locus-tag	class	description
K10K4_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K10K4_RS00010	COG0592	DNA-directed DNA polymerase activity
K10K4_RS00020	COG0187	DNA topoisomerase II activity
K10K4_RS00035	COG0071	Belongs to the small heat shock protein (HSP20) family
K10K4_RS00040	COG3977	Valine--pyruvate aminotransferase
K10K4_RS00045	COG0366	Alpha amylase catalytic
K10K4_RS00060	COG2119	membrane
K10K4_RS00070	COG0425	Belongs to the sulfur carrier protein TusA family
K10K4_RS00085	COG0604	alcohol dehydrogenase
K10K4_RS00090	COG0183	Belongs to the thiolase family
K10K4_RS00100	COG1739	Uncharacterized protein family UPF0029
K10K4_RS00105	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K10K4_RS00145	COG0583	DNA-binding transcription factor activity
K10K4_RS00150	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K10K4_RS00155	COG2960	long-chain fatty acid transporting porin activity
K10K4_RS00165	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K10K4_RS00170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K10K4_RS00230	COG4166	transmembrane transport
K10K4_RS00235	COG0601	transmembrane transport
K10K4_RS00240	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K10K4_RS00250	COG1609	Transcriptional regulator
K10K4_RS00255	COG0583	DNA-binding transcription factor activity
K10K4_RS00270	COG0129	dihydroxy-acid dehydratase activity
K10K4_RS00275	COG3265	gluconokinase activity
K10K4_RS00280	COG2610	gluconate transmembrane transporter activity
K10K4_RS00285	COG0800	Aldolase
K10K4_RS00290	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
K10K4_RS00295	COG0583	DNA-binding transcription factor activity
K10K4_RS00300	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K10K4_RS00305	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
K10K4_RS00315	COG1522	sequence-specific DNA binding
K10K4_RS00320	COG5001	Diguanylate cyclase
K10K4_RS00320	COG5002	protein histidine kinase activity
K10K4_RS00325	COG0742	ribosomal rna small subunit methyltransferase
K10K4_RS00340	COG0589	response to stress
K10K4_RS00345	COG1528	Iron-storage protein
K10K4_RS00355	COG2081	HI0933 family
K10K4_RS00385	COG1597	lipid kinase activity
K10K4_RS00415	COG0628	permease
K10K4_RS00430	COG1322	Protein conserved in bacteria
K10K4_RS00435	COG2226	methyltransferase
K10K4_RS00440	COG3165	ubiquinone biosynthetic process from chorismate
K10K4_RS00445	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K10K4_RS00455	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K10K4_RS00460	COG0805	protein transport
K10K4_RS00470	COG0084	hydrolase, TatD family'
K10K4_RS00485	COG0456	acetyltransferase
K10K4_RS00495	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K10K4_RS00495	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K10K4_RS00500	COG0218	Necessary for normal cell division and for the maintenance of normal septation
K10K4_RS00535	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K10K4_RS00545	COG2204	response regulator
K10K4_RS00550	COG3852	Histidine kinase
K10K4_RS00560	COG0174	glutamine synthetase
K10K4_RS00565	COG1217	gtp-binding protein TYPA
K10K4_RS00570	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K10K4_RS00580	COG1295	ribonuclease BN
K10K4_RS00585	COG1490	D-aminoacyl-tRNA deacylase activity
K10K4_RS00590	COG0456	acetyltransferase
K10K4_RS00600	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
K10K4_RS00605	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
K10K4_RS00610	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
K10K4_RS00615	COG3031	protein transport across the cell outer membrane
K10K4_RS00625	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K10K4_RS00630	COG1459	type II secretion system
K10K4_RS00635	COG2165	general secretion pathway protein
K10K4_RS00640	COG2165	general secretion pathway protein
K10K4_RS00645	COG2165	general secretion pathway protein
K10K4_RS00650	COG4795	General secretion pathway protein
K10K4_RS00655	COG3156	type II secretion system protein K
K10K4_RS00660	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
K10K4_RS00665	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
K10K4_RS00675	COG1218	3'(2'),5'-bisphosphate nucleotidase
K10K4_RS00680	COG0494	nUDIX hydrolase
K10K4_RS00690	COG1040	competence protein
K10K4_RS00705	COG2183	response to ionizing radiation
K10K4_RS00715	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K10K4_RS00735	COG2233	PERMEase
K10K4_RS00740	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K10K4_RS00745	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K10K4_RS00750	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K10K4_RS00755	COG1758	RNA polymerase activity
K10K4_RS00760	COG0194	GDP metabolic process
K10K4_RS00775	COG0848	biopolymer transport protein
K10K4_RS00780	COG0811	peptide transport
K10K4_RS00805	COG4174	ABC transporter (Permease)
K10K4_RS00810	COG4239	(ABC) transporter, permease
K10K4_RS00815	COG0747	negative chemotaxis
K10K4_RS00820	COG0444	Belongs to the ABC transporter superfamily
K10K4_RS00825	COG4608	Belongs to the ABC transporter superfamily
K10K4_RS00835	COG1561	YicC-like family, N-terminal region
K10K4_RS00845	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
K10K4_RS00850	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K10K4_RS00855	COG1560	Kdo2-lipid A biosynthetic process
K10K4_RS00860	COG1309	transcriptional regulator
K10K4_RS00865	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K10K4_RS00875	COG2003	Belongs to the UPF0758 family
K10K4_RS00900	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K10K4_RS00915	COG0463	Glycosyl transferase, family 2
K10K4_RS00920	COG0859	PFAM glycosyl transferase family 9
K10K4_RS00925	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K10K4_RS00930	COG3642	lipopolysaccharide core region biosynthetic process
K10K4_RS00940	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
K10K4_RS00980	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K10K4_RS00985	COG1519	Transferase
K10K4_RS00990	COG0859	PFAM glycosyl transferase family 9
K10K4_RS01000	COG1560	Kdo2-lipid A biosynthetic process
K10K4_RS01020	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K10K4_RS01070	COG0438	transferase activity, transferring glycosyl groups
K10K4_RS01080	COG0297	glycogen (starch) synthase activity
K10K4_RS01080	COG0438	transferase activity, transferring glycosyl groups
K10K4_RS01090	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K10K4_RS01095	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
K10K4_RS01100	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K10K4_RS01130	COG1215	transferase activity, transferring glycosyl groups
K10K4_RS01155	COG0149	triose-phosphate isomerase activity
K10K4_RS01185	COG1494	fructose-1,6-bisphosphatase
K10K4_RS01195	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K10K4_RS01200	COG1575	Belongs to the MenA family. Type 1 subfamily
K10K4_RS01230	COG2003	Belongs to the UPF0758 family
K10K4_RS01245	COG4565	transcriptional regulatory protein
K10K4_RS01255	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
K10K4_RS01260	COG0511	ligase activity, forming carbon-carbon bonds
K10K4_RS01260	COG5016	pyruvate
K10K4_RS01265	COG3630	sodium ion export across plasma membrane
K10K4_RS01275	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
K10K4_RS01285	COG2301	Belongs to the HpcH HpaI aldolase family
K10K4_RS01290	COG3051	citrate lyase alpha subunit
K10K4_RS01300	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
K10K4_RS01315	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K10K4_RS01320	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
K10K4_RS01330	COG1609	Transcriptional regulator
K10K4_RS01335	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K10K4_RS01345	COG0254	rRNA binding
K10K4_RS01355	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K10K4_RS01360	COG0088	Forms part of the polypeptide exit tunnel
K10K4_RS01370	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K10K4_RS01375	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K10K4_RS01380	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K10K4_RS01385	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K10K4_RS01395	COG0255	Belongs to the universal ribosomal protein uL29 family
K10K4_RS01400	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K10K4_RS01410	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K10K4_RS01415	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K10K4_RS01420	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K10K4_RS01425	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K10K4_RS01430	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K10K4_RS01445	COG1841	ribosomal large subunit assembly
K10K4_RS01450	COG0200	Binds to the 23S rRNA
K10K4_RS01455	COG0201	protein transport
K10K4_RS01460	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K10K4_RS01465	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K10K4_RS01470	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K10K4_RS01480	COG0202	RNA polymerase activity
K10K4_RS01485	COG0203	ribosomal protein L17
K10K4_RS01495	COG0545	Peptidyl-prolyl cis-trans isomerase
K10K4_RS01505	COG2153	protein acetylation
K10K4_RS01510	COG0513	Belongs to the DEAD box helicase family
K10K4_RS01525	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K10K4_RS01525	COG1648	precorrin-2 dehydrogenase activity
K10K4_RS01530	COG0175	sulfate reduction
K10K4_RS01535	COG2895	sulfate adenylyltransferase (ATP) activity
K10K4_RS01540	COG0471	metal ion transport
K10K4_RS01540	COG3273	potassium ion transport
K10K4_RS01545	COG0529	Catalyzes the synthesis of activated sulfate
K10K4_RS01565	COG4181	ATPase activity
K10K4_RS01580	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
K10K4_RS01590	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K10K4_RS01595	COG0729	surface antigen
K10K4_RS01600	COG2911	Protein conserved in bacteria
K10K4_RS01605	COG2105	PFAM AIG2 family protein
K10K4_RS01615	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
K10K4_RS01620	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
K10K4_RS01625	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K10K4_RS01630	COG0163	prenyltransferase activity
K10K4_RS01635	COG4143	(ABC) transporter
K10K4_RS01640	COG1178	ABC-type Fe3 transport system permease component
K10K4_RS01645	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
K10K4_RS01650	COG0583	DNA-binding transcription factor activity
K10K4_RS01655	COG1902	pentaerythritol trinitrate reductase activity
K10K4_RS01675	COG2358	TRAP transporter, solute receptor (TAXI family
K10K4_RS01700	COG0142	geranyltranstransferase activity
K10K4_RS01705	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K10K4_RS01715	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K10K4_RS01720	COG2966	Psort location CytoplasmicMembrane, score
K10K4_RS01730	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
K10K4_RS01735	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
K10K4_RS01740	COG2967	ApaG domain
K10K4_RS01745	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K10K4_RS01750	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
K10K4_RS01755	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K10K4_RS01760	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
K10K4_RS01765	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
K10K4_RS01785	COG0473	3-isopropylmalate dehydrogenase activity
K10K4_RS01790	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K10K4_RS01815	COG0583	DNA-binding transcription factor activity
K10K4_RS01820	COG1022	Amp-dependent synthetase and ligase
K10K4_RS01825	COG0028	Belongs to the TPP enzyme family
K10K4_RS01830	COG0440	acetolactate synthase activity
K10K4_RS01845	COG0469	pyruvate kinase activity
K10K4_RS01850	COG1349	DNA-binding transcription factor activity
K10K4_RS01855	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K10K4_RS01865	COG2376	Dihydroxyacetone kinase
K10K4_RS01870	COG1461	Dihydroxyacetone kinase
K10K4_RS01885	COG3722	fumarate hydratase activity
K10K4_RS01895	COG2213	PTS system mannitol-specific
K10K4_RS01895	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K10K4_RS01930	COG0358	DNA primase activity
K10K4_RS01935	COG1610	YqeY-like protein
K10K4_RS01940	COG0828	Belongs to the bacterial ribosomal protein bS21 family
K10K4_RS01945	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K10K4_RS01950	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K10K4_RS01955	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
K10K4_RS01960	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
K10K4_RS01965	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K10K4_RS01970	COG1968	undecaprenyl-diphosphatase activity
K10K4_RS01980	COG3409	Peptidoglycan-binding domain 1 protein
K10K4_RS01980	COG3267	Type II secretory pathway component ExeA
K10K4_RS01990	COG0405	Gamma-glutamyltransferase
K10K4_RS01995	COG4991	sh3 domain protein
K10K4_RS02000	COG0306	phosphate transporter
K10K4_RS02005	COG1392	Phosphate transport regulator
K10K4_RS02010	COG3025	triphosphatase activity
K10K4_RS02025	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
K10K4_RS02030	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
K10K4_RS02030	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
K10K4_RS02035	COG1538	Outer membrane efflux protein
K10K4_RS02040	COG0494	nUDIX hydrolase
K10K4_RS02045	COG3151	Protein conserved in bacteria
K10K4_RS02055	COG3150	esterase
K10K4_RS02065	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K10K4_RS02070	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K10K4_RS02080	COG3105	Protein conserved in bacteria
K10K4_RS02085	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
K10K4_RS02100	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K10K4_RS02105	COG0723	plastoquinol--plastocyanin reductase activity
K10K4_RS02110	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K10K4_RS02115	COG2857	Cytochrome c1
K10K4_RS02120	COG0625	glutathione transferase activity
K10K4_RS02125	COG2969	positive regulation of protein catabolic process
K10K4_RS02135	COG2823	Periplasmic or secreted lipoprotein
K10K4_RS02140	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
K10K4_RS02155	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
K10K4_RS02175	COG3116	cell division
K10K4_RS02180	COG0768	penicillin binding
K10K4_RS02185	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K10K4_RS02190	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K10K4_RS02195	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K10K4_RS02200	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K10K4_RS02205	COG0772	Belongs to the SEDS family
K10K4_RS02220	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K10K4_RS02225	COG0849	cell division
K10K4_RS02230	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K10K4_RS02235	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
K10K4_RS02245	COG0653	protein targeting
K10K4_RS02250	COG0494	nUDIX hydrolase
K10K4_RS02260	COG0505	Belongs to the CarA family
K10K4_RS02265	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K10K4_RS02280	COG0730	response to heat
K10K4_RS02285	COG0583	DNA-binding transcription factor activity
K10K4_RS02290	COG2860	membrane
K10K4_RS02305	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K10K4_RS02315	COG0493	'glutamate synthase
K10K4_RS02320	COG0069	glutamate synthase activity
K10K4_RS02320	COG0067	glutamate synthase
K10K4_RS02320	COG0070	glutamate synthase
K10K4_RS02330	COG0069	glutamate synthase activity
K10K4_RS02330	COG0067	glutamate synthase
K10K4_RS02330	COG0070	glutamate synthase
K10K4_RS02335	COG1242	4 iron, 4 sulfur cluster binding
K10K4_RS02340	COG5001	Diguanylate cyclase
K10K4_RS02340	COG2203	Gaf domain
K10K4_RS02340	COG3706	GGDEF domain
K10K4_RS02340	COG4251	negative regulation of phosphorylation
K10K4_RS02345	COG2198	Histidine kinase
K10K4_RS02345	COG5002	protein histidine kinase activity
K10K4_RS02345	COG0784	Response regulator, receiver
K10K4_RS02355	COG0745	RESPONSE REGULATOR receiver
K10K4_RS02370	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K10K4_RS02390	COG0083	homoserine kinase activity
K10K4_RS02395	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
K10K4_RS02405	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
K10K4_RS02410	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
K10K4_RS02420	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K10K4_RS02435	COG1115	amino acid carrier protein
K10K4_RS02440	COG3022	response to hydroperoxide
K10K4_RS02445	COG0513	Belongs to the DEAD box helicase family
K10K4_RS02450	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
K10K4_RS02460	COG0716	FMN binding
K10K4_RS02465	COG4974	Belongs to the 'phage' integrase family
K10K4_RS02470	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K10K4_RS02475	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K10K4_RS02490	COG2204	response regulator
K10K4_RS02500	COG0667	Aldo Keto reductase
K10K4_RS02525	COG0730	response to heat
K10K4_RS02530	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K10K4_RS02535	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
K10K4_RS02545	COG1283	sodium-dependent phosphate transmembrane transporter activity
K10K4_RS02550	COG0583	DNA-binding transcription factor activity
K10K4_RS02555	COG0640	Transcriptional regulator
K10K4_RS02560	COG0268	Binds directly to 16S ribosomal RNA
K10K4_RS02565	COG0728	peptidoglycan biosynthetic process
K10K4_RS02570	COG0196	riboflavin kinase activity
K10K4_RS02585	COG1047	Peptidyl-prolyl cis-trans
K10K4_RS02590	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K10K4_RS02600	COG3279	Response regulator of the LytR AlgR family
K10K4_RS02605	COG3275	phosphorelay sensor kinase activity
K10K4_RS02610	COG1966	Carbon starvation protein
K10K4_RS02630	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
K10K4_RS02635	COG1472	Belongs to the glycosyl hydrolase 3 family
K10K4_RS02640	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K10K4_RS02645	COG1605	Chorismate mutase
K10K4_RS02645	COG0287	Prephenate dehydrogenase
K10K4_RS02650	COG0739	heme binding
K10K4_RS02660	COG0488	(ABC) transporter
K10K4_RS02670	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
K10K4_RS02675	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
K10K4_RS02680	COG0077	Prephenate dehydratase
K10K4_RS02680	COG1605	Chorismate mutase
K10K4_RS02685	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K10K4_RS02695	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K10K4_RS02700	COG0564	pseudouridine synthase activity
K10K4_RS02710	COG0542	response to heat
K10K4_RS02775	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K10K4_RS02780	COG0826	peptidase U32
K10K4_RS02785	COG2974	May be involved in recombination
K10K4_RS02795	COG0745	RESPONSE REGULATOR receiver
K10K4_RS02800	COG5002	protein histidine kinase activity
K10K4_RS02810	COG0248	Ppx GppA phosphatase
K10K4_RS02815	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
K10K4_RS02820	COG0573	inorganic phosphate transmembrane transporter activity
K10K4_RS02825	COG0581	inorganic phosphate transmembrane transporter activity
K10K4_RS02830	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K10K4_RS02835	COG0704	Plays a role in the regulation of phosphate uptake
K10K4_RS02845	COG3142	Participates in the control of copper homeostasis
K10K4_RS02850	COG0450	alkyl hydroperoxide reductase
K10K4_RS02855	COG0583	DNA-binding transcription factor activity
K10K4_RS02860	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
K10K4_RS02870	COG0517	IMP dehydrogenase activity
K10K4_RS02880	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K10K4_RS02890	COG1862	Preprotein translocase
K10K4_RS02895	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K10K4_RS02900	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K10K4_RS02915	COG0483	inositol monophosphate 1-phosphatase activity
K10K4_RS02920	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
K10K4_RS02930	COG1104	cysteine desulfurase activity
K10K4_RS02935	COG0822	iron-sulfur transferase activity
K10K4_RS02950	COG0443	Heat shock 70 kDa protein
K10K4_RS02955	COG0633	Ferredoxin
K10K4_RS02960	COG2975	iron-sulfur cluster assembly
K10K4_RS02970	COG0105	UTP biosynthetic process
K10K4_RS02985	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K10K4_RS02990	COG0124	histidyl-tRNA synthetase
K10K4_RS02995	COG2976	Protein conserved in bacteria
K10K4_RS03000	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K10K4_RS03005	COG1160	GTP binding
K10K4_RS03025	COG0517	IMP dehydrogenase activity
K10K4_RS03025	COG0516	GMP reductase activity
K10K4_RS03035	COG0582	viral genome integration into host DNA
K10K4_RS03100	COG1757	Na H antiporter
K10K4_RS03110	COG1584	GPR1 FUN34 yaaH family protein
K10K4_RS03115	COG1115	amino acid carrier protein
K10K4_RS03130	COG2873	o-acetylhomoserine
K10K4_RS03135	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K10K4_RS03155	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K10K4_RS03155	COG3153	acetyltransferase
K10K4_RS03160	COG0583	DNA-binding transcription factor activity
K10K4_RS03185	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K10K4_RS03190	COG2867	negative regulation of translational initiation
K10K4_RS03195	COG2914	Belongs to the UPF0125 (RnfH) family
K10K4_RS03200	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K10K4_RS03210	COG0497	DNA recombination
K10K4_RS03220	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K10K4_RS03225	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K10K4_RS03230	COG1301	dicarboxylic acid transport
K10K4_RS03240	COG0484	heat shock protein binding
K10K4_RS03275	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
K10K4_RS03290	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
K10K4_RS03295	COG0047	phosphoribosylformylglycinamidine synthase activity
K10K4_RS03295	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K10K4_RS03325	COG2195	Cleaves the N-terminal amino acid of tripeptides
K10K4_RS03330	COG2252	PERMEase
K10K4_RS03335	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
K10K4_RS03340	COG1073	alpha beta
K10K4_RS03350	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K10K4_RS03355	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K10K4_RS03360	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K10K4_RS03365	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K10K4_RS03365	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K10K4_RS03380	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
K10K4_RS03390	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
K10K4_RS03395	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
K10K4_RS03400	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K10K4_RS03405	COG0142	geranyltranstransferase activity
K10K4_RS03410	COG1722	exodeoxyribonuclease VII activity
K10K4_RS03415	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K10K4_RS03425	COG0301	tRNA thio-modification
K10K4_RS03425	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K10K4_RS03430	COG0583	DNA-binding transcription factor activity
K10K4_RS03440	COG2363	Small membrane protein
K10K4_RS03450	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K10K4_RS03455	COG1611	Belongs to the LOG family
K10K4_RS03470	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K10K4_RS03470	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K10K4_RS03480	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
K10K4_RS03485	COG1464	Belongs to the NlpA lipoprotein family
K10K4_RS03490	COG2011	ABC-type metal ion transport system permease component
K10K4_RS03495	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K10K4_RS03500	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
K10K4_RS03510	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K10K4_RS03510	COG1263	PTS System
K10K4_RS03515	COG0366	Alpha amylase catalytic
K10K4_RS03530	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K10K4_RS03535	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K10K4_RS03540	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K10K4_RS03545	COG0321	lipoyl(octanoyl) transferase activity
K10K4_RS03555	COG1686	Belongs to the peptidase S11 family
K10K4_RS03560	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
K10K4_RS03565	COG0772	Belongs to the SEDS family
K10K4_RS03570	COG0768	penicillin binding
K10K4_RS03575	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K10K4_RS03580	COG0799	negative regulation of ribosome biogenesis
K10K4_RS03585	COG1466	dna polymerase III delta subunit
K10K4_RS03590	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
K10K4_RS03595	COG0495	leucyl-tRNA aminoacylation
K10K4_RS03600	COG2888	peptidyl-tyrosine sulfation
K10K4_RS03605	COG0815	Transfers the fatty acyl group on membrane lipoproteins
K10K4_RS03610	COG4535	Mg2 and Co2 transporter CorC
K10K4_RS03615	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K10K4_RS03620	COG1702	phosphate starvation-inducible protein PhoH
K10K4_RS03625	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K10K4_RS03630	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K10K4_RS03740	COG0012	GTP binding
K10K4_RS03745	COG0193	aminoacyl-tRNA hydrolase activity
K10K4_RS03750	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K10K4_RS03755	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K10K4_RS03760	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
K10K4_RS03765	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
K10K4_RS03775	COG2890	protein-(glutamine-N5) methyltransferase activity
K10K4_RS03780	COG3094	Invasion gene expression up-regulator, SirB
K10K4_RS03785	COG2912	Transglutaminase-like superfamily
K10K4_RS03790	COG2877	3-deoxy-8-phosphooctulonate synthase activity
K10K4_RS03795	COG0737	Belongs to the 5'-nucleotidase family
K10K4_RS03800	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K10K4_RS03805	COG1187	pseudouridine synthase activity
K10K4_RS03810	COG2840	Smr protein MutS2
K10K4_RS03850	COG2217	Heavy metal translocating P-type atpase
K10K4_RS03850	COG2608	mercury ion transmembrane transporter activity
K10K4_RS03865	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
K10K4_RS03920	COG0835	chemotaxis
K10K4_RS03920	COG0784	Response regulator, receiver
K10K4_RS03925	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
K10K4_RS03930	COG1815	bacterial-type flagellum-dependent cell motility
K10K4_RS03935	COG1558	bacterial-type flagellum-dependent cell motility
K10K4_RS03945	COG1749	Flagellar hook protein flgE
K10K4_RS03950	COG4787	bacterial-type flagellum-dependent cell motility
K10K4_RS03960	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
K10K4_RS03965	COG1706	bacterial-type flagellum-dependent cell motility
K10K4_RS03970	COG1705	Flagellar rod assembly protein muramidase FlgJ
K10K4_RS03970	COG3951	Flagellar rod assembly protein muramidase FlgJ
K10K4_RS03980	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K10K4_RS03985	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K10K4_RS03995	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K10K4_RS04000	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K10K4_RS04005	COG2190	(PTS) system
K10K4_RS04010	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K10K4_RS04015	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K10K4_RS04025	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K10K4_RS04030	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
K10K4_RS04035	COG3115	cell septum assembly
K10K4_RS04040	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K10K4_RS04065	COG0330	HflC and HflK could
K10K4_RS04070	COG2194	sulfuric ester hydrolase activity
K10K4_RS04085	COG1192	Involved in chromosome partitioning
K10K4_RS04090	COG1215	transferase activity, transferring glycosyl groups
K10K4_RS04100	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
K10K4_RS04105	COG3118	belongs to the thioredoxin family
K10K4_RS04105	COG0457	Tetratricopeptide repeat
K10K4_RS04110	COG3118	belongs to the thioredoxin family
K10K4_RS04115	COG0300	oxidoreductase activity
K10K4_RS04120	COG1090	epimerase
K10K4_RS04150	COG0622	Phosphoesterase
K10K4_RS04170	COG3710	Transcriptional regulator
K10K4_RS04175	COG0326	Molecular chaperone. Has ATPase activity
K10K4_RS04185	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
K10K4_RS04190	COG3104	oligopeptide transport
K10K4_RS04195	COG0250	Participates in transcription elongation, termination and antitermination
K10K4_RS04200	COG0367	asparagine synthase
K10K4_RS04205	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K10K4_RS04205	COG4651	solute:proton antiporter activity
K10K4_RS04210	COG1846	Transcriptional regulator
K10K4_RS04210	COG1940	carbohydrate kinase activity
K10K4_RS04215	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K10K4_RS04225	COG2190	(PTS) system
K10K4_RS04225	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K10K4_RS04225	COG1263	PTS System
K10K4_RS04230	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K10K4_RS04235	COG0735	belongs to the Fur family
K10K4_RS04245	COG0716	FMN binding
K10K4_RS04255	COG0596	Alpha beta hydrolase
K10K4_RS04260	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
K10K4_RS04265	COG0033	Phosphoglucomutase
K10K4_RS04275	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
K10K4_RS04290	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
K10K4_RS04295	COG1053	succinate dehydrogenase
K10K4_RS04300	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K10K4_RS04305	COG0567	Dehydrogenase, E1 component
K10K4_RS04310	COG0508	dehydrogenase complex catalyzes the overall conversion of
K10K4_RS04315	COG0045	succinate-CoA ligase (ADP-forming) activity
K10K4_RS04325	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K10K4_RS04330	COG1121	(ABC) transporter
K10K4_RS04335	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
K10K4_RS04340	COG4977	sequence-specific DNA binding
K10K4_RS04345	COG1918	ferrous iron import across plasma membrane
K10K4_RS04370	COG0018	arginyl-trna synthetase
K10K4_RS04375	COG3102	Protein conserved in bacteria
K10K4_RS04390	COG0788	formyltetrahydrofolate deformylase activity
K10K4_RS04395	COG1199	ATP-dependent helicase activity
K10K4_RS04400	COG1214	PFAM Peptidase M22, glycoprotease
K10K4_RS04410	COG3065	identical protein binding
K10K4_RS04415	COG2267	carboxylic ester hydrolase activity
K10K4_RS04420	COG0318	PFAM AMP-dependent synthetase and ligase
K10K4_RS04425	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
K10K4_RS04430	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
K10K4_RS04435	COG2894	cell division
K10K4_RS04440	COG0850	regulation of cytokinetic process
K10K4_RS04445	COG3100	YcgL domain-containing protein
K10K4_RS04450	COG2951	lytic endotransglycosylase activity
K10K4_RS04460	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K10K4_RS04465	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K10K4_RS04475	COG2226	methyltransferase
K10K4_RS04485	COG1028	Short-chain dehydrogenase reductase Sdr
K10K4_RS04495	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K10K4_RS04520	COG2986	histidine ammonia-lyase
K10K4_RS04525	COG1216	Glycosyl transferase, family 2
K10K4_RS04530	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K10K4_RS04545	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K10K4_RS04550	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K10K4_RS04585	COG0513	Belongs to the DEAD box helicase family
K10K4_RS04590	COG0569	domain protein
K10K4_RS04595	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K10K4_RS04610	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
K10K4_RS04615	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K10K4_RS04620	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K10K4_RS04625	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K10K4_RS04650	COG0544	peptidyl-prolyl cis-trans isomerase activity
K10K4_RS04660	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K10K4_RS04665	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K10K4_RS04670	COG0776	regulation of translation
K10K4_RS04675	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K10K4_RS04680	COG1555	photosystem II stabilization
K10K4_RS04695	COG0232	Belongs to the dGTPase family. Type 2 subfamily
K10K4_RS04700	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
K10K4_RS04705	COG0436	Aminotransferase
K10K4_RS04710	COG1169	isochorismate synthase
K10K4_RS04715	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
K10K4_RS04725	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
K10K4_RS04745	COG2855	membrane
K10K4_RS04750	COG0477	Major facilitator Superfamily
K10K4_RS04795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K10K4_RS04800	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K10K4_RS04815	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K10K4_RS04820	COG1522	sequence-specific DNA binding
K10K4_RS04830	COG1946	Acyl-CoA thioesterase
K10K4_RS04835	COG3126	Type III secretion system lipoprotein chaperone (YscW)
K10K4_RS04860	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K10K4_RS04865	COG0516	GMP reductase activity
K10K4_RS04865	COG0517	IMP dehydrogenase activity
K10K4_RS04890	COG0537	adenosine 5'-monophosphoramidase activity
K10K4_RS04915	COG3150	esterase
K10K4_RS04920	COG1252	NADH dehydrogenase
K10K4_RS04935	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K10K4_RS04945	COG4591	ABC-type transport system involved in lipoprotein release permease component
K10K4_RS04950	COG1136	(ABC) transporter
K10K4_RS04955	COG4591	ABC-type transport system involved in lipoprotein release permease component
K10K4_RS04965	COG2333	competence protein COMEC
K10K4_RS04965	COG0658	competence protein
K10K4_RS04970	COG1132	(ABC) transporter
K10K4_RS04990	COG2719	SpoVR family
K10K4_RS04995	COG2718	Belongs to the UPF0229 family
K10K4_RS05000	COG2766	serine protein kinase
K10K4_RS05010	COG3013	Belongs to the UPF0304 family
K10K4_RS05020	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K10K4_RS05030	COG1882	Formate acetyltransferase
K10K4_RS05070	COG0708	Exodeoxyribonuclease III
K10K4_RS05080	COG3923	Primosomal replication protein n
K10K4_RS05085	COG0730	response to heat
K10K4_RS05090	COG1199	ATP-dependent helicase activity
K10K4_RS05100	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K10K4_RS05105	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
K10K4_RS05110	COG1187	pseudouridine synthase activity
K10K4_RS05120	COG1278	Cold shock
K10K4_RS05125	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
K10K4_RS05130	COG0542	response to heat
K10K4_RS05135	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K10K4_RS05140	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
K10K4_RS05145	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
K10K4_RS05165	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K10K4_RS05170	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K10K4_RS05175	COG0297	glycogen (starch) synthase activity
K10K4_RS05195	COG3070	regulator of competence-specific genes
K10K4_RS05200	COG1609	Transcriptional regulator
K10K4_RS05205	COG3381	protein complex oligomerization
K10K4_RS05210	COG0745	RESPONSE REGULATOR receiver
K10K4_RS05215	COG1434	Gram-negative-bacterium-type cell wall biogenesis
K10K4_RS05220	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K10K4_RS05225	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
K10K4_RS05230	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
K10K4_RS05235	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K10K4_RS05255	COG0189	ligase activity
K10K4_RS05255	COG4067	protein conserved in archaea
K10K4_RS05265	COG0500	methyltransferase
K10K4_RS05275	COG1801	Protein of unknown function DUF72
K10K4_RS05285	COG0217	transcriptional regulatory protein
K10K4_RS05290	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
K10K4_RS05295	COG0632	four-way junction helicase activity
K10K4_RS05300	COG2255	four-way junction helicase activity
K10K4_RS05305	COG1271	oxidase subunit
K10K4_RS05310	COG1294	oxidase, subunit
K10K4_RS05315	COG4890	Cyd operon protein YbgT
K10K4_RS05325	COG0824	Thioesterase
K10K4_RS05330	COG0811	peptide transport
K10K4_RS05345	COG0823	Involved in the tonB-independent uptake of proteins
K10K4_RS05350	COG2885	chlorophyll binding
K10K4_RS05355	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
K10K4_RS05360	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
K10K4_RS05370	COG3766	membrane
K10K4_RS05380	COG0754	glutathionylspermidine amidase activity
K10K4_RS05390	COG5002	protein histidine kinase activity
K10K4_RS05390	COG0784	Response regulator, receiver
K10K4_RS05405	COG1294	oxidase, subunit
K10K4_RS05410	COG1271	oxidase subunit
K10K4_RS05435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K10K4_RS05440	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K10K4_RS05465	COG3568	Endonuclease Exonuclease Phosphatase
K10K4_RS05490	COG0583	DNA-binding transcription factor activity
K10K4_RS05500	COG0686	Belongs to the AlaDH PNT family
K10K4_RS05510	COG1674	ftsk spoiiie
K10K4_RS05520	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K10K4_RS05540	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K10K4_RS05545	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K10K4_RS05565	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
K10K4_RS05585	COG0300	oxidoreductase activity
K10K4_RS05600	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K10K4_RS05610	COG2268	Band 7 protein
K10K4_RS05620	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K10K4_RS05625	COG2915	High frequency lysogenization protein hflD homolog
K10K4_RS05640	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K10K4_RS05650	COG1757	Na H antiporter
K10K4_RS05660	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K10K4_RS05670	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
K10K4_RS05670	COG0131	Imidazoleglycerol-phosphate dehydratase
K10K4_RS05675	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
K10K4_RS05680	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K10K4_RS05690	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K10K4_RS05690	COG0140	phosphoribosyl-ATP diphosphatase activity
K10K4_RS05695	COG3012	SEC-C Motif Domain Protein
K10K4_RS05700	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
K10K4_RS05705	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K10K4_RS05710	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K10K4_RS05715	COG0215	cysteine-tRNA ligase activity
K10K4_RS05720	COG1435	thymidine kinase activity
K10K4_RS05750	COG2116	formate transmembrane transporter activity
K10K4_RS05760	COG0390	transport system, permease component
K10K4_RS05765	COG4459	periplasmic nitrate reductase
K10K4_RS05770	COG3005	denitrification pathway
K10K4_RS05775	COG0243	molybdopterin cofactor binding
K10K4_RS05790	COG1227	inorganic diphosphatase activity
K10K4_RS05800	COG4172	Belongs to the ABC transporter superfamily
K10K4_RS05810	COG4171	peptide transport system, permease
K10K4_RS05825	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
K10K4_RS05830	COG1842	Phage shock protein A
K10K4_RS05840	COG1983	PspC domain protein
K10K4_RS05860	COG2818	Glycosylase
K10K4_RS05865	COG5380	lipid catabolic process
K10K4_RS05870	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
K10K4_RS05875	COG0626	cystathionine gamma-synthase activity
K10K4_RS05885	COG0733	neurotransmitter:sodium symporter activity
K10K4_RS05890	COG0564	pseudouridine synthase activity
K10K4_RS05900	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K10K4_RS05905	COG1151	hydroxylamine reductase activity
K10K4_RS05910	COG3604	Transcriptional regulator
K10K4_RS05920	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K10K4_RS05925	COG4136	ATPase activity
K10K4_RS05930	COG4135	transport system, permease component
K10K4_RS05935	COG4134	Bacterial extracellular solute-binding protein
K10K4_RS05945	COG3313	Fe-S protein
K10K4_RS05965	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
K10K4_RS05985	COG1061	Type III restriction enzyme res subunit
K10K4_RS05990	COG1187	pseudouridine synthase activity
K10K4_RS06000	COG2814	Major facilitator Superfamily
K10K4_RS06010	COG0702	epimerase
K10K4_RS06015	COG0534	Mate efflux family protein
K10K4_RS06035	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K10K4_RS06050	COG1960	acyl-CoA dehydrogenase activity
K10K4_RS06055	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K10K4_RS06060	COG3273	potassium ion transport
K10K4_RS06060	COG2985	domain, Protein
K10K4_RS06065	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K10K4_RS06075	COG1737	Transcriptional regulator
K10K4_RS06080	COG0076	glutamate decarboxylase activity
K10K4_RS06090	COG2431	L-lysine efflux transmembrane transporter activity
K10K4_RS06110	COG3070	regulator of competence-specific genes
K10K4_RS06125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K10K4_RS06125	COG4191	Histidine kinase
K10K4_RS06135	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
K10K4_RS06145	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
K10K4_RS06150	COG4988	ABC transporter
K10K4_RS06155	COG0492	ferredoxin-NADP+ reductase activity
K10K4_RS06180	COG0471	metal ion transport
K10K4_RS06185	COG2949	membrane
K10K4_RS06190	COG0281	malic enzyme
K10K4_RS06195	COG1643	Atp-dependent helicase
K10K4_RS06210	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K10K4_RS06245	COG0277	FAD linked oxidase domain protein
K10K4_RS06245	COG0247	lactate metabolic process
K10K4_RS06260	COG2986	histidine ammonia-lyase
K10K4_RS06265	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
K10K4_RS06270	COG0010	Belongs to the arginase family
K10K4_RS06275	COG1228	amidohydrolase
K10K4_RS06280	COG2188	Transcriptional regulator
K10K4_RS06295	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K10K4_RS06305	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K10K4_RS06315	COG0393	Putative heavy-metal-binding
K10K4_RS06350	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K10K4_RS06355	COG0072	phenylalanine-tRNA ligase activity
K10K4_RS06355	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K10K4_RS06365	COG0776	regulation of translation
K10K4_RS06375	COG0500	methyltransferase
K10K4_RS06380	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
K10K4_RS06385	COG0295	cytidine deaminase activity
K10K4_RS06390	COG1346	cytolysis
K10K4_RS06395	COG1380	Effector of murein hydrolase LrgA
K10K4_RS06400	COG2925	Exonuclease
K10K4_RS06455	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K10K4_RS06480	COG1484	DNA-dependent DNA replication
K10K4_RS06625	COG1823	symporter activity
K10K4_RS06630	COG0702	epimerase
K10K4_RS06635	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
K10K4_RS06640	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
K10K4_RS06660	COG2988	succinylglutamate desuccinylase activity
K10K4_RS06665	COG4139	cobalamin transport
K10K4_RS06670	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
K10K4_RS06690	COG0583	DNA-binding transcription factor activity
K10K4_RS06700	COG1451	nucleotide metabolic process
K10K4_RS06705	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
K10K4_RS06735	COG3938	Belongs to the proline racemase family
K10K4_RS06750	COG2423	ornithine cyclodeaminase activity
K10K4_RS06755	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K10K4_RS06760	COG3842	ATPase activity
K10K4_RS06765	COG1176	ABC-type spermidine putrescine transport system, permease component I
K10K4_RS06770	COG1177	transmembrane transport
K10K4_RS06780	COG3291	Pkd domain containing protein
K10K4_RS06800	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K10K4_RS06805	COG0601	transmembrane transport
K10K4_RS06815	COG2195	Cleaves the N-terminal amino acid of tripeptides
K10K4_RS06825	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
K10K4_RS06835	COG0625	glutathione transferase activity
K10K4_RS06885	COG3755	Protein conserved in bacteria
K10K4_RS06910	COG1742	UPF0060 membrane protein
K10K4_RS06925	COG1757	Na H antiporter
K10K4_RS06930	COG0174	glutamine synthetase
K10K4_RS06940	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
K10K4_RS06945	COG1396	sequence-specific DNA binding
K10K4_RS06945	COG1917	Cupin 2, conserved barrel domain protein
K10K4_RS06950	COG1012	belongs to the aldehyde dehydrogenase family
K10K4_RS06955	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K10K4_RS06965	COG2957	Belongs to the agmatine deiminase family
K10K4_RS06970	COG1012	belongs to the aldehyde dehydrogenase family
K10K4_RS06975	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K10K4_RS06980	COG2200	EAL domain
K10K4_RS06990	COG1846	Transcriptional regulator
K10K4_RS06995	COG2315	Protein conserved in bacteria
K10K4_RS07035	COG3063	Type IV pilus biogenesis stability protein PilW
K10K4_RS07040	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
K10K4_RS07055	COG1560	Kdo2-lipid A biosynthetic process
K10K4_RS07060	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
K10K4_RS07065	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K10K4_RS07190	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
K10K4_RS07195	COG1280	lysine exporter protein (LysE YggA)
K10K4_RS07205	COG1115	amino acid carrier protein
K10K4_RS07230	COG1368	sulfuric ester hydrolase activity
K10K4_RS07235	COG2113	Glycine betaine
K10K4_RS07240	COG4176	ABC-type proline glycine betaine transport system permease component
K10K4_RS07245	COG4175	Glycine betaine
K10K4_RS07260	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K10K4_RS07265	COG0456	acetyltransferase
K10K4_RS07270	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K10K4_RS07275	COG0662	Cupin 2, conserved barrel domain protein
K10K4_RS07280	COG0527	aspartate kinase activity
K10K4_RS07285	COG3119	arylsulfatase activity
K10K4_RS07300	COG0641	radical SAM
K10K4_RS07315	COG3119	arylsulfatase activity
K10K4_RS07340	COG1538	Outer membrane efflux protein
K10K4_RS07355	COG1349	DNA-binding transcription factor activity
K10K4_RS07360	COG0673	inositol 2-dehydrogenase activity
K10K4_RS07365	COG4702	Belongs to the UPF0303 family
K10K4_RS07390	COG0471	metal ion transport
K10K4_RS07405	COG5001	Diguanylate cyclase
K10K4_RS07405	COG3300	MHYT domain
K10K4_RS07420	COG1328	CTP reductase activity
K10K4_RS07425	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K10K4_RS07435	COG0861	Integral membrane protein TerC family
K10K4_RS07445	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
K10K4_RS07455	COG0814	amino acid
K10K4_RS07470	COG1120	ATPase activity
K10K4_RS07475	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K10K4_RS07485	COG4774	siderophore transport
K10K4_RS07495	COG1132	(ABC) transporter
K10K4_RS07500	COG1132	(ABC) transporter
K10K4_RS07515	COG0583	DNA-binding transcription factor activity
K10K4_RS07540	COG0443	Heat shock 70 kDa protein
K10K4_RS07545	COG0443	Heat shock 70 kDa protein
K10K4_RS07590	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
K10K4_RS07595	COG1643	Atp-dependent helicase
K10K4_RS07610	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K10K4_RS07620	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K10K4_RS07625	COG1215	transferase activity, transferring glycosyl groups
K10K4_RS07630	COG0438	transferase activity, transferring glycosyl groups
K10K4_RS07660	COG0438	transferase activity, transferring glycosyl groups
K10K4_RS07665	COG0438	transferase activity, transferring glycosyl groups
K10K4_RS07670	COG2204	response regulator
K10K4_RS07705	COG1793	dna ligase
K10K4_RS07715	COG0534	Mate efflux family protein
K10K4_RS07720	COG0307	riboflavin synthase, alpha
K10K4_RS07730	COG3001	Fructosamine kinase
K10K4_RS07740	COG3706	GGDEF domain
K10K4_RS07750	COG0791	NLP P60 protein
K10K4_RS07785	COG3148	PFAM DTW domain containing protein
K10K4_RS07790	COG1940	carbohydrate kinase activity
K10K4_RS07805	COG0746	molybdenum cofactor guanylyltransferase activity
K10K4_RS07810	COG3842	ATPase activity
K10K4_RS07825	COG2204	response regulator
K10K4_RS07830	COG4191	Histidine kinase
K10K4_RS07835	COG0488	(ABC) transporter
K10K4_RS07840	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K10K4_RS07860	COG3381	protein complex oligomerization
K10K4_RS07870	COG0243	molybdopterin cofactor binding
K10K4_RS07870	COG3383	formate dehydrogenase (NAD+) activity
K10K4_RS07875	COG0437	4 iron, 4 sulfur cluster binding
K10K4_RS07900	COG0004	ammonium transporteR
K10K4_RS07905	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K10K4_RS07910	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K10K4_RS07920	COG1177	transmembrane transport
K10K4_RS07930	COG3842	ATPase activity
K10K4_RS07955	COG0589	response to stress
K10K4_RS07960	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K10K4_RS07975	COG2217	Heavy metal translocating P-type atpase
K10K4_RS07985	COG2010	Cytochrome c
K10K4_RS08000	COG3278	Belongs to the heme-copper respiratory oxidase family
K10K4_RS08015	COG0784	Response regulator, receiver
K10K4_RS08015	COG2205	protein histidine kinase activity
K10K4_RS08065	COG4128	Pfam Zonular occludens toxin
K10K4_RS08095	COG3120	sequence-specific DNA binding
K10K4_RS08100	COG1067	ATP-dependent peptidase activity
K10K4_RS08105	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K10K4_RS08120	COG0488	(ABC) transporter
K10K4_RS08130	COG0116	Belongs to the methyltransferase superfamily
K10K4_RS08130	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K10K4_RS08140	COG0167	dihydroorotate dehydrogenase activity
K10K4_RS08145	COG2902	Dehydrogenase
K10K4_RS08155	COG0308	aminopeptidase N
K10K4_RS08170	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
K10K4_RS08175	COG1956	GAF domain-containing protein
K10K4_RS08180	COG1132	(ABC) transporter
K10K4_RS08185	COG2995	paraquat-inducible protein a
K10K4_RS08190	COG3008	intermembrane lipid transfer
K10K4_RS08215	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K10K4_RS08220	COG1666	GTP binding
K10K4_RS08235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K10K4_RS08240	COG4597	amino acid ABC transporter
K10K4_RS08245	COG0765	amino acid transport
K10K4_RS08250	COG1126	abc transporter atp-binding protein
K10K4_RS08255	COG0670	Belongs to the BI1 family
K10K4_RS08270	COG2920	part of a sulfur-relay system
K10K4_RS08275	COG1254	Belongs to the acylphosphatase family
K10K4_RS08280	COG0840	transmembrane signaling receptor activity
K10K4_RS08300	COG2885	chlorophyll binding
K10K4_RS08325	COG2203	Gaf domain
K10K4_RS08325	COG2199	diguanylate cyclase activity
K10K4_RS08330	COG1414	Transcriptional regulator
K10K4_RS08340	COG0656	L-ascorbic acid biosynthetic process
K10K4_RS08345	COG0583	DNA-binding transcription factor activity
K10K4_RS08355	COG0583	DNA-binding transcription factor activity
K10K4_RS08360	COG2814	Major facilitator Superfamily
K10K4_RS08380	COG1335	isochorismatase
K10K4_RS08385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K10K4_RS08400	COG0646	methionine synthase
K10K4_RS08400	COG1410	methionine synthase
K10K4_RS08405	COG1126	abc transporter atp-binding protein
K10K4_RS08410	COG0765	amino acid transport
K10K4_RS08415	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K10K4_RS08430	COG0583	DNA-binding transcription factor activity
K10K4_RS08445	COG0583	DNA-binding transcription factor activity
K10K4_RS08455	COG0583	DNA-binding transcription factor activity
K10K4_RS08470	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
K10K4_RS08475	COG0602	queuosine metabolic process
K10K4_RS08480	COG0561	phosphatase activity
K10K4_RS08505	COG2828	Protein conserved in bacteria
K10K4_RS08515	COG0372	Belongs to the citrate synthase family
K10K4_RS08520	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
K10K4_RS08555	COG0730	response to heat
K10K4_RS08560	COG2358	TRAP transporter, solute receptor (TAXI family
K10K4_RS08575	COG0457	Tetratricopeptide repeat
K10K4_RS08645	COG4790	Type iii secretion
K10K4_RS08650	COG4794	Type iii secretion
K10K4_RS08655	COG4791	protein targeting
K10K4_RS08660	COG4792	protein secretion
K10K4_RS08665	COG2207	Transcriptional regulator
K10K4_RS08695	COG3177	Filamentation induced by cAMP protein fic
K10K4_RS08715	COG4669	(LipO)protein
K10K4_RS08785	COG1012	belongs to the aldehyde dehydrogenase family
K10K4_RS08790	COG3284	Transcriptional regulator
K10K4_RS08805	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
K10K4_RS08810	COG0363	glucosamine-6-phosphate deaminase activity
K10K4_RS08815	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K10K4_RS08820	COG2207	Transcriptional regulator
K10K4_RS08830	COG4565	transcriptional regulatory protein
K10K4_RS08835	COG3290	protein histidine kinase activity
K10K4_RS08850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K10K4_RS08865	COG0583	DNA-binding transcription factor activity
K10K4_RS08880	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
K10K4_RS08890	COG2985	domain, Protein
K10K4_RS08915	COG2272	Belongs to the type-B carboxylesterase lipase family
K10K4_RS08925	COG0729	surface antigen
K10K4_RS08935	COG1280	lysine exporter protein (LysE YggA)
K10K4_RS08940	COG1280	lysine exporter protein (LysE YggA)
K10K4_RS08945	COG5507	3-demethylubiquinone-9 3-methyltransferase
K10K4_RS08965	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K10K4_RS08975	COG0110	maltose O-acetyltransferase activity
K10K4_RS09025	COG2801	Transposase and inactivated derivatives
K10K4_RS09055	COG1683	Conserved Protein
K10K4_RS09140	COG2801	Transposase and inactivated derivatives
K10K4_RS09175	COG1403	HNH endonuclease
K10K4_RS09265	COG4974	Belongs to the 'phage' integrase family
K10K4_RS09275	COG3706	GGDEF domain
K10K4_RS09290	COG2985	domain, Protein
K10K4_RS09295	COG0076	glutamate decarboxylase activity
K10K4_RS09300	COG2963	transposase activity
K10K4_RS09305	COG0598	Magnesium transport protein CorA
K10K4_RS09315	COG0387	Pfam Sodium calcium exchanger
K10K4_RS09320	COG0387	Pfam Sodium calcium exchanger
K10K4_RS09335	COG1289	transmembrane transporter activity
K10K4_RS09350	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
K10K4_RS09360	COG2985	domain, Protein
K10K4_RS09365	COG0025	NhaP-type Na H and K H
K10K4_RS09390	COG3302	dmso reductase anchor subunit
K10K4_RS09395	COG0437	4 iron, 4 sulfur cluster binding
K10K4_RS09400	COG0243	molybdopterin cofactor binding
K10K4_RS09410	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K10K4_RS09410	COG2221	Nitrite and sulphite reductase 4Fe-4S
K10K4_RS09415	COG2205	protein histidine kinase activity
K10K4_RS09415	COG0784	Response regulator, receiver
K10K4_RS09490	COG3477	response to acidic pH
K10K4_RS09495	COG2199	diguanylate cyclase activity
K10K4_RS09495	COG3287	FIST C domain
K10K4_RS09495	COG2200	EAL domain
K10K4_RS09500	COG2197	response regulator
K10K4_RS09570	COG1472	Belongs to the glycosyl hydrolase 3 family
K10K4_RS09580	COG2205	protein histidine kinase activity
K10K4_RS09580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K10K4_RS09585	COG2197	response regulator
K10K4_RS09660	COG1335	isochorismatase
K10K4_RS09770	COG4628	conserved protein (DUF2132)
K10K4_RS09820	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K10K4_RS09830	COG3768	UPF0283 membrane protein
K10K4_RS09835	COG3106	COG3106 Predicted ATPase
K10K4_RS09850	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K10K4_RS09855	COG0784	Response regulator, receiver
K10K4_RS09855	COG2205	protein histidine kinase activity
K10K4_RS09865	COG0494	nUDIX hydrolase
K10K4_RS09870	COG0814	amino acid
K10K4_RS09875	COG1760	l-serine dehydratase
K10K4_RS09880	COG2200	EAL domain
K10K4_RS09890	COG0720	synthase
K10K4_RS09895	COG0840	transmembrane signaling receptor activity
K10K4_RS09900	COG0017	Asparaginyl-tRNA synthetase
K10K4_RS09910	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K10K4_RS09925	COG1448	Aminotransferase
K10K4_RS09945	COG0840	transmembrane signaling receptor activity
K10K4_RS09950	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K10K4_RS09980	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
K10K4_RS09995	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K10K4_RS10000	COG3108	Peptidase M15
K10K4_RS10005	COG2989	Protein conserved in bacteria
K10K4_RS10030	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K10K4_RS10040	COG3088	subunit of a heme lyase
K10K4_RS10040	COG4235	cytochrome complex assembly
K10K4_RS10050	COG1138	Cytochrome C-type biogenesis protein
K10K4_RS10055	COG3301	Polysulphide reductase, NrfD
K10K4_RS10060	COG0437	4 iron, 4 sulfur cluster binding
K10K4_RS10070	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
K10K4_RS10090	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K10K4_RS10095	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K10K4_RS10125	COG0019	diaminopimelate decarboxylase activity
K10K4_RS10170	COG0322	excinuclease ABC activity
K10K4_RS10175	COG2197	response regulator
K10K4_RS10180	COG0417	DNA replication proofreading
K10K4_RS10200	COG1187	pseudouridine synthase activity
K10K4_RS10210	COG0009	L-threonylcarbamoyladenylate synthase
K10K4_RS10215	COG0613	PHP domain protein
K10K4_RS10225	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K10K4_RS10230	COG0512	Glutamine amidotransferase of anthranilate synthase
K10K4_RS10240	COG0135	phosphoribosylanthranilate isomerase activity
K10K4_RS10240	COG0134	indole-3-glycerol-phosphate synthase activity
K10K4_RS10250	COG0159	tryptophan synthase activity
K10K4_RS10255	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K10K4_RS10260	COG0318	PFAM AMP-dependent synthetase and ligase
K10K4_RS10270	COG1301	dicarboxylic acid transport
K10K4_RS10290	COG2917	probably involved in intracellular septation
K10K4_RS10300	COG2350	Protein conserved in bacteria
K10K4_RS10310	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
K10K4_RS10315	COG0583	DNA-binding transcription factor activity
K10K4_RS10330	COG5001	Diguanylate cyclase
K10K4_RS10335	COG1032	radical SAM domain protein
K10K4_RS10355	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
K10K4_RS10360	COG0463	Glycosyl transferase, family 2
K10K4_RS10365	COG0745	RESPONSE REGULATOR receiver
K10K4_RS10370	COG5002	protein histidine kinase activity
K10K4_RS10370	COG3850	Histidine kinase
K10K4_RS10420	COG0577	efflux transmembrane transporter activity
K10K4_RS10420	COG1136	(ABC) transporter
K10K4_RS10425	COG0577	efflux transmembrane transporter activity
K10K4_RS10425	COG1136	(ABC) transporter
K10K4_RS10430	COG0577	efflux transmembrane transporter activity
K10K4_RS10430	COG1136	(ABC) transporter
K10K4_RS10440	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K10K4_RS10465	COG3118	belongs to the thioredoxin family
K10K4_RS10470	COG4232	protein-disulfide reductase activity
K10K4_RS10505	COG2863	cytochrome
K10K4_RS10510	COG3258	Cytochrome c
K10K4_RS10515	COG2995	paraquat-inducible protein a
K10K4_RS10520	COG3008	intermembrane lipid transfer
K10K4_RS10520	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K10K4_RS10540	COG4166	transmembrane transport
K10K4_RS10550	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
K10K4_RS10555	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
K10K4_RS10565	COG0539	negative regulation of cytoplasmic translation
K10K4_RS10570	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K10K4_RS10575	COG0616	signal peptide processing
K10K4_RS10580	COG1028	Short-chain dehydrogenase reductase Sdr
K10K4_RS10595	COG0587	DNA-directed DNA polymerase activity
K10K4_RS10600	COG0835	chemotaxis
K10K4_RS10600	COG0784	Response regulator, receiver
K10K4_RS10605	COG1940	carbohydrate kinase activity
K10K4_RS10610	COG0469	pyruvate kinase activity
K10K4_RS10615	COG4667	esterase of the alpha-beta hydrolase superfamily
K10K4_RS10630	COG0733	neurotransmitter:sodium symporter activity
K10K4_RS10645	COG1263	PTS System
K10K4_RS10645	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K10K4_RS10650	COG0084	hydrolase, TatD family'
K10K4_RS10655	COG0470	DNA polymerase III
K10K4_RS10660	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K10K4_RS10665	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K10K4_RS10695	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K10K4_RS10700	COG0416	fatty acid biosynthetic process
K10K4_RS10710	COG1399	metal-binding, possibly nucleic acid-binding protein
K10K4_RS10715	COG0424	maF-like protein
K10K4_RS10720	COG0564	pseudouridine synthase activity
K10K4_RS10730	COG1530	ribonuclease E activity
K10K4_RS10740	COG0659	secondary active sulfate transmembrane transporter activity
K10K4_RS10745	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K10K4_RS10750	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
K10K4_RS10760	COG0572	uridine kinase
K10K4_RS10770	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K10K4_RS10770	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K10K4_RS10790	COG2186	Transcriptional regulator
K10K4_RS10795	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K10K4_RS10800	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
K10K4_RS10805	COG3012	SEC-C Motif Domain Protein
K10K4_RS10805	COG3318	Belongs to the UPF0149 family
K10K4_RS10810	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K10K4_RS10815	COG3706	GGDEF domain
K10K4_RS10820	COG0366	Alpha amylase catalytic
K10K4_RS10825	COG1122	ATPase activity
K10K4_RS10830	COG4120	Belongs to the binding-protein-dependent transport system permease family
K10K4_RS10840	COG3092	negative regulation of chromosome organization
K10K4_RS10845	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K10K4_RS10850	COG0280	phosphate acetyltransferase
K10K4_RS10850	COG0857	belongs to the CobB CobQ family
K10K4_RS10860	COG0435	Glutathione S-transferase
K10K4_RS10870	COG0444	Belongs to the ABC transporter superfamily
K10K4_RS10875	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K10K4_RS10880	COG0601	transmembrane transport
K10K4_RS10890	COG0314	molybdopterin synthase activity
K10K4_RS10895	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
K10K4_RS10900	COG0315	cyclic pyranopterin monophosphate synthase activity
K10K4_RS10905	COG0521	Mo-molybdopterin cofactor biosynthetic process
K10K4_RS10910	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K10K4_RS10915	COG0391	Required for morphogenesis under gluconeogenic growth conditions
K10K4_RS10920	COG2198	Histidine kinase
K10K4_RS10925	COG2204	response regulator
K10K4_RS10930	COG0556	nucleotide-excision repair
K10K4_RS10940	COG1882	Formate acetyltransferase
K10K4_RS10945	COG4657	Part of a membrane complex involved in electron transport
K10K4_RS10950	COG2878	Part of a membrane complex involved in electron transport
K10K4_RS10955	COG4656	Part of a membrane complex involved in electron transport
K10K4_RS10960	COG4658	electron transport chain
K10K4_RS10965	COG4659	FMN binding
K10K4_RS10970	COG4660	Part of a membrane complex involved in electron transport
K10K4_RS10975	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K10K4_RS10980	COG0346	lactoylglutathione lyase activity
K10K4_RS10990	COG2885	chlorophyll binding
K10K4_RS10995	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K10K4_RS11000	COG2056	Na+-H+ antiporter family
K10K4_RS11020	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
K10K4_RS11045	COG1454	alcohol dehydrogenase
K10K4_RS11045	COG1012	belongs to the aldehyde dehydrogenase family
K10K4_RS11050	COG2095	MarC family integral membrane protein
K10K4_RS11055	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K10K4_RS11060	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K10K4_RS11065	COG1757	Na H antiporter
K10K4_RS11080	COG3081	Nucleoid-associated protein
K10K4_RS11085	COG3082	Protein of unknown function (DUF1414)
K10K4_RS11100	COG0123	including yeast histone deacetylase and acetoin utilization protein
K10K4_RS11115	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K10K4_RS11120	COG0778	Nitroreductase
K10K4_RS11130	COG1902	pentaerythritol trinitrate reductase activity
K10K4_RS11130	COG0446	pyridine nucleotide-disulphide oxidoreductase
K10K4_RS11135	COG0616	signal peptide processing
K10K4_RS11140	COG0252	asparaginase activity
K10K4_RS11145	COG3139	Protein of unknown function (DUF1315)
K10K4_RS11155	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K10K4_RS11160	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K10K4_RS11175	COG2226	methyltransferase
K10K4_RS11190	COG1785	Belongs to the alkaline phosphatase family
K10K4_RS11200	COG0346	lactoylglutathione lyase activity
K10K4_RS11205	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
K10K4_RS11210	COG0668	transmembrane transport
K10K4_RS11215	COG2983	Belongs to the UPF0260 family
K10K4_RS11220	COG2261	transglycosylase associated protein
K10K4_RS11230	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K10K4_RS11235	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K10K4_RS11250	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K10K4_RS11255	COG2832	Protein of unknown function (DUF454)
K10K4_RS11265	COG0745	RESPONSE REGULATOR receiver
K10K4_RS11270	COG0583	DNA-binding transcription factor activity
K10K4_RS11275	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
K10K4_RS11280	COG1286	toxin biosynthetic process
K10K4_RS11285	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
K10K4_RS11290	COG0285	dihydrofolate synthase activity
K10K4_RS11295	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K10K4_RS11305	COG0101	tRNA pseudouridine synthase activity
K10K4_RS11315	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K10K4_RS11320	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K10K4_RS11330	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K10K4_RS11335	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K10K4_RS11335	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
K10K4_RS11340	COG0431	NADPH-dependent FMN reductase
K10K4_RS11355	COG3101	peptidyl-lysine hydroxylation
K10K4_RS11365	COG2860	membrane
K10K4_RS11370	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K10K4_RS11375	COG2890	protein-(glutamine-N5) methyltransferase activity
K10K4_RS11380	COG2840	Smr protein MutS2
K10K4_RS11385	COG2062	phosphohistidine phosphatase, SixA
K10K4_RS11400	COG1250	3-hydroxyacyl-CoA dehydrogenase
K10K4_RS11400	COG1024	Enoyl-CoA hydratase
K10K4_RS11405	COG0183	Belongs to the thiolase family
K10K4_RS11430	COG2067	long-chain fatty acid transport protein
K10K4_RS11440	COG3088	subunit of a heme lyase
K10K4_RS11440	COG4235	cytochrome complex assembly
K10K4_RS11450	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K10K4_RS11455	COG1138	Cytochrome C-type biogenesis protein
K10K4_RS11460	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
K10K4_RS11465	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K10K4_RS11470	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K10K4_RS11475	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K10K4_RS11480	COG4133	protoheme IX ABC transporter activity
K10K4_RS11490	COG0835	chemotaxis
K10K4_RS11500	COG1192	Involved in chromosome partitioning
K10K4_RS11505	COG2201	protein-glutamate methylesterase activity
K10K4_RS11510	COG0643	Histidine kinase
K10K4_RS11510	COG2198	Histidine kinase
K10K4_RS11510	COG0784	Response regulator, receiver
K10K4_RS11515	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
K10K4_RS11550	COG1684	flagellar biosynthetic protein fliR
K10K4_RS11555	COG1987	bacterial-type flagellum assembly
K10K4_RS11610	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K10K4_RS11620	COG1677	Flagellar hook-basal body complex protein FliE
K10K4_RS11640	COG1516	flagellar protein fliS
K10K4_RS11650	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
K10K4_RS11655	COG1334	flagellar protein FlaG
K10K4_RS11660	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K10K4_RS11665	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K10K4_RS11675	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K10K4_RS11680	COG2837	iron assimilation
K10K4_RS11705	COG1393	Belongs to the ArsC family
K10K4_RS11710	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K10K4_RS11725	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
K10K4_RS11730	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K10K4_RS11740	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K10K4_RS11765	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K10K4_RS11780	COG1053	succinate dehydrogenase
K10K4_RS11845	COG0210	DNA helicase
K10K4_RS11860	COG2205	protein histidine kinase activity
K10K4_RS11860	COG0784	Response regulator, receiver
K10K4_RS11870	COG1278	Cold shock
K10K4_RS11890	COG1278	Cold shock
K10K4_RS11895	COG4974	Belongs to the 'phage' integrase family
K10K4_RS11900	COG0330	HflC and HflK could
K10K4_RS11920	COG1278	Cold shock
K10K4_RS11940	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K10K4_RS11955	COG4783	chaperone-mediated protein folding
K10K4_RS11960	COG1393	Belongs to the ArsC family
K10K4_RS11980	COG2233	PERMEase
K10K4_RS11985	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K10K4_RS11990	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K10K4_RS11995	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K10K4_RS12000	COG0121	glutamine amidotransferase
K10K4_RS12005	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
K10K4_RS12010	COG1960	acyl-CoA dehydrogenase activity
K10K4_RS12045	COG0328	RNA-DNA hybrid ribonuclease activity
K10K4_RS12050	COG2226	methyltransferase
K10K4_RS12055	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K10K4_RS12060	COG1388	LysM domain
K10K4_RS12060	COG0741	lytic transglycosylase activity
K10K4_RS12070	COG3021	interspecies interaction between organisms
K10K4_RS12075	COG0347	Belongs to the P(II) protein family
K10K4_RS12090	COG0825	malonyl-CoA metabolic process
K10K4_RS12095	COG0587	DNA-directed DNA polymerase activity
K10K4_RS12105	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K10K4_RS12110	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K10K4_RS12120	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K10K4_RS12125	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
K10K4_RS12135	COG0750	zinc metalloprotease
K10K4_RS12140	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
K10K4_RS12145	COG0575	Belongs to the CDS family
K10K4_RS12150	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K10K4_RS12155	COG0233	cytoplasmic translational termination
K10K4_RS12160	COG0528	UMP kinase activity
K10K4_RS12165	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K10K4_RS12170	COG0052	Belongs to the universal ribosomal protein uS2 family
K10K4_RS12175	COG0024	Methionine aminopeptidase
K10K4_RS12180	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
K10K4_RS12190	COG0564	pseudouridine synthase activity
K10K4_RS12195	COG3098	single-species biofilm formation
K10K4_RS12230	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K10K4_RS12235	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K10K4_RS12260	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
K10K4_RS12270	COG0254	rRNA binding
K10K4_RS12275	COG1720	tRNA m6t6A37 methyltransferase activity
K10K4_RS12280	COG0442	prolyl-tRNA aminoacylation
K10K4_RS12300	COG0733	neurotransmitter:sodium symporter activity
K10K4_RS12315	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K10K4_RS12320	COG0514	ATP-dependent DNA helicase (RecQ)
K10K4_RS12345	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K10K4_RS12400	COG3621	Patatin-like phospholipase
K10K4_RS12435	COG0659	secondary active sulfate transmembrane transporter activity
K10K4_RS12440	COG0589	response to stress
K10K4_RS12445	COG0519	Catalyzes the synthesis of GMP from XMP
K10K4_RS12505	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K10K4_RS12525	COG1477	protein flavinylation
K10K4_RS12530	COG2871	sodium ion transport
K10K4_RS12535	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K10K4_RS12540	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K10K4_RS12545	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K10K4_RS12550	COG1805	sodium ion transport
K10K4_RS12555	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K10K4_RS12560	COG0271	Belongs to the BolA IbaG family
K10K4_RS12565	COG2813	Specifically methylates the guanine in position
K10K4_RS12570	COG3056	Lipoprotein
K10K4_RS12590	COG1595	DNA-templated transcription, initiation
K10K4_RS12615	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K10K4_RS12620	COG0693	protein deglycase activity
K10K4_RS12625	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K10K4_RS12630	COG3706	GGDEF domain
K10K4_RS12635	COG2166	iron-sulfur cluster assembly
K10K4_RS12640	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
K10K4_RS12645	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
K10K4_RS12660	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K10K4_RS12660	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
K10K4_RS12670	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K10K4_RS12675	COG1074	ATP-dependent DNA helicase activity
K10K4_RS12685	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
K10K4_RS12720	COG0270	DNA (cytosine-5-)-methyltransferase activity
K10K4_RS12745	COG3141	response to X-ray
K10K4_RS12760	COG2171	N-acyltransferase activity
K10K4_RS12765	COG0584	glycerophosphoryl diester phosphodiesterase
K10K4_RS12770	COG2271	Major facilitator Superfamily
K10K4_RS12780	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K10K4_RS12785	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
K10K4_RS12790	COG1349	DNA-binding transcription factor activity
K10K4_RS12795	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
K10K4_RS12800	COG0598	Magnesium transport protein CorA
K10K4_RS12820	COG1609	Transcriptional regulator
K10K4_RS12825	COG0583	DNA-binding transcription factor activity
K10K4_RS12865	COG1022	Amp-dependent synthetase and ligase
K10K4_RS12875	COG0583	DNA-binding transcription factor activity
K10K4_RS12880	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K10K4_RS12885	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
K10K4_RS12895	COG0560	Phosphoserine phosphatase
K10K4_RS12905	COG0813	purine-nucleoside phosphorylase activity
K10K4_RS12910	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
K10K4_RS12915	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
K10K4_RS12920	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
K10K4_RS12925	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K10K4_RS12930	COG0084	hydrolase, TatD family'
K10K4_RS12960	COG3153	acetyltransferase
K10K4_RS12965	COG3154	lipid carrier protein
K10K4_RS12980	COG0826	peptidase U32
K10K4_RS12985	COG0826	peptidase U32
K10K4_RS12990	COG0534	Mate efflux family protein
K10K4_RS13005	COG1185	polyribonucleotide nucleotidyltransferase activity
K10K4_RS13010	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K10K4_RS13015	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K10K4_RS13020	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K10K4_RS13025	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K10K4_RS13030	COG0195	Participates in both transcription termination and antitermination
K10K4_RS13035	COG0779	Required for maturation of 30S ribosomal subunits
K10K4_RS13050	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K10K4_RS13060	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K10K4_RS13065	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
K10K4_RS13070	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K10K4_RS13075	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
K10K4_RS13080	COG1534	Rna-binding protein
K10K4_RS13085	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K10K4_RS13090	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K10K4_RS13095	COG2027	D-alanyl-D-alanine carboxypeptidase
K10K4_RS13105	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K10K4_RS13110	COG0739	heme binding
K10K4_RS13135	COG0628	permease
K10K4_RS13145	COG0784	Response regulator, receiver
K10K4_RS13145	COG2205	protein histidine kinase activity
K10K4_RS13150	COG0747	negative chemotaxis
K10K4_RS13160	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K10K4_RS13165	COG0444	Belongs to the ABC transporter superfamily
K10K4_RS13170	COG4608	Belongs to the ABC transporter superfamily
K10K4_RS13180	COG2971	BadF BadG BcrA BcrD
K10K4_RS13195	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K10K4_RS13200	COG3842	ATPase activity
K10K4_RS13210	COG1840	ABC-type Fe3 transport system, periplasmic component
K10K4_RS13215	COG0004	ammonium transporteR
K10K4_RS13225	COG3112	Uncharacterised protein family (UPF0231)
K10K4_RS13230	COG1049	propionate catabolic process, 2-methylcitrate cycle
K10K4_RS13235	COG1752	Esterase of the alpha-beta hydrolase superfamily
K10K4_RS13240	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K10K4_RS13245	COG1643	Atp-dependent helicase
K10K4_RS13250	COG1489	DNA binding
K10K4_RS13260	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K10K4_RS13270	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K10K4_RS13275	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
K10K4_RS13280	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
K10K4_RS13285	COG1560	Kdo2-lipid A biosynthetic process
K10K4_RS13295	COG0842	Transport permease protein
K10K4_RS13300	COG1131	(ABC) transporter
K10K4_RS13305	COG0659	secondary active sulfate transmembrane transporter activity
K10K4_RS13310	COG0288	reversible hydration of carbon dioxide
K10K4_RS13325	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K10K4_RS13330	COG0508	dehydrogenase complex catalyzes the overall conversion of
K10K4_RS13335	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
K10K4_RS13340	COG2186	Transcriptional regulator
K10K4_RS13350	COG0157	Belongs to the NadC ModD family
K10K4_RS13355	COG4969	Belongs to the N-Me-Phe pilin family
K10K4_RS13360	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K10K4_RS13365	COG1459	type II secretion system
K10K4_RS13375	COG0237	dephospho-CoA kinase activity
K10K4_RS13380	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
K10K4_RS13385	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
K10K4_RS13400	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K10K4_RS13405	COG0228	four-way junction DNA binding
K10K4_RS13410	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K10K4_RS13415	COG4137	Cytochrome C assembly protein
K10K4_RS13420	COG4536	flavin adenine dinucleotide binding
K10K4_RS13425	COG1854	S-ribosylhomocysteine lyase activity
K10K4_RS13440	COG0612	Peptidase, M16
K10K4_RS13445	COG1238	metal cluster binding
K10K4_RS13455	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
K10K4_RS13460	COG0511	ligase activity, forming carbon-carbon bonds
K10K4_RS13460	COG5016	pyruvate
K10K4_RS13465	COG3630	sodium ion export across plasma membrane
K10K4_RS13525	COG0527	aspartate kinase activity
K10K4_RS13530	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K10K4_RS13535	COG2137	regulation of response to DNA damage stimulus
K10K4_RS13540	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K10K4_RS13545	COG1546	Belongs to the CinA family
K10K4_RS13550	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K10K4_RS13555	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K10K4_RS13565	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K10K4_RS13570	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
K10K4_RS13580	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
K10K4_RS13585	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
K10K4_RS13590	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
K10K4_RS13595	COG0148	phosphopyruvate hydratase activity
K10K4_RS13600	COG0504	CTP synthase activity
K10K4_RS13605	COG3956	TIGRFAM MazG family protein
K10K4_RS13610	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K10K4_RS13615	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K10K4_RS13630	COG0736	holo-[acyl-carrier-protein] synthase activity
K10K4_RS13635	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
K10K4_RS13640	COG1381	Involved in DNA repair and RecF pathway recombination
K10K4_RS13645	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K10K4_RS13655	COG0681	Belongs to the peptidase S26 family
K10K4_RS13660	COG0481	GTPase activity
K10K4_RS13665	COG3086	response to oxidative stress
K10K4_RS13680	COG1595	DNA-templated transcription, initiation
K10K4_RS13685	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
K10K4_RS13695	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
K10K4_RS13715	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K10K4_RS13720	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K10K4_RS13725	COG3079	Belongs to the UPF0149 family
K10K4_RS13730	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
K10K4_RS13740	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K10K4_RS13745	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
K10K4_RS13750	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K10K4_RS13760	COG0583	DNA-binding transcription factor activity
K10K4_RS13775	COG0668	transmembrane transport
K10K4_RS13780	COG0191	fructose-bisphosphate aldolase activity
K10K4_RS13795	COG4771	TonB-dependent receptor
K10K4_RS13800	COG0583	DNA-binding transcription factor activity
K10K4_RS13805	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K10K4_RS13815	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K10K4_RS13825	COG3091	SprT-like family
K10K4_RS13830	COG2356	endonuclease I
K10K4_RS13835	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K10K4_RS13840	COG0189	ligase activity
K10K4_RS13845	COG1678	Uncharacterized ACR, COG1678
K10K4_RS13850	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K10K4_RS13865	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K10K4_RS13870	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K10K4_RS13875	COG0762	integral membrane protein
K10K4_RS13880	COG1872	DUF167
K10K4_RS13890	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
K10K4_RS13895	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K10K4_RS13900	COG2066	Belongs to the glutaminase family
K10K4_RS13910	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K10K4_RS13920	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
K10K4_RS13965	COG0840	transmembrane signaling receptor activity
K10K4_RS14045	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
K10K4_RS14050	COG1609	Transcriptional regulator
K10K4_RS14055	COG3394	polysaccharide catabolic process
K10K4_RS14060	COG1486	melibiose metabolic process
K10K4_RS14065	COG1447	Phosphotransferase system cellobiose-specific component IIA
K10K4_RS14070	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K10K4_RS14075	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K10K4_RS14080	COG0726	polysaccharide deacetylase
K10K4_RS14090	COG1028	Short-chain dehydrogenase reductase Sdr
K10K4_RS14105	COG0795	lipopolysaccharide-transporting ATPase activity
K10K4_RS14110	COG0795	lipopolysaccharide-transporting ATPase activity
K10K4_RS14115	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K10K4_RS14120	COG2927	DNA polymerase III (CHI subunit)
K10K4_RS14125	COG0525	valine-tRNA ligase activity
K10K4_RS14135	COG0456	acetyltransferase
K10K4_RS14165	COG0540	Belongs to the ATCase OTCase family
K10K4_RS14170	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
K10K4_RS14175	COG0251	oxidation-reduction process
K10K4_RS14180	COG0204	Acyl-transferase
K10K4_RS14185	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K10K4_RS14190	COG5007	Belongs to the BolA IbaG family
K10K4_RS14200	COG2854	intermembrane phospholipid transfer
K10K4_RS14205	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K10K4_RS14210	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K10K4_RS14215	COG1127	ABC transporter
K10K4_RS14225	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
K10K4_RS14225	COG0517	IMP dehydrogenase activity
K10K4_RS14235	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
K10K4_RS14240	COG1137	ATPase activity
K10K4_RS14250	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K10K4_RS14255	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K10K4_RS14260	COG1660	Displays ATPase and GTPase activities
K10K4_RS14265	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K10K4_RS14270	COG2239	Acts as a magnesium transporter
K10K4_RS14275	COG0312	modulator of DNA gyrase
K10K4_RS14280	COG3028	Belongs to the UPF0307 family
K10K4_RS14285	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K10K4_RS14290	COG0564	pseudouridine synthase activity
K10K4_RS14300	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K10K4_RS14305	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
K10K4_RS14310	COG0312	modulator of DNA gyrase
K10K4_RS14315	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K10K4_RS14320	COG3164	Protein of unknown function
K10K4_RS14330	COG0424	maF-like protein
K10K4_RS14335	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
K10K4_RS14340	COG1792	Involved in formation and maintenance of cell shape
K10K4_RS14345	COG1077	Cell shape determining protein MreB Mrl
K10K4_RS14380	COG2165	general secretion pathway protein
K10K4_RS14390	COG1459	type II secretion system
K10K4_RS14395	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K10K4_RS14405	COG3267	Type II secretory pathway component ExeA
K10K4_RS14405	COG3409	Peptidoglycan-binding domain 1 protein
K10K4_RS14410	COG1450	Type ii and iii secretion system protein
K10K4_RS14430	COG2199	diguanylate cyclase activity
K10K4_RS14430	COG2200	EAL domain
K10K4_RS14435	COG0629	single-stranded DNA binding
K10K4_RS14485	COG0424	maF-like protein
K10K4_RS14490	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
K10K4_RS14495	COG1792	Involved in formation and maintenance of cell shape
K10K4_RS14500	COG1077	Cell shape determining protein MreB Mrl
K10K4_RS14530	COG2165	general secretion pathway protein
K10K4_RS14540	COG1459	type II secretion system
K10K4_RS14545	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K10K4_RS14555	COG3409	Peptidoglycan-binding domain 1 protein
K10K4_RS14555	COG3267	Type II secretory pathway component ExeA
K10K4_RS14560	COG1450	Type ii and iii secretion system protein
K10K4_RS14580	COG2199	diguanylate cyclase activity
K10K4_RS14580	COG2200	EAL domain
K10K4_RS14585	COG0629	single-stranded DNA binding
K10K4_RS14600	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K10K4_RS14615	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
K10K4_RS14625	COG0527	aspartate kinase activity
K10K4_RS14630	COG1410	methionine synthase
K10K4_RS14630	COG0646	methionine synthase
K10K4_RS14700	COG0175	sulfate reduction
K10K4_RS14705	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K10K4_RS14710	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K10K4_RS14730	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K10K4_RS14735	COG0735	belongs to the Fur family
K10K4_RS14745	COG0166	Belongs to the GPI family
K10K4_RS14750	COG0432	Pfam Uncharacterised protein family UPF0047
K10K4_RS14755	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K10K4_RS14780	COG2965	DNA replication, synthesis of RNA primer
K10K4_RS14785	COG0360	Binds together with S18 to 16S ribosomal RNA
K10K4_RS14790	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K10K4_RS14795	COG0338	D12 class N6 adenine-specific DNA methyltransferase
K10K4_RS14805	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K10K4_RS14810	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K10K4_RS14840	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
K10K4_RS14850	COG0678	peroxiredoxin activity
K10K4_RS14850	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K10K4_RS14855	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K10K4_RS14870	COG0165	Argininosuccinate lyase
K10K4_RS14870	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
K10K4_RS14875	COG0137	argininosuccinate synthase activity
K10K4_RS14885	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
K10K4_RS14895	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
K10K4_RS14905	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K10K4_RS14910	COG0527	aspartate kinase activity
K10K4_RS14910	COG0460	homoserine dehydrogenase
K10K4_RS14915	COG0626	cystathionine gamma-synthase activity
K10K4_RS14920	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
K10K4_RS14925	COG0281	malic enzyme
K10K4_RS14940	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K10K4_RS14945	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K10K4_RS14965	COG2923	Belongs to the DsrF TusC family
K10K4_RS14970	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
K10K4_RS14975	COG2964	Protein conserved in bacteria
K10K4_RS14980	COG0545	Peptidyl-prolyl cis-trans isomerase
K10K4_RS14995	COG1446	asparaginase
K10K4_RS15005	COG1047	Peptidyl-prolyl cis-trans
K10K4_RS15020	COG2249	NAD(P)H dehydrogenase (quinone) activity
K10K4_RS15025	COG0488	(ABC) transporter
K10K4_RS15035	COG0429	hydrolase of the alpha beta-hydrolase fold
K10K4_RS15045	COG3954	Phosphoribulokinase
K10K4_RS15050	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K10K4_RS15070	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K10K4_RS15075	COG0512	Glutamine amidotransferase of anthranilate synthase
K10K4_RS15090	COG0180	Tryptophanyl-tRNA synthetase
K10K4_RS15095	COG0546	phosphoglycolate phosphatase activity
K10K4_RS15100	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K10K4_RS15105	COG0557	exoribonuclease II activity
K10K4_RS15110	COG1959	2 iron, 2 sulfur cluster binding
K10K4_RS15115	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K10K4_RS15115	COG1017	nitric oxide dioxygenase activity
K10K4_RS15120	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
K10K4_RS15125	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K10K4_RS15130	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
K10K4_RS15135	COG0330	HflC and HflK could
K10K4_RS15140	COG0330	HflC and HflK could
K10K4_RS15145	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K10K4_RS15155	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K10K4_RS15160	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K10K4_RS15170	COG0802	atpase or kinase
K10K4_RS15180	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K10K4_RS15245	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
K10K4_RS15250	COG1162	GTPase activity
K10K4_RS15255	COG0688	phosphatidylethanolamine metabolic process
K10K4_RS15260	COG0471	metal ion transport
K10K4_RS15270	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
K10K4_RS15275	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K10K4_RS15280	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
K10K4_RS15285	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K10K4_RS15290	COG1045	serine acetyltransferase
K10K4_RS15295	COG4942	peptidase
K10K4_RS15315	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
K10K4_RS15320	COG1053	succinate dehydrogenase
K10K4_RS15325	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K10K4_RS15330	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
K10K4_RS15335	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
K10K4_RS15350	COG1509	lysine 2,3-aminomutase activity
K10K4_RS15355	COG1285	pathogenesis
K10K4_RS15365	COG0459	protein refolding
K10K4_RS15380	COG0534	Mate efflux family protein
K10K4_RS15385	COG0205	6-phosphofructokinase activity
K10K4_RS15395	COG3678	ATP-independent chaperone mediated protein folding
K10K4_RS15400	COG0745	RESPONSE REGULATOR receiver
K10K4_RS15405	COG2205	protein histidine kinase activity
K10K4_RS15415	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
K10K4_RS15420	COG3030	protein affecting phage T7 exclusion by the F plasmid
K10K4_RS15425	COG1027	Aspartate ammonia-lyase
K10K4_RS15430	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
K10K4_RS15435	COG4232	protein-disulfide reductase activity
K10K4_RS15445	COG3263	regulation of cellular component size
K10K4_RS15455	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K10K4_RS15480	COG2814	Major facilitator Superfamily
K10K4_RS15495	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K10K4_RS15500	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K10K4_RS15505	COG0511	ligase activity, forming carbon-carbon bonds
K10K4_RS15510	COG0439	Biotin carboxylase
K10K4_RS15515	COG2264	protein methyltransferase activity
K10K4_RS15520	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K10K4_RS15525	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
K10K4_RS15535	COG0488	(ABC) transporter
K10K4_RS15585	COG1982	Orn Lys Arg decarboxylase major
K10K4_RS15590	COG0531	amino acid
K10K4_RS15600	COG3710	Transcriptional regulator
K10K4_RS15605	COG0789	Transcriptional regulator
K10K4_RS15620	COG0151	Belongs to the GarS family
K10K4_RS15635	COG1253	flavin adenine dinucleotide binding
K10K4_RS15640	COG3068	Protein conserved in bacteria
K10K4_RS15650	COG1573	uracil-dna glycosylase
K10K4_RS15655	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K10K4_RS15660	COG2816	NAD+ diphosphatase activity
K10K4_RS15665	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
K10K4_RS15670	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K10K4_RS15675	COG0085	RNA polymerase activity
K10K4_RS15680	COG0222	ribosome binding
K10K4_RS15685	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K10K4_RS15700	COG0250	Participates in transcription elongation, termination and antitermination
K10K4_RS15705	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K10K4_RS15715	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K10K4_RS15750	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
K10K4_RS15750	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
K10K4_RS15755	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K10K4_RS15765	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K10K4_RS15840	COG4206	TonB-dependent receptor
K10K4_RS15860	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K10K4_RS15865	COG0534	Mate efflux family protein
K10K4_RS15870	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
K10K4_RS15880	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K10K4_RS15890	COG2937	Belongs to the GPAT DAPAT family
K10K4_RS15895	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
K10K4_RS15900	COG3161	chorismate lyase activity
K10K4_RS15905	COG1580	Controls the rotational direction of flagella during chemotaxis
K10K4_RS15910	COG0705	Rhomboid family
K10K4_RS15915	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K10K4_RS15930	COG2177	Part of the ABC transporter FtsEX involved in
K10K4_RS15935	COG2884	Cell division ATP-binding protein ftsE
K10K4_RS15940	COG0552	protein localization to endoplasmic reticulum
K10K4_RS15945	COG0742	ribosomal rna small subunit methyltransferase
K10K4_RS15955	COG2095	MarC family integral membrane protein
K10K4_RS16000	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K10K4_RS16005	COG0640	Transcriptional regulator
K10K4_RS16010	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
K10K4_RS16015	COG1280	lysine exporter protein (LysE YggA)
K10K4_RS16020	COG2267	carboxylic ester hydrolase activity
K10K4_RS16025	COG0561	phosphatase activity
K10K4_RS16040	COG3148	PFAM DTW domain containing protein
K10K4_RS16045	COG2199	diguanylate cyclase activity
K10K4_RS16045	COG2200	EAL domain
K10K4_RS16045	COG3287	FIST C domain
K10K4_RS16050	COG1011	Hydrolase
K10K4_RS16055	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
K10K4_RS16070	COG0019	diaminopimelate decarboxylase activity
K10K4_RS16080	COG1965	Belongs to the frataxin family
K10K4_RS16085	COG3072	Adenylate cyclase
K10K4_RS16090	COG0181	hydroxymethylbilane synthase activity
K10K4_RS16095	COG1587	Uroporphyrinogen-III synthase
K10K4_RS16100	COG2959	enzyme of heme biosynthesis
K10K4_RS16105	COG3071	HemY protein
K10K4_RS16145	COG0633	Ferredoxin
K10K4_RS16150	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
K10K4_RS16165	COG3118	belongs to the thioredoxin family
K10K4_RS16170	COG0513	Belongs to the DEAD box helicase family
K10K4_RS16175	COG0248	Ppx GppA phosphatase
K10K4_RS16185	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
K10K4_RS16195	COG0514	ATP-dependent DNA helicase (RecQ)
K10K4_RS16200	COG2962	Rard protein
K10K4_RS16210	COG1280	lysine exporter protein (LysE YggA)
K10K4_RS16215	COG0405	Gamma-glutamyltransferase
K10K4_RS16220	COG0210	DNA helicase
K10K4_RS16230	COG3220	belongs to the UPF0276 family
K10K4_RS16260	COG0006	proline dipeptidase activity
K10K4_RS16260	COG0006	proline dipeptidase activity
K10K4_RS16275	COG2104	thiamine diphosphate biosynthetic process
K10K4_RS16280	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K10K4_RS16300	COG2132	Multicopper oxidase
K10K4_RS16350	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
K10K4_RS16370	COG0009	L-threonylcarbamoyladenylate synthase
K10K4_RS16375	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
K10K4_RS16380	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K10K4_RS16385	COG0551	DNA topoisomerase type I activity
K10K4_RS16390	COG2922	Belongs to the Smg family
K10K4_RS16395	COG0758	DNA mediated transformation
K10K4_RS16405	COG0242	peptide deformylase activity
K10K4_RS16410	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K10K4_RS16415	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K10K4_RS16415	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K10K4_RS16420	COG0569	domain protein
K10K4_RS16425	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K10K4_RS16435	COG1272	protein, Hemolysin III
K10K4_RS16440	COG4326	sporulation control protein
K10K4_RS16450	COG3084	Protein conserved in bacteria
K10K4_RS16460	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
K10K4_RS16465	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K10K4_RS16470	COG0204	Acyl-transferase
K10K4_RS16480	COG0606	chelatase, subunit chli
K10K4_RS16490	COG3978	acetolactate synthase activity
K10K4_RS16495	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K10K4_RS16500	COG0129	dihydroxy-acid dehydratase activity
K10K4_RS16510	COG0583	DNA-binding transcription factor activity
K10K4_RS16515	COG2814	Major facilitator Superfamily
K10K4_RS16525	COG0765	amino acid transport
K10K4_RS16535	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K10K4_RS16540	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K10K4_RS16545	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K10K4_RS16550	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K10K4_RS16555	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K10K4_RS16560	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K10K4_RS16570	COG0356	it plays a direct role in the translocation of protons across the membrane
K10K4_RS16575	COG3312	ion transport
K10K4_RS16580	COG1475	DNA binding
K10K4_RS16585	COG1192	Involved in chromosome partitioning
K10K4_RS16590	COG0357	Ribosomal RNA small subunit methyltransferase G
K10K4_RS16595	COG0445	tRNA wobble uridine modification
K10K4_RS16600	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K10K4_RS16610	COG0706	membrane insertase activity
K10K4_RS16620	COG0594	ribonuclease P activity
K10K4_RS16630	COG1126	abc transporter atp-binding protein
K10K4_RS16655	COG1444	tRNA N-acetyltransferase activity
K10K4_RS16675	COG3340	Belongs to the peptidase S51 family
K10K4_RS16680	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K10K4_RS16685	COG1263	PTS System
K10K4_RS16685	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K10K4_RS16690	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
K10K4_RS16705	COG4166	transmembrane transport
K10K4_RS16750	COG0259	pyridoxamine-phosphate oxidase activity
K10K4_RS16775	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K10K4_RS16815	COG1132	(ABC) transporter
K10K4_RS16825	COG0513	Belongs to the DEAD box helicase family
K10K4_RS16830	COG2258	MOSC domain
K10K4_RS16885	COG3634	alkyl hydroperoxide reductase activity
K10K4_RS16930	COG1846	Transcriptional regulator
K10K4_RS16935	COG1764	response to oxidative stress
K10K4_RS16970	COG0577	efflux transmembrane transporter activity
K10K4_RS16975	COG1136	(ABC) transporter
K10K4_RS16990	COG0826	peptidase U32
K10K4_RS17015	COG1653	transport
K10K4_RS17020	COG0019	diaminopimelate decarboxylase activity
K10K4_RS17025	COG4264	IucA IucC family
K10K4_RS17050	COG4772	TonB-dependent receptor
K10K4_RS17055	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
K10K4_RS17060	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K10K4_RS17065	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K10K4_RS17070	COG1120	ATPase activity
K10K4_RS17075	COG0840	transmembrane signaling receptor activity
K10K4_RS17080	COG0612	Peptidase, M16
K10K4_RS17090	COG0739	heme binding
K10K4_RS17105	COG2814	Major facilitator Superfamily
K10K4_RS17115	COG1609	Transcriptional regulator
K10K4_RS17120	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K10K4_RS17140	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K10K4_RS17140	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K10K4_RS17150	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K10K4_RS17155	COG1609	Transcriptional regulator
K10K4_RS17165	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K10K4_RS17180	COG0596	Alpha beta hydrolase
K10K4_RS17205	COG1760	l-serine dehydratase
K10K4_RS17215	COG4580	involved in the transport of maltose and maltodextrins
K10K4_RS17235	COG2356	endonuclease I
K10K4_RS17255	COG1982	Orn Lys Arg decarboxylase major
K10K4_RS17260	COG0531	amino acid
K10K4_RS17270	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
K10K4_RS17275	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
K10K4_RS17280	COG1162	GTPase activity
K10K4_RS17285	COG1263	PTS System
K10K4_RS17285	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K10K4_RS17290	COG1999	signal sequence binding
K10K4_RS17305	COG2909	trisaccharide binding
K10K4_RS17315	COG0058	SHG alpha-glucan phosphorylase activity
K10K4_RS17320	COG1640	4-alpha-glucanotransferase
K10K4_RS17325	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
K10K4_RS17330	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K10K4_RS17335	COG0366	Alpha amylase catalytic
K10K4_RS17350	COG3366	ferrous iron transmembrane transporter activity
K10K4_RS17355	COG0700	Nucleoside recognition
K10K4_RS17360	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K10K4_RS17365	COG3339	Conserved Protein
K10K4_RS17370	COG1301	dicarboxylic acid transport
K10K4_RS17380	COG0583	DNA-binding transcription factor activity
K10K4_RS17400	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K10K4_RS17405	COG1596	polysaccharide export
K10K4_RS17420	COG2095	MarC family integral membrane protein
K10K4_RS17425	COG4667	esterase of the alpha-beta hydrolase superfamily
K10K4_RS17430	COG3397	chitin binding
K10K4_RS17435	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
K10K4_RS17440	COG0415	Belongs to the DNA photolyase family
K10K4_RS17450	COG1054	Belongs to the UPF0176 family
K10K4_RS17460	COG1686	Belongs to the peptidase S11 family
K10K4_RS17485	COG0583	DNA-binding transcription factor activity
K10K4_RS17490	COG4628	conserved protein (DUF2132)
K10K4_RS17510	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
K10K4_RS17515	COG0628	permease
K10K4_RS17540	COG1289	transmembrane transporter activity
K10K4_RS17560	COG2814	Major facilitator Superfamily
K10K4_RS17570	COG0454	-acetyltransferase
K10K4_RS17580	COG0745	RESPONSE REGULATOR receiver
K10K4_RS17585	COG2205	protein histidine kinase activity
K10K4_RS17600	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K10K4_RS17605	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K10K4_RS17610	COG1882	Formate acetyltransferase
K10K4_RS17645	COG1360	Flagellar Motor Protein
K10K4_RS17650	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K10K4_RS17655	COG1191	sigma factor activity
K10K4_RS17660	COG1580	Controls the rotational direction of flagella during chemotaxis
K10K4_RS17675	COG1516	flagellar protein fliS
K10K4_RS17680	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
K10K4_RS17690	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K10K4_RS17705	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K10K4_RS17715	COG1987	bacterial-type flagellum assembly
K10K4_RS17755	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K10K4_RS17815	COG0346	lactoylglutathione lyase activity
K10K4_RS17840	COG0745	RESPONSE REGULATOR receiver
K10K4_RS17865	COG5001	Diguanylate cyclase
K10K4_RS17865	COG3300	MHYT domain
K10K4_RS17870	COG0156	8-amino-7-oxononanoate synthase activity
K10K4_RS17875	COG1063	alcohol dehydrogenase
K10K4_RS17910	COG0668	transmembrane transport
K10K4_RS17920	COG1304	FMN binding
K10K4_RS17925	COG1620	l-lactate permease
K10K4_RS17930	COG0583	DNA-binding transcription factor activity
K10K4_RS17935	COG1505	serine-type exopeptidase activity
K10K4_RS17940	COG4172	Belongs to the ABC transporter superfamily
K10K4_RS17950	COG1067	ATP-dependent peptidase activity
K10K4_RS17960	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K10K4_RS17980	COG1247	-acetyltransferase
K10K4_RS17985	COG0437	4 iron, 4 sulfur cluster binding
K10K4_RS17990	COG0348	domain, Protein
K10K4_RS18010	COG1122	ATPase activity
K10K4_RS18015	COG4720	Psort location CytoplasmicMembrane, score
K10K4_RS18020	COG1566	PFAM secretion protein HlyD family protein
K10K4_RS18045	COG0813	purine-nucleoside phosphorylase activity
K10K4_RS18050	COG3272	Protein of unknown function (DUF1722)
K10K4_RS18055	COG0789	Transcriptional regulator
K10K4_RS18060	COG0415	Belongs to the DNA photolyase family
K10K4_RS18065	COG1376	ErfK ybiS ycfS ynhG family protein
K10K4_RS18065	COG1388	LysM domain
K10K4_RS18075	COG0513	Belongs to the DEAD box helicase family
K10K4_RS18080	COG1770	oligopeptidase
K10K4_RS18085	COG4771	TonB-dependent receptor
K10K4_RS18115	COG0573	inorganic phosphate transmembrane transporter activity
K10K4_RS18120	COG0581	inorganic phosphate transmembrane transporter activity
K10K4_RS18125	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K10K4_RS18140	COG2304	oxidoreductase activity
K10K4_RS18160	COG0714	Associated with various cellular activities
K10K4_RS18175	COG2197	response regulator
K10K4_RS18210	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
K10K4_RS18215	COG1120	ATPase activity
K10K4_RS18220	COG4774	siderophore transport
K10K4_RS18225	COG1132	(ABC) transporter
K10K4_RS18230	COG2205	protein histidine kinase activity
K10K4_RS18240	COG0569	domain protein
K10K4_RS18245	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K10K4_RS18250	COG0583	DNA-binding transcription factor activity
K10K4_RS18265	COG1012	belongs to the aldehyde dehydrogenase family
K10K4_RS18270	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K10K4_RS18275	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K10K4_RS18285	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
K10K4_RS18290	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K10K4_RS18320	COG2084	Dehydrogenase
K10K4_RS18325	COG0753	catalase activity
K10K4_RS18335	COG2130	NADP-dependent
K10K4_RS18340	COG1309	transcriptional regulator
K10K4_RS18345	COG3097	Belongs to the UPF0267 family
K10K4_RS18385	COG0489	protein tyrosine kinase activity
K10K4_RS18385	COG3206	protein involved in exopolysaccharide biosynthesis
K10K4_RS18400	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K10K4_RS18405	COG3842	ATPase activity
K10K4_RS18415	COG1175	transmembrane transport
K10K4_RS18420	COG3833	ABC-type maltose transport systems, permease component
K10K4_RS18450	COG2354	Protein conserved in bacteria
K10K4_RS18455	COG0418	dihydroorotase activity
K10K4_RS18465	COG0401	homolog of Blt101
K10K4_RS18470	COG0633	Ferredoxin
K10K4_RS18470	COG0633	Ferredoxin
K10K4_RS18470	COG3217	Mosc domain protein beta barrel domain protein
K10K4_RS18470	COG3217	Mosc domain protein beta barrel domain protein
K10K4_RS18480	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K10K4_RS18520	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
K10K4_RS18525	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K10K4_RS18535	COG0848	biopolymer transport protein
K10K4_RS18540	COG0811	peptide transport
K10K4_RS18545	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
K10K4_RS18555	COG3721	Heme iron utilization protein
K10K4_RS18560	COG0748	coenzyme F420 binding
K10K4_RS18570	COG0835	chemotaxis
K10K4_RS18570	COG0784	Response regulator, receiver
K10K4_RS18575	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K10K4_RS18580	COG0534	Mate efflux family protein
K10K4_RS18585	COG0444	Belongs to the ABC transporter superfamily
K10K4_RS18590	COG4608	Belongs to the ABC transporter superfamily
K10K4_RS18595	COG0747	negative chemotaxis
K10K4_RS18605	COG1349	DNA-binding transcription factor activity
K10K4_RS18610	COG2084	Dehydrogenase
K10K4_RS18615	COG3395	kinase activity
K10K4_RS18620	COG0235	Class ii aldolase
K10K4_RS18625	COG3622	Belongs to the hyi family
K10K4_RS18630	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K10K4_RS18635	COG2610	gluconate transmembrane transporter activity
K10K4_RS18655	COG0583	DNA-binding transcription factor activity
K10K4_RS18660	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K10K4_RS18670	COG4934	collagen metabolic process
K10K4_RS18680	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K10K4_RS18685	COG0789	Transcriptional regulator
K10K4_RS18690	COG0366	Alpha amylase catalytic
K10K4_RS18710	COG2249	NAD(P)H dehydrogenase (quinone) activity
K10K4_RS18715	COG0589	response to stress
K10K4_RS18720	COG0488	(ABC) transporter
K10K4_RS18725	COG1505	serine-type exopeptidase activity
K10K4_RS18735	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K10K4_RS18745	COG2067	long-chain fatty acid transport protein
K10K4_RS18755	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K10K4_RS18780	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K10K4_RS18800	COG3383	formate dehydrogenase (NAD+) activity
K10K4_RS18810	COG0842	Transport permease protein
K10K4_RS18815	COG1131	(ABC) transporter
K10K4_RS18835	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
K10K4_RS18845	COG4145	pantothenate transmembrane transporter activity
K10K4_RS18850	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K10K4_RS18855	COG0800	Aldolase
K10K4_RS18865	COG2706	6-phosphogluconolactonase activity
K10K4_RS18870	COG0251	oxidation-reduction process
K10K4_RS18880	COG1881	PFAM PEBP family protein
K10K4_RS18890	COG0798	PFAM Bile acid sodium symporter
K10K4_RS18905	COG1733	regulation of RNA biosynthetic process
K10K4_RS18930	COG4989	oxidoreductase activity
K10K4_RS18955	COG0814	amino acid
K10K4_RS18970	COG3314	Sporulation integral membrane protein YlbJ
K10K4_RS18990	COG0739	heme binding
K10K4_RS18995	COG5001	Diguanylate cyclase
K10K4_RS19000	COG0583	DNA-binding transcription factor activity
K10K4_RS19005	COG2814	Major facilitator Superfamily
K10K4_RS19025	COG0697	spore germination
K10K4_RS19040	COG0179	Fumarylacetoacetate (FAA) hydrolase
K10K4_RS19060	COG1280	lysine exporter protein (LysE YggA)
K10K4_RS19070	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K10K4_RS19075	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K10K4_RS19080	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K10K4_RS19085	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
K10K4_RS19090	COG1845	cytochrome c oxidase, subunit III
K10K4_RS19110	COG1612	heme a metabolic process
K10K4_RS19115	COG0109	protoheme IX farnesyltransferase activity
K10K4_RS19120	COG0545	Peptidyl-prolyl cis-trans isomerase
K10K4_RS19150	COG1278	Cold shock
K10K4_RS19155	COG3036	rescue of stalled ribosome
K10K4_RS19160	COG2199	diguanylate cyclase activity
K10K4_RS19175	COG1132	(ABC) transporter
K10K4_RS19180	COG1132	(ABC) transporter
K10K4_RS19185	COG1538	Outer membrane efflux protein
K10K4_RS19190	COG0784	Response regulator, receiver
K10K4_RS19190	COG2205	protein histidine kinase activity
K10K4_RS19215	COG0840	transmembrane signaling receptor activity
K10K4_RS19220	COG0783	Belongs to the Dps family
K10K4_RS19230	COG2133	pyrroloquinoline quinone binding
K10K4_RS19235	COG1454	alcohol dehydrogenase
K10K4_RS19240	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
K10K4_RS19260	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K10K4_RS19265	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K10K4_RS19270	COG3186	Phenylalanine-4-hydroxylase
K10K4_RS19295	COG3530	Putative quorum-sensing-regulated virulence factor
K10K4_RS19315	COG0513	Belongs to the DEAD box helicase family
K10K4_RS19320	COG4628	conserved protein (DUF2132)
K10K4_RS19330	COG0133	tryptophan synthase activity
K10K4_RS19340	COG1278	Cold shock
K10K4_RS19350	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
K10K4_RS19360	COG0523	cobalamin synthesis protein
K10K4_RS19365	COG0513	Belongs to the DEAD box helicase family
K10K4_RS19385	COG2200	EAL domain
K10K4_RS19390	COG1119	ATPase activity
K10K4_RS19425	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
K10K4_RS19430	COG0513	Belongs to the DEAD box helicase family
K10K4_RS19445	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K10K4_RS19455	COG1073	alpha beta
K10K4_RS19460	COG1073	alpha beta
K10K4_RS19475	COG0730	response to heat
K10K4_RS19495	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K10K4_RS19505	COG0523	cobalamin synthesis protein
K10K4_RS19510	COG2988	succinylglutamate desuccinylase activity
K10K4_RS19515	COG0739	heme binding
K10K4_RS19525	COG0523	cobalamin synthesis protein
K10K4_RS19545	COG2095	MarC family integral membrane protein
K10K4_RS19570	COG1024	Enoyl-CoA hydratase
K10K4_RS19575	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K10K4_RS19580	COG1960	acyl-CoA dehydrogenase activity
K10K4_RS19590	COG0183	Belongs to the thiolase family
K10K4_RS19605	COG1024	Enoyl-CoA hydratase
K10K4_RS19610	COG1024	Enoyl-CoA hydratase
K10K4_RS19620	COG1028	Short-chain dehydrogenase reductase Sdr
K10K4_RS19625	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K10K4_RS19630	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K10K4_RS19635	COG1845	cytochrome c oxidase, subunit III
K10K4_RS19640	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
K10K4_RS19645	COG0109	protoheme IX farnesyltransferase activity
K10K4_RS19650	COG0446	pyridine nucleotide-disulphide oxidoreductase
K10K4_RS19650	COG1902	pentaerythritol trinitrate reductase activity
K10K4_RS19665	COG1012	belongs to the aldehyde dehydrogenase family
K10K4_RS19675	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K10K4_RS19705	COG1126	abc transporter atp-binding protein
K10K4_RS19710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K10K4_RS19715	COG4215	(ABC) transporter
K10K4_RS19720	COG4160	amino acid transport
K10K4_RS19785	COG0443	Heat shock 70 kDa protein
K10K4_RS19790	COG2847	Copper chaperone PCu(A)C
K10K4_RS19855	COG0814	amino acid
K10K4_RS19865	COG0243	molybdopterin cofactor binding
K10K4_RS19895	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K10K4_RS19895	COG1116	anion transmembrane transporter activity
K10K4_RS19900	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K10K4_RS19905	COG1116	anion transmembrane transporter activity
K10K4_RS19910	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K10K4_RS19910	COG2146	nitrite reductase [NAD(P)H] activity
K10K4_RS19960	COG2815	serine threonine protein kinase
K10K4_RS19960	COG0515	serine threonine protein kinase
K10K4_RS19995	COG0631	protein serine/threonine phosphatase activity
K10K4_RS20065	COG0420	3'-5' exonuclease activity
K10K4_RS20070	COG0419	ATPase involved in DNA repair
K10K4_RS20080	COG3040	lipid binding
K10K4_RS20090	COG1288	antiporter activity
K10K4_RS20100	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
K10K4_RS20115	COG2425	protein containing a von Willebrand factor type A (vWA) domain
K10K4_RS20130	COG0583	DNA-binding transcription factor activity
K10K4_RS20135	COG0277	FAD linked oxidase domain protein
K10K4_RS20150	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K10K4_RS20185	COG2176	DNA-directed DNA polymerase activity
K10K4_RS20230	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
K10K4_RS20235	COG1328	CTP reductase activity
K10K4_RS20435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K10K4_RS20460	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K10K4_RS20465	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K10K4_RS20475	COG2116	formate transmembrane transporter activity
K10K4_RS20495	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
K10K4_RS20535	COG3118	belongs to the thioredoxin family
K10K4_RS20540	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K10K4_RS20565	COG2271	Major facilitator Superfamily
K10K4_RS20570	COG3851	Histidine kinase
K10K4_RS20575	COG2197	response regulator
K10K4_RS20585	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K10K4_RS20590	COG0583	DNA-binding transcription factor activity
K10K4_RS20600	COG0243	molybdopterin cofactor binding
K10K4_RS20615	COG0384	phenazine biosynthesis protein PhzF
K10K4_RS20620	COG1794	racemase activity, acting on amino acids and derivatives
K10K4_RS20650	COG1328	CTP reductase activity
K10K4_RS20655	COG0602	queuosine metabolic process
K10K4_RS20660	COG0534	Mate efflux family protein
K10K4_RS20665	COG2207	Transcriptional regulator
K10K4_RS20675	COG4067	protein conserved in archaea
K10K4_RS20675	COG0189	ligase activity
K10K4_RS20685	COG3111	PFAM Bacterial OB fold (BOF) protein
K10K4_RS20695	COG0725	ABC transporter, periplasmic molybdate-binding protein
K10K4_RS20700	COG4149	molybdate abc transporter
K10K4_RS20705	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
K10K4_RS20715	COG5001	Diguanylate cyclase
K10K4_RS20715	COG2203	Gaf domain
K10K4_RS20715	COG3706	GGDEF domain
K10K4_RS20715	COG4251	negative regulation of phosphorylation
K10K4_RS20735	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
K10K4_RS20740	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
K10K4_RS20765	COG3140	Belongs to the UPF0181 family
K10K4_RS20780	COG0583	DNA-binding transcription factor activity
K10K4_RS20930	COG0023	Translation Initiation Factor
K10K4_RS20940	COG1181	Belongs to the D-alanine--D-alanine ligase family
K10K4_RS20955	COG0045	succinate-CoA ligase (ADP-forming) activity
K10K4_RS20955	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K10K4_RS20955	COG1042	CoA-binding domain protein
K10K4_RS20960	COG0583	DNA-binding transcription factor activity
K10K4_RS20975	COG3447	MASE1 domain protein
K10K4_RS20975	COG5001	Diguanylate cyclase
K10K4_RS20975	COG5002	protein histidine kinase activity
K10K4_RS20980	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
K10K4_RS20985	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
K10K4_RS20990	COG1984	allophanate hydrolase subunit 2
K10K4_RS21035	COG4128	Pfam Zonular occludens toxin
K10K4_RS21110	COG1042	CoA-binding domain protein
K10K4_RS21110	COG0045	succinate-CoA ligase (ADP-forming) activity
K10K4_RS21110	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K10K4_RS21115	COG0583	DNA-binding transcription factor activity
K10K4_RS21130	COG3447	MASE1 domain protein
K10K4_RS21130	COG5001	Diguanylate cyclase
K10K4_RS21130	COG5002	protein histidine kinase activity
K10K4_RS21135	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
K10K4_RS21140	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
K10K4_RS21145	COG1984	allophanate hydrolase subunit 2
K10K4_RS21155	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
K10K4_RS21160	COG4181	ATPase activity
K10K4_RS21170	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K10K4_RS21175	COG5001	Diguanylate cyclase
K10K4_RS21175	COG3300	MHYT domain
K10K4_RS21210	COG4533	DNA binding
K10K4_RS21220	COG2050	protein possibly involved in aromatic compounds catabolism
K10K4_RS21235	COG2067	long-chain fatty acid transport protein
K10K4_RS21240	COG2267	carboxylic ester hydrolase activity
K10K4_RS21260	COG0861	Integral membrane protein TerC family
K10K4_RS21265	COG0737	Belongs to the 5'-nucleotidase family
K10K4_RS21270	COG3593	DNA synthesis involved in DNA repair
K10K4_RS21280	COG0583	DNA-binding transcription factor activity
K10K4_RS21285	COG2116	formate transmembrane transporter activity
K10K4_RS21290	COG2353	YceI-like domain
K10K4_RS21295	COG3038	cytochrome b561
K10K4_RS21315	COG0513	Belongs to the DEAD box helicase family
K10K4_RS21320	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
K10K4_RS21330	COG0840	transmembrane signaling receptor activity
K10K4_RS21340	COG0546	phosphoglycolate phosphatase activity
K10K4_RS21355	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K10K4_RS21360	COG2759	Belongs to the formate--tetrahydrofolate ligase family
K10K4_RS21365	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K10K4_RS21380	COG2207	Transcriptional regulator
K10K4_RS21385	COG1979	alcohol dehydrogenase
K10K4_RS21395	COG1126	abc transporter atp-binding protein
K10K4_RS21400	COG0765	amino acid transport
K10K4_RS21405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K10K4_RS21410	COG0765	amino acid transport
K10K4_RS21415	COG2200	EAL domain
K10K4_RS21415	COG2199	diguanylate cyclase activity
K10K4_RS21415	COG2203	Gaf domain
K10K4_RS21430	COG1609	Transcriptional regulator
K10K4_RS21435	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K10K4_RS21435	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K10K4_RS21440	COG1105	Belongs to the carbohydrate kinase PfkB family
K10K4_RS21445	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
K10K4_RS21445	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K10K4_RS21445	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K10K4_RS21475	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K10K4_RS21485	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K10K4_RS21490	COG0509	glycine decarboxylation via glycine cleavage system
K10K4_RS21500	COG0346	lactoylglutathione lyase activity
K10K4_RS21505	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K10K4_RS21510	COG0583	DNA-binding transcription factor activity
K10K4_RS21515	COG0697	spore germination
K10K4_RS21520	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K10K4_RS21550	COG2176	DNA-directed DNA polymerase activity
K10K4_RS21590	COG0242	peptide deformylase activity
K10K4_RS21625	COG2239	Acts as a magnesium transporter
K10K4_RS21645	COG0346	lactoylglutathione lyase activity
K10K4_RS21650	COG1902	pentaerythritol trinitrate reductase activity
K10K4_RS21660	COG2755	lipolytic protein G-D-S-L family
K10K4_RS21660	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K10K4_RS21670	COG5642	Protein of unknown function (DUF2384)
K10K4_RS21675	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
K10K4_RS21710	COG2076	Multidrug Resistance protein
K10K4_RS21730	COG2962	Rard protein
K10K4_RS21745	COG0835	chemotaxis
K10K4_RS21745	COG0784	Response regulator, receiver
K10K4_RS21755	COG2197	response regulator
K10K4_RS21765	COG3706	GGDEF domain
K10K4_RS21770	COG2197	response regulator
K10K4_RS21775	COG5001	Diguanylate cyclase
K10K4_RS21775	COG3300	MHYT domain
K10K4_RS21780	COG2205	protein histidine kinase activity
K10K4_RS21780	COG0784	Response regulator, receiver
K10K4_RS21785	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
K10K4_RS21805	COG0456	acetyltransferase
K10K4_RS21805	COG1214	PFAM Peptidase M22, glycoprotease
K10K4_RS21815	COG3069	C4-dicarboxylate transmembrane transporter activity
K10K4_RS21845	COG3111	PFAM Bacterial OB fold (BOF) protein
K10K4_RS21850	COG1597	lipid kinase activity
K10K4_RS21855	COG0583	DNA-binding transcription factor activity
K10K4_RS21860	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K10K4_RS21890	COG0714	Associated with various cellular activities
K10K4_RS21895	COG0641	radical SAM
K10K4_RS21900	COG3119	arylsulfatase activity
K10K4_RS21910	COG3119	arylsulfatase activity
K10K4_RS21915	COG0745	RESPONSE REGULATOR receiver
K10K4_RS21930	COG2205	protein histidine kinase activity
K10K4_RS21930	COG2198	Histidine kinase
K10K4_RS21930	COG0784	Response regulator, receiver
K10K4_RS21935	COG1879	ABC-type sugar transport system periplasmic component
K10K4_RS21940	COG1803	Methylglyoxal synthase
K10K4_RS21945	COG0210	DNA helicase
K10K4_RS21950	COG1289	transmembrane transporter activity
K10K4_RS21985	COG4771	TonB-dependent receptor
K10K4_RS21985	COG1629	transport
K10K4_RS21995	COG0789	Transcriptional regulator
K10K4_RS22000	COG4604	ABC transporter, ATP-binding protein
K10K4_RS22005	COG4605	iron ion homeostasis
K10K4_RS22010	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K10K4_RS22015	COG4607	ABC-type enterochelin transport system periplasmic component
K10K4_RS22025	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
K10K4_RS22040	COG1609	Transcriptional regulator
K10K4_RS22045	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K10K4_RS22050	COG1879	ABC-type sugar transport system periplasmic component
K10K4_RS22055	COG1172	Belongs to the binding-protein-dependent transport system permease family
K10K4_RS22060	COG1129	ABC transporter
K10K4_RS22065	COG1869	D-ribose catabolic process
K10K4_RS22070	COG5001	Diguanylate cyclase
K10K4_RS22125	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K10K4_RS22135	COG0784	Response regulator, receiver
K10K4_RS22135	COG2205	protein histidine kinase activity
K10K4_RS22150	COG0330	HflC and HflK could
K10K4_RS22165	COG0517	IMP dehydrogenase activity
K10K4_RS22165	COG4175	Glycine betaine
K10K4_RS22170	COG4176	ABC-type proline glycine betaine transport system permease component
K10K4_RS22185	COG1012	belongs to the aldehyde dehydrogenase family
K10K4_RS22190	COG1309	transcriptional regulator
K10K4_RS22200	COG1028	Short-chain dehydrogenase reductase Sdr
K10K4_RS22215	COG1024	Enoyl-CoA hydratase
K10K4_RS22220	COG1960	acyl-CoA dehydrogenase activity
K10K4_RS22230	COG0183	Belongs to the thiolase family
K10K4_RS22240	COG1960	acyl-CoA dehydrogenase activity
K10K4_RS22245	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K10K4_RS22255	COG4770	biotin carboxylase activity
K10K4_RS22270	COG3264	Mechanosensitive ion channel
K10K4_RS22270	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K10K4_RS22275	COG0110	maltose O-acetyltransferase activity
K10K4_RS22280	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K10K4_RS22285	COG1271	oxidase subunit
K10K4_RS22290	COG1294	oxidase, subunit
K10K4_RS22300	COG0384	phenazine biosynthesis protein PhzF
K10K4_RS22320	COG3527	Alpha-acetolactate decarboxylase
K10K4_RS22330	COG1028	Short-chain dehydrogenase reductase Sdr
K10K4_RS22335	COG0500	methyltransferase
K10K4_RS22365	COG1022	Amp-dependent synthetase and ligase
K10K4_RS22395	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K10K4_RS22400	COG1263	PTS System
K10K4_RS22400	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K10K4_RS22405	COG1486	melibiose metabolic process
K10K4_RS22410	COG2188	Transcriptional regulator
K10K4_RS22415	COG1320	monovalent cation:proton antiporter activity
K10K4_RS22420	COG2212	antiporter activity
K10K4_RS22425	COG1863	multisubunit Na H antiporter MnhE subunit
K10K4_RS22430	COG0651	ATP synthesis coupled electron transport
K10K4_RS22435	COG1006	Multisubunit Na H antiporter MnhC subunit
K10K4_RS22440	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K10K4_RS22440	COG2111	Na H antiporter
K10K4_RS22450	COG0589	response to stress
K10K4_RS22455	COG4221	oxidoreductase activity
K10K4_RS22460	COG0583	DNA-binding transcription factor activity
K10K4_RS22470	COG2814	Major facilitator Superfamily
K10K4_RS22535	COG1522	sequence-specific DNA binding
K10K4_RS22570	COG0515	serine threonine protein kinase
K10K4_RS22595	COG3501	Rhs element vgr protein
K10K4_RS22610	COG2204	response regulator
K10K4_RS22635	COG0739	heme binding
K10K4_RS22650	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K10K4_RS22700	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
K10K4_RS22710	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
K10K4_RS22710	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
K10K4_RS22725	COG4989	oxidoreductase activity
K10K4_RS22740	COG0038	chloride channel
K10K4_RS22775	COG2897	thiosulfate sulfurtransferase activity
K10K4_RS22795	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K10K4_RS22800	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K10K4_RS22805	COG0840	transmembrane signaling receptor activity
K10K4_RS22810	COG2814	Major facilitator Superfamily
K10K4_RS22815	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K10K4_RS22830	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K10K4_RS22840	COG0840	transmembrane signaling receptor activity
K10K4_RS22860	COG2195	Cleaves the N-terminal amino acid of tripeptides
K10K4_RS22875	COG2197	response regulator
K10K4_RS22880	COG3850	Histidine kinase
K10K4_RS22885	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K10K4_RS22895	COG0243	molybdopterin cofactor binding
K10K4_RS22905	COG3005	denitrification pathway
K10K4_RS22915	COG3243	poly(R)-hydroxyalkanoic acid synthase
K10K4_RS22925	COG0183	Belongs to the thiolase family
K10K4_RS22935	COG1280	lysine exporter protein (LysE YggA)
K10K4_RS22945	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K10K4_RS22950	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K10K4_RS23005	COG1846	Transcriptional regulator
K10K4_RS23010	COG0784	Response regulator, receiver
K10K4_RS23010	COG2205	protein histidine kinase activity
K10K4_RS23015	COG1879	ABC-type sugar transport system periplasmic component
K10K4_RS23025	COG2827	Endonuclease containing a URI domain
K10K4_RS23030	COG3132	Protein of unknown function, DUF480
K10K4_RS23050	COG0784	Response regulator, receiver
K10K4_RS23050	COG5002	protein histidine kinase activity
K10K4_RS23050	COG2205	protein histidine kinase activity
K10K4_RS23075	COG0583	DNA-binding transcription factor activity
K10K4_RS23085	COG0531	amino acid
K10K4_RS23100	COG2205	protein histidine kinase activity
K10K4_RS23105	COG0745	RESPONSE REGULATOR receiver
K10K4_RS23135	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K10K4_RS23140	COG2239	Acts as a magnesium transporter
K10K4_RS23145	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
K10K4_RS23150	COG0402	S-adenosylhomocysteine deaminase activity
K10K4_RS23155	COG1418	mRNA catabolic process
K10K4_RS23165	COG2814	Major facilitator Superfamily
K10K4_RS23175	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K10K4_RS23195	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K10K4_RS23210	COG0745	RESPONSE REGULATOR receiver
K10K4_RS23215	COG2205	protein histidine kinase activity
K10K4_RS23225	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K10K4_RS23230	COG2194	sulfuric ester hydrolase activity
K10K4_RS23250	COG4667	esterase of the alpha-beta hydrolase superfamily
K10K4_RS23255	COG1741	Belongs to the pirin family
K10K4_RS23260	COG1278	Cold shock
K10K4_RS23275	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K10K4_RS23280	COG0678	peroxiredoxin activity
K10K4_RS23280	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K10K4_RS23290	COG1686	Belongs to the peptidase S11 family
K10K4_RS23300	COG0625	glutathione transferase activity
K10K4_RS23310	COG1621	beta-fructofuranosidase activity
K10K4_RS23315	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K10K4_RS23320	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K10K4_RS23320	COG1263	PTS System
K10K4_RS23340	COG1028	Short-chain dehydrogenase reductase Sdr
K10K4_RS23355	COG3746	phosphate-selective porin O and P
K10K4_RS23370	COG0300	oxidoreductase activity
K10K4_RS23375	COG0583	DNA-binding transcription factor activity
K10K4_RS23380	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K10K4_RS23380	COG2207	Transcriptional regulator
K10K4_RS23385	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K10K4_RS23410	COG0513	Belongs to the DEAD box helicase family
K10K4_RS23420	COG0583	DNA-binding transcription factor activity
K10K4_RS23435	COG1902	pentaerythritol trinitrate reductase activity
K10K4_RS23440	COG1063	alcohol dehydrogenase
K10K4_RS23450	COG1028	Short-chain dehydrogenase reductase Sdr
K10K4_RS23460	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K10K4_RS23465	COG0006	proline dipeptidase activity
K10K4_RS23470	COG3608	succinylglutamate desuccinylase aspartoacylase
K10K4_RS23475	COG1522	sequence-specific DNA binding
K10K4_RS23480	COG1012	belongs to the aldehyde dehydrogenase family
K10K4_RS23485	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K10K4_RS23490	COG3122	Protein conserved in bacteria
K10K4_RS23505	COG0583	DNA-binding transcription factor activity
K10K4_RS23510	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K10K4_RS23515	COG0252	asparaginase activity
K10K4_RS23520	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
K10K4_RS23535	COG2197	response regulator
K10K4_RS23540	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K10K4_RS23565	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K10K4_RS23595	COG3842	ATPase activity
K10K4_RS23615	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K10K4_RS23645	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K10K4_RS23650	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K10K4_RS23685	COG0583	DNA-binding transcription factor activity
K10K4_RS23695	COG4948	Mandelate Racemase Muconate Lactonizing
K10K4_RS23730	COG1342	Belongs to the UPF0251 family
K10K4_RS23735	COG4176	ABC-type proline glycine betaine transport system permease component
K10K4_RS23740	COG4175	Glycine betaine
K10K4_RS23740	COG3448	diguanylate cyclase activity
K10K4_RS23745	COG3015	lipoprotein NlpE involved in copper resistance
K10K4_RS23750	COG3713	MltA-interacting MipA family protein
K10K4_RS23765	COG0583	DNA-binding transcription factor activity
K10K4_RS23790	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
K10K4_RS23800	COG1335	isochorismatase
K10K4_RS23815	COG1349	DNA-binding transcription factor activity
K10K4_RS23825	COG2070	2-Nitropropane dioxygenase
K10K4_RS23830	COG0531	amino acid
K10K4_RS23835	COG4302	ethanolamine ammonia-lyase activity
K10K4_RS23840	COG4303	Ethanolamine ammonia lyase large subunit
K10K4_RS23850	COG1309	transcriptional regulator
K10K4_RS23870	COG1280	lysine exporter protein (LysE YggA)
K10K4_RS23880	COG0459	protein refolding
K10K4_RS23885	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
K10K4_RS23895	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K10K4_RS23910	COG1304	FMN binding
K10K4_RS23935	COG4786	Flagellar basal body rod
K10K4_RS23935	COG1256	bacterial-type flagellum assembly
K10K4_RS23945	COG1706	bacterial-type flagellum-dependent cell motility
K10K4_RS23950	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
K10K4_RS23955	COG4786	Flagellar basal body rod
K10K4_RS23960	COG4787	bacterial-type flagellum-dependent cell motility
K10K4_RS23975	COG1558	bacterial-type flagellum-dependent cell motility
K10K4_RS23980	COG1815	bacterial-type flagellum-dependent cell motility
K10K4_RS24000	COG0741	lytic transglycosylase activity
K10K4_RS24005	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K10K4_RS24025	COG1760	l-serine dehydratase
K10K4_RS24040	COG0583	DNA-binding transcription factor activity
K10K4_RS24050	COG2866	Carboxypeptidase
K10K4_RS24055	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K10K4_RS24065	COG2990	Protein conserved in bacteria
K10K4_RS24090	COG3842	ATPase activity
K10K4_RS24100	COG1840	ABC-type Fe3 transport system, periplasmic component
K10K4_RS24110	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K10K4_RS24120	COG1609	Transcriptional regulator
K10K4_RS24150	COG3240	lipase activity
K10K4_RS24155	COG1309	transcriptional regulator
K10K4_RS24170	COG1136	(ABC) transporter
K10K4_RS24170	COG0577	efflux transmembrane transporter activity
K10K4_RS24175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K10K4_RS24180	COG2067	long-chain fatty acid transport protein
K10K4_RS24190	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
K10K4_RS24205	COG1011	Hydrolase
K10K4_RS24245	COG0110	maltose O-acetyltransferase activity
K10K4_RS24250	COG1765	OsmC-like protein
K10K4_RS24255	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K10K4_RS24255	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K10K4_RS24270	COG3046	protein related to deoxyribodipyrimidine photolyase
K10K4_RS24275	COG0415	Belongs to the DNA photolyase family
K10K4_RS24280	COG3706	GGDEF domain
K10K4_RS24295	COG3706	GGDEF domain
K10K4_RS24310	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K10K4_RS24330	COG3033	Beta-eliminating lyase
K10K4_RS24340	COG1271	oxidase subunit
K10K4_RS24345	COG1294	oxidase, subunit
K10K4_RS24365	COG3179	chitinase
K10K4_RS24370	COG0579	oxidoreductase
K10K4_RS24390	COG3706	GGDEF domain
K10K4_RS24425	COG0583	DNA-binding transcription factor activity
K10K4_RS24450	COG0189	ligase activity
K10K4_RS24455	COG0189	ligase activity
K10K4_RS24455	COG4067	protein conserved in archaea
K10K4_RS24465	COG1166	arginine decarboxylase activity
K10K4_RS24470	COG0010	Belongs to the arginase family
K10K4_RS24475	COG2814	Major facilitator Superfamily
K10K4_RS24480	COG1770	oligopeptidase
K10K4_RS24495	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K10K4_RS24500	COG1121	(ABC) transporter
K10K4_RS24505	COG0803	Belongs to the bacterial solute-binding protein 9 family
K10K4_RS24545	COG0848	biopolymer transport protein
K10K4_RS24550	COG0811	peptide transport
K10K4_RS24555	COG0811	peptide transport
K10K4_RS24575	COG0745	RESPONSE REGULATOR receiver
K10K4_RS24580	COG0584	glycerophosphoryl diester phosphodiesterase
K10K4_RS24590	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K10K4_RS24655	COG0312	modulator of DNA gyrase
K10K4_RS24660	COG0312	modulator of DNA gyrase
K10K4_RS24665	COG0351	phosphomethylpyrimidine kinase
K10K4_RS24670	COG1116	anion transmembrane transporter activity
K10K4_RS24675	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K10K4_RS24680	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K10K4_RS24685	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
K10K4_RS24705	COG0243	molybdopterin cofactor binding
K10K4_RS24710	COG3005	denitrification pathway
K10K4_RS24715	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K10K4_RS24720	COG1028	Short-chain dehydrogenase reductase Sdr
K10K4_RS24735	COG0456	acetyltransferase
K10K4_RS24755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K10K4_RS24760	COG1929	Belongs to the glycerate kinase type-1 family
K10K4_RS24765	COG2610	gluconate transmembrane transporter activity
K10K4_RS24770	COG3835	regulator
K10K4_RS24830	COG3047	cAMP biosynthetic process
K10K4_RS24835	COG1357	PFAM Pentapeptide repeats (8 copies)
K10K4_RS24865	COG2375	cellular response to nickel ion
K10K4_RS24870	COG0583	DNA-binding transcription factor activity
K10K4_RS24875	COG2162	N-hydroxyarylamine O-acetyltransferase activity
K10K4_RS24880	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
K10K4_RS24895	COG2199	diguanylate cyclase activity
K10K4_RS24905	COG0561	phosphatase activity
K10K4_RS24910	COG0583	DNA-binding transcription factor activity
K10K4_RS24925	COG0564	pseudouridine synthase activity
K10K4_RS24930	COG0534	Mate efflux family protein
K10K4_RS24945	COG3123	guanosine phosphorylase activity
K10K4_RS24960	COG0596	Alpha beta hydrolase
K10K4_RS24985	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K10K4_RS24995	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K10K4_RS25000	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K10K4_RS25000	COG2169	Transcriptional regulator
K10K4_RS25010	COG2259	Doxx family
K10K4_RS25015	COG1741	Belongs to the pirin family
K10K4_RS25035	COG0363	glucosamine-6-phosphate deaminase activity
K10K4_RS25045	COG0786	glutamate:sodium symporter activity
K10K4_RS25050	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K10K4_RS25055	COG1131	(ABC) transporter
K10K4_RS25065	COG0786	glutamate:sodium symporter activity
K10K4_RS25090	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K10K4_RS25100	COG3279	Response regulator of the LytR AlgR family
K10K4_RS25105	COG3275	phosphorelay sensor kinase activity
K10K4_RS25135	COG0772	Belongs to the SEDS family
K10K4_RS25160	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K10K4_RS25160	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
K10K4_RS25170	COG0444	Belongs to the ABC transporter superfamily
K10K4_RS25175	COG4608	Belongs to the ABC transporter superfamily