locus-tag	class	description
VCA1004_RS00005	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VCA1004_RS00015	COG0706	membrane insertase activity
VCA1004_RS00025	COG0594	ribonuclease P activity
VCA1004_RS00035	COG1126	abc transporter atp-binding protein
VCA1004_RS00045	COG4178	(ABC) transporter
VCA1004_RS00060	COG0592	DNA-directed DNA polymerase activity
VCA1004_RS00065	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
VCA1004_RS00070	COG0187	DNA topoisomerase II activity
VCA1004_RS00080	COG0071	Belongs to the small heat shock protein (HSP20) family
VCA1004_RS00095	COG3977	Valine--pyruvate aminotransferase
VCA1004_RS00110	COG0752	glycyl-tRNA synthetase alpha subunit
VCA1004_RS00115	COG1971	Probably functions as a manganese efflux pump
VCA1004_RS00125	COG0425	Belongs to the sulfur carrier protein TusA family
VCA1004_RS00130	COG1965	Belongs to the frataxin family
VCA1004_RS00140	COG0019	diaminopimelate decarboxylase activity
VCA1004_RS00145	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
VCA1004_RS00155	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
VCA1004_RS00160	COG1011	Hydrolase
VCA1004_RS00170	COG3148	PFAM DTW domain containing protein
VCA1004_RS00185	COG0561	phosphatase activity
VCA1004_RS00190	COG2267	carboxylic ester hydrolase activity
VCA1004_RS00215	COG2095	MarC family integral membrane protein
VCA1004_RS00225	COG0742	ribosomal rna small subunit methyltransferase
VCA1004_RS00230	COG0552	protein localization to endoplasmic reticulum
VCA1004_RS00235	COG2884	Cell division ATP-binding protein ftsE
VCA1004_RS00240	COG2177	Part of the ABC transporter FtsEX involved in
VCA1004_RS00250	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VCA1004_RS00255	COG0705	Rhomboid family
VCA1004_RS00260	COG3161	chorismate lyase activity
VCA1004_RS00265	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
VCA1004_RS00270	COG2937	Belongs to the GPAT DAPAT family
VCA1004_RS00285	COG0534	Mate efflux family protein
VCA1004_RS00290	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VCA1004_RS00295	COG1309	transcriptional regulator
VCA1004_RS00300	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VCA1004_RS00305	COG4206	TonB-dependent receptor
VCA1004_RS00310	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
VCA1004_RS00350	COG3071	HemY protein
VCA1004_RS00355	COG2959	enzyme of heme biosynthesis
VCA1004_RS00360	COG1587	Uroporphyrinogen-III synthase
VCA1004_RS00375	COG0183	Belongs to the thiolase family
VCA1004_RS00385	COG1739	Uncharacterized protein family UPF0029
VCA1004_RS00390	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VCA1004_RS00425	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
VCA1004_RS00435	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VCA1004_RS00455	COG0006	proline dipeptidase activity
VCA1004_RS00470	COG1322	Protein conserved in bacteria
VCA1004_RS00475	COG2226	methyltransferase
VCA1004_RS00485	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
VCA1004_RS00490	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VCA1004_RS00495	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VCA1004_RS00500	COG0805	protein transport
VCA1004_RS00505	COG0084	hydrolase, TatD family'
VCA1004_RS00515	COG0248	Ppx GppA phosphatase
VCA1004_RS00520	COG0513	Belongs to the DEAD box helicase family
VCA1004_RS00525	COG3118	belongs to the thioredoxin family
VCA1004_RS00540	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
VCA1004_RS00545	COG0633	Ferredoxin
VCA1004_RS00630	COG0583	DNA-binding transcription factor activity
VCA1004_RS00635	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
VCA1004_RS00640	COG2801	Transposase and inactivated derivatives
VCA1004_RS00645	COG2963	transposase activity
VCA1004_RS00655	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VCA1004_RS00660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VCA1004_RS00665	COG1309	transcriptional regulator
VCA1004_RS00670	COG0210	DNA helicase
VCA1004_RS00705	COG4172	Belongs to the ABC transporter superfamily
VCA1004_RS00710	COG4166	transmembrane transport
VCA1004_RS00715	COG0601	transmembrane transport
VCA1004_RS00720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VCA1004_RS00725	COG0673	inositol 2-dehydrogenase activity
VCA1004_RS00740	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VCA1004_RS00745	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
VCA1004_RS00755	COG0583	DNA-binding transcription factor activity
VCA1004_RS00785	COG1522	sequence-specific DNA binding
VCA1004_RS00790	COG5001	Diguanylate cyclase
VCA1004_RS00790	COG5002	protein histidine kinase activity
VCA1004_RS00800	COG0189	ligase activity
VCA1004_RS00800	COG4067	protein conserved in archaea
VCA1004_RS00815	COG0589	response to stress
VCA1004_RS00820	COG1528	Iron-storage protein
VCA1004_RS00830	COG2081	HI0933 family
VCA1004_RS00835	COG0783	Belongs to the Dps family
VCA1004_RS00840	COG1438	arginine binding
VCA1004_RS00845	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
VCA1004_RS00850	COG0549	Belongs to the carbamate kinase family
VCA1004_RS00860	COG1288	antiporter activity
VCA1004_RS00865	COG0471	metal ion transport
VCA1004_RS00875	COG0210	DNA helicase
VCA1004_RS00880	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
VCA1004_RS00885	COG0205	6-phosphofructokinase activity
VCA1004_RS00910	COG1494	fructose-1,6-bisphosphatase
VCA1004_RS00915	COG3074	FtsZ-dependent cytokinesis
VCA1004_RS00920	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VCA1004_RS00925	COG1575	Belongs to the MenA family. Type 1 subfamily
VCA1004_RS00930	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
VCA1004_RS00935	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
VCA1004_RS00960	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
VCA1004_RS00965	COG0254	rRNA binding
VCA1004_RS00970	COG0281	malic enzyme
VCA1004_RS00975	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
VCA1004_RS00980	COG0626	cystathionine gamma-synthase activity
VCA1004_RS00985	COG0527	aspartate kinase activity
VCA1004_RS00985	COG0460	homoserine dehydrogenase
VCA1004_RS00990	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
VCA1004_RS00995	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
VCA1004_RS01000	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VCA1004_RS01005	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
VCA1004_RS01015	COG0137	argininosuccinate synthase activity
VCA1004_RS01020	COG0165	Argininosuccinate lyase
VCA1004_RS01020	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VCA1004_RS01030	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
VCA1004_RS01065	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
VCA1004_RS01075	COG0338	D12 class N6 adenine-specific DNA methyltransferase
VCA1004_RS01085	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
VCA1004_RS01095	COG0180	Tryptophanyl-tRNA synthetase
VCA1004_RS01100	COG0512	Glutamine amidotransferase of anthranilate synthase
VCA1004_RS01105	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
VCA1004_RS01115	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VCA1004_RS01125	COG0194	GDP metabolic process
VCA1004_RS01135	COG0243	molybdopterin cofactor binding
VCA1004_RS01165	COG0235	Class ii aldolase
VCA1004_RS01170	COG0561	phosphatase activity
VCA1004_RS01175	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
VCA1004_RS01180	COG3623	hexulose-6-phosphate isomerase
VCA1004_RS01190	COG1561	YicC-like family, N-terminal region
VCA1004_RS01195	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
VCA1004_RS01200	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
VCA1004_RS01205	COG0814	amino acid
VCA1004_RS01220	COG3954	Phosphoribulokinase
VCA1004_RS01235	COG0488	(ABC) transporter
VCA1004_RS01240	COG2249	NAD(P)H dehydrogenase (quinone) activity
VCA1004_RS01250	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
VCA1004_RS01255	COG1047	Peptidyl-prolyl cis-trans
VCA1004_RS01260	COG2900	Belongs to the SlyX family
VCA1004_RS01265	COG0545	Peptidyl-prolyl cis-trans isomerase
VCA1004_RS01270	COG2964	Protein conserved in bacteria
VCA1004_RS01275	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
VCA1004_RS01280	COG2923	Belongs to the DsrF TusC family
VCA1004_RS01300	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VCA1004_RS01310	COG0051	transcription antitermination factor activity, RNA binding
VCA1004_RS01315	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
VCA1004_RS01320	COG0088	Forms part of the polypeptide exit tunnel
VCA1004_RS01325	COG0089	rRNA binding
VCA1004_RS01330	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
VCA1004_RS01335	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
VCA1004_RS01340	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
VCA1004_RS01345	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
VCA1004_RS01350	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
VCA1004_RS01375	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
VCA1004_RS01380	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
VCA1004_RS01385	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
VCA1004_RS01390	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
VCA1004_RS01405	COG1841	ribosomal large subunit assembly
VCA1004_RS01410	COG0200	Binds to the 23S rRNA
VCA1004_RS01415	COG0201	protein transport
VCA1004_RS01420	COG0257	Belongs to the bacterial ribosomal protein bL36 family
VCA1004_RS01425	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
VCA1004_RS01440	COG0202	RNA polymerase activity
VCA1004_RS01445	COG0203	ribosomal protein L17
VCA1004_RS01455	COG0545	Peptidyl-prolyl cis-trans isomerase
VCA1004_RS01460	COG3061	Opacity-associated protein A
VCA1004_RS01460	COG3266	domain, Protein
VCA1004_RS01465	COG2153	protein acetylation
VCA1004_RS01470	COG1648	precorrin-2 dehydrogenase activity
VCA1004_RS01470	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VCA1004_RS01475	COG0175	sulfate reduction
VCA1004_RS01480	COG2895	sulfate adenylyltransferase (ATP) activity
VCA1004_RS01485	COG3273	potassium ion transport
VCA1004_RS01485	COG0471	metal ion transport
VCA1004_RS01490	COG0529	Catalyzes the synthesis of activated sulfate
VCA1004_RS01515	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
VCA1004_RS01525	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VCA1004_RS01535	COG2911	Protein conserved in bacteria
VCA1004_RS01540	COG2105	PFAM AIG2 family protein
VCA1004_RS01550	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
VCA1004_RS01555	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
VCA1004_RS01560	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VCA1004_RS01565	COG0163	prenyltransferase activity
VCA1004_RS01570	COG4143	(ABC) transporter
VCA1004_RS01575	COG1178	ABC-type Fe3 transport system permease component
VCA1004_RS01580	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
VCA1004_RS01590	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
VCA1004_RS01595	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
VCA1004_RS01600	COG0564	pseudouridine synthase activity
VCA1004_RS01605	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VCA1004_RS01615	COG1438	arginine binding
VCA1004_RS01620	COG0039	L-malate dehydrogenase activity
VCA1004_RS01625	COG0142	geranyltranstransferase activity
VCA1004_RS01640	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
VCA1004_RS01645	COG2966	Psort location CytoplasmicMembrane, score
VCA1004_RS01655	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
VCA1004_RS01660	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
VCA1004_RS01675	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
VCA1004_RS01680	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VCA1004_RS01685	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
VCA1004_RS01690	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
VCA1004_RS01700	COG0066	3-isopropylmalate dehydratase activity
VCA1004_RS01710	COG0473	3-isopropylmalate dehydrogenase activity
VCA1004_RS01730	COG0583	DNA-binding transcription factor activity
VCA1004_RS01735	COG0028	Belongs to the TPP enzyme family
VCA1004_RS01740	COG0440	acetolactate synthase activity
VCA1004_RS01750	COG1349	DNA-binding transcription factor activity
VCA1004_RS01755	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
VCA1004_RS01760	COG2161	toxin-antitoxin pair type II binding
VCA1004_RS01765	COG4115	mRNA cleavage
VCA1004_RS01770	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
VCA1004_RS01790	COG3047	cAMP biosynthetic process
VCA1004_RS01800	COG1028	Short-chain dehydrogenase reductase Sdr
VCA1004_RS01810	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VCA1004_RS01850	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
VCA1004_RS01860	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VCA1004_RS01865	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VCA1004_RS01890	COG1566	PFAM secretion protein HlyD family protein
VCA1004_RS01910	COG1584	GPR1 FUN34 yaaH family protein
VCA1004_RS01915	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VCA1004_RS01920	COG0701	Predicted permease
VCA1004_RS01930	COG1595	DNA-templated transcription, initiation
VCA1004_RS01950	COG1610	YqeY-like protein
VCA1004_RS01955	COG0828	Belongs to the bacterial ribosomal protein bS21 family
VCA1004_RS01960	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
VCA1004_RS01965	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
VCA1004_RS01970	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
VCA1004_RS01975	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VCA1004_RS01980	COG1968	undecaprenyl-diphosphatase activity
VCA1004_RS01985	COG0617	tRNA 3'-terminal CCA addition
VCA1004_RS01990	COG3267	Type II secretory pathway component ExeA
VCA1004_RS01990	COG3409	Peptidoglycan-binding domain 1 protein
VCA1004_RS02005	COG1752	Esterase of the alpha-beta hydrolase superfamily
VCA1004_RS02010	COG1049	propionate catabolic process, 2-methylcitrate cycle
VCA1004_RS02020	COG4991	sh3 domain protein
VCA1004_RS02025	COG0306	phosphate transporter
VCA1004_RS02030	COG1392	Phosphate transport regulator
VCA1004_RS02035	COG3025	triphosphatase activity
VCA1004_RS02040	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VCA1004_RS02045	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
VCA1004_RS02050	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
VCA1004_RS02050	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
VCA1004_RS02055	COG1538	Outer membrane efflux protein
VCA1004_RS02060	COG0494	nUDIX hydrolase
VCA1004_RS02065	COG3151	Protein conserved in bacteria
VCA1004_RS02075	COG3150	esterase
VCA1004_RS02080	COG0187	DNA topoisomerase II activity
VCA1004_RS02085	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
VCA1004_RS02090	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VCA1004_RS02095	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VCA1004_RS02100	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VCA1004_RS02105	COG3105	Protein conserved in bacteria
VCA1004_RS02110	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
VCA1004_RS02120	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
VCA1004_RS02125	COG0723	plastoquinol--plastocyanin reductase activity
VCA1004_RS02130	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
VCA1004_RS02135	COG2857	Cytochrome c1
VCA1004_RS02140	COG0625	glutathione transferase activity
VCA1004_RS02145	COG2969	positive regulation of protein catabolic process
VCA1004_RS02155	COG2860	membrane
VCA1004_RS02165	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
VCA1004_RS02180	COG0067	glutamate synthase
VCA1004_RS02180	COG0069	glutamate synthase activity
VCA1004_RS02180	COG0070	glutamate synthase
VCA1004_RS02185	COG0784	Response regulator, receiver
VCA1004_RS02185	COG5002	protein histidine kinase activity
VCA1004_RS02185	COG2198	Histidine kinase
VCA1004_RS02190	COG0745	RESPONSE REGULATOR receiver
VCA1004_RS02195	COG2801	Transposase and inactivated derivatives
VCA1004_RS02200	COG2963	transposase activity
VCA1004_RS02210	COG0083	homoserine kinase activity
VCA1004_RS02215	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
VCA1004_RS02225	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
VCA1004_RS02240	COG1115	amino acid carrier protein
VCA1004_RS02245	COG3022	response to hydroperoxide
VCA1004_RS02250	COG0513	Belongs to the DEAD box helicase family
VCA1004_RS02270	COG4974	Belongs to the 'phage' integrase family
VCA1004_RS02280	COG3097	Belongs to the UPF0267 family
VCA1004_RS02285	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
VCA1004_RS02295	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
VCA1004_RS02305	COG0667	Aldo Keto reductase
VCA1004_RS02315	COG3066	DNA modification
VCA1004_RS02335	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
VCA1004_RS02340	COG0583	DNA-binding transcription factor activity
VCA1004_RS02345	COG0640	Transcriptional regulator
VCA1004_RS02355	COG0728	peptidoglycan biosynthetic process
VCA1004_RS02360	COG0196	riboflavin kinase activity
VCA1004_RS02370	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
VCA1004_RS02375	COG1047	Peptidyl-prolyl cis-trans
VCA1004_RS02380	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
VCA1004_RS02395	COG1966	Carbon starvation protein
VCA1004_RS02415	COG0569	domain protein
VCA1004_RS02415	COG0189	ligase activity
VCA1004_RS02425	COG3275	phosphorelay sensor kinase activity
VCA1004_RS02435	COG1605	Chorismate mutase
VCA1004_RS02435	COG0287	Prephenate dehydrogenase
VCA1004_RS02445	COG0739	heme binding
VCA1004_RS02445	COG0741	lytic transglycosylase activity
VCA1004_RS02445	COG1196	nuclear chromosome segregation
VCA1004_RS02450	COG0488	(ABC) transporter
VCA1004_RS02460	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
VCA1004_RS02470	COG0077	Prephenate dehydratase
VCA1004_RS02470	COG1605	Chorismate mutase
VCA1004_RS02475	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VCA1004_RS02480	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VCA1004_RS02485	COG0564	pseudouridine synthase activity
VCA1004_RS02495	COG0542	response to heat
VCA1004_RS02550	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VCA1004_RS02555	COG0826	peptidase U32
VCA1004_RS02560	COG2974	May be involved in recombination
VCA1004_RS02565	COG0745	RESPONSE REGULATOR receiver
VCA1004_RS02570	COG5002	protein histidine kinase activity
VCA1004_RS02580	COG0248	Ppx GppA phosphatase
VCA1004_RS02585	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
VCA1004_RS02590	COG0573	inorganic phosphate transmembrane transporter activity
VCA1004_RS02595	COG0573	inorganic phosphate transmembrane transporter activity
VCA1004_RS02600	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VCA1004_RS02615	COG0450	alkyl hydroperoxide reductase
VCA1004_RS02620	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
VCA1004_RS02630	COG1862	Preprotein translocase
VCA1004_RS02635	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VCA1004_RS02640	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VCA1004_RS02645	COG0483	inositol monophosphate 1-phosphatase activity
VCA1004_RS02660	COG1104	cysteine desulfurase activity
VCA1004_RS02665	COG0822	iron-sulfur transferase activity
VCA1004_RS02675	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
VCA1004_RS02680	COG0443	Heat shock 70 kDa protein
VCA1004_RS02685	COG0633	Ferredoxin
VCA1004_RS02690	COG2975	iron-sulfur cluster assembly
VCA1004_RS02695	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VCA1004_RS02700	COG0105	UTP biosynthetic process
VCA1004_RS02720	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
VCA1004_RS02725	COG0124	histidyl-tRNA synthetase
VCA1004_RS02730	COG2976	Protein conserved in bacteria
VCA1004_RS02735	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VCA1004_RS02740	COG1160	GTP binding
VCA1004_RS02750	COG1570	exodeoxyribonuclease VII activity
VCA1004_RS02755	COG0516	GMP reductase activity
VCA1004_RS02755	COG0517	IMP dehydrogenase activity
VCA1004_RS02760	COG0519	Catalyzes the synthesis of GMP from XMP
VCA1004_RS02760	COG0518	GMP synthase (glutamine-hydrolyzing) activity
VCA1004_RS02770	COG0673	inositol 2-dehydrogenase activity
VCA1004_RS02780	COG0668	transmembrane transport
VCA1004_RS02785	COG0583	DNA-binding transcription factor activity
VCA1004_RS02790	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
VCA1004_RS02805	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
VCA1004_RS02810	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
VCA1004_RS02815	COG1845	cytochrome c oxidase, subunit III
VCA1004_RS02820	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
VCA1004_RS02825	COG0109	protoheme IX farnesyltransferase activity
VCA1004_RS02840	COG3634	alkyl hydroperoxide reductase activity
VCA1004_RS02850	COG1349	DNA-binding transcription factor activity
VCA1004_RS02870	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
VCA1004_RS02875	COG0651	ATP synthesis coupled electron transport
VCA1004_RS02880	COG0650	Formate hydrogenlyase subunit 4
VCA1004_RS02885	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
VCA1004_RS02890	COG4237	Hydrogenase 4 membrane
VCA1004_RS02895	COG0651	ATP synthesis coupled electron transport
VCA1004_RS02900	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
VCA1004_RS02900	COG3261	NADH dehydrogenase
VCA1004_RS02905	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VCA1004_RS02910	COG3260	NADH ubiquinone oxidoreductase 20
VCA1004_RS02920	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
VCA1004_RS02930	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
VCA1004_RS02940	COG3604	Transcriptional regulator
VCA1004_RS02955	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
VCA1004_RS02960	COG0298	carbon dioxide binding
VCA1004_RS02970	COG0309	Hydrogenase expression formation protein (HypE)
VCA1004_RS02975	COG0375	protein maturation
VCA1004_RS02980	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
VCA1004_RS02985	COG2897	thiosulfate sulfurtransferase activity
VCA1004_RS02995	COG1921	L-seryl-tRNASec selenium transferase activity
VCA1004_RS03000	COG0709	Synthesizes selenophosphate from selenide and ATP
VCA1004_RS03005	COG2391	methyltransferase activity
VCA1004_RS03010	COG2194	sulfuric ester hydrolase activity
VCA1004_RS03045	COG2003	Belongs to the UPF0758 family
VCA1004_RS03055	COG4735	regulation of single-species biofilm formation
VCA1004_RS03090	COG1715	Restriction endonuclease
VCA1004_RS03095	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
VCA1004_RS03115	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
VCA1004_RS03120	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
VCA1004_RS03125	COG0582	viral genome integration into host DNA
VCA1004_RS03140	COG2867	negative regulation of translational initiation
VCA1004_RS03145	COG2914	Belongs to the UPF0125 (RnfH) family
VCA1004_RS03150	COG2801	Transposase and inactivated derivatives
VCA1004_RS03155	COG2963	transposase activity
VCA1004_RS03160	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VCA1004_RS03165	COG0497	DNA recombination
VCA1004_RS03170	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
VCA1004_RS03175	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
VCA1004_RS03180	COG0443	Heat shock 70 kDa protein
VCA1004_RS03185	COG0484	heat shock protein binding
VCA1004_RS03195	COG4966	pilus assembly protein PilW
VCA1004_RS03220	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
VCA1004_RS03225	COG0047	phosphoribosylformylglycinamidine synthase activity
VCA1004_RS03225	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
VCA1004_RS03240	COG0514	ATP-dependent DNA helicase (RecQ)
VCA1004_RS03275	COG0442	prolyl-tRNA aminoacylation
VCA1004_RS03280	COG1720	tRNA m6t6A37 methyltransferase activity
VCA1004_RS03290	COG0257	Belongs to the bacterial ribosomal protein bL36 family
VCA1004_RS03295	COG1464	Belongs to the NlpA lipoprotein family
VCA1004_RS03300	COG2011	ABC-type metal ion transport system permease component
VCA1004_RS03305	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
VCA1004_RS03310	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VCA1004_RS03315	COG4174	ABC transporter (Permease)
VCA1004_RS03320	COG4239	(ABC) transporter, permease
VCA1004_RS03325	COG4166	transmembrane transport
VCA1004_RS03330	COG0444	Belongs to the ABC transporter superfamily
VCA1004_RS03335	COG4608	Belongs to the ABC transporter superfamily
VCA1004_RS03360	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
VCA1004_RS03365	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VCA1004_RS03365	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VCA1004_RS03385	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VCA1004_RS03390	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
VCA1004_RS03395	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
VCA1004_RS03405	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
VCA1004_RS03410	COG0142	geranyltranstransferase activity
VCA1004_RS03420	COG0301	tRNA thio-modification
VCA1004_RS03420	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VCA1004_RS03435	COG2363	Small membrane protein
VCA1004_RS03440	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
VCA1004_RS03450	COG1611	Belongs to the LOG family
VCA1004_RS03470	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
VCA1004_RS03475	COG1671	Belongs to the UPF0178 family
VCA1004_RS03495	COG3098	single-species biofilm formation
VCA1004_RS03500	COG0564	pseudouridine synthase activity
VCA1004_RS03510	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
VCA1004_RS03515	COG0024	Methionine aminopeptidase
VCA1004_RS03525	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
VCA1004_RS03540	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
VCA1004_RS03545	COG0575	Belongs to the CDS family
VCA1004_RS03555	COG0750	zinc metalloprotease
VCA1004_RS03560	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VCA1004_RS03565	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
VCA1004_RS03570	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VCA1004_RS03580	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VCA1004_RS03595	COG0587	DNA-directed DNA polymerase activity
VCA1004_RS03600	COG0825	malonyl-CoA metabolic process
VCA1004_RS03610	COG0347	Belongs to the P(II) protein family
VCA1004_RS03615	COG3021	interspecies interaction between organisms
VCA1004_RS03620	COG0741	lytic transglycosylase activity
VCA1004_RS03620	COG1388	LysM domain
VCA1004_RS03625	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VCA1004_RS03630	COG2226	methyltransferase
VCA1004_RS03635	COG0328	RNA-DNA hybrid ribonuclease activity
VCA1004_RS03640	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
VCA1004_RS03645	COG1960	acyl-CoA dehydrogenase activity
VCA1004_RS03650	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VCA1004_RS03655	COG0121	glutamine amidotransferase
VCA1004_RS03660	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
VCA1004_RS03665	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
VCA1004_RS03670	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
VCA1004_RS03680	COG1979	alcohol dehydrogenase
VCA1004_RS03685	COG2130	NADP-dependent
VCA1004_RS03690	COG0583	DNA-binding transcription factor activity
VCA1004_RS03705	COG1393	Belongs to the ArsC family
VCA1004_RS03710	COG4783	chaperone-mediated protein folding
VCA1004_RS03725	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
VCA1004_RS03735	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VCA1004_RS03740	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
VCA1004_RS03760	COG1393	Belongs to the ArsC family
VCA1004_RS03780	COG2837	iron assimilation
VCA1004_RS03785	COG2190	(PTS) system
VCA1004_RS03795	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VCA1004_RS03805	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
VCA1004_RS03815	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
VCA1004_RS03830	COG0789	Transcriptional regulator
VCA1004_RS03835	COG3118	belongs to the thioredoxin family
VCA1004_RS03840	COG1090	epimerase
VCA1004_RS03845	COG0622	Phosphoesterase
VCA1004_RS03860	COG3710	Transcriptional regulator
VCA1004_RS03865	COG0326	Molecular chaperone. Has ATPase activity
VCA1004_RS03875	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
VCA1004_RS03880	COG3104	oligopeptide transport
VCA1004_RS03890	COG0367	asparagine synthase
VCA1004_RS03895	COG0475	glutathione-regulated potassium exporter activity
VCA1004_RS03900	COG1940	carbohydrate kinase activity
VCA1004_RS03900	COG1846	Transcriptional regulator
VCA1004_RS03905	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
VCA1004_RS03910	COG0363	glucosamine-6-phosphate deaminase activity
VCA1004_RS03915	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VCA1004_RS03915	COG1263	PTS System
VCA1004_RS03915	COG2190	(PTS) system
VCA1004_RS03920	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VCA1004_RS03925	COG0735	belongs to the Fur family
VCA1004_RS03930	COG0716	FMN binding
VCA1004_RS03940	COG0596	Alpha beta hydrolase
VCA1004_RS03945	COG2863	cytochrome
VCA1004_RS03950	COG3258	Cytochrome c
VCA1004_RS03955	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
VCA1004_RS03960	COG0033	Phosphoglucomutase
VCA1004_RS03970	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
VCA1004_RS03985	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
VCA1004_RS03990	COG1053	succinate dehydrogenase
VCA1004_RS04000	COG0567	Dehydrogenase, E1 component
VCA1004_RS04005	COG0508	dehydrogenase complex catalyzes the overall conversion of
VCA1004_RS04025	COG0366	Alpha amylase catalytic
VCA1004_RS04030	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VCA1004_RS04035	COG1121	(ABC) transporter
VCA1004_RS04040	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
VCA1004_RS04045	COG0739	heme binding
VCA1004_RS04055	COG1918	ferrous iron import across plasma membrane
VCA1004_RS04070	COG0018	arginyl-trna synthetase
VCA1004_RS04075	COG3102	Protein conserved in bacteria
VCA1004_RS04080	COG0788	formyltetrahydrofolate deformylase activity
VCA1004_RS04085	COG1199	ATP-dependent helicase activity
VCA1004_RS04090	COG1214	PFAM Peptidase M22, glycoprotease
VCA1004_RS04100	COG0596	Alpha beta hydrolase
VCA1004_RS04105	COG0318	PFAM AMP-dependent synthetase and ligase
VCA1004_RS04110	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
VCA1004_RS04115	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
VCA1004_RS04120	COG2894	cell division
VCA1004_RS04130	COG3100	YcgL domain-containing protein
VCA1004_RS04135	COG2951	lytic endotransglycosylase activity
VCA1004_RS04140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VCA1004_RS04145	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VCA1004_RS04155	COG2207	Transcriptional regulator
VCA1004_RS04160	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
VCA1004_RS04170	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
VCA1004_RS04175	COG0583	DNA-binding transcription factor activity
VCA1004_RS04185	COG0814	amino acid
VCA1004_RS04195	COG0243	molybdopterin cofactor binding
VCA1004_RS04200	COG0437	4 iron, 4 sulfur cluster binding
VCA1004_RS04225	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
VCA1004_RS04230	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
VCA1004_RS04235	COG0776	regulation of translation
VCA1004_RS04240	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VCA1004_RS04245	COG1555	photosystem II stabilization
VCA1004_RS04260	COG0232	Belongs to the dGTPase family. Type 2 subfamily
VCA1004_RS04265	COG5001	Diguanylate cyclase
VCA1004_RS04265	COG1716	ATPase activity
VCA1004_RS04270	COG2205	protein histidine kinase activity
VCA1004_RS04270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VCA1004_RS04285	COG3121	Chaperone
VCA1004_RS04290	COG3188	usher protein
VCA1004_RS04305	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
VCA1004_RS04310	COG0436	Aminotransferase
VCA1004_RS04315	COG1169	isochorismate synthase
VCA1004_RS04320	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
VCA1004_RS04335	COG0318	PFAM AMP-dependent synthetase and ligase
VCA1004_RS04340	COG2855	membrane
VCA1004_RS04355	COG0280	phosphate acetyltransferase
VCA1004_RS04355	COG0857	belongs to the CobB CobQ family
VCA1004_RS04360	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
VCA1004_RS04365	COG3092	negative regulation of chromosome organization
VCA1004_RS04375	COG4120	Belongs to the binding-protein-dependent transport system permease family
VCA1004_RS04380	COG1122	ATPase activity
VCA1004_RS04385	COG2203	Gaf domain
VCA1004_RS04385	COG2199	diguanylate cyclase activity
VCA1004_RS04390	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VCA1004_RS04395	COG0653	protein targeting
VCA1004_RS04400	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
VCA1004_RS04405	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VCA1004_RS04410	COG2963	transposase activity
VCA1004_RS04415	COG2801	Transposase and inactivated derivatives
VCA1004_RS04420	COG2186	Transcriptional regulator
VCA1004_RS04440	COG0489	protein tyrosine kinase activity
VCA1004_RS04445	COG0572	uridine kinase
VCA1004_RS04450	COG0717	Belongs to the dCTP deaminase family
VCA1004_RS04455	COG2982	Protein involved in outer membrane biogenesis
VCA1004_RS04460	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
VCA1004_RS04465	COG0659	secondary active sulfate transmembrane transporter activity
VCA1004_RS04470	COG1530	ribonuclease E activity
VCA1004_RS04475	COG0564	pseudouridine synthase activity
VCA1004_RS04480	COG0424	maF-like protein
VCA1004_RS04485	COG1399	metal-binding, possibly nucleic acid-binding protein
VCA1004_RS04500	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VCA1004_RS04505	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
VCA1004_RS04520	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VCA1004_RS04530	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
VCA1004_RS04535	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
VCA1004_RS04540	COG0470	DNA polymerase III
VCA1004_RS04545	COG0084	hydrolase, TatD family'
VCA1004_RS04550	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VCA1004_RS04550	COG1263	PTS System
VCA1004_RS04550	COG2190	(PTS) system
VCA1004_RS04565	COG0733	neurotransmitter:sodium symporter activity
VCA1004_RS04570	COG4667	esterase of the alpha-beta hydrolase superfamily
VCA1004_RS04575	COG0469	pyruvate kinase activity
VCA1004_RS04580	COG1940	carbohydrate kinase activity
VCA1004_RS04585	COG1028	Short-chain dehydrogenase reductase Sdr
VCA1004_RS04590	COG0616	signal peptide processing
VCA1004_RS04595	COG2116	formate transmembrane transporter activity
VCA1004_RS04605	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VCA1004_RS04645	COG1674	ftsk spoiiie
VCA1004_RS04650	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
VCA1004_RS04655	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
VCA1004_RS04660	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
VCA1004_RS04665	COG2801	Transposase and inactivated derivatives
VCA1004_RS04670	COG2963	transposase activity
VCA1004_RS04675	COG0189	ligase activity
VCA1004_RS04675	COG4067	protein conserved in archaea
VCA1004_RS04690	COG0156	8-amino-7-oxononanoate synthase activity
VCA1004_RS04695	COG2226	methyltransferase
VCA1004_RS04700	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
VCA1004_RS04705	COG0501	Belongs to the peptidase M48B family
VCA1004_RS04720	COG0730	response to heat
VCA1004_RS04725	COG1199	ATP-dependent helicase activity
VCA1004_RS04735	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VCA1004_RS04740	COG2916	Histone family protein nucleoid-structuring protein H-NS
VCA1004_RS04745	COG1757	Na H antiporter
VCA1004_RS04750	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
VCA1004_RS04755	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
VCA1004_RS04760	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VCA1004_RS04765	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VCA1004_RS04765	COG0131	Imidazoleglycerol-phosphate dehydratase
VCA1004_RS04770	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
VCA1004_RS04785	COG0140	phosphoribosyl-ATP diphosphatase activity
VCA1004_RS04785	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
VCA1004_RS04795	COG1566	PFAM secretion protein HlyD family protein
VCA1004_RS04805	COG3012	SEC-C Motif Domain Protein
VCA1004_RS04810	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VCA1004_RS04815	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VCA1004_RS04820	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VCA1004_RS04825	COG0215	cysteine-tRNA ligase activity
VCA1004_RS04845	COG4067	protein conserved in archaea
VCA1004_RS04845	COG0189	ligase activity
VCA1004_RS04850	COG0500	methyltransferase
VCA1004_RS04855	COG4106	trans-aconitate 2-methyltransferase activity
VCA1004_RS04865	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
VCA1004_RS04870	COG0632	four-way junction helicase activity
VCA1004_RS04880	COG1271	oxidase subunit
VCA1004_RS04885	COG1294	oxidase, subunit
VCA1004_RS04890	COG4890	Cyd operon protein YbgT
VCA1004_RS04900	COG0824	Thioesterase
VCA1004_RS04905	COG0811	peptide transport
VCA1004_RS04910	COG0848	biopolymer transport protein
VCA1004_RS04920	COG0823	Involved in the tonB-independent uptake of proteins
VCA1004_RS04925	COG2885	chlorophyll binding
VCA1004_RS04930	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
VCA1004_RS04970	COG0564	pseudouridine synthase activity
VCA1004_RS04975	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VCA1004_RS04990	COG2350	Protein conserved in bacteria
VCA1004_RS04995	COG1607	acyl-coa hydrolase
VCA1004_RS05005	COG0159	tryptophan synthase activity
VCA1004_RS05010	COG0133	tryptophan synthase activity
VCA1004_RS05015	COG0134	indole-3-glycerol-phosphate synthase activity
VCA1004_RS05015	COG0135	phosphoribosylanthranilate isomerase activity
VCA1004_RS05025	COG0512	Glutamine amidotransferase of anthranilate synthase
VCA1004_RS05030	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VCA1004_RS05035	COG0613	PHP domain protein
VCA1004_RS05040	COG0009	L-threonylcarbamoyladenylate synthase
VCA1004_RS05065	COG0417	DNA replication proofreading
VCA1004_RS05070	COG2197	response regulator
VCA1004_RS05075	COG0322	excinuclease ABC activity
VCA1004_RS05115	COG0826	peptidase U32
VCA1004_RS05120	COG2194	sulfuric ester hydrolase activity
VCA1004_RS05145	COG1215	transferase activity, transferring glycosyl groups
VCA1004_RS05150	COG1215	transferase activity, transferring glycosyl groups
VCA1004_RS05155	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
VCA1004_RS05160	COG3118	belongs to the thioredoxin family
VCA1004_RS05160	COG0457	Tetratricopeptide repeat
VCA1004_RS05165	COG3706	GGDEF domain
VCA1004_RS05170	COG0668	transmembrane transport
VCA1004_RS05175	COG1166	arginine decarboxylase activity
VCA1004_RS05180	COG0010	Belongs to the arginase family
VCA1004_RS05195	COG1032	radical SAM domain protein
VCA1004_RS05200	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
VCA1004_RS05220	COG0583	DNA-binding transcription factor activity
VCA1004_RS05225	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
VCA1004_RS05240	COG3313	Fe-S protein
VCA1004_RS05250	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
VCA1004_RS05255	COG1061	Type III restriction enzyme res subunit
VCA1004_RS05260	COG2067	long-chain fatty acid transport protein
VCA1004_RS05270	COG2814	Major facilitator Superfamily
VCA1004_RS05280	COG4181	ATPase activity
VCA1004_RS05295	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VCA1004_RS05315	COG2020	methyltransferase activity
VCA1004_RS05320	COG0252	asparaginase activity
VCA1004_RS05325	COG2985	domain, Protein
VCA1004_RS05325	COG3273	potassium ion transport
VCA1004_RS05330	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VCA1004_RS05335	COG1737	Transcriptional regulator
VCA1004_RS05340	COG0076	glutamate decarboxylase activity
VCA1004_RS05350	COG2431	L-lysine efflux transmembrane transporter activity
VCA1004_RS05355	COG3070	regulator of competence-specific genes
VCA1004_RS05370	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
VCA1004_RS05375	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
VCA1004_RS05380	COG4988	ABC transporter
VCA1004_RS05385	COG0492	ferredoxin-NADP+ reductase activity
VCA1004_RS05400	COG2949	membrane
VCA1004_RS05405	COG0281	malic enzyme
VCA1004_RS05425	COG2133	pyrroloquinoline quinone binding
VCA1004_RS05435	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VCA1004_RS05435	COG0072	phenylalanine-tRNA ligase activity
VCA1004_RS05440	COG4235	cytochrome complex assembly
VCA1004_RS05440	COG3088	subunit of a heme lyase
VCA1004_RS05445	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
VCA1004_RS05455	COG0437	4 iron, 4 sulfur cluster binding
VCA1004_RS05460	COG3301	Polysulphide reductase, NrfD
VCA1004_RS05465	COG1138	Cytochrome C-type biogenesis protein
VCA1004_RS05470	COG4235	cytochrome complex assembly
VCA1004_RS05470	COG3088	subunit of a heme lyase
VCA1004_RS05485	COG0776	regulation of translation
VCA1004_RS05495	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
VCA1004_RS05500	COG0295	cytidine deaminase activity
VCA1004_RS05505	COG1346	cytolysis
VCA1004_RS05515	COG2925	Exonuclease
VCA1004_RS05530	COG1643	Atp-dependent helicase
VCA1004_RS05570	COG1280	lysine exporter protein (LysE YggA)
VCA1004_RS05580	COG1666	GTP binding
VCA1004_RS05585	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VCA1004_RS05610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VCA1004_RS05620	COG3008	intermembrane lipid transfer
VCA1004_RS05625	COG2995	paraquat-inducible protein a
VCA1004_RS05630	COG1132	(ABC) transporter
VCA1004_RS05635	COG1956	GAF domain-containing protein
VCA1004_RS05640	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
VCA1004_RS05655	COG0308	aminopeptidase N
VCA1004_RS05660	COG2902	Dehydrogenase
VCA1004_RS05665	COG0167	dihydroorotate dehydrogenase activity
VCA1004_RS05685	COG0488	(ABC) transporter
VCA1004_RS05700	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VCA1004_RS05705	COG1067	ATP-dependent peptidase activity
VCA1004_RS05725	COG0534	Mate efflux family protein
VCA1004_RS05730	COG0023	Translation Initiation Factor
VCA1004_RS05755	COG0583	DNA-binding transcription factor activity
VCA1004_RS05760	COG1629	transport
VCA1004_RS05760	COG4771	TonB-dependent receptor
VCA1004_RS05765	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VCA1004_RS05795	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VCA1004_RS05800	COG3118	belongs to the thioredoxin family
VCA1004_RS05810	COG0602	queuosine metabolic process
VCA1004_RS05815	COG0720	synthase
VCA1004_RS05835	COG4533	DNA binding
VCA1004_RS05845	COG2050	protein possibly involved in aromatic compounds catabolism
VCA1004_RS05855	COG0748	coenzyme F420 binding
VCA1004_RS05860	COG3721	Heme iron utilization protein
VCA1004_RS05865	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
VCA1004_RS05870	COG0811	peptide transport
VCA1004_RS05875	COG0848	biopolymer transport protein
VCA1004_RS05885	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VCA1004_RS05890	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
VCA1004_RS05910	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
VCA1004_RS05915	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
VCA1004_RS05920	COG2353	YceI-like domain
VCA1004_RS05925	COG3038	cytochrome b561
VCA1004_RS05930	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
VCA1004_RS05935	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
VCA1004_RS05945	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VCA1004_RS05965	COG2425	protein containing a von Willebrand factor type A (vWA) domain
VCA1004_RS05980	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
VCA1004_RS05990	COG0513	Belongs to the DEAD box helicase family
VCA1004_RS05995	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
VCA1004_RS06000	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VCA1004_RS06025	COG0545	Peptidyl-prolyl cis-trans isomerase
VCA1004_RS06030	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VCA1004_RS06040	COG0302	gtp cyclohydrolase
VCA1004_RS06050	COG0861	Integral membrane protein TerC family
VCA1004_RS06055	COG0737	Belongs to the 5'-nucleotidase family
VCA1004_RS06060	COG3593	DNA synthesis involved in DNA repair
VCA1004_RS06065	COG0561	phosphatase activity
VCA1004_RS06070	COG2217	Heavy metal translocating P-type atpase
VCA1004_RS06075	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VCA1004_RS06075	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VCA1004_RS06075	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VCA1004_RS06080	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VCA1004_RS06080	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
VCA1004_RS06080	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VCA1004_RS06085	COG2207	Transcriptional regulator
VCA1004_RS06090	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VCA1004_RS06090	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VCA1004_RS06090	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VCA1004_RS06100	COG0488	(ABC) transporter
VCA1004_RS06105	COG2963	transposase activity
VCA1004_RS06110	COG2801	Transposase and inactivated derivatives
VCA1004_RS06120	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
VCA1004_RS06125	COG0513	Belongs to the DEAD box helicase family
VCA1004_RS06130	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
VCA1004_RS06140	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
VCA1004_RS06150	COG2824	Alkylphosphonate utilization operon protein PhnA
VCA1004_RS06170	COG3768	UPF0283 membrane protein
VCA1004_RS06175	COG3106	COG3106 Predicted ATPase
VCA1004_RS06200	COG0814	amino acid
VCA1004_RS06205	COG1760	l-serine dehydratase
VCA1004_RS06210	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VCA1004_RS06215	COG0251	oxidation-reduction process
VCA1004_RS06225	COG0017	Asparaginyl-tRNA synthetase
VCA1004_RS06230	COG0861	Integral membrane protein TerC family
VCA1004_RS06235	COG2807	transmembrane transport
VCA1004_RS06245	COG1448	Aminotransferase
VCA1004_RS06250	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VCA1004_RS06265	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VCA1004_RS06280	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VCA1004_RS06290	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VCA1004_RS06300	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VCA1004_RS06305	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VCA1004_RS06355	COG1022	Amp-dependent synthetase and ligase
VCA1004_RS06370	COG2831	hemolysin activation secretion protein
VCA1004_RS06375	COG0733	neurotransmitter:sodium symporter activity
VCA1004_RS06385	COG0626	cystathionine gamma-synthase activity
VCA1004_RS06410	COG2818	Glycosylase
VCA1004_RS06415	COG1983	PspC domain protein
VCA1004_RS06425	COG1842	Phage shock protein A
VCA1004_RS06430	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
VCA1004_RS06435	COG4166	transmembrane transport
VCA1004_RS06440	COG4168	peptide transport system, permease
VCA1004_RS06455	COG4172	Belongs to the ABC transporter superfamily
VCA1004_RS06460	COG2204	response regulator
VCA1004_RS06465	COG0471	metal ion transport
VCA1004_RS06475	COG1227	inorganic diphosphatase activity
VCA1004_RS06495	COG0583	DNA-binding transcription factor activity
VCA1004_RS06505	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
VCA1004_RS06510	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
VCA1004_RS06515	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VCA1004_RS06520	COG1434	Gram-negative-bacterium-type cell wall biogenesis
VCA1004_RS06525	COG1609	Transcriptional regulator
VCA1004_RS06530	COG4134	Bacterial extracellular solute-binding protein
VCA1004_RS06535	COG4135	transport system, permease component
VCA1004_RS06540	COG4136	ATPase activity
VCA1004_RS06545	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
VCA1004_RS06555	COG0596	Alpha beta hydrolase
VCA1004_RS06560	COG0284	orotidine-5'-phosphate decarboxylase activity
VCA1004_RS06565	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
VCA1004_RS06570	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
VCA1004_RS06575	COG0776	regulation of translation
VCA1004_RS06580	COG0539	negative regulation of cytoplasmic translation
VCA1004_RS06595	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
VCA1004_RS06600	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
VCA1004_RS06605	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
VCA1004_RS06610	COG0542	response to heat
VCA1004_RS06615	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
VCA1004_RS06620	COG1278	Cold shock
VCA1004_RS06630	COG1187	pseudouridine synthase activity
VCA1004_RS06640	COG2915	High frequency lysogenization protein hflD homolog
VCA1004_RS06645	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
VCA1004_RS06655	COG2850	peptidyl-arginine hydroxylation
VCA1004_RS06660	COG0708	Exodeoxyribonuclease III
VCA1004_RS06665	COG4160	amino acid transport
VCA1004_RS06685	COG1882	Formate acetyltransferase
VCA1004_RS06690	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VCA1004_RS06700	COG2766	serine protein kinase
VCA1004_RS06705	COG2718	Belongs to the UPF0229 family
VCA1004_RS06710	COG2719	SpoVR family
VCA1004_RS06720	COG2132	Multicopper oxidase
VCA1004_RS06765	COG2835	tetraacyldisaccharide 4'-kinase activity
VCA1004_RS06770	COG1663	tetraacyldisaccharide 4'-kinase activity
VCA1004_RS06775	COG1132	(ABC) transporter
VCA1004_RS06780	COG2333	competence protein COMEC
VCA1004_RS06780	COG0658	competence protein
VCA1004_RS06790	COG4591	ABC-type transport system involved in lipoprotein release permease component
VCA1004_RS06795	COG1136	(ABC) transporter
VCA1004_RS06800	COG4591	ABC-type transport system involved in lipoprotein release permease component
VCA1004_RS06805	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
VCA1004_RS06820	COG1252	NADH dehydrogenase
VCA1004_RS06825	COG3150	esterase
VCA1004_RS06850	COG0537	adenosine 5'-monophosphoramidase activity
VCA1004_RS06865	COG0517	IMP dehydrogenase activity
VCA1004_RS06865	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
VCA1004_RS06865	COG0617	tRNA 3'-terminal CCA addition
VCA1004_RS06870	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VCA1004_RS06870	COG3153	acetyltransferase
VCA1004_RS06885	COG4667	esterase of the alpha-beta hydrolase superfamily
VCA1004_RS06920	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VCA1004_RS06965	COG1946	Acyl-CoA thioesterase
VCA1004_RS06970	COG1522	sequence-specific DNA binding
VCA1004_RS06985	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VCA1004_RS07030	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VCA1004_RS07040	COG0435	Glutathione S-transferase
VCA1004_RS07050	COG2723	6-phospho-beta-galactosidase activity
VCA1004_RS07055	COG1940	carbohydrate kinase activity
VCA1004_RS07070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VCA1004_RS07075	COG0601	transmembrane transport
VCA1004_RS07090	COG0314	molybdopterin synthase activity
VCA1004_RS07095	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
VCA1004_RS07105	COG0521	Mo-molybdopterin cofactor biosynthetic process
VCA1004_RS07110	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
VCA1004_RS07115	COG0391	Required for morphogenesis under gluconeogenic growth conditions
VCA1004_RS07120	COG0556	nucleotide-excision repair
VCA1004_RS07130	COG4657	Part of a membrane complex involved in electron transport
VCA1004_RS07135	COG2878	Part of a membrane complex involved in electron transport
VCA1004_RS07140	COG4656	Part of a membrane complex involved in electron transport
VCA1004_RS07145	COG4658	electron transport chain
VCA1004_RS07150	COG4659	FMN binding
VCA1004_RS07155	COG4660	Part of a membrane complex involved in electron transport
VCA1004_RS07160	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
VCA1004_RS07165	COG0346	lactoylglutathione lyase activity
VCA1004_RS07175	COG2056	Na+-H+ antiporter family
VCA1004_RS07185	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
VCA1004_RS07200	COG1454	alcohol dehydrogenase
VCA1004_RS07200	COG1012	belongs to the aldehyde dehydrogenase family
VCA1004_RS07205	COG2095	MarC family integral membrane protein
VCA1004_RS07210	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VCA1004_RS07215	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VCA1004_RS07220	COG3081	Nucleoid-associated protein
VCA1004_RS07225	COG3082	Protein of unknown function (DUF1414)
VCA1004_RS07230	COG3083	sulfuric ester hydrolase activity
VCA1004_RS07245	COG1335	isochorismatase
VCA1004_RS07260	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VCA1004_RS07265	COG0778	Nitroreductase
VCA1004_RS07270	COG0446	pyridine nucleotide-disulphide oxidoreductase
VCA1004_RS07270	COG1902	pentaerythritol trinitrate reductase activity
VCA1004_RS07275	COG0616	signal peptide processing
VCA1004_RS07280	COG0252	asparaginase activity
VCA1004_RS07285	COG3139	Protein of unknown function (DUF1315)
VCA1004_RS07290	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VCA1004_RS07295	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VCA1004_RS07305	COG2226	methyltransferase
VCA1004_RS07310	COG2356	endonuclease I
VCA1004_RS07325	COG2983	Belongs to the UPF0260 family
VCA1004_RS07335	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
VCA1004_RS07340	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
VCA1004_RS07350	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
VCA1004_RS07355	COG2832	Protein of unknown function (DUF454)
VCA1004_RS07360	COG0745	RESPONSE REGULATOR receiver
VCA1004_RS07365	COG0583	DNA-binding transcription factor activity
VCA1004_RS07370	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
VCA1004_RS07375	COG1286	toxin biosynthetic process
VCA1004_RS07380	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
VCA1004_RS07385	COG0285	dihydrofolate synthase activity
VCA1004_RS07390	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
VCA1004_RS07395	COG0101	tRNA pseudouridine synthase activity
VCA1004_RS07405	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VCA1004_RS07410	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VCA1004_RS07415	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VCA1004_RS07420	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VCA1004_RS07420	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
VCA1004_RS07435	COG3101	peptidyl-lysine hydroxylation
VCA1004_RS07440	COG2860	membrane
VCA1004_RS07445	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
VCA1004_RS07450	COG2890	protein-(glutamine-N5) methyltransferase activity
VCA1004_RS07455	COG2840	Smr protein MutS2
VCA1004_RS07460	COG2062	phosphohistidine phosphatase, SixA
VCA1004_RS07465	COG1025	Belongs to the peptidase M16 family
VCA1004_RS07470	COG1024	Enoyl-CoA hydratase
VCA1004_RS07470	COG1250	3-hydroxyacyl-CoA dehydrogenase
VCA1004_RS07475	COG0183	Belongs to the thiolase family
VCA1004_RS07480	COG1595	DNA-templated transcription, initiation
VCA1004_RS07490	COG2067	long-chain fatty acid transport protein
VCA1004_RS07510	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VCA1004_RS07515	COG1138	Cytochrome C-type biogenesis protein
VCA1004_RS07530	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VCA1004_RS07535	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VCA1004_RS07540	COG4133	protoheme IX ABC transporter activity
VCA1004_RS07550	COG0415	Belongs to the DNA photolyase family
VCA1004_RS07565	COG1132	(ABC) transporter
VCA1004_RS07570	COG4774	siderophore transport
VCA1004_RS07575	COG1120	ATPase activity
VCA1004_RS07595	COG0488	(ABC) transporter
VCA1004_RS07605	COG0443	Heat shock 70 kDa protein
VCA1004_RS07635	COG0848	biopolymer transport protein
VCA1004_RS07640	COG0811	peptide transport
VCA1004_RS07645	COG0811	peptide transport
VCA1004_RS07665	COG2217	Heavy metal translocating P-type atpase
VCA1004_RS07665	COG2608	mercury ion transmembrane transporter activity
VCA1004_RS07675	COG0493	'glutamate synthase
VCA1004_RS07675	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
VCA1004_RS07690	COG2840	Smr protein MutS2
VCA1004_RS07695	COG1187	pseudouridine synthase activity
VCA1004_RS07780	COG0737	Belongs to the 5'-nucleotidase family
VCA1004_RS07785	COG2877	3-deoxy-8-phosphooctulonate synthase activity
VCA1004_RS07790	COG2912	Transglutaminase-like superfamily
VCA1004_RS07795	COG3094	Invasion gene expression up-regulator, SirB
VCA1004_RS07800	COG2890	protein-(glutamine-N5) methyltransferase activity
VCA1004_RS07805	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
VCA1004_RS07810	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
VCA1004_RS07820	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
VCA1004_RS07825	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
VCA1004_RS07830	COG0193	aminoacyl-tRNA hydrolase activity
VCA1004_RS07895	COG2706	6-phosphogluconolactonase activity
VCA1004_RS07900	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VCA1004_RS07910	COG1702	phosphate starvation-inducible protein PhoH
VCA1004_RS07915	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
VCA1004_RS07920	COG4535	Mg2 and Co2 transporter CorC
VCA1004_RS07925	COG0815	Transfers the fatty acyl group on membrane lipoproteins
VCA1004_RS07930	COG0471	metal ion transport
VCA1004_RS07940	COG3069	C4-dicarboxylate transmembrane transporter activity
VCA1004_RS07945	COG2888	peptidyl-tyrosine sulfation
VCA1004_RS07950	COG0495	leucyl-tRNA aminoacylation
VCA1004_RS07955	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
VCA1004_RS07960	COG1466	dna polymerase III delta subunit
VCA1004_RS07965	COG0799	negative regulation of ribosome biogenesis
VCA1004_RS07970	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
VCA1004_RS07975	COG0768	penicillin binding
VCA1004_RS07980	COG0772	Belongs to the SEDS family
VCA1004_RS07985	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
VCA1004_RS07990	COG1686	Belongs to the peptidase S11 family
VCA1004_RS08005	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
VCA1004_RS08010	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
VCA1004_RS08015	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
VCA1004_RS08025	COG1073	alpha beta
VCA1004_RS08035	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
VCA1004_RS08040	COG2252	PERMEase
VCA1004_RS08045	COG2195	Cleaves the N-terminal amino acid of tripeptides
VCA1004_RS08050	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
VCA1004_RS08060	COG1477	protein flavinylation
VCA1004_RS08065	COG2871	sodium ion transport
VCA1004_RS08070	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VCA1004_RS08080	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VCA1004_RS08085	COG1805	sodium ion transport
VCA1004_RS08090	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VCA1004_RS08095	COG0271	Belongs to the BolA IbaG family
VCA1004_RS08110	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VCA1004_RS08125	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
VCA1004_RS08130	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VCA1004_RS08145	COG2166	iron-sulfur cluster assembly
VCA1004_RS08150	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
VCA1004_RS08155	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
VCA1004_RS08160	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VCA1004_RS08160	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VCA1004_RS08165	COG2731	YhcH YjgK YiaL family protein
VCA1004_RS08170	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
VCA1004_RS08175	COG1074	ATP-dependent DNA helicase activity
VCA1004_RS08180	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
VCA1004_RS08190	COG0583	DNA-binding transcription factor activity
VCA1004_RS08195	COG3141	response to X-ray
VCA1004_RS08200	COG1584	GPR1 FUN34 yaaH family protein
VCA1004_RS08205	COG2171	N-acyltransferase activity
VCA1004_RS08210	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
VCA1004_RS08215	COG3835	regulator
VCA1004_RS08220	COG1929	Belongs to the glycerate kinase type-1 family
VCA1004_RS08225	COG1022	Amp-dependent synthetase and ligase
VCA1004_RS08230	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
VCA1004_RS08235	COG0402	S-adenosylhomocysteine deaminase activity
VCA1004_RS08240	COG4628	conserved protein (DUF2132)
VCA1004_RS08245	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VCA1004_RS08250	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VCA1004_RS08260	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
VCA1004_RS08265	COG0560	Phosphoserine phosphatase
VCA1004_RS08275	COG0813	purine-nucleoside phosphorylase activity
VCA1004_RS08285	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
VCA1004_RS08290	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
VCA1004_RS08295	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VCA1004_RS08300	COG0084	hydrolase, TatD family'
VCA1004_RS08310	COG0456	acetyltransferase
VCA1004_RS08325	COG3154	lipid carrier protein
VCA1004_RS08330	COG0826	peptidase U32
VCA1004_RS08335	COG0826	peptidase U32
VCA1004_RS08360	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
VCA1004_RS08370	COG0195	Participates in both transcription termination and antitermination
VCA1004_RS08375	COG0779	Required for maturation of 30S ribosomal subunits
VCA1004_RS08390	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VCA1004_RS08400	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
VCA1004_RS08405	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VCA1004_RS08415	COG1534	Rna-binding protein
VCA1004_RS08420	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VCA1004_RS08425	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VCA1004_RS08430	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VCA1004_RS08435	COG2027	D-alanyl-D-alanine carboxypeptidase
VCA1004_RS08440	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
VCA1004_RS08445	COG0505	Belongs to the CarA family
VCA1004_RS08450	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
VCA1004_RS08455	COG0335	large ribosomal subunit rRNA binding
VCA1004_RS08460	COG0336	Belongs to the RNA methyltransferase TrmD family
VCA1004_RS08465	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
VCA1004_RS08475	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
VCA1004_RS08480	COG4137	Cytochrome C assembly protein
VCA1004_RS08485	COG4536	flavin adenine dinucleotide binding
VCA1004_RS08490	COG1854	S-ribosylhomocysteine lyase activity
VCA1004_RS08500	COG0612	Peptidase, M16
VCA1004_RS08505	COG1238	metal cluster binding
VCA1004_RS08560	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
VCA1004_RS08575	COG1546	Belongs to the CinA family
VCA1004_RS08580	COG2358	TRAP transporter, solute receptor (TAXI family
VCA1004_RS08590	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
VCA1004_RS08595	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VCA1004_RS08600	COG4942	peptidase
VCA1004_RS08600	COG1388	LysM domain
VCA1004_RS08610	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
VCA1004_RS08615	COG0585	pseudouridine synthase activity
VCA1004_RS08620	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
VCA1004_RS08625	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
VCA1004_RS08630	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
VCA1004_RS08640	COG0148	phosphopyruvate hydratase activity
VCA1004_RS08650	COG3956	TIGRFAM MazG family protein
VCA1004_RS08655	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VCA1004_RS08660	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VCA1004_RS08665	COG3437	response regulator, receiver
VCA1004_RS08665	COG2205	protein histidine kinase activity
VCA1004_RS08665	COG3850	Histidine kinase
VCA1004_RS08665	COG4999	Histidine kinase
VCA1004_RS08670	COG0736	holo-[acyl-carrier-protein] synthase activity
VCA1004_RS08675	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
VCA1004_RS08685	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
VCA1004_RS08690	COG0571	ribonuclease III activity
VCA1004_RS08695	COG0681	Belongs to the peptidase S26 family
VCA1004_RS08700	COG0481	GTPase activity
VCA1004_RS08705	COG3086	response to oxidative stress
VCA1004_RS08715	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
VCA1004_RS08720	COG1595	DNA-templated transcription, initiation
VCA1004_RS08725	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
VCA1004_RS08730	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
VCA1004_RS08735	COG0354	folic acid binding
VCA1004_RS08745	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VCA1004_RS08750	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VCA1004_RS08760	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
VCA1004_RS08770	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
VCA1004_RS08775	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
VCA1004_RS08780	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VCA1004_RS08785	COG2963	transposase activity
VCA1004_RS08790	COG2801	Transposase and inactivated derivatives
VCA1004_RS08800	COG0668	transmembrane transport
VCA1004_RS08805	COG0191	fructose-bisphosphate aldolase activity
VCA1004_RS08810	COG0126	phosphoglycerate kinase activity
VCA1004_RS08815	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VCA1004_RS08825	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VCA1004_RS08845	COG1385	rRNA (uridine-N3-)-methyltransferase activity
VCA1004_RS08855	COG1678	Uncharacterized ACR, COG1678
VCA1004_RS08860	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
VCA1004_RS08880	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
VCA1004_RS08885	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
VCA1004_RS08890	COG0762	integral membrane protein
VCA1004_RS08895	COG1872	DUF167
VCA1004_RS08905	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
VCA1004_RS08910	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VCA1004_RS08915	COG2066	Belongs to the glutaminase family
VCA1004_RS08990	COG1012	belongs to the aldehyde dehydrogenase family
VCA1004_RS09000	COG0463	Glycosyl transferase, family 2
VCA1004_RS09015	COG0795	lipopolysaccharide-transporting ATPase activity
VCA1004_RS09020	COG0795	lipopolysaccharide-transporting ATPase activity
VCA1004_RS09025	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VCA1004_RS09030	COG2927	DNA polymerase III (CHI subunit)
VCA1004_RS09035	COG0525	valine-tRNA ligase activity
VCA1004_RS09055	COG0456	acetyltransferase
VCA1004_RS09070	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
VCA1004_RS09080	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
VCA1004_RS09085	COG0251	oxidation-reduction process
VCA1004_RS09105	COG2814	Major facilitator Superfamily
VCA1004_RS09110	COG1566	PFAM secretion protein HlyD family protein
VCA1004_RS09115	COG1846	Transcriptional regulator
VCA1004_RS09120	COG0598	Magnesium transport protein CorA
VCA1004_RS09125	COG0204	Acyl-transferase
VCA1004_RS09135	COG5007	Belongs to the BolA IbaG family
VCA1004_RS09145	COG2854	intermembrane phospholipid transfer
VCA1004_RS09150	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VCA1004_RS09155	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
VCA1004_RS09160	COG1127	ABC transporter
VCA1004_RS09170	COG0517	IMP dehydrogenase activity
VCA1004_RS09170	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
VCA1004_RS09175	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
VCA1004_RS09185	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
VCA1004_RS09190	COG1137	ATPase activity
VCA1004_RS09205	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VCA1004_RS09210	COG1660	Displays ATPase and GTPase activities
VCA1004_RS09215	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VCA1004_RS09220	COG2239	Acts as a magnesium transporter
VCA1004_RS09225	COG0312	modulator of DNA gyrase
VCA1004_RS09230	COG3028	Belongs to the UPF0307 family
VCA1004_RS09235	COG0312	modulator of DNA gyrase
VCA1004_RS09240	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VCA1004_RS09255	COG0424	maF-like protein
VCA1004_RS09260	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
VCA1004_RS09265	COG1792	Involved in formation and maintenance of cell shape
VCA1004_RS09270	COG1077	Cell shape determining protein MreB Mrl
VCA1004_RS09320	COG1459	type II secretion system
VCA1004_RS09325	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VCA1004_RS09335	COG3409	Peptidoglycan-binding domain 1 protein
VCA1004_RS09335	COG3267	Type II secretory pathway component ExeA
VCA1004_RS09360	COG2199	diguanylate cyclase activity
VCA1004_RS09360	COG2200	EAL domain
VCA1004_RS09365	COG0629	single-stranded DNA binding
VCA1004_RS09370	COG2197	response regulator
VCA1004_RS09380	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
VCA1004_RS09390	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
VCA1004_RS09395	COG0527	aspartate kinase activity
VCA1004_RS09400	COG1410	methionine synthase
VCA1004_RS09400	COG0646	methionine synthase
VCA1004_RS09410	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VCA1004_RS09415	COG0739	heme binding
VCA1004_RS09420	COG0316	Belongs to the HesB IscA family
VCA1004_RS09430	COG0628	permease
VCA1004_RS09445	COG0747	negative chemotaxis
VCA1004_RS09455	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VCA1004_RS09460	COG0444	Belongs to the ABC transporter superfamily
VCA1004_RS09465	COG4608	Belongs to the ABC transporter superfamily
VCA1004_RS09475	COG2971	BadF BadG BcrA BcrD
VCA1004_RS09490	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VCA1004_RS09495	COG2814	Major facilitator Superfamily
VCA1004_RS09500	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VCA1004_RS09505	COG1643	Atp-dependent helicase
VCA1004_RS09515	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
VCA1004_RS09520	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VCA1004_RS09530	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VCA1004_RS09545	COG0842	Transport permease protein
VCA1004_RS09550	COG1131	(ABC) transporter
VCA1004_RS09555	COG0288	reversible hydration of carbon dioxide
VCA1004_RS09570	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VCA1004_RS09575	COG0508	dehydrogenase complex catalyzes the overall conversion of
VCA1004_RS09580	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
VCA1004_RS09585	COG2186	Transcriptional regulator
VCA1004_RS09595	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
VCA1004_RS09600	COG1757	Na H antiporter
VCA1004_RS09610	COG0157	Belongs to the NadC ModD family
VCA1004_RS09620	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VCA1004_RS09625	COG1459	type II secretion system
VCA1004_RS09635	COG0237	dephospho-CoA kinase activity
VCA1004_RS09640	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
VCA1004_RS09650	COG0494	nUDIX hydrolase
VCA1004_RS09655	COG0653	protein targeting
VCA1004_RS09665	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
VCA1004_RS09670	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
VCA1004_RS09675	COG0849	cell division
VCA1004_RS09680	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
VCA1004_RS09685	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VCA1004_RS09690	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
VCA1004_RS09695	COG0772	Belongs to the SEDS family
VCA1004_RS09700	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
VCA1004_RS09705	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VCA1004_RS09710	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
VCA1004_RS09715	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
VCA1004_RS09720	COG0768	penicillin binding
VCA1004_RS09725	COG3116	cell division
VCA1004_RS09730	COG0275	rRNA processing
VCA1004_RS09740	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
VCA1004_RS09745	COG3107	peptidoglycan biosynthetic process
VCA1004_RS09750	COG0792	nuclease activity
VCA1004_RS09755	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VCA1004_RS09760	COG2823	Periplasmic or secreted lipoprotein
VCA1004_RS09775	COG1840	ABC-type Fe3 transport system, periplasmic component
VCA1004_RS09780	COG0004	ammonium transporteR
VCA1004_RS09785	COG0347	Belongs to the P(II) protein family
VCA1004_RS09790	COG3112	Uncharacterised protein family (UPF0231)
VCA1004_RS09820	COG0175	sulfate reduction
VCA1004_RS09825	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VCA1004_RS09830	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VCA1004_RS09850	COG0735	belongs to the Fur family
VCA1004_RS09855	COG0166	Belongs to the GPI family
VCA1004_RS09865	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VCA1004_RS09880	COG0359	binds to the 23S rRNA
VCA1004_RS09890	COG2965	DNA replication, synthesis of RNA primer
VCA1004_RS09900	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VCA1004_RS09905	COG0557	exoribonuclease II activity
VCA1004_RS09915	COG1017	nitric oxide dioxygenase activity
VCA1004_RS09915	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VCA1004_RS09920	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
VCA1004_RS09925	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
VCA1004_RS09930	COG0330	HflC and HflK could
VCA1004_RS09935	COG0330	HflC and HflK could
VCA1004_RS09940	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
VCA1004_RS09950	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
VCA1004_RS09955	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
VCA1004_RS09965	COG0802	atpase or kinase
VCA1004_RS09970	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
VCA1004_RS10010	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
VCA1004_RS10015	COG1162	GTPase activity
VCA1004_RS10020	COG0688	phosphatidylethanolamine metabolic process
VCA1004_RS10035	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
VCA1004_RS10040	COG1053	succinate dehydrogenase
VCA1004_RS10045	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
VCA1004_RS10050	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
VCA1004_RS10065	COG1509	lysine 2,3-aminomutase activity
VCA1004_RS10075	COG3477	response to acidic pH
VCA1004_RS10080	COG0604	alcohol dehydrogenase
VCA1004_RS10085	COG1285	pathogenesis
VCA1004_RS10090	COG1119	ATPase activity
VCA1004_RS10095	COG0459	protein refolding
VCA1004_RS10105	COG0534	Mate efflux family protein
VCA1004_RS10110	COG1045	serine acetyltransferase
VCA1004_RS10115	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
VCA1004_RS10120	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
VCA1004_RS10125	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VCA1004_RS10130	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
VCA1004_RS10135	COG4942	peptidase
VCA1004_RS10140	COG3706	GGDEF domain
VCA1004_RS10170	COG1012	belongs to the aldehyde dehydrogenase family
VCA1004_RS10170	COG1454	alcohol dehydrogenase
VCA1004_RS10185	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VCA1004_RS10200	COG0154	amidase activity
VCA1004_RS10215	COG1216	Glycosyl transferase, family 2
VCA1004_RS10255	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
VCA1004_RS10280	COG1560	Kdo2-lipid A biosynthetic process
VCA1004_RS10290	COG0438	transferase activity, transferring glycosyl groups
VCA1004_RS10300	COG0859	PFAM glycosyl transferase family 9
VCA1004_RS10305	COG1519	Transferase
VCA1004_RS10320	COG3083	sulfuric ester hydrolase activity
VCA1004_RS10325	COG3642	lipopolysaccharide core region biosynthetic process
VCA1004_RS10330	COG0859	PFAM glycosyl transferase family 9
VCA1004_RS10335	COG0463	Glycosyl transferase, family 2
VCA1004_RS10345	COG0438	transferase activity, transferring glycosyl groups
VCA1004_RS10350	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
VCA1004_RS10355	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
VCA1004_RS10360	COG0267	Belongs to the bacterial ribosomal protein bL33 family
VCA1004_RS10365	COG0227	Belongs to the bacterial ribosomal protein bL28 family
VCA1004_RS10375	COG2003	Belongs to the UPF0758 family
VCA1004_RS10380	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
VCA1004_RS10385	COG0756	dUTP diphosphatase activity
VCA1004_RS10390	COG1309	transcriptional regulator
VCA1004_RS10395	COG1560	Kdo2-lipid A biosynthetic process
VCA1004_RS10400	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
VCA1004_RS10405	COG2233	PERMEase
VCA1004_RS10420	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VCA1004_RS10425	COG2183	response to ionizing radiation
VCA1004_RS10430	COG2271	Major facilitator Superfamily
VCA1004_RS10435	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
VCA1004_RS10440	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
VCA1004_RS10445	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
VCA1004_RS10450	COG1349	DNA-binding transcription factor activity
VCA1004_RS10455	COG0596	Alpha beta hydrolase
VCA1004_RS10470	COG1218	3'(2'),5'-bisphosphate nucleotidase
VCA1004_RS10475	COG0494	nUDIX hydrolase
VCA1004_RS10485	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VCA1004_RS10490	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VCA1004_RS10495	COG3156	type II secretion system protein K
VCA1004_RS10500	COG4795	General secretion pathway protein
VCA1004_RS10505	COG2165	general secretion pathway protein
VCA1004_RS10510	COG2165	general secretion pathway protein
VCA1004_RS10520	COG2165	general secretion pathway protein
VCA1004_RS10525	COG1459	type II secretion system
VCA1004_RS10530	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VCA1004_RS10540	COG3031	protein transport across the cell outer membrane
VCA1004_RS10545	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
VCA1004_RS10550	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
VCA1004_RS10565	COG0456	acetyltransferase
VCA1004_RS10580	COG1217	gtp-binding protein TYPA
VCA1004_RS10585	COG0174	glutamine synthetase
VCA1004_RS10595	COG3852	Histidine kinase
VCA1004_RS10605	COG5001	Diguanylate cyclase
VCA1004_RS10620	COG3078	GTPase activator activity
VCA1004_RS10635	COG0218	Necessary for normal cell division and for the maintenance of normal septation
VCA1004_RS10640	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VCA1004_RS10640	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VCA1004_RS10645	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
VCA1004_RS10655	COG0514	ATP-dependent DNA helicase (RecQ)
VCA1004_RS10660	COG2962	Rard protein
VCA1004_RS10670	COG3678	ATP-independent chaperone mediated protein folding
VCA1004_RS10675	COG0745	RESPONSE REGULATOR receiver
VCA1004_RS10680	COG2205	protein histidine kinase activity
VCA1004_RS10685	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
VCA1004_RS10690	COG3030	protein affecting phage T7 exclusion by the F plasmid
VCA1004_RS10695	COG1027	Aspartate ammonia-lyase
VCA1004_RS10700	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VCA1004_RS10705	COG4232	protein-disulfide reductase activity
VCA1004_RS10715	COG3263	regulation of cellular component size
VCA1004_RS10720	COG2095	MarC family integral membrane protein
VCA1004_RS10730	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VCA1004_RS10740	COG2202	Pas domain
VCA1004_RS10740	COG2205	protein histidine kinase activity
VCA1004_RS10745	COG2814	Major facilitator Superfamily
VCA1004_RS10760	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VCA1004_RS10770	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
VCA1004_RS10775	COG0511	ligase activity, forming carbon-carbon bonds
VCA1004_RS10780	COG0439	Biotin carboxylase
VCA1004_RS10795	COG3181	Tripartite tricarboxylate transporter family receptor
VCA1004_RS10805	COG3924	membrane
VCA1004_RS10810	COG4145	pantothenate transmembrane transporter activity
VCA1004_RS10815	COG2264	protein methyltransferase activity
VCA1004_RS10825	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
VCA1004_RS10845	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
VCA1004_RS10855	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
VCA1004_RS10860	COG1263	PTS System
VCA1004_RS10860	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VCA1004_RS10865	COG1609	Transcriptional regulator
VCA1004_RS10875	COG0138	bifunctional purine biosynthesis protein purh
VCA1004_RS10880	COG0151	Belongs to the GarS family
VCA1004_RS10900	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VCA1004_RS10905	COG1573	uracil-dna glycosylase
VCA1004_RS10920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VCA1004_RS10935	COG2816	NAD+ diphosphatase activity
VCA1004_RS10940	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
VCA1004_RS10950	COG2801	Transposase and inactivated derivatives
VCA1004_RS10955	COG2963	transposase activity
VCA1004_RS10965	COG0085	RNA polymerase activity
VCA1004_RS10975	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
VCA1004_RS10990	COG0250	Participates in transcription elongation, termination and antitermination
VCA1004_RS10995	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VCA1004_RS11025	COG1072	(Pantothenic acid kinase))
VCA1004_RS11035	COG0812	UDP-N-acetylmuramate dehydrogenase activity
VCA1004_RS11045	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VCA1004_RS11080	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
VCA1004_RS11100	COG0009	L-threonylcarbamoyladenylate synthase
VCA1004_RS11105	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
VCA1004_RS11110	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
VCA1004_RS11115	COG0551	DNA topoisomerase type I activity
VCA1004_RS11120	COG2922	Belongs to the Smg family
VCA1004_RS11125	COG0758	DNA mediated transformation
VCA1004_RS11135	COG0242	peptide deformylase activity
VCA1004_RS11145	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VCA1004_RS11145	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VCA1004_RS11150	COG0569	domain protein
VCA1004_RS11155	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VCA1004_RS11160	COG1272	protein, Hemolysin III
VCA1004_RS11170	COG3084	Protein conserved in bacteria
VCA1004_RS11180	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
VCA1004_RS11185	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VCA1004_RS11190	COG0204	Acyl-transferase
VCA1004_RS11195	COG0606	chelatase, subunit chli
VCA1004_RS11205	COG3978	acetolactate synthase activity
VCA1004_RS11225	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
VCA1004_RS11230	COG0583	DNA-binding transcription factor activity
VCA1004_RS11235	COG2814	Major facilitator Superfamily
VCA1004_RS11245	COG0355	proton-transporting ATP synthase activity, rotational mechanism
VCA1004_RS11250	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
VCA1004_RS11255	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
VCA1004_RS11260	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
VCA1004_RS11270	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
VCA1004_RS11280	COG0356	it plays a direct role in the translocation of protons across the membrane
VCA1004_RS11290	COG1475	DNA binding
VCA1004_RS11295	COG1192	Involved in chromosome partitioning
VCA1004_RS11300	COG0357	Ribosomal RNA small subunit methyltransferase G
VCA1004_RS11305	COG0445	tRNA wobble uridine modification
VCA1004_RS11345	COG0534	Mate efflux family protein
VCA1004_RS11355	COG1966	Carbon starvation protein
VCA1004_RS11365	COG0003	Pfam Anion-transporting ATPase
VCA1004_RS11375	COG0477	Major facilitator Superfamily
VCA1004_RS11380	COG0786	glutamate:sodium symporter activity
VCA1004_RS11390	COG1434	Gram-negative-bacterium-type cell wall biogenesis
VCA1004_RS11395	COG4948	Mandelate Racemase Muconate Lactonizing
VCA1004_RS11450	COG4771	TonB-dependent receptor
VCA1004_RS11455	COG0583	DNA-binding transcription factor activity
VCA1004_RS11460	COG4604	ABC transporter, ATP-binding protein
VCA1004_RS11465	COG4605	iron ion homeostasis
VCA1004_RS11470	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VCA1004_RS11480	COG1846	Transcriptional regulator
VCA1004_RS11485	COG1764	response to oxidative stress
VCA1004_RS11510	COG1464	Belongs to the NlpA lipoprotein family
VCA1004_RS11515	COG0488	(ABC) transporter
VCA1004_RS11520	COG2814	Major facilitator Superfamily
VCA1004_RS11525	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VCA1004_RS11530	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VCA1004_RS11545	COG0583	DNA-binding transcription factor activity
VCA1004_RS11550	COG2814	Major facilitator Superfamily
VCA1004_RS11560	COG2814	Major facilitator Superfamily
VCA1004_RS11575	COG0110	maltose O-acetyltransferase activity
VCA1004_RS11580	COG0564	pseudouridine synthase activity
VCA1004_RS11590	COG1518	maintenance of DNA repeat elements
VCA1004_RS11595	COG1203	CRISPR-associated helicase, Cas3
VCA1004_RS11620	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
VCA1004_RS11620	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
VCA1004_RS11625	COG0509	glycine decarboxylation via glycine cleavage system
VCA1004_RS11635	COG1115	amino acid carrier protein
VCA1004_RS11640	COG0404	The glycine cleavage system catalyzes the degradation of glycine
VCA1004_RS11655	COG2824	Alkylphosphonate utilization operon protein PhnA
VCA1004_RS11665	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VCA1004_RS11665	COG2190	(PTS) system
VCA1004_RS11665	COG1263	PTS System
VCA1004_RS11670	COG2723	6-phospho-beta-galactosidase activity
VCA1004_RS11675	COG1609	Transcriptional regulator
VCA1004_RS11680	COG1011	Hydrolase
VCA1004_RS11685	COG1846	Transcriptional regulator
VCA1004_RS11690	COG2113	Glycine betaine
VCA1004_RS11695	COG2113	Glycine betaine
VCA1004_RS11700	COG4176	ABC-type proline glycine betaine transport system permease component
VCA1004_RS11715	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VCA1004_RS11720	COG0418	dihydroorotase activity
VCA1004_RS11725	COG0633	Ferredoxin
VCA1004_RS11725	COG3217	Mosc domain protein beta barrel domain protein
VCA1004_RS11730	COG0561	phosphatase activity
VCA1004_RS11755	COG0235	Class ii aldolase
VCA1004_RS11760	COG1070	Carbohydrate kinase
VCA1004_RS11765	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
VCA1004_RS11770	COG1349	DNA-binding transcription factor activity
VCA1004_RS11790	COG0513	Belongs to the DEAD box helicase family
VCA1004_RS11800	COG0583	DNA-binding transcription factor activity
VCA1004_RS11815	COG0583	DNA-binding transcription factor activity
VCA1004_RS11820	COG3384	dioxygenase
VCA1004_RS11825	COG2259	Doxx family
VCA1004_RS11830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VCA1004_RS11835	COG2801	Transposase and inactivated derivatives
VCA1004_RS11840	COG2963	transposase activity
VCA1004_RS11850	COG3842	ATPase activity
VCA1004_RS11880	COG0583	DNA-binding transcription factor activity
VCA1004_RS11885	COG0730	response to heat
VCA1004_RS11890	COG2200	EAL domain
VCA1004_RS11905	COG0583	DNA-binding transcription factor activity
VCA1004_RS11920	COG3722	fumarate hydratase activity
VCA1004_RS11930	COG2213	PTS system mannitol-specific
VCA1004_RS11930	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
VCA1004_RS11935	COG1741	Belongs to the pirin family
VCA1004_RS11950	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VCA1004_RS11970	COG1067	ATP-dependent peptidase activity
VCA1004_RS11980	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VCA1004_RS11980	COG2221	Nitrite and sulphite reductase 4Fe-4S
VCA1004_RS11985	COG3381	protein complex oligomerization
VCA1004_RS11990	COG0243	molybdopterin cofactor binding
VCA1004_RS11995	COG0437	4 iron, 4 sulfur cluster binding
VCA1004_RS12000	COG3302	dmso reductase anchor subunit
VCA1004_RS12005	COG4667	esterase of the alpha-beta hydrolase superfamily
VCA1004_RS12015	COG1757	Na H antiporter
VCA1004_RS12020	COG2354	Protein conserved in bacteria
VCA1004_RS12040	COG4681	YaeQ
VCA1004_RS12045	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
VCA1004_RS12060	COG5413	integral membrane protein
VCA1004_RS12075	COG0737	Belongs to the 5'-nucleotidase family
VCA1004_RS12080	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VCA1004_RS12085	COG1085	galactose-1-phosphate uridylyltransferase
VCA1004_RS12090	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
VCA1004_RS12095	COG2017	converts alpha-aldose to the beta-anomer
VCA1004_RS12100	COG2814	Major facilitator Superfamily
VCA1004_RS12105	COG0671	phosphoesterase, PA-phosphatase related
VCA1004_RS12120	COG2304	oxidoreductase activity
VCA1004_RS12140	COG0714	Associated with various cellular activities
VCA1004_RS12150	COG3530	Putative quorum-sensing-regulated virulence factor
VCA1004_RS12155	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
VCA1004_RS12180	COG0247	lactate metabolic process
VCA1004_RS12180	COG0277	FAD linked oxidase domain protein
VCA1004_RS12185	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VCA1004_RS12200	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
VCA1004_RS12210	COG0291	Belongs to the bacterial ribosomal protein bL35 family
VCA1004_RS12215	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
VCA1004_RS12220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VCA1004_RS12225	COG0577	efflux transmembrane transporter activity
VCA1004_RS12225	COG1136	(ABC) transporter
VCA1004_RS12230	COG1538	Outer membrane efflux protein
VCA1004_RS12250	COG4993	Dehydrogenase
VCA1004_RS12270	COG3138	arginine N-succinyltransferase
VCA1004_RS12275	COG1012	belongs to the aldehyde dehydrogenase family
VCA1004_RS12280	COG3724	N-succinylarginine dihydrolase activity
VCA1004_RS12305	COG0516	GMP reductase activity
VCA1004_RS12310	COG0640	Transcriptional regulator
VCA1004_RS12315	COG0798	PFAM Bile acid sodium symporter
VCA1004_RS12320	COG0583	DNA-binding transcription factor activity
VCA1004_RS12330	COG1346	cytolysis
VCA1004_RS12355	COG2207	Transcriptional regulator
VCA1004_RS12360	COG0402	S-adenosylhomocysteine deaminase activity
VCA1004_RS12365	COG0477	Major facilitator Superfamily
VCA1004_RS12375	COG0745	RESPONSE REGULATOR receiver
VCA1004_RS12380	COG2205	protein histidine kinase activity
VCA1004_RS12380	COG2770	Histidine kinase
VCA1004_RS12390	COG3314	Sporulation integral membrane protein YlbJ
VCA1004_RS12395	COG0513	Belongs to the DEAD box helicase family
VCA1004_RS12440	COG0366	Alpha amylase catalytic
VCA1004_RS12445	COG4580	involved in the transport of maltose and maltodextrins
VCA1004_RS12455	COG1053	succinate dehydrogenase
VCA1004_RS12465	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VCA1004_RS12470	COG2205	protein histidine kinase activity
VCA1004_RS12475	COG0745	RESPONSE REGULATOR receiver
VCA1004_RS12485	COG3842	ATPase activity
VCA1004_RS12490	COG2182	Extracellular solute-binding protein
VCA1004_RS12495	COG1175	transmembrane transport
VCA1004_RS12500	COG3833	ABC-type maltose transport systems, permease component
VCA1004_RS12525	COG0656	L-ascorbic acid biosynthetic process
VCA1004_RS12535	COG1902	pentaerythritol trinitrate reductase activity
VCA1004_RS12540	COG0583	DNA-binding transcription factor activity
VCA1004_RS12550	COG0405	Gamma-glutamyltransferase
VCA1004_RS12565	COG1640	4-alpha-glucanotransferase
VCA1004_RS12570	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VCA1004_RS12575	COG0574	Belongs to the PEP-utilizing enzyme family
VCA1004_RS12575	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
VCA1004_RS12580	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
VCA1004_RS12595	COG0583	DNA-binding transcription factor activity
VCA1004_RS12600	COG0569	domain protein
VCA1004_RS12605	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VCA1004_RS12610	COG3304	Inner membrane component domain
VCA1004_RS12615	COG1765	OsmC-like protein
VCA1004_RS12655	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
VCA1004_RS12670	COG1063	alcohol dehydrogenase
VCA1004_RS12685	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
VCA1004_RS12700	COG2186	Transcriptional regulator
VCA1004_RS12710	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
VCA1004_RS12715	COG3960	tartronate-semialdehyde synthase activity
VCA1004_RS12720	COG3622	Belongs to the hyi family
VCA1004_RS12725	COG2084	Dehydrogenase
VCA1004_RS12740	COG1597	lipid kinase activity
VCA1004_RS12745	COG0814	amino acid
VCA1004_RS12765	COG0402	S-adenosylhomocysteine deaminase activity
VCA1004_RS12790	COG0516	GMP reductase activity
VCA1004_RS12790	COG0517	IMP dehydrogenase activity
VCA1004_RS12815	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
VCA1004_RS12820	COG1984	allophanate hydrolase subunit 2
VCA1004_RS12825	COG1289	transmembrane transporter activity
VCA1004_RS12830	COG0210	DNA helicase
VCA1004_RS12850	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VCA1004_RS12855	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VCA1004_RS12865	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VCA1004_RS12870	COG3119	arylsulfatase activity
VCA1004_RS12875	COG0714	Associated with various cellular activities
VCA1004_RS12895	COG2304	oxidoreductase activity
VCA1004_RS12905	COG0583	DNA-binding transcription factor activity
VCA1004_RS12915	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VCA1004_RS12925	COG5001	Diguanylate cyclase
VCA1004_RS12925	COG3300	MHYT domain
VCA1004_RS12940	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VCA1004_RS12945	COG0456	acetyltransferase
VCA1004_RS12960	COG1278	Cold shock
VCA1004_RS12965	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VCA1004_RS12970	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
VCA1004_RS12975	COG1609	Transcriptional regulator
VCA1004_RS12980	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VCA1004_RS12985	COG1879	ABC-type sugar transport system periplasmic component
VCA1004_RS12990	COG1172	Belongs to the binding-protein-dependent transport system permease family
VCA1004_RS12995	COG1129	ABC transporter
VCA1004_RS13000	COG1869	D-ribose catabolic process
VCA1004_RS13015	COG1451	nucleotide metabolic process
VCA1004_RS13025	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VCA1004_RS13035	COG4181	ATPase activity
VCA1004_RS13040	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
VCA1004_RS13045	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
VCA1004_RS13055	COG1328	CTP reductase activity
VCA1004_RS13060	COG0602	queuosine metabolic process
VCA1004_RS13070	COG4067	protein conserved in archaea
VCA1004_RS13070	COG0189	ligase activity
VCA1004_RS13075	COG1492	cobalamin metabolic process
VCA1004_RS13080	COG2005	Transcriptional regulator
VCA1004_RS13080	COG3585	molybdate ion transport
VCA1004_RS13085	COG0725	ABC transporter, periplasmic molybdate-binding protein
VCA1004_RS13090	COG4149	molybdate abc transporter
VCA1004_RS13095	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
VCA1004_RS13100	COG3769	mannosylglycerate metabolic process
VCA1004_RS13105	COG1215	transferase activity, transferring glycosyl groups
VCA1004_RS13110	COG0366	Alpha amylase catalytic
VCA1004_RS13135	COG0521	Mo-molybdopterin cofactor biosynthetic process
VCA1004_RS13155	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
VCA1004_RS13170	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
VCA1004_RS13175	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
VCA1004_RS13195	COG3140	Belongs to the UPF0181 family
VCA1004_RS13200	COG0583	DNA-binding transcription factor activity
VCA1004_RS13205	COG3085	chromosome segregation
VCA1004_RS13250	COG3278	Belongs to the heme-copper respiratory oxidase family
VCA1004_RS13265	COG2010	Cytochrome c
VCA1004_RS13275	COG2217	Heavy metal translocating P-type atpase
VCA1004_RS13290	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VCA1004_RS13295	COG0589	response to stress
VCA1004_RS13300	COG0037	tRNA processing
VCA1004_RS13320	COG3842	ATPase activity
VCA1004_RS13330	COG1177	transmembrane transport
VCA1004_RS13340	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
VCA1004_RS13360	COG1940	carbohydrate kinase activity
VCA1004_RS13365	COG0791	NLP P60 protein
VCA1004_RS13380	COG0534	Mate efflux family protein
VCA1004_RS13385	COG1793	dna ligase
VCA1004_RS13390	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VCA1004_RS13395	COG0746	molybdenum cofactor guanylyltransferase activity
VCA1004_RS13400	COG1763	Mo-molybdopterin cofactor biosynthetic process
VCA1004_RS13430	COG0456	acetyltransferase
VCA1004_RS13440	COG1301	dicarboxylic acid transport
VCA1004_RS13450	COG0352	thiamine-phosphate diphosphorylase activity
VCA1004_RS13455	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
VCA1004_RS13460	COG0351	phosphomethylpyrimidine kinase
VCA1004_RS13480	COG0625	glutathione transferase activity
VCA1004_RS13490	COG3122	Protein conserved in bacteria
VCA1004_RS13505	COG0513	Belongs to the DEAD box helicase family
VCA1004_RS13520	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VCA1004_RS13525	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VCA1004_RS13530	COG0583	DNA-binding transcription factor activity
VCA1004_RS13545	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
VCA1004_RS13550	COG4139	cobalamin transport
VCA1004_RS13560	COG1648	precorrin-2 dehydrogenase activity
VCA1004_RS13560	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VCA1004_RS13565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VCA1004_RS13570	COG4597	amino acid ABC transporter
VCA1004_RS13575	COG0765	amino acid transport
VCA1004_RS13580	COG1126	abc transporter atp-binding protein
VCA1004_RS13585	COG0670	Belongs to the BI1 family
VCA1004_RS13590	COG2920	part of a sulfur-relay system
VCA1004_RS13595	COG1254	Belongs to the acylphosphatase family
VCA1004_RS13600	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VCA1004_RS13625	COG1280	lysine exporter protein (LysE YggA)
VCA1004_RS13630	COG1823	symporter activity
VCA1004_RS13650	COG0443	Heat shock 70 kDa protein
VCA1004_RS13665	COG0179	Fumarylacetoacetate (FAA) hydrolase
VCA1004_RS13670	COG0419	ATPase involved in DNA repair
VCA1004_RS13675	COG0420	3'-5' exonuclease activity
VCA1004_RS13680	COG1462	curli production assembly transport component CsgG
VCA1004_RS13725	COG1803	Methylglyoxal synthase
VCA1004_RS13735	COG3119	arylsulfatase activity
VCA1004_RS13740	COG0641	radical SAM
VCA1004_RS13760	COG0523	cobalamin synthesis protein
VCA1004_RS13765	COG0038	chloride channel
VCA1004_RS13770	COG0004	ammonium transporteR
VCA1004_RS13790	COG2897	thiosulfate sulfurtransferase activity
VCA1004_RS13810	COG2814	Major facilitator Superfamily
VCA1004_RS13820	COG4989	oxidoreductase activity
VCA1004_RS13845	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VCA1004_RS13855	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
VCA1004_RS13875	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
VCA1004_RS13880	COG2186	Transcriptional regulator
VCA1004_RS13885	COG1802	Transcriptional regulator
VCA1004_RS13905	COG1917	Cupin 2, conserved barrel domain protein
VCA1004_RS13910	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VCA1004_RS13915	COG0800	Aldolase
VCA1004_RS13920	COG2186	Transcriptional regulator
VCA1004_RS13930	COG0246	Mannitol dehydrogenase
VCA1004_RS13935	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VCA1004_RS13945	COG1609	Transcriptional regulator
VCA1004_RS13950	COG4948	Mandelate Racemase Muconate Lactonizing
VCA1004_RS13965	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VCA1004_RS13970	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VCA1004_RS13985	COG2822	iron ion transport
VCA1004_RS13990	COG2837	iron assimilation
VCA1004_RS13995	COG0672	)-iron permease
VCA1004_RS14005	COG0583	DNA-binding transcription factor activity
VCA1004_RS14010	COG1028	Short-chain dehydrogenase reductase Sdr
VCA1004_RS14015	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
VCA1004_RS14020	COG2252	PERMEase
VCA1004_RS14025	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
VCA1004_RS14030	COG0583	DNA-binding transcription factor activity
VCA1004_RS14035	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VCA1004_RS14035	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VCA1004_RS14050	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
VCA1004_RS14055	COG0789	Transcriptional regulator
VCA1004_RS14065	COG2801	Transposase and inactivated derivatives
VCA1004_RS14070	COG2963	transposase activity
VCA1004_RS14075	COG0628	permease
VCA1004_RS14085	COG2814	Major facilitator Superfamily
VCA1004_RS14090	COG0243	molybdopterin cofactor binding
VCA1004_RS14095	COG3005	denitrification pathway
VCA1004_RS14110	COG1309	transcriptional regulator
VCA1004_RS14115	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VCA1004_RS14115	COG3711	transcriptional antiterminator
VCA1004_RS14130	COG3964	amidohydrolase
VCA1004_RS14180	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
VCA1004_RS14195	COG2351	hydroxyisourate hydrolase activity
VCA1004_RS14200	COG2252	PERMEase
VCA1004_RS14205	COG1609	Transcriptional regulator
VCA1004_RS14220	COG1126	abc transporter atp-binding protein
VCA1004_RS14225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VCA1004_RS14230	COG4215	(ABC) transporter
VCA1004_RS14235	COG4160	amino acid transport
VCA1004_RS14240	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
VCA1004_RS14245	COG4208	sulfate ABC transporter
VCA1004_RS14250	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
VCA1004_RS14265	COG0189	ligase activity
VCA1004_RS14265	COG4067	protein conserved in archaea
VCA1004_RS14270	COG0189	ligase activity
VCA1004_RS14280	COG3123	guanosine phosphorylase activity
VCA1004_RS14290	COG0531	amino acid
VCA1004_RS14300	COG4166	transmembrane transport
VCA1004_RS14320	COG1999	signal sequence binding
VCA1004_RS14350	COG0457	Tetratricopeptide repeat
VCA1004_RS14355	COG1215	transferase activity, transferring glycosyl groups
VCA1004_RS14360	COG1215	transferase activity, transferring glycosyl groups
VCA1004_RS14375	COG0527	aspartate kinase activity
VCA1004_RS14380	COG0662	Cupin 2, conserved barrel domain protein
VCA1004_RS14385	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
VCA1004_RS14390	COG0456	acetyltransferase
VCA1004_RS14395	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
VCA1004_RS14405	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
VCA1004_RS14425	COG1242	4 iron, 4 sulfur cluster binding
VCA1004_RS14435	COG1609	Transcriptional regulator
VCA1004_RS14435	COG2207	Transcriptional regulator
VCA1004_RS14440	COG1070	Carbohydrate kinase
VCA1004_RS14445	COG2814	Major facilitator Superfamily
VCA1004_RS14445	COG0477	Major facilitator Superfamily
VCA1004_RS14450	COG2115	Belongs to the xylose isomerase family
VCA1004_RS14455	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
VCA1004_RS14460	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
VCA1004_RS14470	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
VCA1004_RS14505	COG1714	RDD family
VCA1004_RS14515	COG1120	ATPase activity
VCA1004_RS14520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VCA1004_RS14525	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VCA1004_RS14535	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
VCA1004_RS14550	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VCA1004_RS14555	COG0640	Transcriptional regulator
VCA1004_RS14565	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
VCA1004_RS14570	COG0573	inorganic phosphate transmembrane transporter activity
VCA1004_RS14575	COG0581	inorganic phosphate transmembrane transporter activity
VCA1004_RS14605	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VCA1004_RS14610	COG0583	DNA-binding transcription factor activity
VCA1004_RS14620	COG0739	heme binding
VCA1004_RS14625	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
VCA1004_RS14630	COG0830	nickel cation binding
VCA1004_RS14640	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
VCA1004_RS14650	COG0804	urea catabolic process
VCA1004_RS14655	COG0832	Belongs to the urease beta subunit family
VCA1004_RS14660	COG0831	urea catabolic process
VCA1004_RS14665	COG0829	nickel cation binding
VCA1004_RS14670	COG1454	alcohol dehydrogenase
VCA1004_RS14675	COG0668	transmembrane transport
VCA1004_RS14690	COG4214	carbohydrate transport
VCA1004_RS14695	COG0559	Belongs to the binding-protein-dependent transport system permease family
VCA1004_RS14705	COG0583	DNA-binding transcription factor activity
VCA1004_RS14710	COG3257	ureidoglycine aminohydrolase activity
VCA1004_RS14715	COG5002	protein histidine kinase activity
VCA1004_RS14725	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
VCA1004_RS14730	COG2194	sulfuric ester hydrolase activity
VCA1004_RS14745	COG0573	inorganic phosphate transmembrane transporter activity
VCA1004_RS14755	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VCA1004_RS14765	COG0573	inorganic phosphate transmembrane transporter activity
VCA1004_RS14770	COG0581	inorganic phosphate transmembrane transporter activity
VCA1004_RS14775	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VCA1004_RS14780	COG2199	diguanylate cyclase activity
VCA1004_RS14785	COG0307	riboflavin synthase, alpha
VCA1004_RS14790	COG2197	response regulator
VCA1004_RS14795	COG3850	Histidine kinase
VCA1004_RS14800	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VCA1004_RS14810	COG0243	molybdopterin cofactor binding
VCA1004_RS14820	COG3005	denitrification pathway
VCA1004_RS14835	COG1609	Transcriptional regulator
VCA1004_RS14840	COG0800	Aldolase
VCA1004_RS14845	COG0129	dihydroxy-acid dehydratase activity
VCA1004_RS14850	COG3265	gluconokinase activity
VCA1004_RS14855	COG2610	gluconate transmembrane transporter activity
VCA1004_RS14860	COG4221	oxidoreductase activity
VCA1004_RS14870	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VCA1004_RS14875	COG2146	nitrite reductase [NAD(P)H] activity
VCA1004_RS14890	COG1648	precorrin-2 dehydrogenase activity
VCA1004_RS14890	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VCA1004_RS14900	COG2827	Endonuclease containing a URI domain
VCA1004_RS14905	COG3132	Protein of unknown function, DUF480
VCA1004_RS14910	COG2926	Belongs to the UPF0265 family
VCA1004_RS14915	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
VCA1004_RS14925	COG1609	Transcriptional regulator
VCA1004_RS14930	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
VCA1004_RS14930	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VCA1004_RS14935	COG1105	Belongs to the carbohydrate kinase PfkB family
VCA1004_RS14940	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
VCA1004_RS14940	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VCA1004_RS14940	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VCA1004_RS14945	COG0318	PFAM AMP-dependent synthetase and ligase
VCA1004_RS14955	COG0109	protoheme IX farnesyltransferase activity
VCA1004_RS14960	COG1612	heme a metabolic process
VCA1004_RS14980	COG1845	cytochrome c oxidase, subunit III
VCA1004_RS14985	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
VCA1004_RS14995	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
VCA1004_RS15005	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
VCA1004_RS15025	COG0625	glutathione transferase activity
VCA1004_RS15050	COG0697	spore germination
VCA1004_RS15055	COG1803	Methylglyoxal synthase
VCA1004_RS15055	COG1597	lipid kinase activity
VCA1004_RS15065	COG3842	ATPase activity
VCA1004_RS15070	COG1176	ABC-type spermidine putrescine transport system, permease component I
VCA1004_RS15075	COG1177	transmembrane transport
VCA1004_RS15080	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VCA1004_RS15090	COG1280	lysine exporter protein (LysE YggA)
VCA1004_RS15105	COG1278	Cold shock
VCA1004_RS15110	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VCA1004_RS15130	COG0259	pyridoxamine-phosphate oxidase activity
VCA1004_RS15135	COG1444	tRNA N-acetyltransferase activity