locus-tag	class	description
N646_RS00005	COG1169	isochorismate synthase
N646_RS00020	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
N646_RS00040	COG2855	membrane
N646_RS00045	COG0477	Major facilitator Superfamily
N646_RS00070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N646_RS00075	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
N646_RS00090	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
N646_RS00095	COG1522	sequence-specific DNA binding
N646_RS00105	COG1946	Acyl-CoA thioesterase
N646_RS00110	COG3126	Type III secretion system lipoprotein chaperone (YscW)
N646_RS00130	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
N646_RS00135	COG0516	GMP reductase activity
N646_RS00135	COG0517	IMP dehydrogenase activity
N646_RS00160	COG0537	adenosine 5'-monophosphoramidase activity
N646_RS00185	COG3150	esterase
N646_RS00190	COG1252	NADH dehydrogenase
N646_RS00205	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
N646_RS00215	COG4591	ABC-type transport system involved in lipoprotein release permease component
N646_RS00220	COG1136	(ABC) transporter
N646_RS00225	COG4591	ABC-type transport system involved in lipoprotein release permease component
N646_RS00235	COG0658	competence protein
N646_RS00235	COG2333	competence protein COMEC
N646_RS00240	COG1132	(ABC) transporter
N646_RS00260	COG2719	SpoVR family
N646_RS00265	COG2718	Belongs to the UPF0229 family
N646_RS00270	COG2766	serine protein kinase
N646_RS00275	COG3013	Belongs to the UPF0304 family
N646_RS00285	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
N646_RS00295	COG1882	Formate acetyltransferase
N646_RS00335	COG0708	Exodeoxyribonuclease III
N646_RS00345	COG3923	Primosomal replication protein n
N646_RS00350	COG0730	response to heat
N646_RS00355	COG1199	ATP-dependent helicase activity
N646_RS00360	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
N646_RS00365	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
N646_RS00370	COG1187	pseudouridine synthase activity
N646_RS00380	COG1278	Cold shock
N646_RS00385	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
N646_RS00390	COG0542	response to heat
N646_RS00395	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
N646_RS00400	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
N646_RS00405	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
N646_RS00425	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
N646_RS00430	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
N646_RS00435	COG0297	glycogen (starch) synthase activity
N646_RS00455	COG3070	regulator of competence-specific genes
N646_RS00460	COG1609	Transcriptional regulator
N646_RS00465	COG3381	protein complex oligomerization
N646_RS00470	COG0745	RESPONSE REGULATOR receiver
N646_RS00475	COG1434	Gram-negative-bacterium-type cell wall biogenesis
N646_RS00480	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
N646_RS00490	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
N646_RS00495	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
N646_RS00510	COG4067	protein conserved in archaea
N646_RS00510	COG0189	ligase activity
N646_RS00515	COG0500	methyltransferase
N646_RS00525	COG1801	Protein of unknown function DUF72
N646_RS00535	COG0217	transcriptional regulatory protein
N646_RS00540	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
N646_RS00545	COG0632	four-way junction helicase activity
N646_RS00550	COG2255	four-way junction helicase activity
N646_RS00555	COG1271	oxidase subunit
N646_RS00560	COG1294	oxidase, subunit
N646_RS00575	COG0824	Thioesterase
N646_RS00580	COG0811	peptide transport
N646_RS00595	COG0823	Involved in the tonB-independent uptake of proteins
N646_RS00600	COG2885	chlorophyll binding
N646_RS00605	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
N646_RS00610	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
N646_RS00620	COG3766	membrane
N646_RS00630	COG0754	glutathionylspermidine amidase activity
N646_RS00640	COG0784	Response regulator, receiver
N646_RS00640	COG5002	protein histidine kinase activity
N646_RS00670	COG1294	oxidase, subunit
N646_RS00675	COG1271	oxidase subunit
N646_RS00695	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N646_RS00700	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
N646_RS00725	COG3568	Endonuclease Exonuclease Phosphatase
N646_RS00750	COG0583	DNA-binding transcription factor activity
N646_RS00760	COG0686	Belongs to the AlaDH PNT family
N646_RS00770	COG1674	ftsk spoiiie
N646_RS00780	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
N646_RS00790	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
N646_RS00815	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
N646_RS00830	COG0300	oxidoreductase activity
N646_RS00845	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
N646_RS00855	COG2268	Band 7 protein
N646_RS00865	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
N646_RS00870	COG2915	High frequency lysogenization protein hflD homolog
N646_RS00885	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N646_RS00895	COG1757	Na H antiporter
N646_RS00910	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
N646_RS00920	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
N646_RS00920	COG0131	Imidazoleglycerol-phosphate dehydratase
N646_RS00925	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
N646_RS00930	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
N646_RS00940	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
N646_RS00940	COG0140	phosphoribosyl-ATP diphosphatase activity
N646_RS00945	COG3012	SEC-C Motif Domain Protein
N646_RS00950	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
N646_RS00955	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
N646_RS00960	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
N646_RS00965	COG0215	cysteine-tRNA ligase activity
N646_RS00970	COG1435	thymidine kinase activity
N646_RS01000	COG2116	formate transmembrane transporter activity
N646_RS01005	COG0390	transport system, permease component
N646_RS01015	COG3005	denitrification pathway
N646_RS01020	COG0243	molybdopterin cofactor binding
N646_RS01035	COG1227	inorganic diphosphatase activity
N646_RS01045	COG4172	Belongs to the ABC transporter superfamily
N646_RS01055	COG4171	peptide transport system, permease
N646_RS01070	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
N646_RS01075	COG1842	Phage shock protein A
N646_RS01085	COG1983	PspC domain protein
N646_RS01105	COG2818	Glycosylase
N646_RS01110	COG5380	lipid catabolic process
N646_RS01115	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
N646_RS01120	COG0626	cystathionine gamma-synthase activity
N646_RS01130	COG0733	neurotransmitter:sodium symporter activity
N646_RS01135	COG0564	pseudouridine synthase activity
N646_RS01140	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
N646_RS01140	COG0116	Belongs to the methyltransferase superfamily
N646_RS01145	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
N646_RS01150	COG1151	hydroxylamine reductase activity
N646_RS01155	COG3604	Transcriptional regulator
N646_RS01165	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
N646_RS01170	COG4136	ATPase activity
N646_RS01175	COG4135	transport system, permease component
N646_RS01180	COG4134	Bacterial extracellular solute-binding protein
N646_RS01190	COG3313	Fe-S protein
N646_RS01210	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
N646_RS01235	COG1187	pseudouridine synthase activity
N646_RS01245	COG2814	Major facilitator Superfamily
N646_RS01255	COG0702	epimerase
N646_RS01260	COG0534	Mate efflux family protein
N646_RS01280	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
N646_RS01290	COG1960	acyl-CoA dehydrogenase activity
N646_RS01295	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
N646_RS01300	COG2985	domain, Protein
N646_RS01300	COG3273	potassium ion transport
N646_RS01305	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
N646_RS01315	COG1737	Transcriptional regulator
N646_RS01320	COG0076	glutamate decarboxylase activity
N646_RS01330	COG2431	L-lysine efflux transmembrane transporter activity
N646_RS01340	COG3070	regulator of competence-specific genes
N646_RS01355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N646_RS01355	COG4191	Histidine kinase
N646_RS01365	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
N646_RS01375	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
N646_RS01380	COG4988	ABC transporter
N646_RS01385	COG0492	ferredoxin-NADP+ reductase activity
N646_RS01410	COG0471	metal ion transport
N646_RS01415	COG2949	membrane
N646_RS01420	COG0281	malic enzyme
N646_RS01425	COG1643	Atp-dependent helicase
N646_RS01440	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
N646_RS01475	COG0247	lactate metabolic process
N646_RS01475	COG0277	FAD linked oxidase domain protein
N646_RS01490	COG2986	histidine ammonia-lyase
N646_RS01495	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
N646_RS01500	COG0010	Belongs to the arginase family
N646_RS01505	COG1228	amidohydrolase
N646_RS01510	COG2188	Transcriptional regulator
N646_RS01525	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
N646_RS01535	COG0291	Belongs to the bacterial ribosomal protein bL35 family
N646_RS01545	COG0393	Putative heavy-metal-binding
N646_RS01580	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
N646_RS01585	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N646_RS01585	COG0072	phenylalanine-tRNA ligase activity
N646_RS01595	COG0776	regulation of translation
N646_RS01605	COG0500	methyltransferase
N646_RS01610	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
N646_RS01615	COG0295	cytidine deaminase activity
N646_RS01620	COG1346	cytolysis
N646_RS01625	COG1380	Effector of murein hydrolase LrgA
N646_RS01630	COG2925	Exonuclease
N646_RS01635	COG1823	symporter activity
N646_RS01640	COG0702	epimerase
N646_RS01650	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
N646_RS01670	COG2988	succinylglutamate desuccinylase activity
N646_RS01675	COG4139	cobalamin transport
N646_RS01680	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
N646_RS01700	COG0583	DNA-binding transcription factor activity
N646_RS01710	COG1451	nucleotide metabolic process
N646_RS01715	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
N646_RS01745	COG3938	Belongs to the proline racemase family
N646_RS01760	COG2423	ornithine cyclodeaminase activity
N646_RS01765	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N646_RS01770	COG3842	ATPase activity
N646_RS01775	COG1176	ABC-type spermidine putrescine transport system, permease component I
N646_RS01780	COG1177	transmembrane transport
N646_RS01790	COG3291	Pkd domain containing protein
N646_RS01810	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N646_RS01815	COG0601	transmembrane transport
N646_RS01825	COG2195	Cleaves the N-terminal amino acid of tripeptides
N646_RS01835	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
N646_RS01845	COG0625	glutathione transferase activity
N646_RS01895	COG3755	Protein conserved in bacteria
N646_RS01920	COG1742	UPF0060 membrane protein
N646_RS01935	COG1757	Na H antiporter
N646_RS01940	COG0174	glutamine synthetase
N646_RS01945	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
N646_RS01950	COG1396	sequence-specific DNA binding
N646_RS01950	COG1917	Cupin 2, conserved barrel domain protein
N646_RS01955	COG1012	belongs to the aldehyde dehydrogenase family
N646_RS01960	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N646_RS01970	COG2957	Belongs to the agmatine deiminase family
N646_RS01975	COG1012	belongs to the aldehyde dehydrogenase family
N646_RS01980	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
N646_RS01985	COG2200	EAL domain
N646_RS01995	COG1846	Transcriptional regulator
N646_RS02000	COG2315	Protein conserved in bacteria
N646_RS02040	COG3063	Type IV pilus biogenesis stability protein PilW
N646_RS02045	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
N646_RS02060	COG1560	Kdo2-lipid A biosynthetic process
N646_RS02065	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
N646_RS02070	COG1280	lysine exporter protein (LysE YggA)
N646_RS02080	COG1115	amino acid carrier protein
N646_RS02105	COG1368	sulfuric ester hydrolase activity
N646_RS02110	COG2113	Glycine betaine
N646_RS02115	COG4176	ABC-type proline glycine betaine transport system permease component
N646_RS02120	COG4175	Glycine betaine
N646_RS02135	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
N646_RS02140	COG0456	acetyltransferase
N646_RS02145	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
N646_RS02150	COG0662	Cupin 2, conserved barrel domain protein
N646_RS02155	COG0527	aspartate kinase activity
N646_RS02165	COG3119	arylsulfatase activity
N646_RS02180	COG0641	radical SAM
N646_RS02195	COG3119	arylsulfatase activity
N646_RS02225	COG1538	Outer membrane efflux protein
N646_RS02240	COG1349	DNA-binding transcription factor activity
N646_RS02245	COG0673	inositol 2-dehydrogenase activity
N646_RS02250	COG4702	Belongs to the UPF0303 family
N646_RS02275	COG0471	metal ion transport
N646_RS02290	COG5001	Diguanylate cyclase
N646_RS02290	COG3300	MHYT domain
N646_RS02305	COG1328	CTP reductase activity
N646_RS02310	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
N646_RS02320	COG0861	Integral membrane protein TerC family
N646_RS02330	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
N646_RS02340	COG0814	amino acid
N646_RS02355	COG1120	ATPase activity
N646_RS02360	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
N646_RS02370	COG4774	siderophore transport
N646_RS02380	COG1132	(ABC) transporter
N646_RS02385	COG1132	(ABC) transporter
N646_RS02400	COG0583	DNA-binding transcription factor activity
N646_RS02425	COG0443	Heat shock 70 kDa protein
N646_RS02430	COG0443	Heat shock 70 kDa protein
N646_RS02475	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
N646_RS02480	COG1643	Atp-dependent helicase
N646_RS02495	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
N646_RS02505	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
N646_RS02510	COG1215	transferase activity, transferring glycosyl groups
N646_RS02515	COG0438	transferase activity, transferring glycosyl groups
N646_RS02545	COG0438	transferase activity, transferring glycosyl groups
N646_RS02550	COG0297	glycogen (starch) synthase activity
N646_RS02555	COG2204	response regulator
N646_RS02585	COG1793	dna ligase
N646_RS02595	COG0534	Mate efflux family protein
N646_RS02600	COG0307	riboflavin synthase, alpha
N646_RS02610	COG3001	Fructosamine kinase
N646_RS02620	COG3706	GGDEF domain
N646_RS02630	COG0791	NLP P60 protein
N646_RS02660	COG3148	PFAM DTW domain containing protein
N646_RS02665	COG1940	carbohydrate kinase activity
N646_RS02675	COG0303	'Molybdopterin
N646_RS02680	COG0746	molybdenum cofactor guanylyltransferase activity
N646_RS02685	COG3842	ATPase activity
N646_RS02700	COG2204	response regulator
N646_RS02705	COG3852	Histidine kinase
N646_RS02710	COG0488	(ABC) transporter
N646_RS02720	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
N646_RS02740	COG3381	protein complex oligomerization
N646_RS02750	COG3383	formate dehydrogenase (NAD+) activity
N646_RS02750	COG0243	molybdopterin cofactor binding
N646_RS02755	COG0437	4 iron, 4 sulfur cluster binding
N646_RS02780	COG0004	ammonium transporteR
N646_RS02785	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
N646_RS02790	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
N646_RS02800	COG1177	transmembrane transport
N646_RS02810	COG3842	ATPase activity
N646_RS02840	COG0589	response to stress
N646_RS02845	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
N646_RS02860	COG2217	Heavy metal translocating P-type atpase
N646_RS02870	COG2010	Cytochrome c
N646_RS02885	COG3278	Belongs to the heme-copper respiratory oxidase family
N646_RS02900	COG0784	Response regulator, receiver
N646_RS02900	COG2205	protein histidine kinase activity
N646_RS02950	COG4128	Pfam Zonular occludens toxin
N646_RS02985	COG3120	sequence-specific DNA binding
N646_RS02990	COG1067	ATP-dependent peptidase activity
N646_RS02995	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
N646_RS03010	COG0488	(ABC) transporter
N646_RS03020	COG0116	Belongs to the methyltransferase superfamily
N646_RS03020	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
N646_RS03030	COG0167	dihydroorotate dehydrogenase activity
N646_RS03035	COG2902	Dehydrogenase
N646_RS03040	COG0308	aminopeptidase N
N646_RS03055	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
N646_RS03060	COG1956	GAF domain-containing protein
N646_RS03065	COG1132	(ABC) transporter
N646_RS03070	COG2995	paraquat-inducible protein a
N646_RS03075	COG3008	intermembrane lipid transfer
N646_RS03100	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
N646_RS03105	COG1666	GTP binding
N646_RS03115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N646_RS03120	COG4597	amino acid ABC transporter
N646_RS03125	COG0765	amino acid transport
N646_RS03130	COG1126	abc transporter atp-binding protein
N646_RS03135	COG0670	Belongs to the BI1 family
N646_RS03145	COG2920	part of a sulfur-relay system
N646_RS03150	COG1254	Belongs to the acylphosphatase family
N646_RS03155	COG0840	transmembrane signaling receptor activity
N646_RS03205	COG2885	chlorophyll binding
N646_RS03230	COG2203	Gaf domain
N646_RS03230	COG2199	diguanylate cyclase activity
N646_RS03235	COG1414	Transcriptional regulator
N646_RS03245	COG0656	L-ascorbic acid biosynthetic process
N646_RS03250	COG0583	DNA-binding transcription factor activity
N646_RS03260	COG0583	DNA-binding transcription factor activity
N646_RS03265	COG2814	Major facilitator Superfamily
N646_RS03285	COG1335	isochorismatase
N646_RS03290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N646_RS03305	COG1410	methionine synthase
N646_RS03305	COG0646	methionine synthase
N646_RS03310	COG1126	abc transporter atp-binding protein
N646_RS03315	COG0765	amino acid transport
N646_RS03320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N646_RS03335	COG0583	DNA-binding transcription factor activity
N646_RS03350	COG0583	DNA-binding transcription factor activity
N646_RS03360	COG0583	DNA-binding transcription factor activity
N646_RS03375	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
N646_RS03380	COG0602	queuosine metabolic process
N646_RS03385	COG0561	phosphatase activity
N646_RS03410	COG2828	Protein conserved in bacteria
N646_RS03420	COG0372	Belongs to the citrate synthase family
N646_RS03425	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
N646_RS03460	COG0730	response to heat
N646_RS03465	COG2358	TRAP transporter, solute receptor (TAXI family
N646_RS03490	COG0457	Tetratricopeptide repeat
N646_RS03560	COG4790	Type iii secretion
N646_RS03565	COG4794	Type iii secretion
N646_RS03570	COG4791	protein targeting
N646_RS03575	COG4792	protein secretion
N646_RS03580	COG2207	Transcriptional regulator
N646_RS03610	COG3177	Filamentation induced by cAMP protein fic
N646_RS03630	COG4669	(LipO)protein
N646_RS03700	COG1012	belongs to the aldehyde dehydrogenase family
N646_RS03705	COG3284	Transcriptional regulator
N646_RS03715	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
N646_RS03720	COG0363	glucosamine-6-phosphate deaminase activity
N646_RS03725	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
N646_RS03730	COG2207	Transcriptional regulator
N646_RS03740	COG4565	transcriptional regulatory protein
N646_RS03745	COG3290	protein histidine kinase activity
N646_RS03760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N646_RS03775	COG0583	DNA-binding transcription factor activity
N646_RS03790	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
N646_RS03800	COG2985	domain, Protein
N646_RS03825	COG2272	Belongs to the type-B carboxylesterase lipase family
N646_RS03830	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
N646_RS03835	COG0729	surface antigen
N646_RS03845	COG1280	lysine exporter protein (LysE YggA)
N646_RS03850	COG1280	lysine exporter protein (LysE YggA)
N646_RS03855	COG5507	3-demethylubiquinone-9 3-methyltransferase
N646_RS03875	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
N646_RS03880	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
N646_RS03885	COG0110	maltose O-acetyltransferase activity
N646_RS03940	COG2211	Major facilitator Superfamily
N646_RS03955	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
N646_RS03960	COG1028	Short-chain dehydrogenase reductase Sdr
N646_RS03965	COG1169	isochorismate synthase
N646_RS03970	COG1021	2,3-dihydroxybenzoate-AMP ligase
N646_RS03975	COG3433	isochorismatase activity
N646_RS03975	COG1535	isochorismatase
N646_RS03980	COG4592	Periplasmic binding protein
N646_RS03990	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N646_RS03995	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N646_RS04000	COG1120	ATPase activity
N646_RS04015	COG2382	esterase
N646_RS04020	COG4774	siderophore transport
N646_RS04020	COG1629	transport
N646_RS04040	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
N646_RS04105	COG0456	acetyltransferase
N646_RS04120	COG0456	acetyltransferase
N646_RS04250	COG2026	Addiction module toxin, RelE StbE family
N646_RS04255	COG2801	Transposase and inactivated derivatives
N646_RS04270	COG2801	Transposase and inactivated derivatives
N646_RS04280	COG1357	PFAM Pentapeptide repeats (8 copies)
N646_RS04285	COG2801	Transposase and inactivated derivatives
N646_RS04410	COG0625	glutathione transferase activity
N646_RS04425	COG2026	Addiction module toxin, RelE StbE family
N646_RS04445	COG1335	isochorismatase
N646_RS04485	COG2026	Addiction module toxin, RelE StbE family
N646_RS04490	COG2801	Transposase and inactivated derivatives
N646_RS04530	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
N646_RS04540	COG3768	UPF0283 membrane protein
N646_RS04545	COG3106	COG3106 Predicted ATPase
N646_RS04560	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
N646_RS04565	COG2205	protein histidine kinase activity
N646_RS04565	COG0784	Response regulator, receiver
N646_RS04575	COG0494	nUDIX hydrolase
N646_RS04580	COG0814	amino acid
N646_RS04585	COG1760	l-serine dehydratase
N646_RS04590	COG2200	EAL domain
N646_RS04600	COG0720	synthase
N646_RS04610	COG5002	protein histidine kinase activity
N646_RS04610	COG2205	protein histidine kinase activity
N646_RS04610	COG0784	Response regulator, receiver
N646_RS04615	COG5001	Diguanylate cyclase
N646_RS04615	COG3300	MHYT domain
N646_RS04620	COG0840	transmembrane signaling receptor activity
N646_RS04625	COG0017	Asparaginyl-tRNA synthetase
N646_RS04635	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N646_RS04650	COG1448	Aminotransferase
N646_RS04675	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
N646_RS04705	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
N646_RS04720	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N646_RS04725	COG3108	Peptidase M15
N646_RS04730	COG2989	Protein conserved in bacteria
N646_RS04755	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
N646_RS04765	COG3088	subunit of a heme lyase
N646_RS04765	COG4235	cytochrome complex assembly
N646_RS04775	COG1138	Cytochrome C-type biogenesis protein
N646_RS04780	COG3301	Polysulphide reductase, NrfD
N646_RS04785	COG0437	4 iron, 4 sulfur cluster binding
N646_RS04795	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
N646_RS04815	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
N646_RS04820	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N646_RS04850	COG0019	diaminopimelate decarboxylase activity
N646_RS04890	COG0322	excinuclease ABC activity
N646_RS04895	COG2197	response regulator
N646_RS04900	COG0417	DNA replication proofreading
N646_RS04920	COG1187	pseudouridine synthase activity
N646_RS04930	COG0009	L-threonylcarbamoyladenylate synthase
N646_RS04935	COG0613	PHP domain protein
N646_RS04945	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
N646_RS04950	COG0512	Glutamine amidotransferase of anthranilate synthase
N646_RS04960	COG0134	indole-3-glycerol-phosphate synthase activity
N646_RS04960	COG0135	phosphoribosylanthranilate isomerase activity
N646_RS04970	COG0159	tryptophan synthase activity
N646_RS04975	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
N646_RS04980	COG0318	PFAM AMP-dependent synthetase and ligase
N646_RS04990	COG1301	dicarboxylic acid transport
N646_RS05010	COG2917	probably involved in intracellular septation
N646_RS05020	COG2350	Protein conserved in bacteria
N646_RS05030	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
N646_RS05050	COG5001	Diguanylate cyclase
N646_RS05055	COG1032	radical SAM domain protein
N646_RS05075	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
N646_RS05080	COG0463	Glycosyl transferase, family 2
N646_RS05085	COG0745	RESPONSE REGULATOR receiver
N646_RS05090	COG5002	protein histidine kinase activity
N646_RS05090	COG3850	Histidine kinase
N646_RS05140	COG1136	(ABC) transporter
N646_RS05140	COG0577	efflux transmembrane transporter activity
N646_RS05145	COG0577	efflux transmembrane transporter activity
N646_RS05145	COG1136	(ABC) transporter
N646_RS05150	COG0577	efflux transmembrane transporter activity
N646_RS05150	COG1136	(ABC) transporter
N646_RS05160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N646_RS05180	COG3118	belongs to the thioredoxin family
N646_RS05185	COG4232	protein-disulfide reductase activity
N646_RS05220	COG2863	cytochrome
N646_RS05225	COG3258	Cytochrome c
N646_RS05230	COG2995	paraquat-inducible protein a
N646_RS05235	COG3008	intermembrane lipid transfer
N646_RS05235	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
N646_RS05255	COG4166	transmembrane transport
N646_RS05265	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
N646_RS05270	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
N646_RS05280	COG0539	negative regulation of cytoplasmic translation
N646_RS05285	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
N646_RS05290	COG0616	signal peptide processing
N646_RS05295	COG1028	Short-chain dehydrogenase reductase Sdr
N646_RS05310	COG0587	DNA-directed DNA polymerase activity
N646_RS05315	COG0835	chemotaxis
N646_RS05315	COG0784	Response regulator, receiver
N646_RS05320	COG1940	carbohydrate kinase activity
N646_RS05325	COG0469	pyruvate kinase activity
N646_RS05330	COG4667	esterase of the alpha-beta hydrolase superfamily
N646_RS05345	COG0733	neurotransmitter:sodium symporter activity
N646_RS05355	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N646_RS05355	COG1263	PTS System
N646_RS05360	COG0084	hydrolase, TatD family'
N646_RS05365	COG0470	DNA polymerase III
N646_RS05370	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
N646_RS05375	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
N646_RS05405	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
N646_RS05410	COG0416	fatty acid biosynthetic process
N646_RS05420	COG1399	metal-binding, possibly nucleic acid-binding protein
N646_RS05425	COG0424	maF-like protein
N646_RS05430	COG0564	pseudouridine synthase activity
N646_RS05435	COG1530	ribonuclease E activity
N646_RS05440	COG0659	secondary active sulfate transmembrane transporter activity
N646_RS05445	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
N646_RS05450	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
N646_RS05460	COG0572	uridine kinase
N646_RS05470	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N646_RS05470	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N646_RS05480	COG2186	Transcriptional regulator
N646_RS05485	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
N646_RS05490	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
N646_RS05495	COG0653	protein targeting
N646_RS05500	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
N646_RS05505	COG3706	GGDEF domain
N646_RS05510	COG0366	Alpha amylase catalytic
N646_RS05515	COG1122	ATPase activity
N646_RS05520	COG4120	Belongs to the binding-protein-dependent transport system permease family
N646_RS05530	COG3092	negative regulation of chromosome organization
N646_RS05535	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
N646_RS05540	COG0857	belongs to the CobB CobQ family
N646_RS05540	COG0280	phosphate acetyltransferase
N646_RS05550	COG0435	Glutathione S-transferase
N646_RS05560	COG0444	Belongs to the ABC transporter superfamily
N646_RS05565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N646_RS05570	COG0601	transmembrane transport
N646_RS05580	COG0314	molybdopterin synthase activity
N646_RS05585	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
N646_RS05590	COG0315	cyclic pyranopterin monophosphate synthase activity
N646_RS05595	COG0521	Mo-molybdopterin cofactor biosynthetic process
N646_RS05600	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
N646_RS05605	COG0391	Required for morphogenesis under gluconeogenic growth conditions
N646_RS05610	COG2198	Histidine kinase
N646_RS05615	COG2204	response regulator
N646_RS05620	COG0556	nucleotide-excision repair
N646_RS05630	COG1882	Formate acetyltransferase
N646_RS05635	COG4657	Part of a membrane complex involved in electron transport
N646_RS05640	COG2878	Part of a membrane complex involved in electron transport
N646_RS05645	COG4656	Part of a membrane complex involved in electron transport
N646_RS05650	COG4658	electron transport chain
N646_RS05655	COG4659	FMN binding
N646_RS05660	COG4660	Part of a membrane complex involved in electron transport
N646_RS05665	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
N646_RS05670	COG0346	lactoylglutathione lyase activity
N646_RS05685	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
N646_RS05690	COG2056	Na+-H+ antiporter family
N646_RS05820	COG4695	Portal protein
N646_RS05905	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
N646_RS05920	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
N646_RS05940	COG1454	alcohol dehydrogenase
N646_RS05940	COG1012	belongs to the aldehyde dehydrogenase family
N646_RS05945	COG2095	MarC family integral membrane protein
N646_RS05950	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
N646_RS05955	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
N646_RS05960	COG1757	Na H antiporter
N646_RS05975	COG3081	Nucleoid-associated protein
N646_RS05980	COG3082	Protein of unknown function (DUF1414)
N646_RS05995	COG0123	including yeast histone deacetylase and acetoin utilization protein
N646_RS06010	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
N646_RS06015	COG0778	Nitroreductase
N646_RS06025	COG0446	pyridine nucleotide-disulphide oxidoreductase
N646_RS06025	COG1902	pentaerythritol trinitrate reductase activity
N646_RS06030	COG0616	signal peptide processing
N646_RS06035	COG0252	asparaginase activity
N646_RS06040	COG3139	Protein of unknown function (DUF1315)
N646_RS06050	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N646_RS06055	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
N646_RS06070	COG2226	methyltransferase
N646_RS06085	COG1785	Belongs to the alkaline phosphatase family
N646_RS06095	COG0346	lactoylglutathione lyase activity
N646_RS06100	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
N646_RS06105	COG0668	transmembrane transport
N646_RS06110	COG2983	Belongs to the UPF0260 family
N646_RS06115	COG2261	transglycosylase associated protein
N646_RS06125	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
N646_RS06130	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
N646_RS06145	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
N646_RS06150	COG2832	Protein of unknown function (DUF454)
N646_RS06160	COG0745	RESPONSE REGULATOR receiver
N646_RS06165	COG0583	DNA-binding transcription factor activity
N646_RS06170	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
N646_RS06175	COG1286	toxin biosynthetic process
N646_RS06180	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
N646_RS06185	COG0285	dihydrofolate synthase activity
N646_RS06190	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
N646_RS06195	COG0101	tRNA pseudouridine synthase activity
N646_RS06205	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
N646_RS06210	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
N646_RS06220	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
N646_RS06225	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
N646_RS06225	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N646_RS06230	COG0431	NADPH-dependent FMN reductase
N646_RS06240	COG3101	peptidyl-lysine hydroxylation
N646_RS06245	COG2860	membrane
N646_RS06250	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
N646_RS06255	COG2890	protein-(glutamine-N5) methyltransferase activity
N646_RS06265	COG2062	phosphohistidine phosphatase, SixA
N646_RS06280	COG1024	Enoyl-CoA hydratase
N646_RS06280	COG1250	3-hydroxyacyl-CoA dehydrogenase
N646_RS06285	COG0183	Belongs to the thiolase family
N646_RS06310	COG2067	long-chain fatty acid transport protein
N646_RS06320	COG4235	cytochrome complex assembly
N646_RS06320	COG3088	subunit of a heme lyase
N646_RS06330	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
N646_RS06335	COG1138	Cytochrome C-type biogenesis protein
N646_RS06340	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
N646_RS06345	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
N646_RS06350	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
N646_RS06355	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
N646_RS06360	COG4133	protoheme IX ABC transporter activity
N646_RS06370	COG0835	chemotaxis
N646_RS06380	COG1192	Involved in chromosome partitioning
N646_RS06385	COG2201	protein-glutamate methylesterase activity
N646_RS06390	COG0643	Histidine kinase
N646_RS06390	COG0784	Response regulator, receiver
N646_RS06390	COG2198	Histidine kinase
N646_RS06395	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
N646_RS06430	COG1684	flagellar biosynthetic protein fliR
N646_RS06435	COG1987	bacterial-type flagellum assembly
N646_RS06490	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
N646_RS06500	COG1677	Flagellar hook-basal body complex protein FliE
N646_RS06520	COG1516	flagellar protein fliS
N646_RS06530	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
N646_RS06535	COG1334	flagellar protein FlaG
N646_RS06540	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
N646_RS06545	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
N646_RS06550	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
N646_RS06555	COG2837	iron assimilation
N646_RS06580	COG1393	Belongs to the ArsC family
N646_RS06585	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N646_RS06600	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
N646_RS06605	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N646_RS06615	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
N646_RS06630	COG4783	chaperone-mediated protein folding
N646_RS06635	COG1393	Belongs to the ArsC family
N646_RS06655	COG2233	PERMEase
N646_RS06660	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
N646_RS06665	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
N646_RS06670	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
N646_RS06675	COG0121	glutamine amidotransferase
N646_RS06680	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
N646_RS06685	COG1960	acyl-CoA dehydrogenase activity
N646_RS06720	COG0328	RNA-DNA hybrid ribonuclease activity
N646_RS06725	COG2226	methyltransferase
N646_RS06730	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N646_RS06735	COG1388	LysM domain
N646_RS06735	COG0741	lytic transglycosylase activity
N646_RS06745	COG3021	interspecies interaction between organisms
N646_RS06750	COG0347	Belongs to the P(II) protein family
N646_RS06765	COG0825	malonyl-CoA metabolic process
N646_RS06770	COG0587	DNA-directed DNA polymerase activity
N646_RS06780	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
N646_RS06785	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
N646_RS06795	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
N646_RS06800	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
N646_RS06810	COG0750	zinc metalloprotease
N646_RS06815	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
N646_RS06820	COG0575	Belongs to the CDS family
N646_RS06825	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
N646_RS06830	COG0233	cytoplasmic translational termination
N646_RS06835	COG0528	UMP kinase activity
N646_RS06840	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
N646_RS06845	COG0052	Belongs to the universal ribosomal protein uS2 family
N646_RS06850	COG0024	Methionine aminopeptidase
N646_RS06855	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
N646_RS06865	COG0564	pseudouridine synthase activity
N646_RS06900	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
N646_RS06905	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
N646_RS06930	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
N646_RS06935	COG0254	rRNA binding
N646_RS06940	COG1720	tRNA m6t6A37 methyltransferase activity
N646_RS06945	COG0442	prolyl-tRNA aminoacylation
N646_RS06965	COG0733	neurotransmitter:sodium symporter activity
N646_RS06985	COG0514	ATP-dependent DNA helicase (RecQ)
N646_RS06990	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
N646_RS07015	COG2871	sodium ion transport
N646_RS07020	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
N646_RS07025	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
N646_RS07030	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
N646_RS07035	COG1805	sodium ion transport
N646_RS07040	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
N646_RS07050	COG0271	Belongs to the BolA IbaG family
N646_RS07055	COG2813	Specifically methylates the guanine in position
N646_RS07060	COG3056	Lipoprotein
N646_RS07080	COG1595	DNA-templated transcription, initiation
N646_RS07095	COG3248	Nucleoside-binding outer membrane protein
N646_RS07100	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
N646_RS07105	COG0693	protein deglycase activity
N646_RS07110	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
N646_RS07115	COG3706	GGDEF domain
N646_RS07120	COG2166	iron-sulfur cluster assembly
N646_RS07125	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
N646_RS07130	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
N646_RS07140	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
N646_RS07140	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
N646_RS07150	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
N646_RS07155	COG1074	ATP-dependent DNA helicase activity
N646_RS07165	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
N646_RS07185	COG3141	response to X-ray
N646_RS07200	COG2171	N-acyltransferase activity
N646_RS07205	COG0584	glycerophosphoryl diester phosphodiesterase
N646_RS07210	COG2271	Major facilitator Superfamily
N646_RS07215	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
N646_RS07220	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
N646_RS07225	COG1349	DNA-binding transcription factor activity
N646_RS07230	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
N646_RS07235	COG0598	Magnesium transport protein CorA
N646_RS07260	COG1609	Transcriptional regulator
N646_RS07265	COG0583	DNA-binding transcription factor activity
N646_RS07305	COG1022	Amp-dependent synthetase and ligase
N646_RS07310	COG0583	DNA-binding transcription factor activity
N646_RS07315	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
N646_RS07320	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
N646_RS07330	COG0560	Phosphoserine phosphatase
N646_RS07340	COG0813	purine-nucleoside phosphorylase activity
N646_RS07345	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
N646_RS07350	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
N646_RS07355	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
N646_RS07360	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
N646_RS07365	COG0084	hydrolase, TatD family'
N646_RS07395	COG3153	acetyltransferase
N646_RS07400	COG3154	lipid carrier protein
N646_RS07415	COG0826	peptidase U32
N646_RS07420	COG0826	peptidase U32
N646_RS07425	COG0534	Mate efflux family protein
N646_RS07440	COG1185	polyribonucleotide nucleotidyltransferase activity
N646_RS07445	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
N646_RS07450	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
N646_RS07455	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
N646_RS07460	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
N646_RS07465	COG0195	Participates in both transcription termination and antitermination
N646_RS07470	COG0779	Required for maturation of 30S ribosomal subunits
N646_RS07485	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
N646_RS07495	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N646_RS07500	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
N646_RS07505	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
N646_RS07510	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
N646_RS07515	COG1534	Rna-binding protein
N646_RS07520	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
N646_RS07525	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
N646_RS07530	COG2027	D-alanyl-D-alanine carboxypeptidase
N646_RS07540	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
N646_RS07570	COG0628	permease
N646_RS07580	COG0784	Response regulator, receiver
N646_RS07580	COG2205	protein histidine kinase activity
N646_RS07585	COG0747	negative chemotaxis
N646_RS07595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N646_RS07600	COG0444	Belongs to the ABC transporter superfamily
N646_RS07605	COG4608	Belongs to the ABC transporter superfamily
N646_RS07615	COG2971	BadF BadG BcrA BcrD
N646_RS07630	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N646_RS07635	COG3842	ATPase activity
N646_RS07645	COG1840	ABC-type Fe3 transport system, periplasmic component
N646_RS07650	COG0004	ammonium transporteR
N646_RS07660	COG3112	Uncharacterised protein family (UPF0231)
N646_RS07665	COG1049	propionate catabolic process, 2-methylcitrate cycle
N646_RS07670	COG1752	Esterase of the alpha-beta hydrolase superfamily
N646_RS07675	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
N646_RS07680	COG1643	Atp-dependent helicase
N646_RS07685	COG1489	DNA binding
N646_RS07695	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
N646_RS07705	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
N646_RS07710	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
N646_RS07715	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
N646_RS07720	COG1560	Kdo2-lipid A biosynthetic process
N646_RS07730	COG0842	Transport permease protein
N646_RS07735	COG1131	(ABC) transporter
N646_RS07740	COG0659	secondary active sulfate transmembrane transporter activity
N646_RS07745	COG0288	reversible hydration of carbon dioxide
N646_RS07760	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N646_RS07765	COG0508	dehydrogenase complex catalyzes the overall conversion of
N646_RS07770	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
N646_RS07775	COG2186	Transcriptional regulator
N646_RS07785	COG0157	Belongs to the NadC ModD family
N646_RS07795	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
N646_RS07800	COG1459	type II secretion system
N646_RS07810	COG0237	dephospho-CoA kinase activity
N646_RS07815	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
N646_RS07820	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
N646_RS07835	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
N646_RS07840	COG0228	four-way junction DNA binding
N646_RS07845	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
N646_RS07850	COG4137	Cytochrome C assembly protein
N646_RS07855	COG4536	flavin adenine dinucleotide binding
N646_RS07860	COG1854	S-ribosylhomocysteine lyase activity
N646_RS07875	COG0612	Peptidase, M16
N646_RS07880	COG1238	metal cluster binding
N646_RS07890	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
N646_RS07895	COG0511	ligase activity, forming carbon-carbon bonds
N646_RS07895	COG5016	pyruvate
N646_RS07900	COG3630	sodium ion export across plasma membrane
N646_RS07950	COG0527	aspartate kinase activity
N646_RS07955	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
N646_RS07960	COG2137	regulation of response to DNA damage stimulus
N646_RS07965	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
N646_RS07970	COG1546	Belongs to the CinA family
N646_RS07975	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
N646_RS07980	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
N646_RS07990	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
N646_RS07995	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
N646_RS08005	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
N646_RS08010	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
N646_RS08015	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
N646_RS08020	COG0148	phosphopyruvate hydratase activity
N646_RS08025	COG0504	CTP synthase activity
N646_RS08030	COG3956	TIGRFAM MazG family protein
N646_RS08035	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
N646_RS08040	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
N646_RS08050	COG0736	holo-[acyl-carrier-protein] synthase activity
N646_RS08055	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
N646_RS08060	COG1381	Involved in DNA repair and RecF pathway recombination
N646_RS08065	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
N646_RS08075	COG0681	Belongs to the peptidase S26 family
N646_RS08080	COG0481	GTPase activity
N646_RS08085	COG3086	response to oxidative stress
N646_RS08100	COG1595	DNA-templated transcription, initiation
N646_RS08105	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
N646_RS08110	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
N646_RS08130	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N646_RS08135	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N646_RS08140	COG3079	Belongs to the UPF0149 family
N646_RS08145	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
N646_RS08150	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
N646_RS08155	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
N646_RS08160	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
N646_RS08170	COG0583	DNA-binding transcription factor activity
N646_RS08185	COG0668	transmembrane transport
N646_RS08190	COG0191	fructose-bisphosphate aldolase activity
N646_RS08205	COG4771	TonB-dependent receptor
N646_RS08210	COG0583	DNA-binding transcription factor activity
N646_RS08215	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
N646_RS08220	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
N646_RS08235	COG2356	endonuclease I
N646_RS08240	COG1385	rRNA (uridine-N3-)-methyltransferase activity
N646_RS08245	COG0189	ligase activity
N646_RS08250	COG1678	Uncharacterized ACR, COG1678
N646_RS08255	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
N646_RS08270	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
N646_RS08275	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
N646_RS08280	COG0762	integral membrane protein
N646_RS08285	COG1872	DUF167
N646_RS08295	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
N646_RS08300	COG0635	Involved in the biosynthesis of porphyrin-containing compound
N646_RS08305	COG2066	Belongs to the glutaminase family
N646_RS08315	COG0220	tRNA (guanine-N7-)-methyltransferase activity
N646_RS08325	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
N646_RS08370	COG0840	transmembrane signaling receptor activity
N646_RS08445	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
N646_RS08450	COG1609	Transcriptional regulator
N646_RS08455	COG3394	polysaccharide catabolic process
N646_RS08460	COG1486	melibiose metabolic process
N646_RS08465	COG1447	Phosphotransferase system cellobiose-specific component IIA
N646_RS08470	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
N646_RS08475	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
N646_RS08480	COG0726	polysaccharide deacetylase
N646_RS08490	COG1028	Short-chain dehydrogenase reductase Sdr
N646_RS08505	COG0795	lipopolysaccharide-transporting ATPase activity
N646_RS08510	COG0795	lipopolysaccharide-transporting ATPase activity
N646_RS08515	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
N646_RS08520	COG2927	DNA polymerase III (CHI subunit)
N646_RS08525	COG0525	valine-tRNA ligase activity
N646_RS08535	COG0456	acetyltransferase
N646_RS08565	COG0540	Belongs to the ATCase OTCase family
N646_RS08570	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
N646_RS08575	COG0251	oxidation-reduction process
N646_RS08580	COG0204	Acyl-transferase
N646_RS08585	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
N646_RS08590	COG5007	Belongs to the BolA IbaG family
N646_RS08600	COG2854	intermembrane phospholipid transfer
N646_RS08605	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
N646_RS08610	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
N646_RS08615	COG1127	ABC transporter
N646_RS08625	COG0517	IMP dehydrogenase activity
N646_RS08625	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
N646_RS08635	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
N646_RS08640	COG1137	ATPase activity
N646_RS08650	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
N646_RS08655	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
N646_RS08660	COG1660	Displays ATPase and GTPase activities
N646_RS08665	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
N646_RS08670	COG2239	Acts as a magnesium transporter
N646_RS08675	COG0312	modulator of DNA gyrase
N646_RS08680	COG3028	Belongs to the UPF0307 family
N646_RS08685	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
N646_RS08690	COG0564	pseudouridine synthase activity
N646_RS08700	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
N646_RS08705	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
N646_RS08710	COG0312	modulator of DNA gyrase
N646_RS08715	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
N646_RS08720	COG3164	Protein of unknown function
N646_RS08730	COG0424	maF-like protein
N646_RS08735	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
N646_RS08740	COG1792	Involved in formation and maintenance of cell shape
N646_RS08745	COG1077	Cell shape determining protein MreB Mrl
N646_RS08780	COG2165	general secretion pathway protein
N646_RS08790	COG1459	type II secretion system
N646_RS08795	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
N646_RS08805	COG3409	Peptidoglycan-binding domain 1 protein
N646_RS08805	COG3267	Type II secretory pathway component ExeA
N646_RS08810	COG1450	Type ii and iii secretion system protein
N646_RS08830	COG2199	diguanylate cyclase activity
N646_RS08830	COG2200	EAL domain
N646_RS08835	COG0629	single-stranded DNA binding
N646_RS08850	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
N646_RS08860	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
N646_RS08870	COG0527	aspartate kinase activity
N646_RS08875	COG0646	methionine synthase
N646_RS08875	COG1410	methionine synthase
N646_RS08955	COG0175	sulfate reduction
N646_RS08960	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
N646_RS08965	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
N646_RS08985	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
N646_RS08990	COG0735	belongs to the Fur family
N646_RS09000	COG0166	Belongs to the GPI family
N646_RS09005	COG0432	Pfam Uncharacterised protein family UPF0047
N646_RS09010	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
N646_RS09035	COG2965	DNA replication, synthesis of RNA primer
N646_RS09040	COG0360	Binds together with S18 to 16S ribosomal RNA
N646_RS09045	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
N646_RS09050	COG0338	D12 class N6 adenine-specific DNA methyltransferase
N646_RS09060	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
N646_RS09065	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
N646_RS09095	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
N646_RS09105	COG0678	peroxiredoxin activity
N646_RS09105	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
N646_RS09110	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N646_RS09120	COG0165	Argininosuccinate lyase
N646_RS09120	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
N646_RS09125	COG0137	argininosuccinate synthase activity
N646_RS09135	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
N646_RS09145	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
N646_RS09155	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
N646_RS09160	COG0460	homoserine dehydrogenase
N646_RS09160	COG0527	aspartate kinase activity
N646_RS09165	COG0626	cystathionine gamma-synthase activity
N646_RS09170	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
N646_RS09175	COG0281	malic enzyme
N646_RS09190	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
N646_RS09195	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
N646_RS09215	COG2923	Belongs to the DsrF TusC family
N646_RS09220	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
N646_RS09225	COG2964	Protein conserved in bacteria
N646_RS09230	COG0545	Peptidyl-prolyl cis-trans isomerase
N646_RS09245	COG1446	asparaginase
N646_RS09250	COG1047	Peptidyl-prolyl cis-trans
N646_RS09265	COG2249	NAD(P)H dehydrogenase (quinone) activity
N646_RS09270	COG0488	(ABC) transporter
N646_RS09280	COG0429	hydrolase of the alpha beta-hydrolase fold
N646_RS09290	COG3954	Phosphoribulokinase
N646_RS09295	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
N646_RS09315	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
N646_RS09320	COG0512	Glutamine amidotransferase of anthranilate synthase
N646_RS09335	COG0180	Tryptophanyl-tRNA synthetase
N646_RS09340	COG0546	phosphoglycolate phosphatase activity
N646_RS09345	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
N646_RS09350	COG0557	exoribonuclease II activity
N646_RS09355	COG1959	2 iron, 2 sulfur cluster binding
N646_RS09360	COG1017	nitric oxide dioxygenase activity
N646_RS09360	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
N646_RS09365	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
N646_RS09370	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
N646_RS09375	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
N646_RS09380	COG0330	HflC and HflK could
N646_RS09385	COG0330	HflC and HflK could
N646_RS09390	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
N646_RS09400	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
N646_RS09405	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
N646_RS09415	COG0802	atpase or kinase
N646_RS09420	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
N646_RS09475	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
N646_RS09480	COG1162	GTPase activity
N646_RS09485	COG0688	phosphatidylethanolamine metabolic process
N646_RS09490	COG3273	potassium ion transport
N646_RS09490	COG0471	metal ion transport
N646_RS09500	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
N646_RS09505	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
N646_RS09510	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
N646_RS09515	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
N646_RS09520	COG1045	serine acetyltransferase
N646_RS09525	COG4942	peptidase
N646_RS09545	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
N646_RS09550	COG1053	succinate dehydrogenase
N646_RS09555	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
N646_RS09560	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
N646_RS09565	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
N646_RS09580	COG1509	lysine 2,3-aminomutase activity
N646_RS09585	COG1285	pathogenesis
N646_RS09595	COG0459	protein refolding
N646_RS09605	COG0534	Mate efflux family protein
N646_RS09615	COG0205	6-phosphofructokinase activity
N646_RS09625	COG3678	ATP-independent chaperone mediated protein folding
N646_RS09630	COG0745	RESPONSE REGULATOR receiver
N646_RS09635	COG2205	protein histidine kinase activity
N646_RS09645	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
N646_RS09650	COG3030	protein affecting phage T7 exclusion by the F plasmid
N646_RS09655	COG1027	Aspartate ammonia-lyase
N646_RS09660	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
N646_RS09665	COG4232	protein-disulfide reductase activity
N646_RS09675	COG3263	regulation of cellular component size
N646_RS09685	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
N646_RS09710	COG2814	Major facilitator Superfamily
N646_RS09725	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
N646_RS09730	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
N646_RS09735	COG0511	ligase activity, forming carbon-carbon bonds
N646_RS09740	COG0439	Biotin carboxylase
N646_RS09745	COG2264	protein methyltransferase activity
N646_RS09750	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
N646_RS09755	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
N646_RS09765	COG0488	(ABC) transporter
N646_RS09825	COG1982	Orn Lys Arg decarboxylase major
N646_RS09830	COG0531	amino acid
N646_RS09835	COG3710	Transcriptional regulator
N646_RS09840	COG0789	Transcriptional regulator
N646_RS09845	COG0138	bifunctional purine biosynthesis protein purh
N646_RS09850	COG0151	Belongs to the GarS family
N646_RS09865	COG1253	flavin adenine dinucleotide binding
N646_RS09870	COG3068	Protein conserved in bacteria
N646_RS09880	COG1573	uracil-dna glycosylase
N646_RS09885	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
N646_RS09890	COG2816	NAD+ diphosphatase activity
N646_RS09895	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
N646_RS09900	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
N646_RS09905	COG0085	RNA polymerase activity
N646_RS09910	COG0222	ribosome binding
N646_RS09915	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
N646_RS09930	COG0250	Participates in transcription elongation, termination and antitermination
N646_RS09935	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
N646_RS09940	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
N646_RS09970	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
N646_RS09970	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
N646_RS09975	COG0812	UDP-N-acetylmuramate dehydrogenase activity
N646_RS09985	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
N646_RS10035	COG4206	TonB-dependent receptor
N646_RS10080	COG3339	Conserved Protein
N646_RS10145	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N646_RS10150	COG0534	Mate efflux family protein
N646_RS10155	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
N646_RS10160	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
N646_RS10165	COG2937	Belongs to the GPAT DAPAT family
N646_RS10170	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
N646_RS10175	COG3161	chorismate lyase activity
N646_RS10180	COG1580	Controls the rotational direction of flagella during chemotaxis
N646_RS10185	COG0705	Rhomboid family
N646_RS10190	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
N646_RS10200	COG2177	Part of the ABC transporter FtsEX involved in
N646_RS10205	COG2884	Cell division ATP-binding protein ftsE
N646_RS10210	COG0552	protein localization to endoplasmic reticulum
N646_RS10215	COG0742	ribosomal rna small subunit methyltransferase
N646_RS10225	COG2095	MarC family integral membrane protein
N646_RS10265	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
N646_RS10270	COG0640	Transcriptional regulator
N646_RS10275	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
N646_RS10280	COG1280	lysine exporter protein (LysE YggA)
N646_RS10285	COG2267	carboxylic ester hydrolase activity
N646_RS10290	COG0561	phosphatase activity
N646_RS10305	COG3148	PFAM DTW domain containing protein
N646_RS10310	COG2199	diguanylate cyclase activity
N646_RS10310	COG2200	EAL domain
N646_RS10310	COG3287	FIST C domain
N646_RS10315	COG1011	Hydrolase
N646_RS10320	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
N646_RS10335	COG0019	diaminopimelate decarboxylase activity
N646_RS10345	COG1965	Belongs to the frataxin family
N646_RS10350	COG3072	Adenylate cyclase
N646_RS10355	COG0181	hydroxymethylbilane synthase activity
N646_RS10360	COG1587	Uroporphyrinogen-III synthase
N646_RS10365	COG2959	enzyme of heme biosynthesis
N646_RS10370	COG3071	HemY protein
N646_RS10415	COG0633	Ferredoxin
N646_RS10420	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
N646_RS10435	COG3118	belongs to the thioredoxin family
N646_RS10440	COG0513	Belongs to the DEAD box helicase family
N646_RS10445	COG0248	Ppx GppA phosphatase
N646_RS10455	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
N646_RS10465	COG0514	ATP-dependent DNA helicase (RecQ)
N646_RS10470	COG2962	Rard protein
N646_RS10480	COG1280	lysine exporter protein (LysE YggA)
N646_RS10485	COG0405	Gamma-glutamyltransferase
N646_RS10490	COG0210	DNA helicase
N646_RS10500	COG3220	belongs to the UPF0276 family
N646_RS10530	COG0006	proline dipeptidase activity
N646_RS10530	COG0006	proline dipeptidase activity
N646_RS10545	COG2104	thiamine diphosphate biosynthetic process
N646_RS10550	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
N646_RS10570	COG2132	Multicopper oxidase
N646_RS10615	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
N646_RS10635	COG0009	L-threonylcarbamoyladenylate synthase
N646_RS10640	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
N646_RS10645	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
N646_RS10650	COG0551	DNA topoisomerase type I activity
N646_RS10655	COG2922	Belongs to the Smg family
N646_RS10660	COG0758	DNA mediated transformation
N646_RS10670	COG0242	peptide deformylase activity
N646_RS10675	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
N646_RS10680	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
N646_RS10680	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
N646_RS10685	COG0569	domain protein
N646_RS10690	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
N646_RS10700	COG1272	protein, Hemolysin III
N646_RS10705	COG4326	sporulation control protein
N646_RS10710	COG3084	Protein conserved in bacteria
N646_RS10720	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
N646_RS10725	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
N646_RS10730	COG0204	Acyl-transferase
N646_RS10740	COG0606	chelatase, subunit chli
N646_RS10750	COG3978	acetolactate synthase activity
N646_RS10755	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
N646_RS10760	COG0129	dihydroxy-acid dehydratase activity
N646_RS10770	COG0583	DNA-binding transcription factor activity
N646_RS10775	COG2814	Major facilitator Superfamily
N646_RS10780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N646_RS10785	COG0765	amino acid transport
N646_RS10795	COG0355	proton-transporting ATP synthase activity, rotational mechanism
N646_RS10800	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
N646_RS10805	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
N646_RS10810	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
N646_RS10815	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
N646_RS10820	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
N646_RS10830	COG0356	it plays a direct role in the translocation of protons across the membrane
N646_RS10835	COG3312	ion transport
N646_RS10840	COG1475	DNA binding
N646_RS10845	COG1192	Involved in chromosome partitioning
N646_RS10850	COG0357	Ribosomal RNA small subunit methyltransferase G
N646_RS10855	COG0445	tRNA wobble uridine modification
N646_RS10860	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
N646_RS10870	COG0706	membrane insertase activity
N646_RS10875	COG0594	ribonuclease P activity
N646_RS10885	COG1126	abc transporter atp-binding protein
N646_RS10900	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
N646_RS10905	COG0592	DNA-directed DNA polymerase activity
N646_RS10915	COG0187	DNA topoisomerase II activity
N646_RS10935	COG0071	Belongs to the small heat shock protein (HSP20) family
N646_RS10940	COG3977	Valine--pyruvate aminotransferase
N646_RS10945	COG0366	Alpha amylase catalytic
N646_RS10960	COG2119	membrane
N646_RS10970	COG0425	Belongs to the sulfur carrier protein TusA family
N646_RS10985	COG0604	alcohol dehydrogenase
N646_RS10990	COG0183	Belongs to the thiolase family
N646_RS11000	COG1739	Uncharacterized protein family UPF0029
N646_RS11005	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
N646_RS11040	COG0583	DNA-binding transcription factor activity
N646_RS11045	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
N646_RS11050	COG2960	long-chain fatty acid transporting porin activity
N646_RS11055	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
N646_RS11060	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N646_RS11115	COG4166	transmembrane transport
N646_RS11120	COG0601	transmembrane transport
N646_RS11125	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N646_RS11160	COG1609	Transcriptional regulator
N646_RS11165	COG0583	DNA-binding transcription factor activity
N646_RS11180	COG0129	dihydroxy-acid dehydratase activity
N646_RS11185	COG3265	gluconokinase activity
N646_RS11190	COG2610	gluconate transmembrane transporter activity
N646_RS11195	COG0800	Aldolase
N646_RS11200	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
N646_RS11205	COG0583	DNA-binding transcription factor activity
N646_RS11245	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N646_RS11250	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
N646_RS11260	COG1522	sequence-specific DNA binding
N646_RS11265	COG5002	protein histidine kinase activity
N646_RS11265	COG5001	Diguanylate cyclase
N646_RS11270	COG0742	ribosomal rna small subunit methyltransferase
N646_RS11285	COG0589	response to stress
N646_RS11290	COG1528	Iron-storage protein
N646_RS11300	COG2081	HI0933 family
N646_RS11330	COG1597	lipid kinase activity
N646_RS11360	COG0628	permease
N646_RS11375	COG1322	Protein conserved in bacteria
N646_RS11380	COG2226	methyltransferase
N646_RS11385	COG3165	ubiquinone biosynthetic process from chorismate
N646_RS11390	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
N646_RS11400	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
N646_RS11405	COG0805	protein transport
N646_RS11420	COG0084	hydrolase, TatD family'
N646_RS11430	COG0456	acetyltransferase
N646_RS11435	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
N646_RS11435	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
N646_RS11440	COG0218	Necessary for normal cell division and for the maintenance of normal septation
N646_RS11470	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
N646_RS11480	COG2204	response regulator
N646_RS11485	COG3852	Histidine kinase
N646_RS11495	COG0174	glutamine synthetase
N646_RS11500	COG1217	gtp-binding protein TYPA
N646_RS11505	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
N646_RS11515	COG1295	ribonuclease BN
N646_RS11520	COG1490	D-aminoacyl-tRNA deacylase activity
N646_RS11525	COG0456	acetyltransferase
N646_RS11535	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
N646_RS11540	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
N646_RS11545	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
N646_RS11550	COG3031	protein transport across the cell outer membrane
N646_RS11560	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
N646_RS11565	COG1459	type II secretion system
N646_RS11570	COG2165	general secretion pathway protein
N646_RS11575	COG2165	general secretion pathway protein
N646_RS11580	COG2165	general secretion pathway protein
N646_RS11585	COG4795	General secretion pathway protein
N646_RS11590	COG3156	type II secretion system protein K
N646_RS11595	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
N646_RS11600	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
N646_RS11610	COG1218	3'(2'),5'-bisphosphate nucleotidase
N646_RS11615	COG0494	nUDIX hydrolase
N646_RS11625	COG1040	competence protein
N646_RS11640	COG2183	response to ionizing radiation
N646_RS11650	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
N646_RS11670	COG2233	PERMEase
N646_RS11675	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
N646_RS11680	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
N646_RS11685	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
N646_RS11695	COG0194	GDP metabolic process
N646_RS11710	COG0848	biopolymer transport protein
N646_RS11715	COG0811	peptide transport
N646_RS11735	COG4174	ABC transporter (Permease)
N646_RS11740	COG4239	(ABC) transporter, permease
N646_RS11745	COG0747	negative chemotaxis
N646_RS11750	COG0444	Belongs to the ABC transporter superfamily
N646_RS11755	COG4608	Belongs to the ABC transporter superfamily
N646_RS11765	COG1561	YicC-like family, N-terminal region
N646_RS11770	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
N646_RS11775	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
N646_RS11780	COG1560	Kdo2-lipid A biosynthetic process
N646_RS11785	COG1309	transcriptional regulator
N646_RS11790	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
N646_RS11800	COG2003	Belongs to the UPF0758 family
N646_RS11825	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
N646_RS11840	COG0463	Glycosyl transferase, family 2
N646_RS11845	COG0859	PFAM glycosyl transferase family 9
N646_RS11850	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
N646_RS11855	COG3642	lipopolysaccharide core region biosynthetic process
N646_RS11865	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
N646_RS11905	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
N646_RS11910	COG1519	Transferase
N646_RS11915	COG0859	PFAM glycosyl transferase family 9
N646_RS11925	COG1560	Kdo2-lipid A biosynthetic process
N646_RS11935	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
N646_RS11970	COG2244	polysaccharide biosynthetic process
N646_RS11985	COG0438	transferase activity, transferring glycosyl groups
N646_RS12010	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
N646_RS12020	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
N646_RS12030	COG0812	UDP-N-acetylmuramate dehydrogenase activity
N646_RS12050	COG0438	transferase activity, transferring glycosyl groups
N646_RS12085	COG0149	triose-phosphate isomerase activity
N646_RS12095	COG3152	Membrane
N646_RS12115	COG1494	fructose-1,6-bisphosphatase
N646_RS12125	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
N646_RS12130	COG1575	Belongs to the MenA family. Type 1 subfamily
N646_RS12135	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
N646_RS12140	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
N646_RS12150	COG1609	Transcriptional regulator
N646_RS12155	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
N646_RS12160	COG0254	rRNA binding
N646_RS12170	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
N646_RS12175	COG0088	Forms part of the polypeptide exit tunnel
N646_RS12185	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
N646_RS12190	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
N646_RS12195	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
N646_RS12200	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
N646_RS12210	COG0255	Belongs to the universal ribosomal protein uL29 family
N646_RS12215	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
N646_RS12225	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
N646_RS12230	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
N646_RS12240	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
N646_RS12245	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
N646_RS12260	COG1841	ribosomal large subunit assembly
N646_RS12265	COG0200	Binds to the 23S rRNA
N646_RS12270	COG0201	protein transport
N646_RS12275	COG0257	Belongs to the bacterial ribosomal protein bL36 family
N646_RS12280	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
N646_RS12285	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
N646_RS12295	COG0202	RNA polymerase activity
N646_RS12300	COG0203	ribosomal protein L17
N646_RS12310	COG0545	Peptidyl-prolyl cis-trans isomerase
N646_RS12320	COG2153	protein acetylation
N646_RS12325	COG0513	Belongs to the DEAD box helicase family
N646_RS12340	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
N646_RS12340	COG1648	precorrin-2 dehydrogenase activity
N646_RS12345	COG0175	sulfate reduction
N646_RS12350	COG2895	sulfate adenylyltransferase (ATP) activity
N646_RS12355	COG0471	metal ion transport
N646_RS12355	COG3273	potassium ion transport
N646_RS12360	COG0529	Catalyzes the synthesis of activated sulfate
N646_RS12380	COG4181	ATPase activity
N646_RS12395	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
N646_RS12405	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N646_RS12410	COG0729	surface antigen
N646_RS12415	COG2911	Protein conserved in bacteria
N646_RS12420	COG2105	PFAM AIG2 family protein
N646_RS12430	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
N646_RS12435	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
N646_RS12440	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
N646_RS12445	COG0163	prenyltransferase activity
N646_RS12450	COG4143	(ABC) transporter
N646_RS12455	COG1178	ABC-type Fe3 transport system permease component
N646_RS12460	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
N646_RS12465	COG0583	DNA-binding transcription factor activity
N646_RS12470	COG1902	pentaerythritol trinitrate reductase activity
N646_RS12485	COG2358	TRAP transporter, solute receptor (TAXI family
N646_RS12505	COG0142	geranyltranstransferase activity
N646_RS12510	COG0261	This protein binds to 23S rRNA in the presence of protein L20
N646_RS12520	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
N646_RS12525	COG2966	Psort location CytoplasmicMembrane, score
N646_RS12535	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
N646_RS12540	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
N646_RS12545	COG2967	ApaG domain
N646_RS12550	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
N646_RS12555	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
N646_RS12560	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
N646_RS12565	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
N646_RS12570	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
N646_RS12590	COG0473	3-isopropylmalate dehydrogenase activity
N646_RS12595	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
N646_RS12615	COG0583	DNA-binding transcription factor activity
N646_RS12620	COG1022	Amp-dependent synthetase and ligase
N646_RS12625	COG0028	Belongs to the TPP enzyme family
N646_RS12630	COG0440	acetolactate synthase activity
N646_RS12645	COG0469	pyruvate kinase activity
N646_RS12650	COG1349	DNA-binding transcription factor activity
N646_RS12655	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
N646_RS12665	COG2376	Dihydroxyacetone kinase
N646_RS12670	COG1461	Dihydroxyacetone kinase
N646_RS12685	COG3722	fumarate hydratase activity
N646_RS12695	COG2213	PTS system mannitol-specific
N646_RS12695	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
N646_RS12715	COG1464	Belongs to the NlpA lipoprotein family
N646_RS12730	COG0358	DNA primase activity
N646_RS12735	COG1610	YqeY-like protein
N646_RS12740	COG0828	Belongs to the bacterial ribosomal protein bS21 family
N646_RS12745	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
N646_RS12750	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
N646_RS12755	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
N646_RS12760	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
N646_RS12765	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
N646_RS12770	COG1968	undecaprenyl-diphosphatase activity
N646_RS12780	COG3267	Type II secretory pathway component ExeA
N646_RS12780	COG3409	Peptidoglycan-binding domain 1 protein
N646_RS12790	COG0405	Gamma-glutamyltransferase
N646_RS12795	COG4991	sh3 domain protein
N646_RS12800	COG0306	phosphate transporter
N646_RS12805	COG1392	Phosphate transport regulator
N646_RS12810	COG3025	triphosphatase activity
N646_RS12825	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
N646_RS12830	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
N646_RS12830	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
N646_RS12835	COG1538	Outer membrane efflux protein
N646_RS12840	COG0494	nUDIX hydrolase
N646_RS12845	COG3151	Protein conserved in bacteria
N646_RS12855	COG3150	esterase
N646_RS12865	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
N646_RS12870	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N646_RS12880	COG3105	Protein conserved in bacteria
N646_RS12885	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
N646_RS12895	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
N646_RS12900	COG0723	plastoquinol--plastocyanin reductase activity
N646_RS12905	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
N646_RS12910	COG2857	Cytochrome c1
N646_RS12915	COG0625	glutathione transferase activity
N646_RS12920	COG2969	positive regulation of protein catabolic process
N646_RS12925	COG2823	Periplasmic or secreted lipoprotein
N646_RS12930	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
N646_RS12945	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
N646_RS12955	COG3116	cell division
N646_RS12960	COG0768	penicillin binding
N646_RS12965	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
N646_RS12970	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
N646_RS12975	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
N646_RS12980	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
N646_RS12985	COG0772	Belongs to the SEDS family
N646_RS13000	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
N646_RS13005	COG0849	cell division
N646_RS13010	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
N646_RS13015	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
N646_RS13025	COG0653	protein targeting
N646_RS13030	COG0494	nUDIX hydrolase
N646_RS13040	COG0505	Belongs to the CarA family
N646_RS13045	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
N646_RS13060	COG0730	response to heat
N646_RS13065	COG0583	DNA-binding transcription factor activity
N646_RS13070	COG2860	membrane
N646_RS13085	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
N646_RS13095	COG0493	'glutamate synthase
N646_RS13100	COG0067	glutamate synthase
N646_RS13100	COG0069	glutamate synthase activity
N646_RS13100	COG0070	glutamate synthase
N646_RS13110	COG0069	glutamate synthase activity
N646_RS13110	COG0070	glutamate synthase
N646_RS13110	COG0067	glutamate synthase
N646_RS13115	COG1242	4 iron, 4 sulfur cluster binding
N646_RS13120	COG5001	Diguanylate cyclase
N646_RS13120	COG3706	GGDEF domain
N646_RS13120	COG4251	negative regulation of phosphorylation
N646_RS13120	COG2203	Gaf domain
N646_RS13125	COG5002	protein histidine kinase activity
N646_RS13125	COG2198	Histidine kinase
N646_RS13125	COG0784	Response regulator, receiver
N646_RS13135	COG0745	RESPONSE REGULATOR receiver
N646_RS13145	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
N646_RS13160	COG0083	homoserine kinase activity
N646_RS13165	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
N646_RS13175	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
N646_RS13180	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
N646_RS13185	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
N646_RS13200	COG1115	amino acid carrier protein
N646_RS13205	COG3022	response to hydroperoxide
N646_RS13210	COG0513	Belongs to the DEAD box helicase family
N646_RS13215	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
N646_RS13225	COG0716	FMN binding
N646_RS13230	COG4974	Belongs to the 'phage' integrase family
N646_RS13235	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
N646_RS13240	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
N646_RS13245	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
N646_RS13255	COG2204	response regulator
N646_RS13265	COG0667	Aldo Keto reductase
N646_RS13290	COG0730	response to heat
N646_RS13295	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
N646_RS13300	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
N646_RS13310	COG1283	sodium-dependent phosphate transmembrane transporter activity
N646_RS13315	COG0583	DNA-binding transcription factor activity
N646_RS13320	COG0640	Transcriptional regulator
N646_RS13325	COG0268	Binds directly to 16S ribosomal RNA
N646_RS13330	COG0728	peptidoglycan biosynthetic process
N646_RS13335	COG0196	riboflavin kinase activity
N646_RS13350	COG1047	Peptidyl-prolyl cis-trans
N646_RS13355	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
N646_RS13365	COG3279	Response regulator of the LytR AlgR family
N646_RS13370	COG3275	phosphorelay sensor kinase activity
N646_RS13375	COG1966	Carbon starvation protein
N646_RS13395	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
N646_RS13400	COG1472	Belongs to the glycosyl hydrolase 3 family
N646_RS13405	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
N646_RS13410	COG0287	Prephenate dehydrogenase
N646_RS13410	COG1605	Chorismate mutase
N646_RS13415	COG0739	heme binding
N646_RS13425	COG0488	(ABC) transporter
N646_RS13435	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
N646_RS13440	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
N646_RS13445	COG0077	Prephenate dehydratase
N646_RS13445	COG1605	Chorismate mutase
N646_RS13460	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
N646_RS13465	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
N646_RS13470	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
N646_RS13475	COG0564	pseudouridine synthase activity
N646_RS13485	COG0542	response to heat
N646_RS13540	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
N646_RS13545	COG0826	peptidase U32
N646_RS13550	COG2974	May be involved in recombination
N646_RS13555	COG0745	RESPONSE REGULATOR receiver
N646_RS13560	COG5002	protein histidine kinase activity
N646_RS13575	COG0248	Ppx GppA phosphatase
N646_RS13580	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
N646_RS13585	COG0573	inorganic phosphate transmembrane transporter activity
N646_RS13590	COG0581	inorganic phosphate transmembrane transporter activity
N646_RS13595	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
N646_RS13600	COG0704	Plays a role in the regulation of phosphate uptake
N646_RS13610	COG3142	Participates in the control of copper homeostasis
N646_RS13615	COG0450	alkyl hydroperoxide reductase
N646_RS13620	COG0583	DNA-binding transcription factor activity
N646_RS13625	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
N646_RS13635	COG0517	IMP dehydrogenase activity
N646_RS13645	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
N646_RS13655	COG1862	Preprotein translocase
N646_RS13660	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
N646_RS13665	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
N646_RS13680	COG0483	inositol monophosphate 1-phosphatase activity
N646_RS13685	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
N646_RS13700	COG0822	iron-sulfur transferase activity
N646_RS13715	COG0443	Heat shock 70 kDa protein
N646_RS13720	COG0633	Ferredoxin
N646_RS13725	COG2975	iron-sulfur cluster assembly
N646_RS13735	COG0105	UTP biosynthetic process
N646_RS13750	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
N646_RS13755	COG0124	histidyl-tRNA synthetase
N646_RS13760	COG2976	Protein conserved in bacteria
N646_RS13765	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
N646_RS13770	COG1160	GTP binding
N646_RS13790	COG0516	GMP reductase activity
N646_RS13790	COG0517	IMP dehydrogenase activity
N646_RS13795	COG0519	Catalyzes the synthesis of GMP from XMP
N646_RS13795	COG0518	GMP synthase (glutamine-hydrolyzing) activity
N646_RS13800	COG1757	Na H antiporter
N646_RS13810	COG1584	GPR1 FUN34 yaaH family protein
N646_RS13815	COG1115	amino acid carrier protein
N646_RS13830	COG2873	o-acetylhomoserine
N646_RS13835	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
N646_RS13855	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
N646_RS13855	COG3153	acetyltransferase
N646_RS13860	COG0583	DNA-binding transcription factor activity
N646_RS13900	COG0328	RNA-DNA hybrid ribonuclease activity
N646_RS13910	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
N646_RS13915	COG2867	negative regulation of translational initiation
N646_RS13920	COG2914	Belongs to the UPF0125 (RnfH) family
N646_RS13925	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
N646_RS13935	COG0497	DNA recombination
N646_RS13945	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
N646_RS13950	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
N646_RS13955	COG1301	dicarboxylic acid transport
N646_RS13965	COG0484	heat shock protein binding
N646_RS13995	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
N646_RS14005	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
N646_RS14010	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
N646_RS14010	COG0047	phosphoribosylformylglycinamidine synthase activity
N646_RS14040	COG2195	Cleaves the N-terminal amino acid of tripeptides
N646_RS14045	COG2252	PERMEase
N646_RS14050	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
N646_RS14055	COG1073	alpha beta
N646_RS14065	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
N646_RS14070	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
N646_RS14075	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
N646_RS14080	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
N646_RS14080	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
N646_RS14095	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
N646_RS14105	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
N646_RS14110	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
N646_RS14115	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
N646_RS14120	COG0142	geranyltranstransferase activity
N646_RS14125	COG1722	exodeoxyribonuclease VII activity
N646_RS14130	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
N646_RS14140	COG0301	tRNA thio-modification
N646_RS14140	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
N646_RS14145	COG0583	DNA-binding transcription factor activity
N646_RS14155	COG2363	Small membrane protein
N646_RS14175	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
N646_RS14180	COG1611	Belongs to the LOG family
N646_RS14195	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
N646_RS14195	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
N646_RS14205	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
N646_RS14210	COG1464	Belongs to the NlpA lipoprotein family
N646_RS14215	COG2011	ABC-type metal ion transport system permease component
N646_RS14220	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
N646_RS14225	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
N646_RS14235	COG1263	PTS System
N646_RS14235	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N646_RS14240	COG0366	Alpha amylase catalytic
N646_RS14255	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
N646_RS14260	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
N646_RS14265	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
N646_RS14270	COG0321	lipoyl(octanoyl) transferase activity
N646_RS14280	COG1686	Belongs to the peptidase S11 family
N646_RS14285	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
N646_RS14290	COG0772	Belongs to the SEDS family
N646_RS14295	COG0768	penicillin binding
N646_RS14300	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
N646_RS14305	COG0799	negative regulation of ribosome biogenesis
N646_RS14310	COG1466	dna polymerase III delta subunit
N646_RS14315	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
N646_RS14320	COG0495	leucyl-tRNA aminoacylation
N646_RS14325	COG2888	peptidyl-tyrosine sulfation
N646_RS14330	COG0815	Transfers the fatty acyl group on membrane lipoproteins
N646_RS14335	COG4535	Mg2 and Co2 transporter CorC
N646_RS14340	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
N646_RS14345	COG1702	phosphate starvation-inducible protein PhoH
N646_RS14350	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
N646_RS14355	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N646_RS14385	COG0012	GTP binding
N646_RS14390	COG0193	aminoacyl-tRNA hydrolase activity
N646_RS14395	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
N646_RS14400	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
N646_RS14405	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
N646_RS14410	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
N646_RS14420	COG2890	protein-(glutamine-N5) methyltransferase activity
N646_RS14425	COG3094	Invasion gene expression up-regulator, SirB
N646_RS14430	COG2912	Transglutaminase-like superfamily
N646_RS14435	COG2877	3-deoxy-8-phosphooctulonate synthase activity
N646_RS14440	COG0737	Belongs to the 5'-nucleotidase family
N646_RS14445	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
N646_RS14450	COG1187	pseudouridine synthase activity
N646_RS14455	COG2840	Smr protein MutS2
N646_RS14495	COG2217	Heavy metal translocating P-type atpase
N646_RS14495	COG2608	mercury ion transmembrane transporter activity
N646_RS14505	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
N646_RS14560	COG0784	Response regulator, receiver
N646_RS14560	COG0835	chemotaxis
N646_RS14565	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
N646_RS14570	COG1815	bacterial-type flagellum-dependent cell motility
N646_RS14575	COG1558	bacterial-type flagellum-dependent cell motility
N646_RS14585	COG1749	Flagellar hook protein flgE
N646_RS14590	COG4787	bacterial-type flagellum-dependent cell motility
N646_RS14600	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
N646_RS14605	COG1706	bacterial-type flagellum-dependent cell motility
N646_RS14610	COG3951	Flagellar rod assembly protein muramidase FlgJ
N646_RS14610	COG1705	Flagellar rod assembly protein muramidase FlgJ
N646_RS14620	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
N646_RS14625	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
N646_RS14635	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
N646_RS14640	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
N646_RS14645	COG2190	(PTS) system
N646_RS14650	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
N646_RS14655	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
N646_RS14660	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
N646_RS14665	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
N646_RS14670	COG3115	cell septum assembly
N646_RS14675	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
N646_RS14690	COG0330	HflC and HflK could
N646_RS14695	COG2194	sulfuric ester hydrolase activity
N646_RS14710	COG1192	Involved in chromosome partitioning
N646_RS14715	COG1215	transferase activity, transferring glycosyl groups
N646_RS14720	COG1215	transferase activity, transferring glycosyl groups
N646_RS14725	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
N646_RS14735	COG3118	belongs to the thioredoxin family
N646_RS14740	COG0300	oxidoreductase activity
N646_RS14745	COG1090	epimerase
N646_RS14770	COG0622	Phosphoesterase
N646_RS14790	COG3710	Transcriptional regulator
N646_RS14795	COG0326	Molecular chaperone. Has ATPase activity
N646_RS14805	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
N646_RS14810	COG3104	oligopeptide transport
N646_RS14815	COG0250	Participates in transcription elongation, termination and antitermination
N646_RS14820	COG0367	asparagine synthase
N646_RS14825	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
N646_RS14825	COG4651	solute:proton antiporter activity
N646_RS14830	COG1846	Transcriptional regulator
N646_RS14830	COG1940	carbohydrate kinase activity
N646_RS14835	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
N646_RS14840	COG2190	(PTS) system
N646_RS14840	COG1263	PTS System
N646_RS14840	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N646_RS14845	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
N646_RS14850	COG0735	belongs to the Fur family
N646_RS14860	COG0716	FMN binding
N646_RS14870	COG0596	Alpha beta hydrolase
N646_RS14875	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
N646_RS14880	COG0033	Phosphoglucomutase
N646_RS14890	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
N646_RS14905	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
N646_RS14910	COG1053	succinate dehydrogenase
N646_RS14915	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
N646_RS14920	COG0567	Dehydrogenase, E1 component
N646_RS14925	COG0508	dehydrogenase complex catalyzes the overall conversion of
N646_RS14930	COG0045	succinate-CoA ligase (ADP-forming) activity
N646_RS14940	COG1108	ABC-type Mn2 Zn2 transport systems permease components
N646_RS14945	COG1121	(ABC) transporter
N646_RS14950	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
N646_RS14955	COG4977	sequence-specific DNA binding
N646_RS14960	COG1918	ferrous iron import across plasma membrane
N646_RS14985	COG0018	arginyl-trna synthetase
N646_RS14990	COG3102	Protein conserved in bacteria
N646_RS15005	COG0788	formyltetrahydrofolate deformylase activity
N646_RS15010	COG1199	ATP-dependent helicase activity
N646_RS15015	COG1214	PFAM Peptidase M22, glycoprotease
N646_RS15025	COG3065	identical protein binding
N646_RS15030	COG2267	carboxylic ester hydrolase activity
N646_RS15035	COG0318	PFAM AMP-dependent synthetase and ligase
N646_RS15040	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
N646_RS15045	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
N646_RS15050	COG2894	cell division
N646_RS15055	COG0850	regulation of cytokinetic process
N646_RS15060	COG3100	YcgL domain-containing protein
N646_RS15065	COG2951	lytic endotransglycosylase activity
N646_RS15075	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
N646_RS15080	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
N646_RS15095	COG1028	Short-chain dehydrogenase reductase Sdr
N646_RS15105	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
N646_RS15130	COG2986	histidine ammonia-lyase
N646_RS15135	COG1216	Glycosyl transferase, family 2
N646_RS15140	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
N646_RS15155	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
N646_RS15160	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
N646_RS15195	COG0513	Belongs to the DEAD box helicase family
N646_RS15200	COG0569	domain protein
N646_RS15205	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
N646_RS15220	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
N646_RS15225	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
N646_RS15230	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
N646_RS15235	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
N646_RS15250	COG0544	peptidyl-prolyl cis-trans isomerase activity
N646_RS15260	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
N646_RS15265	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
N646_RS15270	COG0776	regulation of translation
N646_RS15275	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
N646_RS15280	COG1555	photosystem II stabilization
N646_RS15295	COG0232	Belongs to the dGTPase family. Type 2 subfamily
N646_RS15300	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
N646_RS15305	COG0436	Aminotransferase
N646_RS15495	COG0840	transmembrane signaling receptor activity
N646_RS15565	COG4591	ABC-type transport system involved in lipoprotein release permease component
N646_RS15575	COG0658	competence protein
N646_RS15575	COG2333	competence protein COMEC
N646_RS16085	COG0686	Belongs to the AlaDH PNT family
N646_RS16100	COG1674	ftsk spoiiie
N646_RS16235	COG1757	Na H antiporter
N646_RS16525	COG3604	Transcriptional regulator
N646_RS16770	COG1643	Atp-dependent helicase
N646_RS17255	COG2957	Belongs to the agmatine deiminase family
N646_RS17315	COG0784	Response regulator, receiver
N646_RS17315	COG2205	protein histidine kinase activity
N646_RS17330	COG5001	Diguanylate cyclase
N646_RS18155	COG3852	Histidine kinase
N646_RS18315	COG2217	Heavy metal translocating P-type atpase
N646_RS18320	COG2217	Heavy metal translocating P-type atpase
N646_RS18370	COG2205	protein histidine kinase activity
N646_RS18370	COG0784	Response regulator, receiver
N646_RS18485	COG2902	Dehydrogenase
N646_RS19405	COG2272	Belongs to the type-B carboxylesterase lipase family
N646_RS19925	COG0017	Asparaginyl-tRNA synthetase
N646_RS20140	COG0019	diaminopimelate decarboxylase activity
N646_RS20200	COG0417	DNA replication proofreading
N646_RS20470	COG3008	intermembrane lipid transfer
N646_RS20470	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
N646_RS20695	COG1530	ribonuclease E activity
N646_RS20835	COG0435	Glutathione S-transferase
N646_RS20930	COG4658	electron transport chain
N646_RS21275	COG0616	signal peptide processing
N646_RS21470	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N646_RS21470	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
N646_RS21570	COG2067	long-chain fatty acid transport protein
N646_RS21760	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
N646_RS22290	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
N646_RS22335	COG2171	N-acyltransferase activity
N646_RS22465	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
N646_RS22660	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
N646_RS22785	COG1049	propionate catabolic process, 2-methylcitrate cycle
N646_RS22820	COG1643	Atp-dependent helicase
N646_RS23030	COG0612	Peptidase, M16
N646_RS23195	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
N646_RS23215	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases