locus-tag	class	description
DSB67_RS00010	COG0592	DNA-directed DNA polymerase activity
DSB67_RS00020	COG0187	DNA topoisomerase II activity
DSB67_RS00025	COG0071	Belongs to the small heat shock protein (HSP20) family
DSB67_RS00030	COG3977	Valine--pyruvate aminotransferase
DSB67_RS00045	COG2119	membrane
DSB67_RS00070	COG0604	alcohol dehydrogenase
DSB67_RS00075	COG0183	Belongs to the thiolase family
DSB67_RS00085	COG1739	Uncharacterized protein family UPF0029
DSB67_RS00090	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DSB67_RS00140	COG0583	DNA-binding transcription factor activity
DSB67_RS00145	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DSB67_RS00150	COG2960	long-chain fatty acid transporting porin activity
DSB67_RS00160	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DSB67_RS00165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DSB67_RS00210	COG0546	phosphoglycolate phosphatase activity
DSB67_RS00225	COG4166	transmembrane transport
DSB67_RS00230	COG0601	transmembrane transport
DSB67_RS00235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DSB67_RS00280	COG0800	Aldolase
DSB67_RS00285	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DSB67_RS00295	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
DSB67_RS00310	COG1522	sequence-specific DNA binding
DSB67_RS00315	COG5001	Diguanylate cyclase
DSB67_RS00315	COG5002	protein histidine kinase activity
DSB67_RS00335	COG0589	response to stress
DSB67_RS00340	COG1528	Iron-storage protein
DSB67_RS00350	COG2081	HI0933 family
DSB67_RS00370	COG1910	domain protein
DSB67_RS00385	COG1322	Protein conserved in bacteria
DSB67_RS00395	COG3165	ubiquinone biosynthetic process from chorismate
DSB67_RS00410	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DSB67_RS00415	COG0805	protein transport
DSB67_RS00420	COG0084	hydrolase, TatD family'
DSB67_RS00440	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DSB67_RS00440	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DSB67_RS00450	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DSB67_RS00485	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DSB67_RS00495	COG2204	response regulator
DSB67_RS00500	COG3852	Histidine kinase
DSB67_RS00510	COG0174	glutamine synthetase
DSB67_RS00520	COG1217	gtp-binding protein TYPA
DSB67_RS00540	COG1490	D-aminoacyl-tRNA deacylase activity
DSB67_RS00545	COG0456	acetyltransferase
DSB67_RS00565	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DSB67_RS00570	COG3031	protein transport across the cell outer membrane
DSB67_RS00580	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DSB67_RS00585	COG1459	type II secretion system
DSB67_RS00590	COG2165	general secretion pathway protein
DSB67_RS00595	COG2165	general secretion pathway protein
DSB67_RS00600	COG2165	general secretion pathway protein
DSB67_RS00605	COG4795	General secretion pathway protein
DSB67_RS00610	COG3156	type II secretion system protein K
DSB67_RS00615	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
DSB67_RS00620	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
DSB67_RS00630	COG1218	3'(2'),5'-bisphosphate nucleotidase
DSB67_RS00635	COG0494	nUDIX hydrolase
DSB67_RS00645	COG1040	competence protein
DSB67_RS00660	COG2183	response to ionizing radiation
DSB67_RS00695	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DSB67_RS00710	COG0464	growth
DSB67_RS00745	COG2233	PERMEase
DSB67_RS00750	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DSB67_RS00755	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DSB67_RS00760	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DSB67_RS00765	COG1758	RNA polymerase activity
DSB67_RS00770	COG0194	GDP metabolic process
DSB67_RS00785	COG0848	biopolymer transport protein
DSB67_RS00790	COG0811	peptide transport
DSB67_RS00810	COG4174	ABC transporter (Permease)
DSB67_RS00815	COG4239	(ABC) transporter, permease
DSB67_RS00820	COG0747	negative chemotaxis
DSB67_RS00825	COG0444	Belongs to the ABC transporter superfamily
DSB67_RS00830	COG4608	Belongs to the ABC transporter superfamily
DSB67_RS00845	COG2246	polysaccharide biosynthetic process
DSB67_RS00855	COG1561	YicC-like family, N-terminal region
DSB67_RS00860	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DSB67_RS00865	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DSB67_RS00870	COG1560	Kdo2-lipid A biosynthetic process
DSB67_RS00880	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DSB67_RS00915	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DSB67_RS00930	COG0463	Glycosyl transferase, family 2
DSB67_RS00935	COG0859	PFAM glycosyl transferase family 9
DSB67_RS00940	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DSB67_RS00945	COG3642	lipopolysaccharide core region biosynthetic process
DSB67_RS00955	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
DSB67_RS00995	COG1519	Transferase
DSB67_RS01000	COG0859	PFAM glycosyl transferase family 9
DSB67_RS01010	COG1560	Kdo2-lipid A biosynthetic process
DSB67_RS01020	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DSB67_RS01055	COG0463	Glycosyl transferase, family 2
DSB67_RS01070	COG0438	transferase activity, transferring glycosyl groups
DSB67_RS01070	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DSB67_RS01085	COG0438	transferase activity, transferring glycosyl groups
DSB67_RS01105	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DSB67_RS01110	COG1459	type II secretion system
DSB67_RS01115	COG2165	general secretion pathway protein
DSB67_RS01165	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DSB67_RS01200	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DSB67_RS01205	COG0110	maltose O-acetyltransferase activity
DSB67_RS01210	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DSB67_RS01230	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DSB67_RS01235	COG0149	triose-phosphate isomerase activity
DSB67_RS01265	COG1494	fructose-1,6-bisphosphatase
DSB67_RS01280	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DSB67_RS01285	COG1575	Belongs to the MenA family. Type 1 subfamily
DSB67_RS01305	COG1609	Transcriptional regulator
DSB67_RS01310	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DSB67_RS01330	COG0088	Forms part of the polypeptide exit tunnel
DSB67_RS01415	COG1841	ribosomal large subunit assembly
DSB67_RS01425	COG0201	protein transport
DSB67_RS01430	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DSB67_RS01435	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DSB67_RS01440	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DSB67_RS01450	COG0202	RNA polymerase activity
DSB67_RS01455	COG0203	ribosomal protein L17
DSB67_RS01465	COG0545	Peptidyl-prolyl cis-trans isomerase
DSB67_RS01480	COG2153	protein acetylation
DSB67_RS01485	COG0513	Belongs to the DEAD box helicase family
DSB67_RS01495	COG0737	Belongs to the 5'-nucleotidase family
DSB67_RS01500	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DSB67_RS01500	COG1648	precorrin-2 dehydrogenase activity
DSB67_RS01515	COG3273	potassium ion transport
DSB67_RS01515	COG0471	metal ion transport
DSB67_RS01520	COG0529	Catalyzes the synthesis of activated sulfate
DSB67_RS01540	COG1136	(ABC) transporter
DSB67_RS01555	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
DSB67_RS01565	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DSB67_RS01580	COG2105	PFAM AIG2 family protein
DSB67_RS01590	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DSB67_RS01600	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DSB67_RS01605	COG0163	prenyltransferase activity
DSB67_RS01610	COG4143	(ABC) transporter
DSB67_RS01615	COG1178	ABC-type Fe3 transport system permease component
DSB67_RS01620	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
DSB67_RS01635	COG2358	TRAP transporter, solute receptor (TAXI family
DSB67_RS01655	COG0142	geranyltranstransferase activity
DSB67_RS01660	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DSB67_RS01675	COG2966	Psort location CytoplasmicMembrane, score
DSB67_RS01680	COG3610	response to peptide
DSB67_RS01705	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DSB67_RS01710	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DSB67_RS01715	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
DSB67_RS01720	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
DSB67_RS01740	COG0473	3-isopropylmalate dehydrogenase activity
DSB67_RS01745	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DSB67_RS01770	COG0583	DNA-binding transcription factor activity
DSB67_RS01775	COG1022	Amp-dependent synthetase and ligase
DSB67_RS01780	COG0028	Belongs to the TPP enzyme family
DSB67_RS01785	COG0440	acetolactate synthase activity
DSB67_RS01800	COG0469	pyruvate kinase activity
DSB67_RS01805	COG1349	DNA-binding transcription factor activity
DSB67_RS01810	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DSB67_RS01855	COG0358	DNA primase activity
DSB67_RS01860	COG1610	YqeY-like protein
DSB67_RS01865	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DSB67_RS01870	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DSB67_RS01875	COG0596	Alpha beta hydrolase
DSB67_RS01885	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DSB67_RS01890	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DSB67_RS01905	COG3267	Type II secretory pathway component ExeA
DSB67_RS01905	COG3409	Peptidoglycan-binding domain 1 protein
DSB67_RS01915	COG4991	sh3 domain protein
DSB67_RS01920	COG0306	phosphate transporter
DSB67_RS01925	COG1392	Phosphate transport regulator
DSB67_RS01930	COG3025	triphosphatase activity
DSB67_RS01935	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DSB67_RS01945	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
DSB67_RS01955	COG1538	Outer membrane efflux protein
DSB67_RS01960	COG0494	nUDIX hydrolase
DSB67_RS01965	COG3151	Protein conserved in bacteria
DSB67_RS01975	COG3150	esterase
DSB67_RS01985	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DSB67_RS01990	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DSB67_RS01995	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DSB67_RS02000	COG3105	Protein conserved in bacteria
DSB67_RS02010	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
DSB67_RS02030	COG0723	plastoquinol--plastocyanin reductase activity
DSB67_RS02035	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DSB67_RS02040	COG2857	Cytochrome c1
DSB67_RS02045	COG0625	glutathione transferase activity
DSB67_RS02050	COG2969	positive regulation of protein catabolic process
DSB67_RS02055	COG2823	Periplasmic or secreted lipoprotein
DSB67_RS02060	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
DSB67_RS02075	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DSB67_RS02095	COG3116	cell division
DSB67_RS02100	COG0768	penicillin binding
DSB67_RS02105	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DSB67_RS02110	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DSB67_RS02125	COG0772	Belongs to the SEDS family
DSB67_RS02140	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DSB67_RS02145	COG0849	cell division
DSB67_RS02150	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DSB67_RS02170	COG0494	nUDIX hydrolase
DSB67_RS02180	COG0505	Belongs to the CarA family
DSB67_RS02185	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DSB67_RS02190	COG0730	response to heat
DSB67_RS02195	COG0583	DNA-binding transcription factor activity
DSB67_RS02200	COG2860	membrane
DSB67_RS02225	COG0493	'glutamate synthase
DSB67_RS02230	COG0070	glutamate synthase
DSB67_RS02230	COG0069	glutamate synthase activity
DSB67_RS02230	COG0067	glutamate synthase
DSB67_RS02240	COG0067	glutamate synthase
DSB67_RS02240	COG0069	glutamate synthase activity
DSB67_RS02240	COG0070	glutamate synthase
DSB67_RS02245	COG1242	4 iron, 4 sulfur cluster binding
DSB67_RS02250	COG5001	Diguanylate cyclase
DSB67_RS02250	COG3706	GGDEF domain
DSB67_RS02250	COG2203	Gaf domain
DSB67_RS02250	COG4251	negative regulation of phosphorylation
DSB67_RS02260	COG5002	protein histidine kinase activity
DSB67_RS02260	COG2198	Histidine kinase
DSB67_RS02260	COG0784	Response regulator, receiver
DSB67_RS02270	COG0745	RESPONSE REGULATOR receiver
DSB67_RS02285	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DSB67_RS02300	COG0083	homoserine kinase activity
DSB67_RS02305	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DSB67_RS02335	COG1115	amino acid carrier protein
DSB67_RS02340	COG3022	response to hydroperoxide
DSB67_RS02350	COG0513	Belongs to the DEAD box helicase family
DSB67_RS02365	COG0716	FMN binding
DSB67_RS02370	COG4974	Belongs to the 'phage' integrase family
DSB67_RS02375	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DSB67_RS02380	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DSB67_RS02405	COG0667	Aldo Keto reductase
DSB67_RS02430	COG0730	response to heat
DSB67_RS02445	COG1283	sodium-dependent phosphate transmembrane transporter activity
DSB67_RS02450	COG0583	DNA-binding transcription factor activity
DSB67_RS02455	COG0640	Transcriptional regulator
DSB67_RS02460	COG0268	Binds directly to 16S ribosomal RNA
DSB67_RS02465	COG0728	peptidoglycan biosynthetic process
DSB67_RS02470	COG0196	riboflavin kinase activity
DSB67_RS02485	COG1047	Peptidyl-prolyl cis-trans
DSB67_RS02490	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DSB67_RS02495	COG3279	Response regulator of the LytR AlgR family
DSB67_RS02500	COG3275	phosphorelay sensor kinase activity
DSB67_RS02505	COG1966	Carbon starvation protein
DSB67_RS02525	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
DSB67_RS02535	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DSB67_RS02540	COG1605	Chorismate mutase
DSB67_RS02540	COG0287	Prephenate dehydrogenase
DSB67_RS02545	COG0739	heme binding
DSB67_RS02555	COG0488	(ABC) transporter
DSB67_RS02570	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
DSB67_RS02575	COG0077	Prephenate dehydratase
DSB67_RS02575	COG1605	Chorismate mutase
DSB67_RS02580	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DSB67_RS02585	COG0741	lytic transglycosylase activity
DSB67_RS02590	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DSB67_RS02595	COG0564	pseudouridine synthase activity
DSB67_RS02600	COG1496	oxidoreductase activity
DSB67_RS02605	COG0542	response to heat
DSB67_RS02665	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DSB67_RS02670	COG0826	peptidase U32
DSB67_RS02680	COG0745	RESPONSE REGULATOR receiver
DSB67_RS02685	COG5002	protein histidine kinase activity
DSB67_RS02695	COG0248	Ppx GppA phosphatase
DSB67_RS02700	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DSB67_RS02705	COG0573	inorganic phosphate transmembrane transporter activity
DSB67_RS02710	COG0581	inorganic phosphate transmembrane transporter activity
DSB67_RS02715	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DSB67_RS02720	COG0704	Plays a role in the regulation of phosphate uptake
DSB67_RS02735	COG0450	alkyl hydroperoxide reductase
DSB67_RS02740	COG0583	DNA-binding transcription factor activity
DSB67_RS02745	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DSB67_RS02755	COG0517	IMP dehydrogenase activity
DSB67_RS02775	COG1862	Preprotein translocase
DSB67_RS02780	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DSB67_RS02785	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DSB67_RS02790	COG0483	inositol monophosphate 1-phosphatase activity
DSB67_RS02795	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
DSB67_RS02810	COG0822	iron-sulfur transferase activity
DSB67_RS02815	COG0316	Belongs to the HesB IscA family
DSB67_RS02830	COG0633	Ferredoxin
DSB67_RS02835	COG2975	iron-sulfur cluster assembly
DSB67_RS02870	COG2976	Protein conserved in bacteria
DSB67_RS02875	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DSB67_RS02890	COG2203	Gaf domain
DSB67_RS02890	COG2199	diguanylate cyclase activity
DSB67_RS02905	COG0517	IMP dehydrogenase activity
DSB67_RS02905	COG0516	GMP reductase activity
DSB67_RS02925	COG1584	GPR1 FUN34 yaaH family protein
DSB67_RS02930	COG1115	amino acid carrier protein
DSB67_RS02940	COG0583	DNA-binding transcription factor activity
DSB67_RS02945	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DSB67_RS02950	COG0668	transmembrane transport
DSB67_RS02965	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DSB67_RS02990	COG0583	DNA-binding transcription factor activity
DSB67_RS03005	COG2867	negative regulation of translational initiation
DSB67_RS03010	COG2914	Belongs to the UPF0125 (RnfH) family
DSB67_RS03015	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DSB67_RS03020	COG0456	acetyltransferase
DSB67_RS03025	COG0497	DNA recombination
DSB67_RS03040	COG1301	dicarboxylic acid transport
DSB67_RS03045	COG0443	Heat shock 70 kDa protein
DSB67_RS03080	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
DSB67_RS03090	COG0590	tRNA wobble adenosine to inosine editing
DSB67_RS03105	COG0047	phosphoribosylformylglycinamidine synthase activity
DSB67_RS03105	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DSB67_RS03135	COG2195	Cleaves the N-terminal amino acid of tripeptides
DSB67_RS03140	COG2252	PERMEase
DSB67_RS03150	COG1073	alpha beta
DSB67_RS03165	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DSB67_RS03170	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DSB67_RS03175	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DSB67_RS03175	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DSB67_RS03200	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DSB67_RS03205	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DSB67_RS03215	COG0142	geranyltranstransferase activity
DSB67_RS03225	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DSB67_RS03240	COG0583	DNA-binding transcription factor activity
DSB67_RS03250	COG2363	Small membrane protein
DSB67_RS03270	COG1611	Belongs to the LOG family
DSB67_RS03295	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
DSB67_RS03310	COG1464	Belongs to the NlpA lipoprotein family
DSB67_RS03315	COG2011	ABC-type metal ion transport system permease component
DSB67_RS03320	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DSB67_RS03325	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
DSB67_RS03335	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DSB67_RS03335	COG1263	PTS System
DSB67_RS03340	COG0366	Alpha amylase catalytic
DSB67_RS03345	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DSB67_RS03350	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DSB67_RS03370	COG1686	Belongs to the peptidase S11 family
DSB67_RS03375	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DSB67_RS03380	COG0772	Belongs to the SEDS family
DSB67_RS03385	COG0768	penicillin binding
DSB67_RS03395	COG0799	negative regulation of ribosome biogenesis
DSB67_RS03400	COG1466	dna polymerase III delta subunit
DSB67_RS03405	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
DSB67_RS03415	COG2888	peptidyl-tyrosine sulfation
DSB67_RS03420	COG0815	Transfers the fatty acyl group on membrane lipoproteins
DSB67_RS03425	COG4535	Mg2 and Co2 transporter CorC
DSB67_RS03435	COG1702	phosphate starvation-inducible protein PhoH
DSB67_RS03450	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DSB67_RS03575	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DSB67_RS03600	COG2890	protein-(glutamine-N5) methyltransferase activity
DSB67_RS03605	COG3094	Invasion gene expression up-regulator, SirB
DSB67_RS03610	COG2912	Transglutaminase-like superfamily
DSB67_RS03620	COG0737	Belongs to the 5'-nucleotidase family
DSB67_RS03625	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DSB67_RS03630	COG1187	pseudouridine synthase activity
DSB67_RS03635	COG2840	Smr protein MutS2
DSB67_RS03680	COG2608	mercury ion transmembrane transporter activity
DSB67_RS03680	COG2217	Heavy metal translocating P-type atpase
DSB67_RS03690	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
DSB67_RS03750	COG0835	chemotaxis
DSB67_RS03750	COG0784	Response regulator, receiver
DSB67_RS03755	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DSB67_RS03760	COG1815	bacterial-type flagellum-dependent cell motility
DSB67_RS03765	COG1558	bacterial-type flagellum-dependent cell motility
DSB67_RS03775	COG1749	Flagellar hook protein flgE
DSB67_RS03780	COG4787	bacterial-type flagellum-dependent cell motility
DSB67_RS03790	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
DSB67_RS03795	COG1706	bacterial-type flagellum-dependent cell motility
DSB67_RS03800	COG1705	Flagellar rod assembly protein muramidase FlgJ
DSB67_RS03800	COG3951	Flagellar rod assembly protein muramidase FlgJ
DSB67_RS03815	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DSB67_RS03820	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DSB67_RS03825	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DSB67_RS03830	COG2190	(PTS) system
DSB67_RS03835	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DSB67_RS03840	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DSB67_RS03850	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DSB67_RS03855	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
DSB67_RS03890	COG0330	HflC and HflK could
DSB67_RS03895	COG3118	belongs to the thioredoxin family
DSB67_RS03905	COG0300	oxidoreductase activity
DSB67_RS03910	COG1090	epimerase
DSB67_RS03920	COG0622	Phosphoesterase
DSB67_RS03940	COG3710	Transcriptional regulator
DSB67_RS03955	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DSB67_RS03960	COG3104	oligopeptide transport
DSB67_RS03970	COG0367	asparagine synthase
DSB67_RS03975	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DSB67_RS03975	COG4651	solute:proton antiporter activity
DSB67_RS03980	COG1940	carbohydrate kinase activity
DSB67_RS03980	COG1846	Transcriptional regulator
DSB67_RS03985	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DSB67_RS03995	COG2190	(PTS) system
DSB67_RS03995	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DSB67_RS03995	COG1263	PTS System
DSB67_RS04010	COG0735	belongs to the Fur family
DSB67_RS04030	COG0596	Alpha beta hydrolase
DSB67_RS04035	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
DSB67_RS04040	COG0033	Phosphoglucomutase
DSB67_RS04055	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DSB67_RS04070	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
DSB67_RS04075	COG1053	succinate dehydrogenase
DSB67_RS04085	COG0567	Dehydrogenase, E1 component
DSB67_RS04090	COG0508	dehydrogenase complex catalyzes the overall conversion of
DSB67_RS04105	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DSB67_RS04110	COG1121	(ABC) transporter
DSB67_RS04115	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
DSB67_RS04120	COG4977	sequence-specific DNA binding
DSB67_RS04125	COG1918	ferrous iron import across plasma membrane
DSB67_RS04160	COG3102	Protein conserved in bacteria
DSB67_RS04175	COG0788	formyltetrahydrofolate deformylase activity
DSB67_RS04180	COG1199	ATP-dependent helicase activity
DSB67_RS04185	COG1214	PFAM Peptidase M22, glycoprotease
DSB67_RS04195	COG3065	identical protein binding
DSB67_RS04200	COG2267	carboxylic ester hydrolase activity
DSB67_RS04205	COG0318	PFAM AMP-dependent synthetase and ligase
DSB67_RS04210	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
DSB67_RS04215	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
DSB67_RS04220	COG2894	cell division
DSB67_RS04235	COG2951	lytic endotransglycosylase activity
DSB67_RS04245	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DSB67_RS04250	COG2852	Protein conserved in bacteria
DSB67_RS04305	COG1028	Short-chain dehydrogenase reductase Sdr
DSB67_RS04315	COG1169	isochorismate synthase
DSB67_RS04320	COG1021	2,3-dihydroxybenzoate-AMP ligase
DSB67_RS04325	COG3433	isochorismatase activity
DSB67_RS04325	COG1535	isochorismatase
DSB67_RS04330	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DSB67_RS04330	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DSB67_RS04340	COG2977	Belongs to the P-Pant transferase superfamily
DSB67_RS04345	COG4771	TonB-dependent receptor
DSB67_RS04355	COG0513	Belongs to the DEAD box helicase family
DSB67_RS04360	COG0569	domain protein
DSB67_RS04365	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DSB67_RS04385	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DSB67_RS04390	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
DSB67_RS04395	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DSB67_RS04430	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DSB67_RS04435	COG0776	regulation of translation
DSB67_RS04440	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DSB67_RS04445	COG1555	photosystem II stabilization
DSB67_RS04465	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
DSB67_RS04470	COG0436	Aminotransferase
DSB67_RS04475	COG1169	isochorismate synthase
DSB67_RS04485	COG0596	Alpha beta hydrolase
DSB67_RS04490	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
DSB67_RS04505	COG2190	(PTS) system
DSB67_RS04505	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DSB67_RS04505	COG1263	PTS System
DSB67_RS04510	COG0583	DNA-binding transcription factor activity
DSB67_RS04515	COG2855	membrane
DSB67_RS04580	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DSB67_RS04600	COG1522	sequence-specific DNA binding
DSB67_RS04605	COG1946	Acyl-CoA thioesterase
DSB67_RS04610	COG3126	Type III secretion system lipoprotein chaperone (YscW)
DSB67_RS04625	COG3706	GGDEF domain
DSB67_RS04635	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DSB67_RS04640	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
DSB67_RS04645	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
DSB67_RS04650	COG0517	IMP dehydrogenase activity
DSB67_RS04650	COG0516	GMP reductase activity
DSB67_RS04660	COG2217	Heavy metal translocating P-type atpase
DSB67_RS04680	COG0537	adenosine 5'-monophosphoramidase activity
DSB67_RS04710	COG1252	NADH dehydrogenase
DSB67_RS04725	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DSB67_RS04735	COG4591	ABC-type transport system involved in lipoprotein release permease component
DSB67_RS04740	COG1136	(ABC) transporter
DSB67_RS04745	COG4591	ABC-type transport system involved in lipoprotein release permease component
DSB67_RS04755	COG0658	competence protein
DSB67_RS04755	COG2333	competence protein COMEC
DSB67_RS04760	COG1132	(ABC) transporter
DSB67_RS04780	COG2719	SpoVR family
DSB67_RS04785	COG2718	Belongs to the UPF0229 family
DSB67_RS04790	COG2766	serine protein kinase
DSB67_RS04810	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DSB67_RS04820	COG1882	Formate acetyltransferase
DSB67_RS04855	COG0708	Exodeoxyribonuclease III
DSB67_RS04865	COG3923	Primosomal replication protein n
DSB67_RS04870	COG0730	response to heat
DSB67_RS04875	COG1199	ATP-dependent helicase activity
DSB67_RS04885	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
DSB67_RS04890	COG1187	pseudouridine synthase activity
DSB67_RS04900	COG1278	Cold shock
DSB67_RS04910	COG0542	response to heat
DSB67_RS04915	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DSB67_RS04945	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DSB67_RS04950	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DSB67_RS04955	COG0297	glycogen (starch) synthase activity
DSB67_RS04975	COG3070	regulator of competence-specific genes
DSB67_RS04990	COG0745	RESPONSE REGULATOR receiver
DSB67_RS04995	COG1434	Gram-negative-bacterium-type cell wall biogenesis
DSB67_RS05000	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DSB67_RS05010	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
DSB67_RS05015	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
DSB67_RS05035	COG4067	protein conserved in archaea
DSB67_RS05035	COG0189	ligase activity
DSB67_RS05050	COG1801	Protein of unknown function DUF72
DSB67_RS05065	COG0840	transmembrane signaling receptor activity
DSB67_RS05070	COG0632	four-way junction helicase activity
DSB67_RS05080	COG1271	oxidase subunit
DSB67_RS05085	COG1294	oxidase, subunit
DSB67_RS05090	COG4890	Cyd operon protein YbgT
DSB67_RS05100	COG0824	Thioesterase
DSB67_RS05105	COG0811	peptide transport
DSB67_RS05120	COG0823	Involved in the tonB-independent uptake of proteins
DSB67_RS05125	COG2885	chlorophyll binding
DSB67_RS05145	COG3766	membrane
DSB67_RS05155	COG0754	glutathionylspermidine amidase activity
DSB67_RS05165	COG0784	Response regulator, receiver
DSB67_RS05165	COG2205	protein histidine kinase activity
DSB67_RS05230	COG0456	acetyltransferase
DSB67_RS05330	COG4669	(LipO)protein
DSB67_RS05360	COG3177	Filamentation induced by cAMP protein fic
DSB67_RS05370	COG0583	DNA-binding transcription factor activity
DSB67_RS05375	COG4792	protein secretion
DSB67_RS05380	COG4791	protein targeting
DSB67_RS05385	COG4794	Type iii secretion
DSB67_RS05390	COG4790	Type iii secretion
DSB67_RS05460	COG0457	Tetratricopeptide repeat
DSB67_RS05515	COG2824	Alkylphosphonate utilization operon protein PhnA
DSB67_RS05525	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DSB67_RS05530	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DSB67_RS05545	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
DSB67_RS05565	COG3568	Endonuclease Exonuclease Phosphatase
DSB67_RS05585	COG0402	S-adenosylhomocysteine deaminase activity
DSB67_RS05610	COG0583	DNA-binding transcription factor activity
DSB67_RS05620	COG0686	Belongs to the AlaDH PNT family
DSB67_RS05630	COG1674	ftsk spoiiie
DSB67_RS05640	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DSB67_RS05650	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DSB67_RS05670	COG2226	methyltransferase
DSB67_RS05695	COG0300	oxidoreductase activity
DSB67_RS05710	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DSB67_RS05730	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DSB67_RS05750	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DSB67_RS05760	COG1757	Na H antiporter
DSB67_RS05770	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DSB67_RS05780	COG0131	Imidazoleglycerol-phosphate dehydratase
DSB67_RS05780	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
DSB67_RS05785	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DSB67_RS05790	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DSB67_RS05800	COG0140	phosphoribosyl-ATP diphosphatase activity
DSB67_RS05800	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DSB67_RS05805	COG3012	SEC-C Motif Domain Protein
DSB67_RS05810	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
DSB67_RS05815	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DSB67_RS05820	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DSB67_RS05825	COG0215	cysteine-tRNA ligase activity
DSB67_RS05830	COG1435	thymidine kinase activity
DSB67_RS05835	COG1434	Gram-negative-bacterium-type cell wall biogenesis
DSB67_RS05855	COG2116	formate transmembrane transporter activity
DSB67_RS05860	COG0390	transport system, permease component
DSB67_RS05865	COG4459	periplasmic nitrate reductase
DSB67_RS05870	COG3005	denitrification pathway
DSB67_RS05875	COG0243	molybdopterin cofactor binding
DSB67_RS05890	COG1121	(ABC) transporter
DSB67_RS05895	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DSB67_RS05900	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DSB67_RS05905	COG1227	inorganic diphosphatase activity
DSB67_RS05915	COG4172	Belongs to the ABC transporter superfamily
DSB67_RS05925	COG4171	peptide transport system, permease
DSB67_RS05930	COG4168	peptide transport system, permease
DSB67_RS05940	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
DSB67_RS05945	COG1842	Phage shock protein A
DSB67_RS05955	COG1983	PspC domain protein
DSB67_RS05965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DSB67_RS05975	COG2818	Glycosylase
DSB67_RS05995	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
DSB67_RS06000	COG0626	cystathionine gamma-synthase activity
DSB67_RS06010	COG0733	neurotransmitter:sodium symporter activity
DSB67_RS06015	COG0564	pseudouridine synthase activity
DSB67_RS06025	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DSB67_RS06030	COG1151	hydroxylamine reductase activity
DSB67_RS06035	COG3604	Transcriptional regulator
DSB67_RS06040	COG2814	Major facilitator Superfamily
DSB67_RS06050	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DSB67_RS06055	COG4136	ATPase activity
DSB67_RS06060	COG4135	transport system, permease component
DSB67_RS06065	COG4134	Bacterial extracellular solute-binding protein
DSB67_RS06080	COG0659	secondary active sulfate transmembrane transporter activity
DSB67_RS06090	COG3313	Fe-S protein
DSB67_RS06150	COG1061	Type III restriction enzyme res subunit
DSB67_RS06155	COG1187	pseudouridine synthase activity
DSB67_RS06160	COG2814	Major facilitator Superfamily
DSB67_RS06175	COG0702	epimerase
DSB67_RS06180	COG0534	Mate efflux family protein
DSB67_RS06185	COG4181	ATPase activity
DSB67_RS06215	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DSB67_RS06225	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DSB67_RS06235	COG1737	Transcriptional regulator
DSB67_RS06240	COG0076	glutamate decarboxylase activity
DSB67_RS06250	COG2431	L-lysine efflux transmembrane transporter activity
DSB67_RS06270	COG3070	regulator of competence-specific genes
DSB67_RS06285	COG4191	Histidine kinase
DSB67_RS06285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DSB67_RS06295	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DSB67_RS06330	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
DSB67_RS06335	COG4988	ABC transporter
DSB67_RS06340	COG0492	ferredoxin-NADP+ reductase activity
DSB67_RS06345	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DSB67_RS06365	COG0471	metal ion transport
DSB67_RS06370	COG2949	membrane
DSB67_RS06380	COG1643	Atp-dependent helicase
DSB67_RS06440	COG0277	FAD linked oxidase domain protein
DSB67_RS06440	COG0247	lactate metabolic process
DSB67_RS06485	COG2986	histidine ammonia-lyase
DSB67_RS06495	COG0010	Belongs to the arginase family
DSB67_RS06505	COG2188	Transcriptional regulator
DSB67_RS06540	COG0641	radical SAM
DSB67_RS06545	COG3119	arylsulfatase activity
DSB67_RS06560	COG0251	oxidation-reduction process
DSB67_RS06600	COG3706	GGDEF domain
DSB67_RS06610	COG0072	phenylalanine-tRNA ligase activity
DSB67_RS06610	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DSB67_RS06615	COG3433	isochorismatase activity
DSB67_RS06615	COG1535	isochorismatase
DSB67_RS06620	COG1132	(ABC) transporter
DSB67_RS06635	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DSB67_RS06655	COG4774	siderophore transport
DSB67_RS06660	COG4607	ABC-type enterochelin transport system periplasmic component
DSB67_RS06665	COG4605	iron ion homeostasis
DSB67_RS06670	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DSB67_RS06715	COG1346	cytolysis
DSB67_RS06725	COG2925	Exonuclease
DSB67_RS06735	COG1823	symporter activity
DSB67_RS06740	COG0702	epimerase
DSB67_RS06750	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DSB67_RS06760	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
DSB67_RS06770	COG2062	phosphohistidine phosphatase, SixA
DSB67_RS06785	COG4139	cobalamin transport
DSB67_RS06815	COG0583	DNA-binding transcription factor activity
DSB67_RS06825	COG1451	nucleotide metabolic process
DSB67_RS06910	COG2195	Cleaves the N-terminal amino acid of tripeptides
DSB67_RS06925	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
DSB67_RS06935	COG0625	glutathione transferase activity
DSB67_RS06990	COG0318	PFAM AMP-dependent synthetase and ligase
DSB67_RS07005	COG0668	transmembrane transport
DSB67_RS07010	COG3247	response to pH
DSB67_RS07025	COG1846	Transcriptional regulator
DSB67_RS07040	COG0693	protein deglycase activity
DSB67_RS07055	COG2205	protein histidine kinase activity
DSB67_RS07055	COG0784	Response regulator, receiver
DSB67_RS07080	COG4999	Histidine kinase
DSB67_RS07080	COG3850	Histidine kinase
DSB67_RS07080	COG3437	response regulator, receiver
DSB67_RS07080	COG2205	protein histidine kinase activity
DSB67_RS07085	COG5001	Diguanylate cyclase
DSB67_RS07085	COG3300	MHYT domain
DSB67_RS07115	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DSB67_RS07120	COG1215	transferase activity, transferring glycosyl groups
DSB67_RS07125	COG0438	transferase activity, transferring glycosyl groups
DSB67_RS07160	COG0438	transferase activity, transferring glycosyl groups
DSB67_RS07165	COG2204	response regulator
DSB67_RS07185	COG2885	chlorophyll binding
DSB67_RS07195	COG1793	dna ligase
DSB67_RS07205	COG0534	Mate efflux family protein
DSB67_RS07210	COG0307	riboflavin synthase, alpha
DSB67_RS07220	COG3001	Fructosamine kinase
DSB67_RS07225	COG2201	protein-glutamate methylesterase activity
DSB67_RS07230	COG3706	GGDEF domain
DSB67_RS07240	COG0791	NLP P60 protein
DSB67_RS07295	COG3148	PFAM DTW domain containing protein
DSB67_RS07300	COG1940	carbohydrate kinase activity
DSB67_RS07310	COG0303	'Molybdopterin
DSB67_RS07320	COG3842	ATPase activity
DSB67_RS07325	COG4662	Binding-protein-dependent transport system inner membrane component
DSB67_RS07335	COG2204	response regulator
DSB67_RS07340	COG4191	Histidine kinase
DSB67_RS07360	COG0488	(ABC) transporter
DSB67_RS07365	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DSB67_RS07385	COG3381	protein complex oligomerization
DSB67_RS07395	COG3383	formate dehydrogenase (NAD+) activity
DSB67_RS07395	COG0243	molybdopterin cofactor binding
DSB67_RS07400	COG0437	4 iron, 4 sulfur cluster binding
DSB67_RS07415	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DSB67_RS07420	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
DSB67_RS07430	COG1177	transmembrane transport
DSB67_RS07440	COG3842	ATPase activity
DSB67_RS07470	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DSB67_RS07485	COG2217	Heavy metal translocating P-type atpase
DSB67_RS07495	COG2010	Cytochrome c
DSB67_RS07510	COG3278	Belongs to the heme-copper respiratory oxidase family
DSB67_RS07675	COG1067	ATP-dependent peptidase activity
DSB67_RS07695	COG0488	(ABC) transporter
DSB67_RS07725	COG2902	Dehydrogenase
DSB67_RS07735	COG0308	aminopeptidase N
DSB67_RS07750	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
DSB67_RS07755	COG1956	GAF domain-containing protein
DSB67_RS07760	COG1132	(ABC) transporter
DSB67_RS07765	COG2995	paraquat-inducible protein a
DSB67_RS07770	COG3008	intermembrane lipid transfer
DSB67_RS07795	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DSB67_RS07815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DSB67_RS07820	COG4597	amino acid ABC transporter
DSB67_RS07825	COG0765	amino acid transport
DSB67_RS07830	COG1126	abc transporter atp-binding protein
DSB67_RS07835	COG0670	Belongs to the BI1 family
DSB67_RS07840	COG2920	part of a sulfur-relay system
DSB67_RS07845	COG1254	Belongs to the acylphosphatase family
DSB67_RS07850	COG0840	transmembrane signaling receptor activity
DSB67_RS07905	COG3706	GGDEF domain
DSB67_RS07915	COG0602	queuosine metabolic process
DSB67_RS07920	COG0561	phosphatase activity
DSB67_RS07955	COG2828	Protein conserved in bacteria
DSB67_RS07965	COG0372	Belongs to the citrate synthase family
DSB67_RS07970	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
DSB67_RS07980	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
DSB67_RS07995	COG1030	water channel activity
DSB67_RS08180	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
DSB67_RS08190	COG0484	heat shock protein binding
DSB67_RS08245	COG1403	HNH endonuclease
DSB67_RS08265	COG1802	Transcriptional regulator
DSB67_RS08265	COG4626	Terminase
DSB67_RS08305	COG0582	viral genome integration into host DNA
DSB67_RS08380	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DSB67_RS08380	COG0517	IMP dehydrogenase activity
DSB67_RS08450	COG2358	TRAP transporter, solute receptor (TAXI family
DSB67_RS08455	COG1012	belongs to the aldehyde dehydrogenase family
DSB67_RS08460	COG3284	Transcriptional regulator
DSB67_RS08465	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
DSB67_RS08470	COG0363	glucosamine-6-phosphate deaminase activity
DSB67_RS08475	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DSB67_RS08480	COG4565	transcriptional regulatory protein
DSB67_RS08485	COG3290	protein histidine kinase activity
DSB67_RS08500	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DSB67_RS08540	COG0454	-acetyltransferase
DSB67_RS08575	COG1280	lysine exporter protein (LysE YggA)
DSB67_RS08585	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
DSB67_RS08590	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DSB67_RS08635	COG1404	Belongs to the peptidase S8 family
DSB67_RS08655	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DSB67_RS08665	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
DSB67_RS08675	COG0215	cysteine-tRNA ligase activity
DSB67_RS08690	COG1368	sulfuric ester hydrolase activity
DSB67_RS08715	COG1115	amino acid carrier protein
DSB67_RS08750	COG1280	lysine exporter protein (LysE YggA)
DSB67_RS08770	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
DSB67_RS08790	COG1560	Kdo2-lipid A biosynthetic process
DSB67_RS08795	COG1280	lysine exporter protein (LysE YggA)
DSB67_RS08830	COG3063	Type IV pilus biogenesis stability protein PilW
DSB67_RS08855	COG1643	Atp-dependent helicase
DSB67_RS08895	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
DSB67_RS08905	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
DSB67_RS08945	COG3227	Zinc metalloprotease (Elastase)
DSB67_RS08975	COG3706	GGDEF domain
DSB67_RS08985	COG0443	Heat shock 70 kDa protein
DSB67_RS08990	COG0443	Heat shock 70 kDa protein
DSB67_RS09015	COG0583	DNA-binding transcription factor activity
DSB67_RS09025	COG1132	(ABC) transporter
DSB67_RS09030	COG1132	(ABC) transporter
DSB67_RS09040	COG4774	siderophore transport
DSB67_RS09050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DSB67_RS09055	COG1120	ATPase activity
DSB67_RS09070	COG0814	amino acid
DSB67_RS09075	COG1454	alcohol dehydrogenase
DSB67_RS09080	COG4221	oxidoreductase activity
DSB67_RS09085	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
DSB67_RS09095	COG0861	Integral membrane protein TerC family
DSB67_RS09105	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DSB67_RS09110	COG1328	CTP reductase activity
DSB67_RS09115	COG1280	lysine exporter protein (LysE YggA)
DSB67_RS09135	COG0456	acetyltransferase
DSB67_RS09165	COG3340	Belongs to the peptidase S51 family
DSB67_RS09255	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DSB67_RS09255	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DSB67_RS09285	COG1280	lysine exporter protein (LysE YggA)
DSB67_RS09455	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DSB67_RS09470	COG3106	COG3106 Predicted ATPase
DSB67_RS09485	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DSB67_RS09490	COG2205	protein histidine kinase activity
DSB67_RS09490	COG0784	Response regulator, receiver
DSB67_RS09505	COG0814	amino acid
DSB67_RS09510	COG1760	l-serine dehydratase
DSB67_RS09515	COG3300	MHYT domain
DSB67_RS09515	COG5001	Diguanylate cyclase
DSB67_RS09525	COG2197	response regulator
DSB67_RS09530	COG0720	synthase
DSB67_RS09540	COG0017	Asparaginyl-tRNA synthetase
DSB67_RS09555	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DSB67_RS09575	COG1448	Aminotransferase
DSB67_RS09595	COG0840	transmembrane signaling receptor activity
DSB67_RS09600	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DSB67_RS09605	COG1846	Transcriptional regulator
DSB67_RS09645	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DSB67_RS09650	COG3108	Peptidase M15
DSB67_RS09655	COG2989	Protein conserved in bacteria
DSB67_RS09705	COG1138	Cytochrome C-type biogenesis protein
DSB67_RS09735	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DSB67_RS09740	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DSB67_RS09750	COG1546	Belongs to the CinA family
DSB67_RS09750	COG1058	Belongs to the CinA family
DSB67_RS09765	COG0019	diaminopimelate decarboxylase activity
DSB67_RS09805	COG0322	excinuclease ABC activity
DSB67_RS09810	COG2197	response regulator
DSB67_RS09815	COG0417	DNA replication proofreading
DSB67_RS09835	COG1187	pseudouridine synthase activity
DSB67_RS09845	COG0009	L-threonylcarbamoyladenylate synthase
DSB67_RS09850	COG0613	PHP domain protein
DSB67_RS09860	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DSB67_RS09865	COG0512	Glutamine amidotransferase of anthranilate synthase
DSB67_RS09875	COG0134	indole-3-glycerol-phosphate synthase activity
DSB67_RS09875	COG0135	phosphoribosylanthranilate isomerase activity
DSB67_RS09885	COG0159	tryptophan synthase activity
DSB67_RS09890	COG1301	dicarboxylic acid transport
DSB67_RS09915	COG2350	Protein conserved in bacteria
DSB67_RS09945	COG1716	ATPase activity
DSB67_RS09945	COG5001	Diguanylate cyclase
DSB67_RS09950	COG1032	radical SAM domain protein
DSB67_RS10000	COG2175	clavaminate synthase activity
DSB67_RS10015	COG0840	transmembrane signaling receptor activity
DSB67_RS10025	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DSB67_RS10030	COG0463	Glycosyl transferase, family 2
DSB67_RS10035	COG0745	RESPONSE REGULATOR receiver
DSB67_RS10040	COG3850	Histidine kinase
DSB67_RS10040	COG5002	protein histidine kinase activity
DSB67_RS10095	COG3708	Transcriptional regulator
DSB67_RS10095	COG2207	Transcriptional regulator
DSB67_RS10105	COG1217	gtp-binding protein TYPA
DSB67_RS10115	COG2176	DNA-directed DNA polymerase activity
DSB67_RS10135	COG1136	(ABC) transporter
DSB67_RS10135	COG0577	efflux transmembrane transporter activity
DSB67_RS10140	COG0577	efflux transmembrane transporter activity
DSB67_RS10140	COG1136	(ABC) transporter
DSB67_RS10145	COG0577	efflux transmembrane transporter activity
DSB67_RS10155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DSB67_RS10180	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DSB67_RS10190	COG3118	belongs to the thioredoxin family
DSB67_RS10210	COG2995	paraquat-inducible protein a
DSB67_RS10215	COG3008	intermembrane lipid transfer
DSB67_RS10215	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DSB67_RS10220	COG3009	Protein conserved in bacteria
DSB67_RS10235	COG4166	transmembrane transport
DSB67_RS10245	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
DSB67_RS10250	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
DSB67_RS10260	COG0539	negative regulation of cytoplasmic translation
DSB67_RS10270	COG0616	signal peptide processing
DSB67_RS10275	COG1028	Short-chain dehydrogenase reductase Sdr
DSB67_RS10295	COG0835	chemotaxis
DSB67_RS10295	COG0784	Response regulator, receiver
DSB67_RS10300	COG1940	carbohydrate kinase activity
DSB67_RS10315	COG4667	esterase of the alpha-beta hydrolase superfamily
DSB67_RS10330	COG0733	neurotransmitter:sodium symporter activity
DSB67_RS10345	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DSB67_RS10345	COG1263	PTS System
DSB67_RS10350	COG0084	hydrolase, TatD family'
DSB67_RS10365	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DSB67_RS10395	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DSB67_RS10410	COG1399	metal-binding, possibly nucleic acid-binding protein
DSB67_RS10415	COG0424	maF-like protein
DSB67_RS10420	COG0564	pseudouridine synthase activity
DSB67_RS10425	COG1530	ribonuclease E activity
DSB67_RS10435	COG0659	secondary active sulfate transmembrane transporter activity
DSB67_RS10440	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DSB67_RS10445	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
DSB67_RS10475	COG2186	Transcriptional regulator
DSB67_RS10485	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
DSB67_RS10490	COG0653	protein targeting
DSB67_RS10495	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DSB67_RS10500	COG2199	diguanylate cyclase activity
DSB67_RS10510	COG1122	ATPase activity
DSB67_RS10515	COG4120	Belongs to the binding-protein-dependent transport system permease family
DSB67_RS10535	COG0857	belongs to the CobB CobQ family
DSB67_RS10535	COG0280	phosphate acetyltransferase
DSB67_RS10540	COG0435	Glutathione S-transferase
DSB67_RS10550	COG0444	Belongs to the ABC transporter superfamily
DSB67_RS10555	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DSB67_RS10560	COG0601	transmembrane transport
DSB67_RS10570	COG0314	molybdopterin synthase activity
DSB67_RS10575	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
DSB67_RS10585	COG0521	Mo-molybdopterin cofactor biosynthetic process
DSB67_RS10590	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DSB67_RS10595	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DSB67_RS10610	COG0556	nucleotide-excision repair
DSB67_RS10670	COG1882	Formate acetyltransferase
DSB67_RS10675	COG4657	Part of a membrane complex involved in electron transport
DSB67_RS10685	COG4656	Part of a membrane complex involved in electron transport
DSB67_RS10690	COG4658	electron transport chain
DSB67_RS10695	COG4659	FMN binding
DSB67_RS10700	COG4660	Part of a membrane complex involved in electron transport
DSB67_RS10705	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DSB67_RS10710	COG0346	lactoylglutathione lyase activity
DSB67_RS10720	COG2885	chlorophyll binding
DSB67_RS10730	COG2056	Na+-H+ antiporter family
DSB67_RS10745	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DSB67_RS10760	COG1028	Short-chain dehydrogenase reductase Sdr
DSB67_RS10765	COG1454	alcohol dehydrogenase
DSB67_RS10765	COG1012	belongs to the aldehyde dehydrogenase family
DSB67_RS10770	COG2095	MarC family integral membrane protein
DSB67_RS10775	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DSB67_RS10785	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DSB67_RS10790	COG1757	Na H antiporter
DSB67_RS10815	COG3083	sulfuric ester hydrolase activity
DSB67_RS10830	COG4269	membrane
DSB67_RS10840	COG0123	including yeast histone deacetylase and acetoin utilization protein
DSB67_RS10855	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DSB67_RS10860	COG0778	Nitroreductase
DSB67_RS10865	COG1902	pentaerythritol trinitrate reductase activity
DSB67_RS10865	COG0446	pyridine nucleotide-disulphide oxidoreductase
DSB67_RS10870	COG0616	signal peptide processing
DSB67_RS10875	COG0252	asparaginase activity
DSB67_RS10880	COG3139	Protein of unknown function (DUF1315)
DSB67_RS10890	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DSB67_RS10895	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DSB67_RS10915	COG2226	methyltransferase
DSB67_RS10935	COG1785	Belongs to the alkaline phosphatase family
DSB67_RS10945	COG0346	lactoylglutathione lyase activity
DSB67_RS10955	COG0668	transmembrane transport
DSB67_RS10960	COG0076	glutamate decarboxylase activity
DSB67_RS10965	COG2985	domain, Protein
DSB67_RS10970	COG2261	transglycosylase associated protein
DSB67_RS10975	COG2983	Belongs to the UPF0260 family
DSB67_RS10985	COG2964	Protein conserved in bacteria
DSB67_RS10995	COG0251	oxidation-reduction process
DSB67_RS11000	COG0814	amino acid
DSB67_RS11005	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DSB67_RS11010	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DSB67_RS11020	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DSB67_RS11030	COG2832	Protein of unknown function (DUF454)
DSB67_RS11040	COG0745	RESPONSE REGULATOR receiver
DSB67_RS11045	COG0583	DNA-binding transcription factor activity
DSB67_RS11050	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DSB67_RS11055	COG1286	toxin biosynthetic process
DSB67_RS11060	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
DSB67_RS11065	COG0285	dihydrofolate synthase activity
DSB67_RS11090	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DSB67_RS11095	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DSB67_RS11105	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DSB67_RS11125	COG3101	peptidyl-lysine hydroxylation
DSB67_RS11130	COG2860	membrane
DSB67_RS11145	COG2890	protein-(glutamine-N5) methyltransferase activity
DSB67_RS11155	COG2062	phosphohistidine phosphatase, SixA
DSB67_RS11170	COG0183	Belongs to the thiolase family
DSB67_RS11190	COG2067	long-chain fatty acid transport protein
DSB67_RS11195	COG2067	long-chain fatty acid transport protein
DSB67_RS11200	COG2853	Lipoprotein
DSB67_RS11205	COG3088	subunit of a heme lyase
DSB67_RS11205	COG4235	cytochrome complex assembly
DSB67_RS11215	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DSB67_RS11220	COG1138	Cytochrome C-type biogenesis protein
DSB67_RS11235	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DSB67_RS11240	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DSB67_RS11245	COG4133	protoheme IX ABC transporter activity
DSB67_RS11255	COG0835	chemotaxis
DSB67_RS11265	COG1192	Involved in chromosome partitioning
DSB67_RS11270	COG2201	protein-glutamate methylesterase activity
DSB67_RS11275	COG0784	Response regulator, receiver
DSB67_RS11275	COG0643	Histidine kinase
DSB67_RS11275	COG2198	Histidine kinase
DSB67_RS11280	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
DSB67_RS11315	COG1684	flagellar biosynthetic protein fliR
DSB67_RS11320	COG1987	bacterial-type flagellum assembly
DSB67_RS11375	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DSB67_RS11385	COG1677	Flagellar hook-basal body complex protein FliE
DSB67_RS11405	COG1516	flagellar protein fliS
DSB67_RS11415	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
DSB67_RS11420	COG1334	flagellar protein FlaG
DSB67_RS11425	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DSB67_RS11430	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DSB67_RS11440	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DSB67_RS11445	COG2837	iron assimilation
DSB67_RS11470	COG1393	Belongs to the ArsC family
DSB67_RS11490	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
DSB67_RS11495	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DSB67_RS11500	COG2716	regulation of RNA biosynthetic process
DSB67_RS11505	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DSB67_RS11520	COG4783	chaperone-mediated protein folding
DSB67_RS11525	COG1393	Belongs to the ArsC family
DSB67_RS11545	COG2233	PERMEase
DSB67_RS11550	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DSB67_RS11555	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DSB67_RS11560	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DSB67_RS11565	COG0121	glutamine amidotransferase
DSB67_RS11570	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
DSB67_RS11575	COG1960	acyl-CoA dehydrogenase activity
DSB67_RS11600	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DSB67_RS11610	COG2226	methyltransferase
DSB67_RS11620	COG0741	lytic transglycosylase activity
DSB67_RS11620	COG1388	LysM domain
DSB67_RS11635	COG0347	Belongs to the P(II) protein family
DSB67_RS11655	COG0587	DNA-directed DNA polymerase activity
DSB67_RS11680	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DSB67_RS11685	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
DSB67_RS11695	COG0750	zinc metalloprotease
DSB67_RS11705	COG0575	Belongs to the CDS family
DSB67_RS11710	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DSB67_RS11735	COG0024	Methionine aminopeptidase
DSB67_RS11750	COG0564	pseudouridine synthase activity
DSB67_RS11755	COG3098	single-species biofilm formation
DSB67_RS11790	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
DSB67_RS11805	COG1720	tRNA m6t6A37 methyltransferase activity
DSB67_RS11830	COG0733	neurotransmitter:sodium symporter activity
DSB67_RS11845	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DSB67_RS11850	COG0514	ATP-dependent DNA helicase (RecQ)
DSB67_RS11855	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DSB67_RS11870	COG1477	protein flavinylation
DSB67_RS11880	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
DSB67_RS11885	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
DSB67_RS11895	COG1805	sodium ion transport
DSB67_RS11900	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
DSB67_RS11905	COG0271	Belongs to the BolA IbaG family
DSB67_RS11935	COG1595	DNA-templated transcription, initiation
DSB67_RS11960	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DSB67_RS11965	COG0693	protein deglycase activity
DSB67_RS11970	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DSB67_RS11975	COG2166	iron-sulfur cluster assembly
DSB67_RS11980	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DSB67_RS11985	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
DSB67_RS12000	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DSB67_RS12000	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DSB67_RS12010	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DSB67_RS12015	COG1074	ATP-dependent DNA helicase activity
DSB67_RS12020	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
DSB67_RS12025	COG3083	sulfuric ester hydrolase activity
DSB67_RS12045	COG3141	response to X-ray
DSB67_RS12065	COG2171	N-acyltransferase activity
DSB67_RS12070	COG0584	glycerophosphoryl diester phosphodiesterase
DSB67_RS12075	COG2271	Major facilitator Superfamily
DSB67_RS12085	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DSB67_RS12095	COG1349	DNA-binding transcription factor activity
DSB67_RS12100	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DSB67_RS12120	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DSB67_RS12125	COG0768	penicillin binding
DSB67_RS12130	COG1609	Transcriptional regulator
DSB67_RS12135	COG0583	DNA-binding transcription factor activity
DSB67_RS12145	COG1022	Amp-dependent synthetase and ligase
DSB67_RS12175	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DSB67_RS12180	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DSB67_RS12190	COG0560	Phosphoserine phosphatase
DSB67_RS12200	COG0813	purine-nucleoside phosphorylase activity
DSB67_RS12210	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
DSB67_RS12220	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DSB67_RS12225	COG0084	hydrolase, TatD family'
DSB67_RS12250	COG3153	acetyltransferase
DSB67_RS12255	COG3154	lipid carrier protein
DSB67_RS12265	COG0826	peptidase U32
DSB67_RS12270	COG0826	peptidase U32
DSB67_RS12275	COG0534	Mate efflux family protein
DSB67_RS12295	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DSB67_RS12315	COG0195	Participates in both transcription termination and antitermination
DSB67_RS12335	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DSB67_RS12350	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DSB67_RS12355	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DSB67_RS12365	COG1534	Rna-binding protein
DSB67_RS12370	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DSB67_RS12375	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
DSB67_RS12380	COG2027	D-alanyl-D-alanine carboxypeptidase
DSB67_RS12395	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DSB67_RS12400	COG0739	heme binding
DSB67_RS12405	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DSB67_RS12425	COG0628	permease
DSB67_RS12440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DSB67_RS12440	COG0784	Response regulator, receiver
DSB67_RS12440	COG2205	protein histidine kinase activity
DSB67_RS12440	COG2198	Histidine kinase
DSB67_RS12445	COG0747	negative chemotaxis
DSB67_RS12455	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DSB67_RS12460	COG0444	Belongs to the ABC transporter superfamily
DSB67_RS12465	COG4608	Belongs to the ABC transporter superfamily
DSB67_RS12475	COG2971	BadF BadG BcrA BcrD
DSB67_RS12490	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DSB67_RS12495	COG3842	ATPase activity
DSB67_RS12505	COG1840	ABC-type Fe3 transport system, periplasmic component
DSB67_RS12510	COG0004	ammonium transporteR
DSB67_RS12525	COG1049	propionate catabolic process, 2-methylcitrate cycle
DSB67_RS12530	COG1752	Esterase of the alpha-beta hydrolase superfamily
DSB67_RS12535	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DSB67_RS12540	COG1643	Atp-dependent helicase
DSB67_RS12555	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DSB67_RS12570	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DSB67_RS12585	COG1560	Kdo2-lipid A biosynthetic process
DSB67_RS12590	COG0842	Transport permease protein
DSB67_RS12595	COG1131	(ABC) transporter
DSB67_RS12600	COG0659	secondary active sulfate transmembrane transporter activity
DSB67_RS12605	COG0288	reversible hydration of carbon dioxide
DSB67_RS12625	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DSB67_RS12630	COG0508	dehydrogenase complex catalyzes the overall conversion of
DSB67_RS12635	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
DSB67_RS12640	COG2186	Transcriptional regulator
DSB67_RS12660	COG4969	Belongs to the N-Me-Phe pilin family
DSB67_RS12665	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DSB67_RS12670	COG1459	type II secretion system
DSB67_RS12680	COG0237	dephospho-CoA kinase activity
DSB67_RS12685	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
DSB67_RS12690	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
DSB67_RS12715	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DSB67_RS12720	COG4137	Cytochrome C assembly protein
DSB67_RS12725	COG4536	flavin adenine dinucleotide binding
DSB67_RS12745	COG0612	Peptidase, M16
DSB67_RS12750	COG1238	metal cluster binding
DSB67_RS12760	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
DSB67_RS12765	COG5016	pyruvate
DSB67_RS12765	COG0511	ligase activity, forming carbon-carbon bonds
DSB67_RS12770	COG3630	sodium ion export across plasma membrane
DSB67_RS12860	COG0527	aspartate kinase activity
DSB67_RS12875	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DSB67_RS12880	COG1546	Belongs to the CinA family
DSB67_RS12890	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DSB67_RS12920	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DSB67_RS12930	COG0148	phosphopyruvate hydratase activity
DSB67_RS12940	COG3956	TIGRFAM MazG family protein
DSB67_RS12945	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DSB67_RS12970	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
DSB67_RS12975	COG1381	Involved in DNA repair and RecF pathway recombination
DSB67_RS12980	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DSB67_RS13000	COG3086	response to oxidative stress
DSB67_RS13015	COG1595	DNA-templated transcription, initiation
DSB67_RS13020	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DSB67_RS13030	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
DSB67_RS13050	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DSB67_RS13055	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DSB67_RS13070	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
DSB67_RS13080	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DSB67_RS13090	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DSB67_RS13100	COG0583	DNA-binding transcription factor activity
DSB67_RS13115	COG0668	transmembrane transport
DSB67_RS13120	COG0191	fructose-bisphosphate aldolase activity
DSB67_RS13140	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DSB67_RS13160	COG2356	endonuclease I
DSB67_RS13165	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DSB67_RS13170	COG0189	ligase activity
DSB67_RS13175	COG1678	Uncharacterized ACR, COG1678
DSB67_RS13180	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DSB67_RS13195	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DSB67_RS13200	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DSB67_RS13205	COG0762	integral membrane protein
DSB67_RS13220	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DSB67_RS13225	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DSB67_RS13325	COG1012	belongs to the aldehyde dehydrogenase family
DSB67_RS13380	COG1609	Transcriptional regulator
DSB67_RS13390	COG1486	melibiose metabolic process
DSB67_RS13395	COG1447	Phosphotransferase system cellobiose-specific component IIA
DSB67_RS13410	COG0726	polysaccharide deacetylase
DSB67_RS13420	COG1028	Short-chain dehydrogenase reductase Sdr
DSB67_RS13430	COG0795	lipopolysaccharide-transporting ATPase activity
DSB67_RS13435	COG0795	lipopolysaccharide-transporting ATPase activity
DSB67_RS13445	COG2927	DNA polymerase III (CHI subunit)
DSB67_RS13450	COG0525	valine-tRNA ligase activity
DSB67_RS13500	COG0251	oxidation-reduction process
DSB67_RS13505	COG0204	Acyl-transferase
DSB67_RS13515	COG5007	Belongs to the BolA IbaG family
DSB67_RS13525	COG2854	intermembrane phospholipid transfer
DSB67_RS13530	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DSB67_RS13535	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DSB67_RS13540	COG1127	ABC transporter
DSB67_RS13550	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DSB67_RS13550	COG0517	IMP dehydrogenase activity
DSB67_RS13560	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
DSB67_RS13565	COG1137	ATPase activity
DSB67_RS13575	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DSB67_RS13580	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DSB67_RS13590	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DSB67_RS13595	COG2239	Acts as a magnesium transporter
DSB67_RS13600	COG0312	modulator of DNA gyrase
DSB67_RS13610	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DSB67_RS13615	COG0564	pseudouridine synthase activity
DSB67_RS13630	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DSB67_RS13635	COG0312	modulator of DNA gyrase
DSB67_RS13640	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DSB67_RS13645	COG3164	Protein of unknown function
DSB67_RS13655	COG0424	maF-like protein
DSB67_RS13660	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
DSB67_RS13665	COG1792	Involved in formation and maintenance of cell shape
DSB67_RS13670	COG1077	Cell shape determining protein MreB Mrl
DSB67_RS13705	COG2165	general secretion pathway protein
DSB67_RS13715	COG1459	type II secretion system
DSB67_RS13720	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DSB67_RS13730	COG3409	Peptidoglycan-binding domain 1 protein
DSB67_RS13730	COG3267	Type II secretory pathway component ExeA
DSB67_RS13755	COG2199	diguanylate cyclase activity
DSB67_RS13755	COG2200	EAL domain
DSB67_RS13760	COG0629	single-stranded DNA binding
DSB67_RS13775	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DSB67_RS13785	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DSB67_RS13795	COG0527	aspartate kinase activity
DSB67_RS13800	COG1410	methionine synthase
DSB67_RS13800	COG0646	methionine synthase
DSB67_RS13870	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DSB67_RS13890	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DSB67_RS13895	COG0735	belongs to the Fur family
DSB67_RS13910	COG0432	Pfam Uncharacterised protein family UPF0047
DSB67_RS13920	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DSB67_RS13925	COG0305	Participates in initiation and elongation during chromosome replication
DSB67_RS13945	COG2965	DNA replication, synthesis of RNA primer
DSB67_RS13955	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DSB67_RS13960	COG0338	D12 class N6 adenine-specific DNA methyltransferase
DSB67_RS14005	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
DSB67_RS14015	COG0678	peroxiredoxin activity
DSB67_RS14015	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DSB67_RS14020	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DSB67_RS14035	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DSB67_RS14035	COG0165	Argininosuccinate lyase
DSB67_RS14050	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DSB67_RS14060	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
DSB67_RS14070	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DSB67_RS14075	COG0527	aspartate kinase activity
DSB67_RS14075	COG0460	homoserine dehydrogenase
DSB67_RS14080	COG0626	cystathionine gamma-synthase activity
DSB67_RS14090	COG0281	malic enzyme
DSB67_RS14100	COG2906	2 iron, 2 sulfur cluster binding
DSB67_RS14110	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DSB67_RS14125	COG2168	tRNA wobble position uridine thiolation
DSB67_RS14130	COG2923	Belongs to the DsrF TusC family
DSB67_RS14135	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
DSB67_RS14140	COG2964	Protein conserved in bacteria
DSB67_RS14145	COG0545	Peptidyl-prolyl cis-trans isomerase
DSB67_RS14160	COG1446	asparaginase
DSB67_RS14170	COG1047	Peptidyl-prolyl cis-trans
DSB67_RS14185	COG2249	NAD(P)H dehydrogenase (quinone) activity
DSB67_RS14195	COG0488	(ABC) transporter
DSB67_RS14205	COG0429	hydrolase of the alpha beta-hydrolase fold
DSB67_RS14215	COG3954	Phosphoribulokinase
DSB67_RS14220	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DSB67_RS14240	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DSB67_RS14245	COG0512	Glutamine amidotransferase of anthranilate synthase
DSB67_RS14260	COG0546	phosphoglycolate phosphatase activity
DSB67_RS14265	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DSB67_RS14270	COG0557	exoribonuclease II activity
DSB67_RS14280	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DSB67_RS14280	COG1017	nitric oxide dioxygenase activity
DSB67_RS14285	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
DSB67_RS14295	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DSB67_RS14300	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
DSB67_RS14305	COG0330	HflC and HflK could
DSB67_RS14310	COG0330	HflC and HflK could
DSB67_RS14315	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DSB67_RS14330	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DSB67_RS14335	COG0860	N-Acetylmuramoyl-L-alanine amidase
DSB67_RS14340	COG0802	atpase or kinase
DSB67_RS14345	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DSB67_RS14425	COG1162	GTPase activity
DSB67_RS14435	COG0471	metal ion transport
DSB67_RS14450	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
DSB67_RS14455	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DSB67_RS14470	COG1045	serine acetyltransferase
DSB67_RS14475	COG4942	peptidase
DSB67_RS14500	COG1053	succinate dehydrogenase
DSB67_RS14505	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DSB67_RS14535	COG1509	lysine 2,3-aminomutase activity
DSB67_RS14565	COG0534	Mate efflux family protein
DSB67_RS14575	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DSB67_RS14585	COG0745	RESPONSE REGULATOR receiver
DSB67_RS14590	COG2205	protein histidine kinase activity
DSB67_RS14600	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DSB67_RS14605	COG3030	protein affecting phage T7 exclusion by the F plasmid
DSB67_RS14610	COG1027	Aspartate ammonia-lyase
DSB67_RS14615	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
DSB67_RS14620	COG4232	protein-disulfide reductase activity
DSB67_RS14630	COG2095	MarC family integral membrane protein
DSB67_RS14640	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DSB67_RS14660	COG2198	Histidine kinase
DSB67_RS14660	COG0784	Response regulator, receiver
DSB67_RS14660	COG2205	protein histidine kinase activity
DSB67_RS14665	COG2814	Major facilitator Superfamily
DSB67_RS14680	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DSB67_RS14685	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DSB67_RS14690	COG0511	ligase activity, forming carbon-carbon bonds
DSB67_RS14695	COG0439	Biotin carboxylase
DSB67_RS14710	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DSB67_RS14715	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
DSB67_RS14720	COG2199	diguanylate cyclase activity
DSB67_RS14770	COG1982	Orn Lys Arg decarboxylase major
DSB67_RS14775	COG0531	amino acid
DSB67_RS14785	COG3710	Transcriptional regulator
DSB67_RS14790	COG0789	Transcriptional regulator
DSB67_RS14800	COG0151	Belongs to the GarS family
DSB67_RS14815	COG1253	flavin adenine dinucleotide binding
DSB67_RS14820	COG3068	Protein conserved in bacteria
DSB67_RS14830	COG1573	uracil-dna glycosylase
DSB67_RS14850	COG2816	NAD+ diphosphatase activity
DSB67_RS14855	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
DSB67_RS14875	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DSB67_RS14890	COG0250	Participates in transcription elongation, termination and antitermination
DSB67_RS14895	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DSB67_RS14940	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DSB67_RS14950	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DSB67_RS15045	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DSB67_RS15050	COG0534	Mate efflux family protein
DSB67_RS15070	COG2937	Belongs to the GPAT DAPAT family
DSB67_RS15080	COG3161	chorismate lyase activity
DSB67_RS15085	COG1580	Controls the rotational direction of flagella during chemotaxis
DSB67_RS15090	COG0705	Rhomboid family
DSB67_RS15110	COG2177	Part of the ABC transporter FtsEX involved in
DSB67_RS15115	COG2884	Cell division ATP-binding protein ftsE
DSB67_RS15120	COG0552	protein localization to endoplasmic reticulum
DSB67_RS15125	COG0742	ribosomal rna small subunit methyltransferase
DSB67_RS15135	COG2095	MarC family integral membrane protein
DSB67_RS15190	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DSB67_RS15195	COG0640	Transcriptional regulator
DSB67_RS15200	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
DSB67_RS15205	COG1280	lysine exporter protein (LysE YggA)
DSB67_RS15210	COG2267	carboxylic ester hydrolase activity
DSB67_RS15215	COG0561	phosphatase activity
DSB67_RS15230	COG3148	PFAM DTW domain containing protein
DSB67_RS15235	COG2199	diguanylate cyclase activity
DSB67_RS15235	COG2200	EAL domain
DSB67_RS15235	COG3287	FIST C domain
DSB67_RS15240	COG1011	Hydrolase
DSB67_RS15260	COG0019	diaminopimelate decarboxylase activity
DSB67_RS15275	COG3072	Adenylate cyclase
DSB67_RS15285	COG1587	Uroporphyrinogen-III synthase
DSB67_RS15290	COG2959	enzyme of heme biosynthesis
DSB67_RS15295	COG3071	HemY protein
DSB67_RS15345	COG0633	Ferredoxin
DSB67_RS15350	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
DSB67_RS15365	COG3118	belongs to the thioredoxin family
DSB67_RS15380	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
DSB67_RS15395	COG0514	ATP-dependent DNA helicase (RecQ)
DSB67_RS15400	COG2962	Rard protein
DSB67_RS15410	COG1280	lysine exporter protein (LysE YggA)
DSB67_RS15415	COG0405	Gamma-glutamyltransferase
DSB67_RS15425	COG0210	DNA helicase
DSB67_RS15435	COG3220	belongs to the UPF0276 family
DSB67_RS15455	COG2814	Major facilitator Superfamily
DSB67_RS15465	COG0006	proline dipeptidase activity
DSB67_RS15465	COG0006	proline dipeptidase activity
DSB67_RS15480	COG2104	thiamine diphosphate biosynthetic process
DSB67_RS15485	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DSB67_RS15505	COG2132	Multicopper oxidase
DSB67_RS15555	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DSB67_RS15580	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DSB67_RS15585	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DSB67_RS15590	COG0551	DNA topoisomerase type I activity
DSB67_RS15600	COG0758	DNA mediated transformation
DSB67_RS15610	COG0242	peptide deformylase activity
DSB67_RS15620	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DSB67_RS15620	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DSB67_RS15625	COG0569	domain protein
DSB67_RS15630	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DSB67_RS15640	COG1272	protein, Hemolysin III
DSB67_RS15645	COG4326	sporulation control protein
DSB67_RS15655	COG3084	Protein conserved in bacteria
DSB67_RS15665	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DSB67_RS15670	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DSB67_RS15675	COG0204	Acyl-transferase
DSB67_RS15685	COG2199	diguanylate cyclase activity
DSB67_RS15690	COG0606	chelatase, subunit chli
DSB67_RS15700	COG3978	acetolactate synthase activity
DSB67_RS15705	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DSB67_RS15710	COG0129	dihydroxy-acid dehydratase activity
DSB67_RS15720	COG0583	DNA-binding transcription factor activity
DSB67_RS15725	COG2814	Major facilitator Superfamily
DSB67_RS15730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DSB67_RS15735	COG0765	amino acid transport
DSB67_RS15745	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DSB67_RS15755	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DSB67_RS15785	COG3312	ion transport
DSB67_RS15790	COG1475	DNA binding
DSB67_RS15795	COG1192	Involved in chromosome partitioning
DSB67_RS15810	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DSB67_RS15840	COG1126	abc transporter atp-binding protein
DSB67_RS15935	COG0739	heme binding
DSB67_RS15950	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DSB67_RS15980	COG3069	C4-dicarboxylate transmembrane transporter activity
DSB67_RS16010	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DSB67_RS16020	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DSB67_RS16080	COG0784	Response regulator, receiver
DSB67_RS16080	COG2198	Histidine kinase
DSB67_RS16080	COG2205	protein histidine kinase activity
DSB67_RS16085	COG1879	ABC-type sugar transport system periplasmic component
DSB67_RS16095	COG0210	DNA helicase
DSB67_RS16100	COG1289	transmembrane transporter activity
DSB67_RS16125	COG0789	Transcriptional regulator
DSB67_RS16130	COG4604	ABC transporter, ATP-binding protein
DSB67_RS16135	COG4605	iron ion homeostasis
DSB67_RS16140	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DSB67_RS16145	COG4607	ABC-type enterochelin transport system periplasmic component
DSB67_RS16160	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
DSB67_RS16175	COG1609	Transcriptional regulator
DSB67_RS16180	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DSB67_RS16185	COG1879	ABC-type sugar transport system periplasmic component
DSB67_RS16190	COG1172	Belongs to the binding-protein-dependent transport system permease family
DSB67_RS16195	COG1129	ABC transporter
DSB67_RS16205	COG5001	Diguanylate cyclase
DSB67_RS16270	COG2205	protein histidine kinase activity
DSB67_RS16270	COG0784	Response regulator, receiver
DSB67_RS16295	COG0330	HflC and HflK could
DSB67_RS16310	COG4175	Glycine betaine
DSB67_RS16310	COG0517	IMP dehydrogenase activity
DSB67_RS16315	COG4176	ABC-type proline glycine betaine transport system permease component
DSB67_RS16350	COG2885	chlorophyll binding
DSB67_RS16390	COG0455	bacterial-type flagellum organization
DSB67_RS16400	COG4964	Belongs to the GSP D family
DSB67_RS16420	COG0583	DNA-binding transcription factor activity
DSB67_RS16455	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DSB67_RS16455	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DSB67_RS16470	COG4989	oxidoreductase activity
DSB67_RS16500	COG0303	'Molybdopterin
DSB67_RS16505	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DSB67_RS16540	COG2897	thiosulfate sulfurtransferase activity
DSB67_RS16565	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DSB67_RS16570	COG0840	transmembrane signaling receptor activity
DSB67_RS16580	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DSB67_RS16595	COG1612	heme a metabolic process
DSB67_RS16620	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
DSB67_RS16635	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DSB67_RS16645	COG1280	lysine exporter protein (LysE YggA)
DSB67_RS16665	COG0179	Fumarylacetoacetate (FAA) hydrolase
DSB67_RS16680	COG0697	spore germination
DSB67_RS16700	COG2814	Major facilitator Superfamily
DSB67_RS16705	COG0583	DNA-binding transcription factor activity
DSB67_RS16735	COG1120	ATPase activity
DSB67_RS16740	COG5001	Diguanylate cyclase
DSB67_RS16745	COG0739	heme binding
DSB67_RS16770	COG3314	Sporulation integral membrane protein YlbJ
DSB67_RS16785	COG0814	amino acid
DSB67_RS16820	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
DSB67_RS16825	COG1120	ATPase activity
DSB67_RS16850	COG0798	PFAM Bile acid sodium symporter
DSB67_RS16865	COG1881	PFAM PEBP family protein
DSB67_RS16880	COG2706	6-phosphogluconolactonase activity
DSB67_RS16890	COG0800	Aldolase
DSB67_RS16910	COG1131	(ABC) transporter
DSB67_RS16915	COG0842	Transport permease protein
DSB67_RS16950	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DSB67_RS16960	COG1280	lysine exporter protein (LysE YggA)
DSB67_RS16965	COG0583	DNA-binding transcription factor activity
DSB67_RS16980	COG0494	nUDIX hydrolase
DSB67_RS16995	COG1858	cytochrome C peroxidase
DSB67_RS17025	COG1505	serine-type exopeptidase activity
DSB67_RS17040	COG0589	response to stress
DSB67_RS17050	COG0584	glycerophosphoryl diester phosphodiesterase
DSB67_RS17060	COG1175	transmembrane transport
DSB67_RS17065	COG0395	ABC-type sugar transport system, permease component
DSB67_RS17070	COG3842	ATPase activity
DSB67_RS17095	COG0523	cobalamin synthesis protein
DSB67_RS17105	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DSB67_RS17115	COG4667	esterase of the alpha-beta hydrolase superfamily
DSB67_RS17120	COG1741	Belongs to the pirin family
DSB67_RS17125	COG1278	Cold shock
DSB67_RS17140	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DSB67_RS17150	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DSB67_RS17160	COG1686	Belongs to the peptidase S11 family
DSB67_RS17165	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DSB67_RS17170	COG0625	glutathione transferase activity
DSB67_RS17240	COG1764	response to oxidative stress
DSB67_RS17245	COG2084	Dehydrogenase
DSB67_RS17250	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DSB67_RS17255	COG0823	Involved in the tonB-independent uptake of proteins
DSB67_RS17270	COG1028	Short-chain dehydrogenase reductase Sdr
DSB67_RS17275	COG3483	tryptophan 2,3-dioxygenase activity
DSB67_RS17310	COG0583	DNA-binding transcription factor activity
DSB67_RS17325	COG0494	nUDIX hydrolase
DSB67_RS17425	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DSB67_RS17425	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DSB67_RS17445	COG1028	Short-chain dehydrogenase reductase Sdr
DSB67_RS17470	COG3746	phosphate-selective porin O and P
DSB67_RS17490	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DSB67_RS17530	COG0513	Belongs to the DEAD box helicase family
DSB67_RS17535	COG0583	DNA-binding transcription factor activity
DSB67_RS17560	COG1902	pentaerythritol trinitrate reductase activity
DSB67_RS17565	COG3853	Toxic anion resistance protein (TelA)
DSB67_RS17590	COG3122	Protein conserved in bacteria
DSB67_RS17595	COG2321	neutral zinc metallopeptidase
DSB67_RS17605	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DSB67_RS17610	COG1215	transferase activity, transferring glycosyl groups
DSB67_RS17620	COG0583	DNA-binding transcription factor activity
DSB67_RS17625	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DSB67_RS17635	COG2207	Transcriptional regulator
DSB67_RS17640	COG2807	transmembrane transport
DSB67_RS17650	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DSB67_RS17650	COG0574	Belongs to the PEP-utilizing enzyme family
DSB67_RS17670	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
DSB67_RS17675	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
DSB67_RS17710	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DSB67_RS17730	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DSB67_RS17745	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DSB67_RS17795	COG4948	Mandelate Racemase Muconate Lactonizing
DSB67_RS17835	COG4176	ABC-type proline glycine betaine transport system permease component
DSB67_RS17840	COG4175	Glycine betaine
DSB67_RS17840	COG3448	diguanylate cyclase activity
DSB67_RS17855	COG0583	DNA-binding transcription factor activity
DSB67_RS17865	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
DSB67_RS17900	COG1335	isochorismatase
DSB67_RS17915	COG1349	DNA-binding transcription factor activity
DSB67_RS17920	COG0346	lactoylglutathione lyase activity
DSB67_RS17925	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DSB67_RS17925	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DSB67_RS17935	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DSB67_RS17955	COG1280	lysine exporter protein (LysE YggA)
DSB67_RS17960	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DSB67_RS17975	COG0488	(ABC) transporter
DSB67_RS17980	COG0435	Glutathione S-transferase
DSB67_RS17985	COG0431	NADPH-dependent FMN reductase
DSB67_RS17990	COG0583	DNA-binding transcription factor activity
DSB67_RS18000	COG4628	conserved protein (DUF2132)
DSB67_RS18005	COG0488	(ABC) transporter
DSB67_RS18020	COG0346	lactoylglutathione lyase activity
DSB67_RS18025	COG0384	phenazine biosynthesis protein PhzF
DSB67_RS18045	COG2205	protein histidine kinase activity
DSB67_RS18050	COG0745	RESPONSE REGULATOR receiver
DSB67_RS18060	COG0454	-acetyltransferase
DSB67_RS18070	COG2814	Major facilitator Superfamily
DSB67_RS18080	COG2988	succinylglutamate desuccinylase activity
DSB67_RS18090	COG0628	permease
DSB67_RS18095	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
DSB67_RS18110	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DSB67_RS18120	COG4628	conserved protein (DUF2132)
DSB67_RS18125	COG0583	DNA-binding transcription factor activity
DSB67_RS18135	COG1686	Belongs to the peptidase S11 family
DSB67_RS18150	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DSB67_RS18175	COG0415	Belongs to the DNA photolyase family
DSB67_RS18180	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
DSB67_RS18190	COG4667	esterase of the alpha-beta hydrolase superfamily
DSB67_RS18205	COG1596	polysaccharide export
DSB67_RS18235	COG1301	dicarboxylic acid transport
DSB67_RS18240	COG3339	Conserved Protein
DSB67_RS18255	COG2207	Transcriptional regulator
DSB67_RS18270	COG0366	Alpha amylase catalytic
DSB67_RS18275	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DSB67_RS18280	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DSB67_RS18285	COG1640	4-alpha-glucanotransferase
DSB67_RS18290	COG0058	SHG alpha-glucan phosphorylase activity
DSB67_RS18315	COG1999	signal sequence binding
DSB67_RS18325	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DSB67_RS18325	COG1263	PTS System
DSB67_RS18330	COG1162	GTPase activity
DSB67_RS18335	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
DSB67_RS18355	COG0531	amino acid
DSB67_RS18360	COG1982	Orn Lys Arg decarboxylase major
DSB67_RS18380	COG2356	endonuclease I
DSB67_RS18400	COG4580	involved in the transport of maltose and maltodextrins
DSB67_RS18420	COG2814	Major facilitator Superfamily
DSB67_RS18430	COG0739	heme binding
DSB67_RS18465	COG3121	Chaperone
DSB67_RS18470	COG3188	usher protein
DSB67_RS18500	COG0612	Peptidase, M16
DSB67_RS18505	COG0840	transmembrane signaling receptor activity
DSB67_RS18525	COG1335	isochorismatase
DSB67_RS18530	COG1136	(ABC) transporter
DSB67_RS18535	COG0577	efflux transmembrane transporter activity
DSB67_RS18570	COG1764	response to oxidative stress
DSB67_RS18575	COG1846	Transcriptional regulator
DSB67_RS18585	COG3634	alkyl hydroperoxide reductase activity
DSB67_RS18600	COG2610	gluconate transmembrane transporter activity
DSB67_RS18605	COG3622	Belongs to the hyi family
DSB67_RS18610	COG0235	Class ii aldolase
DSB67_RS18615	COG3395	kinase activity
DSB67_RS18620	COG2084	Dehydrogenase
DSB67_RS18625	COG1349	DNA-binding transcription factor activity
DSB67_RS18665	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DSB67_RS18675	COG3766	membrane
DSB67_RS18685	COG0754	glutathionylspermidine amidase activity
DSB67_RS18690	COG3831	ATPase activity
DSB67_RS18695	COG0714	Associated with various cellular activities
DSB67_RS18700	COG2425	protein containing a von Willebrand factor type A (vWA) domain
DSB67_RS18705	COG3552	Protein containing von Willebrand factor type A (VWA) domain
DSB67_RS18730	COG1522	sequence-specific DNA binding
DSB67_RS18735	COG0544	peptidyl-prolyl cis-trans isomerase activity
DSB67_RS18740	COG0544	peptidyl-prolyl cis-trans isomerase activity
DSB67_RS18745	COG0544	peptidyl-prolyl cis-trans isomerase activity
DSB67_RS18760	COG2258	MOSC domain
DSB67_RS18765	COG2153	protein acetylation
DSB67_RS18775	COG0513	Belongs to the DEAD box helicase family
DSB67_RS18780	COG0667	Aldo Keto reductase
DSB67_RS18795	COG1132	(ABC) transporter
DSB67_RS18940	COG4166	transmembrane transport
DSB67_RS18970	COG1444	tRNA N-acetyltransferase activity
DSB67_RS18995	COG4608	Belongs to the ABC transporter superfamily
DSB67_RS19000	COG0444	Belongs to the ABC transporter superfamily
DSB67_RS19010	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DSB67_RS19010	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
DSB67_RS19050	COG1136	(ABC) transporter
DSB67_RS19070	COG3275	phosphorelay sensor kinase activity
DSB67_RS19075	COG3279	Response regulator of the LytR AlgR family
DSB67_RS19085	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DSB67_RS19105	COG0786	glutamate:sodium symporter activity
DSB67_RS19110	COG1028	Short-chain dehydrogenase reductase Sdr
DSB67_RS19160	COG0583	DNA-binding transcription factor activity
DSB67_RS19175	COG2897	thiosulfate sulfurtransferase activity
DSB67_RS19185	COG1131	(ABC) transporter
DSB67_RS19190	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DSB67_RS19230	COG0561	phosphatase activity
DSB67_RS19235	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
DSB67_RS19240	COG3623	hexulose-6-phosphate isomerase
DSB67_RS19275	COG2259	Doxx family
DSB67_RS19285	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
DSB67_RS19290	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DSB67_RS19410	COG4974	Belongs to the 'phage' integrase family
DSB67_RS19465	COG4580	involved in the transport of maltose and maltodextrins
DSB67_RS19470	COG1609	Transcriptional regulator
DSB67_RS19485	COG0395	ABC-type sugar transport system, permease component
DSB67_RS19490	COG2723	6-phospho-beta-galactosidase activity
DSB67_RS19495	COG3842	ATPase activity
DSB67_RS19500	COG1609	Transcriptional regulator
DSB67_RS19510	COG0564	pseudouridine synthase activity
DSB67_RS19515	COG0561	phosphatase activity
DSB67_RS19525	COG2199	diguanylate cyclase activity
DSB67_RS19535	COG3152	Membrane
DSB67_RS19550	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
DSB67_RS19565	COG0583	DNA-binding transcription factor activity
DSB67_RS19615	COG2076	Multidrug Resistance protein
DSB67_RS19625	COG1357	PFAM Pentapeptide repeats (8 copies)
DSB67_RS19630	COG3047	cAMP biosynthetic process
DSB67_RS19725	COG0668	transmembrane transport
DSB67_RS19770	COG3835	regulator
DSB67_RS19775	COG1929	Belongs to the glycerate kinase type-1 family
DSB67_RS19795	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DSB67_RS19845	COG1028	Short-chain dehydrogenase reductase Sdr
DSB67_RS19860	COG0671	phosphoesterase, PA-phosphatase related
DSB67_RS19875	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DSB67_RS19880	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DSB67_RS19885	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DSB67_RS19890	COG1116	anion transmembrane transporter activity
DSB67_RS19895	COG0351	phosphomethylpyrimidine kinase
DSB67_RS19900	COG0312	modulator of DNA gyrase
DSB67_RS19905	COG0312	modulator of DNA gyrase
DSB67_RS19910	COG1901	pseudouridine methyltransferase
DSB67_RS19970	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DSB67_RS19980	COG0584	glycerophosphoryl diester phosphodiesterase
DSB67_RS19985	COG0745	RESPONSE REGULATOR receiver
DSB67_RS20005	COG0811	peptide transport
DSB67_RS20010	COG0811	peptide transport
DSB67_RS20015	COG0848	biopolymer transport protein
DSB67_RS20060	COG0803	Belongs to the bacterial solute-binding protein 9 family
DSB67_RS20065	COG1121	(ABC) transporter
DSB67_RS20070	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DSB67_RS20085	COG1770	oligopeptidase
DSB67_RS20090	COG2814	Major facilitator Superfamily
DSB67_RS20095	COG0010	Belongs to the arginase family
DSB67_RS20100	COG1166	arginine decarboxylase activity
DSB67_RS20110	COG4067	protein conserved in archaea
DSB67_RS20110	COG0189	ligase activity
DSB67_RS20115	COG0189	ligase activity
DSB67_RS20140	COG0583	DNA-binding transcription factor activity
DSB67_RS20165	COG2723	6-phospho-beta-galactosidase activity
DSB67_RS20180	COG1114	Component of the transport system for branched-chain amino acids
DSB67_RS20200	COG0579	oxidoreductase
DSB67_RS20205	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
DSB67_RS20220	COG3033	Beta-eliminating lyase
DSB67_RS20240	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DSB67_RS20245	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DSB67_RS20280	COG3706	GGDEF domain
DSB67_RS20285	COG0415	Belongs to the DNA photolyase family
DSB67_RS20290	COG3046	protein related to deoxyribodipyrimidine photolyase
DSB67_RS20305	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DSB67_RS20305	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DSB67_RS20310	COG1765	OsmC-like protein
DSB67_RS20365	COG1011	Hydrolase
DSB67_RS20390	COG3240	lipase activity
DSB67_RS20410	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DSB67_RS20420	COG1840	ABC-type Fe3 transport system, periplasmic component
DSB67_RS20430	COG3842	ATPase activity
DSB67_RS20455	COG2990	Protein conserved in bacteria
DSB67_RS20465	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DSB67_RS20470	COG2866	Carboxypeptidase
DSB67_RS20480	COG0583	DNA-binding transcription factor activity
DSB67_RS20505	COG3104	oligopeptide transport
DSB67_RS20510	COG1760	l-serine dehydratase
DSB67_RS20535	COG1388	LysM domain
DSB67_RS20535	COG0741	lytic transglycosylase activity
DSB67_RS20555	COG1815	bacterial-type flagellum-dependent cell motility
DSB67_RS20560	COG1558	bacterial-type flagellum-dependent cell motility
DSB67_RS20565	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
DSB67_RS20570	COG1749	Flagellar hook protein flgE
DSB67_RS20575	COG4787	bacterial-type flagellum-dependent cell motility
DSB67_RS20580	COG4786	Flagellar basal body rod
DSB67_RS20585	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
DSB67_RS20590	COG1706	bacterial-type flagellum-dependent cell motility
DSB67_RS20600	COG4786	Flagellar basal body rod
DSB67_RS20600	COG1256	bacterial-type flagellum assembly
DSB67_RS20605	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DSB67_RS20665	COG0384	phenazine biosynthesis protein PhzF
DSB67_RS20675	COG1360	Flagellar Motor Protein
DSB67_RS20680	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DSB67_RS20685	COG1191	sigma factor activity
DSB67_RS20690	COG1580	Controls the rotational direction of flagella during chemotaxis
DSB67_RS20710	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
DSB67_RS20720	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DSB67_RS20735	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DSB67_RS20745	COG1987	bacterial-type flagellum assembly
DSB67_RS20845	COG0346	lactoylglutathione lyase activity
DSB67_RS20885	COG0156	8-amino-7-oxononanoate synthase activity
DSB67_RS20890	COG1063	alcohol dehydrogenase
DSB67_RS20895	COG4974	Belongs to the 'phage' integrase family
DSB67_RS21030	COG4695	Portal protein
DSB67_RS21165	COG1063	alcohol dehydrogenase
DSB67_RS21190	COG2199	diguanylate cyclase activity
DSB67_RS21190	COG2203	Gaf domain
DSB67_RS21195	COG2223	nitrite transmembrane transporter activity
DSB67_RS21200	COG1063	alcohol dehydrogenase
DSB67_RS21210	COG0668	transmembrane transport
DSB67_RS21225	COG1620	l-lactate permease
DSB67_RS21235	COG1505	serine-type exopeptidase activity
DSB67_RS21240	COG4172	Belongs to the ABC transporter superfamily
DSB67_RS21250	COG1067	ATP-dependent peptidase activity
DSB67_RS21260	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
DSB67_RS21280	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DSB67_RS21305	COG1122	ATPase activity
DSB67_RS21315	COG1566	PFAM secretion protein HlyD family protein
DSB67_RS21345	COG0813	purine-nucleoside phosphorylase activity
DSB67_RS21355	COG3272	Protein of unknown function (DUF1722)
DSB67_RS21360	COG0789	Transcriptional regulator
DSB67_RS21365	COG0415	Belongs to the DNA photolyase family
DSB67_RS21370	COG1376	ErfK ybiS ycfS ynhG family protein
DSB67_RS21370	COG1388	LysM domain
DSB67_RS21385	COG0672	)-iron permease
DSB67_RS21405	COG0513	Belongs to the DEAD box helicase family
DSB67_RS21410	COG1770	oligopeptidase
DSB67_RS21415	COG4771	TonB-dependent receptor
DSB67_RS21445	COG0573	inorganic phosphate transmembrane transporter activity
DSB67_RS21450	COG0581	inorganic phosphate transmembrane transporter activity
DSB67_RS21455	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DSB67_RS21470	COG2304	oxidoreductase activity
DSB67_RS21490	COG0714	Associated with various cellular activities
DSB67_RS21500	COG0840	transmembrane signaling receptor activity
DSB67_RS21510	COG2197	response regulator
DSB67_RS21535	COG2204	response regulator
DSB67_RS21540	COG3852	Histidine kinase
DSB67_RS21565	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
DSB67_RS21570	COG0167	dihydroorotate dehydrogenase activity
DSB67_RS21590	COG1252	NADH dehydrogenase
DSB67_RS21595	COG1301	dicarboxylic acid transport
DSB67_RS21600	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DSB67_RS21630	COG2084	Dehydrogenase
DSB67_RS21635	COG0753	catalase activity
DSB67_RS21645	COG2130	NADP-dependent
DSB67_RS21650	COG1309	transcriptional regulator
DSB67_RS21695	COG3206	protein involved in exopolysaccharide biosynthesis
DSB67_RS21695	COG0489	protein tyrosine kinase activity
DSB67_RS21710	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DSB67_RS21715	COG3842	ATPase activity
DSB67_RS21730	COG1175	transmembrane transport
DSB67_RS21735	COG3833	ABC-type maltose transport systems, permease component
DSB67_RS21765	COG2354	Protein conserved in bacteria
DSB67_RS21775	COG0401	homolog of Blt101
DSB67_RS21780	COG3217	Mosc domain protein beta barrel domain protein
DSB67_RS21780	COG0633	Ferredoxin
DSB67_RS21780	COG0633	Ferredoxin
DSB67_RS21780	COG3217	Mosc domain protein beta barrel domain protein
DSB67_RS21830	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
DSB67_RS21835	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DSB67_RS21845	COG0848	biopolymer transport protein
DSB67_RS21850	COG0811	peptide transport
DSB67_RS21855	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
DSB67_RS21865	COG3721	Heme iron utilization protein
DSB67_RS21870	COG0748	coenzyme F420 binding
DSB67_RS21880	COG0784	Response regulator, receiver
DSB67_RS21880	COG0835	chemotaxis
DSB67_RS21885	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DSB67_RS21890	COG0366	Alpha amylase catalytic
DSB67_RS21925	COG0583	DNA-binding transcription factor activity
DSB67_RS21940	COG2249	NAD(P)H dehydrogenase (quinone) activity
DSB67_RS21960	COG4977	sequence-specific DNA binding
DSB67_RS21965	COG0673	inositol 2-dehydrogenase activity
DSB67_RS21970	COG2194	sulfuric ester hydrolase activity
DSB67_RS21975	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DSB67_RS21985	COG2205	protein histidine kinase activity
DSB67_RS21990	COG0745	RESPONSE REGULATOR receiver
DSB67_RS21995	COG4221	oxidoreductase activity
DSB67_RS22010	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DSB67_RS22030	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DSB67_RS22040	COG2814	Major facilitator Superfamily
DSB67_RS22055	COG1418	mRNA catabolic process
DSB67_RS22070	COG0402	S-adenosylhomocysteine deaminase activity
DSB67_RS22075	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
DSB67_RS22080	COG2239	Acts as a magnesium transporter
DSB67_RS22085	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DSB67_RS22090	COG1566	PFAM secretion protein HlyD family protein
DSB67_RS22115	COG0745	RESPONSE REGULATOR receiver
DSB67_RS22120	COG2205	protein histidine kinase activity
DSB67_RS22130	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DSB67_RS22135	COG0531	amino acid
DSB67_RS22150	COG0583	DNA-binding transcription factor activity
DSB67_RS22175	COG0673	inositol 2-dehydrogenase activity
DSB67_RS22180	COG0534	Mate efflux family protein
DSB67_RS22255	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DSB67_RS22260	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DSB67_RS22270	COG1280	lysine exporter protein (LysE YggA)
DSB67_RS22280	COG0183	Belongs to the thiolase family
DSB67_RS22300	COG3005	denitrification pathway
DSB67_RS22320	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DSB67_RS22325	COG3850	Histidine kinase
DSB67_RS22330	COG2197	response regulator
DSB67_RS22345	COG2195	Cleaves the N-terminal amino acid of tripeptides
DSB67_RS22360	COG0840	transmembrane signaling receptor activity
DSB67_RS22370	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DSB67_RS22375	COG0545	Peptidyl-prolyl cis-trans isomerase
DSB67_RS22405	COG1278	Cold shock
DSB67_RS22410	COG3036	rescue of stalled ribosome
DSB67_RS22420	COG2199	diguanylate cyclase activity
DSB67_RS22440	COG1136	(ABC) transporter
DSB67_RS22450	COG0840	transmembrane signaling receptor activity
DSB67_RS22455	COG0783	Belongs to the Dps family
DSB67_RS22465	COG1619	proteins homologs of microcin C7 resistance protein MccF
DSB67_RS22470	COG2133	pyrroloquinoline quinone binding
DSB67_RS22475	COG1454	alcohol dehydrogenase
DSB67_RS22480	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
DSB67_RS22500	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DSB67_RS22505	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DSB67_RS22515	COG3186	Phenylalanine-4-hydroxylase
DSB67_RS22545	COG3530	Putative quorum-sensing-regulated virulence factor
DSB67_RS22570	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DSB67_RS22575	COG1845	cytochrome c oxidase, subunit III
DSB67_RS22580	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DSB67_RS22585	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DSB67_RS22595	COG0454	-acetyltransferase
DSB67_RS22635	COG0523	cobalamin synthesis protein
DSB67_RS22640	COG5001	Diguanylate cyclase
DSB67_RS22640	COG3447	MASE1 domain protein
DSB67_RS22640	COG5002	protein histidine kinase activity
DSB67_RS22645	COG0513	Belongs to the DEAD box helicase family
DSB67_RS22665	COG2200	EAL domain
DSB67_RS22670	COG1119	ATPase activity
DSB67_RS22685	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DSB67_RS22700	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
DSB67_RS22705	COG0513	Belongs to the DEAD box helicase family
DSB67_RS22720	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DSB67_RS22735	COG3278	Belongs to the heme-copper respiratory oxidase family
DSB67_RS22775	COG1024	Enoyl-CoA hydratase
DSB67_RS22780	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DSB67_RS22785	COG1960	acyl-CoA dehydrogenase activity
DSB67_RS22795	COG0183	Belongs to the thiolase family
DSB67_RS22810	COG1024	Enoyl-CoA hydratase
DSB67_RS22815	COG1024	Enoyl-CoA hydratase
DSB67_RS22825	COG1028	Short-chain dehydrogenase reductase Sdr
DSB67_RS22830	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DSB67_RS22835	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DSB67_RS22840	COG1845	cytochrome c oxidase, subunit III
DSB67_RS22845	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DSB67_RS22855	COG1902	pentaerythritol trinitrate reductase activity
DSB67_RS22855	COG0446	pyridine nucleotide-disulphide oxidoreductase
DSB67_RS22870	COG1012	belongs to the aldehyde dehydrogenase family
DSB67_RS22880	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DSB67_RS22915	COG1126	abc transporter atp-binding protein
DSB67_RS22920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DSB67_RS22925	COG4215	(ABC) transporter
DSB67_RS22930	COG4160	amino acid transport
DSB67_RS22965	COG5000	phosphorelay sensor kinase activity
DSB67_RS22965	COG5002	protein histidine kinase activity
DSB67_RS22970	COG2200	EAL domain
DSB67_RS23015	COG0443	Heat shock 70 kDa protein
DSB67_RS23045	COG1785	Belongs to the alkaline phosphatase family
DSB67_RS23090	COG0814	amino acid
DSB67_RS23150	COG0739	heme binding
DSB67_RS23205	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DSB67_RS23220	COG3335	DDE superfamily endonuclease
DSB67_RS23300	COG2814	Major facilitator Superfamily
DSB67_RS23305	COG1280	lysine exporter protein (LysE YggA)
DSB67_RS23315	COG2816	NAD+ diphosphatase activity
DSB67_RS23345	COG1132	(ABC) transporter
DSB67_RS23355	COG5640	endopeptidase activity
DSB67_RS23375	COG0583	DNA-binding transcription factor activity
DSB67_RS23410	COG1120	ATPase activity
DSB67_RS23415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DSB67_RS23420	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DSB67_RS23425	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
DSB67_RS23470	COG3005	denitrification pathway
DSB67_RS23510	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DSB67_RS23530	COG0456	acetyltransferase
DSB67_RS23530	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
DSB67_RS23595	COG0519	Catalyzes the synthesis of GMP from XMP
DSB67_RS23645	COG4774	siderophore transport
DSB67_RS23645	COG1629	transport
DSB67_RS23650	COG2382	esterase
DSB67_RS23685	COG2801	Transposase and inactivated derivatives
DSB67_RS23730	COG1028	Short-chain dehydrogenase reductase Sdr
DSB67_RS23740	COG1720	tRNA m6t6A37 methyltransferase activity
DSB67_RS23765	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DSB67_RS23780	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DSB67_RS23795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DSB67_RS23810	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
DSB67_RS23810	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DSB67_RS23810	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DSB67_RS23815	COG1105	Belongs to the carbohydrate kinase PfkB family
DSB67_RS23820	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DSB67_RS23820	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DSB67_RS23825	COG1609	Transcriptional regulator
DSB67_RS23840	COG2203	Gaf domain
DSB67_RS23840	COG2199	diguanylate cyclase activity
DSB67_RS23840	COG2200	EAL domain
DSB67_RS23845	COG0765	amino acid transport
DSB67_RS23850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DSB67_RS23855	COG0765	amino acid transport
DSB67_RS23860	COG1126	abc transporter atp-binding protein
DSB67_RS23870	COG1979	alcohol dehydrogenase
DSB67_RS23875	COG2207	Transcriptional regulator
DSB67_RS23890	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DSB67_RS23900	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DSB67_RS23920	COG0546	phosphoglycolate phosphatase activity
DSB67_RS23925	COG0840	transmembrane signaling receptor activity
DSB67_RS23935	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
DSB67_RS23940	COG0513	Belongs to the DEAD box helicase family
DSB67_RS23945	COG4943	cyclic-guanylate-specific phosphodiesterase activity
DSB67_RS23960	COG3038	cytochrome b561
DSB67_RS23970	COG2116	formate transmembrane transporter activity
DSB67_RS23980	COG0583	DNA-binding transcription factor activity
DSB67_RS23990	COG3593	DNA synthesis involved in DNA repair
DSB67_RS23995	COG0737	Belongs to the 5'-nucleotidase family
DSB67_RS24010	COG1410	methionine synthase
DSB67_RS24010	COG0646	methionine synthase
DSB67_RS24015	COG0076	glutamate decarboxylase activity
DSB67_RS24070	COG2267	carboxylic ester hydrolase activity
DSB67_RS24075	COG2067	long-chain fatty acid transport protein
DSB67_RS24085	COG0501	Belongs to the peptidase M48B family
DSB67_RS24090	COG2050	protein possibly involved in aromatic compounds catabolism
DSB67_RS24125	COG0484	heat shock protein binding
DSB67_RS24135	COG3300	MHYT domain
DSB67_RS24135	COG5001	Diguanylate cyclase
DSB67_RS24140	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DSB67_RS24150	COG4181	ATPase activity
DSB67_RS24155	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
DSB67_RS24165	COG1984	allophanate hydrolase subunit 2
DSB67_RS24170	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DSB67_RS24185	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DSB67_RS24200	COG0583	DNA-binding transcription factor activity
DSB67_RS24205	COG0045	succinate-CoA ligase (ADP-forming) activity
DSB67_RS24205	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DSB67_RS24205	COG1042	CoA-binding domain protein
DSB67_RS24225	COG0023	Translation Initiation Factor
DSB67_RS24240	COG3140	Belongs to the UPF0181 family
DSB67_RS24265	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
DSB67_RS24270	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
DSB67_RS24290	COG5001	Diguanylate cyclase
DSB67_RS24290	COG4251	negative regulation of phosphorylation
DSB67_RS24290	COG3706	GGDEF domain
DSB67_RS24290	COG2203	Gaf domain
DSB67_RS24300	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
DSB67_RS24305	COG4149	molybdate abc transporter
DSB67_RS24310	COG0725	ABC transporter, periplasmic molybdate-binding protein
DSB67_RS24320	COG3111	PFAM Bacterial OB fold (BOF) protein
DSB67_RS24345	COG0602	queuosine metabolic process
DSB67_RS24350	COG1328	CTP reductase activity
DSB67_RS24410	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DSB67_RS24415	COG3118	belongs to the thioredoxin family
DSB67_RS24450	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
DSB67_RS24465	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DSB67_RS24465	COG1648	precorrin-2 dehydrogenase activity
DSB67_RS24525	COG0277	FAD linked oxidase domain protein
DSB67_RS24530	COG0583	DNA-binding transcription factor activity
DSB67_RS24545	COG2425	protein containing a von Willebrand factor type A (vWA) domain
DSB67_RS24560	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
DSB67_RS24570	COG1288	antiporter activity
DSB67_RS24580	COG3040	lipid binding
DSB67_RS24615	COG3469	chitinase activity
DSB67_RS24625	COG0419	ATPase involved in DNA repair
DSB67_RS24630	COG0420	3'-5' exonuclease activity
DSB67_RS24660	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DSB67_RS24675	COG0840	transmembrane signaling receptor activity
DSB67_RS24700	COG2755	lipolytic protein G-D-S-L family
DSB67_RS24700	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DSB67_RS24710	COG5642	Protein of unknown function (DUF2384)
DSB67_RS24755	COG0671	phosphoesterase, PA-phosphatase related
DSB67_RS24770	COG2962	Rard protein
DSB67_RS24780	COG0835	chemotaxis
DSB67_RS24780	COG0784	Response regulator, receiver
DSB67_RS24785	COG0778	Nitroreductase
DSB67_RS24805	COG3179	chitinase
DSB67_RS24940	COG1522	sequence-specific DNA binding
DSB67_RS24975	COG0515	serine threonine protein kinase
DSB67_RS25000	COG3501	Rhs element vgr protein
DSB67_RS25015	COG2204	response regulator
DSB67_RS25065	COG0697	spore germination
DSB67_RS25070	COG0583	DNA-binding transcription factor activity
DSB67_RS25085	COG0778	Nitroreductase
DSB67_RS25180	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DSB67_RS25270	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DSB67_RS25285	COG0494	nUDIX hydrolase
DSB67_RS25295	COG0625	glutathione transferase activity
DSB67_RS25305	COG0242	peptide deformylase activity
DSB67_RS25430	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DSB67_RS25435	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DSB67_RS25440	COG1192	Involved in chromosome partitioning