locus-tag	class	description
M892_RS00010	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
M892_RS00030	COG3335	DDE superfamily endonuclease
M892_RS00045	COG3335	DDE superfamily endonuclease
M892_RS00055	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
M892_RS00060	COG0626	cystathionine gamma-synthase activity
M892_RS00070	COG0733	neurotransmitter:sodium symporter activity
M892_RS00080	COG0564	pseudouridine synthase activity
M892_RS00090	COG3335	DDE superfamily endonuclease
M892_RS00095	COG1151	hydroxylamine reductase activity
M892_RS00100	COG3604	Transcriptional regulator
M892_RS00110	COG2814	Major facilitator Superfamily
M892_RS00120	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M892_RS00125	COG4136	ATPase activity
M892_RS00130	COG4135	transport system, permease component
M892_RS00135	COG4134	Bacterial extracellular solute-binding protein
M892_RS00140	COG0398	Pfam SNARE associated Golgi protein
M892_RS00175	COG0659	secondary active sulfate transmembrane transporter activity
M892_RS00185	COG3313	Fe-S protein
M892_RS00240	COG1061	Type III restriction enzyme res subunit
M892_RS00245	COG1187	pseudouridine synthase activity
M892_RS00250	COG2814	Major facilitator Superfamily
M892_RS00260	COG3344	reverse transcriptase
M892_RS00265	COG0702	epimerase
M892_RS00270	COG0534	Mate efflux family protein
M892_RS00275	COG4181	ATPase activity
M892_RS00300	COG2433	Pfam Transposase IS66
M892_RS00330	COG1960	acyl-CoA dehydrogenase activity
M892_RS00335	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
M892_RS00345	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M892_RS00355	COG1737	Transcriptional regulator
M892_RS00360	COG0076	glutamate decarboxylase activity
M892_RS00370	COG2431	L-lysine efflux transmembrane transporter activity
M892_RS00380	COG3070	regulator of competence-specific genes
M892_RS00395	COG4191	Histidine kinase
M892_RS00395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M892_RS00405	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
M892_RS00420	COG5001	Diguanylate cyclase
M892_RS00440	COG3293	Transposase
M892_RS00450	COG2200	EAL domain
M892_RS00455	COG3293	Transposase
M892_RS00470	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
M892_RS00475	COG4988	ABC transporter
M892_RS00480	COG0492	ferredoxin-NADP+ reductase activity
M892_RS00485	COG3335	DDE superfamily endonuclease
M892_RS00495	COG3547	Transposase (IS116 IS110 IS902 family)
M892_RS00535	COG3547	Transposase (IS116 IS110 IS902 family)
M892_RS00565	COG3344	reverse transcriptase
M892_RS00630	COG3340	Belongs to the peptidase S51 family
M892_RS00660	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M892_RS00675	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
M892_RS00675	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
M892_RS00690	COG1609	Transcriptional regulator
M892_RS00700	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M892_RS00715	COG0596	Alpha beta hydrolase
M892_RS00730	COG3335	DDE superfamily endonuclease
M892_RS00760	COG1280	lysine exporter protein (LysE YggA)
M892_RS00765	COG1328	CTP reductase activity
M892_RS00770	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
M892_RS00780	COG0861	Integral membrane protein TerC family
M892_RS00795	COG4221	oxidoreductase activity
M892_RS00800	COG1454	alcohol dehydrogenase
M892_RS00805	COG0814	amino acid
M892_RS00825	COG1132	(ABC) transporter
M892_RS00830	COG1132	(ABC) transporter
M892_RS00835	COG2165	general secretion pathway protein
M892_RS00850	COG0443	Heat shock 70 kDa protein
M892_RS00855	COG0443	Heat shock 70 kDa protein
M892_RS00865	COG3706	GGDEF domain
M892_RS00900	COG3227	Zinc metalloprotease (Elastase)
M892_RS00910	COG0243	molybdopterin cofactor binding
M892_RS00915	COG0437	4 iron, 4 sulfur cluster binding
M892_RS00920	COG3302	dmso reductase anchor subunit
M892_RS00935	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
M892_RS00940	COG1643	Atp-dependent helicase
M892_RS00975	COG3063	Type IV pilus biogenesis stability protein PilW
M892_RS00990	COG3344	reverse transcriptase
M892_RS01015	COG0531	amino acid
M892_RS01020	COG1280	lysine exporter protein (LysE YggA)
M892_RS01025	COG1560	Kdo2-lipid A biosynthetic process
M892_RS01050	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
M892_RS01055	COG1280	lysine exporter protein (LysE YggA)
M892_RS01090	COG1115	amino acid carrier protein
M892_RS01115	COG1368	sulfuric ester hydrolase activity
M892_RS01120	COG3335	DDE superfamily endonuclease
M892_RS01135	COG0215	cysteine-tRNA ligase activity
M892_RS01145	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
M892_RS01155	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M892_RS01160	COG0456	acetyltransferase
M892_RS01165	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M892_RS01175	COG0527	aspartate kinase activity
M892_RS01185	COG1858	cytochrome C peroxidase
M892_RS01190	COG1404	Belongs to the peptidase S8 family
M892_RS01220	COG2433	Pfam Transposase IS66
M892_RS01255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M892_RS01275	COG3290	protein histidine kinase activity
M892_RS01280	COG4565	transcriptional regulatory protein
M892_RS01285	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
M892_RS01290	COG0363	glucosamine-6-phosphate deaminase activity
M892_RS01295	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
M892_RS01300	COG3344	reverse transcriptase
M892_RS01315	COG3284	Transcriptional regulator
M892_RS01320	COG1012	belongs to the aldehyde dehydrogenase family
M892_RS01325	COG2358	TRAP transporter, solute receptor (TAXI family
M892_RS01330	COG0840	transmembrane signaling receptor activity
M892_RS01335	COG0730	response to heat
M892_RS01390	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
M892_RS01430	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
M892_RS01435	COG0372	Belongs to the citrate synthase family
M892_RS01445	COG2828	Protein conserved in bacteria
M892_RS01460	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
M892_RS01480	COG0561	phosphatase activity
M892_RS01485	COG0602	queuosine metabolic process
M892_RS01495	COG3706	GGDEF domain
M892_RS01520	COG2433	Pfam Transposase IS66
M892_RS01570	COG2920	part of a sulfur-relay system
M892_RS01575	COG0670	Belongs to the BI1 family
M892_RS01580	COG1126	abc transporter atp-binding protein
M892_RS01590	COG4597	amino acid ABC transporter
M892_RS01595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M892_RS01610	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M892_RS01635	COG3008	intermembrane lipid transfer
M892_RS01640	COG2995	paraquat-inducible protein a
M892_RS01650	COG1956	GAF domain-containing protein
M892_RS01655	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
M892_RS01670	COG0308	aminopeptidase N
M892_RS01680	COG2902	Dehydrogenase
M892_RS01690	COG1484	DNA-dependent DNA replication
M892_RS01720	COG0488	(ABC) transporter
M892_RS01845	COG0784	Response regulator, receiver
M892_RS01845	COG2205	protein histidine kinase activity
M892_RS01860	COG3278	Belongs to the heme-copper respiratory oxidase family
M892_RS01875	COG2010	Cytochrome c
M892_RS01900	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M892_RS01905	COG0589	response to stress
M892_RS01940	COG1177	transmembrane transport
M892_RS01955	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
M892_RS01975	COG0437	4 iron, 4 sulfur cluster binding
M892_RS01980	COG3383	formate dehydrogenase (NAD+) activity
M892_RS01980	COG0243	molybdopterin cofactor binding
M892_RS01990	COG3381	protein complex oligomerization
M892_RS02010	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
M892_RS02020	COG0488	(ABC) transporter
M892_RS02035	COG4191	Histidine kinase
M892_RS02040	COG2204	response regulator
M892_RS02050	COG4662	Binding-protein-dependent transport system inner membrane component
M892_RS02055	COG3842	ATPase activity
M892_RS02065	COG0303	'Molybdopterin
M892_RS02080	COG1940	carbohydrate kinase activity
M892_RS02085	COG3148	PFAM DTW domain containing protein
M892_RS02125	COG3344	reverse transcriptase
M892_RS02140	COG0840	transmembrane signaling receptor activity
M892_RS02145	COG0791	NLP P60 protein
M892_RS02155	COG3706	GGDEF domain
M892_RS02160	COG2201	protein-glutamate methylesterase activity
M892_RS02175	COG0307	riboflavin synthase, alpha
M892_RS02180	COG0534	Mate efflux family protein
M892_RS02200	COG2885	chlorophyll binding
M892_RS02220	COG2204	response regulator
M892_RS02225	COG0438	transferase activity, transferring glycosyl groups
M892_RS02230	COG0438	transferase activity, transferring glycosyl groups
M892_RS02260	COG0438	transferase activity, transferring glycosyl groups
M892_RS02265	COG1215	transferase activity, transferring glycosyl groups
M892_RS02270	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M892_RS02295	COG3300	MHYT domain
M892_RS02295	COG5001	Diguanylate cyclase
M892_RS02300	COG4999	Histidine kinase
M892_RS02300	COG3850	Histidine kinase
M892_RS02300	COG3437	response regulator, receiver
M892_RS02300	COG2205	protein histidine kinase activity
M892_RS02320	COG0110	maltose O-acetyltransferase activity
M892_RS02325	COG0784	Response regulator, receiver
M892_RS02325	COG2205	protein histidine kinase activity
M892_RS02350	COG1846	Transcriptional regulator
M892_RS02365	COG3247	response to pH
M892_RS02370	COG0668	transmembrane transport
M892_RS02390	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
M892_RS02450	COG0625	glutathione transferase activity
M892_RS02460	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
M892_RS02475	COG3335	DDE superfamily endonuclease
M892_RS02480	COG2195	Cleaves the N-terminal amino acid of tripeptides
M892_RS02495	COG3335	DDE superfamily endonuclease
M892_RS02565	COG3335	DDE superfamily endonuclease
M892_RS02615	COG1451	nucleotide metabolic process
M892_RS02625	COG2433	Pfam Transposase IS66
M892_RS02640	COG0583	DNA-binding transcription factor activity
M892_RS02665	COG3335	DDE superfamily endonuclease
M892_RS02675	COG4139	cobalamin transport
M892_RS02690	COG2062	phosphohistidine phosphatase, SixA
M892_RS02700	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
M892_RS02715	COG0702	epimerase
M892_RS02720	COG1823	symporter activity
M892_RS02730	COG2925	Exonuclease
M892_RS02740	COG1346	cytolysis
M892_RS02785	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M892_RS02790	COG4605	iron ion homeostasis
M892_RS02795	COG4607	ABC-type enterochelin transport system periplasmic component
M892_RS02800	COG4774	siderophore transport
M892_RS02820	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M892_RS02830	COG2375	cellular response to nickel ion
M892_RS02830	COG1132	(ABC) transporter
M892_RS02835	COG1132	(ABC) transporter
M892_RS02840	COG1535	isochorismatase
M892_RS02840	COG3433	isochorismatase activity
M892_RS02855	COG2433	Pfam Transposase IS66
M892_RS02860	COG0072	phenylalanine-tRNA ligase activity
M892_RS02860	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M892_RS02885	COG0251	oxidation-reduction process
M892_RS02905	COG2433	Pfam Transposase IS66
M892_RS02950	COG0010	Belongs to the arginase family
M892_RS02960	COG2986	histidine ammonia-lyase
M892_RS03005	COG0247	lactate metabolic process
M892_RS03005	COG0277	FAD linked oxidase domain protein
M892_RS03060	COG2433	Pfam Transposase IS66
M892_RS03140	COG1643	Atp-dependent helicase
M892_RS03150	COG2949	membrane
M892_RS03155	COG0471	metal ion transport
M892_RS03175	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M892_RS03195	COG3335	DDE superfamily endonuclease
M892_RS03215	COG2433	Pfam Transposase IS66
M892_RS03235	COG3344	reverse transcriptase
M892_RS03380	COG1030	water channel activity
M892_RS03410	COG3772	lysozyme
M892_RS03465	COG1403	HNH endonuclease
M892_RS03485	COG4626	Terminase
M892_RS03485	COG1802	Transcriptional regulator
M892_RS03505	COG3620	sequence-specific DNA binding
M892_RS03520	COG5532	Uncharacterized conserved protein (DUF2303)
M892_RS03535	COG0582	viral genome integration into host DNA
M892_RS03585	COG2433	Pfam Transposase IS66
M892_RS03610	COG2433	Pfam Transposase IS66
M892_RS03655	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M892_RS03670	COG3106	COG3106 Predicted ATPase
M892_RS03685	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M892_RS03705	COG0814	amino acid
M892_RS03710	COG1760	l-serine dehydratase
M892_RS03715	COG3385	transposase activity
M892_RS03730	COG2197	response regulator
M892_RS03735	COG0720	synthase
M892_RS03745	COG0017	Asparaginyl-tRNA synthetase
M892_RS03760	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M892_RS03775	COG2770	Histidine kinase
M892_RS03775	COG3437	response regulator, receiver
M892_RS03780	COG1448	Aminotransferase
M892_RS03805	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M892_RS03810	COG1846	Transcriptional regulator
M892_RS03820	COG3335	DDE superfamily endonuclease
M892_RS03830	COG2818	Glycosylase
M892_RS03850	COG1983	PspC domain protein
M892_RS03860	COG1842	Phage shock protein A
M892_RS03865	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
M892_RS03875	COG4168	peptide transport system, permease
M892_RS03880	COG4171	peptide transport system, permease
M892_RS03890	COG4172	Belongs to the ABC transporter superfamily
M892_RS03920	COG1227	inorganic diphosphatase activity
M892_RS03935	COG0243	molybdopterin cofactor binding
M892_RS03945	COG4459	periplasmic nitrate reductase
M892_RS03950	COG0390	transport system, permease component
M892_RS03955	COG2116	formate transmembrane transporter activity
M892_RS03980	COG1434	Gram-negative-bacterium-type cell wall biogenesis
M892_RS03985	COG3344	reverse transcriptase
M892_RS04000	COG1435	thymidine kinase activity
M892_RS04005	COG0215	cysteine-tRNA ligase activity
M892_RS04010	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M892_RS04015	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M892_RS04020	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
M892_RS04025	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
M892_RS04030	COG3012	SEC-C Motif Domain Protein
M892_RS04035	COG0140	phosphoribosyl-ATP diphosphatase activity
M892_RS04035	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
M892_RS04050	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
M892_RS04055	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
M892_RS04055	COG0131	Imidazoleglycerol-phosphate dehydratase
M892_RS04065	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M892_RS04075	COG1757	Na H antiporter
M892_RS04085	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M892_RS04105	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M892_RS04125	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
M892_RS04140	COG0300	oxidoreductase activity
M892_RS04155	COG3344	reverse transcriptase
M892_RS04165	COG2226	methyltransferase
M892_RS04185	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M892_RS04205	COG3335	DDE superfamily endonuclease
M892_RS04215	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M892_RS04225	COG1674	ftsk spoiiie
M892_RS04235	COG0686	Belongs to the AlaDH PNT family
M892_RS04260	COG3547	Transposase (IS116 IS110 IS902 family)
M892_RS04275	COG0402	S-adenosylhomocysteine deaminase activity
M892_RS04295	COG2433	Pfam Transposase IS66
M892_RS04320	COG3568	Endonuclease Exonuclease Phosphatase
M892_RS04355	COG3293	Transposase
M892_RS04370	COG1120	ATPase activity
M892_RS04375	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M892_RS04400	COG1288	antiporter activity
M892_RS04410	COG2186	Transcriptional regulator
M892_RS04420	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M892_RS04425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M892_RS04440	COG2824	Alkylphosphonate utilization operon protein PhnA
M892_RS04460	COG3385	transposase activity
M892_RS04490	COG0457	Tetratricopeptide repeat
M892_RS04560	COG4790	Type iii secretion
M892_RS04565	COG4794	Type iii secretion
M892_RS04570	COG4791	protein targeting
M892_RS04575	COG4792	protein secretion
M892_RS04580	COG0583	DNA-binding transcription factor activity
M892_RS04600	COG3335	DDE superfamily endonuclease
M892_RS04610	COG3335	DDE superfamily endonuclease
M892_RS04615	COG3335	DDE superfamily endonuclease
M892_RS04620	COG3177	Filamentation induced by cAMP protein fic
M892_RS04650	COG4669	(LipO)protein
M892_RS04745	COG3385	transposase activity
M892_RS04815	COG5433	transposase activity
M892_RS04850	COG3335	DDE superfamily endonuclease
M892_RS04865	COG2433	Pfam Transposase IS66
M892_RS04910	COG2433	Pfam Transposase IS66
M892_RS04915	COG3335	DDE superfamily endonuclease
M892_RS04960	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M892_RS04965	COG4689	acetoacetate decarboxylase
M892_RS04970	COG3426	butyrate kinase activity
M892_RS04975	COG0280	phosphate acetyltransferase
M892_RS04995	COG2433	Pfam Transposase IS66
M892_RS05010	COG0582	viral genome integration into host DNA
M892_RS05025	COG0784	Response regulator, receiver
M892_RS05025	COG2205	protein histidine kinase activity
M892_RS05035	COG0754	glutathionylspermidine amidase activity
M892_RS05045	COG3766	membrane
M892_RS05060	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
M892_RS05065	COG2885	chlorophyll binding
M892_RS05070	COG0823	Involved in the tonB-independent uptake of proteins
M892_RS05085	COG0811	peptide transport
M892_RS05090	COG0824	Thioesterase
M892_RS05105	COG1294	oxidase, subunit
M892_RS05110	COG1271	oxidase subunit
M892_RS05120	COG0632	four-way junction helicase activity
M892_RS05125	COG0840	transmembrane signaling receptor activity
M892_RS05140	COG1801	Protein of unknown function DUF72
M892_RS05155	COG4067	protein conserved in archaea
M892_RS05155	COG0189	ligase activity
M892_RS05170	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
M892_RS05175	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
M892_RS05185	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M892_RS05190	COG1434	Gram-negative-bacterium-type cell wall biogenesis
M892_RS05195	COG3385	transposase activity
M892_RS05200	COG0745	RESPONSE REGULATOR receiver
M892_RS05215	COG3070	regulator of competence-specific genes
M892_RS05235	COG0297	glycogen (starch) synthase activity
M892_RS05240	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
M892_RS05245	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M892_RS05275	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
M892_RS05280	COG0542	response to heat
M892_RS05290	COG1278	Cold shock
M892_RS05300	COG1187	pseudouridine synthase activity
M892_RS05305	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
M892_RS05315	COG1199	ATP-dependent helicase activity
M892_RS05320	COG0730	response to heat
M892_RS05325	COG3923	Primosomal replication protein n
M892_RS05335	COG0708	Exodeoxyribonuclease III
M892_RS05370	COG1882	Formate acetyltransferase
M892_RS05380	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
M892_RS05395	COG2766	serine protein kinase
M892_RS05400	COG2718	Belongs to the UPF0229 family
M892_RS05405	COG2719	SpoVR family
M892_RS05425	COG1132	(ABC) transporter
M892_RS05430	COG0658	competence protein
M892_RS05430	COG2333	competence protein COMEC
M892_RS05440	COG4591	ABC-type transport system involved in lipoprotein release permease component
M892_RS05445	COG1136	(ABC) transporter
M892_RS05450	COG4591	ABC-type transport system involved in lipoprotein release permease component
M892_RS05460	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M892_RS05475	COG1252	NADH dehydrogenase
M892_RS05505	COG0537	adenosine 5'-monophosphoramidase activity
M892_RS05525	COG2217	Heavy metal translocating P-type atpase
M892_RS05535	COG0516	GMP reductase activity
M892_RS05535	COG0517	IMP dehydrogenase activity
M892_RS05540	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
M892_RS05545	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
M892_RS05550	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M892_RS05630	COG2433	Pfam Transposase IS66
M892_RS05635	COG4372	Transposase
M892_RS05650	COG2433	Pfam Transposase IS66
M892_RS05660	COG4372	Transposase
M892_RS05775	COG3706	GGDEF domain
M892_RS05790	COG3126	Type III secretion system lipoprotein chaperone (YscW)
M892_RS05795	COG1946	Acyl-CoA thioesterase
M892_RS05800	COG1522	sequence-specific DNA binding
M892_RS05820	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M892_RS05825	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M892_RS05855	COG2855	membrane
M892_RS05880	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
M892_RS05885	COG0596	Alpha beta hydrolase
M892_RS05895	COG1169	isochorismate synthase
M892_RS05900	COG0436	Aminotransferase
M892_RS05905	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
M892_RS05925	COG1555	photosystem II stabilization
M892_RS05930	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M892_RS05935	COG0776	regulation of translation
M892_RS05940	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
M892_RS05970	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
M892_RS05985	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M892_RS05990	COG0569	domain protein
M892_RS05995	COG0513	Belongs to the DEAD box helicase family
M892_RS06000	COG4771	TonB-dependent receptor
M892_RS06005	COG2977	Belongs to the P-Pant transferase superfamily
M892_RS06015	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M892_RS06015	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M892_RS06020	COG3433	isochorismatase activity
M892_RS06020	COG1535	isochorismatase
M892_RS06025	COG1021	2,3-dihydroxybenzoate-AMP ligase
M892_RS06030	COG1169	isochorismate synthase
M892_RS06040	COG1028	Short-chain dehydrogenase reductase Sdr
M892_RS06070	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M892_RS06080	COG2951	lytic endotransglycosylase activity
M892_RS06095	COG2894	cell division
M892_RS06100	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
M892_RS06110	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
M892_RS06115	COG0318	PFAM AMP-dependent synthetase and ligase
M892_RS06120	COG2267	carboxylic ester hydrolase activity
M892_RS06125	COG3065	identical protein binding
M892_RS06135	COG1214	PFAM Peptidase M22, glycoprotease
M892_RS06140	COG1199	ATP-dependent helicase activity
M892_RS06145	COG0788	formyltetrahydrofolate deformylase activity
M892_RS06160	COG3102	Protein conserved in bacteria
M892_RS06190	COG1918	ferrous iron import across plasma membrane
M892_RS06195	COG4977	sequence-specific DNA binding
M892_RS06200	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
M892_RS06205	COG1121	(ABC) transporter
M892_RS06210	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M892_RS06225	COG0508	dehydrogenase complex catalyzes the overall conversion of
M892_RS06230	COG0567	Dehydrogenase, E1 component
M892_RS06240	COG1053	succinate dehydrogenase
M892_RS06245	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
M892_RS06260	COG3547	Transposase (IS116 IS110 IS902 family)
M892_RS06265	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
M892_RS06275	COG0033	Phosphoglucomutase
M892_RS06280	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
M892_RS06285	COG0596	Alpha beta hydrolase
M892_RS06305	COG0735	belongs to the Fur family
M892_RS06310	COG2165	general secretion pathway protein
M892_RS06320	COG1263	PTS System
M892_RS06320	COG2190	(PTS) system
M892_RS06320	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M892_RS06325	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
M892_RS06330	COG1846	Transcriptional regulator
M892_RS06330	COG1940	carbohydrate kinase activity
M892_RS06335	COG4651	solute:proton antiporter activity
M892_RS06335	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M892_RS06340	COG0367	asparagine synthase
M892_RS06350	COG3104	oligopeptide transport
M892_RS06355	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
M892_RS06370	COG3710	Transcriptional regulator
M892_RS06390	COG0622	Phosphoesterase
M892_RS06400	COG1090	epimerase
M892_RS06405	COG0300	oxidoreductase activity
M892_RS06410	COG3118	belongs to the thioredoxin family
M892_RS06415	COG0330	HflC and HflK could
M892_RS06450	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
M892_RS06455	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M892_RS06460	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M892_RS06465	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M892_RS06470	COG2190	(PTS) system
M892_RS06475	COG3344	reverse transcriptase
M892_RS06480	COG3335	DDE superfamily endonuclease
M892_RS06490	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M892_RS06495	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M892_RS06500	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M892_RS06515	COG3344	reverse transcriptase
M892_RS06520	COG1705	Flagellar rod assembly protein muramidase FlgJ
M892_RS06520	COG3951	Flagellar rod assembly protein muramidase FlgJ
M892_RS06525	COG1706	bacterial-type flagellum-dependent cell motility
M892_RS06530	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
M892_RS06540	COG4787	bacterial-type flagellum-dependent cell motility
M892_RS06545	COG1749	Flagellar hook protein flgE
M892_RS06555	COG1558	bacterial-type flagellum-dependent cell motility
M892_RS06560	COG1815	bacterial-type flagellum-dependent cell motility
M892_RS06565	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
M892_RS06570	COG0835	chemotaxis
M892_RS06570	COG0784	Response regulator, receiver
M892_RS06630	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
M892_RS06640	COG2217	Heavy metal translocating P-type atpase
M892_RS06640	COG2608	mercury ion transmembrane transporter activity
M892_RS06690	COG2840	Smr protein MutS2
M892_RS06695	COG1187	pseudouridine synthase activity
M892_RS06700	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M892_RS06705	COG0737	Belongs to the 5'-nucleotidase family
M892_RS06715	COG2912	Transglutaminase-like superfamily
M892_RS06720	COG3094	Invasion gene expression up-regulator, SirB
M892_RS06725	COG2890	protein-(glutamine-N5) methyltransferase activity
M892_RS06750	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M892_RS06760	COG0012	GTP binding
M892_RS06785	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M892_RS06795	COG1702	phosphate starvation-inducible protein PhoH
M892_RS06805	COG4535	Mg2 and Co2 transporter CorC
M892_RS06810	COG0815	Transfers the fatty acyl group on membrane lipoproteins
M892_RS06820	COG2888	peptidyl-tyrosine sulfation
M892_RS06830	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
M892_RS06835	COG1466	dna polymerase III delta subunit
M892_RS06840	COG0799	negative regulation of ribosome biogenesis
M892_RS06850	COG0768	penicillin binding
M892_RS06855	COG0772	Belongs to the SEDS family
M892_RS06860	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M892_RS06865	COG1686	Belongs to the peptidase S11 family
M892_RS06885	COG3547	Transposase (IS116 IS110 IS902 family)
M892_RS06890	COG3547	Transposase (IS116 IS110 IS902 family)
M892_RS06895	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M892_RS06900	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M892_RS06905	COG0366	Alpha amylase catalytic
M892_RS06910	COG1263	PTS System
M892_RS06910	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M892_RS06920	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
M892_RS06925	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M892_RS06930	COG2011	ABC-type metal ion transport system permease component
M892_RS06935	COG1464	Belongs to the NlpA lipoprotein family
M892_RS06950	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
M892_RS06975	COG1611	Belongs to the LOG family
M892_RS06995	COG2363	Small membrane protein
M892_RS07005	COG0583	DNA-binding transcription factor activity
M892_RS07010	COG2433	Pfam Transposase IS66
M892_RS07035	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
M892_RS07045	COG0142	geranyltranstransferase activity
M892_RS07055	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
M892_RS07060	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
M892_RS07085	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M892_RS07085	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M892_RS07090	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
M892_RS07095	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
M892_RS07110	COG1073	alpha beta
M892_RS07120	COG2252	PERMEase
M892_RS07125	COG2195	Cleaves the N-terminal amino acid of tripeptides
M892_RS07130	COG3385	transposase activity
M892_RS07150	COG3293	Transposase
M892_RS07160	COG0047	phosphoribosylformylglycinamidine synthase activity
M892_RS07160	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M892_RS07170	COG2433	Pfam Transposase IS66
M892_RS07180	COG2433	Pfam Transposase IS66
M892_RS07195	COG0590	tRNA wobble adenosine to inosine editing
M892_RS07200	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
M892_RS07240	COG1301	dicarboxylic acid transport
M892_RS07255	COG0497	DNA recombination
M892_RS07260	COG0456	acetyltransferase
M892_RS07265	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M892_RS07280	COG2914	Belongs to the UPF0125 (RnfH) family
M892_RS07285	COG2867	negative regulation of translational initiation
M892_RS07295	COG0582	viral genome integration into host DNA
M892_RS07310	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
M892_RS07315	COG3385	transposase activity
M892_RS07365	COG0583	DNA-binding transcription factor activity
M892_RS07370	COG1289	transmembrane transporter activity
M892_RS07385	COG2433	Pfam Transposase IS66
M892_RS07440	COG3344	reverse transcriptase
M892_RS07445	COG3335	DDE superfamily endonuclease
M892_RS07450	COG0668	transmembrane transport
M892_RS07455	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M892_RS07460	COG0583	DNA-binding transcription factor activity
M892_RS07470	COG1115	amino acid carrier protein
M892_RS07475	COG3344	reverse transcriptase
M892_RS07480	COG1584	GPR1 FUN34 yaaH family protein
M892_RS07490	COG1757	Na H antiporter
M892_RS07505	COG1757	Na H antiporter
M892_RS07515	COG0516	GMP reductase activity
M892_RS07515	COG0517	IMP dehydrogenase activity
M892_RS07540	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M892_RS07545	COG2976	Protein conserved in bacteria
M892_RS07580	COG3385	transposase activity
M892_RS07585	COG2975	iron-sulfur cluster assembly
M892_RS07590	COG0633	Ferredoxin
M892_RS07605	COG0316	Belongs to the HesB IscA family
M892_RS07610	COG0822	iron-sulfur transferase activity
M892_RS07625	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
M892_RS07645	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M892_RS07650	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M892_RS07655	COG1862	Preprotein translocase
M892_RS07675	COG0517	IMP dehydrogenase activity
M892_RS07685	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
M892_RS07690	COG0583	DNA-binding transcription factor activity
M892_RS07695	COG0450	alkyl hydroperoxide reductase
M892_RS07710	COG3335	DDE superfamily endonuclease
M892_RS07720	COG0704	Plays a role in the regulation of phosphate uptake
M892_RS07725	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M892_RS07730	COG0581	inorganic phosphate transmembrane transporter activity
M892_RS07735	COG0573	inorganic phosphate transmembrane transporter activity
M892_RS07740	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
M892_RS07745	COG0248	Ppx GppA phosphatase
M892_RS07755	COG5002	protein histidine kinase activity
M892_RS07760	COG0745	RESPONSE REGULATOR receiver
M892_RS07770	COG0826	peptidase U32
M892_RS07775	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M892_RS07800	COG3335	DDE superfamily endonuclease
M892_RS07810	COG3335	DDE superfamily endonuclease
M892_RS07855	COG0542	response to heat
M892_RS07860	COG1496	oxidoreductase activity
M892_RS07865	COG0564	pseudouridine synthase activity
M892_RS07870	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M892_RS07875	COG0741	lytic transglycosylase activity
M892_RS07880	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
M892_RS07885	COG0077	Prephenate dehydratase
M892_RS07885	COG1605	Chorismate mutase
M892_RS07890	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
M892_RS07905	COG0488	(ABC) transporter
M892_RS07915	COG0739	heme binding
M892_RS07925	COG1605	Chorismate mutase
M892_RS07925	COG0287	Prephenate dehydrogenase
M892_RS07930	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M892_RS07940	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
M892_RS07960	COG1966	Carbon starvation protein
M892_RS07965	COG3275	phosphorelay sensor kinase activity
M892_RS07970	COG3279	Response regulator of the LytR AlgR family
M892_RS07975	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
M892_RS07980	COG1047	Peptidyl-prolyl cis-trans
M892_RS07995	COG0196	riboflavin kinase activity
M892_RS08000	COG0728	peptidoglycan biosynthetic process
M892_RS08005	COG0268	Binds directly to 16S ribosomal RNA
M892_RS08010	COG0640	Transcriptional regulator
M892_RS08015	COG0583	DNA-binding transcription factor activity
M892_RS08020	COG1283	sodium-dependent phosphate transmembrane transporter activity
M892_RS08040	COG0730	response to heat
M892_RS08065	COG0667	Aldo Keto reductase
M892_RS08085	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
M892_RS08090	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M892_RS08095	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M892_RS08100	COG4974	Belongs to the 'phage' integrase family
M892_RS08105	COG0716	FMN binding
M892_RS08120	COG0513	Belongs to the DEAD box helicase family
M892_RS08135	COG3022	response to hydroperoxide
M892_RS08140	COG1115	amino acid carrier protein
M892_RS08175	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
M892_RS08180	COG0083	homoserine kinase activity
M892_RS08195	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M892_RS08205	COG3385	transposase activity
M892_RS08210	COG0745	RESPONSE REGULATOR receiver
M892_RS08220	COG2198	Histidine kinase
M892_RS08220	COG5002	protein histidine kinase activity
M892_RS08220	COG0784	Response regulator, receiver
M892_RS08225	COG5001	Diguanylate cyclase
M892_RS08225	COG2203	Gaf domain
M892_RS08225	COG3706	GGDEF domain
M892_RS08225	COG4251	negative regulation of phosphorylation
M892_RS08230	COG1242	4 iron, 4 sulfur cluster binding
M892_RS08235	COG0067	glutamate synthase
M892_RS08235	COG0070	glutamate synthase
M892_RS08235	COG0069	glutamate synthase activity
M892_RS08245	COG0067	glutamate synthase
M892_RS08245	COG0070	glutamate synthase
M892_RS08245	COG0069	glutamate synthase activity
M892_RS08250	COG0493	'glutamate synthase
M892_RS08275	COG2860	membrane
M892_RS08280	COG0583	DNA-binding transcription factor activity
M892_RS08285	COG0730	response to heat
M892_RS08300	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M892_RS08305	COG0505	Belongs to the CarA family
M892_RS08315	COG0494	nUDIX hydrolase
M892_RS08335	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
M892_RS08340	COG0849	cell division
M892_RS08345	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
M892_RS08360	COG0772	Belongs to the SEDS family
M892_RS08375	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M892_RS08380	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M892_RS08385	COG0768	penicillin binding
M892_RS08390	COG3116	cell division
M892_RS08400	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
M892_RS08415	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
M892_RS08420	COG2823	Periplasmic or secreted lipoprotein
M892_RS08425	COG2969	positive regulation of protein catabolic process
M892_RS08430	COG0625	glutathione transferase activity
M892_RS08435	COG2857	Cytochrome c1
M892_RS08440	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
M892_RS08445	COG0723	plastoquinol--plastocyanin reductase activity
M892_RS08460	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
M892_RS08465	COG3105	Protein conserved in bacteria
M892_RS08470	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M892_RS08475	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M892_RS08480	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M892_RS08490	COG3150	esterase
M892_RS08500	COG3151	Protein conserved in bacteria
M892_RS08505	COG0494	nUDIX hydrolase
M892_RS08510	COG1538	Outer membrane efflux protein
M892_RS08520	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
M892_RS08530	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M892_RS08535	COG3025	triphosphatase activity
M892_RS08540	COG1392	Phosphate transport regulator
M892_RS08545	COG0306	phosphate transporter
M892_RS08550	COG4991	sh3 domain protein
M892_RS08560	COG3267	Type II secretory pathway component ExeA
M892_RS08560	COG3409	Peptidoglycan-binding domain 1 protein
M892_RS08575	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M892_RS08580	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
M892_RS08590	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M892_RS08595	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
M892_RS08600	COG0828	Belongs to the bacterial ribosomal protein bS21 family
M892_RS08605	COG1610	YqeY-like protein
M892_RS08610	COG0358	DNA primase activity
M892_RS08635	COG2433	Pfam Transposase IS66
M892_RS08655	COG0582	viral genome integration into host DNA
M892_RS08680	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
M892_RS08680	COG2213	PTS system mannitol-specific
M892_RS08690	COG3722	fumarate hydratase activity
M892_RS08695	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M892_RS08700	COG1349	DNA-binding transcription factor activity
M892_RS08705	COG0469	pyruvate kinase activity
M892_RS08715	COG3706	GGDEF domain
M892_RS08720	COG0440	acetolactate synthase activity
M892_RS08725	COG0028	Belongs to the TPP enzyme family
M892_RS08730	COG1022	Amp-dependent synthetase and ligase
M892_RS08735	COG0583	DNA-binding transcription factor activity
M892_RS08765	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M892_RS08770	COG0473	3-isopropylmalate dehydrogenase activity
M892_RS08790	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
M892_RS08795	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
M892_RS08800	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M892_RS08805	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
M892_RS08830	COG3610	response to peptide
M892_RS08835	COG2966	Psort location CytoplasmicMembrane, score
M892_RS08850	COG0261	This protein binds to 23S rRNA in the presence of protein L20
M892_RS08855	COG0142	geranyltranstransferase activity
M892_RS08860	COG3385	transposase activity
M892_RS08880	COG2358	TRAP transporter, solute receptor (TAXI family
M892_RS08895	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
M892_RS08900	COG1178	ABC-type Fe3 transport system permease component
M892_RS08905	COG4143	(ABC) transporter
M892_RS08910	COG0163	prenyltransferase activity
M892_RS08915	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M892_RS08925	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
M892_RS08930	COG3385	transposase activity
M892_RS08940	COG2105	PFAM AIG2 family protein
M892_RS08950	COG0729	surface antigen
M892_RS08955	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M892_RS08965	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
M892_RS08975	COG1136	(ABC) transporter
M892_RS08995	COG0529	Catalyzes the synthesis of activated sulfate
M892_RS09000	COG0471	metal ion transport
M892_RS09000	COG3273	potassium ion transport
M892_RS09015	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M892_RS09015	COG1648	precorrin-2 dehydrogenase activity
M892_RS09020	COG0737	Belongs to the 5'-nucleotidase family
M892_RS09030	COG0513	Belongs to the DEAD box helicase family
M892_RS09035	COG2153	protein acetylation
M892_RS09045	COG3344	reverse transcriptase
M892_RS09055	COG0545	Peptidyl-prolyl cis-trans isomerase
M892_RS09065	COG0203	ribosomal protein L17
M892_RS09080	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
M892_RS09085	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
M892_RS09090	COG0201	protein transport
M892_RS09100	COG1841	ribosomal large subunit assembly
M892_RS09205	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M892_RS09210	COG1609	Transcriptional regulator
M892_RS09230	COG1575	Belongs to the MenA family. Type 1 subfamily
M892_RS09235	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M892_RS09245	COG1494	fructose-1,6-bisphosphatase
M892_RS09260	COG3547	Transposase (IS116 IS110 IS902 family)
M892_RS09275	COG0149	triose-phosphate isomerase activity
M892_RS09295	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M892_RS09300	COG1482	cell wall glycoprotein biosynthetic process
M892_RS09370	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
M892_RS09375	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
M892_RS09410	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M892_RS09420	COG1560	Kdo2-lipid A biosynthetic process
M892_RS09430	COG1519	Transferase
M892_RS09440	COG1083	cytidylyl-transferase
M892_RS09450	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M892_RS09470	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
M892_RS09475	COG2089	acid synthase
M892_RS09505	COG3642	lipopolysaccharide core region biosynthetic process
M892_RS09510	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
M892_RS09515	COG0859	PFAM glycosyl transferase family 9
M892_RS09520	COG0463	Glycosyl transferase, family 2
M892_RS09525	COG0438	transferase activity, transferring glycosyl groups
M892_RS09565	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M892_RS09575	COG1560	Kdo2-lipid A biosynthetic process
M892_RS09580	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
M892_RS09585	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
M892_RS09590	COG1561	YicC-like family, N-terminal region
M892_RS09610	COG4608	Belongs to the ABC transporter superfamily
M892_RS09615	COG0444	Belongs to the ABC transporter superfamily
M892_RS09620	COG0747	negative chemotaxis
M892_RS09625	COG4239	(ABC) transporter, permease
M892_RS09630	COG4174	ABC transporter (Permease)
M892_RS09650	COG0811	peptide transport
M892_RS09655	COG0848	biopolymer transport protein
M892_RS09670	COG0194	GDP metabolic process
M892_RS09680	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M892_RS09685	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M892_RS09690	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M892_RS09700	COG2233	PERMEase
M892_RS09715	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M892_RS09725	COG2183	response to ionizing radiation
M892_RS09740	COG1040	competence protein
M892_RS09750	COG0494	nUDIX hydrolase
M892_RS09755	COG1218	3'(2'),5'-bisphosphate nucleotidase
M892_RS09765	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
M892_RS09770	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
M892_RS09775	COG3156	type II secretion system protein K
M892_RS09780	COG4795	General secretion pathway protein
M892_RS09785	COG2165	general secretion pathway protein
M892_RS09790	COG2165	general secretion pathway protein
M892_RS09795	COG2165	general secretion pathway protein
M892_RS09800	COG1459	type II secretion system
M892_RS09805	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M892_RS09815	COG3031	protein transport across the cell outer membrane
M892_RS09820	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
M892_RS09840	COG0456	acetyltransferase
M892_RS09845	COG1490	D-aminoacyl-tRNA deacylase activity
M892_RS09865	COG1217	gtp-binding protein TYPA
M892_RS09875	COG0174	glutamine synthetase
M892_RS09890	COG3852	Histidine kinase
M892_RS09895	COG2204	response regulator
M892_RS09905	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
M892_RS09935	COG0218	Necessary for normal cell division and for the maintenance of normal septation
M892_RS09940	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M892_RS09940	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M892_RS09955	COG0084	hydrolase, TatD family'
M892_RS09960	COG0805	protein transport
M892_RS09965	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M892_RS09980	COG3165	ubiquinone biosynthetic process from chorismate
M892_RS09990	COG1322	Protein conserved in bacteria
M892_RS10005	COG3385	transposase activity
M892_RS10010	COG3293	Transposase
M892_RS10015	COG1910	domain protein
M892_RS10050	COG3469	chitinase activity
M892_RS10085	COG4372	Transposase
M892_RS10105	COG2081	HI0933 family
M892_RS10115	COG1528	Iron-storage protein
M892_RS10125	COG0589	response to stress
M892_RS10145	COG5001	Diguanylate cyclase
M892_RS10145	COG5002	protein histidine kinase activity
M892_RS10150	COG1522	sequence-specific DNA binding
M892_RS10165	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
M892_RS10175	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M892_RS10195	COG0800	Aldolase
M892_RS10200	COG2610	gluconate transmembrane transporter activity
M892_RS10205	COG3265	gluconokinase activity
M892_RS10210	COG0129	dihydroxy-acid dehydratase activity
M892_RS10215	COG3547	Transposase (IS116 IS110 IS902 family)
M892_RS10225	COG2076	Multidrug Resistance protein
M892_RS10230	COG0583	DNA-binding transcription factor activity
M892_RS10235	COG1609	Transcriptional regulator
M892_RS10240	COG0515	serine threonine protein kinase
M892_RS10265	COG3293	Transposase
M892_RS10290	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M892_RS10295	COG0601	transmembrane transport
M892_RS10300	COG4166	transmembrane transport
M892_RS10360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M892_RS10365	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M892_RS10370	COG2960	long-chain fatty acid transporting porin activity
M892_RS10375	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
M892_RS10380	COG0583	DNA-binding transcription factor activity
M892_RS10390	COG3335	DDE superfamily endonuclease
M892_RS10395	COG3335	DDE superfamily endonuclease
M892_RS10425	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M892_RS10430	COG1739	Uncharacterized protein family UPF0029
M892_RS10440	COG0183	Belongs to the thiolase family
M892_RS10445	COG0604	alcohol dehydrogenase
M892_RS10480	COG2119	membrane
M892_RS10495	COG3385	transposase activity
M892_RS10500	COG3977	Valine--pyruvate aminotransferase
M892_RS10505	COG0071	Belongs to the small heat shock protein (HSP20) family
M892_RS10510	COG0187	DNA topoisomerase II activity
M892_RS10520	COG0592	DNA-directed DNA polymerase activity
M892_RS10565	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M892_RS10580	COG1192	Involved in chromosome partitioning
M892_RS10585	COG1475	DNA binding
M892_RS10590	COG3312	ion transport
M892_RS10620	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
M892_RS10630	COG0355	proton-transporting ATP synthase activity, rotational mechanism
M892_RS10640	COG0765	amino acid transport
M892_RS10645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M892_RS10650	COG2814	Major facilitator Superfamily
M892_RS10655	COG0583	DNA-binding transcription factor activity
M892_RS10665	COG0129	dihydroxy-acid dehydratase activity
M892_RS10670	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M892_RS10675	COG3978	acetolactate synthase activity
M892_RS10685	COG0606	chelatase, subunit chli
M892_RS10690	COG2199	diguanylate cyclase activity
M892_RS10700	COG0204	Acyl-transferase
M892_RS10705	COG3385	transposase activity
M892_RS10710	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M892_RS10715	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M892_RS10725	COG3084	Protein conserved in bacteria
M892_RS10730	COG4326	sporulation control protein
M892_RS10735	COG1272	protein, Hemolysin III
M892_RS10745	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M892_RS10750	COG0569	domain protein
M892_RS10755	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M892_RS10755	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M892_RS10775	COG0758	DNA mediated transformation
M892_RS10790	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
M892_RS10795	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
M892_RS10820	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M892_RS10860	COG3335	DDE superfamily endonuclease
M892_RS10870	COG2132	Multicopper oxidase
M892_RS10890	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M892_RS10895	COG2104	thiamine diphosphate biosynthetic process
M892_RS10910	COG0006	proline dipeptidase activity
M892_RS10910	COG0006	proline dipeptidase activity
M892_RS10920	COG2814	Major facilitator Superfamily
M892_RS10940	COG3220	belongs to the UPF0276 family
M892_RS10950	COG0210	DNA helicase
M892_RS10955	COG3344	reverse transcriptase
M892_RS10960	COG0405	Gamma-glutamyltransferase
M892_RS10965	COG1280	lysine exporter protein (LysE YggA)
M892_RS10975	COG2962	Rard protein
M892_RS10980	COG0514	ATP-dependent DNA helicase (RecQ)
M892_RS10990	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
M892_RS10995	COG3344	reverse transcriptase
M892_RS11010	COG3118	belongs to the thioredoxin family
M892_RS11025	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
M892_RS11030	COG0633	Ferredoxin
M892_RS11070	COG3335	DDE superfamily endonuclease
M892_RS11080	COG3071	HemY protein
M892_RS11085	COG2959	enzyme of heme biosynthesis
M892_RS11090	COG1587	Uroporphyrinogen-III synthase
M892_RS11100	COG3072	Adenylate cyclase
M892_RS11115	COG0019	diaminopimelate decarboxylase activity
M892_RS11135	COG1011	Hydrolase
M892_RS11140	COG2200	EAL domain
M892_RS11140	COG2199	diguanylate cyclase activity
M892_RS11140	COG3287	FIST C domain
M892_RS11145	COG3148	PFAM DTW domain containing protein
M892_RS11160	COG0561	phosphatase activity
M892_RS11165	COG2267	carboxylic ester hydrolase activity
M892_RS11170	COG1280	lysine exporter protein (LysE YggA)
M892_RS11175	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
M892_RS11180	COG0640	Transcriptional regulator
M892_RS11185	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M892_RS11220	COG3293	Transposase
M892_RS11240	COG2095	MarC family integral membrane protein
M892_RS11250	COG0742	ribosomal rna small subunit methyltransferase
M892_RS11255	COG0552	protein localization to endoplasmic reticulum
M892_RS11260	COG2884	Cell division ATP-binding protein ftsE
M892_RS11265	COG2177	Part of the ABC transporter FtsEX involved in
M892_RS11280	COG0705	Rhomboid family
M892_RS11285	COG1580	Controls the rotational direction of flagella during chemotaxis
M892_RS11290	COG3161	chorismate lyase activity
M892_RS11305	COG2937	Belongs to the GPAT DAPAT family
M892_RS11320	COG0534	Mate efflux family protein
M892_RS11325	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M892_RS11415	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M892_RS11425	COG0812	UDP-N-acetylmuramate dehydrogenase activity
M892_RS11470	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M892_RS11475	COG0250	Participates in transcription elongation, termination and antitermination
M892_RS11490	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
M892_RS11510	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
M892_RS11515	COG2816	NAD+ diphosphatase activity
M892_RS11535	COG1573	uracil-dna glycosylase
M892_RS11545	COG3068	Protein conserved in bacteria
M892_RS11550	COG1253	flavin adenine dinucleotide binding
M892_RS11565	COG0151	Belongs to the GarS family
M892_RS11575	COG0789	Transcriptional regulator
M892_RS11580	COG3710	Transcriptional regulator
M892_RS11585	COG0531	amino acid
M892_RS11590	COG1982	Orn Lys Arg decarboxylase major
M892_RS11645	COG3335	DDE superfamily endonuclease
M892_RS11650	COG3335	DDE superfamily endonuclease
M892_RS11655	COG3335	DDE superfamily endonuclease
M892_RS11665	COG3335	DDE superfamily endonuclease
M892_RS11670	COG1484	DNA-dependent DNA replication
M892_RS11675	COG4584	PFAM Integrase catalytic
M892_RS11690	COG2433	Pfam Transposase IS66
M892_RS11700	COG2199	diguanylate cyclase activity
M892_RS11705	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
M892_RS11710	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M892_RS11720	COG0439	Biotin carboxylase
M892_RS11725	COG0511	ligase activity, forming carbon-carbon bonds
M892_RS11730	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
M892_RS11735	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M892_RS11750	COG2814	Major facilitator Superfamily
M892_RS11755	COG0784	Response regulator, receiver
M892_RS11755	COG2205	protein histidine kinase activity
M892_RS11775	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M892_RS11785	COG2095	MarC family integral membrane protein
M892_RS11795	COG4232	protein-disulfide reductase activity
M892_RS11800	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
M892_RS11805	COG1027	Aspartate ammonia-lyase
M892_RS11810	COG3030	protein affecting phage T7 exclusion by the F plasmid
M892_RS11815	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
M892_RS11825	COG2205	protein histidine kinase activity
M892_RS11830	COG0745	RESPONSE REGULATOR receiver
M892_RS11860	COG0534	Mate efflux family protein
M892_RS11875	COG3344	reverse transcriptase
M892_RS11890	COG1509	lysine 2,3-aminomutase activity
M892_RS11920	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M892_RS11925	COG1053	succinate dehydrogenase
M892_RS11950	COG4942	peptidase
M892_RS11955	COG1045	serine acetyltransferase
M892_RS11970	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M892_RS11990	COG0471	metal ion transport
M892_RS12010	COG1162	GTPase activity
M892_RS12080	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M892_RS12085	COG0802	atpase or kinase
M892_RS12090	COG0860	N-Acetylmuramoyl-L-alanine amidase
M892_RS12095	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
M892_RS12110	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M892_RS12115	COG0330	HflC and HflK could
M892_RS12120	COG0330	HflC and HflK could
M892_RS12125	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
M892_RS12130	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
M892_RS12135	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
M892_RS12140	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M892_RS12140	COG1017	nitric oxide dioxygenase activity
M892_RS12150	COG0557	exoribonuclease II activity
M892_RS12155	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M892_RS12160	COG0546	phosphoglycolate phosphatase activity
M892_RS12175	COG0512	Glutamine amidotransferase of anthranilate synthase
M892_RS12180	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M892_RS12200	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M892_RS12205	COG3954	Phosphoribulokinase
M892_RS12215	COG0429	hydrolase of the alpha beta-hydrolase fold
M892_RS12225	COG0488	(ABC) transporter
M892_RS12230	COG2249	NAD(P)H dehydrogenase (quinone) activity
M892_RS12245	COG1047	Peptidyl-prolyl cis-trans
M892_RS12250	COG1446	asparaginase
M892_RS12265	COG0545	Peptidyl-prolyl cis-trans isomerase
M892_RS12270	COG2964	Protein conserved in bacteria
M892_RS12275	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
M892_RS12280	COG2923	Belongs to the DsrF TusC family
M892_RS12285	COG2168	tRNA wobble position uridine thiolation
M892_RS12300	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M892_RS12325	COG2906	2 iron, 2 sulfur cluster binding
M892_RS12335	COG0281	malic enzyme
M892_RS12345	COG0626	cystathionine gamma-synthase activity
M892_RS12350	COG0527	aspartate kinase activity
M892_RS12350	COG0460	homoserine dehydrogenase
M892_RS12355	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
M892_RS12365	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
M892_RS12375	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
M892_RS12390	COG0165	Argininosuccinate lyase
M892_RS12390	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
M892_RS12400	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M892_RS12405	COG0678	peroxiredoxin activity
M892_RS12405	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M892_RS12415	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
M892_RS12460	COG0338	D12 class N6 adenine-specific DNA methyltransferase
M892_RS12465	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M892_RS12475	COG2965	DNA replication, synthesis of RNA primer
M892_RS12495	COG0305	Participates in initiation and elongation during chromosome replication
M892_RS12500	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M892_RS12505	COG3385	transposase activity
M892_RS12515	COG0432	Pfam Uncharacterised protein family UPF0047
M892_RS12530	COG0735	belongs to the Fur family
M892_RS12535	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M892_RS12555	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M892_RS12590	COG3335	DDE superfamily endonuclease
M892_RS12605	COG0646	methionine synthase
M892_RS12605	COG1410	methionine synthase
M892_RS12610	COG0527	aspartate kinase activity
M892_RS12615	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M892_RS12625	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M892_RS12640	COG0629	single-stranded DNA binding
M892_RS12650	COG2200	EAL domain
M892_RS12650	COG2199	diguanylate cyclase activity
M892_RS12675	COG3409	Peptidoglycan-binding domain 1 protein
M892_RS12675	COG3267	Type II secretory pathway component ExeA
M892_RS12685	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M892_RS12690	COG1459	type II secretion system
M892_RS12715	COG2165	general secretion pathway protein
M892_RS12735	COG1077	Cell shape determining protein MreB Mrl
M892_RS12740	COG1792	Involved in formation and maintenance of cell shape
M892_RS12745	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
M892_RS12750	COG0424	maF-like protein
M892_RS12760	COG3164	Protein of unknown function
M892_RS12765	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M892_RS12770	COG0312	modulator of DNA gyrase
M892_RS12775	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
M892_RS12790	COG0564	pseudouridine synthase activity
M892_RS12795	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M892_RS12805	COG0312	modulator of DNA gyrase
M892_RS12810	COG3344	reverse transcriptase
M892_RS12815	COG2239	Acts as a magnesium transporter
M892_RS12820	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M892_RS12830	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M892_RS12835	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
M892_RS12850	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
M892_RS12860	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
M892_RS12860	COG0517	IMP dehydrogenase activity
M892_RS12870	COG1127	ABC transporter
M892_RS12875	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
M892_RS12880	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
M892_RS12885	COG2854	intermembrane phospholipid transfer
M892_RS12895	COG5007	Belongs to the BolA IbaG family
M892_RS12905	COG0204	Acyl-transferase
M892_RS12910	COG3344	reverse transcriptase
M892_RS12915	COG0251	oxidation-reduction process
M892_RS12950	COG0456	acetyltransferase
M892_RS12960	COG0525	valine-tRNA ligase activity
M892_RS12965	COG2927	DNA polymerase III (CHI subunit)
M892_RS12975	COG0795	lipopolysaccharide-transporting ATPase activity
M892_RS12980	COG0795	lipopolysaccharide-transporting ATPase activity
M892_RS12990	COG1028	Short-chain dehydrogenase reductase Sdr
M892_RS13010	COG0726	polysaccharide deacetylase
M892_RS13015	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M892_RS13025	COG1447	Phosphotransferase system cellobiose-specific component IIA
M892_RS13030	COG1486	melibiose metabolic process
M892_RS13040	COG1609	Transcriptional regulator
M892_RS13045	COG3437	response regulator, receiver
M892_RS13080	COG1012	belongs to the aldehyde dehydrogenase family
M892_RS13155	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M892_RS13160	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
M892_RS13175	COG0762	integral membrane protein
M892_RS13180	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M892_RS13185	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
M892_RS13200	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
M892_RS13205	COG1678	Uncharacterized ACR, COG1678
M892_RS13210	COG0189	ligase activity
M892_RS13215	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M892_RS13220	COG2356	endonuclease I
M892_RS13240	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
M892_RS13260	COG0191	fructose-bisphosphate aldolase activity
M892_RS13265	COG0668	transmembrane transport
M892_RS13280	COG0583	DNA-binding transcription factor activity
M892_RS13290	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M892_RS13300	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M892_RS13305	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
M892_RS13315	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M892_RS13320	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M892_RS13340	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
M892_RS13350	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
M892_RS13355	COG1595	DNA-templated transcription, initiation
M892_RS13370	COG3086	response to oxidative stress
M892_RS13390	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
M892_RS13395	COG1381	Involved in DNA repair and RecF pathway recombination
M892_RS13400	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
M892_RS13410	COG3385	transposase activity
M892_RS13425	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M892_RS13430	COG3956	TIGRFAM MazG family protein
M892_RS13440	COG0148	phosphopyruvate hydratase activity
M892_RS13450	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
M892_RS13480	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M892_RS13485	COG3385	transposase activity
M892_RS13495	COG1546	Belongs to the CinA family
M892_RS13500	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
M892_RS13515	COG0527	aspartate kinase activity
M892_RS13590	COG3630	sodium ion export across plasma membrane
M892_RS13595	COG0511	ligase activity, forming carbon-carbon bonds
M892_RS13595	COG5016	pyruvate
M892_RS13600	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
M892_RS13610	COG1238	metal cluster binding
M892_RS13615	COG0612	Peptidase, M16
M892_RS13635	COG4536	flavin adenine dinucleotide binding
M892_RS13640	COG4137	Cytochrome C assembly protein
M892_RS13645	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M892_RS13675	COG3547	Transposase (IS116 IS110 IS902 family)
M892_RS13680	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
M892_RS13685	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
M892_RS13690	COG0237	dephospho-CoA kinase activity
M892_RS13700	COG1459	type II secretion system
M892_RS13730	COG2186	Transcriptional regulator
M892_RS13735	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
M892_RS13740	COG0508	dehydrogenase complex catalyzes the overall conversion of
M892_RS13745	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M892_RS13765	COG0288	reversible hydration of carbon dioxide
M892_RS13770	COG0659	secondary active sulfate transmembrane transporter activity
M892_RS13775	COG1131	(ABC) transporter
M892_RS13780	COG0842	Transport permease protein
M892_RS13790	COG1560	Kdo2-lipid A biosynthetic process
M892_RS13805	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M892_RS13815	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M892_RS13830	COG1643	Atp-dependent helicase
M892_RS13835	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M892_RS13840	COG1752	Esterase of the alpha-beta hydrolase superfamily
M892_RS13845	COG1049	propionate catabolic process, 2-methylcitrate cycle
M892_RS13850	COG3547	Transposase (IS116 IS110 IS902 family)
M892_RS13865	COG0004	ammonium transporteR
M892_RS13870	COG1840	ABC-type Fe3 transport system, periplasmic component
M892_RS13880	COG3842	ATPase activity
M892_RS13885	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M892_RS13900	COG2971	BadF BadG BcrA BcrD
M892_RS13910	COG4608	Belongs to the ABC transporter superfamily
M892_RS13915	COG0444	Belongs to the ABC transporter superfamily
M892_RS13920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M892_RS13930	COG0747	negative chemotaxis
M892_RS13935	COG0784	Response regulator, receiver
M892_RS13935	COG2205	protein histidine kinase activity
M892_RS13935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M892_RS13935	COG2198	Histidine kinase
M892_RS13945	COG0628	permease
M892_RS13970	COG0739	heme binding
M892_RS13975	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M892_RS13990	COG2027	D-alanyl-D-alanine carboxypeptidase
M892_RS13995	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
M892_RS14000	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M892_RS14005	COG1534	Rna-binding protein
M892_RS14015	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M892_RS14020	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
M892_RS14035	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M892_RS14055	COG0195	Participates in both transcription termination and antitermination
M892_RS14075	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
M892_RS14095	COG0534	Mate efflux family protein
M892_RS14100	COG0826	peptidase U32
M892_RS14105	COG0826	peptidase U32
M892_RS14115	COG3154	lipid carrier protein
M892_RS14120	COG3153	acetyltransferase
M892_RS14145	COG0084	hydrolase, TatD family'
M892_RS14150	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M892_RS14160	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
M892_RS14170	COG0813	purine-nucleoside phosphorylase activity
M892_RS14180	COG0560	Phosphoserine phosphatase
M892_RS14190	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
M892_RS14195	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M892_RS14225	COG1022	Amp-dependent synthetase and ligase
M892_RS14230	COG0741	lytic transglycosylase activity
M892_RS14235	COG0583	DNA-binding transcription factor activity
M892_RS14250	COG2433	Pfam Transposase IS66
M892_RS14270	COG4964	Belongs to the GSP D family
M892_RS14330	COG0583	DNA-binding transcription factor activity
M892_RS14335	COG0531	amino acid
M892_RS14340	COG2731	YhcH YjgK YiaL family protein
M892_RS14350	COG1609	Transcriptional regulator
M892_RS14355	COG0768	penicillin binding
M892_RS14365	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M892_RS14370	COG3547	Transposase (IS116 IS110 IS902 family)
M892_RS14375	COG1085	galactose-1-phosphate uridylyltransferase
M892_RS14390	COG2017	converts alpha-aldose to the beta-anomer
M892_RS14395	COG1609	Transcriptional regulator
M892_RS14400	COG1263	PTS System
M892_RS14400	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M892_RS14415	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M892_RS14440	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
M892_RS14445	COG1349	DNA-binding transcription factor activity
M892_RS14455	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M892_RS14460	COG2271	Major facilitator Superfamily
M892_RS14465	COG0584	glycerophosphoryl diester phosphodiesterase
M892_RS14470	COG2171	N-acyltransferase activity
M892_RS14490	COG3141	response to X-ray
M892_RS14510	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
M892_RS14515	COG1074	ATP-dependent DNA helicase activity
M892_RS14520	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M892_RS14535	COG3385	transposase activity
M892_RS14545	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
M892_RS14545	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
M892_RS14555	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
M892_RS14560	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
M892_RS14565	COG2166	iron-sulfur cluster assembly
M892_RS14570	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M892_RS14575	COG0693	protein deglycase activity
M892_RS14580	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
M892_RS14600	COG1595	DNA-templated transcription, initiation
M892_RS14630	COG0271	Belongs to the BolA IbaG family
M892_RS14665	COG1477	protein flavinylation
M892_RS14690	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M892_RS14695	COG0514	ATP-dependent DNA helicase (RecQ)
M892_RS14700	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M892_RS14710	COG3385	transposase activity
M892_RS14720	COG0733	neurotransmitter:sodium symporter activity
M892_RS14745	COG1720	tRNA m6t6A37 methyltransferase activity
M892_RS14755	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
M892_RS14785	COG3098	single-species biofilm formation
M892_RS14790	COG0564	pseudouridine synthase activity
M892_RS14805	COG0024	Methionine aminopeptidase
M892_RS14830	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M892_RS14835	COG0575	Belongs to the CDS family
M892_RS14845	COG0750	zinc metalloprotease
M892_RS14855	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
M892_RS14860	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M892_RS14885	COG0587	DNA-directed DNA polymerase activity
M892_RS14905	COG0347	Belongs to the P(II) protein family
M892_RS14920	COG0741	lytic transglycosylase activity
M892_RS14920	COG1388	LysM domain
M892_RS14930	COG2226	methyltransferase
M892_RS14940	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M892_RS14965	COG1960	acyl-CoA dehydrogenase activity
M892_RS14970	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
M892_RS14975	COG0121	glutamine amidotransferase
M892_RS14980	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M892_RS14990	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
M892_RS14995	COG2233	PERMEase
M892_RS15015	COG1393	Belongs to the ArsC family
M892_RS15020	COG4783	chaperone-mediated protein folding
M892_RS15040	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M892_RS15045	COG2716	regulation of RNA biosynthetic process
M892_RS15050	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M892_RS15055	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
M892_RS15075	COG1393	Belongs to the ArsC family
M892_RS15100	COG2837	iron assimilation
M892_RS15110	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M892_RS15115	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M892_RS15125	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M892_RS15130	COG1334	flagellar protein FlaG
M892_RS15135	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
M892_RS15145	COG1516	flagellar protein fliS
M892_RS15165	COG1677	Flagellar hook-basal body complex protein FliE
M892_RS15175	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M892_RS15230	COG1987	bacterial-type flagellum assembly
M892_RS15235	COG1684	flagellar biosynthetic protein fliR
M892_RS15270	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
M892_RS15275	COG0643	Histidine kinase
M892_RS15275	COG0784	Response regulator, receiver
M892_RS15275	COG2198	Histidine kinase
M892_RS15280	COG2201	protein-glutamate methylesterase activity
M892_RS15285	COG1192	Involved in chromosome partitioning
M892_RS15295	COG0835	chemotaxis
M892_RS15305	COG4133	protoheme IX ABC transporter activity
M892_RS15310	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M892_RS15315	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M892_RS15330	COG1138	Cytochrome C-type biogenesis protein
M892_RS15335	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M892_RS15345	COG3088	subunit of a heme lyase
M892_RS15345	COG4235	cytochrome complex assembly
M892_RS15350	COG2853	Lipoprotein
M892_RS15355	COG2067	long-chain fatty acid transport protein
M892_RS15360	COG2067	long-chain fatty acid transport protein
M892_RS15375	COG0183	Belongs to the thiolase family
M892_RS15385	COG3344	reverse transcriptase
M892_RS15395	COG2062	phosphohistidine phosphatase, SixA
M892_RS15405	COG2890	protein-(glutamine-N5) methyltransferase activity
M892_RS15420	COG2860	membrane
M892_RS15425	COG3101	peptidyl-lysine hydroxylation
M892_RS15450	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M892_RS15455	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M892_RS15460	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M892_RS15485	COG0285	dihydrofolate synthase activity
M892_RS15490	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
M892_RS15495	COG1286	toxin biosynthetic process
M892_RS15500	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
M892_RS15510	COG0583	DNA-binding transcription factor activity
M892_RS15515	COG0745	RESPONSE REGULATOR receiver
M892_RS15525	COG2832	Protein of unknown function (DUF454)
M892_RS15535	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M892_RS15545	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
M892_RS15550	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M892_RS15560	COG0251	oxidation-reduction process
M892_RS15570	COG2964	Protein conserved in bacteria
M892_RS15625	COG2261	transglycosylase associated protein
M892_RS15630	COG2985	domain, Protein
M892_RS15635	COG0076	glutamate decarboxylase activity
M892_RS15640	COG0668	transmembrane transport
M892_RS15650	COG0346	lactoylglutathione lyase activity
M892_RS15665	COG1785	Belongs to the alkaline phosphatase family
M892_RS15685	COG2226	methyltransferase
M892_RS15705	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M892_RS15710	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M892_RS15720	COG3139	Protein of unknown function (DUF1315)
M892_RS15725	COG0252	asparaginase activity
M892_RS15730	COG0616	signal peptide processing
M892_RS15735	COG1902	pentaerythritol trinitrate reductase activity
M892_RS15735	COG0446	pyridine nucleotide-disulphide oxidoreductase
M892_RS15740	COG0778	Nitroreductase
M892_RS15745	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M892_RS15765	COG0123	including yeast histone deacetylase and acetoin utilization protein
M892_RS15775	COG4269	membrane
M892_RS15785	COG3385	transposase activity
M892_RS15800	COG3083	sulfuric ester hydrolase activity
M892_RS15815	COG3385	transposase activity
M892_RS15830	COG1757	Na H antiporter
M892_RS15835	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M892_RS15840	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M892_RS15845	COG2095	MarC family integral membrane protein
M892_RS15850	COG1012	belongs to the aldehyde dehydrogenase family
M892_RS15850	COG1454	alcohol dehydrogenase
M892_RS15855	COG3344	reverse transcriptase
M892_RS15860	COG1028	Short-chain dehydrogenase reductase Sdr
M892_RS15875	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
M892_RS15885	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M892_RS15920	COG2433	Pfam Transposase IS66
M892_RS15930	COG3451	type IV secretory pathway VirB4
M892_RS15965	COG2056	Na+-H+ antiporter family
M892_RS15975	COG2885	chlorophyll binding
M892_RS15985	COG0346	lactoylglutathione lyase activity
M892_RS15990	COG3344	reverse transcriptase
M892_RS15995	COG0840	transmembrane signaling receptor activity
M892_RS16015	COG2433	Pfam Transposase IS66
M892_RS16050	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M892_RS16055	COG4660	Part of a membrane complex involved in electron transport
M892_RS16060	COG4659	FMN binding
M892_RS16065	COG4658	electron transport chain
M892_RS16070	COG4656	Part of a membrane complex involved in electron transport
M892_RS16085	COG1882	Formate acetyltransferase
M892_RS16095	COG0556	nucleotide-excision repair
M892_RS16120	COG2433	Pfam Transposase IS66
M892_RS16125	COG0391	Required for morphogenesis under gluconeogenic growth conditions
M892_RS16130	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M892_RS16135	COG0521	Mo-molybdopterin cofactor biosynthetic process
M892_RS16145	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
M892_RS16150	COG0314	molybdopterin synthase activity
M892_RS16160	COG0601	transmembrane transport
M892_RS16165	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M892_RS16170	COG0444	Belongs to the ABC transporter superfamily
M892_RS16180	COG0435	Glutathione S-transferase
M892_RS16185	COG0857	belongs to the CobB CobQ family
M892_RS16185	COG0280	phosphate acetyltransferase
M892_RS16205	COG4120	Belongs to the binding-protein-dependent transport system permease family
M892_RS16210	COG1122	ATPase activity
M892_RS16225	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M892_RS16230	COG0653	protein targeting
M892_RS16235	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
M892_RS16245	COG2186	Transcriptional regulator
M892_RS16275	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
M892_RS16280	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M892_RS16285	COG0659	secondary active sulfate transmembrane transporter activity
M892_RS16295	COG1530	ribonuclease E activity
M892_RS16300	COG0564	pseudouridine synthase activity
M892_RS16310	COG0424	maF-like protein
M892_RS16315	COG1399	metal-binding, possibly nucleic acid-binding protein
M892_RS16330	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M892_RS16360	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M892_RS16375	COG0084	hydrolase, TatD family'
M892_RS16380	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M892_RS16380	COG1263	PTS System
M892_RS16390	COG3385	transposase activity
M892_RS16395	COG0733	neurotransmitter:sodium symporter activity
M892_RS16415	COG4667	esterase of the alpha-beta hydrolase superfamily
M892_RS16480	COG2272	Belongs to the type-B carboxylesterase lipase family
M892_RS16510	COG2433	Pfam Transposase IS66
M892_RS16525	COG1940	carbohydrate kinase activity
M892_RS16530	COG0784	Response regulator, receiver
M892_RS16530	COG0835	chemotaxis
M892_RS16550	COG1028	Short-chain dehydrogenase reductase Sdr
M892_RS16555	COG0616	signal peptide processing
M892_RS16565	COG0539	negative regulation of cytoplasmic translation
M892_RS16575	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
M892_RS16580	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
M892_RS16590	COG4166	transmembrane transport
M892_RS16605	COG3009	Protein conserved in bacteria
M892_RS16610	COG3008	intermembrane lipid transfer
M892_RS16610	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
M892_RS16615	COG2995	paraquat-inducible protein a
M892_RS16630	COG4232	protein-disulfide reductase activity
M892_RS16645	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M892_RS16670	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M892_RS16690	COG0577	efflux transmembrane transporter activity
M892_RS16690	COG1136	(ABC) transporter
M892_RS16705	COG2176	DNA-directed DNA polymerase activity
M892_RS16775	COG3547	Transposase (IS116 IS110 IS902 family)
M892_RS16820	COG3547	Transposase (IS116 IS110 IS902 family)
M892_RS16850	COG3850	Histidine kinase
M892_RS16850	COG5002	protein histidine kinase activity
M892_RS16855	COG0745	RESPONSE REGULATOR receiver
M892_RS16860	COG0463	Glycosyl transferase, family 2
M892_RS16865	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
M892_RS16875	COG0840	transmembrane signaling receptor activity
M892_RS16880	COG2175	clavaminate synthase activity
M892_RS16885	COG2964	Protein conserved in bacteria
M892_RS16890	COG0251	oxidation-reduction process
M892_RS16900	COG0446	pyridine nucleotide-disulphide oxidoreductase
M892_RS16920	COG1032	radical SAM domain protein
M892_RS16925	COG5001	Diguanylate cyclase
M892_RS16925	COG1716	ATPase activity
M892_RS16955	COG2350	Protein conserved in bacteria
M892_RS16985	COG1301	dicarboxylic acid transport
M892_RS16990	COG0159	tryptophan synthase activity
M892_RS17000	COG0135	phosphoribosylanthranilate isomerase activity
M892_RS17000	COG0134	indole-3-glycerol-phosphate synthase activity
M892_RS17010	COG0512	Glutamine amidotransferase of anthranilate synthase
M892_RS17015	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M892_RS17025	COG0613	PHP domain protein
M892_RS17030	COG0009	L-threonylcarbamoyladenylate synthase
M892_RS17040	COG1187	pseudouridine synthase activity
M892_RS17060	COG0417	DNA replication proofreading
M892_RS17065	COG2197	response regulator
M892_RS17100	COG0019	diaminopimelate decarboxylase activity
M892_RS17115	COG1546	Belongs to the CinA family
M892_RS17115	COG1058	Belongs to the CinA family
M892_RS17125	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M892_RS17130	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M892_RS17155	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
M892_RS17170	COG3301	Polysulphide reductase, NrfD
M892_RS17175	COG1138	Cytochrome C-type biogenesis protein
M892_RS17185	COG4235	cytochrome complex assembly
M892_RS17185	COG3088	subunit of a heme lyase
M892_RS17220	COG2989	Protein conserved in bacteria
M892_RS17225	COG3108	Peptidase M15
M892_RS17230	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M892_RS17295	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
M892_RS17335	COG0733	neurotransmitter:sodium symporter activity
M892_RS17505	COG1061	Type III restriction enzyme res subunit
M892_RS18065	COG3335	DDE superfamily endonuclease
M892_RS18115	COG0861	Integral membrane protein TerC family
M892_RS18165	COG1132	(ABC) transporter
M892_RS18170	COG1132	(ABC) transporter
M892_RS18495	COG0215	cysteine-tRNA ligase activity
M892_RS18500	COG0215	cysteine-tRNA ligase activity
M892_RS18520	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
M892_RS18625	COG3290	protein histidine kinase activity
M892_RS19490	COG4133	protoheme IX ABC transporter activity
M892_RS19750	COG2205	protein histidine kinase activity
M892_RS19750	COG3850	Histidine kinase
M892_RS19750	COG3437	response regulator, receiver
M892_RS19750	COG4999	Histidine kinase
M892_RS19835	COG0519	Catalyzes the synthesis of GMP from XMP
M892_RS20245	COG1132	(ABC) transporter
M892_RS20625	COG2433	Pfam Transposase IS66
M892_RS20895	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M892_RS21310	COG0131	Imidazoleglycerol-phosphate dehydratase
M892_RS21310	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
M892_RS21345	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M892_RS21370	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M892_RS21835	COG4791	protein targeting
M892_RS22285	COG0823	Involved in the tonB-independent uptake of proteins
M892_RS22435	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
M892_RS22450	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
M892_RS22520	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M892_RS22525	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M892_RS22755	COG1132	(ABC) transporter
M892_RS23030	COG2433	Pfam Transposase IS66
M892_RS23290	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M892_RS23290	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
M892_RS23295	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M892_RS23370	COG0318	PFAM AMP-dependent synthetase and ligase
M892_RS23380	COG2267	carboxylic ester hydrolase activity
M892_RS23400	COG1199	ATP-dependent helicase activity
M892_RS23505	COG0567	Dehydrogenase, E1 component
M892_RS23540	COG3547	Transposase (IS116 IS110 IS902 family)
M892_RS23590	COG1263	PTS System
M892_RS23590	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M892_RS23690	COG0330	HflC and HflK could
M892_RS23965	COG1187	pseudouridine synthase activity
M892_RS24115	COG0768	penicillin binding
M892_RS24165	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M892_RS24185	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M892_RS24185	COG1263	PTS System
M892_RS24455	COG0047	phosphoribosylformylglycinamidine synthase activity
M892_RS24455	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M892_RS24670	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
M892_RS25290	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
M892_RS25340	COG4974	Belongs to the 'phage' integrase family
M892_RS25390	COG1115	amino acid carrier protein
M892_RS25510	COG5002	protein histidine kinase activity
M892_RS25510	COG2198	Histidine kinase
M892_RS25510	COG0784	Response regulator, receiver
M892_RS25515	COG5002	protein histidine kinase activity
M892_RS25515	COG0784	Response regulator, receiver
M892_RS25515	COG2198	Histidine kinase
M892_RS25545	COG0070	glutamate synthase
M892_RS25545	COG0069	glutamate synthase activity
M892_RS25545	COG0067	glutamate synthase
M892_RS25615	COG0069	glutamate synthase activity
M892_RS25615	COG0067	glutamate synthase
M892_RS25615	COG0070	glutamate synthase
M892_RS25920	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
M892_RS25955	COG3025	triphosphatase activity
M892_RS26235	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
M892_RS26420	COG0513	Belongs to the DEAD box helicase family
M892_RS26515	COG1609	Transcriptional regulator
M892_RS26720	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M892_RS26855	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M892_RS27265	COG1322	Protein conserved in bacteria
M892_RS27375	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
M892_RS27695	COG3344	reverse transcriptase
M892_RS27835	COG4372	Transposase
M892_RS27870	COG3547	Transposase (IS116 IS110 IS902 family)
M892_RS27875	COG3547	Transposase (IS116 IS110 IS902 family)