locus-tag	class	description
A6E01_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A6E01_RS00020	COG1126	abc transporter atp-binding protein
A6E01_RS00025	COG0230	Belongs to the bacterial ribosomal protein bL34 family
A6E01_RS00035	COG0706	membrane insertase activity
A6E01_RS00040	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A6E01_RS00045	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A6E01_RS00050	COG0445	tRNA wobble uridine modification
A6E01_RS00055	COG0357	Ribosomal RNA small subunit methyltransferase G
A6E01_RS00060	COG1192	Involved in chromosome partitioning
A6E01_RS00065	COG1475	DNA binding
A6E01_RS00070	COG3312	ion transport
A6E01_RS00085	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A6E01_RS00095	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A6E01_RS00100	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A6E01_RS00110	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A6E01_RS00120	COG0765	amino acid transport
A6E01_RS00130	COG2814	Major facilitator Superfamily
A6E01_RS00135	COG0583	DNA-binding transcription factor activity
A6E01_RS00145	COG0129	dihydroxy-acid dehydratase activity
A6E01_RS00150	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A6E01_RS00155	COG3978	acetolactate synthase activity
A6E01_RS00165	COG0606	chelatase, subunit chli
A6E01_RS00170	COG0204	Acyl-transferase
A6E01_RS00175	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A6E01_RS00180	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A6E01_RS00190	COG3084	Protein conserved in bacteria
A6E01_RS00195	COG4326	sporulation control protein
A6E01_RS00200	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A6E01_RS00205	COG0569	domain protein
A6E01_RS00210	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A6E01_RS00210	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A6E01_RS00225	COG0758	DNA mediated transformation
A6E01_RS00230	COG2922	Belongs to the Smg family
A6E01_RS00235	COG0551	DNA topoisomerase type I activity
A6E01_RS00240	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A6E01_RS00245	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A6E01_RS00250	COG0009	L-threonylcarbamoyladenylate synthase
A6E01_RS00255	COG0408	coproporphyrinogen oxidase activity
A6E01_RS00260	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A6E01_RS00270	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A6E01_RS00315	COG3071	HemY protein
A6E01_RS00320	COG2959	enzyme of heme biosynthesis
A6E01_RS00340	COG1965	Belongs to the frataxin family
A6E01_RS00345	COG0019	diaminopimelate decarboxylase activity
A6E01_RS00350	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A6E01_RS00360	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
A6E01_RS00365	COG1011	Hydrolase
A6E01_RS00370	COG3148	PFAM DTW domain containing protein
A6E01_RS00380	COG0561	phosphatase activity
A6E01_RS00385	COG2267	carboxylic ester hydrolase activity
A6E01_RS00390	COG1280	lysine exporter protein (LysE YggA)
A6E01_RS00395	COG0640	Transcriptional regulator
A6E01_RS00400	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A6E01_RS00440	COG0747	negative chemotaxis
A6E01_RS00445	COG0601	transmembrane transport
A6E01_RS00450	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6E01_RS00460	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6E01_RS00465	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
A6E01_RS00470	COG0339	signal peptide processing
A6E01_RS00475	COG1522	sequence-specific DNA binding
A6E01_RS00480	COG0742	ribosomal rna small subunit methyltransferase
A6E01_RS00490	COG0589	response to stress
A6E01_RS00495	COG1528	Iron-storage protein
A6E01_RS00505	COG2081	HI0933 family
A6E01_RS00530	COG4608	Belongs to the ABC transporter superfamily
A6E01_RS00535	COG0444	Belongs to the ABC transporter superfamily
A6E01_RS00550	COG4166	transmembrane transport
A6E01_RS00565	COG2226	methyltransferase
A6E01_RS00575	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A6E01_RS00580	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A6E01_RS00585	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A6E01_RS00590	COG0805	protein transport
A6E01_RS00595	COG0084	hydrolase, TatD family'
A6E01_RS00610	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6E01_RS00610	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6E01_RS00615	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A6E01_RS00655	COG3852	Histidine kinase
A6E01_RS00660	COG0174	glutamine synthetase
A6E01_RS00665	COG1217	gtp-binding protein TYPA
A6E01_RS00675	COG1490	D-aminoacyl-tRNA deacylase activity
A6E01_RS00680	COG0456	acetyltransferase
A6E01_RS00700	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A6E01_RS00705	COG3031	protein transport across the cell outer membrane
A6E01_RS00715	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A6E01_RS00720	COG1459	type II secretion system
A6E01_RS00725	COG2165	general secretion pathway protein
A6E01_RS00730	COG2165	general secretion pathway protein
A6E01_RS00735	COG2165	general secretion pathway protein
A6E01_RS00740	COG4795	General secretion pathway protein
A6E01_RS00745	COG3156	type II secretion system protein K
A6E01_RS00750	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
A6E01_RS00755	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
A6E01_RS00765	COG0494	nUDIX hydrolase
A6E01_RS00770	COG1218	3'(2'),5'-bisphosphate nucleotidase
A6E01_RS00780	COG1040	competence protein
A6E01_RS00785	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
A6E01_RS00785	COG0316	Belongs to the HesB IscA family
A6E01_RS00800	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A6E01_RS00805	COG4067	protein conserved in archaea
A6E01_RS00805	COG0189	ligase activity
A6E01_RS00810	COG2183	response to ionizing radiation
A6E01_RS00815	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A6E01_RS00820	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A6E01_RS00825	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A6E01_RS00830	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A6E01_RS00845	COG0438	transferase activity, transferring glycosyl groups
A6E01_RS00855	COG0859	PFAM glycosyl transferase family 9
A6E01_RS00860	COG3642	lipopolysaccharide core region biosynthetic process
A6E01_RS00865	COG1519	Transferase
A6E01_RS00875	COG0438	transferase activity, transferring glycosyl groups
A6E01_RS00890	COG1086	Polysaccharide biosynthesis protein
A6E01_RS00895	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A6E01_RS00900	COG1083	cytidylyl-transferase
A6E01_RS00910	COG2089	acid synthase
A6E01_RS00925	COG0859	PFAM glycosyl transferase family 9
A6E01_RS00930	COG3307	-O-antigen
A6E01_RS00935	COG1560	Kdo2-lipid A biosynthetic process
A6E01_RS00955	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
A6E01_RS00960	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A6E01_RS00970	COG1609	Transcriptional regulator
A6E01_RS00975	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A6E01_RS00980	COG0254	rRNA binding
A6E01_RS00985	COG0281	malic enzyme
A6E01_RS00990	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
A6E01_RS00995	COG0626	cystathionine gamma-synthase activity
A6E01_RS01000	COG0527	aspartate kinase activity
A6E01_RS01000	COG0460	homoserine dehydrogenase
A6E01_RS01005	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A6E01_RS01010	COG1695	Transcriptional regulator
A6E01_RS01015	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
A6E01_RS01020	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A6E01_RS01025	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A6E01_RS01030	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A6E01_RS01040	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
A6E01_RS01040	COG0165	Argininosuccinate lyase
A6E01_RS01045	COG0251	oxidation-reduction process
A6E01_RS01050	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6E01_RS01055	COG0678	peroxiredoxin activity
A6E01_RS01055	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A6E01_RS01060	COG0583	DNA-binding transcription factor activity
A6E01_RS01065	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A6E01_RS01105	COG0338	D12 class N6 adenine-specific DNA methyltransferase
A6E01_RS01110	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A6E01_RS01115	COG0546	phosphoglycolate phosphatase activity
A6E01_RS01120	COG0180	Tryptophanyl-tRNA synthetase
A6E01_RS01140	COG1012	belongs to the aldehyde dehydrogenase family
A6E01_RS01155	COG3954	Phosphoribulokinase
A6E01_RS01165	COG0429	hydrolase of the alpha beta-hydrolase fold
A6E01_RS01175	COG0488	(ABC) transporter
A6E01_RS01180	COG2249	NAD(P)H dehydrogenase (quinone) activity
A6E01_RS01195	COG1047	Peptidyl-prolyl cis-trans
A6E01_RS01200	COG1446	asparaginase
A6E01_RS01210	COG0545	Peptidyl-prolyl cis-trans isomerase
A6E01_RS01215	COG2964	Protein conserved in bacteria
A6E01_RS01225	COG2923	Belongs to the DsrF TusC family
A6E01_RS01245	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A6E01_RS01260	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A6E01_RS01265	COG0088	Forms part of the polypeptide exit tunnel
A6E01_RS01270	COG0089	rRNA binding
A6E01_RS01275	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A6E01_RS01280	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A6E01_RS01285	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A6E01_RS01295	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A6E01_RS01305	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A6E01_RS01310	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A6E01_RS01320	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A6E01_RS01330	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A6E01_RS01335	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A6E01_RS01350	COG1841	ribosomal large subunit assembly
A6E01_RS01355	COG0200	Binds to the 23S rRNA
A6E01_RS01360	COG0201	protein transport
A6E01_RS01365	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A6E01_RS01370	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A6E01_RS01385	COG0202	RNA polymerase activity
A6E01_RS01390	COG0203	ribosomal protein L17
A6E01_RS01405	COG0545	Peptidyl-prolyl cis-trans isomerase
A6E01_RS01410	COG3061	Opacity-associated protein A
A6E01_RS01410	COG3266	domain, Protein
A6E01_RS01420	COG1648	precorrin-2 dehydrogenase activity
A6E01_RS01420	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A6E01_RS01445	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
A6E01_RS01450	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6E01_RS01455	COG0729	surface antigen
A6E01_RS01465	COG2105	PFAM AIG2 family protein
A6E01_RS01470	COG3040	lipid binding
A6E01_RS01480	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A6E01_RS01485	COG0163	prenyltransferase activity
A6E01_RS01490	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
A6E01_RS01495	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A6E01_RS01500	COG0564	pseudouridine synthase activity
A6E01_RS01505	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A6E01_RS01510	COG0589	response to stress
A6E01_RS01520	COG2358	TRAP transporter, solute receptor (TAXI family
A6E01_RS01525	COG1438	arginine binding
A6E01_RS01530	COG0039	L-malate dehydrogenase activity
A6E01_RS01540	COG0142	geranyltranstransferase activity
A6E01_RS01545	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A6E01_RS01560	COG1289	transmembrane transporter activity
A6E01_RS01565	COG3610	response to peptide
A6E01_RS01570	COG3610	response to peptide
A6E01_RS01580	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A6E01_RS01585	COG2967	ApaG domain
A6E01_RS01590	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A6E01_RS01595	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A6E01_RS01605	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
A6E01_RS01610	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A6E01_RS01625	COG0066	3-isopropylmalate dehydratase activity
A6E01_RS01635	COG0473	3-isopropylmalate dehydrogenase activity
A6E01_RS01670	COG0583	DNA-binding transcription factor activity
A6E01_RS01675	COG1022	Amp-dependent synthetase and ligase
A6E01_RS01680	COG0028	Belongs to the TPP enzyme family
A6E01_RS01685	COG0440	acetolactate synthase activity
A6E01_RS01690	COG0469	pyruvate kinase activity
A6E01_RS01695	COG0673	inositol 2-dehydrogenase activity
A6E01_RS01710	COG2015	COG2015, Alkyl sulfatase and related hydrolases
A6E01_RS01730	COG0534	Mate efflux family protein
A6E01_RS01755	COG2116	formate transmembrane transporter activity
A6E01_RS01760	COG1609	Transcriptional regulator
A6E01_RS01765	COG0129	dihydroxy-acid dehydratase activity
A6E01_RS01770	COG3265	gluconokinase activity
A6E01_RS01780	COG0800	Aldolase
A6E01_RS01785	COG2814	Major facilitator Superfamily
A6E01_RS01790	COG0583	DNA-binding transcription factor activity
A6E01_RS01795	COG3448	diguanylate cyclase activity
A6E01_RS01795	COG4175	Glycine betaine
A6E01_RS01800	COG4176	ABC-type proline glycine betaine transport system permease component
A6E01_RS01840	COG0358	DNA primase activity
A6E01_RS01845	COG1610	YqeY-like protein
A6E01_RS01855	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A6E01_RS01865	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A6E01_RS01870	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A6E01_RS01875	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A6E01_RS01880	COG1968	undecaprenyl-diphosphatase activity
A6E01_RS01885	COG0617	tRNA 3'-terminal CCA addition
A6E01_RS01890	COG3267	Type II secretory pathway component ExeA
A6E01_RS01890	COG3409	Peptidoglycan-binding domain 1 protein
A6E01_RS01900	COG4991	sh3 domain protein
A6E01_RS01905	COG0306	phosphate transporter
A6E01_RS01910	COG1392	Phosphate transport regulator
A6E01_RS01915	COG3025	triphosphatase activity
A6E01_RS01930	COG1538	Outer membrane efflux protein
A6E01_RS01935	COG0494	nUDIX hydrolase
A6E01_RS01940	COG3151	Protein conserved in bacteria
A6E01_RS01950	COG3150	esterase
A6E01_RS01955	COG0187	DNA topoisomerase II activity
A6E01_RS01965	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A6E01_RS01970	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A6E01_RS01980	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
A6E01_RS01990	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A6E01_RS01995	COG0723	plastoquinol--plastocyanin reductase activity
A6E01_RS02000	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A6E01_RS02005	COG2857	Cytochrome c1
A6E01_RS02010	COG0625	glutathione transferase activity
A6E01_RS02015	COG2969	positive regulation of protein catabolic process
A6E01_RS02020	COG2823	Periplasmic or secreted lipoprotein
A6E01_RS02025	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A6E01_RS02030	COG0792	nuclease activity
A6E01_RS02035	COG3107	peptidoglycan biosynthetic process
A6E01_RS02040	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A6E01_RS02055	COG3116	cell division
A6E01_RS02060	COG0768	penicillin binding
A6E01_RS02065	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A6E01_RS02070	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A6E01_RS02075	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A6E01_RS02080	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A6E01_RS02085	COG0772	Belongs to the SEDS family
A6E01_RS02090	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A6E01_RS02100	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A6E01_RS02105	COG0849	cell division
A6E01_RS02110	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A6E01_RS02115	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
A6E01_RS02130	COG0494	nUDIX hydrolase
A6E01_RS02140	COG0505	Belongs to the CarA family
A6E01_RS02145	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A6E01_RS02150	COG0730	response to heat
A6E01_RS02155	COG0583	DNA-binding transcription factor activity
A6E01_RS02160	COG2860	membrane
A6E01_RS02165	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A6E01_RS02175	COG0493	'glutamate synthase
A6E01_RS02180	COG0070	glutamate synthase
A6E01_RS02180	COG0069	glutamate synthase activity
A6E01_RS02180	COG0067	glutamate synthase
A6E01_RS02190	COG0067	glutamate synthase
A6E01_RS02190	COG0070	glutamate synthase
A6E01_RS02190	COG0069	glutamate synthase activity
A6E01_RS02195	COG1242	4 iron, 4 sulfur cluster binding
A6E01_RS02200	COG2198	Histidine kinase
A6E01_RS02200	COG0784	Response regulator, receiver
A6E01_RS02200	COG5002	protein histidine kinase activity
A6E01_RS02210	COG0745	RESPONSE REGULATOR receiver
A6E01_RS02225	COG0083	homoserine kinase activity
A6E01_RS02230	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A6E01_RS02245	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A6E01_RS02260	COG1115	amino acid carrier protein
A6E01_RS02265	COG3022	response to hydroperoxide
A6E01_RS02280	COG0513	Belongs to the DEAD box helicase family
A6E01_RS02295	COG0716	FMN binding
A6E01_RS02300	COG4974	Belongs to the 'phage' integrase family
A6E01_RS02305	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A6E01_RS02310	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A6E01_RS02315	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A6E01_RS02320	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A6E01_RS02325	COG0517	IMP dehydrogenase activity
A6E01_RS02335	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A6E01_RS02340	COG0343	queuine tRNA-ribosyltransferase activity
A6E01_RS02345	COG1862	Preprotein translocase
A6E01_RS02350	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6E01_RS02355	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6E01_RS02360	COG1047	Peptidyl-prolyl cis-trans
A6E01_RS02365	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A6E01_RS02370	COG1966	Carbon starvation protein
A6E01_RS02380	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
A6E01_RS02395	COG3279	Response regulator of the LytR AlgR family
A6E01_RS02400	COG3275	phosphorelay sensor kinase activity
A6E01_RS02405	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A6E01_RS02410	COG0287	Prephenate dehydrogenase
A6E01_RS02410	COG1605	Chorismate mutase
A6E01_RS02415	COG0488	(ABC) transporter
A6E01_RS02425	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
A6E01_RS02430	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
A6E01_RS02435	COG1605	Chorismate mutase
A6E01_RS02435	COG0077	Prephenate dehydratase
A6E01_RS02440	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A6E01_RS02445	COG0739	heme binding
A6E01_RS02445	COG0741	lytic transglycosylase activity
A6E01_RS02445	COG1196	nuclear chromosome segregation
A6E01_RS02450	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A6E01_RS02455	COG0564	pseudouridine synthase activity
A6E01_RS02465	COG0542	response to heat
A6E01_RS02520	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A6E01_RS02525	COG0826	peptidase U32
A6E01_RS02530	COG2974	May be involved in recombination
A6E01_RS02535	COG0745	RESPONSE REGULATOR receiver
A6E01_RS02540	COG5002	protein histidine kinase activity
A6E01_RS02550	COG0248	Ppx GppA phosphatase
A6E01_RS02555	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A6E01_RS02560	COG0573	inorganic phosphate transmembrane transporter activity
A6E01_RS02565	COG0573	inorganic phosphate transmembrane transporter activity
A6E01_RS02570	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A6E01_RS02575	COG0704	Plays a role in the regulation of phosphate uptake
A6E01_RS02580	COG3142	Participates in the control of copper homeostasis
A6E01_RS02585	COG0450	alkyl hydroperoxide reductase
A6E01_RS02590	COG0583	DNA-binding transcription factor activity
A6E01_RS02600	COG3066	DNA modification
A6E01_RS02605	COG0494	nUDIX hydrolase
A6E01_RS02615	COG0730	response to heat
A6E01_RS02620	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A6E01_RS02635	COG1283	sodium-dependent phosphate transmembrane transporter activity
A6E01_RS02640	COG0583	DNA-binding transcription factor activity
A6E01_RS02645	COG0640	Transcriptional regulator
A6E01_RS02650	COG0268	Binds directly to 16S ribosomal RNA
A6E01_RS02655	COG0728	peptidoglycan biosynthetic process
A6E01_RS02660	COG0196	riboflavin kinase activity
A6E01_RS02665	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A6E01_RS02670	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A6E01_RS02675	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A6E01_RS02690	COG0779	Required for maturation of 30S ribosomal subunits
A6E01_RS02695	COG0195	Participates in both transcription termination and antitermination
A6E01_RS02705	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A6E01_RS02710	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A6E01_RS02740	COG1609	Transcriptional regulator
A6E01_RS02745	COG0826	peptidase U32
A6E01_RS02750	COG0826	peptidase U32
A6E01_RS02755	COG3154	lipid carrier protein
A6E01_RS02760	COG3153	acetyltransferase
A6E01_RS02770	COG0456	acetyltransferase
A6E01_RS02775	COG1151	hydroxylamine reductase activity
A6E01_RS02780	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A6E01_RS02780	COG1017	nitric oxide dioxygenase activity
A6E01_RS02785	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
A6E01_RS02790	COG0084	hydrolase, TatD family'
A6E01_RS02795	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A6E01_RS02810	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
A6E01_RS02820	COG0813	purine-nucleoside phosphorylase activity
A6E01_RS02830	COG0560	Phosphoserine phosphatase
A6E01_RS02835	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A6E01_RS02840	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A6E01_RS02845	COG1022	Amp-dependent synthetase and ligase
A6E01_RS02850	COG5433	transposase activity
A6E01_RS02865	COG4974	Belongs to the 'phage' integrase family
A6E01_RS02910	COG4964	Belongs to the GSP D family
A6E01_RS02960	COG3250	beta-galactosidase activity
A6E01_RS02975	COG0534	Mate efflux family protein
A6E01_RS02985	COG2017	converts alpha-aldose to the beta-anomer
A6E01_RS02990	COG1175	transmembrane transport
A6E01_RS02995	COG0395	ABC-type sugar transport system, permease component
A6E01_RS03005	COG1609	Transcriptional regulator
A6E01_RS03010	COG1301	dicarboxylic acid transport
A6E01_RS03015	COG2171	N-acyltransferase activity
A6E01_RS03020	COG3141	response to X-ray
A6E01_RS03025	COG0583	DNA-binding transcription factor activity
A6E01_RS03035	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
A6E01_RS03040	COG1074	ATP-dependent DNA helicase activity
A6E01_RS03045	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A6E01_RS03050	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
A6E01_RS03050	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A6E01_RS03055	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
A6E01_RS03060	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A6E01_RS03065	COG2166	iron-sulfur cluster assembly
A6E01_RS03070	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A6E01_RS03075	COG0693	protein deglycase activity
A6E01_RS03080	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A6E01_RS03085	COG3248	Nucleoside-binding outer membrane protein
A6E01_RS03095	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
A6E01_RS03105	COG1595	DNA-templated transcription, initiation
A6E01_RS03120	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A6E01_RS03135	COG0271	Belongs to the BolA IbaG family
A6E01_RS03140	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
A6E01_RS03145	COG1805	sodium ion transport
A6E01_RS03160	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
A6E01_RS03165	COG2871	sodium ion transport
A6E01_RS03170	COG1477	protein flavinylation
A6E01_RS03175	COG2991	Protein conserved in bacteria
A6E01_RS03185	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A6E01_RS03195	COG1278	Cold shock
A6E01_RS03210	COG0442	prolyl-tRNA aminoacylation
A6E01_RS03215	COG1720	tRNA m6t6A37 methyltransferase activity
A6E01_RS03220	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
A6E01_RS03225	COG1464	Belongs to the NlpA lipoprotein family
A6E01_RS03230	COG2011	ABC-type metal ion transport system permease component
A6E01_RS03235	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A6E01_RS03240	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A6E01_RS03245	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A6E01_RS03255	COG1451	nucleotide metabolic process
A6E01_RS03270	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A6E01_RS03275	COG0321	lipoyl(octanoyl) transferase activity
A6E01_RS03280	COG2921	Belongs to the UPF0250 family
A6E01_RS03285	COG1686	Belongs to the peptidase S11 family
A6E01_RS03290	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A6E01_RS03295	COG0772	Belongs to the SEDS family
A6E01_RS03300	COG0768	penicillin binding
A6E01_RS03305	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A6E01_RS03310	COG0799	negative regulation of ribosome biogenesis
A6E01_RS03315	COG1466	dna polymerase III delta subunit
A6E01_RS03320	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
A6E01_RS03325	COG0495	leucyl-tRNA aminoacylation
A6E01_RS03330	COG2888	peptidyl-tyrosine sulfation
A6E01_RS03340	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A6E01_RS03345	COG4535	Mg2 and Co2 transporter CorC
A6E01_RS03350	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A6E01_RS03355	COG1702	phosphate starvation-inducible protein PhoH
A6E01_RS03365	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A6E01_RS03450	COG0193	aminoacyl-tRNA hydrolase activity
A6E01_RS03455	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A6E01_RS03460	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A6E01_RS03465	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
A6E01_RS03470	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A6E01_RS03475	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A6E01_RS03480	COG2890	protein-(glutamine-N5) methyltransferase activity
A6E01_RS03490	COG2912	Transglutaminase-like superfamily
A6E01_RS03495	COG2877	3-deoxy-8-phosphooctulonate synthase activity
A6E01_RS03500	COG0737	Belongs to the 5'-nucleotidase family
A6E01_RS03520	COG1187	pseudouridine synthase activity
A6E01_RS03525	COG2840	Smr protein MutS2
A6E01_RS03580	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A6E01_RS03585	COG1085	galactose-1-phosphate uridylyltransferase
A6E01_RS03600	COG1609	Transcriptional regulator
A6E01_RS03610	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6E01_RS03625	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
A6E01_RS03655	COG3437	response regulator, receiver
A6E01_RS03665	COG0544	peptidyl-prolyl cis-trans isomerase activity
A6E01_RS03675	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A6E01_RS03680	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A6E01_RS03685	COG0776	regulation of translation
A6E01_RS03690	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6E01_RS03710	COG0232	Belongs to the dGTPase family. Type 2 subfamily
A6E01_RS03715	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
A6E01_RS03720	COG0436	Aminotransferase
A6E01_RS03725	COG1169	isochorismate synthase
A6E01_RS03730	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
A6E01_RS03735	COG2267	carboxylic ester hydrolase activity
A6E01_RS03755	COG2855	membrane
A6E01_RS03770	COG0280	phosphate acetyltransferase
A6E01_RS03770	COG0857	belongs to the CobB CobQ family
A6E01_RS03775	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A6E01_RS03790	COG4120	Belongs to the binding-protein-dependent transport system permease family
A6E01_RS03795	COG1122	ATPase activity
A6E01_RS03800	COG0366	Alpha amylase catalytic
A6E01_RS03805	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A6E01_RS03810	COG0653	protein targeting
A6E01_RS03815	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
A6E01_RS03820	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A6E01_RS03825	COG2186	Transcriptional regulator
A6E01_RS03840	COG0587	DNA-directed DNA polymerase activity
A6E01_RS03870	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
A6E01_RS03875	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A6E01_RS03885	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A6E01_RS03890	COG0583	DNA-binding transcription factor activity
A6E01_RS03895	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A6E01_RS03900	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
A6E01_RS03915	COG0583	DNA-binding transcription factor activity
A6E01_RS03970	COG1953	Uracil, thiamine, allantoin
A6E01_RS03985	COG0583	DNA-binding transcription factor activity
A6E01_RS03990	COG2801	Transposase and inactivated derivatives
A6E01_RS04000	COG1686	Belongs to the peptidase S11 family
A6E01_RS04010	COG5433	transposase activity
A6E01_RS04030	COG3083	sulfuric ester hydrolase activity
A6E01_RS04035	COG3082	Protein of unknown function (DUF1414)
A6E01_RS04040	COG3081	Nucleoid-associated protein
A6E01_RS04045	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A6E01_RS04055	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A6E01_RS04060	COG2095	MarC family integral membrane protein
A6E01_RS04065	COG1454	alcohol dehydrogenase
A6E01_RS04065	COG1012	belongs to the aldehyde dehydrogenase family
A6E01_RS04090	COG1028	Short-chain dehydrogenase reductase Sdr
A6E01_RS04100	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
A6E01_RS04105	COG2056	Na+-H+ antiporter family
A6E01_RS04115	COG0346	lactoylglutathione lyase activity
A6E01_RS04120	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A6E01_RS04125	COG4660	Part of a membrane complex involved in electron transport
A6E01_RS04130	COG4659	FMN binding
A6E01_RS04135	COG4658	electron transport chain
A6E01_RS04140	COG4656	Part of a membrane complex involved in electron transport
A6E01_RS04160	COG0556	nucleotide-excision repair
A6E01_RS04165	COG2204	response regulator
A6E01_RS04170	COG2198	Histidine kinase
A6E01_RS04175	COG0391	Required for morphogenesis under gluconeogenic growth conditions
A6E01_RS04180	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A6E01_RS04185	COG0521	Mo-molybdopterin cofactor biosynthetic process
A6E01_RS04195	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
A6E01_RS04200	COG0314	molybdopterin synthase activity
A6E01_RS04210	COG0601	transmembrane transport
A6E01_RS04215	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6E01_RS04220	COG0444	Belongs to the ABC transporter superfamily
A6E01_RS04230	COG0435	Glutathione S-transferase
A6E01_RS04265	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A6E01_RS04270	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
A6E01_RS04295	COG1522	sequence-specific DNA binding
A6E01_RS04300	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6E01_RS04305	COG1946	Acyl-CoA thioesterase
A6E01_RS04310	COG3126	Type III secretion system lipoprotein chaperone (YscW)
A6E01_RS04355	COG3842	ATPase activity
A6E01_RS04360	COG3459	Glycosyltransferase 36 associated
A6E01_RS04365	COG1609	Transcriptional regulator
A6E01_RS04375	COG1175	transmembrane transport
A6E01_RS04380	COG0395	ABC-type sugar transport system, permease component
A6E01_RS04400	COG1566	PFAM secretion protein HlyD family protein
A6E01_RS04420	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A6E01_RS04425	COG0814	amino acid
A6E01_RS04435	COG0739	heme binding
A6E01_RS04440	COG2814	Major facilitator Superfamily
A6E01_RS04445	COG0861	Integral membrane protein TerC family
A6E01_RS04450	COG1228	amidohydrolase
A6E01_RS04455	COG0659	secondary active sulfate transmembrane transporter activity
A6E01_RS04460	COG0589	response to stress
A6E01_RS04485	COG3344	reverse transcriptase
A6E01_RS04515	COG2273	Hydrolase Family 16
A6E01_RS04530	COG0735	belongs to the Fur family
A6E01_RS04535	COG0625	glutathione transferase activity
A6E01_RS04540	COG5433	transposase activity
A6E01_RS04585	COG0488	(ABC) transporter
A6E01_RS04590	COG3005	denitrification pathway
A6E01_RS04595	COG0243	molybdopterin cofactor binding
A6E01_RS04610	COG0583	DNA-binding transcription factor activity
A6E01_RS04615	COG2814	Major facilitator Superfamily
A6E01_RS04625	COG2860	membrane
A6E01_RS04630	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A6E01_RS04640	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A6E01_RS04660	COG0583	DNA-binding transcription factor activity
A6E01_RS04670	COG1346	cytolysis
A6E01_RS04690	COG5433	transposase activity
A6E01_RS04695	COG0531	amino acid
A6E01_RS04720	COG3842	ATPase activity
A6E01_RS04725	COG0395	ABC-type sugar transport system, permease component
A6E01_RS04730	COG1175	transmembrane transport
A6E01_RS04735	COG1653	transport
A6E01_RS04745	COG1349	DNA-binding transcription factor activity
A6E01_RS04755	COG0534	Mate efflux family protein
A6E01_RS04760	COG0444	Belongs to the ABC transporter superfamily
A6E01_RS04765	COG1124	(ABC) transporter
A6E01_RS04775	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6E01_RS04780	COG1609	Transcriptional regulator
A6E01_RS04785	COG4948	Mandelate Racemase Muconate Lactonizing
A6E01_RS04795	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A6E01_RS04800	COG3383	formate dehydrogenase (NAD+) activity
A6E01_RS04815	COG3046	protein related to deoxyribodipyrimidine photolyase
A6E01_RS04845	COG0583	DNA-binding transcription factor activity
A6E01_RS04850	COG0204	Acyl-transferase
A6E01_RS04855	COG0110	maltose O-acetyltransferase activity
A6E01_RS04860	COG2814	Major facilitator Superfamily
A6E01_RS04865	COG5002	protein histidine kinase activity
A6E01_RS04870	COG0745	RESPONSE REGULATOR receiver
A6E01_RS04895	COG4604	ABC transporter, ATP-binding protein
A6E01_RS04900	COG4605	iron ion homeostasis
A6E01_RS04905	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6E01_RS04910	COG4607	ABC-type enterochelin transport system periplasmic component
A6E01_RS04920	COG4771	TonB-dependent receptor
A6E01_RS04945	COG0617	tRNA 3'-terminal CCA addition
A6E01_RS04945	COG0517	IMP dehydrogenase activity
A6E01_RS04945	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A6E01_RS04950	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
A6E01_RS04960	COG0537	adenosine 5'-monophosphoramidase activity
A6E01_RS04980	COG3150	esterase
A6E01_RS04985	COG1252	NADH dehydrogenase
A6E01_RS04995	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A6E01_RS05000	COG4591	ABC-type transport system involved in lipoprotein release permease component
A6E01_RS05005	COG1136	(ABC) transporter
A6E01_RS05010	COG4591	ABC-type transport system involved in lipoprotein release permease component
A6E01_RS05020	COG2333	competence protein COMEC
A6E01_RS05020	COG0658	competence protein
A6E01_RS05025	COG1132	(ABC) transporter
A6E01_RS05030	COG1663	tetraacyldisaccharide 4'-kinase activity
A6E01_RS05035	COG2835	tetraacyldisaccharide 4'-kinase activity
A6E01_RS05045	COG2719	SpoVR family
A6E01_RS05050	COG2718	Belongs to the UPF0229 family
A6E01_RS05055	COG2766	serine protein kinase
A6E01_RS05065	COG3013	Belongs to the UPF0304 family
A6E01_RS05070	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A6E01_RS05080	COG1882	Formate acetyltransferase
A6E01_RS05105	COG4160	amino acid transport
A6E01_RS05110	COG0708	Exodeoxyribonuclease III
A6E01_RS05125	COG0730	response to heat
A6E01_RS05130	COG1199	ATP-dependent helicase activity
A6E01_RS05140	COG0297	glycogen (starch) synthase activity
A6E01_RS05145	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A6E01_RS05150	COG2915	High frequency lysogenization protein hflD homolog
A6E01_RS05165	COG1187	pseudouridine synthase activity
A6E01_RS05175	COG0531	amino acid
A6E01_RS05200	COG1278	Cold shock
A6E01_RS05205	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
A6E01_RS05210	COG0542	response to heat
A6E01_RS05215	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A6E01_RS05220	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
A6E01_RS05225	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
A6E01_RS05230	COG3134	Outer membrane lipoprotein
A6E01_RS05235	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A6E01_RS05240	COG2992	FlgJ-related protein
A6E01_RS05250	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A6E01_RS05255	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6E01_RS05265	COG1757	Na H antiporter
A6E01_RS05270	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A6E01_RS05275	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A6E01_RS05280	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A6E01_RS05285	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A6E01_RS05285	COG0131	Imidazoleglycerol-phosphate dehydratase
A6E01_RS05290	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A6E01_RS05295	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A6E01_RS05300	COG0107	imidazoleglycerol-phosphate synthase activity
A6E01_RS05305	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A6E01_RS05305	COG0140	phosphoribosyl-ATP diphosphatase activity
A6E01_RS05315	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
A6E01_RS05320	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A6E01_RS05325	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A6E01_RS05330	COG0215	cysteine-tRNA ligase activity
A6E01_RS05335	COG1435	thymidine kinase activity
A6E01_RS05340	COG0189	ligase activity
A6E01_RS05350	COG4067	protein conserved in archaea
A6E01_RS05350	COG0189	ligase activity
A6E01_RS05355	COG0500	methyltransferase
A6E01_RS05360	COG1227	inorganic diphosphatase activity
A6E01_RS05365	COG4172	Belongs to the ABC transporter superfamily
A6E01_RS05380	COG4168	peptide transport system, permease
A6E01_RS05390	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
A6E01_RS05395	COG1842	Phage shock protein A
A6E01_RS05415	COG3104	oligopeptide transport
A6E01_RS05430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6E01_RS05460	COG0519	Catalyzes the synthesis of GMP from XMP
A6E01_RS05470	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A6E01_RS05475	COG3604	Transcriptional regulator
A6E01_RS05485	COG0446	pyridine nucleotide-disulphide oxidoreductase
A6E01_RS05505	COG4628	conserved protein (DUF2132)
A6E01_RS05530	COG2850	peptidyl-arginine hydroxylation
A6E01_RS05540	COG0626	cystathionine gamma-synthase activity
A6E01_RS05550	COG0564	pseudouridine synthase activity
A6E01_RS05555	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A6E01_RS05565	COG2350	Protein conserved in bacteria
A6E01_RS05570	COG1607	acyl-coa hydrolase
A6E01_RS05575	COG2917	probably involved in intracellular septation
A6E01_RS05600	COG1028	Short-chain dehydrogenase reductase Sdr
A6E01_RS05615	COG1301	dicarboxylic acid transport
A6E01_RS05620	COG0159	tryptophan synthase activity
A6E01_RS05625	COG0133	tryptophan synthase activity
A6E01_RS05630	COG0135	phosphoribosylanthranilate isomerase activity
A6E01_RS05630	COG0134	indole-3-glycerol-phosphate synthase activity
A6E01_RS05635	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A6E01_RS05640	COG0512	Glutamine amidotransferase of anthranilate synthase
A6E01_RS05645	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A6E01_RS05650	COG0613	PHP domain protein
A6E01_RS05655	COG0009	L-threonylcarbamoyladenylate synthase
A6E01_RS05660	COG1187	pseudouridine synthase activity
A6E01_RS05665	COG3118	belongs to the thioredoxin family
A6E01_RS05680	COG0431	NADPH-dependent FMN reductase
A6E01_RS05705	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A6E01_RS05725	COG3085	chromosome segregation
A6E01_RS05735	COG1132	(ABC) transporter
A6E01_RS05780	COG0417	DNA replication proofreading
A6E01_RS05785	COG2197	response regulator
A6E01_RS05790	COG0322	excinuclease ABC activity
A6E01_RS05855	COG0019	diaminopimelate decarboxylase activity
A6E01_RS05860	COG0561	phosphatase activity
A6E01_RS05865	COG2207	Transcriptional regulator
A6E01_RS05875	COG3119	arylsulfatase activity
A6E01_RS05885	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A6E01_RS05900	COG2985	domain, Protein
A6E01_RS05930	COG3314	Sporulation integral membrane protein YlbJ
A6E01_RS05935	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A6E01_RS05955	COG0247	lactate metabolic process
A6E01_RS05955	COG0277	FAD linked oxidase domain protein
A6E01_RS05975	COG0678	peroxiredoxin activity
A6E01_RS05995	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A6E01_RS06000	COG1486	melibiose metabolic process
A6E01_RS06005	COG0583	DNA-binding transcription factor activity
A6E01_RS06015	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A6E01_RS06025	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A6E01_RS06030	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A6E01_RS06045	COG2897	thiosulfate sulfurtransferase activity
A6E01_RS06055	COG2133	pyrroloquinoline quinone binding
A6E01_RS06070	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A6E01_RS06075	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6E01_RS06075	COG0072	phenylalanine-tRNA ligase activity
A6E01_RS06080	COG0513	Belongs to the DEAD box helicase family
A6E01_RS06085	COG4895	conserved protein (DUF2196)
A6E01_RS06095	COG0515	serine threonine protein kinase
A6E01_RS06095	COG2815	serine threonine protein kinase
A6E01_RS06115	COG4974	Belongs to the 'phage' integrase family
A6E01_RS06120	COG1247	-acetyltransferase
A6E01_RS06140	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A6E01_RS06150	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A6E01_RS06165	COG1187	pseudouridine synthase activity
A6E01_RS06185	COG0776	regulation of translation
A6E01_RS06190	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
A6E01_RS06195	COG0295	cytidine deaminase activity
A6E01_RS06200	COG1346	cytolysis
A6E01_RS06210	COG2925	Exonuclease
A6E01_RS06220	COG1823	symporter activity
A6E01_RS06240	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A6E01_RS06265	COG0673	inositol 2-dehydrogenase activity
A6E01_RS06280	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A6E01_RS06295	COG1322	Protein conserved in bacteria
A6E01_RS06300	COG0629	single-stranded DNA binding
A6E01_RS06320	COG0420	3'-5' exonuclease activity
A6E01_RS06325	COG0419	ATPase involved in DNA repair
A6E01_RS06365	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A6E01_RS06405	COG2814	Major facilitator Superfamily
A6E01_RS06430	COG1793	dna ligase
A6E01_RS06440	COG0307	riboflavin synthase, alpha
A6E01_RS06450	COG3001	Fructosamine kinase
A6E01_RS06455	COG0791	NLP P60 protein
A6E01_RS06465	COG3148	PFAM DTW domain containing protein
A6E01_RS06470	COG1940	carbohydrate kinase activity
A6E01_RS06495	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A6E01_RS06520	COG0589	response to stress
A6E01_RS06525	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A6E01_RS06535	COG2217	Heavy metal translocating P-type atpase
A6E01_RS06545	COG2010	Cytochrome c
A6E01_RS06560	COG3278	Belongs to the heme-copper respiratory oxidase family
A6E01_RS06570	COG2807	transmembrane transport
A6E01_RS06595	COG1067	ATP-dependent peptidase activity
A6E01_RS06615	COG0488	(ABC) transporter
A6E01_RS06625	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A6E01_RS06625	COG0116	Belongs to the methyltransferase superfamily
A6E01_RS06635	COG0167	dihydroorotate dehydrogenase activity
A6E01_RS06660	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
A6E01_RS06665	COG1956	GAF domain-containing protein
A6E01_RS06670	COG2995	paraquat-inducible protein a
A6E01_RS06675	COG3008	intermembrane lipid transfer
A6E01_RS06690	COG0574	Belongs to the PEP-utilizing enzyme family
A6E01_RS06690	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A6E01_RS06695	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A6E01_RS06700	COG1666	GTP binding
A6E01_RS06710	COG3118	belongs to the thioredoxin family
A6E01_RS06720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6E01_RS06725	COG4597	amino acid ABC transporter
A6E01_RS06730	COG0765	amino acid transport
A6E01_RS06735	COG1126	abc transporter atp-binding protein
A6E01_RS06740	COG0670	Belongs to the BI1 family
A6E01_RS06745	COG2920	part of a sulfur-relay system
A6E01_RS06750	COG1254	Belongs to the acylphosphatase family
A6E01_RS06755	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A6E01_RS06770	COG2885	chlorophyll binding
A6E01_RS06780	COG0561	phosphatase activity
A6E01_RS06800	COG1115	amino acid carrier protein
A6E01_RS06805	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
A6E01_RS06810	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6E01_RS06825	COG1280	lysine exporter protein (LysE YggA)
A6E01_RS06830	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
A6E01_RS06835	COG0281	malic enzyme
A6E01_RS06875	COG3302	dmso reductase anchor subunit
A6E01_RS06880	COG0437	4 iron, 4 sulfur cluster binding
A6E01_RS06885	COG0243	molybdopterin cofactor binding
A6E01_RS06890	COG3381	protein complex oligomerization
A6E01_RS06905	COG1643	Atp-dependent helicase
A6E01_RS06940	COG0443	Heat shock 70 kDa protein
A6E01_RS06945	COG0443	Heat shock 70 kDa protein
A6E01_RS06950	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6E01_RS06950	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6E01_RS06970	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A6E01_RS06980	COG3768	UPF0283 membrane protein
A6E01_RS06985	COG3106	COG3106 Predicted ATPase
A6E01_RS07000	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A6E01_RS07005	COG0494	nUDIX hydrolase
A6E01_RS07010	COG0017	Asparaginyl-tRNA synthetase
A6E01_RS07015	COG1448	Aminotransferase
A6E01_RS07030	COG2176	DNA-directed DNA polymerase activity
A6E01_RS07040	COG3097	Belongs to the UPF0267 family
A6E01_RS07045	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A6E01_RS07060	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
A6E01_RS07070	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6E01_RS07075	COG2989	Protein conserved in bacteria
A6E01_RS07090	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A6E01_RS07095	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A6E01_RS07115	COG1546	Belongs to the CinA family
A6E01_RS07115	COG1058	Belongs to the CinA family
A6E01_RS07125	COG1960	acyl-CoA dehydrogenase activity
A6E01_RS07130	COG1309	transcriptional regulator
A6E01_RS07135	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A6E01_RS07150	COG1136	(ABC) transporter
A6E01_RS07155	COG0702	epimerase
A6E01_RS07165	COG2814	Major facilitator Superfamily
A6E01_RS07170	COG1187	pseudouridine synthase activity
A6E01_RS07175	COG1061	Type III restriction enzyme res subunit
A6E01_RS07180	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A6E01_RS07185	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A6E01_RS07190	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6E01_RS07205	COG4172	Belongs to the ABC transporter superfamily
A6E01_RS07210	COG3313	Fe-S protein
A6E01_RS07230	COG2949	membrane
A6E01_RS07235	COG0492	ferredoxin-NADP+ reductase activity
A6E01_RS07240	COG4988	ABC transporter
A6E01_RS07245	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A6E01_RS07250	COG0604	alcohol dehydrogenase
A6E01_RS07255	COG0583	DNA-binding transcription factor activity
A6E01_RS07260	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A6E01_RS07270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6E01_RS07270	COG4191	Histidine kinase
A6E01_RS07315	COG0415	Belongs to the DNA photolyase family
A6E01_RS07330	COG4166	transmembrane transport
A6E01_RS07345	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A6E01_RS07350	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
A6E01_RS07355	COG3070	regulator of competence-specific genes
A6E01_RS07360	COG2431	L-lysine efflux transmembrane transporter activity
A6E01_RS07370	COG0076	glutamate decarboxylase activity
A6E01_RS07375	COG1737	Transcriptional regulator
A6E01_RS07380	COG1454	alcohol dehydrogenase
A6E01_RS07385	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A6E01_RS07390	COG3104	oligopeptide transport
A6E01_RS07415	COG2079	MmgE PrpD family protein
A6E01_RS07420	COG0372	Belongs to the citrate synthase family
A6E01_RS07425	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
A6E01_RS07435	COG2195	Cleaves the N-terminal amino acid of tripeptides
A6E01_RS07470	COG1757	Na H antiporter
A6E01_RS07475	COG4628	conserved protein (DUF2132)
A6E01_RS07480	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6E01_RS07500	COG5413	integral membrane protein
A6E01_RS07510	COG5413	integral membrane protein
A6E01_RS07520	COG1272	protein, Hemolysin III
A6E01_RS07535	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
A6E01_RS07555	COG0747	negative chemotaxis
A6E01_RS07565	COG1263	PTS System
A6E01_RS07565	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6E01_RS07570	COG0471	metal ion transport
A6E01_RS07590	COG2217	Heavy metal translocating P-type atpase
A6E01_RS07595	COG0789	Transcriptional regulator
A6E01_RS07615	COG4232	protein-disulfide reductase activity
A6E01_RS07620	COG3118	belongs to the thioredoxin family
A6E01_RS07625	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A6E01_RS07625	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A6E01_RS07645	COG0826	peptidase U32
A6E01_RS07660	COG0702	epimerase
A6E01_RS07680	COG2358	TRAP transporter, solute receptor (TAXI family
A6E01_RS07685	COG2153	protein acetylation
A6E01_RS07695	COG0513	Belongs to the DEAD box helicase family
A6E01_RS07710	COG0437	4 iron, 4 sulfur cluster binding
A6E01_RS07715	COG3383	formate dehydrogenase (NAD+) activity
A6E01_RS07745	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A6E01_RS07755	COG4662	Binding-protein-dependent transport system inner membrane component
A6E01_RS07765	COG0746	molybdenum cofactor guanylyltransferase activity
A6E01_RS07770	COG0303	'Molybdopterin
A6E01_RS07780	COG0346	lactoylglutathione lyase activity
A6E01_RS07785	COG1902	pentaerythritol trinitrate reductase activity
A6E01_RS07795	COG1024	Enoyl-CoA hydratase
A6E01_RS07805	COG0493	'glutamate synthase
A6E01_RS07810	COG0674	pyruvate-flavodoxin oxidoreductase activity
A6E01_RS07825	COG0564	pseudouridine synthase activity
A6E01_RS07830	COG0514	ATP-dependent DNA helicase (RecQ)
A6E01_RS07835	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6E01_RS07845	COG0318	PFAM AMP-dependent synthetase and ligase
A6E01_RS07850	COG0786	glutamate:sodium symporter activity
A6E01_RS07880	COG1196	nuclear chromosome segregation
A6E01_RS07890	COG1401	restriction endodeoxyribonuclease activity
A6E01_RS07895	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
A6E01_RS07920	COG1360	Flagellar Motor Protein
A6E01_RS07950	COG5433	transposase activity
A6E01_RS08000	COG0582	viral genome integration into host DNA
A6E01_RS08015	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A6E01_RS08020	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
A6E01_RS08025	COG2885	chlorophyll binding
A6E01_RS08030	COG0823	Involved in the tonB-independent uptake of proteins
A6E01_RS08045	COG0811	peptide transport
A6E01_RS08050	COG0824	Thioesterase
A6E01_RS08060	COG4890	Cyd operon protein YbgT
A6E01_RS08065	COG1294	oxidase, subunit
A6E01_RS08070	COG1271	oxidase subunit
A6E01_RS08080	COG0632	four-way junction helicase activity
A6E01_RS08095	COG4106	trans-aconitate 2-methyltransferase activity
A6E01_RS08105	COG0243	molybdopterin cofactor binding
A6E01_RS08110	COG3005	denitrification pathway
A6E01_RS08115	COG4459	periplasmic nitrate reductase
A6E01_RS08130	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
A6E01_RS08135	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
A6E01_RS08140	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
A6E01_RS08145	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A6E01_RS08150	COG1434	Gram-negative-bacterium-type cell wall biogenesis
A6E01_RS08160	COG1609	Transcriptional regulator
A6E01_RS08185	COG2268	Band 7 protein
A6E01_RS08195	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A6E01_RS08210	COG0300	oxidoreductase activity
A6E01_RS08220	COG0501	Belongs to the peptidase M48B family
A6E01_RS08225	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A6E01_RS08230	COG1073	alpha beta
A6E01_RS08230	COG2226	methyltransferase
A6E01_RS08235	COG0156	8-amino-7-oxononanoate synthase activity
A6E01_RS08240	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A6E01_RS08245	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A6E01_RS08255	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A6E01_RS08260	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
A6E01_RS08270	COG1522	sequence-specific DNA binding
A6E01_RS08275	COG0686	Belongs to the AlaDH PNT family
A6E01_RS08285	COG0583	DNA-binding transcription factor activity
A6E01_RS08300	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
A6E01_RS08305	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
A6E01_RS08310	COG0776	regulation of translation
A6E01_RS08315	COG0539	negative regulation of cytoplasmic translation
A6E01_RS08330	COG0616	signal peptide processing
A6E01_RS08335	COG1028	Short-chain dehydrogenase reductase Sdr
A6E01_RS08345	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A6E01_RS08350	COG0778	Nitroreductase
A6E01_RS08355	COG1902	pentaerythritol trinitrate reductase activity
A6E01_RS08355	COG0446	pyridine nucleotide-disulphide oxidoreductase
A6E01_RS08360	COG0616	signal peptide processing
A6E01_RS08365	COG0252	asparaginase activity
A6E01_RS08375	COG3139	Protein of unknown function (DUF1315)
A6E01_RS08380	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6E01_RS08390	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A6E01_RS08395	COG0676	glucose-6-phosphate 1-epimerase activity
A6E01_RS08400	COG2226	methyltransferase
A6E01_RS08410	COG2983	Belongs to the UPF0260 family
A6E01_RS08420	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A6E01_RS08425	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A6E01_RS08440	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A6E01_RS08445	COG2832	Protein of unknown function (DUF454)
A6E01_RS08450	COG0745	RESPONSE REGULATOR receiver
A6E01_RS08455	COG0583	DNA-binding transcription factor activity
A6E01_RS08460	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A6E01_RS08465	COG1286	toxin biosynthetic process
A6E01_RS08470	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
A6E01_RS08475	COG0285	dihydrofolate synthase activity
A6E01_RS08480	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A6E01_RS08485	COG0101	tRNA pseudouridine synthase activity
A6E01_RS08495	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A6E01_RS08500	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A6E01_RS08505	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A6E01_RS08525	COG3101	peptidyl-lysine hydroxylation
A6E01_RS08530	COG2860	membrane
A6E01_RS08540	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A6E01_RS08545	COG2890	protein-(glutamine-N5) methyltransferase activity
A6E01_RS08550	COG2840	Smr protein MutS2
A6E01_RS08555	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
A6E01_RS08560	COG2062	phosphohistidine phosphatase, SixA
A6E01_RS08565	COG1025	Belongs to the peptidase M16 family
A6E01_RS08575	COG1250	3-hydroxyacyl-CoA dehydrogenase
A6E01_RS08575	COG1024	Enoyl-CoA hydratase
A6E01_RS08580	COG0183	Belongs to the thiolase family
A6E01_RS08585	COG1595	DNA-templated transcription, initiation
A6E01_RS08595	COG2067	long-chain fatty acid transport protein
A6E01_RS08605	COG2853	Lipoprotein
A6E01_RS08610	COG4235	cytochrome complex assembly
A6E01_RS08610	COG3088	subunit of a heme lyase
A6E01_RS08620	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6E01_RS08625	COG1138	Cytochrome C-type biogenesis protein
A6E01_RS08640	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A6E01_RS08645	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A6E01_RS08650	COG4133	protoheme IX ABC transporter activity
A6E01_RS08665	COG0583	DNA-binding transcription factor activity
A6E01_RS08670	COG0737	Belongs to the 5'-nucleotidase family
A6E01_RS08680	COG1929	Belongs to the glycerate kinase type-1 family
A6E01_RS08685	COG0383	alpha-mannosidase activity
A6E01_RS08690	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6E01_RS08690	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6E01_RS08690	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6E01_RS08695	COG2188	Transcriptional regulator
A6E01_RS08705	COG1595	DNA-templated transcription, initiation
A6E01_RS08715	COG2095	MarC family integral membrane protein
A6E01_RS08720	COG1902	pentaerythritol trinitrate reductase activity
A6E01_RS08730	COG3069	C4-dicarboxylate transmembrane transporter activity
A6E01_RS08735	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A6E01_RS08745	COG1794	racemase activity, acting on amino acids and derivatives
A6E01_RS08750	COG2982	Protein involved in outer membrane biogenesis
A6E01_RS08755	COG0572	uridine kinase
A6E01_RS08760	COG0489	protein tyrosine kinase activity
A6E01_RS08765	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6E01_RS08765	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6E01_RS08775	COG1940	carbohydrate kinase activity
A6E01_RS08780	COG4667	esterase of the alpha-beta hydrolase superfamily
A6E01_RS08790	COG0733	neurotransmitter:sodium symporter activity
A6E01_RS08800	COG1263	PTS System
A6E01_RS08800	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6E01_RS08805	COG0084	hydrolase, TatD family'
A6E01_RS08810	COG0470	DNA polymerase III
A6E01_RS08815	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A6E01_RS08820	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A6E01_RS08850	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A6E01_RS08855	COG0416	fatty acid biosynthetic process
A6E01_RS08860	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A6E01_RS08865	COG1399	metal-binding, possibly nucleic acid-binding protein
A6E01_RS08870	COG0424	maF-like protein
A6E01_RS08875	COG0564	pseudouridine synthase activity
A6E01_RS08880	COG1530	ribonuclease E activity
A6E01_RS08885	COG0659	secondary active sulfate transmembrane transporter activity
A6E01_RS08920	COG0667	Aldo Keto reductase
A6E01_RS08935	COG3135	benzoate transporter
A6E01_RS08940	COG1396	sequence-specific DNA binding
A6E01_RS08945	COG0697	spore germination
A6E01_RS08965	COG0679	Auxin Efflux Carrier
A6E01_RS08975	COG1461	Dihydroxyacetone kinase
A6E01_RS08980	COG2376	Dihydroxyacetone kinase
A6E01_RS08990	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A6E01_RS08990	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
A6E01_RS09000	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A6E01_RS09005	COG0698	ribose 5-phosphate isomerase
A6E01_RS09010	COG1494	fructose-1,6-bisphosphatase
A6E01_RS09025	COG1472	Belongs to the glycosyl hydrolase 3 family
A6E01_RS09050	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A6E01_RS09055	COG2951	lytic endotransglycosylase activity
A6E01_RS09060	COG3100	YcgL domain-containing protein
A6E01_RS09065	COG0850	regulation of cytokinetic process
A6E01_RS09070	COG2894	cell division
A6E01_RS09075	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
A6E01_RS09080	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
A6E01_RS09085	COG0318	PFAM AMP-dependent synthetase and ligase
A6E01_RS09100	COG1214	PFAM Peptidase M22, glycoprotease
A6E01_RS09105	COG1199	ATP-dependent helicase activity
A6E01_RS09110	COG0788	formyltetrahydrofolate deformylase activity
A6E01_RS09115	COG3102	Protein conserved in bacteria
A6E01_RS09125	COG1227	inorganic diphosphatase activity
A6E01_RS09140	COG0534	Mate efflux family protein
A6E01_RS09145	COG0583	DNA-binding transcription factor activity
A6E01_RS09150	COG0733	neurotransmitter:sodium symporter activity
A6E01_RS09175	COG1918	ferrous iron import across plasma membrane
A6E01_RS09180	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
A6E01_RS09185	COG1121	(ABC) transporter
A6E01_RS09190	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A6E01_RS09205	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6E01_RS09210	COG0567	Dehydrogenase, E1 component
A6E01_RS09220	COG1053	succinate dehydrogenase
A6E01_RS09225	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
A6E01_RS09235	COG0372	Belongs to the citrate synthase family
A6E01_RS09240	COG4580	involved in the transport of maltose and maltodextrins
A6E01_RS09270	COG1609	Transcriptional regulator
A6E01_RS09275	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A6E01_RS09285	COG0033	Phosphoglucomutase
A6E01_RS09290	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
A6E01_RS09295	COG0596	Alpha beta hydrolase
A6E01_RS09310	COG0735	belongs to the Fur family
A6E01_RS09320	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6E01_RS09325	COG1263	PTS System
A6E01_RS09325	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6E01_RS09325	COG2190	(PTS) system
A6E01_RS09330	COG0363	glucosamine-6-phosphate deaminase activity
A6E01_RS09335	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A6E01_RS09340	COG1940	carbohydrate kinase activity
A6E01_RS09340	COG1846	Transcriptional regulator
A6E01_RS09345	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A6E01_RS09345	COG4651	solute:proton antiporter activity
A6E01_RS09350	COG3706	GGDEF domain
A6E01_RS09350	COG2203	Gaf domain
A6E01_RS09350	COG4251	negative regulation of phosphorylation
A6E01_RS09350	COG5001	Diguanylate cyclase
A6E01_RS09355	COG0367	asparagine synthase
A6E01_RS09365	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A6E01_RS09375	COG0326	Molecular chaperone. Has ATPase activity
A6E01_RS09380	COG3710	Transcriptional regulator
A6E01_RS09390	COG0622	Phosphoesterase
A6E01_RS09415	COG1090	epimerase
A6E01_RS09420	COG3118	belongs to the thioredoxin family
A6E01_RS09425	COG0330	HflC and HflK could
A6E01_RS09440	COG3115	cell septum assembly
A6E01_RS09445	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
A6E01_RS09455	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6E01_RS09465	COG2190	(PTS) system
A6E01_RS09470	COG2837	iron assimilation
A6E01_RS09490	COG1393	Belongs to the ArsC family
A6E01_RS09495	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A6E01_RS09510	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
A6E01_RS09515	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A6E01_RS09520	COG2716	regulation of RNA biosynthetic process
A6E01_RS09525	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A6E01_RS09535	COG4783	chaperone-mediated protein folding
A6E01_RS09540	COG1393	Belongs to the ArsC family
A6E01_RS09550	COG3507	Belongs to the glycosyl hydrolase 43 family
A6E01_RS09560	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A6E01_RS09565	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A6E01_RS09570	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A6E01_RS09580	COG3335	DDE superfamily endonuclease
A6E01_RS09585	COG0121	glutamine amidotransferase
A6E01_RS09590	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A6E01_RS09595	COG1960	acyl-CoA dehydrogenase activity
A6E01_RS09605	COG0328	RNA-DNA hybrid ribonuclease activity
A6E01_RS09610	COG2226	methyltransferase
A6E01_RS09615	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6E01_RS09620	COG1388	LysM domain
A6E01_RS09620	COG0741	lytic transglycosylase activity
A6E01_RS09625	COG3021	interspecies interaction between organisms
A6E01_RS09630	COG0347	Belongs to the P(II) protein family
A6E01_RS09645	COG0825	malonyl-CoA metabolic process
A6E01_RS09650	COG0587	DNA-directed DNA polymerase activity
A6E01_RS09655	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A6E01_RS09670	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A6E01_RS09675	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A6E01_RS09680	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
A6E01_RS09685	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A6E01_RS09690	COG0750	zinc metalloprotease
A6E01_RS09700	COG0575	Belongs to the CDS family
A6E01_RS09705	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A6E01_RS09730	COG0024	Methionine aminopeptidase
A6E01_RS09735	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
A6E01_RS09740	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
A6E01_RS09750	COG0564	pseudouridine synthase activity
A6E01_RS09755	COG3098	single-species biofilm formation
A6E01_RS09780	COG1671	Belongs to the UPF0178 family
A6E01_RS09785	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
A6E01_RS09795	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A6E01_RS09800	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
A6E01_RS09810	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A6E01_RS09810	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A6E01_RS09820	COG1611	Belongs to the LOG family
A6E01_RS09825	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6E01_RS09835	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
A6E01_RS09840	COG0583	DNA-binding transcription factor activity
A6E01_RS09845	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6E01_RS09845	COG0301	tRNA thio-modification
A6E01_RS09850	COG1722	exodeoxyribonuclease VII activity
A6E01_RS09855	COG0142	geranyltranstransferase activity
A6E01_RS09860	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A6E01_RS09865	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A6E01_RS09870	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A6E01_RS09875	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A6E01_RS09895	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A6E01_RS09895	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A6E01_RS09905	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A6E01_RS09910	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A6E01_RS09920	COG1073	alpha beta
A6E01_RS09925	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
A6E01_RS09930	COG2252	PERMEase
A6E01_RS09935	COG2195	Cleaves the N-terminal amino acid of tripeptides
A6E01_RS09945	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A6E01_RS09945	COG0047	phosphoribosylformylglycinamidine synthase activity
A6E01_RS09950	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
A6E01_RS09975	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
A6E01_RS10000	COG0484	heat shock protein binding
A6E01_RS10005	COG0443	Heat shock 70 kDa protein
A6E01_RS10010	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A6E01_RS10015	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A6E01_RS10020	COG0497	DNA recombination
A6E01_RS10025	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A6E01_RS10030	COG2914	Belongs to the UPF0125 (RnfH) family
A6E01_RS10035	COG2867	negative regulation of translational initiation
A6E01_RS10040	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A6E01_RS10060	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A6E01_RS10075	COG1028	Short-chain dehydrogenase reductase Sdr
A6E01_RS10080	COG1917	Cupin 2, conserved barrel domain protein
A6E01_RS10085	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6E01_RS10090	COG1904	glucuronate isomerase
A6E01_RS10105	COG0765	amino acid transport
A6E01_RS10115	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
A6E01_RS10120	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A6E01_RS10125	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A6E01_RS10135	COG4221	oxidoreductase activity
A6E01_RS10140	COG0583	DNA-binding transcription factor activity
A6E01_RS10145	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6E01_RS10150	COG0110	maltose O-acetyltransferase activity
A6E01_RS10175	COG3181	Tripartite tricarboxylate transporter family receptor
A6E01_RS10185	COG0798	PFAM Bile acid sodium symporter
A6E01_RS10195	COG0583	DNA-binding transcription factor activity
A6E01_RS10200	COG2116	formate transmembrane transporter activity
A6E01_RS10205	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A6E01_RS10210	COG4136	ATPase activity
A6E01_RS10215	COG4135	transport system, permease component
A6E01_RS10220	COG4134	Bacterial extracellular solute-binding protein
A6E01_RS10225	COG3122	Protein conserved in bacteria
A6E01_RS10235	COG0516	GMP reductase activity
A6E01_RS10235	COG0517	IMP dehydrogenase activity
A6E01_RS10250	COG1160	GTP binding
A6E01_RS10255	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A6E01_RS10260	COG2976	Protein conserved in bacteria
A6E01_RS10265	COG0124	histidyl-tRNA synthetase
A6E01_RS10270	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A6E01_RS10295	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A6E01_RS10300	COG2975	iron-sulfur cluster assembly
A6E01_RS10305	COG0633	Ferredoxin
A6E01_RS10310	COG0443	Heat shock 70 kDa protein
A6E01_RS10320	COG0316	Belongs to the HesB IscA family
A6E01_RS10325	COG0822	iron-sulfur transferase activity
A6E01_RS10345	COG0483	inositol monophosphate 1-phosphatase activity
A6E01_RS10350	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A6E01_RS10355	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A6E01_RS10360	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A6E01_RS10365	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
A6E01_RS10370	COG1534	Rna-binding protein
A6E01_RS10375	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A6E01_RS10380	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
A6E01_RS10385	COG2027	D-alanyl-D-alanine carboxypeptidase
A6E01_RS10390	COG2239	Acts as a magnesium transporter
A6E01_RS10395	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A6E01_RS10400	COG0739	heme binding
A6E01_RS10410	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A6E01_RS10415	COG1566	PFAM secretion protein HlyD family protein
A6E01_RS10430	COG0628	permease
A6E01_RS10435	COG2813	Specifically methylates the guanine in position
A6E01_RS10440	COG0784	Response regulator, receiver
A6E01_RS10440	COG2205	protein histidine kinase activity
A6E01_RS10445	COG0747	negative chemotaxis
A6E01_RS10460	COG0444	Belongs to the ABC transporter superfamily
A6E01_RS10465	COG4608	Belongs to the ABC transporter superfamily
A6E01_RS10480	COG3842	ATPase activity
A6E01_RS10490	COG1840	ABC-type Fe3 transport system, periplasmic component
A6E01_RS10495	COG0004	ammonium transporteR
A6E01_RS10510	COG3835	regulator
A6E01_RS10515	COG2610	gluconate transmembrane transporter activity
A6E01_RS10520	COG1929	Belongs to the glycerate kinase type-1 family
A6E01_RS10525	COG1049	propionate catabolic process, 2-methylcitrate cycle
A6E01_RS10530	COG1752	Esterase of the alpha-beta hydrolase superfamily
A6E01_RS10535	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A6E01_RS10540	COG1643	Atp-dependent helicase
A6E01_RS10550	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A6E01_RS10555	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6E01_RS10565	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A6E01_RS10570	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A6E01_RS10575	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A6E01_RS10580	COG0842	Transport permease protein
A6E01_RS10585	COG1131	(ABC) transporter
A6E01_RS10590	COG0288	reversible hydration of carbon dioxide
A6E01_RS10600	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6E01_RS10605	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6E01_RS10610	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
A6E01_RS10615	COG2186	Transcriptional regulator
A6E01_RS10625	COG0157	Belongs to the NadC ModD family
A6E01_RS10635	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A6E01_RS10640	COG1459	type II secretion system
A6E01_RS10650	COG0237	dephospho-CoA kinase activity
A6E01_RS10655	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
A6E01_RS10660	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
A6E01_RS10665	COG0335	large ribosomal subunit rRNA binding
A6E01_RS10670	COG0336	Belongs to the RNA methyltransferase TrmD family
A6E01_RS10685	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A6E01_RS10690	COG4137	Cytochrome C assembly protein
A6E01_RS10695	COG4536	flavin adenine dinucleotide binding
A6E01_RS10700	COG1854	S-ribosylhomocysteine lyase activity
A6E01_RS10710	COG0612	Peptidase, M16
A6E01_RS10715	COG1238	metal cluster binding
A6E01_RS10720	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
A6E01_RS10725	COG5016	pyruvate
A6E01_RS10725	COG0511	ligase activity, forming carbon-carbon bonds
A6E01_RS10730	COG3630	sodium ion export across plasma membrane
A6E01_RS10780	COG0527	aspartate kinase activity
A6E01_RS10790	COG2137	regulation of response to DNA damage stimulus
A6E01_RS10795	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A6E01_RS10805	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A6E01_RS10810	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A6E01_RS10815	COG4942	peptidase
A6E01_RS10815	COG1388	LysM domain
A6E01_RS10820	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A6E01_RS10825	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
A6E01_RS10830	COG0585	pseudouridine synthase activity
A6E01_RS10835	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A6E01_RS10850	COG0148	phosphopyruvate hydratase activity
A6E01_RS10860	COG3956	TIGRFAM MazG family protein
A6E01_RS10865	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A6E01_RS10880	COG0736	holo-[acyl-carrier-protein] synthase activity
A6E01_RS10885	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
A6E01_RS10890	COG1381	Involved in DNA repair and RecF pathway recombination
A6E01_RS10895	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A6E01_RS10900	COG0571	ribonuclease III activity
A6E01_RS10910	COG0481	GTPase activity
A6E01_RS10920	COG3026	antisigma factor binding
A6E01_RS10935	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A6E01_RS10940	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
A6E01_RS10945	COG0354	folic acid binding
A6E01_RS10960	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A6E01_RS10965	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A6E01_RS10970	COG3079	Belongs to the UPF0149 family
A6E01_RS10985	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A6E01_RS10990	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A6E01_RS10995	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A6E01_RS11005	COG0668	transmembrane transport
A6E01_RS11010	COG0191	fructose-bisphosphate aldolase activity
A6E01_RS11020	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A6E01_RS11025	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A6E01_RS11030	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A6E01_RS11040	COG3091	SprT-like family
A6E01_RS11045	COG2356	endonuclease I
A6E01_RS11050	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A6E01_RS11055	COG0189	ligase activity
A6E01_RS11060	COG1678	Uncharacterized ACR, COG1678
A6E01_RS11065	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A6E01_RS11080	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A6E01_RS11085	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A6E01_RS11090	COG0762	integral membrane protein
A6E01_RS11100	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A6E01_RS11105	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A6E01_RS11110	COG2066	Belongs to the glutaminase family
A6E01_RS11125	COG1194	a g-specific adenine glycosylase
A6E01_RS11130	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
A6E01_RS11200	COG2213	PTS system mannitol-specific
A6E01_RS11200	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6E01_RS11205	COG0246	Mannitol dehydrogenase
A6E01_RS11210	COG3722	fumarate hydratase activity
A6E01_RS11215	COG0363	glucosamine-6-phosphate deaminase activity
A6E01_RS11220	COG1349	DNA-binding transcription factor activity
A6E01_RS11225	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A6E01_RS11230	COG1609	Transcriptional regulator
A6E01_RS11230	COG2207	Transcriptional regulator
A6E01_RS11235	COG2115	Belongs to the xylose isomerase family
A6E01_RS11250	COG2382	esterase
A6E01_RS11250	COG3693	PFAM glycoside hydrolase, family 10
A6E01_RS11250	COG3507	Belongs to the glycosyl hydrolase 43 family
A6E01_RS11255	COG0395	ABC-type sugar transport system, permease component
A6E01_RS11260	COG1175	transmembrane transport
A6E01_RS11270	COG3842	ATPase activity
A6E01_RS11275	COG3842	ATPase activity
A6E01_RS11280	COG2115	Belongs to the xylose isomerase family
A6E01_RS11285	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A6E01_RS11290	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A6E01_RS11295	COG1070	Carbohydrate kinase
A6E01_RS11310	COG0795	lipopolysaccharide-transporting ATPase activity
A6E01_RS11315	COG0795	lipopolysaccharide-transporting ATPase activity
A6E01_RS11325	COG2927	DNA polymerase III (CHI subunit)
A6E01_RS11330	COG0525	valine-tRNA ligase activity
A6E01_RS11365	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
A6E01_RS11370	COG0251	oxidation-reduction process
A6E01_RS11375	COG0204	Acyl-transferase
A6E01_RS11385	COG5007	Belongs to the BolA IbaG family
A6E01_RS11395	COG2854	intermembrane phospholipid transfer
A6E01_RS11400	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A6E01_RS11405	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A6E01_RS11410	COG1127	ABC transporter
A6E01_RS11420	COG0517	IMP dehydrogenase activity
A6E01_RS11420	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A6E01_RS11425	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
A6E01_RS11440	COG1137	ATPase activity
A6E01_RS11455	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6E01_RS11460	COG1660	Displays ATPase and GTPase activities
A6E01_RS11465	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6E01_RS11470	COG2239	Acts as a magnesium transporter
A6E01_RS11475	COG0312	modulator of DNA gyrase
A6E01_RS11480	COG3028	Belongs to the UPF0307 family
A6E01_RS11485	COG0312	modulator of DNA gyrase
A6E01_RS11490	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A6E01_RS11495	COG3164	Protein of unknown function
A6E01_RS11505	COG0424	maF-like protein
A6E01_RS11510	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
A6E01_RS11515	COG1792	Involved in formation and maintenance of cell shape
A6E01_RS11520	COG1077	Cell shape determining protein MreB Mrl
A6E01_RS11550	COG2165	general secretion pathway protein
A6E01_RS11555	COG4969	Belongs to the N-Me-Phe pilin family
A6E01_RS11560	COG2165	general secretion pathway protein
A6E01_RS11570	COG1459	type II secretion system
A6E01_RS11575	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A6E01_RS11585	COG3409	Peptidoglycan-binding domain 1 protein
A6E01_RS11585	COG3267	Type II secretory pathway component ExeA
A6E01_RS11590	COG1450	Type ii and iii secretion system protein
A6E01_RS11610	COG2200	EAL domain
A6E01_RS11610	COG2199	diguanylate cyclase activity
A6E01_RS11630	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A6E01_RS11640	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A6E01_RS11645	COG0527	aspartate kinase activity
A6E01_RS11650	COG1410	methionine synthase
A6E01_RS11650	COG0646	methionine synthase
A6E01_RS11675	COG3335	DDE superfamily endonuclease
A6E01_RS11755	COG0175	sulfate reduction
A6E01_RS11760	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A6E01_RS11765	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A6E01_RS11785	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A6E01_RS11795	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A6E01_RS11820	COG2965	DNA replication, synthesis of RNA primer
A6E01_RS11830	COG0778	Nitroreductase
A6E01_RS11835	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A6E01_RS11840	COG0557	exoribonuclease II activity
A6E01_RS11845	COG1959	2 iron, 2 sulfur cluster binding
A6E01_RS11850	COG1017	nitric oxide dioxygenase activity
A6E01_RS11850	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A6E01_RS11855	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A6E01_RS11860	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
A6E01_RS11865	COG0330	HflC and HflK could
A6E01_RS11870	COG0330	HflC and HflK could
A6E01_RS11875	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A6E01_RS11880	COG1923	regulation of RNA biosynthetic process
A6E01_RS11885	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A6E01_RS11890	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A6E01_RS11895	COG0860	N-Acetylmuramoyl-L-alanine amidase
A6E01_RS11900	COG0802	atpase or kinase
A6E01_RS11905	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A6E01_RS11960	COG1162	GTPase activity
A6E01_RS11965	COG0688	phosphatidylethanolamine metabolic process
A6E01_RS11975	COG1575	Belongs to the MenA family. Type 1 subfamily
A6E01_RS11980	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A6E01_RS11985	COG0471	metal ion transport
A6E01_RS11985	COG3273	potassium ion transport
A6E01_RS12000	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
A6E01_RS12005	COG1053	succinate dehydrogenase
A6E01_RS12010	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A6E01_RS12015	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
A6E01_RS12025	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A6E01_RS12030	COG1509	lysine 2,3-aminomutase activity
A6E01_RS12040	COG0488	(ABC) transporter
A6E01_RS12045	COG1119	ATPase activity
A6E01_RS12065	COG0534	Mate efflux family protein
A6E01_RS12075	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A6E01_RS12080	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
A6E01_RS12085	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6E01_RS12090	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
A6E01_RS12095	COG4942	peptidase
A6E01_RS12105	COG1494	fructose-1,6-bisphosphatase
A6E01_RS12125	COG0205	6-phosphofructokinase activity
A6E01_RS12140	COG0745	RESPONSE REGULATOR receiver
A6E01_RS12145	COG2205	protein histidine kinase activity
A6E01_RS12150	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A6E01_RS12155	COG3030	protein affecting phage T7 exclusion by the F plasmid
A6E01_RS12165	COG1027	Aspartate ammonia-lyase
A6E01_RS12170	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A6E01_RS12175	COG4232	protein-disulfide reductase activity
A6E01_RS12190	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6E01_RS12200	COG0784	Response regulator, receiver
A6E01_RS12200	COG2198	Histidine kinase
A6E01_RS12200	COG2205	protein histidine kinase activity
A6E01_RS12205	COG2814	Major facilitator Superfamily
A6E01_RS12220	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A6E01_RS12225	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A6E01_RS12230	COG0511	ligase activity, forming carbon-carbon bonds
A6E01_RS12235	COG0439	Biotin carboxylase
A6E01_RS12250	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
A6E01_RS12265	COG0789	Transcriptional regulator
A6E01_RS12275	COG0151	Belongs to the GarS family
A6E01_RS12285	COG2207	Transcriptional regulator
A6E01_RS12300	COG1253	flavin adenine dinucleotide binding
A6E01_RS12305	COG3068	Protein conserved in bacteria
A6E01_RS12320	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
A6E01_RS12325	COG1561	YicC-like family, N-terminal region
A6E01_RS12340	COG0194	GDP metabolic process
A6E01_RS12345	COG1758	RNA polymerase activity
A6E01_RS12350	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A6E01_RS12355	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A6E01_RS12360	COG2003	Belongs to the UPF0758 family
A6E01_RS12365	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A6E01_RS12370	COG0756	dUTP diphosphatase activity
A6E01_RS12375	COG1309	transcriptional regulator
A6E01_RS12380	COG1560	Kdo2-lipid A biosynthetic process
A6E01_RS12385	COG1560	Kdo2-lipid A biosynthetic process
A6E01_RS12395	COG2816	NAD+ diphosphatase activity
A6E01_RS12400	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
A6E01_RS12405	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A6E01_RS12410	COG0085	RNA polymerase activity
A6E01_RS12425	COG0081	regulation of translation
A6E01_RS12435	COG0250	Participates in transcription elongation, termination and antitermination
A6E01_RS12440	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A6E01_RS12445	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A6E01_RS12470	COG1072	(Pantothenic acid kinase))
A6E01_RS12475	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
A6E01_RS12475	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
A6E01_RS12480	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A6E01_RS12490	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A6E01_RS12500	COG3335	DDE superfamily endonuclease
A6E01_RS12560	COG0724	RNA recognition motif
A6E01_RS12565	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A6E01_RS12570	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A6E01_RS12585	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6E01_RS12590	COG0534	Mate efflux family protein
A6E01_RS12600	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A6E01_RS12605	COG2937	Belongs to the GPAT DAPAT family
A6E01_RS12610	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A6E01_RS12615	COG3161	chorismate lyase activity
A6E01_RS12620	COG0705	Rhomboid family
A6E01_RS12625	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6E01_RS12635	COG2177	Part of the ABC transporter FtsEX involved in
A6E01_RS12640	COG2884	Cell division ATP-binding protein ftsE
A6E01_RS12645	COG0552	protein localization to endoplasmic reticulum
A6E01_RS12650	COG0742	ribosomal rna small subunit methyltransferase
A6E01_RS12690	COG0210	DNA helicase
A6E01_RS12695	COG1309	transcriptional regulator
A6E01_RS12700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6E01_RS12705	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A6E01_RS12715	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A6E01_RS12720	COG0583	DNA-binding transcription factor activity
A6E01_RS12745	COG3335	DDE superfamily endonuclease
A6E01_RS12785	COG2871	sodium ion transport
A6E01_RS12790	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
A6E01_RS12805	COG3118	belongs to the thioredoxin family
A6E01_RS12810	COG0513	Belongs to the DEAD box helicase family
A6E01_RS12815	COG0248	Ppx GppA phosphatase
A6E01_RS12820	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A6E01_RS12825	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
A6E01_RS12835	COG0514	ATP-dependent DNA helicase (RecQ)
A6E01_RS12840	COG2962	Rard protein
A6E01_RS12845	COG1280	lysine exporter protein (LysE YggA)
A6E01_RS12850	COG0405	Gamma-glutamyltransferase
A6E01_RS12855	COG2095	MarC family integral membrane protein
A6E01_RS12860	COG0210	DNA helicase
A6E01_RS12870	COG3220	belongs to the UPF0276 family
A6E01_RS12900	COG2022	thiamine diphosphate biosynthetic process
A6E01_RS12910	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A6E01_RS12915	COG0352	thiamine-phosphate diphosphorylase activity
A6E01_RS12965	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A6E01_RS12970	COG1739	Uncharacterized protein family UPF0029
A6E01_RS12980	COG0183	Belongs to the thiolase family
A6E01_RS12985	COG0604	alcohol dehydrogenase
A6E01_RS12990	COG0583	DNA-binding transcription factor activity
A6E01_RS13000	COG2119	membrane
A6E01_RS13005	COG0752	glycyl-tRNA synthetase alpha subunit
A6E01_RS13010	COG0751	glycine-tRNA ligase activity
A6E01_RS13015	COG3977	Valine--pyruvate aminotransferase
A6E01_RS13035	COG0071	Belongs to the small heat shock protein (HSP20) family
A6E01_RS13040	COG0187	DNA topoisomerase II activity
A6E01_RS13045	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A6E01_RS13050	COG0592	DNA-directed DNA polymerase activity
A6E01_RS13105	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A6E01_RS13295	COG3072	Adenylate cyclase
A6E01_RS13875	COG0859	PFAM glycosyl transferase family 9
A6E01_RS14025	COG0165	Argininosuccinate lyase
A6E01_RS14025	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
A6E01_RS14175	COG0488	(ABC) transporter
A6E01_RS14425	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A6E01_RS14435	COG1289	transmembrane transporter activity
A6E01_RS14445	COG3610	response to peptide
A6E01_RS14480	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
A6E01_RS15225	COG3275	phosphorelay sensor kinase activity
A6E01_RS15805	COG1609	Transcriptional regulator
A6E01_RS16015	COG1477	protein flavinylation
A6E01_RS16680	COG3300	MHYT domain
A6E01_RS16680	COG5001	Diguanylate cyclase
A6E01_RS16960	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A6E01_RS17365	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A6E01_RS17715	COG1882	Formate acetyltransferase
A6E01_RS18115	COG2850	peptidyl-arginine hydroxylation
A6E01_RS18215	COG0159	tryptophan synthase activity
A6E01_RS18240	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A6E01_RS18255	COG0613	PHP domain protein
A6E01_RS18450	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A6E01_RS18460	COG0076	glutamate decarboxylase activity
A6E01_RS18510	COG0247	lactate metabolic process
A6E01_RS18510	COG0277	FAD linked oxidase domain protein
A6E01_RS18555	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A6E01_RS18865	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A6E01_RS18965	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A6E01_RS18975	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A6E01_RS19055	COG0606	chelatase, subunit chli
A6E01_RS19215	COG3072	Adenylate cyclase
A6E01_RS19345	COG0339	signal peptide processing
A6E01_RS19675	COG3031	protein transport across the cell outer membrane
A6E01_RS19795	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A6E01_RS19880	COG1086	Polysaccharide biosynthesis protein
A6E01_RS19960	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
A6E01_RS19965	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
A6E01_RS19970	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A6E01_RS19980	COG1609	Transcriptional regulator
A6E01_RS20040	COG0460	homoserine dehydrogenase
A6E01_RS20040	COG0527	aspartate kinase activity
A6E01_RS20055	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
A6E01_RS20235	COG1012	belongs to the aldehyde dehydrogenase family
A6E01_RS20290	COG0475	glutathione-regulated potassium exporter activity
A6E01_RS20290	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A6E01_RS20430	COG0201	protein transport
A6E01_RS20505	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A6E01_RS20505	COG1648	precorrin-2 dehydrogenase activity
A6E01_RS20530	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
A6E01_RS20710	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity