locus-tag	class	description
A6A12_RS00010	COG0592	DNA-directed DNA polymerase activity
A6A12_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A6A12_RS00020	COG0187	DNA topoisomerase II activity
A6A12_RS00035	COG0071	Belongs to the small heat shock protein (HSP20) family
A6A12_RS00040	COG3977	Valine--pyruvate aminotransferase
A6A12_RS00050	COG0752	glycyl-tRNA synthetase alpha subunit
A6A12_RS00055	COG2119	membrane
A6A12_RS00065	COG0425	Belongs to the sulfur carrier protein TusA family
A6A12_RS00080	COG0604	alcohol dehydrogenase
A6A12_RS00095	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A6A12_RS00100	COG3978	acetolactate synthase activity
A6A12_RS00110	COG0606	chelatase, subunit chli
A6A12_RS00185	COG2433	Pfam Transposase IS66
A6A12_RS00205	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A6A12_RS00210	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A6A12_RS00225	COG3084	Protein conserved in bacteria
A6A12_RS00235	COG1272	protein, Hemolysin III
A6A12_RS00245	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A6A12_RS00250	COG0569	domain protein
A6A12_RS00255	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A6A12_RS00255	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A6A12_RS00260	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A6A12_RS00265	COG0242	peptide deformylase activity
A6A12_RS00270	COG1652	LysM domain
A6A12_RS00275	COG0758	DNA mediated transformation
A6A12_RS00280	COG2922	Belongs to the Smg family
A6A12_RS00285	COG0551	DNA topoisomerase type I activity
A6A12_RS00290	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A6A12_RS00295	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A6A12_RS00300	COG0009	L-threonylcarbamoyladenylate synthase
A6A12_RS00305	COG0408	coproporphyrinogen oxidase activity
A6A12_RS00310	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A6A12_RS00320	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A6A12_RS00355	COG3071	HemY protein
A6A12_RS00360	COG2959	enzyme of heme biosynthesis
A6A12_RS00365	COG1587	Uroporphyrinogen-III synthase
A6A12_RS00390	COG0019	diaminopimelate decarboxylase activity
A6A12_RS00395	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A6A12_RS00405	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
A6A12_RS00410	COG1011	Hydrolase
A6A12_RS00415	COG3148	PFAM DTW domain containing protein
A6A12_RS00425	COG0561	phosphatase activity
A6A12_RS00430	COG2267	carboxylic ester hydrolase activity
A6A12_RS00435	COG1280	lysine exporter protein (LysE YggA)
A6A12_RS00440	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
A6A12_RS00445	COG0783	Belongs to the Dps family
A6A12_RS00475	COG2095	MarC family integral membrane protein
A6A12_RS00490	COG2433	Pfam Transposase IS66
A6A12_RS00535	COG0742	ribosomal rna small subunit methyltransferase
A6A12_RS00540	COG0552	protein localization to endoplasmic reticulum
A6A12_RS00545	COG2884	Cell division ATP-binding protein ftsE
A6A12_RS00550	COG2177	Part of the ABC transporter FtsEX involved in
A6A12_RS00555	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A6A12_RS00565	COG0705	Rhomboid family
A6A12_RS00570	COG1580	Controls the rotational direction of flagella during chemotaxis
A6A12_RS00575	COG3161	chorismate lyase activity
A6A12_RS00585	COG2937	Belongs to the GPAT DAPAT family
A6A12_RS00590	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A6A12_RS00600	COG0534	Mate efflux family protein
A6A12_RS00605	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6A12_RS00625	COG3250	beta-galactosidase activity
A6A12_RS00660	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A6A12_RS00700	COG3550	peptidyl-serine autophosphorylation
A6A12_RS00745	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A6A12_RS00785	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A6A12_RS00790	COG5001	Diguanylate cyclase
A6A12_RS00790	COG3300	MHYT domain
A6A12_RS00800	COG3852	Histidine kinase
A6A12_RS00810	COG0174	glutamine synthetase
A6A12_RS00815	COG1217	gtp-binding protein TYPA
A6A12_RS00820	COG1295	ribonuclease BN
A6A12_RS00825	COG1490	D-aminoacyl-tRNA deacylase activity
A6A12_RS00830	COG0456	acetyltransferase
A6A12_RS00840	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
A6A12_RS00845	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
A6A12_RS00850	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A6A12_RS00855	COG3031	protein transport across the cell outer membrane
A6A12_RS00865	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A6A12_RS00870	COG1459	type II secretion system
A6A12_RS00875	COG2165	general secretion pathway protein
A6A12_RS00880	COG2165	general secretion pathway protein
A6A12_RS00885	COG2165	general secretion pathway protein
A6A12_RS00890	COG4795	General secretion pathway protein
A6A12_RS00895	COG3156	type II secretion system protein K
A6A12_RS00900	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
A6A12_RS00905	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
A6A12_RS00915	COG1218	3'(2'),5'-bisphosphate nucleotidase
A6A12_RS00920	COG0494	nUDIX hydrolase
A6A12_RS00925	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
A6A12_RS00925	COG0316	Belongs to the HesB IscA family
A6A12_RS00930	COG1040	competence protein
A6A12_RS00935	COG0596	Alpha beta hydrolase
A6A12_RS00945	COG2183	response to ionizing radiation
A6A12_RS00950	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A6A12_RS00970	COG0583	DNA-binding transcription factor activity
A6A12_RS01005	COG2233	PERMEase
A6A12_RS01010	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A6A12_RS01015	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A6A12_RS01020	COG1758	RNA polymerase activity
A6A12_RS01025	COG0194	GDP metabolic process
A6A12_RS01030	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
A6A12_RS01035	COG0248	Ppx GppA phosphatase
A6A12_RS01045	COG3118	belongs to the thioredoxin family
A6A12_RS01060	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
A6A12_RS01105	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A6A12_RS01115	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A6A12_RS01120	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
A6A12_RS01120	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
A6A12_RS01125	COG1072	(Pantothenic acid kinase))
A6A12_RS01155	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A6A12_RS01160	COG0250	Participates in transcription elongation, termination and antitermination
A6A12_RS01175	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A6A12_RS01180	COG0222	ribosome binding
A6A12_RS01185	COG0085	RNA polymerase activity
A6A12_RS01190	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A6A12_RS01195	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
A6A12_RS01200	COG2816	NAD+ diphosphatase activity
A6A12_RS01205	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A6A12_RS01220	COG4942	peptidase
A6A12_RS01225	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
A6A12_RS01240	COG0471	metal ion transport
A6A12_RS01240	COG0490	domain, Protein
A6A12_RS01250	COG1162	GTPase activity
A6A12_RS01255	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
A6A12_RS01275	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A6A12_RS01280	COG0802	atpase or kinase
A6A12_RS01290	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A6A12_RS01295	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A6A12_RS01305	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A6A12_RS01310	COG0330	HflC and HflK could
A6A12_RS01315	COG0330	HflC and HflK could
A6A12_RS01320	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
A6A12_RS01335	COG0545	Peptidyl-prolyl cis-trans isomerase
A6A12_RS01340	COG2964	Protein conserved in bacteria
A6A12_RS01345	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
A6A12_RS01350	COG2923	Belongs to the DsrF TusC family
A6A12_RS01365	COG0049	tRNA binding
A6A12_RS01370	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A6A12_RS01375	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A6A12_RS01380	COG0360	Binds together with S18 to 16S ribosomal RNA
A6A12_RS01385	COG2965	DNA replication, synthesis of RNA primer
A6A12_RS01395	COG0359	binds to the 23S rRNA
A6A12_RS01410	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A6A12_RS01415	COG0166	Belongs to the GPI family
A6A12_RS01420	COG2433	Pfam Transposase IS66
A6A12_RS01440	COG0735	belongs to the Fur family
A6A12_RS01445	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A6A12_RS01465	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A6A12_RS01475	COG0175	sulfate reduction
A6A12_RS01515	COG0646	methionine synthase
A6A12_RS01515	COG1410	methionine synthase
A6A12_RS01520	COG0527	aspartate kinase activity
A6A12_RS01525	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A6A12_RS01540	COG2239	Acts as a magnesium transporter
A6A12_RS01550	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A6A12_RS01565	COG0629	single-stranded DNA binding
A6A12_RS01570	COG2199	diguanylate cyclase activity
A6A12_RS01570	COG2200	EAL domain
A6A12_RS01595	COG3267	Type II secretory pathway component ExeA
A6A12_RS01595	COG3409	Peptidoglycan-binding domain 1 protein
A6A12_RS01605	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A6A12_RS01610	COG1459	type II secretion system
A6A12_RS01620	COG2165	general secretion pathway protein
A6A12_RS01655	COG1077	Cell shape determining protein MreB Mrl
A6A12_RS01660	COG1792	Involved in formation and maintenance of cell shape
A6A12_RS01665	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
A6A12_RS01670	COG0424	maF-like protein
A6A12_RS01680	COG3164	Protein of unknown function
A6A12_RS01685	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A6A12_RS01690	COG0312	modulator of DNA gyrase
A6A12_RS01695	COG2235	arginine
A6A12_RS01715	COG0589	response to stress
A6A12_RS01725	COG2358	TRAP transporter, solute receptor (TAXI family
A6A12_RS01735	COG1438	arginine binding
A6A12_RS01745	COG0531	amino acid
A6A12_RS01750	COG0142	geranyltranstransferase activity
A6A12_RS01760	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A6A12_RS01765	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A6A12_RS01770	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A6A12_RS01775	COG2966	Psort location CytoplasmicMembrane, score
A6A12_RS01780	COG3610	response to peptide
A6A12_RS01795	COG2967	ApaG domain
A6A12_RS01800	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A6A12_RS01805	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A6A12_RS01810	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6A12_RS01815	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
A6A12_RS01820	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A6A12_RS01870	COG0741	lytic transglycosylase activity
A6A12_RS01875	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
A6A12_RS01890	COG2066	Belongs to the glutaminase family
A6A12_RS01895	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A6A12_RS01900	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A6A12_RS01910	COG1872	DUF167
A6A12_RS01915	COG0762	integral membrane protein
A6A12_RS01920	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A6A12_RS01925	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A6A12_RS01940	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A6A12_RS01945	COG1678	Uncharacterized ACR, COG1678
A6A12_RS01955	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A6A12_RS01960	COG2356	endonuclease I
A6A12_RS01965	COG3091	SprT-like family
A6A12_RS01970	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A6A12_RS01975	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A6A12_RS01980	COG0583	DNA-binding transcription factor activity
A6A12_RS01985	COG4771	TonB-dependent receptor
A6A12_RS01990	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A6A12_RS01995	COG0126	phosphoglycerate kinase activity
A6A12_RS02005	COG0191	fructose-bisphosphate aldolase activity
A6A12_RS02010	COG0668	transmembrane transport
A6A12_RS02030	COG3706	GGDEF domain
A6A12_RS02040	COG1349	DNA-binding transcription factor activity
A6A12_RS02050	COG5492	domain, Protein
A6A12_RS02050	COG4932	domain protein
A6A12_RS02070	COG3501	Rhs element vgr protein
A6A12_RS02075	COG4104	PAAR repeat-containing protein
A6A12_RS02220	COG1484	DNA-dependent DNA replication
A6A12_RS02225	COG4584	PFAM Integrase catalytic
A6A12_RS02295	COG0210	DNA helicase
A6A12_RS02315	COG3550	peptidyl-serine autophosphorylation
A6A12_RS02335	COG0358	DNA primase activity
A6A12_RS02340	COG1610	YqeY-like protein
A6A12_RS02345	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A6A12_RS02350	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A6A12_RS02365	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A6A12_RS02370	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A6A12_RS02375	COG1968	undecaprenyl-diphosphatase activity
A6A12_RS02380	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
A6A12_RS02385	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A6A12_RS02390	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A6A12_RS02395	COG0585	pseudouridine synthase activity
A6A12_RS02400	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
A6A12_RS02405	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A6A12_RS02410	COG4942	peptidase
A6A12_RS02410	COG1388	LysM domain
A6A12_RS02415	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A6A12_RS02420	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A6A12_RS02430	COG4150	thiosulfate binding
A6A12_RS02440	COG4208	sulfate ABC transporter
A6A12_RS02445	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
A6A12_RS02450	COG1546	Belongs to the CinA family
A6A12_RS02455	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A6A12_RS02460	COG2137	regulation of response to DNA damage stimulus
A6A12_RS02465	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A6A12_RS02470	COG0527	aspartate kinase activity
A6A12_RS02475	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
A6A12_RS02505	COG3630	sodium ion export across plasma membrane
A6A12_RS02510	COG5016	pyruvate
A6A12_RS02510	COG0511	ligase activity, forming carbon-carbon bonds
A6A12_RS02515	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
A6A12_RS02525	COG1238	metal cluster binding
A6A12_RS02530	COG0612	Peptidase, M16
A6A12_RS02540	COG1854	S-ribosylhomocysteine lyase activity
A6A12_RS02545	COG4536	flavin adenine dinucleotide binding
A6A12_RS02550	COG4137	Cytochrome C assembly protein
A6A12_RS02555	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A6A12_RS02560	COG0228	four-way junction DNA binding
A6A12_RS02565	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A6A12_RS02570	COG0336	Belongs to the RNA methyltransferase TrmD family
A6A12_RS02575	COG0335	large ribosomal subunit rRNA binding
A6A12_RS02585	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
A6A12_RS02590	COG0237	dephospho-CoA kinase activity
A6A12_RS02600	COG1459	type II secretion system
A6A12_RS02605	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A6A12_RS02615	COG0157	Belongs to the NadC ModD family
A6A12_RS02625	COG0716	FMN binding
A6A12_RS02630	COG4974	Belongs to the 'phage' integrase family
A6A12_RS02635	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A6A12_RS02640	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A6A12_RS02645	COG2186	Transcriptional regulator
A6A12_RS02650	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
A6A12_RS02655	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6A12_RS02660	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6A12_RS02675	COG0288	reversible hydration of carbon dioxide
A6A12_RS02680	COG0659	secondary active sulfate transmembrane transporter activity
A6A12_RS02685	COG1131	(ABC) transporter
A6A12_RS02690	COG0842	Transport permease protein
A6A12_RS02700	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A6A12_RS02710	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A6A12_RS02720	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6A12_RS02725	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A6A12_RS02730	COG1489	DNA binding
A6A12_RS02735	COG1643	Atp-dependent helicase
A6A12_RS02740	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A6A12_RS02745	COG1752	Esterase of the alpha-beta hydrolase superfamily
A6A12_RS02750	COG1049	propionate catabolic process, 2-methylcitrate cycle
A6A12_RS02755	COG1929	Belongs to the glycerate kinase type-1 family
A6A12_RS02760	COG2610	gluconate transmembrane transporter activity
A6A12_RS02765	COG3835	regulator
A6A12_RS02770	COG3112	Uncharacterised protein family (UPF0231)
A6A12_RS02780	COG0004	ammonium transporteR
A6A12_RS02785	COG1840	ABC-type Fe3 transport system, periplasmic component
A6A12_RS02800	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A6A12_RS02815	COG2971	BadF BadG BcrA BcrD
A6A12_RS02825	COG4608	Belongs to the ABC transporter superfamily
A6A12_RS02830	COG0444	Belongs to the ABC transporter superfamily
A6A12_RS02835	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6A12_RS02850	COG2205	protein histidine kinase activity
A6A12_RS02850	COG0784	Response regulator, receiver
A6A12_RS02860	COG0628	permease
A6A12_RS02865	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A6A12_RS02870	COG0316	Belongs to the HesB IscA family
A6A12_RS02885	COG0739	heme binding
A6A12_RS02890	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A6A12_RS02900	COG2239	Acts as a magnesium transporter
A6A12_RS02905	COG2027	D-alanyl-D-alanine carboxypeptidase
A6A12_RS02915	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A6A12_RS02920	COG1534	Rna-binding protein
A6A12_RS02925	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
A6A12_RS02930	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A6A12_RS02935	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A6A12_RS02940	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A6A12_RS02945	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A6A12_RS02960	COG0779	Required for maturation of 30S ribosomal subunits
A6A12_RS02965	COG0195	Participates in both transcription termination and antitermination
A6A12_RS02970	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A6A12_RS02980	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A6A12_RS02985	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A6A12_RS03000	COG1846	Transcriptional regulator
A6A12_RS03010	COG0826	peptidase U32
A6A12_RS03015	COG0826	peptidase U32
A6A12_RS03025	COG3154	lipid carrier protein
A6A12_RS03030	COG3153	acetyltransferase
A6A12_RS03055	COG0513	Belongs to the DEAD box helicase family
A6A12_RS03060	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A6A12_RS03075	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A6A12_RS03080	COG2204	response regulator
A6A12_RS03090	COG0667	Aldo Keto reductase
A6A12_RS03100	COG0494	nUDIX hydrolase
A6A12_RS03110	COG0730	response to heat
A6A12_RS03120	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
A6A12_RS03155	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
A6A12_RS03165	COG1283	sodium-dependent phosphate transmembrane transporter activity
A6A12_RS03170	COG0583	DNA-binding transcription factor activity
A6A12_RS03175	COG0640	Transcriptional regulator
A6A12_RS03180	COG0268	Binds directly to 16S ribosomal RNA
A6A12_RS03185	COG0728	peptidoglycan biosynthetic process
A6A12_RS03190	COG0196	riboflavin kinase activity
A6A12_RS03200	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A6A12_RS03205	COG1047	Peptidyl-prolyl cis-trans
A6A12_RS03210	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A6A12_RS03215	COG1966	Carbon starvation protein
A6A12_RS03230	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
A6A12_RS03235	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
A6A12_RS03245	COG3279	Response regulator of the LytR AlgR family
A6A12_RS03250	COG3275	phosphorelay sensor kinase activity
A6A12_RS03255	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A6A12_RS03260	COG0287	Prephenate dehydrogenase
A6A12_RS03260	COG1605	Chorismate mutase
A6A12_RS03270	COG0488	(ABC) transporter
A6A12_RS03280	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
A6A12_RS03285	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
A6A12_RS03290	COG5001	Diguanylate cyclase
A6A12_RS03295	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A6A12_RS03300	COG0077	Prephenate dehydratase
A6A12_RS03300	COG1605	Chorismate mutase
A6A12_RS03305	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A6A12_RS03310	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A6A12_RS03315	COG0564	pseudouridine synthase activity
A6A12_RS03320	COG1496	oxidoreductase activity
A6A12_RS03325	COG0542	response to heat
A6A12_RS03370	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A6A12_RS03375	COG0826	peptidase U32
A6A12_RS03385	COG0745	RESPONSE REGULATOR receiver
A6A12_RS03390	COG5002	protein histidine kinase activity
A6A12_RS03400	COG0248	Ppx GppA phosphatase
A6A12_RS03405	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A6A12_RS03415	COG0581	inorganic phosphate transmembrane transporter activity
A6A12_RS03420	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A6A12_RS03425	COG0704	Plays a role in the regulation of phosphate uptake
A6A12_RS03435	COG0450	alkyl hydroperoxide reductase
A6A12_RS03440	COG0583	DNA-binding transcription factor activity
A6A12_RS03445	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
A6A12_RS03455	COG0517	IMP dehydrogenase activity
A6A12_RS03465	COG0343	queuine tRNA-ribosyltransferase activity
A6A12_RS03470	COG1862	Preprotein translocase
A6A12_RS03475	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6A12_RS03480	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6A12_RS03485	COG0483	inositol monophosphate 1-phosphatase activity
A6A12_RS03490	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
A6A12_RS03495	COG1959	2 iron, 2 sulfur cluster binding
A6A12_RS03505	COG0822	iron-sulfur transferase activity
A6A12_RS03510	COG0316	Belongs to the HesB IscA family
A6A12_RS03520	COG0443	Heat shock 70 kDa protein
A6A12_RS03525	COG0633	Ferredoxin
A6A12_RS03530	COG2975	iron-sulfur cluster assembly
A6A12_RS03535	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A6A12_RS03550	COG1426	Protein conserved in bacteria
A6A12_RS03555	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A6A12_RS03560	COG0124	histidyl-tRNA synthetase
A6A12_RS03565	COG2976	Protein conserved in bacteria
A6A12_RS03570	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A6A12_RS03575	COG1160	GTP binding
A6A12_RS03590	COG0517	IMP dehydrogenase activity
A6A12_RS03590	COG0516	GMP reductase activity
A6A12_RS03595	COG0519	Catalyzes the synthesis of GMP from XMP
A6A12_RS03595	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A6A12_RS03600	COG0351	phosphomethylpyrimidine kinase
A6A12_RS03610	COG1584	GPR1 FUN34 yaaH family protein
A6A12_RS03615	COG1115	amino acid carrier protein
A6A12_RS03645	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6A12_RS03645	COG3711	transcriptional antiterminator
A6A12_RS03660	COG3964	amidohydrolase
A6A12_RS03805	COG2003	Belongs to the UPF0758 family
A6A12_RS03820	COG1715	Restriction endonuclease
A6A12_RS03825	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
A6A12_RS03845	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
A6A12_RS03850	COG0582	viral genome integration into host DNA
A6A12_RS03865	COG2867	negative regulation of translational initiation
A6A12_RS03870	COG2914	Belongs to the UPF0125 (RnfH) family
A6A12_RS03875	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A6A12_RS03880	COG0497	DNA recombination
A6A12_RS03885	COG3033	Beta-eliminating lyase
A6A12_RS03890	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A6A12_RS03895	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A6A12_RS03905	COG0484	heat shock protein binding
A6A12_RS03935	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
A6A12_RS03940	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
A6A12_RS03950	COG0583	DNA-binding transcription factor activity
A6A12_RS03955	COG0590	tRNA wobble adenosine to inosine editing
A6A12_RS03960	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
A6A12_RS03970	COG0047	phosphoribosylformylglycinamidine synthase activity
A6A12_RS03970	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A6A12_RS03990	COG2979	Protein of unknown function (DUF533)
A6A12_RS03995	COG0442	prolyl-tRNA aminoacylation
A6A12_RS04000	COG1720	tRNA m6t6A37 methyltransferase activity
A6A12_RS04005	COG0254	rRNA binding
A6A12_RS04010	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A6A12_RS04040	COG3098	single-species biofilm formation
A6A12_RS04045	COG0564	pseudouridine synthase activity
A6A12_RS04050	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A6A12_RS04055	COG0142	geranyltranstransferase activity
A6A12_RS04060	COG1722	exodeoxyribonuclease VII activity
A6A12_RS04065	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
A6A12_RS04075	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6A12_RS04075	COG0301	tRNA thio-modification
A6A12_RS04080	COG0583	DNA-binding transcription factor activity
A6A12_RS04085	COG2363	Small membrane protein
A6A12_RS04090	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
A6A12_RS04095	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6A12_RS04100	COG1611	Belongs to the LOG family
A6A12_RS04125	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
A6A12_RS04130	COG1464	Belongs to the NlpA lipoprotein family
A6A12_RS04135	COG2011	ABC-type metal ion transport system permease component
A6A12_RS04140	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A6A12_RS04145	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A6A12_RS04160	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6A12_RS04160	COG1263	PTS System
A6A12_RS04165	COG0366	Alpha amylase catalytic
A6A12_RS04170	COG0745	RESPONSE REGULATOR receiver
A6A12_RS04175	COG2205	protein histidine kinase activity
A6A12_RS04200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6A12_RS04205	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A6A12_RS04210	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A6A12_RS04215	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A6A12_RS04220	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
A6A12_RS04260	COG1045	serine acetyltransferase
A6A12_RS04270	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
A6A12_RS04300	COG0489	protein tyrosine kinase activity
A6A12_RS04305	COG1596	polysaccharide export
A6A12_RS04335	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A6A12_RS04340	COG0321	lipoyl(octanoyl) transferase activity
A6A12_RS04345	COG2921	Belongs to the UPF0250 family
A6A12_RS04350	COG1686	Belongs to the peptidase S11 family
A6A12_RS04355	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A6A12_RS04360	COG0772	Belongs to the SEDS family
A6A12_RS04365	COG0768	penicillin binding
A6A12_RS04370	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A6A12_RS04375	COG0799	negative regulation of ribosome biogenesis
A6A12_RS04380	COG1466	dna polymerase III delta subunit
A6A12_RS04385	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
A6A12_RS04390	COG0495	leucyl-tRNA aminoacylation
A6A12_RS04395	COG2888	peptidyl-tyrosine sulfation
A6A12_RS04400	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A6A12_RS04405	COG4535	Mg2 and Co2 transporter CorC
A6A12_RS04410	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A6A12_RS04415	COG1702	phosphate starvation-inducible protein PhoH
A6A12_RS04420	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A6A12_RS04425	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A6A12_RS04430	COG2190	(PTS) system
A6A12_RS04435	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A6A12_RS04440	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6A12_RS04445	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A6A12_RS04450	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
A6A12_RS04455	COG3115	cell septum assembly
A6A12_RS04460	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A6A12_RS04480	COG0789	Transcriptional regulator
A6A12_RS04490	COG0330	HflC and HflK could
A6A12_RS04495	COG3118	belongs to the thioredoxin family
A6A12_RS04500	COG1090	epimerase
A6A12_RS04505	COG0622	Phosphoesterase
A6A12_RS04520	COG3710	Transcriptional regulator
A6A12_RS04525	COG0326	Molecular chaperone. Has ATPase activity
A6A12_RS04535	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A6A12_RS04540	COG3104	oligopeptide transport
A6A12_RS04550	COG0367	asparagine synthase
A6A12_RS04555	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A6A12_RS04555	COG4651	solute:proton antiporter activity
A6A12_RS04560	COG1846	Transcriptional regulator
A6A12_RS04560	COG1940	carbohydrate kinase activity
A6A12_RS04565	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A6A12_RS04570	COG1263	PTS System
A6A12_RS04570	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6A12_RS04570	COG2190	(PTS) system
A6A12_RS04575	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6A12_RS04585	COG0101	tRNA pseudouridine synthase activity
A6A12_RS04590	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A6A12_RS04595	COG0285	dihydrofolate synthase activity
A6A12_RS04600	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
A6A12_RS04605	COG1286	toxin biosynthetic process
A6A12_RS04610	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A6A12_RS04615	COG2056	Na+-H+ antiporter family
A6A12_RS04620	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A6A12_RS04630	COG0346	lactoylglutathione lyase activity
A6A12_RS04635	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A6A12_RS04640	COG4660	Part of a membrane complex involved in electron transport
A6A12_RS04645	COG4659	FMN binding
A6A12_RS04650	COG4658	electron transport chain
A6A12_RS04655	COG4656	Part of a membrane complex involved in electron transport
A6A12_RS04660	COG2878	Part of a membrane complex involved in electron transport
A6A12_RS04665	COG4657	Part of a membrane complex involved in electron transport
A6A12_RS04675	COG4774	siderophore transport
A6A12_RS04675	COG1629	transport
A6A12_RS04680	COG2382	esterase
A6A12_RS04710	COG3433	isochorismatase activity
A6A12_RS04710	COG1535	isochorismatase
A6A12_RS04715	COG1021	2,3-dihydroxybenzoate-AMP ligase
A6A12_RS04720	COG1169	isochorismate synthase
A6A12_RS04725	COG1028	Short-chain dehydrogenase reductase Sdr
A6A12_RS04730	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A6A12_RS04745	COG0556	nucleotide-excision repair
A6A12_RS04750	COG2204	response regulator
A6A12_RS04755	COG2198	Histidine kinase
A6A12_RS04760	COG0391	Required for morphogenesis under gluconeogenic growth conditions
A6A12_RS04765	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A6A12_RS04770	COG0521	Mo-molybdopterin cofactor biosynthetic process
A6A12_RS04780	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
A6A12_RS04785	COG0314	molybdopterin synthase activity
A6A12_RS04790	COG2199	diguanylate cyclase activity
A6A12_RS04795	COG0517	IMP dehydrogenase activity
A6A12_RS04795	COG0617	tRNA 3'-terminal CCA addition
A6A12_RS04795	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A6A12_RS04805	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
A6A12_RS04815	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6A12_RS04815	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6A12_RS04820	COG0489	protein tyrosine kinase activity
A6A12_RS04825	COG0572	uridine kinase
A6A12_RS04830	COG2982	Protein involved in outer membrane biogenesis
A6A12_RS04835	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
A6A12_RS04840	COG2067	long-chain fatty acid transport protein
A6A12_RS04845	COG2067	long-chain fatty acid transport protein
A6A12_RS04855	COG1595	DNA-templated transcription, initiation
A6A12_RS04870	COG0183	Belongs to the thiolase family
A6A12_RS04875	COG1250	3-hydroxyacyl-CoA dehydrogenase
A6A12_RS04875	COG1024	Enoyl-CoA hydratase
A6A12_RS04880	COG0778	Nitroreductase
A6A12_RS04885	COG0583	DNA-binding transcription factor activity
A6A12_RS04890	COG0745	RESPONSE REGULATOR receiver
A6A12_RS04900	COG2832	Protein of unknown function (DUF454)
A6A12_RS04905	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A6A12_RS04920	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A6A12_RS04930	COG2983	Belongs to the UPF0260 family
A6A12_RS04945	COG2226	methyltransferase
A6A12_RS04960	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6A12_RS04970	COG3139	Protein of unknown function (DUF1315)
A6A12_RS04975	COG0252	asparaginase activity
A6A12_RS04980	COG0616	signal peptide processing
A6A12_RS04985	COG1902	pentaerythritol trinitrate reductase activity
A6A12_RS04985	COG0446	pyridine nucleotide-disulphide oxidoreductase
A6A12_RS04990	COG0788	formyltetrahydrofolate deformylase activity
A6A12_RS05000	COG1199	ATP-dependent helicase activity
A6A12_RS05005	COG1214	PFAM Peptidase M22, glycoprotease
A6A12_RS05020	COG0596	Alpha beta hydrolase
A6A12_RS05025	COG0318	PFAM AMP-dependent synthetase and ligase
A6A12_RS05030	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
A6A12_RS05035	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
A6A12_RS05040	COG2894	cell division
A6A12_RS05050	COG3100	YcgL domain-containing protein
A6A12_RS05055	COG2951	lytic endotransglycosylase activity
A6A12_RS05060	COG0583	DNA-binding transcription factor activity
A6A12_RS05065	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A6A12_RS05090	COG4628	conserved protein (DUF2132)
A6A12_RS05105	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A6A12_RS05115	COG0513	Belongs to the DEAD box helicase family
A6A12_RS05125	COG1760	l-serine dehydratase
A6A12_RS05130	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
A6A12_RS05140	COG2205	protein histidine kinase activity
A6A12_RS05145	COG1653	transport
A6A12_RS05155	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A6A12_RS05160	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
A6A12_RS05165	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A6A12_RS05185	COG0544	peptidyl-prolyl cis-trans isomerase activity
A6A12_RS05195	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A6A12_RS05200	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A6A12_RS05205	COG0776	regulation of translation
A6A12_RS05210	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6A12_RS05215	COG1555	photosystem II stabilization
A6A12_RS05220	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A6A12_RS05225	COG0539	negative regulation of cytoplasmic translation
A6A12_RS05230	COG0776	regulation of translation
A6A12_RS05235	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
A6A12_RS05240	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
A6A12_RS05255	COG0583	DNA-binding transcription factor activity
A6A12_RS05265	COG0686	Belongs to the AlaDH PNT family
A6A12_RS05270	COG1522	sequence-specific DNA binding
A6A12_RS05275	COG1674	ftsk spoiiie
A6A12_RS05285	COG0501	Belongs to the peptidase M48B family
A6A12_RS05295	COG0300	oxidoreductase activity
A6A12_RS05310	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A6A12_RS05320	COG2268	Band 7 protein
A6A12_RS05330	COG1032	radical SAM domain protein
A6A12_RS05340	COG2200	EAL domain
A6A12_RS05340	COG2203	Gaf domain
A6A12_RS05340	COG2199	diguanylate cyclase activity
A6A12_RS05355	COG0583	DNA-binding transcription factor activity
A6A12_RS05360	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A6A12_RS05370	COG2350	Protein conserved in bacteria
A6A12_RS05400	COG0159	tryptophan synthase activity
A6A12_RS05405	COG0133	tryptophan synthase activity
A6A12_RS05410	COG0135	phosphoribosylanthranilate isomerase activity
A6A12_RS05410	COG0134	indole-3-glycerol-phosphate synthase activity
A6A12_RS05415	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A6A12_RS05420	COG0512	Glutamine amidotransferase of anthranilate synthase
A6A12_RS05425	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A6A12_RS05435	COG0613	PHP domain protein
A6A12_RS05440	COG0009	L-threonylcarbamoyladenylate synthase
A6A12_RS05445	COG1187	pseudouridine synthase activity
A6A12_RS05460	COG1595	DNA-templated transcription, initiation
A6A12_RS05475	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A6A12_RS05480	COG4988	ABC transporter
A6A12_RS05485	COG0492	ferredoxin-NADP+ reductase activity
A6A12_RS05505	COG2949	membrane
A6A12_RS05515	COG0281	malic enzyme
A6A12_RS05525	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A6A12_RS05530	COG3273	potassium ion transport
A6A12_RS05530	COG2985	domain, Protein
A6A12_RS05535	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A6A12_RS05545	COG1737	Transcriptional regulator
A6A12_RS05550	COG0076	glutamate decarboxylase activity
A6A12_RS05560	COG2431	L-lysine efflux transmembrane transporter activity
A6A12_RS05570	COG3070	regulator of competence-specific genes
A6A12_RS05585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6A12_RS05585	COG4191	Histidine kinase
A6A12_RS05595	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A6A12_RS05600	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A6A12_RS05605	COG2915	High frequency lysogenization protein hflD homolog
A6A12_RS05610	COG0482	sulfurtransferase activity
A6A12_RS05620	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6A12_RS05625	COG2916	Histone family protein nucleoid-structuring protein H-NS
A6A12_RS05630	COG1757	Na H antiporter
A6A12_RS05635	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A6A12_RS05640	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A6A12_RS05645	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A6A12_RS05650	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A6A12_RS05650	COG0131	Imidazoleglycerol-phosphate dehydratase
A6A12_RS05655	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A6A12_RS05660	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A6A12_RS05665	COG0107	imidazoleglycerol-phosphate synthase activity
A6A12_RS05670	COG0140	phosphoribosyl-ATP diphosphatase activity
A6A12_RS05670	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A6A12_RS05675	COG1187	pseudouridine synthase activity
A6A12_RS05685	COG1278	Cold shock
A6A12_RS05690	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
A6A12_RS05695	COG0542	response to heat
A6A12_RS05700	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A6A12_RS05705	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
A6A12_RS05710	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
A6A12_RS05725	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A6A12_RS05730	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A6A12_RS05735	COG0297	glycogen (starch) synthase activity
A6A12_RS05755	COG3070	regulator of competence-specific genes
A6A12_RS05760	COG1609	Transcriptional regulator
A6A12_RS05770	COG0745	RESPONSE REGULATOR receiver
A6A12_RS05775	COG1434	Gram-negative-bacterium-type cell wall biogenesis
A6A12_RS05780	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A6A12_RS05790	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
A6A12_RS05795	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
A6A12_RS05810	COG4067	protein conserved in archaea
A6A12_RS05810	COG0189	ligase activity
A6A12_RS05815	COG0500	methyltransferase
A6A12_RS05820	COG4106	trans-aconitate 2-methyltransferase activity
A6A12_RS05830	COG1801	Protein of unknown function DUF72
A6A12_RS05835	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A6A12_RS05840	COG1435	thymidine kinase activity
A6A12_RS05845	COG1434	Gram-negative-bacterium-type cell wall biogenesis
A6A12_RS05870	COG2116	formate transmembrane transporter activity
A6A12_RS05875	COG4459	periplasmic nitrate reductase
A6A12_RS05880	COG3005	denitrification pathway
A6A12_RS05885	COG0243	molybdopterin cofactor binding
A6A12_RS05895	COG1227	inorganic diphosphatase activity
A6A12_RS05910	COG4172	Belongs to the ABC transporter superfamily
A6A12_RS05920	COG4171	peptide transport system, permease
A6A12_RS05935	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
A6A12_RS05940	COG1842	Phage shock protein A
A6A12_RS05955	COG0519	Catalyzes the synthesis of GMP from XMP
A6A12_RS05960	COG0626	cystathionine gamma-synthase activity
A6A12_RS05970	COG0733	neurotransmitter:sodium symporter activity
A6A12_RS05975	COG0564	pseudouridine synthase activity
A6A12_RS05990	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A6A12_RS05995	COG4136	ATPase activity
A6A12_RS06000	COG4135	transport system, permease component
A6A12_RS06005	COG4134	Bacterial extracellular solute-binding protein
A6A12_RS06015	COG3313	Fe-S protein
A6A12_RS06045	COG0513	Belongs to the DEAD box helicase family
A6A12_RS06060	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A6A12_RS06065	COG2205	protein histidine kinase activity
A6A12_RS06080	COG1061	Type III restriction enzyme res subunit
A6A12_RS06085	COG1187	pseudouridine synthase activity
A6A12_RS06090	COG2814	Major facilitator Superfamily
A6A12_RS06100	COG0702	epimerase
A6A12_RS06105	COG0534	Mate efflux family protein
A6A12_RS06110	COG4181	ATPase activity
A6A12_RS06125	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A6A12_RS06150	COG0840	transmembrane signaling receptor activity
A6A12_RS06180	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A6A12_RS06185	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A6A12_RS06190	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A6A12_RS06200	COG0840	transmembrane signaling receptor activity
A6A12_RS06220	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
A6A12_RS06235	COG0511	ligase activity, forming carbon-carbon bonds
A6A12_RS06235	COG5016	pyruvate
A6A12_RS06240	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
A6A12_RS06250	COG4565	transcriptional regulatory protein
A6A12_RS06260	COG2301	Belongs to the HpcH HpaI aldolase family
A6A12_RS06265	COG3051	citrate lyase alpha subunit
A6A12_RS06275	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
A6A12_RS06300	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6A12_RS06300	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6A12_RS06300	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6A12_RS06305	COG2207	Transcriptional regulator
A6A12_RS06315	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6A12_RS06325	COG1342	Belongs to the UPF0251 family
A6A12_RS06345	COG1129	ABC transporter
A6A12_RS06360	COG1902	pentaerythritol trinitrate reductase activity
A6A12_RS06365	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A6A12_RS06370	COG5002	protein histidine kinase activity
A6A12_RS06375	COG0745	RESPONSE REGULATOR receiver
A6A12_RS06405	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
A6A12_RS06410	COG0372	Belongs to the citrate synthase family
A6A12_RS06415	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A6A12_RS06420	COG2828	Protein conserved in bacteria
A6A12_RS06440	COG0561	phosphatase activity
A6A12_RS06445	COG0602	queuosine metabolic process
A6A12_RS06490	COG1254	Belongs to the acylphosphatase family
A6A12_RS06495	COG2920	part of a sulfur-relay system
A6A12_RS06500	COG0670	Belongs to the BI1 family
A6A12_RS06505	COG1126	abc transporter atp-binding protein
A6A12_RS06510	COG0765	amino acid transport
A6A12_RS06515	COG4597	amino acid ABC transporter
A6A12_RS06520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6A12_RS06525	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A6A12_RS06525	COG1648	precorrin-2 dehydrogenase activity
A6A12_RS06535	COG1666	GTP binding
A6A12_RS06540	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A6A12_RS06560	COG2996	Protein conserved in bacteria
A6A12_RS06570	COG3008	intermembrane lipid transfer
A6A12_RS06575	COG2995	paraquat-inducible protein a
A6A12_RS06580	COG1132	(ABC) transporter
A6A12_RS06585	COG1956	GAF domain-containing protein
A6A12_RS06590	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
A6A12_RS06605	COG0308	aminopeptidase N
A6A12_RS06615	COG2902	Dehydrogenase
A6A12_RS06620	COG0167	dihydroorotate dehydrogenase activity
A6A12_RS06630	COG0116	Belongs to the methyltransferase superfamily
A6A12_RS06630	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A6A12_RS06640	COG0488	(ABC) transporter
A6A12_RS06655	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A6A12_RS06660	COG1067	ATP-dependent peptidase activity
A6A12_RS06665	COG3120	sequence-specific DNA binding
A6A12_RS06695	COG3278	Belongs to the heme-copper respiratory oxidase family
A6A12_RS06710	COG2010	Cytochrome c
A6A12_RS06720	COG2217	Heavy metal translocating P-type atpase
A6A12_RS06735	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A6A12_RS06740	COG0589	response to stress
A6A12_RS06765	COG3842	ATPase activity
A6A12_RS06770	COG1176	ABC-type spermidine putrescine transport system, permease component I
A6A12_RS06775	COG1177	transmembrane transport
A6A12_RS06780	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A6A12_RS06790	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A6A12_RS06795	COG0004	ammonium transporteR
A6A12_RS06800	COG0488	(ABC) transporter
A6A12_RS06805	COG2197	response regulator
A6A12_RS06815	COG2271	Major facilitator Superfamily
A6A12_RS06820	COG1840	ABC-type Fe3 transport system, periplasmic component
A6A12_RS06830	COG3842	ATPase activity
A6A12_RS06835	COG0746	molybdenum cofactor guanylyltransferase activity
A6A12_RS06840	COG1763	Mo-molybdopterin cofactor biosynthetic process
A6A12_RS06850	COG1940	carbohydrate kinase activity
A6A12_RS06855	COG3148	PFAM DTW domain containing protein
A6A12_RS06865	COG0840	transmembrane signaling receptor activity
A6A12_RS06870	COG0791	NLP P60 protein
A6A12_RS06880	COG3001	Fructosamine kinase
A6A12_RS06895	COG1793	dna ligase
A6A12_RS06900	COG4667	esterase of the alpha-beta hydrolase superfamily
A6A12_RS06915	COG0848	biopolymer transport protein
A6A12_RS06920	COG0811	peptide transport
A6A12_RS06925	COG0811	peptide transport
A6A12_RS06955	COG0625	glutathione transferase activity
A6A12_RS06965	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
A6A12_RS06975	COG2195	Cleaves the N-terminal amino acid of tripeptides
A6A12_RS06990	COG1115	amino acid carrier protein
A6A12_RS06995	COG1280	lysine exporter protein (LysE YggA)
A6A12_RS07000	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
A6A12_RS07010	COG2433	Pfam Transposase IS66
A6A12_RS07030	COG1204	response to ionizing radiation
A6A12_RS07070	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
A6A12_RS07075	COG0673	inositol 2-dehydrogenase activity
A6A12_RS07100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6A12_RS07105	COG3962	Belongs to the TPP enzyme family
A6A12_RS07110	COG3718	enzyme involved in inositol metabolism
A6A12_RS07120	COG2176	DNA-directed DNA polymerase activity
A6A12_RS07125	COG0517	IMP dehydrogenase activity
A6A12_RS07125	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A6A12_RS07130	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6A12_RS07135	COG0673	inositol 2-dehydrogenase activity
A6A12_RS07155	COG0477	Major facilitator Superfamily
A6A12_RS07160	COG0583	DNA-binding transcription factor activity
A6A12_RS07170	COG1643	Atp-dependent helicase
A6A12_RS07240	COG1609	Transcriptional regulator
A6A12_RS07245	COG2723	6-phospho-beta-galactosidase activity
A6A12_RS07250	COG0513	Belongs to the DEAD box helicase family
A6A12_RS07255	COG0243	molybdopterin cofactor binding
A6A12_RS07260	COG3005	denitrification pathway
A6A12_RS07265	COG1278	Cold shock
A6A12_RS07280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6A12_RS07280	COG4191	Histidine kinase
A6A12_RS07285	COG0471	metal ion transport
A6A12_RS07295	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A6A12_RS07315	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A6A12_RS07325	COG3768	UPF0283 membrane protein
A6A12_RS07330	COG3106	COG3106 Predicted ATPase
A6A12_RS07345	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A6A12_RS07350	COG0494	nUDIX hydrolase
A6A12_RS07355	COG0814	amino acid
A6A12_RS07360	COG1760	l-serine dehydratase
A6A12_RS07370	COG2356	endonuclease I
A6A12_RS07375	COG0720	synthase
A6A12_RS07380	COG0840	transmembrane signaling receptor activity
A6A12_RS07385	COG0017	Asparaginyl-tRNA synthetase
A6A12_RS07395	COG2201	protein-glutamate methylesterase activity
A6A12_RS07400	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
A6A12_RS07405	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A6A12_RS07410	COG0835	chemotaxis
A6A12_RS07420	COG0643	Histidine kinase
A6A12_RS07420	COG2198	Histidine kinase
A6A12_RS07430	COG0745	RESPONSE REGULATOR receiver
A6A12_RS07435	COG0840	transmembrane signaling receptor activity
A6A12_RS07440	COG2770	Histidine kinase
A6A12_RS07440	COG3437	response regulator, receiver
A6A12_RS07445	COG1448	Aminotransferase
A6A12_RS07450	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
A6A12_RS07465	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A6A12_RS07470	COG1846	Transcriptional regulator
A6A12_RS07485	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6A12_RS07490	COG3108	Peptidase M15
A6A12_RS07495	COG2989	Protein conserved in bacteria
A6A12_RS07525	COG1940	carbohydrate kinase activity
A6A12_RS07530	COG4771	TonB-dependent receptor
A6A12_RS07530	COG1629	transport
A6A12_RS07535	COG0748	coenzyme F420 binding
A6A12_RS07540	COG3721	Heme iron utilization protein
A6A12_RS07545	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
A6A12_RS07550	COG0811	peptide transport
A6A12_RS07555	COG0848	biopolymer transport protein
A6A12_RS07565	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6A12_RS07570	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
A6A12_RS07575	COG1054	Belongs to the UPF0176 family
A6A12_RS07585	COG0840	transmembrane signaling receptor activity
A6A12_RS07590	COG1621	beta-fructofuranosidase activity
A6A12_RS07600	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6A12_RS07600	COG1263	PTS System
A6A12_RS07605	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6A12_RS07610	COG2200	EAL domain
A6A12_RS07615	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A6A12_RS07620	COG0840	transmembrane signaling receptor activity
A6A12_RS07645	COG3220	belongs to the UPF0276 family
A6A12_RS07665	COG1294	oxidase, subunit
A6A12_RS07675	COG0251	oxidation-reduction process
A6A12_RS07695	COG2433	Pfam Transposase IS66
A6A12_RS07745	COG4991	sh3 domain protein
A6A12_RS07745	COG3064	Membrane
A6A12_RS07745	COG0515	serine threonine protein kinase
A6A12_RS07770	COG1716	ATPase activity
A6A12_RS07790	COG1181	Belongs to the D-alanine--D-alanine ligase family
A6A12_RS07865	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
A6A12_RS07905	COG0835	chemotaxis
A6A12_RS07905	COG0784	Response regulator, receiver
A6A12_RS07915	COG4565	transcriptional regulatory protein
A6A12_RS07920	COG3290	protein histidine kinase activity
A6A12_RS07935	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6A12_RS07960	COG3063	Type IV pilus biogenesis stability protein PilW
A6A12_RS07975	COG1451	nucleotide metabolic process
A6A12_RS07985	COG0583	DNA-binding transcription factor activity
A6A12_RS08005	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
A6A12_RS08010	COG4139	cobalamin transport
A6A12_RS08015	COG2988	succinylglutamate desuccinylase activity
A6A12_RS08030	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
A6A12_RS08035	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
A6A12_RS08040	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
A6A12_RS08040	COG1073	alpha beta
A6A12_RS08040	COG3064	Membrane
A6A12_RS08045	COG2994	toxin metabolic process
A6A12_RS08075	COG0702	epimerase
A6A12_RS08080	COG1823	symporter activity
A6A12_RS08085	COG2925	Exonuclease
A6A12_RS08090	COG1380	Effector of murein hydrolase LrgA
A6A12_RS08095	COG1346	cytolysis
A6A12_RS08105	COG5001	Diguanylate cyclase
A6A12_RS08120	COG0500	methyltransferase
A6A12_RS08130	COG0776	regulation of translation
A6A12_RS08135	COG0072	phenylalanine-tRNA ligase activity
A6A12_RS08135	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6A12_RS08140	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A6A12_RS08180	COG0322	excinuclease ABC activity
A6A12_RS08185	COG2197	response regulator
A6A12_RS08190	COG0417	DNA replication proofreading
A6A12_RS08200	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A6A12_RS08205	COG3099	Belongs to the UPF0263 family
A6A12_RS08210	COG3097	Belongs to the UPF0267 family
A6A12_RS08220	COG1228	amidohydrolase
A6A12_RS08225	COG0010	Belongs to the arginase family
A6A12_RS08235	COG2986	histidine ammonia-lyase
A6A12_RS08250	COG0247	lactate metabolic process
A6A12_RS08250	COG0277	FAD linked oxidase domain protein
A6A12_RS08280	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A6A12_RS08285	COG1960	acyl-CoA dehydrogenase activity
A6A12_RS08310	COG5001	Diguanylate cyclase
A6A12_RS08310	COG3300	MHYT domain
A6A12_RS08440	COG0740	serine-type endopeptidase activity
A6A12_RS08455	COG1802	Transcriptional regulator
A6A12_RS08455	COG4626	Terminase
A6A12_RS08520	COG1403	HNH endonuclease
A6A12_RS08610	COG3081	Nucleoid-associated protein
A6A12_RS08640	COG2404	hydrolase activity, acting on ester bonds
A6A12_RS08735	COG0582	viral genome integration into host DNA
A6A12_RS08750	COG0784	Response regulator, receiver
A6A12_RS08750	COG5002	protein histidine kinase activity
A6A12_RS08770	COG2433	Pfam Transposase IS66
A6A12_RS08775	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A6A12_RS08780	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
A6A12_RS08785	COG2885	chlorophyll binding
A6A12_RS08790	COG0823	Involved in the tonB-independent uptake of proteins
A6A12_RS08805	COG0811	peptide transport
A6A12_RS08810	COG0824	Thioesterase
A6A12_RS08815	COG3790	cyd operon protein YbgE
A6A12_RS08820	COG4890	Cyd operon protein YbgT
A6A12_RS08825	COG1294	oxidase, subunit
A6A12_RS08830	COG1271	oxidase subunit
A6A12_RS08835	COG2255	four-way junction helicase activity
A6A12_RS08840	COG0632	four-way junction helicase activity
A6A12_RS08845	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
A6A12_RS08850	COG0215	cysteine-tRNA ligase activity
A6A12_RS08855	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A6A12_RS08860	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A6A12_RS08865	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
A6A12_RS08870	COG3012	SEC-C Motif Domain Protein
A6A12_RS08880	COG1199	ATP-dependent helicase activity
A6A12_RS08890	COG3923	Primosomal replication protein n
A6A12_RS08900	COG0840	transmembrane signaling receptor activity
A6A12_RS08905	COG0708	Exodeoxyribonuclease III
A6A12_RS08910	COG4160	amino acid transport
A6A12_RS08940	COG1882	Formate acetyltransferase
A6A12_RS08955	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A6A12_RS08965	COG3013	Belongs to the UPF0304 family
A6A12_RS08970	COG2766	serine protein kinase
A6A12_RS08975	COG2718	Belongs to the UPF0229 family
A6A12_RS08980	COG2719	SpoVR family
A6A12_RS08990	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
A6A12_RS09005	COG1132	(ABC) transporter
A6A12_RS09010	COG2333	competence protein COMEC
A6A12_RS09010	COG0658	competence protein
A6A12_RS09020	COG4591	ABC-type transport system involved in lipoprotein release permease component
A6A12_RS09025	COG1136	(ABC) transporter
A6A12_RS09030	COG4591	ABC-type transport system involved in lipoprotein release permease component
A6A12_RS09040	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A6A12_RS09055	COG1252	NADH dehydrogenase
A6A12_RS09060	COG3150	esterase
A6A12_RS09085	COG0537	adenosine 5'-monophosphoramidase activity
A6A12_RS09100	COG2186	Transcriptional regulator
A6A12_RS09105	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A6A12_RS09115	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A6A12_RS09120	COG2226	methyltransferase
A6A12_RS09125	COG0156	8-amino-7-oxononanoate synthase activity
A6A12_RS09130	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A6A12_RS09135	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A6A12_RS09145	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A6A12_RS09150	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
A6A12_RS09155	COG0653	protein targeting
A6A12_RS09160	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A6A12_RS09170	COG4120	Belongs to the binding-protein-dependent transport system permease family
A6A12_RS09180	COG3092	negative regulation of chromosome organization
A6A12_RS09185	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A6A12_RS09190	COG0857	belongs to the CobB CobQ family
A6A12_RS09190	COG0280	phosphate acetyltransferase
A6A12_RS09195	COG0435	Glutathione S-transferase
A6A12_RS09205	COG0444	Belongs to the ABC transporter superfamily
A6A12_RS09210	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6A12_RS09215	COG0601	transmembrane transport
A6A12_RS09230	COG0784	Response regulator, receiver
A6A12_RS09230	COG5002	protein histidine kinase activity
A6A12_RS09265	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A6A12_RS09270	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A6A12_RS09290	COG1216	Glycosyl transferase, family 2
A6A12_RS09320	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A6A12_RS09325	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A6A12_RS09330	COG1028	Short-chain dehydrogenase reductase Sdr
A6A12_RS09355	COG0800	Aldolase
A6A12_RS09360	COG2610	gluconate transmembrane transporter activity
A6A12_RS09365	COG3265	gluconokinase activity
A6A12_RS09370	COG0129	dihydroxy-acid dehydratase activity
A6A12_RS09375	COG1609	Transcriptional regulator
A6A12_RS09390	COG5002	protein histidine kinase activity
A6A12_RS09390	COG3850	Histidine kinase
A6A12_RS09400	COG2985	domain, Protein
A6A12_RS09415	COG2194	sulfuric ester hydrolase activity
A6A12_RS09420	COG0642	Histidine kinase
A6A12_RS09425	COG0745	RESPONSE REGULATOR receiver
A6A12_RS09435	COG4221	oxidoreductase activity
A6A12_RS09445	COG1022	Amp-dependent synthetase and ligase
A6A12_RS09470	COG3706	GGDEF domain
A6A12_RS09485	COG3126	Type III secretion system lipoprotein chaperone (YscW)
A6A12_RS09490	COG1946	Acyl-CoA thioesterase
A6A12_RS09495	COG1522	sequence-specific DNA binding
A6A12_RS09545	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
A6A12_RS09555	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
A6A12_RS09560	COG1169	isochorismate synthase
A6A12_RS09570	COG0436	Aminotransferase
A6A12_RS09575	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
A6A12_RS09580	COG0232	Belongs to the dGTPase family. Type 2 subfamily
A6A12_RS09595	COG0616	signal peptide processing
A6A12_RS09600	COG1028	Short-chain dehydrogenase reductase Sdr
A6A12_RS09605	COG0784	Response regulator, receiver
A6A12_RS09605	COG0835	chemotaxis
A6A12_RS09610	COG1940	carbohydrate kinase activity
A6A12_RS09620	COG4667	esterase of the alpha-beta hydrolase superfamily
A6A12_RS09635	COG0733	neurotransmitter:sodium symporter activity
A6A12_RS09645	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6A12_RS09645	COG1263	PTS System
A6A12_RS09650	COG0084	hydrolase, TatD family'
A6A12_RS09655	COG0470	DNA polymerase III
A6A12_RS09660	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A6A12_RS09665	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A6A12_RS09670	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A6A12_RS09695	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A6A12_RS09710	COG1399	metal-binding, possibly nucleic acid-binding protein
A6A12_RS09715	COG0424	maF-like protein
A6A12_RS09720	COG0564	pseudouridine synthase activity
A6A12_RS09725	COG1530	ribonuclease E activity
A6A12_RS09735	COG1012	belongs to the aldehyde dehydrogenase family
A6A12_RS09735	COG1454	alcohol dehydrogenase
A6A12_RS09740	COG2095	MarC family integral membrane protein
A6A12_RS09745	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A6A12_RS09750	COG1757	Na H antiporter
A6A12_RS09765	COG3082	Protein of unknown function (DUF1414)
A6A12_RS09770	COG3083	sulfuric ester hydrolase activity
A6A12_RS09780	COG0243	molybdopterin cofactor binding
A6A12_RS09785	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A6A12_RS09800	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A6A12_RS09805	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
A6A12_RS09825	COG2853	Lipoprotein
A6A12_RS09840	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6A12_RS09845	COG1138	Cytochrome C-type biogenesis protein
A6A12_RS09850	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
A6A12_RS09860	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A6A12_RS09865	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A6A12_RS09870	COG4133	protoheme IX ABC transporter activity
A6A12_RS09880	COG0835	chemotaxis
A6A12_RS09890	COG1192	Involved in chromosome partitioning
A6A12_RS09895	COG2201	protein-glutamate methylesterase activity
A6A12_RS09900	COG0643	Histidine kinase
A6A12_RS09900	COG0784	Response regulator, receiver
A6A12_RS09900	COG2198	Histidine kinase
A6A12_RS09905	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
A6A12_RS09930	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A6A12_RS09935	COG2062	phosphohistidine phosphatase, SixA
A6A12_RS09940	COG1025	Belongs to the peptidase M16 family
A6A12_RS09945	COG3102	Protein conserved in bacteria
A6A12_RS09970	COG1918	ferrous iron import across plasma membrane
A6A12_RS09975	COG4977	sequence-specific DNA binding
A6A12_RS09980	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
A6A12_RS09985	COG1121	(ABC) transporter
A6A12_RS09990	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A6A12_RS10005	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6A12_RS10010	COG0567	Dehydrogenase, E1 component
A6A12_RS10025	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
A6A12_RS10040	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A6A12_RS10050	COG0033	Phosphoglucomutase
A6A12_RS10055	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
A6A12_RS10060	COG0596	Alpha beta hydrolase
A6A12_RS10075	COG1346	cytolysis
A6A12_RS10085	COG0583	DNA-binding transcription factor activity
A6A12_RS10095	COG0735	belongs to the Fur family
A6A12_RS10100	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A6A12_RS10105	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A6A12_RS10110	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A6A12_RS10115	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
A6A12_RS10115	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6A12_RS10120	COG0431	NADPH-dependent FMN reductase
A6A12_RS10130	COG3101	peptidyl-lysine hydroxylation
A6A12_RS10135	COG2860	membrane
A6A12_RS10145	COG2890	protein-(glutamine-N5) methyltransferase activity
A6A12_RS10150	COG2840	Smr protein MutS2
A6A12_RS10160	COG1684	flagellar biosynthetic protein fliR
A6A12_RS10165	COG1987	bacterial-type flagellum assembly
A6A12_RS10215	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A6A12_RS10225	COG1677	Flagellar hook-basal body complex protein FliE
A6A12_RS10245	COG1516	flagellar protein fliS
A6A12_RS10255	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
A6A12_RS10280	COG2837	iron assimilation
A6A12_RS10305	COG1393	Belongs to the ArsC family
A6A12_RS10325	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
A6A12_RS10365	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A6A12_RS10375	COG2801	Transposase and inactivated derivatives
A6A12_RS10410	COG0210	DNA helicase
A6A12_RS10440	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A6A12_RS10460	COG4783	chaperone-mediated protein folding
A6A12_RS10465	COG1393	Belongs to the ArsC family
A6A12_RS10485	COG2233	PERMEase
A6A12_RS10490	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A6A12_RS10500	COG2877	3-deoxy-8-phosphooctulonate synthase activity
A6A12_RS10505	COG2912	Transglutaminase-like superfamily
A6A12_RS10510	COG3094	Invasion gene expression up-regulator, SirB
A6A12_RS10515	COG2890	protein-(glutamine-N5) methyltransferase activity
A6A12_RS10520	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A6A12_RS10525	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A6A12_RS10530	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
A6A12_RS10540	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A6A12_RS10545	COG0193	aminoacyl-tRNA hydrolase activity
A6A12_RS10600	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A6A12_RS10610	COG1705	Flagellar rod assembly protein muramidase FlgJ
A6A12_RS10610	COG3951	Flagellar rod assembly protein muramidase FlgJ
A6A12_RS10615	COG1706	bacterial-type flagellum-dependent cell motility
A6A12_RS10620	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
A6A12_RS10630	COG4787	bacterial-type flagellum-dependent cell motility
A6A12_RS10635	COG1749	Flagellar hook protein flgE
A6A12_RS10650	COG1815	bacterial-type flagellum-dependent cell motility
A6A12_RS10660	COG0835	chemotaxis
A6A12_RS10660	COG0784	Response regulator, receiver
A6A12_RS10670	COG2747	anti-sigma28 factor FlgM
A6A12_RS10715	COG2217	Heavy metal translocating P-type atpase
A6A12_RS10715	COG2608	mercury ion transmembrane transporter activity
A6A12_RS10740	COG1187	pseudouridine synthase activity
A6A12_RS10745	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A6A12_RS10750	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A6A12_RS10755	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A6A12_RS10760	COG0121	glutamine amidotransferase
A6A12_RS10765	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A6A12_RS10785	COG0328	RNA-DNA hybrid ribonuclease activity
A6A12_RS10790	COG2226	methyltransferase
A6A12_RS10795	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6A12_RS10800	COG0741	lytic transglycosylase activity
A6A12_RS10800	COG1388	LysM domain
A6A12_RS10810	COG3021	interspecies interaction between organisms
A6A12_RS10815	COG0347	Belongs to the P(II) protein family
A6A12_RS10825	COG0037	tRNA processing
A6A12_RS10830	COG0825	malonyl-CoA metabolic process
A6A12_RS10835	COG0587	DNA-directed DNA polymerase activity
A6A12_RS10845	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A6A12_RS10855	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A6A12_RS10860	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A6A12_RS10865	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
A6A12_RS10875	COG0750	zinc metalloprotease
A6A12_RS10880	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A6A12_RS10885	COG0575	Belongs to the CDS family
A6A12_RS10890	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A6A12_RS10895	COG0233	cytoplasmic translational termination
A6A12_RS10905	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A6A12_RS10910	COG0052	Belongs to the universal ribosomal protein uS2 family
A6A12_RS10915	COG0024	Methionine aminopeptidase
A6A12_RS10920	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
A6A12_RS10930	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A6A12_RS10935	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A6A12_RS10940	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A6A12_RS10960	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A6A12_RS10960	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A6A12_RS10965	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A6A12_RS10970	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A6A12_RS10975	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A6A12_RS10985	COG1073	alpha beta
A6A12_RS10990	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
A6A12_RS10995	COG2252	PERMEase
A6A12_RS11000	COG2195	Cleaves the N-terminal amino acid of tripeptides
A6A12_RS11005	COG4067	protein conserved in archaea
A6A12_RS11005	COG0189	ligase activity
A6A12_RS11010	COG0189	ligase activity
A6A12_RS11020	COG0733	neurotransmitter:sodium symporter activity
A6A12_RS11035	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A6A12_RS11045	COG1477	protein flavinylation
A6A12_RS11080	COG0271	Belongs to the BolA IbaG family
A6A12_RS11100	COG2211	Major facilitator Superfamily
A6A12_RS11110	COG1595	DNA-templated transcription, initiation
A6A12_RS11125	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A6A12_RS11135	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A6A12_RS11140	COG2166	iron-sulfur cluster assembly
A6A12_RS11145	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A6A12_RS11150	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
A6A12_RS11160	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
A6A12_RS11160	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A6A12_RS11170	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A6A12_RS11175	COG1074	ATP-dependent DNA helicase activity
A6A12_RS11180	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
A6A12_RS11195	COG3141	response to X-ray
A6A12_RS11200	COG2171	N-acyltransferase activity
A6A12_RS11230	COG1609	Transcriptional regulator
A6A12_RS11240	COG1085	galactose-1-phosphate uridylyltransferase
A6A12_RS11245	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A6A12_RS11260	COG0784	Response regulator, receiver
A6A12_RS11260	COG3437	response regulator, receiver
A6A12_RS11265	COG1022	Amp-dependent synthetase and ligase
A6A12_RS11270	COG4628	conserved protein (DUF2132)
A6A12_RS11275	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A6A12_RS11280	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A6A12_RS11290	COG0560	Phosphoserine phosphatase
A6A12_RS11300	COG0813	purine-nucleoside phosphorylase activity
A6A12_RS11305	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
A6A12_RS11310	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
A6A12_RS11315	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
A6A12_RS11320	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A6A12_RS11325	COG0084	hydrolase, TatD family'
A6A12_RS11330	COG3022	response to hydroperoxide
A6A12_RS11335	COG1115	amino acid carrier protein
A6A12_RS11350	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A6A12_RS11355	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
A6A12_RS11360	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
A6A12_RS11365	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A6A12_RS11370	COG0083	homoserine kinase activity
A6A12_RS11385	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A6A12_RS11390	COG0745	RESPONSE REGULATOR receiver
A6A12_RS11400	COG5002	protein histidine kinase activity
A6A12_RS11400	COG2198	Histidine kinase
A6A12_RS11400	COG0784	Response regulator, receiver
A6A12_RS11405	COG1242	4 iron, 4 sulfur cluster binding
A6A12_RS11410	COG0069	glutamate synthase activity
A6A12_RS11410	COG0070	glutamate synthase
A6A12_RS11410	COG0067	glutamate synthase
A6A12_RS11420	COG0067	glutamate synthase
A6A12_RS11420	COG0069	glutamate synthase activity
A6A12_RS11420	COG0070	glutamate synthase
A6A12_RS11425	COG0493	'glutamate synthase
A6A12_RS11440	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A6A12_RS11450	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A6A12_RS11455	COG2860	membrane
A6A12_RS11460	COG0583	DNA-binding transcription factor activity
A6A12_RS11465	COG0730	response to heat
A6A12_RS11470	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A6A12_RS11475	COG0505	Belongs to the CarA family
A6A12_RS11480	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A6A12_RS11485	COG0494	nUDIX hydrolase
A6A12_RS11490	COG0653	protein targeting
A6A12_RS11500	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
A6A12_RS11505	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A6A12_RS11510	COG0849	cell division
A6A12_RS11515	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A6A12_RS11520	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A6A12_RS11525	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A6A12_RS11530	COG0772	Belongs to the SEDS family
A6A12_RS11535	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A6A12_RS11545	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A6A12_RS11550	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A6A12_RS11555	COG0768	penicillin binding
A6A12_RS11560	COG3116	cell division
A6A12_RS11565	COG0275	rRNA processing
A6A12_RS11575	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A6A12_RS11580	COG3107	peptidoglycan biosynthetic process
A6A12_RS11585	COG0792	nuclease activity
A6A12_RS11590	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A6A12_RS11600	COG2969	positive regulation of protein catabolic process
A6A12_RS11605	COG0625	glutathione transferase activity
A6A12_RS11610	COG2857	Cytochrome c1
A6A12_RS11615	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A6A12_RS11620	COG0723	plastoquinol--plastocyanin reductase activity
A6A12_RS11630	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A6A12_RS11640	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
A6A12_RS11645	COG3105	Protein conserved in bacteria
A6A12_RS11650	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A6A12_RS11655	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A6A12_RS11660	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A6A12_RS11665	COG0187	DNA topoisomerase II activity
A6A12_RS11670	COG3150	esterase
A6A12_RS11680	COG3151	Protein conserved in bacteria
A6A12_RS11685	COG0494	nUDIX hydrolase
A6A12_RS11690	COG1538	Outer membrane efflux protein
A6A12_RS11700	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
A6A12_RS11715	COG3025	triphosphatase activity
A6A12_RS11720	COG1392	Phosphate transport regulator
A6A12_RS11725	COG0306	phosphate transporter
A6A12_RS11730	COG4991	sh3 domain protein
A6A12_RS11740	COG3409	Peptidoglycan-binding domain 1 protein
A6A12_RS11740	COG3267	Type II secretory pathway component ExeA
A6A12_RS11745	COG0617	tRNA 3'-terminal CCA addition
A6A12_RS11755	COG0504	CTP synthase activity
A6A12_RS11760	COG3956	TIGRFAM MazG family protein
A6A12_RS11765	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A6A12_RS11770	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A6A12_RS11775	COG4999	Histidine kinase
A6A12_RS11775	COG3850	Histidine kinase
A6A12_RS11775	COG3437	response regulator, receiver
A6A12_RS11775	COG2205	protein histidine kinase activity
A6A12_RS11780	COG0736	holo-[acyl-carrier-protein] synthase activity
A6A12_RS11785	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
A6A12_RS11790	COG1381	Involved in DNA repair and RecF pathway recombination
A6A12_RS11795	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A6A12_RS11800	COG0571	ribonuclease III activity
A6A12_RS11810	COG0481	GTPase activity
A6A12_RS11815	COG3086	response to oxidative stress
A6A12_RS11830	COG1595	DNA-templated transcription, initiation
A6A12_RS11835	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A6A12_RS11845	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
A6A12_RS11865	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A6A12_RS11870	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A6A12_RS11875	COG3079	Belongs to the UPF0149 family
A6A12_RS11880	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
A6A12_RS11890	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A6A12_RS11900	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A6A12_RS11910	COG0028	Belongs to the TPP enzyme family
A6A12_RS11915	COG1022	Amp-dependent synthetase and ligase
A6A12_RS11920	COG0583	DNA-binding transcription factor activity
A6A12_RS11940	COG0473	3-isopropylmalate dehydrogenase activity
A6A12_RS11950	COG0066	3-isopropylmalate dehydratase activity
A6A12_RS12005	COG0795	lipopolysaccharide-transporting ATPase activity
A6A12_RS12010	COG0795	lipopolysaccharide-transporting ATPase activity
A6A12_RS12015	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A6A12_RS12020	COG2927	DNA polymerase III (CHI subunit)
A6A12_RS12025	COG0525	valine-tRNA ligase activity
A6A12_RS12030	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A6A12_RS12035	COG0564	pseudouridine synthase activity
A6A12_RS12045	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A6A12_RS12055	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
A6A12_RS12070	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
A6A12_RS12075	COG0251	oxidation-reduction process
A6A12_RS12090	COG0204	Acyl-transferase
A6A12_RS12095	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A6A12_RS12100	COG5007	Belongs to the BolA IbaG family
A6A12_RS12110	COG2854	intermembrane phospholipid transfer
A6A12_RS12115	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A6A12_RS12120	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A6A12_RS12125	COG1127	ABC transporter
A6A12_RS12135	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A6A12_RS12135	COG0517	IMP dehydrogenase activity
A6A12_RS12140	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
A6A12_RS12150	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
A6A12_RS12155	COG1137	ATPase activity
A6A12_RS12165	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A6A12_RS12170	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6A12_RS12175	COG1660	Displays ATPase and GTPase activities
A6A12_RS12180	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6A12_RS12185	COG2239	Acts as a magnesium transporter
A6A12_RS12190	COG0312	modulator of DNA gyrase
A6A12_RS12195	COG3028	Belongs to the UPF0307 family
A6A12_RS12200	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
A6A12_RS12205	COG1178	ABC-type Fe3 transport system permease component
A6A12_RS12215	COG0163	prenyltransferase activity
A6A12_RS12220	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A6A12_RS12225	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
A6A12_RS12230	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A6A12_RS12240	COG2105	PFAM AIG2 family protein
A6A12_RS12245	COG2911	Protein conserved in bacteria
A6A12_RS12250	COG0729	surface antigen
A6A12_RS12255	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6A12_RS12260	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
A6A12_RS12295	COG0529	Catalyzes the synthesis of activated sulfate
A6A12_RS12300	COG2895	sulfate adenylyltransferase (ATP) activity
A6A12_RS12305	COG0175	sulfate reduction
A6A12_RS12310	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A6A12_RS12310	COG1648	precorrin-2 dehydrogenase activity
A6A12_RS12315	COG0737	Belongs to the 5'-nucleotidase family
A6A12_RS12355	COG0513	Belongs to the DEAD box helicase family
A6A12_RS12360	COG2153	protein acetylation
A6A12_RS12365	COG3266	domain, Protein
A6A12_RS12365	COG3061	Opacity-associated protein A
A6A12_RS12370	COG0545	Peptidyl-prolyl cis-trans isomerase
A6A12_RS12375	COG0203	ribosomal protein L17
A6A12_RS12380	COG0202	RNA polymerase activity
A6A12_RS12385	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A6A12_RS12390	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A6A12_RS12395	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A6A12_RS12400	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A6A12_RS12405	COG0201	protein transport
A6A12_RS12410	COG0200	Binds to the 23S rRNA
A6A12_RS12415	COG1841	ribosomal large subunit assembly
A6A12_RS12420	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A6A12_RS12430	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A6A12_RS12435	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A6A12_RS12440	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A6A12_RS12445	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A6A12_RS12450	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A6A12_RS12460	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A6A12_RS12470	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A6A12_RS12485	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A6A12_RS12490	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A6A12_RS12500	COG0088	Forms part of the polypeptide exit tunnel
A6A12_RS12505	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A6A12_RS12510	COG0051	transcription antitermination factor activity, RNA binding
A6A12_RS12515	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A6A12_RS12520	COG0557	exoribonuclease II activity
A6A12_RS12525	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
A6A12_RS12535	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A6A12_RS12545	COG1047	Peptidyl-prolyl cis-trans
A6A12_RS12550	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
A6A12_RS12560	COG2249	NAD(P)H dehydrogenase (quinone) activity
A6A12_RS12565	COG0488	(ABC) transporter
A6A12_RS12575	COG0429	hydrolase of the alpha beta-hydrolase fold
A6A12_RS12585	COG3954	Phosphoribulokinase
A6A12_RS12590	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A6A12_RS12600	COG1012	belongs to the aldehyde dehydrogenase family
A6A12_RS12610	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A6A12_RS12625	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A6A12_RS12635	COG0583	DNA-binding transcription factor activity
A6A12_RS12650	COG0180	Tryptophanyl-tRNA synthetase
A6A12_RS12655	COG0546	phosphoglycolate phosphatase activity
A6A12_RS12660	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A6A12_RS12665	COG0338	D12 class N6 adenine-specific DNA methyltransferase
A6A12_RS12675	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A6A12_RS12680	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A6A12_RS12710	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A6A12_RS12720	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A6A12_RS12720	COG0678	peroxiredoxin activity
A6A12_RS12725	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6A12_RS12735	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
A6A12_RS12735	COG0165	Argininosuccinate lyase
A6A12_RS12740	COG0137	argininosuccinate synthase activity
A6A12_RS12745	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A6A12_RS12750	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A6A12_RS12755	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A6A12_RS12760	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
A6A12_RS12770	COG1045	serine acetyltransferase
A6A12_RS12775	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A6A12_RS12785	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6A12_RS12790	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
A6A12_RS12795	COG1053	succinate dehydrogenase
A6A12_RS12800	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A6A12_RS12805	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
A6A12_RS12815	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A6A12_RS12820	COG1509	lysine 2,3-aminomutase activity
A6A12_RS12835	COG0459	protein refolding
A6A12_RS12840	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A6A12_RS12870	COG0534	Mate efflux family protein
A6A12_RS12875	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A6A12_RS12880	COG1575	Belongs to the MenA family. Type 1 subfamily
A6A12_RS12885	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
A6A12_RS12890	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A6A12_RS12900	COG1609	Transcriptional regulator
A6A12_RS12905	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A6A12_RS12915	COG0281	malic enzyme
A6A12_RS12925	COG0626	cystathionine gamma-synthase activity
A6A12_RS12930	COG0460	homoserine dehydrogenase
A6A12_RS12930	COG0527	aspartate kinase activity
A6A12_RS12940	COG3074	FtsZ-dependent cytokinesis
A6A12_RS12945	COG1494	fructose-1,6-bisphosphatase
A6A12_RS12950	COG0205	6-phosphofructokinase activity
A6A12_RS12955	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A6A12_RS12965	COG0745	RESPONSE REGULATOR receiver
A6A12_RS12970	COG2205	protein histidine kinase activity
A6A12_RS12975	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A6A12_RS12980	COG1278	Cold shock
A6A12_RS12985	COG3030	protein affecting phage T7 exclusion by the F plasmid
A6A12_RS12990	COG1027	Aspartate ammonia-lyase
A6A12_RS12995	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A6A12_RS13000	COG1288	antiporter activity
A6A12_RS13010	COG0549	Belongs to the carbamate kinase family
A6A12_RS13015	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A6A12_RS13025	COG0540	Belongs to the ATCase OTCase family
A6A12_RS13030	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
A6A12_RS13035	COG1438	arginine binding
A6A12_RS13040	COG4232	protein-disulfide reductase activity
A6A12_RS13060	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6A12_RS13065	COG2205	protein histidine kinase activity
A6A12_RS13065	COG2198	Histidine kinase
A6A12_RS13065	COG0784	Response regulator, receiver
A6A12_RS13070	COG2814	Major facilitator Superfamily
A6A12_RS13085	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A6A12_RS13090	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A6A12_RS13095	COG0511	ligase activity, forming carbon-carbon bonds
A6A12_RS13100	COG0439	Biotin carboxylase
A6A12_RS13105	COG2264	protein methyltransferase activity
A6A12_RS13110	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A6A12_RS13115	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
A6A12_RS13125	COG0789	Transcriptional regulator
A6A12_RS13130	COG0138	bifunctional purine biosynthesis protein purh
A6A12_RS13135	COG0151	Belongs to the GarS family
A6A12_RS13145	COG0776	regulation of translation
A6A12_RS13150	COG1253	flavin adenine dinucleotide binding
A6A12_RS13155	COG2852	Protein conserved in bacteria
A6A12_RS13160	COG3068	Protein conserved in bacteria
A6A12_RS13165	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A6A12_RS13170	COG0668	transmembrane transport
A6A12_RS13180	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
A6A12_RS13185	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A6A12_RS13200	COG0438	transferase activity, transferring glycosyl groups
A6A12_RS13205	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A6A12_RS13240	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A6A12_RS13245	COG1596	polysaccharide export
A6A12_RS13265	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A6A12_RS13275	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A6A12_RS13300	COG3754	Rhamnan synthesis protein F
A6A12_RS13330	COG0463	Glycosyl transferase, family 2
A6A12_RS13340	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A6A12_RS13350	COG0028	Belongs to the TPP enzyme family
A6A12_RS13395	COG1682	transport, permease protein
A6A12_RS13420	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A6A12_RS13430	COG3307	-O-antigen
A6A12_RS13435	COG0859	PFAM glycosyl transferase family 9
A6A12_RS13450	COG1519	Transferase
A6A12_RS13460	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A6A12_RS13475	COG3642	lipopolysaccharide core region biosynthetic process
A6A12_RS13480	COG0859	PFAM glycosyl transferase family 9
A6A12_RS13485	COG0463	Glycosyl transferase, family 2
A6A12_RS13490	COG0859	PFAM glycosyl transferase family 9
A6A12_RS13495	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A6A12_RS13500	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A6A12_RS13510	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A6A12_RS13515	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A6A12_RS13520	COG2003	Belongs to the UPF0758 family
A6A12_RS13525	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A6A12_RS13530	COG1309	transcriptional regulator
A6A12_RS13535	COG1560	Kdo2-lipid A biosynthetic process
A6A12_RS13540	COG1560	Kdo2-lipid A biosynthetic process
A6A12_RS13545	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A6A12_RS13550	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
A6A12_RS13555	COG1561	YicC-like family, N-terminal region
A6A12_RS13645	COG2433	Pfam Transposase IS66
A6A12_RS13670	COG2433	Pfam Transposase IS66
A6A12_RS13695	COG0612	Peptidase, M16
A6A12_RS13720	COG1120	ATPase activity
A6A12_RS13725	COG4774	siderophore transport
A6A12_RS13730	COG1132	(ABC) transporter
A6A12_RS13735	COG1263	PTS System
A6A12_RS13735	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6A12_RS13740	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
A6A12_RS13760	COG0514	ATP-dependent DNA helicase (RecQ)
A6A12_RS13765	COG2962	Rard protein
A6A12_RS13775	COG1280	lysine exporter protein (LysE YggA)
A6A12_RS13780	COG0210	DNA helicase
A6A12_RS13785	COG0339	signal peptide processing
A6A12_RS13790	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
A6A12_RS13795	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6A12_RS13835	COG5290	Psort location Cytoplasmic, score
A6A12_RS13845	COG2433	Pfam Transposase IS66
A6A12_RS13865	COG3081	Nucleoid-associated protein
A6A12_RS13885	COG2433	Pfam Transposase IS66
A6A12_RS13940	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6A12_RS13945	COG0601	transmembrane transport
A6A12_RS13995	COG1309	transcriptional regulator
A6A12_RS14000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6A12_RS14005	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A6A12_RS14010	COG2960	long-chain fatty acid transporting porin activity
A6A12_RS14015	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A6A12_RS14035	COG3078	GTPase activator activity
A6A12_RS14055	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6A12_RS14055	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6A12_RS14065	COG0084	hydrolase, TatD family'
A6A12_RS14075	COG0805	protein transport
A6A12_RS14080	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A6A12_RS14085	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A6A12_RS14090	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A6A12_RS14100	COG2226	methyltransferase
A6A12_RS14105	COG1322	Protein conserved in bacteria
A6A12_RS14125	COG2160	L-arabinose isomerase activity
A6A12_RS14135	COG1069	ribulokinase activity
A6A12_RS14140	COG1879	ABC-type sugar transport system periplasmic component
A6A12_RS14145	COG1129	ABC transporter
A6A12_RS14150	COG1172	Belongs to the binding-protein-dependent transport system permease family
A6A12_RS14160	COG2081	HI0933 family
A6A12_RS14175	COG1528	Iron-storage protein
A6A12_RS14180	COG0589	response to stress
A6A12_RS14195	COG0742	ribosomal rna small subunit methyltransferase
A6A12_RS14200	COG1522	sequence-specific DNA binding
A6A12_RS14225	COG0006	proline dipeptidase activity
A6A12_RS14225	COG0006	proline dipeptidase activity
A6A12_RS14230	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A6A12_RS14235	COG2022	thiamine diphosphate biosynthetic process
A6A12_RS14240	COG2104	thiamine diphosphate biosynthetic process
A6A12_RS14250	COG0352	thiamine-phosphate diphosphorylase activity
A6A12_RS14255	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
A6A12_RS14305	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
A6A12_RS14310	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A6A12_RS14315	COG1739	Uncharacterized protein family UPF0029
A6A12_RS14325	COG0183	Belongs to the thiolase family
A6A12_RS14330	COG0583	DNA-binding transcription factor activity
A6A12_RS14335	COG2814	Major facilitator Superfamily
A6A12_RS14345	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A6A12_RS14350	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A6A12_RS14355	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A6A12_RS14360	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A6A12_RS14365	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A6A12_RS14370	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A6A12_RS14385	COG3312	ion transport
A6A12_RS14390	COG1475	DNA binding
A6A12_RS14395	COG1192	Involved in chromosome partitioning
A6A12_RS14405	COG0445	tRNA wobble uridine modification
A6A12_RS14410	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A6A12_RS14420	COG0706	membrane insertase activity
A6A12_RS14440	COG1126	abc transporter atp-binding protein