locus-tag	class	description
PL14_RS00010	COG0592	DNA-directed DNA polymerase activity
PL14_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
PL14_RS00020	COG0187	DNA topoisomerase II activity
PL14_RS00025	COG0071	Belongs to the small heat shock protein (HSP20) family
PL14_RS00030	COG3977	Valine--pyruvate aminotransferase
PL14_RS00040	COG0752	glycyl-tRNA synthetase alpha subunit
PL14_RS00045	COG2119	membrane
PL14_RS00055	COG0425	Belongs to the sulfur carrier protein TusA family
PL14_RS00070	COG0604	alcohol dehydrogenase
PL14_RS00085	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
PL14_RS00090	COG3978	acetolactate synthase activity
PL14_RS00100	COG0606	chelatase, subunit chli
PL14_RS00125	COG0840	transmembrane signaling receptor activity
PL14_RS00130	COG0840	transmembrane signaling receptor activity
PL14_RS00140	COG3335	DDE superfamily endonuclease
PL14_RS00160	COG3344	reverse transcriptase
PL14_RS00165	COG0606	chelatase, subunit chli
PL14_RS00175	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
PL14_RS00180	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
PL14_RS00195	COG3084	Protein conserved in bacteria
PL14_RS00200	COG1272	protein, Hemolysin III
PL14_RS00210	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
PL14_RS00215	COG0569	domain protein
PL14_RS00220	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
PL14_RS00220	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PL14_RS00225	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
PL14_RS00230	COG0242	peptide deformylase activity
PL14_RS00235	COG1652	LysM domain
PL14_RS00240	COG0758	DNA mediated transformation
PL14_RS00245	COG2922	Belongs to the Smg family
PL14_RS00250	COG0551	DNA topoisomerase type I activity
PL14_RS00255	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
PL14_RS00260	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
PL14_RS00265	COG0009	L-threonylcarbamoyladenylate synthase
PL14_RS00270	COG0408	coproporphyrinogen oxidase activity
PL14_RS00275	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
PL14_RS00285	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
PL14_RS00315	COG3071	HemY protein
PL14_RS00320	COG2959	enzyme of heme biosynthesis
PL14_RS00325	COG1587	Uroporphyrinogen-III synthase
PL14_RS00350	COG0019	diaminopimelate decarboxylase activity
PL14_RS00355	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
PL14_RS00365	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
PL14_RS00370	COG1011	Hydrolase
PL14_RS00375	COG3148	PFAM DTW domain containing protein
PL14_RS00385	COG0561	phosphatase activity
PL14_RS00390	COG2267	carboxylic ester hydrolase activity
PL14_RS00395	COG1280	lysine exporter protein (LysE YggA)
PL14_RS00400	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
PL14_RS00405	COG0783	Belongs to the Dps family
PL14_RS00430	COG2095	MarC family integral membrane protein
PL14_RS00475	COG1760	l-serine dehydratase
PL14_RS00485	COG2814	Major facilitator Superfamily
PL14_RS00495	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
PL14_RS00500	COG1609	Transcriptional regulator
PL14_RS00550	COG2095	MarC family integral membrane protein
PL14_RS00560	COG0742	ribosomal rna small subunit methyltransferase
PL14_RS00565	COG0552	protein localization to endoplasmic reticulum
PL14_RS00570	COG2884	Cell division ATP-binding protein ftsE
PL14_RS00575	COG2177	Part of the ABC transporter FtsEX involved in
PL14_RS00580	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
PL14_RS00590	COG0705	Rhomboid family
PL14_RS00595	COG1580	Controls the rotational direction of flagella during chemotaxis
PL14_RS00600	COG3161	chorismate lyase activity
PL14_RS00610	COG2937	Belongs to the GPAT DAPAT family
PL14_RS00615	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
PL14_RS00625	COG0534	Mate efflux family protein
PL14_RS00630	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PL14_RS00645	COG3250	beta-galactosidase activity
PL14_RS00655	COG4206	TonB-dependent receptor
PL14_RS00665	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
PL14_RS00740	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
PL14_RS00745	COG3300	MHYT domain
PL14_RS00745	COG5001	Diguanylate cyclase
PL14_RS00755	COG3852	Histidine kinase
PL14_RS00765	COG0174	glutamine synthetase
PL14_RS00770	COG1217	gtp-binding protein TYPA
PL14_RS00775	COG1295	ribonuclease BN
PL14_RS00780	COG1490	D-aminoacyl-tRNA deacylase activity
PL14_RS00785	COG0456	acetyltransferase
PL14_RS00795	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
PL14_RS00800	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
PL14_RS00805	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
PL14_RS00810	COG3031	protein transport across the cell outer membrane
PL14_RS00820	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
PL14_RS00825	COG1459	type II secretion system
PL14_RS00830	COG2165	general secretion pathway protein
PL14_RS00835	COG2165	general secretion pathway protein
PL14_RS00840	COG2165	general secretion pathway protein
PL14_RS00845	COG4795	General secretion pathway protein
PL14_RS00850	COG3156	type II secretion system protein K
PL14_RS00855	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
PL14_RS00860	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
PL14_RS00870	COG1218	3'(2'),5'-bisphosphate nucleotidase
PL14_RS00875	COG0494	nUDIX hydrolase
PL14_RS00880	COG0316	Belongs to the HesB IscA family
PL14_RS00880	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
PL14_RS00885	COG1040	competence protein
PL14_RS00890	COG0596	Alpha beta hydrolase
PL14_RS00900	COG2183	response to ionizing radiation
PL14_RS00905	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PL14_RS00925	COG0583	DNA-binding transcription factor activity
PL14_RS00955	COG2233	PERMEase
PL14_RS00960	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
PL14_RS00965	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PL14_RS00970	COG1758	RNA polymerase activity
PL14_RS00975	COG0194	GDP metabolic process
PL14_RS00980	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
PL14_RS00985	COG0248	Ppx GppA phosphatase
PL14_RS00995	COG3118	belongs to the thioredoxin family
PL14_RS01010	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
PL14_RS01060	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PL14_RS01070	COG0812	UDP-N-acetylmuramate dehydrogenase activity
PL14_RS01075	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
PL14_RS01075	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
PL14_RS01080	COG1072	(Pantothenic acid kinase))
PL14_RS01105	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
PL14_RS01110	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
PL14_RS01115	COG0250	Participates in transcription elongation, termination and antitermination
PL14_RS01130	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
PL14_RS01135	COG0222	ribosome binding
PL14_RS01140	COG0085	RNA polymerase activity
PL14_RS01145	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
PL14_RS01150	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
PL14_RS01155	COG2816	NAD+ diphosphatase activity
PL14_RS01160	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
PL14_RS01175	COG4942	peptidase
PL14_RS01180	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
PL14_RS01195	COG0490	domain, Protein
PL14_RS01195	COG0471	metal ion transport
PL14_RS01205	COG1162	GTPase activity
PL14_RS01210	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
PL14_RS01260	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
PL14_RS01265	COG0802	atpase or kinase
PL14_RS01270	COG0860	N-Acetylmuramoyl-L-alanine amidase
PL14_RS01275	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
PL14_RS01280	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
PL14_RS01290	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
PL14_RS01295	COG0330	HflC and HflK could
PL14_RS01300	COG0330	HflC and HflK could
PL14_RS01305	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
PL14_RS01320	COG0545	Peptidyl-prolyl cis-trans isomerase
PL14_RS01325	COG2964	Protein conserved in bacteria
PL14_RS01330	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
PL14_RS01335	COG2923	Belongs to the DsrF TusC family
PL14_RS01350	COG0049	tRNA binding
PL14_RS01355	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
PL14_RS01360	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
PL14_RS01365	COG0360	Binds together with S18 to 16S ribosomal RNA
PL14_RS01370	COG2965	DNA replication, synthesis of RNA primer
PL14_RS01380	COG0359	binds to the 23S rRNA
PL14_RS01395	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
PL14_RS01400	COG0166	Belongs to the GPI family
PL14_RS01410	COG0735	belongs to the Fur family
PL14_RS01430	COG0582	viral genome integration into host DNA
PL14_RS01435	COG0582	viral genome integration into host DNA
PL14_RS01440	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PL14_RS01460	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
PL14_RS01470	COG0175	sulfate reduction
PL14_RS01545	COG0646	methionine synthase
PL14_RS01545	COG1410	methionine synthase
PL14_RS01550	COG0527	aspartate kinase activity
PL14_RS01555	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
PL14_RS01565	COG2239	Acts as a magnesium transporter
PL14_RS01575	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
PL14_RS01590	COG0629	single-stranded DNA binding
PL14_RS01595	COG2200	EAL domain
PL14_RS01595	COG2199	diguanylate cyclase activity
PL14_RS01620	COG3267	Type II secretory pathway component ExeA
PL14_RS01620	COG3409	Peptidoglycan-binding domain 1 protein
PL14_RS01630	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
PL14_RS01635	COG1459	type II secretion system
PL14_RS01645	COG2165	general secretion pathway protein
PL14_RS01680	COG1077	Cell shape determining protein MreB Mrl
PL14_RS01685	COG1792	Involved in formation and maintenance of cell shape
PL14_RS01690	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
PL14_RS01695	COG0424	maF-like protein
PL14_RS01705	COG3164	Protein of unknown function
PL14_RS01710	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PL14_RS01715	COG0312	modulator of DNA gyrase
PL14_RS01720	COG2235	arginine
PL14_RS01740	COG0589	response to stress
PL14_RS01750	COG2358	TRAP transporter, solute receptor (TAXI family
PL14_RS01755	COG1438	arginine binding
PL14_RS01765	COG0531	amino acid
PL14_RS01770	COG0142	geranyltranstransferase activity
PL14_RS01775	COG0261	This protein binds to 23S rRNA in the presence of protein L20
PL14_RS01780	COG0211	Belongs to the bacterial ribosomal protein bL27 family
PL14_RS01785	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
PL14_RS01790	COG2966	Psort location CytoplasmicMembrane, score
PL14_RS01795	COG3610	response to peptide
PL14_RS01810	COG2967	ApaG domain
PL14_RS01815	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
PL14_RS01820	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
PL14_RS01825	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PL14_RS01830	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
PL14_RS01835	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
PL14_RS01885	COG0741	lytic transglycosylase activity
PL14_RS01890	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
PL14_RS01905	COG2066	Belongs to the glutaminase family
PL14_RS01910	COG0635	Involved in the biosynthesis of porphyrin-containing compound
PL14_RS01915	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
PL14_RS01925	COG1872	DUF167
PL14_RS01930	COG0762	integral membrane protein
PL14_RS01935	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
PL14_RS01940	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
PL14_RS01955	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
PL14_RS01960	COG1678	Uncharacterized ACR, COG1678
PL14_RS01970	COG1385	rRNA (uridine-N3-)-methyltransferase activity
PL14_RS01975	COG2356	endonuclease I
PL14_RS01980	COG3091	SprT-like family
PL14_RS01985	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
PL14_RS01990	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
PL14_RS01995	COG0583	DNA-binding transcription factor activity
PL14_RS02000	COG4771	TonB-dependent receptor
PL14_RS02005	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
PL14_RS02010	COG0126	phosphoglycerate kinase activity
PL14_RS02015	COG0191	fructose-bisphosphate aldolase activity
PL14_RS02020	COG0668	transmembrane transport
PL14_RS02045	COG3706	GGDEF domain
PL14_RS02055	COG1349	DNA-binding transcription factor activity
PL14_RS02080	COG3501	Rhs element vgr protein
PL14_RS02120	COG0358	DNA primase activity
PL14_RS02125	COG1610	YqeY-like protein
PL14_RS02130	COG0828	Belongs to the bacterial ribosomal protein bS21 family
PL14_RS02135	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
PL14_RS02145	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
PL14_RS02150	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
PL14_RS02155	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
PL14_RS02160	COG1968	undecaprenyl-diphosphatase activity
PL14_RS02165	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
PL14_RS02170	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
PL14_RS02175	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
PL14_RS02180	COG0585	pseudouridine synthase activity
PL14_RS02185	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
PL14_RS02190	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
PL14_RS02195	COG4942	peptidase
PL14_RS02195	COG1388	LysM domain
PL14_RS02200	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
PL14_RS02205	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
PL14_RS02225	COG4208	sulfate ABC transporter
PL14_RS02230	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
PL14_RS02235	COG1546	Belongs to the CinA family
PL14_RS02240	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
PL14_RS02245	COG2137	regulation of response to DNA damage stimulus
PL14_RS02250	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
PL14_RS02255	COG0527	aspartate kinase activity
PL14_RS02260	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
PL14_RS02305	COG3630	sodium ion export across plasma membrane
PL14_RS02310	COG5016	pyruvate
PL14_RS02310	COG0511	ligase activity, forming carbon-carbon bonds
PL14_RS02315	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
PL14_RS02325	COG1238	metal cluster binding
PL14_RS02330	COG0612	Peptidase, M16
PL14_RS02340	COG1854	S-ribosylhomocysteine lyase activity
PL14_RS02345	COG4536	flavin adenine dinucleotide binding
PL14_RS02350	COG4137	Cytochrome C assembly protein
PL14_RS02355	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
PL14_RS02360	COG0228	four-way junction DNA binding
PL14_RS02365	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
PL14_RS02370	COG0336	Belongs to the RNA methyltransferase TrmD family
PL14_RS02375	COG0335	large ribosomal subunit rRNA binding
PL14_RS02385	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
PL14_RS02390	COG0237	dephospho-CoA kinase activity
PL14_RS02400	COG1459	type II secretion system
PL14_RS02405	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
PL14_RS02415	COG0157	Belongs to the NadC ModD family
PL14_RS02425	COG0716	FMN binding
PL14_RS02430	COG4974	Belongs to the 'phage' integrase family
PL14_RS02435	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
PL14_RS02440	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
PL14_RS02445	COG2186	Transcriptional regulator
PL14_RS02450	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
PL14_RS02455	COG0508	dehydrogenase complex catalyzes the overall conversion of
PL14_RS02460	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PL14_RS02475	COG0288	reversible hydration of carbon dioxide
PL14_RS02480	COG0659	secondary active sulfate transmembrane transporter activity
PL14_RS02485	COG1131	(ABC) transporter
PL14_RS02490	COG0842	Transport permease protein
PL14_RS02505	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
PL14_RS02515	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
PL14_RS02525	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PL14_RS02530	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
PL14_RS02535	COG1489	DNA binding
PL14_RS02540	COG1643	Atp-dependent helicase
PL14_RS02545	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PL14_RS02550	COG1752	Esterase of the alpha-beta hydrolase superfamily
PL14_RS02555	COG1049	propionate catabolic process, 2-methylcitrate cycle
PL14_RS02560	COG1929	Belongs to the glycerate kinase type-1 family
PL14_RS02565	COG2610	gluconate transmembrane transporter activity
PL14_RS02570	COG3835	regulator
PL14_RS02575	COG3112	Uncharacterised protein family (UPF0231)
PL14_RS02585	COG0004	ammonium transporteR
PL14_RS02590	COG1840	ABC-type Fe3 transport system, periplasmic component
PL14_RS02600	COG3842	ATPase activity
PL14_RS02605	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PL14_RS02620	COG2971	BadF BadG BcrA BcrD
PL14_RS02630	COG4608	Belongs to the ABC transporter superfamily
PL14_RS02635	COG0444	Belongs to the ABC transporter superfamily
PL14_RS02640	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PL14_RS02655	COG0784	Response regulator, receiver
PL14_RS02655	COG2205	protein histidine kinase activity
PL14_RS02665	COG0628	permease
PL14_RS02670	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
PL14_RS02675	COG0316	Belongs to the HesB IscA family
PL14_RS02690	COG0739	heme binding
PL14_RS02695	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
PL14_RS02705	COG2239	Acts as a magnesium transporter
PL14_RS02710	COG2027	D-alanyl-D-alanine carboxypeptidase
PL14_RS02720	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PL14_RS02725	COG1534	Rna-binding protein
PL14_RS02730	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
PL14_RS02735	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PL14_RS02740	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
PL14_RS02745	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PL14_RS02750	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
PL14_RS02765	COG0779	Required for maturation of 30S ribosomal subunits
PL14_RS02770	COG0195	Participates in both transcription termination and antitermination
PL14_RS02785	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
PL14_RS02790	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
PL14_RS02805	COG1846	Transcriptional regulator
PL14_RS02815	COG0826	peptidase U32
PL14_RS02820	COG0826	peptidase U32
PL14_RS02830	COG3154	lipid carrier protein
PL14_RS02835	COG3153	acetyltransferase
PL14_RS02840	COG3385	transposase activity
PL14_RS02865	COG0513	Belongs to the DEAD box helicase family
PL14_RS02870	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
PL14_RS02880	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
PL14_RS02885	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
PL14_RS02890	COG2204	response regulator
PL14_RS02900	COG0667	Aldo Keto reductase
PL14_RS02910	COG0494	nUDIX hydrolase
PL14_RS02915	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
PL14_RS02920	COG0730	response to heat
PL14_RS02930	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
PL14_RS02935	COG1283	sodium-dependent phosphate transmembrane transporter activity
PL14_RS02940	COG0583	DNA-binding transcription factor activity
PL14_RS02945	COG0640	Transcriptional regulator
PL14_RS02950	COG0268	Binds directly to 16S ribosomal RNA
PL14_RS02955	COG0728	peptidoglycan biosynthetic process
PL14_RS02960	COG0196	riboflavin kinase activity
PL14_RS02970	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
PL14_RS02975	COG1047	Peptidyl-prolyl cis-trans
PL14_RS02980	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
PL14_RS02985	COG1966	Carbon starvation protein
PL14_RS02995	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
PL14_RS03000	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
PL14_RS03010	COG3279	Response regulator of the LytR AlgR family
PL14_RS03015	COG3275	phosphorelay sensor kinase activity
PL14_RS03020	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
PL14_RS03025	COG0287	Prephenate dehydrogenase
PL14_RS03025	COG1605	Chorismate mutase
PL14_RS03035	COG0488	(ABC) transporter
PL14_RS03045	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
PL14_RS03050	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
PL14_RS03055	COG5001	Diguanylate cyclase
PL14_RS03060	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
PL14_RS03065	COG0077	Prephenate dehydratase
PL14_RS03065	COG1605	Chorismate mutase
PL14_RS03070	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
PL14_RS03075	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PL14_RS03080	COG0564	pseudouridine synthase activity
PL14_RS03085	COG1496	oxidoreductase activity
PL14_RS03090	COG0542	response to heat
PL14_RS03135	COG0826	peptidase U32
PL14_RS03145	COG0745	RESPONSE REGULATOR receiver
PL14_RS03150	COG5002	protein histidine kinase activity
PL14_RS03160	COG0248	Ppx GppA phosphatase
PL14_RS03165	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
PL14_RS03175	COG0581	inorganic phosphate transmembrane transporter activity
PL14_RS03180	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
PL14_RS03185	COG0704	Plays a role in the regulation of phosphate uptake
PL14_RS03195	COG0450	alkyl hydroperoxide reductase
PL14_RS03200	COG0583	DNA-binding transcription factor activity
PL14_RS03205	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
PL14_RS03215	COG0517	IMP dehydrogenase activity
PL14_RS03225	COG0343	queuine tRNA-ribosyltransferase activity
PL14_RS03230	COG1862	Preprotein translocase
PL14_RS03235	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PL14_RS03240	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PL14_RS03245	COG0483	inositol monophosphate 1-phosphatase activity
PL14_RS03250	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
PL14_RS03255	COG1959	2 iron, 2 sulfur cluster binding
PL14_RS03265	COG0822	iron-sulfur transferase activity
PL14_RS03270	COG0316	Belongs to the HesB IscA family
PL14_RS03280	COG0443	Heat shock 70 kDa protein
PL14_RS03285	COG0633	Ferredoxin
PL14_RS03290	COG2975	iron-sulfur cluster assembly
PL14_RS03295	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
PL14_RS03300	COG0105	UTP biosynthetic process
PL14_RS03310	COG1426	Protein conserved in bacteria
PL14_RS03315	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
PL14_RS03320	COG0124	histidyl-tRNA synthetase
PL14_RS03325	COG2976	Protein conserved in bacteria
PL14_RS03330	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PL14_RS03335	COG1160	GTP binding
PL14_RS03350	COG0517	IMP dehydrogenase activity
PL14_RS03350	COG0516	GMP reductase activity
PL14_RS03355	COG0519	Catalyzes the synthesis of GMP from XMP
PL14_RS03355	COG0518	GMP synthase (glutamine-hydrolyzing) activity
PL14_RS03360	COG0351	phosphomethylpyrimidine kinase
PL14_RS03370	COG1584	GPR1 FUN34 yaaH family protein
PL14_RS03375	COG1115	amino acid carrier protein
PL14_RS03400	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
PL14_RS03400	COG3711	transcriptional antiterminator
PL14_RS03415	COG3964	amidohydrolase
PL14_RS03445	COG0556	nucleotide-excision repair
PL14_RS03550	COG2003	Belongs to the UPF0758 family
PL14_RS03575	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
PL14_RS03600	COG0514	ATP-dependent DNA helicase (RecQ)
PL14_RS03645	COG0582	viral genome integration into host DNA
PL14_RS03660	COG2867	negative regulation of translational initiation
PL14_RS03665	COG2914	Belongs to the UPF0125 (RnfH) family
PL14_RS03670	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PL14_RS03675	COG0497	DNA recombination
PL14_RS03680	COG0814	amino acid
PL14_RS03685	COG3033	Beta-eliminating lyase
PL14_RS03690	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
PL14_RS03695	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
PL14_RS03700	COG0443	Heat shock 70 kDa protein
PL14_RS03705	COG0484	heat shock protein binding
PL14_RS03735	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
PL14_RS03740	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
PL14_RS03750	COG0583	DNA-binding transcription factor activity
PL14_RS03755	COG0590	tRNA wobble adenosine to inosine editing
PL14_RS03760	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
PL14_RS03765	COG0047	phosphoribosylformylglycinamidine synthase activity
PL14_RS03765	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
PL14_RS03785	COG2979	Protein of unknown function (DUF533)
PL14_RS03790	COG0442	prolyl-tRNA aminoacylation
PL14_RS03795	COG1720	tRNA m6t6A37 methyltransferase activity
PL14_RS03800	COG0254	rRNA binding
PL14_RS03835	COG3098	single-species biofilm formation
PL14_RS03840	COG0564	pseudouridine synthase activity
PL14_RS03845	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
PL14_RS03850	COG0142	geranyltranstransferase activity
PL14_RS03855	COG1722	exodeoxyribonuclease VII activity
PL14_RS03860	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
PL14_RS03870	COG0301	tRNA thio-modification
PL14_RS03870	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PL14_RS03875	COG0583	DNA-binding transcription factor activity
PL14_RS03880	COG2363	Small membrane protein
PL14_RS03885	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
PL14_RS03890	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PL14_RS03895	COG1611	Belongs to the LOG family
PL14_RS03920	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
PL14_RS03925	COG1464	Belongs to the NlpA lipoprotein family
PL14_RS03930	COG2011	ABC-type metal ion transport system permease component
PL14_RS03935	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
PL14_RS03940	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
PL14_RS03955	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PL14_RS03955	COG1263	PTS System
PL14_RS03960	COG0366	Alpha amylase catalytic
PL14_RS03965	COG0745	RESPONSE REGULATOR receiver
PL14_RS03970	COG2205	protein histidine kinase activity
PL14_RS04005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PL14_RS04010	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PL14_RS04015	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PL14_RS04020	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
PL14_RS04025	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
PL14_RS04065	COG5433	transposase activity
PL14_RS04070	COG1045	serine acetyltransferase
PL14_RS04080	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
PL14_RS04105	COG0489	protein tyrosine kinase activity
PL14_RS04110	COG1596	polysaccharide export
PL14_RS04140	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
PL14_RS04145	COG0321	lipoyl(octanoyl) transferase activity
PL14_RS04150	COG2921	Belongs to the UPF0250 family
PL14_RS04155	COG1686	Belongs to the peptidase S11 family
PL14_RS04160	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
PL14_RS04165	COG0772	Belongs to the SEDS family
PL14_RS04170	COG0768	penicillin binding
PL14_RS04175	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
PL14_RS04180	COG0799	negative regulation of ribosome biogenesis
PL14_RS04185	COG1466	dna polymerase III delta subunit
PL14_RS04190	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
PL14_RS04195	COG0495	leucyl-tRNA aminoacylation
PL14_RS04200	COG2888	peptidyl-tyrosine sulfation
PL14_RS04205	COG0815	Transfers the fatty acyl group on membrane lipoproteins
PL14_RS04210	COG4535	Mg2 and Co2 transporter CorC
PL14_RS04215	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
PL14_RS04220	COG1702	phosphate starvation-inducible protein PhoH
PL14_RS04225	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PL14_RS04230	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PL14_RS04235	COG2190	(PTS) system
PL14_RS04240	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
PL14_RS04245	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
PL14_RS04250	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
PL14_RS04255	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
PL14_RS04260	COG3115	cell septum assembly
PL14_RS04265	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
PL14_RS04280	COG0789	Transcriptional regulator
PL14_RS04290	COG0330	HflC and HflK could
PL14_RS04295	COG3118	belongs to the thioredoxin family
PL14_RS04300	COG1090	epimerase
PL14_RS04305	COG0622	Phosphoesterase
PL14_RS04320	COG3710	Transcriptional regulator
PL14_RS04325	COG0326	Molecular chaperone. Has ATPase activity
PL14_RS04335	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
PL14_RS04340	COG3104	oligopeptide transport
PL14_RS04350	COG0367	asparagine synthase
PL14_RS04355	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
PL14_RS04355	COG4651	solute:proton antiporter activity
PL14_RS04360	COG1846	Transcriptional regulator
PL14_RS04360	COG1940	carbohydrate kinase activity
PL14_RS04365	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
PL14_RS04370	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PL14_RS04370	COG2190	(PTS) system
PL14_RS04370	COG1263	PTS System
PL14_RS04375	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PL14_RS04385	COG0101	tRNA pseudouridine synthase activity
PL14_RS04390	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
PL14_RS04395	COG0285	dihydrofolate synthase activity
PL14_RS04400	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
PL14_RS04405	COG1286	toxin biosynthetic process
PL14_RS04410	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
PL14_RS04415	COG2056	Na+-H+ antiporter family
PL14_RS04420	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
PL14_RS04430	COG0346	lactoylglutathione lyase activity
PL14_RS04435	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
PL14_RS04440	COG4660	Part of a membrane complex involved in electron transport
PL14_RS04445	COG4659	FMN binding
PL14_RS04450	COG4658	electron transport chain
PL14_RS04455	COG4656	Part of a membrane complex involved in electron transport
PL14_RS04460	COG2878	Part of a membrane complex involved in electron transport
PL14_RS04465	COG4657	Part of a membrane complex involved in electron transport
PL14_RS04475	COG4774	siderophore transport
PL14_RS04475	COG1629	transport
PL14_RS04480	COG2382	esterase
PL14_RS04500	COG3433	isochorismatase activity
PL14_RS04500	COG1535	isochorismatase
PL14_RS04505	COG1021	2,3-dihydroxybenzoate-AMP ligase
PL14_RS04510	COG1169	isochorismate synthase
PL14_RS04515	COG1028	Short-chain dehydrogenase reductase Sdr
PL14_RS04520	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
PL14_RS04530	COG4771	TonB-dependent receptor
PL14_RS04535	COG0657	acetylesterase activity
PL14_RS04545	COG0583	DNA-binding transcription factor activity
PL14_RS04550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PL14_RS04555	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PL14_RS04560	COG1902	pentaerythritol trinitrate reductase activity
PL14_RS04570	COG2814	Major facilitator Superfamily
PL14_RS04575	COG1028	Short-chain dehydrogenase reductase Sdr
PL14_RS04590	COG0556	nucleotide-excision repair
PL14_RS04595	COG2204	response regulator
PL14_RS04600	COG2198	Histidine kinase
PL14_RS04605	COG0391	Required for morphogenesis under gluconeogenic growth conditions
PL14_RS04610	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
PL14_RS04615	COG0521	Mo-molybdopterin cofactor biosynthetic process
PL14_RS04625	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
PL14_RS04630	COG0314	molybdopterin synthase activity
PL14_RS04635	COG2199	diguanylate cyclase activity
PL14_RS04640	COG0517	IMP dehydrogenase activity
PL14_RS04640	COG0617	tRNA 3'-terminal CCA addition
PL14_RS04640	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
PL14_RS04650	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
PL14_RS04660	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PL14_RS04660	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PL14_RS04665	COG0489	protein tyrosine kinase activity
PL14_RS04670	COG0572	uridine kinase
PL14_RS04675	COG2982	Protein involved in outer membrane biogenesis
PL14_RS04680	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
PL14_RS04685	COG2067	long-chain fatty acid transport protein
PL14_RS04700	COG1595	DNA-templated transcription, initiation
PL14_RS04705	COG0183	Belongs to the thiolase family
PL14_RS04710	COG1250	3-hydroxyacyl-CoA dehydrogenase
PL14_RS04710	COG1024	Enoyl-CoA hydratase
PL14_RS04715	COG0778	Nitroreductase
PL14_RS04720	COG0583	DNA-binding transcription factor activity
PL14_RS04725	COG0745	RESPONSE REGULATOR receiver
PL14_RS04730	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
PL14_RS04745	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
PL14_RS04755	COG2983	Belongs to the UPF0260 family
PL14_RS04770	COG2226	methyltransferase
PL14_RS04785	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PL14_RS04795	COG3139	Protein of unknown function (DUF1315)
PL14_RS04800	COG0252	asparaginase activity
PL14_RS04805	COG0616	signal peptide processing
PL14_RS04810	COG1902	pentaerythritol trinitrate reductase activity
PL14_RS04810	COG0446	pyridine nucleotide-disulphide oxidoreductase
PL14_RS04815	COG0788	formyltetrahydrofolate deformylase activity
PL14_RS04825	COG1199	ATP-dependent helicase activity
PL14_RS04830	COG1214	PFAM Peptidase M22, glycoprotease
PL14_RS04845	COG0596	Alpha beta hydrolase
PL14_RS04850	COG0318	PFAM AMP-dependent synthetase and ligase
PL14_RS04855	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
PL14_RS04860	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
PL14_RS04865	COG2894	cell division
PL14_RS04875	COG3100	YcgL domain-containing protein
PL14_RS04880	COG2951	lytic endotransglycosylase activity
PL14_RS04885	COG0583	DNA-binding transcription factor activity
PL14_RS04890	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
PL14_RS04915	COG4628	conserved protein (DUF2132)
PL14_RS04930	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PL14_RS04940	COG0513	Belongs to the DEAD box helicase family
PL14_RS04950	COG1760	l-serine dehydratase
PL14_RS04965	COG3335	DDE superfamily endonuclease
PL14_RS04980	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
PL14_RS04990	COG2205	protein histidine kinase activity
PL14_RS04995	COG1653	transport
PL14_RS05005	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
PL14_RS05010	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
PL14_RS05015	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
PL14_RS05035	COG0544	peptidyl-prolyl cis-trans isomerase activity
PL14_RS05045	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
PL14_RS05050	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
PL14_RS05055	COG0776	regulation of translation
PL14_RS05060	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PL14_RS05065	COG1555	photosystem II stabilization
PL14_RS05070	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
PL14_RS05075	COG0539	negative regulation of cytoplasmic translation
PL14_RS05080	COG0776	regulation of translation
PL14_RS05085	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
PL14_RS05090	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
PL14_RS05105	COG0583	DNA-binding transcription factor activity
PL14_RS05115	COG0686	Belongs to the AlaDH PNT family
PL14_RS05120	COG1522	sequence-specific DNA binding
PL14_RS05125	COG1674	ftsk spoiiie
PL14_RS05130	COG0501	Belongs to the peptidase M48B family
PL14_RS05140	COG0300	oxidoreductase activity
PL14_RS05155	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
PL14_RS05165	COG2268	Band 7 protein
PL14_RS05175	COG1032	radical SAM domain protein
PL14_RS05200	COG0583	DNA-binding transcription factor activity
PL14_RS05205	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
PL14_RS05215	COG2350	Protein conserved in bacteria
PL14_RS05245	COG0159	tryptophan synthase activity
PL14_RS05250	COG0133	tryptophan synthase activity
PL14_RS05255	COG0134	indole-3-glycerol-phosphate synthase activity
PL14_RS05255	COG0135	phosphoribosylanthranilate isomerase activity
PL14_RS05260	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
PL14_RS05265	COG0512	Glutamine amidotransferase of anthranilate synthase
PL14_RS05270	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
PL14_RS05280	COG0613	PHP domain protein
PL14_RS05285	COG0009	L-threonylcarbamoyladenylate synthase
PL14_RS05290	COG1187	pseudouridine synthase activity
PL14_RS05295	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
PL14_RS05300	COG4988	ABC transporter
PL14_RS05305	COG0492	ferredoxin-NADP+ reductase activity
PL14_RS05325	COG2949	membrane
PL14_RS05335	COG0281	malic enzyme
PL14_RS05345	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
PL14_RS05350	COG2985	domain, Protein
PL14_RS05350	COG3273	potassium ion transport
PL14_RS05355	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
PL14_RS05365	COG1737	Transcriptional regulator
PL14_RS05370	COG0076	glutamate decarboxylase activity
PL14_RS05380	COG2431	L-lysine efflux transmembrane transporter activity
PL14_RS05390	COG3070	regulator of competence-specific genes
PL14_RS05405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PL14_RS05405	COG4191	Histidine kinase
PL14_RS05415	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
PL14_RS05420	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
PL14_RS05425	COG2915	High frequency lysogenization protein hflD homolog
PL14_RS05430	COG0482	sulfurtransferase activity
PL14_RS05440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PL14_RS05445	COG2916	Histone family protein nucleoid-structuring protein H-NS
PL14_RS05450	COG1757	Na H antiporter
PL14_RS05455	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
PL14_RS05460	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
PL14_RS05465	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
PL14_RS05470	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
PL14_RS05470	COG0131	Imidazoleglycerol-phosphate dehydratase
PL14_RS05475	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
PL14_RS05480	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
PL14_RS05485	COG0107	imidazoleglycerol-phosphate synthase activity
PL14_RS05490	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
PL14_RS05490	COG0140	phosphoribosyl-ATP diphosphatase activity
PL14_RS05495	COG1187	pseudouridine synthase activity
PL14_RS05505	COG1278	Cold shock
PL14_RS05510	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
PL14_RS05515	COG0542	response to heat
PL14_RS05520	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
PL14_RS05525	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
PL14_RS05530	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
PL14_RS05545	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
PL14_RS05550	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
PL14_RS05555	COG0297	glycogen (starch) synthase activity
PL14_RS05575	COG3070	regulator of competence-specific genes
PL14_RS05580	COG1609	Transcriptional regulator
PL14_RS05590	COG0745	RESPONSE REGULATOR receiver
PL14_RS05595	COG1434	Gram-negative-bacterium-type cell wall biogenesis
PL14_RS05600	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PL14_RS05610	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
PL14_RS05615	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
PL14_RS05630	COG4067	protein conserved in archaea
PL14_RS05630	COG0189	ligase activity
PL14_RS05635	COG0500	methyltransferase
PL14_RS05645	COG1801	Protein of unknown function DUF72
PL14_RS05650	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
PL14_RS05655	COG1435	thymidine kinase activity
PL14_RS05665	COG1434	Gram-negative-bacterium-type cell wall biogenesis
PL14_RS05690	COG2116	formate transmembrane transporter activity
PL14_RS05695	COG4459	periplasmic nitrate reductase
PL14_RS05700	COG3005	denitrification pathway
PL14_RS05705	COG0243	molybdopterin cofactor binding
PL14_RS05715	COG1227	inorganic diphosphatase activity
PL14_RS05725	COG0210	DNA helicase
PL14_RS05755	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
PL14_RS05760	COG4172	Belongs to the ABC transporter superfamily
PL14_RS05770	COG4171	peptide transport system, permease
PL14_RS05785	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
PL14_RS05790	COG1842	Phage shock protein A
PL14_RS05805	COG0519	Catalyzes the synthesis of GMP from XMP
PL14_RS05810	COG0626	cystathionine gamma-synthase activity
PL14_RS05820	COG0733	neurotransmitter:sodium symporter activity
PL14_RS05825	COG0564	pseudouridine synthase activity
PL14_RS05835	COG2200	EAL domain
PL14_RS05840	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
PL14_RS05845	COG4136	ATPase activity
PL14_RS05850	COG4135	transport system, permease component
PL14_RS05855	COG4134	Bacterial extracellular solute-binding protein
PL14_RS05865	COG3313	Fe-S protein
PL14_RS05875	COG0737	Belongs to the 5'-nucleotidase family
PL14_RS05885	COG0513	Belongs to the DEAD box helicase family
PL14_RS05900	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
PL14_RS05905	COG2205	protein histidine kinase activity
PL14_RS05920	COG1061	Type III restriction enzyme res subunit
PL14_RS05925	COG1187	pseudouridine synthase activity
PL14_RS05930	COG2814	Major facilitator Superfamily
PL14_RS05940	COG0702	epimerase
PL14_RS05945	COG0534	Mate efflux family protein
PL14_RS05950	COG4181	ATPase activity
PL14_RS05965	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
PL14_RS05990	COG0840	transmembrane signaling receptor activity
PL14_RS06020	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PL14_RS06025	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PL14_RS06030	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PL14_RS06040	COG0840	transmembrane signaling receptor activity
PL14_RS06050	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PL14_RS06050	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
PL14_RS06050	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PL14_RS06055	COG2207	Transcriptional regulator
PL14_RS06065	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PL14_RS06075	COG1342	Belongs to the UPF0251 family
PL14_RS06095	COG1129	ABC transporter
PL14_RS06110	COG1902	pentaerythritol trinitrate reductase activity
PL14_RS06115	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
PL14_RS06120	COG5002	protein histidine kinase activity
PL14_RS06125	COG0745	RESPONSE REGULATOR receiver
PL14_RS06155	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
PL14_RS06160	COG0372	Belongs to the citrate synthase family
PL14_RS06165	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
PL14_RS06170	COG2828	Protein conserved in bacteria
PL14_RS06190	COG0561	phosphatase activity
PL14_RS06195	COG0602	queuosine metabolic process
PL14_RS06225	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
PL14_RS06230	COG1254	Belongs to the acylphosphatase family
PL14_RS06235	COG2920	part of a sulfur-relay system
PL14_RS06240	COG0670	Belongs to the BI1 family
PL14_RS06245	COG1126	abc transporter atp-binding protein
PL14_RS06250	COG0765	amino acid transport
PL14_RS06255	COG4597	amino acid ABC transporter
PL14_RS06260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PL14_RS06265	COG1648	precorrin-2 dehydrogenase activity
PL14_RS06265	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
PL14_RS06275	COG1666	GTP binding
PL14_RS06280	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
PL14_RS06285	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
PL14_RS06285	COG0574	Belongs to the PEP-utilizing enzyme family
PL14_RS06300	COG2996	Protein conserved in bacteria
PL14_RS06315	COG3008	intermembrane lipid transfer
PL14_RS06320	COG2995	paraquat-inducible protein a
PL14_RS06325	COG1132	(ABC) transporter
PL14_RS06330	COG1956	GAF domain-containing protein
PL14_RS06335	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
PL14_RS06350	COG0308	aminopeptidase N
PL14_RS06360	COG2902	Dehydrogenase
PL14_RS06365	COG0167	dihydroorotate dehydrogenase activity
PL14_RS06385	COG0488	(ABC) transporter
PL14_RS06400	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PL14_RS06405	COG1067	ATP-dependent peptidase activity
PL14_RS06410	COG3120	sequence-specific DNA binding
PL14_RS06460	COG3278	Belongs to the heme-copper respiratory oxidase family
PL14_RS06475	COG2010	Cytochrome c
PL14_RS06485	COG2217	Heavy metal translocating P-type atpase
PL14_RS06500	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PL14_RS06505	COG0589	response to stress
PL14_RS06530	COG3842	ATPase activity
PL14_RS06535	COG1176	ABC-type spermidine putrescine transport system, permease component I
PL14_RS06540	COG1177	transmembrane transport
PL14_RS06545	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
PL14_RS06555	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
PL14_RS06560	COG0004	ammonium transporteR
PL14_RS06565	COG0488	(ABC) transporter
PL14_RS06570	COG2197	response regulator
PL14_RS06580	COG2271	Major facilitator Superfamily
PL14_RS06585	COG1840	ABC-type Fe3 transport system, periplasmic component
PL14_RS06595	COG3842	ATPase activity
PL14_RS06600	COG0746	molybdenum cofactor guanylyltransferase activity
PL14_RS06605	COG1763	Mo-molybdopterin cofactor biosynthetic process
PL14_RS06615	COG1940	carbohydrate kinase activity
PL14_RS06620	COG3148	PFAM DTW domain containing protein
PL14_RS06630	COG0840	transmembrane signaling receptor activity
PL14_RS06635	COG0791	NLP P60 protein
PL14_RS06645	COG3001	Fructosamine kinase
PL14_RS06660	COG1793	dna ligase
PL14_RS06665	COG4667	esterase of the alpha-beta hydrolase superfamily
PL14_RS06680	COG0848	biopolymer transport protein
PL14_RS06685	COG0811	peptide transport
PL14_RS06690	COG0811	peptide transport
PL14_RS06720	COG0625	glutathione transferase activity
PL14_RS06730	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
PL14_RS06740	COG2195	Cleaves the N-terminal amino acid of tripeptides
PL14_RS06750	COG1115	amino acid carrier protein
PL14_RS06755	COG1280	lysine exporter protein (LysE YggA)
PL14_RS06760	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
PL14_RS06765	COG0477	Major facilitator Superfamily
PL14_RS06770	COG0583	DNA-binding transcription factor activity
PL14_RS06780	COG1643	Atp-dependent helicase
PL14_RS06800	COG3706	GGDEF domain
PL14_RS06815	COG0443	Heat shock 70 kDa protein
PL14_RS06845	COG1609	Transcriptional regulator
PL14_RS06850	COG2723	6-phospho-beta-galactosidase activity
PL14_RS06855	COG0513	Belongs to the DEAD box helicase family
PL14_RS06860	COG0243	molybdopterin cofactor binding
PL14_RS06865	COG3005	denitrification pathway
PL14_RS06870	COG1278	Cold shock
PL14_RS06880	COG4191	Histidine kinase
PL14_RS06880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PL14_RS06885	COG0471	metal ion transport
PL14_RS06895	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
PL14_RS06915	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PL14_RS06925	COG3768	UPF0283 membrane protein
PL14_RS06930	COG3106	COG3106 Predicted ATPase
PL14_RS06955	COG0814	amino acid
PL14_RS06960	COG1760	l-serine dehydratase
PL14_RS06970	COG2356	endonuclease I
PL14_RS06975	COG0720	synthase
PL14_RS06980	COG0840	transmembrane signaling receptor activity
PL14_RS06985	COG0017	Asparaginyl-tRNA synthetase
PL14_RS06995	COG2201	protein-glutamate methylesterase activity
PL14_RS07000	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
PL14_RS07005	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
PL14_RS07010	COG0835	chemotaxis
PL14_RS07020	COG0643	Histidine kinase
PL14_RS07020	COG2198	Histidine kinase
PL14_RS07030	COG0745	RESPONSE REGULATOR receiver
PL14_RS07035	COG0840	transmembrane signaling receptor activity
PL14_RS07040	COG2770	Histidine kinase
PL14_RS07040	COG3437	response regulator, receiver
PL14_RS07045	COG1448	Aminotransferase
PL14_RS07050	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
PL14_RS07060	COG0840	transmembrane signaling receptor activity
PL14_RS07065	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PL14_RS07070	COG1846	Transcriptional regulator
PL14_RS07085	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PL14_RS07090	COG3108	Peptidase M15
PL14_RS07095	COG2989	Protein conserved in bacteria
PL14_RS07125	COG1940	carbohydrate kinase activity
PL14_RS07135	COG0748	coenzyme F420 binding
PL14_RS07140	COG3721	Heme iron utilization protein
PL14_RS07145	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
PL14_RS07150	COG0811	peptide transport
PL14_RS07155	COG0848	biopolymer transport protein
PL14_RS07165	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PL14_RS07170	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
PL14_RS07175	COG1054	Belongs to the UPF0176 family
PL14_RS07190	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PL14_RS07200	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
PL14_RS07225	COG1621	beta-fructofuranosidase activity
PL14_RS07235	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PL14_RS07235	COG1263	PTS System
PL14_RS07240	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PL14_RS07245	COG2200	EAL domain
PL14_RS07250	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
PL14_RS07255	COG0840	transmembrane signaling receptor activity
PL14_RS07260	COG1294	oxidase, subunit
PL14_RS07265	COG1271	oxidase subunit
PL14_RS07290	COG3220	belongs to the UPF0276 family
PL14_RS07310	COG1294	oxidase, subunit
PL14_RS07320	COG0251	oxidation-reduction process
PL14_RS07355	COG2801	Transposase and inactivated derivatives
PL14_RS07385	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
PL14_RS07390	COG1012	belongs to the aldehyde dehydrogenase family
PL14_RS07410	COG5433	transposase activity
PL14_RS07415	COG3385	transposase activity
PL14_RS07450	COG0515	serine threonine protein kinase
PL14_RS07450	COG3064	Membrane
PL14_RS07450	COG4991	sh3 domain protein
PL14_RS07475	COG1716	ATPase activity
PL14_RS07495	COG1181	Belongs to the D-alanine--D-alanine ligase family
PL14_RS07570	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
PL14_RS07615	COG0784	Response regulator, receiver
PL14_RS07615	COG0835	chemotaxis
PL14_RS07625	COG4565	transcriptional regulatory protein
PL14_RS07630	COG3290	protein histidine kinase activity
PL14_RS07645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PL14_RS07670	COG3063	Type IV pilus biogenesis stability protein PilW
PL14_RS07685	COG1451	nucleotide metabolic process
PL14_RS07695	COG0583	DNA-binding transcription factor activity
PL14_RS07715	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
PL14_RS07720	COG4139	cobalamin transport
PL14_RS07725	COG2988	succinylglutamate desuccinylase activity
PL14_RS07740	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
PL14_RS07745	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
PL14_RS07750	COG1073	alpha beta
PL14_RS07750	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
PL14_RS07750	COG3064	Membrane
PL14_RS07755	COG2994	toxin metabolic process
PL14_RS07785	COG0702	epimerase
PL14_RS07790	COG1823	symporter activity
PL14_RS07795	COG2925	Exonuclease
PL14_RS07800	COG1380	Effector of murein hydrolase LrgA
PL14_RS07805	COG1346	cytolysis
PL14_RS07815	COG5001	Diguanylate cyclase
PL14_RS07815	COG3300	MHYT domain
PL14_RS07830	COG0500	methyltransferase
PL14_RS07840	COG0776	regulation of translation
PL14_RS07845	COG0072	phenylalanine-tRNA ligase activity
PL14_RS07845	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PL14_RS07850	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
PL14_RS07890	COG0322	excinuclease ABC activity
PL14_RS07895	COG2197	response regulator
PL14_RS07900	COG0417	DNA replication proofreading
PL14_RS07910	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
PL14_RS07915	COG3099	Belongs to the UPF0263 family
PL14_RS07920	COG3097	Belongs to the UPF0267 family
PL14_RS07930	COG1228	amidohydrolase
PL14_RS07935	COG0010	Belongs to the arginase family
PL14_RS07945	COG2986	histidine ammonia-lyase
PL14_RS07960	COG0247	lactate metabolic process
PL14_RS07960	COG0277	FAD linked oxidase domain protein
PL14_RS07990	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
PL14_RS07995	COG1960	acyl-CoA dehydrogenase activity
PL14_RS08020	COG5001	Diguanylate cyclase
PL14_RS08020	COG3300	MHYT domain
PL14_RS08040	COG5002	protein histidine kinase activity
PL14_RS08040	COG0784	Response regulator, receiver
PL14_RS08050	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
PL14_RS08055	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
PL14_RS08060	COG2885	chlorophyll binding
PL14_RS08065	COG0823	Involved in the tonB-independent uptake of proteins
PL14_RS08080	COG0811	peptide transport
PL14_RS08085	COG0824	Thioesterase
PL14_RS08090	COG3790	cyd operon protein YbgE
PL14_RS08095	COG4890	Cyd operon protein YbgT
PL14_RS08100	COG1294	oxidase, subunit
PL14_RS08105	COG1271	oxidase subunit
PL14_RS08110	COG2255	four-way junction helicase activity
PL14_RS08115	COG0632	four-way junction helicase activity
PL14_RS08120	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
PL14_RS08125	COG0215	cysteine-tRNA ligase activity
PL14_RS08130	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
PL14_RS08135	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PL14_RS08140	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
PL14_RS08145	COG3012	SEC-C Motif Domain Protein
PL14_RS08160	COG1199	ATP-dependent helicase activity
PL14_RS08170	COG3923	Primosomal replication protein n
PL14_RS08180	COG0840	transmembrane signaling receptor activity
PL14_RS08185	COG0708	Exodeoxyribonuclease III
PL14_RS08190	COG4160	amino acid transport
PL14_RS08220	COG1882	Formate acetyltransferase
PL14_RS08235	COG3335	DDE superfamily endonuclease
PL14_RS08245	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
PL14_RS08255	COG3013	Belongs to the UPF0304 family
PL14_RS08260	COG2766	serine protein kinase
PL14_RS08265	COG2718	Belongs to the UPF0229 family
PL14_RS08270	COG2719	SpoVR family
PL14_RS08275	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
PL14_RS08290	COG1132	(ABC) transporter
PL14_RS08295	COG2333	competence protein COMEC
PL14_RS08295	COG0658	competence protein
PL14_RS08305	COG4591	ABC-type transport system involved in lipoprotein release permease component
PL14_RS08310	COG1136	(ABC) transporter
PL14_RS08315	COG4591	ABC-type transport system involved in lipoprotein release permease component
PL14_RS08325	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
PL14_RS08340	COG1252	NADH dehydrogenase
PL14_RS08345	COG3150	esterase
PL14_RS08370	COG0537	adenosine 5'-monophosphoramidase activity
PL14_RS08385	COG2186	Transcriptional regulator
PL14_RS08390	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
PL14_RS08400	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
PL14_RS08405	COG2226	methyltransferase
PL14_RS08415	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
PL14_RS08420	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
PL14_RS08430	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
PL14_RS08435	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
PL14_RS08445	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PL14_RS08455	COG4120	Belongs to the binding-protein-dependent transport system permease family
PL14_RS08465	COG3092	negative regulation of chromosome organization
PL14_RS08470	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
PL14_RS08475	COG0280	phosphate acetyltransferase
PL14_RS08475	COG0857	belongs to the CobB CobQ family
PL14_RS08480	COG0435	Glutathione S-transferase
PL14_RS08490	COG0444	Belongs to the ABC transporter superfamily
PL14_RS08495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PL14_RS08500	COG0601	transmembrane transport
PL14_RS08515	COG5002	protein histidine kinase activity
PL14_RS08515	COG0784	Response regulator, receiver
PL14_RS08540	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PL14_RS08545	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PL14_RS08565	COG1215	transferase activity, transferring glycosyl groups
PL14_RS08600	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PL14_RS08605	COG1028	Short-chain dehydrogenase reductase Sdr
PL14_RS08625	COG3706	GGDEF domain
PL14_RS08635	COG0800	Aldolase
PL14_RS08640	COG2610	gluconate transmembrane transporter activity
PL14_RS08645	COG3265	gluconokinase activity
PL14_RS08650	COG0129	dihydroxy-acid dehydratase activity
PL14_RS08655	COG1609	Transcriptional regulator
PL14_RS08665	COG5002	protein histidine kinase activity
PL14_RS08665	COG2205	protein histidine kinase activity
PL14_RS08665	COG0784	Response regulator, receiver
PL14_RS08675	COG2985	domain, Protein
PL14_RS08690	COG2194	sulfuric ester hydrolase activity
PL14_RS08695	COG0642	Histidine kinase
PL14_RS08700	COG0745	RESPONSE REGULATOR receiver
PL14_RS08710	COG4221	oxidoreductase activity
PL14_RS08720	COG1022	Amp-dependent synthetase and ligase
PL14_RS08780	COG0732	type I restriction modification DNA specificity domain
PL14_RS08805	COG1061	Type III restriction enzyme res subunit
PL14_RS08840	COG3706	GGDEF domain
PL14_RS08855	COG3126	Type III secretion system lipoprotein chaperone (YscW)
PL14_RS08860	COG1946	Acyl-CoA thioesterase
PL14_RS08865	COG1522	sequence-specific DNA binding
PL14_RS08900	COG0318	PFAM AMP-dependent synthetase and ligase
PL14_RS08910	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
PL14_RS08920	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
PL14_RS08925	COG1169	isochorismate synthase
PL14_RS08930	COG0436	Aminotransferase
PL14_RS08935	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
PL14_RS08940	COG0232	Belongs to the dGTPase family. Type 2 subfamily
PL14_RS08955	COG0616	signal peptide processing
PL14_RS08960	COG1028	Short-chain dehydrogenase reductase Sdr
PL14_RS08965	COG0835	chemotaxis
PL14_RS08965	COG0784	Response regulator, receiver
PL14_RS08970	COG1940	carbohydrate kinase activity
PL14_RS08980	COG4667	esterase of the alpha-beta hydrolase superfamily
PL14_RS08990	COG0733	neurotransmitter:sodium symporter activity
PL14_RS08995	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PL14_RS08995	COG1263	PTS System
PL14_RS09000	COG0084	hydrolase, TatD family'
PL14_RS09005	COG0470	DNA polymerase III
PL14_RS09010	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
PL14_RS09015	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
PL14_RS09020	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
PL14_RS09045	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PL14_RS09060	COG1399	metal-binding, possibly nucleic acid-binding protein
PL14_RS09065	COG0424	maF-like protein
PL14_RS09070	COG0564	pseudouridine synthase activity
PL14_RS09075	COG1530	ribonuclease E activity
PL14_RS09085	COG1454	alcohol dehydrogenase
PL14_RS09085	COG1012	belongs to the aldehyde dehydrogenase family
PL14_RS09090	COG2095	MarC family integral membrane protein
PL14_RS09095	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
PL14_RS09100	COG1757	Na H antiporter
PL14_RS09115	COG3082	Protein of unknown function (DUF1414)
PL14_RS09130	COG0243	molybdopterin cofactor binding
PL14_RS09135	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
PL14_RS09150	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
PL14_RS09155	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
PL14_RS09175	COG2853	Lipoprotein
PL14_RS09190	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PL14_RS09195	COG1138	Cytochrome C-type biogenesis protein
PL14_RS09200	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
PL14_RS09210	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
PL14_RS09215	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
PL14_RS09220	COG4133	protoheme IX ABC transporter activity
PL14_RS09230	COG0835	chemotaxis
PL14_RS09240	COG1192	Involved in chromosome partitioning
PL14_RS09245	COG2201	protein-glutamate methylesterase activity
PL14_RS09250	COG0643	Histidine kinase
PL14_RS09250	COG0784	Response regulator, receiver
PL14_RS09250	COG2198	Histidine kinase
PL14_RS09255	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
PL14_RS09280	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
PL14_RS09285	COG2062	phosphohistidine phosphatase, SixA
PL14_RS09290	COG1025	Belongs to the peptidase M16 family
PL14_RS09295	COG3102	Protein conserved in bacteria
PL14_RS09320	COG1918	ferrous iron import across plasma membrane
PL14_RS09325	COG4977	sequence-specific DNA binding
PL14_RS09330	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
PL14_RS09335	COG1121	(ABC) transporter
PL14_RS09340	COG1108	ABC-type Mn2 Zn2 transport systems permease components
PL14_RS09355	COG0508	dehydrogenase complex catalyzes the overall conversion of
PL14_RS09360	COG0567	Dehydrogenase, E1 component
PL14_RS09375	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
PL14_RS09390	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
PL14_RS09400	COG0033	Phosphoglucomutase
PL14_RS09405	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
PL14_RS09410	COG0596	Alpha beta hydrolase
PL14_RS09425	COG1346	cytolysis
PL14_RS09435	COG0583	DNA-binding transcription factor activity
PL14_RS09445	COG0735	belongs to the Fur family
PL14_RS09450	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
PL14_RS09455	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PL14_RS09460	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PL14_RS09465	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
PL14_RS09465	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PL14_RS09470	COG0431	NADPH-dependent FMN reductase
PL14_RS09480	COG3101	peptidyl-lysine hydroxylation
PL14_RS09485	COG2860	membrane
PL14_RS09490	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
PL14_RS09495	COG2890	protein-(glutamine-N5) methyltransferase activity
PL14_RS09500	COG2840	Smr protein MutS2
PL14_RS09510	COG1684	flagellar biosynthetic protein fliR
PL14_RS09515	COG1987	bacterial-type flagellum assembly
PL14_RS09565	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
PL14_RS09575	COG1677	Flagellar hook-basal body complex protein FliE
PL14_RS09595	COG1516	flagellar protein fliS
PL14_RS09605	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
PL14_RS09630	COG2837	iron assimilation
PL14_RS09655	COG1393	Belongs to the ArsC family
PL14_RS09675	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
PL14_RS09690	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
PL14_RS09715	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
PL14_RS09770	COG4783	chaperone-mediated protein folding
PL14_RS09775	COG1393	Belongs to the ArsC family
PL14_RS09795	COG2233	PERMEase
PL14_RS09800	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
PL14_RS09810	COG2877	3-deoxy-8-phosphooctulonate synthase activity
PL14_RS09815	COG2912	Transglutaminase-like superfamily
PL14_RS09820	COG3094	Invasion gene expression up-regulator, SirB
PL14_RS09825	COG2890	protein-(glutamine-N5) methyltransferase activity
PL14_RS09830	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
PL14_RS09835	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
PL14_RS09840	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
PL14_RS09845	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
PL14_RS09850	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
PL14_RS09855	COG0193	aminoacyl-tRNA hydrolase activity
PL14_RS09955	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
PL14_RS09965	COG3951	Flagellar rod assembly protein muramidase FlgJ
PL14_RS09965	COG1705	Flagellar rod assembly protein muramidase FlgJ
PL14_RS09970	COG1706	bacterial-type flagellum-dependent cell motility
PL14_RS09975	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
PL14_RS09985	COG4787	bacterial-type flagellum-dependent cell motility
PL14_RS09990	COG1749	Flagellar hook protein flgE
PL14_RS10005	COG1815	bacterial-type flagellum-dependent cell motility
PL14_RS10015	COG0784	Response regulator, receiver
PL14_RS10015	COG0835	chemotaxis
PL14_RS10025	COG2747	anti-sigma28 factor FlgM
PL14_RS10070	COG2608	mercury ion transmembrane transporter activity
PL14_RS10070	COG2217	Heavy metal translocating P-type atpase
PL14_RS10095	COG1187	pseudouridine synthase activity
PL14_RS10100	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
PL14_RS10105	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
PL14_RS10110	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
PL14_RS10115	COG0121	glutamine amidotransferase
PL14_RS10120	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
PL14_RS10140	COG0328	RNA-DNA hybrid ribonuclease activity
PL14_RS10145	COG2226	methyltransferase
PL14_RS10150	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PL14_RS10155	COG0741	lytic transglycosylase activity
PL14_RS10155	COG1388	LysM domain
PL14_RS10165	COG3021	interspecies interaction between organisms
PL14_RS10170	COG0347	Belongs to the P(II) protein family
PL14_RS10180	COG0037	tRNA processing
PL14_RS10185	COG0825	malonyl-CoA metabolic process
PL14_RS10190	COG0587	DNA-directed DNA polymerase activity
PL14_RS10200	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PL14_RS10210	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PL14_RS10215	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PL14_RS10220	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
PL14_RS10230	COG0750	zinc metalloprotease
PL14_RS10235	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
PL14_RS10240	COG0575	Belongs to the CDS family
PL14_RS10245	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
PL14_RS10250	COG0233	cytoplasmic translational termination
PL14_RS10260	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
PL14_RS10265	COG0052	Belongs to the universal ribosomal protein uS2 family
PL14_RS10270	COG0024	Methionine aminopeptidase
PL14_RS10275	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
PL14_RS10285	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
PL14_RS10290	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
PL14_RS10295	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PL14_RS10315	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PL14_RS10315	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PL14_RS10320	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
PL14_RS10325	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
PL14_RS10330	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
PL14_RS10340	COG1073	alpha beta
PL14_RS10345	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
PL14_RS10350	COG2252	PERMEase
PL14_RS10355	COG2195	Cleaves the N-terminal amino acid of tripeptides
PL14_RS10360	COG0189	ligase activity
PL14_RS10360	COG4067	protein conserved in archaea
PL14_RS10365	COG0189	ligase activity
PL14_RS10375	COG0733	neurotransmitter:sodium symporter activity
PL14_RS10380	COG2203	Gaf domain
PL14_RS10380	COG3706	GGDEF domain
PL14_RS10380	COG5001	Diguanylate cyclase
PL14_RS10380	COG4251	negative regulation of phosphorylation
PL14_RS10390	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
PL14_RS10400	COG1477	protein flavinylation
PL14_RS10435	COG0271	Belongs to the BolA IbaG family
PL14_RS10455	COG2211	Major facilitator Superfamily
PL14_RS10465	COG1595	DNA-templated transcription, initiation
PL14_RS10480	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
PL14_RS10490	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
PL14_RS10495	COG2166	iron-sulfur cluster assembly
PL14_RS10500	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
PL14_RS10505	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
PL14_RS10515	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
PL14_RS10515	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
PL14_RS10525	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
PL14_RS10530	COG1074	ATP-dependent DNA helicase activity
PL14_RS10535	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
PL14_RS10550	COG3141	response to X-ray
PL14_RS10555	COG2171	N-acyltransferase activity
PL14_RS10585	COG1609	Transcriptional regulator
PL14_RS10595	COG1085	galactose-1-phosphate uridylyltransferase
PL14_RS10600	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
PL14_RS10605	COG0534	Mate efflux family protein
PL14_RS10615	COG3437	response regulator, receiver
PL14_RS10615	COG0784	Response regulator, receiver
PL14_RS10625	COG4628	conserved protein (DUF2132)
PL14_RS10630	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
PL14_RS10635	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
PL14_RS10645	COG0560	Phosphoserine phosphatase
PL14_RS10655	COG0813	purine-nucleoside phosphorylase activity
PL14_RS10660	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
PL14_RS10665	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
PL14_RS10670	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
PL14_RS10675	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
PL14_RS10680	COG0084	hydrolase, TatD family'
PL14_RS10685	COG3022	response to hydroperoxide
PL14_RS10690	COG1115	amino acid carrier protein
PL14_RS10705	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
PL14_RS10710	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
PL14_RS10715	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
PL14_RS10720	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
PL14_RS10725	COG0083	homoserine kinase activity
PL14_RS10740	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
PL14_RS10745	COG0745	RESPONSE REGULATOR receiver
PL14_RS10755	COG0784	Response regulator, receiver
PL14_RS10755	COG2198	Histidine kinase
PL14_RS10755	COG5002	protein histidine kinase activity
PL14_RS10760	COG1242	4 iron, 4 sulfur cluster binding
PL14_RS10765	COG0067	glutamate synthase
PL14_RS10765	COG0069	glutamate synthase activity
PL14_RS10765	COG0070	glutamate synthase
PL14_RS10775	COG0069	glutamate synthase activity
PL14_RS10775	COG0070	glutamate synthase
PL14_RS10775	COG0067	glutamate synthase
PL14_RS10780	COG0493	'glutamate synthase
PL14_RS10790	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
PL14_RS10800	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PL14_RS10805	COG2860	membrane
PL14_RS10810	COG0583	DNA-binding transcription factor activity
PL14_RS10815	COG0730	response to heat
PL14_RS10820	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
PL14_RS10825	COG0505	Belongs to the CarA family
PL14_RS10830	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
PL14_RS10835	COG0494	nUDIX hydrolase
PL14_RS10840	COG0653	protein targeting
PL14_RS10850	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
PL14_RS10855	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
PL14_RS10860	COG0849	cell division
PL14_RS10865	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
PL14_RS10870	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
PL14_RS10875	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
PL14_RS10880	COG0772	Belongs to the SEDS family
PL14_RS10885	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
PL14_RS10895	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
PL14_RS10900	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
PL14_RS10905	COG0768	penicillin binding
PL14_RS10910	COG3116	cell division
PL14_RS10915	COG0275	rRNA processing
PL14_RS10925	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
PL14_RS10930	COG3107	peptidoglycan biosynthetic process
PL14_RS10935	COG0792	nuclease activity
PL14_RS10940	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
PL14_RS10950	COG2969	positive regulation of protein catabolic process
PL14_RS10955	COG0625	glutathione transferase activity
PL14_RS10960	COG2857	Cytochrome c1
PL14_RS10965	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
PL14_RS10970	COG0723	plastoquinol--plastocyanin reductase activity
PL14_RS10980	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
PL14_RS10990	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
PL14_RS10995	COG3105	Protein conserved in bacteria
PL14_RS11000	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PL14_RS11005	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PL14_RS11010	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
PL14_RS11015	COG0187	DNA topoisomerase II activity
PL14_RS11020	COG3150	esterase
PL14_RS11030	COG3151	Protein conserved in bacteria
PL14_RS11035	COG0494	nUDIX hydrolase
PL14_RS11040	COG1538	Outer membrane efflux protein
PL14_RS11050	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
PL14_RS11065	COG3025	triphosphatase activity
PL14_RS11070	COG1392	Phosphate transport regulator
PL14_RS11075	COG0306	phosphate transporter
PL14_RS11080	COG4991	sh3 domain protein
PL14_RS11090	COG3409	Peptidoglycan-binding domain 1 protein
PL14_RS11090	COG3267	Type II secretory pathway component ExeA
PL14_RS11095	COG0617	tRNA 3'-terminal CCA addition
PL14_RS11105	COG0504	CTP synthase activity
PL14_RS11110	COG3956	TIGRFAM MazG family protein
PL14_RS11115	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PL14_RS11120	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PL14_RS11125	COG4999	Histidine kinase
PL14_RS11125	COG3850	Histidine kinase
PL14_RS11125	COG3437	response regulator, receiver
PL14_RS11125	COG2205	protein histidine kinase activity
PL14_RS11130	COG0736	holo-[acyl-carrier-protein] synthase activity
PL14_RS11135	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
PL14_RS11140	COG1381	Involved in DNA repair and RecF pathway recombination
PL14_RS11145	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
PL14_RS11150	COG0571	ribonuclease III activity
PL14_RS11160	COG0481	GTPase activity
PL14_RS11165	COG3086	response to oxidative stress
PL14_RS11180	COG1595	DNA-templated transcription, initiation
PL14_RS11185	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
PL14_RS11195	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
PL14_RS11215	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PL14_RS11220	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PL14_RS11225	COG3079	Belongs to the UPF0149 family
PL14_RS11230	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
PL14_RS11240	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
PL14_RS11250	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PL14_RS11260	COG0028	Belongs to the TPP enzyme family
PL14_RS11265	COG1022	Amp-dependent synthetase and ligase
PL14_RS11270	COG0583	DNA-binding transcription factor activity
PL14_RS11290	COG0473	3-isopropylmalate dehydrogenase activity
PL14_RS11300	COG0066	3-isopropylmalate dehydratase activity
PL14_RS11355	COG0795	lipopolysaccharide-transporting ATPase activity
PL14_RS11360	COG0795	lipopolysaccharide-transporting ATPase activity
PL14_RS11365	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
PL14_RS11370	COG2927	DNA polymerase III (CHI subunit)
PL14_RS11375	COG0525	valine-tRNA ligase activity
PL14_RS11380	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PL14_RS11385	COG0564	pseudouridine synthase activity
PL14_RS11395	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
PL14_RS11400	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
PL14_RS11415	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
PL14_RS11420	COG0251	oxidation-reduction process
PL14_RS11435	COG0204	Acyl-transferase
PL14_RS11440	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
PL14_RS11445	COG5007	Belongs to the BolA IbaG family
PL14_RS11455	COG2854	intermembrane phospholipid transfer
PL14_RS11460	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
PL14_RS11465	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
PL14_RS11470	COG1127	ABC transporter
PL14_RS11480	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
PL14_RS11480	COG0517	IMP dehydrogenase activity
PL14_RS11495	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
PL14_RS11500	COG1137	ATPase activity
PL14_RS11510	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
PL14_RS11515	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
PL14_RS11520	COG1660	Displays ATPase and GTPase activities
PL14_RS11525	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
PL14_RS11530	COG2239	Acts as a magnesium transporter
PL14_RS11535	COG0312	modulator of DNA gyrase
PL14_RS11540	COG3028	Belongs to the UPF0307 family
PL14_RS11545	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
PL14_RS11550	COG1178	ABC-type Fe3 transport system permease component
PL14_RS11560	COG0163	prenyltransferase activity
PL14_RS11565	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
PL14_RS11570	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
PL14_RS11575	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
PL14_RS11580	COG2105	PFAM AIG2 family protein
PL14_RS11585	COG2911	Protein conserved in bacteria
PL14_RS11590	COG0729	surface antigen
PL14_RS11595	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PL14_RS11600	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
PL14_RS11635	COG0529	Catalyzes the synthesis of activated sulfate
PL14_RS11640	COG2895	sulfate adenylyltransferase (ATP) activity
PL14_RS11645	COG0175	sulfate reduction
PL14_RS11650	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
PL14_RS11650	COG1648	precorrin-2 dehydrogenase activity
PL14_RS11655	COG0737	Belongs to the 5'-nucleotidase family
PL14_RS11695	COG0513	Belongs to the DEAD box helicase family
PL14_RS11700	COG2153	protein acetylation
PL14_RS11705	COG3061	Opacity-associated protein A
PL14_RS11705	COG3266	domain, Protein
PL14_RS11710	COG0545	Peptidyl-prolyl cis-trans isomerase
PL14_RS11715	COG0203	ribosomal protein L17
PL14_RS11720	COG0202	RNA polymerase activity
PL14_RS11725	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
PL14_RS11730	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
PL14_RS11735	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
PL14_RS11740	COG0257	Belongs to the bacterial ribosomal protein bL36 family
PL14_RS11745	COG0201	protein transport
PL14_RS11750	COG0200	Binds to the 23S rRNA
PL14_RS11755	COG1841	ribosomal large subunit assembly
PL14_RS11760	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
PL14_RS11770	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
PL14_RS11775	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
PL14_RS11780	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
PL14_RS11785	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
PL14_RS11790	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
PL14_RS11800	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
PL14_RS11810	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
PL14_RS11825	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
PL14_RS11830	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
PL14_RS11840	COG0088	Forms part of the polypeptide exit tunnel
PL14_RS11845	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
PL14_RS11850	COG0051	transcription antitermination factor activity, RNA binding
PL14_RS11855	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PL14_RS11860	COG0557	exoribonuclease II activity
PL14_RS11865	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
PL14_RS11870	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
PL14_RS11880	COG1047	Peptidyl-prolyl cis-trans
PL14_RS11885	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
PL14_RS11895	COG2249	NAD(P)H dehydrogenase (quinone) activity
PL14_RS11900	COG0488	(ABC) transporter
PL14_RS11910	COG0429	hydrolase of the alpha beta-hydrolase fold
PL14_RS11920	COG3954	Phosphoribulokinase
PL14_RS11925	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PL14_RS11935	COG1012	belongs to the aldehyde dehydrogenase family
PL14_RS11945	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PL14_RS11970	COG3335	DDE superfamily endonuclease
PL14_RS11985	COG5433	transposase activity
PL14_RS11995	COG5433	transposase activity
PL14_RS12020	COG5433	transposase activity
PL14_RS12030	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PL14_RS12040	COG0583	DNA-binding transcription factor activity
PL14_RS12055	COG0180	Tryptophanyl-tRNA synthetase
PL14_RS12060	COG0546	phosphoglycolate phosphatase activity
PL14_RS12065	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
PL14_RS12070	COG0338	D12 class N6 adenine-specific DNA methyltransferase
PL14_RS12080	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
PL14_RS12085	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
PL14_RS12115	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
PL14_RS12120	COG3385	transposase activity
PL14_RS12130	COG0678	peroxiredoxin activity
PL14_RS12130	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
PL14_RS12135	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PL14_RS12145	COG0165	Argininosuccinate lyase
PL14_RS12145	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
PL14_RS12150	COG0137	argininosuccinate synthase activity
PL14_RS12155	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
PL14_RS12160	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
PL14_RS12165	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PL14_RS12170	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
PL14_RS12180	COG1045	serine acetyltransferase
PL14_RS12185	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
PL14_RS12195	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PL14_RS12200	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
PL14_RS12205	COG1053	succinate dehydrogenase
PL14_RS12210	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
PL14_RS12215	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
PL14_RS12225	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
PL14_RS12230	COG1509	lysine 2,3-aminomutase activity
PL14_RS12245	COG0459	protein refolding
PL14_RS12250	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
PL14_RS12280	COG0534	Mate efflux family protein
PL14_RS12285	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
PL14_RS12290	COG1575	Belongs to the MenA family. Type 1 subfamily
PL14_RS12300	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
PL14_RS12310	COG1609	Transcriptional regulator
PL14_RS12315	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
PL14_RS12325	COG0281	malic enzyme
PL14_RS12330	COG3385	transposase activity
PL14_RS12340	COG0626	cystathionine gamma-synthase activity
PL14_RS12345	COG0527	aspartate kinase activity
PL14_RS12345	COG0460	homoserine dehydrogenase
PL14_RS12350	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
PL14_RS12355	COG3074	FtsZ-dependent cytokinesis
PL14_RS12360	COG1494	fructose-1,6-bisphosphatase
PL14_RS12365	COG0205	6-phosphofructokinase activity
PL14_RS12370	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
PL14_RS12380	COG0745	RESPONSE REGULATOR receiver
PL14_RS12385	COG2205	protein histidine kinase activity
PL14_RS12390	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
PL14_RS12395	COG1278	Cold shock
PL14_RS12400	COG3030	protein affecting phage T7 exclusion by the F plasmid
PL14_RS12410	COG1027	Aspartate ammonia-lyase
PL14_RS12415	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
PL14_RS12420	COG1288	antiporter activity
PL14_RS12430	COG0549	Belongs to the carbamate kinase family
PL14_RS12435	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
PL14_RS12445	COG0540	Belongs to the ATCase OTCase family
PL14_RS12450	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
PL14_RS12455	COG1438	arginine binding
PL14_RS12460	COG4232	protein-disulfide reductase activity
PL14_RS12480	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PL14_RS12485	COG0784	Response regulator, receiver
PL14_RS12485	COG2198	Histidine kinase
PL14_RS12485	COG2205	protein histidine kinase activity
PL14_RS12490	COG2814	Major facilitator Superfamily
PL14_RS12505	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PL14_RS12510	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
PL14_RS12515	COG0511	ligase activity, forming carbon-carbon bonds
PL14_RS12520	COG0439	Biotin carboxylase
PL14_RS12525	COG2264	protein methyltransferase activity
PL14_RS12530	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PL14_RS12535	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
PL14_RS12545	COG1982	Orn Lys Arg decarboxylase major
PL14_RS12550	COG0531	amino acid
PL14_RS12555	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
PL14_RS12560	COG3710	Transcriptional regulator
PL14_RS12565	COG0789	Transcriptional regulator
PL14_RS12570	COG0138	bifunctional purine biosynthesis protein purh
PL14_RS12575	COG0151	Belongs to the GarS family
PL14_RS12585	COG0776	regulation of translation
PL14_RS12590	COG1253	flavin adenine dinucleotide binding
PL14_RS12595	COG2852	Protein conserved in bacteria
PL14_RS12605	COG3068	Protein conserved in bacteria
PL14_RS12610	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PL14_RS12615	COG0668	transmembrane transport
PL14_RS12620	COG0840	transmembrane signaling receptor activity
PL14_RS12625	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
PL14_RS12630	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PL14_RS12635	COG5433	transposase activity
PL14_RS12640	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PL14_RS12645	COG5433	transposase activity
PL14_RS12665	COG1216	Glycosyl transferase, family 2
PL14_RS12680	COG1215	transferase activity, transferring glycosyl groups
PL14_RS12695	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PL14_RS12720	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PL14_RS12730	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
PL14_RS12755	COG3754	Rhamnan synthesis protein F
PL14_RS12800	COG0028	Belongs to the TPP enzyme family
PL14_RS12810	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PL14_RS12865	COG1682	transport, permease protein
PL14_RS12900	COG3307	-O-antigen
PL14_RS12905	COG0859	PFAM glycosyl transferase family 9
PL14_RS12920	COG1519	Transferase
PL14_RS12930	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
PL14_RS12945	COG3642	lipopolysaccharide core region biosynthetic process
PL14_RS12950	COG0859	PFAM glycosyl transferase family 9
PL14_RS12955	COG0463	Glycosyl transferase, family 2
PL14_RS12960	COG0859	PFAM glycosyl transferase family 9
PL14_RS12965	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
PL14_RS12970	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
PL14_RS12980	COG0267	Belongs to the bacterial ribosomal protein bL33 family
PL14_RS12985	COG0227	Belongs to the bacterial ribosomal protein bL28 family
PL14_RS12990	COG2003	Belongs to the UPF0758 family
PL14_RS12995	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
PL14_RS13000	COG1309	transcriptional regulator
PL14_RS13005	COG1560	Kdo2-lipid A biosynthetic process
PL14_RS13010	COG1560	Kdo2-lipid A biosynthetic process
PL14_RS13015	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
PL14_RS13020	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
PL14_RS13025	COG1561	YicC-like family, N-terminal region
PL14_RS13035	COG0612	Peptidase, M16
PL14_RS13040	COG2862	Uncharacterized protein family, UPF0114
PL14_RS13045	COG1028	Short-chain dehydrogenase reductase Sdr
PL14_RS13060	COG1263	PTS System
PL14_RS13060	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PL14_RS13065	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
PL14_RS13085	COG0514	ATP-dependent DNA helicase (RecQ)
PL14_RS13090	COG2962	Rard protein
PL14_RS13095	COG0405	Gamma-glutamyltransferase
PL14_RS13105	COG1280	lysine exporter protein (LysE YggA)
PL14_RS13110	COG0210	DNA helicase
PL14_RS13115	COG0339	signal peptide processing
PL14_RS13120	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
PL14_RS13125	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PL14_RS13145	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PL14_RS13150	COG0601	transmembrane transport
PL14_RS13200	COG1309	transcriptional regulator
PL14_RS13205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PL14_RS13210	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PL14_RS13215	COG2960	long-chain fatty acid transporting porin activity
PL14_RS13220	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
PL14_RS13230	COG0635	Involved in the biosynthesis of porphyrin-containing compound
PL14_RS13240	COG3078	GTPase activator activity
PL14_RS13260	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PL14_RS13260	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PL14_RS13270	COG0084	hydrolase, TatD family'
PL14_RS13275	COG0805	protein transport
PL14_RS13280	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PL14_RS13285	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PL14_RS13290	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
PL14_RS13300	COG2226	methyltransferase
PL14_RS13305	COG1322	Protein conserved in bacteria
PL14_RS13310	COG0697	spore germination
PL14_RS13330	COG3547	Transposase (IS116 IS110 IS902 family)
PL14_RS13345	COG5433	transposase activity
PL14_RS13395	COG2081	HI0933 family
PL14_RS13410	COG1528	Iron-storage protein
PL14_RS13415	COG0589	response to stress
PL14_RS13430	COG0742	ribosomal rna small subunit methyltransferase
PL14_RS13435	COG1522	sequence-specific DNA binding
PL14_RS13455	COG0006	proline dipeptidase activity
PL14_RS13455	COG0006	proline dipeptidase activity
PL14_RS13460	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
PL14_RS13465	COG2022	thiamine diphosphate biosynthetic process
PL14_RS13470	COG2104	thiamine diphosphate biosynthetic process
PL14_RS13480	COG0352	thiamine-phosphate diphosphorylase activity
PL14_RS13560	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
PL14_RS13565	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
PL14_RS13570	COG1739	Uncharacterized protein family UPF0029
PL14_RS13580	COG0183	Belongs to the thiolase family
PL14_RS13585	COG0583	DNA-binding transcription factor activity
PL14_RS13590	COG2814	Major facilitator Superfamily
PL14_RS13595	COG3385	transposase activity
PL14_RS13605	COG0355	proton-transporting ATP synthase activity, rotational mechanism
PL14_RS13610	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
PL14_RS13615	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
PL14_RS13620	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
PL14_RS13625	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
PL14_RS13630	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
PL14_RS13645	COG3312	ion transport
PL14_RS13650	COG1475	DNA binding
PL14_RS13655	COG1192	Involved in chromosome partitioning
PL14_RS13665	COG0445	tRNA wobble uridine modification
PL14_RS13670	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
PL14_RS13680	COG0706	membrane insertase activity
PL14_RS13695	COG1126	abc transporter atp-binding protein
PL14_RS13785	COG0751	glycine-tRNA ligase activity
PL14_RS14105	COG0019	diaminopimelate decarboxylase activity
PL14_RS14120	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
PL14_RS14370	COG3250	beta-galactosidase activity
PL14_RS14595	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PL14_RS14785	COG0085	RNA polymerase activity
PL14_RS15145	COG1410	methionine synthase
PL14_RS15145	COG0646	methionine synthase
PL14_RS15150	COG0646	methionine synthase
PL14_RS15150	COG1410	methionine synthase
PL14_RS15710	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
PL14_RS15940	COG0659	secondary active sulfate transmembrane transporter activity
PL14_RS15950	COG1131	(ABC) transporter
PL14_RS15980	COG0617	tRNA 3'-terminal CCA addition
PL14_RS16150	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PL14_RS16275	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PL14_RS16295	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
PL14_RS16645	COG3142	Participates in the control of copper homeostasis
PL14_RS16870	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
PL14_RS17195	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
PL14_RS17195	COG0047	phosphoribosylformylglycinamidine synthase activity
PL14_RS17255	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
PL14_RS17495	COG0489	protein tyrosine kinase activity
PL14_RS17690	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PL14_RS18115	COG0616	signal peptide processing
PL14_RS18140	COG1199	ATP-dependent helicase activity
PL14_RS18160	COG0318	PFAM AMP-dependent synthetase and ligase
PL14_RS18210	COG3325	Belongs to the glycosyl hydrolase 18 family
PL14_RS18210	COG3469	chitinase activity
PL14_RS18435	COG0539	negative regulation of cytoplasmic translation
PL14_RS18500	COG1674	ftsk spoiiie
PL14_RS18605	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
PL14_RS18760	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
PL14_RS18925	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
PL14_RS19015	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
PL14_RS19030	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
PL14_RS19110	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
PL14_RS19130	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division