	COG0747	negative chemotaxis
K08M4_RS20490	COG0189	ligase activity
K08M4_RS20495	COG4067	protein conserved in archaea
K08M4_RS20495	COG0189	ligase activity
K08M4_RS20515	COG1175	transmembrane transport
K08M4_RS20520	COG0395	ABC-type sugar transport system, permease component
K08M4_RS20525	COG3842	ATPase activity
K08M4_RS20530	COG0584	glycerophosphoryl diester phosphodiesterase
K08M4_RS20555	COG0673	inositol 2-dehydrogenase activity
K08M4_RS20565	COG2999	glutathione oxidoreductase activity
K08M4_RS20580	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
K08M4_RS20590	COG0534	Mate efflux family protein
K08M4_RS20595	COG2964	Protein conserved in bacteria
K08M4_RS20610	COG0446	pyridine nucleotide-disulphide oxidoreductase
K08M4_RS20635	COG3335	DDE superfamily endonuclease
K08M4_RS20700	COG1901	pseudouridine methyltransferase
K08M4_RS20710	COG1215	transferase activity, transferring glycosyl groups
K08M4_RS20730	COG1595	DNA-templated transcription, initiation
K08M4_RS20735	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K08M4_RS20760	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K08M4_RS20765	COG4166	transmembrane transport
K08M4_RS20770	COG0601	transmembrane transport
K08M4_RS20775	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K08M4_RS20780	COG4172	Belongs to the ABC transporter superfamily
K08M4_RS20795	COG0583	DNA-binding transcription factor activity
K08M4_RS20800	COG4221	oxidoreductase activity
K08M4_RS20810	COG2358	TRAP transporter, solute receptor (TAXI family
K08M4_RS20820	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K08M4_RS20835	COG3639	organic phosphonate transmembrane transporter activity
K08M4_RS20840	COG3639	organic phosphonate transmembrane transporter activity
K08M4_RS20845	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
K08M4_RS20880	COG4948	Mandelate Racemase Muconate Lactonizing
K08M4_RS20890	COG0583	DNA-binding transcription factor activity
K08M4_RS20900	COG0366	Alpha amylase catalytic
K08M4_RS20915	COG0583	DNA-binding transcription factor activity
K08M4_RS20935	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K08M4_RS20940	COG0814	amino acid
K08M4_RS20945	COG1846	Transcriptional regulator
K08M4_RS20950	COG1764	response to oxidative stress
K08M4_RS20955	COG0840	transmembrane signaling receptor activity
K08M4_RS20965	COG1309	transcriptional regulator
K08M4_RS20970	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K08M4_RS20975	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K08M4_RS20985	COG2207	Transcriptional regulator
K08M4_RS20990	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K08M4_RS20990	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K08M4_RS20990	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K08M4_RS21005	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K08M4_RS21010	COG4166	transmembrane transport
K08M4_RS21025	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K08M4_RS21030	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
K08M4_RS21035	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
K08M4_RS21050	COG1012	belongs to the aldehyde dehydrogenase family
K08M4_RS21055	COG3284	Transcriptional regulator
K08M4_RS21060	COG0840	transmembrane signaling receptor activity
K08M4_RS21070	COG0625	glutathione transferase activity
K08M4_RS21105	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
K08M4_RS21110	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K08M4_RS21115	COG1418	mRNA catabolic process
K08M4_RS21160	COG1846	Transcriptional regulator
K08M4_RS21165	COG0697	spore germination
K08M4_RS21195	COG1067	ATP-dependent peptidase activity
K08M4_RS21205	COG4172	Belongs to the ABC transporter superfamily
K08M4_RS21220	COG1609	Transcriptional regulator
K08M4_RS21230	COG2017	converts alpha-aldose to the beta-anomer
K08M4_RS21235	COG3459	Glycosyltransferase 36 associated
K08M4_RS21240	COG3842	ATPase activity
K08M4_RS21245	COG2723	6-phospho-beta-galactosidase activity
K08M4_RS21250	COG0395	ABC-type sugar transport system, permease component
K08M4_RS21280	COG1505	serine-type exopeptidase activity
K08M4_RS21285	COG0583	DNA-binding transcription factor activity
K08M4_RS21290	COG1620	l-lactate permease
K08M4_RS21295	COG1304	FMN binding
K08M4_RS21315	COG2207	Transcriptional regulator
K08M4_RS21315	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K08M4_RS21320	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K08M4_RS21325	COG1054	Belongs to the UPF0176 family
K08M4_RS21340	COG1482	cell wall glycoprotein biosynthetic process
K08M4_RS21345	COG2271	Major facilitator Superfamily
K08M4_RS21350	COG3851	Histidine kinase
K08M4_RS21355	COG2197	response regulator
K08M4_RS21385	COG1741	Belongs to the pirin family
K08M4_RS21390	COG3123	guanosine phosphorylase activity
K08M4_RS21405	COG0596	Alpha beta hydrolase
K08M4_RS21445	COG3788	relative of glutathione S-transferase, MAPEG superfamily
K08M4_RS21450	COG0700	Nucleoside recognition
K08M4_RS21455	COG3366	ferrous iron transmembrane transporter activity
K08M4_RS21460	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
K08M4_RS21470	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K08M4_RS21475	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
K08M4_RS21495	COG0363	glucosamine-6-phosphate deaminase activity
K08M4_RS21520	COG0446	pyridine nucleotide-disulphide oxidoreductase
K08M4_RS21525	COG0786	glutamate:sodium symporter activity
K08M4_RS21550	COG1595	DNA-templated transcription, initiation
K08M4_RS21555	COG3806	Anti-sigma factor
K08M4_RS21565	COG0415	Belongs to the DNA photolyase family
K08M4_RS21590	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K08M4_RS21615	COG0724	RNA recognition motif
K08M4_RS21635	COG2190	(PTS) system
K08M4_RS21635	COG1263	PTS System
K08M4_RS21635	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K08M4_RS21645	COG2205	protein histidine kinase activity
K08M4_RS21660	COG1028	Short-chain dehydrogenase reductase Sdr
K08M4_RS21665	COG2814	Major facilitator Superfamily
K08M4_RS21670	COG1902	pentaerythritol trinitrate reductase activity
K08M4_RS21685	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K08M4_RS21690	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K08M4_RS21700	COG0612	Peptidase, M16
K08M4_RS21705	COG0612	Peptidase, M16
K08M4_RS21710	COG3279	Response regulator of the LytR AlgR family
K08M4_RS21715	COG3275	phosphorelay sensor kinase activity
K08M4_RS21730	COG4591	ABC-type transport system involved in lipoprotein release permease component
K08M4_RS21750	COG0583	DNA-binding transcription factor activity
K08M4_RS21770	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K08M4_RS21775	COG2084	Dehydrogenase
K08M4_RS21780	COG0217	transcriptional regulatory protein
K08M4_RS21795	COG3186	Phenylalanine-4-hydroxylase
K08M4_RS21800	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K08M4_RS21815	COG0625	glutathione transferase activity
K08M4_RS21825	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
K08M4_RS21860	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K08M4_RS21860	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
K08M4_RS21870	COG0444	Belongs to the ABC transporter superfamily
K08M4_RS21875	COG4608	Belongs to the ABC transporter superfamily