locus-tag	class	description
K09K1_RS00010	COG4128	Pfam Zonular occludens toxin
K09K1_RS00070	COG4128	Pfam Zonular occludens toxin
K09K1_RS00130	COG4128	Pfam Zonular occludens toxin
K09K1_RS00180	COG0023	Translation Initiation Factor
K09K1_RS00190	COG1181	Belongs to the D-alanine--D-alanine ligase family
K09K1_RS00205	COG0045	succinate-CoA ligase (ADP-forming) activity
K09K1_RS00205	COG1042	CoA-binding domain protein
K09K1_RS00205	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K09K1_RS00210	COG0583	DNA-binding transcription factor activity
K09K1_RS00225	COG5001	Diguanylate cyclase
K09K1_RS00225	COG3447	MASE1 domain protein
K09K1_RS00225	COG5002	protein histidine kinase activity
K09K1_RS00230	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
K09K1_RS00235	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
K09K1_RS00240	COG1984	allophanate hydrolase subunit 2
K09K1_RS00250	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
K09K1_RS00255	COG4181	ATPase activity
K09K1_RS00265	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K09K1_RS00270	COG5001	Diguanylate cyclase
K09K1_RS00270	COG3300	MHYT domain
K09K1_RS00305	COG4533	DNA binding
K09K1_RS00315	COG2050	protein possibly involved in aromatic compounds catabolism
K09K1_RS00330	COG2067	long-chain fatty acid transport protein
K09K1_RS00335	COG2267	carboxylic ester hydrolase activity
K09K1_RS00355	COG0861	Integral membrane protein TerC family
K09K1_RS00360	COG0737	Belongs to the 5'-nucleotidase family
K09K1_RS00365	COG3593	DNA synthesis involved in DNA repair
K09K1_RS00375	COG0583	DNA-binding transcription factor activity
K09K1_RS00380	COG2116	formate transmembrane transporter activity
K09K1_RS00385	COG2353	YceI-like domain
K09K1_RS00390	COG3038	cytochrome b561
K09K1_RS00410	COG0513	Belongs to the DEAD box helicase family
K09K1_RS00415	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
K09K1_RS00425	COG0840	transmembrane signaling receptor activity
K09K1_RS00435	COG0546	phosphoglycolate phosphatase activity
K09K1_RS00450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K09K1_RS00455	COG2759	Belongs to the formate--tetrahydrofolate ligase family
K09K1_RS00460	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K09K1_RS00475	COG2207	Transcriptional regulator
K09K1_RS00480	COG1979	alcohol dehydrogenase
K09K1_RS00490	COG1126	abc transporter atp-binding protein
K09K1_RS00495	COG0765	amino acid transport
K09K1_RS00500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K09K1_RS00505	COG0765	amino acid transport
K09K1_RS00510	COG2203	Gaf domain
K09K1_RS00510	COG2199	diguanylate cyclase activity
K09K1_RS00510	COG2200	EAL domain
K09K1_RS00525	COG1609	Transcriptional regulator
K09K1_RS00530	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K09K1_RS00530	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K09K1_RS00535	COG1105	Belongs to the carbohydrate kinase PfkB family
K09K1_RS00540	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K09K1_RS00540	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K09K1_RS00540	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
K09K1_RS00570	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K09K1_RS00580	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K09K1_RS00585	COG0509	glycine decarboxylation via glycine cleavage system
K09K1_RS00595	COG0346	lactoylglutathione lyase activity
K09K1_RS00600	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K09K1_RS00605	COG0583	DNA-binding transcription factor activity
K09K1_RS00610	COG0697	spore germination
K09K1_RS00615	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K09K1_RS00645	COG2176	DNA-directed DNA polymerase activity
K09K1_RS00685	COG0242	peptide deformylase activity
K09K1_RS00720	COG2239	Acts as a magnesium transporter
K09K1_RS00740	COG0346	lactoylglutathione lyase activity
K09K1_RS00745	COG1902	pentaerythritol trinitrate reductase activity
K09K1_RS00755	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K09K1_RS00755	COG2755	lipolytic protein G-D-S-L family
K09K1_RS00765	COG5642	Protein of unknown function (DUF2384)
K09K1_RS00770	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
K09K1_RS00805	COG2076	Multidrug Resistance protein
K09K1_RS00825	COG2962	Rard protein
K09K1_RS00840	COG0835	chemotaxis
K09K1_RS00840	COG0784	Response regulator, receiver
K09K1_RS00850	COG2197	response regulator
K09K1_RS00860	COG3706	GGDEF domain
K09K1_RS00865	COG2197	response regulator
K09K1_RS00870	COG5001	Diguanylate cyclase
K09K1_RS00870	COG3300	MHYT domain
K09K1_RS00875	COG0784	Response regulator, receiver
K09K1_RS00875	COG2205	protein histidine kinase activity
K09K1_RS00880	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
K09K1_RS00900	COG1214	PFAM Peptidase M22, glycoprotease
K09K1_RS00900	COG0456	acetyltransferase
K09K1_RS00910	COG3069	C4-dicarboxylate transmembrane transporter activity
K09K1_RS00940	COG3111	PFAM Bacterial OB fold (BOF) protein
K09K1_RS00945	COG1597	lipid kinase activity
K09K1_RS00950	COG0583	DNA-binding transcription factor activity
K09K1_RS00955	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K09K1_RS00985	COG0714	Associated with various cellular activities
K09K1_RS00990	COG0641	radical SAM
K09K1_RS00995	COG3119	arylsulfatase activity
K09K1_RS01005	COG3119	arylsulfatase activity
K09K1_RS01010	COG0745	RESPONSE REGULATOR receiver
K09K1_RS01025	COG2198	Histidine kinase
K09K1_RS01025	COG0784	Response regulator, receiver
K09K1_RS01025	COG2205	protein histidine kinase activity
K09K1_RS01030	COG1879	ABC-type sugar transport system periplasmic component
K09K1_RS01035	COG1803	Methylglyoxal synthase
K09K1_RS01040	COG0210	DNA helicase
K09K1_RS01045	COG1289	transmembrane transporter activity
K09K1_RS01080	COG4771	TonB-dependent receptor
K09K1_RS01080	COG1629	transport
K09K1_RS01090	COG0789	Transcriptional regulator
K09K1_RS01095	COG4604	ABC transporter, ATP-binding protein
K09K1_RS01100	COG4605	iron ion homeostasis
K09K1_RS01105	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K09K1_RS01110	COG4607	ABC-type enterochelin transport system periplasmic component
K09K1_RS01120	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
K09K1_RS01135	COG1609	Transcriptional regulator
K09K1_RS01140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K09K1_RS01145	COG1879	ABC-type sugar transport system periplasmic component
K09K1_RS01150	COG1172	Belongs to the binding-protein-dependent transport system permease family
K09K1_RS01155	COG1129	ABC transporter
K09K1_RS01160	COG1869	D-ribose catabolic process
K09K1_RS01165	COG5001	Diguanylate cyclase
K09K1_RS01220	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K09K1_RS01230	COG0784	Response regulator, receiver
K09K1_RS01230	COG2205	protein histidine kinase activity
K09K1_RS01245	COG0330	HflC and HflK could
K09K1_RS01260	COG4175	Glycine betaine
K09K1_RS01260	COG0517	IMP dehydrogenase activity
K09K1_RS01265	COG4176	ABC-type proline glycine betaine transport system permease component
K09K1_RS01280	COG1012	belongs to the aldehyde dehydrogenase family
K09K1_RS01285	COG1309	transcriptional regulator
K09K1_RS01295	COG1028	Short-chain dehydrogenase reductase Sdr
K09K1_RS01310	COG1024	Enoyl-CoA hydratase
K09K1_RS01315	COG1960	acyl-CoA dehydrogenase activity
K09K1_RS01325	COG0183	Belongs to the thiolase family
K09K1_RS01335	COG1960	acyl-CoA dehydrogenase activity
K09K1_RS01340	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K09K1_RS01350	COG4770	biotin carboxylase activity
K09K1_RS01365	COG3264	Mechanosensitive ion channel
K09K1_RS01365	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K09K1_RS01370	COG0110	maltose O-acetyltransferase activity
K09K1_RS01375	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K09K1_RS01380	COG1271	oxidase subunit
K09K1_RS01385	COG1294	oxidase, subunit
K09K1_RS01395	COG0384	phenazine biosynthesis protein PhzF
K09K1_RS01415	COG3527	Alpha-acetolactate decarboxylase
K09K1_RS01425	COG1028	Short-chain dehydrogenase reductase Sdr
K09K1_RS01430	COG0500	methyltransferase
K09K1_RS01460	COG1022	Amp-dependent synthetase and ligase
K09K1_RS01490	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K09K1_RS01495	COG1263	PTS System
K09K1_RS01495	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K09K1_RS01500	COG1486	melibiose metabolic process
K09K1_RS01505	COG2188	Transcriptional regulator
K09K1_RS01510	COG1320	monovalent cation:proton antiporter activity
K09K1_RS01515	COG2212	antiporter activity
K09K1_RS01520	COG1863	multisubunit Na H antiporter MnhE subunit
K09K1_RS01525	COG0651	ATP synthesis coupled electron transport
K09K1_RS01530	COG1006	Multisubunit Na H antiporter MnhC subunit
K09K1_RS01535	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K09K1_RS01535	COG2111	Na H antiporter
K09K1_RS01545	COG0589	response to stress
K09K1_RS01550	COG4221	oxidoreductase activity
K09K1_RS01555	COG0583	DNA-binding transcription factor activity
K09K1_RS01565	COG2814	Major facilitator Superfamily
K09K1_RS01630	COG1522	sequence-specific DNA binding
K09K1_RS01665	COG0515	serine threonine protein kinase
K09K1_RS01690	COG3501	Rhs element vgr protein
K09K1_RS01705	COG2204	response regulator
K09K1_RS01730	COG0739	heme binding
K09K1_RS01745	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K09K1_RS01795	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
K09K1_RS01805	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
K09K1_RS01805	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
K09K1_RS01820	COG4989	oxidoreductase activity
K09K1_RS01835	COG0038	chloride channel
K09K1_RS01870	COG2897	thiosulfate sulfurtransferase activity
K09K1_RS01890	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K09K1_RS01895	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K09K1_RS01900	COG0840	transmembrane signaling receptor activity
K09K1_RS01905	COG2814	Major facilitator Superfamily
K09K1_RS01910	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K09K1_RS01925	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K09K1_RS01935	COG0840	transmembrane signaling receptor activity
K09K1_RS01955	COG2195	Cleaves the N-terminal amino acid of tripeptides
K09K1_RS01970	COG2197	response regulator
K09K1_RS01975	COG3850	Histidine kinase
K09K1_RS01980	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K09K1_RS01990	COG0243	molybdopterin cofactor binding
K09K1_RS02000	COG3005	denitrification pathway
K09K1_RS02010	COG3243	poly(R)-hydroxyalkanoic acid synthase
K09K1_RS02020	COG0183	Belongs to the thiolase family
K09K1_RS02030	COG1280	lysine exporter protein (LysE YggA)
K09K1_RS02040	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K09K1_RS02045	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K09K1_RS02100	COG1846	Transcriptional regulator
K09K1_RS02105	COG0784	Response regulator, receiver
K09K1_RS02105	COG2205	protein histidine kinase activity
K09K1_RS02110	COG1879	ABC-type sugar transport system periplasmic component
K09K1_RS02120	COG2827	Endonuclease containing a URI domain
K09K1_RS02125	COG3132	Protein of unknown function, DUF480
K09K1_RS02145	COG2205	protein histidine kinase activity
K09K1_RS02145	COG5002	protein histidine kinase activity
K09K1_RS02145	COG0784	Response regulator, receiver
K09K1_RS02170	COG0583	DNA-binding transcription factor activity
K09K1_RS02180	COG0531	amino acid
K09K1_RS02195	COG2205	protein histidine kinase activity
K09K1_RS02200	COG0745	RESPONSE REGULATOR receiver
K09K1_RS02230	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K09K1_RS02235	COG2239	Acts as a magnesium transporter
K09K1_RS02240	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
K09K1_RS02245	COG0402	S-adenosylhomocysteine deaminase activity
K09K1_RS02250	COG1418	mRNA catabolic process
K09K1_RS02260	COG2814	Major facilitator Superfamily
K09K1_RS02270	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K09K1_RS02290	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K09K1_RS02305	COG0745	RESPONSE REGULATOR receiver
K09K1_RS02310	COG2205	protein histidine kinase activity
K09K1_RS02320	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K09K1_RS02325	COG2194	sulfuric ester hydrolase activity
K09K1_RS02345	COG4667	esterase of the alpha-beta hydrolase superfamily
K09K1_RS02350	COG1741	Belongs to the pirin family
K09K1_RS02355	COG1278	Cold shock
K09K1_RS02370	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K09K1_RS02375	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K09K1_RS02375	COG0678	peroxiredoxin activity
K09K1_RS02385	COG1686	Belongs to the peptidase S11 family
K09K1_RS02395	COG0625	glutathione transferase activity
K09K1_RS02405	COG1621	beta-fructofuranosidase activity
K09K1_RS02410	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K09K1_RS02415	COG1263	PTS System
K09K1_RS02415	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K09K1_RS02435	COG1028	Short-chain dehydrogenase reductase Sdr
K09K1_RS02450	COG3746	phosphate-selective porin O and P
K09K1_RS02465	COG0300	oxidoreductase activity
K09K1_RS02470	COG0583	DNA-binding transcription factor activity
K09K1_RS02475	COG2207	Transcriptional regulator
K09K1_RS02475	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K09K1_RS02480	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K09K1_RS02505	COG0513	Belongs to the DEAD box helicase family
K09K1_RS02515	COG0583	DNA-binding transcription factor activity
K09K1_RS02530	COG1902	pentaerythritol trinitrate reductase activity
K09K1_RS02535	COG1063	alcohol dehydrogenase
K09K1_RS02545	COG1028	Short-chain dehydrogenase reductase Sdr
K09K1_RS02555	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K09K1_RS02560	COG0006	proline dipeptidase activity
K09K1_RS02565	COG3608	succinylglutamate desuccinylase aspartoacylase
K09K1_RS02570	COG1522	sequence-specific DNA binding
K09K1_RS02575	COG1012	belongs to the aldehyde dehydrogenase family
K09K1_RS02580	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K09K1_RS02585	COG3122	Protein conserved in bacteria
K09K1_RS02600	COG0583	DNA-binding transcription factor activity
K09K1_RS02605	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K09K1_RS02610	COG0252	asparaginase activity
K09K1_RS02615	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
K09K1_RS02630	COG2197	response regulator
K09K1_RS02635	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K09K1_RS02660	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K09K1_RS02690	COG3842	ATPase activity
K09K1_RS02710	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K09K1_RS02740	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K09K1_RS02745	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K09K1_RS02780	COG0583	DNA-binding transcription factor activity
K09K1_RS02790	COG4948	Mandelate Racemase Muconate Lactonizing
K09K1_RS02825	COG1342	Belongs to the UPF0251 family
K09K1_RS02830	COG4176	ABC-type proline glycine betaine transport system permease component
K09K1_RS02835	COG4175	Glycine betaine
K09K1_RS02835	COG3448	diguanylate cyclase activity
K09K1_RS02840	COG3015	lipoprotein NlpE involved in copper resistance
K09K1_RS02845	COG3713	MltA-interacting MipA family protein
K09K1_RS02860	COG0583	DNA-binding transcription factor activity
K09K1_RS02885	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
K09K1_RS02895	COG1335	isochorismatase
K09K1_RS02910	COG1349	DNA-binding transcription factor activity
K09K1_RS02920	COG2070	2-Nitropropane dioxygenase
K09K1_RS02925	COG0531	amino acid
K09K1_RS02930	COG4302	ethanolamine ammonia-lyase activity
K09K1_RS02935	COG4303	Ethanolamine ammonia lyase large subunit
K09K1_RS02945	COG1309	transcriptional regulator
K09K1_RS02965	COG1280	lysine exporter protein (LysE YggA)
K09K1_RS02975	COG0459	protein refolding
K09K1_RS02980	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
K09K1_RS02990	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K09K1_RS03005	COG1304	FMN binding
K09K1_RS03030	COG4786	Flagellar basal body rod
K09K1_RS03030	COG1256	bacterial-type flagellum assembly
K09K1_RS03040	COG1706	bacterial-type flagellum-dependent cell motility
K09K1_RS03045	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
K09K1_RS03050	COG4786	Flagellar basal body rod
K09K1_RS03055	COG4787	bacterial-type flagellum-dependent cell motility
K09K1_RS03070	COG1558	bacterial-type flagellum-dependent cell motility
K09K1_RS03075	COG1815	bacterial-type flagellum-dependent cell motility
K09K1_RS03095	COG0741	lytic transglycosylase activity
K09K1_RS03100	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K09K1_RS03120	COG1760	l-serine dehydratase
K09K1_RS03135	COG0583	DNA-binding transcription factor activity
K09K1_RS03145	COG2866	Carboxypeptidase
K09K1_RS03150	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K09K1_RS03160	COG2990	Protein conserved in bacteria
K09K1_RS03185	COG3842	ATPase activity
K09K1_RS03195	COG1840	ABC-type Fe3 transport system, periplasmic component
K09K1_RS03205	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K09K1_RS03215	COG1609	Transcriptional regulator
K09K1_RS03245	COG3240	lipase activity
K09K1_RS03250	COG1309	transcriptional regulator
K09K1_RS03265	COG0577	efflux transmembrane transporter activity
K09K1_RS03265	COG1136	(ABC) transporter
K09K1_RS03270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K09K1_RS03275	COG2067	long-chain fatty acid transport protein
K09K1_RS03285	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
K09K1_RS03300	COG1011	Hydrolase
K09K1_RS03340	COG0110	maltose O-acetyltransferase activity
K09K1_RS03345	COG1765	OsmC-like protein
K09K1_RS03350	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K09K1_RS03350	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K09K1_RS03365	COG3046	protein related to deoxyribodipyrimidine photolyase
K09K1_RS03370	COG0415	Belongs to the DNA photolyase family
K09K1_RS03375	COG3706	GGDEF domain
K09K1_RS03390	COG3706	GGDEF domain
K09K1_RS03405	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K09K1_RS03425	COG3033	Beta-eliminating lyase
K09K1_RS03435	COG1271	oxidase subunit
K09K1_RS03440	COG1294	oxidase, subunit
K09K1_RS03460	COG3179	chitinase
K09K1_RS03465	COG0579	oxidoreductase
K09K1_RS03485	COG3706	GGDEF domain
K09K1_RS03520	COG0583	DNA-binding transcription factor activity
K09K1_RS03545	COG0189	ligase activity
K09K1_RS03550	COG0189	ligase activity
K09K1_RS03550	COG4067	protein conserved in archaea
K09K1_RS03560	COG1166	arginine decarboxylase activity
K09K1_RS03565	COG0010	Belongs to the arginase family
K09K1_RS03570	COG2814	Major facilitator Superfamily
K09K1_RS03575	COG1770	oligopeptidase
K09K1_RS03590	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K09K1_RS03595	COG1121	(ABC) transporter
K09K1_RS03600	COG0803	Belongs to the bacterial solute-binding protein 9 family
K09K1_RS03640	COG0848	biopolymer transport protein
K09K1_RS03645	COG0811	peptide transport
K09K1_RS03650	COG0811	peptide transport
K09K1_RS03670	COG0745	RESPONSE REGULATOR receiver
K09K1_RS03675	COG0584	glycerophosphoryl diester phosphodiesterase
K09K1_RS03685	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K09K1_RS03750	COG0312	modulator of DNA gyrase
K09K1_RS03755	COG0312	modulator of DNA gyrase
K09K1_RS03760	COG0351	phosphomethylpyrimidine kinase
K09K1_RS03765	COG1116	anion transmembrane transporter activity
K09K1_RS03770	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K09K1_RS03775	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K09K1_RS03780	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
K09K1_RS03800	COG0243	molybdopterin cofactor binding
K09K1_RS03805	COG3005	denitrification pathway
K09K1_RS03810	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K09K1_RS03815	COG1028	Short-chain dehydrogenase reductase Sdr
K09K1_RS03830	COG0456	acetyltransferase
K09K1_RS03850	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K09K1_RS03855	COG1929	Belongs to the glycerate kinase type-1 family
K09K1_RS03860	COG2610	gluconate transmembrane transporter activity
K09K1_RS03865	COG3835	regulator
K09K1_RS03925	COG3047	cAMP biosynthetic process
K09K1_RS03930	COG1357	PFAM Pentapeptide repeats (8 copies)
K09K1_RS03960	COG2375	cellular response to nickel ion
K09K1_RS03965	COG0583	DNA-binding transcription factor activity
K09K1_RS03970	COG2162	N-hydroxyarylamine O-acetyltransferase activity
K09K1_RS03975	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
K09K1_RS03990	COG2199	diguanylate cyclase activity
K09K1_RS04000	COG0561	phosphatase activity
K09K1_RS04005	COG0583	DNA-binding transcription factor activity
K09K1_RS04020	COG0564	pseudouridine synthase activity
K09K1_RS04025	COG0534	Mate efflux family protein
K09K1_RS04040	COG3123	guanosine phosphorylase activity
K09K1_RS04055	COG0596	Alpha beta hydrolase
K09K1_RS04080	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K09K1_RS04090	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K09K1_RS04095	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K09K1_RS04095	COG2169	Transcriptional regulator
K09K1_RS04105	COG2259	Doxx family
K09K1_RS04110	COG1741	Belongs to the pirin family
K09K1_RS04130	COG0363	glucosamine-6-phosphate deaminase activity
K09K1_RS04140	COG0786	glutamate:sodium symporter activity
K09K1_RS04145	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K09K1_RS04150	COG1131	(ABC) transporter
K09K1_RS04160	COG0786	glutamate:sodium symporter activity
K09K1_RS04185	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K09K1_RS04195	COG3279	Response regulator of the LytR AlgR family
K09K1_RS04200	COG3275	phosphorelay sensor kinase activity
K09K1_RS04230	COG0772	Belongs to the SEDS family
K09K1_RS04255	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
K09K1_RS04255	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K09K1_RS04265	COG0444	Belongs to the ABC transporter superfamily
K09K1_RS04270	COG4608	Belongs to the ABC transporter superfamily
K09K1_RS04295	COG1444	tRNA N-acetyltransferase activity
K09K1_RS04315	COG3340	Belongs to the peptidase S51 family
K09K1_RS04320	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K09K1_RS04325	COG1263	PTS System
K09K1_RS04325	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K09K1_RS04330	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
K09K1_RS04345	COG4166	transmembrane transport
K09K1_RS04390	COG0259	pyridoxamine-phosphate oxidase activity
K09K1_RS04415	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K09K1_RS04455	COG1132	(ABC) transporter
K09K1_RS04465	COG0513	Belongs to the DEAD box helicase family
K09K1_RS04470	COG2258	MOSC domain
K09K1_RS04525	COG3634	alkyl hydroperoxide reductase activity
K09K1_RS04570	COG1846	Transcriptional regulator
K09K1_RS04575	COG1764	response to oxidative stress
K09K1_RS04610	COG0577	efflux transmembrane transporter activity
K09K1_RS04615	COG1136	(ABC) transporter
K09K1_RS04630	COG0826	peptidase U32
K09K1_RS04655	COG1653	transport
K09K1_RS04660	COG0019	diaminopimelate decarboxylase activity
K09K1_RS04665	COG4264	IucA IucC family
K09K1_RS04690	COG4772	TonB-dependent receptor
K09K1_RS04695	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
K09K1_RS04700	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K09K1_RS04705	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K09K1_RS04710	COG1120	ATPase activity
K09K1_RS04715	COG0840	transmembrane signaling receptor activity
K09K1_RS04720	COG0612	Peptidase, M16
K09K1_RS04730	COG0739	heme binding
K09K1_RS04745	COG2814	Major facilitator Superfamily
K09K1_RS04755	COG1609	Transcriptional regulator
K09K1_RS04760	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K09K1_RS04780	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K09K1_RS04780	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K09K1_RS04790	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K09K1_RS04795	COG1609	Transcriptional regulator
K09K1_RS04805	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K09K1_RS04820	COG0596	Alpha beta hydrolase
K09K1_RS04845	COG1760	l-serine dehydratase
K09K1_RS04855	COG4580	involved in the transport of maltose and maltodextrins
K09K1_RS04875	COG2356	endonuclease I
K09K1_RS04895	COG1982	Orn Lys Arg decarboxylase major
K09K1_RS04900	COG0531	amino acid
K09K1_RS04910	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
K09K1_RS04915	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
K09K1_RS04920	COG1162	GTPase activity
K09K1_RS04925	COG1263	PTS System
K09K1_RS04925	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K09K1_RS04930	COG1999	signal sequence binding
K09K1_RS04945	COG2909	trisaccharide binding
K09K1_RS04955	COG0058	SHG alpha-glucan phosphorylase activity
K09K1_RS04960	COG1640	4-alpha-glucanotransferase
K09K1_RS04965	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
K09K1_RS04970	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K09K1_RS04975	COG0366	Alpha amylase catalytic
K09K1_RS04990	COG3366	ferrous iron transmembrane transporter activity
K09K1_RS04995	COG0700	Nucleoside recognition
K09K1_RS05000	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K09K1_RS05005	COG3339	Conserved Protein
K09K1_RS05010	COG1301	dicarboxylic acid transport
K09K1_RS05020	COG0583	DNA-binding transcription factor activity
K09K1_RS05040	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K09K1_RS05045	COG1596	polysaccharide export
K09K1_RS05060	COG2095	MarC family integral membrane protein
K09K1_RS05065	COG4667	esterase of the alpha-beta hydrolase superfamily
K09K1_RS05070	COG3397	chitin binding
K09K1_RS05075	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
K09K1_RS05080	COG0415	Belongs to the DNA photolyase family
K09K1_RS05090	COG1054	Belongs to the UPF0176 family
K09K1_RS05100	COG1686	Belongs to the peptidase S11 family
K09K1_RS05125	COG0583	DNA-binding transcription factor activity
K09K1_RS05130	COG4628	conserved protein (DUF2132)
K09K1_RS05150	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
K09K1_RS05155	COG0628	permease
K09K1_RS05180	COG1289	transmembrane transporter activity
K09K1_RS05200	COG2814	Major facilitator Superfamily
K09K1_RS05210	COG0454	-acetyltransferase
K09K1_RS05220	COG0745	RESPONSE REGULATOR receiver
K09K1_RS05225	COG2205	protein histidine kinase activity
K09K1_RS05240	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K09K1_RS05245	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K09K1_RS05250	COG1882	Formate acetyltransferase
K09K1_RS05285	COG1360	Flagellar Motor Protein
K09K1_RS05290	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K09K1_RS05295	COG1191	sigma factor activity
K09K1_RS05300	COG1580	Controls the rotational direction of flagella during chemotaxis
K09K1_RS05315	COG1516	flagellar protein fliS
K09K1_RS05320	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
K09K1_RS05330	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K09K1_RS05345	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K09K1_RS05355	COG1987	bacterial-type flagellum assembly
K09K1_RS05395	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K09K1_RS05455	COG0346	lactoylglutathione lyase activity
K09K1_RS05480	COG0745	RESPONSE REGULATOR receiver
K09K1_RS05505	COG5001	Diguanylate cyclase
K09K1_RS05505	COG3300	MHYT domain
K09K1_RS05510	COG0156	8-amino-7-oxononanoate synthase activity
K09K1_RS05515	COG1063	alcohol dehydrogenase
K09K1_RS05550	COG0668	transmembrane transport
K09K1_RS05560	COG1304	FMN binding
K09K1_RS05565	COG1620	l-lactate permease
K09K1_RS05570	COG0583	DNA-binding transcription factor activity
K09K1_RS05575	COG1505	serine-type exopeptidase activity
K09K1_RS05580	COG4172	Belongs to the ABC transporter superfamily
K09K1_RS05590	COG1067	ATP-dependent peptidase activity
K09K1_RS05600	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K09K1_RS05620	COG1247	-acetyltransferase
K09K1_RS05625	COG0437	4 iron, 4 sulfur cluster binding
K09K1_RS05630	COG0348	domain, Protein
K09K1_RS05650	COG1122	ATPase activity
K09K1_RS05655	COG4720	Psort location CytoplasmicMembrane, score
K09K1_RS05660	COG1566	PFAM secretion protein HlyD family protein
K09K1_RS05685	COG0813	purine-nucleoside phosphorylase activity
K09K1_RS05690	COG3272	Protein of unknown function (DUF1722)
K09K1_RS05695	COG0789	Transcriptional regulator
K09K1_RS05700	COG0415	Belongs to the DNA photolyase family
K09K1_RS05705	COG1388	LysM domain
K09K1_RS05705	COG1376	ErfK ybiS ycfS ynhG family protein
K09K1_RS05715	COG0513	Belongs to the DEAD box helicase family
K09K1_RS05720	COG1770	oligopeptidase
K09K1_RS05725	COG4771	TonB-dependent receptor
K09K1_RS05755	COG0573	inorganic phosphate transmembrane transporter activity
K09K1_RS05760	COG0581	inorganic phosphate transmembrane transporter activity
K09K1_RS05765	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K09K1_RS05780	COG2304	oxidoreductase activity
K09K1_RS05800	COG0714	Associated with various cellular activities
K09K1_RS05815	COG2197	response regulator
K09K1_RS05850	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
K09K1_RS05855	COG1120	ATPase activity
K09K1_RS05860	COG4774	siderophore transport
K09K1_RS05865	COG1132	(ABC) transporter
K09K1_RS05870	COG2205	protein histidine kinase activity
K09K1_RS05880	COG0569	domain protein
K09K1_RS05885	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K09K1_RS05890	COG0583	DNA-binding transcription factor activity
K09K1_RS05905	COG1012	belongs to the aldehyde dehydrogenase family
K09K1_RS05910	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K09K1_RS05915	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K09K1_RS05925	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
K09K1_RS05930	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K09K1_RS05960	COG2084	Dehydrogenase
K09K1_RS05965	COG0753	catalase activity
K09K1_RS05975	COG2130	NADP-dependent
K09K1_RS05980	COG1309	transcriptional regulator
K09K1_RS05985	COG3097	Belongs to the UPF0267 family
K09K1_RS06025	COG0489	protein tyrosine kinase activity
K09K1_RS06025	COG3206	protein involved in exopolysaccharide biosynthesis
K09K1_RS06040	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K09K1_RS06045	COG3842	ATPase activity
K09K1_RS06055	COG1175	transmembrane transport
K09K1_RS06060	COG3833	ABC-type maltose transport systems, permease component
K09K1_RS06090	COG2354	Protein conserved in bacteria
K09K1_RS06095	COG0418	dihydroorotase activity
K09K1_RS06105	COG0401	homolog of Blt101
K09K1_RS06110	COG0633	Ferredoxin
K09K1_RS06110	COG3217	Mosc domain protein beta barrel domain protein
K09K1_RS06110	COG0633	Ferredoxin
K09K1_RS06110	COG3217	Mosc domain protein beta barrel domain protein
K09K1_RS06120	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K09K1_RS06160	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
K09K1_RS06165	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K09K1_RS06175	COG0848	biopolymer transport protein
K09K1_RS06180	COG0811	peptide transport
K09K1_RS06185	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
K09K1_RS06195	COG3721	Heme iron utilization protein
K09K1_RS06200	COG0748	coenzyme F420 binding
K09K1_RS06210	COG0835	chemotaxis
K09K1_RS06210	COG0784	Response regulator, receiver
K09K1_RS06215	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K09K1_RS06220	COG0534	Mate efflux family protein
K09K1_RS06225	COG0444	Belongs to the ABC transporter superfamily
K09K1_RS06230	COG4608	Belongs to the ABC transporter superfamily
K09K1_RS06235	COG0747	negative chemotaxis
K09K1_RS06245	COG1349	DNA-binding transcription factor activity
K09K1_RS06250	COG2084	Dehydrogenase
K09K1_RS06255	COG3395	kinase activity
K09K1_RS06260	COG0235	Class ii aldolase
K09K1_RS06265	COG3622	Belongs to the hyi family
K09K1_RS06270	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K09K1_RS06275	COG2610	gluconate transmembrane transporter activity
K09K1_RS06295	COG0583	DNA-binding transcription factor activity
K09K1_RS06300	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K09K1_RS06310	COG4934	collagen metabolic process
K09K1_RS06320	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K09K1_RS06325	COG0789	Transcriptional regulator
K09K1_RS06330	COG0366	Alpha amylase catalytic
K09K1_RS06350	COG2249	NAD(P)H dehydrogenase (quinone) activity
K09K1_RS06355	COG0589	response to stress
K09K1_RS06360	COG0488	(ABC) transporter
K09K1_RS06365	COG1505	serine-type exopeptidase activity
K09K1_RS06375	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K09K1_RS06385	COG2067	long-chain fatty acid transport protein
K09K1_RS06395	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K09K1_RS06420	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K09K1_RS06440	COG3383	formate dehydrogenase (NAD+) activity
K09K1_RS06450	COG0842	Transport permease protein
K09K1_RS06455	COG1131	(ABC) transporter
K09K1_RS06475	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
K09K1_RS06485	COG4145	pantothenate transmembrane transporter activity
K09K1_RS06490	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K09K1_RS06495	COG0800	Aldolase
K09K1_RS06505	COG2706	6-phosphogluconolactonase activity
K09K1_RS06510	COG0251	oxidation-reduction process
K09K1_RS06520	COG1881	PFAM PEBP family protein
K09K1_RS06530	COG0798	PFAM Bile acid sodium symporter
K09K1_RS06545	COG1733	regulation of RNA biosynthetic process
K09K1_RS06570	COG4989	oxidoreductase activity
K09K1_RS06595	COG0814	amino acid
K09K1_RS06610	COG3314	Sporulation integral membrane protein YlbJ
K09K1_RS06630	COG0739	heme binding
K09K1_RS06635	COG5001	Diguanylate cyclase
K09K1_RS06640	COG0583	DNA-binding transcription factor activity
K09K1_RS06645	COG2814	Major facilitator Superfamily
K09K1_RS06665	COG0697	spore germination
K09K1_RS06670	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K09K1_RS06680	COG0179	Fumarylacetoacetate (FAA) hydrolase
K09K1_RS06700	COG1280	lysine exporter protein (LysE YggA)
K09K1_RS06710	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K09K1_RS06715	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K09K1_RS06720	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K09K1_RS06725	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
K09K1_RS06750	COG1612	heme a metabolic process
K09K1_RS06755	COG0109	protoheme IX farnesyltransferase activity
K09K1_RS06760	COG0545	Peptidyl-prolyl cis-trans isomerase
K09K1_RS06790	COG1278	Cold shock
K09K1_RS06795	COG3036	rescue of stalled ribosome
K09K1_RS06800	COG2199	diguanylate cyclase activity
K09K1_RS06815	COG1132	(ABC) transporter
K09K1_RS06820	COG1132	(ABC) transporter
K09K1_RS06825	COG1538	Outer membrane efflux protein
K09K1_RS06830	COG0784	Response regulator, receiver
K09K1_RS06830	COG2205	protein histidine kinase activity
K09K1_RS06855	COG0840	transmembrane signaling receptor activity
K09K1_RS06860	COG0783	Belongs to the Dps family
K09K1_RS06870	COG2133	pyrroloquinoline quinone binding
K09K1_RS06875	COG1454	alcohol dehydrogenase
K09K1_RS06880	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
K09K1_RS06900	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K09K1_RS06905	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K09K1_RS06910	COG3186	Phenylalanine-4-hydroxylase
K09K1_RS06935	COG3530	Putative quorum-sensing-regulated virulence factor
K09K1_RS06955	COG0513	Belongs to the DEAD box helicase family
K09K1_RS06960	COG4628	conserved protein (DUF2132)
K09K1_RS06970	COG0133	tryptophan synthase activity
K09K1_RS06980	COG1278	Cold shock
K09K1_RS06990	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
K09K1_RS07000	COG0523	cobalamin synthesis protein
K09K1_RS07005	COG0513	Belongs to the DEAD box helicase family
K09K1_RS07025	COG2200	EAL domain
K09K1_RS07030	COG1119	ATPase activity
K09K1_RS07065	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
K09K1_RS07070	COG0513	Belongs to the DEAD box helicase family
K09K1_RS07085	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K09K1_RS07095	COG1073	alpha beta
K09K1_RS07100	COG1073	alpha beta
K09K1_RS07115	COG0730	response to heat
K09K1_RS07135	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K09K1_RS07145	COG0523	cobalamin synthesis protein
K09K1_RS07150	COG2988	succinylglutamate desuccinylase activity
K09K1_RS07155	COG0739	heme binding
K09K1_RS07165	COG0523	cobalamin synthesis protein
K09K1_RS07185	COG2095	MarC family integral membrane protein
K09K1_RS07210	COG1024	Enoyl-CoA hydratase
K09K1_RS07215	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K09K1_RS07220	COG1960	acyl-CoA dehydrogenase activity
K09K1_RS07230	COG0183	Belongs to the thiolase family
K09K1_RS07245	COG1024	Enoyl-CoA hydratase
K09K1_RS07250	COG1024	Enoyl-CoA hydratase
K09K1_RS07260	COG1028	Short-chain dehydrogenase reductase Sdr
K09K1_RS07265	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K09K1_RS07270	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K09K1_RS07275	COG1845	cytochrome c oxidase, subunit III
K09K1_RS07280	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
K09K1_RS07285	COG0109	protoheme IX farnesyltransferase activity
K09K1_RS07290	COG0446	pyridine nucleotide-disulphide oxidoreductase
K09K1_RS07290	COG1902	pentaerythritol trinitrate reductase activity
K09K1_RS07305	COG1012	belongs to the aldehyde dehydrogenase family
K09K1_RS07315	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K09K1_RS07345	COG1126	abc transporter atp-binding protein
K09K1_RS07350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K09K1_RS07355	COG4215	(ABC) transporter
K09K1_RS07360	COG4160	amino acid transport
K09K1_RS07425	COG0443	Heat shock 70 kDa protein
K09K1_RS07430	COG2847	Copper chaperone PCu(A)C
K09K1_RS07495	COG0814	amino acid
K09K1_RS07505	COG0243	molybdopterin cofactor binding
K09K1_RS07535	COG1116	anion transmembrane transporter activity
K09K1_RS07535	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K09K1_RS07540	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K09K1_RS07545	COG1116	anion transmembrane transporter activity
K09K1_RS07550	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K09K1_RS07550	COG2146	nitrite reductase [NAD(P)H] activity
K09K1_RS07605	COG2815	serine threonine protein kinase
K09K1_RS07605	COG0515	serine threonine protein kinase
K09K1_RS07640	COG0631	protein serine/threonine phosphatase activity
K09K1_RS07710	COG0420	3'-5' exonuclease activity
K09K1_RS07715	COG0419	ATPase involved in DNA repair
K09K1_RS07725	COG3040	lipid binding
K09K1_RS07735	COG1288	antiporter activity
K09K1_RS07745	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
K09K1_RS07760	COG2425	protein containing a von Willebrand factor type A (vWA) domain
K09K1_RS07775	COG0583	DNA-binding transcription factor activity
K09K1_RS07780	COG0277	FAD linked oxidase domain protein
K09K1_RS07795	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K09K1_RS07830	COG2176	DNA-directed DNA polymerase activity
K09K1_RS07875	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
K09K1_RS07880	COG1328	CTP reductase activity
K09K1_RS08080	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K09K1_RS08105	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K09K1_RS08110	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K09K1_RS08120	COG2116	formate transmembrane transporter activity
K09K1_RS08140	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
K09K1_RS08180	COG3118	belongs to the thioredoxin family
K09K1_RS08185	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K09K1_RS08210	COG2271	Major facilitator Superfamily
K09K1_RS08215	COG3851	Histidine kinase
K09K1_RS08220	COG2197	response regulator
K09K1_RS08230	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K09K1_RS08235	COG0583	DNA-binding transcription factor activity
K09K1_RS08245	COG0243	molybdopterin cofactor binding
K09K1_RS08260	COG0384	phenazine biosynthesis protein PhzF
K09K1_RS08265	COG1794	racemase activity, acting on amino acids and derivatives
K09K1_RS08295	COG1328	CTP reductase activity
K09K1_RS08300	COG0602	queuosine metabolic process
K09K1_RS08305	COG0534	Mate efflux family protein
K09K1_RS08310	COG2207	Transcriptional regulator
K09K1_RS08320	COG0189	ligase activity
K09K1_RS08320	COG4067	protein conserved in archaea
K09K1_RS08330	COG3111	PFAM Bacterial OB fold (BOF) protein
K09K1_RS08340	COG0725	ABC transporter, periplasmic molybdate-binding protein
K09K1_RS08345	COG4149	molybdate abc transporter
K09K1_RS08350	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
K09K1_RS08360	COG3706	GGDEF domain
K09K1_RS08360	COG2203	Gaf domain
K09K1_RS08360	COG4251	negative regulation of phosphorylation
K09K1_RS08360	COG5001	Diguanylate cyclase
K09K1_RS08380	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
K09K1_RS08385	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
K09K1_RS08410	COG3140	Belongs to the UPF0181 family
K09K1_RS08425	COG0583	DNA-binding transcription factor activity
K09K1_RS08585	COG4128	Pfam Zonular occludens toxin
K09K1_RS08725	COG4128	Pfam Zonular occludens toxin
K09K1_RS08775	COG0784	Response regulator, receiver
K09K1_RS08775	COG2205	protein histidine kinase activity
K09K1_RS08790	COG3278	Belongs to the heme-copper respiratory oxidase family
K09K1_RS08805	COG2010	Cytochrome c
K09K1_RS08815	COG2217	Heavy metal translocating P-type atpase
K09K1_RS08830	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K09K1_RS08835	COG0589	response to stress
K09K1_RS08860	COG3842	ATPase activity
K09K1_RS08870	COG1177	transmembrane transport
K09K1_RS08880	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K09K1_RS08885	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K09K1_RS08890	COG0004	ammonium transporteR
K09K1_RS08915	COG0437	4 iron, 4 sulfur cluster binding
K09K1_RS08920	COG0243	molybdopterin cofactor binding
K09K1_RS08920	COG3383	formate dehydrogenase (NAD+) activity
K09K1_RS08930	COG3381	protein complex oligomerization
K09K1_RS08950	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K09K1_RS08955	COG0488	(ABC) transporter
K09K1_RS08960	COG4191	Histidine kinase
K09K1_RS08965	COG2204	response regulator
K09K1_RS08980	COG3842	ATPase activity
K09K1_RS08985	COG0746	molybdenum cofactor guanylyltransferase activity
K09K1_RS09000	COG1940	carbohydrate kinase activity
K09K1_RS09005	COG3148	PFAM DTW domain containing protein
K09K1_RS09040	COG0791	NLP P60 protein
K09K1_RS09050	COG3706	GGDEF domain
K09K1_RS09060	COG3001	Fructosamine kinase
K09K1_RS09070	COG0307	riboflavin synthase, alpha
K09K1_RS09075	COG0534	Mate efflux family protein
K09K1_RS09085	COG1793	dna ligase
K09K1_RS09120	COG2204	response regulator
K09K1_RS09125	COG0438	transferase activity, transferring glycosyl groups
K09K1_RS09130	COG0438	transferase activity, transferring glycosyl groups
K09K1_RS09160	COG0438	transferase activity, transferring glycosyl groups
K09K1_RS09165	COG1215	transferase activity, transferring glycosyl groups
K09K1_RS09170	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K09K1_RS09180	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K09K1_RS09195	COG1643	Atp-dependent helicase
K09K1_RS09200	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
K09K1_RS09245	COG0443	Heat shock 70 kDa protein
K09K1_RS09250	COG0443	Heat shock 70 kDa protein
K09K1_RS09275	COG0583	DNA-binding transcription factor activity
K09K1_RS09295	COG1132	(ABC) transporter
K09K1_RS09305	COG4774	siderophore transport
K09K1_RS09315	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K09K1_RS09320	COG1120	ATPase activity
K09K1_RS09335	COG0814	amino acid
K09K1_RS09345	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
K09K1_RS09355	COG0861	Integral membrane protein TerC family
K09K1_RS09365	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K09K1_RS09370	COG1328	CTP reductase activity
K09K1_RS09385	COG5001	Diguanylate cyclase
K09K1_RS09385	COG3300	MHYT domain
K09K1_RS09400	COG0471	metal ion transport
K09K1_RS09425	COG4702	Belongs to the UPF0303 family
K09K1_RS09430	COG0673	inositol 2-dehydrogenase activity
K09K1_RS09435	COG1349	DNA-binding transcription factor activity
K09K1_RS09450	COG1538	Outer membrane efflux protein
K09K1_RS09475	COG3119	arylsulfatase activity
K09K1_RS09490	COG0641	radical SAM
K09K1_RS09505	COG3119	arylsulfatase activity
K09K1_RS09510	COG0527	aspartate kinase activity
K09K1_RS09515	COG0662	Cupin 2, conserved barrel domain protein
K09K1_RS09520	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K09K1_RS09525	COG0456	acetyltransferase
K09K1_RS09530	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K09K1_RS09550	COG4176	ABC-type proline glycine betaine transport system permease component
K09K1_RS09555	COG2113	Glycine betaine
K09K1_RS09560	COG1368	sulfuric ester hydrolase activity
K09K1_RS09585	COG1115	amino acid carrier protein
K09K1_RS09595	COG1280	lysine exporter protein (LysE YggA)
K09K1_RS09600	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
K09K1_RS09725	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K09K1_RS09730	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
K09K1_RS09735	COG1560	Kdo2-lipid A biosynthetic process
K09K1_RS09750	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
K09K1_RS09755	COG3063	Type IV pilus biogenesis stability protein PilW
K09K1_RS09795	COG2315	Protein conserved in bacteria
K09K1_RS09800	COG1846	Transcriptional regulator
K09K1_RS09810	COG2200	EAL domain
K09K1_RS09815	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K09K1_RS09820	COG1012	belongs to the aldehyde dehydrogenase family
K09K1_RS09825	COG2957	Belongs to the agmatine deiminase family
K09K1_RS09835	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K09K1_RS09840	COG1012	belongs to the aldehyde dehydrogenase family
K09K1_RS09845	COG1917	Cupin 2, conserved barrel domain protein
K09K1_RS09845	COG1396	sequence-specific DNA binding
K09K1_RS09850	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
K09K1_RS09860	COG0174	glutamine synthetase
K09K1_RS09865	COG1757	Na H antiporter
K09K1_RS09880	COG1742	UPF0060 membrane protein
K09K1_RS09905	COG3755	Protein conserved in bacteria
K09K1_RS09955	COG0625	glutathione transferase activity
K09K1_RS09965	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
K09K1_RS09975	COG2195	Cleaves the N-terminal amino acid of tripeptides
K09K1_RS09985	COG0601	transmembrane transport
K09K1_RS10010	COG3291	Pkd domain containing protein
K09K1_RS10020	COG1177	transmembrane transport
K09K1_RS10025	COG1176	ABC-type spermidine putrescine transport system, permease component I
K09K1_RS10030	COG3842	ATPase activity
K09K1_RS10035	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K09K1_RS10040	COG2423	ornithine cyclodeaminase activity
K09K1_RS10055	COG3938	Belongs to the proline racemase family
K09K1_RS10085	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
K09K1_RS10090	COG1451	nucleotide metabolic process
K09K1_RS10100	COG0583	DNA-binding transcription factor activity
K09K1_RS10120	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
K09K1_RS10125	COG4139	cobalamin transport
K09K1_RS10130	COG2988	succinylglutamate desuccinylase activity
K09K1_RS10150	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
K09K1_RS10155	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
K09K1_RS10160	COG0702	epimerase
K09K1_RS10165	COG1823	symporter activity
K09K1_RS10310	COG1484	DNA-dependent DNA replication
K09K1_RS10335	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K09K1_RS10390	COG2925	Exonuclease
K09K1_RS10395	COG1380	Effector of murein hydrolase LrgA
K09K1_RS10400	COG1346	cytolysis
K09K1_RS10405	COG0295	cytidine deaminase activity
K09K1_RS10410	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
K09K1_RS10415	COG0500	methyltransferase
K09K1_RS10425	COG0776	regulation of translation
K09K1_RS10435	COG0072	phenylalanine-tRNA ligase activity
K09K1_RS10435	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K09K1_RS10440	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K09K1_RS10475	COG0393	Putative heavy-metal-binding
K09K1_RS10485	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K09K1_RS10495	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K09K1_RS10510	COG2188	Transcriptional regulator
K09K1_RS10515	COG1228	amidohydrolase
K09K1_RS10520	COG0010	Belongs to the arginase family
K09K1_RS10525	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
K09K1_RS10530	COG2986	histidine ammonia-lyase
K09K1_RS10545	COG0247	lactate metabolic process
K09K1_RS10545	COG0277	FAD linked oxidase domain protein
K09K1_RS10580	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K09K1_RS10595	COG1643	Atp-dependent helicase
K09K1_RS10600	COG0281	malic enzyme
K09K1_RS10605	COG2949	membrane
K09K1_RS10610	COG0471	metal ion transport
K09K1_RS10635	COG0492	ferredoxin-NADP+ reductase activity
K09K1_RS10640	COG4988	ABC transporter
K09K1_RS10645	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
K09K1_RS10655	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
K09K1_RS10665	COG4191	Histidine kinase
K09K1_RS10665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K09K1_RS10680	COG3070	regulator of competence-specific genes
K09K1_RS10700	COG2431	L-lysine efflux transmembrane transporter activity
K09K1_RS10710	COG0076	glutamate decarboxylase activity
K09K1_RS10715	COG1737	Transcriptional regulator
K09K1_RS10725	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K09K1_RS10730	COG2985	domain, Protein
K09K1_RS10730	COG3273	potassium ion transport
K09K1_RS10735	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K09K1_RS10740	COG1960	acyl-CoA dehydrogenase activity
K09K1_RS10755	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K09K1_RS10775	COG0534	Mate efflux family protein
K09K1_RS10780	COG0702	epimerase
K09K1_RS10790	COG2814	Major facilitator Superfamily
K09K1_RS10800	COG1187	pseudouridine synthase activity
K09K1_RS10805	COG1061	Type III restriction enzyme res subunit
K09K1_RS10825	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
K09K1_RS10845	COG3313	Fe-S protein
K09K1_RS10855	COG4134	Bacterial extracellular solute-binding protein
K09K1_RS10860	COG4135	transport system, permease component
K09K1_RS10865	COG4136	ATPase activity
K09K1_RS10870	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K09K1_RS10880	COG3604	Transcriptional regulator
K09K1_RS10885	COG1151	hydroxylamine reductase activity
K09K1_RS10890	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K09K1_RS10900	COG0564	pseudouridine synthase activity
K09K1_RS10905	COG0733	neurotransmitter:sodium symporter activity
K09K1_RS10915	COG0626	cystathionine gamma-synthase activity
K09K1_RS10920	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
K09K1_RS10925	COG5380	lipid catabolic process
K09K1_RS10930	COG2818	Glycosylase
K09K1_RS10950	COG1983	PspC domain protein
K09K1_RS10960	COG1842	Phage shock protein A
K09K1_RS10965	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
K09K1_RS10980	COG4171	peptide transport system, permease
K09K1_RS10990	COG4172	Belongs to the ABC transporter superfamily
K09K1_RS11000	COG1227	inorganic diphosphatase activity
K09K1_RS11015	COG0243	molybdopterin cofactor binding
K09K1_RS11020	COG3005	denitrification pathway
K09K1_RS11025	COG4459	periplasmic nitrate reductase
K09K1_RS11030	COG0390	transport system, permease component
K09K1_RS11040	COG2116	formate transmembrane transporter activity
K09K1_RS11070	COG1435	thymidine kinase activity
K09K1_RS11075	COG0215	cysteine-tRNA ligase activity
K09K1_RS11080	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K09K1_RS11085	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K09K1_RS11090	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
K09K1_RS11095	COG3012	SEC-C Motif Domain Protein
K09K1_RS11100	COG0140	phosphoribosyl-ATP diphosphatase activity
K09K1_RS11100	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K09K1_RS11110	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K09K1_RS11115	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
K09K1_RS11120	COG0131	Imidazoleglycerol-phosphate dehydratase
K09K1_RS11120	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
K09K1_RS11130	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K09K1_RS11140	COG1757	Na H antiporter
K09K1_RS11150	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K09K1_RS11165	COG2915	High frequency lysogenization protein hflD homolog
K09K1_RS11170	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K09K1_RS11180	COG2268	Band 7 protein
K09K1_RS11190	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K09K1_RS11205	COG0300	oxidoreductase activity
K09K1_RS11225	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
K09K1_RS11245	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K09K1_RS11250	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K09K1_RS11270	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K09K1_RS11280	COG1674	ftsk spoiiie
K09K1_RS11290	COG0686	Belongs to the AlaDH PNT family
K09K1_RS11300	COG0583	DNA-binding transcription factor activity
K09K1_RS11325	COG3568	Endonuclease Exonuclease Phosphatase
K09K1_RS11350	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K09K1_RS11355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K09K1_RS11375	COG1271	oxidase subunit
K09K1_RS11380	COG1294	oxidase, subunit
K09K1_RS11395	COG0784	Response regulator, receiver
K09K1_RS11395	COG5002	protein histidine kinase activity
K09K1_RS11405	COG0754	glutathionylspermidine amidase activity
K09K1_RS11415	COG3766	membrane
K09K1_RS11425	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
K09K1_RS11430	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
K09K1_RS11435	COG2885	chlorophyll binding
K09K1_RS11440	COG0823	Involved in the tonB-independent uptake of proteins
K09K1_RS11455	COG0811	peptide transport
K09K1_RS11460	COG0824	Thioesterase
K09K1_RS11470	COG4890	Cyd operon protein YbgT
K09K1_RS11475	COG1294	oxidase, subunit
K09K1_RS11480	COG1271	oxidase subunit
K09K1_RS11485	COG2255	four-way junction helicase activity
K09K1_RS11490	COG0632	four-way junction helicase activity
K09K1_RS11495	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
K09K1_RS11500	COG0217	transcriptional regulatory protein
K09K1_RS11510	COG1801	Protein of unknown function DUF72
K09K1_RS11520	COG0500	methyltransferase
K09K1_RS11530	COG0189	ligase activity
K09K1_RS11530	COG4067	protein conserved in archaea
K09K1_RS11550	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K09K1_RS11555	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
K09K1_RS11560	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
K09K1_RS11565	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K09K1_RS11570	COG1434	Gram-negative-bacterium-type cell wall biogenesis
K09K1_RS11575	COG0745	RESPONSE REGULATOR receiver
K09K1_RS11580	COG3381	protein complex oligomerization
K09K1_RS11585	COG1609	Transcriptional regulator
K09K1_RS11590	COG3070	regulator of competence-specific genes
K09K1_RS11610	COG0297	glycogen (starch) synthase activity
K09K1_RS11615	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K09K1_RS11620	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K09K1_RS11640	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
K09K1_RS11645	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
K09K1_RS11650	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K09K1_RS11655	COG0542	response to heat
K09K1_RS11660	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
K09K1_RS11665	COG1278	Cold shock
K09K1_RS11675	COG1187	pseudouridine synthase activity
K09K1_RS11680	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
K09K1_RS11685	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K09K1_RS11695	COG1199	ATP-dependent helicase activity
K09K1_RS11700	COG0730	response to heat
K09K1_RS11705	COG3923	Primosomal replication protein n
K09K1_RS11715	COG0708	Exodeoxyribonuclease III
K09K1_RS11755	COG1882	Formate acetyltransferase
K09K1_RS11765	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K09K1_RS11775	COG3013	Belongs to the UPF0304 family
K09K1_RS11785	COG2766	serine protein kinase
K09K1_RS11790	COG2718	Belongs to the UPF0229 family
K09K1_RS11795	COG2719	SpoVR family
K09K1_RS11815	COG1132	(ABC) transporter
K09K1_RS11820	COG0658	competence protein
K09K1_RS11820	COG2333	competence protein COMEC
K09K1_RS11830	COG4591	ABC-type transport system involved in lipoprotein release permease component
K09K1_RS11835	COG1136	(ABC) transporter
K09K1_RS11840	COG4591	ABC-type transport system involved in lipoprotein release permease component
K09K1_RS11850	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K09K1_RS11865	COG1252	NADH dehydrogenase
K09K1_RS11870	COG3150	esterase
K09K1_RS11895	COG0537	adenosine 5'-monophosphoramidase activity
K09K1_RS11920	COG0516	GMP reductase activity
K09K1_RS11920	COG0517	IMP dehydrogenase activity
K09K1_RS11925	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K09K1_RS11950	COG3126	Type III secretion system lipoprotein chaperone (YscW)
K09K1_RS11955	COG1946	Acyl-CoA thioesterase
K09K1_RS11965	COG1522	sequence-specific DNA binding
K09K1_RS11970	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K09K1_RS11985	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K09K1_RS11990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K09K1_RS12035	COG0477	Major facilitator Superfamily
K09K1_RS12040	COG2855	membrane
K09K1_RS12060	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
K09K1_RS12070	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
K09K1_RS12075	COG1169	isochorismate synthase
K09K1_RS12080	COG0436	Aminotransferase
K09K1_RS12085	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
K09K1_RS12090	COG0232	Belongs to the dGTPase family. Type 2 subfamily
K09K1_RS12105	COG1555	photosystem II stabilization
K09K1_RS12110	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K09K1_RS12115	COG0776	regulation of translation
K09K1_RS12120	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K09K1_RS12125	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K09K1_RS12135	COG0544	peptidyl-prolyl cis-trans isomerase activity
K09K1_RS12160	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K09K1_RS12165	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K09K1_RS12170	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K09K1_RS12175	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
K09K1_RS12190	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K09K1_RS12195	COG0569	domain protein
K09K1_RS12200	COG0513	Belongs to the DEAD box helicase family
K09K1_RS12235	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K09K1_RS12240	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K09K1_RS12255	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K09K1_RS12260	COG1216	Glycosyl transferase, family 2
K09K1_RS12265	COG2986	histidine ammonia-lyase
K09K1_RS12290	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K09K1_RS12300	COG1028	Short-chain dehydrogenase reductase Sdr
K09K1_RS12310	COG2226	methyltransferase
K09K1_RS12320	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K09K1_RS12325	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K09K1_RS12335	COG2951	lytic endotransglycosylase activity
K09K1_RS12340	COG3100	YcgL domain-containing protein
K09K1_RS12345	COG0850	regulation of cytokinetic process
K09K1_RS12350	COG2894	cell division
K09K1_RS12355	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
K09K1_RS12360	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
K09K1_RS12365	COG0318	PFAM AMP-dependent synthetase and ligase
K09K1_RS12370	COG2267	carboxylic ester hydrolase activity
K09K1_RS12375	COG3065	identical protein binding
K09K1_RS12385	COG1214	PFAM Peptidase M22, glycoprotease
K09K1_RS12390	COG1199	ATP-dependent helicase activity
K09K1_RS12395	COG0788	formyltetrahydrofolate deformylase activity
K09K1_RS12410	COG3102	Protein conserved in bacteria
K09K1_RS12415	COG0018	arginyl-trna synthetase
K09K1_RS12440	COG1918	ferrous iron import across plasma membrane
K09K1_RS12445	COG4977	sequence-specific DNA binding
K09K1_RS12450	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
K09K1_RS12455	COG1121	(ABC) transporter
K09K1_RS12460	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K09K1_RS12470	COG0045	succinate-CoA ligase (ADP-forming) activity
K09K1_RS12475	COG0508	dehydrogenase complex catalyzes the overall conversion of
K09K1_RS12480	COG0567	Dehydrogenase, E1 component
K09K1_RS12485	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K09K1_RS12490	COG1053	succinate dehydrogenase
K09K1_RS12495	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
K09K1_RS12510	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
K09K1_RS12520	COG0033	Phosphoglucomutase
K09K1_RS12525	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
K09K1_RS12530	COG0596	Alpha beta hydrolase
K09K1_RS12540	COG0716	FMN binding
K09K1_RS12550	COG0735	belongs to the Fur family
K09K1_RS12555	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K09K1_RS12560	COG1263	PTS System
K09K1_RS12560	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K09K1_RS12560	COG2190	(PTS) system
K09K1_RS12570	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K09K1_RS12575	COG1940	carbohydrate kinase activity
K09K1_RS12575	COG1846	Transcriptional regulator
K09K1_RS12580	COG4651	solute:proton antiporter activity
K09K1_RS12580	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K09K1_RS12585	COG0367	asparagine synthase
K09K1_RS12590	COG0250	Participates in transcription elongation, termination and antitermination
K09K1_RS12595	COG3104	oligopeptide transport
K09K1_RS12600	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
K09K1_RS12610	COG0326	Molecular chaperone. Has ATPase activity
K09K1_RS12615	COG3710	Transcriptional regulator
K09K1_RS12635	COG0622	Phosphoesterase
K09K1_RS12665	COG1090	epimerase
K09K1_RS12670	COG0300	oxidoreductase activity
K09K1_RS12675	COG3118	belongs to the thioredoxin family
K09K1_RS12680	COG0457	Tetratricopeptide repeat
K09K1_RS12680	COG3118	belongs to the thioredoxin family
K09K1_RS12685	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
K09K1_RS12695	COG1215	transferase activity, transferring glycosyl groups
K09K1_RS12700	COG1192	Involved in chromosome partitioning
K09K1_RS12715	COG2194	sulfuric ester hydrolase activity
K09K1_RS12720	COG0330	HflC and HflK could
K09K1_RS12740	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K09K1_RS12745	COG3115	cell septum assembly
K09K1_RS12750	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
K09K1_RS12755	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K09K1_RS12765	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K09K1_RS12770	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K09K1_RS12775	COG2190	(PTS) system
K09K1_RS12780	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K09K1_RS12785	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K09K1_RS12795	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K09K1_RS12800	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K09K1_RS12810	COG3951	Flagellar rod assembly protein muramidase FlgJ
K09K1_RS12810	COG1705	Flagellar rod assembly protein muramidase FlgJ
K09K1_RS12815	COG1706	bacterial-type flagellum-dependent cell motility
K09K1_RS12820	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
K09K1_RS12830	COG4787	bacterial-type flagellum-dependent cell motility
K09K1_RS12835	COG1749	Flagellar hook protein flgE
K09K1_RS12845	COG1558	bacterial-type flagellum-dependent cell motility
K09K1_RS12850	COG1815	bacterial-type flagellum-dependent cell motility
K09K1_RS12855	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
K09K1_RS12860	COG0784	Response regulator, receiver
K09K1_RS12860	COG0835	chemotaxis
K09K1_RS12915	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
K09K1_RS12930	COG2608	mercury ion transmembrane transporter activity
K09K1_RS12930	COG2217	Heavy metal translocating P-type atpase
K09K1_RS12970	COG2840	Smr protein MutS2
K09K1_RS12975	COG1187	pseudouridine synthase activity
K09K1_RS12980	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K09K1_RS12985	COG0737	Belongs to the 5'-nucleotidase family
K09K1_RS12990	COG2877	3-deoxy-8-phosphooctulonate synthase activity
K09K1_RS12995	COG2912	Transglutaminase-like superfamily
K09K1_RS13000	COG3094	Invasion gene expression up-regulator, SirB
K09K1_RS13005	COG2890	protein-(glutamine-N5) methyltransferase activity
K09K1_RS13015	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
K09K1_RS13020	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
K09K1_RS13025	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K09K1_RS13030	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K09K1_RS13035	COG0193	aminoacyl-tRNA hydrolase activity
K09K1_RS13040	COG0012	GTP binding
K09K1_RS13150	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K09K1_RS13155	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K09K1_RS13160	COG1702	phosphate starvation-inducible protein PhoH
K09K1_RS13165	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K09K1_RS13170	COG4535	Mg2 and Co2 transporter CorC
K09K1_RS13175	COG0815	Transfers the fatty acyl group on membrane lipoproteins
K09K1_RS13180	COG2888	peptidyl-tyrosine sulfation
K09K1_RS13185	COG0495	leucyl-tRNA aminoacylation
K09K1_RS13190	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
K09K1_RS13195	COG1466	dna polymerase III delta subunit
K09K1_RS13200	COG0799	negative regulation of ribosome biogenesis
K09K1_RS13205	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K09K1_RS13210	COG0768	penicillin binding
K09K1_RS13215	COG0772	Belongs to the SEDS family
K09K1_RS13220	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
K09K1_RS13225	COG1686	Belongs to the peptidase S11 family
K09K1_RS13235	COG0321	lipoyl(octanoyl) transferase activity
K09K1_RS13240	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K09K1_RS13245	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K09K1_RS13250	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K09K1_RS13265	COG0366	Alpha amylase catalytic
K09K1_RS13270	COG1263	PTS System
K09K1_RS13270	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K09K1_RS13280	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
K09K1_RS13285	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K09K1_RS13290	COG2011	ABC-type metal ion transport system permease component
K09K1_RS13295	COG1464	Belongs to the NlpA lipoprotein family
K09K1_RS13300	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
K09K1_RS13310	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K09K1_RS13310	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K09K1_RS13325	COG1611	Belongs to the LOG family
K09K1_RS13330	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K09K1_RS13340	COG2363	Small membrane protein
K09K1_RS13350	COG0583	DNA-binding transcription factor activity
K09K1_RS13355	COG0301	tRNA thio-modification
K09K1_RS13355	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K09K1_RS13365	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K09K1_RS13370	COG1722	exodeoxyribonuclease VII activity
K09K1_RS13375	COG0142	geranyltranstransferase activity
K09K1_RS13380	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K09K1_RS13385	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
K09K1_RS13390	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
K09K1_RS13400	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
K09K1_RS13415	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K09K1_RS13415	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K09K1_RS13420	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K09K1_RS13425	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K09K1_RS13430	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K09K1_RS13440	COG1073	alpha beta
K09K1_RS13445	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
K09K1_RS13450	COG2252	PERMEase
K09K1_RS13455	COG2195	Cleaves the N-terminal amino acid of tripeptides
K09K1_RS13485	COG0047	phosphoribosylformylglycinamidine synthase activity
K09K1_RS13485	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K09K1_RS13490	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
K09K1_RS13505	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
K09K1_RS13540	COG0484	heat shock protein binding
K09K1_RS13550	COG1301	dicarboxylic acid transport
K09K1_RS13555	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K09K1_RS13560	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K09K1_RS13570	COG0497	DNA recombination
K09K1_RS13580	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K09K1_RS13585	COG2914	Belongs to the UPF0125 (RnfH) family
K09K1_RS13590	COG2867	negative regulation of translational initiation
K09K1_RS13595	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K09K1_RS13620	COG0583	DNA-binding transcription factor activity
K09K1_RS13625	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K09K1_RS13625	COG3153	acetyltransferase
K09K1_RS13645	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K09K1_RS13650	COG2873	o-acetylhomoserine
K09K1_RS13665	COG1115	amino acid carrier protein
K09K1_RS13670	COG1584	GPR1 FUN34 yaaH family protein
K09K1_RS13680	COG1757	Na H antiporter
K09K1_RS13745	COG0582	viral genome integration into host DNA
K09K1_RS13755	COG0517	IMP dehydrogenase activity
K09K1_RS13755	COG0516	GMP reductase activity
K09K1_RS13775	COG1160	GTP binding
K09K1_RS13780	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K09K1_RS13785	COG2976	Protein conserved in bacteria
K09K1_RS13790	COG0124	histidyl-tRNA synthetase
K09K1_RS13795	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K09K1_RS13810	COG0105	UTP biosynthetic process
K09K1_RS13820	COG2975	iron-sulfur cluster assembly
K09K1_RS13825	COG0633	Ferredoxin
K09K1_RS13830	COG0443	Heat shock 70 kDa protein
K09K1_RS13845	COG0822	iron-sulfur transferase activity
K09K1_RS13850	COG1104	cysteine desulfurase activity
K09K1_RS13860	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
K09K1_RS13865	COG0483	inositol monophosphate 1-phosphatase activity
K09K1_RS13880	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K09K1_RS13885	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K09K1_RS13890	COG1862	Preprotein translocase
K09K1_RS13900	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K09K1_RS13910	COG0517	IMP dehydrogenase activity
K09K1_RS13920	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
K09K1_RS13925	COG0583	DNA-binding transcription factor activity
K09K1_RS13930	COG0450	alkyl hydroperoxide reductase
K09K1_RS13935	COG3142	Participates in the control of copper homeostasis
K09K1_RS13945	COG0704	Plays a role in the regulation of phosphate uptake
K09K1_RS13950	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K09K1_RS13955	COG0581	inorganic phosphate transmembrane transporter activity
K09K1_RS13960	COG0573	inorganic phosphate transmembrane transporter activity
K09K1_RS13965	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K09K1_RS13970	COG0248	Ppx GppA phosphatase
K09K1_RS13980	COG5002	protein histidine kinase activity
K09K1_RS13985	COG0745	RESPONSE REGULATOR receiver
K09K1_RS13995	COG2974	May be involved in recombination
K09K1_RS14000	COG0826	peptidase U32
K09K1_RS14005	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K09K1_RS14070	COG0542	response to heat
K09K1_RS14080	COG0564	pseudouridine synthase activity
K09K1_RS14085	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K09K1_RS14095	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K09K1_RS14100	COG0077	Prephenate dehydratase
K09K1_RS14100	COG1605	Chorismate mutase
K09K1_RS14105	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
K09K1_RS14110	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
K09K1_RS14120	COG0488	(ABC) transporter
K09K1_RS14130	COG0739	heme binding
K09K1_RS14135	COG1605	Chorismate mutase
K09K1_RS14135	COG0287	Prephenate dehydrogenase
K09K1_RS14140	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K09K1_RS14145	COG1472	Belongs to the glycosyl hydrolase 3 family
K09K1_RS14150	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
K09K1_RS14170	COG1966	Carbon starvation protein
K09K1_RS14175	COG3275	phosphorelay sensor kinase activity
K09K1_RS14180	COG3279	Response regulator of the LytR AlgR family
K09K1_RS14190	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K09K1_RS14195	COG1047	Peptidyl-prolyl cis-trans
K09K1_RS14210	COG0196	riboflavin kinase activity
K09K1_RS14215	COG0728	peptidoglycan biosynthetic process
K09K1_RS14220	COG0268	Binds directly to 16S ribosomal RNA
K09K1_RS14225	COG0640	Transcriptional regulator
K09K1_RS14230	COG0583	DNA-binding transcription factor activity
K09K1_RS14235	COG1283	sodium-dependent phosphate transmembrane transporter activity
K09K1_RS14245	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
K09K1_RS14250	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K09K1_RS14255	COG0730	response to heat
K09K1_RS14280	COG0667	Aldo Keto reductase
K09K1_RS14290	COG2204	response regulator
K09K1_RS14305	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K09K1_RS14310	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K09K1_RS14315	COG4974	Belongs to the 'phage' integrase family
K09K1_RS14320	COG0716	FMN binding
K09K1_RS14330	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
K09K1_RS14335	COG0513	Belongs to the DEAD box helicase family
K09K1_RS14340	COG3022	response to hydroperoxide
K09K1_RS14345	COG1115	amino acid carrier protein
K09K1_RS14360	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K09K1_RS14370	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
K09K1_RS14375	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
K09K1_RS14385	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
K09K1_RS14390	COG0083	homoserine kinase activity
K09K1_RS14410	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K09K1_RS14425	COG0745	RESPONSE REGULATOR receiver
K09K1_RS14435	COG2198	Histidine kinase
K09K1_RS14435	COG0784	Response regulator, receiver
K09K1_RS14435	COG5002	protein histidine kinase activity
K09K1_RS14440	COG5001	Diguanylate cyclase
K09K1_RS14440	COG3706	GGDEF domain
K09K1_RS14440	COG2203	Gaf domain
K09K1_RS14440	COG4251	negative regulation of phosphorylation
K09K1_RS14445	COG1242	4 iron, 4 sulfur cluster binding
K09K1_RS14450	COG0069	glutamate synthase activity
K09K1_RS14450	COG0070	glutamate synthase
K09K1_RS14450	COG0067	glutamate synthase
K09K1_RS14460	COG0067	glutamate synthase
K09K1_RS14460	COG0070	glutamate synthase
K09K1_RS14460	COG0069	glutamate synthase activity
K09K1_RS14465	COG0493	'glutamate synthase
K09K1_RS14475	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K09K1_RS14490	COG2860	membrane
K09K1_RS14495	COG0583	DNA-binding transcription factor activity
K09K1_RS14500	COG0730	response to heat
K09K1_RS14515	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K09K1_RS14520	COG0505	Belongs to the CarA family
K09K1_RS14530	COG0494	nUDIX hydrolase
K09K1_RS14535	COG0653	protein targeting
K09K1_RS14545	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
K09K1_RS14550	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K09K1_RS14555	COG0849	cell division
K09K1_RS14560	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K09K1_RS14575	COG0772	Belongs to the SEDS family
K09K1_RS14580	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K09K1_RS14585	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K09K1_RS14590	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K09K1_RS14595	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K09K1_RS14600	COG0768	penicillin binding
K09K1_RS14605	COG3116	cell division
K09K1_RS14625	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
K09K1_RS14640	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
K09K1_RS14645	COG2823	Periplasmic or secreted lipoprotein
K09K1_RS14655	COG2969	positive regulation of protein catabolic process
K09K1_RS14660	COG0625	glutathione transferase activity
K09K1_RS14665	COG2857	Cytochrome c1
K09K1_RS14670	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K09K1_RS14675	COG0723	plastoquinol--plastocyanin reductase activity
K09K1_RS14680	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K09K1_RS14695	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
K09K1_RS14700	COG3105	Protein conserved in bacteria
K09K1_RS14710	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K09K1_RS14715	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K09K1_RS14725	COG3150	esterase
K09K1_RS14735	COG3151	Protein conserved in bacteria
K09K1_RS14740	COG0494	nUDIX hydrolase
K09K1_RS14745	COG1538	Outer membrane efflux protein
K09K1_RS14750	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
K09K1_RS14750	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
K09K1_RS14755	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
K09K1_RS14770	COG3025	triphosphatase activity
K09K1_RS14775	COG1392	Phosphate transport regulator
K09K1_RS14780	COG0306	phosphate transporter
K09K1_RS14785	COG4991	sh3 domain protein
K09K1_RS14790	COG0405	Gamma-glutamyltransferase
K09K1_RS14800	COG3267	Type II secretory pathway component ExeA
K09K1_RS14800	COG3409	Peptidoglycan-binding domain 1 protein
K09K1_RS14810	COG1968	undecaprenyl-diphosphatase activity
K09K1_RS14815	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K09K1_RS14820	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
K09K1_RS14825	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
K09K1_RS14830	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K09K1_RS14835	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K09K1_RS14840	COG0828	Belongs to the bacterial ribosomal protein bS21 family
K09K1_RS14845	COG1610	YqeY-like protein
K09K1_RS14850	COG0358	DNA primase activity
K09K1_RS14885	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K09K1_RS14885	COG2213	PTS system mannitol-specific
K09K1_RS14895	COG3722	fumarate hydratase activity
K09K1_RS14910	COG1461	Dihydroxyacetone kinase
K09K1_RS14915	COG2376	Dihydroxyacetone kinase
K09K1_RS14925	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K09K1_RS14930	COG1349	DNA-binding transcription factor activity
K09K1_RS14935	COG0469	pyruvate kinase activity
K09K1_RS14950	COG0440	acetolactate synthase activity
K09K1_RS14955	COG0028	Belongs to the TPP enzyme family
K09K1_RS14960	COG1022	Amp-dependent synthetase and ligase
K09K1_RS14965	COG0583	DNA-binding transcription factor activity
K09K1_RS14990	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K09K1_RS14995	COG0473	3-isopropylmalate dehydrogenase activity
K09K1_RS15015	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
K09K1_RS15020	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
K09K1_RS15025	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K09K1_RS15030	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
K09K1_RS15035	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K09K1_RS15040	COG2967	ApaG domain
K09K1_RS15045	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
K09K1_RS15050	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
K09K1_RS15060	COG2966	Psort location CytoplasmicMembrane, score
K09K1_RS15065	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K09K1_RS15075	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K09K1_RS15080	COG0142	geranyltranstransferase activity
K09K1_RS15105	COG2358	TRAP transporter, solute receptor (TAXI family
K09K1_RS15125	COG1902	pentaerythritol trinitrate reductase activity
K09K1_RS15130	COG0583	DNA-binding transcription factor activity
K09K1_RS15135	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
K09K1_RS15140	COG1178	ABC-type Fe3 transport system permease component
K09K1_RS15145	COG4143	(ABC) transporter
K09K1_RS15150	COG0163	prenyltransferase activity
K09K1_RS15155	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K09K1_RS15160	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
K09K1_RS15165	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
K09K1_RS15175	COG2105	PFAM AIG2 family protein
K09K1_RS15180	COG2911	Protein conserved in bacteria
K09K1_RS15185	COG0729	surface antigen
K09K1_RS15190	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K09K1_RS15200	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
K09K1_RS15215	COG4181	ATPase activity
K09K1_RS15235	COG0529	Catalyzes the synthesis of activated sulfate
K09K1_RS15240	COG0471	metal ion transport
K09K1_RS15240	COG3273	potassium ion transport
K09K1_RS15245	COG2895	sulfate adenylyltransferase (ATP) activity
K09K1_RS15250	COG0175	sulfate reduction
K09K1_RS15255	COG1648	precorrin-2 dehydrogenase activity
K09K1_RS15255	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K09K1_RS15270	COG0513	Belongs to the DEAD box helicase family
K09K1_RS15275	COG2153	protein acetylation
K09K1_RS15285	COG0545	Peptidyl-prolyl cis-trans isomerase
K09K1_RS15295	COG0203	ribosomal protein L17
K09K1_RS15300	COG0202	RNA polymerase activity
K09K1_RS15310	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K09K1_RS15315	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K09K1_RS15320	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K09K1_RS15325	COG0201	protein transport
K09K1_RS15330	COG0200	Binds to the 23S rRNA
K09K1_RS15335	COG1841	ribosomal large subunit assembly
K09K1_RS15350	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K09K1_RS15355	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K09K1_RS15360	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K09K1_RS15365	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K09K1_RS15370	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K09K1_RS15380	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K09K1_RS15385	COG0255	Belongs to the universal ribosomal protein uL29 family
K09K1_RS15395	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K09K1_RS15400	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K09K1_RS15405	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K09K1_RS15410	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K09K1_RS15420	COG0088	Forms part of the polypeptide exit tunnel
K09K1_RS15425	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K09K1_RS15435	COG0254	rRNA binding
K09K1_RS15445	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K09K1_RS15450	COG1609	Transcriptional regulator
K09K1_RS15460	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
K09K1_RS15465	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K09K1_RS15480	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
K09K1_RS15490	COG3051	citrate lyase alpha subunit
K09K1_RS15495	COG2301	Belongs to the HpcH HpaI aldolase family
K09K1_RS15505	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
K09K1_RS15515	COG3630	sodium ion export across plasma membrane
K09K1_RS15520	COG5016	pyruvate
K09K1_RS15520	COG0511	ligase activity, forming carbon-carbon bonds
K09K1_RS15525	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
K09K1_RS15535	COG4565	transcriptional regulatory protein
K09K1_RS15550	COG2003	Belongs to the UPF0758 family
K09K1_RS15580	COG1575	Belongs to the MenA family. Type 1 subfamily
K09K1_RS15585	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K09K1_RS15595	COG1494	fructose-1,6-bisphosphatase
K09K1_RS15625	COG0149	triose-phosphate isomerase activity
K09K1_RS15650	COG1215	transferase activity, transferring glycosyl groups
K09K1_RS15685	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K09K1_RS15690	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
K09K1_RS15695	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K09K1_RS15705	COG0438	transferase activity, transferring glycosyl groups
K09K1_RS15705	COG0297	glycogen (starch) synthase activity
K09K1_RS15715	COG0438	transferase activity, transferring glycosyl groups
K09K1_RS15765	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K09K1_RS15795	COG0859	PFAM glycosyl transferase family 9
K09K1_RS15800	COG1519	Transferase
K09K1_RS15805	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K09K1_RS15845	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
K09K1_RS15855	COG3642	lipopolysaccharide core region biosynthetic process
K09K1_RS15860	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K09K1_RS15865	COG0859	PFAM glycosyl transferase family 9
K09K1_RS15870	COG0463	Glycosyl transferase, family 2
K09K1_RS15885	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K09K1_RS15910	COG2003	Belongs to the UPF0758 family
K09K1_RS15920	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K09K1_RS15925	COG1309	transcriptional regulator
K09K1_RS15930	COG1560	Kdo2-lipid A biosynthetic process
K09K1_RS15935	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K09K1_RS15940	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
K09K1_RS15950	COG1561	YicC-like family, N-terminal region
K09K1_RS15960	COG4608	Belongs to the ABC transporter superfamily
K09K1_RS15965	COG0444	Belongs to the ABC transporter superfamily
K09K1_RS15970	COG0747	negative chemotaxis
K09K1_RS15975	COG4239	(ABC) transporter, permease
K09K1_RS15980	COG4174	ABC transporter (Permease)
K09K1_RS16005	COG0811	peptide transport
K09K1_RS16010	COG0848	biopolymer transport protein
K09K1_RS16025	COG0194	GDP metabolic process
K09K1_RS16030	COG1758	RNA polymerase activity
K09K1_RS16035	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K09K1_RS16040	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K09K1_RS16045	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K09K1_RS16050	COG2233	PERMEase
K09K1_RS16070	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K09K1_RS16080	COG2183	response to ionizing radiation
K09K1_RS16095	COG1040	competence protein
K09K1_RS16105	COG0494	nUDIX hydrolase
K09K1_RS16110	COG1218	3'(2'),5'-bisphosphate nucleotidase
K09K1_RS16120	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
K09K1_RS16125	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
K09K1_RS16130	COG3156	type II secretion system protein K
K09K1_RS16135	COG4795	General secretion pathway protein
K09K1_RS16140	COG2165	general secretion pathway protein
K09K1_RS16145	COG2165	general secretion pathway protein
K09K1_RS16150	COG2165	general secretion pathway protein
K09K1_RS16155	COG1459	type II secretion system
K09K1_RS16160	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K09K1_RS16170	COG3031	protein transport across the cell outer membrane
K09K1_RS16175	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
K09K1_RS16180	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
K09K1_RS16185	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
K09K1_RS16195	COG0456	acetyltransferase
K09K1_RS16200	COG1490	D-aminoacyl-tRNA deacylase activity
K09K1_RS16205	COG1295	ribonuclease BN
K09K1_RS16215	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K09K1_RS16220	COG1217	gtp-binding protein TYPA
K09K1_RS16225	COG0174	glutamine synthetase
K09K1_RS16235	COG3852	Histidine kinase
K09K1_RS16240	COG2204	response regulator
K09K1_RS16250	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K09K1_RS16285	COG0218	Necessary for normal cell division and for the maintenance of normal septation
K09K1_RS16290	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K09K1_RS16290	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K09K1_RS16300	COG0456	acetyltransferase
K09K1_RS16315	COG0084	hydrolase, TatD family'
K09K1_RS16325	COG0805	protein transport
K09K1_RS16330	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K09K1_RS16340	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K09K1_RS16345	COG3165	ubiquinone biosynthetic process from chorismate
K09K1_RS16350	COG2226	methyltransferase
K09K1_RS16355	COG1322	Protein conserved in bacteria
K09K1_RS16370	COG0628	permease
K09K1_RS16400	COG1597	lipid kinase activity
K09K1_RS16430	COG2081	HI0933 family
K09K1_RS16440	COG1528	Iron-storage protein
K09K1_RS16445	COG0589	response to stress
K09K1_RS16460	COG0742	ribosomal rna small subunit methyltransferase
K09K1_RS16465	COG5001	Diguanylate cyclase
K09K1_RS16465	COG5002	protein histidine kinase activity
K09K1_RS16470	COG1522	sequence-specific DNA binding
K09K1_RS16480	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
K09K1_RS16485	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K09K1_RS16490	COG0583	DNA-binding transcription factor activity
K09K1_RS16495	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
K09K1_RS16500	COG0800	Aldolase
K09K1_RS16505	COG2610	gluconate transmembrane transporter activity
K09K1_RS16510	COG3265	gluconokinase activity
K09K1_RS16515	COG0129	dihydroxy-acid dehydratase activity
K09K1_RS16530	COG0583	DNA-binding transcription factor activity
K09K1_RS16535	COG1609	Transcriptional regulator
K09K1_RS16545	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K09K1_RS16550	COG0601	transmembrane transport
K09K1_RS16555	COG4166	transmembrane transport
K09K1_RS16615	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K09K1_RS16620	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K09K1_RS16630	COG2960	long-chain fatty acid transporting porin activity
K09K1_RS16635	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K09K1_RS16640	COG0583	DNA-binding transcription factor activity
K09K1_RS16685	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K09K1_RS16690	COG1739	Uncharacterized protein family UPF0029
K09K1_RS16700	COG0183	Belongs to the thiolase family
K09K1_RS16705	COG0604	alcohol dehydrogenase
K09K1_RS16720	COG0425	Belongs to the sulfur carrier protein TusA family
K09K1_RS16730	COG2119	membrane
K09K1_RS16745	COG0366	Alpha amylase catalytic
K09K1_RS16750	COG3977	Valine--pyruvate aminotransferase
K09K1_RS16755	COG0071	Belongs to the small heat shock protein (HSP20) family
K09K1_RS16775	COG0187	DNA topoisomerase II activity
K09K1_RS16785	COG0592	DNA-directed DNA polymerase activity
K09K1_RS16790	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K09K1_RS16810	COG1126	abc transporter atp-binding protein
K09K1_RS16820	COG0594	ribonuclease P activity
K09K1_RS16830	COG0706	membrane insertase activity
K09K1_RS16840	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K09K1_RS16845	COG0445	tRNA wobble uridine modification
K09K1_RS16850	COG0357	Ribosomal RNA small subunit methyltransferase G
K09K1_RS16855	COG1192	Involved in chromosome partitioning
K09K1_RS16860	COG1475	DNA binding
K09K1_RS16865	COG3312	ion transport
K09K1_RS16870	COG0356	it plays a direct role in the translocation of protons across the membrane
K09K1_RS16880	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K09K1_RS16885	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K09K1_RS16890	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K09K1_RS16895	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K09K1_RS16900	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K09K1_RS16905	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K09K1_RS16915	COG0765	amino acid transport
K09K1_RS16925	COG2814	Major facilitator Superfamily
K09K1_RS16930	COG0583	DNA-binding transcription factor activity
K09K1_RS16940	COG0129	dihydroxy-acid dehydratase activity
K09K1_RS16945	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K09K1_RS16950	COG3978	acetolactate synthase activity
K09K1_RS16970	COG0204	Acyl-transferase
K09K1_RS16975	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K09K1_RS16980	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
K09K1_RS16990	COG3084	Protein conserved in bacteria
K09K1_RS17000	COG4326	sporulation control protein
K09K1_RS17005	COG1272	protein, Hemolysin III
K09K1_RS17015	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K09K1_RS17020	COG0569	domain protein
K09K1_RS17025	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K09K1_RS17025	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K09K1_RS17030	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K09K1_RS17035	COG0242	peptide deformylase activity
K09K1_RS17045	COG0758	DNA mediated transformation
K09K1_RS17050	COG2922	Belongs to the Smg family
K09K1_RS17055	COG0551	DNA topoisomerase type I activity
K09K1_RS17060	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K09K1_RS17065	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
K09K1_RS17070	COG0009	L-threonylcarbamoyladenylate synthase
K09K1_RS17090	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
K09K1_RS17140	COG2132	Multicopper oxidase
K09K1_RS17160	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K09K1_RS17165	COG2104	thiamine diphosphate biosynthetic process
K09K1_RS17180	COG0006	proline dipeptidase activity
K09K1_RS17180	COG0006	proline dipeptidase activity
K09K1_RS17210	COG3220	belongs to the UPF0276 family
K09K1_RS17220	COG0210	DNA helicase
K09K1_RS17225	COG0405	Gamma-glutamyltransferase
K09K1_RS17230	COG1280	lysine exporter protein (LysE YggA)
K09K1_RS17240	COG2962	Rard protein
K09K1_RS17245	COG0514	ATP-dependent DNA helicase (RecQ)
K09K1_RS17255	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
K09K1_RS17265	COG0248	Ppx GppA phosphatase
K09K1_RS17270	COG0513	Belongs to the DEAD box helicase family
K09K1_RS17275	COG3118	belongs to the thioredoxin family
K09K1_RS17290	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
K09K1_RS17295	COG0633	Ferredoxin
K09K1_RS17340	COG2959	enzyme of heme biosynthesis
K09K1_RS17345	COG1587	Uroporphyrinogen-III synthase
K09K1_RS17350	COG0181	hydroxymethylbilane synthase activity
K09K1_RS17355	COG3072	Adenylate cyclase
K09K1_RS17360	COG1965	Belongs to the frataxin family
K09K1_RS17370	COG0019	diaminopimelate decarboxylase activity
K09K1_RS17385	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
K09K1_RS17390	COG1011	Hydrolase
K09K1_RS17395	COG3287	FIST C domain
K09K1_RS17395	COG2200	EAL domain
K09K1_RS17395	COG2199	diguanylate cyclase activity
K09K1_RS17400	COG3148	PFAM DTW domain containing protein
K09K1_RS17415	COG0561	phosphatase activity
K09K1_RS17420	COG2267	carboxylic ester hydrolase activity
K09K1_RS17425	COG1280	lysine exporter protein (LysE YggA)
K09K1_RS17430	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
K09K1_RS17435	COG0640	Transcriptional regulator
K09K1_RS17440	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K09K1_RS17485	COG2095	MarC family integral membrane protein
K09K1_RS17495	COG0742	ribosomal rna small subunit methyltransferase
K09K1_RS17500	COG0552	protein localization to endoplasmic reticulum
K09K1_RS17505	COG2884	Cell division ATP-binding protein ftsE
K09K1_RS17510	COG2177	Part of the ABC transporter FtsEX involved in
K09K1_RS17525	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K09K1_RS17530	COG0705	Rhomboid family
K09K1_RS17535	COG1580	Controls the rotational direction of flagella during chemotaxis
K09K1_RS17540	COG3161	chorismate lyase activity
K09K1_RS17545	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
K09K1_RS17550	COG2937	Belongs to the GPAT DAPAT family
K09K1_RS17560	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K09K1_RS17570	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
K09K1_RS17575	COG0534	Mate efflux family protein
K09K1_RS17580	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K09K1_RS17600	COG4206	TonB-dependent receptor
K09K1_RS17675	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K09K1_RS17685	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K09K1_RS17690	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
K09K1_RS17690	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
K09K1_RS17725	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K09K1_RS17735	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K09K1_RS17740	COG0250	Participates in transcription elongation, termination and antitermination
K09K1_RS17755	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K09K1_RS17760	COG0222	ribosome binding
K09K1_RS17765	COG0085	RNA polymerase activity
K09K1_RS17770	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K09K1_RS17775	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
K09K1_RS17780	COG2816	NAD+ diphosphatase activity
K09K1_RS17785	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K09K1_RS17790	COG1573	uracil-dna glycosylase
K09K1_RS17800	COG3068	Protein conserved in bacteria
K09K1_RS17805	COG1253	flavin adenine dinucleotide binding
K09K1_RS17820	COG0151	Belongs to the GarS family
K09K1_RS17835	COG0789	Transcriptional regulator
K09K1_RS17840	COG3710	Transcriptional regulator
K09K1_RS17850	COG0531	amino acid
K09K1_RS17855	COG1982	Orn Lys Arg decarboxylase major
K09K1_RS17905	COG0488	(ABC) transporter
K09K1_RS17915	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
K09K1_RS17920	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K09K1_RS17925	COG2264	protein methyltransferase activity
K09K1_RS17930	COG0439	Biotin carboxylase
K09K1_RS17935	COG0511	ligase activity, forming carbon-carbon bonds
K09K1_RS17940	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K09K1_RS17945	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K09K1_RS17960	COG2814	Major facilitator Superfamily
K09K1_RS17985	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K09K1_RS17995	COG3263	regulation of cellular component size
K09K1_RS18005	COG4232	protein-disulfide reductase activity
K09K1_RS18010	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
K09K1_RS18015	COG1027	Aspartate ammonia-lyase
K09K1_RS18020	COG3030	protein affecting phage T7 exclusion by the F plasmid
K09K1_RS18025	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
K09K1_RS18035	COG2205	protein histidine kinase activity
K09K1_RS18040	COG0745	RESPONSE REGULATOR receiver
K09K1_RS18045	COG3678	ATP-independent chaperone mediated protein folding
K09K1_RS18055	COG0205	6-phosphofructokinase activity
K09K1_RS18060	COG0534	Mate efflux family protein
K09K1_RS18075	COG0459	protein refolding
K09K1_RS18085	COG1285	pathogenesis
K09K1_RS18090	COG1509	lysine 2,3-aminomutase activity
K09K1_RS18105	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
K09K1_RS18110	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
K09K1_RS18115	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K09K1_RS18120	COG1053	succinate dehydrogenase
K09K1_RS18125	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
K09K1_RS18145	COG4942	peptidase
K09K1_RS18150	COG1045	serine acetyltransferase
K09K1_RS18155	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K09K1_RS18160	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
K09K1_RS18165	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K09K1_RS18170	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
K09K1_RS18180	COG0471	metal ion transport
K09K1_RS18185	COG0688	phosphatidylethanolamine metabolic process
K09K1_RS18190	COG1162	GTPase activity
K09K1_RS18195	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
K09K1_RS18260	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K09K1_RS18270	COG0802	atpase or kinase
K09K1_RS18280	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K09K1_RS18285	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K09K1_RS18295	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K09K1_RS18300	COG0330	HflC and HflK could
K09K1_RS18305	COG0330	HflC and HflK could
K09K1_RS18310	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
K09K1_RS18315	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K09K1_RS18320	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
K09K1_RS18325	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K09K1_RS18325	COG1017	nitric oxide dioxygenase activity
K09K1_RS18330	COG1959	2 iron, 2 sulfur cluster binding
K09K1_RS18335	COG0557	exoribonuclease II activity
K09K1_RS18340	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K09K1_RS18345	COG0546	phosphoglycolate phosphatase activity
K09K1_RS18350	COG0180	Tryptophanyl-tRNA synthetase
K09K1_RS18365	COG0512	Glutamine amidotransferase of anthranilate synthase
K09K1_RS18370	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K09K1_RS18390	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K09K1_RS18395	COG3954	Phosphoribulokinase
K09K1_RS18405	COG0429	hydrolase of the alpha beta-hydrolase fold
K09K1_RS18415	COG0488	(ABC) transporter
K09K1_RS18420	COG2249	NAD(P)H dehydrogenase (quinone) activity
K09K1_RS18435	COG1047	Peptidyl-prolyl cis-trans
K09K1_RS18445	COG1446	asparaginase
K09K1_RS18460	COG0545	Peptidyl-prolyl cis-trans isomerase
K09K1_RS18465	COG2964	Protein conserved in bacteria
K09K1_RS18470	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
K09K1_RS18475	COG2923	Belongs to the DsrF TusC family
K09K1_RS18495	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K09K1_RS18500	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K09K1_RS18515	COG0281	malic enzyme
K09K1_RS18520	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
K09K1_RS18525	COG0626	cystathionine gamma-synthase activity
K09K1_RS18530	COG0460	homoserine dehydrogenase
K09K1_RS18530	COG0527	aspartate kinase activity
K09K1_RS18535	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K09K1_RS18545	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
K09K1_RS18555	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
K09K1_RS18565	COG0137	argininosuccinate synthase activity
K09K1_RS18570	COG0165	Argininosuccinate lyase
K09K1_RS18570	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
K09K1_RS18585	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K09K1_RS18590	COG0678	peroxiredoxin activity
K09K1_RS18590	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K09K1_RS18600	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
K09K1_RS18630	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K09K1_RS18635	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K09K1_RS18645	COG0338	D12 class N6 adenine-specific DNA methyltransferase
K09K1_RS18650	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K09K1_RS18655	COG0360	Binds together with S18 to 16S ribosomal RNA
K09K1_RS18660	COG2965	DNA replication, synthesis of RNA primer
K09K1_RS18685	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K09K1_RS18690	COG0432	Pfam Uncharacterised protein family UPF0047
K09K1_RS18695	COG0166	Belongs to the GPI family
K09K1_RS18705	COG0735	belongs to the Fur family
K09K1_RS18710	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K09K1_RS18730	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K09K1_RS18735	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K09K1_RS18740	COG0175	sulfate reduction
K09K1_RS18810	COG0646	methionine synthase
K09K1_RS18810	COG1410	methionine synthase
K09K1_RS18815	COG0527	aspartate kinase activity
K09K1_RS18825	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
K09K1_RS18840	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K09K1_RS18855	COG0629	single-stranded DNA binding
K09K1_RS18860	COG2200	EAL domain
K09K1_RS18860	COG2199	diguanylate cyclase activity
K09K1_RS18880	COG1450	Type ii and iii secretion system protein
K09K1_RS18885	COG3409	Peptidoglycan-binding domain 1 protein
K09K1_RS18885	COG3267	Type II secretory pathway component ExeA
K09K1_RS18895	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K09K1_RS18900	COG1459	type II secretion system
K09K1_RS18910	COG2165	general secretion pathway protein
K09K1_RS18945	COG1077	Cell shape determining protein MreB Mrl
K09K1_RS18950	COG1792	Involved in formation and maintenance of cell shape
K09K1_RS18955	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
K09K1_RS18960	COG0424	maF-like protein
K09K1_RS18970	COG3164	Protein of unknown function
K09K1_RS18975	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K09K1_RS18980	COG0312	modulator of DNA gyrase
K09K1_RS18985	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
K09K1_RS18990	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K09K1_RS19000	COG0564	pseudouridine synthase activity
K09K1_RS19005	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K09K1_RS19010	COG3028	Belongs to the UPF0307 family
K09K1_RS19015	COG0312	modulator of DNA gyrase
K09K1_RS19020	COG2239	Acts as a magnesium transporter
K09K1_RS19025	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K09K1_RS19030	COG1660	Displays ATPase and GTPase activities
K09K1_RS19035	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K09K1_RS19040	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K09K1_RS19050	COG1137	ATPase activity
K09K1_RS19055	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
K09K1_RS19065	COG0517	IMP dehydrogenase activity
K09K1_RS19065	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
K09K1_RS19075	COG1127	ABC transporter
K09K1_RS19080	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K09K1_RS19085	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K09K1_RS19090	COG2854	intermembrane phospholipid transfer
K09K1_RS19100	COG5007	Belongs to the BolA IbaG family
K09K1_RS19105	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K09K1_RS19110	COG0204	Acyl-transferase
K09K1_RS19115	COG0251	oxidation-reduction process
K09K1_RS19120	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
K09K1_RS19125	COG0540	Belongs to the ATCase OTCase family
K09K1_RS19155	COG0456	acetyltransferase
K09K1_RS19165	COG0525	valine-tRNA ligase activity
K09K1_RS19170	COG2927	DNA polymerase III (CHI subunit)
K09K1_RS19175	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K09K1_RS19180	COG0795	lipopolysaccharide-transporting ATPase activity
K09K1_RS19185	COG0795	lipopolysaccharide-transporting ATPase activity
K09K1_RS19200	COG1028	Short-chain dehydrogenase reductase Sdr
K09K1_RS19210	COG0726	polysaccharide deacetylase
K09K1_RS19215	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K09K1_RS19220	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K09K1_RS19225	COG1447	Phosphotransferase system cellobiose-specific component IIA
K09K1_RS19230	COG1486	melibiose metabolic process
K09K1_RS19235	COG3394	polysaccharide catabolic process
K09K1_RS19240	COG1609	Transcriptional regulator
K09K1_RS19245	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
K09K1_RS19325	COG0840	transmembrane signaling receptor activity
K09K1_RS19370	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
K09K1_RS19380	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K09K1_RS19390	COG2066	Belongs to the glutaminase family
K09K1_RS19395	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K09K1_RS19400	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
K09K1_RS19410	COG1872	DUF167
K09K1_RS19415	COG0762	integral membrane protein
K09K1_RS19420	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K09K1_RS19425	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K09K1_RS19440	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K09K1_RS19445	COG1678	Uncharacterized ACR, COG1678
K09K1_RS19450	COG0189	ligase activity
K09K1_RS19455	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K09K1_RS19460	COG2356	endonuclease I
K09K1_RS19465	COG3091	SprT-like family
K09K1_RS19475	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K09K1_RS19485	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K09K1_RS19490	COG0583	DNA-binding transcription factor activity
K09K1_RS19495	COG4771	TonB-dependent receptor
K09K1_RS19510	COG0191	fructose-bisphosphate aldolase activity
K09K1_RS19515	COG0668	transmembrane transport
K09K1_RS19530	COG0583	DNA-binding transcription factor activity
K09K1_RS19540	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K09K1_RS19545	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
K09K1_RS19550	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K09K1_RS19560	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
K09K1_RS19565	COG3079	Belongs to the UPF0149 family
K09K1_RS19570	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K09K1_RS19575	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K09K1_RS19595	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
K09K1_RS19605	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
K09K1_RS19610	COG1595	DNA-templated transcription, initiation
K09K1_RS19625	COG3086	response to oxidative stress
K09K1_RS19630	COG0481	GTPase activity
K09K1_RS19635	COG0681	Belongs to the peptidase S26 family
K09K1_RS19645	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K09K1_RS19650	COG1381	Involved in DNA repair and RecF pathway recombination
K09K1_RS19655	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
K09K1_RS19660	COG0736	holo-[acyl-carrier-protein] synthase activity
K09K1_RS19675	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K09K1_RS19680	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K09K1_RS19685	COG3956	TIGRFAM MazG family protein
K09K1_RS19690	COG0504	CTP synthase activity
K09K1_RS19695	COG0148	phosphopyruvate hydratase activity
K09K1_RS19700	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
K09K1_RS19705	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
K09K1_RS19710	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
K09K1_RS19720	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
K09K1_RS19725	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K09K1_RS19735	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K09K1_RS19740	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K09K1_RS19745	COG1546	Belongs to the CinA family
K09K1_RS19750	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K09K1_RS19755	COG2137	regulation of response to DNA damage stimulus
K09K1_RS19760	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K09K1_RS19765	COG0527	aspartate kinase activity
K09K1_RS19825	COG3630	sodium ion export across plasma membrane
K09K1_RS19830	COG5016	pyruvate
K09K1_RS19830	COG0511	ligase activity, forming carbon-carbon bonds
K09K1_RS19835	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
K09K1_RS19845	COG1238	metal cluster binding
K09K1_RS19850	COG0612	Peptidase, M16
K09K1_RS19865	COG1854	S-ribosylhomocysteine lyase activity
K09K1_RS19870	COG4536	flavin adenine dinucleotide binding
K09K1_RS19875	COG4137	Cytochrome C assembly protein
K09K1_RS19880	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K09K1_RS19885	COG0228	four-way junction DNA binding
K09K1_RS19890	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K09K1_RS19905	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
K09K1_RS19910	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
K09K1_RS19915	COG0237	dephospho-CoA kinase activity
K09K1_RS19925	COG1459	type II secretion system
K09K1_RS19930	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K09K1_RS19935	COG4969	Belongs to the N-Me-Phe pilin family
K09K1_RS19940	COG0157	Belongs to the NadC ModD family
K09K1_RS19950	COG2186	Transcriptional regulator
K09K1_RS19955	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
K09K1_RS19960	COG0508	dehydrogenase complex catalyzes the overall conversion of
K09K1_RS19965	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K09K1_RS19980	COG0288	reversible hydration of carbon dioxide
K09K1_RS19985	COG0659	secondary active sulfate transmembrane transporter activity
K09K1_RS19990	COG1131	(ABC) transporter
K09K1_RS19995	COG0842	Transport permease protein
K09K1_RS20005	COG1560	Kdo2-lipid A biosynthetic process
K09K1_RS20010	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
K09K1_RS20015	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
K09K1_RS20020	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K09K1_RS20030	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K09K1_RS20040	COG1489	DNA binding
K09K1_RS20045	COG1643	Atp-dependent helicase
K09K1_RS20050	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K09K1_RS20055	COG1752	Esterase of the alpha-beta hydrolase superfamily
K09K1_RS20060	COG1049	propionate catabolic process, 2-methylcitrate cycle
K09K1_RS20065	COG3112	Uncharacterised protein family (UPF0231)
K09K1_RS20075	COG0004	ammonium transporteR
K09K1_RS20080	COG1840	ABC-type Fe3 transport system, periplasmic component
K09K1_RS20090	COG3842	ATPase activity
K09K1_RS20110	COG2971	BadF BadG BcrA BcrD
K09K1_RS20120	COG4608	Belongs to the ABC transporter superfamily
K09K1_RS20125	COG0444	Belongs to the ABC transporter superfamily
K09K1_RS20130	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K09K1_RS20140	COG0747	negative chemotaxis
K09K1_RS20145	COG2205	protein histidine kinase activity
K09K1_RS20145	COG0784	Response regulator, receiver
K09K1_RS20155	COG0628	permease
K09K1_RS20180	COG0739	heme binding
K09K1_RS20185	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K09K1_RS20195	COG2027	D-alanyl-D-alanine carboxypeptidase
K09K1_RS20200	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K09K1_RS20205	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K09K1_RS20210	COG1534	Rna-binding protein
K09K1_RS20215	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
K09K1_RS20220	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K09K1_RS20225	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
K09K1_RS20230	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K09K1_RS20240	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K09K1_RS20255	COG0779	Required for maturation of 30S ribosomal subunits
K09K1_RS20260	COG0195	Participates in both transcription termination and antitermination
K09K1_RS20265	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K09K1_RS20270	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K09K1_RS20275	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K09K1_RS20280	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K09K1_RS20285	COG1185	polyribonucleotide nucleotidyltransferase activity
K09K1_RS20300	COG0534	Mate efflux family protein
K09K1_RS20305	COG0826	peptidase U32
K09K1_RS20310	COG0826	peptidase U32
K09K1_RS20325	COG3154	lipid carrier protein
K09K1_RS20330	COG3153	acetyltransferase
K09K1_RS20360	COG0084	hydrolase, TatD family'
K09K1_RS20365	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K09K1_RS20370	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
K09K1_RS20375	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
K09K1_RS20380	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
K09K1_RS20385	COG0813	purine-nucleoside phosphorylase activity
K09K1_RS20395	COG0560	Phosphoserine phosphatase
K09K1_RS20405	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
K09K1_RS20410	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K09K1_RS20415	COG0583	DNA-binding transcription factor activity
K09K1_RS20425	COG1022	Amp-dependent synthetase and ligase
K09K1_RS20465	COG0583	DNA-binding transcription factor activity
K09K1_RS20470	COG1609	Transcriptional regulator
K09K1_RS20490	COG0598	Magnesium transport protein CorA
K09K1_RS20495	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
K09K1_RS20500	COG1349	DNA-binding transcription factor activity
K09K1_RS20505	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
K09K1_RS20510	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K09K1_RS20520	COG2271	Major facilitator Superfamily
K09K1_RS20525	COG0584	glycerophosphoryl diester phosphodiesterase
K09K1_RS20530	COG2171	N-acyltransferase activity
K09K1_RS20545	COG3141	response to X-ray
K09K1_RS20570	COG0270	DNA (cytosine-5-)-methyltransferase activity
K09K1_RS20605	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
K09K1_RS20615	COG1074	ATP-dependent DNA helicase activity
K09K1_RS20620	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K09K1_RS20630	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
K09K1_RS20630	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K09K1_RS20645	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
K09K1_RS20650	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
K09K1_RS20655	COG2166	iron-sulfur cluster assembly
K09K1_RS20660	COG3706	GGDEF domain
K09K1_RS20665	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K09K1_RS20670	COG0693	protein deglycase activity
K09K1_RS20675	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K09K1_RS20700	COG1595	DNA-templated transcription, initiation
K09K1_RS20720	COG3056	Lipoprotein
K09K1_RS20725	COG2813	Specifically methylates the guanine in position
K09K1_RS20730	COG0271	Belongs to the BolA IbaG family
K09K1_RS20735	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K09K1_RS20740	COG1805	sodium ion transport
K09K1_RS20745	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K09K1_RS20750	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K09K1_RS20755	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K09K1_RS20760	COG2871	sodium ion transport
K09K1_RS20765	COG1477	protein flavinylation
K09K1_RS20785	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K09K1_RS20845	COG0519	Catalyzes the synthesis of GMP from XMP
K09K1_RS20850	COG0589	response to stress
K09K1_RS20855	COG0659	secondary active sulfate transmembrane transporter activity
K09K1_RS20890	COG3621	Patatin-like phospholipase
K09K1_RS20945	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K09K1_RS20970	COG0514	ATP-dependent DNA helicase (RecQ)
K09K1_RS20975	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K09K1_RS20990	COG0733	neurotransmitter:sodium symporter activity
K09K1_RS21010	COG0442	prolyl-tRNA aminoacylation
K09K1_RS21015	COG1720	tRNA m6t6A37 methyltransferase activity
K09K1_RS21020	COG0254	rRNA binding
K09K1_RS21030	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
K09K1_RS21055	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K09K1_RS21060	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K09K1_RS21095	COG3098	single-species biofilm formation
K09K1_RS21100	COG0564	pseudouridine synthase activity
K09K1_RS21110	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
K09K1_RS21115	COG0024	Methionine aminopeptidase
K09K1_RS21120	COG0052	Belongs to the universal ribosomal protein uS2 family
K09K1_RS21125	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K09K1_RS21130	COG0528	UMP kinase activity
K09K1_RS21135	COG0233	cytoplasmic translational termination
K09K1_RS21140	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K09K1_RS21145	COG0575	Belongs to the CDS family
K09K1_RS21150	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
K09K1_RS21155	COG0750	zinc metalloprotease
K09K1_RS21165	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
K09K1_RS21170	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K09K1_RS21180	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K09K1_RS21185	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K09K1_RS21195	COG0587	DNA-directed DNA polymerase activity
K09K1_RS21200	COG0825	malonyl-CoA metabolic process
K09K1_RS21215	COG0347	Belongs to the P(II) protein family
K09K1_RS21220	COG3021	interspecies interaction between organisms
K09K1_RS21230	COG0741	lytic transglycosylase activity
K09K1_RS21230	COG1388	LysM domain
K09K1_RS21235	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K09K1_RS21240	COG2226	methyltransferase
K09K1_RS21245	COG0328	RNA-DNA hybrid ribonuclease activity
K09K1_RS21280	COG1960	acyl-CoA dehydrogenase activity
K09K1_RS21285	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
K09K1_RS21290	COG0121	glutamine amidotransferase
K09K1_RS21295	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K09K1_RS21300	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K09K1_RS21305	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K09K1_RS21310	COG2233	PERMEase
K09K1_RS21330	COG1393	Belongs to the ArsC family
K09K1_RS21335	COG4783	chaperone-mediated protein folding
K09K1_RS21350	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K09K1_RS21370	COG1278	Cold shock
K09K1_RS21390	COG0330	HflC and HflK could
K09K1_RS21395	COG4974	Belongs to the 'phage' integrase family
K09K1_RS21400	COG1278	Cold shock
K09K1_RS21420	COG1278	Cold shock
K09K1_RS21430	COG0784	Response regulator, receiver
K09K1_RS21430	COG2205	protein histidine kinase activity
K09K1_RS21445	COG0210	DNA helicase
K09K1_RS21510	COG1053	succinate dehydrogenase
K09K1_RS21525	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K09K1_RS21550	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K09K1_RS21560	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K09K1_RS21565	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
K09K1_RS21580	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K09K1_RS21585	COG1393	Belongs to the ArsC family
K09K1_RS21610	COG2837	iron assimilation
K09K1_RS21615	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K09K1_RS21625	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K09K1_RS21630	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K09K1_RS21635	COG1334	flagellar protein FlaG
K09K1_RS21640	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
K09K1_RS21650	COG1516	flagellar protein fliS
K09K1_RS21670	COG1677	Flagellar hook-basal body complex protein FliE
K09K1_RS21680	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K09K1_RS21735	COG1987	bacterial-type flagellum assembly
K09K1_RS21740	COG1684	flagellar biosynthetic protein fliR
K09K1_RS21775	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
K09K1_RS21780	COG0643	Histidine kinase
K09K1_RS21780	COG0784	Response regulator, receiver
K09K1_RS21780	COG2198	Histidine kinase
K09K1_RS21785	COG2201	protein-glutamate methylesterase activity
K09K1_RS21790	COG1192	Involved in chromosome partitioning
K09K1_RS21800	COG0835	chemotaxis
K09K1_RS21810	COG4133	protoheme IX ABC transporter activity
K09K1_RS21815	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K09K1_RS21820	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K09K1_RS21825	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K09K1_RS21830	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
K09K1_RS21835	COG1138	Cytochrome C-type biogenesis protein
K09K1_RS21840	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K09K1_RS21850	COG4235	cytochrome complex assembly
K09K1_RS21850	COG3088	subunit of a heme lyase
K09K1_RS21860	COG2067	long-chain fatty acid transport protein
K09K1_RS21885	COG0183	Belongs to the thiolase family
K09K1_RS21890	COG1024	Enoyl-CoA hydratase
K09K1_RS21890	COG1250	3-hydroxyacyl-CoA dehydrogenase
K09K1_RS21905	COG2062	phosphohistidine phosphatase, SixA
K09K1_RS21910	COG2840	Smr protein MutS2
K09K1_RS21915	COG2890	protein-(glutamine-N5) methyltransferase activity
K09K1_RS21920	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K09K1_RS21925	COG2860	membrane
K09K1_RS21935	COG3101	peptidyl-lysine hydroxylation
K09K1_RS21950	COG0431	NADPH-dependent FMN reductase
K09K1_RS21955	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K09K1_RS21955	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
K09K1_RS21960	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K09K1_RS21970	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K09K1_RS21975	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K09K1_RS21985	COG0101	tRNA pseudouridine synthase activity
K09K1_RS21995	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K09K1_RS22000	COG0285	dihydrofolate synthase activity
K09K1_RS22005	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
K09K1_RS22010	COG1286	toxin biosynthetic process
K09K1_RS22015	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
K09K1_RS22020	COG0583	DNA-binding transcription factor activity
K09K1_RS22025	COG0745	RESPONSE REGULATOR receiver
K09K1_RS22035	COG2832	Protein of unknown function (DUF454)
K09K1_RS22040	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K09K1_RS22055	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K09K1_RS22060	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K09K1_RS22070	COG2261	transglycosylase associated protein
K09K1_RS22075	COG2983	Belongs to the UPF0260 family
K09K1_RS22080	COG0668	transmembrane transport
K09K1_RS22085	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
K09K1_RS22090	COG0346	lactoylglutathione lyase activity
K09K1_RS22100	COG1785	Belongs to the alkaline phosphatase family
K09K1_RS22115	COG2226	methyltransferase
K09K1_RS22130	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K09K1_RS22135	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K09K1_RS22145	COG3139	Protein of unknown function (DUF1315)
K09K1_RS22150	COG0252	asparaginase activity
K09K1_RS22155	COG0616	signal peptide processing
K09K1_RS22160	COG0446	pyridine nucleotide-disulphide oxidoreductase
K09K1_RS22160	COG1902	pentaerythritol trinitrate reductase activity
K09K1_RS22170	COG0778	Nitroreductase
K09K1_RS22175	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K09K1_RS22190	COG0123	including yeast histone deacetylase and acetoin utilization protein
K09K1_RS22205	COG3082	Protein of unknown function (DUF1414)
K09K1_RS22210	COG3081	Nucleoid-associated protein
K09K1_RS22225	COG1757	Na H antiporter
K09K1_RS22230	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K09K1_RS22235	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K09K1_RS22240	COG2095	MarC family integral membrane protein
K09K1_RS22245	COG1454	alcohol dehydrogenase
K09K1_RS22245	COG1012	belongs to the aldehyde dehydrogenase family
K09K1_RS22270	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
K09K1_RS22290	COG2056	Na+-H+ antiporter family
K09K1_RS22295	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K09K1_RS22300	COG2885	chlorophyll binding
K09K1_RS22310	COG0346	lactoylglutathione lyase activity
K09K1_RS22315	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K09K1_RS22320	COG4660	Part of a membrane complex involved in electron transport
K09K1_RS22325	COG4659	FMN binding
K09K1_RS22330	COG4658	electron transport chain
K09K1_RS22335	COG4656	Part of a membrane complex involved in electron transport
K09K1_RS22340	COG2878	Part of a membrane complex involved in electron transport
K09K1_RS22345	COG4657	Part of a membrane complex involved in electron transport
K09K1_RS22350	COG1882	Formate acetyltransferase
K09K1_RS22365	COG0556	nucleotide-excision repair
K09K1_RS22370	COG2204	response regulator
K09K1_RS22375	COG2198	Histidine kinase
K09K1_RS22380	COG0391	Required for morphogenesis under gluconeogenic growth conditions
K09K1_RS22385	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K09K1_RS22390	COG0521	Mo-molybdopterin cofactor biosynthetic process
K09K1_RS22395	COG0315	cyclic pyranopterin monophosphate synthase activity
K09K1_RS22400	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
K09K1_RS22405	COG0314	molybdopterin synthase activity
K09K1_RS22415	COG0601	transmembrane transport
K09K1_RS22420	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K09K1_RS22425	COG0444	Belongs to the ABC transporter superfamily
K09K1_RS22435	COG0435	Glutathione S-transferase
K09K1_RS22445	COG0857	belongs to the CobB CobQ family
K09K1_RS22445	COG0280	phosphate acetyltransferase
K09K1_RS22450	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K09K1_RS22455	COG3092	negative regulation of chromosome organization
K09K1_RS22465	COG4120	Belongs to the binding-protein-dependent transport system permease family
K09K1_RS22470	COG1122	ATPase activity
K09K1_RS22475	COG0366	Alpha amylase catalytic
K09K1_RS22480	COG3706	GGDEF domain
K09K1_RS22485	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K09K1_RS22490	COG3318	Belongs to the UPF0149 family
K09K1_RS22490	COG3012	SEC-C Motif Domain Protein
K09K1_RS22495	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
K09K1_RS22500	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K09K1_RS22505	COG2186	Transcriptional regulator
K09K1_RS22525	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K09K1_RS22525	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K09K1_RS22535	COG0572	uridine kinase
K09K1_RS22545	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
K09K1_RS22550	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K09K1_RS22555	COG0659	secondary active sulfate transmembrane transporter activity
K09K1_RS22565	COG1530	ribonuclease E activity
K09K1_RS22575	COG0564	pseudouridine synthase activity
K09K1_RS22580	COG0424	maF-like protein
K09K1_RS22585	COG1399	metal-binding, possibly nucleic acid-binding protein
K09K1_RS22595	COG0416	fatty acid biosynthetic process
K09K1_RS22600	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K09K1_RS22630	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K09K1_RS22635	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K09K1_RS22640	COG0470	DNA polymerase III
K09K1_RS22645	COG0084	hydrolase, TatD family'
K09K1_RS22650	COG1263	PTS System
K09K1_RS22650	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K09K1_RS22665	COG0733	neurotransmitter:sodium symporter activity
K09K1_RS22680	COG4667	esterase of the alpha-beta hydrolase superfamily
K09K1_RS22685	COG0469	pyruvate kinase activity
K09K1_RS22690	COG1940	carbohydrate kinase activity
K09K1_RS22695	COG0784	Response regulator, receiver
K09K1_RS22695	COG0835	chemotaxis
K09K1_RS22700	COG0587	DNA-directed DNA polymerase activity
K09K1_RS22715	COG1028	Short-chain dehydrogenase reductase Sdr
K09K1_RS22720	COG0616	signal peptide processing
K09K1_RS22725	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K09K1_RS22730	COG0539	negative regulation of cytoplasmic translation
K09K1_RS22740	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
K09K1_RS22745	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
K09K1_RS22755	COG4166	transmembrane transport
K09K1_RS22775	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K09K1_RS22775	COG3008	intermembrane lipid transfer
K09K1_RS22780	COG2995	paraquat-inducible protein a
K09K1_RS22785	COG3258	Cytochrome c
K09K1_RS22790	COG2863	cytochrome
K09K1_RS22825	COG4232	protein-disulfide reductase activity
K09K1_RS22830	COG3118	belongs to the thioredoxin family
K09K1_RS22855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K09K1_RS22865	COG1136	(ABC) transporter
K09K1_RS22865	COG0577	efflux transmembrane transporter activity
K09K1_RS22870	COG0577	efflux transmembrane transporter activity
K09K1_RS22870	COG1136	(ABC) transporter
K09K1_RS22875	COG1136	(ABC) transporter
K09K1_RS22875	COG0577	efflux transmembrane transporter activity
K09K1_RS22925	COG5002	protein histidine kinase activity
K09K1_RS22925	COG3850	Histidine kinase
K09K1_RS22930	COG0745	RESPONSE REGULATOR receiver
K09K1_RS22935	COG0463	Glycosyl transferase, family 2
K09K1_RS22940	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
K09K1_RS22960	COG1032	radical SAM domain protein
K09K1_RS22965	COG5001	Diguanylate cyclase
K09K1_RS22980	COG0583	DNA-binding transcription factor activity
K09K1_RS22985	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
K09K1_RS22995	COG2350	Protein conserved in bacteria
K09K1_RS23005	COG2917	probably involved in intracellular septation
K09K1_RS23025	COG1301	dicarboxylic acid transport
K09K1_RS23035	COG0318	PFAM AMP-dependent synthetase and ligase
K09K1_RS23040	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K09K1_RS23045	COG0159	tryptophan synthase activity
K09K1_RS23055	COG0135	phosphoribosylanthranilate isomerase activity
K09K1_RS23055	COG0134	indole-3-glycerol-phosphate synthase activity
K09K1_RS23065	COG0512	Glutamine amidotransferase of anthranilate synthase
K09K1_RS23070	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K09K1_RS23080	COG0613	PHP domain protein
K09K1_RS23085	COG0009	L-threonylcarbamoyladenylate synthase
K09K1_RS23095	COG1187	pseudouridine synthase activity
K09K1_RS23115	COG0417	DNA replication proofreading
K09K1_RS23120	COG2197	response regulator
K09K1_RS23125	COG0322	excinuclease ABC activity
K09K1_RS23170	COG0019	diaminopimelate decarboxylase activity
K09K1_RS23200	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K09K1_RS23205	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K09K1_RS23225	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
K09K1_RS23235	COG0437	4 iron, 4 sulfur cluster binding
K09K1_RS23240	COG3301	Polysulphide reductase, NrfD
K09K1_RS23245	COG1138	Cytochrome C-type biogenesis protein
K09K1_RS23255	COG3088	subunit of a heme lyase
K09K1_RS23255	COG4235	cytochrome complex assembly
K09K1_RS23265	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K09K1_RS23290	COG2989	Protein conserved in bacteria
K09K1_RS23295	COG3108	Peptidase M15
K09K1_RS23300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K09K1_RS23315	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
K09K1_RS23345	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K09K1_RS23350	COG0840	transmembrane signaling receptor activity
K09K1_RS23370	COG1448	Aminotransferase
K09K1_RS23385	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K09K1_RS23395	COG0017	Asparaginyl-tRNA synthetase
K09K1_RS23400	COG0840	transmembrane signaling receptor activity
K09K1_RS23405	COG0720	synthase
K09K1_RS23415	COG2200	EAL domain
K09K1_RS23420	COG1760	l-serine dehydratase
K09K1_RS23425	COG0814	amino acid
K09K1_RS23430	COG0494	nUDIX hydrolase
K09K1_RS23440	COG2205	protein histidine kinase activity
K09K1_RS23440	COG0784	Response regulator, receiver
K09K1_RS23445	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K09K1_RS23460	COG3106	COG3106 Predicted ATPase
K09K1_RS23465	COG3768	UPF0283 membrane protein
K09K1_RS23475	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K09K1_RS23525	COG4628	conserved protein (DUF2132)
K09K1_RS23635	COG1335	isochorismatase
K09K1_RS23710	COG2197	response regulator
K09K1_RS23715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K09K1_RS23715	COG2205	protein histidine kinase activity
K09K1_RS23725	COG1472	Belongs to the glycosyl hydrolase 3 family
K09K1_RS23795	COG2197	response regulator
K09K1_RS23800	COG2199	diguanylate cyclase activity
K09K1_RS23800	COG3287	FIST C domain
K09K1_RS23800	COG2200	EAL domain
K09K1_RS23805	COG3477	response to acidic pH
K09K1_RS23880	COG2205	protein histidine kinase activity
K09K1_RS23880	COG0784	Response regulator, receiver
K09K1_RS23885	COG2221	Nitrite and sulphite reductase 4Fe-4S
K09K1_RS23885	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K09K1_RS23895	COG0243	molybdopterin cofactor binding
K09K1_RS23900	COG0437	4 iron, 4 sulfur cluster binding
K09K1_RS23905	COG3302	dmso reductase anchor subunit
K09K1_RS23930	COG0025	NhaP-type Na H and K H
K09K1_RS23935	COG2985	domain, Protein
K09K1_RS23945	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
K09K1_RS23960	COG1289	transmembrane transporter activity
K09K1_RS23975	COG0387	Pfam Sodium calcium exchanger
K09K1_RS23980	COG0387	Pfam Sodium calcium exchanger
K09K1_RS23990	COG0598	Magnesium transport protein CorA
K09K1_RS23995	COG2963	transposase activity
K09K1_RS24000	COG0076	glutamate decarboxylase activity
K09K1_RS24005	COG2985	domain, Protein
K09K1_RS24020	COG3706	GGDEF domain
K09K1_RS24030	COG4974	Belongs to the 'phage' integrase family
K09K1_RS24120	COG1403	HNH endonuclease
K09K1_RS24155	COG2801	Transposase and inactivated derivatives
K09K1_RS24240	COG1683	Conserved Protein
K09K1_RS24270	COG2801	Transposase and inactivated derivatives
K09K1_RS24320	COG0110	maltose O-acetyltransferase activity
K09K1_RS24330	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K09K1_RS24350	COG5507	3-demethylubiquinone-9 3-methyltransferase
K09K1_RS24355	COG1280	lysine exporter protein (LysE YggA)
K09K1_RS24360	COG1280	lysine exporter protein (LysE YggA)
K09K1_RS24370	COG0729	surface antigen
K09K1_RS24380	COG2272	Belongs to the type-B carboxylesterase lipase family
K09K1_RS24405	COG2985	domain, Protein
K09K1_RS24415	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
K09K1_RS24430	COG0583	DNA-binding transcription factor activity
K09K1_RS24445	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K09K1_RS24460	COG3290	protein histidine kinase activity
K09K1_RS24465	COG4565	transcriptional regulatory protein
K09K1_RS24475	COG2207	Transcriptional regulator
K09K1_RS24480	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K09K1_RS24485	COG0363	glucosamine-6-phosphate deaminase activity
K09K1_RS24490	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
K09K1_RS24505	COG3284	Transcriptional regulator
K09K1_RS24510	COG1012	belongs to the aldehyde dehydrogenase family
K09K1_RS24580	COG4669	(LipO)protein
K09K1_RS24600	COG3177	Filamentation induced by cAMP protein fic
K09K1_RS24630	COG2207	Transcriptional regulator
K09K1_RS24635	COG4792	protein secretion
K09K1_RS24640	COG4791	protein targeting
K09K1_RS24645	COG4794	Type iii secretion
K09K1_RS24650	COG4790	Type iii secretion
K09K1_RS24720	COG0457	Tetratricopeptide repeat
K09K1_RS24735	COG2358	TRAP transporter, solute receptor (TAXI family
K09K1_RS24740	COG0730	response to heat
K09K1_RS24775	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
K09K1_RS24780	COG0372	Belongs to the citrate synthase family
K09K1_RS24790	COG2828	Protein conserved in bacteria
K09K1_RS24815	COG0561	phosphatase activity
K09K1_RS24820	COG0602	queuosine metabolic process
K09K1_RS24825	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
K09K1_RS24840	COG0583	DNA-binding transcription factor activity
K09K1_RS24850	COG0583	DNA-binding transcription factor activity
K09K1_RS24865	COG0583	DNA-binding transcription factor activity
K09K1_RS24880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K09K1_RS24885	COG0765	amino acid transport
K09K1_RS24890	COG1126	abc transporter atp-binding protein
K09K1_RS24895	COG1410	methionine synthase
K09K1_RS24895	COG0646	methionine synthase
K09K1_RS24910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K09K1_RS24915	COG1335	isochorismatase
K09K1_RS24935	COG2814	Major facilitator Superfamily
K09K1_RS24940	COG0583	DNA-binding transcription factor activity
K09K1_RS24950	COG0583	DNA-binding transcription factor activity
K09K1_RS24955	COG0656	L-ascorbic acid biosynthetic process
K09K1_RS24965	COG1414	Transcriptional regulator
K09K1_RS24970	COG2199	diguanylate cyclase activity
K09K1_RS24970	COG2203	Gaf domain
K09K1_RS24995	COG2885	chlorophyll binding
K09K1_RS25015	COG0840	transmembrane signaling receptor activity
K09K1_RS25020	COG1254	Belongs to the acylphosphatase family
K09K1_RS25025	COG2920	part of a sulfur-relay system
K09K1_RS25040	COG0670	Belongs to the BI1 family
K09K1_RS25045	COG1126	abc transporter atp-binding protein
K09K1_RS25050	COG0765	amino acid transport
K09K1_RS25055	COG4597	amino acid ABC transporter
K09K1_RS25060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K09K1_RS25075	COG1666	GTP binding
K09K1_RS25080	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K09K1_RS25105	COG3008	intermembrane lipid transfer
K09K1_RS25110	COG2995	paraquat-inducible protein a
K09K1_RS25115	COG1132	(ABC) transporter
K09K1_RS25120	COG1956	GAF domain-containing protein
K09K1_RS25125	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
K09K1_RS25140	COG0308	aminopeptidase N
K09K1_RS25150	COG2902	Dehydrogenase
K09K1_RS25155	COG0167	dihydroorotate dehydrogenase activity
K09K1_RS25165	COG0116	Belongs to the methyltransferase superfamily
K09K1_RS25165	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K09K1_RS25175	COG0488	(ABC) transporter
K09K1_RS25190	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K09K1_RS25200	COG3120	sequence-specific DNA binding
K09K1_RS25230	COG4128	Pfam Zonular occludens toxin