locus-tag	class	description
VAA_RS00015	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
VAA_RS00030	COG3118	belongs to the thioredoxin family
VAA_RS00040	COG0248	Ppx GppA phosphatase
VAA_RS00045	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
VAA_RS00050	COG0194	GDP metabolic process
VAA_RS00055	COG1758	RNA polymerase activity
VAA_RS00060	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VAA_RS00065	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
VAA_RS00070	COG2233	PERMEase
VAA_RS00105	COG0583	DNA-binding transcription factor activity
VAA_RS00125	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VAA_RS00130	COG2183	response to ionizing radiation
VAA_RS00145	COG1040	competence protein
VAA_RS00150	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
VAA_RS00150	COG0316	Belongs to the HesB IscA family
VAA_RS00155	COG0494	nUDIX hydrolase
VAA_RS00160	COG1218	3'(2'),5'-bisphosphate nucleotidase
VAA_RS00170	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VAA_RS00175	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VAA_RS00180	COG3156	type II secretion system protein K
VAA_RS00185	COG4795	General secretion pathway protein
VAA_RS00190	COG2165	general secretion pathway protein
VAA_RS00195	COG2165	general secretion pathway protein
VAA_RS00200	COG2165	general secretion pathway protein
VAA_RS00205	COG1459	type II secretion system
VAA_RS00210	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VAA_RS00220	COG3031	protein transport across the cell outer membrane
VAA_RS00225	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
VAA_RS00230	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
VAA_RS00235	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
VAA_RS00245	COG0456	acetyltransferase
VAA_RS00250	COG1490	D-aminoacyl-tRNA deacylase activity
VAA_RS00255	COG1295	ribonuclease BN
VAA_RS00260	COG1217	gtp-binding protein TYPA
VAA_RS00265	COG0174	glutamine synthetase
VAA_RS00275	COG3852	Histidine kinase
VAA_RS00285	COG3300	MHYT domain
VAA_RS00285	COG5001	Diguanylate cyclase
VAA_RS00290	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
VAA_RS00330	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
VAA_RS00375	COG3550	peptidyl-serine autophosphorylation
VAA_RS00415	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
VAA_RS00450	COG3250	beta-galactosidase activity
VAA_RS00470	COG0534	Mate efflux family protein
VAA_RS00485	COG2937	Belongs to the GPAT DAPAT family
VAA_RS00495	COG3161	chorismate lyase activity
VAA_RS00500	COG1580	Controls the rotational direction of flagella during chemotaxis
VAA_RS00505	COG0705	Rhomboid family
VAA_RS00515	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VAA_RS00520	COG2177	Part of the ABC transporter FtsEX involved in
VAA_RS00525	COG2884	Cell division ATP-binding protein ftsE
VAA_RS00530	COG0552	protein localization to endoplasmic reticulum
VAA_RS00535	COG0742	ribosomal rna small subunit methyltransferase
VAA_RS00545	COG2095	MarC family integral membrane protein
VAA_RS00580	COG2433	Pfam Transposase IS66
VAA_RS00585	COG2095	MarC family integral membrane protein
VAA_RS00610	COG0783	Belongs to the Dps family
VAA_RS00615	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VAA_RS00620	COG1280	lysine exporter protein (LysE YggA)
VAA_RS00625	COG2267	carboxylic ester hydrolase activity
VAA_RS00630	COG0561	phosphatase activity
VAA_RS00640	COG3148	PFAM DTW domain containing protein
VAA_RS00645	COG1011	Hydrolase
VAA_RS00650	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
VAA_RS00660	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
VAA_RS00665	COG0019	diaminopimelate decarboxylase activity
VAA_RS00685	COG1587	Uroporphyrinogen-III synthase
VAA_RS00695	COG3071	HemY protein
VAA_RS00730	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
VAA_RS00740	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
VAA_RS00745	COG0408	coproporphyrinogen oxidase activity
VAA_RS00750	COG0009	L-threonylcarbamoyladenylate synthase
VAA_RS00755	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
VAA_RS00760	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
VAA_RS00765	COG0551	DNA topoisomerase type I activity
VAA_RS00770	COG2922	Belongs to the Smg family
VAA_RS00780	COG1652	LysM domain
VAA_RS00785	COG0242	peptide deformylase activity
VAA_RS00790	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
VAA_RS00795	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VAA_RS00795	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VAA_RS00800	COG0569	domain protein
VAA_RS00805	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VAA_RS00815	COG1272	protein, Hemolysin III
VAA_RS00820	COG3084	Protein conserved in bacteria
VAA_RS00830	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
VAA_RS00835	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VAA_RS00845	COG2433	Pfam Transposase IS66
VAA_RS00920	COG0606	chelatase, subunit chli
VAA_RS00930	COG3978	acetolactate synthase activity
VAA_RS00935	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VAA_RS00965	COG0425	Belongs to the sulfur carrier protein TusA family
VAA_RS00980	COG0752	glycyl-tRNA synthetase alpha subunit
VAA_RS00990	COG3977	Valine--pyruvate aminotransferase
VAA_RS00995	COG0071	Belongs to the small heat shock protein (HSP20) family
VAA_RS01005	COG0187	DNA topoisomerase II activity
VAA_RS01010	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
VAA_RS01015	COG0592	DNA-directed DNA polymerase activity
VAA_RS01035	COG1126	abc transporter atp-binding protein
VAA_RS01050	COG0706	membrane insertase activity
VAA_RS01060	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VAA_RS01065	COG0445	tRNA wobble uridine modification
VAA_RS01075	COG1192	Involved in chromosome partitioning
VAA_RS01080	COG1475	DNA binding
VAA_RS01085	COG3312	ion transport
VAA_RS01100	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
VAA_RS01105	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
VAA_RS01110	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
VAA_RS01115	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
VAA_RS01125	COG0355	proton-transporting ATP synthase activity, rotational mechanism
VAA_RS01135	COG2814	Major facilitator Superfamily
VAA_RS01145	COG0183	Belongs to the thiolase family
VAA_RS01155	COG1739	Uncharacterized protein family UPF0029
VAA_RS01160	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VAA_RS01165	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
VAA_RS01210	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
VAA_RS01215	COG0352	thiamine-phosphate diphosphorylase activity
VAA_RS01225	COG2104	thiamine diphosphate biosynthetic process
VAA_RS01230	COG2022	thiamine diphosphate biosynthetic process
VAA_RS01235	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
VAA_RS01240	COG0006	proline dipeptidase activity
VAA_RS01240	COG0006	proline dipeptidase activity
VAA_RS01265	COG1522	sequence-specific DNA binding
VAA_RS01270	COG0742	ribosomal rna small subunit methyltransferase
VAA_RS01285	COG0589	response to stress
VAA_RS01290	COG1528	Iron-storage protein
VAA_RS01305	COG2081	HI0933 family
VAA_RS01315	COG1172	Belongs to the binding-protein-dependent transport system permease family
VAA_RS01320	COG1129	ABC transporter
VAA_RS01325	COG1879	ABC-type sugar transport system periplasmic component
VAA_RS01330	COG1069	ribulokinase activity
VAA_RS01340	COG2160	L-arabinose isomerase activity
VAA_RS01360	COG1322	Protein conserved in bacteria
VAA_RS01365	COG2226	methyltransferase
VAA_RS01375	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
VAA_RS01380	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VAA_RS01385	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VAA_RS01390	COG0805	protein transport
VAA_RS01395	COG0084	hydrolase, TatD family'
VAA_RS01405	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VAA_RS01405	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VAA_RS01425	COG3078	GTPase activator activity
VAA_RS01445	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
VAA_RS01450	COG2960	long-chain fatty acid transporting porin activity
VAA_RS01455	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VAA_RS01460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VAA_RS01465	COG1309	transcriptional regulator
VAA_RS01520	COG0601	transmembrane transport
VAA_RS01525	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VAA_RS01580	COG2433	Pfam Transposase IS66
VAA_RS01600	COG3081	Nucleoid-associated protein
VAA_RS01625	COG2433	Pfam Transposase IS66
VAA_RS01635	COG5290	Psort location Cytoplasmic, score
VAA_RS01670	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VAA_RS01675	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
VAA_RS01680	COG0339	signal peptide processing
VAA_RS01685	COG0210	DNA helicase
VAA_RS01690	COG1280	lysine exporter protein (LysE YggA)
VAA_RS01700	COG2962	Rard protein
VAA_RS01705	COG0514	ATP-dependent DNA helicase (RecQ)
VAA_RS01725	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
VAA_RS01730	COG1263	PTS System
VAA_RS01730	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VAA_RS01735	COG1132	(ABC) transporter
VAA_RS01740	COG4774	siderophore transport
VAA_RS01745	COG1120	ATPase activity
VAA_RS01770	COG0612	Peptidase, M16
VAA_RS01810	COG1061	Type III restriction enzyme res subunit
VAA_RS01845	COG1396	sequence-specific DNA binding
VAA_RS01860	COG1561	YicC-like family, N-terminal region
VAA_RS01865	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
VAA_RS01870	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
VAA_RS01875	COG1560	Kdo2-lipid A biosynthetic process
VAA_RS01880	COG1560	Kdo2-lipid A biosynthetic process
VAA_RS01885	COG1309	transcriptional regulator
VAA_RS01890	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
VAA_RS01895	COG2003	Belongs to the UPF0758 family
VAA_RS01900	COG0227	Belongs to the bacterial ribosomal protein bL28 family
VAA_RS01905	COG0267	Belongs to the bacterial ribosomal protein bL33 family
VAA_RS01915	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
VAA_RS01920	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
VAA_RS01925	COG0859	PFAM glycosyl transferase family 9
VAA_RS01930	COG0463	Glycosyl transferase, family 2
VAA_RS01935	COG0859	PFAM glycosyl transferase family 9
VAA_RS01940	COG3642	lipopolysaccharide core region biosynthetic process
VAA_RS01955	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
VAA_RS01965	COG1519	Transferase
VAA_RS01980	COG0859	PFAM glycosyl transferase family 9
VAA_RS01985	COG3307	-O-antigen
VAA_RS01995	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VAA_RS02020	COG1682	transport, permease protein
VAA_RS02065	COG0028	Belongs to the TPP enzyme family
VAA_RS02075	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
VAA_RS02080	COG0463	Glycosyl transferase, family 2
VAA_RS02110	COG3754	Rhamnan synthesis protein F
VAA_RS02135	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VAA_RS02145	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VAA_RS02165	COG1596	polysaccharide export
VAA_RS02170	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VAA_RS02205	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
VAA_RS02210	COG0438	transferase activity, transferring glycosyl groups
VAA_RS02225	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VAA_RS02230	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
VAA_RS02240	COG0668	transmembrane transport
VAA_RS02245	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VAA_RS02250	COG3068	Protein conserved in bacteria
VAA_RS02255	COG2852	Protein conserved in bacteria
VAA_RS02260	COG1253	flavin adenine dinucleotide binding
VAA_RS02265	COG0776	regulation of translation
VAA_RS02275	COG0151	Belongs to the GarS family
VAA_RS02285	COG0789	Transcriptional regulator
VAA_RS02295	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
VAA_RS02300	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VAA_RS02305	COG2264	protein methyltransferase activity
VAA_RS02310	COG0439	Biotin carboxylase
VAA_RS02315	COG0511	ligase activity, forming carbon-carbon bonds
VAA_RS02320	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
VAA_RS02325	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VAA_RS02340	COG2814	Major facilitator Superfamily
VAA_RS02345	COG0784	Response regulator, receiver
VAA_RS02345	COG2205	protein histidine kinase activity
VAA_RS02345	COG2198	Histidine kinase
VAA_RS02350	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VAA_RS02370	COG4232	protein-disulfide reductase activity
VAA_RS02375	COG1438	arginine binding
VAA_RS02380	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
VAA_RS02385	COG0540	Belongs to the ATCase OTCase family
VAA_RS02395	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
VAA_RS02400	COG0549	Belongs to the carbamate kinase family
VAA_RS02410	COG1288	antiporter activity
VAA_RS02420	COG1027	Aspartate ammonia-lyase
VAA_RS02425	COG3030	protein affecting phage T7 exclusion by the F plasmid
VAA_RS02430	COG1278	Cold shock
VAA_RS02435	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
VAA_RS02440	COG2205	protein histidine kinase activity
VAA_RS02445	COG0745	RESPONSE REGULATOR receiver
VAA_RS02455	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
VAA_RS02460	COG0205	6-phosphofructokinase activity
VAA_RS02465	COG1494	fructose-1,6-bisphosphatase
VAA_RS02470	COG3074	FtsZ-dependent cytokinesis
VAA_RS02475	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
VAA_RS02480	COG0527	aspartate kinase activity
VAA_RS02480	COG0460	homoserine dehydrogenase
VAA_RS02485	COG0626	cystathionine gamma-synthase activity
VAA_RS02495	COG0281	malic enzyme
VAA_RS02505	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
VAA_RS02510	COG1609	Transcriptional regulator
VAA_RS02520	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
VAA_RS02525	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
VAA_RS02530	COG1575	Belongs to the MenA family. Type 1 subfamily
VAA_RS02535	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VAA_RS02540	COG0534	Mate efflux family protein
VAA_RS02570	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
VAA_RS02575	COG0459	protein refolding
VAA_RS02590	COG1509	lysine 2,3-aminomutase activity
VAA_RS02595	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VAA_RS02605	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
VAA_RS02610	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
VAA_RS02615	COG1053	succinate dehydrogenase
VAA_RS02620	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
VAA_RS02625	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VAA_RS02635	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
VAA_RS02640	COG1045	serine acetyltransferase
VAA_RS02650	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
VAA_RS02655	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VAA_RS02660	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
VAA_RS02665	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VAA_RS02675	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VAA_RS02675	COG0165	Argininosuccinate lyase
VAA_RS02685	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VAA_RS02690	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VAA_RS02690	COG0678	peroxiredoxin activity
VAA_RS02700	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
VAA_RS02730	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
VAA_RS02735	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
VAA_RS02745	COG0338	D12 class N6 adenine-specific DNA methyltransferase
VAA_RS02750	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
VAA_RS02755	COG0546	phosphoglycolate phosphatase activity
VAA_RS02760	COG0180	Tryptophanyl-tRNA synthetase
VAA_RS02775	COG0583	DNA-binding transcription factor activity
VAA_RS02785	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VAA_RS02800	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
VAA_RS02810	COG1012	belongs to the aldehyde dehydrogenase family
VAA_RS02820	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VAA_RS02825	COG3954	Phosphoribulokinase
VAA_RS02835	COG0429	hydrolase of the alpha beta-hydrolase fold
VAA_RS02845	COG0488	(ABC) transporter
VAA_RS02850	COG2249	NAD(P)H dehydrogenase (quinone) activity
VAA_RS02860	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
VAA_RS02865	COG1047	Peptidyl-prolyl cis-trans
VAA_RS02875	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
VAA_RS02880	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
VAA_RS02885	COG0557	exoribonuclease II activity
VAA_RS02895	COG0051	transcription antitermination factor activity, RNA binding
VAA_RS02900	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
VAA_RS02905	COG0088	Forms part of the polypeptide exit tunnel
VAA_RS02915	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
VAA_RS02920	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
VAA_RS02935	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
VAA_RS02945	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
VAA_RS02955	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
VAA_RS02960	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
VAA_RS02965	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
VAA_RS02970	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
VAA_RS02975	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
VAA_RS02985	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
VAA_RS02990	COG1841	ribosomal large subunit assembly
VAA_RS02995	COG0200	Binds to the 23S rRNA
VAA_RS03000	COG0201	protein transport
VAA_RS03005	COG0257	Belongs to the bacterial ribosomal protein bL36 family
VAA_RS03010	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
VAA_RS03015	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
VAA_RS03020	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
VAA_RS03025	COG0202	RNA polymerase activity
VAA_RS03030	COG0203	ribosomal protein L17
VAA_RS03035	COG0545	Peptidyl-prolyl cis-trans isomerase
VAA_RS03040	COG3061	Opacity-associated protein A
VAA_RS03040	COG3266	domain, Protein
VAA_RS03045	COG2153	protein acetylation
VAA_RS03050	COG0513	Belongs to the DEAD box helicase family
VAA_RS03090	COG0737	Belongs to the 5'-nucleotidase family
VAA_RS03095	COG1648	precorrin-2 dehydrogenase activity
VAA_RS03095	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VAA_RS03100	COG0175	sulfate reduction
VAA_RS03105	COG2895	sulfate adenylyltransferase (ATP) activity
VAA_RS03110	COG0529	Catalyzes the synthesis of activated sulfate
VAA_RS03145	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
VAA_RS03150	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VAA_RS03155	COG0729	surface antigen
VAA_RS03160	COG2911	Protein conserved in bacteria
VAA_RS03165	COG2105	PFAM AIG2 family protein
VAA_RS03170	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
VAA_RS03175	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
VAA_RS03180	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VAA_RS03185	COG0163	prenyltransferase activity
VAA_RS03195	COG1178	ABC-type Fe3 transport system permease component
VAA_RS03200	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
VAA_RS03205	COG3028	Belongs to the UPF0307 family
VAA_RS03210	COG0312	modulator of DNA gyrase
VAA_RS03215	COG2239	Acts as a magnesium transporter
VAA_RS03220	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VAA_RS03225	COG1660	Displays ATPase and GTPase activities
VAA_RS03230	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VAA_RS03235	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VAA_RS03245	COG1137	ATPase activity
VAA_RS03250	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
VAA_RS03260	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
VAA_RS03265	COG0517	IMP dehydrogenase activity
VAA_RS03265	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
VAA_RS03275	COG1127	ABC transporter
VAA_RS03280	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
VAA_RS03285	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VAA_RS03290	COG2854	intermembrane phospholipid transfer
VAA_RS03300	COG5007	Belongs to the BolA IbaG family
VAA_RS03305	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
VAA_RS03310	COG0204	Acyl-transferase
VAA_RS03325	COG0251	oxidation-reduction process
VAA_RS03330	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
VAA_RS03345	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
VAA_RS03355	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
VAA_RS03365	COG0564	pseudouridine synthase activity
VAA_RS03370	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VAA_RS03375	COG0525	valine-tRNA ligase activity
VAA_RS03380	COG2927	DNA polymerase III (CHI subunit)
VAA_RS03385	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VAA_RS03390	COG0795	lipopolysaccharide-transporting ATPase activity
VAA_RS03395	COG0795	lipopolysaccharide-transporting ATPase activity
VAA_RS03490	COG0066	3-isopropylmalate dehydratase activity
VAA_RS03500	COG0473	3-isopropylmalate dehydrogenase activity
VAA_RS03520	COG0583	DNA-binding transcription factor activity
VAA_RS03525	COG1022	Amp-dependent synthetase and ligase
VAA_RS03530	COG0028	Belongs to the TPP enzyme family
VAA_RS03540	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VAA_RS03550	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
VAA_RS03555	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
VAA_RS03560	COG3079	Belongs to the UPF0149 family
VAA_RS03565	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VAA_RS03570	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VAA_RS03590	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
VAA_RS03600	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
VAA_RS03605	COG1595	DNA-templated transcription, initiation
VAA_RS03620	COG3086	response to oxidative stress
VAA_RS03625	COG0481	GTPase activity
VAA_RS03635	COG0571	ribonuclease III activity
VAA_RS03640	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
VAA_RS03645	COG1381	Involved in DNA repair and RecF pathway recombination
VAA_RS03650	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
VAA_RS03655	COG0736	holo-[acyl-carrier-protein] synthase activity
VAA_RS03665	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VAA_RS03670	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VAA_RS03675	COG3956	TIGRFAM MazG family protein
VAA_RS03680	COG0504	CTP synthase activity
VAA_RS03690	COG0617	tRNA 3'-terminal CCA addition
VAA_RS03695	COG3409	Peptidoglycan-binding domain 1 protein
VAA_RS03695	COG3267	Type II secretory pathway component ExeA
VAA_RS03705	COG4991	sh3 domain protein
VAA_RS03710	COG0306	phosphate transporter
VAA_RS03715	COG1392	Phosphate transport regulator
VAA_RS03720	COG3025	triphosphatase activity
VAA_RS03750	COG0494	nUDIX hydrolase
VAA_RS03755	COG3151	Protein conserved in bacteria
VAA_RS03765	COG3150	esterase
VAA_RS03770	COG0187	DNA topoisomerase II activity
VAA_RS03775	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
VAA_RS03780	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VAA_RS03785	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VAA_RS03790	COG3105	Protein conserved in bacteria
VAA_RS03795	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
VAA_RS03805	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
VAA_RS03815	COG0723	plastoquinol--plastocyanin reductase activity
VAA_RS03820	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
VAA_RS03825	COG2857	Cytochrome c1
VAA_RS03830	COG0625	glutathione transferase activity
VAA_RS03835	COG2969	positive regulation of protein catabolic process
VAA_RS03845	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VAA_RS03850	COG0792	nuclease activity
VAA_RS03855	COG3107	peptidoglycan biosynthetic process
VAA_RS03860	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
VAA_RS03865	COG0275	rRNA processing
VAA_RS03870	COG3116	cell division
VAA_RS03875	COG0768	penicillin binding
VAA_RS03880	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
VAA_RS03885	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
VAA_RS03895	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
VAA_RS03900	COG0772	Belongs to the SEDS family
VAA_RS03905	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
VAA_RS03910	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VAA_RS03915	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
VAA_RS03920	COG0849	cell division
VAA_RS03925	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
VAA_RS03930	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
VAA_RS03940	COG0653	protein targeting
VAA_RS03945	COG0494	nUDIX hydrolase
VAA_RS03950	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
VAA_RS03955	COG0505	Belongs to the CarA family
VAA_RS03960	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
VAA_RS03965	COG0730	response to heat
VAA_RS03970	COG0583	DNA-binding transcription factor activity
VAA_RS03975	COG2860	membrane
VAA_RS03980	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VAA_RS03990	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
VAA_RS04000	COG0493	'glutamate synthase
VAA_RS04005	COG0070	glutamate synthase
VAA_RS04005	COG0069	glutamate synthase activity
VAA_RS04005	COG0067	glutamate synthase
VAA_RS04015	COG0067	glutamate synthase
VAA_RS04015	COG0069	glutamate synthase activity
VAA_RS04015	COG0070	glutamate synthase
VAA_RS04020	COG1242	4 iron, 4 sulfur cluster binding
VAA_RS04025	COG0784	Response regulator, receiver
VAA_RS04025	COG5002	protein histidine kinase activity
VAA_RS04025	COG2198	Histidine kinase
VAA_RS04035	COG0745	RESPONSE REGULATOR receiver
VAA_RS04040	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VAA_RS04055	COG0083	homoserine kinase activity
VAA_RS04060	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
VAA_RS04065	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
VAA_RS04070	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
VAA_RS04075	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
VAA_RS04090	COG1115	amino acid carrier protein
VAA_RS04100	COG0084	hydrolase, TatD family'
VAA_RS04105	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VAA_RS04110	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
VAA_RS04115	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
VAA_RS04120	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
VAA_RS04125	COG0813	purine-nucleoside phosphorylase activity
VAA_RS04135	COG0560	Phosphoserine phosphatase
VAA_RS04145	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
VAA_RS04155	COG4628	conserved protein (DUF2132)
VAA_RS04160	COG1022	Amp-dependent synthetase and ligase
VAA_RS04165	COG0784	Response regulator, receiver
VAA_RS04165	COG3437	response regulator, receiver
VAA_RS04180	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VAA_RS04185	COG1085	galactose-1-phosphate uridylyltransferase
VAA_RS04195	COG1609	Transcriptional regulator
VAA_RS04225	COG2171	N-acyltransferase activity
VAA_RS04230	COG3141	response to X-ray
VAA_RS04245	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
VAA_RS04250	COG1074	ATP-dependent DNA helicase activity
VAA_RS04255	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
VAA_RS04265	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VAA_RS04265	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VAA_RS04275	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
VAA_RS04280	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
VAA_RS04285	COG2166	iron-sulfur cluster assembly
VAA_RS04290	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VAA_RS04300	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
VAA_RS04315	COG1595	DNA-templated transcription, initiation
VAA_RS04325	COG2211	Major facilitator Superfamily
VAA_RS04345	COG0271	Belongs to the BolA IbaG family
VAA_RS04380	COG1477	protein flavinylation
VAA_RS04390	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
VAA_RS04405	COG3706	GGDEF domain
VAA_RS04405	COG2203	Gaf domain
VAA_RS04405	COG4251	negative regulation of phosphorylation
VAA_RS04405	COG5001	Diguanylate cyclase
VAA_RS04410	COG0733	neurotransmitter:sodium symporter activity
VAA_RS04420	COG0189	ligase activity
VAA_RS04425	COG4067	protein conserved in archaea
VAA_RS04425	COG0189	ligase activity
VAA_RS04430	COG2195	Cleaves the N-terminal amino acid of tripeptides
VAA_RS04435	COG2252	PERMEase
VAA_RS04440	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
VAA_RS04455	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
VAA_RS04460	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
VAA_RS04465	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
VAA_RS04470	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VAA_RS04470	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VAA_RS04490	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VAA_RS04495	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
VAA_RS04500	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
VAA_RS04510	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
VAA_RS04515	COG0024	Methionine aminopeptidase
VAA_RS04520	COG0052	Belongs to the universal ribosomal protein uS2 family
VAA_RS04525	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
VAA_RS04535	COG0233	cytoplasmic translational termination
VAA_RS04540	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
VAA_RS04545	COG0575	Belongs to the CDS family
VAA_RS04550	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
VAA_RS04555	COG0750	zinc metalloprotease
VAA_RS04565	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
VAA_RS04570	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VAA_RS04575	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VAA_RS04585	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VAA_RS04595	COG0587	DNA-directed DNA polymerase activity
VAA_RS04600	COG0825	malonyl-CoA metabolic process
VAA_RS04605	COG0037	tRNA processing
VAA_RS04615	COG0347	Belongs to the P(II) protein family
VAA_RS04620	COG3021	interspecies interaction between organisms
VAA_RS04630	COG1388	LysM domain
VAA_RS04630	COG0741	lytic transglycosylase activity
VAA_RS04635	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VAA_RS04640	COG2226	methyltransferase
VAA_RS04645	COG0328	RNA-DNA hybrid ribonuclease activity
VAA_RS04665	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VAA_RS04670	COG0121	glutamine amidotransferase
VAA_RS04675	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
VAA_RS04680	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
VAA_RS04685	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
VAA_RS04690	COG1187	pseudouridine synthase activity
VAA_RS04715	COG2217	Heavy metal translocating P-type atpase
VAA_RS04715	COG2608	mercury ion transmembrane transporter activity
VAA_RS04760	COG2747	anti-sigma28 factor FlgM
VAA_RS04770	COG0835	chemotaxis
VAA_RS04770	COG0784	Response regulator, receiver
VAA_RS04780	COG1815	bacterial-type flagellum-dependent cell motility
VAA_RS04800	COG4787	bacterial-type flagellum-dependent cell motility
VAA_RS04810	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
VAA_RS04815	COG1706	bacterial-type flagellum-dependent cell motility
VAA_RS04820	COG1705	Flagellar rod assembly protein muramidase FlgJ
VAA_RS04820	COG3951	Flagellar rod assembly protein muramidase FlgJ
VAA_RS04830	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VAA_RS04920	COG0193	aminoacyl-tRNA hydrolase activity
VAA_RS04925	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
VAA_RS04935	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
VAA_RS04940	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
VAA_RS04945	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
VAA_RS04950	COG2890	protein-(glutamine-N5) methyltransferase activity
VAA_RS04955	COG3094	Invasion gene expression up-regulator, SirB
VAA_RS04960	COG2912	Transglutaminase-like superfamily
VAA_RS04965	COG2877	3-deoxy-8-phosphooctulonate synthase activity
VAA_RS04975	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
VAA_RS04980	COG2233	PERMEase
VAA_RS05000	COG1393	Belongs to the ArsC family
VAA_RS05005	COG4783	chaperone-mediated protein folding
VAA_RS05025	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
VAA_RS05040	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
VAA_RS05060	COG1393	Belongs to the ArsC family
VAA_RS05085	COG2837	iron assimilation
VAA_RS05110	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
VAA_RS05120	COG1516	flagellar protein fliS
VAA_RS05140	COG1677	Flagellar hook-basal body complex protein FliE
VAA_RS05150	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
VAA_RS05200	COG1987	bacterial-type flagellum assembly
VAA_RS05205	COG1684	flagellar biosynthetic protein fliR
VAA_RS05215	COG2840	Smr protein MutS2
VAA_RS05220	COG2890	protein-(glutamine-N5) methyltransferase activity
VAA_RS05225	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
VAA_RS05230	COG2860	membrane
VAA_RS05235	COG3101	peptidyl-lysine hydroxylation
VAA_RS05245	COG0431	NADPH-dependent FMN reductase
VAA_RS05250	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
VAA_RS05250	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VAA_RS05255	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VAA_RS05260	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VAA_RS05265	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VAA_RS05270	COG0735	belongs to the Fur family
VAA_RS05280	COG0583	DNA-binding transcription factor activity
VAA_RS05290	COG1346	cytolysis
VAA_RS05305	COG0596	Alpha beta hydrolase
VAA_RS05310	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
VAA_RS05315	COG0033	Phosphoglucomutase
VAA_RS05325	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
VAA_RS05340	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
VAA_RS05355	COG0567	Dehydrogenase, E1 component
VAA_RS05360	COG0508	dehydrogenase complex catalyzes the overall conversion of
VAA_RS05375	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VAA_RS05380	COG1121	(ABC) transporter
VAA_RS05385	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
VAA_RS05390	COG4977	sequence-specific DNA binding
VAA_RS05395	COG1918	ferrous iron import across plasma membrane
VAA_RS05420	COG3102	Protein conserved in bacteria
VAA_RS05425	COG1025	Belongs to the peptidase M16 family
VAA_RS05430	COG2062	phosphohistidine phosphatase, SixA
VAA_RS05435	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
VAA_RS05460	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
VAA_RS05465	COG2198	Histidine kinase
VAA_RS05465	COG0643	Histidine kinase
VAA_RS05465	COG0784	Response regulator, receiver
VAA_RS05470	COG2201	protein-glutamate methylesterase activity
VAA_RS05475	COG1192	Involved in chromosome partitioning
VAA_RS05485	COG0835	chemotaxis
VAA_RS05495	COG4133	protoheme IX ABC transporter activity
VAA_RS05500	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VAA_RS05505	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VAA_RS05515	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
VAA_RS05520	COG1138	Cytochrome C-type biogenesis protein
VAA_RS05525	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VAA_RS05540	COG2853	Lipoprotein
VAA_RS05560	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
VAA_RS05565	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VAA_RS05580	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
VAA_RS05585	COG0243	molybdopterin cofactor binding
VAA_RS05595	COG3083	sulfuric ester hydrolase activity
VAA_RS05600	COG3082	Protein of unknown function (DUF1414)
VAA_RS05615	COG1757	Na H antiporter
VAA_RS05620	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VAA_RS05625	COG2095	MarC family integral membrane protein
VAA_RS05630	COG1454	alcohol dehydrogenase
VAA_RS05630	COG1012	belongs to the aldehyde dehydrogenase family
VAA_RS05640	COG1530	ribonuclease E activity
VAA_RS05645	COG0564	pseudouridine synthase activity
VAA_RS05650	COG0424	maF-like protein
VAA_RS05655	COG1399	metal-binding, possibly nucleic acid-binding protein
VAA_RS05670	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VAA_RS05695	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VAA_RS05700	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
VAA_RS05705	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
VAA_RS05710	COG0470	DNA polymerase III
VAA_RS05715	COG0084	hydrolase, TatD family'
VAA_RS05720	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VAA_RS05720	COG1263	PTS System
VAA_RS05725	COG0733	neurotransmitter:sodium symporter activity
VAA_RS05740	COG4667	esterase of the alpha-beta hydrolase superfamily
VAA_RS05750	COG1940	carbohydrate kinase activity
VAA_RS05755	COG0784	Response regulator, receiver
VAA_RS05755	COG0835	chemotaxis
VAA_RS05760	COG1028	Short-chain dehydrogenase reductase Sdr
VAA_RS05765	COG0616	signal peptide processing
VAA_RS05780	COG0232	Belongs to the dGTPase family. Type 2 subfamily
VAA_RS05785	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
VAA_RS05790	COG0436	Aminotransferase
VAA_RS05795	COG1169	isochorismate synthase
VAA_RS05800	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
VAA_RS05810	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
VAA_RS05860	COG1522	sequence-specific DNA binding
VAA_RS05865	COG1946	Acyl-CoA thioesterase
VAA_RS05870	COG3126	Type III secretion system lipoprotein chaperone (YscW)
VAA_RS05885	COG3706	GGDEF domain
VAA_RS05905	COG1022	Amp-dependent synthetase and ligase
VAA_RS05915	COG4221	oxidoreductase activity
VAA_RS05925	COG0745	RESPONSE REGULATOR receiver
VAA_RS05930	COG0642	Histidine kinase
VAA_RS05935	COG2194	sulfuric ester hydrolase activity
VAA_RS05950	COG2985	domain, Protein
VAA_RS05960	COG3850	Histidine kinase
VAA_RS05960	COG5002	protein histidine kinase activity
VAA_RS05975	COG1609	Transcriptional regulator
VAA_RS05980	COG0129	dihydroxy-acid dehydratase activity
VAA_RS05985	COG3265	gluconokinase activity
VAA_RS05990	COG2610	gluconate transmembrane transporter activity
VAA_RS05995	COG0800	Aldolase
VAA_RS06020	COG1028	Short-chain dehydrogenase reductase Sdr
VAA_RS06025	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VAA_RS06030	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VAA_RS06060	COG1216	Glycosyl transferase, family 2
VAA_RS06080	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VAA_RS06085	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VAA_RS06110	COG5002	protein histidine kinase activity
VAA_RS06110	COG0784	Response regulator, receiver
VAA_RS06125	COG0601	transmembrane transport
VAA_RS06130	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VAA_RS06135	COG0444	Belongs to the ABC transporter superfamily
VAA_RS06145	COG0435	Glutathione S-transferase
VAA_RS06150	COG0857	belongs to the CobB CobQ family
VAA_RS06150	COG0280	phosphate acetyltransferase
VAA_RS06155	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
VAA_RS06160	COG3092	negative regulation of chromosome organization
VAA_RS06170	COG4120	Belongs to the binding-protein-dependent transport system permease family
VAA_RS06180	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VAA_RS06185	COG0653	protein targeting
VAA_RS06190	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
VAA_RS06195	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
VAA_RS06205	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
VAA_RS06210	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
VAA_RS06215	COG0156	8-amino-7-oxononanoate synthase activity
VAA_RS06220	COG2226	methyltransferase
VAA_RS06225	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
VAA_RS06235	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VAA_RS06240	COG2186	Transcriptional regulator
VAA_RS06255	COG0537	adenosine 5'-monophosphoramidase activity
VAA_RS06280	COG3150	esterase
VAA_RS06285	COG1252	NADH dehydrogenase
VAA_RS06300	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
VAA_RS06310	COG4591	ABC-type transport system involved in lipoprotein release permease component
VAA_RS06315	COG1136	(ABC) transporter
VAA_RS06320	COG4591	ABC-type transport system involved in lipoprotein release permease component
VAA_RS06330	COG2333	competence protein COMEC
VAA_RS06330	COG0658	competence protein
VAA_RS06335	COG1132	(ABC) transporter
VAA_RS06350	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
VAA_RS06360	COG2719	SpoVR family
VAA_RS06365	COG2718	Belongs to the UPF0229 family
VAA_RS06370	COG2766	serine protein kinase
VAA_RS06375	COG3013	Belongs to the UPF0304 family
VAA_RS06385	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VAA_RS06400	COG1882	Formate acetyltransferase
VAA_RS06430	COG4160	amino acid transport
VAA_RS06435	COG0708	Exodeoxyribonuclease III
VAA_RS06440	COG0840	transmembrane signaling receptor activity
VAA_RS06450	COG3923	Primosomal replication protein n
VAA_RS06460	COG1199	ATP-dependent helicase activity
VAA_RS06470	COG3012	SEC-C Motif Domain Protein
VAA_RS06475	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VAA_RS06485	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VAA_RS06490	COG0215	cysteine-tRNA ligase activity
VAA_RS06495	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
VAA_RS06500	COG0632	four-way junction helicase activity
VAA_RS06505	COG2255	four-way junction helicase activity
VAA_RS06510	COG1271	oxidase subunit
VAA_RS06515	COG1294	oxidase, subunit
VAA_RS06525	COG3790	cyd operon protein YbgE
VAA_RS06530	COG0824	Thioesterase
VAA_RS06535	COG0811	peptide transport
VAA_RS06550	COG0823	Involved in the tonB-independent uptake of proteins
VAA_RS06555	COG2885	chlorophyll binding
VAA_RS06560	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
VAA_RS06565	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
VAA_RS06570	COG2433	Pfam Transposase IS66
VAA_RS06590	COG0784	Response regulator, receiver
VAA_RS06590	COG5002	protein histidine kinase activity
VAA_RS06605	COG0582	viral genome integration into host DNA
VAA_RS06620	COG1401	restriction endodeoxyribonuclease activity
VAA_RS06640	COG5001	Diguanylate cyclase
VAA_RS06640	COG3300	MHYT domain
VAA_RS06665	COG1960	acyl-CoA dehydrogenase activity
VAA_RS06670	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VAA_RS06700	COG0277	FAD linked oxidase domain protein
VAA_RS06700	COG0247	lactate metabolic process
VAA_RS06715	COG2986	histidine ammonia-lyase
VAA_RS06725	COG0010	Belongs to the arginase family
VAA_RS06730	COG1228	amidohydrolase
VAA_RS06745	COG3099	Belongs to the UPF0263 family
VAA_RS06750	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VAA_RS06760	COG0417	DNA replication proofreading
VAA_RS06765	COG2197	response regulator
VAA_RS06770	COG0322	excinuclease ABC activity
VAA_RS06815	COG0072	phenylalanine-tRNA ligase activity
VAA_RS06815	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VAA_RS06820	COG0776	regulation of translation
VAA_RS06830	COG0500	methyltransferase
VAA_RS06845	COG5001	Diguanylate cyclase
VAA_RS06855	COG1346	cytolysis
VAA_RS06860	COG1380	Effector of murein hydrolase LrgA
VAA_RS06865	COG2925	Exonuclease
VAA_RS06870	COG1823	symporter activity
VAA_RS06875	COG0702	epimerase
VAA_RS06905	COG2994	toxin metabolic process
VAA_RS06910	COG1073	alpha beta
VAA_RS06910	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
VAA_RS06910	COG3064	Membrane
VAA_RS06915	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
VAA_RS06920	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
VAA_RS06935	COG2988	succinylglutamate desuccinylase activity
VAA_RS06940	COG4139	cobalamin transport
VAA_RS06945	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
VAA_RS06965	COG0583	DNA-binding transcription factor activity
VAA_RS06975	COG1451	nucleotide metabolic process
VAA_RS06990	COG3063	Type IV pilus biogenesis stability protein PilW
VAA_RS07030	COG3290	protein histidine kinase activity
VAA_RS07035	COG4565	transcriptional regulatory protein
VAA_RS07045	COG0784	Response regulator, receiver
VAA_RS07045	COG0835	chemotaxis
VAA_RS07085	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
VAA_RS07160	COG1181	Belongs to the D-alanine--D-alanine ligase family
VAA_RS07180	COG1716	ATPase activity
VAA_RS07205	COG4991	sh3 domain protein
VAA_RS07205	COG3064	Membrane
VAA_RS07205	COG0515	serine threonine protein kinase
VAA_RS07255	COG2433	Pfam Transposase IS66
VAA_RS07275	COG0251	oxidation-reduction process
VAA_RS07280	COG1294	oxidase, subunit
VAA_RS07300	COG3220	belongs to the UPF0276 family
VAA_RS07325	COG0840	transmembrane signaling receptor activity
VAA_RS07335	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VAA_RS07340	COG2200	EAL domain
VAA_RS07350	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VAA_RS07350	COG1263	PTS System
VAA_RS07360	COG1621	beta-fructofuranosidase activity
VAA_RS07365	COG0840	transmembrane signaling receptor activity
VAA_RS07375	COG1054	Belongs to the UPF0176 family
VAA_RS07380	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
VAA_RS07385	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VAA_RS07395	COG0848	biopolymer transport protein
VAA_RS07400	COG0811	peptide transport
VAA_RS07405	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
VAA_RS07410	COG3721	Heme iron utilization protein
VAA_RS07415	COG0748	coenzyme F420 binding
VAA_RS07420	COG1629	transport
VAA_RS07420	COG4771	TonB-dependent receptor
VAA_RS07425	COG1940	carbohydrate kinase activity
VAA_RS07455	COG2989	Protein conserved in bacteria
VAA_RS07460	COG3108	Peptidase M15
VAA_RS07465	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VAA_RS07480	COG1846	Transcriptional regulator
VAA_RS07485	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VAA_RS07500	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
VAA_RS07505	COG1448	Aminotransferase
VAA_RS07510	COG2770	Histidine kinase
VAA_RS07510	COG3437	response regulator, receiver
VAA_RS07515	COG0840	transmembrane signaling receptor activity
VAA_RS07520	COG0745	RESPONSE REGULATOR receiver
VAA_RS07530	COG0643	Histidine kinase
VAA_RS07530	COG2198	Histidine kinase
VAA_RS07540	COG0835	chemotaxis
VAA_RS07545	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
VAA_RS07550	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
VAA_RS07555	COG2201	protein-glutamate methylesterase activity
VAA_RS07565	COG0017	Asparaginyl-tRNA synthetase
VAA_RS07570	COG0840	transmembrane signaling receptor activity
VAA_RS07575	COG0720	synthase
VAA_RS07580	COG2356	endonuclease I
VAA_RS07590	COG1760	l-serine dehydratase
VAA_RS07595	COG0814	amino acid
VAA_RS07600	COG0494	nUDIX hydrolase
VAA_RS07605	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VAA_RS07615	COG3106	COG3106 Predicted ATPase
VAA_RS07620	COG3768	UPF0283 membrane protein
VAA_RS07630	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VAA_RS07650	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VAA_RS07660	COG0471	metal ion transport
VAA_RS07665	COG4191	Histidine kinase
VAA_RS07665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VAA_RS07675	COG1278	Cold shock
VAA_RS07680	COG3005	denitrification pathway
VAA_RS07690	COG0513	Belongs to the DEAD box helicase family
VAA_RS07695	COG2723	6-phospho-beta-galactosidase activity
VAA_RS07700	COG1609	Transcriptional regulator
VAA_RS07745	COG5002	protein histidine kinase activity
VAA_RS07745	COG5001	Diguanylate cyclase
VAA_RS07765	COG1643	Atp-dependent helicase
VAA_RS07775	COG0583	DNA-binding transcription factor activity
VAA_RS07780	COG0477	Major facilitator Superfamily
VAA_RS07795	COG0673	inositol 2-dehydrogenase activity
VAA_RS07800	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VAA_RS07805	COG0517	IMP dehydrogenase activity
VAA_RS07805	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
VAA_RS07810	COG2176	DNA-directed DNA polymerase activity
VAA_RS07820	COG3718	enzyme involved in inositol metabolism
VAA_RS07825	COG3962	Belongs to the TPP enzyme family
VAA_RS07830	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VAA_RS07855	COG0673	inositol 2-dehydrogenase activity
VAA_RS07860	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
VAA_RS07900	COG1204	response to ionizing radiation
VAA_RS07920	COG2433	Pfam Transposase IS66
VAA_RS07930	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
VAA_RS07935	COG1280	lysine exporter protein (LysE YggA)
VAA_RS07940	COG1115	amino acid carrier protein
VAA_RS07955	COG2195	Cleaves the N-terminal amino acid of tripeptides
VAA_RS07965	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
VAA_RS07975	COG0625	glutathione transferase activity
VAA_RS08005	COG0811	peptide transport
VAA_RS08010	COG0811	peptide transport
VAA_RS08015	COG0848	biopolymer transport protein
VAA_RS08030	COG4667	esterase of the alpha-beta hydrolase superfamily
VAA_RS08035	COG1793	dna ligase
VAA_RS08050	COG3001	Fructosamine kinase
VAA_RS08060	COG0791	NLP P60 protein
VAA_RS08065	COG0840	transmembrane signaling receptor activity
VAA_RS08075	COG3148	PFAM DTW domain containing protein
VAA_RS08080	COG1940	carbohydrate kinase activity
VAA_RS08090	COG1763	Mo-molybdopterin cofactor biosynthetic process
VAA_RS08095	COG0746	molybdenum cofactor guanylyltransferase activity
VAA_RS08100	COG3842	ATPase activity
VAA_RS08110	COG1840	ABC-type Fe3 transport system, periplasmic component
VAA_RS08115	COG2271	Major facilitator Superfamily
VAA_RS08125	COG2197	response regulator
VAA_RS08130	COG0488	(ABC) transporter
VAA_RS08135	COG0004	ammonium transporteR
VAA_RS08140	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
VAA_RS08150	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VAA_RS08155	COG1177	transmembrane transport
VAA_RS08160	COG1176	ABC-type spermidine putrescine transport system, permease component I
VAA_RS08165	COG3842	ATPase activity
VAA_RS08190	COG0589	response to stress
VAA_RS08195	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VAA_RS08210	COG2217	Heavy metal translocating P-type atpase
VAA_RS08220	COG2010	Cytochrome c
VAA_RS08235	COG3278	Belongs to the heme-copper respiratory oxidase family
VAA_RS08260	COG3120	sequence-specific DNA binding
VAA_RS08265	COG1067	ATP-dependent peptidase activity
VAA_RS08270	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VAA_RS08285	COG0488	(ABC) transporter
VAA_RS08295	COG0116	Belongs to the methyltransferase superfamily
VAA_RS08295	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VAA_RS08305	COG0167	dihydroorotate dehydrogenase activity
VAA_RS08320	COG0308	aminopeptidase N
VAA_RS08335	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
VAA_RS08340	COG1956	GAF domain-containing protein
VAA_RS08345	COG1132	(ABC) transporter
VAA_RS08350	COG2995	paraquat-inducible protein a
VAA_RS08365	COG2996	Protein conserved in bacteria
VAA_RS08385	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VAA_RS08390	COG1666	GTP binding
VAA_RS08400	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VAA_RS08400	COG1648	precorrin-2 dehydrogenase activity
VAA_RS08405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VAA_RS08410	COG4597	amino acid ABC transporter
VAA_RS08415	COG0765	amino acid transport
VAA_RS08420	COG1126	abc transporter atp-binding protein
VAA_RS08425	COG0670	Belongs to the BI1 family
VAA_RS08430	COG2920	part of a sulfur-relay system
VAA_RS08435	COG1254	Belongs to the acylphosphatase family
VAA_RS08440	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VAA_RS08450	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VAA_RS08480	COG0602	queuosine metabolic process
VAA_RS08485	COG0561	phosphatase activity
VAA_RS08505	COG2828	Protein conserved in bacteria
VAA_RS08510	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
VAA_RS08515	COG0372	Belongs to the citrate synthase family
VAA_RS08520	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
VAA_RS08550	COG0745	RESPONSE REGULATOR receiver
VAA_RS08555	COG5002	protein histidine kinase activity
VAA_RS08560	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
VAA_RS08565	COG1902	pentaerythritol trinitrate reductase activity
VAA_RS08580	COG1129	ABC transporter
VAA_RS08600	COG1342	Belongs to the UPF0251 family
VAA_RS08610	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VAA_RS08620	COG2207	Transcriptional regulator
VAA_RS08625	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VAA_RS08625	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VAA_RS08625	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VAA_RS08650	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
VAA_RS08660	COG3051	citrate lyase alpha subunit
VAA_RS08665	COG2301	Belongs to the HpcH HpaI aldolase family
VAA_RS08675	COG4565	transcriptional regulatory protein
VAA_RS08685	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
VAA_RS08690	COG5016	pyruvate
VAA_RS08690	COG0511	ligase activity, forming carbon-carbon bonds
VAA_RS08705	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
VAA_RS08725	COG0840	transmembrane signaling receptor activity
VAA_RS08735	COG0840	transmembrane signaling receptor activity
VAA_RS08745	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VAA_RS08755	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VAA_RS08785	COG0840	transmembrane signaling receptor activity
VAA_RS08810	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VAA_RS08825	COG4181	ATPase activity
VAA_RS08830	COG0534	Mate efflux family protein
VAA_RS08835	COG0702	epimerase
VAA_RS08845	COG2814	Major facilitator Superfamily
VAA_RS08850	COG1187	pseudouridine synthase activity
VAA_RS08855	COG1061	Type III restriction enzyme res subunit
VAA_RS08870	COG2205	protein histidine kinase activity
VAA_RS08875	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
VAA_RS08920	COG0564	pseudouridine synthase activity
VAA_RS08925	COG0733	neurotransmitter:sodium symporter activity
VAA_RS08935	COG0626	cystathionine gamma-synthase activity
VAA_RS08940	COG0519	Catalyzes the synthesis of GMP from XMP
VAA_RS08955	COG1842	Phage shock protein A
VAA_RS08960	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
VAA_RS08975	COG4171	peptide transport system, permease
VAA_RS08985	COG4172	Belongs to the ABC transporter superfamily
VAA_RS09000	COG1227	inorganic diphosphatase activity
VAA_RS09010	COG0243	molybdopterin cofactor binding
VAA_RS09015	COG3005	denitrification pathway
VAA_RS09020	COG4459	periplasmic nitrate reductase
VAA_RS09025	COG2116	formate transmembrane transporter activity
VAA_RS09050	COG1434	Gram-negative-bacterium-type cell wall biogenesis
VAA_RS09055	COG1435	thymidine kinase activity
VAA_RS09060	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
VAA_RS09065	COG1801	Protein of unknown function DUF72
VAA_RS09075	COG4106	trans-aconitate 2-methyltransferase activity
VAA_RS09080	COG0500	methyltransferase
VAA_RS09085	COG4067	protein conserved in archaea
VAA_RS09085	COG0189	ligase activity
VAA_RS09100	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
VAA_RS09105	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
VAA_RS09115	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VAA_RS09120	COG1434	Gram-negative-bacterium-type cell wall biogenesis
VAA_RS09125	COG0745	RESPONSE REGULATOR receiver
VAA_RS09135	COG1609	Transcriptional regulator
VAA_RS09140	COG3070	regulator of competence-specific genes
VAA_RS09160	COG0297	glycogen (starch) synthase activity
VAA_RS09165	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
VAA_RS09170	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VAA_RS09185	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
VAA_RS09190	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
VAA_RS09195	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
VAA_RS09200	COG0542	response to heat
VAA_RS09205	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
VAA_RS09210	COG1278	Cold shock
VAA_RS09225	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
VAA_RS09225	COG0140	phosphoribosyl-ATP diphosphatase activity
VAA_RS09230	COG0107	imidazoleglycerol-phosphate synthase activity
VAA_RS09235	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
VAA_RS09240	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
VAA_RS09245	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VAA_RS09245	COG0131	Imidazoleglycerol-phosphate dehydratase
VAA_RS09250	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VAA_RS09255	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
VAA_RS09260	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
VAA_RS09265	COG1757	Na H antiporter
VAA_RS09270	COG2916	Histone family protein nucleoid-structuring protein H-NS
VAA_RS09275	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VAA_RS09285	COG0482	sulfurtransferase activity
VAA_RS09290	COG2915	High frequency lysogenization protein hflD homolog
VAA_RS09295	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
VAA_RS09300	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
VAA_RS09310	COG4191	Histidine kinase
VAA_RS09310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VAA_RS09325	COG3070	regulator of competence-specific genes
VAA_RS09335	COG2431	L-lysine efflux transmembrane transporter activity
VAA_RS09345	COG0076	glutamate decarboxylase activity
VAA_RS09350	COG1737	Transcriptional regulator
VAA_RS09360	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VAA_RS09365	COG2985	domain, Protein
VAA_RS09365	COG3273	potassium ion transport
VAA_RS09370	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
VAA_RS09380	COG0281	malic enzyme
VAA_RS09390	COG2949	membrane
VAA_RS09410	COG0492	ferredoxin-NADP+ reductase activity
VAA_RS09415	COG4988	ABC transporter
VAA_RS09420	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
VAA_RS09435	COG1595	DNA-templated transcription, initiation
VAA_RS09450	COG1187	pseudouridine synthase activity
VAA_RS09455	COG0009	L-threonylcarbamoyladenylate synthase
VAA_RS09470	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VAA_RS09475	COG0512	Glutamine amidotransferase of anthranilate synthase
VAA_RS09480	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
VAA_RS09485	COG0135	phosphoribosylanthranilate isomerase activity
VAA_RS09485	COG0134	indole-3-glycerol-phosphate synthase activity
VAA_RS09490	COG0133	tryptophan synthase activity
VAA_RS09495	COG0159	tryptophan synthase activity
VAA_RS09525	COG2350	Protein conserved in bacteria
VAA_RS09535	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
VAA_RS09540	COG0583	DNA-binding transcription factor activity
VAA_RS09555	COG2203	Gaf domain
VAA_RS09555	COG2199	diguanylate cyclase activity
VAA_RS09555	COG2200	EAL domain
VAA_RS09565	COG1032	radical SAM domain protein
VAA_RS09575	COG2268	Band 7 protein
VAA_RS09585	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
VAA_RS09600	COG0300	oxidoreductase activity
VAA_RS09610	COG0501	Belongs to the peptidase M48B family
VAA_RS09615	COG1674	ftsk spoiiie
VAA_RS09620	COG1522	sequence-specific DNA binding
VAA_RS09625	COG0686	Belongs to the AlaDH PNT family
VAA_RS09635	COG0583	DNA-binding transcription factor activity
VAA_RS09650	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
VAA_RS09655	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
VAA_RS09660	COG0776	regulation of translation
VAA_RS09665	COG0539	negative regulation of cytoplasmic translation
VAA_RS09670	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
VAA_RS09675	COG1555	photosystem II stabilization
VAA_RS09680	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VAA_RS09685	COG0776	regulation of translation
VAA_RS09690	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
VAA_RS09695	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
VAA_RS09705	COG0544	peptidyl-prolyl cis-trans isomerase activity
VAA_RS09725	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VAA_RS09730	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VAA_RS09745	COG1653	transport
VAA_RS09750	COG2205	protein histidine kinase activity
VAA_RS09760	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
VAA_RS09765	COG1760	l-serine dehydratase
VAA_RS09775	COG0513	Belongs to the DEAD box helicase family
VAA_RS09785	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VAA_RS09800	COG4628	conserved protein (DUF2132)
VAA_RS09825	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VAA_RS09830	COG0583	DNA-binding transcription factor activity
VAA_RS09835	COG2951	lytic endotransglycosylase activity
VAA_RS09840	COG3100	YcgL domain-containing protein
VAA_RS09850	COG2894	cell division
VAA_RS09855	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
VAA_RS09860	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
VAA_RS09865	COG0318	PFAM AMP-dependent synthetase and ligase
VAA_RS09870	COG0596	Alpha beta hydrolase
VAA_RS09885	COG1214	PFAM Peptidase M22, glycoprotease
VAA_RS09890	COG1199	ATP-dependent helicase activity
VAA_RS09900	COG0788	formyltetrahydrofolate deformylase activity
VAA_RS09905	COG0446	pyridine nucleotide-disulphide oxidoreductase
VAA_RS09905	COG1902	pentaerythritol trinitrate reductase activity
VAA_RS09910	COG0616	signal peptide processing
VAA_RS09915	COG0252	asparaginase activity
VAA_RS09920	COG3139	Protein of unknown function (DUF1315)
VAA_RS09930	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VAA_RS09945	COG2226	methyltransferase
VAA_RS09960	COG2983	Belongs to the UPF0260 family
VAA_RS09970	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
VAA_RS09985	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
VAA_RS09990	COG2832	Protein of unknown function (DUF454)
VAA_RS10000	COG0745	RESPONSE REGULATOR receiver
VAA_RS10005	COG0583	DNA-binding transcription factor activity
VAA_RS10010	COG0778	Nitroreductase
VAA_RS10020	COG0183	Belongs to the thiolase family
VAA_RS10025	COG1595	DNA-templated transcription, initiation
VAA_RS10035	COG2067	long-chain fatty acid transport protein
VAA_RS10040	COG2067	long-chain fatty acid transport protein
VAA_RS10045	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
VAA_RS10050	COG2982	Protein involved in outer membrane biogenesis
VAA_RS10055	COG0572	uridine kinase
VAA_RS10060	COG0489	protein tyrosine kinase activity
VAA_RS10065	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VAA_RS10065	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VAA_RS10075	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
VAA_RS10085	COG0617	tRNA 3'-terminal CCA addition
VAA_RS10085	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
VAA_RS10085	COG0517	IMP dehydrogenase activity
VAA_RS10090	COG2199	diguanylate cyclase activity
VAA_RS10095	COG0314	molybdopterin synthase activity
VAA_RS10100	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
VAA_RS10110	COG0521	Mo-molybdopterin cofactor biosynthetic process
VAA_RS10115	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
VAA_RS10120	COG0391	Required for morphogenesis under gluconeogenic growth conditions
VAA_RS10125	COG2198	Histidine kinase
VAA_RS10130	COG2204	response regulator
VAA_RS10135	COG0556	nucleotide-excision repair
VAA_RS10155	COG1028	Short-chain dehydrogenase reductase Sdr
VAA_RS10160	COG1169	isochorismate synthase
VAA_RS10165	COG1021	2,3-dihydroxybenzoate-AMP ligase
VAA_RS10170	COG3433	isochorismatase activity
VAA_RS10170	COG1535	isochorismatase
VAA_RS10190	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
VAA_RS10200	COG2382	esterase
VAA_RS10205	COG4774	siderophore transport
VAA_RS10205	COG1629	transport
VAA_RS10215	COG4657	Part of a membrane complex involved in electron transport
VAA_RS10220	COG2878	Part of a membrane complex involved in electron transport
VAA_RS10225	COG4656	Part of a membrane complex involved in electron transport
VAA_RS10230	COG4658	electron transport chain
VAA_RS10235	COG4659	FMN binding
VAA_RS10240	COG4660	Part of a membrane complex involved in electron transport
VAA_RS10245	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
VAA_RS10250	COG0346	lactoylglutathione lyase activity
VAA_RS10260	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
VAA_RS10265	COG2056	Na+-H+ antiporter family
VAA_RS10270	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
VAA_RS10275	COG1286	toxin biosynthetic process
VAA_RS10280	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
VAA_RS10285	COG0285	dihydrofolate synthase activity
VAA_RS10290	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
VAA_RS10295	COG0101	tRNA pseudouridine synthase activity
VAA_RS10305	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VAA_RS10310	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VAA_RS10310	COG2190	(PTS) system
VAA_RS10310	COG1263	PTS System
VAA_RS10315	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
VAA_RS10320	COG1940	carbohydrate kinase activity
VAA_RS10320	COG1846	Transcriptional regulator
VAA_RS10325	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VAA_RS10325	COG4651	solute:proton antiporter activity
VAA_RS10330	COG0367	asparagine synthase
VAA_RS10340	COG3104	oligopeptide transport
VAA_RS10355	COG0326	Molecular chaperone. Has ATPase activity
VAA_RS10360	COG3710	Transcriptional regulator
VAA_RS10375	COG0622	Phosphoesterase
VAA_RS10380	COG1090	epimerase
VAA_RS10385	COG3118	belongs to the thioredoxin family
VAA_RS10390	COG0330	HflC and HflK could
VAA_RS10400	COG0789	Transcriptional regulator
VAA_RS10420	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
VAA_RS10425	COG3115	cell septum assembly
VAA_RS10430	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
VAA_RS10435	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
VAA_RS10440	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VAA_RS10445	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
VAA_RS10450	COG2190	(PTS) system
VAA_RS10455	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VAA_RS10460	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VAA_RS10465	COG1702	phosphate starvation-inducible protein PhoH
VAA_RS10470	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
VAA_RS10475	COG4535	Mg2 and Co2 transporter CorC
VAA_RS10480	COG0815	Transfers the fatty acyl group on membrane lipoproteins
VAA_RS10485	COG2888	peptidyl-tyrosine sulfation
VAA_RS10490	COG0495	leucyl-tRNA aminoacylation
VAA_RS10495	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
VAA_RS10500	COG1466	dna polymerase III delta subunit
VAA_RS10505	COG0799	negative regulation of ribosome biogenesis
VAA_RS10510	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
VAA_RS10515	COG0768	penicillin binding
VAA_RS10520	COG0772	Belongs to the SEDS family
VAA_RS10525	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
VAA_RS10530	COG1686	Belongs to the peptidase S11 family
VAA_RS10535	COG2921	Belongs to the UPF0250 family
VAA_RS10540	COG0321	lipoyl(octanoyl) transferase activity
VAA_RS10545	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
VAA_RS10580	COG0489	protein tyrosine kinase activity
VAA_RS10605	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
VAA_RS10615	COG1045	serine acetyltransferase
VAA_RS10655	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
VAA_RS10665	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VAA_RS10670	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VAA_RS10675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VAA_RS10715	COG2205	protein histidine kinase activity
VAA_RS10720	COG0745	RESPONSE REGULATOR receiver
VAA_RS10730	COG1263	PTS System
VAA_RS10730	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VAA_RS10745	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VAA_RS10750	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
VAA_RS10760	COG1464	Belongs to the NlpA lipoprotein family
VAA_RS10765	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
VAA_RS10790	COG1611	Belongs to the LOG family
VAA_RS10795	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VAA_RS10800	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
VAA_RS10805	COG2363	Small membrane protein
VAA_RS10810	COG0583	DNA-binding transcription factor activity
VAA_RS10815	COG0301	tRNA thio-modification
VAA_RS10815	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VAA_RS10820	COG1360	Flagellar Motor Protein
VAA_RS10820	COG1360	Flagellar Motor Protein
VAA_RS10825	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
VAA_RS10830	COG1722	exodeoxyribonuclease VII activity
VAA_RS10835	COG0142	geranyltranstransferase activity
VAA_RS10840	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
VAA_RS10845	COG0564	pseudouridine synthase activity
VAA_RS10850	COG3098	single-species biofilm formation
VAA_RS10885	COG0257	Belongs to the bacterial ribosomal protein bL36 family
VAA_RS10890	COG0254	rRNA binding
VAA_RS10895	COG1720	tRNA m6t6A37 methyltransferase activity
VAA_RS10900	COG0442	prolyl-tRNA aminoacylation
VAA_RS10905	COG2979	Protein of unknown function (DUF533)
VAA_RS10925	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
VAA_RS10925	COG0047	phosphoribosylformylglycinamidine synthase activity
VAA_RS10935	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
VAA_RS10940	COG0590	tRNA wobble adenosine to inosine editing
VAA_RS10945	COG0583	DNA-binding transcription factor activity
VAA_RS10955	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
VAA_RS10995	COG0443	Heat shock 70 kDa protein
VAA_RS11000	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
VAA_RS11005	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
VAA_RS11020	COG0497	DNA recombination
VAA_RS11025	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VAA_RS11030	COG2914	Belongs to the UPF0125 (RnfH) family
VAA_RS11035	COG2867	negative regulation of translational initiation
VAA_RS11045	COG0582	viral genome integration into host DNA
VAA_RS11050	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
VAA_RS11070	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
VAA_RS11075	COG1715	Restriction endonuclease
VAA_RS11090	COG2003	Belongs to the UPF0758 family
VAA_RS11205	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
VAA_RS11210	COG4136	ATPase activity
VAA_RS11215	COG4135	transport system, permease component
VAA_RS11220	COG4134	Bacterial extracellular solute-binding protein
VAA_RS11230	COG3313	Fe-S protein
VAA_RS11240	COG0737	Belongs to the 5'-nucleotidase family
VAA_RS11270	COG1584	GPR1 FUN34 yaaH family protein
VAA_RS11280	COG0351	phosphomethylpyrimidine kinase
VAA_RS11285	COG0518	GMP synthase (glutamine-hydrolyzing) activity
VAA_RS11285	COG0519	Catalyzes the synthesis of GMP from XMP
VAA_RS11290	COG0516	GMP reductase activity
VAA_RS11290	COG0517	IMP dehydrogenase activity
VAA_RS11305	COG1160	GTP binding
VAA_RS11310	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VAA_RS11315	COG2976	Protein conserved in bacteria
VAA_RS11320	COG0124	histidyl-tRNA synthetase
VAA_RS11325	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
VAA_RS11330	COG1426	Protein conserved in bacteria
VAA_RS11345	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VAA_RS11350	COG2975	iron-sulfur cluster assembly
VAA_RS11355	COG0633	Ferredoxin
VAA_RS11360	COG0443	Heat shock 70 kDa protein
VAA_RS11370	COG0316	Belongs to the HesB IscA family
VAA_RS11375	COG0822	iron-sulfur transferase activity
VAA_RS11385	COG1959	2 iron, 2 sulfur cluster binding
VAA_RS11390	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
VAA_RS11395	COG0483	inositol monophosphate 1-phosphatase activity
VAA_RS11400	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VAA_RS11405	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VAA_RS11410	COG1862	Preprotein translocase
VAA_RS11415	COG0343	queuine tRNA-ribosyltransferase activity
VAA_RS11425	COG0517	IMP dehydrogenase activity
VAA_RS11435	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
VAA_RS11440	COG0583	DNA-binding transcription factor activity
VAA_RS11445	COG0450	alkyl hydroperoxide reductase
VAA_RS11455	COG0704	Plays a role in the regulation of phosphate uptake
VAA_RS11460	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VAA_RS11465	COG0581	inorganic phosphate transmembrane transporter activity
VAA_RS11475	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
VAA_RS11480	COG0248	Ppx GppA phosphatase
VAA_RS11490	COG5002	protein histidine kinase activity
VAA_RS11495	COG0745	RESPONSE REGULATOR receiver
VAA_RS11505	COG0826	peptidase U32
VAA_RS11510	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VAA_RS11560	COG0542	response to heat
VAA_RS11565	COG1496	oxidoreductase activity
VAA_RS11570	COG0564	pseudouridine synthase activity
VAA_RS11575	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VAA_RS11580	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VAA_RS11585	COG1605	Chorismate mutase
VAA_RS11585	COG0077	Prephenate dehydratase
VAA_RS11590	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VAA_RS11595	COG5001	Diguanylate cyclase
VAA_RS11600	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
VAA_RS11605	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
VAA_RS11615	COG0488	(ABC) transporter
VAA_RS11625	COG1605	Chorismate mutase
VAA_RS11625	COG0287	Prephenate dehydrogenase
VAA_RS11630	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VAA_RS11635	COG3275	phosphorelay sensor kinase activity
VAA_RS11650	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
VAA_RS11655	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
VAA_RS11670	COG1966	Carbon starvation protein
VAA_RS11675	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
VAA_RS11680	COG1047	Peptidyl-prolyl cis-trans
VAA_RS11685	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
VAA_RS11695	COG0196	riboflavin kinase activity
VAA_RS11700	COG0728	peptidoglycan biosynthetic process
VAA_RS11705	COG0268	Binds directly to 16S ribosomal RNA
VAA_RS11710	COG0640	Transcriptional regulator
VAA_RS11715	COG0583	DNA-binding transcription factor activity
VAA_RS11720	COG1283	sodium-dependent phosphate transmembrane transporter activity
VAA_RS11725	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
VAA_RS11730	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
VAA_RS11765	COG2433	Pfam Transposase IS66
VAA_RS11800	COG3550	peptidyl-serine autophosphorylation
VAA_RS11815	COG3422	double-strand break repair
VAA_RS11835	COG2433	Pfam Transposase IS66
VAA_RS11845	COG2194	sulfuric ester hydrolase activity
VAA_RS11850	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
VAA_RS11875	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
VAA_RS11885	COG0730	response to heat
VAA_RS11895	COG0494	nUDIX hydrolase
VAA_RS11905	COG0667	Aldo Keto reductase
VAA_RS11915	COG2204	response regulator
VAA_RS11920	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
VAA_RS11925	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
VAA_RS11935	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
VAA_RS11940	COG0513	Belongs to the DEAD box helicase family
VAA_RS11965	COG3153	acetyltransferase
VAA_RS11970	COG3154	lipid carrier protein
VAA_RS11980	COG0826	peptidase U32
VAA_RS11985	COG0826	peptidase U32
VAA_RS11995	COG1846	Transcriptional regulator
VAA_RS12010	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
VAA_RS12015	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
VAA_RS12025	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
VAA_RS12030	COG0195	Participates in both transcription termination and antitermination
VAA_RS12035	COG0779	Required for maturation of 30S ribosomal subunits
VAA_RS12050	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VAA_RS12055	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VAA_RS12060	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
VAA_RS12065	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VAA_RS12070	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
VAA_RS12075	COG1534	Rna-binding protein
VAA_RS12080	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VAA_RS12090	COG2027	D-alanyl-D-alanine carboxypeptidase
VAA_RS12095	COG2239	Acts as a magnesium transporter
VAA_RS12105	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VAA_RS12110	COG0739	heme binding
VAA_RS12125	COG0316	Belongs to the HesB IscA family
VAA_RS12130	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
VAA_RS12135	COG0628	permease
VAA_RS12145	COG0784	Response regulator, receiver
VAA_RS12145	COG2205	protein histidine kinase activity
VAA_RS12160	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VAA_RS12165	COG0444	Belongs to the ABC transporter superfamily
VAA_RS12170	COG4608	Belongs to the ABC transporter superfamily
VAA_RS12180	COG2971	BadF BadG BcrA BcrD
VAA_RS12195	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VAA_RS12210	COG1840	ABC-type Fe3 transport system, periplasmic component
VAA_RS12215	COG0004	ammonium transporteR
VAA_RS12225	COG3112	Uncharacterised protein family (UPF0231)
VAA_RS12230	COG3835	regulator
VAA_RS12235	COG2610	gluconate transmembrane transporter activity
VAA_RS12240	COG1929	Belongs to the glycerate kinase type-1 family
VAA_RS12245	COG1049	propionate catabolic process, 2-methylcitrate cycle
VAA_RS12250	COG1752	Esterase of the alpha-beta hydrolase superfamily
VAA_RS12255	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VAA_RS12260	COG1643	Atp-dependent helicase
VAA_RS12265	COG1489	DNA binding
VAA_RS12270	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
VAA_RS12285	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VAA_RS12295	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
VAA_RS12305	COG0842	Transport permease protein
VAA_RS12310	COG1131	(ABC) transporter
VAA_RS12315	COG0659	secondary active sulfate transmembrane transporter activity
VAA_RS12320	COG0288	reversible hydration of carbon dioxide
VAA_RS12335	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VAA_RS12340	COG0508	dehydrogenase complex catalyzes the overall conversion of
VAA_RS12345	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
VAA_RS12350	COG2186	Transcriptional regulator
VAA_RS12355	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
VAA_RS12360	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VAA_RS12365	COG4974	Belongs to the 'phage' integrase family
VAA_RS12370	COG0716	FMN binding
VAA_RS12380	COG0157	Belongs to the NadC ModD family
VAA_RS12390	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VAA_RS12395	COG1459	type II secretion system
VAA_RS12405	COG0237	dephospho-CoA kinase activity
VAA_RS12410	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
VAA_RS12420	COG0335	large ribosomal subunit rRNA binding
VAA_RS12425	COG0336	Belongs to the RNA methyltransferase TrmD family
VAA_RS12430	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
VAA_RS12435	COG0228	four-way junction DNA binding
VAA_RS12440	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
VAA_RS12445	COG4137	Cytochrome C assembly protein
VAA_RS12455	COG1854	S-ribosylhomocysteine lyase activity
VAA_RS12465	COG0612	Peptidase, M16
VAA_RS12470	COG1238	metal cluster binding
VAA_RS12480	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
VAA_RS12485	COG5016	pyruvate
VAA_RS12485	COG0511	ligase activity, forming carbon-carbon bonds
VAA_RS12490	COG3630	sodium ion export across plasma membrane
VAA_RS12530	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
VAA_RS12535	COG0527	aspartate kinase activity
VAA_RS12540	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
VAA_RS12545	COG2137	regulation of response to DNA damage stimulus
VAA_RS12550	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
VAA_RS12555	COG1546	Belongs to the CinA family
VAA_RS12560	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
VAA_RS12565	COG4208	sulfate ABC transporter
VAA_RS12575	COG4150	thiosulfate binding
VAA_RS12585	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
VAA_RS12590	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VAA_RS12595	COG1388	LysM domain
VAA_RS12595	COG4942	peptidase
VAA_RS12600	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
VAA_RS12605	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
VAA_RS12610	COG0585	pseudouridine synthase activity
VAA_RS12615	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
VAA_RS12620	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
VAA_RS12625	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
VAA_RS12630	COG1968	undecaprenyl-diphosphatase activity
VAA_RS12635	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VAA_RS12640	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
VAA_RS12655	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
VAA_RS12660	COG0828	Belongs to the bacterial ribosomal protein bS21 family
VAA_RS12665	COG1610	YqeY-like protein
VAA_RS12670	COG0358	DNA primase activity
VAA_RS12690	COG3550	peptidyl-serine autophosphorylation
VAA_RS12710	COG0210	DNA helicase
VAA_RS12800	COG2801	Transposase and inactivated derivatives
VAA_RS12860	COG4584	PFAM Integrase catalytic
VAA_RS12865	COG1484	DNA-dependent DNA replication
VAA_RS13000	COG4104	PAAR repeat-containing protein
VAA_RS13005	COG3501	Rhs element vgr protein
VAA_RS13025	COG4932	domain protein
VAA_RS13025	COG5492	domain, Protein
VAA_RS13035	COG1349	DNA-binding transcription factor activity
VAA_RS13045	COG3706	GGDEF domain
VAA_RS13065	COG0668	transmembrane transport
VAA_RS13070	COG0191	fructose-bisphosphate aldolase activity
VAA_RS13075	COG0126	phosphoglycerate kinase activity
VAA_RS13080	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VAA_RS13085	COG4771	TonB-dependent receptor
VAA_RS13090	COG0583	DNA-binding transcription factor activity
VAA_RS13100	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
VAA_RS13105	COG3091	SprT-like family
VAA_RS13110	COG2356	endonuclease I
VAA_RS13115	COG1385	rRNA (uridine-N3-)-methyltransferase activity
VAA_RS13125	COG1678	Uncharacterized ACR, COG1678
VAA_RS13130	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
VAA_RS13145	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
VAA_RS13150	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
VAA_RS13155	COG0762	integral membrane protein
VAA_RS13160	COG1872	DUF167
VAA_RS13170	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
VAA_RS13175	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VAA_RS13180	COG2066	Belongs to the glutaminase family
VAA_RS13195	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
VAA_RS13200	COG0741	lytic transglycosylase activity
VAA_RS13260	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VAA_RS13265	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
VAA_RS13270	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
VAA_RS13275	COG2967	ApaG domain
VAA_RS13290	COG3610	response to peptide
VAA_RS13295	COG2966	Psort location CytoplasmicMembrane, score
VAA_RS13300	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
VAA_RS13305	COG0211	Belongs to the bacterial ribosomal protein bL27 family
VAA_RS13310	COG0261	This protein binds to 23S rRNA in the presence of protein L20
VAA_RS13315	COG0142	geranyltranstransferase activity
VAA_RS13320	COG0531	amino acid
VAA_RS13330	COG1438	arginine binding
VAA_RS13340	COG2358	TRAP transporter, solute receptor (TAXI family
VAA_RS13350	COG0589	response to stress
VAA_RS13375	COG3550	peptidyl-serine autophosphorylation
VAA_RS13390	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
VAA_RS13400	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
VAA_RS13445	COG2235	arginine
VAA_RS13450	COG0312	modulator of DNA gyrase
VAA_RS13455	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VAA_RS13460	COG3164	Protein of unknown function
VAA_RS13470	COG0424	maF-like protein
VAA_RS13475	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
VAA_RS13480	COG1792	Involved in formation and maintenance of cell shape
VAA_RS13485	COG1077	Cell shape determining protein MreB Mrl
VAA_RS13520	COG2165	general secretion pathway protein
VAA_RS13530	COG1459	type II secretion system
VAA_RS13535	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VAA_RS13545	COG3409	Peptidoglycan-binding domain 1 protein
VAA_RS13545	COG3267	Type II secretory pathway component ExeA
VAA_RS13570	COG2200	EAL domain
VAA_RS13570	COG2199	diguanylate cyclase activity
VAA_RS13575	COG0629	single-stranded DNA binding
VAA_RS13590	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
VAA_RS13600	COG2239	Acts as a magnesium transporter
VAA_RS13615	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
VAA_RS13620	COG0527	aspartate kinase activity
VAA_RS13625	COG0646	methionine synthase
VAA_RS13625	COG1410	methionine synthase
VAA_RS13665	COG0175	sulfate reduction
VAA_RS13675	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VAA_RS13695	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VAA_RS13700	COG0735	belongs to the Fur family
VAA_RS13710	COG0166	Belongs to the GPI family
VAA_RS13715	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VAA_RS13730	COG0359	binds to the 23S rRNA
VAA_RS13740	COG2965	DNA replication, synthesis of RNA primer
VAA_RS13745	COG0360	Binds together with S18 to 16S ribosomal RNA
VAA_RS13750	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VAA_RS13755	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VAA_RS13760	COG0049	tRNA binding
VAA_RS13775	COG2923	Belongs to the DsrF TusC family
VAA_RS13780	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
VAA_RS13785	COG2964	Protein conserved in bacteria
VAA_RS13790	COG0545	Peptidyl-prolyl cis-trans isomerase
VAA_RS13805	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
VAA_RS13810	COG0330	HflC and HflK could
VAA_RS13815	COG0330	HflC and HflK could
VAA_RS13820	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
VAA_RS13830	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
VAA_RS13835	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
VAA_RS13845	COG0802	atpase or kinase
VAA_RS13860	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
VAA_RS13865	COG1162	GTPase activity
VAA_RS13875	COG0490	domain, Protein
VAA_RS13875	COG0471	metal ion transport
VAA_RS13890	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
VAA_RS13895	COG4942	peptidase
VAA_RS13910	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
VAA_RS13915	COG2816	NAD+ diphosphatase activity
VAA_RS13920	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
VAA_RS13925	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
VAA_RS13930	COG0085	RNA polymerase activity
VAA_RS13935	COG0222	ribosome binding
VAA_RS13940	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
VAA_RS13955	COG0250	Participates in transcription elongation, termination and antitermination
VAA_RS13960	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VAA_RS13965	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VAA_RS13990	COG1072	(Pantothenic acid kinase))
VAA_RS13995	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
VAA_RS13995	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
VAA_RS14000	COG0812	UDP-N-acetylmuramate dehydrogenase activity
VAA_RS14010	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VAA_RS14090	COG0513	Belongs to the DEAD box helicase family
VAA_RS14120	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VAA_RS14285	COG3156	type II secretion system protein K
VAA_RS14615	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VAA_RS15070	COG0706	membrane insertase activity
VAA_RS15220	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
VAA_RS15420	COG0218	Necessary for normal cell division and for the maintenance of normal septation
VAA_RS15455	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VAA_RS15585	COG5290	Psort location Cytoplasmic, score
VAA_RS15685	COG0514	ATP-dependent DNA helicase (RecQ)
VAA_RS15710	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
VAA_RS15775	COG0612	Peptidase, M16
VAA_RS15955	COG0859	PFAM glycosyl transferase family 9
VAA_RS16250	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VAA_RS16275	COG2205	protein histidine kinase activity
VAA_RS16275	COG2202	Pas domain
VAA_RS16340	COG1288	antiporter activity
VAA_RS16485	COG0534	Mate efflux family protein
VAA_RS16510	COG0459	protein refolding
VAA_RS16640	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
VAA_RS16965	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VAA_RS17665	COG0070	glutamate synthase
VAA_RS17665	COG0069	glutamate synthase activity
VAA_RS17665	COG0067	glutamate synthase
VAA_RS17670	COG0070	glutamate synthase
VAA_RS17670	COG0069	glutamate synthase activity
VAA_RS17670	COG0067	glutamate synthase
VAA_RS17800	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
VAA_RS17880	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
VAA_RS18220	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VAA_RS18270	COG0575	Belongs to the CDS family
VAA_RS18285	COG0750	zinc metalloprotease