locus-tag	class	description
CEJ46_RS00005	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CEJ46_RS00015	COG0706	membrane insertase activity
CEJ46_RS00035	COG1126	abc transporter atp-binding protein
CEJ46_RS00055	COG0592	DNA-directed DNA polymerase activity
CEJ46_RS00060	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CEJ46_RS00065	COG0187	DNA topoisomerase II activity
CEJ46_RS00080	COG0071	Belongs to the small heat shock protein (HSP20) family
CEJ46_RS00085	COG3977	Valine--pyruvate aminotransferase
CEJ46_RS00095	COG0752	glycyl-tRNA synthetase alpha subunit
CEJ46_RS00100	COG2119	membrane
CEJ46_RS00110	COG0425	Belongs to the sulfur carrier protein TusA family
CEJ46_RS00125	COG0604	alcohol dehydrogenase
CEJ46_RS00140	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CEJ46_RS00145	COG3978	acetolactate synthase activity
CEJ46_RS00155	COG0606	chelatase, subunit chli
CEJ46_RS00180	COG0840	transmembrane signaling receptor activity
CEJ46_RS00185	COG0840	transmembrane signaling receptor activity
CEJ46_RS00195	COG3335	DDE superfamily endonuclease
CEJ46_RS00215	COG3344	reverse transcriptase
CEJ46_RS00225	COG0606	chelatase, subunit chli
CEJ46_RS00235	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CEJ46_RS00240	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CEJ46_RS00255	COG3084	Protein conserved in bacteria
CEJ46_RS00265	COG1272	protein, Hemolysin III
CEJ46_RS00275	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CEJ46_RS00280	COG0569	domain protein
CEJ46_RS00285	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CEJ46_RS00285	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CEJ46_RS00290	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CEJ46_RS00295	COG0242	peptide deformylase activity
CEJ46_RS00300	COG1652	LysM domain
CEJ46_RS00305	COG0758	DNA mediated transformation
CEJ46_RS00310	COG2922	Belongs to the Smg family
CEJ46_RS00315	COG0551	DNA topoisomerase type I activity
CEJ46_RS00325	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CEJ46_RS00330	COG0009	L-threonylcarbamoyladenylate synthase
CEJ46_RS00335	COG0408	coproporphyrinogen oxidase activity
CEJ46_RS00340	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CEJ46_RS00350	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CEJ46_RS00395	COG3071	HemY protein
CEJ46_RS00400	COG2959	enzyme of heme biosynthesis
CEJ46_RS00405	COG1587	Uroporphyrinogen-III synthase
CEJ46_RS00430	COG0019	diaminopimelate decarboxylase activity
CEJ46_RS00435	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CEJ46_RS00445	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CEJ46_RS00450	COG1011	Hydrolase
CEJ46_RS00455	COG3148	PFAM DTW domain containing protein
CEJ46_RS00465	COG0561	phosphatase activity
CEJ46_RS00470	COG2267	carboxylic ester hydrolase activity
CEJ46_RS00475	COG1280	lysine exporter protein (LysE YggA)
CEJ46_RS00480	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
CEJ46_RS00485	COG0783	Belongs to the Dps family
CEJ46_RS00515	COG2095	MarC family integral membrane protein
CEJ46_RS00525	COG0742	ribosomal rna small subunit methyltransferase
CEJ46_RS00530	COG0552	protein localization to endoplasmic reticulum
CEJ46_RS00535	COG2884	Cell division ATP-binding protein ftsE
CEJ46_RS00540	COG2177	Part of the ABC transporter FtsEX involved in
CEJ46_RS00545	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CEJ46_RS00555	COG0705	Rhomboid family
CEJ46_RS00560	COG1580	Controls the rotational direction of flagella during chemotaxis
CEJ46_RS00565	COG3161	chorismate lyase activity
CEJ46_RS00575	COG2937	Belongs to the GPAT DAPAT family
CEJ46_RS00580	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CEJ46_RS00590	COG0534	Mate efflux family protein
CEJ46_RS00595	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CEJ46_RS00610	COG3250	beta-galactosidase activity
CEJ46_RS00635	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CEJ46_RS00710	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CEJ46_RS00715	COG3300	MHYT domain
CEJ46_RS00715	COG5001	Diguanylate cyclase
CEJ46_RS00725	COG3852	Histidine kinase
CEJ46_RS00735	COG0174	glutamine synthetase
CEJ46_RS00740	COG1217	gtp-binding protein TYPA
CEJ46_RS00745	COG1295	ribonuclease BN
CEJ46_RS00750	COG1490	D-aminoacyl-tRNA deacylase activity
CEJ46_RS00755	COG0456	acetyltransferase
CEJ46_RS00765	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CEJ46_RS00770	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CEJ46_RS00775	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CEJ46_RS00780	COG3031	protein transport across the cell outer membrane
CEJ46_RS00790	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CEJ46_RS00795	COG1459	type II secretion system
CEJ46_RS00800	COG2165	general secretion pathway protein
CEJ46_RS00805	COG2165	general secretion pathway protein
CEJ46_RS00810	COG2165	general secretion pathway protein
CEJ46_RS00815	COG4795	General secretion pathway protein
CEJ46_RS00820	COG3156	type II secretion system protein K
CEJ46_RS00825	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
CEJ46_RS00830	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
CEJ46_RS00840	COG1218	3'(2'),5'-bisphosphate nucleotidase
CEJ46_RS00845	COG0494	nUDIX hydrolase
CEJ46_RS00850	COG0316	Belongs to the HesB IscA family
CEJ46_RS00850	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CEJ46_RS00855	COG1040	competence protein
CEJ46_RS00860	COG0596	Alpha beta hydrolase
CEJ46_RS00870	COG2183	response to ionizing radiation
CEJ46_RS00875	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CEJ46_RS00895	COG0583	DNA-binding transcription factor activity
CEJ46_RS00925	COG2233	PERMEase
CEJ46_RS00930	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CEJ46_RS00935	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CEJ46_RS00940	COG1758	RNA polymerase activity
CEJ46_RS00945	COG0194	GDP metabolic process
CEJ46_RS00950	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CEJ46_RS00955	COG0248	Ppx GppA phosphatase
CEJ46_RS00965	COG3118	belongs to the thioredoxin family
CEJ46_RS00980	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CEJ46_RS01030	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CEJ46_RS01040	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CEJ46_RS01045	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CEJ46_RS01045	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CEJ46_RS01050	COG1072	(Pantothenic acid kinase))
CEJ46_RS01075	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CEJ46_RS01080	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CEJ46_RS01085	COG0250	Participates in transcription elongation, termination and antitermination
CEJ46_RS01100	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CEJ46_RS01105	COG0222	ribosome binding
CEJ46_RS01110	COG0085	RNA polymerase activity
CEJ46_RS01115	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CEJ46_RS01120	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
CEJ46_RS01125	COG2816	NAD+ diphosphatase activity
CEJ46_RS01130	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CEJ46_RS01145	COG4942	peptidase
CEJ46_RS01150	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CEJ46_RS01165	COG0490	domain, Protein
CEJ46_RS01165	COG0471	metal ion transport
CEJ46_RS01175	COG1162	GTPase activity
CEJ46_RS01180	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CEJ46_RS01230	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CEJ46_RS01235	COG0802	atpase or kinase
CEJ46_RS01240	COG0860	N-Acetylmuramoyl-L-alanine amidase
CEJ46_RS01245	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CEJ46_RS01250	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CEJ46_RS01260	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CEJ46_RS01265	COG0330	HflC and HflK could
CEJ46_RS01270	COG0330	HflC and HflK could
CEJ46_RS01275	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
CEJ46_RS01290	COG0545	Peptidyl-prolyl cis-trans isomerase
CEJ46_RS01295	COG2964	Protein conserved in bacteria
CEJ46_RS01300	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
CEJ46_RS01305	COG2923	Belongs to the DsrF TusC family
CEJ46_RS01320	COG0049	tRNA binding
CEJ46_RS01325	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CEJ46_RS01330	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CEJ46_RS01335	COG0360	Binds together with S18 to 16S ribosomal RNA
CEJ46_RS01340	COG2965	DNA replication, synthesis of RNA primer
CEJ46_RS01350	COG0359	binds to the 23S rRNA
CEJ46_RS01365	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CEJ46_RS01370	COG0166	Belongs to the GPI family
CEJ46_RS01380	COG0735	belongs to the Fur family
CEJ46_RS01385	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CEJ46_RS01405	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CEJ46_RS01415	COG0175	sulfate reduction
CEJ46_RS01500	COG1410	methionine synthase
CEJ46_RS01500	COG0646	methionine synthase
CEJ46_RS01505	COG0527	aspartate kinase activity
CEJ46_RS01510	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CEJ46_RS01525	COG2239	Acts as a magnesium transporter
CEJ46_RS01535	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CEJ46_RS01550	COG0629	single-stranded DNA binding
CEJ46_RS01555	COG2200	EAL domain
CEJ46_RS01555	COG2199	diguanylate cyclase activity
CEJ46_RS01580	COG3267	Type II secretory pathway component ExeA
CEJ46_RS01580	COG3409	Peptidoglycan-binding domain 1 protein
CEJ46_RS01590	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CEJ46_RS01595	COG1459	type II secretion system
CEJ46_RS01605	COG2165	general secretion pathway protein
CEJ46_RS01640	COG1077	Cell shape determining protein MreB Mrl
CEJ46_RS01645	COG1792	Involved in formation and maintenance of cell shape
CEJ46_RS01650	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
CEJ46_RS01655	COG0424	maF-like protein
CEJ46_RS01665	COG3164	Protein of unknown function
CEJ46_RS01670	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CEJ46_RS01675	COG0312	modulator of DNA gyrase
CEJ46_RS01680	COG2235	arginine
CEJ46_RS01710	COG5433	transposase activity
CEJ46_RS01715	COG3335	DDE superfamily endonuclease
CEJ46_RS01720	COG5433	transposase activity
CEJ46_RS01750	COG3039	Transposase
CEJ46_RS01755	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CEJ46_RS01770	COG0589	response to stress
CEJ46_RS01780	COG2358	TRAP transporter, solute receptor (TAXI family
CEJ46_RS01790	COG1438	arginine binding
CEJ46_RS01800	COG0531	amino acid
CEJ46_RS01805	COG0142	geranyltranstransferase activity
CEJ46_RS01815	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CEJ46_RS01820	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CEJ46_RS01825	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CEJ46_RS01830	COG2966	Psort location CytoplasmicMembrane, score
CEJ46_RS01835	COG3610	response to peptide
CEJ46_RS01850	COG2967	ApaG domain
CEJ46_RS01855	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CEJ46_RS01860	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CEJ46_RS01865	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CEJ46_RS01870	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CEJ46_RS01875	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CEJ46_RS01925	COG0741	lytic transglycosylase activity
CEJ46_RS01930	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
CEJ46_RS01980	COG2313	pseudouridylate synthase activity
CEJ46_RS01990	COG1846	Transcriptional regulator
CEJ46_RS01995	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CEJ46_RS02000	COG0697	spore germination
CEJ46_RS02010	COG1942	4-Oxalocrotonate Tautomerase
CEJ46_RS02015	COG0546	phosphoglycolate phosphatase activity
CEJ46_RS02025	COG1194	a g-specific adenine glycosylase
CEJ46_RS02035	COG2066	Belongs to the glutaminase family
CEJ46_RS02040	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CEJ46_RS02045	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CEJ46_RS02055	COG1872	DUF167
CEJ46_RS02060	COG0762	integral membrane protein
CEJ46_RS02065	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CEJ46_RS02070	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CEJ46_RS02085	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CEJ46_RS02090	COG1678	Uncharacterized ACR, COG1678
CEJ46_RS02100	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CEJ46_RS02105	COG2356	endonuclease I
CEJ46_RS02110	COG3091	SprT-like family
CEJ46_RS02115	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CEJ46_RS02120	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CEJ46_RS02125	COG0583	DNA-binding transcription factor activity
CEJ46_RS02130	COG4771	TonB-dependent receptor
CEJ46_RS02135	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CEJ46_RS02140	COG0126	phosphoglycerate kinase activity
CEJ46_RS02150	COG0191	fructose-bisphosphate aldolase activity
CEJ46_RS02155	COG0668	transmembrane transport
CEJ46_RS02185	COG1349	DNA-binding transcription factor activity
CEJ46_RS02195	COG2131	deaminase
CEJ46_RS02270	COG4191	Histidine kinase
CEJ46_RS02270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CEJ46_RS02295	COG3501	Rhs element vgr protein
CEJ46_RS02300	COG4104	PAAR repeat-containing protein
CEJ46_RS02360	COG0328	RNA-DNA hybrid ribonuclease activity
CEJ46_RS02380	COG1280	lysine exporter protein (LysE YggA)
CEJ46_RS02445	COG2003	Belongs to the UPF0758 family
CEJ46_RS02460	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CEJ46_RS02470	COG2189	Belongs to the N(4) N(6)-methyltransferase family
CEJ46_RS02485	COG0582	viral genome integration into host DNA
CEJ46_RS02500	COG0358	DNA primase activity
CEJ46_RS02505	COG1610	YqeY-like protein
CEJ46_RS02510	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CEJ46_RS02515	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CEJ46_RS02525	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CEJ46_RS02530	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CEJ46_RS02535	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CEJ46_RS02540	COG1968	undecaprenyl-diphosphatase activity
CEJ46_RS02545	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CEJ46_RS02550	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CEJ46_RS02555	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CEJ46_RS02560	COG0585	pseudouridine synthase activity
CEJ46_RS02565	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CEJ46_RS02570	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CEJ46_RS02575	COG4942	peptidase
CEJ46_RS02575	COG1388	LysM domain
CEJ46_RS02580	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CEJ46_RS02585	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CEJ46_RS02605	COG4208	sulfate ABC transporter
CEJ46_RS02610	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CEJ46_RS02615	COG1546	Belongs to the CinA family
CEJ46_RS02620	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CEJ46_RS02625	COG2137	regulation of response to DNA damage stimulus
CEJ46_RS02630	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CEJ46_RS02635	COG0527	aspartate kinase activity
CEJ46_RS02640	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CEJ46_RS02685	COG3630	sodium ion export across plasma membrane
CEJ46_RS02690	COG0511	ligase activity, forming carbon-carbon bonds
CEJ46_RS02690	COG5016	pyruvate
CEJ46_RS02695	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
CEJ46_RS02705	COG1238	metal cluster binding
CEJ46_RS02710	COG0612	Peptidase, M16
CEJ46_RS02720	COG1854	S-ribosylhomocysteine lyase activity
CEJ46_RS02725	COG4536	flavin adenine dinucleotide binding
CEJ46_RS02730	COG4137	Cytochrome C assembly protein
CEJ46_RS02735	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CEJ46_RS02740	COG0228	four-way junction DNA binding
CEJ46_RS02745	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CEJ46_RS02750	COG0336	Belongs to the RNA methyltransferase TrmD family
CEJ46_RS02755	COG0335	large ribosomal subunit rRNA binding
CEJ46_RS02765	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
CEJ46_RS02770	COG0237	dephospho-CoA kinase activity
CEJ46_RS02780	COG1459	type II secretion system
CEJ46_RS02785	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CEJ46_RS02795	COG0157	Belongs to the NadC ModD family
CEJ46_RS02805	COG0716	FMN binding
CEJ46_RS02810	COG4974	Belongs to the 'phage' integrase family
CEJ46_RS02815	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CEJ46_RS02820	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CEJ46_RS02825	COG2186	Transcriptional regulator
CEJ46_RS02830	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CEJ46_RS02835	COG0508	dehydrogenase complex catalyzes the overall conversion of
CEJ46_RS02840	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CEJ46_RS02855	COG0288	reversible hydration of carbon dioxide
CEJ46_RS02860	COG0659	secondary active sulfate transmembrane transporter activity
CEJ46_RS02865	COG1131	(ABC) transporter
CEJ46_RS02870	COG0842	Transport permease protein
CEJ46_RS02885	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CEJ46_RS02895	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CEJ46_RS02905	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CEJ46_RS02910	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CEJ46_RS02915	COG1489	DNA binding
CEJ46_RS02920	COG1643	Atp-dependent helicase
CEJ46_RS02925	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CEJ46_RS02930	COG1752	Esterase of the alpha-beta hydrolase superfamily
CEJ46_RS02935	COG1049	propionate catabolic process, 2-methylcitrate cycle
CEJ46_RS02940	COG1929	Belongs to the glycerate kinase type-1 family
CEJ46_RS02945	COG2610	gluconate transmembrane transporter activity
CEJ46_RS02950	COG3835	regulator
CEJ46_RS02955	COG3112	Uncharacterised protein family (UPF0231)
CEJ46_RS02965	COG0004	ammonium transporteR
CEJ46_RS02970	COG1840	ABC-type Fe3 transport system, periplasmic component
CEJ46_RS02980	COG3842	ATPase activity
CEJ46_RS02985	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CEJ46_RS03000	COG2971	BadF BadG BcrA BcrD
CEJ46_RS03010	COG4608	Belongs to the ABC transporter superfamily
CEJ46_RS03015	COG0444	Belongs to the ABC transporter superfamily
CEJ46_RS03020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CEJ46_RS03035	COG0784	Response regulator, receiver
CEJ46_RS03035	COG2205	protein histidine kinase activity
CEJ46_RS03045	COG0628	permease
CEJ46_RS03050	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CEJ46_RS03055	COG0316	Belongs to the HesB IscA family
CEJ46_RS03070	COG0739	heme binding
CEJ46_RS03075	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CEJ46_RS03085	COG2239	Acts as a magnesium transporter
CEJ46_RS03090	COG2027	D-alanyl-D-alanine carboxypeptidase
CEJ46_RS03100	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CEJ46_RS03105	COG1534	Rna-binding protein
CEJ46_RS03110	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CEJ46_RS03115	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CEJ46_RS03120	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CEJ46_RS03125	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CEJ46_RS03130	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CEJ46_RS03145	COG0779	Required for maturation of 30S ribosomal subunits
CEJ46_RS03150	COG0195	Participates in both transcription termination and antitermination
CEJ46_RS03165	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CEJ46_RS03170	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CEJ46_RS03185	COG1846	Transcriptional regulator
CEJ46_RS03195	COG0826	peptidase U32
CEJ46_RS03200	COG0826	peptidase U32
CEJ46_RS03210	COG3154	lipid carrier protein
CEJ46_RS03215	COG3153	acetyltransferase
CEJ46_RS03240	COG0513	Belongs to the DEAD box helicase family
CEJ46_RS03245	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CEJ46_RS03260	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CEJ46_RS03265	COG2204	response regulator
CEJ46_RS03275	COG0667	Aldo Keto reductase
CEJ46_RS03285	COG0494	nUDIX hydrolase
CEJ46_RS03290	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
CEJ46_RS03295	COG0730	response to heat
CEJ46_RS03305	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CEJ46_RS03310	COG1283	sodium-dependent phosphate transmembrane transporter activity
CEJ46_RS03315	COG0583	DNA-binding transcription factor activity
CEJ46_RS03320	COG0640	Transcriptional regulator
CEJ46_RS03325	COG0268	Binds directly to 16S ribosomal RNA
CEJ46_RS03330	COG0728	peptidoglycan biosynthetic process
CEJ46_RS03335	COG0196	riboflavin kinase activity
CEJ46_RS03350	COG1047	Peptidyl-prolyl cis-trans
CEJ46_RS03355	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CEJ46_RS03360	COG1966	Carbon starvation protein
CEJ46_RS03370	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CEJ46_RS03375	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CEJ46_RS03385	COG3279	Response regulator of the LytR AlgR family
CEJ46_RS03390	COG3275	phosphorelay sensor kinase activity
CEJ46_RS03395	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CEJ46_RS03400	COG1605	Chorismate mutase
CEJ46_RS03400	COG0287	Prephenate dehydrogenase
CEJ46_RS03410	COG0488	(ABC) transporter
CEJ46_RS03420	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
CEJ46_RS03425	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
CEJ46_RS03430	COG5001	Diguanylate cyclase
CEJ46_RS03435	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CEJ46_RS03440	COG1605	Chorismate mutase
CEJ46_RS03440	COG0077	Prephenate dehydratase
CEJ46_RS03445	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CEJ46_RS03450	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CEJ46_RS03455	COG0564	pseudouridine synthase activity
CEJ46_RS03460	COG1496	oxidoreductase activity
CEJ46_RS03465	COG0542	response to heat
CEJ46_RS03510	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CEJ46_RS03515	COG0826	peptidase U32
CEJ46_RS03525	COG0745	RESPONSE REGULATOR receiver
CEJ46_RS03530	COG5002	protein histidine kinase activity
CEJ46_RS03540	COG0248	Ppx GppA phosphatase
CEJ46_RS03545	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CEJ46_RS03555	COG0581	inorganic phosphate transmembrane transporter activity
CEJ46_RS03560	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CEJ46_RS03565	COG0704	Plays a role in the regulation of phosphate uptake
CEJ46_RS03575	COG0450	alkyl hydroperoxide reductase
CEJ46_RS03580	COG0583	DNA-binding transcription factor activity
CEJ46_RS03585	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CEJ46_RS03595	COG0517	IMP dehydrogenase activity
CEJ46_RS03605	COG0343	queuine tRNA-ribosyltransferase activity
CEJ46_RS03610	COG1862	Preprotein translocase
CEJ46_RS03615	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CEJ46_RS03620	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CEJ46_RS03625	COG0483	inositol monophosphate 1-phosphatase activity
CEJ46_RS03630	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
CEJ46_RS03635	COG1959	2 iron, 2 sulfur cluster binding
CEJ46_RS03645	COG0822	iron-sulfur transferase activity
CEJ46_RS03650	COG0316	Belongs to the HesB IscA family
CEJ46_RS03660	COG0443	Heat shock 70 kDa protein
CEJ46_RS03665	COG0633	Ferredoxin
CEJ46_RS03670	COG2975	iron-sulfur cluster assembly
CEJ46_RS03675	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CEJ46_RS03690	COG1426	Protein conserved in bacteria
CEJ46_RS03695	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CEJ46_RS03700	COG0124	histidyl-tRNA synthetase
CEJ46_RS03705	COG2976	Protein conserved in bacteria
CEJ46_RS03710	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CEJ46_RS03715	COG1160	GTP binding
CEJ46_RS03730	COG0516	GMP reductase activity
CEJ46_RS03730	COG0517	IMP dehydrogenase activity
CEJ46_RS03735	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CEJ46_RS03735	COG0519	Catalyzes the synthesis of GMP from XMP
CEJ46_RS03765	COG0351	phosphomethylpyrimidine kinase
CEJ46_RS03775	COG1584	GPR1 FUN34 yaaH family protein
CEJ46_RS03780	COG1115	amino acid carrier protein
CEJ46_RS03810	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CEJ46_RS03810	COG3711	transcriptional antiterminator
CEJ46_RS03825	COG3964	amidohydrolase
CEJ46_RS03870	COG3335	DDE superfamily endonuclease
CEJ46_RS03880	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CEJ46_RS03970	COG0582	viral genome integration into host DNA
CEJ46_RS04005	COG2003	Belongs to the UPF0758 family
CEJ46_RS04030	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CEJ46_RS04035	COG3716	PTS system mannose fructose sorbose family IID component
CEJ46_RS04040	COG3715	PTS system
CEJ46_RS04045	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CEJ46_RS04050	COG2222	sugar isomerase
CEJ46_RS04060	COG1349	DNA-binding transcription factor activity
CEJ46_RS04065	COG1349	DNA-binding transcription factor activity
CEJ46_RS04080	COG2003	Belongs to the UPF0758 family
CEJ46_RS04110	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CEJ46_RS04135	COG0582	viral genome integration into host DNA
CEJ46_RS04150	COG2867	negative regulation of translational initiation
CEJ46_RS04155	COG2914	Belongs to the UPF0125 (RnfH) family
CEJ46_RS04160	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CEJ46_RS04165	COG0497	DNA recombination
CEJ46_RS04170	COG0251	oxidation-reduction process
CEJ46_RS04175	COG0814	amino acid
CEJ46_RS04180	COG3033	Beta-eliminating lyase
CEJ46_RS04185	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CEJ46_RS04190	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CEJ46_RS04195	COG0443	Heat shock 70 kDa protein
CEJ46_RS04200	COG0484	heat shock protein binding
CEJ46_RS04230	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CEJ46_RS04245	COG0583	DNA-binding transcription factor activity
CEJ46_RS04250	COG0590	tRNA wobble adenosine to inosine editing
CEJ46_RS04255	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CEJ46_RS04265	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CEJ46_RS04265	COG0047	phosphoribosylformylglycinamidine synthase activity
CEJ46_RS04285	COG2979	Protein of unknown function (DUF533)
CEJ46_RS04290	COG0442	prolyl-tRNA aminoacylation
CEJ46_RS04295	COG1720	tRNA m6t6A37 methyltransferase activity
CEJ46_RS04300	COG0254	rRNA binding
CEJ46_RS04305	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CEJ46_RS04335	COG3098	single-species biofilm formation
CEJ46_RS04340	COG0564	pseudouridine synthase activity
CEJ46_RS04345	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CEJ46_RS04350	COG0142	geranyltranstransferase activity
CEJ46_RS04355	COG1722	exodeoxyribonuclease VII activity
CEJ46_RS04360	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CEJ46_RS04370	COG0301	tRNA thio-modification
CEJ46_RS04370	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CEJ46_RS04375	COG0583	DNA-binding transcription factor activity
CEJ46_RS04380	COG2363	Small membrane protein
CEJ46_RS04385	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
CEJ46_RS04390	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CEJ46_RS04395	COG1611	Belongs to the LOG family
CEJ46_RS04420	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
CEJ46_RS04425	COG1464	Belongs to the NlpA lipoprotein family
CEJ46_RS04430	COG2011	ABC-type metal ion transport system permease component
CEJ46_RS04435	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CEJ46_RS04440	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CEJ46_RS04450	COG1609	Transcriptional regulator
CEJ46_RS04455	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CEJ46_RS04455	COG1263	PTS System
CEJ46_RS04460	COG0366	Alpha amylase catalytic
CEJ46_RS04465	COG0745	RESPONSE REGULATOR receiver
CEJ46_RS04470	COG2205	protein histidine kinase activity
CEJ46_RS04505	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CEJ46_RS04510	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CEJ46_RS04525	COG3335	DDE superfamily endonuclease
CEJ46_RS04530	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CEJ46_RS04535	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CEJ46_RS04540	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CEJ46_RS04580	COG1045	serine acetyltransferase
CEJ46_RS04590	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
CEJ46_RS04620	COG0489	protein tyrosine kinase activity
CEJ46_RS04625	COG1596	polysaccharide export
CEJ46_RS04655	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CEJ46_RS04660	COG0321	lipoyl(octanoyl) transferase activity
CEJ46_RS04665	COG2921	Belongs to the UPF0250 family
CEJ46_RS04670	COG1686	Belongs to the peptidase S11 family
CEJ46_RS04675	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CEJ46_RS04680	COG0772	Belongs to the SEDS family
CEJ46_RS04685	COG0768	penicillin binding
CEJ46_RS04690	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CEJ46_RS04695	COG0799	negative regulation of ribosome biogenesis
CEJ46_RS04700	COG1466	dna polymerase III delta subunit
CEJ46_RS04705	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
CEJ46_RS04710	COG0495	leucyl-tRNA aminoacylation
CEJ46_RS04715	COG2888	peptidyl-tyrosine sulfation
CEJ46_RS04720	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CEJ46_RS04725	COG4535	Mg2 and Co2 transporter CorC
CEJ46_RS04730	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CEJ46_RS04735	COG1702	phosphate starvation-inducible protein PhoH
CEJ46_RS04740	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CEJ46_RS04745	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CEJ46_RS04750	COG2190	(PTS) system
CEJ46_RS04755	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CEJ46_RS04760	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CEJ46_RS04765	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CEJ46_RS04770	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
CEJ46_RS04775	COG3115	cell septum assembly
CEJ46_RS04780	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CEJ46_RS04795	COG0789	Transcriptional regulator
CEJ46_RS04805	COG0330	HflC and HflK could
CEJ46_RS04815	COG3118	belongs to the thioredoxin family
CEJ46_RS04820	COG1090	epimerase
CEJ46_RS04825	COG0622	Phosphoesterase
CEJ46_RS04840	COG3710	Transcriptional regulator
CEJ46_RS04845	COG0326	Molecular chaperone. Has ATPase activity
CEJ46_RS04855	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CEJ46_RS04860	COG3104	oligopeptide transport
CEJ46_RS04870	COG0367	asparagine synthase
CEJ46_RS04875	COG4651	solute:proton antiporter activity
CEJ46_RS04875	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CEJ46_RS04880	COG1940	carbohydrate kinase activity
CEJ46_RS04880	COG1846	Transcriptional regulator
CEJ46_RS04885	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CEJ46_RS04890	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CEJ46_RS04890	COG1263	PTS System
CEJ46_RS04890	COG2190	(PTS) system
CEJ46_RS04895	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CEJ46_RS04905	COG0101	tRNA pseudouridine synthase activity
CEJ46_RS04910	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CEJ46_RS04915	COG0285	dihydrofolate synthase activity
CEJ46_RS04920	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
CEJ46_RS04925	COG1286	toxin biosynthetic process
CEJ46_RS04930	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CEJ46_RS04935	COG2056	Na+-H+ antiporter family
CEJ46_RS04940	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CEJ46_RS04950	COG0346	lactoylglutathione lyase activity
CEJ46_RS04965	COG0784	Response regulator, receiver
CEJ46_RS04965	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CEJ46_RS04980	COG3335	DDE superfamily endonuclease
CEJ46_RS04990	COG5433	transposase activity
CEJ46_RS05015	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CEJ46_RS05020	COG4660	Part of a membrane complex involved in electron transport
CEJ46_RS05025	COG4659	FMN binding
CEJ46_RS05030	COG4658	electron transport chain
CEJ46_RS05035	COG4656	Part of a membrane complex involved in electron transport
CEJ46_RS05040	COG2878	Part of a membrane complex involved in electron transport
CEJ46_RS05045	COG4657	Part of a membrane complex involved in electron transport
CEJ46_RS05055	COG1629	transport
CEJ46_RS05055	COG4774	siderophore transport
CEJ46_RS05060	COG2382	esterase
CEJ46_RS05080	COG1535	isochorismatase
CEJ46_RS05080	COG3433	isochorismatase activity
CEJ46_RS05085	COG1021	2,3-dihydroxybenzoate-AMP ligase
CEJ46_RS05090	COG1169	isochorismate synthase
CEJ46_RS05095	COG1028	Short-chain dehydrogenase reductase Sdr
CEJ46_RS05100	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CEJ46_RS05110	COG1902	pentaerythritol trinitrate reductase activity
CEJ46_RS05120	COG2814	Major facilitator Superfamily
CEJ46_RS05125	COG1028	Short-chain dehydrogenase reductase Sdr
CEJ46_RS05140	COG0556	nucleotide-excision repair
CEJ46_RS05145	COG2204	response regulator
CEJ46_RS05150	COG2198	Histidine kinase
CEJ46_RS05155	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CEJ46_RS05160	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CEJ46_RS05165	COG0521	Mo-molybdopterin cofactor biosynthetic process
CEJ46_RS05175	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CEJ46_RS05180	COG0314	molybdopterin synthase activity
CEJ46_RS05185	COG2199	diguanylate cyclase activity
CEJ46_RS05190	COG0617	tRNA 3'-terminal CCA addition
CEJ46_RS05190	COG0517	IMP dehydrogenase activity
CEJ46_RS05190	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CEJ46_RS05200	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
CEJ46_RS05210	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CEJ46_RS05210	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CEJ46_RS05215	COG0489	protein tyrosine kinase activity
CEJ46_RS05220	COG0572	uridine kinase
CEJ46_RS05225	COG2982	Protein involved in outer membrane biogenesis
CEJ46_RS05230	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
CEJ46_RS05235	COG2067	long-chain fatty acid transport protein
CEJ46_RS05240	COG2067	long-chain fatty acid transport protein
CEJ46_RS05250	COG1595	DNA-templated transcription, initiation
CEJ46_RS05260	COG0183	Belongs to the thiolase family
CEJ46_RS05265	COG1250	3-hydroxyacyl-CoA dehydrogenase
CEJ46_RS05265	COG1024	Enoyl-CoA hydratase
CEJ46_RS05270	COG0778	Nitroreductase
CEJ46_RS05275	COG0583	DNA-binding transcription factor activity
CEJ46_RS05280	COG0745	RESPONSE REGULATOR receiver
CEJ46_RS05290	COG2832	Protein of unknown function (DUF454)
CEJ46_RS05295	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CEJ46_RS05310	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CEJ46_RS05320	COG2983	Belongs to the UPF0260 family
CEJ46_RS05335	COG2226	methyltransferase
CEJ46_RS05350	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CEJ46_RS05360	COG3139	Protein of unknown function (DUF1315)
CEJ46_RS05365	COG0252	asparaginase activity
CEJ46_RS05370	COG0616	signal peptide processing
CEJ46_RS05375	COG1902	pentaerythritol trinitrate reductase activity
CEJ46_RS05375	COG0446	pyridine nucleotide-disulphide oxidoreductase
CEJ46_RS05380	COG0788	formyltetrahydrofolate deformylase activity
CEJ46_RS05390	COG1199	ATP-dependent helicase activity
CEJ46_RS05395	COG1214	PFAM Peptidase M22, glycoprotease
CEJ46_RS05410	COG0596	Alpha beta hydrolase
CEJ46_RS05415	COG0318	PFAM AMP-dependent synthetase and ligase
CEJ46_RS05420	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CEJ46_RS05425	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CEJ46_RS05430	COG2894	cell division
CEJ46_RS05440	COG3100	YcgL domain-containing protein
CEJ46_RS05445	COG2951	lytic endotransglycosylase activity
CEJ46_RS05450	COG0583	DNA-binding transcription factor activity
CEJ46_RS05455	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CEJ46_RS05480	COG4628	conserved protein (DUF2132)
CEJ46_RS05495	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CEJ46_RS05505	COG0513	Belongs to the DEAD box helicase family
CEJ46_RS05515	COG1760	l-serine dehydratase
CEJ46_RS05535	COG2205	protein histidine kinase activity
CEJ46_RS05540	COG1653	transport
CEJ46_RS05550	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CEJ46_RS05555	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CEJ46_RS05560	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CEJ46_RS05580	COG0544	peptidyl-prolyl cis-trans isomerase activity
CEJ46_RS05590	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CEJ46_RS05595	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CEJ46_RS05600	COG0776	regulation of translation
CEJ46_RS05605	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CEJ46_RS05610	COG1555	photosystem II stabilization
CEJ46_RS05615	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CEJ46_RS05620	COG0539	negative regulation of cytoplasmic translation
CEJ46_RS05625	COG0776	regulation of translation
CEJ46_RS05630	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
CEJ46_RS05635	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CEJ46_RS05650	COG0583	DNA-binding transcription factor activity
CEJ46_RS05660	COG0686	Belongs to the AlaDH PNT family
CEJ46_RS05665	COG1522	sequence-specific DNA binding
CEJ46_RS05670	COG1674	ftsk spoiiie
CEJ46_RS05680	COG0501	Belongs to the peptidase M48B family
CEJ46_RS05690	COG0300	oxidoreductase activity
CEJ46_RS05705	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CEJ46_RS05715	COG2268	Band 7 protein
CEJ46_RS05725	COG1032	radical SAM domain protein
CEJ46_RS05730	COG5640	endopeptidase activity
CEJ46_RS05750	COG0583	DNA-binding transcription factor activity
CEJ46_RS05755	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CEJ46_RS05765	COG2350	Protein conserved in bacteria
CEJ46_RS05795	COG0159	tryptophan synthase activity
CEJ46_RS05800	COG0133	tryptophan synthase activity
CEJ46_RS05805	COG0135	phosphoribosylanthranilate isomerase activity
CEJ46_RS05805	COG0134	indole-3-glycerol-phosphate synthase activity
CEJ46_RS05810	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CEJ46_RS05815	COG0512	Glutamine amidotransferase of anthranilate synthase
CEJ46_RS05820	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CEJ46_RS05830	COG0613	PHP domain protein
CEJ46_RS05835	COG0009	L-threonylcarbamoyladenylate synthase
CEJ46_RS05840	COG1187	pseudouridine synthase activity
CEJ46_RS05850	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CEJ46_RS05855	COG4988	ABC transporter
CEJ46_RS05860	COG0492	ferredoxin-NADP+ reductase activity
CEJ46_RS05880	COG2949	membrane
CEJ46_RS05890	COG0281	malic enzyme
CEJ46_RS05900	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CEJ46_RS05905	COG3273	potassium ion transport
CEJ46_RS05905	COG2985	domain, Protein
CEJ46_RS05910	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CEJ46_RS05920	COG1737	Transcriptional regulator
CEJ46_RS05925	COG0076	glutamate decarboxylase activity
CEJ46_RS05935	COG2431	L-lysine efflux transmembrane transporter activity
CEJ46_RS05945	COG3070	regulator of competence-specific genes
CEJ46_RS05960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CEJ46_RS05960	COG4191	Histidine kinase
CEJ46_RS05970	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CEJ46_RS05975	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CEJ46_RS05980	COG2915	High frequency lysogenization protein hflD homolog
CEJ46_RS05985	COG0482	sulfurtransferase activity
CEJ46_RS05995	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CEJ46_RS06000	COG2916	Histone family protein nucleoid-structuring protein H-NS
CEJ46_RS06005	COG1757	Na H antiporter
CEJ46_RS06010	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CEJ46_RS06015	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CEJ46_RS06020	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CEJ46_RS06025	COG0131	Imidazoleglycerol-phosphate dehydratase
CEJ46_RS06025	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CEJ46_RS06030	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CEJ46_RS06035	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CEJ46_RS06040	COG0107	imidazoleglycerol-phosphate synthase activity
CEJ46_RS06045	COG0140	phosphoribosyl-ATP diphosphatase activity
CEJ46_RS06045	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CEJ46_RS06050	COG1187	pseudouridine synthase activity
CEJ46_RS06060	COG1278	Cold shock
CEJ46_RS06065	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CEJ46_RS06070	COG0542	response to heat
CEJ46_RS06075	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CEJ46_RS06080	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
CEJ46_RS06085	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CEJ46_RS06100	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CEJ46_RS06105	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CEJ46_RS06110	COG0297	glycogen (starch) synthase activity
CEJ46_RS06130	COG3070	regulator of competence-specific genes
CEJ46_RS06135	COG1609	Transcriptional regulator
CEJ46_RS06145	COG0745	RESPONSE REGULATOR receiver
CEJ46_RS06150	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CEJ46_RS06155	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CEJ46_RS06165	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
CEJ46_RS06170	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
CEJ46_RS06185	COG4067	protein conserved in archaea
CEJ46_RS06185	COG0189	ligase activity
CEJ46_RS06190	COG0500	methyltransferase
CEJ46_RS06200	COG1801	Protein of unknown function DUF72
CEJ46_RS06205	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CEJ46_RS06210	COG1435	thymidine kinase activity
CEJ46_RS06220	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CEJ46_RS06245	COG2116	formate transmembrane transporter activity
CEJ46_RS06250	COG4459	periplasmic nitrate reductase
CEJ46_RS06255	COG3005	denitrification pathway
CEJ46_RS06260	COG0243	molybdopterin cofactor binding
CEJ46_RS06270	COG1227	inorganic diphosphatase activity
CEJ46_RS06290	COG4172	Belongs to the ABC transporter superfamily
CEJ46_RS06300	COG4171	peptide transport system, permease
CEJ46_RS06315	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CEJ46_RS06320	COG1842	Phage shock protein A
CEJ46_RS06335	COG0519	Catalyzes the synthesis of GMP from XMP
CEJ46_RS06340	COG0626	cystathionine gamma-synthase activity
CEJ46_RS06350	COG0733	neurotransmitter:sodium symporter activity
CEJ46_RS06355	COG0564	pseudouridine synthase activity
CEJ46_RS06365	COG2200	EAL domain
CEJ46_RS06370	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CEJ46_RS06375	COG4136	ATPase activity
CEJ46_RS06380	COG4135	transport system, permease component
CEJ46_RS06385	COG4134	Bacterial extracellular solute-binding protein
CEJ46_RS06395	COG3313	Fe-S protein
CEJ46_RS06405	COG0737	Belongs to the 5'-nucleotidase family
CEJ46_RS06415	COG0513	Belongs to the DEAD box helicase family
CEJ46_RS06430	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CEJ46_RS06435	COG2205	protein histidine kinase activity
CEJ46_RS06450	COG1061	Type III restriction enzyme res subunit
CEJ46_RS06455	COG1187	pseudouridine synthase activity
CEJ46_RS06460	COG2814	Major facilitator Superfamily
CEJ46_RS06470	COG0702	epimerase
CEJ46_RS06475	COG0534	Mate efflux family protein
CEJ46_RS06480	COG4181	ATPase activity
CEJ46_RS06495	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CEJ46_RS06500	COG5433	transposase activity
CEJ46_RS06555	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CEJ46_RS06560	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CEJ46_RS06565	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CEJ46_RS06575	COG0840	transmembrane signaling receptor activity
CEJ46_RS06590	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CEJ46_RS06590	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CEJ46_RS06590	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CEJ46_RS06595	COG2207	Transcriptional regulator
CEJ46_RS06605	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CEJ46_RS06615	COG1342	Belongs to the UPF0251 family
CEJ46_RS06635	COG1129	ABC transporter
CEJ46_RS06650	COG1902	pentaerythritol trinitrate reductase activity
CEJ46_RS06655	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CEJ46_RS06660	COG5002	protein histidine kinase activity
CEJ46_RS06665	COG0745	RESPONSE REGULATOR receiver
CEJ46_RS06695	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CEJ46_RS06700	COG0372	Belongs to the citrate synthase family
CEJ46_RS06705	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CEJ46_RS06710	COG2828	Protein conserved in bacteria
CEJ46_RS06730	COG0561	phosphatase activity
CEJ46_RS06735	COG0602	queuosine metabolic process
CEJ46_RS06765	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CEJ46_RS06770	COG1254	Belongs to the acylphosphatase family
CEJ46_RS06775	COG2920	part of a sulfur-relay system
CEJ46_RS06780	COG0670	Belongs to the BI1 family
CEJ46_RS06785	COG1126	abc transporter atp-binding protein
CEJ46_RS06790	COG0765	amino acid transport
CEJ46_RS06795	COG4597	amino acid ABC transporter
CEJ46_RS06800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CEJ46_RS06805	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CEJ46_RS06805	COG1648	precorrin-2 dehydrogenase activity
CEJ46_RS06815	COG1666	GTP binding
CEJ46_RS06820	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CEJ46_RS06825	COG0574	Belongs to the PEP-utilizing enzyme family
CEJ46_RS06825	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CEJ46_RS06840	COG2996	Protein conserved in bacteria
CEJ46_RS06860	COG3008	intermembrane lipid transfer
CEJ46_RS06865	COG2995	paraquat-inducible protein a
CEJ46_RS06870	COG1132	(ABC) transporter
CEJ46_RS06875	COG1956	GAF domain-containing protein
CEJ46_RS06880	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
CEJ46_RS06895	COG0308	aminopeptidase N
CEJ46_RS06905	COG2902	Dehydrogenase
CEJ46_RS06910	COG0167	dihydroorotate dehydrogenase activity
CEJ46_RS06930	COG0488	(ABC) transporter
CEJ46_RS06945	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CEJ46_RS06950	COG1067	ATP-dependent peptidase activity
CEJ46_RS06955	COG3120	sequence-specific DNA binding
CEJ46_RS06975	COG3278	Belongs to the heme-copper respiratory oxidase family
CEJ46_RS06990	COG2010	Cytochrome c
CEJ46_RS07000	COG2217	Heavy metal translocating P-type atpase
CEJ46_RS07015	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CEJ46_RS07020	COG0589	response to stress
CEJ46_RS07045	COG3842	ATPase activity
CEJ46_RS07050	COG1176	ABC-type spermidine putrescine transport system, permease component I
CEJ46_RS07055	COG1177	transmembrane transport
CEJ46_RS07060	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CEJ46_RS07070	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CEJ46_RS07075	COG0004	ammonium transporteR
CEJ46_RS07080	COG0488	(ABC) transporter
CEJ46_RS07085	COG2197	response regulator
CEJ46_RS07095	COG2271	Major facilitator Superfamily
CEJ46_RS07100	COG1840	ABC-type Fe3 transport system, periplasmic component
CEJ46_RS07110	COG3842	ATPase activity
CEJ46_RS07115	COG0746	molybdenum cofactor guanylyltransferase activity
CEJ46_RS07120	COG1763	Mo-molybdopterin cofactor biosynthetic process
CEJ46_RS07130	COG1940	carbohydrate kinase activity
CEJ46_RS07135	COG3148	PFAM DTW domain containing protein
CEJ46_RS07145	COG0840	transmembrane signaling receptor activity
CEJ46_RS07150	COG0791	NLP P60 protein
CEJ46_RS07160	COG3001	Fructosamine kinase
CEJ46_RS07175	COG1793	dna ligase
CEJ46_RS07180	COG4667	esterase of the alpha-beta hydrolase superfamily
CEJ46_RS07195	COG0848	biopolymer transport protein
CEJ46_RS07200	COG0811	peptide transport
CEJ46_RS07205	COG0811	peptide transport
CEJ46_RS07235	COG0625	glutathione transferase activity
CEJ46_RS07245	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
CEJ46_RS07255	COG2195	Cleaves the N-terminal amino acid of tripeptides
CEJ46_RS07270	COG1115	amino acid carrier protein
CEJ46_RS07275	COG1280	lysine exporter protein (LysE YggA)
CEJ46_RS07280	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CEJ46_RS07285	COG0477	Major facilitator Superfamily
CEJ46_RS07290	COG0583	DNA-binding transcription factor activity
CEJ46_RS07300	COG1643	Atp-dependent helicase
CEJ46_RS07320	COG3706	GGDEF domain
CEJ46_RS07335	COG0443	Heat shock 70 kDa protein
CEJ46_RS07365	COG1609	Transcriptional regulator
CEJ46_RS07370	COG2723	6-phospho-beta-galactosidase activity
CEJ46_RS07375	COG0513	Belongs to the DEAD box helicase family
CEJ46_RS07380	COG0243	molybdopterin cofactor binding
CEJ46_RS07385	COG3005	denitrification pathway
CEJ46_RS07390	COG1278	Cold shock
CEJ46_RS07405	COG4191	Histidine kinase
CEJ46_RS07405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CEJ46_RS07410	COG0471	metal ion transport
CEJ46_RS07420	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CEJ46_RS07440	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CEJ46_RS07450	COG3768	UPF0283 membrane protein
CEJ46_RS07455	COG3106	COG3106 Predicted ATPase
CEJ46_RS07480	COG0814	amino acid
CEJ46_RS07485	COG1760	l-serine dehydratase
CEJ46_RS07495	COG2356	endonuclease I
CEJ46_RS07500	COG0720	synthase
CEJ46_RS07505	COG0840	transmembrane signaling receptor activity
CEJ46_RS07510	COG0017	Asparaginyl-tRNA synthetase
CEJ46_RS07520	COG2201	protein-glutamate methylesterase activity
CEJ46_RS07525	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CEJ46_RS07530	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CEJ46_RS07535	COG0835	chemotaxis
CEJ46_RS07545	COG0643	Histidine kinase
CEJ46_RS07545	COG2198	Histidine kinase
CEJ46_RS07555	COG0745	RESPONSE REGULATOR receiver
CEJ46_RS07560	COG0840	transmembrane signaling receptor activity
CEJ46_RS07565	COG2770	Histidine kinase
CEJ46_RS07565	COG3437	response regulator, receiver
CEJ46_RS07570	COG1448	Aminotransferase
CEJ46_RS07575	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
CEJ46_RS07585	COG0840	transmembrane signaling receptor activity
CEJ46_RS07590	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CEJ46_RS07595	COG1846	Transcriptional regulator
CEJ46_RS07610	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CEJ46_RS07615	COG3108	Peptidase M15
CEJ46_RS07620	COG2989	Protein conserved in bacteria
CEJ46_RS07650	COG1940	carbohydrate kinase activity
CEJ46_RS07660	COG0748	coenzyme F420 binding
CEJ46_RS07665	COG3721	Heme iron utilization protein
CEJ46_RS07670	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
CEJ46_RS07675	COG0811	peptide transport
CEJ46_RS07680	COG0848	biopolymer transport protein
CEJ46_RS07690	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CEJ46_RS07695	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CEJ46_RS07700	COG1054	Belongs to the UPF0176 family
CEJ46_RS07720	COG1621	beta-fructofuranosidase activity
CEJ46_RS07730	COG1263	PTS System
CEJ46_RS07730	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CEJ46_RS07735	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CEJ46_RS07740	COG2200	EAL domain
CEJ46_RS07745	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CEJ46_RS07750	COG0840	transmembrane signaling receptor activity
CEJ46_RS07755	COG1294	oxidase, subunit
CEJ46_RS07760	COG1271	oxidase subunit
CEJ46_RS07785	COG3220	belongs to the UPF0276 family
CEJ46_RS07805	COG1294	oxidase, subunit
CEJ46_RS07815	COG0251	oxidation-reduction process
CEJ46_RS07835	COG5433	transposase activity
CEJ46_RS07865	COG2801	Transposase and inactivated derivatives
CEJ46_RS07905	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CEJ46_RS07910	COG1012	belongs to the aldehyde dehydrogenase family
CEJ46_RS07960	COG0515	serine threonine protein kinase
CEJ46_RS07960	COG4991	sh3 domain protein
CEJ46_RS07960	COG3064	Membrane
CEJ46_RS07985	COG1716	ATPase activity
CEJ46_RS08005	COG1181	Belongs to the D-alanine--D-alanine ligase family
CEJ46_RS08085	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CEJ46_RS08130	COG0835	chemotaxis
CEJ46_RS08130	COG0784	Response regulator, receiver
CEJ46_RS08140	COG4565	transcriptional regulatory protein
CEJ46_RS08145	COG3290	protein histidine kinase activity
CEJ46_RS08160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CEJ46_RS08185	COG3063	Type IV pilus biogenesis stability protein PilW
CEJ46_RS08200	COG1451	nucleotide metabolic process
CEJ46_RS08210	COG0583	DNA-binding transcription factor activity
CEJ46_RS08230	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
CEJ46_RS08235	COG4139	cobalamin transport
CEJ46_RS08240	COG2988	succinylglutamate desuccinylase activity
CEJ46_RS08255	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CEJ46_RS08260	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CEJ46_RS08265	COG1073	alpha beta
CEJ46_RS08265	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
CEJ46_RS08265	COG3064	Membrane
CEJ46_RS08270	COG2994	toxin metabolic process
CEJ46_RS08300	COG0702	epimerase
CEJ46_RS08305	COG1823	symporter activity
CEJ46_RS08310	COG2925	Exonuclease
CEJ46_RS08315	COG1380	Effector of murein hydrolase LrgA
CEJ46_RS08320	COG1346	cytolysis
CEJ46_RS08330	COG5001	Diguanylate cyclase
CEJ46_RS08330	COG3300	MHYT domain
CEJ46_RS08345	COG0500	methyltransferase
CEJ46_RS08355	COG0776	regulation of translation
CEJ46_RS08360	COG0072	phenylalanine-tRNA ligase activity
CEJ46_RS08360	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CEJ46_RS08365	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CEJ46_RS08405	COG0322	excinuclease ABC activity
CEJ46_RS08410	COG2197	response regulator
CEJ46_RS08415	COG0417	DNA replication proofreading
CEJ46_RS08425	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CEJ46_RS08430	COG3099	Belongs to the UPF0263 family
CEJ46_RS08435	COG3097	Belongs to the UPF0267 family
CEJ46_RS08445	COG1228	amidohydrolase
CEJ46_RS08450	COG0010	Belongs to the arginase family
CEJ46_RS08460	COG2986	histidine ammonia-lyase
CEJ46_RS08475	COG0247	lactate metabolic process
CEJ46_RS08475	COG0277	FAD linked oxidase domain protein
CEJ46_RS08505	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CEJ46_RS08510	COG1960	acyl-CoA dehydrogenase activity
CEJ46_RS08525	COG5433	transposase activity
CEJ46_RS08545	COG3300	MHYT domain
CEJ46_RS08545	COG5001	Diguanylate cyclase
CEJ46_RS08565	COG5002	protein histidine kinase activity
CEJ46_RS08565	COG0784	Response regulator, receiver
CEJ46_RS08575	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CEJ46_RS08580	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
CEJ46_RS08585	COG2885	chlorophyll binding
CEJ46_RS08590	COG0823	Involved in the tonB-independent uptake of proteins
CEJ46_RS08605	COG0811	peptide transport
CEJ46_RS08610	COG0824	Thioesterase
CEJ46_RS08615	COG3790	cyd operon protein YbgE
CEJ46_RS08620	COG4890	Cyd operon protein YbgT
CEJ46_RS08625	COG1294	oxidase, subunit
CEJ46_RS08630	COG1271	oxidase subunit
CEJ46_RS08635	COG2255	four-way junction helicase activity
CEJ46_RS08640	COG0632	four-way junction helicase activity
CEJ46_RS08645	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CEJ46_RS08650	COG0215	cysteine-tRNA ligase activity
CEJ46_RS08655	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CEJ46_RS08660	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CEJ46_RS08665	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
CEJ46_RS08670	COG3012	SEC-C Motif Domain Protein
CEJ46_RS08685	COG1199	ATP-dependent helicase activity
CEJ46_RS08695	COG3923	Primosomal replication protein n
CEJ46_RS08705	COG0840	transmembrane signaling receptor activity
CEJ46_RS08710	COG0708	Exodeoxyribonuclease III
CEJ46_RS08715	COG4160	amino acid transport
CEJ46_RS08745	COG1882	Formate acetyltransferase
CEJ46_RS08760	COG3335	DDE superfamily endonuclease
CEJ46_RS08770	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CEJ46_RS08780	COG3013	Belongs to the UPF0304 family
CEJ46_RS08785	COG2766	serine protein kinase
CEJ46_RS08790	COG2718	Belongs to the UPF0229 family
CEJ46_RS08795	COG2719	SpoVR family
CEJ46_RS08800	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CEJ46_RS08815	COG1132	(ABC) transporter
CEJ46_RS08820	COG0658	competence protein
CEJ46_RS08820	COG2333	competence protein COMEC
CEJ46_RS08830	COG4591	ABC-type transport system involved in lipoprotein release permease component
CEJ46_RS08835	COG1136	(ABC) transporter
CEJ46_RS08840	COG4591	ABC-type transport system involved in lipoprotein release permease component
CEJ46_RS08850	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CEJ46_RS08865	COG1252	NADH dehydrogenase
CEJ46_RS08870	COG3150	esterase
CEJ46_RS08895	COG0537	adenosine 5'-monophosphoramidase activity
CEJ46_RS08910	COG2186	Transcriptional regulator
CEJ46_RS08915	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CEJ46_RS08925	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CEJ46_RS08930	COG2226	methyltransferase
CEJ46_RS08940	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CEJ46_RS08945	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CEJ46_RS08955	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CEJ46_RS08960	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CEJ46_RS08970	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CEJ46_RS08980	COG4120	Belongs to the binding-protein-dependent transport system permease family
CEJ46_RS08990	COG3092	negative regulation of chromosome organization
CEJ46_RS08995	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CEJ46_RS09000	COG0857	belongs to the CobB CobQ family
CEJ46_RS09000	COG0280	phosphate acetyltransferase
CEJ46_RS09005	COG0435	Glutathione S-transferase
CEJ46_RS09015	COG0444	Belongs to the ABC transporter superfamily
CEJ46_RS09020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CEJ46_RS09025	COG0601	transmembrane transport
CEJ46_RS09065	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CEJ46_RS09070	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CEJ46_RS09090	COG1215	transferase activity, transferring glycosyl groups
CEJ46_RS09125	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CEJ46_RS09130	COG1028	Short-chain dehydrogenase reductase Sdr
CEJ46_RS09155	COG3706	GGDEF domain
CEJ46_RS09165	COG0800	Aldolase
CEJ46_RS09170	COG2610	gluconate transmembrane transporter activity
CEJ46_RS09175	COG3265	gluconokinase activity
CEJ46_RS09180	COG0129	dihydroxy-acid dehydratase activity
CEJ46_RS09185	COG1609	Transcriptional regulator
CEJ46_RS09200	COG5002	protein histidine kinase activity
CEJ46_RS09200	COG3850	Histidine kinase
CEJ46_RS09210	COG2985	domain, Protein
CEJ46_RS09225	COG2194	sulfuric ester hydrolase activity
CEJ46_RS09230	COG0642	Histidine kinase
CEJ46_RS09235	COG0745	RESPONSE REGULATOR receiver
CEJ46_RS09245	COG4221	oxidoreductase activity
CEJ46_RS09255	COG1022	Amp-dependent synthetase and ligase
CEJ46_RS09295	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CEJ46_RS09345	COG3706	GGDEF domain
CEJ46_RS09360	COG3126	Type III secretion system lipoprotein chaperone (YscW)
CEJ46_RS09365	COG1946	Acyl-CoA thioesterase
CEJ46_RS09370	COG1522	sequence-specific DNA binding
CEJ46_RS09405	COG0318	PFAM AMP-dependent synthetase and ligase
CEJ46_RS09415	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CEJ46_RS09425	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CEJ46_RS09430	COG1169	isochorismate synthase
CEJ46_RS09440	COG0436	Aminotransferase
CEJ46_RS09445	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
CEJ46_RS09450	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CEJ46_RS09465	COG0616	signal peptide processing
CEJ46_RS09470	COG1028	Short-chain dehydrogenase reductase Sdr
CEJ46_RS09475	COG0784	Response regulator, receiver
CEJ46_RS09475	COG0835	chemotaxis
CEJ46_RS09480	COG1940	carbohydrate kinase activity
CEJ46_RS09490	COG4667	esterase of the alpha-beta hydrolase superfamily
CEJ46_RS09500	COG0733	neurotransmitter:sodium symporter activity
CEJ46_RS09510	COG1263	PTS System
CEJ46_RS09510	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CEJ46_RS09515	COG0084	hydrolase, TatD family'
CEJ46_RS09520	COG0470	DNA polymerase III
CEJ46_RS09525	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CEJ46_RS09530	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CEJ46_RS09535	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CEJ46_RS09560	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CEJ46_RS09575	COG1399	metal-binding, possibly nucleic acid-binding protein
CEJ46_RS09580	COG0424	maF-like protein
CEJ46_RS09585	COG0564	pseudouridine synthase activity
CEJ46_RS09590	COG1530	ribonuclease E activity
CEJ46_RS09600	COG1012	belongs to the aldehyde dehydrogenase family
CEJ46_RS09600	COG1454	alcohol dehydrogenase
CEJ46_RS09605	COG2095	MarC family integral membrane protein
CEJ46_RS09610	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CEJ46_RS09615	COG1757	Na H antiporter
CEJ46_RS09630	COG3082	Protein of unknown function (DUF1414)
CEJ46_RS09645	COG0243	molybdopterin cofactor binding
CEJ46_RS09650	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CEJ46_RS09670	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CEJ46_RS09675	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CEJ46_RS09695	COG2853	Lipoprotein
CEJ46_RS09710	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CEJ46_RS09715	COG1138	Cytochrome C-type biogenesis protein
CEJ46_RS09720	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CEJ46_RS09730	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CEJ46_RS09735	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CEJ46_RS09740	COG4133	protoheme IX ABC transporter activity
CEJ46_RS09750	COG0835	chemotaxis
CEJ46_RS09760	COG1192	Involved in chromosome partitioning
CEJ46_RS09765	COG2201	protein-glutamate methylesterase activity
CEJ46_RS09770	COG0643	Histidine kinase
CEJ46_RS09770	COG0784	Response regulator, receiver
CEJ46_RS09770	COG2198	Histidine kinase
CEJ46_RS09775	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
CEJ46_RS09800	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CEJ46_RS09805	COG2062	phosphohistidine phosphatase, SixA
CEJ46_RS09810	COG1025	Belongs to the peptidase M16 family
CEJ46_RS09815	COG3102	Protein conserved in bacteria
CEJ46_RS09840	COG1918	ferrous iron import across plasma membrane
CEJ46_RS09845	COG4977	sequence-specific DNA binding
CEJ46_RS09850	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
CEJ46_RS09855	COG1121	(ABC) transporter
CEJ46_RS09860	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CEJ46_RS09875	COG0508	dehydrogenase complex catalyzes the overall conversion of
CEJ46_RS09880	COG0567	Dehydrogenase, E1 component
CEJ46_RS09895	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CEJ46_RS09910	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CEJ46_RS09920	COG0033	Phosphoglucomutase
CEJ46_RS09925	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
CEJ46_RS09930	COG0596	Alpha beta hydrolase
CEJ46_RS09945	COG1346	cytolysis
CEJ46_RS09955	COG0583	DNA-binding transcription factor activity
CEJ46_RS09965	COG0735	belongs to the Fur family
CEJ46_RS09970	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CEJ46_RS09975	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CEJ46_RS09980	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CEJ46_RS09985	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CEJ46_RS09985	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CEJ46_RS09990	COG0431	NADPH-dependent FMN reductase
CEJ46_RS10000	COG3101	peptidyl-lysine hydroxylation
CEJ46_RS10005	COG2860	membrane
CEJ46_RS10010	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CEJ46_RS10015	COG2890	protein-(glutamine-N5) methyltransferase activity
CEJ46_RS10020	COG2840	Smr protein MutS2
CEJ46_RS10030	COG1684	flagellar biosynthetic protein fliR
CEJ46_RS10035	COG1987	bacterial-type flagellum assembly
CEJ46_RS10085	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CEJ46_RS10095	COG1677	Flagellar hook-basal body complex protein FliE
CEJ46_RS10115	COG1516	flagellar protein fliS
CEJ46_RS10125	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CEJ46_RS10150	COG2837	iron assimilation
CEJ46_RS10175	COG1393	Belongs to the ArsC family
CEJ46_RS10195	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
CEJ46_RS10210	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CEJ46_RS10215	COG3335	DDE superfamily endonuclease
CEJ46_RS10225	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CEJ46_RS10245	COG4783	chaperone-mediated protein folding
CEJ46_RS10250	COG1393	Belongs to the ArsC family
CEJ46_RS10270	COG2233	PERMEase
CEJ46_RS10275	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CEJ46_RS10285	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CEJ46_RS10290	COG2912	Transglutaminase-like superfamily
CEJ46_RS10295	COG3094	Invasion gene expression up-regulator, SirB
CEJ46_RS10300	COG2890	protein-(glutamine-N5) methyltransferase activity
CEJ46_RS10305	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CEJ46_RS10310	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CEJ46_RS10315	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
CEJ46_RS10320	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CEJ46_RS10325	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CEJ46_RS10330	COG0193	aminoacyl-tRNA hydrolase activity
CEJ46_RS10435	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CEJ46_RS10445	COG3951	Flagellar rod assembly protein muramidase FlgJ
CEJ46_RS10445	COG1705	Flagellar rod assembly protein muramidase FlgJ
CEJ46_RS10450	COG1706	bacterial-type flagellum-dependent cell motility
CEJ46_RS10455	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CEJ46_RS10465	COG4787	bacterial-type flagellum-dependent cell motility
CEJ46_RS10470	COG1749	Flagellar hook protein flgE
CEJ46_RS10485	COG1815	bacterial-type flagellum-dependent cell motility
CEJ46_RS10495	COG0784	Response regulator, receiver
CEJ46_RS10495	COG0835	chemotaxis
CEJ46_RS10505	COG2747	anti-sigma28 factor FlgM
CEJ46_RS10590	COG3335	DDE superfamily endonuclease
CEJ46_RS10640	COG2608	mercury ion transmembrane transporter activity
CEJ46_RS10640	COG2217	Heavy metal translocating P-type atpase
CEJ46_RS10670	COG1187	pseudouridine synthase activity
CEJ46_RS10675	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CEJ46_RS10680	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CEJ46_RS10685	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CEJ46_RS10690	COG0121	glutamine amidotransferase
CEJ46_RS10695	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CEJ46_RS10715	COG0328	RNA-DNA hybrid ribonuclease activity
CEJ46_RS10720	COG2226	methyltransferase
CEJ46_RS10725	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CEJ46_RS10730	COG1388	LysM domain
CEJ46_RS10730	COG0741	lytic transglycosylase activity
CEJ46_RS10740	COG3021	interspecies interaction between organisms
CEJ46_RS10745	COG0347	Belongs to the P(II) protein family
CEJ46_RS10755	COG0037	tRNA processing
CEJ46_RS10760	COG0825	malonyl-CoA metabolic process
CEJ46_RS10765	COG0587	DNA-directed DNA polymerase activity
CEJ46_RS10775	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CEJ46_RS10785	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CEJ46_RS10790	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CEJ46_RS10795	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
CEJ46_RS10805	COG0750	zinc metalloprotease
CEJ46_RS10810	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CEJ46_RS10815	COG0575	Belongs to the CDS family
CEJ46_RS10820	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CEJ46_RS10825	COG0233	cytoplasmic translational termination
CEJ46_RS10835	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CEJ46_RS10840	COG0052	Belongs to the universal ribosomal protein uS2 family
CEJ46_RS10845	COG0024	Methionine aminopeptidase
CEJ46_RS10850	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CEJ46_RS10860	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CEJ46_RS10865	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CEJ46_RS10870	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CEJ46_RS10890	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CEJ46_RS10890	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CEJ46_RS10895	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CEJ46_RS10900	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CEJ46_RS10905	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CEJ46_RS10915	COG1073	alpha beta
CEJ46_RS10920	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CEJ46_RS10925	COG2252	PERMEase
CEJ46_RS10930	COG2195	Cleaves the N-terminal amino acid of tripeptides
CEJ46_RS10935	COG4067	protein conserved in archaea
CEJ46_RS10935	COG0189	ligase activity
CEJ46_RS10940	COG0189	ligase activity
CEJ46_RS10950	COG0733	neurotransmitter:sodium symporter activity
CEJ46_RS10955	COG4251	negative regulation of phosphorylation
CEJ46_RS10955	COG5001	Diguanylate cyclase
CEJ46_RS10955	COG2203	Gaf domain
CEJ46_RS10955	COG3706	GGDEF domain
CEJ46_RS10960	COG3335	DDE superfamily endonuclease
CEJ46_RS10970	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CEJ46_RS10980	COG1477	protein flavinylation
CEJ46_RS11015	COG0271	Belongs to the BolA IbaG family
CEJ46_RS11035	COG2211	Major facilitator Superfamily
CEJ46_RS11045	COG1595	DNA-templated transcription, initiation
CEJ46_RS11060	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CEJ46_RS11070	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CEJ46_RS11075	COG2166	iron-sulfur cluster assembly
CEJ46_RS11080	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CEJ46_RS11085	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
CEJ46_RS11095	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CEJ46_RS11095	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CEJ46_RS11105	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CEJ46_RS11110	COG1074	ATP-dependent DNA helicase activity
CEJ46_RS11115	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CEJ46_RS11130	COG3141	response to X-ray
CEJ46_RS11135	COG2171	N-acyltransferase activity
CEJ46_RS11165	COG1609	Transcriptional regulator
CEJ46_RS11175	COG1085	galactose-1-phosphate uridylyltransferase
CEJ46_RS11180	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CEJ46_RS11185	COG0534	Mate efflux family protein
CEJ46_RS11195	COG3437	response regulator, receiver
CEJ46_RS11195	COG0784	Response regulator, receiver
CEJ46_RS11200	COG1022	Amp-dependent synthetase and ligase
CEJ46_RS11205	COG4628	conserved protein (DUF2132)
CEJ46_RS11210	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CEJ46_RS11215	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CEJ46_RS11225	COG0560	Phosphoserine phosphatase
CEJ46_RS11235	COG0813	purine-nucleoside phosphorylase activity
CEJ46_RS11240	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CEJ46_RS11245	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CEJ46_RS11250	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CEJ46_RS11255	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CEJ46_RS11260	COG0084	hydrolase, TatD family'
CEJ46_RS11265	COG3022	response to hydroperoxide
CEJ46_RS11270	COG1115	amino acid carrier protein
CEJ46_RS11285	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CEJ46_RS11290	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CEJ46_RS11295	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
CEJ46_RS11300	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CEJ46_RS11305	COG0083	homoserine kinase activity
CEJ46_RS11320	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CEJ46_RS11325	COG0745	RESPONSE REGULATOR receiver
CEJ46_RS11335	COG5002	protein histidine kinase activity
CEJ46_RS11335	COG0784	Response regulator, receiver
CEJ46_RS11335	COG2198	Histidine kinase
CEJ46_RS11340	COG1242	4 iron, 4 sulfur cluster binding
CEJ46_RS11345	COG0067	glutamate synthase
CEJ46_RS11345	COG0070	glutamate synthase
CEJ46_RS11345	COG0069	glutamate synthase activity
CEJ46_RS11355	COG0067	glutamate synthase
CEJ46_RS11355	COG0070	glutamate synthase
CEJ46_RS11355	COG0069	glutamate synthase activity
CEJ46_RS11360	COG0493	'glutamate synthase
CEJ46_RS11370	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CEJ46_RS11380	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CEJ46_RS11385	COG2860	membrane
CEJ46_RS11390	COG0583	DNA-binding transcription factor activity
CEJ46_RS11395	COG0730	response to heat
CEJ46_RS11400	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CEJ46_RS11405	COG0505	Belongs to the CarA family
CEJ46_RS11410	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CEJ46_RS11415	COG0494	nUDIX hydrolase
CEJ46_RS11420	COG0653	protein targeting
CEJ46_RS11430	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CEJ46_RS11435	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CEJ46_RS11440	COG0849	cell division
CEJ46_RS11445	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CEJ46_RS11450	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CEJ46_RS11455	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CEJ46_RS11460	COG0772	Belongs to the SEDS family
CEJ46_RS11465	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CEJ46_RS11475	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CEJ46_RS11480	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CEJ46_RS11485	COG0768	penicillin binding
CEJ46_RS11490	COG3116	cell division
CEJ46_RS11495	COG0275	rRNA processing
CEJ46_RS11505	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CEJ46_RS11510	COG3107	peptidoglycan biosynthetic process
CEJ46_RS11515	COG0792	nuclease activity
CEJ46_RS11520	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CEJ46_RS11530	COG2969	positive regulation of protein catabolic process
CEJ46_RS11535	COG0625	glutathione transferase activity
CEJ46_RS11540	COG2857	Cytochrome c1
CEJ46_RS11545	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CEJ46_RS11550	COG0723	plastoquinol--plastocyanin reductase activity
CEJ46_RS11560	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CEJ46_RS11570	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CEJ46_RS11575	COG3105	Protein conserved in bacteria
CEJ46_RS11580	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CEJ46_RS11585	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CEJ46_RS11590	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CEJ46_RS11595	COG0187	DNA topoisomerase II activity
CEJ46_RS11600	COG3150	esterase
CEJ46_RS11610	COG3151	Protein conserved in bacteria
CEJ46_RS11615	COG0494	nUDIX hydrolase
CEJ46_RS11620	COG1538	Outer membrane efflux protein
CEJ46_RS11630	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CEJ46_RS11645	COG3025	triphosphatase activity
CEJ46_RS11650	COG1392	Phosphate transport regulator
CEJ46_RS11655	COG0306	phosphate transporter
CEJ46_RS11660	COG4991	sh3 domain protein
CEJ46_RS11670	COG3267	Type II secretory pathway component ExeA
CEJ46_RS11670	COG3409	Peptidoglycan-binding domain 1 protein
CEJ46_RS11675	COG0617	tRNA 3'-terminal CCA addition
CEJ46_RS11685	COG0504	CTP synthase activity
CEJ46_RS11690	COG3956	TIGRFAM MazG family protein
CEJ46_RS11695	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CEJ46_RS11700	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CEJ46_RS11705	COG3850	Histidine kinase
CEJ46_RS11705	COG3437	response regulator, receiver
CEJ46_RS11705	COG2205	protein histidine kinase activity
CEJ46_RS11705	COG4999	Histidine kinase
CEJ46_RS11710	COG0736	holo-[acyl-carrier-protein] synthase activity
CEJ46_RS11715	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CEJ46_RS11720	COG1381	Involved in DNA repair and RecF pathway recombination
CEJ46_RS11725	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CEJ46_RS11730	COG0571	ribonuclease III activity
CEJ46_RS11740	COG0481	GTPase activity
CEJ46_RS11745	COG3086	response to oxidative stress
CEJ46_RS11760	COG1595	DNA-templated transcription, initiation
CEJ46_RS11765	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CEJ46_RS11775	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
CEJ46_RS11795	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CEJ46_RS11800	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CEJ46_RS11805	COG3079	Belongs to the UPF0149 family
CEJ46_RS11810	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CEJ46_RS11820	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CEJ46_RS11830	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CEJ46_RS11840	COG0028	Belongs to the TPP enzyme family
CEJ46_RS11845	COG1022	Amp-dependent synthetase and ligase
CEJ46_RS11870	COG0473	3-isopropylmalate dehydrogenase activity
CEJ46_RS11880	COG0066	3-isopropylmalate dehydratase activity
CEJ46_RS11945	COG0795	lipopolysaccharide-transporting ATPase activity
CEJ46_RS11950	COG0795	lipopolysaccharide-transporting ATPase activity
CEJ46_RS11955	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CEJ46_RS11960	COG2927	DNA polymerase III (CHI subunit)
CEJ46_RS11965	COG0525	valine-tRNA ligase activity
CEJ46_RS11970	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CEJ46_RS11975	COG0564	pseudouridine synthase activity
CEJ46_RS11985	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CEJ46_RS11995	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CEJ46_RS12010	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
CEJ46_RS12015	COG0251	oxidation-reduction process
CEJ46_RS12030	COG0204	Acyl-transferase
CEJ46_RS12035	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CEJ46_RS12040	COG5007	Belongs to the BolA IbaG family
CEJ46_RS12050	COG2854	intermembrane phospholipid transfer
CEJ46_RS12055	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CEJ46_RS12060	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CEJ46_RS12065	COG1127	ABC transporter
CEJ46_RS12075	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CEJ46_RS12075	COG0517	IMP dehydrogenase activity
CEJ46_RS12090	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
CEJ46_RS12095	COG1137	ATPase activity
CEJ46_RS12105	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CEJ46_RS12110	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CEJ46_RS12115	COG1660	Displays ATPase and GTPase activities
CEJ46_RS12120	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CEJ46_RS12125	COG2239	Acts as a magnesium transporter
CEJ46_RS12130	COG0312	modulator of DNA gyrase
CEJ46_RS12135	COG3028	Belongs to the UPF0307 family
CEJ46_RS12140	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
CEJ46_RS12145	COG1178	ABC-type Fe3 transport system permease component
CEJ46_RS12155	COG0163	prenyltransferase activity
CEJ46_RS12160	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CEJ46_RS12165	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CEJ46_RS12170	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CEJ46_RS12180	COG2105	PFAM AIG2 family protein
CEJ46_RS12185	COG2911	Protein conserved in bacteria
CEJ46_RS12190	COG0729	surface antigen
CEJ46_RS12195	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CEJ46_RS12200	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
CEJ46_RS12235	COG0529	Catalyzes the synthesis of activated sulfate
CEJ46_RS12240	COG2895	sulfate adenylyltransferase (ATP) activity
CEJ46_RS12245	COG0175	sulfate reduction
CEJ46_RS12250	COG1648	precorrin-2 dehydrogenase activity
CEJ46_RS12250	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CEJ46_RS12255	COG0737	Belongs to the 5'-nucleotidase family
CEJ46_RS12295	COG0513	Belongs to the DEAD box helicase family
CEJ46_RS12300	COG2153	protein acetylation
CEJ46_RS12305	COG3061	Opacity-associated protein A
CEJ46_RS12305	COG3266	domain, Protein
CEJ46_RS12310	COG0545	Peptidyl-prolyl cis-trans isomerase
CEJ46_RS12315	COG0203	ribosomal protein L17
CEJ46_RS12320	COG0202	RNA polymerase activity
CEJ46_RS12325	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CEJ46_RS12330	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CEJ46_RS12335	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CEJ46_RS12340	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CEJ46_RS12345	COG0201	protein transport
CEJ46_RS12350	COG0200	Binds to the 23S rRNA
CEJ46_RS12355	COG1841	ribosomal large subunit assembly
CEJ46_RS12360	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CEJ46_RS12370	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CEJ46_RS12375	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CEJ46_RS12380	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CEJ46_RS12385	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CEJ46_RS12390	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CEJ46_RS12400	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CEJ46_RS12410	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CEJ46_RS12425	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CEJ46_RS12430	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CEJ46_RS12440	COG0088	Forms part of the polypeptide exit tunnel
CEJ46_RS12445	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CEJ46_RS12450	COG0051	transcription antitermination factor activity, RNA binding
CEJ46_RS12455	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CEJ46_RS12460	COG0557	exoribonuclease II activity
CEJ46_RS12465	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
CEJ46_RS12475	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CEJ46_RS12485	COG1047	Peptidyl-prolyl cis-trans
CEJ46_RS12490	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
CEJ46_RS12500	COG2249	NAD(P)H dehydrogenase (quinone) activity
CEJ46_RS12505	COG0488	(ABC) transporter
CEJ46_RS12515	COG0429	hydrolase of the alpha beta-hydrolase fold
CEJ46_RS12525	COG3954	Phosphoribulokinase
CEJ46_RS12530	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CEJ46_RS12540	COG1012	belongs to the aldehyde dehydrogenase family
CEJ46_RS12550	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CEJ46_RS12565	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CEJ46_RS12575	COG0583	DNA-binding transcription factor activity
CEJ46_RS12590	COG0180	Tryptophanyl-tRNA synthetase
CEJ46_RS12595	COG0546	phosphoglycolate phosphatase activity
CEJ46_RS12600	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CEJ46_RS12605	COG5433	transposase activity
CEJ46_RS12610	COG0338	D12 class N6 adenine-specific DNA methyltransferase
CEJ46_RS12620	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CEJ46_RS12625	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CEJ46_RS12655	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CEJ46_RS12665	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CEJ46_RS12665	COG0678	peroxiredoxin activity
CEJ46_RS12670	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CEJ46_RS12680	COG0165	Argininosuccinate lyase
CEJ46_RS12680	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CEJ46_RS12685	COG0137	argininosuccinate synthase activity
CEJ46_RS12690	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CEJ46_RS12695	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CEJ46_RS12700	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CEJ46_RS12705	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CEJ46_RS12715	COG1045	serine acetyltransferase
CEJ46_RS12720	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CEJ46_RS12730	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CEJ46_RS12735	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
CEJ46_RS12740	COG1053	succinate dehydrogenase
CEJ46_RS12745	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CEJ46_RS12750	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
CEJ46_RS12760	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CEJ46_RS12765	COG1509	lysine 2,3-aminomutase activity
CEJ46_RS12780	COG0459	protein refolding
CEJ46_RS12785	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CEJ46_RS12815	COG0534	Mate efflux family protein
CEJ46_RS12820	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CEJ46_RS12825	COG1575	Belongs to the MenA family. Type 1 subfamily
CEJ46_RS12835	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CEJ46_RS12845	COG1609	Transcriptional regulator
CEJ46_RS12850	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CEJ46_RS12860	COG0281	malic enzyme
CEJ46_RS12870	COG0626	cystathionine gamma-synthase activity
CEJ46_RS12875	COG0527	aspartate kinase activity
CEJ46_RS12875	COG0460	homoserine dehydrogenase
CEJ46_RS12880	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CEJ46_RS12885	COG3074	FtsZ-dependent cytokinesis
CEJ46_RS12890	COG1494	fructose-1,6-bisphosphatase
CEJ46_RS12895	COG0205	6-phosphofructokinase activity
CEJ46_RS12900	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CEJ46_RS12910	COG0745	RESPONSE REGULATOR receiver
CEJ46_RS12915	COG2205	protein histidine kinase activity
CEJ46_RS12920	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CEJ46_RS12925	COG1278	Cold shock
CEJ46_RS12930	COG3030	protein affecting phage T7 exclusion by the F plasmid
CEJ46_RS12935	COG1027	Aspartate ammonia-lyase
CEJ46_RS12940	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CEJ46_RS12945	COG1288	antiporter activity
CEJ46_RS12955	COG0549	Belongs to the carbamate kinase family
CEJ46_RS12960	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CEJ46_RS12970	COG0540	Belongs to the ATCase OTCase family
CEJ46_RS12975	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
CEJ46_RS12980	COG1438	arginine binding
CEJ46_RS12985	COG4232	protein-disulfide reductase activity
CEJ46_RS13005	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CEJ46_RS13010	COG2205	protein histidine kinase activity
CEJ46_RS13010	COG2198	Histidine kinase
CEJ46_RS13010	COG0784	Response regulator, receiver
CEJ46_RS13015	COG2814	Major facilitator Superfamily
CEJ46_RS13030	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CEJ46_RS13035	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CEJ46_RS13040	COG0511	ligase activity, forming carbon-carbon bonds
CEJ46_RS13045	COG0439	Biotin carboxylase
CEJ46_RS13050	COG2264	protein methyltransferase activity
CEJ46_RS13055	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CEJ46_RS13060	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
CEJ46_RS13065	COG0840	transmembrane signaling receptor activity
CEJ46_RS13070	COG0789	Transcriptional regulator
CEJ46_RS13075	COG0138	bifunctional purine biosynthesis protein purh
CEJ46_RS13080	COG0151	Belongs to the GarS family
CEJ46_RS13090	COG0776	regulation of translation
CEJ46_RS13095	COG1253	flavin adenine dinucleotide binding
CEJ46_RS13100	COG2852	Protein conserved in bacteria
CEJ46_RS13110	COG3068	Protein conserved in bacteria
CEJ46_RS13115	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CEJ46_RS13120	COG0668	transmembrane transport
CEJ46_RS13125	COG0840	transmembrane signaling receptor activity
CEJ46_RS13130	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CEJ46_RS13135	COG5433	transposase activity
CEJ46_RS13140	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CEJ46_RS13145	COG1215	transferase activity, transferring glycosyl groups
CEJ46_RS13165	COG0463	Glycosyl transferase, family 2
CEJ46_RS13185	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CEJ46_RS13210	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CEJ46_RS13220	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CEJ46_RS13245	COG3754	Rhamnan synthesis protein F
CEJ46_RS13295	COG0028	Belongs to the TPP enzyme family
CEJ46_RS13305	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CEJ46_RS13355	COG1682	transport, permease protein
CEJ46_RS13390	COG3307	-O-antigen
CEJ46_RS13395	COG0859	PFAM glycosyl transferase family 9
CEJ46_RS13410	COG1519	Transferase
CEJ46_RS13420	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CEJ46_RS13435	COG3642	lipopolysaccharide core region biosynthetic process
CEJ46_RS13440	COG0859	PFAM glycosyl transferase family 9
CEJ46_RS13445	COG0463	Glycosyl transferase, family 2
CEJ46_RS13450	COG0859	PFAM glycosyl transferase family 9
CEJ46_RS13455	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CEJ46_RS13460	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CEJ46_RS13470	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CEJ46_RS13475	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CEJ46_RS13480	COG2003	Belongs to the UPF0758 family
CEJ46_RS13485	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CEJ46_RS13490	COG1309	transcriptional regulator
CEJ46_RS13495	COG1560	Kdo2-lipid A biosynthetic process
CEJ46_RS13500	COG1560	Kdo2-lipid A biosynthetic process
CEJ46_RS13505	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CEJ46_RS13510	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CEJ46_RS13515	COG1561	YicC-like family, N-terminal region
CEJ46_RS13530	COG1396	sequence-specific DNA binding
CEJ46_RS13550	COG0612	Peptidase, M16
CEJ46_RS13555	COG2862	Uncharacterized protein family, UPF0114
CEJ46_RS13570	COG1120	ATPase activity
CEJ46_RS13575	COG4774	siderophore transport
CEJ46_RS13580	COG1132	(ABC) transporter
CEJ46_RS13585	COG1263	PTS System
CEJ46_RS13585	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CEJ46_RS13590	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CEJ46_RS13610	COG0514	ATP-dependent DNA helicase (RecQ)
CEJ46_RS13615	COG2962	Rard protein
CEJ46_RS13620	COG0405	Gamma-glutamyltransferase
CEJ46_RS13630	COG1280	lysine exporter protein (LysE YggA)
CEJ46_RS13635	COG0210	DNA helicase
CEJ46_RS13640	COG0339	signal peptide processing
CEJ46_RS13645	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CEJ46_RS13650	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CEJ46_RS13675	COG0840	transmembrane signaling receptor activity
CEJ46_RS13700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CEJ46_RS13705	COG0601	transmembrane transport
CEJ46_RS13755	COG1309	transcriptional regulator
CEJ46_RS13760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CEJ46_RS13765	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CEJ46_RS13770	COG2960	long-chain fatty acid transporting porin activity
CEJ46_RS13775	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CEJ46_RS13785	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CEJ46_RS13795	COG3078	GTPase activator activity
CEJ46_RS13815	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CEJ46_RS13815	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CEJ46_RS13825	COG0084	hydrolase, TatD family'
CEJ46_RS13830	COG0805	protein transport
CEJ46_RS13835	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CEJ46_RS13840	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CEJ46_RS13845	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CEJ46_RS13855	COG2226	methyltransferase
CEJ46_RS13860	COG1322	Protein conserved in bacteria
CEJ46_RS13880	COG2160	L-arabinose isomerase activity
CEJ46_RS13890	COG1069	ribulokinase activity
CEJ46_RS13900	COG1879	ABC-type sugar transport system periplasmic component
CEJ46_RS13905	COG1129	ABC transporter
CEJ46_RS13910	COG1172	Belongs to the binding-protein-dependent transport system permease family
CEJ46_RS14110	COG2081	HI0933 family
CEJ46_RS14125	COG1528	Iron-storage protein
CEJ46_RS14130	COG0589	response to stress
CEJ46_RS14145	COG0742	ribosomal rna small subunit methyltransferase
CEJ46_RS14150	COG1522	sequence-specific DNA binding
CEJ46_RS14170	COG0006	proline dipeptidase activity
CEJ46_RS14170	COG0006	proline dipeptidase activity
CEJ46_RS14175	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CEJ46_RS14180	COG2022	thiamine diphosphate biosynthetic process
CEJ46_RS14185	COG2104	thiamine diphosphate biosynthetic process
CEJ46_RS14190	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CEJ46_RS14195	COG0352	thiamine-phosphate diphosphorylase activity
CEJ46_RS14285	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
CEJ46_RS14290	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CEJ46_RS14295	COG1739	Uncharacterized protein family UPF0029
CEJ46_RS14305	COG0183	Belongs to the thiolase family
CEJ46_RS14310	COG0583	DNA-binding transcription factor activity
CEJ46_RS14315	COG2814	Major facilitator Superfamily
CEJ46_RS14325	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CEJ46_RS14330	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CEJ46_RS14335	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CEJ46_RS14340	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CEJ46_RS14345	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CEJ46_RS14350	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CEJ46_RS14365	COG3312	ion transport
CEJ46_RS14370	COG1475	DNA binding
CEJ46_RS14375	COG1192	Involved in chromosome partitioning
CEJ46_RS14385	COG0445	tRNA wobble uridine modification
CEJ46_RS14415	COG2084	Dehydrogenase
CEJ46_RS14420	COG0814	amino acid
CEJ46_RS14450	COG0583	DNA-binding transcription factor activity
CEJ46_RS14455	COG2910	NAD(P)H-binding
CEJ46_RS14465	COG3304	Inner membrane component domain
CEJ46_RS14485	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CEJ46_RS14490	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CEJ46_RS14510	COG0363	glucosamine-6-phosphate deaminase activity
CEJ46_RS14520	COG0739	heme binding
CEJ46_RS14525	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CEJ46_RS14525	COG2213	PTS system mannitol-specific
CEJ46_RS14530	COG0246	Mannitol dehydrogenase
CEJ46_RS14535	COG3722	fumarate hydratase activity
CEJ46_RS14545	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CEJ46_RS14550	COG1301	dicarboxylic acid transport
CEJ46_RS14555	COG2259	Doxx family
CEJ46_RS14580	COG1846	Transcriptional regulator
CEJ46_RS14590	COG3046	protein related to deoxyribodipyrimidine photolyase
CEJ46_RS14595	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CEJ46_RS14600	COG0842	Transport permease protein
CEJ46_RS14605	COG1131	(ABC) transporter
CEJ46_RS14620	COG3842	ATPase activity
CEJ46_RS14630	COG1175	transmembrane transport
CEJ46_RS14650	COG0513	Belongs to the DEAD box helicase family
CEJ46_RS14655	COG0251	oxidation-reduction process
CEJ46_RS14660	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CEJ46_RS14670	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CEJ46_RS14675	COG1328	CTP reductase activity
CEJ46_RS14685	COG2130	NADP-dependent
CEJ46_RS14690	COG1309	transcriptional regulator
CEJ46_RS14705	COG0745	RESPONSE REGULATOR receiver
CEJ46_RS14715	COG0564	pseudouridine synthase activity
CEJ46_RS14775	COG3829	transcription factor binding
CEJ46_RS14800	COG3501	Rhs element vgr protein
CEJ46_RS14850	COG0471	metal ion transport
CEJ46_RS14855	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
CEJ46_RS14865	COG2188	Transcriptional regulator
CEJ46_RS14870	COG1131	(ABC) transporter
CEJ46_RS14880	COG0840	transmembrane signaling receptor activity
CEJ46_RS14900	COG0671	phosphoesterase, PA-phosphatase related
CEJ46_RS14910	COG1132	(ABC) transporter
CEJ46_RS14930	COG3623	hexulose-6-phosphate isomerase
CEJ46_RS14935	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
CEJ46_RS14940	COG0561	phosphatase activity
CEJ46_RS14975	COG4580	involved in the transport of maltose and maltodextrins
CEJ46_RS14985	COG0366	Alpha amylase catalytic
CEJ46_RS14995	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CEJ46_RS15005	COG1999	signal sequence binding
CEJ46_RS15020	COG0786	glutamate:sodium symporter activity
CEJ46_RS15045	COG1566	PFAM secretion protein HlyD family protein
CEJ46_RS15070	COG0813	purine-nucleoside phosphorylase activity
CEJ46_RS15075	COG3272	Protein of unknown function (DUF1722)
CEJ46_RS15080	COG0789	Transcriptional regulator
CEJ46_RS15085	COG0415	Belongs to the DNA photolyase family
CEJ46_RS15090	COG1376	ErfK ybiS ycfS ynhG family protein
CEJ46_RS15090	COG1388	LysM domain
CEJ46_RS15100	COG0513	Belongs to the DEAD box helicase family
CEJ46_RS15110	COG5433	transposase activity
CEJ46_RS15140	COG2267	carboxylic ester hydrolase activity
CEJ46_RS15150	COG0366	Alpha amylase catalytic
CEJ46_RS15155	COG4989	oxidoreductase activity
CEJ46_RS15165	COG0577	efflux transmembrane transporter activity
CEJ46_RS15165	COG1136	(ABC) transporter
CEJ46_RS15170	COG4591	ABC-type transport system involved in lipoprotein release permease component
CEJ46_RS15185	COG0745	RESPONSE REGULATOR receiver
CEJ46_RS15185	COG2972	Histidine kinase
CEJ46_RS15190	COG3279	Response regulator of the LytR AlgR family
CEJ46_RS15195	COG4251	negative regulation of phosphorylation
CEJ46_RS15195	COG2203	Gaf domain
CEJ46_RS15195	COG3706	GGDEF domain
CEJ46_RS15195	COG5001	Diguanylate cyclase
CEJ46_RS15205	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CEJ46_RS15215	COG3437	response regulator, receiver
CEJ46_RS15220	COG3850	Histidine kinase
CEJ46_RS15220	COG2205	protein histidine kinase activity
CEJ46_RS15220	COG3437	response regulator, receiver
CEJ46_RS15220	COG4999	Histidine kinase
CEJ46_RS15230	COG0531	amino acid
CEJ46_RS15245	COG1151	hydroxylamine reductase activity
CEJ46_RS15250	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CEJ46_RS15260	COG2205	protein histidine kinase activity
CEJ46_RS15260	COG5002	protein histidine kinase activity
CEJ46_RS15260	COG0784	Response regulator, receiver
CEJ46_RS15275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CEJ46_RS15280	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CEJ46_RS15295	COG0673	inositol 2-dehydrogenase activity
CEJ46_RS15300	COG1765	OsmC-like protein
CEJ46_RS15305	COG0110	maltose O-acetyltransferase activity
CEJ46_RS15320	COG0583	DNA-binding transcription factor activity
CEJ46_RS15330	COG0583	DNA-binding transcription factor activity
CEJ46_RS15335	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CEJ46_RS15340	COG3186	Phenylalanine-4-hydroxylase
CEJ46_RS15345	COG2154	pterin-4-alpha-carbinolamine dehydratase
CEJ46_RS15355	COG0534	Mate efflux family protein
CEJ46_RS15360	COG2207	Transcriptional regulator
CEJ46_RS15365	COG3437	response regulator, receiver
CEJ46_RS15365	COG0784	Response regulator, receiver
CEJ46_RS15370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CEJ46_RS15370	COG4191	Histidine kinase
CEJ46_RS15380	COG2814	Major facilitator Superfamily
CEJ46_RS15390	COG0443	Heat shock 70 kDa protein
CEJ46_RS15405	COG3240	lipase activity
CEJ46_RS15415	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
CEJ46_RS15420	COG5380	lipid catabolic process
CEJ46_RS15450	COG4607	ABC-type enterochelin transport system periplasmic component
CEJ46_RS15455	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CEJ46_RS15460	COG4605	iron ion homeostasis
CEJ46_RS15465	COG4604	ABC transporter, ATP-binding protein
CEJ46_RS15470	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CEJ46_RS15480	COG2153	protein acetylation
CEJ46_RS15485	COG0697	spore germination
CEJ46_RS15490	COG0387	Pfam Sodium calcium exchanger
CEJ46_RS15495	COG0861	Integral membrane protein TerC family
CEJ46_RS15505	COG2161	toxin-antitoxin pair type II binding
CEJ46_RS15530	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CEJ46_RS15535	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CEJ46_RS15570	COG0509	glycine decarboxylation via glycine cleavage system
CEJ46_RS15575	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CEJ46_RS15585	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CEJ46_RS15600	COG0612	Peptidase, M16
CEJ46_RS15615	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CEJ46_RS15615	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CEJ46_RS15615	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
CEJ46_RS15620	COG1105	Belongs to the carbohydrate kinase PfkB family
CEJ46_RS15625	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CEJ46_RS15625	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CEJ46_RS15630	COG1609	Transcriptional regulator
CEJ46_RS15635	COG0420	3'-5' exonuclease activity
CEJ46_RS15640	COG0419	ATPase involved in DNA repair
CEJ46_RS15645	COG2205	protein histidine kinase activity
CEJ46_RS15645	COG0784	Response regulator, receiver
CEJ46_RS15650	COG0156	8-amino-7-oxononanoate synthase activity
CEJ46_RS15660	COG0038	chloride channel
CEJ46_RS15665	COG0523	cobalamin synthesis protein
CEJ46_RS15670	COG1136	(ABC) transporter
CEJ46_RS15680	COG1136	(ABC) transporter
CEJ46_RS15680	COG0577	efflux transmembrane transporter activity
CEJ46_RS15695	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CEJ46_RS15705	COG3675	Pfam Lipase (class 3)
CEJ46_RS15720	COG5433	transposase activity
CEJ46_RS15735	COG3730	PTS system glucitol sorbitol-specific
CEJ46_RS15750	COG1028	Short-chain dehydrogenase reductase Sdr
CEJ46_RS15755	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
CEJ46_RS15760	COG1349	DNA-binding transcription factor activity
CEJ46_RS15765	COG3730	PTS system glucitol sorbitol-specific
CEJ46_RS15780	COG3842	ATPase activity
CEJ46_RS15790	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CEJ46_RS15800	COG2182	Extracellular solute-binding protein
CEJ46_RS15805	COG1175	transmembrane transport
CEJ46_RS15810	COG3833	ABC-type maltose transport systems, permease component
CEJ46_RS15835	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CEJ46_RS15840	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CEJ46_RS15850	COG3005	denitrification pathway
CEJ46_RS15860	COG0243	molybdopterin cofactor binding
CEJ46_RS15870	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CEJ46_RS15875	COG3850	Histidine kinase
CEJ46_RS15880	COG2197	response regulator
CEJ46_RS15885	COG3069	C4-dicarboxylate transmembrane transporter activity
CEJ46_RS15910	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CEJ46_RS15920	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
CEJ46_RS15925	COG0513	Belongs to the DEAD box helicase family
CEJ46_RS16015	COG1028	Short-chain dehydrogenase reductase Sdr
CEJ46_RS16295	COG3041	Addiction module toxin RelE StbE family
CEJ46_RS16340	COG0724	RNA recognition motif
CEJ46_RS16680	COG3040	lipid binding
CEJ46_RS16685	COG5433	transposase activity
CEJ46_RS16810	COG0346	lactoylglutathione lyase activity
CEJ46_RS16825	COG0346	lactoylglutathione lyase activity
CEJ46_RS16865	COG0583	DNA-binding transcription factor activity
CEJ46_RS16965	COG3335	DDE superfamily endonuclease
CEJ46_RS16970	COG5433	transposase activity
CEJ46_RS17030	COG1028	Short-chain dehydrogenase reductase Sdr
CEJ46_RS17095	COG5433	transposase activity
CEJ46_RS17115	COG0023	Translation Initiation Factor
CEJ46_RS17130	COG1181	Belongs to the D-alanine--D-alanine ligase family
CEJ46_RS17140	COG1042	CoA-binding domain protein
CEJ46_RS17140	COG0045	succinate-CoA ligase (ADP-forming) activity
CEJ46_RS17140	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CEJ46_RS17145	COG0583	DNA-binding transcription factor activity
CEJ46_RS17175	COG3140	Belongs to the UPF0181 family
CEJ46_RS17190	COG0745	RESPONSE REGULATOR receiver
CEJ46_RS17200	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CEJ46_RS17205	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CEJ46_RS17220	COG3706	GGDEF domain
CEJ46_RS17225	COG1278	Cold shock
CEJ46_RS17235	COG0840	transmembrane signaling receptor activity
CEJ46_RS17250	COG2501	S4 domain
CEJ46_RS17255	COG0625	glutathione transferase activity
CEJ46_RS17260	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CEJ46_RS17265	COG0488	(ABC) transporter
CEJ46_RS17280	COG2050	protein possibly involved in aromatic compounds catabolism
CEJ46_RS17290	COG2824	Alkylphosphonate utilization operon protein PhnA
CEJ46_RS17300	COG0861	Integral membrane protein TerC family
CEJ46_RS17305	COG0737	Belongs to the 5'-nucleotidase family
CEJ46_RS17310	COG3593	DNA synthesis involved in DNA repair
CEJ46_RS17320	COG0583	DNA-binding transcription factor activity
CEJ46_RS17325	COG2116	formate transmembrane transporter activity
CEJ46_RS17335	COG3104	oligopeptide transport
CEJ46_RS17345	COG2188	Transcriptional regulator
CEJ46_RS17350	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CEJ46_RS17355	COG1011	Hydrolase
CEJ46_RS17360	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
CEJ46_RS17365	COG5433	transposase activity
CEJ46_RS17370	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CEJ46_RS17375	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CEJ46_RS17380	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CEJ46_RS17385	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CEJ46_RS17385	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CEJ46_RS17390	COG0302	gtp cyclohydrolase
CEJ46_RS17395	COG0303	'Molybdopterin
CEJ46_RS17400	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CEJ46_RS17405	COG2897	thiosulfate sulfurtransferase activity
CEJ46_RS17425	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CEJ46_RS17440	COG0545	Peptidyl-prolyl cis-trans isomerase
CEJ46_RS17445	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CEJ46_RS17450	COG0840	transmembrane signaling receptor activity
CEJ46_RS17455	COG2353	YceI-like domain
CEJ46_RS17460	COG3038	cytochrome b561
CEJ46_RS17470	COG3706	GGDEF domain
CEJ46_RS17470	COG4251	negative regulation of phosphorylation
CEJ46_RS17470	COG5001	Diguanylate cyclase
CEJ46_RS17470	COG2203	Gaf domain
CEJ46_RS17475	COG4172	Belongs to the ABC transporter superfamily
CEJ46_RS17480	COG4239	(ABC) transporter, permease
CEJ46_RS17485	COG4174	ABC transporter (Permease)
CEJ46_RS17490	COG4166	transmembrane transport
CEJ46_RS17505	COG4067	protein conserved in archaea
CEJ46_RS17505	COG0189	ligase activity
CEJ46_RS17515	COG0602	queuosine metabolic process
CEJ46_RS17520	COG1328	CTP reductase activity
CEJ46_RS17525	COG3706	GGDEF domain
CEJ46_RS17530	COG5433	transposase activity
CEJ46_RS17575	COG3300	MHYT domain
CEJ46_RS17575	COG5001	Diguanylate cyclase
CEJ46_RS17580	COG4191	Histidine kinase
CEJ46_RS17585	COG3852	Histidine kinase
CEJ46_RS17610	COG3706	GGDEF domain
CEJ46_RS17615	COG3335	DDE superfamily endonuclease
CEJ46_RS17620	COG0745	RESPONSE REGULATOR receiver
CEJ46_RS17630	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CEJ46_RS17635	COG4149	molybdate abc transporter
CEJ46_RS17640	COG0725	ABC transporter, periplasmic molybdate-binding protein
CEJ46_RS17645	COG1492	cobalamin metabolic process
CEJ46_RS17650	COG3111	PFAM Bacterial OB fold (BOF) protein
CEJ46_RS17665	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CEJ46_RS17675	COG2207	Transcriptional regulator
CEJ46_RS17680	COG1979	alcohol dehydrogenase
CEJ46_RS17715	COG2205	protein histidine kinase activity
CEJ46_RS17715	COG0784	Response regulator, receiver
CEJ46_RS17715	COG2198	Histidine kinase
CEJ46_RS17720	COG1879	ABC-type sugar transport system periplasmic component
CEJ46_RS17725	COG1803	Methylglyoxal synthase
CEJ46_RS17730	COG0210	DNA helicase
CEJ46_RS17735	COG1289	transmembrane transporter activity
CEJ46_RS17765	COG5002	protein histidine kinase activity
CEJ46_RS17765	COG0784	Response regulator, receiver
CEJ46_RS17780	COG2827	Endonuclease containing a URI domain
CEJ46_RS17785	COG3132	Protein of unknown function, DUF480
CEJ46_RS17805	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CEJ46_RS17810	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CEJ46_RS17815	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CEJ46_RS17820	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
CEJ46_RS17825	COG0247	lactate metabolic process
CEJ46_RS17830	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CEJ46_RS17835	COG3118	belongs to the thioredoxin family
CEJ46_RS17855	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CEJ46_RS17860	COG1648	precorrin-2 dehydrogenase activity
CEJ46_RS17860	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CEJ46_RS17875	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CEJ46_RS17885	COG1335	isochorismatase
CEJ46_RS17895	COG3335	DDE superfamily endonuclease
CEJ46_RS17900	COG1982	Orn Lys Arg decarboxylase major
CEJ46_RS17905	COG0697	spore germination
CEJ46_RS17950	COG2425	protein containing a von Willebrand factor type A (vWA) domain
CEJ46_RS17965	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
CEJ46_RS17975	COG0513	Belongs to the DEAD box helicase family
CEJ46_RS17980	COG0814	amino acid
CEJ46_RS17990	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CEJ46_RS17995	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CEJ46_RS18005	COG1984	allophanate hydrolase subunit 2
CEJ46_RS18015	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
CEJ46_RS18020	COG4181	ATPase activity
CEJ46_RS18030	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CEJ46_RS18035	COG5001	Diguanylate cyclase
CEJ46_RS18035	COG1716	ATPase activity
CEJ46_RS18045	COG0484	heat shock protein binding
CEJ46_RS18065	COG0784	Response regulator, receiver
CEJ46_RS18065	COG3437	response regulator, receiver
CEJ46_RS18115	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CEJ46_RS18120	COG5001	Diguanylate cyclase
CEJ46_RS18120	COG3300	MHYT domain
CEJ46_RS18140	COG0010	Belongs to the arginase family
CEJ46_RS18145	COG1166	arginine decarboxylase activity
CEJ46_RS18160	COG4176	ABC-type proline glycine betaine transport system permease component
CEJ46_RS18165	COG2113	Glycine betaine
CEJ46_RS18185	COG0527	aspartate kinase activity
CEJ46_RS18190	COG0662	Cupin 2, conserved barrel domain protein
CEJ46_RS18195	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CEJ46_RS18200	COG0456	acetyltransferase
CEJ46_RS18210	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CEJ46_RS18215	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CEJ46_RS18250	COG0366	Alpha amylase catalytic
CEJ46_RS18270	COG0714	Associated with various cellular activities
CEJ46_RS18290	COG2304	oxidoreductase activity
CEJ46_RS18305	COG3706	GGDEF domain
CEJ46_RS18320	COG3530	Putative quorum-sensing-regulated virulence factor
CEJ46_RS18325	COG1368	sulfuric ester hydrolase activity
CEJ46_RS18335	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CEJ46_RS18340	COG3227	Zinc metalloprotease (Elastase)
CEJ46_RS18355	COG2258	MOSC domain
CEJ46_RS18385	COG1063	alcohol dehydrogenase
CEJ46_RS18390	COG0156	8-amino-7-oxononanoate synthase activity
CEJ46_RS18400	COG0346	lactoylglutathione lyase activity
CEJ46_RS18415	COG2197	response regulator
CEJ46_RS18420	COG3851	Histidine kinase
CEJ46_RS18425	COG2271	Major facilitator Superfamily
CEJ46_RS18435	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CEJ46_RS18460	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CEJ46_RS18465	COG0640	Transcriptional regulator
CEJ46_RS18470	COG0798	PFAM Bile acid sodium symporter
CEJ46_RS18475	COG0640	Transcriptional regulator
CEJ46_RS18480	COG0659	secondary active sulfate transmembrane transporter activity
CEJ46_RS18485	COG0589	response to stress
CEJ46_RS18510	COG4977	sequence-specific DNA binding
CEJ46_RS18510	COG1917	Cupin 2, conserved barrel domain protein
CEJ46_RS18515	COG4771	TonB-dependent receptor
CEJ46_RS18520	COG2814	Major facilitator Superfamily
CEJ46_RS18525	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CEJ46_RS18525	COG2226	methyltransferase
CEJ46_RS18525	COG3433	isochorismatase activity
CEJ46_RS18550	COG1021	2,3-dihydroxybenzoate-AMP ligase
CEJ46_RS18555	COG1132	(ABC) transporter
CEJ46_RS18560	COG1132	(ABC) transporter
CEJ46_RS18570	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CEJ46_RS18595	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CEJ46_RS18605	COG0642	Histidine kinase
CEJ46_RS18610	COG4753	response regulator
CEJ46_RS18610	COG2207	Transcriptional regulator
CEJ46_RS18650	COG3335	DDE superfamily endonuclease
CEJ46_RS18690	COG0714	Associated with various cellular activities
CEJ46_RS18725	COG1196	nuclear chromosome segregation
CEJ46_RS18735	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CEJ46_RS18745	COG2204	response regulator
CEJ46_RS18800	COG3501	Rhs element vgr protein
CEJ46_RS18845	COG0516	GMP reductase activity
CEJ46_RS18850	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CEJ46_RS18875	COG1278	Cold shock
CEJ46_RS18880	COG4681	YaeQ
CEJ46_RS18885	COG1017	nitric oxide dioxygenase activity
CEJ46_RS18885	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CEJ46_RS18890	COG3604	Transcriptional regulator
CEJ46_RS18900	COG2195	Cleaves the N-terminal amino acid of tripeptides
CEJ46_RS18905	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CEJ46_RS18910	COG3217	Mosc domain protein beta barrel domain protein
CEJ46_RS18910	COG0633	Ferredoxin
CEJ46_RS18915	COG0418	dihydroorotase activity
CEJ46_RS18920	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CEJ46_RS18925	COG2354	Protein conserved in bacteria
CEJ46_RS18950	COG2199	diguanylate cyclase activity
CEJ46_RS18955	COG1349	DNA-binding transcription factor activity
CEJ46_RS18980	COG3833	ABC-type maltose transport systems, permease component
CEJ46_RS18985	COG1175	transmembrane transport
CEJ46_RS19000	COG3842	ATPase activity
CEJ46_RS19010	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CEJ46_RS19015	COG0784	Response regulator, receiver
CEJ46_RS19015	COG0835	chemotaxis
CEJ46_RS19020	COG2315	Protein conserved in bacteria
CEJ46_RS19025	COG3706	GGDEF domain
CEJ46_RS19060	COG5001	Diguanylate cyclase
CEJ46_RS19070	COG1741	Belongs to the pirin family
CEJ46_RS19080	COG3123	guanosine phosphorylase activity
CEJ46_RS19090	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CEJ46_RS19100	COG0765	amino acid transport
CEJ46_RS19105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CEJ46_RS19110	COG0765	amino acid transport
CEJ46_RS19115	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CEJ46_RS19130	COG0179	Fumarylacetoacetate (FAA) hydrolase
CEJ46_RS19140	COG0697	spore germination
CEJ46_RS19160	COG2814	Major facilitator Superfamily
CEJ46_RS19165	COG0583	DNA-binding transcription factor activity
CEJ46_RS19170	COG5001	Diguanylate cyclase
CEJ46_RS19175	COG0739	heme binding
CEJ46_RS19185	COG0659	secondary active sulfate transmembrane transporter activity
CEJ46_RS19190	COG3314	Sporulation integral membrane protein YlbJ
CEJ46_RS19205	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CEJ46_RS19210	COG0581	inorganic phosphate transmembrane transporter activity
CEJ46_RS19215	COG0573	inorganic phosphate transmembrane transporter activity
CEJ46_RS19220	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CEJ46_RS19230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CEJ46_RS19235	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CEJ46_RS19255	COG3047	cAMP biosynthetic process
CEJ46_RS19270	COG2271	Major facilitator Superfamily
CEJ46_RS19275	COG0584	glycerophosphoryl diester phosphodiesterase
CEJ46_RS19285	COG3527	Alpha-acetolactate decarboxylase
CEJ46_RS19300	COG0488	(ABC) transporter
CEJ46_RS19310	COG3708	Transcriptional regulator
CEJ46_RS19310	COG2207	Transcriptional regulator
CEJ46_RS19315	COG0583	DNA-binding transcription factor activity
CEJ46_RS19320	COG1620	l-lactate permease
CEJ46_RS19340	COG1881	PFAM PEBP family protein
CEJ46_RS19345	COG3122	Protein conserved in bacteria
CEJ46_RS19355	COG3568	Endonuclease Exonuclease Phosphatase
CEJ46_RS19370	COG0840	transmembrane signaling receptor activity
CEJ46_RS19385	COG1609	Transcriptional regulator
CEJ46_RS19390	COG1472	Belongs to the glycosyl hydrolase 3 family
CEJ46_RS19395	COG3842	ATPase activity
CEJ46_RS19400	COG0395	ABC-type sugar transport system, permease component
CEJ46_RS19405	COG1175	transmembrane transport
CEJ46_RS19415	COG1609	Transcriptional regulator
CEJ46_RS19420	COG4580	involved in the transport of maltose and maltodextrins
CEJ46_RS19440	COG2211	Major facilitator Superfamily
CEJ46_RS19450	COG1067	ATP-dependent peptidase activity
CEJ46_RS19460	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CEJ46_RS19465	COG0363	glucosamine-6-phosphate deaminase activity
CEJ46_RS19485	COG1609	Transcriptional regulator
CEJ46_RS19490	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CEJ46_RS19495	COG1879	ABC-type sugar transport system periplasmic component
CEJ46_RS19500	COG1172	Belongs to the binding-protein-dependent transport system permease family
CEJ46_RS19505	COG1129	ABC transporter
CEJ46_RS19510	COG1869	D-ribose catabolic process
CEJ46_RS19535	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CEJ46_RS19540	COG1640	4-alpha-glucanotransferase
CEJ46_RS19545	COG0058	SHG alpha-glucan phosphorylase activity
CEJ46_RS19550	COG2909	trisaccharide binding
CEJ46_RS19575	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CEJ46_RS19595	COG0840	transmembrane signaling receptor activity
CEJ46_RS19630	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CEJ46_RS19640	COG0259	pyridoxamine-phosphate oxidase activity
CEJ46_RS19690	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CEJ46_RS19695	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CEJ46_RS19700	COG0840	transmembrane signaling receptor activity
CEJ46_RS19710	COG0835	chemotaxis
CEJ46_RS19715	COG0643	Histidine kinase
CEJ46_RS19715	COG2198	Histidine kinase
CEJ46_RS19720	COG0745	RESPONSE REGULATOR receiver
CEJ46_RS19730	COG1444	tRNA N-acetyltransferase activity
CEJ46_RS19735	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine