locus-tag	class	description
B5S57_RS00070	COG1192	Involved in chromosome partitioning
B5S57_RS00095	COG3657	addiction module killer protein
B5S57_RS00120	COG2433	Pfam Transposase IS66
B5S57_RS00145	COG0076	glutamate decarboxylase activity
B5S57_RS00180	COG4774	siderophore transport
B5S57_RS00185	COG4607	ABC-type enterochelin transport system periplasmic component
B5S57_RS00190	COG4605	iron ion homeostasis
B5S57_RS00195	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B5S57_RS00210	COG1028	Short-chain dehydrogenase reductase Sdr
B5S57_RS00280	COG2433	Pfam Transposase IS66
B5S57_RS00295	COG1169	isochorismate synthase
B5S57_RS00300	COG1021	2,3-dihydroxybenzoate-AMP ligase
B5S57_RS00305	COG3433	isochorismatase activity
B5S57_RS00305	COG1535	isochorismatase
B5S57_RS00380	COG2433	Pfam Transposase IS66
B5S57_RS00480	COG2433	Pfam Transposase IS66
B5S57_RS00485	COG1162	GTPase activity
B5S57_RS00495	COG2226	methyltransferase
B5S57_RS00505	COG0861	Integral membrane protein TerC family
B5S57_RS00515	COG2249	NAD(P)H dehydrogenase (quinone) activity
B5S57_RS00520	COG0656	L-ascorbic acid biosynthetic process
B5S57_RS00545	COG1566	PFAM secretion protein HlyD family protein
B5S57_RS00565	COG0509	glycine decarboxylation via glycine cleavage system
B5S57_RS00570	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B5S57_RS00580	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B5S57_RS00595	COG0612	Peptidase, M16
B5S57_RS00610	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B5S57_RS00610	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B5S57_RS00610	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
B5S57_RS00615	COG1105	Belongs to the carbohydrate kinase PfkB family
B5S57_RS00620	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B5S57_RS00620	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
B5S57_RS00625	COG1609	Transcriptional regulator
B5S57_RS00630	COG0420	3'-5' exonuclease activity
B5S57_RS00635	COG0419	ATPase involved in DNA repair
B5S57_RS00640	COG2205	protein histidine kinase activity
B5S57_RS00640	COG0784	Response regulator, receiver
B5S57_RS00645	COG0156	8-amino-7-oxononanoate synthase activity
B5S57_RS00655	COG0038	chloride channel
B5S57_RS00660	COG0523	cobalamin synthesis protein
B5S57_RS00665	COG1136	(ABC) transporter
B5S57_RS00675	COG1136	(ABC) transporter
B5S57_RS00675	COG0577	efflux transmembrane transporter activity
B5S57_RS00690	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
B5S57_RS00700	COG3675	Pfam Lipase (class 3)
B5S57_RS00720	COG3730	PTS system glucitol sorbitol-specific
B5S57_RS00735	COG1028	Short-chain dehydrogenase reductase Sdr
B5S57_RS00740	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
B5S57_RS00745	COG1349	DNA-binding transcription factor activity
B5S57_RS00750	COG3730	PTS system glucitol sorbitol-specific
B5S57_RS00765	COG3842	ATPase activity
B5S57_RS00775	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B5S57_RS00785	COG2182	Extracellular solute-binding protein
B5S57_RS00790	COG1175	transmembrane transport
B5S57_RS00795	COG3833	ABC-type maltose transport systems, permease component
B5S57_RS00820	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B5S57_RS00825	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B5S57_RS00835	COG3005	denitrification pathway
B5S57_RS00845	COG0243	molybdopterin cofactor binding
B5S57_RS00855	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
B5S57_RS00860	COG3850	Histidine kinase
B5S57_RS00865	COG2197	response regulator
B5S57_RS00870	COG3069	C4-dicarboxylate transmembrane transporter activity
B5S57_RS00895	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
B5S57_RS00905	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
B5S57_RS00910	COG0513	Belongs to the DEAD box helicase family
B5S57_RS00940	COG2433	Pfam Transposase IS66
B5S57_RS00975	COG2433	Pfam Transposase IS66
B5S57_RS00990	COG2433	Pfam Transposase IS66
B5S57_RS01215	COG3040	lipid binding
B5S57_RS01290	COG2433	Pfam Transposase IS66
B5S57_RS01320	COG0724	RNA recognition motif
B5S57_RS01460	COG0023	Translation Initiation Factor
B5S57_RS01475	COG1181	Belongs to the D-alanine--D-alanine ligase family
B5S57_RS01485	COG0045	succinate-CoA ligase (ADP-forming) activity
B5S57_RS01485	COG1042	CoA-binding domain protein
B5S57_RS01485	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B5S57_RS01490	COG0583	DNA-binding transcription factor activity
B5S57_RS01510	COG2433	Pfam Transposase IS66
B5S57_RS01525	COG3140	Belongs to the UPF0181 family
B5S57_RS01540	COG0745	RESPONSE REGULATOR receiver
B5S57_RS01550	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
B5S57_RS01555	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
B5S57_RS01570	COG3706	GGDEF domain
B5S57_RS01575	COG1278	Cold shock
B5S57_RS01585	COG0840	transmembrane signaling receptor activity
B5S57_RS01600	COG2501	S4 domain
B5S57_RS01605	COG0625	glutathione transferase activity
B5S57_RS01620	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B5S57_RS01625	COG0488	(ABC) transporter
B5S57_RS01640	COG2050	protein possibly involved in aromatic compounds catabolism
B5S57_RS01650	COG2824	Alkylphosphonate utilization operon protein PhnA
B5S57_RS01675	COG2433	Pfam Transposase IS66
B5S57_RS01705	COG0602	queuosine metabolic process
B5S57_RS01710	COG1328	CTP reductase activity
B5S57_RS01715	COG1328	CTP reductase activity
B5S57_RS01720	COG3706	GGDEF domain
B5S57_RS01760	COG0446	pyridine nucleotide-disulphide oxidoreductase
B5S57_RS01765	COG3550	peptidyl-serine autophosphorylation
B5S57_RS01775	COG0697	spore germination
B5S57_RS01785	COG3344	reverse transcriptase
B5S57_RS01790	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B5S57_RS01895	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B5S57_RS01900	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B5S57_RS02025	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B5S57_RS02040	COG5001	Diguanylate cyclase
B5S57_RS02040	COG3300	MHYT domain
B5S57_RS02045	COG4191	Histidine kinase
B5S57_RS02050	COG3852	Histidine kinase
B5S57_RS02060	COG3437	response regulator, receiver
B5S57_RS02075	COG3706	GGDEF domain
B5S57_RS02075	COG4251	negative regulation of phosphorylation
B5S57_RS02075	COG2203	Gaf domain
B5S57_RS02075	COG5001	Diguanylate cyclase
B5S57_RS02085	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
B5S57_RS02090	COG4149	molybdate abc transporter
B5S57_RS02095	COG0725	ABC transporter, periplasmic molybdate-binding protein
B5S57_RS02100	COG1492	cobalamin metabolic process
B5S57_RS02105	COG3111	PFAM Bacterial OB fold (BOF) protein
B5S57_RS02120	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
B5S57_RS02130	COG2207	Transcriptional regulator
B5S57_RS02160	COG2271	Major facilitator Superfamily
B5S57_RS02165	COG0469	pyruvate kinase activity
B5S57_RS02170	COG2205	protein histidine kinase activity
B5S57_RS02170	COG2198	Histidine kinase
B5S57_RS02170	COG0784	Response regulator, receiver
B5S57_RS02175	COG1879	ABC-type sugar transport system periplasmic component
B5S57_RS02180	COG1803	Methylglyoxal synthase
B5S57_RS02185	COG0210	DNA helicase
B5S57_RS02190	COG1289	transmembrane transporter activity
B5S57_RS02220	COG5002	protein histidine kinase activity
B5S57_RS02220	COG0784	Response regulator, receiver
B5S57_RS02235	COG2827	Endonuclease containing a URI domain
B5S57_RS02240	COG3132	Protein of unknown function, DUF480
B5S57_RS02260	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B5S57_RS02265	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B5S57_RS02270	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
B5S57_RS02275	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
B5S57_RS02280	COG0247	lactate metabolic process
B5S57_RS02285	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B5S57_RS02290	COG3118	belongs to the thioredoxin family
B5S57_RS02310	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B5S57_RS02330	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B5S57_RS02360	COG4176	ABC-type proline glycine betaine transport system permease component
B5S57_RS02365	COG0517	IMP dehydrogenase activity
B5S57_RS02365	COG4175	Glycine betaine
B5S57_RS02380	COG2425	protein containing a von Willebrand factor type A (vWA) domain
B5S57_RS02395	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
B5S57_RS02405	COG0513	Belongs to the DEAD box helicase family
B5S57_RS02410	COG0814	amino acid
B5S57_RS02420	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B5S57_RS02425	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
B5S57_RS02435	COG1984	allophanate hydrolase subunit 2
B5S57_RS02445	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
B5S57_RS02450	COG4181	ATPase activity
B5S57_RS02460	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B5S57_RS02465	COG5001	Diguanylate cyclase
B5S57_RS02465	COG1716	ATPase activity
B5S57_RS02475	COG0484	heat shock protein binding
B5S57_RS02520	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B5S57_RS02525	COG5001	Diguanylate cyclase
B5S57_RS02525	COG3300	MHYT domain
B5S57_RS02545	COG0010	Belongs to the arginase family
B5S57_RS02550	COG1166	arginine decarboxylase activity
B5S57_RS02565	COG4176	ABC-type proline glycine betaine transport system permease component
B5S57_RS02570	COG2113	Glycine betaine
B5S57_RS02585	COG2239	Acts as a magnesium transporter
B5S57_RS02590	COG0527	aspartate kinase activity
B5S57_RS02595	COG0662	Cupin 2, conserved barrel domain protein
B5S57_RS02600	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
B5S57_RS02605	COG0456	acetyltransferase
B5S57_RS02615	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
B5S57_RS02620	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
B5S57_RS02655	COG0366	Alpha amylase catalytic
B5S57_RS02675	COG0714	Associated with various cellular activities
B5S57_RS02695	COG2304	oxidoreductase activity
B5S57_RS02735	COG3530	Putative quorum-sensing-regulated virulence factor
B5S57_RS02740	COG1368	sulfuric ester hydrolase activity
B5S57_RS02750	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
B5S57_RS02755	COG1063	alcohol dehydrogenase
B5S57_RS02905	COG0463	Glycosyl transferase, family 2
B5S57_RS02940	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B5S57_RS02965	COG1802	Transcriptional regulator
B5S57_RS02965	COG4626	Terminase
B5S57_RS02995	COG0582	viral genome integration into host DNA
B5S57_RS03005	COG1401	restriction endodeoxyribonuclease activity
B5S57_RS03015	COG1063	alcohol dehydrogenase
B5S57_RS03020	COG0156	8-amino-7-oxononanoate synthase activity
B5S57_RS03030	COG0346	lactoylglutathione lyase activity
B5S57_RS03045	COG2197	response regulator
B5S57_RS03050	COG3851	Histidine kinase
B5S57_RS03055	COG2271	Major facilitator Superfamily
B5S57_RS03065	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
B5S57_RS03070	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
B5S57_RS03090	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B5S57_RS03095	COG0640	Transcriptional regulator
B5S57_RS03100	COG0798	PFAM Bile acid sodium symporter
B5S57_RS03110	COG0659	secondary active sulfate transmembrane transporter activity
B5S57_RS03115	COG0589	response to stress
B5S57_RS03130	COG0516	GMP reductase activity
B5S57_RS03135	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B5S57_RS03160	COG1278	Cold shock
B5S57_RS03165	COG4681	YaeQ
B5S57_RS03175	COG3604	Transcriptional regulator
B5S57_RS03185	COG2195	Cleaves the N-terminal amino acid of tripeptides
B5S57_RS03190	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B5S57_RS03195	COG3217	Mosc domain protein beta barrel domain protein
B5S57_RS03195	COG0633	Ferredoxin
B5S57_RS03200	COG0418	dihydroorotase activity
B5S57_RS03205	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B5S57_RS03210	COG2354	Protein conserved in bacteria
B5S57_RS03215	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
B5S57_RS03285	COG5001	Diguanylate cyclase
B5S57_RS03295	COG1741	Belongs to the pirin family
B5S57_RS03305	COG3123	guanosine phosphorylase activity
B5S57_RS03315	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
B5S57_RS03325	COG0765	amino acid transport
B5S57_RS03330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B5S57_RS03335	COG0765	amino acid transport
B5S57_RS03340	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B5S57_RS03360	COG0179	Fumarylacetoacetate (FAA) hydrolase
B5S57_RS03370	COG0697	spore germination
B5S57_RS03385	COG2814	Major facilitator Superfamily
B5S57_RS03390	COG0583	DNA-binding transcription factor activity
B5S57_RS03395	COG5001	Diguanylate cyclase
B5S57_RS03400	COG0739	heme binding
B5S57_RS03410	COG0659	secondary active sulfate transmembrane transporter activity
B5S57_RS03415	COG3314	Sporulation integral membrane protein YlbJ
B5S57_RS03430	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B5S57_RS03435	COG0581	inorganic phosphate transmembrane transporter activity
B5S57_RS03440	COG0573	inorganic phosphate transmembrane transporter activity
B5S57_RS03445	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
B5S57_RS03455	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B5S57_RS03460	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B5S57_RS03480	COG3047	cAMP biosynthetic process
B5S57_RS03495	COG2271	Major facilitator Superfamily
B5S57_RS03500	COG0584	glycerophosphoryl diester phosphodiesterase
B5S57_RS03510	COG3527	Alpha-acetolactate decarboxylase
B5S57_RS03535	COG0583	DNA-binding transcription factor activity
B5S57_RS03540	COG1620	l-lactate permease
B5S57_RS03560	COG1881	PFAM PEBP family protein
B5S57_RS03565	COG3122	Protein conserved in bacteria
B5S57_RS03595	COG1609	Transcriptional regulator
B5S57_RS03600	COG1472	Belongs to the glycosyl hydrolase 3 family
B5S57_RS03605	COG3842	ATPase activity
B5S57_RS03610	COG0395	ABC-type sugar transport system, permease component
B5S57_RS03625	COG1609	Transcriptional regulator
B5S57_RS03630	COG4580	involved in the transport of maltose and maltodextrins
B5S57_RS03650	COG2211	Major facilitator Superfamily
B5S57_RS03660	COG1067	ATP-dependent peptidase activity
B5S57_RS03670	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
B5S57_RS03675	COG0363	glucosamine-6-phosphate deaminase activity
B5S57_RS03685	COG0583	DNA-binding transcription factor activity
B5S57_RS03710	COG1609	Transcriptional regulator
B5S57_RS03715	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B5S57_RS03720	COG1879	ABC-type sugar transport system periplasmic component
B5S57_RS03725	COG1172	Belongs to the binding-protein-dependent transport system permease family
B5S57_RS03730	COG1129	ABC transporter
B5S57_RS03735	COG1869	D-ribose catabolic process
B5S57_RS03750	COG3501	Rhs element vgr protein
B5S57_RS03750	COG3409	Peptidoglycan-binding domain 1 protein
B5S57_RS03760	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
B5S57_RS03765	COG1640	4-alpha-glucanotransferase
B5S57_RS03770	COG0058	SHG alpha-glucan phosphorylase activity
B5S57_RS03775	COG2909	trisaccharide binding
B5S57_RS03800	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B5S57_RS03855	COG1262	PFAM Formylglycine-generating sulfatase enzyme
B5S57_RS03865	COG0259	pyridoxamine-phosphate oxidase activity
B5S57_RS03915	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
B5S57_RS03920	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
B5S57_RS03925	COG0840	transmembrane signaling receptor activity
B5S57_RS03935	COG0835	chemotaxis
B5S57_RS03955	COG0745	RESPONSE REGULATOR receiver
B5S57_RS03965	COG1444	tRNA N-acetyltransferase activity
B5S57_RS04035	COG0814	amino acid
B5S57_RS04065	COG0583	DNA-binding transcription factor activity
B5S57_RS04070	COG2910	NAD(P)H-binding
B5S57_RS04080	COG3304	Inner membrane component domain
B5S57_RS04095	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B5S57_RS04100	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
B5S57_RS04120	COG0363	glucosamine-6-phosphate deaminase activity
B5S57_RS04130	COG0739	heme binding
B5S57_RS04135	COG2213	PTS system mannitol-specific
B5S57_RS04135	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
B5S57_RS04140	COG0246	Mannitol dehydrogenase
B5S57_RS04145	COG3722	fumarate hydratase activity
B5S57_RS04155	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
B5S57_RS04160	COG1301	dicarboxylic acid transport
B5S57_RS04165	COG2259	Doxx family
B5S57_RS04190	COG1846	Transcriptional regulator
B5S57_RS04200	COG4943	cyclic-guanylate-specific phosphodiesterase activity
B5S57_RS04205	COG3046	protein related to deoxyribodipyrimidine photolyase
B5S57_RS04210	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B5S57_RS04215	COG0842	Transport permease protein
B5S57_RS04220	COG1131	(ABC) transporter
B5S57_RS04235	COG3842	ATPase activity
B5S57_RS04245	COG1175	transmembrane transport
B5S57_RS04265	COG0513	Belongs to the DEAD box helicase family
B5S57_RS04270	COG0251	oxidation-reduction process
B5S57_RS04275	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B5S57_RS04285	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
B5S57_RS04290	COG1328	CTP reductase activity
B5S57_RS04300	COG2130	NADP-dependent
B5S57_RS04305	COG1309	transcriptional regulator
B5S57_RS04320	COG0745	RESPONSE REGULATOR receiver
B5S57_RS04330	COG0564	pseudouridine synthase activity
B5S57_RS04395	COG3829	transcription factor binding
B5S57_RS04420	COG3501	Rhs element vgr protein
B5S57_RS04475	COG0471	metal ion transport
B5S57_RS04480	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
B5S57_RS04490	COG2188	Transcriptional regulator
B5S57_RS04495	COG1131	(ABC) transporter
B5S57_RS04535	COG0671	phosphoesterase, PA-phosphatase related
B5S57_RS04545	COG1132	(ABC) transporter
B5S57_RS04565	COG3623	hexulose-6-phosphate isomerase
B5S57_RS04570	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
B5S57_RS04575	COG0561	phosphatase activity
B5S57_RS04635	COG0366	Alpha amylase catalytic
B5S57_RS04645	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
B5S57_RS04655	COG1999	signal sequence binding
B5S57_RS04675	COG0786	glutamate:sodium symporter activity
B5S57_RS04700	COG1566	PFAM secretion protein HlyD family protein
B5S57_RS04725	COG0813	purine-nucleoside phosphorylase activity
B5S57_RS04730	COG3272	Protein of unknown function (DUF1722)
B5S57_RS04735	COG0789	Transcriptional regulator
B5S57_RS04740	COG0415	Belongs to the DNA photolyase family
B5S57_RS04745	COG1376	ErfK ybiS ycfS ynhG family protein
B5S57_RS04745	COG1388	LysM domain
B5S57_RS04755	COG0513	Belongs to the DEAD box helicase family
B5S57_RS04795	COG0366	Alpha amylase catalytic
B5S57_RS04800	COG4989	oxidoreductase activity
B5S57_RS04810	COG0577	efflux transmembrane transporter activity
B5S57_RS04810	COG1136	(ABC) transporter
B5S57_RS04815	COG4591	ABC-type transport system involved in lipoprotein release permease component
B5S57_RS04830	COG2972	Histidine kinase
B5S57_RS04830	COG0745	RESPONSE REGULATOR receiver
B5S57_RS04835	COG3279	Response regulator of the LytR AlgR family
B5S57_RS04840	COG5001	Diguanylate cyclase
B5S57_RS04840	COG3706	GGDEF domain
B5S57_RS04840	COG4251	negative regulation of phosphorylation
B5S57_RS04840	COG2203	Gaf domain
B5S57_RS04850	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
B5S57_RS04860	COG3437	response regulator, receiver
B5S57_RS04865	COG3437	response regulator, receiver
B5S57_RS04865	COG3850	Histidine kinase
B5S57_RS04865	COG4999	Histidine kinase
B5S57_RS04865	COG2205	protein histidine kinase activity
B5S57_RS04875	COG0531	amino acid
B5S57_RS04890	COG1151	hydroxylamine reductase activity
B5S57_RS04900	COG5002	protein histidine kinase activity
B5S57_RS04900	COG2205	protein histidine kinase activity
B5S57_RS04900	COG0784	Response regulator, receiver
B5S57_RS04915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B5S57_RS04920	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B5S57_RS04935	COG0673	inositol 2-dehydrogenase activity
B5S57_RS04940	COG1765	OsmC-like protein
B5S57_RS04945	COG0110	maltose O-acetyltransferase activity
B5S57_RS04960	COG0583	DNA-binding transcription factor activity
B5S57_RS04970	COG0583	DNA-binding transcription factor activity
B5S57_RS04975	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B5S57_RS04980	COG3186	Phenylalanine-4-hydroxylase
B5S57_RS04985	COG2154	pterin-4-alpha-carbinolamine dehydratase
B5S57_RS04990	COG0840	transmembrane signaling receptor activity
B5S57_RS04995	COG0534	Mate efflux family protein
B5S57_RS05000	COG2207	Transcriptional regulator
B5S57_RS05005	COG3437	response regulator, receiver
B5S57_RS05005	COG0784	Response regulator, receiver
B5S57_RS05010	COG4191	Histidine kinase
B5S57_RS05010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B5S57_RS05020	COG2814	Major facilitator Superfamily
B5S57_RS05030	COG0443	Heat shock 70 kDa protein
B5S57_RS05045	COG3240	lipase activity
B5S57_RS05055	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
B5S57_RS05060	COG5380	lipid catabolic process
B5S57_RS05080	COG4934	collagen metabolic process
B5S57_RS05100	COG4607	ABC-type enterochelin transport system periplasmic component
B5S57_RS05105	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B5S57_RS05110	COG4605	iron ion homeostasis
B5S57_RS05115	COG4604	ABC transporter, ATP-binding protein
B5S57_RS05120	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
B5S57_RS05125	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B5S57_RS05140	COG3344	reverse transcriptase
B5S57_RS05165	COG2433	Pfam Transposase IS66
B5S57_RS05180	COG1357	PFAM Pentapeptide repeats (8 copies)
B5S57_RS05190	COG2433	Pfam Transposase IS66
B5S57_RS05210	COG0602	queuosine metabolic process
B5S57_RS05220	COG4067	protein conserved in archaea
B5S57_RS05220	COG0189	ligase activity
B5S57_RS05235	COG4166	transmembrane transport
B5S57_RS05240	COG4174	ABC transporter (Permease)
B5S57_RS05245	COG4239	(ABC) transporter, permease
B5S57_RS05250	COG4172	Belongs to the ABC transporter superfamily
B5S57_RS05255	COG2203	Gaf domain
B5S57_RS05255	COG5001	Diguanylate cyclase
B5S57_RS05255	COG4251	negative regulation of phosphorylation
B5S57_RS05255	COG3706	GGDEF domain
B5S57_RS05265	COG3038	cytochrome b561
B5S57_RS05270	COG2353	YceI-like domain
B5S57_RS05275	COG0840	transmembrane signaling receptor activity
B5S57_RS05280	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B5S57_RS05285	COG0545	Peptidyl-prolyl cis-trans isomerase
B5S57_RS05300	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
B5S57_RS05320	COG2897	thiosulfate sulfurtransferase activity
B5S57_RS05325	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B5S57_RS05330	COG0303	'Molybdopterin
B5S57_RS05335	COG0302	gtp cyclohydrolase
B5S57_RS05340	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B5S57_RS05340	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B5S57_RS05345	COG2759	Belongs to the formate--tetrahydrofolate ligase family
B5S57_RS05350	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B5S57_RS05355	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
B5S57_RS05365	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
B5S57_RS05370	COG1011	Hydrolase
B5S57_RS05375	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B5S57_RS05380	COG2188	Transcriptional regulator
B5S57_RS05390	COG3104	oligopeptide transport
B5S57_RS05400	COG2116	formate transmembrane transporter activity
B5S57_RS05405	COG0583	DNA-binding transcription factor activity
B5S57_RS05415	COG3593	DNA synthesis involved in DNA repair
B5S57_RS05420	COG0737	Belongs to the 5'-nucleotidase family
B5S57_RS05430	COG2433	Pfam Transposase IS66
B5S57_RS05450	COG0500	methyltransferase
B5S57_RS05460	COG2433	Pfam Transposase IS66
B5S57_RS05565	COG2433	Pfam Transposase IS66
B5S57_RS05640	COG0606	chelatase, subunit chli
B5S57_RS05650	COG3978	acetolactate synthase activity
B5S57_RS05655	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B5S57_RS05670	COG0604	alcohol dehydrogenase
B5S57_RS05685	COG0425	Belongs to the sulfur carrier protein TusA family
B5S57_RS05695	COG2119	membrane
B5S57_RS05700	COG0752	glycyl-tRNA synthetase alpha subunit
B5S57_RS05710	COG3977	Valine--pyruvate aminotransferase
B5S57_RS05715	COG0071	Belongs to the small heat shock protein (HSP20) family
B5S57_RS05730	COG0187	DNA topoisomerase II activity
B5S57_RS05735	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B5S57_RS05740	COG0592	DNA-directed DNA polymerase activity
B5S57_RS05760	COG1126	abc transporter atp-binding protein
B5S57_RS05780	COG0706	membrane insertase activity
B5S57_RS05790	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
B5S57_RS05795	COG0445	tRNA wobble uridine modification
B5S57_RS05805	COG1192	Involved in chromosome partitioning
B5S57_RS05810	COG1475	DNA binding
B5S57_RS05815	COG3312	ion transport
B5S57_RS05830	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
B5S57_RS05835	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B5S57_RS05840	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
B5S57_RS05845	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
B5S57_RS05850	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
B5S57_RS05855	COG0355	proton-transporting ATP synthase activity, rotational mechanism
B5S57_RS05865	COG2814	Major facilitator Superfamily
B5S57_RS05870	COG0583	DNA-binding transcription factor activity
B5S57_RS05875	COG0183	Belongs to the thiolase family
B5S57_RS05885	COG1739	Uncharacterized protein family UPF0029
B5S57_RS05890	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B5S57_RS05895	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
B5S57_RS05945	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
B5S57_RS05950	COG0352	thiamine-phosphate diphosphorylase activity
B5S57_RS05960	COG2104	thiamine diphosphate biosynthetic process
B5S57_RS05965	COG2022	thiamine diphosphate biosynthetic process
B5S57_RS05970	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
B5S57_RS05975	COG0006	proline dipeptidase activity
B5S57_RS05975	COG0006	proline dipeptidase activity
B5S57_RS06000	COG1522	sequence-specific DNA binding
B5S57_RS06005	COG0742	ribosomal rna small subunit methyltransferase
B5S57_RS06020	COG0589	response to stress
B5S57_RS06025	COG1528	Iron-storage protein
B5S57_RS06040	COG2081	HI0933 family
B5S57_RS06050	COG1172	Belongs to the binding-protein-dependent transport system permease family
B5S57_RS06055	COG1129	ABC transporter
B5S57_RS06060	COG1879	ABC-type sugar transport system periplasmic component
B5S57_RS06065	COG1069	ribulokinase activity
B5S57_RS06075	COG2160	L-arabinose isomerase activity
B5S57_RS06095	COG1322	Protein conserved in bacteria
B5S57_RS06100	COG2226	methyltransferase
B5S57_RS06110	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
B5S57_RS06115	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B5S57_RS06120	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B5S57_RS06125	COG0805	protein transport
B5S57_RS06130	COG0084	hydrolase, TatD family'
B5S57_RS06140	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B5S57_RS06140	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B5S57_RS06160	COG3078	GTPase activator activity
B5S57_RS06180	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
B5S57_RS06185	COG2960	long-chain fatty acid transporting porin activity
B5S57_RS06190	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B5S57_RS06195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B5S57_RS06200	COG1309	transcriptional regulator
B5S57_RS06250	COG0601	transmembrane transport
B5S57_RS06255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B5S57_RS06310	COG2433	Pfam Transposase IS66
B5S57_RS06330	COG3081	Nucleoid-associated protein
B5S57_RS06350	COG2433	Pfam Transposase IS66
B5S57_RS06365	COG5290	Psort location Cytoplasmic, score
B5S57_RS06405	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B5S57_RS06410	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
B5S57_RS06415	COG0339	signal peptide processing
B5S57_RS06420	COG0210	DNA helicase
B5S57_RS06430	COG1280	lysine exporter protein (LysE YggA)
B5S57_RS06440	COG2962	Rard protein
B5S57_RS06445	COG0514	ATP-dependent DNA helicase (RecQ)
B5S57_RS06465	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
B5S57_RS06470	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B5S57_RS06470	COG1263	PTS System
B5S57_RS06475	COG1132	(ABC) transporter
B5S57_RS06480	COG4774	siderophore transport
B5S57_RS06485	COG1120	ATPase activity
B5S57_RS06510	COG0612	Peptidase, M16
B5S57_RS06535	COG2433	Pfam Transposase IS66
B5S57_RS06560	COG2433	Pfam Transposase IS66
B5S57_RS06650	COG1561	YicC-like family, N-terminal region
B5S57_RS06655	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
B5S57_RS06660	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
B5S57_RS06665	COG1560	Kdo2-lipid A biosynthetic process
B5S57_RS06670	COG1560	Kdo2-lipid A biosynthetic process
B5S57_RS06675	COG1309	transcriptional regulator
B5S57_RS06680	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B5S57_RS06685	COG2003	Belongs to the UPF0758 family
B5S57_RS06690	COG0227	Belongs to the bacterial ribosomal protein bL28 family
B5S57_RS06695	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B5S57_RS06705	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B5S57_RS06710	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
B5S57_RS06715	COG0859	PFAM glycosyl transferase family 9
B5S57_RS06720	COG0463	Glycosyl transferase, family 2
B5S57_RS06725	COG0859	PFAM glycosyl transferase family 9
B5S57_RS06730	COG3642	lipopolysaccharide core region biosynthetic process
B5S57_RS06745	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B5S57_RS06755	COG1519	Transferase
B5S57_RS06770	COG0859	PFAM glycosyl transferase family 9
B5S57_RS06775	COG3307	-O-antigen
B5S57_RS06785	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B5S57_RS06810	COG1682	transport, permease protein
B5S57_RS06855	COG0028	Belongs to the TPP enzyme family
B5S57_RS06865	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B5S57_RS06875	COG0463	Glycosyl transferase, family 2
B5S57_RS06905	COG3754	Rhamnan synthesis protein F
B5S57_RS06930	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B5S57_RS06940	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B5S57_RS06960	COG1596	polysaccharide export
B5S57_RS06965	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B5S57_RS07000	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B5S57_RS07005	COG0438	transferase activity, transferring glycosyl groups
B5S57_RS07020	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B5S57_RS07025	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
B5S57_RS07035	COG0668	transmembrane transport
B5S57_RS07040	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B5S57_RS07045	COG3068	Protein conserved in bacteria
B5S57_RS07050	COG2852	Protein conserved in bacteria
B5S57_RS07055	COG1253	flavin adenine dinucleotide binding
B5S57_RS07060	COG0776	regulation of translation
B5S57_RS07070	COG0151	Belongs to the GarS family
B5S57_RS07075	COG0138	bifunctional purine biosynthesis protein purh
B5S57_RS07080	COG0789	Transcriptional regulator
B5S57_RS07090	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
B5S57_RS07095	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B5S57_RS07100	COG2264	protein methyltransferase activity
B5S57_RS07105	COG0439	Biotin carboxylase
B5S57_RS07110	COG0511	ligase activity, forming carbon-carbon bonds
B5S57_RS07115	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
B5S57_RS07120	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B5S57_RS07135	COG2814	Major facilitator Superfamily
B5S57_RS07140	COG0784	Response regulator, receiver
B5S57_RS07140	COG2198	Histidine kinase
B5S57_RS07140	COG2205	protein histidine kinase activity
B5S57_RS07145	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B5S57_RS07165	COG4232	protein-disulfide reductase activity
B5S57_RS07170	COG1438	arginine binding
B5S57_RS07175	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
B5S57_RS07180	COG0540	Belongs to the ATCase OTCase family
B5S57_RS07190	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B5S57_RS07195	COG0549	Belongs to the carbamate kinase family
B5S57_RS07205	COG1288	antiporter activity
B5S57_RS07210	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
B5S57_RS07215	COG1027	Aspartate ammonia-lyase
B5S57_RS07220	COG3030	protein affecting phage T7 exclusion by the F plasmid
B5S57_RS07225	COG1278	Cold shock
B5S57_RS07230	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
B5S57_RS07235	COG2205	protein histidine kinase activity
B5S57_RS07240	COG0745	RESPONSE REGULATOR receiver
B5S57_RS07250	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
B5S57_RS07255	COG0205	6-phosphofructokinase activity
B5S57_RS07260	COG1494	fructose-1,6-bisphosphatase
B5S57_RS07265	COG3074	FtsZ-dependent cytokinesis
B5S57_RS07270	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
B5S57_RS07275	COG0460	homoserine dehydrogenase
B5S57_RS07275	COG0527	aspartate kinase activity
B5S57_RS07280	COG0626	cystathionine gamma-synthase activity
B5S57_RS07290	COG0281	malic enzyme
B5S57_RS07300	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
B5S57_RS07305	COG1609	Transcriptional regulator
B5S57_RS07315	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
B5S57_RS07320	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
B5S57_RS07325	COG1575	Belongs to the MenA family. Type 1 subfamily
B5S57_RS07330	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
B5S57_RS07335	COG0534	Mate efflux family protein
B5S57_RS07365	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
B5S57_RS07370	COG0459	protein refolding
B5S57_RS07385	COG1509	lysine 2,3-aminomutase activity
B5S57_RS07390	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B5S57_RS07400	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
B5S57_RS07405	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B5S57_RS07410	COG1053	succinate dehydrogenase
B5S57_RS07415	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
B5S57_RS07420	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B5S57_RS07430	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
B5S57_RS07435	COG1045	serine acetyltransferase
B5S57_RS07445	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
B5S57_RS07450	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B5S57_RS07455	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
B5S57_RS07460	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B5S57_RS07465	COG0137	argininosuccinate synthase activity
B5S57_RS07470	COG0165	Argininosuccinate lyase
B5S57_RS07470	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
B5S57_RS07480	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B5S57_RS07485	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
B5S57_RS07485	COG0678	peroxiredoxin activity
B5S57_RS07495	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
B5S57_RS07525	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
B5S57_RS07530	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
B5S57_RS07540	COG0338	D12 class N6 adenine-specific DNA methyltransferase
B5S57_RS07545	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
B5S57_RS07550	COG0546	phosphoglycolate phosphatase activity
B5S57_RS07555	COG0180	Tryptophanyl-tRNA synthetase
B5S57_RS07570	COG0583	DNA-binding transcription factor activity
B5S57_RS07580	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B5S57_RS07595	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B5S57_RS07605	COG1012	belongs to the aldehyde dehydrogenase family
B5S57_RS07615	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B5S57_RS07620	COG3954	Phosphoribulokinase
B5S57_RS07630	COG0429	hydrolase of the alpha beta-hydrolase fold
B5S57_RS07640	COG0488	(ABC) transporter
B5S57_RS07645	COG2249	NAD(P)H dehydrogenase (quinone) activity
B5S57_RS07655	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
B5S57_RS07660	COG1047	Peptidyl-prolyl cis-trans
B5S57_RS07670	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
B5S57_RS07680	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
B5S57_RS07685	COG0557	exoribonuclease II activity
B5S57_RS07690	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B5S57_RS07695	COG0051	transcription antitermination factor activity, RNA binding
B5S57_RS07700	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
B5S57_RS07705	COG0088	Forms part of the polypeptide exit tunnel
B5S57_RS07715	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
B5S57_RS07720	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
B5S57_RS07735	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
B5S57_RS07745	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
B5S57_RS07755	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
B5S57_RS07760	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
B5S57_RS07765	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B5S57_RS07770	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
B5S57_RS07775	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
B5S57_RS07785	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
B5S57_RS07790	COG1841	ribosomal large subunit assembly
B5S57_RS07795	COG0200	Binds to the 23S rRNA
B5S57_RS07800	COG0201	protein transport
B5S57_RS07805	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B5S57_RS07810	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
B5S57_RS07815	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
B5S57_RS07820	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
B5S57_RS07825	COG0202	RNA polymerase activity
B5S57_RS07830	COG0203	ribosomal protein L17
B5S57_RS07835	COG0545	Peptidyl-prolyl cis-trans isomerase
B5S57_RS07840	COG3061	Opacity-associated protein A
B5S57_RS07840	COG3266	domain, Protein
B5S57_RS07845	COG2153	protein acetylation
B5S57_RS07850	COG0513	Belongs to the DEAD box helicase family
B5S57_RS07890	COG0737	Belongs to the 5'-nucleotidase family
B5S57_RS07895	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B5S57_RS07895	COG1648	precorrin-2 dehydrogenase activity
B5S57_RS07900	COG0175	sulfate reduction
B5S57_RS07905	COG2895	sulfate adenylyltransferase (ATP) activity
B5S57_RS07910	COG0529	Catalyzes the synthesis of activated sulfate
B5S57_RS07945	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
B5S57_RS07950	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B5S57_RS07955	COG0729	surface antigen
B5S57_RS07960	COG2911	Protein conserved in bacteria
B5S57_RS07965	COG2105	PFAM AIG2 family protein
B5S57_RS07970	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
B5S57_RS07975	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
B5S57_RS07980	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B5S57_RS07985	COG0163	prenyltransferase activity
B5S57_RS07995	COG1178	ABC-type Fe3 transport system permease component
B5S57_RS08000	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
B5S57_RS08005	COG3028	Belongs to the UPF0307 family
B5S57_RS08010	COG0312	modulator of DNA gyrase
B5S57_RS08015	COG2239	Acts as a magnesium transporter
B5S57_RS08020	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B5S57_RS08025	COG1660	Displays ATPase and GTPase activities
B5S57_RS08030	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B5S57_RS08035	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
B5S57_RS08045	COG1137	ATPase activity
B5S57_RS08050	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
B5S57_RS08060	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
B5S57_RS08065	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
B5S57_RS08065	COG0517	IMP dehydrogenase activity
B5S57_RS08075	COG1127	ABC transporter
B5S57_RS08080	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
B5S57_RS08085	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
B5S57_RS08090	COG2854	intermembrane phospholipid transfer
B5S57_RS08100	COG5007	Belongs to the BolA IbaG family
B5S57_RS08105	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B5S57_RS08110	COG0204	Acyl-transferase
B5S57_RS08125	COG0251	oxidation-reduction process
B5S57_RS08130	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
B5S57_RS08145	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
B5S57_RS08155	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B5S57_RS08165	COG0564	pseudouridine synthase activity
B5S57_RS08170	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B5S57_RS08175	COG0525	valine-tRNA ligase activity
B5S57_RS08180	COG2927	DNA polymerase III (CHI subunit)
B5S57_RS08185	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B5S57_RS08190	COG0795	lipopolysaccharide-transporting ATPase activity
B5S57_RS08195	COG0795	lipopolysaccharide-transporting ATPase activity
B5S57_RS08255	COG0066	3-isopropylmalate dehydratase activity
B5S57_RS08265	COG0473	3-isopropylmalate dehydrogenase activity
B5S57_RS08285	COG0583	DNA-binding transcription factor activity
B5S57_RS08290	COG1022	Amp-dependent synthetase and ligase
B5S57_RS08295	COG0028	Belongs to the TPP enzyme family
B5S57_RS08305	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B5S57_RS08315	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
B5S57_RS08325	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
B5S57_RS08330	COG3079	Belongs to the UPF0149 family
B5S57_RS08335	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B5S57_RS08340	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B5S57_RS08360	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
B5S57_RS08370	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
B5S57_RS08375	COG1595	DNA-templated transcription, initiation
B5S57_RS08390	COG3086	response to oxidative stress
B5S57_RS08395	COG0481	GTPase activity
B5S57_RS08405	COG0571	ribonuclease III activity
B5S57_RS08410	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
B5S57_RS08415	COG1381	Involved in DNA repair and RecF pathway recombination
B5S57_RS08420	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
B5S57_RS08425	COG0736	holo-[acyl-carrier-protein] synthase activity
B5S57_RS08430	COG2205	protein histidine kinase activity
B5S57_RS08430	COG3437	response regulator, receiver
B5S57_RS08430	COG3850	Histidine kinase
B5S57_RS08430	COG4999	Histidine kinase
B5S57_RS08435	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B5S57_RS08440	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B5S57_RS08445	COG3956	TIGRFAM MazG family protein
B5S57_RS08450	COG0504	CTP synthase activity
B5S57_RS08460	COG0617	tRNA 3'-terminal CCA addition
B5S57_RS08465	COG3267	Type II secretory pathway component ExeA
B5S57_RS08465	COG3409	Peptidoglycan-binding domain 1 protein
B5S57_RS08475	COG4991	sh3 domain protein
B5S57_RS08480	COG0306	phosphate transporter
B5S57_RS08485	COG1392	Phosphate transport regulator
B5S57_RS08490	COG3025	triphosphatase activity
B5S57_RS08505	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
B5S57_RS08515	COG1538	Outer membrane efflux protein
B5S57_RS08520	COG0494	nUDIX hydrolase
B5S57_RS08525	COG3151	Protein conserved in bacteria
B5S57_RS08535	COG3150	esterase
B5S57_RS08540	COG0187	DNA topoisomerase II activity
B5S57_RS08545	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B5S57_RS08550	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B5S57_RS08555	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B5S57_RS08560	COG3105	Protein conserved in bacteria
B5S57_RS08565	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
B5S57_RS08575	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
B5S57_RS08585	COG0723	plastoquinol--plastocyanin reductase activity
B5S57_RS08590	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
B5S57_RS08595	COG2857	Cytochrome c1
B5S57_RS08600	COG0625	glutathione transferase activity
B5S57_RS08605	COG2969	positive regulation of protein catabolic process
B5S57_RS08615	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
B5S57_RS08620	COG0792	nuclease activity
B5S57_RS08625	COG3107	peptidoglycan biosynthetic process
B5S57_RS08630	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
B5S57_RS08640	COG0275	rRNA processing
B5S57_RS08645	COG3116	cell division
B5S57_RS08650	COG0768	penicillin binding
B5S57_RS08655	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B5S57_RS08660	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B5S57_RS08670	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B5S57_RS08675	COG0772	Belongs to the SEDS family
B5S57_RS08680	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B5S57_RS08685	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B5S57_RS08690	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
B5S57_RS08695	COG0849	cell division
B5S57_RS08700	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
B5S57_RS08705	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
B5S57_RS08715	COG0653	protein targeting
B5S57_RS08720	COG0494	nUDIX hydrolase
B5S57_RS08725	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
B5S57_RS08730	COG0505	Belongs to the CarA family
B5S57_RS08735	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B5S57_RS08740	COG0730	response to heat
B5S57_RS08745	COG0583	DNA-binding transcription factor activity
B5S57_RS08750	COG2860	membrane
B5S57_RS08755	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B5S57_RS08765	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
B5S57_RS08780	COG0493	'glutamate synthase
B5S57_RS08785	COG0070	glutamate synthase
B5S57_RS08785	COG0069	glutamate synthase activity
B5S57_RS08785	COG0067	glutamate synthase
B5S57_RS08795	COG0069	glutamate synthase activity
B5S57_RS08795	COG0070	glutamate synthase
B5S57_RS08795	COG0067	glutamate synthase
B5S57_RS08800	COG1242	4 iron, 4 sulfur cluster binding
B5S57_RS08805	COG2198	Histidine kinase
B5S57_RS08805	COG0784	Response regulator, receiver
B5S57_RS08805	COG5002	protein histidine kinase activity
B5S57_RS08815	COG0745	RESPONSE REGULATOR receiver
B5S57_RS08820	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
B5S57_RS08840	COG0083	homoserine kinase activity
B5S57_RS08845	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
B5S57_RS08850	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
B5S57_RS08855	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
B5S57_RS08860	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
B5S57_RS08875	COG1115	amino acid carrier protein
B5S57_RS08880	COG3022	response to hydroperoxide
B5S57_RS08885	COG0084	hydrolase, TatD family'
B5S57_RS08890	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B5S57_RS08895	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
B5S57_RS08900	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
B5S57_RS08905	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
B5S57_RS08910	COG0813	purine-nucleoside phosphorylase activity
B5S57_RS08920	COG0560	Phosphoserine phosphatase
B5S57_RS08930	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
B5S57_RS08935	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B5S57_RS08940	COG4628	conserved protein (DUF2132)
B5S57_RS08945	COG1022	Amp-dependent synthetase and ligase
B5S57_RS08950	COG3437	response regulator, receiver
B5S57_RS08950	COG0784	Response regulator, receiver
B5S57_RS08965	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B5S57_RS08970	COG1085	galactose-1-phosphate uridylyltransferase
B5S57_RS08980	COG1609	Transcriptional regulator
B5S57_RS09010	COG2171	N-acyltransferase activity
B5S57_RS09015	COG3141	response to X-ray
B5S57_RS09030	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
B5S57_RS09035	COG1074	ATP-dependent DNA helicase activity
B5S57_RS09040	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B5S57_RS09050	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B5S57_RS09050	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
B5S57_RS09060	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
B5S57_RS09065	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
B5S57_RS09070	COG2166	iron-sulfur cluster assembly
B5S57_RS09075	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B5S57_RS09085	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
B5S57_RS09100	COG1595	DNA-templated transcription, initiation
B5S57_RS09110	COG2211	Major facilitator Superfamily
B5S57_RS09130	COG0271	Belongs to the BolA IbaG family
B5S57_RS09165	COG1477	protein flavinylation
B5S57_RS09175	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B5S57_RS09190	COG0733	neurotransmitter:sodium symporter activity
B5S57_RS09200	COG0189	ligase activity
B5S57_RS09205	COG4067	protein conserved in archaea
B5S57_RS09205	COG0189	ligase activity
B5S57_RS09210	COG2195	Cleaves the N-terminal amino acid of tripeptides
B5S57_RS09215	COG2252	PERMEase
B5S57_RS09220	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
B5S57_RS09225	COG1073	alpha beta
B5S57_RS09235	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
B5S57_RS09240	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
B5S57_RS09245	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
B5S57_RS09250	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B5S57_RS09250	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B5S57_RS09270	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B5S57_RS09275	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
B5S57_RS09280	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
B5S57_RS09290	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
B5S57_RS09295	COG0024	Methionine aminopeptidase
B5S57_RS09300	COG0052	Belongs to the universal ribosomal protein uS2 family
B5S57_RS09305	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
B5S57_RS09315	COG0233	cytoplasmic translational termination
B5S57_RS09320	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B5S57_RS09325	COG0575	Belongs to the CDS family
B5S57_RS09330	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
B5S57_RS09335	COG0750	zinc metalloprotease
B5S57_RS09345	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
B5S57_RS09350	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B5S57_RS09355	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B5S57_RS09365	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B5S57_RS09375	COG0587	DNA-directed DNA polymerase activity
B5S57_RS09380	COG0825	malonyl-CoA metabolic process
B5S57_RS09385	COG0037	tRNA processing
B5S57_RS09395	COG0347	Belongs to the P(II) protein family
B5S57_RS09400	COG3021	interspecies interaction between organisms
B5S57_RS09410	COG1388	LysM domain
B5S57_RS09410	COG0741	lytic transglycosylase activity
B5S57_RS09415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B5S57_RS09420	COG2226	methyltransferase
B5S57_RS09425	COG0328	RNA-DNA hybrid ribonuclease activity
B5S57_RS09445	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
B5S57_RS09450	COG0121	glutamine amidotransferase
B5S57_RS09455	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
B5S57_RS09460	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
B5S57_RS09465	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
B5S57_RS09470	COG1187	pseudouridine synthase activity
B5S57_RS09495	COG2608	mercury ion transmembrane transporter activity
B5S57_RS09495	COG2217	Heavy metal translocating P-type atpase
B5S57_RS09540	COG2747	anti-sigma28 factor FlgM
B5S57_RS09550	COG0835	chemotaxis
B5S57_RS09550	COG0784	Response regulator, receiver
B5S57_RS09560	COG1815	bacterial-type flagellum-dependent cell motility
B5S57_RS09575	COG1749	Flagellar hook protein flgE
B5S57_RS09580	COG4787	bacterial-type flagellum-dependent cell motility
B5S57_RS09590	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
B5S57_RS09595	COG1706	bacterial-type flagellum-dependent cell motility
B5S57_RS09600	COG1705	Flagellar rod assembly protein muramidase FlgJ
B5S57_RS09600	COG3951	Flagellar rod assembly protein muramidase FlgJ
B5S57_RS09610	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
B5S57_RS09705	COG0193	aminoacyl-tRNA hydrolase activity
B5S57_RS09710	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B5S57_RS09720	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
B5S57_RS09725	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
B5S57_RS09730	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
B5S57_RS09735	COG2890	protein-(glutamine-N5) methyltransferase activity
B5S57_RS09740	COG3094	Invasion gene expression up-regulator, SirB
B5S57_RS09745	COG2912	Transglutaminase-like superfamily
B5S57_RS09750	COG2877	3-deoxy-8-phosphooctulonate synthase activity
B5S57_RS09760	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
B5S57_RS09765	COG2233	PERMEase
B5S57_RS09785	COG1393	Belongs to the ArsC family
B5S57_RS09790	COG4783	chaperone-mediated protein folding
B5S57_RS09810	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B5S57_RS09840	COG0210	DNA helicase
B5S57_RS09875	COG2801	Transposase and inactivated derivatives
B5S57_RS09885	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B5S57_RS09925	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
B5S57_RS09945	COG1393	Belongs to the ArsC family
B5S57_RS09970	COG2837	iron assimilation
B5S57_RS09995	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
B5S57_RS10005	COG1516	flagellar protein fliS
B5S57_RS10025	COG1677	Flagellar hook-basal body complex protein FliE
B5S57_RS10035	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B5S57_RS10085	COG1987	bacterial-type flagellum assembly
B5S57_RS10090	COG1684	flagellar biosynthetic protein fliR
B5S57_RS10100	COG2840	Smr protein MutS2
B5S57_RS10105	COG2890	protein-(glutamine-N5) methyltransferase activity
B5S57_RS10110	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
B5S57_RS10115	COG2860	membrane
B5S57_RS10120	COG3101	peptidyl-lysine hydroxylation
B5S57_RS10130	COG0431	NADPH-dependent FMN reductase
B5S57_RS10135	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B5S57_RS10135	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
B5S57_RS10140	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B5S57_RS10145	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B5S57_RS10150	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
B5S57_RS10155	COG0735	belongs to the Fur family
B5S57_RS10165	COG0583	DNA-binding transcription factor activity
B5S57_RS10175	COG1346	cytolysis
B5S57_RS10190	COG0596	Alpha beta hydrolase
B5S57_RS10195	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
B5S57_RS10200	COG0033	Phosphoglucomutase
B5S57_RS10210	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
B5S57_RS10225	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
B5S57_RS10240	COG0567	Dehydrogenase, E1 component
B5S57_RS10245	COG0508	dehydrogenase complex catalyzes the overall conversion of
B5S57_RS10260	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B5S57_RS10265	COG1121	(ABC) transporter
B5S57_RS10270	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
B5S57_RS10275	COG4977	sequence-specific DNA binding
B5S57_RS10280	COG1918	ferrous iron import across plasma membrane
B5S57_RS10305	COG3102	Protein conserved in bacteria
B5S57_RS10310	COG1025	Belongs to the peptidase M16 family
B5S57_RS10315	COG2062	phosphohistidine phosphatase, SixA
B5S57_RS10320	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
B5S57_RS10345	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
B5S57_RS10350	COG2198	Histidine kinase
B5S57_RS10350	COG0784	Response regulator, receiver
B5S57_RS10350	COG0643	Histidine kinase
B5S57_RS10355	COG2201	protein-glutamate methylesterase activity
B5S57_RS10360	COG1192	Involved in chromosome partitioning
B5S57_RS10370	COG0835	chemotaxis
B5S57_RS10380	COG4133	protoheme IX ABC transporter activity
B5S57_RS10385	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B5S57_RS10390	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B5S57_RS10400	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
B5S57_RS10405	COG1138	Cytochrome C-type biogenesis protein
B5S57_RS10410	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B5S57_RS10425	COG2853	Lipoprotein
B5S57_RS10445	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
B5S57_RS10450	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B5S57_RS10465	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
B5S57_RS10470	COG0243	molybdopterin cofactor binding
B5S57_RS10480	COG3083	sulfuric ester hydrolase activity
B5S57_RS10485	COG3082	Protein of unknown function (DUF1414)
B5S57_RS10500	COG1757	Na H antiporter
B5S57_RS10505	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
B5S57_RS10510	COG2095	MarC family integral membrane protein
B5S57_RS10515	COG1012	belongs to the aldehyde dehydrogenase family
B5S57_RS10515	COG1454	alcohol dehydrogenase
B5S57_RS10525	COG1530	ribonuclease E activity
B5S57_RS10530	COG0564	pseudouridine synthase activity
B5S57_RS10535	COG0424	maF-like protein
B5S57_RS10540	COG1399	metal-binding, possibly nucleic acid-binding protein
B5S57_RS10555	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B5S57_RS10580	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B5S57_RS10585	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
B5S57_RS10590	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B5S57_RS10595	COG0470	DNA polymerase III
B5S57_RS10600	COG0084	hydrolase, TatD family'
B5S57_RS10605	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B5S57_RS10605	COG1263	PTS System
B5S57_RS10615	COG0733	neurotransmitter:sodium symporter activity
B5S57_RS10630	COG4667	esterase of the alpha-beta hydrolase superfamily
B5S57_RS10640	COG1940	carbohydrate kinase activity
B5S57_RS10645	COG0784	Response regulator, receiver
B5S57_RS10645	COG0835	chemotaxis
B5S57_RS10650	COG1028	Short-chain dehydrogenase reductase Sdr
B5S57_RS10655	COG0616	signal peptide processing
B5S57_RS10670	COG0232	Belongs to the dGTPase family. Type 2 subfamily
B5S57_RS10675	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
B5S57_RS10680	COG0436	Aminotransferase
B5S57_RS10690	COG1169	isochorismate synthase
B5S57_RS10695	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
B5S57_RS10705	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
B5S57_RS10755	COG1522	sequence-specific DNA binding
B5S57_RS10760	COG1946	Acyl-CoA thioesterase
B5S57_RS10765	COG3126	Type III secretion system lipoprotein chaperone (YscW)
B5S57_RS10780	COG3706	GGDEF domain
B5S57_RS10805	COG1022	Amp-dependent synthetase and ligase
B5S57_RS10815	COG4221	oxidoreductase activity
B5S57_RS10825	COG0745	RESPONSE REGULATOR receiver
B5S57_RS10830	COG0642	Histidine kinase
B5S57_RS10835	COG2194	sulfuric ester hydrolase activity
B5S57_RS10850	COG2985	domain, Protein
B5S57_RS10860	COG5002	protein histidine kinase activity
B5S57_RS10860	COG3850	Histidine kinase
B5S57_RS10875	COG1609	Transcriptional regulator
B5S57_RS10880	COG0129	dihydroxy-acid dehydratase activity
B5S57_RS10885	COG3265	gluconokinase activity
B5S57_RS10890	COG2610	gluconate transmembrane transporter activity
B5S57_RS10895	COG0800	Aldolase
B5S57_RS10920	COG1028	Short-chain dehydrogenase reductase Sdr
B5S57_RS10925	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B5S57_RS10930	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B5S57_RS10960	COG1216	Glycosyl transferase, family 2
B5S57_RS10980	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B5S57_RS10985	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B5S57_RS11020	COG5002	protein histidine kinase activity
B5S57_RS11020	COG0784	Response regulator, receiver
B5S57_RS11035	COG0601	transmembrane transport
B5S57_RS11040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B5S57_RS11045	COG0444	Belongs to the ABC transporter superfamily
B5S57_RS11055	COG0435	Glutathione S-transferase
B5S57_RS11060	COG0857	belongs to the CobB CobQ family
B5S57_RS11060	COG0280	phosphate acetyltransferase
B5S57_RS11065	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
B5S57_RS11070	COG3092	negative regulation of chromosome organization
B5S57_RS11080	COG4120	Belongs to the binding-protein-dependent transport system permease family
B5S57_RS11090	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B5S57_RS11095	COG0653	protein targeting
B5S57_RS11100	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
B5S57_RS11105	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
B5S57_RS11115	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B5S57_RS11120	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
B5S57_RS11125	COG0156	8-amino-7-oxononanoate synthase activity
B5S57_RS11130	COG2226	methyltransferase
B5S57_RS11135	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
B5S57_RS11145	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
B5S57_RS11150	COG2186	Transcriptional regulator
B5S57_RS11165	COG0537	adenosine 5'-monophosphoramidase activity
B5S57_RS11190	COG3150	esterase
B5S57_RS11195	COG1252	NADH dehydrogenase
B5S57_RS11210	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
B5S57_RS11220	COG4591	ABC-type transport system involved in lipoprotein release permease component
B5S57_RS11225	COG1136	(ABC) transporter
B5S57_RS11230	COG4591	ABC-type transport system involved in lipoprotein release permease component
B5S57_RS11240	COG0658	competence protein
B5S57_RS11240	COG2333	competence protein COMEC
B5S57_RS11245	COG1132	(ABC) transporter
B5S57_RS11260	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
B5S57_RS11270	COG2719	SpoVR family
B5S57_RS11275	COG2718	Belongs to the UPF0229 family
B5S57_RS11280	COG2766	serine protein kinase
B5S57_RS11285	COG3013	Belongs to the UPF0304 family
B5S57_RS11295	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
B5S57_RS11310	COG1882	Formate acetyltransferase
B5S57_RS11340	COG4160	amino acid transport
B5S57_RS11345	COG0708	Exodeoxyribonuclease III
B5S57_RS11350	COG0840	transmembrane signaling receptor activity
B5S57_RS11360	COG3923	Primosomal replication protein n
B5S57_RS11370	COG1199	ATP-dependent helicase activity
B5S57_RS11380	COG3012	SEC-C Motif Domain Protein
B5S57_RS11385	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
B5S57_RS11390	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B5S57_RS11395	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
B5S57_RS11400	COG0215	cysteine-tRNA ligase activity
B5S57_RS11405	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
B5S57_RS11410	COG0632	four-way junction helicase activity
B5S57_RS11415	COG2255	four-way junction helicase activity
B5S57_RS11420	COG1271	oxidase subunit
B5S57_RS11425	COG1294	oxidase, subunit
B5S57_RS11430	COG4890	Cyd operon protein YbgT
B5S57_RS11435	COG3790	cyd operon protein YbgE
B5S57_RS11440	COG0824	Thioesterase
B5S57_RS11445	COG0811	peptide transport
B5S57_RS11460	COG0823	Involved in the tonB-independent uptake of proteins
B5S57_RS11465	COG2885	chlorophyll binding
B5S57_RS11470	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
B5S57_RS11475	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
B5S57_RS11480	COG2433	Pfam Transposase IS66
B5S57_RS11500	COG5002	protein histidine kinase activity
B5S57_RS11500	COG0784	Response regulator, receiver
B5S57_RS11515	COG0582	viral genome integration into host DNA
B5S57_RS11610	COG2404	hydrolase activity, acting on ester bonds
B5S57_RS11640	COG3081	Nucleoid-associated protein
B5S57_RS11730	COG1403	HNH endonuclease
B5S57_RS11795	COG1802	Transcriptional regulator
B5S57_RS11795	COG4626	Terminase
B5S57_RS11810	COG0740	serine-type endopeptidase activity
B5S57_RS11940	COG5001	Diguanylate cyclase
B5S57_RS11940	COG3300	MHYT domain
B5S57_RS11965	COG1960	acyl-CoA dehydrogenase activity
B5S57_RS11970	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B5S57_RS12000	COG0247	lactate metabolic process
B5S57_RS12000	COG0277	FAD linked oxidase domain protein
B5S57_RS12015	COG2986	histidine ammonia-lyase
B5S57_RS12025	COG0010	Belongs to the arginase family
B5S57_RS12030	COG1228	amidohydrolase
B5S57_RS12040	COG3097	Belongs to the UPF0267 family
B5S57_RS12045	COG3099	Belongs to the UPF0263 family
B5S57_RS12050	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B5S57_RS12060	COG0417	DNA replication proofreading
B5S57_RS12065	COG2197	response regulator
B5S57_RS12070	COG0322	excinuclease ABC activity
B5S57_RS12110	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
B5S57_RS12115	COG0072	phenylalanine-tRNA ligase activity
B5S57_RS12115	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B5S57_RS12120	COG0776	regulation of translation
B5S57_RS12130	COG0500	methyltransferase
B5S57_RS12145	COG5001	Diguanylate cyclase
B5S57_RS12155	COG1346	cytolysis
B5S57_RS12160	COG1380	Effector of murein hydrolase LrgA
B5S57_RS12165	COG2925	Exonuclease
B5S57_RS12170	COG1823	symporter activity
B5S57_RS12175	COG0702	epimerase
B5S57_RS12220	COG0210	DNA helicase
B5S57_RS12255	COG2801	Transposase and inactivated derivatives
B5S57_RS12265	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B5S57_RS12305	COG2994	toxin metabolic process
B5S57_RS12310	COG3064	Membrane
B5S57_RS12310	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
B5S57_RS12310	COG1073	alpha beta
B5S57_RS12315	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
B5S57_RS12320	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
B5S57_RS12335	COG2988	succinylglutamate desuccinylase activity
B5S57_RS12340	COG4139	cobalamin transport
B5S57_RS12345	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
B5S57_RS12365	COG0583	DNA-binding transcription factor activity
B5S57_RS12375	COG1451	nucleotide metabolic process
B5S57_RS12390	COG3063	Type IV pilus biogenesis stability protein PilW
B5S57_RS12415	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B5S57_RS12430	COG3290	protein histidine kinase activity
B5S57_RS12435	COG4565	transcriptional regulatory protein
B5S57_RS12445	COG0835	chemotaxis
B5S57_RS12445	COG0784	Response regulator, receiver
B5S57_RS12485	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
B5S57_RS12560	COG1181	Belongs to the D-alanine--D-alanine ligase family
B5S57_RS12580	COG1716	ATPase activity
B5S57_RS12605	COG0515	serine threonine protein kinase
B5S57_RS12605	COG3064	Membrane
B5S57_RS12605	COG4991	sh3 domain protein
B5S57_RS12655	COG2433	Pfam Transposase IS66
B5S57_RS12675	COG0251	oxidation-reduction process
B5S57_RS12685	COG1294	oxidase, subunit
B5S57_RS12705	COG3220	belongs to the UPF0276 family
B5S57_RS12730	COG0840	transmembrane signaling receptor activity
B5S57_RS12740	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B5S57_RS12745	COG2200	EAL domain
B5S57_RS12750	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B5S57_RS12755	COG1263	PTS System
B5S57_RS12755	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B5S57_RS12765	COG1621	beta-fructofuranosidase activity
B5S57_RS12770	COG0840	transmembrane signaling receptor activity
B5S57_RS12780	COG1054	Belongs to the UPF0176 family
B5S57_RS12785	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
B5S57_RS12790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B5S57_RS12800	COG0848	biopolymer transport protein
B5S57_RS12805	COG0811	peptide transport
B5S57_RS12810	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
B5S57_RS12815	COG3721	Heme iron utilization protein
B5S57_RS12820	COG0748	coenzyme F420 binding
B5S57_RS12825	COG4771	TonB-dependent receptor
B5S57_RS12825	COG1629	transport
B5S57_RS12830	COG1940	carbohydrate kinase activity
B5S57_RS12860	COG2989	Protein conserved in bacteria
B5S57_RS12865	COG3108	Peptidase M15
B5S57_RS12870	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B5S57_RS12885	COG1846	Transcriptional regulator
B5S57_RS12890	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B5S57_RS12905	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
B5S57_RS12910	COG1448	Aminotransferase
B5S57_RS12915	COG2770	Histidine kinase
B5S57_RS12915	COG3437	response regulator, receiver
B5S57_RS12920	COG0840	transmembrane signaling receptor activity
B5S57_RS12925	COG0745	RESPONSE REGULATOR receiver
B5S57_RS12935	COG0643	Histidine kinase
B5S57_RS12935	COG2198	Histidine kinase
B5S57_RS12945	COG0835	chemotaxis
B5S57_RS12950	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
B5S57_RS12955	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
B5S57_RS12960	COG2201	protein-glutamate methylesterase activity
B5S57_RS12970	COG0017	Asparaginyl-tRNA synthetase
B5S57_RS12975	COG0840	transmembrane signaling receptor activity
B5S57_RS12980	COG0720	synthase
B5S57_RS12985	COG2356	endonuclease I
B5S57_RS12995	COG1760	l-serine dehydratase
B5S57_RS13000	COG0814	amino acid
B5S57_RS13005	COG0494	nUDIX hydrolase
B5S57_RS13010	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B5S57_RS13025	COG3106	COG3106 Predicted ATPase
B5S57_RS13030	COG3768	UPF0283 membrane protein
B5S57_RS13040	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B5S57_RS13060	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B5S57_RS13075	COG3344	reverse transcriptase
B5S57_RS13085	COG4191	Histidine kinase
B5S57_RS13085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B5S57_RS13100	COG1278	Cold shock
B5S57_RS13105	COG3005	denitrification pathway
B5S57_RS13110	COG0243	molybdopterin cofactor binding
B5S57_RS13115	COG0513	Belongs to the DEAD box helicase family
B5S57_RS13120	COG2723	6-phospho-beta-galactosidase activity
B5S57_RS13125	COG1609	Transcriptional regulator
B5S57_RS13195	COG1643	Atp-dependent helicase
B5S57_RS13205	COG0583	DNA-binding transcription factor activity
B5S57_RS13210	COG0477	Major facilitator Superfamily
B5S57_RS13225	COG0673	inositol 2-dehydrogenase activity
B5S57_RS13230	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B5S57_RS13235	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
B5S57_RS13235	COG0517	IMP dehydrogenase activity
B5S57_RS13240	COG2176	DNA-directed DNA polymerase activity
B5S57_RS13250	COG3718	enzyme involved in inositol metabolism
B5S57_RS13255	COG3962	Belongs to the TPP enzyme family
B5S57_RS13260	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B5S57_RS13285	COG0673	inositol 2-dehydrogenase activity
B5S57_RS13290	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
B5S57_RS13330	COG1204	response to ionizing radiation
B5S57_RS13350	COG2433	Pfam Transposase IS66
B5S57_RS13360	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
B5S57_RS13365	COG1280	lysine exporter protein (LysE YggA)
B5S57_RS13370	COG1115	amino acid carrier protein
B5S57_RS13380	COG2195	Cleaves the N-terminal amino acid of tripeptides
B5S57_RS13390	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
B5S57_RS13400	COG0625	glutathione transferase activity
B5S57_RS13430	COG0811	peptide transport
B5S57_RS13435	COG0811	peptide transport
B5S57_RS13440	COG0848	biopolymer transport protein
B5S57_RS13455	COG4667	esterase of the alpha-beta hydrolase superfamily
B5S57_RS13460	COG1793	dna ligase
B5S57_RS13475	COG3001	Fructosamine kinase
B5S57_RS13485	COG0791	NLP P60 protein
B5S57_RS13490	COG0840	transmembrane signaling receptor activity
B5S57_RS13500	COG3148	PFAM DTW domain containing protein
B5S57_RS13505	COG1940	carbohydrate kinase activity
B5S57_RS13515	COG1763	Mo-molybdopterin cofactor biosynthetic process
B5S57_RS13520	COG0746	molybdenum cofactor guanylyltransferase activity
B5S57_RS13525	COG3842	ATPase activity
B5S57_RS13535	COG1840	ABC-type Fe3 transport system, periplasmic component
B5S57_RS13540	COG2271	Major facilitator Superfamily
B5S57_RS13550	COG2197	response regulator
B5S57_RS13555	COG0488	(ABC) transporter
B5S57_RS13560	COG0004	ammonium transporteR
B5S57_RS13565	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
B5S57_RS13575	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
B5S57_RS13580	COG1177	transmembrane transport
B5S57_RS13585	COG1176	ABC-type spermidine putrescine transport system, permease component I
B5S57_RS13590	COG3842	ATPase activity
B5S57_RS13615	COG0589	response to stress
B5S57_RS13620	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B5S57_RS13635	COG2217	Heavy metal translocating P-type atpase
B5S57_RS13645	COG2010	Cytochrome c
B5S57_RS13660	COG3278	Belongs to the heme-copper respiratory oxidase family
B5S57_RS13690	COG3120	sequence-specific DNA binding
B5S57_RS13695	COG1067	ATP-dependent peptidase activity
B5S57_RS13700	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B5S57_RS13715	COG0488	(ABC) transporter
B5S57_RS13725	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
B5S57_RS13725	COG0116	Belongs to the methyltransferase superfamily
B5S57_RS13735	COG0167	dihydroorotate dehydrogenase activity
B5S57_RS13740	COG2902	Dehydrogenase
B5S57_RS13750	COG0308	aminopeptidase N
B5S57_RS13765	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
B5S57_RS13770	COG1956	GAF domain-containing protein
B5S57_RS13775	COG1132	(ABC) transporter
B5S57_RS13780	COG2995	paraquat-inducible protein a
B5S57_RS13785	COG3008	intermembrane lipid transfer
B5S57_RS13795	COG2996	Protein conserved in bacteria
B5S57_RS13815	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
B5S57_RS13820	COG1666	GTP binding
B5S57_RS13830	COG1648	precorrin-2 dehydrogenase activity
B5S57_RS13830	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B5S57_RS13835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B5S57_RS13840	COG4597	amino acid ABC transporter
B5S57_RS13845	COG0765	amino acid transport
B5S57_RS13850	COG1126	abc transporter atp-binding protein
B5S57_RS13855	COG0670	Belongs to the BI1 family
B5S57_RS13860	COG2920	part of a sulfur-relay system
B5S57_RS13865	COG1254	Belongs to the acylphosphatase family
B5S57_RS13910	COG0602	queuosine metabolic process
B5S57_RS13915	COG0561	phosphatase activity
B5S57_RS13935	COG2828	Protein conserved in bacteria
B5S57_RS13940	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
B5S57_RS13945	COG0372	Belongs to the citrate synthase family
B5S57_RS13950	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
B5S57_RS13980	COG0745	RESPONSE REGULATOR receiver
B5S57_RS13985	COG5002	protein histidine kinase activity
B5S57_RS13990	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
B5S57_RS13995	COG1902	pentaerythritol trinitrate reductase activity
B5S57_RS14010	COG1129	ABC transporter
B5S57_RS14030	COG1342	Belongs to the UPF0251 family
B5S57_RS14040	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B5S57_RS14050	COG2207	Transcriptional regulator
B5S57_RS14055	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B5S57_RS14055	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B5S57_RS14055	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B5S57_RS14075	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
B5S57_RS14085	COG3051	citrate lyase alpha subunit
B5S57_RS14090	COG2301	Belongs to the HpcH HpaI aldolase family
B5S57_RS14100	COG4565	transcriptional regulatory protein
B5S57_RS14110	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
B5S57_RS14115	COG5016	pyruvate
B5S57_RS14115	COG0511	ligase activity, forming carbon-carbon bonds
B5S57_RS14130	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
B5S57_RS14150	COG0840	transmembrane signaling receptor activity
B5S57_RS14160	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B5S57_RS14165	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B5S57_RS14170	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B5S57_RS14200	COG0840	transmembrane signaling receptor activity
B5S57_RS14225	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
B5S57_RS14240	COG4181	ATPase activity
B5S57_RS14245	COG0534	Mate efflux family protein
B5S57_RS14250	COG0702	epimerase
B5S57_RS14260	COG2814	Major facilitator Superfamily
B5S57_RS14265	COG1187	pseudouridine synthase activity
B5S57_RS14270	COG1061	Type III restriction enzyme res subunit
B5S57_RS14285	COG2205	protein histidine kinase activity
B5S57_RS14290	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
B5S57_RS14305	COG0513	Belongs to the DEAD box helicase family
B5S57_RS14335	COG3313	Fe-S protein
B5S57_RS14345	COG4134	Bacterial extracellular solute-binding protein
B5S57_RS14350	COG4135	transport system, permease component
B5S57_RS14355	COG4136	ATPase activity
B5S57_RS14360	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B5S57_RS14375	COG0564	pseudouridine synthase activity
B5S57_RS14380	COG0733	neurotransmitter:sodium symporter activity
B5S57_RS14390	COG0626	cystathionine gamma-synthase activity
B5S57_RS14395	COG0519	Catalyzes the synthesis of GMP from XMP
B5S57_RS14410	COG1842	Phage shock protein A
B5S57_RS14415	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
B5S57_RS14430	COG4171	peptide transport system, permease
B5S57_RS14440	COG4172	Belongs to the ABC transporter superfamily
B5S57_RS14455	COG1227	inorganic diphosphatase activity
B5S57_RS14465	COG0243	molybdopterin cofactor binding
B5S57_RS14470	COG3005	denitrification pathway
B5S57_RS14475	COG4459	periplasmic nitrate reductase
B5S57_RS14480	COG2116	formate transmembrane transporter activity
B5S57_RS14505	COG1434	Gram-negative-bacterium-type cell wall biogenesis
B5S57_RS14510	COG1435	thymidine kinase activity
B5S57_RS14515	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
B5S57_RS14520	COG1801	Protein of unknown function DUF72
B5S57_RS14530	COG4106	trans-aconitate 2-methyltransferase activity
B5S57_RS14535	COG0500	methyltransferase
B5S57_RS14540	COG0189	ligase activity
B5S57_RS14540	COG4067	protein conserved in archaea
B5S57_RS14555	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
B5S57_RS14560	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
B5S57_RS14570	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B5S57_RS14575	COG1434	Gram-negative-bacterium-type cell wall biogenesis
B5S57_RS14580	COG0745	RESPONSE REGULATOR receiver
B5S57_RS14590	COG1609	Transcriptional regulator
B5S57_RS14595	COG3070	regulator of competence-specific genes
B5S57_RS14615	COG0297	glycogen (starch) synthase activity
B5S57_RS14620	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
B5S57_RS14625	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B5S57_RS14640	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
B5S57_RS14645	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
B5S57_RS14650	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
B5S57_RS14655	COG0542	response to heat
B5S57_RS14660	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
B5S57_RS14665	COG1278	Cold shock
B5S57_RS14675	COG1187	pseudouridine synthase activity
B5S57_RS14680	COG0140	phosphoribosyl-ATP diphosphatase activity
B5S57_RS14680	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
B5S57_RS14685	COG0107	imidazoleglycerol-phosphate synthase activity
B5S57_RS14690	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
B5S57_RS14695	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
B5S57_RS14700	COG0131	Imidazoleglycerol-phosphate dehydratase
B5S57_RS14700	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
B5S57_RS14705	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B5S57_RS14710	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
B5S57_RS14715	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
B5S57_RS14720	COG1757	Na H antiporter
B5S57_RS14725	COG2916	Histone family protein nucleoid-structuring protein H-NS
B5S57_RS14730	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B5S57_RS14740	COG0482	sulfurtransferase activity
B5S57_RS14745	COG2915	High frequency lysogenization protein hflD homolog
B5S57_RS14750	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
B5S57_RS14755	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
B5S57_RS14765	COG4191	Histidine kinase
B5S57_RS14765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B5S57_RS14780	COG3070	regulator of competence-specific genes
B5S57_RS14790	COG2431	L-lysine efflux transmembrane transporter activity
B5S57_RS14800	COG0076	glutamate decarboxylase activity
B5S57_RS14805	COG1737	Transcriptional regulator
B5S57_RS14815	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
B5S57_RS14820	COG3273	potassium ion transport
B5S57_RS14820	COG2985	domain, Protein
B5S57_RS14825	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
B5S57_RS14835	COG0281	malic enzyme
B5S57_RS14845	COG2949	membrane
B5S57_RS14865	COG0492	ferredoxin-NADP+ reductase activity
B5S57_RS14870	COG4988	ABC transporter
B5S57_RS14875	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
B5S57_RS14890	COG1595	DNA-templated transcription, initiation
B5S57_RS14905	COG1187	pseudouridine synthase activity
B5S57_RS14910	COG0009	L-threonylcarbamoyladenylate synthase
B5S57_RS14915	COG0613	PHP domain protein
B5S57_RS14925	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B5S57_RS14930	COG0512	Glutamine amidotransferase of anthranilate synthase
B5S57_RS14935	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B5S57_RS14940	COG0135	phosphoribosylanthranilate isomerase activity
B5S57_RS14940	COG0134	indole-3-glycerol-phosphate synthase activity
B5S57_RS14945	COG0133	tryptophan synthase activity
B5S57_RS14950	COG0159	tryptophan synthase activity
B5S57_RS14980	COG2350	Protein conserved in bacteria
B5S57_RS14990	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
B5S57_RS14995	COG0583	DNA-binding transcription factor activity
B5S57_RS15010	COG2199	diguanylate cyclase activity
B5S57_RS15010	COG2200	EAL domain
B5S57_RS15010	COG2203	Gaf domain
B5S57_RS15020	COG1032	radical SAM domain protein
B5S57_RS15030	COG2268	Band 7 protein
B5S57_RS15040	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B5S57_RS15055	COG0300	oxidoreductase activity
B5S57_RS15065	COG0501	Belongs to the peptidase M48B family
B5S57_RS15075	COG1674	ftsk spoiiie
B5S57_RS15080	COG1522	sequence-specific DNA binding
B5S57_RS15085	COG0686	Belongs to the AlaDH PNT family
B5S57_RS15095	COG0583	DNA-binding transcription factor activity
B5S57_RS15110	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
B5S57_RS15115	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
B5S57_RS15120	COG0776	regulation of translation
B5S57_RS15125	COG0539	negative regulation of cytoplasmic translation
B5S57_RS15130	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
B5S57_RS15135	COG1555	photosystem II stabilization
B5S57_RS15140	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B5S57_RS15145	COG0776	regulation of translation
B5S57_RS15150	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B5S57_RS15155	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
B5S57_RS15165	COG0544	peptidyl-prolyl cis-trans isomerase activity
B5S57_RS15185	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
B5S57_RS15190	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
B5S57_RS15195	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
B5S57_RS15205	COG1653	transport
B5S57_RS15210	COG2205	protein histidine kinase activity
B5S57_RS15220	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
B5S57_RS15225	COG1760	l-serine dehydratase
B5S57_RS15235	COG0513	Belongs to the DEAD box helicase family
B5S57_RS15245	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B5S57_RS15260	COG4628	conserved protein (DUF2132)
B5S57_RS15285	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B5S57_RS15290	COG0583	DNA-binding transcription factor activity
B5S57_RS15295	COG2951	lytic endotransglycosylase activity
B5S57_RS15300	COG3100	YcgL domain-containing protein
B5S57_RS15310	COG2894	cell division
B5S57_RS15315	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
B5S57_RS15320	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
B5S57_RS15325	COG0318	PFAM AMP-dependent synthetase and ligase
B5S57_RS15330	COG0596	Alpha beta hydrolase
B5S57_RS15345	COG1214	PFAM Peptidase M22, glycoprotease
B5S57_RS15350	COG1199	ATP-dependent helicase activity
B5S57_RS15360	COG0788	formyltetrahydrofolate deformylase activity
B5S57_RS15365	COG1902	pentaerythritol trinitrate reductase activity
B5S57_RS15365	COG0446	pyridine nucleotide-disulphide oxidoreductase
B5S57_RS15370	COG0616	signal peptide processing
B5S57_RS15375	COG0252	asparaginase activity
B5S57_RS15380	COG3139	Protein of unknown function (DUF1315)
B5S57_RS15390	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B5S57_RS15405	COG2226	methyltransferase
B5S57_RS15420	COG2983	Belongs to the UPF0260 family
B5S57_RS15430	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
B5S57_RS15445	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B5S57_RS15450	COG2832	Protein of unknown function (DUF454)
B5S57_RS15460	COG0745	RESPONSE REGULATOR receiver
B5S57_RS15465	COG0583	DNA-binding transcription factor activity
B5S57_RS15470	COG0778	Nitroreductase
B5S57_RS15475	COG1024	Enoyl-CoA hydratase
B5S57_RS15475	COG1250	3-hydroxyacyl-CoA dehydrogenase
B5S57_RS15480	COG0183	Belongs to the thiolase family
B5S57_RS15495	COG1595	DNA-templated transcription, initiation
B5S57_RS15505	COG2067	long-chain fatty acid transport protein
B5S57_RS15510	COG2067	long-chain fatty acid transport protein
B5S57_RS15515	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
B5S57_RS15520	COG2982	Protein involved in outer membrane biogenesis
B5S57_RS15525	COG0572	uridine kinase
B5S57_RS15530	COG0489	protein tyrosine kinase activity
B5S57_RS15535	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B5S57_RS15535	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B5S57_RS15545	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
B5S57_RS15555	COG0517	IMP dehydrogenase activity
B5S57_RS15555	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
B5S57_RS15555	COG0617	tRNA 3'-terminal CCA addition
B5S57_RS15560	COG2199	diguanylate cyclase activity
B5S57_RS15565	COG0314	molybdopterin synthase activity
B5S57_RS15570	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
B5S57_RS15580	COG0521	Mo-molybdopterin cofactor biosynthetic process
B5S57_RS15585	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B5S57_RS15590	COG0391	Required for morphogenesis under gluconeogenic growth conditions
B5S57_RS15595	COG2198	Histidine kinase
B5S57_RS15600	COG2204	response regulator
B5S57_RS15605	COG0556	nucleotide-excision repair
B5S57_RS15620	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
B5S57_RS15625	COG1028	Short-chain dehydrogenase reductase Sdr
B5S57_RS15630	COG1169	isochorismate synthase
B5S57_RS15635	COG1021	2,3-dihydroxybenzoate-AMP ligase
B5S57_RS15640	COG1535	isochorismatase
B5S57_RS15640	COG3433	isochorismatase activity
B5S57_RS15670	COG2382	esterase
B5S57_RS15675	COG4774	siderophore transport
B5S57_RS15675	COG1629	transport
B5S57_RS15685	COG4657	Part of a membrane complex involved in electron transport
B5S57_RS15690	COG2878	Part of a membrane complex involved in electron transport
B5S57_RS15695	COG4656	Part of a membrane complex involved in electron transport
B5S57_RS15700	COG4658	electron transport chain
B5S57_RS15705	COG4659	FMN binding
B5S57_RS15710	COG4660	Part of a membrane complex involved in electron transport
B5S57_RS15715	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
B5S57_RS15720	COG0346	lactoylglutathione lyase activity
B5S57_RS15730	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B5S57_RS15735	COG2056	Na+-H+ antiporter family
B5S57_RS15740	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
B5S57_RS15745	COG1286	toxin biosynthetic process
B5S57_RS15750	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
B5S57_RS15755	COG0285	dihydrofolate synthase activity
B5S57_RS15760	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
B5S57_RS15765	COG0101	tRNA pseudouridine synthase activity
B5S57_RS15775	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B5S57_RS15780	COG1263	PTS System
B5S57_RS15780	COG2190	(PTS) system
B5S57_RS15780	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B5S57_RS15785	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
B5S57_RS15790	COG1940	carbohydrate kinase activity
B5S57_RS15790	COG1846	Transcriptional regulator
B5S57_RS15795	COG4651	solute:proton antiporter activity
B5S57_RS15795	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B5S57_RS15800	COG0367	asparagine synthase
B5S57_RS15810	COG3104	oligopeptide transport
B5S57_RS15815	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
B5S57_RS15825	COG0326	Molecular chaperone. Has ATPase activity
B5S57_RS15830	COG3710	Transcriptional regulator
B5S57_RS15845	COG0622	Phosphoesterase
B5S57_RS15850	COG1090	epimerase
B5S57_RS15860	COG3118	belongs to the thioredoxin family
B5S57_RS15865	COG0330	HflC and HflK could
B5S57_RS15875	COG0789	Transcriptional regulator
B5S57_RS15895	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B5S57_RS15900	COG3115	cell septum assembly
B5S57_RS15905	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
B5S57_RS15910	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B5S57_RS15915	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B5S57_RS15920	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B5S57_RS15925	COG2190	(PTS) system
B5S57_RS15930	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B5S57_RS15935	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B5S57_RS15940	COG1702	phosphate starvation-inducible protein PhoH
B5S57_RS15945	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
B5S57_RS15950	COG4535	Mg2 and Co2 transporter CorC
B5S57_RS15955	COG0815	Transfers the fatty acyl group on membrane lipoproteins
B5S57_RS15960	COG2888	peptidyl-tyrosine sulfation
B5S57_RS15965	COG0495	leucyl-tRNA aminoacylation
B5S57_RS15970	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
B5S57_RS15975	COG1466	dna polymerase III delta subunit
B5S57_RS15980	COG0799	negative regulation of ribosome biogenesis
B5S57_RS15985	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
B5S57_RS15990	COG0768	penicillin binding
B5S57_RS15995	COG0772	Belongs to the SEDS family
B5S57_RS16000	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
B5S57_RS16005	COG1686	Belongs to the peptidase S11 family
B5S57_RS16010	COG2921	Belongs to the UPF0250 family
B5S57_RS16015	COG0321	lipoyl(octanoyl) transferase activity
B5S57_RS16020	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
B5S57_RS16050	COG1596	polysaccharide export
B5S57_RS16055	COG0489	protein tyrosine kinase activity
B5S57_RS16085	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
B5S57_RS16095	COG1045	serine acetyltransferase
B5S57_RS16135	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
B5S57_RS16140	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
B5S57_RS16145	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B5S57_RS16150	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B5S57_RS16155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B5S57_RS16190	COG2205	protein histidine kinase activity
B5S57_RS16195	COG0745	RESPONSE REGULATOR receiver
B5S57_RS16200	COG0366	Alpha amylase catalytic
B5S57_RS16205	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B5S57_RS16205	COG1263	PTS System
B5S57_RS16220	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
B5S57_RS16225	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B5S57_RS16230	COG2011	ABC-type metal ion transport system permease component
B5S57_RS16235	COG1464	Belongs to the NlpA lipoprotein family
B5S57_RS16240	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
B5S57_RS16265	COG1611	Belongs to the LOG family
B5S57_RS16270	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B5S57_RS16275	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
B5S57_RS16280	COG2363	Small membrane protein
B5S57_RS16285	COG0583	DNA-binding transcription factor activity
B5S57_RS16290	COG0301	tRNA thio-modification
B5S57_RS16290	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B5S57_RS16300	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
B5S57_RS16305	COG1722	exodeoxyribonuclease VII activity
B5S57_RS16310	COG0142	geranyltranstransferase activity
B5S57_RS16315	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
B5S57_RS16320	COG0564	pseudouridine synthase activity
B5S57_RS16325	COG3098	single-species biofilm formation
B5S57_RS16355	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B5S57_RS16360	COG0254	rRNA binding
B5S57_RS16365	COG1720	tRNA m6t6A37 methyltransferase activity
B5S57_RS16370	COG0442	prolyl-tRNA aminoacylation
B5S57_RS16375	COG2979	Protein of unknown function (DUF533)
B5S57_RS16395	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B5S57_RS16395	COG0047	phosphoribosylformylglycinamidine synthase activity
B5S57_RS16400	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
B5S57_RS16405	COG0590	tRNA wobble adenosine to inosine editing
B5S57_RS16410	COG0583	DNA-binding transcription factor activity
B5S57_RS16420	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
B5S57_RS16425	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
B5S57_RS16455	COG0484	heat shock protein binding
B5S57_RS16460	COG0443	Heat shock 70 kDa protein
B5S57_RS16465	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
B5S57_RS16470	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B5S57_RS16475	COG3033	Beta-eliminating lyase
B5S57_RS16480	COG0497	DNA recombination
B5S57_RS16485	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B5S57_RS16490	COG2914	Belongs to the UPF0125 (RnfH) family
B5S57_RS16495	COG2867	negative regulation of translational initiation
B5S57_RS16510	COG0582	viral genome integration into host DNA
B5S57_RS16515	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
B5S57_RS16535	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
B5S57_RS16540	COG1715	Restriction endonuclease
B5S57_RS16555	COG2003	Belongs to the UPF0758 family
B5S57_RS16705	COG3964	amidohydrolase
B5S57_RS16720	COG3711	transcriptional antiterminator
B5S57_RS16720	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B5S57_RS16750	COG1115	amino acid carrier protein
B5S57_RS16755	COG1584	GPR1 FUN34 yaaH family protein
B5S57_RS16765	COG0351	phosphomethylpyrimidine kinase
B5S57_RS16770	COG0519	Catalyzes the synthesis of GMP from XMP
B5S57_RS16770	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B5S57_RS16775	COG0516	GMP reductase activity
B5S57_RS16775	COG0517	IMP dehydrogenase activity
B5S57_RS16790	COG1160	GTP binding
B5S57_RS16795	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B5S57_RS16800	COG2976	Protein conserved in bacteria
B5S57_RS16805	COG0124	histidyl-tRNA synthetase
B5S57_RS16810	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
B5S57_RS16815	COG1426	Protein conserved in bacteria
B5S57_RS16830	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B5S57_RS16835	COG2975	iron-sulfur cluster assembly
B5S57_RS16840	COG0633	Ferredoxin
B5S57_RS16845	COG0443	Heat shock 70 kDa protein
B5S57_RS16855	COG0316	Belongs to the HesB IscA family
B5S57_RS16860	COG0822	iron-sulfur transferase activity
B5S57_RS16870	COG1959	2 iron, 2 sulfur cluster binding
B5S57_RS16875	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
B5S57_RS16880	COG0483	inositol monophosphate 1-phosphatase activity
B5S57_RS16885	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B5S57_RS16890	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B5S57_RS16895	COG1862	Preprotein translocase
B5S57_RS16900	COG0343	queuine tRNA-ribosyltransferase activity
B5S57_RS16910	COG0517	IMP dehydrogenase activity
B5S57_RS16920	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
B5S57_RS16925	COG0583	DNA-binding transcription factor activity
B5S57_RS16930	COG0450	alkyl hydroperoxide reductase
B5S57_RS16940	COG0704	Plays a role in the regulation of phosphate uptake
B5S57_RS16945	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B5S57_RS16950	COG0581	inorganic phosphate transmembrane transporter activity
B5S57_RS16960	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
B5S57_RS16965	COG0248	Ppx GppA phosphatase
B5S57_RS16975	COG5002	protein histidine kinase activity
B5S57_RS16980	COG0745	RESPONSE REGULATOR receiver
B5S57_RS16990	COG0826	peptidase U32
B5S57_RS16995	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
B5S57_RS17040	COG0542	response to heat
B5S57_RS17045	COG1496	oxidoreductase activity
B5S57_RS17050	COG0564	pseudouridine synthase activity
B5S57_RS17055	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B5S57_RS17060	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
B5S57_RS17065	COG1605	Chorismate mutase
B5S57_RS17065	COG0077	Prephenate dehydratase
B5S57_RS17070	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
B5S57_RS17075	COG5001	Diguanylate cyclase
B5S57_RS17080	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
B5S57_RS17085	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
B5S57_RS17095	COG0488	(ABC) transporter
B5S57_RS17105	COG1605	Chorismate mutase
B5S57_RS17105	COG0287	Prephenate dehydrogenase
B5S57_RS17110	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
B5S57_RS17115	COG3275	phosphorelay sensor kinase activity
B5S57_RS17120	COG3279	Response regulator of the LytR AlgR family
B5S57_RS17130	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
B5S57_RS17135	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
B5S57_RS17150	COG1966	Carbon starvation protein
B5S57_RS17155	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
B5S57_RS17160	COG1047	Peptidyl-prolyl cis-trans
B5S57_RS17165	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
B5S57_RS17175	COG0196	riboflavin kinase activity
B5S57_RS17180	COG0728	peptidoglycan biosynthetic process
B5S57_RS17185	COG0268	Binds directly to 16S ribosomal RNA
B5S57_RS17190	COG0640	Transcriptional regulator
B5S57_RS17195	COG0583	DNA-binding transcription factor activity
B5S57_RS17200	COG1283	sodium-dependent phosphate transmembrane transporter activity
B5S57_RS17210	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
B5S57_RS17245	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
B5S57_RS17255	COG0730	response to heat
B5S57_RS17265	COG0494	nUDIX hydrolase
B5S57_RS17275	COG0667	Aldo Keto reductase
B5S57_RS17285	COG2204	response regulator
B5S57_RS17290	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B5S57_RS17305	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
B5S57_RS17310	COG0513	Belongs to the DEAD box helicase family
B5S57_RS17335	COG3153	acetyltransferase
B5S57_RS17340	COG3154	lipid carrier protein
B5S57_RS17350	COG0826	peptidase U32
B5S57_RS17355	COG0826	peptidase U32
B5S57_RS17365	COG1846	Transcriptional regulator
B5S57_RS17380	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
B5S57_RS17385	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B5S57_RS17395	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
B5S57_RS17400	COG0195	Participates in both transcription termination and antitermination
B5S57_RS17405	COG0779	Required for maturation of 30S ribosomal subunits
B5S57_RS17420	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B5S57_RS17425	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B5S57_RS17430	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
B5S57_RS17435	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B5S57_RS17440	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
B5S57_RS17445	COG1534	Rna-binding protein
B5S57_RS17450	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B5S57_RS17460	COG2027	D-alanyl-D-alanine carboxypeptidase
B5S57_RS17465	COG2239	Acts as a magnesium transporter
B5S57_RS17475	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B5S57_RS17480	COG0739	heme binding
B5S57_RS17495	COG0316	Belongs to the HesB IscA family
B5S57_RS17500	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B5S57_RS17505	COG0628	permease
B5S57_RS17515	COG0784	Response regulator, receiver
B5S57_RS17515	COG2205	protein histidine kinase activity
B5S57_RS17530	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B5S57_RS17535	COG0444	Belongs to the ABC transporter superfamily
B5S57_RS17540	COG4608	Belongs to the ABC transporter superfamily
B5S57_RS17550	COG2971	BadF BadG BcrA BcrD
B5S57_RS17565	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B5S57_RS17580	COG1840	ABC-type Fe3 transport system, periplasmic component
B5S57_RS17585	COG0004	ammonium transporteR
B5S57_RS17595	COG3112	Uncharacterised protein family (UPF0231)
B5S57_RS17600	COG3835	regulator
B5S57_RS17605	COG2610	gluconate transmembrane transporter activity
B5S57_RS17610	COG1929	Belongs to the glycerate kinase type-1 family
B5S57_RS17615	COG1049	propionate catabolic process, 2-methylcitrate cycle
B5S57_RS17620	COG1752	Esterase of the alpha-beta hydrolase superfamily
B5S57_RS17625	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B5S57_RS17630	COG1643	Atp-dependent helicase
B5S57_RS17635	COG1489	DNA binding
B5S57_RS17640	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
B5S57_RS17645	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B5S57_RS17655	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
B5S57_RS17665	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
B5S57_RS17675	COG0842	Transport permease protein
B5S57_RS17680	COG1131	(ABC) transporter
B5S57_RS17685	COG0659	secondary active sulfate transmembrane transporter activity
B5S57_RS17690	COG0288	reversible hydration of carbon dioxide
B5S57_RS17705	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B5S57_RS17710	COG0508	dehydrogenase complex catalyzes the overall conversion of
B5S57_RS17715	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
B5S57_RS17720	COG2186	Transcriptional regulator
B5S57_RS17725	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
B5S57_RS17730	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B5S57_RS17735	COG4974	Belongs to the 'phage' integrase family
B5S57_RS17740	COG0716	FMN binding
B5S57_RS17750	COG0157	Belongs to the NadC ModD family
B5S57_RS17760	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B5S57_RS17765	COG1459	type II secretion system
B5S57_RS17775	COG0237	dephospho-CoA kinase activity
B5S57_RS17780	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
B5S57_RS17790	COG0335	large ribosomal subunit rRNA binding
B5S57_RS17795	COG0336	Belongs to the RNA methyltransferase TrmD family
B5S57_RS17800	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
B5S57_RS17805	COG0228	four-way junction DNA binding
B5S57_RS17810	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B5S57_RS17815	COG4137	Cytochrome C assembly protein
B5S57_RS17820	COG4536	flavin adenine dinucleotide binding
B5S57_RS17825	COG1854	S-ribosylhomocysteine lyase activity
B5S57_RS17835	COG0612	Peptidase, M16
B5S57_RS17840	COG1238	metal cluster binding
B5S57_RS17850	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
B5S57_RS17855	COG0511	ligase activity, forming carbon-carbon bonds
B5S57_RS17855	COG5016	pyruvate
B5S57_RS17860	COG3630	sodium ion export across plasma membrane
B5S57_RS17900	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
B5S57_RS17905	COG0527	aspartate kinase activity
B5S57_RS17910	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B5S57_RS17915	COG2137	regulation of response to DNA damage stimulus
B5S57_RS17920	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
B5S57_RS17925	COG1546	Belongs to the CinA family
B5S57_RS17930	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
B5S57_RS17935	COG4208	sulfate ABC transporter
B5S57_RS17945	COG4150	thiosulfate binding
B5S57_RS17955	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
B5S57_RS17960	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B5S57_RS17965	COG1388	LysM domain
B5S57_RS17965	COG4942	peptidase
B5S57_RS17970	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
B5S57_RS17975	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
B5S57_RS17980	COG0585	pseudouridine synthase activity
B5S57_RS17985	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
B5S57_RS17990	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
B5S57_RS17995	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
B5S57_RS18000	COG1968	undecaprenyl-diphosphatase activity
B5S57_RS18005	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
B5S57_RS18010	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
B5S57_RS18025	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B5S57_RS18030	COG0828	Belongs to the bacterial ribosomal protein bS21 family
B5S57_RS18035	COG1610	YqeY-like protein
B5S57_RS18040	COG0358	DNA primase activity
B5S57_RS18060	COG3550	peptidyl-serine autophosphorylation
B5S57_RS18080	COG0210	DNA helicase
B5S57_RS18150	COG4584	PFAM Integrase catalytic
B5S57_RS18155	COG1484	DNA-dependent DNA replication
B5S57_RS18280	COG2433	Pfam Transposase IS66
B5S57_RS18320	COG4104	PAAR repeat-containing protein
B5S57_RS18325	COG3501	Rhs element vgr protein
B5S57_RS18345	COG4932	domain protein
B5S57_RS18345	COG5492	domain, Protein
B5S57_RS18355	COG1349	DNA-binding transcription factor activity
B5S57_RS18365	COG3706	GGDEF domain
B5S57_RS18385	COG0668	transmembrane transport
B5S57_RS18390	COG0191	fructose-bisphosphate aldolase activity
B5S57_RS18395	COG0126	phosphoglycerate kinase activity
B5S57_RS18400	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B5S57_RS18405	COG4771	TonB-dependent receptor
B5S57_RS18410	COG0583	DNA-binding transcription factor activity
B5S57_RS18415	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
B5S57_RS18420	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
B5S57_RS18425	COG3091	SprT-like family
B5S57_RS18430	COG2356	endonuclease I
B5S57_RS18435	COG1385	rRNA (uridine-N3-)-methyltransferase activity
B5S57_RS18445	COG1678	Uncharacterized ACR, COG1678
B5S57_RS18450	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
B5S57_RS18465	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
B5S57_RS18470	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B5S57_RS18475	COG0762	integral membrane protein
B5S57_RS18480	COG1872	DUF167
B5S57_RS18490	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B5S57_RS18495	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B5S57_RS18500	COG2066	Belongs to the glutaminase family
B5S57_RS18515	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
B5S57_RS18520	COG0741	lytic transglycosylase activity
B5S57_RS18570	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
B5S57_RS18575	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
B5S57_RS18580	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B5S57_RS18585	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
B5S57_RS18590	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B5S57_RS18595	COG2967	ApaG domain
B5S57_RS18610	COG3610	response to peptide
B5S57_RS18615	COG2966	Psort location CytoplasmicMembrane, score
B5S57_RS18620	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B5S57_RS18625	COG0211	Belongs to the bacterial ribosomal protein bL27 family
B5S57_RS18630	COG0261	This protein binds to 23S rRNA in the presence of protein L20
B5S57_RS18640	COG0142	geranyltranstransferase activity
B5S57_RS18645	COG0531	amino acid
B5S57_RS18655	COG1438	arginine binding
B5S57_RS18665	COG2358	TRAP transporter, solute receptor (TAXI family
B5S57_RS18675	COG0589	response to stress
B5S57_RS18695	COG2235	arginine
B5S57_RS18700	COG0312	modulator of DNA gyrase
B5S57_RS18705	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B5S57_RS18710	COG3164	Protein of unknown function
B5S57_RS18720	COG0424	maF-like protein
B5S57_RS18725	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
B5S57_RS18730	COG1792	Involved in formation and maintenance of cell shape
B5S57_RS18735	COG1077	Cell shape determining protein MreB Mrl
B5S57_RS18770	COG2165	general secretion pathway protein
B5S57_RS18780	COG1459	type II secretion system
B5S57_RS18785	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B5S57_RS18795	COG3409	Peptidoglycan-binding domain 1 protein
B5S57_RS18795	COG3267	Type II secretory pathway component ExeA
B5S57_RS18820	COG2200	EAL domain
B5S57_RS18820	COG2199	diguanylate cyclase activity
B5S57_RS18825	COG0629	single-stranded DNA binding
B5S57_RS18840	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B5S57_RS18850	COG2239	Acts as a magnesium transporter
B5S57_RS18865	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
B5S57_RS18870	COG0527	aspartate kinase activity
B5S57_RS18875	COG1410	methionine synthase
B5S57_RS18875	COG0646	methionine synthase
B5S57_RS18950	COG0175	sulfate reduction
B5S57_RS18960	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
B5S57_RS18980	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B5S57_RS18985	COG0735	belongs to the Fur family
B5S57_RS19005	COG2433	Pfam Transposase IS66
B5S57_RS19010	COG0166	Belongs to the GPI family
B5S57_RS19015	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B5S57_RS19030	COG0359	binds to the 23S rRNA
B5S57_RS19040	COG2965	DNA replication, synthesis of RNA primer
B5S57_RS19045	COG0360	Binds together with S18 to 16S ribosomal RNA
B5S57_RS19050	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B5S57_RS19055	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B5S57_RS19060	COG0049	tRNA binding
B5S57_RS19075	COG2923	Belongs to the DsrF TusC family
B5S57_RS19080	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
B5S57_RS19085	COG2964	Protein conserved in bacteria
B5S57_RS19090	COG0545	Peptidyl-prolyl cis-trans isomerase
B5S57_RS19105	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
B5S57_RS19110	COG0330	HflC and HflK could
B5S57_RS19115	COG0330	HflC and HflK could
B5S57_RS19120	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B5S57_RS19130	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
B5S57_RS19135	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
B5S57_RS19145	COG0802	atpase or kinase
B5S57_RS19150	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
B5S57_RS19200	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
B5S57_RS19205	COG1162	GTPase activity
B5S57_RS19215	COG0490	domain, Protein
B5S57_RS19215	COG0471	metal ion transport
B5S57_RS19230	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
B5S57_RS19235	COG4942	peptidase
B5S57_RS19250	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
B5S57_RS19255	COG2816	NAD+ diphosphatase activity
B5S57_RS19260	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
B5S57_RS19265	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B5S57_RS19270	COG0085	RNA polymerase activity
B5S57_RS19275	COG0222	ribosome binding
B5S57_RS19280	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
B5S57_RS19295	COG0250	Participates in transcription elongation, termination and antitermination
B5S57_RS19300	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B5S57_RS19305	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B5S57_RS19330	COG1072	(Pantothenic acid kinase))
B5S57_RS19335	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
B5S57_RS19335	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
B5S57_RS19340	COG0812	UDP-N-acetylmuramate dehydrogenase activity
B5S57_RS19350	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B5S57_RS19395	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
B5S57_RS19410	COG3118	belongs to the thioredoxin family
B5S57_RS19420	COG0248	Ppx GppA phosphatase
B5S57_RS19425	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
B5S57_RS19430	COG0194	GDP metabolic process
B5S57_RS19435	COG1758	RNA polymerase activity
B5S57_RS19440	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B5S57_RS19445	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
B5S57_RS19450	COG2233	PERMEase
B5S57_RS19485	COG0583	DNA-binding transcription factor activity
B5S57_RS19505	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B5S57_RS19510	COG2183	response to ionizing radiation
B5S57_RS19520	COG0596	Alpha beta hydrolase
B5S57_RS19525	COG1040	competence protein
B5S57_RS19530	COG0316	Belongs to the HesB IscA family
B5S57_RS19530	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
B5S57_RS19535	COG0494	nUDIX hydrolase
B5S57_RS19540	COG1218	3'(2'),5'-bisphosphate nucleotidase
B5S57_RS19550	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
B5S57_RS19555	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
B5S57_RS19560	COG3156	type II secretion system protein K
B5S57_RS19565	COG4795	General secretion pathway protein
B5S57_RS19570	COG2165	general secretion pathway protein
B5S57_RS19575	COG2165	general secretion pathway protein
B5S57_RS19580	COG2165	general secretion pathway protein
B5S57_RS19585	COG1459	type II secretion system
B5S57_RS19590	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B5S57_RS19600	COG3031	protein transport across the cell outer membrane
B5S57_RS19605	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
B5S57_RS19610	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
B5S57_RS19615	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
B5S57_RS19625	COG0456	acetyltransferase
B5S57_RS19630	COG1490	D-aminoacyl-tRNA deacylase activity
B5S57_RS19635	COG1295	ribonuclease BN
B5S57_RS19640	COG1217	gtp-binding protein TYPA
B5S57_RS19645	COG0174	glutamine synthetase
B5S57_RS19655	COG3852	Histidine kinase
B5S57_RS19665	COG5001	Diguanylate cyclase
B5S57_RS19665	COG3300	MHYT domain
B5S57_RS19670	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
B5S57_RS19745	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
B5S57_RS19790	COG3550	peptidyl-serine autophosphorylation
B5S57_RS19830	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B5S57_RS19865	COG3250	beta-galactosidase activity
B5S57_RS19885	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B5S57_RS19890	COG0534	Mate efflux family protein
B5S57_RS19900	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B5S57_RS19905	COG2937	Belongs to the GPAT DAPAT family
B5S57_RS19915	COG3161	chorismate lyase activity
B5S57_RS19920	COG1580	Controls the rotational direction of flagella during chemotaxis
B5S57_RS19925	COG0705	Rhomboid family
B5S57_RS19935	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B5S57_RS19940	COG2177	Part of the ABC transporter FtsEX involved in
B5S57_RS19945	COG2884	Cell division ATP-binding protein ftsE
B5S57_RS19950	COG0552	protein localization to endoplasmic reticulum
B5S57_RS19955	COG0742	ribosomal rna small subunit methyltransferase
B5S57_RS20000	COG2433	Pfam Transposase IS66
B5S57_RS20015	COG2095	MarC family integral membrane protein
B5S57_RS20045	COG0783	Belongs to the Dps family
B5S57_RS20050	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
B5S57_RS20055	COG1280	lysine exporter protein (LysE YggA)
B5S57_RS20060	COG2267	carboxylic ester hydrolase activity
B5S57_RS20065	COG0561	phosphatase activity
B5S57_RS20075	COG3148	PFAM DTW domain containing protein
B5S57_RS20080	COG1011	Hydrolase
B5S57_RS20085	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
B5S57_RS20095	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
B5S57_RS20100	COG0019	diaminopimelate decarboxylase activity
B5S57_RS20130	COG1587	Uroporphyrinogen-III synthase
B5S57_RS20135	COG2959	enzyme of heme biosynthesis
B5S57_RS20140	COG3071	HemY protein
B5S57_RS20175	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
B5S57_RS20185	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B5S57_RS20190	COG0408	coproporphyrinogen oxidase activity
B5S57_RS20195	COG0009	L-threonylcarbamoyladenylate synthase
B5S57_RS20200	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
B5S57_RS20205	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
B5S57_RS20210	COG0551	DNA topoisomerase type I activity
B5S57_RS20235	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B5S57_RS20245	COG2801	Transposase and inactivated derivatives
B5S57_RS20280	COG0210	DNA helicase
B5S57_RS20310	COG2922	Belongs to the Smg family
B5S57_RS20315	COG0758	DNA mediated transformation
B5S57_RS20320	COG1652	LysM domain
B5S57_RS20325	COG0242	peptide deformylase activity
B5S57_RS20330	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B5S57_RS20335	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B5S57_RS20335	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B5S57_RS20340	COG0569	domain protein
B5S57_RS20345	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B5S57_RS20355	COG1272	protein, Hemolysin III
B5S57_RS20365	COG3084	Protein conserved in bacteria
B5S57_RS20380	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
B5S57_RS20385	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process