locus-tag	class	description
CEA93_RS00005	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CEA93_RS00015	COG0706	membrane insertase activity
CEA93_RS00035	COG1126	abc transporter atp-binding protein
CEA93_RS00055	COG0592	DNA-directed DNA polymerase activity
CEA93_RS00060	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CEA93_RS00065	COG0187	DNA topoisomerase II activity
CEA93_RS00080	COG0071	Belongs to the small heat shock protein (HSP20) family
CEA93_RS00085	COG3977	Valine--pyruvate aminotransferase
CEA93_RS00095	COG0752	glycyl-tRNA synthetase alpha subunit
CEA93_RS00100	COG2119	membrane
CEA93_RS00110	COG0425	Belongs to the sulfur carrier protein TusA family
CEA93_RS00125	COG0604	alcohol dehydrogenase
CEA93_RS00140	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CEA93_RS00145	COG3978	acetolactate synthase activity
CEA93_RS00155	COG0606	chelatase, subunit chli
CEA93_RS00230	COG2433	Pfam Transposase IS66
CEA93_RS00240	COG0606	chelatase, subunit chli
CEA93_RS00250	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CEA93_RS00255	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CEA93_RS00270	COG3084	Protein conserved in bacteria
CEA93_RS00280	COG1272	protein, Hemolysin III
CEA93_RS00290	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CEA93_RS00295	COG0569	domain protein
CEA93_RS00300	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CEA93_RS00300	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CEA93_RS00305	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CEA93_RS00310	COG0242	peptide deformylase activity
CEA93_RS00315	COG1652	LysM domain
CEA93_RS00320	COG0758	DNA mediated transformation
CEA93_RS00325	COG2922	Belongs to the Smg family
CEA93_RS00330	COG0551	DNA topoisomerase type I activity
CEA93_RS00335	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CEA93_RS00340	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CEA93_RS00345	COG0009	L-threonylcarbamoyladenylate synthase
CEA93_RS00350	COG0408	coproporphyrinogen oxidase activity
CEA93_RS00355	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CEA93_RS00365	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CEA93_RS00400	COG3071	HemY protein
CEA93_RS00405	COG2959	enzyme of heme biosynthesis
CEA93_RS00410	COG1587	Uroporphyrinogen-III synthase
CEA93_RS00435	COG0019	diaminopimelate decarboxylase activity
CEA93_RS00440	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CEA93_RS00450	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CEA93_RS00455	COG1011	Hydrolase
CEA93_RS00460	COG3148	PFAM DTW domain containing protein
CEA93_RS00470	COG0561	phosphatase activity
CEA93_RS00475	COG2267	carboxylic ester hydrolase activity
CEA93_RS00480	COG1280	lysine exporter protein (LysE YggA)
CEA93_RS00485	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
CEA93_RS00490	COG0783	Belongs to the Dps family
CEA93_RS00520	COG2095	MarC family integral membrane protein
CEA93_RS00530	COG2433	Pfam Transposase IS66
CEA93_RS00565	COG2095	MarC family integral membrane protein
CEA93_RS00575	COG0742	ribosomal rna small subunit methyltransferase
CEA93_RS00580	COG0552	protein localization to endoplasmic reticulum
CEA93_RS00585	COG2884	Cell division ATP-binding protein ftsE
CEA93_RS00590	COG2177	Part of the ABC transporter FtsEX involved in
CEA93_RS00595	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CEA93_RS00605	COG0705	Rhomboid family
CEA93_RS00610	COG1580	Controls the rotational direction of flagella during chemotaxis
CEA93_RS00615	COG3161	chorismate lyase activity
CEA93_RS00625	COG2937	Belongs to the GPAT DAPAT family
CEA93_RS00630	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CEA93_RS00640	COG0534	Mate efflux family protein
CEA93_RS00645	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CEA93_RS00660	COG3250	beta-galactosidase activity
CEA93_RS00695	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CEA93_RS00735	COG3550	peptidyl-serine autophosphorylation
CEA93_RS00780	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CEA93_RS00855	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CEA93_RS00860	COG3300	MHYT domain
CEA93_RS00860	COG5001	Diguanylate cyclase
CEA93_RS00870	COG3852	Histidine kinase
CEA93_RS00880	COG0174	glutamine synthetase
CEA93_RS00885	COG1217	gtp-binding protein TYPA
CEA93_RS00890	COG1295	ribonuclease BN
CEA93_RS00895	COG1490	D-aminoacyl-tRNA deacylase activity
CEA93_RS00900	COG0456	acetyltransferase
CEA93_RS00910	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CEA93_RS00915	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CEA93_RS00920	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CEA93_RS00925	COG3031	protein transport across the cell outer membrane
CEA93_RS00935	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CEA93_RS00940	COG1459	type II secretion system
CEA93_RS00945	COG2165	general secretion pathway protein
CEA93_RS00950	COG2165	general secretion pathway protein
CEA93_RS00955	COG2165	general secretion pathway protein
CEA93_RS00960	COG4795	General secretion pathway protein
CEA93_RS00965	COG3156	type II secretion system protein K
CEA93_RS00970	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
CEA93_RS00975	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
CEA93_RS00985	COG1218	3'(2'),5'-bisphosphate nucleotidase
CEA93_RS00990	COG0494	nUDIX hydrolase
CEA93_RS00995	COG0316	Belongs to the HesB IscA family
CEA93_RS00995	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CEA93_RS01000	COG1040	competence protein
CEA93_RS01005	COG0596	Alpha beta hydrolase
CEA93_RS01015	COG2183	response to ionizing radiation
CEA93_RS01020	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CEA93_RS01040	COG0583	DNA-binding transcription factor activity
CEA93_RS01075	COG2233	PERMEase
CEA93_RS01080	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CEA93_RS01085	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CEA93_RS01090	COG1758	RNA polymerase activity
CEA93_RS01095	COG0194	GDP metabolic process
CEA93_RS01100	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CEA93_RS01105	COG0248	Ppx GppA phosphatase
CEA93_RS01115	COG3118	belongs to the thioredoxin family
CEA93_RS01130	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CEA93_RS01175	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CEA93_RS01185	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CEA93_RS01190	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CEA93_RS01190	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CEA93_RS01195	COG1072	(Pantothenic acid kinase))
CEA93_RS01220	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CEA93_RS01225	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CEA93_RS01230	COG0250	Participates in transcription elongation, termination and antitermination
CEA93_RS01245	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CEA93_RS01250	COG0222	ribosome binding
CEA93_RS01255	COG0085	RNA polymerase activity
CEA93_RS01260	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CEA93_RS01265	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
CEA93_RS01270	COG2816	NAD+ diphosphatase activity
CEA93_RS01275	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CEA93_RS01290	COG4942	peptidase
CEA93_RS01295	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CEA93_RS01310	COG0471	metal ion transport
CEA93_RS01310	COG0490	domain, Protein
CEA93_RS01320	COG1162	GTPase activity
CEA93_RS01325	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CEA93_RS01375	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CEA93_RS01380	COG0802	atpase or kinase
CEA93_RS01390	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CEA93_RS01395	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CEA93_RS01405	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CEA93_RS01410	COG0330	HflC and HflK could
CEA93_RS01415	COG0330	HflC and HflK could
CEA93_RS01420	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
CEA93_RS01435	COG0545	Peptidyl-prolyl cis-trans isomerase
CEA93_RS01440	COG2964	Protein conserved in bacteria
CEA93_RS01445	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
CEA93_RS01450	COG2923	Belongs to the DsrF TusC family
CEA93_RS01465	COG0049	tRNA binding
CEA93_RS01470	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CEA93_RS01475	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CEA93_RS01480	COG0360	Binds together with S18 to 16S ribosomal RNA
CEA93_RS01485	COG2965	DNA replication, synthesis of RNA primer
CEA93_RS01495	COG0359	binds to the 23S rRNA
CEA93_RS01510	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CEA93_RS01515	COG0166	Belongs to the GPI family
CEA93_RS01520	COG2433	Pfam Transposase IS66
CEA93_RS01540	COG0735	belongs to the Fur family
CEA93_RS01545	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CEA93_RS01565	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CEA93_RS01575	COG0175	sulfate reduction
CEA93_RS01650	COG1410	methionine synthase
CEA93_RS01650	COG0646	methionine synthase
CEA93_RS01655	COG0527	aspartate kinase activity
CEA93_RS01660	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CEA93_RS01675	COG2239	Acts as a magnesium transporter
CEA93_RS01685	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CEA93_RS01700	COG0629	single-stranded DNA binding
CEA93_RS01705	COG2199	diguanylate cyclase activity
CEA93_RS01705	COG2200	EAL domain
CEA93_RS01730	COG3409	Peptidoglycan-binding domain 1 protein
CEA93_RS01730	COG3267	Type II secretory pathway component ExeA
CEA93_RS01740	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CEA93_RS01745	COG1459	type II secretion system
CEA93_RS01755	COG2165	general secretion pathway protein
CEA93_RS01790	COG1077	Cell shape determining protein MreB Mrl
CEA93_RS01795	COG1792	Involved in formation and maintenance of cell shape
CEA93_RS01800	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
CEA93_RS01805	COG0424	maF-like protein
CEA93_RS01815	COG3164	Protein of unknown function
CEA93_RS01820	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CEA93_RS01825	COG0312	modulator of DNA gyrase
CEA93_RS01830	COG2235	arginine
CEA93_RS01850	COG0589	response to stress
CEA93_RS01860	COG2358	TRAP transporter, solute receptor (TAXI family
CEA93_RS01870	COG1438	arginine binding
CEA93_RS01880	COG0531	amino acid
CEA93_RS01885	COG0142	geranyltranstransferase activity
CEA93_RS01895	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CEA93_RS01900	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CEA93_RS01905	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CEA93_RS01910	COG2966	Psort location CytoplasmicMembrane, score
CEA93_RS01915	COG3610	response to peptide
CEA93_RS01930	COG2967	ApaG domain
CEA93_RS01935	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CEA93_RS01940	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CEA93_RS01945	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CEA93_RS01950	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CEA93_RS01955	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CEA93_RS02005	COG0741	lytic transglycosylase activity
CEA93_RS02010	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
CEA93_RS02025	COG2066	Belongs to the glutaminase family
CEA93_RS02030	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CEA93_RS02035	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CEA93_RS02045	COG1872	DUF167
CEA93_RS02050	COG0762	integral membrane protein
CEA93_RS02055	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CEA93_RS02060	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CEA93_RS02075	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CEA93_RS02080	COG1678	Uncharacterized ACR, COG1678
CEA93_RS02090	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CEA93_RS02095	COG2356	endonuclease I
CEA93_RS02100	COG3091	SprT-like family
CEA93_RS02105	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CEA93_RS02110	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CEA93_RS02115	COG0583	DNA-binding transcription factor activity
CEA93_RS02120	COG4771	TonB-dependent receptor
CEA93_RS02125	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CEA93_RS02130	COG0126	phosphoglycerate kinase activity
CEA93_RS02140	COG0191	fructose-bisphosphate aldolase activity
CEA93_RS02145	COG0668	transmembrane transport
CEA93_RS02165	COG3706	GGDEF domain
CEA93_RS02175	COG1349	DNA-binding transcription factor activity
CEA93_RS02185	COG4932	domain protein
CEA93_RS02185	COG5492	domain, Protein
CEA93_RS02205	COG3501	Rhs element vgr protein
CEA93_RS02210	COG4104	PAAR repeat-containing protein
CEA93_RS02355	COG1484	DNA-dependent DNA replication
CEA93_RS02360	COG4584	PFAM Integrase catalytic
CEA93_RS02515	COG0210	DNA helicase
CEA93_RS02535	COG3550	peptidyl-serine autophosphorylation
CEA93_RS02555	COG0358	DNA primase activity
CEA93_RS02560	COG1610	YqeY-like protein
CEA93_RS02565	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CEA93_RS02570	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CEA93_RS02585	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CEA93_RS02590	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CEA93_RS02595	COG1968	undecaprenyl-diphosphatase activity
CEA93_RS02600	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CEA93_RS02605	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CEA93_RS02610	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CEA93_RS02615	COG0585	pseudouridine synthase activity
CEA93_RS02620	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CEA93_RS02625	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CEA93_RS02630	COG1388	LysM domain
CEA93_RS02630	COG4942	peptidase
CEA93_RS02635	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CEA93_RS02640	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CEA93_RS02650	COG4150	thiosulfate binding
CEA93_RS02660	COG4208	sulfate ABC transporter
CEA93_RS02665	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CEA93_RS02670	COG1546	Belongs to the CinA family
CEA93_RS02675	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CEA93_RS02680	COG2137	regulation of response to DNA damage stimulus
CEA93_RS02685	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CEA93_RS02690	COG0527	aspartate kinase activity
CEA93_RS02695	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CEA93_RS02735	COG3630	sodium ion export across plasma membrane
CEA93_RS02740	COG5016	pyruvate
CEA93_RS02740	COG0511	ligase activity, forming carbon-carbon bonds
CEA93_RS02745	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
CEA93_RS02755	COG1238	metal cluster binding
CEA93_RS02760	COG0612	Peptidase, M16
CEA93_RS02770	COG1854	S-ribosylhomocysteine lyase activity
CEA93_RS02775	COG4536	flavin adenine dinucleotide binding
CEA93_RS02780	COG4137	Cytochrome C assembly protein
CEA93_RS02785	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CEA93_RS02790	COG0228	four-way junction DNA binding
CEA93_RS02795	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CEA93_RS02800	COG0336	Belongs to the RNA methyltransferase TrmD family
CEA93_RS02805	COG0335	large ribosomal subunit rRNA binding
CEA93_RS02815	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
CEA93_RS02820	COG0237	dephospho-CoA kinase activity
CEA93_RS02830	COG1459	type II secretion system
CEA93_RS02835	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CEA93_RS02845	COG0157	Belongs to the NadC ModD family
CEA93_RS02855	COG0716	FMN binding
CEA93_RS02860	COG4974	Belongs to the 'phage' integrase family
CEA93_RS02865	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CEA93_RS02870	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CEA93_RS02875	COG2186	Transcriptional regulator
CEA93_RS02880	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CEA93_RS02885	COG0508	dehydrogenase complex catalyzes the overall conversion of
CEA93_RS02890	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CEA93_RS02905	COG0288	reversible hydration of carbon dioxide
CEA93_RS02910	COG0659	secondary active sulfate transmembrane transporter activity
CEA93_RS02915	COG1131	(ABC) transporter
CEA93_RS02920	COG0842	Transport permease protein
CEA93_RS02930	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CEA93_RS02940	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CEA93_RS02950	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CEA93_RS02955	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CEA93_RS02960	COG1489	DNA binding
CEA93_RS02965	COG1643	Atp-dependent helicase
CEA93_RS02970	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CEA93_RS02975	COG1752	Esterase of the alpha-beta hydrolase superfamily
CEA93_RS02980	COG1049	propionate catabolic process, 2-methylcitrate cycle
CEA93_RS02985	COG1929	Belongs to the glycerate kinase type-1 family
CEA93_RS02990	COG2610	gluconate transmembrane transporter activity
CEA93_RS02995	COG3835	regulator
CEA93_RS03000	COG3112	Uncharacterised protein family (UPF0231)
CEA93_RS03010	COG0004	ammonium transporteR
CEA93_RS03015	COG1840	ABC-type Fe3 transport system, periplasmic component
CEA93_RS03030	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CEA93_RS03045	COG2971	BadF BadG BcrA BcrD
CEA93_RS03055	COG4608	Belongs to the ABC transporter superfamily
CEA93_RS03060	COG0444	Belongs to the ABC transporter superfamily
CEA93_RS03065	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CEA93_RS03080	COG0784	Response regulator, receiver
CEA93_RS03080	COG2205	protein histidine kinase activity
CEA93_RS03090	COG0628	permease
CEA93_RS03095	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CEA93_RS03100	COG0316	Belongs to the HesB IscA family
CEA93_RS03115	COG0739	heme binding
CEA93_RS03120	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CEA93_RS03130	COG2239	Acts as a magnesium transporter
CEA93_RS03135	COG2027	D-alanyl-D-alanine carboxypeptidase
CEA93_RS03145	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CEA93_RS03150	COG1534	Rna-binding protein
CEA93_RS03155	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CEA93_RS03160	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CEA93_RS03165	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CEA93_RS03170	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CEA93_RS03175	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CEA93_RS03190	COG0779	Required for maturation of 30S ribosomal subunits
CEA93_RS03195	COG0195	Participates in both transcription termination and antitermination
CEA93_RS03200	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CEA93_RS03210	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CEA93_RS03215	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CEA93_RS03230	COG1846	Transcriptional regulator
CEA93_RS03240	COG0826	peptidase U32
CEA93_RS03245	COG0826	peptidase U32
CEA93_RS03260	COG3153	acetyltransferase
CEA93_RS03285	COG0513	Belongs to the DEAD box helicase family
CEA93_RS03290	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CEA93_RS03305	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CEA93_RS03310	COG2204	response regulator
CEA93_RS03320	COG0667	Aldo Keto reductase
CEA93_RS03330	COG0494	nUDIX hydrolase
CEA93_RS03340	COG0730	response to heat
CEA93_RS03350	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CEA93_RS03375	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CEA93_RS03380	COG2194	sulfuric ester hydrolase activity
CEA93_RS03390	COG2433	Pfam Transposase IS66
CEA93_RS03410	COG3422	double-strand break repair
CEA93_RS03425	COG3550	peptidyl-serine autophosphorylation
CEA93_RS03465	COG2433	Pfam Transposase IS66
CEA93_RS03495	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CEA93_RS03500	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CEA93_RS03505	COG1283	sodium-dependent phosphate transmembrane transporter activity
CEA93_RS03510	COG0583	DNA-binding transcription factor activity
CEA93_RS03515	COG0640	Transcriptional regulator
CEA93_RS03520	COG0268	Binds directly to 16S ribosomal RNA
CEA93_RS03525	COG0728	peptidoglycan biosynthetic process
CEA93_RS03530	COG0196	riboflavin kinase activity
CEA93_RS03540	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CEA93_RS03545	COG1047	Peptidyl-prolyl cis-trans
CEA93_RS03550	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CEA93_RS03555	COG1966	Carbon starvation protein
CEA93_RS03570	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CEA93_RS03575	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CEA93_RS03585	COG3279	Response regulator of the LytR AlgR family
CEA93_RS03590	COG3275	phosphorelay sensor kinase activity
CEA93_RS03595	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CEA93_RS03600	COG0287	Prephenate dehydrogenase
CEA93_RS03600	COG1605	Chorismate mutase
CEA93_RS03610	COG0488	(ABC) transporter
CEA93_RS03620	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
CEA93_RS03625	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
CEA93_RS03630	COG5001	Diguanylate cyclase
CEA93_RS03635	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CEA93_RS03640	COG1605	Chorismate mutase
CEA93_RS03640	COG0077	Prephenate dehydratase
CEA93_RS03645	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CEA93_RS03650	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CEA93_RS03655	COG0564	pseudouridine synthase activity
CEA93_RS03660	COG1496	oxidoreductase activity
CEA93_RS03665	COG0542	response to heat
CEA93_RS03710	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CEA93_RS03715	COG0826	peptidase U32
CEA93_RS03725	COG0745	RESPONSE REGULATOR receiver
CEA93_RS03730	COG5002	protein histidine kinase activity
CEA93_RS03740	COG0248	Ppx GppA phosphatase
CEA93_RS03745	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CEA93_RS03755	COG0581	inorganic phosphate transmembrane transporter activity
CEA93_RS03760	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CEA93_RS03765	COG0704	Plays a role in the regulation of phosphate uptake
CEA93_RS03775	COG0450	alkyl hydroperoxide reductase
CEA93_RS03780	COG0583	DNA-binding transcription factor activity
CEA93_RS03785	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CEA93_RS03795	COG0517	IMP dehydrogenase activity
CEA93_RS03805	COG0343	queuine tRNA-ribosyltransferase activity
CEA93_RS03810	COG1862	Preprotein translocase
CEA93_RS03815	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CEA93_RS03820	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CEA93_RS03825	COG0483	inositol monophosphate 1-phosphatase activity
CEA93_RS03830	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
CEA93_RS03835	COG1959	2 iron, 2 sulfur cluster binding
CEA93_RS03845	COG0822	iron-sulfur transferase activity
CEA93_RS03850	COG0316	Belongs to the HesB IscA family
CEA93_RS03860	COG0443	Heat shock 70 kDa protein
CEA93_RS03865	COG0633	Ferredoxin
CEA93_RS03870	COG2975	iron-sulfur cluster assembly
CEA93_RS03875	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CEA93_RS03890	COG1426	Protein conserved in bacteria
CEA93_RS03895	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CEA93_RS03900	COG0124	histidyl-tRNA synthetase
CEA93_RS03905	COG2976	Protein conserved in bacteria
CEA93_RS03910	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CEA93_RS03915	COG1160	GTP binding
CEA93_RS03930	COG0516	GMP reductase activity
CEA93_RS03930	COG0517	IMP dehydrogenase activity
CEA93_RS03935	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CEA93_RS03935	COG0519	Catalyzes the synthesis of GMP from XMP
CEA93_RS03940	COG0351	phosphomethylpyrimidine kinase
CEA93_RS03950	COG1584	GPR1 FUN34 yaaH family protein
CEA93_RS03955	COG1115	amino acid carrier protein
CEA93_RS03985	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CEA93_RS03985	COG3711	transcriptional antiterminator
CEA93_RS04000	COG3964	amidohydrolase
CEA93_RS04030	COG0556	nucleotide-excision repair
CEA93_RS04155	COG2003	Belongs to the UPF0758 family
CEA93_RS04170	COG1715	Restriction endonuclease
CEA93_RS04175	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
CEA93_RS04195	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CEA93_RS04200	COG0582	viral genome integration into host DNA
CEA93_RS04215	COG2867	negative regulation of translational initiation
CEA93_RS04220	COG2914	Belongs to the UPF0125 (RnfH) family
CEA93_RS04225	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CEA93_RS04230	COG0497	DNA recombination
CEA93_RS04235	COG3033	Beta-eliminating lyase
CEA93_RS04240	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CEA93_RS04245	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CEA93_RS04250	COG0443	Heat shock 70 kDa protein
CEA93_RS04255	COG0484	heat shock protein binding
CEA93_RS04285	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CEA93_RS04290	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CEA93_RS04300	COG0583	DNA-binding transcription factor activity
CEA93_RS04305	COG0590	tRNA wobble adenosine to inosine editing
CEA93_RS04310	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CEA93_RS04320	COG0047	phosphoribosylformylglycinamidine synthase activity
CEA93_RS04320	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CEA93_RS04340	COG2979	Protein of unknown function (DUF533)
CEA93_RS04345	COG0442	prolyl-tRNA aminoacylation
CEA93_RS04350	COG1720	tRNA m6t6A37 methyltransferase activity
CEA93_RS04355	COG0254	rRNA binding
CEA93_RS04360	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CEA93_RS04390	COG3098	single-species biofilm formation
CEA93_RS04395	COG0564	pseudouridine synthase activity
CEA93_RS04400	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CEA93_RS04405	COG0142	geranyltranstransferase activity
CEA93_RS04410	COG1722	exodeoxyribonuclease VII activity
CEA93_RS04415	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CEA93_RS04425	COG0301	tRNA thio-modification
CEA93_RS04425	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CEA93_RS04430	COG0583	DNA-binding transcription factor activity
CEA93_RS04435	COG2363	Small membrane protein
CEA93_RS04440	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
CEA93_RS04445	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CEA93_RS04450	COG1611	Belongs to the LOG family
CEA93_RS04475	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
CEA93_RS04480	COG1464	Belongs to the NlpA lipoprotein family
CEA93_RS04485	COG2011	ABC-type metal ion transport system permease component
CEA93_RS04490	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CEA93_RS04495	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CEA93_RS04510	COG1263	PTS System
CEA93_RS04510	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CEA93_RS04515	COG0366	Alpha amylase catalytic
CEA93_RS04520	COG0745	RESPONSE REGULATOR receiver
CEA93_RS04525	COG2205	protein histidine kinase activity
CEA93_RS04560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CEA93_RS04565	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CEA93_RS04570	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CEA93_RS04575	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CEA93_RS04580	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CEA93_RS04620	COG1045	serine acetyltransferase
CEA93_RS04630	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
CEA93_RS04660	COG0489	protein tyrosine kinase activity
CEA93_RS04665	COG1596	polysaccharide export
CEA93_RS04695	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CEA93_RS04700	COG0321	lipoyl(octanoyl) transferase activity
CEA93_RS04705	COG2921	Belongs to the UPF0250 family
CEA93_RS04710	COG1686	Belongs to the peptidase S11 family
CEA93_RS04715	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CEA93_RS04720	COG0772	Belongs to the SEDS family
CEA93_RS04725	COG0768	penicillin binding
CEA93_RS04730	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CEA93_RS04735	COG0799	negative regulation of ribosome biogenesis
CEA93_RS04740	COG1466	dna polymerase III delta subunit
CEA93_RS04745	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
CEA93_RS04750	COG0495	leucyl-tRNA aminoacylation
CEA93_RS04755	COG2888	peptidyl-tyrosine sulfation
CEA93_RS04760	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CEA93_RS04765	COG4535	Mg2 and Co2 transporter CorC
CEA93_RS04770	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CEA93_RS04775	COG1702	phosphate starvation-inducible protein PhoH
CEA93_RS04780	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CEA93_RS04785	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CEA93_RS04790	COG2190	(PTS) system
CEA93_RS04795	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CEA93_RS04800	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CEA93_RS04805	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CEA93_RS04810	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
CEA93_RS04815	COG3115	cell septum assembly
CEA93_RS04820	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CEA93_RS04840	COG0789	Transcriptional regulator
CEA93_RS04850	COG0330	HflC and HflK could
CEA93_RS04855	COG3118	belongs to the thioredoxin family
CEA93_RS04860	COG1090	epimerase
CEA93_RS04865	COG0622	Phosphoesterase
CEA93_RS04880	COG3710	Transcriptional regulator
CEA93_RS04885	COG0326	Molecular chaperone. Has ATPase activity
CEA93_RS04895	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CEA93_RS04900	COG3104	oligopeptide transport
CEA93_RS04910	COG0367	asparagine synthase
CEA93_RS04915	COG4651	solute:proton antiporter activity
CEA93_RS04915	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CEA93_RS04920	COG1846	Transcriptional regulator
CEA93_RS04920	COG1940	carbohydrate kinase activity
CEA93_RS04925	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CEA93_RS04930	COG2190	(PTS) system
CEA93_RS04930	COG1263	PTS System
CEA93_RS04930	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CEA93_RS04935	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CEA93_RS04945	COG0101	tRNA pseudouridine synthase activity
CEA93_RS04950	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CEA93_RS04955	COG0285	dihydrofolate synthase activity
CEA93_RS04960	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
CEA93_RS04965	COG1286	toxin biosynthetic process
CEA93_RS04970	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CEA93_RS04975	COG2056	Na+-H+ antiporter family
CEA93_RS04980	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CEA93_RS04990	COG0346	lactoylglutathione lyase activity
CEA93_RS04995	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CEA93_RS05000	COG4660	Part of a membrane complex involved in electron transport
CEA93_RS05005	COG4659	FMN binding
CEA93_RS05010	COG4658	electron transport chain
CEA93_RS05015	COG4656	Part of a membrane complex involved in electron transport
CEA93_RS05020	COG2878	Part of a membrane complex involved in electron transport
CEA93_RS05025	COG4657	Part of a membrane complex involved in electron transport
CEA93_RS05035	COG1629	transport
CEA93_RS05035	COG4774	siderophore transport
CEA93_RS05040	COG2382	esterase
CEA93_RS05050	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CEA93_RS05070	COG1535	isochorismatase
CEA93_RS05070	COG3433	isochorismatase activity
CEA93_RS05075	COG1021	2,3-dihydroxybenzoate-AMP ligase
CEA93_RS05080	COG1169	isochorismate synthase
CEA93_RS05085	COG1028	Short-chain dehydrogenase reductase Sdr
CEA93_RS05090	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CEA93_RS05105	COG0556	nucleotide-excision repair
CEA93_RS05110	COG2204	response regulator
CEA93_RS05115	COG2198	Histidine kinase
CEA93_RS05120	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CEA93_RS05125	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CEA93_RS05130	COG0521	Mo-molybdopterin cofactor biosynthetic process
CEA93_RS05140	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CEA93_RS05145	COG0314	molybdopterin synthase activity
CEA93_RS05150	COG2199	diguanylate cyclase activity
CEA93_RS05155	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CEA93_RS05155	COG0617	tRNA 3'-terminal CCA addition
CEA93_RS05155	COG0517	IMP dehydrogenase activity
CEA93_RS05165	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
CEA93_RS05175	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CEA93_RS05175	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CEA93_RS05180	COG0489	protein tyrosine kinase activity
CEA93_RS05185	COG0572	uridine kinase
CEA93_RS05190	COG2982	Protein involved in outer membrane biogenesis
CEA93_RS05195	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
CEA93_RS05200	COG2067	long-chain fatty acid transport protein
CEA93_RS05205	COG2067	long-chain fatty acid transport protein
CEA93_RS05215	COG1595	DNA-templated transcription, initiation
CEA93_RS05230	COG0183	Belongs to the thiolase family
CEA93_RS05235	COG1024	Enoyl-CoA hydratase
CEA93_RS05235	COG1250	3-hydroxyacyl-CoA dehydrogenase
CEA93_RS05240	COG0778	Nitroreductase
CEA93_RS05245	COG0583	DNA-binding transcription factor activity
CEA93_RS05250	COG0745	RESPONSE REGULATOR receiver
CEA93_RS05260	COG2832	Protein of unknown function (DUF454)
CEA93_RS05265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CEA93_RS05280	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CEA93_RS05290	COG2983	Belongs to the UPF0260 family
CEA93_RS05305	COG2226	methyltransferase
CEA93_RS05320	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CEA93_RS05330	COG3139	Protein of unknown function (DUF1315)
CEA93_RS05335	COG0252	asparaginase activity
CEA93_RS05340	COG0616	signal peptide processing
CEA93_RS05345	COG0446	pyridine nucleotide-disulphide oxidoreductase
CEA93_RS05345	COG1902	pentaerythritol trinitrate reductase activity
CEA93_RS05350	COG0788	formyltetrahydrofolate deformylase activity
CEA93_RS05360	COG1199	ATP-dependent helicase activity
CEA93_RS05365	COG1214	PFAM Peptidase M22, glycoprotease
CEA93_RS05380	COG0596	Alpha beta hydrolase
CEA93_RS05385	COG0318	PFAM AMP-dependent synthetase and ligase
CEA93_RS05390	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CEA93_RS05395	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CEA93_RS05400	COG2894	cell division
CEA93_RS05410	COG3100	YcgL domain-containing protein
CEA93_RS05415	COG2951	lytic endotransglycosylase activity
CEA93_RS05420	COG0583	DNA-binding transcription factor activity
CEA93_RS05425	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CEA93_RS05450	COG4628	conserved protein (DUF2132)
CEA93_RS05465	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CEA93_RS05475	COG0513	Belongs to the DEAD box helicase family
CEA93_RS05485	COG1760	l-serine dehydratase
CEA93_RS05490	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CEA93_RS05500	COG2205	protein histidine kinase activity
CEA93_RS05505	COG1653	transport
CEA93_RS05515	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CEA93_RS05520	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CEA93_RS05525	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CEA93_RS05545	COG0544	peptidyl-prolyl cis-trans isomerase activity
CEA93_RS05555	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CEA93_RS05560	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CEA93_RS05565	COG0776	regulation of translation
CEA93_RS05570	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CEA93_RS05575	COG1555	photosystem II stabilization
CEA93_RS05580	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CEA93_RS05585	COG0539	negative regulation of cytoplasmic translation
CEA93_RS05590	COG0776	regulation of translation
CEA93_RS05595	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
CEA93_RS05600	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CEA93_RS05615	COG0583	DNA-binding transcription factor activity
CEA93_RS05625	COG0686	Belongs to the AlaDH PNT family
CEA93_RS05630	COG1522	sequence-specific DNA binding
CEA93_RS05635	COG1674	ftsk spoiiie
CEA93_RS05645	COG0501	Belongs to the peptidase M48B family
CEA93_RS05655	COG0300	oxidoreductase activity
CEA93_RS05670	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CEA93_RS05680	COG2268	Band 7 protein
CEA93_RS05690	COG1032	radical SAM domain protein
CEA93_RS05700	COG2200	EAL domain
CEA93_RS05700	COG2199	diguanylate cyclase activity
CEA93_RS05700	COG2203	Gaf domain
CEA93_RS05715	COG0583	DNA-binding transcription factor activity
CEA93_RS05720	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CEA93_RS05730	COG2350	Protein conserved in bacteria
CEA93_RS05760	COG0159	tryptophan synthase activity
CEA93_RS05765	COG0133	tryptophan synthase activity
CEA93_RS05770	COG0134	indole-3-glycerol-phosphate synthase activity
CEA93_RS05770	COG0135	phosphoribosylanthranilate isomerase activity
CEA93_RS05775	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CEA93_RS05780	COG0512	Glutamine amidotransferase of anthranilate synthase
CEA93_RS05785	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CEA93_RS05795	COG0613	PHP domain protein
CEA93_RS05800	COG0009	L-threonylcarbamoyladenylate synthase
CEA93_RS05805	COG1187	pseudouridine synthase activity
CEA93_RS05820	COG1595	DNA-templated transcription, initiation
CEA93_RS05835	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CEA93_RS05840	COG4988	ABC transporter
CEA93_RS05845	COG0492	ferredoxin-NADP+ reductase activity
CEA93_RS05865	COG2949	membrane
CEA93_RS05875	COG0281	malic enzyme
CEA93_RS05885	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CEA93_RS05890	COG3273	potassium ion transport
CEA93_RS05890	COG2985	domain, Protein
CEA93_RS05895	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CEA93_RS05905	COG1737	Transcriptional regulator
CEA93_RS05910	COG0076	glutamate decarboxylase activity
CEA93_RS05920	COG2431	L-lysine efflux transmembrane transporter activity
CEA93_RS05930	COG3070	regulator of competence-specific genes
CEA93_RS05945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CEA93_RS05945	COG4191	Histidine kinase
CEA93_RS05955	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CEA93_RS05960	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CEA93_RS05965	COG2915	High frequency lysogenization protein hflD homolog
CEA93_RS05970	COG0482	sulfurtransferase activity
CEA93_RS05980	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CEA93_RS05985	COG2916	Histone family protein nucleoid-structuring protein H-NS
CEA93_RS05990	COG1757	Na H antiporter
CEA93_RS05995	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CEA93_RS06000	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CEA93_RS06005	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CEA93_RS06010	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CEA93_RS06010	COG0131	Imidazoleglycerol-phosphate dehydratase
CEA93_RS06015	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CEA93_RS06020	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CEA93_RS06025	COG0107	imidazoleglycerol-phosphate synthase activity
CEA93_RS06030	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CEA93_RS06030	COG0140	phosphoribosyl-ATP diphosphatase activity
CEA93_RS06035	COG1187	pseudouridine synthase activity
CEA93_RS06045	COG1278	Cold shock
CEA93_RS06050	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CEA93_RS06055	COG0542	response to heat
CEA93_RS06060	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CEA93_RS06065	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
CEA93_RS06070	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CEA93_RS06085	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CEA93_RS06090	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CEA93_RS06095	COG0297	glycogen (starch) synthase activity
CEA93_RS06115	COG3070	regulator of competence-specific genes
CEA93_RS06120	COG1609	Transcriptional regulator
CEA93_RS06130	COG0745	RESPONSE REGULATOR receiver
CEA93_RS06135	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CEA93_RS06140	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CEA93_RS06150	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
CEA93_RS06155	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
CEA93_RS06170	COG0189	ligase activity
CEA93_RS06170	COG4067	protein conserved in archaea
CEA93_RS06175	COG0500	methyltransferase
CEA93_RS06180	COG4106	trans-aconitate 2-methyltransferase activity
CEA93_RS06190	COG1801	Protein of unknown function DUF72
CEA93_RS06195	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CEA93_RS06200	COG1435	thymidine kinase activity
CEA93_RS06205	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CEA93_RS06230	COG2116	formate transmembrane transporter activity
CEA93_RS06235	COG4459	periplasmic nitrate reductase
CEA93_RS06240	COG3005	denitrification pathway
CEA93_RS06245	COG0243	molybdopterin cofactor binding
CEA93_RS06255	COG1227	inorganic diphosphatase activity
CEA93_RS06270	COG4172	Belongs to the ABC transporter superfamily
CEA93_RS06280	COG4171	peptide transport system, permease
CEA93_RS06295	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CEA93_RS06300	COG1842	Phage shock protein A
CEA93_RS06315	COG0519	Catalyzes the synthesis of GMP from XMP
CEA93_RS06320	COG0626	cystathionine gamma-synthase activity
CEA93_RS06330	COG0733	neurotransmitter:sodium symporter activity
CEA93_RS06335	COG0564	pseudouridine synthase activity
CEA93_RS06350	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CEA93_RS06355	COG4136	ATPase activity
CEA93_RS06360	COG4135	transport system, permease component
CEA93_RS06365	COG4134	Bacterial extracellular solute-binding protein
CEA93_RS06375	COG3313	Fe-S protein
CEA93_RS06385	COG0737	Belongs to the 5'-nucleotidase family
CEA93_RS06405	COG0513	Belongs to the DEAD box helicase family
CEA93_RS06420	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CEA93_RS06425	COG2205	protein histidine kinase activity
CEA93_RS06440	COG1061	Type III restriction enzyme res subunit
CEA93_RS06445	COG1187	pseudouridine synthase activity
CEA93_RS06450	COG2814	Major facilitator Superfamily
CEA93_RS06460	COG0702	epimerase
CEA93_RS06465	COG0534	Mate efflux family protein
CEA93_RS06470	COG4181	ATPase activity
CEA93_RS06485	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CEA93_RS06510	COG0840	transmembrane signaling receptor activity
CEA93_RS06540	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CEA93_RS06545	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CEA93_RS06550	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CEA93_RS06560	COG0840	transmembrane signaling receptor activity
CEA93_RS06580	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
CEA93_RS06595	COG5016	pyruvate
CEA93_RS06595	COG0511	ligase activity, forming carbon-carbon bonds
CEA93_RS06600	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
CEA93_RS06610	COG4565	transcriptional regulatory protein
CEA93_RS06620	COG2301	Belongs to the HpcH HpaI aldolase family
CEA93_RS06625	COG3051	citrate lyase alpha subunit
CEA93_RS06635	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
CEA93_RS06660	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CEA93_RS06660	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CEA93_RS06660	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CEA93_RS06665	COG2207	Transcriptional regulator
CEA93_RS06675	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CEA93_RS06685	COG1342	Belongs to the UPF0251 family
CEA93_RS06705	COG1129	ABC transporter
CEA93_RS06720	COG1902	pentaerythritol trinitrate reductase activity
CEA93_RS06725	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CEA93_RS06730	COG5002	protein histidine kinase activity
CEA93_RS06735	COG0745	RESPONSE REGULATOR receiver
CEA93_RS06765	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CEA93_RS06770	COG0372	Belongs to the citrate synthase family
CEA93_RS06775	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CEA93_RS06780	COG2828	Protein conserved in bacteria
CEA93_RS06800	COG0561	phosphatase activity
CEA93_RS06805	COG0602	queuosine metabolic process
CEA93_RS06835	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CEA93_RS06845	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CEA93_RS06850	COG1254	Belongs to the acylphosphatase family
CEA93_RS06855	COG2920	part of a sulfur-relay system
CEA93_RS06860	COG0670	Belongs to the BI1 family
CEA93_RS06865	COG1126	abc transporter atp-binding protein
CEA93_RS06870	COG0765	amino acid transport
CEA93_RS06875	COG4597	amino acid ABC transporter
CEA93_RS06880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CEA93_RS06885	COG1648	precorrin-2 dehydrogenase activity
CEA93_RS06885	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CEA93_RS06895	COG1666	GTP binding
CEA93_RS06900	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CEA93_RS06920	COG2996	Protein conserved in bacteria
CEA93_RS06930	COG3008	intermembrane lipid transfer
CEA93_RS06935	COG2995	paraquat-inducible protein a
CEA93_RS06940	COG1132	(ABC) transporter
CEA93_RS06945	COG1956	GAF domain-containing protein
CEA93_RS06950	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
CEA93_RS06965	COG0308	aminopeptidase N
CEA93_RS06975	COG2902	Dehydrogenase
CEA93_RS06980	COG0167	dihydroorotate dehydrogenase activity
CEA93_RS07000	COG0488	(ABC) transporter
CEA93_RS07015	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CEA93_RS07020	COG1067	ATP-dependent peptidase activity
CEA93_RS07025	COG3120	sequence-specific DNA binding
CEA93_RS07055	COG3278	Belongs to the heme-copper respiratory oxidase family
CEA93_RS07070	COG2010	Cytochrome c
CEA93_RS07080	COG2217	Heavy metal translocating P-type atpase
CEA93_RS07095	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CEA93_RS07100	COG0589	response to stress
CEA93_RS07125	COG3842	ATPase activity
CEA93_RS07130	COG1176	ABC-type spermidine putrescine transport system, permease component I
CEA93_RS07135	COG1177	transmembrane transport
CEA93_RS07140	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CEA93_RS07150	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CEA93_RS07155	COG0004	ammonium transporteR
CEA93_RS07160	COG0488	(ABC) transporter
CEA93_RS07165	COG2197	response regulator
CEA93_RS07175	COG2271	Major facilitator Superfamily
CEA93_RS07180	COG1840	ABC-type Fe3 transport system, periplasmic component
CEA93_RS07190	COG3842	ATPase activity
CEA93_RS07195	COG0746	molybdenum cofactor guanylyltransferase activity
CEA93_RS07200	COG1763	Mo-molybdopterin cofactor biosynthetic process
CEA93_RS07210	COG1940	carbohydrate kinase activity
CEA93_RS07215	COG3148	PFAM DTW domain containing protein
CEA93_RS07225	COG0840	transmembrane signaling receptor activity
CEA93_RS07230	COG0791	NLP P60 protein
CEA93_RS07240	COG3001	Fructosamine kinase
CEA93_RS07255	COG1793	dna ligase
CEA93_RS07260	COG4667	esterase of the alpha-beta hydrolase superfamily
CEA93_RS07275	COG0848	biopolymer transport protein
CEA93_RS07280	COG0811	peptide transport
CEA93_RS07285	COG0811	peptide transport
CEA93_RS07315	COG0625	glutathione transferase activity
CEA93_RS07325	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
CEA93_RS07335	COG2195	Cleaves the N-terminal amino acid of tripeptides
CEA93_RS07350	COG1115	amino acid carrier protein
CEA93_RS07355	COG1280	lysine exporter protein (LysE YggA)
CEA93_RS07360	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CEA93_RS07370	COG2433	Pfam Transposase IS66
CEA93_RS07390	COG1204	response to ionizing radiation
CEA93_RS07405	COG2433	Pfam Transposase IS66
CEA93_RS07445	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CEA93_RS07450	COG0673	inositol 2-dehydrogenase activity
CEA93_RS07475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CEA93_RS07480	COG3962	Belongs to the TPP enzyme family
CEA93_RS07485	COG3718	enzyme involved in inositol metabolism
CEA93_RS07495	COG2176	DNA-directed DNA polymerase activity
CEA93_RS07500	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CEA93_RS07500	COG0517	IMP dehydrogenase activity
CEA93_RS07505	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CEA93_RS07510	COG0673	inositol 2-dehydrogenase activity
CEA93_RS07525	COG0477	Major facilitator Superfamily
CEA93_RS07530	COG0583	DNA-binding transcription factor activity
CEA93_RS07540	COG1643	Atp-dependent helicase
CEA93_RS07560	COG5002	protein histidine kinase activity
CEA93_RS07560	COG5001	Diguanylate cyclase
CEA93_RS07610	COG1609	Transcriptional regulator
CEA93_RS07615	COG2723	6-phospho-beta-galactosidase activity
CEA93_RS07620	COG0513	Belongs to the DEAD box helicase family
CEA93_RS07625	COG0243	molybdopterin cofactor binding
CEA93_RS07630	COG3005	denitrification pathway
CEA93_RS07635	COG1278	Cold shock
CEA93_RS07650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CEA93_RS07650	COG4191	Histidine kinase
CEA93_RS07655	COG0471	metal ion transport
CEA93_RS07665	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CEA93_RS07685	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CEA93_RS07695	COG3768	UPF0283 membrane protein
CEA93_RS07700	COG3106	COG3106 Predicted ATPase
CEA93_RS07715	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CEA93_RS07720	COG0494	nUDIX hydrolase
CEA93_RS07725	COG0814	amino acid
CEA93_RS07730	COG1760	l-serine dehydratase
CEA93_RS07740	COG2356	endonuclease I
CEA93_RS07745	COG0720	synthase
CEA93_RS07750	COG0840	transmembrane signaling receptor activity
CEA93_RS07755	COG0017	Asparaginyl-tRNA synthetase
CEA93_RS07765	COG2201	protein-glutamate methylesterase activity
CEA93_RS07770	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CEA93_RS07775	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CEA93_RS07780	COG0835	chemotaxis
CEA93_RS07790	COG2198	Histidine kinase
CEA93_RS07790	COG0643	Histidine kinase
CEA93_RS07800	COG0745	RESPONSE REGULATOR receiver
CEA93_RS07805	COG0840	transmembrane signaling receptor activity
CEA93_RS07810	COG3437	response regulator, receiver
CEA93_RS07810	COG2770	Histidine kinase
CEA93_RS07815	COG1448	Aminotransferase
CEA93_RS07820	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
CEA93_RS07835	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CEA93_RS07840	COG1846	Transcriptional regulator
CEA93_RS07855	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CEA93_RS07860	COG3108	Peptidase M15
CEA93_RS07865	COG2989	Protein conserved in bacteria
CEA93_RS07895	COG1940	carbohydrate kinase activity
CEA93_RS07900	COG4771	TonB-dependent receptor
CEA93_RS07900	COG1629	transport
CEA93_RS07905	COG0748	coenzyme F420 binding
CEA93_RS07910	COG3721	Heme iron utilization protein
CEA93_RS07915	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
CEA93_RS07920	COG0811	peptide transport
CEA93_RS07925	COG0848	biopolymer transport protein
CEA93_RS07935	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CEA93_RS07940	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CEA93_RS07945	COG1054	Belongs to the UPF0176 family
CEA93_RS07955	COG0840	transmembrane signaling receptor activity
CEA93_RS07960	COG1621	beta-fructofuranosidase activity
CEA93_RS07970	COG1263	PTS System
CEA93_RS07970	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CEA93_RS07975	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CEA93_RS07980	COG2200	EAL domain
CEA93_RS07985	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CEA93_RS07990	COG0840	transmembrane signaling receptor activity
CEA93_RS08015	COG3220	belongs to the UPF0276 family
CEA93_RS08035	COG1294	oxidase, subunit
CEA93_RS08045	COG0251	oxidation-reduction process
CEA93_RS08065	COG2433	Pfam Transposase IS66
CEA93_RS08110	COG4991	sh3 domain protein
CEA93_RS08110	COG0515	serine threonine protein kinase
CEA93_RS08110	COG3064	Membrane
CEA93_RS08135	COG1716	ATPase activity
CEA93_RS08155	COG1181	Belongs to the D-alanine--D-alanine ligase family
CEA93_RS08230	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CEA93_RS08270	COG0835	chemotaxis
CEA93_RS08270	COG0784	Response regulator, receiver
CEA93_RS08280	COG4565	transcriptional regulatory protein
CEA93_RS08285	COG3290	protein histidine kinase activity
CEA93_RS08300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CEA93_RS08325	COG3063	Type IV pilus biogenesis stability protein PilW
CEA93_RS08340	COG1451	nucleotide metabolic process
CEA93_RS08350	COG0583	DNA-binding transcription factor activity
CEA93_RS08370	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
CEA93_RS08375	COG4139	cobalamin transport
CEA93_RS08380	COG2988	succinylglutamate desuccinylase activity
CEA93_RS08395	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CEA93_RS08400	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CEA93_RS08405	COG3064	Membrane
CEA93_RS08405	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
CEA93_RS08405	COG1073	alpha beta
CEA93_RS08410	COG2994	toxin metabolic process
CEA93_RS08440	COG0702	epimerase
CEA93_RS08445	COG1823	symporter activity
CEA93_RS08450	COG2925	Exonuclease
CEA93_RS08455	COG1380	Effector of murein hydrolase LrgA
CEA93_RS08460	COG1346	cytolysis
CEA93_RS08470	COG5001	Diguanylate cyclase
CEA93_RS08485	COG0500	methyltransferase
CEA93_RS08495	COG0776	regulation of translation
CEA93_RS08500	COG0072	phenylalanine-tRNA ligase activity
CEA93_RS08500	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CEA93_RS08505	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CEA93_RS08545	COG0322	excinuclease ABC activity
CEA93_RS08550	COG2197	response regulator
CEA93_RS08555	COG0417	DNA replication proofreading
CEA93_RS08565	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CEA93_RS08570	COG3099	Belongs to the UPF0263 family
CEA93_RS08575	COG3097	Belongs to the UPF0267 family
CEA93_RS08585	COG1228	amidohydrolase
CEA93_RS08590	COG0010	Belongs to the arginase family
CEA93_RS08600	COG2986	histidine ammonia-lyase
CEA93_RS08615	COG0277	FAD linked oxidase domain protein
CEA93_RS08615	COG0247	lactate metabolic process
CEA93_RS08645	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CEA93_RS08650	COG1960	acyl-CoA dehydrogenase activity
CEA93_RS08675	COG3300	MHYT domain
CEA93_RS08675	COG5001	Diguanylate cyclase
CEA93_RS08800	COG0740	serine-type endopeptidase activity
CEA93_RS08815	COG1802	Transcriptional regulator
CEA93_RS08815	COG4626	Terminase
CEA93_RS08850	COG3772	lysozyme
CEA93_RS08880	COG1403	HNH endonuclease
CEA93_RS08975	COG3081	Nucleoid-associated protein
CEA93_RS09005	COG2404	hydrolase activity, acting on ester bonds
CEA93_RS09100	COG0582	viral genome integration into host DNA
CEA93_RS09115	COG0784	Response regulator, receiver
CEA93_RS09115	COG5002	protein histidine kinase activity
CEA93_RS09135	COG2433	Pfam Transposase IS66
CEA93_RS09140	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CEA93_RS09145	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
CEA93_RS09150	COG2885	chlorophyll binding
CEA93_RS09155	COG0823	Involved in the tonB-independent uptake of proteins
CEA93_RS09170	COG0811	peptide transport
CEA93_RS09175	COG0824	Thioesterase
CEA93_RS09180	COG3790	cyd operon protein YbgE
CEA93_RS09185	COG4890	Cyd operon protein YbgT
CEA93_RS09190	COG1294	oxidase, subunit
CEA93_RS09195	COG1271	oxidase subunit
CEA93_RS09200	COG2255	four-way junction helicase activity
CEA93_RS09205	COG0632	four-way junction helicase activity
CEA93_RS09210	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CEA93_RS09215	COG0215	cysteine-tRNA ligase activity
CEA93_RS09220	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CEA93_RS09225	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CEA93_RS09230	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
CEA93_RS09235	COG3012	SEC-C Motif Domain Protein
CEA93_RS09255	COG3923	Primosomal replication protein n
CEA93_RS09265	COG0840	transmembrane signaling receptor activity
CEA93_RS09270	COG0708	Exodeoxyribonuclease III
CEA93_RS09275	COG4160	amino acid transport
CEA93_RS09305	COG1882	Formate acetyltransferase
CEA93_RS09320	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CEA93_RS09330	COG3013	Belongs to the UPF0304 family
CEA93_RS09335	COG2766	serine protein kinase
CEA93_RS09340	COG2718	Belongs to the UPF0229 family
CEA93_RS09345	COG2719	SpoVR family
CEA93_RS09355	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CEA93_RS09370	COG1132	(ABC) transporter
CEA93_RS09375	COG0658	competence protein
CEA93_RS09375	COG2333	competence protein COMEC
CEA93_RS09385	COG4591	ABC-type transport system involved in lipoprotein release permease component
CEA93_RS09390	COG1136	(ABC) transporter
CEA93_RS09395	COG4591	ABC-type transport system involved in lipoprotein release permease component
CEA93_RS09405	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CEA93_RS09420	COG1252	NADH dehydrogenase
CEA93_RS09425	COG3150	esterase
CEA93_RS09450	COG0537	adenosine 5'-monophosphoramidase activity
CEA93_RS09465	COG2186	Transcriptional regulator
CEA93_RS09470	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CEA93_RS09480	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CEA93_RS09485	COG2226	methyltransferase
CEA93_RS09490	COG0156	8-amino-7-oxononanoate synthase activity
CEA93_RS09495	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CEA93_RS09500	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CEA93_RS09510	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CEA93_RS09515	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CEA93_RS09520	COG0653	protein targeting
CEA93_RS09525	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CEA93_RS09535	COG4120	Belongs to the binding-protein-dependent transport system permease family
CEA93_RS09545	COG3092	negative regulation of chromosome organization
CEA93_RS09550	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CEA93_RS09555	COG0280	phosphate acetyltransferase
CEA93_RS09555	COG0857	belongs to the CobB CobQ family
CEA93_RS09560	COG0435	Glutathione S-transferase
CEA93_RS09570	COG0444	Belongs to the ABC transporter superfamily
CEA93_RS09575	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CEA93_RS09580	COG0601	transmembrane transport
CEA93_RS09620	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CEA93_RS09625	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CEA93_RS09645	COG1216	Glycosyl transferase, family 2
CEA93_RS09675	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CEA93_RS09680	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CEA93_RS09685	COG1028	Short-chain dehydrogenase reductase Sdr
CEA93_RS09710	COG0800	Aldolase
CEA93_RS09715	COG2610	gluconate transmembrane transporter activity
CEA93_RS09720	COG3265	gluconokinase activity
CEA93_RS09725	COG0129	dihydroxy-acid dehydratase activity
CEA93_RS09730	COG1609	Transcriptional regulator
CEA93_RS09745	COG3850	Histidine kinase
CEA93_RS09745	COG5002	protein histidine kinase activity
CEA93_RS09770	COG2194	sulfuric ester hydrolase activity
CEA93_RS09775	COG0642	Histidine kinase
CEA93_RS09780	COG0745	RESPONSE REGULATOR receiver
CEA93_RS09790	COG4221	oxidoreductase activity
CEA93_RS09800	COG1022	Amp-dependent synthetase and ligase
CEA93_RS09825	COG3706	GGDEF domain
CEA93_RS09840	COG3126	Type III secretion system lipoprotein chaperone (YscW)
CEA93_RS09845	COG1946	Acyl-CoA thioesterase
CEA93_RS09850	COG1522	sequence-specific DNA binding
CEA93_RS09900	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CEA93_RS09910	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CEA93_RS09915	COG1169	isochorismate synthase
CEA93_RS09925	COG0436	Aminotransferase
CEA93_RS09930	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
CEA93_RS09935	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CEA93_RS09950	COG0616	signal peptide processing
CEA93_RS09955	COG1028	Short-chain dehydrogenase reductase Sdr
CEA93_RS09960	COG0784	Response regulator, receiver
CEA93_RS09960	COG0835	chemotaxis
CEA93_RS09965	COG1940	carbohydrate kinase activity
CEA93_RS09975	COG4667	esterase of the alpha-beta hydrolase superfamily
CEA93_RS09985	COG0733	neurotransmitter:sodium symporter activity
CEA93_RS09995	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CEA93_RS09995	COG1263	PTS System
CEA93_RS10000	COG0084	hydrolase, TatD family'
CEA93_RS10005	COG0470	DNA polymerase III
CEA93_RS10010	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CEA93_RS10015	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CEA93_RS10020	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CEA93_RS10045	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CEA93_RS10060	COG1399	metal-binding, possibly nucleic acid-binding protein
CEA93_RS10065	COG0424	maF-like protein
CEA93_RS10070	COG0564	pseudouridine synthase activity
CEA93_RS10075	COG1530	ribonuclease E activity
CEA93_RS10085	COG1454	alcohol dehydrogenase
CEA93_RS10085	COG1012	belongs to the aldehyde dehydrogenase family
CEA93_RS10090	COG2095	MarC family integral membrane protein
CEA93_RS10095	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CEA93_RS10100	COG1757	Na H antiporter
CEA93_RS10115	COG3082	Protein of unknown function (DUF1414)
CEA93_RS10120	COG3083	sulfuric ester hydrolase activity
CEA93_RS10130	COG0243	molybdopterin cofactor binding
CEA93_RS10135	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CEA93_RS10150	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CEA93_RS10155	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CEA93_RS10175	COG2853	Lipoprotein
CEA93_RS10190	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CEA93_RS10195	COG1138	Cytochrome C-type biogenesis protein
CEA93_RS10200	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CEA93_RS10210	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CEA93_RS10215	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CEA93_RS10220	COG4133	protoheme IX ABC transporter activity
CEA93_RS10230	COG0835	chemotaxis
CEA93_RS10240	COG1192	Involved in chromosome partitioning
CEA93_RS10245	COG2201	protein-glutamate methylesterase activity
CEA93_RS10250	COG0643	Histidine kinase
CEA93_RS10250	COG2198	Histidine kinase
CEA93_RS10250	COG0784	Response regulator, receiver
CEA93_RS10255	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
CEA93_RS10280	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CEA93_RS10285	COG2062	phosphohistidine phosphatase, SixA
CEA93_RS10290	COG1025	Belongs to the peptidase M16 family
CEA93_RS10295	COG3102	Protein conserved in bacteria
CEA93_RS10320	COG1918	ferrous iron import across plasma membrane
CEA93_RS10325	COG4977	sequence-specific DNA binding
CEA93_RS10330	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
CEA93_RS10335	COG1121	(ABC) transporter
CEA93_RS10340	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CEA93_RS10355	COG0508	dehydrogenase complex catalyzes the overall conversion of
CEA93_RS10360	COG0567	Dehydrogenase, E1 component
CEA93_RS10375	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CEA93_RS10390	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CEA93_RS10400	COG0033	Phosphoglucomutase
CEA93_RS10405	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
CEA93_RS10410	COG0596	Alpha beta hydrolase
CEA93_RS10425	COG1346	cytolysis
CEA93_RS10435	COG0583	DNA-binding transcription factor activity
CEA93_RS10445	COG0735	belongs to the Fur family
CEA93_RS10450	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CEA93_RS10455	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CEA93_RS10460	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CEA93_RS10465	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CEA93_RS10465	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CEA93_RS10470	COG0431	NADPH-dependent FMN reductase
CEA93_RS10480	COG3101	peptidyl-lysine hydroxylation
CEA93_RS10485	COG2860	membrane
CEA93_RS10490	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CEA93_RS10495	COG2890	protein-(glutamine-N5) methyltransferase activity
CEA93_RS10500	COG2840	Smr protein MutS2
CEA93_RS10510	COG1684	flagellar biosynthetic protein fliR
CEA93_RS10515	COG1987	bacterial-type flagellum assembly
CEA93_RS10565	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CEA93_RS10575	COG1677	Flagellar hook-basal body complex protein FliE
CEA93_RS10595	COG1516	flagellar protein fliS
CEA93_RS10605	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CEA93_RS10630	COG2837	iron assimilation
CEA93_RS10655	COG1393	Belongs to the ArsC family
CEA93_RS10675	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
CEA93_RS10690	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CEA93_RS10710	COG4783	chaperone-mediated protein folding
CEA93_RS10715	COG1393	Belongs to the ArsC family
CEA93_RS10735	COG2233	PERMEase
CEA93_RS10740	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CEA93_RS10750	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CEA93_RS10755	COG2912	Transglutaminase-like superfamily
CEA93_RS10760	COG3094	Invasion gene expression up-regulator, SirB
CEA93_RS10765	COG2890	protein-(glutamine-N5) methyltransferase activity
CEA93_RS10770	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CEA93_RS10775	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CEA93_RS10780	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
CEA93_RS10790	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CEA93_RS10795	COG0193	aminoacyl-tRNA hydrolase activity
CEA93_RS10890	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CEA93_RS10900	COG1705	Flagellar rod assembly protein muramidase FlgJ
CEA93_RS10900	COG3951	Flagellar rod assembly protein muramidase FlgJ
CEA93_RS10905	COG1706	bacterial-type flagellum-dependent cell motility
CEA93_RS10910	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CEA93_RS10920	COG4787	bacterial-type flagellum-dependent cell motility
CEA93_RS10925	COG1749	Flagellar hook protein flgE
CEA93_RS10940	COG1815	bacterial-type flagellum-dependent cell motility
CEA93_RS10950	COG0835	chemotaxis
CEA93_RS10950	COG0784	Response regulator, receiver
CEA93_RS10960	COG2747	anti-sigma28 factor FlgM
CEA93_RS11005	COG2608	mercury ion transmembrane transporter activity
CEA93_RS11005	COG2217	Heavy metal translocating P-type atpase
CEA93_RS11030	COG1187	pseudouridine synthase activity
CEA93_RS11035	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CEA93_RS11040	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CEA93_RS11045	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CEA93_RS11050	COG0121	glutamine amidotransferase
CEA93_RS11055	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CEA93_RS11075	COG0328	RNA-DNA hybrid ribonuclease activity
CEA93_RS11080	COG2226	methyltransferase
CEA93_RS11085	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CEA93_RS11090	COG1388	LysM domain
CEA93_RS11090	COG0741	lytic transglycosylase activity
CEA93_RS11105	COG0347	Belongs to the P(II) protein family
CEA93_RS11115	COG0037	tRNA processing
CEA93_RS11120	COG0825	malonyl-CoA metabolic process
CEA93_RS11125	COG0587	DNA-directed DNA polymerase activity
CEA93_RS11135	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CEA93_RS11145	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CEA93_RS11150	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CEA93_RS11155	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
CEA93_RS11165	COG0750	zinc metalloprotease
CEA93_RS11170	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CEA93_RS11175	COG0575	Belongs to the CDS family
CEA93_RS11180	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CEA93_RS11185	COG0233	cytoplasmic translational termination
CEA93_RS11195	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CEA93_RS11200	COG0052	Belongs to the universal ribosomal protein uS2 family
CEA93_RS11205	COG0024	Methionine aminopeptidase
CEA93_RS11210	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CEA93_RS11220	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CEA93_RS11225	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CEA93_RS11230	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CEA93_RS11250	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CEA93_RS11250	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CEA93_RS11255	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CEA93_RS11260	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CEA93_RS11265	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CEA93_RS11275	COG1073	alpha beta
CEA93_RS11280	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CEA93_RS11285	COG2252	PERMEase
CEA93_RS11290	COG2195	Cleaves the N-terminal amino acid of tripeptides
CEA93_RS11295	COG0189	ligase activity
CEA93_RS11295	COG4067	protein conserved in archaea
CEA93_RS11300	COG0189	ligase activity
CEA93_RS11310	COG0733	neurotransmitter:sodium symporter activity
CEA93_RS11325	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CEA93_RS11335	COG1477	protein flavinylation
CEA93_RS11370	COG0271	Belongs to the BolA IbaG family
CEA93_RS11390	COG2211	Major facilitator Superfamily
CEA93_RS11400	COG1595	DNA-templated transcription, initiation
CEA93_RS11415	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CEA93_RS11425	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CEA93_RS11430	COG2166	iron-sulfur cluster assembly
CEA93_RS11435	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CEA93_RS11440	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
CEA93_RS11450	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CEA93_RS11450	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CEA93_RS11460	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CEA93_RS11465	COG1074	ATP-dependent DNA helicase activity
CEA93_RS11470	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CEA93_RS11485	COG3141	response to X-ray
CEA93_RS11490	COG2171	N-acyltransferase activity
CEA93_RS11530	COG1609	Transcriptional regulator
CEA93_RS11540	COG1085	galactose-1-phosphate uridylyltransferase
CEA93_RS11545	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CEA93_RS11560	COG3437	response regulator, receiver
CEA93_RS11560	COG0784	Response regulator, receiver
CEA93_RS11565	COG1022	Amp-dependent synthetase and ligase
CEA93_RS11570	COG4628	conserved protein (DUF2132)
CEA93_RS11575	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CEA93_RS11580	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CEA93_RS11590	COG0560	Phosphoserine phosphatase
CEA93_RS11600	COG0813	purine-nucleoside phosphorylase activity
CEA93_RS11605	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CEA93_RS11610	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CEA93_RS11615	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CEA93_RS11620	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CEA93_RS11625	COG0084	hydrolase, TatD family'
CEA93_RS11630	COG3022	response to hydroperoxide
CEA93_RS11635	COG1115	amino acid carrier protein
CEA93_RS11650	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CEA93_RS11655	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CEA93_RS11660	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
CEA93_RS11665	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CEA93_RS11670	COG0083	homoserine kinase activity
CEA93_RS11685	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CEA93_RS11690	COG0745	RESPONSE REGULATOR receiver
CEA93_RS11700	COG0784	Response regulator, receiver
CEA93_RS11700	COG2198	Histidine kinase
CEA93_RS11700	COG5002	protein histidine kinase activity
CEA93_RS11705	COG1242	4 iron, 4 sulfur cluster binding
CEA93_RS11710	COG0070	glutamate synthase
CEA93_RS11710	COG0067	glutamate synthase
CEA93_RS11710	COG0069	glutamate synthase activity
CEA93_RS11720	COG0067	glutamate synthase
CEA93_RS11720	COG0069	glutamate synthase activity
CEA93_RS11720	COG0070	glutamate synthase
CEA93_RS11725	COG0493	'glutamate synthase
CEA93_RS11740	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CEA93_RS11750	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CEA93_RS11755	COG2860	membrane
CEA93_RS11760	COG0583	DNA-binding transcription factor activity
CEA93_RS11765	COG0730	response to heat
CEA93_RS11770	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CEA93_RS11775	COG0505	Belongs to the CarA family
CEA93_RS11780	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CEA93_RS11785	COG0494	nUDIX hydrolase
CEA93_RS11790	COG0653	protein targeting
CEA93_RS11800	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CEA93_RS11805	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CEA93_RS11810	COG0849	cell division
CEA93_RS11815	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CEA93_RS11820	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CEA93_RS11825	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CEA93_RS11830	COG0772	Belongs to the SEDS family
CEA93_RS11835	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CEA93_RS11845	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CEA93_RS11850	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CEA93_RS11855	COG0768	penicillin binding
CEA93_RS11860	COG3116	cell division
CEA93_RS11865	COG0275	rRNA processing
CEA93_RS11875	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CEA93_RS11880	COG3107	peptidoglycan biosynthetic process
CEA93_RS11885	COG0792	nuclease activity
CEA93_RS11890	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CEA93_RS11900	COG2969	positive regulation of protein catabolic process
CEA93_RS11905	COG0625	glutathione transferase activity
CEA93_RS11910	COG2857	Cytochrome c1
CEA93_RS11915	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CEA93_RS11920	COG0723	plastoquinol--plastocyanin reductase activity
CEA93_RS11930	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CEA93_RS11940	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CEA93_RS11945	COG3105	Protein conserved in bacteria
CEA93_RS11950	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CEA93_RS11955	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CEA93_RS11960	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CEA93_RS11965	COG0187	DNA topoisomerase II activity
CEA93_RS11970	COG3150	esterase
CEA93_RS11980	COG3151	Protein conserved in bacteria
CEA93_RS11985	COG0494	nUDIX hydrolase
CEA93_RS11990	COG1538	Outer membrane efflux protein
CEA93_RS12000	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CEA93_RS12015	COG3025	triphosphatase activity
CEA93_RS12020	COG1392	Phosphate transport regulator
CEA93_RS12025	COG0306	phosphate transporter
CEA93_RS12030	COG4991	sh3 domain protein
CEA93_RS12040	COG3409	Peptidoglycan-binding domain 1 protein
CEA93_RS12040	COG3267	Type II secretory pathway component ExeA
CEA93_RS12045	COG0617	tRNA 3'-terminal CCA addition
CEA93_RS12055	COG0504	CTP synthase activity
CEA93_RS12060	COG3956	TIGRFAM MazG family protein
CEA93_RS12065	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CEA93_RS12070	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CEA93_RS12075	COG3850	Histidine kinase
CEA93_RS12075	COG4999	Histidine kinase
CEA93_RS12075	COG3437	response regulator, receiver
CEA93_RS12075	COG2205	protein histidine kinase activity
CEA93_RS12080	COG0736	holo-[acyl-carrier-protein] synthase activity
CEA93_RS12085	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CEA93_RS12090	COG1381	Involved in DNA repair and RecF pathway recombination
CEA93_RS12095	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CEA93_RS12100	COG0571	ribonuclease III activity
CEA93_RS12110	COG0481	GTPase activity
CEA93_RS12115	COG3086	response to oxidative stress
CEA93_RS12130	COG1595	DNA-templated transcription, initiation
CEA93_RS12135	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CEA93_RS12145	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
CEA93_RS12165	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CEA93_RS12170	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CEA93_RS12175	COG3079	Belongs to the UPF0149 family
CEA93_RS12180	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CEA93_RS12190	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CEA93_RS12200	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CEA93_RS12210	COG0028	Belongs to the TPP enzyme family
CEA93_RS12215	COG1022	Amp-dependent synthetase and ligase
CEA93_RS12220	COG0583	DNA-binding transcription factor activity
CEA93_RS12240	COG0473	3-isopropylmalate dehydrogenase activity
CEA93_RS12250	COG0066	3-isopropylmalate dehydratase activity
CEA93_RS12310	COG0795	lipopolysaccharide-transporting ATPase activity
CEA93_RS12315	COG0795	lipopolysaccharide-transporting ATPase activity
CEA93_RS12320	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CEA93_RS12325	COG2927	DNA polymerase III (CHI subunit)
CEA93_RS12330	COG0525	valine-tRNA ligase activity
CEA93_RS12335	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CEA93_RS12340	COG0564	pseudouridine synthase activity
CEA93_RS12350	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CEA93_RS12360	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CEA93_RS12375	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
CEA93_RS12380	COG0251	oxidation-reduction process
CEA93_RS12395	COG0204	Acyl-transferase
CEA93_RS12400	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CEA93_RS12405	COG5007	Belongs to the BolA IbaG family
CEA93_RS12415	COG2854	intermembrane phospholipid transfer
CEA93_RS12420	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CEA93_RS12425	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CEA93_RS12430	COG1127	ABC transporter
CEA93_RS12440	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CEA93_RS12440	COG0517	IMP dehydrogenase activity
CEA93_RS12445	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CEA93_RS12455	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
CEA93_RS12460	COG1137	ATPase activity
CEA93_RS12470	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CEA93_RS12475	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CEA93_RS12480	COG1660	Displays ATPase and GTPase activities
CEA93_RS12485	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CEA93_RS12490	COG2239	Acts as a magnesium transporter
CEA93_RS12495	COG0312	modulator of DNA gyrase
CEA93_RS12500	COG3028	Belongs to the UPF0307 family
CEA93_RS12505	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
CEA93_RS12510	COG1178	ABC-type Fe3 transport system permease component
CEA93_RS12520	COG0163	prenyltransferase activity
CEA93_RS12525	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CEA93_RS12530	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CEA93_RS12535	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CEA93_RS12545	COG2105	PFAM AIG2 family protein
CEA93_RS12550	COG2911	Protein conserved in bacteria
CEA93_RS12555	COG0729	surface antigen
CEA93_RS12560	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CEA93_RS12565	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
CEA93_RS12600	COG0529	Catalyzes the synthesis of activated sulfate
CEA93_RS12605	COG2895	sulfate adenylyltransferase (ATP) activity
CEA93_RS12610	COG0175	sulfate reduction
CEA93_RS12615	COG1648	precorrin-2 dehydrogenase activity
CEA93_RS12615	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CEA93_RS12620	COG0737	Belongs to the 5'-nucleotidase family
CEA93_RS12660	COG0513	Belongs to the DEAD box helicase family
CEA93_RS12665	COG2153	protein acetylation
CEA93_RS12670	COG3061	Opacity-associated protein A
CEA93_RS12670	COG3266	domain, Protein
CEA93_RS12675	COG0545	Peptidyl-prolyl cis-trans isomerase
CEA93_RS12680	COG0203	ribosomal protein L17
CEA93_RS12685	COG0202	RNA polymerase activity
CEA93_RS12690	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CEA93_RS12695	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CEA93_RS12700	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CEA93_RS12705	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CEA93_RS12710	COG0201	protein transport
CEA93_RS12715	COG0200	Binds to the 23S rRNA
CEA93_RS12720	COG1841	ribosomal large subunit assembly
CEA93_RS12725	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CEA93_RS12735	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CEA93_RS12740	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CEA93_RS12745	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CEA93_RS12750	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CEA93_RS12755	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CEA93_RS12765	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CEA93_RS12775	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CEA93_RS12790	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CEA93_RS12795	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CEA93_RS12805	COG0088	Forms part of the polypeptide exit tunnel
CEA93_RS12810	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CEA93_RS12815	COG0051	transcription antitermination factor activity, RNA binding
CEA93_RS12820	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CEA93_RS12825	COG0557	exoribonuclease II activity
CEA93_RS12830	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
CEA93_RS12840	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CEA93_RS12850	COG1047	Peptidyl-prolyl cis-trans
CEA93_RS12855	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
CEA93_RS12865	COG2249	NAD(P)H dehydrogenase (quinone) activity
CEA93_RS12870	COG0488	(ABC) transporter
CEA93_RS12880	COG0429	hydrolase of the alpha beta-hydrolase fold
CEA93_RS12890	COG3954	Phosphoribulokinase
CEA93_RS12895	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CEA93_RS12905	COG1012	belongs to the aldehyde dehydrogenase family
CEA93_RS12930	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CEA93_RS12940	COG0583	DNA-binding transcription factor activity
CEA93_RS12955	COG0180	Tryptophanyl-tRNA synthetase
CEA93_RS12960	COG0546	phosphoglycolate phosphatase activity
CEA93_RS12965	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CEA93_RS12970	COG0338	D12 class N6 adenine-specific DNA methyltransferase
CEA93_RS12980	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CEA93_RS12985	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CEA93_RS13015	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CEA93_RS13025	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CEA93_RS13025	COG0678	peroxiredoxin activity
CEA93_RS13030	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CEA93_RS13040	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CEA93_RS13040	COG0165	Argininosuccinate lyase
CEA93_RS13045	COG0137	argininosuccinate synthase activity
CEA93_RS13050	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CEA93_RS13055	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CEA93_RS13060	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CEA93_RS13065	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CEA93_RS13075	COG1045	serine acetyltransferase
CEA93_RS13080	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CEA93_RS13090	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CEA93_RS13095	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
CEA93_RS13100	COG1053	succinate dehydrogenase
CEA93_RS13105	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CEA93_RS13110	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
CEA93_RS13120	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CEA93_RS13125	COG1509	lysine 2,3-aminomutase activity
CEA93_RS13140	COG0459	protein refolding
CEA93_RS13145	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CEA93_RS13175	COG0534	Mate efflux family protein
CEA93_RS13180	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CEA93_RS13185	COG1575	Belongs to the MenA family. Type 1 subfamily
CEA93_RS13190	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CEA93_RS13195	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CEA93_RS13205	COG1609	Transcriptional regulator
CEA93_RS13210	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CEA93_RS13220	COG0281	malic enzyme
CEA93_RS13230	COG0626	cystathionine gamma-synthase activity
CEA93_RS13235	COG0527	aspartate kinase activity
CEA93_RS13235	COG0460	homoserine dehydrogenase
CEA93_RS13240	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CEA93_RS13245	COG3074	FtsZ-dependent cytokinesis
CEA93_RS13250	COG1494	fructose-1,6-bisphosphatase
CEA93_RS13255	COG0205	6-phosphofructokinase activity
CEA93_RS13260	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CEA93_RS13270	COG0745	RESPONSE REGULATOR receiver
CEA93_RS13275	COG2205	protein histidine kinase activity
CEA93_RS13280	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CEA93_RS13285	COG1278	Cold shock
CEA93_RS13290	COG3030	protein affecting phage T7 exclusion by the F plasmid
CEA93_RS13295	COG1027	Aspartate ammonia-lyase
CEA93_RS13300	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CEA93_RS13305	COG1288	antiporter activity
CEA93_RS13315	COG0549	Belongs to the carbamate kinase family
CEA93_RS13320	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CEA93_RS13330	COG0540	Belongs to the ATCase OTCase family
CEA93_RS13335	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
CEA93_RS13340	COG1438	arginine binding
CEA93_RS13345	COG4232	protein-disulfide reductase activity
CEA93_RS13365	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CEA93_RS13370	COG2205	protein histidine kinase activity
CEA93_RS13370	COG2198	Histidine kinase
CEA93_RS13370	COG0784	Response regulator, receiver
CEA93_RS13375	COG2814	Major facilitator Superfamily
CEA93_RS13390	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CEA93_RS13395	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CEA93_RS13400	COG0511	ligase activity, forming carbon-carbon bonds
CEA93_RS13405	COG0439	Biotin carboxylase
CEA93_RS13410	COG2264	protein methyltransferase activity
CEA93_RS13415	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CEA93_RS13420	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
CEA93_RS13430	COG0789	Transcriptional regulator
CEA93_RS13435	COG0138	bifunctional purine biosynthesis protein purh
CEA93_RS13440	COG0151	Belongs to the GarS family
CEA93_RS13450	COG0776	regulation of translation
CEA93_RS13455	COG1253	flavin adenine dinucleotide binding
CEA93_RS13460	COG2852	Protein conserved in bacteria
CEA93_RS13465	COG3068	Protein conserved in bacteria
CEA93_RS13470	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CEA93_RS13475	COG0668	transmembrane transport
CEA93_RS13485	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CEA93_RS13490	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CEA93_RS13505	COG0438	transferase activity, transferring glycosyl groups
CEA93_RS13510	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CEA93_RS13545	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CEA93_RS13550	COG1596	polysaccharide export
CEA93_RS13570	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CEA93_RS13580	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CEA93_RS13605	COG3754	Rhamnan synthesis protein F
CEA93_RS13635	COG0463	Glycosyl transferase, family 2
CEA93_RS13645	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CEA93_RS13700	COG1682	transport, permease protein
CEA93_RS13725	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CEA93_RS13735	COG3307	-O-antigen
CEA93_RS13740	COG0859	PFAM glycosyl transferase family 9
CEA93_RS13755	COG1519	Transferase
CEA93_RS13765	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CEA93_RS13780	COG3642	lipopolysaccharide core region biosynthetic process
CEA93_RS13785	COG0859	PFAM glycosyl transferase family 9
CEA93_RS13790	COG0463	Glycosyl transferase, family 2
CEA93_RS13795	COG0859	PFAM glycosyl transferase family 9
CEA93_RS13800	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CEA93_RS13805	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CEA93_RS13815	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CEA93_RS13820	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CEA93_RS13825	COG2003	Belongs to the UPF0758 family
CEA93_RS13830	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CEA93_RS13835	COG1309	transcriptional regulator
CEA93_RS13840	COG1560	Kdo2-lipid A biosynthetic process
CEA93_RS13845	COG1560	Kdo2-lipid A biosynthetic process
CEA93_RS13850	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CEA93_RS13855	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CEA93_RS13860	COG1561	YicC-like family, N-terminal region
CEA93_RS13950	COG2433	Pfam Transposase IS66
CEA93_RS13970	COG2801	Transposase and inactivated derivatives
CEA93_RS13975	COG2433	Pfam Transposase IS66
CEA93_RS13995	COG3344	reverse transcriptase
CEA93_RS14010	COG0612	Peptidase, M16
CEA93_RS14035	COG1120	ATPase activity
CEA93_RS14040	COG4774	siderophore transport
CEA93_RS14045	COG1132	(ABC) transporter
CEA93_RS14050	COG1263	PTS System
CEA93_RS14050	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CEA93_RS14055	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CEA93_RS14075	COG0514	ATP-dependent DNA helicase (RecQ)
CEA93_RS14080	COG2962	Rard protein
CEA93_RS14095	COG0210	DNA helicase
CEA93_RS14100	COG0339	signal peptide processing
CEA93_RS14105	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CEA93_RS14110	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CEA93_RS14140	COG5290	Psort location Cytoplasmic, score
CEA93_RS14150	COG2433	Pfam Transposase IS66
CEA93_RS14170	COG3081	Nucleoid-associated protein
CEA93_RS14190	COG2433	Pfam Transposase IS66
CEA93_RS14245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CEA93_RS14250	COG0601	transmembrane transport
CEA93_RS14300	COG1309	transcriptional regulator
CEA93_RS14305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CEA93_RS14310	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CEA93_RS14315	COG2960	long-chain fatty acid transporting porin activity
CEA93_RS14320	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CEA93_RS14340	COG3078	GTPase activator activity
CEA93_RS14360	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CEA93_RS14360	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CEA93_RS14370	COG0084	hydrolase, TatD family'
CEA93_RS14375	COG0805	protein transport
CEA93_RS14380	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CEA93_RS14385	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CEA93_RS14390	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CEA93_RS14400	COG2226	methyltransferase
CEA93_RS14405	COG1322	Protein conserved in bacteria
CEA93_RS14425	COG2160	L-arabinose isomerase activity
CEA93_RS14435	COG1069	ribulokinase activity
CEA93_RS14440	COG1879	ABC-type sugar transport system periplasmic component
CEA93_RS14445	COG1129	ABC transporter
CEA93_RS14450	COG1172	Belongs to the binding-protein-dependent transport system permease family
CEA93_RS14460	COG2081	HI0933 family
CEA93_RS14475	COG1528	Iron-storage protein
CEA93_RS14480	COG0589	response to stress
CEA93_RS14495	COG0742	ribosomal rna small subunit methyltransferase
CEA93_RS14500	COG1522	sequence-specific DNA binding
CEA93_RS14525	COG0006	proline dipeptidase activity
CEA93_RS14525	COG0006	proline dipeptidase activity
CEA93_RS14530	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CEA93_RS14535	COG2022	thiamine diphosphate biosynthetic process
CEA93_RS14540	COG2104	thiamine diphosphate biosynthetic process
CEA93_RS14550	COG0352	thiamine-phosphate diphosphorylase activity
CEA93_RS14555	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CEA93_RS14605	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
CEA93_RS14610	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CEA93_RS14615	COG1739	Uncharacterized protein family UPF0029
CEA93_RS14625	COG0183	Belongs to the thiolase family
CEA93_RS14630	COG0583	DNA-binding transcription factor activity
CEA93_RS14635	COG2814	Major facilitator Superfamily
CEA93_RS14645	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CEA93_RS14650	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CEA93_RS14655	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CEA93_RS14660	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CEA93_RS14665	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CEA93_RS14670	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CEA93_RS14685	COG3312	ion transport
CEA93_RS14690	COG1475	DNA binding
CEA93_RS14695	COG1192	Involved in chromosome partitioning
CEA93_RS14705	COG0445	tRNA wobble uridine modification
CEA93_RS14735	COG2084	Dehydrogenase
CEA93_RS14740	COG0814	amino acid
CEA93_RS14770	COG0583	DNA-binding transcription factor activity
CEA93_RS14775	COG2910	NAD(P)H-binding
CEA93_RS14785	COG3304	Inner membrane component domain
CEA93_RS14800	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CEA93_RS14805	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CEA93_RS14825	COG0363	glucosamine-6-phosphate deaminase activity
CEA93_RS14835	COG0739	heme binding
CEA93_RS14840	COG2213	PTS system mannitol-specific
CEA93_RS14840	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CEA93_RS14845	COG0246	Mannitol dehydrogenase
CEA93_RS14850	COG3722	fumarate hydratase activity
CEA93_RS14860	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CEA93_RS14865	COG1301	dicarboxylic acid transport
CEA93_RS14870	COG2259	Doxx family
CEA93_RS14895	COG1846	Transcriptional regulator
CEA93_RS14905	COG4943	cyclic-guanylate-specific phosphodiesterase activity
CEA93_RS14910	COG3046	protein related to deoxyribodipyrimidine photolyase
CEA93_RS14915	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CEA93_RS14920	COG0842	Transport permease protein
CEA93_RS14925	COG1131	(ABC) transporter
CEA93_RS14940	COG3842	ATPase activity
CEA93_RS14950	COG1175	transmembrane transport
CEA93_RS14970	COG0513	Belongs to the DEAD box helicase family
CEA93_RS14975	COG0251	oxidation-reduction process
CEA93_RS14980	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CEA93_RS14990	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CEA93_RS14995	COG1328	CTP reductase activity
CEA93_RS15005	COG2130	NADP-dependent
CEA93_RS15010	COG1309	transcriptional regulator
CEA93_RS15025	COG0745	RESPONSE REGULATOR receiver
CEA93_RS15035	COG0564	pseudouridine synthase activity
CEA93_RS15100	COG3829	transcription factor binding
CEA93_RS15125	COG3501	Rhs element vgr protein
CEA93_RS15180	COG0471	metal ion transport
CEA93_RS15185	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
CEA93_RS15195	COG2188	Transcriptional regulator
CEA93_RS15200	COG1131	(ABC) transporter
CEA93_RS15240	COG0671	phosphoesterase, PA-phosphatase related
CEA93_RS15250	COG1132	(ABC) transporter
CEA93_RS15270	COG3623	hexulose-6-phosphate isomerase
CEA93_RS15275	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
CEA93_RS15280	COG0561	phosphatase activity
CEA93_RS15350	COG0366	Alpha amylase catalytic
CEA93_RS15360	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CEA93_RS15370	COG1999	signal sequence binding
CEA93_RS15385	COG0786	glutamate:sodium symporter activity
CEA93_RS15410	COG1566	PFAM secretion protein HlyD family protein
CEA93_RS15435	COG0813	purine-nucleoside phosphorylase activity
CEA93_RS15440	COG3272	Protein of unknown function (DUF1722)
CEA93_RS15445	COG0789	Transcriptional regulator
CEA93_RS15450	COG0415	Belongs to the DNA photolyase family
CEA93_RS15455	COG1376	ErfK ybiS ycfS ynhG family protein
CEA93_RS15455	COG1388	LysM domain
CEA93_RS15465	COG0513	Belongs to the DEAD box helicase family
CEA93_RS15500	COG0366	Alpha amylase catalytic
CEA93_RS15505	COG4989	oxidoreductase activity
CEA93_RS15515	COG0577	efflux transmembrane transporter activity
CEA93_RS15515	COG1136	(ABC) transporter
CEA93_RS15520	COG4591	ABC-type transport system involved in lipoprotein release permease component
CEA93_RS15535	COG0745	RESPONSE REGULATOR receiver
CEA93_RS15535	COG2972	Histidine kinase
CEA93_RS15540	COG3279	Response regulator of the LytR AlgR family
CEA93_RS15545	COG5001	Diguanylate cyclase
CEA93_RS15545	COG4251	negative regulation of phosphorylation
CEA93_RS15545	COG3706	GGDEF domain
CEA93_RS15545	COG2203	Gaf domain
CEA93_RS15555	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CEA93_RS15565	COG3437	response regulator, receiver
CEA93_RS15570	COG2205	protein histidine kinase activity
CEA93_RS15570	COG3437	response regulator, receiver
CEA93_RS15570	COG3850	Histidine kinase
CEA93_RS15570	COG4999	Histidine kinase
CEA93_RS15580	COG0531	amino acid
CEA93_RS15595	COG1151	hydroxylamine reductase activity
CEA93_RS15605	COG5002	protein histidine kinase activity
CEA93_RS15605	COG2205	protein histidine kinase activity
CEA93_RS15605	COG0784	Response regulator, receiver
CEA93_RS15620	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CEA93_RS15625	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CEA93_RS15640	COG0673	inositol 2-dehydrogenase activity
CEA93_RS15645	COG1765	OsmC-like protein
CEA93_RS15650	COG0110	maltose O-acetyltransferase activity
CEA93_RS15665	COG0583	DNA-binding transcription factor activity
CEA93_RS15675	COG0583	DNA-binding transcription factor activity
CEA93_RS15680	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CEA93_RS15685	COG3186	Phenylalanine-4-hydroxylase
CEA93_RS15690	COG2154	pterin-4-alpha-carbinolamine dehydratase
CEA93_RS15695	COG0840	transmembrane signaling receptor activity
CEA93_RS15700	COG0534	Mate efflux family protein
CEA93_RS15705	COG2207	Transcriptional regulator
CEA93_RS15710	COG0784	Response regulator, receiver
CEA93_RS15710	COG3437	response regulator, receiver
CEA93_RS15715	COG4191	Histidine kinase
CEA93_RS15715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CEA93_RS15725	COG2814	Major facilitator Superfamily
CEA93_RS15735	COG0443	Heat shock 70 kDa protein
CEA93_RS15750	COG3240	lipase activity
CEA93_RS15760	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
CEA93_RS15765	COG5380	lipid catabolic process
CEA93_RS15795	COG4607	ABC-type enterochelin transport system periplasmic component
CEA93_RS15800	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CEA93_RS15805	COG4605	iron ion homeostasis
CEA93_RS15810	COG4604	ABC transporter, ATP-binding protein
CEA93_RS15815	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CEA93_RS15820	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CEA93_RS15855	COG2433	Pfam Transposase IS66
CEA93_RS15860	COG1162	GTPase activity
CEA93_RS15870	COG2226	methyltransferase
CEA93_RS15880	COG0861	Integral membrane protein TerC family
CEA93_RS15890	COG2249	NAD(P)H dehydrogenase (quinone) activity
CEA93_RS15895	COG0656	L-ascorbic acid biosynthetic process
CEA93_RS15920	COG1566	PFAM secretion protein HlyD family protein
CEA93_RS15940	COG0509	glycine decarboxylation via glycine cleavage system
CEA93_RS15945	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CEA93_RS15955	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CEA93_RS15970	COG0612	Peptidase, M16
CEA93_RS15985	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
CEA93_RS15985	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CEA93_RS15985	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CEA93_RS15990	COG1105	Belongs to the carbohydrate kinase PfkB family
CEA93_RS15995	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CEA93_RS15995	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CEA93_RS16000	COG1609	Transcriptional regulator
CEA93_RS16005	COG0420	3'-5' exonuclease activity
CEA93_RS16010	COG0419	ATPase involved in DNA repair
CEA93_RS16015	COG0784	Response regulator, receiver
CEA93_RS16015	COG2205	protein histidine kinase activity
CEA93_RS16020	COG0156	8-amino-7-oxononanoate synthase activity
CEA93_RS16030	COG0038	chloride channel
CEA93_RS16035	COG0523	cobalamin synthesis protein
CEA93_RS16040	COG1136	(ABC) transporter
CEA93_RS16050	COG0577	efflux transmembrane transporter activity
CEA93_RS16050	COG1136	(ABC) transporter
CEA93_RS16065	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CEA93_RS16075	COG3675	Pfam Lipase (class 3)
CEA93_RS16095	COG3730	PTS system glucitol sorbitol-specific
CEA93_RS16110	COG1028	Short-chain dehydrogenase reductase Sdr
CEA93_RS16115	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
CEA93_RS16120	COG1349	DNA-binding transcription factor activity
CEA93_RS16125	COG3730	PTS system glucitol sorbitol-specific
CEA93_RS16140	COG3842	ATPase activity
CEA93_RS16150	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CEA93_RS16160	COG2182	Extracellular solute-binding protein
CEA93_RS16165	COG1175	transmembrane transport
CEA93_RS16170	COG3833	ABC-type maltose transport systems, permease component
CEA93_RS16195	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CEA93_RS16200	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CEA93_RS16210	COG3005	denitrification pathway
CEA93_RS16220	COG0243	molybdopterin cofactor binding
CEA93_RS16230	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CEA93_RS16235	COG3850	Histidine kinase
CEA93_RS16240	COG2197	response regulator
CEA93_RS16245	COG3069	C4-dicarboxylate transmembrane transporter activity
CEA93_RS16270	COG1484	DNA-dependent DNA replication
CEA93_RS16290	COG2433	Pfam Transposase IS66
CEA93_RS16310	COG1742	UPF0060 membrane protein
CEA93_RS16395	COG0582	viral genome integration into host DNA
CEA93_RS16410	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CEA93_RS16420	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
CEA93_RS16425	COG0513	Belongs to the DEAD box helicase family
CEA93_RS16455	COG2433	Pfam Transposase IS66
CEA93_RS16490	COG2433	Pfam Transposase IS66
CEA93_RS16505	COG2433	Pfam Transposase IS66
CEA93_RS16715	COG3040	lipid binding
CEA93_RS16785	COG2433	Pfam Transposase IS66
CEA93_RS16815	COG0724	RNA recognition motif
CEA93_RS17060	COG0023	Translation Initiation Factor
CEA93_RS17075	COG1181	Belongs to the D-alanine--D-alanine ligase family
CEA93_RS17085	COG1042	CoA-binding domain protein
CEA93_RS17085	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CEA93_RS17085	COG0045	succinate-CoA ligase (ADP-forming) activity
CEA93_RS17110	COG2433	Pfam Transposase IS66
CEA93_RS17125	COG3140	Belongs to the UPF0181 family
CEA93_RS17140	COG0745	RESPONSE REGULATOR receiver
CEA93_RS17150	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CEA93_RS17155	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CEA93_RS17170	COG3706	GGDEF domain
CEA93_RS17175	COG1278	Cold shock
CEA93_RS17185	COG0840	transmembrane signaling receptor activity
CEA93_RS17200	COG2501	S4 domain
CEA93_RS17205	COG0625	glutathione transferase activity
CEA93_RS17220	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CEA93_RS17225	COG0488	(ABC) transporter
CEA93_RS17240	COG2050	protein possibly involved in aromatic compounds catabolism
CEA93_RS17250	COG2824	Alkylphosphonate utilization operon protein PhnA
CEA93_RS17275	COG2433	Pfam Transposase IS66
CEA93_RS17290	COG1357	PFAM Pentapeptide repeats (8 copies)
CEA93_RS17300	COG2433	Pfam Transposase IS66
CEA93_RS17390	COG2433	Pfam Transposase IS66
CEA93_RS17555	COG2433	Pfam Transposase IS66
CEA93_RS17570	COG0500	methyltransferase
CEA93_RS17575	COG1187	pseudouridine synthase activity
CEA93_RS17590	COG2433	Pfam Transposase IS66
CEA93_RS17595	COG0861	Integral membrane protein TerC family
CEA93_RS17600	COG0737	Belongs to the 5'-nucleotidase family
CEA93_RS17605	COG3593	DNA synthesis involved in DNA repair
CEA93_RS17615	COG0583	DNA-binding transcription factor activity
CEA93_RS17620	COG2116	formate transmembrane transporter activity
CEA93_RS17630	COG3104	oligopeptide transport
CEA93_RS17640	COG2188	Transcriptional regulator
CEA93_RS17645	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CEA93_RS17650	COG1011	Hydrolase
CEA93_RS17655	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
CEA93_RS17665	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CEA93_RS17670	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CEA93_RS17675	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CEA93_RS17680	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CEA93_RS17680	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CEA93_RS17685	COG0302	gtp cyclohydrolase
CEA93_RS17695	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CEA93_RS17700	COG2897	thiosulfate sulfurtransferase activity
CEA93_RS17720	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CEA93_RS17735	COG0545	Peptidyl-prolyl cis-trans isomerase
CEA93_RS17740	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CEA93_RS17745	COG0840	transmembrane signaling receptor activity
CEA93_RS17750	COG2353	YceI-like domain
CEA93_RS17755	COG3038	cytochrome b561
CEA93_RS17765	COG2203	Gaf domain
CEA93_RS17765	COG3706	GGDEF domain
CEA93_RS17765	COG4251	negative regulation of phosphorylation
CEA93_RS17765	COG5001	Diguanylate cyclase
CEA93_RS17770	COG4172	Belongs to the ABC transporter superfamily
CEA93_RS17775	COG4239	(ABC) transporter, permease
CEA93_RS17780	COG4174	ABC transporter (Permease)
CEA93_RS17785	COG4166	transmembrane transport
CEA93_RS17800	COG0189	ligase activity
CEA93_RS17800	COG4067	protein conserved in archaea
CEA93_RS17810	COG0602	queuosine metabolic process
CEA93_RS17815	COG1328	CTP reductase activity
CEA93_RS17830	COG2433	Pfam Transposase IS66
CEA93_RS17855	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CEA93_RS17865	COG0210	DNA helicase
CEA93_RS17905	COG3550	peptidyl-serine autophosphorylation
CEA93_RS17955	COG0602	queuosine metabolic process
CEA93_RS17960	COG1328	CTP reductase activity
CEA93_RS17965	COG1328	CTP reductase activity
CEA93_RS17970	COG3706	GGDEF domain
CEA93_RS18010	COG0446	pyridine nucleotide-disulphide oxidoreductase
CEA93_RS18015	COG3550	peptidyl-serine autophosphorylation
CEA93_RS18025	COG0697	spore germination
CEA93_RS18035	COG3344	reverse transcriptase
CEA93_RS18040	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CEA93_RS18145	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CEA93_RS18150	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CEA93_RS18225	COG0497	DNA recombination
CEA93_RS18230	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
CEA93_RS18230	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
CEA93_RS18280	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CEA93_RS18295	COG3300	MHYT domain
CEA93_RS18295	COG5001	Diguanylate cyclase
CEA93_RS18300	COG4191	Histidine kinase
CEA93_RS18305	COG3852	Histidine kinase
CEA93_RS18315	COG3437	response regulator, receiver
CEA93_RS18330	COG4251	negative regulation of phosphorylation
CEA93_RS18330	COG3706	GGDEF domain
CEA93_RS18330	COG5001	Diguanylate cyclase
CEA93_RS18330	COG2203	Gaf domain
CEA93_RS18340	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CEA93_RS18345	COG4149	molybdate abc transporter
CEA93_RS18350	COG0725	ABC transporter, periplasmic molybdate-binding protein
CEA93_RS18355	COG1492	cobalamin metabolic process
CEA93_RS18360	COG3111	PFAM Bacterial OB fold (BOF) protein
CEA93_RS18385	COG2207	Transcriptional regulator
CEA93_RS18390	COG1979	alcohol dehydrogenase
CEA93_RS18415	COG2271	Major facilitator Superfamily
CEA93_RS18420	COG0469	pyruvate kinase activity
CEA93_RS18425	COG0784	Response regulator, receiver
CEA93_RS18425	COG2198	Histidine kinase
CEA93_RS18425	COG2205	protein histidine kinase activity
CEA93_RS18430	COG1879	ABC-type sugar transport system periplasmic component
CEA93_RS18435	COG1803	Methylglyoxal synthase
CEA93_RS18440	COG0210	DNA helicase
CEA93_RS18445	COG1289	transmembrane transporter activity
CEA93_RS18475	COG0784	Response regulator, receiver
CEA93_RS18475	COG5002	protein histidine kinase activity
CEA93_RS18490	COG2827	Endonuclease containing a URI domain
CEA93_RS18495	COG3132	Protein of unknown function, DUF480
CEA93_RS18515	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CEA93_RS18520	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CEA93_RS18525	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CEA93_RS18530	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
CEA93_RS18535	COG0247	lactate metabolic process
CEA93_RS18540	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CEA93_RS18550	COG3335	DDE superfamily endonuclease
CEA93_RS18590	COG3344	reverse transcriptase
CEA93_RS18600	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CEA93_RS18605	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CEA93_RS18620	COG3550	peptidyl-serine autophosphorylation
CEA93_RS18660	COG3118	belongs to the thioredoxin family
CEA93_RS18680	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CEA93_RS18700	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CEA93_RS18730	COG4176	ABC-type proline glycine betaine transport system permease component
CEA93_RS18735	COG0517	IMP dehydrogenase activity
CEA93_RS18735	COG4175	Glycine betaine
CEA93_RS18750	COG2425	protein containing a von Willebrand factor type A (vWA) domain
CEA93_RS18765	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
CEA93_RS18775	COG0513	Belongs to the DEAD box helicase family
CEA93_RS18780	COG0814	amino acid
CEA93_RS18790	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CEA93_RS18795	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CEA93_RS18805	COG1984	allophanate hydrolase subunit 2
CEA93_RS18815	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
CEA93_RS18820	COG4181	ATPase activity
CEA93_RS18830	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CEA93_RS18835	COG5001	Diguanylate cyclase
CEA93_RS18835	COG1716	ATPase activity
CEA93_RS18845	COG0484	heat shock protein binding
CEA93_RS18890	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CEA93_RS18895	COG5001	Diguanylate cyclase
CEA93_RS18895	COG3300	MHYT domain
CEA93_RS18915	COG0010	Belongs to the arginase family
CEA93_RS18920	COG1166	arginine decarboxylase activity
CEA93_RS18935	COG4176	ABC-type proline glycine betaine transport system permease component
CEA93_RS18940	COG2113	Glycine betaine
CEA93_RS18960	COG0527	aspartate kinase activity
CEA93_RS18965	COG0662	Cupin 2, conserved barrel domain protein
CEA93_RS18970	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CEA93_RS18975	COG0456	acetyltransferase
CEA93_RS18985	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CEA93_RS18990	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CEA93_RS19025	COG0366	Alpha amylase catalytic
CEA93_RS19045	COG0714	Associated with various cellular activities
CEA93_RS19065	COG2304	oxidoreductase activity
CEA93_RS19080	COG3706	GGDEF domain
CEA93_RS19105	COG3530	Putative quorum-sensing-regulated virulence factor
CEA93_RS19110	COG1368	sulfuric ester hydrolase activity
CEA93_RS19120	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CEA93_RS19125	COG1063	alcohol dehydrogenase
CEA93_RS19130	COG0156	8-amino-7-oxononanoate synthase activity
CEA93_RS19140	COG0346	lactoylglutathione lyase activity
CEA93_RS19155	COG2197	response regulator
CEA93_RS19160	COG3851	Histidine kinase
CEA93_RS19165	COG2271	Major facilitator Superfamily
CEA93_RS19175	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CEA93_RS19180	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CEA93_RS19200	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CEA93_RS19205	COG0640	Transcriptional regulator
CEA93_RS19210	COG0798	PFAM Bile acid sodium symporter
CEA93_RS19220	COG0659	secondary active sulfate transmembrane transporter activity
CEA93_RS19225	COG0589	response to stress
CEA93_RS19240	COG0516	GMP reductase activity
CEA93_RS19245	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CEA93_RS19270	COG1278	Cold shock
CEA93_RS19275	COG4681	YaeQ
CEA93_RS19285	COG3604	Transcriptional regulator
CEA93_RS19295	COG2195	Cleaves the N-terminal amino acid of tripeptides
CEA93_RS19300	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CEA93_RS19305	COG3217	Mosc domain protein beta barrel domain protein
CEA93_RS19305	COG0633	Ferredoxin
CEA93_RS19310	COG0418	dihydroorotase activity
CEA93_RS19315	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CEA93_RS19320	COG2354	Protein conserved in bacteria
CEA93_RS19325	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CEA93_RS19375	COG4790	Type iii secretion
CEA93_RS19405	COG2197	response regulator
CEA93_RS19425	COG2199	diguanylate cyclase activity
CEA93_RS19430	COG1349	DNA-binding transcription factor activity
CEA93_RS19455	COG3833	ABC-type maltose transport systems, permease component
CEA93_RS19460	COG1175	transmembrane transport
CEA93_RS19475	COG3842	ATPase activity
CEA93_RS19485	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CEA93_RS19490	COG0784	Response regulator, receiver
CEA93_RS19490	COG0835	chemotaxis
CEA93_RS19495	COG2315	Protein conserved in bacteria
CEA93_RS19500	COG3706	GGDEF domain
CEA93_RS19535	COG5001	Diguanylate cyclase
CEA93_RS19545	COG1741	Belongs to the pirin family
CEA93_RS19555	COG3123	guanosine phosphorylase activity
CEA93_RS19565	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CEA93_RS19575	COG0765	amino acid transport
CEA93_RS19580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CEA93_RS19585	COG0765	amino acid transport
CEA93_RS19590	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CEA93_RS19610	COG0179	Fumarylacetoacetate (FAA) hydrolase
CEA93_RS19620	COG0697	spore germination
CEA93_RS19640	COG2814	Major facilitator Superfamily
CEA93_RS19645	COG0583	DNA-binding transcription factor activity
CEA93_RS19650	COG5001	Diguanylate cyclase
CEA93_RS19655	COG0739	heme binding
CEA93_RS19665	COG0659	secondary active sulfate transmembrane transporter activity
CEA93_RS19670	COG3314	Sporulation integral membrane protein YlbJ
CEA93_RS19685	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CEA93_RS19690	COG0581	inorganic phosphate transmembrane transporter activity
CEA93_RS19695	COG0573	inorganic phosphate transmembrane transporter activity
CEA93_RS19700	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CEA93_RS19710	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CEA93_RS19715	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CEA93_RS19735	COG3047	cAMP biosynthetic process
CEA93_RS19750	COG2271	Major facilitator Superfamily
CEA93_RS19755	COG0584	glycerophosphoryl diester phosphodiesterase
CEA93_RS19765	COG3527	Alpha-acetolactate decarboxylase
CEA93_RS19790	COG0583	DNA-binding transcription factor activity
CEA93_RS19795	COG1620	l-lactate permease
CEA93_RS19815	COG1881	PFAM PEBP family protein
CEA93_RS19820	COG3122	Protein conserved in bacteria
CEA93_RS19850	COG1609	Transcriptional regulator
CEA93_RS19855	COG1472	Belongs to the glycosyl hydrolase 3 family
CEA93_RS19860	COG3842	ATPase activity
CEA93_RS19865	COG0395	ABC-type sugar transport system, permease component
CEA93_RS19880	COG1609	Transcriptional regulator
CEA93_RS19885	COG4580	involved in the transport of maltose and maltodextrins
CEA93_RS19905	COG2211	Major facilitator Superfamily
CEA93_RS19915	COG1067	ATP-dependent peptidase activity
CEA93_RS19925	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CEA93_RS19930	COG0363	glucosamine-6-phosphate deaminase activity
CEA93_RS19940	COG0583	DNA-binding transcription factor activity
CEA93_RS19965	COG1609	Transcriptional regulator
CEA93_RS19970	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CEA93_RS19975	COG1879	ABC-type sugar transport system periplasmic component
CEA93_RS19980	COG1172	Belongs to the binding-protein-dependent transport system permease family
CEA93_RS19985	COG1129	ABC transporter
CEA93_RS19990	COG1869	D-ribose catabolic process
CEA93_RS20005	COG3409	Peptidoglycan-binding domain 1 protein
CEA93_RS20005	COG3501	Rhs element vgr protein
CEA93_RS20015	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CEA93_RS20020	COG1640	4-alpha-glucanotransferase
CEA93_RS20025	COG0058	SHG alpha-glucan phosphorylase activity
CEA93_RS20030	COG2909	trisaccharide binding
CEA93_RS20065	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CEA93_RS20120	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CEA93_RS20130	COG0259	pyridoxamine-phosphate oxidase activity
CEA93_RS20180	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CEA93_RS20185	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CEA93_RS20190	COG0840	transmembrane signaling receptor activity
CEA93_RS20200	COG0835	chemotaxis
CEA93_RS20205	COG2198	Histidine kinase
CEA93_RS20205	COG0643	Histidine kinase
CEA93_RS20210	COG0745	RESPONSE REGULATOR receiver
CEA93_RS20220	COG1444	tRNA N-acetyltransferase activity
CEA93_RS20225	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine