locus-tag	class	description
VS_RS00005	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VS_RS00020	COG0594	ribonuclease P activity
VS_RS00030	COG1126	abc transporter atp-binding protein
VS_RS00050	COG0592	DNA-directed DNA polymerase activity
VS_RS00060	COG0187	DNA topoisomerase II activity
VS_RS00070	COG3977	Valine--pyruvate aminotransferase
VS_RS00090	COG4964	Belongs to the GSP D family
VS_RS00145	COG2205	protein histidine kinase activity
VS_RS00165	COG2119	membrane
VS_RS00190	COG0604	alcohol dehydrogenase
VS_RS00195	COG0183	Belongs to the thiolase family
VS_RS00205	COG1739	Uncharacterized protein family UPF0029
VS_RS00210	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VS_RS00260	COG0583	DNA-binding transcription factor activity
VS_RS00270	COG2960	long-chain fatty acid transporting porin activity
VS_RS00275	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VS_RS00280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VS_RS00285	COG1309	transcriptional regulator
VS_RS00340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VS_RS00365	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VS_RS00370	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
VS_RS00380	COG1522	sequence-specific DNA binding
VS_RS00385	COG5002	protein histidine kinase activity
VS_RS00385	COG5001	Diguanylate cyclase
VS_RS00405	COG0589	response to stress
VS_RS00410	COG1528	Iron-storage protein
VS_RS00420	COG2081	HI0933 family
VS_RS00435	COG1322	Protein conserved in bacteria
VS_RS00440	COG2226	methyltransferase
VS_RS00445	COG3165	ubiquinone biosynthetic process from chorismate
VS_RS00460	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VS_RS00465	COG0805	protein transport
VS_RS00470	COG0084	hydrolase, TatD family'
VS_RS00485	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VS_RS00485	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VS_RS00495	COG0218	Necessary for normal cell division and for the maintenance of normal septation
VS_RS00535	COG3852	Histidine kinase
VS_RS00545	COG0174	glutamine synthetase
VS_RS00575	COG0456	acetyltransferase
VS_RS00595	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
VS_RS00600	COG3031	protein transport across the cell outer membrane
VS_RS00610	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VS_RS00615	COG1459	type II secretion system
VS_RS00620	COG2165	general secretion pathway protein
VS_RS00625	COG2165	general secretion pathway protein
VS_RS00630	COG2165	general secretion pathway protein
VS_RS00635	COG4795	General secretion pathway protein
VS_RS00640	COG3156	type II secretion system protein K
VS_RS00645	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VS_RS00650	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VS_RS00660	COG1218	3'(2'),5'-bisphosphate nucleotidase
VS_RS00665	COG0494	nUDIX hydrolase
VS_RS00670	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
VS_RS00670	COG0316	Belongs to the HesB IscA family
VS_RS00690	COG2183	response to ionizing radiation
VS_RS00695	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VS_RS00700	COG0745	RESPONSE REGULATOR receiver
VS_RS00710	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
VS_RS00715	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VS_RS00725	COG0194	GDP metabolic process
VS_RS00730	COG2252	PERMEase
VS_RS00745	COG1263	PTS System
VS_RS00745	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VS_RS00755	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
VS_RS00760	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VS_RS00770	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VS_RS00775	COG1454	alcohol dehydrogenase
VS_RS00785	COG0561	phosphatase activity
VS_RS00795	COG1278	Cold shock
VS_RS00800	COG1561	YicC-like family, N-terminal region
VS_RS00815	COG1560	Kdo2-lipid A biosynthetic process
VS_RS00825	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
VS_RS00860	COG0859	PFAM glycosyl transferase family 9
VS_RS00865	COG1519	Transferase
VS_RS00880	COG3642	lipopolysaccharide core region biosynthetic process
VS_RS00890	COG0859	PFAM glycosyl transferase family 9
VS_RS00905	COG0438	transferase activity, transferring glycosyl groups
VS_RS00905	COG4641	Protein conserved in bacteria
VS_RS00915	COG1560	Kdo2-lipid A biosynthetic process
VS_RS00930	COG4942	peptidase
VS_RS00935	COG1045	serine acetyltransferase
VS_RS00950	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VS_RS00970	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VS_RS00975	COG1596	polysaccharide export
VS_RS00985	COG3206	protein involved in exopolysaccharide biosynthesis
VS_RS00985	COG0489	protein tyrosine kinase activity
VS_RS00990	COG2877	3-deoxy-8-phosphooctulonate synthase activity
VS_RS00995	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
VS_RS01005	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
VS_RS01005	COG0517	IMP dehydrogenase activity
VS_RS01030	COG0110	maltose O-acetyltransferase activity
VS_RS01035	COG0438	transferase activity, transferring glycosyl groups
VS_RS01070	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VS_RS01085	COG0534	Mate efflux family protein
VS_RS01090	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
VS_RS01110	COG2203	Gaf domain
VS_RS01110	COG2199	diguanylate cyclase activity
VS_RS01115	COG1285	pathogenesis
VS_RS01120	COG1509	lysine 2,3-aminomutase activity
VS_RS01140	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
VS_RS01145	COG1053	succinate dehydrogenase
VS_RS01160	COG0840	transmembrane signaling receptor activity
VS_RS01165	COG0471	metal ion transport
VS_RS01165	COG0490	domain, Protein
VS_RS01180	COG1162	GTPase activity
VS_RS01225	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
VS_RS01230	COG0802	atpase or kinase
VS_RS01235	COG0860	N-Acetylmuramoyl-L-alanine amidase
VS_RS01240	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
VS_RS01255	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
VS_RS01260	COG0330	HflC and HflK could
VS_RS01265	COG0330	HflC and HflK could
VS_RS01270	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
VS_RS01275	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
VS_RS01280	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
VS_RS01285	COG0402	S-adenosylhomocysteine deaminase activity
VS_RS01290	COG0557	exoribonuclease II activity
VS_RS01295	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VS_RS01335	COG0432	Pfam Uncharacterised protein family UPF0047
VS_RS01350	COG0735	belongs to the Fur family
VS_RS01390	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VS_RS01445	COG0527	aspartate kinase activity
VS_RS01450	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
VS_RS01460	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
VS_RS01470	COG2197	response regulator
VS_RS01475	COG0629	single-stranded DNA binding
VS_RS01480	COG2200	EAL domain
VS_RS01480	COG2199	diguanylate cyclase activity
VS_RS01505	COG3409	Peptidoglycan-binding domain 1 protein
VS_RS01505	COG3267	Type II secretory pathway component ExeA
VS_RS01515	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VS_RS01520	COG1459	type II secretion system
VS_RS01565	COG1077	Cell shape determining protein MreB Mrl
VS_RS01570	COG1792	Involved in formation and maintenance of cell shape
VS_RS01575	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
VS_RS01580	COG0424	maF-like protein
VS_RS01585	COG1530	ribonuclease E activity
VS_RS01590	COG3164	Protein of unknown function
VS_RS01595	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VS_RS01600	COG0312	modulator of DNA gyrase
VS_RS01605	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
VS_RS01620	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VS_RS01625	COG0589	response to stress
VS_RS01655	COG0142	geranyltranstransferase activity
VS_RS01680	COG3610	response to peptide
VS_RS01705	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
VS_RS01710	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VS_RS01715	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
VS_RS01720	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
VS_RS01745	COG0473	3-isopropylmalate dehydrogenase activity
VS_RS01785	COG1022	Amp-dependent synthetase and ligase
VS_RS01790	COG0028	Belongs to the TPP enzyme family
VS_RS01815	COG0469	pyruvate kinase activity
VS_RS01820	COG1349	DNA-binding transcription factor activity
VS_RS01825	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
VS_RS01830	COG2873	o-acetylhomoserine
VS_RS01850	COG1610	YqeY-like protein
VS_RS01865	COG0596	Alpha beta hydrolase
VS_RS01875	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
VS_RS01880	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VS_RS01890	COG0617	tRNA 3'-terminal CCA addition
VS_RS01895	COG3267	Type II secretory pathway component ExeA
VS_RS01895	COG3409	Peptidoglycan-binding domain 1 protein
VS_RS01905	COG4991	sh3 domain protein
VS_RS01910	COG0306	phosphate transporter
VS_RS01915	COG1392	Phosphate transport regulator
VS_RS01920	COG3025	triphosphatase activity
VS_RS01925	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VS_RS01935	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
VS_RS01945	COG1538	Outer membrane efflux protein
VS_RS01950	COG0494	nUDIX hydrolase
VS_RS01955	COG3151	Protein conserved in bacteria
VS_RS01965	COG3150	esterase
VS_RS01980	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VS_RS01990	COG3105	Protein conserved in bacteria
VS_RS01995	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
VS_RS02010	COG0723	plastoquinol--plastocyanin reductase activity
VS_RS02015	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
VS_RS02020	COG2857	Cytochrome c1
VS_RS02025	COG0625	glutathione transferase activity
VS_RS02030	COG2969	positive regulation of protein catabolic process
VS_RS02035	COG2823	Periplasmic or secreted lipoprotein
VS_RS02040	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VS_RS02055	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
VS_RS02065	COG3116	cell division
VS_RS02070	COG0768	penicillin binding
VS_RS02075	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
VS_RS02080	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
VS_RS02095	COG0772	Belongs to the SEDS family
VS_RS02120	COG0849	cell division
VS_RS02125	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
VS_RS02150	COG0494	nUDIX hydrolase
VS_RS02160	COG0505	Belongs to the CarA family
VS_RS02165	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
VS_RS02170	COG0730	response to heat
VS_RS02175	COG0583	DNA-binding transcription factor activity
VS_RS02180	COG2860	membrane
VS_RS02185	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VS_RS02205	COG0493	'glutamate synthase
VS_RS02220	COG0070	glutamate synthase
VS_RS02220	COG0069	glutamate synthase activity
VS_RS02220	COG0067	glutamate synthase
VS_RS02225	COG1242	4 iron, 4 sulfur cluster binding
VS_RS02230	COG2203	Gaf domain
VS_RS02230	COG3706	GGDEF domain
VS_RS02230	COG4251	negative regulation of phosphorylation
VS_RS02230	COG5001	Diguanylate cyclase
VS_RS02235	COG0784	Response regulator, receiver
VS_RS02235	COG5002	protein histidine kinase activity
VS_RS02235	COG2198	Histidine kinase
VS_RS02245	COG0745	RESPONSE REGULATOR receiver
VS_RS02250	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VS_RS02270	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
VS_RS02305	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
VS_RS02310	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
VS_RS02325	COG1115	amino acid carrier protein
VS_RS02335	COG0513	Belongs to the DEAD box helicase family
VS_RS02360	COG4974	Belongs to the 'phage' integrase family
VS_RS02365	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VS_RS02370	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
VS_RS02415	COG0730	response to heat
VS_RS02430	COG0745	RESPONSE REGULATOR receiver
VS_RS02440	COG1283	sodium-dependent phosphate transmembrane transporter activity
VS_RS02445	COG0583	DNA-binding transcription factor activity
VS_RS02450	COG0640	Transcriptional regulator
VS_RS02460	COG0728	peptidoglycan biosynthetic process
VS_RS02465	COG0196	riboflavin kinase activity
VS_RS02480	COG1047	Peptidyl-prolyl cis-trans
VS_RS02485	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
VS_RS02490	COG3279	Response regulator of the LytR AlgR family
VS_RS02495	COG3275	phosphorelay sensor kinase activity
VS_RS02500	COG1966	Carbon starvation protein
VS_RS02515	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
VS_RS02525	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VS_RS02530	COG0287	Prephenate dehydrogenase
VS_RS02530	COG1605	Chorismate mutase
VS_RS02535	COG0739	heme binding
VS_RS02545	COG0488	(ABC) transporter
VS_RS02560	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
VS_RS02565	COG5001	Diguanylate cyclase
VS_RS02570	COG0077	Prephenate dehydratase
VS_RS02570	COG1605	Chorismate mutase
VS_RS02575	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VS_RS02580	COG0741	lytic transglycosylase activity
VS_RS02585	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VS_RS02590	COG0564	pseudouridine synthase activity
VS_RS02630	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
VS_RS02640	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VS_RS02655	COG0745	RESPONSE REGULATOR receiver
VS_RS02660	COG5002	protein histidine kinase activity
VS_RS02670	COG0248	Ppx GppA phosphatase
VS_RS02675	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
VS_RS02680	COG0573	inorganic phosphate transmembrane transporter activity
VS_RS02685	COG0581	inorganic phosphate transmembrane transporter activity
VS_RS02690	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VS_RS02695	COG0704	Plays a role in the regulation of phosphate uptake
VS_RS02720	COG0450	alkyl hydroperoxide reductase
VS_RS02725	COG0583	DNA-binding transcription factor activity
VS_RS02735	COG0517	IMP dehydrogenase activity
VS_RS02750	COG1862	Preprotein translocase
VS_RS02755	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VS_RS02760	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VS_RS02765	COG0483	inositol monophosphate 1-phosphatase activity
VS_RS02770	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
VS_RS02785	COG0822	iron-sulfur transferase activity
VS_RS02810	COG2975	iron-sulfur cluster assembly
VS_RS02830	COG1426	Protein conserved in bacteria
VS_RS02845	COG2976	Protein conserved in bacteria
VS_RS02850	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VS_RS02860	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
VS_RS02865	COG3706	GGDEF domain
VS_RS02875	COG1570	exodeoxyribonuclease VII activity
VS_RS02880	COG0517	IMP dehydrogenase activity
VS_RS02880	COG0516	GMP reductase activity
VS_RS02900	COG1584	GPR1 FUN34 yaaH family protein
VS_RS02905	COG1115	amino acid carrier protein
VS_RS02910	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
VS_RS02915	COG0204	Acyl-transferase
VS_RS02940	COG0189	ligase activity
VS_RS02940	COG4067	protein conserved in archaea
VS_RS02950	COG2867	negative regulation of translational initiation
VS_RS02955	COG2914	Belongs to the UPF0125 (RnfH) family
VS_RS02960	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VS_RS02965	COG0497	DNA recombination
VS_RS02980	COG1301	dicarboxylic acid transport
VS_RS03020	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
VS_RS03025	COG1253	flavin adenine dinucleotide binding
VS_RS03045	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
VS_RS03045	COG0047	phosphoribosylformylglycinamidine synthase activity
VS_RS03055	COG2171	N-acyltransferase activity
VS_RS03060	COG2095	MarC family integral membrane protein
VS_RS03075	COG3141	response to X-ray
VS_RS03090	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
VS_RS03095	COG1074	ATP-dependent DNA helicase activity
VS_RS03100	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
VS_RS03115	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
VS_RS03120	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
VS_RS03125	COG2166	iron-sulfur cluster assembly
VS_RS03130	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VS_RS03135	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
VS_RS03140	COG3248	Nucleoside-binding outer membrane protein
VS_RS03155	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VS_RS03170	COG0271	Belongs to the BolA IbaG family
VS_RS03180	COG1805	sodium ion transport
VS_RS03200	COG2871	sodium ion transport
VS_RS03205	COG1477	protein flavinylation
VS_RS03210	COG2991	Protein conserved in bacteria
VS_RS03220	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
VS_RS03230	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VS_RS03240	COG0733	neurotransmitter:sodium symporter activity
VS_RS03260	COG1686	Belongs to the peptidase S11 family
VS_RS03265	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
VS_RS03270	COG0772	Belongs to the SEDS family
VS_RS03275	COG0768	penicillin binding
VS_RS03285	COG0799	negative regulation of ribosome biogenesis
VS_RS03290	COG1466	dna polymerase III delta subunit
VS_RS03295	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
VS_RS03305	COG2888	peptidyl-tyrosine sulfation
VS_RS03310	COG0815	Transfers the fatty acyl group on membrane lipoproteins
VS_RS03315	COG4535	Mg2 and Co2 transporter CorC
VS_RS03325	COG1702	phosphate starvation-inducible protein PhoH
VS_RS03335	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VS_RS03340	COG2706	6-phosphogluconolactonase activity
VS_RS03430	COG0012	GTP binding
VS_RS03440	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
VS_RS03465	COG2890	protein-(glutamine-N5) methyltransferase activity
VS_RS03470	COG3094	Invasion gene expression up-regulator, SirB
VS_RS03475	COG2912	Transglutaminase-like superfamily
VS_RS03490	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
VS_RS03495	COG1187	pseudouridine synthase activity
VS_RS03500	COG2840	Smr protein MutS2
VS_RS03540	COG2217	Heavy metal translocating P-type atpase
VS_RS03540	COG2608	mercury ion transmembrane transporter activity
VS_RS03555	COG1028	Short-chain dehydrogenase reductase Sdr
VS_RS03590	COG2986	histidine ammonia-lyase
VS_RS03595	COG1216	Glycosyl transferase, family 2
VS_RS03615	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VS_RS03620	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VS_RS03680	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
VS_RS03685	COG0784	Response regulator, receiver
VS_RS03685	COG0835	chemotaxis
VS_RS03690	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
VS_RS03695	COG1815	bacterial-type flagellum-dependent cell motility
VS_RS03700	COG1558	bacterial-type flagellum-dependent cell motility
VS_RS03710	COG1749	Flagellar hook protein flgE
VS_RS03715	COG4787	bacterial-type flagellum-dependent cell motility
VS_RS03735	COG3951	Flagellar rod assembly protein muramidase FlgJ
VS_RS03735	COG1705	Flagellar rod assembly protein muramidase FlgJ
VS_RS03755	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VS_RS03760	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VS_RS03770	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
VS_RS03780	COG1516	flagellar protein fliS
VS_RS03790	COG4191	Histidine kinase
VS_RS03800	COG1677	Flagellar hook-basal body complex protein FliE
VS_RS03810	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
VS_RS03860	COG1987	bacterial-type flagellum assembly
VS_RS03865	COG1684	flagellar biosynthetic protein fliR
VS_RS03905	COG0643	Histidine kinase
VS_RS03905	COG2198	Histidine kinase
VS_RS03905	COG0784	Response regulator, receiver
VS_RS03910	COG2201	protein-glutamate methylesterase activity
VS_RS03915	COG1192	Involved in chromosome partitioning
VS_RS03925	COG0835	chemotaxis
VS_RS03935	COG4133	protoheme IX ABC transporter activity
VS_RS03940	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VS_RS03945	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VS_RS03950	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VS_RS03960	COG1138	Cytochrome C-type biogenesis protein
VS_RS03965	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VS_RS03970	COG3088	subunit of a heme lyase
VS_RS03970	COG4235	cytochrome complex assembly
VS_RS03975	COG3088	subunit of a heme lyase
VS_RS03975	COG4235	cytochrome complex assembly
VS_RS03985	COG2067	long-chain fatty acid transport protein
VS_RS03990	COG2067	long-chain fatty acid transport protein
VS_RS04005	COG0183	Belongs to the thiolase family
VS_RS04010	COG1024	Enoyl-CoA hydratase
VS_RS04010	COG1250	3-hydroxyacyl-CoA dehydrogenase
VS_RS04020	COG2062	phosphohistidine phosphatase, SixA
VS_RS04025	COG2840	Smr protein MutS2
VS_RS04030	COG2890	protein-(glutamine-N5) methyltransferase activity
VS_RS04035	COG1280	lysine exporter protein (LysE YggA)
VS_RS04045	COG0745	RESPONSE REGULATOR receiver
VS_RS04060	COG1175	transmembrane transport
VS_RS04070	COG3842	ATPase activity
VS_RS04080	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
VS_RS04085	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
VS_RS04090	COG2894	cell division
VS_RS04105	COG2951	lytic endotransglycosylase activity
VS_RS04110	COG0583	DNA-binding transcription factor activity
VS_RS04115	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VS_RS04140	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
VS_RS04145	COG2860	membrane
VS_RS04150	COG3101	peptidyl-lysine hydroxylation
VS_RS04160	COG0431	NADPH-dependent FMN reductase
VS_RS04170	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VS_RS04180	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VS_RS04200	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
VS_RS04205	COG0285	dihydrofolate synthase activity
VS_RS04210	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
VS_RS04215	COG1286	toxin biosynthetic process
VS_RS04220	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
VS_RS04225	COG0583	DNA-binding transcription factor activity
VS_RS04230	COG0745	RESPONSE REGULATOR receiver
VS_RS04240	COG2832	Protein of unknown function (DUF454)
VS_RS04250	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
VS_RS04285	COG1785	Belongs to the alkaline phosphatase family
VS_RS04305	COG2226	methyltransferase
VS_RS04320	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VS_RS04325	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VS_RS04335	COG3139	Protein of unknown function (DUF1315)
VS_RS04340	COG0252	asparaginase activity
VS_RS04345	COG0616	signal peptide processing
VS_RS04350	COG1902	pentaerythritol trinitrate reductase activity
VS_RS04350	COG0446	pyridine nucleotide-disulphide oxidoreductase
VS_RS04355	COG0778	Nitroreductase
VS_RS04360	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VS_RS04375	COG0123	including yeast histone deacetylase and acetoin utilization protein
VS_RS04385	COG1959	2 iron, 2 sulfur cluster binding
VS_RS04400	COG3083	sulfuric ester hydrolase activity
VS_RS04425	COG1757	Na H antiporter
VS_RS04430	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VS_RS04435	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VS_RS04440	COG2095	MarC family integral membrane protein
VS_RS04445	COG1454	alcohol dehydrogenase
VS_RS04445	COG1012	belongs to the aldehyde dehydrogenase family
VS_RS04465	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
VS_RS04485	COG2056	Na+-H+ antiporter family
VS_RS04505	COG0346	lactoylglutathione lyase activity
VS_RS04510	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
VS_RS04550	COG0556	nucleotide-excision repair
VS_RS04555	COG2204	response regulator
VS_RS04560	COG2198	Histidine kinase
VS_RS04565	COG0391	Required for morphogenesis under gluconeogenic growth conditions
VS_RS04575	COG0521	Mo-molybdopterin cofactor biosynthetic process
VS_RS04585	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
VS_RS04590	COG0314	molybdopterin synthase activity
VS_RS04600	COG0601	transmembrane transport
VS_RS04605	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VS_RS04610	COG0444	Belongs to the ABC transporter superfamily
VS_RS04620	COG0435	Glutathione S-transferase
VS_RS04630	COG0280	phosphate acetyltransferase
VS_RS04630	COG0857	belongs to the CobB CobQ family
VS_RS04635	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
VS_RS04650	COG3706	GGDEF domain
VS_RS04655	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VS_RS04665	COG0653	protein targeting
VS_RS04680	COG2186	Transcriptional regulator
VS_RS04695	COG0489	protein tyrosine kinase activity
VS_RS04705	COG2982	Protein involved in outer membrane biogenesis
VS_RS04710	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
VS_RS04715	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VS_RS04720	COG0659	secondary active sulfate transmembrane transporter activity
VS_RS04725	COG1530	ribonuclease E activity
VS_RS04730	COG0564	pseudouridine synthase activity
VS_RS04740	COG1399	metal-binding, possibly nucleic acid-binding protein
VS_RS04755	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VS_RS04780	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VS_RS04785	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
VS_RS04790	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
VS_RS04800	COG0084	hydrolase, TatD family'
VS_RS04815	COG0733	neurotransmitter:sodium symporter activity
VS_RS04825	COG4667	esterase of the alpha-beta hydrolase superfamily
VS_RS04830	COG0469	pyruvate kinase activity
VS_RS04835	COG1940	carbohydrate kinase activity
VS_RS04840	COG0784	Response regulator, receiver
VS_RS04840	COG0835	chemotaxis
VS_RS04855	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
VS_RS04860	COG1028	Short-chain dehydrogenase reductase Sdr
VS_RS04865	COG0616	signal peptide processing
VS_RS04870	COG2719	SpoVR family
VS_RS04875	COG2718	Belongs to the UPF0229 family
VS_RS04880	COG2766	serine protein kinase
VS_RS04885	COG3713	MltA-interacting MipA family protein
VS_RS04895	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VS_RS04905	COG1882	Formate acetyltransferase
VS_RS04930	COG4160	amino acid transport
VS_RS04940	COG0708	Exodeoxyribonuclease III
VS_RS04945	COG1770	oligopeptidase
VS_RS04950	COG2814	Major facilitator Superfamily
VS_RS04960	COG2850	peptidyl-arginine hydroxylation
VS_RS04980	COG1199	ATP-dependent helicase activity
VS_RS05000	COG1278	Cold shock
VS_RS05010	COG0542	response to heat
VS_RS05015	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
VS_RS05020	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
VS_RS05045	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VS_RS05050	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
VS_RS05075	COG3070	regulator of competence-specific genes
VS_RS05090	COG0745	RESPONSE REGULATOR receiver
VS_RS05095	COG1434	Gram-negative-bacterium-type cell wall biogenesis
VS_RS05100	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VS_RS05110	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
VS_RS05115	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
VS_RS05135	COG4067	protein conserved in archaea
VS_RS05135	COG0189	ligase activity
VS_RS05150	COG1801	Protein of unknown function DUF72
VS_RS05165	COG0840	transmembrane signaling receptor activity
VS_RS05180	COG1271	oxidase subunit
VS_RS05185	COG1294	oxidase, subunit
VS_RS05200	COG0824	Thioesterase
VS_RS05205	COG0811	peptide transport
VS_RS05225	COG2885	chlorophyll binding
VS_RS05230	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
VS_RS05235	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
VS_RS05240	COG1629	transport
VS_RS05240	COG4774	siderophore transport
VS_RS05245	COG2375	cellular response to nickel ion
VS_RS05250	COG4592	Periplasmic binding protein
VS_RS05255	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VS_RS05260	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VS_RS05265	COG1120	ATPase activity
VS_RS05280	COG5002	protein histidine kinase activity
VS_RS05280	COG0784	Response regulator, receiver
VS_RS05295	COG0583	DNA-binding transcription factor activity
VS_RS05320	COG0745	RESPONSE REGULATOR receiver
VS_RS05325	COG0463	Glycosyl transferase, family 2
VS_RS05330	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
VS_RS05340	COG1032	radical SAM domain protein
VS_RS05355	COG0583	DNA-binding transcription factor activity
VS_RS05360	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
VS_RS05370	COG2350	Protein conserved in bacteria
VS_RS05375	COG1607	acyl-coa hydrolase
VS_RS05420	COG3706	GGDEF domain
VS_RS05420	COG4251	negative regulation of phosphorylation
VS_RS05420	COG5001	Diguanylate cyclase
VS_RS05420	COG2203	Gaf domain
VS_RS05425	COG0840	transmembrane signaling receptor activity
VS_RS05445	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
VS_RS05450	COG4136	ATPase activity
VS_RS05455	COG4135	transport system, permease component
VS_RS05460	COG4134	Bacterial extracellular solute-binding protein
VS_RS05470	COG3313	Fe-S protein
VS_RS05485	COG0513	Belongs to the DEAD box helicase family
VS_RS05490	COG1280	lysine exporter protein (LysE YggA)
VS_RS05500	COG2866	Carboxypeptidase
VS_RS05525	COG4176	ABC-type proline glycine betaine transport system permease component
VS_RS05530	COG2113	Glycine betaine
VS_RS05540	COG0583	DNA-binding transcription factor activity
VS_RS05545	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
VS_RS05550	COG4988	ABC transporter
VS_RS05555	COG0492	ferredoxin-NADP+ reductase activity
VS_RS05585	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VS_RS05600	COG3706	GGDEF domain
VS_RS05620	COG0471	metal ion transport
VS_RS05625	COG2949	membrane
VS_RS05630	COG0281	malic enzyme
VS_RS05635	COG1643	Atp-dependent helicase
VS_RS05680	COG0277	FAD linked oxidase domain protein
VS_RS05680	COG0247	lactate metabolic process
VS_RS05700	COG2986	histidine ammonia-lyase
VS_RS05710	COG0010	Belongs to the arginase family
VS_RS05715	COG1228	amidohydrolase
VS_RS05725	COG4326	sporulation control protein
VS_RS05760	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
VS_RS05795	COG0488	(ABC) transporter
VS_RS05800	COG1309	transcriptional regulator
VS_RS05810	COG1166	arginine decarboxylase activity
VS_RS05815	COG0010	Belongs to the arginase family
VS_RS05825	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VS_RS05830	COG0800	Aldolase
VS_RS05835	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VS_RS05840	COG1917	Cupin 2, conserved barrel domain protein
VS_RS05865	COG2186	Transcriptional regulator
VS_RS05870	COG2186	Transcriptional regulator
VS_RS05875	COG0517	IMP dehydrogenase activity
VS_RS05880	COG2176	DNA-directed DNA polymerase activity
VS_RS05895	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VS_RS05975	COG0471	metal ion transport
VS_RS05980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VS_RS05980	COG4191	Histidine kinase
VS_RS06030	COG0730	response to heat
VS_RS06055	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
VS_RS06060	COG1280	lysine exporter protein (LysE YggA)
VS_RS06065	COG1115	amino acid carrier protein
VS_RS06085	COG1115	amino acid carrier protein
VS_RS06100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VS_RS06115	COG3290	protein histidine kinase activity
VS_RS06120	COG4565	transcriptional regulatory protein
VS_RS06125	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
VS_RS06130	COG0363	glucosamine-6-phosphate deaminase activity
VS_RS06135	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
VS_RS06145	COG4628	conserved protein (DUF2132)
VS_RS06180	COG3437	response regulator, receiver
VS_RS06295	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
VS_RS06305	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
VS_RS06310	COG0372	Belongs to the citrate synthase family
VS_RS06315	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
VS_RS06320	COG2828	Protein conserved in bacteria
VS_RS06350	COG0561	phosphatase activity
VS_RS06355	COG0602	queuosine metabolic process
VS_RS06365	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
VS_RS06390	COG0484	heat shock protein binding
VS_RS06450	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
VS_RS06490	COG1196	nuclear chromosome segregation
VS_RS06520	COG3706	GGDEF domain
VS_RS06530	COG2885	chlorophyll binding
VS_RS06530	COG3047	cAMP biosynthetic process
VS_RS06555	COG1254	Belongs to the acylphosphatase family
VS_RS06560	COG2920	part of a sulfur-relay system
VS_RS06565	COG0670	Belongs to the BI1 family
VS_RS06570	COG1126	abc transporter atp-binding protein
VS_RS06575	COG0765	amino acid transport
VS_RS06580	COG4597	amino acid ABC transporter
VS_RS06585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VS_RS06600	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VS_RS06605	COG0574	Belongs to the PEP-utilizing enzyme family
VS_RS06605	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
VS_RS06620	COG2996	Protein conserved in bacteria
VS_RS06630	COG3008	intermembrane lipid transfer
VS_RS06635	COG2995	paraquat-inducible protein a
VS_RS06640	COG1132	(ABC) transporter
VS_RS06645	COG1956	GAF domain-containing protein
VS_RS06665	COG0308	aminopeptidase N
VS_RS06670	COG2902	Dehydrogenase
VS_RS06685	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VS_RS06685	COG0116	Belongs to the methyltransferase superfamily
VS_RS06715	COG1067	ATP-dependent peptidase activity
VS_RS06815	COG2801	Transposase and inactivated derivatives
VS_RS06820	COG0784	Response regulator, receiver
VS_RS06820	COG5002	protein histidine kinase activity
VS_RS06835	COG3278	Belongs to the heme-copper respiratory oxidase family
VS_RS06850	COG2010	Cytochrome c
VS_RS06860	COG2217	Heavy metal translocating P-type atpase
VS_RS06875	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VS_RS06880	COG0589	response to stress
VS_RS06885	COG0037	tRNA processing
VS_RS06905	COG3842	ATPase activity
VS_RS06915	COG1177	transmembrane transport
VS_RS06925	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VS_RS06935	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
VS_RS06940	COG0004	ammonium transporteR
VS_RS06955	COG0437	4 iron, 4 sulfur cluster binding
VS_RS06960	COG3383	formate dehydrogenase (NAD+) activity
VS_RS06960	COG0243	molybdopterin cofactor binding
VS_RS06970	COG3381	protein complex oligomerization
VS_RS06990	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
VS_RS07010	COG4191	Histidine kinase
VS_RS07015	COG2204	response regulator
VS_RS07025	COG4662	Binding-protein-dependent transport system inner membrane component
VS_RS07030	COG3842	ATPase activity
VS_RS07040	COG0303	'Molybdopterin
VS_RS07045	COG3706	GGDEF domain
VS_RS07075	COG0791	NLP P60 protein
VS_RS07090	COG0307	riboflavin synthase, alpha
VS_RS07095	COG0534	Mate efflux family protein
VS_RS07100	COG1793	dna ligase
VS_RS07110	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
VS_RS07110	COG2885	chlorophyll binding
VS_RS07130	COG4176	ABC-type proline glycine betaine transport system permease component
VS_RS07135	COG3448	diguanylate cyclase activity
VS_RS07135	COG4175	Glycine betaine
VS_RS07145	COG2204	response regulator
VS_RS07150	COG0438	transferase activity, transferring glycosyl groups
VS_RS07175	COG0438	transferase activity, transferring glycosyl groups
VS_RS07180	COG1215	transferase activity, transferring glycosyl groups
VS_RS07185	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VS_RS07250	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VS_RS07255	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VS_RS07285	COG4160	amino acid transport
VS_RS07290	COG4215	(ABC) transporter
VS_RS07295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VS_RS07300	COG1126	abc transporter atp-binding protein
VS_RS07315	COG0826	peptidase U32
VS_RS07330	COG0786	glutamate:sodium symporter activity
VS_RS07360	COG1028	Short-chain dehydrogenase reductase Sdr
VS_RS07370	COG0546	phosphoglycolate phosphatase activity
VS_RS07375	COG0653	protein targeting
VS_RS07395	COG0346	lactoylglutathione lyase activity
VS_RS07400	COG1280	lysine exporter protein (LysE YggA)
VS_RS07425	COG1051	belongs to the nudix hydrolase family
VS_RS07440	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VS_RS07470	COG1187	pseudouridine synthase activity
VS_RS07485	COG0494	nUDIX hydrolase
VS_RS07510	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VS_RS07520	COG0584	glycerophosphoryl diester phosphodiesterase
VS_RS07525	COG2271	Major facilitator Superfamily
VS_RS07555	COG0589	response to stress
VS_RS07560	COG0415	Belongs to the DNA photolyase family
VS_RS07565	COG3046	protein related to deoxyribodipyrimidine photolyase
VS_RS07580	COG0419	ATPase involved in DNA repair
VS_RS07585	COG0420	3'-5' exonuclease activity
VS_RS07605	COG0454	-acetyltransferase
VS_RS07610	COG2199	diguanylate cyclase activity
VS_RS07620	COG4771	TonB-dependent receptor
VS_RS07635	COG0840	transmembrane signaling receptor activity
VS_RS07650	COG3119	arylsulfatase activity
VS_RS07660	COG0583	DNA-binding transcription factor activity
VS_RS07695	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
VS_RS07705	COG0210	DNA helicase
VS_RS07720	COG0328	RNA-DNA hybrid ribonuclease activity
VS_RS07730	COG2003	Belongs to the UPF0758 family
VS_RS07790	COG0582	viral genome integration into host DNA
VS_RS07810	COG3706	GGDEF domain
VS_RS07815	COG2195	Cleaves the N-terminal amino acid of tripeptides
VS_RS07835	COG3063	Type IV pilus biogenesis stability protein PilW
VS_RS07845	COG1451	nucleotide metabolic process
VS_RS07855	COG0583	DNA-binding transcription factor activity
VS_RS07860	COG2814	Major facilitator Superfamily
VS_RS07870	COG2203	Gaf domain
VS_RS07870	COG2199	diguanylate cyclase activity
VS_RS07880	COG1247	-acetyltransferase
VS_RS07890	COG1294	oxidase, subunit
VS_RS07895	COG1271	oxidase subunit
VS_RS07900	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VS_RS07920	COG4139	cobalamin transport
VS_RS07925	COG2988	succinylglutamate desuccinylase activity
VS_RS07945	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
VS_RS07955	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
VS_RS07960	COG0702	epimerase
VS_RS07975	COG3122	Protein conserved in bacteria
VS_RS07980	COG3568	Endonuclease Exonuclease Phosphatase
VS_RS08005	COG2925	Exonuclease
VS_RS08015	COG1346	cytolysis
VS_RS08025	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
VS_RS08050	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VS_RS08065	COG2175	clavaminate synthase activity
VS_RS08075	COG0840	transmembrane signaling receptor activity
VS_RS08105	COG0776	regulation of translation
VS_RS08120	COG1342	Belongs to the UPF0251 family
VS_RS08135	COG2873	o-acetylhomoserine
VS_RS08140	COG1522	sequence-specific DNA binding
VS_RS08155	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VS_RS08160	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
VS_RS08245	COG0072	phenylalanine-tRNA ligase activity
VS_RS08245	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VS_RS08290	COG1643	Atp-dependent helicase
VS_RS08320	COG3710	Transcriptional regulator
VS_RS08340	COG3706	GGDEF domain
VS_RS08370	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VS_RS08385	COG3106	COG3106 Predicted ATPase
VS_RS08410	COG5002	protein histidine kinase activity
VS_RS08410	COG0784	Response regulator, receiver
VS_RS08420	COG0494	nUDIX hydrolase
VS_RS08425	COG0814	amino acid
VS_RS08430	COG1760	l-serine dehydratase
VS_RS08435	COG0814	amino acid
VS_RS08440	COG0720	synthase
VS_RS08445	COG0840	transmembrane signaling receptor activity
VS_RS08450	COG0659	secondary active sulfate transmembrane transporter activity
VS_RS08455	COG0017	Asparaginyl-tRNA synthetase
VS_RS08480	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VS_RS08490	COG2770	Histidine kinase
VS_RS08490	COG3437	response regulator, receiver
VS_RS08505	COG1448	Aminotransferase
VS_RS08520	COG2176	DNA-directed DNA polymerase activity
VS_RS08525	COG2258	MOSC domain
VS_RS08530	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
VS_RS08540	COG4191	Histidine kinase
VS_RS08545	COG2204	response regulator
VS_RS08555	COG3070	regulator of competence-specific genes
VS_RS08570	COG2431	L-lysine efflux transmembrane transporter activity
VS_RS08580	COG0076	glutamate decarboxylase activity
VS_RS08585	COG1737	Transcriptional regulator
VS_RS08595	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VS_RS08635	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VS_RS08660	COG0702	epimerase
VS_RS08670	COG2814	Major facilitator Superfamily
VS_RS08680	COG1061	Type III restriction enzyme res subunit
VS_RS08685	COG5001	Diguanylate cyclase
VS_RS08685	COG5002	protein histidine kinase activity
VS_RS08700	COG0642	Histidine kinase
VS_RS08705	COG0586	Pfam SNARE associated Golgi protein
VS_RS08755	COG3547	Transposase (IS116 IS110 IS902 family)
VS_RS08785	COG0494	nUDIX hydrolase
VS_RS08800	COG3547	Transposase (IS116 IS110 IS902 family)
VS_RS08830	COG2732	(Barnase) inhibitor
VS_RS08855	COG2124	cytochrome p450
VS_RS08890	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VS_RS08895	COG1780	Probably involved in ribonucleotide reductase function
VS_RS08905	COG0316	Belongs to the HesB IscA family
VS_RS08910	COG0719	Fe-S assembly protein
VS_RS08915	COG0396	ATPase activity
VS_RS08920	COG0719	Fe-S assembly protein
VS_RS08925	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VS_RS08930	COG2166	iron-sulfur cluster assembly
VS_RS08935	COG0840	transmembrane signaling receptor activity
VS_RS08940	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VS_RS08945	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VS_RS08970	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
VS_RS08985	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VS_RS08990	COG3108	Peptidase M15
VS_RS08995	COG2989	Protein conserved in bacteria
VS_RS09020	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VS_RS09030	COG3088	subunit of a heme lyase
VS_RS09030	COG4235	cytochrome complex assembly
VS_RS09040	COG1138	Cytochrome C-type biogenesis protein
VS_RS09045	COG3301	Polysulphide reductase, NrfD
VS_RS09050	COG0437	4 iron, 4 sulfur cluster binding
VS_RS09055	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
VS_RS09060	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
VS_RS09065	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VS_RS09085	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VS_RS09090	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VS_RS09115	COG0019	diaminopimelate decarboxylase activity
VS_RS09160	COG2197	response regulator
VS_RS09165	COG0417	DNA replication proofreading
VS_RS09190	COG1187	pseudouridine synthase activity
VS_RS09195	COG0009	L-threonylcarbamoyladenylate synthase
VS_RS09200	COG0613	PHP domain protein
VS_RS09210	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VS_RS09215	COG0512	Glutamine amidotransferase of anthranilate synthase
VS_RS09220	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
VS_RS09225	COG0135	phosphoribosylanthranilate isomerase activity
VS_RS09225	COG0134	indole-3-glycerol-phosphate synthase activity
VS_RS09240	COG0330	HflC and HflK could
VS_RS09250	COG1301	dicarboxylic acid transport
VS_RS09270	COG0564	pseudouridine synthase activity
VS_RS09280	COG0733	neurotransmitter:sodium symporter activity
VS_RS09290	COG0626	cystathionine gamma-synthase activity
VS_RS09305	COG2818	Glycosylase
VS_RS09320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VS_RS09325	COG1983	PspC domain protein
VS_RS09335	COG1842	Phage shock protein A
VS_RS09340	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
VS_RS09345	COG4166	transmembrane transport
VS_RS09350	COG4168	peptide transport system, permease
VS_RS09365	COG4172	Belongs to the ABC transporter superfamily
VS_RS09380	COG1227	inorganic diphosphatase activity
VS_RS09390	COG0243	molybdopterin cofactor binding
VS_RS09395	COG3005	denitrification pathway
VS_RS09400	COG4459	periplasmic nitrate reductase
VS_RS09405	COG0390	transport system, permease component
VS_RS09410	COG2116	formate transmembrane transporter activity
VS_RS09445	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VS_RS09455	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VS_RS09460	COG3012	SEC-C Motif Domain Protein
VS_RS09465	COG0140	phosphoribosyl-ATP diphosphatase activity
VS_RS09465	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
VS_RS09475	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
VS_RS09480	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
VS_RS09485	COG0131	Imidazoleglycerol-phosphate dehydratase
VS_RS09485	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VS_RS09490	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VS_RS09505	COG1757	Na H antiporter
VS_RS09510	COG2916	Histone family protein nucleoid-structuring protein H-NS
VS_RS09515	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VS_RS09535	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
VS_RS09565	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
VS_RS09580	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
VS_RS09590	COG1674	ftsk spoiiie
VS_RS09595	COG1522	sequence-specific DNA binding
VS_RS09600	COG0686	Belongs to the AlaDH PNT family
VS_RS09610	COG0583	DNA-binding transcription factor activity
VS_RS09630	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
VS_RS09635	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
VS_RS09645	COG0539	negative regulation of cytoplasmic translation
VS_RS09655	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
VS_RS09670	COG1132	(ABC) transporter
VS_RS09675	COG2333	competence protein COMEC
VS_RS09675	COG0658	competence protein
VS_RS09685	COG4591	ABC-type transport system involved in lipoprotein release permease component
VS_RS09690	COG1136	(ABC) transporter
VS_RS09695	COG4591	ABC-type transport system involved in lipoprotein release permease component
VS_RS09705	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
VS_RS09720	COG1252	NADH dehydrogenase
VS_RS09750	COG0537	adenosine 5'-monophosphoramidase activity
VS_RS09780	COG0617	tRNA 3'-terminal CCA addition
VS_RS09780	COG0517	IMP dehydrogenase activity
VS_RS09780	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
VS_RS09805	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VS_RS09810	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VS_RS09825	COG1902	pentaerythritol trinitrate reductase activity
VS_RS09830	COG0346	lactoylglutathione lyase activity
VS_RS09855	COG2015	COG2015, Alkyl sulfatase and related hydrolases
VS_RS09865	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VS_RS09875	COG1309	transcriptional regulator
VS_RS09880	COG0583	DNA-binding transcription factor activity
VS_RS09895	COG3040	lipid binding
VS_RS09900	COG1574	metal-dependent hydrolase with the TIM-barrel fold
VS_RS09910	COG1120	ATPase activity
VS_RS09915	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VS_RS09945	COG3118	belongs to the thioredoxin family
VS_RS09950	COG4232	protein-disulfide reductase activity
VS_RS09970	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
VS_RS09990	COG1280	lysine exporter protein (LysE YggA)
VS_RS09995	COG1522	sequence-specific DNA binding
VS_RS10010	COG0789	Transcriptional regulator
VS_RS10015	COG0583	DNA-binding transcription factor activity
VS_RS10055	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
VS_RS10085	COG0463	Glycosyl transferase, family 2
VS_RS10085	COG1216	Glycosyl transferase, family 2
VS_RS10090	COG0438	transferase activity, transferring glycosyl groups
VS_RS10095	COG0328	RNA-DNA hybrid ribonuclease activity
VS_RS10095	COG3341	Caulimovirus viroplasmin
VS_RS10125	COG4106	trans-aconitate 2-methyltransferase activity
VS_RS10140	COG3126	Type III secretion system lipoprotein chaperone (YscW)
VS_RS10145	COG1946	Acyl-CoA thioesterase
VS_RS10155	COG1522	sequence-specific DNA binding
VS_RS10170	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VS_RS10230	COG2855	membrane
VS_RS10245	COG2190	(PTS) system
VS_RS10245	COG1263	PTS System
VS_RS10245	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VS_RS10260	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
VS_RS10265	COG2267	carboxylic ester hydrolase activity
VS_RS10275	COG1169	isochorismate synthase
VS_RS10280	COG0436	Aminotransferase
VS_RS10290	COG0232	Belongs to the dGTPase family. Type 2 subfamily
VS_RS10305	COG1555	photosystem II stabilization
VS_RS10310	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VS_RS10315	COG0776	regulation of translation
VS_RS10320	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
VS_RS10345	COG2204	response regulator
VS_RS10350	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VS_RS10355	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VS_RS10360	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VS_RS10380	COG3321	synthase
VS_RS10380	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
VS_RS10395	COG2070	2-Nitropropane dioxygenase
VS_RS10395	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
VS_RS10400	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
VS_RS10405	COG0318	PFAM AMP-dependent synthetase and ligase
VS_RS10410	COG2267	carboxylic ester hydrolase activity
VS_RS10425	COG1214	PFAM Peptidase M22, glycoprotease
VS_RS10430	COG1199	ATP-dependent helicase activity
VS_RS10440	COG0788	formyltetrahydrofolate deformylase activity
VS_RS10445	COG3102	Protein conserved in bacteria
VS_RS10485	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
VS_RS10490	COG1121	(ABC) transporter
VS_RS10495	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VS_RS10510	COG0508	dehydrogenase complex catalyzes the overall conversion of
VS_RS10515	COG0567	Dehydrogenase, E1 component
VS_RS10530	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
VS_RS10540	COG0372	Belongs to the citrate synthase family
VS_RS10545	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
VS_RS10555	COG0033	Phosphoglucomutase
VS_RS10565	COG0596	Alpha beta hydrolase
VS_RS10595	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VS_RS10595	COG2190	(PTS) system
VS_RS10595	COG1263	PTS System
VS_RS10600	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
VS_RS10605	COG1940	carbohydrate kinase activity
VS_RS10605	COG1846	Transcriptional regulator
VS_RS10610	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VS_RS10610	COG4651	solute:proton antiporter activity
VS_RS10615	COG0367	asparagine synthase
VS_RS10620	COG0250	Participates in transcription elongation, termination and antitermination
VS_RS10625	COG3104	oligopeptide transport
VS_RS10645	COG3710	Transcriptional regulator
VS_RS10660	COG0622	Phosphoesterase
VS_RS10685	COG1090	epimerase
VS_RS10690	COG0300	oxidoreductase activity
VS_RS10695	COG3118	belongs to the thioredoxin family
VS_RS10700	COG0330	HflC and HflK could
VS_RS10710	COG0789	Transcriptional regulator
VS_RS10745	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VS_RS10755	COG2190	(PTS) system
VS_RS10760	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VS_RS10765	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VS_RS10770	COG2837	iron assimilation
VS_RS10795	COG1393	Belongs to the ArsC family
VS_RS10820	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VS_RS10830	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
VS_RS10845	COG4783	chaperone-mediated protein folding
VS_RS10850	COG1393	Belongs to the ArsC family
VS_RS10870	COG2233	PERMEase
VS_RS10875	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
VS_RS10885	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
VS_RS10890	COG0121	glutamine amidotransferase
VS_RS10895	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VS_RS10900	COG1960	acyl-CoA dehydrogenase activity
VS_RS10910	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
VS_RS10930	COG2226	methyltransferase
VS_RS10940	COG1388	LysM domain
VS_RS10940	COG0741	lytic transglycosylase activity
VS_RS10950	COG3021	interspecies interaction between organisms
VS_RS10955	COG0347	Belongs to the P(II) protein family
VS_RS10975	COG0587	DNA-directed DNA polymerase activity
VS_RS11000	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VS_RS11005	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
VS_RS11015	COG0750	zinc metalloprotease
VS_RS11025	COG0575	Belongs to the CDS family
VS_RS11030	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
VS_RS11040	COG0233	cytoplasmic translational termination
VS_RS11045	COG0528	UMP kinase activity
VS_RS11055	COG0052	Belongs to the universal ribosomal protein uS2 family
VS_RS11060	COG0024	Methionine aminopeptidase
VS_RS11075	COG0564	pseudouridine synthase activity
VS_RS11080	COG3098	single-species biofilm formation
VS_RS11110	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
VS_RS11120	COG1720	tRNA m6t6A37 methyltransferase activity
VS_RS11150	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VS_RS11155	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
VS_RS11170	COG0366	Alpha amylase catalytic
VS_RS11175	COG1263	PTS System
VS_RS11175	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VS_RS11180	COG1609	Transcriptional regulator
VS_RS11190	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VS_RS11195	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
VS_RS11200	COG2011	ABC-type metal ion transport system permease component
VS_RS11205	COG1464	Belongs to the NlpA lipoprotein family
VS_RS11225	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
VS_RS11250	COG1611	Belongs to the LOG family
VS_RS11280	COG0583	DNA-binding transcription factor activity
VS_RS11295	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
VS_RS11305	COG0142	geranyltranstransferase activity
VS_RS11315	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
VS_RS11320	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
VS_RS11345	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VS_RS11345	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VS_RS11380	COG2252	PERMEase
VS_RS11390	COG2195	Cleaves the N-terminal amino acid of tripeptides
VS_RS11420	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
VS_RS11425	COG0583	DNA-binding transcription factor activity
VS_RS11430	COG2059	Chromate
VS_RS11435	COG2226	methyltransferase
VS_RS11495	COG4964	Belongs to the GSP D family
VS_RS11525	COG1022	Amp-dependent synthetase and ligase
VS_RS11535	COG0583	DNA-binding transcription factor activity
VS_RS11540	COG4628	conserved protein (DUF2132)
VS_RS11545	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VS_RS11550	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
VS_RS11560	COG0560	Phosphoserine phosphatase
VS_RS11570	COG0813	purine-nucleoside phosphorylase activity
VS_RS11575	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
VS_RS11580	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
VS_RS11590	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VS_RS11595	COG0084	hydrolase, TatD family'
VS_RS11615	COG3153	acetyltransferase
VS_RS11620	COG3154	lipid carrier protein
VS_RS11630	COG0826	peptidase U32
VS_RS11635	COG0826	peptidase U32
VS_RS11640	COG0534	Mate efflux family protein
VS_RS11680	COG0195	Participates in both transcription termination and antitermination
VS_RS11700	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VS_RS11710	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
VS_RS11715	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VS_RS11725	COG1534	Rna-binding protein
VS_RS11730	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VS_RS11740	COG2027	D-alanyl-D-alanine carboxypeptidase
VS_RS11745	COG2239	Acts as a magnesium transporter
VS_RS11750	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VS_RS11755	COG0739	heme binding
VS_RS11785	COG0628	permease
VS_RS11790	COG2813	Specifically methylates the guanine in position
VS_RS11800	COG0747	negative chemotaxis
VS_RS11810	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VS_RS11815	COG0444	Belongs to the ABC transporter superfamily
VS_RS11820	COG4608	Belongs to the ABC transporter superfamily
VS_RS11830	COG2971	BadF BadG BcrA BcrD
VS_RS11845	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VS_RS11850	COG3842	ATPase activity
VS_RS11860	COG1840	ABC-type Fe3 transport system, periplasmic component
VS_RS11865	COG0004	ammonium transporteR
VS_RS11880	COG1049	propionate catabolic process, 2-methylcitrate cycle
VS_RS11885	COG1752	Esterase of the alpha-beta hydrolase superfamily
VS_RS11890	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VS_RS11895	COG1643	Atp-dependent helicase
VS_RS11920	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VS_RS11935	COG0842	Transport permease protein
VS_RS11940	COG1131	(ABC) transporter
VS_RS11945	COG0659	secondary active sulfate transmembrane transporter activity
VS_RS11950	COG0288	reversible hydration of carbon dioxide
VS_RS11965	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VS_RS11970	COG0508	dehydrogenase complex catalyzes the overall conversion of
VS_RS11975	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
VS_RS11980	COG2186	Transcriptional regulator
VS_RS12000	COG0157	Belongs to the NadC ModD family
VS_RS12010	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VS_RS12015	COG1459	type II secretion system
VS_RS12060	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
VS_RS12065	COG4137	Cytochrome C assembly protein
VS_RS12070	COG4536	flavin adenine dinucleotide binding
VS_RS12090	COG0612	Peptidase, M16
VS_RS12095	COG1238	metal cluster binding
VS_RS12100	COG1064	alcohol dehydrogenase
VS_RS12105	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
VS_RS12110	COG0511	ligase activity, forming carbon-carbon bonds
VS_RS12110	COG5016	pyruvate
VS_RS12115	COG3630	sodium ion export across plasma membrane
VS_RS12175	COG0527	aspartate kinase activity
VS_RS12190	COG3842	ATPase activity
VS_RS12200	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VS_RS12210	COG2182	Extracellular solute-binding protein
VS_RS12215	COG1175	transmembrane transport
VS_RS12220	COG3833	ABC-type maltose transport systems, permease component
VS_RS12240	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
VS_RS12245	COG1546	Belongs to the CinA family
VS_RS12255	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VS_RS12270	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
VS_RS12275	COG0585	pseudouridine synthase activity
VS_RS12295	COG0148	phosphopyruvate hydratase activity
VS_RS12305	COG3956	TIGRFAM MazG family protein
VS_RS12310	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VS_RS12320	COG3850	Histidine kinase
VS_RS12320	COG3437	response regulator, receiver
VS_RS12320	COG2205	protein histidine kinase activity
VS_RS12320	COG4999	Histidine kinase
VS_RS12330	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
VS_RS12340	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
VS_RS12375	COG1595	DNA-templated transcription, initiation
VS_RS12380	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
VS_RS12385	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
VS_RS12405	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VS_RS12410	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VS_RS12420	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
VS_RS12425	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
VS_RS12435	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VS_RS12450	COG1279	arginine transmembrane transporter activity
VS_RS12455	COG0668	transmembrane transport
VS_RS12460	COG0191	fructose-bisphosphate aldolase activity
VS_RS12480	COG1653	transport
VS_RS12485	COG0642	Histidine kinase
VS_RS12490	COG0745	RESPONSE REGULATOR receiver
VS_RS12500	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VS_RS12520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VS_RS12525	COG0588	phosphoglycerate mutase activity
VS_RS12530	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
VS_RS12570	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
VS_RS12595	COG2356	endonuclease I
VS_RS12605	COG1385	rRNA (uridine-N3-)-methyltransferase activity
VS_RS12610	COG0189	ligase activity
VS_RS12620	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
VS_RS12635	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
VS_RS12640	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
VS_RS12645	COG0762	integral membrane protein
VS_RS12660	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
VS_RS12665	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VS_RS12690	COG0741	lytic transglycosylase activity
VS_RS12795	COG3437	response regulator, receiver
VS_RS12815	COG0795	lipopolysaccharide-transporting ATPase activity
VS_RS12820	COG0795	lipopolysaccharide-transporting ATPase activity
VS_RS12830	COG2927	DNA polymerase III (CHI subunit)
VS_RS12835	COG0525	valine-tRNA ligase activity
VS_RS12880	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
VS_RS12885	COG0251	oxidation-reduction process
VS_RS12890	COG0204	Acyl-transferase
VS_RS12900	COG5007	Belongs to the BolA IbaG family
VS_RS12910	COG2854	intermembrane phospholipid transfer
VS_RS12915	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VS_RS12920	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
VS_RS12925	COG1127	ABC transporter
VS_RS12935	COG0517	IMP dehydrogenase activity
VS_RS12935	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
VS_RS12940	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
VS_RS12950	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
VS_RS12955	COG1137	ATPase activity
VS_RS12965	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VS_RS12970	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VS_RS12980	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VS_RS12985	COG2239	Acts as a magnesium transporter
VS_RS12990	COG0312	modulator of DNA gyrase
VS_RS13000	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
VS_RS13005	COG1178	ABC-type Fe3 transport system permease component
VS_RS13015	COG0163	prenyltransferase activity
VS_RS13020	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VS_RS13035	COG2105	PFAM AIG2 family protein
VS_RS13040	COG2911	Protein conserved in bacteria
VS_RS13045	COG0729	surface antigen
VS_RS13050	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VS_RS13055	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
VS_RS13085	COG0529	Catalyzes the synthesis of activated sulfate
VS_RS13090	COG0471	metal ion transport
VS_RS13090	COG3273	potassium ion transport
VS_RS13150	COG2153	protein acetylation
VS_RS13160	COG3266	domain, Protein
VS_RS13160	COG3061	Opacity-associated protein A
VS_RS13165	COG0545	Peptidyl-prolyl cis-trans isomerase
VS_RS13195	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
VS_RS13200	COG0257	Belongs to the bacterial ribosomal protein bL36 family
VS_RS13205	COG0201	protein transport
VS_RS13215	COG1841	ribosomal large subunit assembly
VS_RS13240	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
VS_RS13320	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VS_RS13340	COG2923	Belongs to the DsrF TusC family
VS_RS13345	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
VS_RS13350	COG2964	Protein conserved in bacteria
VS_RS13355	COG0545	Peptidyl-prolyl cis-trans isomerase
VS_RS13370	COG1446	asparaginase
VS_RS13375	COG1047	Peptidyl-prolyl cis-trans
VS_RS13395	COG0488	(ABC) transporter
VS_RS13405	COG0429	hydrolase of the alpha beta-hydrolase fold
VS_RS13415	COG3954	Phosphoribulokinase
VS_RS13420	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VS_RS13450	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
VS_RS13455	COG0512	Glutamine amidotransferase of anthranilate synthase
VS_RS13470	COG0180	Tryptophanyl-tRNA synthetase
VS_RS13475	COG0546	phosphoglycolate phosphatase activity
VS_RS13480	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
VS_RS13485	COG0338	D12 class N6 adenine-specific DNA methyltransferase
VS_RS13530	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
VS_RS13540	COG0678	peroxiredoxin activity
VS_RS13540	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VS_RS13545	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VS_RS13550	COG0251	oxidation-reduction process
VS_RS13560	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VS_RS13560	COG0165	Argininosuccinate lyase
VS_RS13575	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
VS_RS13595	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
VS_RS13600	COG0527	aspartate kinase activity
VS_RS13600	COG0460	homoserine dehydrogenase
VS_RS13605	COG0626	cystathionine gamma-synthase activity
VS_RS13615	COG0281	malic enzyme
VS_RS13625	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
VS_RS13630	COG1609	Transcriptional regulator
VS_RS13650	COG1575	Belongs to the MenA family. Type 1 subfamily
VS_RS13655	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VS_RS13665	COG1494	fructose-1,6-bisphosphatase
VS_RS13680	COG3152	Membrane
VS_RS13700	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
VS_RS13710	COG0745	RESPONSE REGULATOR receiver
VS_RS13715	COG2205	protein histidine kinase activity
VS_RS13725	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
VS_RS13735	COG1027	Aspartate ammonia-lyase
VS_RS13740	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VS_RS13745	COG1288	antiporter activity
VS_RS13765	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
VS_RS13770	COG0540	Belongs to the ATCase OTCase family
VS_RS13775	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
VS_RS13780	COG1438	arginine binding
VS_RS13785	COG4232	protein-disulfide reductase activity
VS_RS13795	COG3263	regulation of cellular component size
VS_RS13805	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VS_RS13820	COG2198	Histidine kinase
VS_RS13820	COG0784	Response regulator, receiver
VS_RS13820	COG2205	protein histidine kinase activity
VS_RS13825	COG2814	Major facilitator Superfamily
VS_RS13840	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VS_RS13845	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
VS_RS13850	COG0511	ligase activity, forming carbon-carbon bonds
VS_RS13855	COG0439	Biotin carboxylase
VS_RS13865	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VS_RS13875	COG3706	GGDEF domain
VS_RS13880	COG0789	Transcriptional regulator
VS_RS13890	COG0151	Belongs to the GarS family
VS_RS13905	COG1253	flavin adenine dinucleotide binding
VS_RS13910	COG3068	Protein conserved in bacteria
VS_RS13920	COG1573	uracil-dna glycosylase
VS_RS13935	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
VS_RS13955	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
VS_RS13970	COG0250	Participates in transcription elongation, termination and antitermination
VS_RS14005	COG1072	(Pantothenic acid kinase))
VS_RS14015	COG0812	UDP-N-acetylmuramate dehydrogenase activity
VS_RS14025	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VS_RS14030	COG3335	DDE superfamily endonuclease
VS_RS14070	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
VS_RS14080	COG4206	TonB-dependent receptor
VS_RS14105	COG0534	Mate efflux family protein
VS_RS14110	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
VS_RS14120	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
VS_RS14145	COG3161	chorismate lyase activity
VS_RS14150	COG1580	Controls the rotational direction of flagella during chemotaxis
VS_RS14155	COG0705	Rhomboid family
VS_RS14170	COG2177	Part of the ABC transporter FtsEX involved in
VS_RS14175	COG2884	Cell division ATP-binding protein ftsE
VS_RS14180	COG0552	protein localization to endoplasmic reticulum
VS_RS14180	COG0552	protein localization to endoplasmic reticulum
VS_RS14185	COG0742	ribosomal rna small subunit methyltransferase
VS_RS14195	COG2095	MarC family integral membrane protein
VS_RS14235	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VS_RS14240	COG0640	Transcriptional regulator
VS_RS14245	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VS_RS14250	COG1280	lysine exporter protein (LysE YggA)
VS_RS14255	COG2267	carboxylic ester hydrolase activity
VS_RS14260	COG0561	phosphatase activity
VS_RS14280	COG3287	FIST C domain
VS_RS14280	COG2199	diguanylate cyclase activity
VS_RS14280	COG2200	EAL domain
VS_RS14285	COG3287	FIST C domain
VS_RS14285	COG2200	EAL domain
VS_RS14285	COG2199	diguanylate cyclase activity
VS_RS14290	COG1011	Hydrolase
VS_RS14310	COG0019	diaminopimelate decarboxylase activity
VS_RS14325	COG3072	Adenylate cyclase
VS_RS14335	COG1587	Uroporphyrinogen-III synthase
VS_RS14340	COG2959	enzyme of heme biosynthesis
VS_RS14345	COG3071	HemY protein
VS_RS14380	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
VS_RS14395	COG3118	belongs to the thioredoxin family
VS_RS14410	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
VS_RS14420	COG0514	ATP-dependent DNA helicase (RecQ)
VS_RS14425	COG2962	Rard protein
VS_RS14435	COG1280	lysine exporter protein (LysE YggA)
VS_RS14440	COG0405	Gamma-glutamyltransferase
VS_RS14450	COG0210	DNA helicase
VS_RS14460	COG3220	belongs to the UPF0276 family
VS_RS14490	COG0006	proline dipeptidase activity
VS_RS14490	COG0006	proline dipeptidase activity
VS_RS14505	COG2104	thiamine diphosphate biosynthetic process
VS_RS14510	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VS_RS14515	COG0352	thiamine-phosphate diphosphorylase activity
VS_RS14530	COG2132	Multicopper oxidase
VS_RS14575	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
VS_RS14595	COG0009	L-threonylcarbamoyladenylate synthase
VS_RS14600	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
VS_RS14605	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
VS_RS14610	COG0551	DNA topoisomerase type I activity
VS_RS14620	COG0758	DNA mediated transformation
VS_RS14630	COG0242	peptide deformylase activity
VS_RS14640	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VS_RS14640	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VS_RS14645	COG0569	domain protein
VS_RS14650	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VS_RS14660	COG1272	protein, Hemolysin III
VS_RS14665	COG4326	sporulation control protein
VS_RS14670	COG3084	Protein conserved in bacteria
VS_RS14680	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
VS_RS14685	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VS_RS14695	COG0606	chelatase, subunit chli
VS_RS14705	COG3978	acetolactate synthase activity
VS_RS14710	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VS_RS14725	COG0583	DNA-binding transcription factor activity
VS_RS14730	COG2814	Major facilitator Superfamily
VS_RS14740	COG0355	proton-transporting ATP synthase activity, rotational mechanism
VS_RS14745	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
VS_RS14750	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
VS_RS14755	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
VS_RS14765	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
VS_RS14780	COG3312	ion transport
VS_RS14785	COG1475	DNA binding
VS_RS14790	COG1192	Involved in chromosome partitioning
VS_RS14830	COG1444	tRNA N-acetyltransferase activity
VS_RS14860	COG2204	response regulator
VS_RS14880	COG1262	PFAM Formylglycine-generating sulfatase enzyme
VS_RS14905	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VS_RS14920	COG4399	Belongs to the UPF0754 family
VS_RS14925	COG1132	(ABC) transporter
VS_RS14950	COG2194	sulfuric ester hydrolase activity
VS_RS14975	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
VS_RS14985	COG4145	pantothenate transmembrane transporter activity
VS_RS14990	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VS_RS14995	COG0800	Aldolase
VS_RS15010	COG2205	protein histidine kinase activity
VS_RS15015	COG0745	RESPONSE REGULATOR receiver
VS_RS15020	COG5001	Diguanylate cyclase
VS_RS15020	COG3300	MHYT domain
VS_RS15035	COG1522	sequence-specific DNA binding
VS_RS15045	COG1473	amidohydrolase
VS_RS15050	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VS_RS15060	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VS_RS15095	COG4175	Glycine betaine
VS_RS15095	COG0517	IMP dehydrogenase activity
VS_RS15100	COG1846	Transcriptional regulator
VS_RS15120	COG0456	acetyltransferase
VS_RS15125	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
VS_RS15135	COG0527	aspartate kinase activity
VS_RS15150	COG0110	maltose O-acetyltransferase activity
VS_RS15240	COG2015	COG2015, Alkyl sulfatase and related hydrolases
VS_RS15255	COG0346	lactoylglutathione lyase activity
VS_RS15265	COG2723	6-phospho-beta-galactosidase activity
VS_RS15270	COG1609	Transcriptional regulator
VS_RS15275	COG0110	maltose O-acetyltransferase activity
VS_RS15280	COG2814	Major facilitator Superfamily
VS_RS15285	COG0583	DNA-binding transcription factor activity
VS_RS15305	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
VS_RS15315	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VS_RS15345	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
VS_RS15350	COG1349	DNA-binding transcription factor activity
VS_RS15360	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
VS_RS15370	COG0583	DNA-binding transcription factor activity
VS_RS15375	COG0798	PFAM Bile acid sodium symporter
VS_RS15385	COG0561	phosphatase activity
VS_RS15395	COG3214	Protein conserved in bacteria
VS_RS15400	COG0583	DNA-binding transcription factor activity
VS_RS15435	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VS_RS15440	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
VS_RS15455	COG3623	hexulose-6-phosphate isomerase
VS_RS15460	COG1414	Transcriptional regulator
VS_RS15465	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
VS_RS15480	COG0561	phosphatase activity
VS_RS15490	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VS_RS15495	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VS_RS15500	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VS_RS15510	COG1929	Belongs to the glycerate kinase type-1 family
VS_RS15515	COG0753	catalase activity
VS_RS15520	COG4667	esterase of the alpha-beta hydrolase superfamily
VS_RS15525	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VS_RS15535	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VS_RS15540	COG0204	Acyl-transferase
VS_RS15545	COG2384	SAM-dependent methyltransferase
VS_RS15585	COG0366	Alpha amylase catalytic
VS_RS15640	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
VS_RS15645	COG1162	GTPase activity
VS_RS15655	COG1999	signal sequence binding
VS_RS15675	COG0058	SHG alpha-glucan phosphorylase activity
VS_RS15680	COG1640	4-alpha-glucanotransferase
VS_RS15685	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
VS_RS15695	COG1122	ATPase activity
VS_RS15705	COG1566	PFAM secretion protein HlyD family protein
VS_RS15720	COG3706	GGDEF domain
VS_RS15735	COG0813	purine-nucleoside phosphorylase activity
VS_RS15740	COG1388	LysM domain
VS_RS15740	COG1376	ErfK ybiS ycfS ynhG family protein
VS_RS15750	COG0513	Belongs to the DEAD box helicase family
VS_RS15755	COG3240	lipase activity
VS_RS15760	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
VS_RS15770	COG0840	transmembrane signaling receptor activity
VS_RS15780	COG0573	inorganic phosphate transmembrane transporter activity
VS_RS15785	COG0581	inorganic phosphate transmembrane transporter activity
VS_RS15790	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VS_RS15805	COG2304	oxidoreductase activity
VS_RS15810	COG2304	oxidoreductase activity
VS_RS15825	COG0714	Associated with various cellular activities
VS_RS15830	COG0840	transmembrane signaling receptor activity
VS_RS15840	COG3842	ATPase activity
VS_RS15850	COG1175	transmembrane transport
VS_RS15855	COG3833	ABC-type maltose transport systems, permease component
VS_RS15900	COG0668	transmembrane transport
VS_RS15905	COG0583	DNA-binding transcription factor activity
VS_RS15925	COG2239	Acts as a magnesium transporter
VS_RS15935	COG0387	Pfam Sodium calcium exchanger
VS_RS15940	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VS_RS15945	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VS_RS15955	COG2356	endonuclease I
VS_RS15970	COG1136	(ABC) transporter
VS_RS15975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VS_RS15980	COG5001	Diguanylate cyclase
VS_RS15980	COG3300	MHYT domain
VS_RS15995	COG1032	radical SAM domain protein
VS_RS16070	COG1012	belongs to the aldehyde dehydrogenase family
VS_RS16080	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VS_RS16105	COG0633	Ferredoxin
VS_RS16105	COG3217	Mosc domain protein beta barrel domain protein
VS_RS16155	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
VS_RS16160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VS_RS16170	COG0848	biopolymer transport protein
VS_RS16175	COG0811	peptide transport
VS_RS16180	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
VS_RS16190	COG3721	Heme iron utilization protein
VS_RS16195	COG0748	coenzyme F420 binding
VS_RS16200	COG0784	Response regulator, receiver
VS_RS16200	COG0835	chemotaxis
VS_RS16205	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VS_RS16210	COG0366	Alpha amylase catalytic
VS_RS16245	COG0739	heme binding
VS_RS16250	COG5001	Diguanylate cyclase
VS_RS16255	COG0583	DNA-binding transcription factor activity
VS_RS16260	COG2814	Major facilitator Superfamily
VS_RS16275	COG0697	spore germination
VS_RS16280	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VS_RS16290	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VS_RS16295	COG3037	sugar-specific permease SgaT UlaA
VS_RS16310	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VS_RS16335	COG0513	Belongs to the DEAD box helicase family
VS_RS16350	COG3706	GGDEF domain
VS_RS16355	COG1278	Cold shock
VS_RS16360	COG0402	S-adenosylhomocysteine deaminase activity
VS_RS16385	COG4413	Urea transporter
VS_RS16400	COG0531	amino acid
VS_RS16415	COG1280	lysine exporter protein (LysE YggA)
VS_RS16435	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VS_RS16475	COG2827	Endonuclease containing a URI domain
VS_RS16500	COG0443	Heat shock 70 kDa protein
VS_RS16510	COG0179	Fumarylacetoacetate (FAA) hydrolase
VS_RS16515	COG1280	lysine exporter protein (LysE YggA)
VS_RS16520	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VS_RS16525	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
VS_RS16525	COG1565	acr, cog1565
VS_RS16530	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
VS_RS16540	COG1845	cytochrome c oxidase, subunit III
VS_RS16565	COG0109	protoheme IX farnesyltransferase activity
VS_RS16580	COG3530	Putative quorum-sensing-regulated virulence factor
VS_RS16600	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
VS_RS16605	COG2944	sequence-specific DNA binding
VS_RS16625	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VS_RS16630	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VS_RS16640	COG0668	transmembrane transport
VS_RS16645	COG0569	domain protein
VS_RS16650	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VS_RS16655	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VS_RS16655	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VS_RS16660	COG1765	OsmC-like protein
VS_RS16665	COG2885	chlorophyll binding
VS_RS16685	COG1840	ABC-type Fe3 transport system, periplasmic component
VS_RS16690	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VS_RS16695	COG3842	ATPase activity
VS_RS16715	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
VS_RS16725	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VS_RS16730	COG3265	gluconokinase activity
VS_RS16735	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
VS_RS16745	COG1609	Transcriptional regulator
VS_RS16755	COG3104	oligopeptide transport
VS_RS16760	COG1760	l-serine dehydratase
VS_RS16775	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
VS_RS16795	COG1132	(ABC) transporter
VS_RS16800	COG1132	(ABC) transporter
VS_RS16810	COG0739	heme binding
VS_RS16815	COG0393	Putative heavy-metal-binding
VS_RS16830	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
VS_RS16855	COG0346	lactoylglutathione lyase activity
VS_RS16865	COG2211	Major facilitator Superfamily
VS_RS16870	COG0156	8-amino-7-oxononanoate synthase activity
VS_RS16885	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VS_RS16885	COG0475	glutathione-regulated potassium exporter activity
VS_RS16890	COG2249	NAD(P)H dehydrogenase (quinone) activity
VS_RS16910	COG1454	alcohol dehydrogenase
VS_RS16920	COG1011	Hydrolase
VS_RS16930	COG2203	Gaf domain
VS_RS16930	COG3706	GGDEF domain
VS_RS16930	COG4251	negative regulation of phosphorylation
VS_RS16930	COG5001	Diguanylate cyclase
VS_RS16950	COG2264	protein methyltransferase activity
VS_RS16955	COG1328	CTP reductase activity
VS_RS16960	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VS_RS16965	COG0583	DNA-binding transcription factor activity
VS_RS16980	COG1289	transmembrane transporter activity
VS_RS16985	COG0210	DNA helicase
VS_RS16995	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VS_RS17000	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
VS_RS17015	COG0583	DNA-binding transcription factor activity
VS_RS17035	COG4964	Belongs to the GSP D family
VS_RS17090	COG2203	Gaf domain
VS_RS17090	COG5001	Diguanylate cyclase
VS_RS17090	COG3706	GGDEF domain
VS_RS17090	COG4251	negative regulation of phosphorylation
VS_RS17095	COG2897	thiosulfate sulfurtransferase activity
VS_RS17125	COG0302	gtp cyclohydrolase
VS_RS17140	COG4681	YaeQ
VS_RS17145	COG1278	Cold shock
VS_RS17150	COG2133	pyrroloquinoline quinone binding
VS_RS17160	COG1120	ATPase activity
VS_RS17175	COG4774	siderophore transport
VS_RS17190	COG1024	Enoyl-CoA hydratase
VS_RS17205	COG1902	pentaerythritol trinitrate reductase activity
VS_RS17205	COG0446	pyridine nucleotide-disulphide oxidoreductase
VS_RS17220	COG1132	(ABC) transporter
VS_RS17245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VS_RS17250	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VS_RS17285	COG2824	Alkylphosphonate utilization operon protein PhnA
VS_RS17320	COG0765	amino acid transport
VS_RS17330	COG0765	amino acid transport
VS_RS17335	COG1126	abc transporter atp-binding protein
VS_RS17340	COG1979	alcohol dehydrogenase
VS_RS17345	COG2207	Transcriptional regulator
VS_RS17370	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VS_RS17375	COG3059	membrane
VS_RS17385	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VS_RS17395	COG2199	diguanylate cyclase activity
VS_RS17410	COG1686	Belongs to the peptidase S11 family
VS_RS17420	COG0583	DNA-binding transcription factor activity
VS_RS17430	COG0564	pseudouridine synthase activity
VS_RS17440	COG2130	NADP-dependent
VS_RS17445	COG1309	transcriptional regulator
VS_RS17450	COG0545	Peptidyl-prolyl cis-trans isomerase
VS_RS17470	COG3604	Transcriptional regulator
VS_RS17475	COG1017	nitric oxide dioxygenase activity
VS_RS17475	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VS_RS17485	COG0038	chloride channel
VS_RS17490	COG0523	cobalamin synthesis protein
VS_RS17495	COG0513	Belongs to the DEAD box helicase family
VS_RS17500	COG1280	lysine exporter protein (LysE YggA)
VS_RS17570	COG0183	Belongs to the thiolase family
VS_RS17595	COG0745	RESPONSE REGULATOR receiver
VS_RS17620	COG3005	denitrification pathway
VS_RS17645	COG3850	Histidine kinase
VS_RS17650	COG2197	response regulator
VS_RS17655	COG3069	C4-dicarboxylate transmembrane transporter activity
VS_RS17660	COG2188	Transcriptional regulator
VS_RS17665	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VS_RS17665	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VS_RS17665	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VS_RS17670	COG0383	alpha-mannosidase activity
VS_RS17675	COG1929	Belongs to the glycerate kinase type-1 family
VS_RS17715	COG1012	belongs to the aldehyde dehydrogenase family
VS_RS17730	COG4977	sequence-specific DNA binding
VS_RS17730	COG1917	Cupin 2, conserved barrel domain protein
VS_RS17755	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
VS_RS17760	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
VS_RS17770	COG4533	DNA binding
VS_RS17815	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
VS_RS17820	COG0494	nUDIX hydrolase
VS_RS17830	COG2425	protein containing a von Willebrand factor type A (vWA) domain
VS_RS17895	COG1858	cytochrome C peroxidase
VS_RS17900	COG1858	cytochrome C peroxidase
VS_RS17945	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VS_RS17955	COG2116	formate transmembrane transporter activity
VS_RS17975	COG0745	RESPONSE REGULATOR receiver
VS_RS17980	COG2205	protein histidine kinase activity
VS_RS17985	COG1301	dicarboxylic acid transport
VS_RS17990	COG4774	siderophore transport
VS_RS18000	COG0811	peptide transport
VS_RS18005	COG0811	peptide transport
VS_RS18010	COG0848	biopolymer transport protein
VS_RS18055	COG0803	Belongs to the bacterial solute-binding protein 9 family
VS_RS18060	COG1121	(ABC) transporter
VS_RS18065	COG1321	iron dependent repressor
VS_RS18065	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VS_RS18090	COG0534	Mate efflux family protein
VS_RS18125	COG3118	belongs to the thioredoxin family
VS_RS18130	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VS_RS18155	COG1328	CTP reductase activity
VS_RS18160	COG0602	queuosine metabolic process
VS_RS18180	COG0189	ligase activity
VS_RS18180	COG4067	protein conserved in archaea
VS_RS18185	COG0488	(ABC) transporter
VS_RS18210	COG0725	ABC transporter, periplasmic molybdate-binding protein
VS_RS18215	COG4149	molybdate abc transporter
VS_RS18220	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
VS_RS18230	COG4251	negative regulation of phosphorylation
VS_RS18230	COG5001	Diguanylate cyclase
VS_RS18230	COG3706	GGDEF domain
VS_RS18230	COG2203	Gaf domain
VS_RS18240	COG3706	GGDEF domain
VS_RS18255	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
VS_RS18260	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
VS_RS18285	COG3706	GGDEF domain
VS_RS18295	COG0023	Translation Initiation Factor
VS_RS18315	COG3266	domain, Protein
VS_RS18320	COG0045	succinate-CoA ligase (ADP-forming) activity
VS_RS18320	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VS_RS18320	COG1042	CoA-binding domain protein
VS_RS18325	COG0583	DNA-binding transcription factor activity
VS_RS18330	COG4771	TonB-dependent receptor
VS_RS18330	COG1629	transport
VS_RS18345	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
VS_RS18350	COG1984	allophanate hydrolase subunit 2
VS_RS18360	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
VS_RS18365	COG4181	ATPase activity
VS_RS18375	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VS_RS18380	COG5001	Diguanylate cyclase
VS_RS18380	COG1716	ATPase activity
VS_RS18390	COG0768	penicillin binding
VS_RS18395	COG0484	heat shock protein binding
VS_RS18420	COG4533	DNA binding
VS_RS18430	COG2050	protein possibly involved in aromatic compounds catabolism
VS_RS18435	COG0501	Belongs to the peptidase M48B family
VS_RS18445	COG2067	long-chain fatty acid transport protein
VS_RS18450	COG2267	carboxylic ester hydrolase activity
VS_RS18460	COG0513	Belongs to the DEAD box helicase family
VS_RS18475	COG0861	Integral membrane protein TerC family
VS_RS18490	COG3593	DNA synthesis involved in DNA repair
VS_RS18500	COG0583	DNA-binding transcription factor activity
VS_RS18505	COG2116	formate transmembrane transporter activity
VS_RS18510	COG2353	YceI-like domain
VS_RS18530	COG2200	EAL domain
VS_RS18555	COG0513	Belongs to the DEAD box helicase family
VS_RS18565	COG0814	amino acid
VS_RS18570	COG0840	transmembrane signaling receptor activity
VS_RS18575	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VS_RS18580	COG0784	Response regulator, receiver
VS_RS18580	COG3437	response regulator, receiver
VS_RS18595	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VS_RS18605	COG3706	GGDEF domain
VS_RS18610	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VS_RS18690	COG3547	Transposase (IS116 IS110 IS902 family)
VS_RS18715	COG0534	Mate efflux family protein
VS_RS18750	COG3048	D-serine ammonia-lyase activity
VS_RS18760	COG1881	PFAM PEBP family protein
VS_RS18765	COG5002	protein histidine kinase activity
VS_RS18830	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VS_RS18835	COG2205	protein histidine kinase activity
VS_RS18835	COG0784	Response regulator, receiver
VS_RS18840	COG1538	Outer membrane efflux protein
VS_RS18845	COG1132	(ABC) transporter
VS_RS18860	COG5002	protein histidine kinase activity
VS_RS18860	COG2205	protein histidine kinase activity
VS_RS18860	COG0784	Response regulator, receiver
VS_RS18880	COG0641	radical SAM
VS_RS18895	COG0583	DNA-binding transcription factor activity
VS_RS18925	COG0714	Associated with various cellular activities
VS_RS18935	COG3119	arylsulfatase activity
VS_RS18940	COG3119	arylsulfatase activity
VS_RS18950	COG0456	acetyltransferase
VS_RS18955	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
VS_RS18975	COG0384	phenazine biosynthesis protein PhzF
VS_RS18980	COG1280	lysine exporter protein (LysE YggA)
VS_RS18990	COG3300	MHYT domain
VS_RS18990	COG5001	Diguanylate cyclase
VS_RS19010	COG3278	Belongs to the heme-copper respiratory oxidase family
VS_RS19050	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VS_RS19060	COG1012	belongs to the aldehyde dehydrogenase family
VS_RS19070	COG0583	DNA-binding transcription factor activity
VS_RS19080	COG0356	it plays a direct role in the translocation of protons across the membrane
VS_RS19105	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
VS_RS19115	COG0355	proton-transporting ATP synthase activity, rotational mechanism
VS_RS19135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VS_RS19140	COG1538	Outer membrane efflux protein
VS_RS19180	COG1228	amidohydrolase
VS_RS19195	COG4172	Belongs to the ABC transporter superfamily
VS_RS19200	COG4239	(ABC) transporter, permease
VS_RS19205	COG4174	ABC transporter (Permease)
VS_RS19210	COG4166	transmembrane transport
VS_RS19230	COG1869	D-ribose catabolic process
VS_RS19235	COG1129	ABC transporter
VS_RS19240	COG1172	Belongs to the binding-protein-dependent transport system permease family
VS_RS19245	COG1879	ABC-type sugar transport system periplasmic component
VS_RS19250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VS_RS19255	COG1609	Transcriptional regulator
VS_RS19270	COG0330	HflC and HflK could
VS_RS19465	COG1522	sequence-specific DNA binding
VS_RS19500	COG0515	serine threonine protein kinase
VS_RS19500	COG2815	serine threonine protein kinase
VS_RS19525	COG3501	Rhs element vgr protein
VS_RS19555	COG2885	chlorophyll binding
VS_RS19620	COG0739	heme binding
VS_RS19630	COG0243	molybdopterin cofactor binding
VS_RS19635	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VS_RS19645	COG2223	nitrite transmembrane transporter activity
VS_RS19650	COG0515	serine threonine protein kinase
VS_RS19650	COG2815	serine threonine protein kinase
VS_RS19655	COG1609	Transcriptional regulator
VS_RS19660	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VS_RS19660	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
VS_RS19665	COG1105	Belongs to the carbohydrate kinase PfkB family
VS_RS19670	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VS_RS19670	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
VS_RS19670	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VS_RS19680	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VS_RS19705	COG0745	RESPONSE REGULATOR receiver
VS_RS19720	COG0625	glutathione transferase activity
VS_RS19755	COG1879	ABC-type sugar transport system periplasmic component
VS_RS19765	COG0840	transmembrane signaling receptor activity
VS_RS19770	COG1522	sequence-specific DNA binding
VS_RS19790	COG2814	Major facilitator Superfamily
VS_RS19795	COG0583	DNA-binding transcription factor activity
VS_RS19800	COG2205	protein histidine kinase activity
VS_RS19800	COG0784	Response regulator, receiver
VS_RS19805	COG3437	response regulator, receiver
VS_RS19810	COG4604	ABC transporter, ATP-binding protein
VS_RS19815	COG4605	iron ion homeostasis
VS_RS19820	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VS_RS19825	COG4607	ABC-type enterochelin transport system periplasmic component
VS_RS19845	COG0628	permease
VS_RS19855	COG1566	PFAM secretion protein HlyD family protein
VS_RS19875	COG0583	DNA-binding transcription factor activity
VS_RS19890	COG0840	transmembrane signaling receptor activity
VS_RS19900	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
VS_RS19905	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VS_RS19910	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VS_RS19915	COG1116	anion transmembrane transporter activity
VS_RS19920	COG0351	phosphomethylpyrimidine kinase
VS_RS19925	COG0697	spore germination
VS_RS19950	COG0625	glutathione transferase activity
VS_RS19975	COG3646	Phage regulatory protein
VS_RS20020	COG4566	intracellular signal transduction
VS_RS20030	COG0534	Mate efflux family protein
VS_RS20035	COG0583	DNA-binding transcription factor activity
VS_RS20075	COG1120	ATPase activity
VS_RS20080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VS_RS20085	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VS_RS20090	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
VS_RS20095	COG4772	TonB-dependent receptor
VS_RS20120	COG4264	IucA IucC family
VS_RS20125	COG0019	diaminopimelate decarboxylase activity
VS_RS20135	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
VS_RS20140	COG0513	Belongs to the DEAD box helicase family
VS_RS20160	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
VS_RS20200	COG0667	Aldo Keto reductase
VS_RS20205	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VS_RS20210	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
VS_RS20215	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
VS_RS20230	COG0778	Nitroreductase
VS_RS20235	COG0513	Belongs to the DEAD box helicase family
VS_RS20245	COG2176	DNA-directed DNA polymerase activity
VS_RS20260	COG0513	Belongs to the DEAD box helicase family
VS_RS20265	COG4989	oxidoreductase activity
VS_RS20305	COG0668	transmembrane transport
VS_RS20315	COG4232	protein-disulfide reductase activity
VS_RS20320	COG3118	belongs to the thioredoxin family
VS_RS20330	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
VS_RS20335	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VS_RS20340	COG2205	protein histidine kinase activity
VS_RS20345	COG0745	RESPONSE REGULATOR receiver
VS_RS20355	COG5001	Diguanylate cyclase
VS_RS20360	COG2199	diguanylate cyclase activity
VS_RS20360	COG2200	EAL domain
VS_RS20360	COG2202	Pas domain
VS_RS20365	COG2186	Transcriptional regulator
VS_RS20370	COG1131	(ABC) transporter
VS_RS20400	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VS_RS20400	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VS_RS20410	COG0564	pseudouridine synthase activity
VS_RS20420	COG2814	Major facilitator Superfamily
VS_RS20430	COG3708	Transcriptional regulator
VS_RS20430	COG2207	Transcriptional regulator
VS_RS20450	COG4533	DNA binding
VS_RS20460	COG4067	protein conserved in archaea
VS_RS20460	COG0189	ligase activity
VS_RS20480	COG1175	transmembrane transport
VS_RS20485	COG0395	ABC-type sugar transport system, permease component
VS_RS20490	COG3842	ATPase activity
VS_RS20495	COG0584	glycerophosphoryl diester phosphodiesterase
VS_RS20520	COG0673	inositol 2-dehydrogenase activity
VS_RS20525	COG2999	glutathione oxidoreductase activity
VS_RS20540	COG0534	Mate efflux family protein
VS_RS20545	COG2964	Protein conserved in bacteria
VS_RS20560	COG0446	pyridine nucleotide-disulphide oxidoreductase
VS_RS20630	COG1215	transferase activity, transferring glycosyl groups
VS_RS20650	COG1595	DNA-templated transcription, initiation
VS_RS20655	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
VS_RS20670	COG0840	transmembrane signaling receptor activity
VS_RS20690	COG4166	transmembrane transport
VS_RS20700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VS_RS20705	COG4172	Belongs to the ABC transporter superfamily
VS_RS20715	COG0583	DNA-binding transcription factor activity
VS_RS20720	COG2910	NAD(P)H-binding
VS_RS20730	COG1028	Short-chain dehydrogenase reductase Sdr
VS_RS20735	COG1733	regulation of RNA biosynthetic process
VS_RS20740	COG0583	DNA-binding transcription factor activity
VS_RS20745	COG4221	oxidoreductase activity
VS_RS20750	COG3047	cAMP biosynthetic process
VS_RS20755	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
VS_RS20770	COG3639	organic phosphonate transmembrane transporter activity
VS_RS20775	COG3639	organic phosphonate transmembrane transporter activity
VS_RS20780	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
VS_RS20825	COG4948	Mandelate Racemase Muconate Lactonizing
VS_RS20835	COG0583	DNA-binding transcription factor activity
VS_RS20845	COG0366	Alpha amylase catalytic
VS_RS20860	COG0583	DNA-binding transcription factor activity
VS_RS20885	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VS_RS20900	COG0814	amino acid
VS_RS20905	COG1846	Transcriptional regulator
VS_RS20910	COG1764	response to oxidative stress
VS_RS20915	COG0840	transmembrane signaling receptor activity
VS_RS20920	COG1309	transcriptional regulator
VS_RS20925	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VS_RS20930	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VS_RS20940	COG2207	Transcriptional regulator
VS_RS20945	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VS_RS20945	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VS_RS20945	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VS_RS20960	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VS_RS20965	COG4166	transmembrane transport
VS_RS20980	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
VS_RS20985	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
VS_RS21005	COG1280	lysine exporter protein (LysE YggA)
VS_RS21015	COG1012	belongs to the aldehyde dehydrogenase family
VS_RS21020	COG3284	Transcriptional regulator
VS_RS21025	COG0840	transmembrane signaling receptor activity
VS_RS21030	COG0583	DNA-binding transcription factor activity
VS_RS21035	COG0625	glutathione transferase activity
VS_RS21040	COG3655	Transcriptional regulator
VS_RS21080	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VS_RS21085	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VS_RS21090	COG1418	mRNA catabolic process
VS_RS21125	COG1846	Transcriptional regulator
VS_RS21130	COG0697	spore germination
VS_RS21195	COG1067	ATP-dependent peptidase activity
VS_RS21205	COG4172	Belongs to the ABC transporter superfamily
VS_RS21225	COG1609	Transcriptional regulator
VS_RS21240	COG3459	Glycosyltransferase 36 associated
VS_RS21245	COG3842	ATPase activity
VS_RS21250	COG2723	6-phospho-beta-galactosidase activity
VS_RS21255	COG0395	ABC-type sugar transport system, permease component
VS_RS21285	COG1505	serine-type exopeptidase activity
VS_RS21290	COG0583	DNA-binding transcription factor activity
VS_RS21295	COG1620	l-lactate permease
VS_RS21300	COG1304	FMN binding
VS_RS21315	COG2207	Transcriptional regulator
VS_RS21315	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VS_RS21320	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VS_RS21360	COG1741	Belongs to the pirin family
VS_RS21380	COG0596	Alpha beta hydrolase
VS_RS21420	COG3788	relative of glutathione S-transferase, MAPEG superfamily
VS_RS21425	COG0700	Nucleoside recognition
VS_RS21430	COG3366	ferrous iron transmembrane transporter activity
VS_RS21435	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
VS_RS21445	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
VS_RS21450	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
VS_RS21490	COG0446	pyridine nucleotide-disulphide oxidoreductase
VS_RS21495	COG0786	glutamate:sodium symporter activity
VS_RS21515	COG1942	4-Oxalocrotonate Tautomerase
VS_RS21525	COG1595	DNA-templated transcription, initiation
VS_RS21530	COG3806	Anti-sigma factor
VS_RS21540	COG0415	Belongs to the DNA photolyase family
VS_RS21565	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
VS_RS21590	COG4221	oxidoreductase activity
VS_RS21595	COG0724	RNA recognition motif
VS_RS21605	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
VS_RS21620	COG1263	PTS System
VS_RS21620	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VS_RS21635	COG2205	protein histidine kinase activity
VS_RS21650	COG1028	Short-chain dehydrogenase reductase Sdr
VS_RS21655	COG2814	Major facilitator Superfamily
VS_RS21660	COG1902	pentaerythritol trinitrate reductase activity
VS_RS21670	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VS_RS21675	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VS_RS21685	COG0612	Peptidase, M16
VS_RS21690	COG0612	Peptidase, M16
VS_RS21695	COG3279	Response regulator of the LytR AlgR family
VS_RS21700	COG3275	phosphorelay sensor kinase activity
VS_RS21715	COG4591	ABC-type transport system involved in lipoprotein release permease component
VS_RS21730	COG0583	DNA-binding transcription factor activity
VS_RS21745	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
VS_RS21750	COG0583	DNA-binding transcription factor activity
VS_RS21755	COG0840	transmembrane signaling receptor activity
VS_RS21760	COG2084	Dehydrogenase
VS_RS21800	COG3186	Phenylalanine-4-hydroxylase
VS_RS21805	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VS_RS21845	COG0625	glutathione transferase activity
VS_RS21855	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
VS_RS21880	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VS_RS21880	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
VS_RS21890	COG0444	Belongs to the ABC transporter superfamily
VS_RS21895	COG4608	Belongs to the ABC transporter superfamily
VS_RS22110	COG4890	Cyd operon protein YbgT
VS_RS22140	COG1401	restriction endodeoxyribonuclease activity
VS_RS22300	COG0456	acetyltransferase
VS_RS22390	COG3140	Belongs to the UPF0181 family