locus-tag	class	description
MKR81_RS00010	COG0592	DNA-directed DNA polymerase activity
MKR81_RS00020	COG0187	DNA topoisomerase II activity
MKR81_RS00025	COG0071	Belongs to the small heat shock protein (HSP20) family
MKR81_RS00030	COG3977	Valine--pyruvate aminotransferase
MKR81_RS00045	COG2119	membrane
MKR81_RS00055	COG0425	Belongs to the sulfur carrier protein TusA family
MKR81_RS00070	COG0604	alcohol dehydrogenase
MKR81_RS00075	COG0183	Belongs to the thiolase family
MKR81_RS00085	COG1739	Uncharacterized protein family UPF0029
MKR81_RS00090	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MKR81_RS00140	COG2132	Multicopper oxidase
MKR81_RS00160	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MKR81_RS00165	COG2104	thiamine diphosphate biosynthetic process
MKR81_RS00180	COG0006	proline dipeptidase activity
MKR81_RS00180	COG0006	proline dipeptidase activity
MKR81_RS00190	COG2814	Major facilitator Superfamily
MKR81_RS00210	COG3220	belongs to the UPF0276 family
MKR81_RS00220	COG0210	DNA helicase
MKR81_RS00225	COG0405	Gamma-glutamyltransferase
MKR81_RS00230	COG1280	lysine exporter protein (LysE YggA)
MKR81_RS00250	COG2962	Rard protein
MKR81_RS00255	COG0514	ATP-dependent DNA helicase (RecQ)
MKR81_RS00265	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
MKR81_RS00280	COG3118	belongs to the thioredoxin family
MKR81_RS00295	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
MKR81_RS00300	COG0633	Ferredoxin
MKR81_RS00350	COG3071	HemY protein
MKR81_RS00355	COG2959	enzyme of heme biosynthesis
MKR81_RS00360	COG1587	Uroporphyrinogen-III synthase
MKR81_RS00370	COG3072	Adenylate cyclase
MKR81_RS00385	COG0019	diaminopimelate decarboxylase activity
MKR81_RS00405	COG1011	Hydrolase
MKR81_RS00410	COG2200	EAL domain
MKR81_RS00410	COG3287	FIST C domain
MKR81_RS00410	COG2199	diguanylate cyclase activity
MKR81_RS00415	COG3148	PFAM DTW domain containing protein
MKR81_RS00430	COG0561	phosphatase activity
MKR81_RS00435	COG2267	carboxylic ester hydrolase activity
MKR81_RS00440	COG1280	lysine exporter protein (LysE YggA)
MKR81_RS00445	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
MKR81_RS00450	COG0640	Transcriptional regulator
MKR81_RS00455	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MKR81_RS00500	COG2095	MarC family integral membrane protein
MKR81_RS00510	COG0742	ribosomal rna small subunit methyltransferase
MKR81_RS00515	COG0552	protein localization to endoplasmic reticulum
MKR81_RS00520	COG2884	Cell division ATP-binding protein ftsE
MKR81_RS00525	COG2177	Part of the ABC transporter FtsEX involved in
MKR81_RS00540	COG0705	Rhomboid family
MKR81_RS00545	COG1580	Controls the rotational direction of flagella during chemotaxis
MKR81_RS00550	COG3161	chorismate lyase activity
MKR81_RS00560	COG2937	Belongs to the GPAT DAPAT family
MKR81_RS00575	COG0534	Mate efflux family protein
MKR81_RS00580	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MKR81_RS00680	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MKR81_RS00690	COG0812	UDP-N-acetylmuramate dehydrogenase activity
MKR81_RS00730	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MKR81_RS00735	COG0250	Participates in transcription elongation, termination and antitermination
MKR81_RS00750	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MKR81_RS00770	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
MKR81_RS00775	COG2816	NAD+ diphosphatase activity
MKR81_RS00795	COG1573	uracil-dna glycosylase
MKR81_RS00805	COG3068	Protein conserved in bacteria
MKR81_RS00810	COG1253	flavin adenine dinucleotide binding
MKR81_RS00825	COG0151	Belongs to the GarS family
MKR81_RS00840	COG0789	Transcriptional regulator
MKR81_RS00845	COG3710	Transcriptional regulator
MKR81_RS00850	COG0531	amino acid
MKR81_RS00855	COG1982	Orn Lys Arg decarboxylase major
MKR81_RS00900	COG2199	diguanylate cyclase activity
MKR81_RS00905	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
MKR81_RS00910	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MKR81_RS00920	COG0439	Biotin carboxylase
MKR81_RS00925	COG0511	ligase activity, forming carbon-carbon bonds
MKR81_RS00930	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
MKR81_RS00935	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MKR81_RS00950	COG2814	Major facilitator Superfamily
MKR81_RS00955	COG2205	protein histidine kinase activity
MKR81_RS00955	COG2198	Histidine kinase
MKR81_RS00955	COG0784	Response regulator, receiver
MKR81_RS00975	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MKR81_RS00985	COG2095	MarC family integral membrane protein
MKR81_RS00995	COG4232	protein-disulfide reductase activity
MKR81_RS01000	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
MKR81_RS01005	COG1027	Aspartate ammonia-lyase
MKR81_RS01010	COG3030	protein affecting phage T7 exclusion by the F plasmid
MKR81_RS01015	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
MKR81_RS01025	COG2205	protein histidine kinase activity
MKR81_RS01030	COG0745	RESPONSE REGULATOR receiver
MKR81_RS01050	COG0534	Mate efflux family protein
MKR81_RS01075	COG1509	lysine 2,3-aminomutase activity
MKR81_RS01105	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
MKR81_RS01110	COG1053	succinate dehydrogenase
MKR81_RS01135	COG4942	peptidase
MKR81_RS01140	COG1045	serine acetyltransferase
MKR81_RS01155	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MKR81_RS01160	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
MKR81_RS01170	COG0840	transmembrane signaling receptor activity
MKR81_RS01175	COG0471	metal ion transport
MKR81_RS01185	COG1162	GTPase activity
MKR81_RS01260	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MKR81_RS01265	COG0802	atpase or kinase
MKR81_RS01270	COG0860	N-Acetylmuramoyl-L-alanine amidase
MKR81_RS01275	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MKR81_RS01290	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MKR81_RS01295	COG0330	HflC and HflK could
MKR81_RS01300	COG0330	HflC and HflK could
MKR81_RS01305	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
MKR81_RS01310	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MKR81_RS01315	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
MKR81_RS01320	COG1017	nitric oxide dioxygenase activity
MKR81_RS01320	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MKR81_RS01330	COG0557	exoribonuclease II activity
MKR81_RS01335	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MKR81_RS01340	COG0546	phosphoglycolate phosphatase activity
MKR81_RS01360	COG0512	Glutamine amidotransferase of anthranilate synthase
MKR81_RS01365	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MKR81_RS01385	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MKR81_RS01390	COG3954	Phosphoribulokinase
MKR81_RS01400	COG0429	hydrolase of the alpha beta-hydrolase fold
MKR81_RS01410	COG0488	(ABC) transporter
MKR81_RS01415	COG2249	NAD(P)H dehydrogenase (quinone) activity
MKR81_RS01430	COG1047	Peptidyl-prolyl cis-trans
MKR81_RS01435	COG1446	asparaginase
MKR81_RS01450	COG0545	Peptidyl-prolyl cis-trans isomerase
MKR81_RS01455	COG2964	Protein conserved in bacteria
MKR81_RS01460	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
MKR81_RS01465	COG2923	Belongs to the DsrF TusC family
MKR81_RS01470	COG2168	tRNA wobble position uridine thiolation
MKR81_RS01485	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MKR81_RS01495	COG2906	2 iron, 2 sulfur cluster binding
MKR81_RS01505	COG0281	malic enzyme
MKR81_RS01515	COG0626	cystathionine gamma-synthase activity
MKR81_RS01520	COG0527	aspartate kinase activity
MKR81_RS01520	COG0460	homoserine dehydrogenase
MKR81_RS01525	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
MKR81_RS01535	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
MKR81_RS01545	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MKR81_RS01560	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
MKR81_RS01560	COG0165	Argininosuccinate lyase
MKR81_RS01570	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MKR81_RS01575	COG0678	peroxiredoxin activity
MKR81_RS01575	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
MKR81_RS01585	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
MKR81_RS01630	COG0338	D12 class N6 adenine-specific DNA methyltransferase
MKR81_RS01635	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MKR81_RS01645	COG2965	DNA replication, synthesis of RNA primer
MKR81_RS01665	COG0305	Participates in initiation and elongation during chromosome replication
MKR81_RS01670	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MKR81_RS01680	COG0432	Pfam Uncharacterised protein family UPF0047
MKR81_RS01695	COG0735	belongs to the Fur family
MKR81_RS01700	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MKR81_RS01720	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
MKR81_RS01770	COG1410	methionine synthase
MKR81_RS01770	COG0646	methionine synthase
MKR81_RS01775	COG0527	aspartate kinase activity
MKR81_RS01780	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
MKR81_RS01790	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MKR81_RS01805	COG0629	single-stranded DNA binding
MKR81_RS01810	COG2200	EAL domain
MKR81_RS01810	COG2199	diguanylate cyclase activity
MKR81_RS01835	COG3409	Peptidoglycan-binding domain 1 protein
MKR81_RS01835	COG3267	Type II secretory pathway component ExeA
MKR81_RS01845	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MKR81_RS01850	COG1459	type II secretion system
MKR81_RS01860	COG2165	general secretion pathway protein
MKR81_RS01895	COG1077	Cell shape determining protein MreB Mrl
MKR81_RS01900	COG1792	Involved in formation and maintenance of cell shape
MKR81_RS01905	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
MKR81_RS01910	COG0424	maF-like protein
MKR81_RS01920	COG3164	Protein of unknown function
MKR81_RS01925	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MKR81_RS01930	COG0312	modulator of DNA gyrase
MKR81_RS01935	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
MKR81_RS01950	COG0564	pseudouridine synthase activity
MKR81_RS01955	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MKR81_RS01965	COG0312	modulator of DNA gyrase
MKR81_RS01970	COG2239	Acts as a magnesium transporter
MKR81_RS01975	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
MKR81_RS01985	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MKR81_RS01990	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
MKR81_RS02000	COG1137	ATPase activity
MKR81_RS02005	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
MKR81_RS02015	COG0517	IMP dehydrogenase activity
MKR81_RS02015	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
MKR81_RS02025	COG1127	ABC transporter
MKR81_RS02030	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MKR81_RS02035	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MKR81_RS02040	COG2854	intermembrane phospholipid transfer
MKR81_RS02050	COG5007	Belongs to the BolA IbaG family
MKR81_RS02060	COG0204	Acyl-transferase
MKR81_RS02065	COG0251	oxidation-reduction process
MKR81_RS02100	COG0456	acetyltransferase
MKR81_RS02110	COG0525	valine-tRNA ligase activity
MKR81_RS02115	COG2927	DNA polymerase III (CHI subunit)
MKR81_RS02125	COG0795	lipopolysaccharide-transporting ATPase activity
MKR81_RS02130	COG0795	lipopolysaccharide-transporting ATPase activity
MKR81_RS02140	COG1028	Short-chain dehydrogenase reductase Sdr
MKR81_RS02150	COG0726	polysaccharide deacetylase
MKR81_RS02155	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MKR81_RS02165	COG1447	Phosphotransferase system cellobiose-specific component IIA
MKR81_RS02170	COG1486	melibiose metabolic process
MKR81_RS02180	COG1609	Transcriptional regulator
MKR81_RS02185	COG3437	response regulator, receiver
MKR81_RS02230	COG1012	belongs to the aldehyde dehydrogenase family
MKR81_RS02330	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MKR81_RS02335	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MKR81_RS02350	COG0762	integral membrane protein
MKR81_RS02355	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MKR81_RS02360	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MKR81_RS02375	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MKR81_RS02380	COG1678	Uncharacterized ACR, COG1678
MKR81_RS02385	COG0189	ligase activity
MKR81_RS02390	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MKR81_RS02395	COG2356	endonuclease I
MKR81_RS02415	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
MKR81_RS02435	COG0191	fructose-bisphosphate aldolase activity
MKR81_RS02440	COG0668	transmembrane transport
MKR81_RS02455	COG0583	DNA-binding transcription factor activity
MKR81_RS02465	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MKR81_RS02475	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
MKR81_RS02485	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
MKR81_RS02495	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MKR81_RS02500	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MKR81_RS02520	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
MKR81_RS02530	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
MKR81_RS02535	COG1595	DNA-templated transcription, initiation
MKR81_RS02550	COG3086	response to oxidative stress
MKR81_RS02570	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MKR81_RS02575	COG1381	Involved in DNA repair and RecF pathway recombination
MKR81_RS02580	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
MKR81_RS02600	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MKR81_RS02605	COG3956	TIGRFAM MazG family protein
MKR81_RS02615	COG0148	phosphopyruvate hydratase activity
MKR81_RS02625	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
MKR81_RS02655	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MKR81_RS02665	COG1546	Belongs to the CinA family
MKR81_RS02670	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MKR81_RS02685	COG0527	aspartate kinase activity
MKR81_RS02745	COG3630	sodium ion export across plasma membrane
MKR81_RS02750	COG0511	ligase activity, forming carbon-carbon bonds
MKR81_RS02750	COG5016	pyruvate
MKR81_RS02755	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
MKR81_RS02765	COG1238	metal cluster binding
MKR81_RS02770	COG0612	Peptidase, M16
MKR81_RS02790	COG4536	flavin adenine dinucleotide binding
MKR81_RS02795	COG4137	Cytochrome C assembly protein
MKR81_RS02800	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MKR81_RS02805	COG0228	four-way junction DNA binding
MKR81_RS02825	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
MKR81_RS02830	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
MKR81_RS02835	COG0237	dephospho-CoA kinase activity
MKR81_RS02845	COG1459	type II secretion system
MKR81_RS02850	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MKR81_RS02875	COG2186	Transcriptional regulator
MKR81_RS02880	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
MKR81_RS02885	COG0508	dehydrogenase complex catalyzes the overall conversion of
MKR81_RS02890	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MKR81_RS02905	COG0288	reversible hydration of carbon dioxide
MKR81_RS02910	COG0659	secondary active sulfate transmembrane transporter activity
MKR81_RS02915	COG1131	(ABC) transporter
MKR81_RS02920	COG0842	Transport permease protein
MKR81_RS02925	COG1560	Kdo2-lipid A biosynthetic process
MKR81_RS02940	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MKR81_RS02950	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MKR81_RS02965	COG1643	Atp-dependent helicase
MKR81_RS02970	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MKR81_RS02975	COG1752	Esterase of the alpha-beta hydrolase superfamily
MKR81_RS02980	COG1049	propionate catabolic process, 2-methylcitrate cycle
MKR81_RS02995	COG0004	ammonium transporteR
MKR81_RS03000	COG1840	ABC-type Fe3 transport system, periplasmic component
MKR81_RS03010	COG3842	ATPase activity
MKR81_RS03015	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MKR81_RS03030	COG2971	BadF BadG BcrA BcrD
MKR81_RS03040	COG4608	Belongs to the ABC transporter superfamily
MKR81_RS03045	COG0444	Belongs to the ABC transporter superfamily
MKR81_RS03050	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MKR81_RS03060	COG0747	negative chemotaxis
MKR81_RS03065	COG0784	Response regulator, receiver
MKR81_RS03065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MKR81_RS03065	COG2198	Histidine kinase
MKR81_RS03065	COG2205	protein histidine kinase activity
MKR81_RS03075	COG0628	permease
MKR81_RS03095	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MKR81_RS03100	COG0739	heme binding
MKR81_RS03105	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MKR81_RS03115	COG2027	D-alanyl-D-alanine carboxypeptidase
MKR81_RS03120	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
MKR81_RS03125	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MKR81_RS03130	COG1534	Rna-binding protein
MKR81_RS03140	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MKR81_RS03145	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MKR81_RS03155	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MKR81_RS03175	COG0195	Participates in both transcription termination and antitermination
MKR81_RS03195	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MKR81_RS03215	COG0534	Mate efflux family protein
MKR81_RS03220	COG0826	peptidase U32
MKR81_RS03225	COG0826	peptidase U32
MKR81_RS03235	COG3154	lipid carrier protein
MKR81_RS03240	COG3153	acetyltransferase
MKR81_RS03260	COG3706	GGDEF domain
MKR81_RS03275	COG0084	hydrolase, TatD family'
MKR81_RS03280	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MKR81_RS03290	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
MKR81_RS03300	COG0813	purine-nucleoside phosphorylase activity
MKR81_RS03310	COG0560	Phosphoserine phosphatase
MKR81_RS03320	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
MKR81_RS03325	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MKR81_RS03355	COG1022	Amp-dependent synthetase and ligase
MKR81_RS03385	COG4964	Belongs to the GSP D family
MKR81_RS03445	COG0583	DNA-binding transcription factor activity
MKR81_RS03450	COG3408	Glycogen debranching enzyme
MKR81_RS03450	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
MKR81_RS03460	COG0531	amino acid
MKR81_RS03465	COG2731	YhcH YjgK YiaL family protein
MKR81_RS03470	COG3250	beta-galactosidase activity
MKR81_RS03475	COG1609	Transcriptional regulator
MKR81_RS03480	COG0768	penicillin binding
MKR81_RS03485	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MKR81_RS03490	COG1085	galactose-1-phosphate uridylyltransferase
MKR81_RS03500	COG2017	converts alpha-aldose to the beta-anomer
MKR81_RS03505	COG1609	Transcriptional regulator
MKR81_RS03520	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MKR81_RS03540	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
MKR81_RS03545	COG1349	DNA-binding transcription factor activity
MKR81_RS03555	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MKR81_RS03560	COG2271	Major facilitator Superfamily
MKR81_RS03565	COG0584	glycerophosphoryl diester phosphodiesterase
MKR81_RS03580	COG2171	N-acyltransferase activity
MKR81_RS03595	COG3141	response to X-ray
MKR81_RS03615	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
MKR81_RS03620	COG1074	ATP-dependent DNA helicase activity
MKR81_RS03625	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MKR81_RS03645	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MKR81_RS03645	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
MKR81_RS03655	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
MKR81_RS03660	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
MKR81_RS03665	COG2166	iron-sulfur cluster assembly
MKR81_RS03670	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MKR81_RS03675	COG0693	protein deglycase activity
MKR81_RS03680	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MKR81_RS03700	COG1595	DNA-templated transcription, initiation
MKR81_RS03730	COG0271	Belongs to the BolA IbaG family
MKR81_RS03765	COG1477	protein flavinylation
MKR81_RS03780	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MKR81_RS03785	COG0514	ATP-dependent DNA helicase (RecQ)
MKR81_RS03805	COG0733	neurotransmitter:sodium symporter activity
MKR81_RS03830	COG1720	tRNA m6t6A37 methyltransferase activity
MKR81_RS03845	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
MKR81_RS03875	COG3098	single-species biofilm formation
MKR81_RS03880	COG0564	pseudouridine synthase activity
MKR81_RS03895	COG0024	Methionine aminopeptidase
MKR81_RS03920	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MKR81_RS03925	COG0575	Belongs to the CDS family
MKR81_RS03935	COG0750	zinc metalloprotease
MKR81_RS03945	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
MKR81_RS03950	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MKR81_RS03975	COG0587	DNA-directed DNA polymerase activity
MKR81_RS03995	COG0347	Belongs to the P(II) protein family
MKR81_RS04010	COG1388	LysM domain
MKR81_RS04010	COG0741	lytic transglycosylase activity
MKR81_RS04020	COG2226	methyltransferase
MKR81_RS04030	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MKR81_RS04055	COG1960	acyl-CoA dehydrogenase activity
MKR81_RS04060	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
MKR81_RS04065	COG0121	glutamine amidotransferase
MKR81_RS04070	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MKR81_RS04075	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MKR81_RS04080	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
MKR81_RS04085	COG2233	PERMEase
MKR81_RS04105	COG1393	Belongs to the ArsC family
MKR81_RS04110	COG4783	chaperone-mediated protein folding
MKR81_RS04125	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MKR81_RS04130	COG2716	regulation of RNA biosynthetic process
MKR81_RS04135	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MKR81_RS04140	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
MKR81_RS04160	COG1393	Belongs to the ArsC family
MKR81_RS04185	COG2837	iron assimilation
MKR81_RS04190	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MKR81_RS04195	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MKR81_RS04200	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MKR81_RS04205	COG1334	flagellar protein FlaG
MKR81_RS04210	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
MKR81_RS04220	COG1516	flagellar protein fliS
MKR81_RS04240	COG1677	Flagellar hook-basal body complex protein FliE
MKR81_RS04250	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MKR81_RS04305	COG1987	bacterial-type flagellum assembly
MKR81_RS04310	COG1684	flagellar biosynthetic protein fliR
MKR81_RS04345	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
MKR81_RS04350	COG2198	Histidine kinase
MKR81_RS04350	COG0784	Response regulator, receiver
MKR81_RS04350	COG0643	Histidine kinase
MKR81_RS04355	COG2201	protein-glutamate methylesterase activity
MKR81_RS04360	COG1192	Involved in chromosome partitioning
MKR81_RS04370	COG0835	chemotaxis
MKR81_RS04380	COG4133	protoheme IX ABC transporter activity
MKR81_RS04385	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MKR81_RS04390	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MKR81_RS04405	COG1138	Cytochrome C-type biogenesis protein
MKR81_RS04410	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MKR81_RS04420	COG3088	subunit of a heme lyase
MKR81_RS04420	COG4235	cytochrome complex assembly
MKR81_RS04425	COG2853	Lipoprotein
MKR81_RS04430	COG2067	long-chain fatty acid transport protein
MKR81_RS04450	COG0183	Belongs to the thiolase family
MKR81_RS04470	COG2062	phosphohistidine phosphatase, SixA
MKR81_RS04480	COG2890	protein-(glutamine-N5) methyltransferase activity
MKR81_RS04490	COG2860	membrane
MKR81_RS04495	COG3101	peptidyl-lysine hydroxylation
MKR81_RS04515	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MKR81_RS04520	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MKR81_RS04525	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MKR81_RS04545	COG0285	dihydrofolate synthase activity
MKR81_RS04550	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
MKR81_RS04555	COG1286	toxin biosynthetic process
MKR81_RS04560	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
MKR81_RS04565	COG0583	DNA-binding transcription factor activity
MKR81_RS04570	COG0745	RESPONSE REGULATOR receiver
MKR81_RS04575	COG2832	Protein of unknown function (DUF454)
MKR81_RS04585	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MKR81_RS04595	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
MKR81_RS04600	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MKR81_RS04605	COG0814	amino acid
MKR81_RS04610	COG0251	oxidation-reduction process
MKR81_RS04620	COG2964	Protein conserved in bacteria
MKR81_RS04630	COG2983	Belongs to the UPF0260 family
MKR81_RS04635	COG2261	transglycosylase associated protein
MKR81_RS04640	COG2985	domain, Protein
MKR81_RS04645	COG0076	glutamate decarboxylase activity
MKR81_RS04650	COG0668	transmembrane transport
MKR81_RS04660	COG0346	lactoylglutathione lyase activity
MKR81_RS04670	COG1785	Belongs to the alkaline phosphatase family
MKR81_RS04690	COG2226	methyltransferase
MKR81_RS04710	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MKR81_RS04715	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MKR81_RS04725	COG3139	Protein of unknown function (DUF1315)
MKR81_RS04730	COG0252	asparaginase activity
MKR81_RS04735	COG0616	signal peptide processing
MKR81_RS04740	COG0446	pyridine nucleotide-disulphide oxidoreductase
MKR81_RS04740	COG1902	pentaerythritol trinitrate reductase activity
MKR81_RS04745	COG0778	Nitroreductase
MKR81_RS04750	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MKR81_RS04765	COG0123	including yeast histone deacetylase and acetoin utilization protein
MKR81_RS04775	COG4269	membrane
MKR81_RS04790	COG3083	sulfuric ester hydrolase activity
MKR81_RS04815	COG1757	Na H antiporter
MKR81_RS04820	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MKR81_RS04825	COG2165	general secretion pathway protein
MKR81_RS04830	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MKR81_RS04835	COG2095	MarC family integral membrane protein
MKR81_RS04840	COG1012	belongs to the aldehyde dehydrogenase family
MKR81_RS04840	COG1454	alcohol dehydrogenase
MKR81_RS04860	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
MKR81_RS04865	COG4974	Belongs to the 'phage' integrase family
MKR81_RS04890	COG1403	HNH endonuclease
MKR81_RS04980	COG2003	Belongs to the UPF0758 family
MKR81_RS05040	COG1278	Cold shock
MKR81_RS05065	COG3457	Alanine racemase
MKR81_RS05075	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MKR81_RS05105	COG3504	Conjugal transfer protein
MKR81_RS05110	COG3736	Type IV secretory pathway, component VirB8
MKR81_RS05135	COG3451	type IV secretory pathway VirB4
MKR81_RS05175	COG2056	Na+-H+ antiporter family
MKR81_RS05185	COG2885	chlorophyll binding
MKR81_RS05195	COG0346	lactoylglutathione lyase activity
MKR81_RS05215	COG1566	PFAM secretion protein HlyD family protein
MKR81_RS05240	COG2205	protein histidine kinase activity
MKR81_RS05240	COG0784	Response regulator, receiver
MKR81_RS05250	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MKR81_RS05280	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MKR81_RS05285	COG4660	Part of a membrane complex involved in electron transport
MKR81_RS05290	COG4659	FMN binding
MKR81_RS05295	COG4658	electron transport chain
MKR81_RS05300	COG4656	Part of a membrane complex involved in electron transport
MKR81_RS05310	COG4657	Part of a membrane complex involved in electron transport
MKR81_RS05355	COG0556	nucleotide-excision repair
MKR81_RS05370	COG0391	Required for morphogenesis under gluconeogenic growth conditions
MKR81_RS05375	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MKR81_RS05380	COG0521	Mo-molybdopterin cofactor biosynthetic process
MKR81_RS05390	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
MKR81_RS05395	COG0314	molybdopterin synthase activity
MKR81_RS05405	COG0601	transmembrane transport
MKR81_RS05410	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MKR81_RS05415	COG0444	Belongs to the ABC transporter superfamily
MKR81_RS05425	COG0435	Glutathione S-transferase
MKR81_RS05430	COG3174	membrane
MKR81_RS05435	COG0280	phosphate acetyltransferase
MKR81_RS05435	COG0857	belongs to the CobB CobQ family
MKR81_RS05455	COG4120	Belongs to the binding-protein-dependent transport system permease family
MKR81_RS05460	COG1122	ATPase activity
MKR81_RS05465	COG0366	Alpha amylase catalytic
MKR81_RS05475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MKR81_RS05480	COG0653	protein targeting
MKR81_RS05485	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
MKR81_RS05495	COG2186	Transcriptional regulator
MKR81_RS05525	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
MKR81_RS05530	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MKR81_RS05535	COG0659	secondary active sulfate transmembrane transporter activity
MKR81_RS05540	COG1530	ribonuclease E activity
MKR81_RS05545	COG0564	pseudouridine synthase activity
MKR81_RS05550	COG0424	maF-like protein
MKR81_RS05555	COG1399	metal-binding, possibly nucleic acid-binding protein
MKR81_RS05570	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MKR81_RS05600	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MKR81_RS05615	COG0084	hydrolase, TatD family'
MKR81_RS05620	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MKR81_RS05620	COG1263	PTS System
MKR81_RS05635	COG0733	neurotransmitter:sodium symporter activity
MKR81_RS05650	COG4667	esterase of the alpha-beta hydrolase superfamily
MKR81_RS05675	COG2272	Belongs to the type-B carboxylesterase lipase family
MKR81_RS05680	COG3710	Transcriptional regulator
MKR81_RS05695	COG1940	carbohydrate kinase activity
MKR81_RS05700	COG0835	chemotaxis
MKR81_RS05700	COG0784	Response regulator, receiver
MKR81_RS05720	COG1028	Short-chain dehydrogenase reductase Sdr
MKR81_RS05725	COG0616	signal peptide processing
MKR81_RS05735	COG0539	negative regulation of cytoplasmic translation
MKR81_RS05745	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
MKR81_RS05750	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
MKR81_RS05760	COG4166	transmembrane transport
MKR81_RS05780	COG3009	Protein conserved in bacteria
MKR81_RS05790	COG2995	paraquat-inducible protein a
MKR81_RS05795	COG1609	Transcriptional regulator
MKR81_RS05800	COG3250	beta-galactosidase activity
MKR81_RS05810	COG4580	involved in the transport of maltose and maltodextrins
MKR81_RS05820	COG2211	Major facilitator Superfamily
MKR81_RS05825	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
MKR81_RS05840	COG4232	protein-disulfide reductase activity
MKR81_RS05845	COG3118	belongs to the thioredoxin family
MKR81_RS05890	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MKR81_RS05910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MKR81_RS05920	COG0577	efflux transmembrane transporter activity
MKR81_RS05925	COG1136	(ABC) transporter
MKR81_RS05925	COG0577	efflux transmembrane transporter activity
MKR81_RS05930	COG0577	efflux transmembrane transporter activity
MKR81_RS05930	COG1136	(ABC) transporter
MKR81_RS05945	COG2176	DNA-directed DNA polymerase activity
MKR81_RS06020	COG5002	protein histidine kinase activity
MKR81_RS06020	COG3850	Histidine kinase
MKR81_RS06025	COG0745	RESPONSE REGULATOR receiver
MKR81_RS06030	COG0463	Glycosyl transferase, family 2
MKR81_RS06035	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
MKR81_RS06045	COG0840	transmembrane signaling receptor activity
MKR81_RS06070	COG2175	clavaminate synthase activity
MKR81_RS06080	COG2964	Protein conserved in bacteria
MKR81_RS06085	COG0251	oxidation-reduction process
MKR81_RS06095	COG0446	pyridine nucleotide-disulphide oxidoreductase
MKR81_RS06105	COG1032	radical SAM domain protein
MKR81_RS06110	COG5001	Diguanylate cyclase
MKR81_RS06110	COG1716	ATPase activity
MKR81_RS06140	COG2350	Protein conserved in bacteria
MKR81_RS06170	COG1301	dicarboxylic acid transport
MKR81_RS06175	COG0159	tryptophan synthase activity
MKR81_RS06185	COG0134	indole-3-glycerol-phosphate synthase activity
MKR81_RS06185	COG0135	phosphoribosylanthranilate isomerase activity
MKR81_RS06195	COG0512	Glutamine amidotransferase of anthranilate synthase
MKR81_RS06200	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MKR81_RS06210	COG0613	PHP domain protein
MKR81_RS06215	COG0009	L-threonylcarbamoyladenylate synthase
MKR81_RS06225	COG1187	pseudouridine synthase activity
MKR81_RS06245	COG0417	DNA replication proofreading
MKR81_RS06250	COG2197	response regulator
MKR81_RS06255	COG0322	excinuclease ABC activity
MKR81_RS06295	COG0019	diaminopimelate decarboxylase activity
MKR81_RS06310	COG1058	Belongs to the CinA family
MKR81_RS06310	COG1546	Belongs to the CinA family
MKR81_RS06320	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MKR81_RS06325	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MKR81_RS06350	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
MKR81_RS06360	COG0437	4 iron, 4 sulfur cluster binding
MKR81_RS06365	COG3301	Polysulphide reductase, NrfD
MKR81_RS06370	COG1138	Cytochrome C-type biogenesis protein
MKR81_RS06380	COG4235	cytochrome complex assembly
MKR81_RS06380	COG3088	subunit of a heme lyase
MKR81_RS06415	COG2989	Protein conserved in bacteria
MKR81_RS06420	COG3108	Peptidase M15
MKR81_RS06425	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MKR81_RS06440	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
MKR81_RS06465	COG1846	Transcriptional regulator
MKR81_RS06470	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MKR81_RS06475	COG0840	transmembrane signaling receptor activity
MKR81_RS06495	COG1448	Aminotransferase
MKR81_RS06515	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MKR81_RS06530	COG0017	Asparaginyl-tRNA synthetase
MKR81_RS06540	COG0720	synthase
MKR81_RS06545	COG2197	response regulator
MKR81_RS06565	COG1760	l-serine dehydratase
MKR81_RS06570	COG0814	amino acid
MKR81_RS06590	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MKR81_RS06605	COG3106	COG3106 Predicted ATPase
MKR81_RS06620	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MKR81_RS06770	COG0494	nUDIX hydrolase
MKR81_RS07040	COG1683	Conserved Protein
MKR81_RS07135	COG4221	oxidoreductase activity
MKR81_RS07150	COG3340	Belongs to the peptidase S51 family
MKR81_RS07165	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MKR81_RS07180	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MKR81_RS07180	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
MKR81_RS07190	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MKR81_RS07195	COG1609	Transcriptional regulator
MKR81_RS07205	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MKR81_RS07220	COG0596	Alpha beta hydrolase
MKR81_RS07240	COG0471	metal ion transport
MKR81_RS07245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MKR81_RS07245	COG4191	Histidine kinase
MKR81_RS07265	COG1280	lysine exporter protein (LysE YggA)
MKR81_RS07270	COG1328	CTP reductase activity
MKR81_RS07275	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
MKR81_RS07285	COG0861	Integral membrane protein TerC family
MKR81_RS07295	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
MKR81_RS07305	COG1454	alcohol dehydrogenase
MKR81_RS07310	COG0814	amino acid
MKR81_RS07330	COG1132	(ABC) transporter
MKR81_RS07335	COG1132	(ABC) transporter
MKR81_RS07340	COG2165	general secretion pathway protein
MKR81_RS07345	COG0583	DNA-binding transcription factor activity
MKR81_RS07355	COG0673	inositol 2-dehydrogenase activity
MKR81_RS07370	COG0443	Heat shock 70 kDa protein
MKR81_RS07375	COG0443	Heat shock 70 kDa protein
MKR81_RS07415	COG3227	Zinc metalloprotease (Elastase)
MKR81_RS07425	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
MKR81_RS07430	COG1643	Atp-dependent helicase
MKR81_RS07455	COG3063	Type IV pilus biogenesis stability protein PilW
MKR81_RS07485	COG0531	amino acid
MKR81_RS07490	COG1280	lysine exporter protein (LysE YggA)
MKR81_RS07500	COG0702	epimerase
MKR81_RS07505	COG1560	Kdo2-lipid A biosynthetic process
MKR81_RS07525	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
MKR81_RS07530	COG1280	lysine exporter protein (LysE YggA)
MKR81_RS07565	COG1115	amino acid carrier protein
MKR81_RS07590	COG1368	sulfuric ester hydrolase activity
MKR81_RS07605	COG0215	cysteine-tRNA ligase activity
MKR81_RS07610	COG0534	Mate efflux family protein
MKR81_RS07615	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
MKR81_RS07625	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MKR81_RS07630	COG1858	cytochrome C peroxidase
MKR81_RS07635	COG1404	Belongs to the peptidase S8 family
MKR81_RS07640	COG3227	Zinc metalloprotease (Elastase)
MKR81_RS07655	COG0583	DNA-binding transcription factor activity
MKR81_RS07660	COG0702	epimerase
MKR81_RS07665	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
MKR81_RS07670	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MKR81_RS07675	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
MKR81_RS07700	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MKR81_RS07705	COG0667	Aldo Keto reductase
MKR81_RS07720	COG0583	DNA-binding transcription factor activity
MKR81_RS07725	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MKR81_RS07730	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
MKR81_RS07735	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MKR81_RS07740	COG0679	Auxin Efflux Carrier
MKR81_RS07780	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MKR81_RS07785	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
MKR81_RS07820	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MKR81_RS07840	COG3290	protein histidine kinase activity
MKR81_RS07845	COG4565	transcriptional regulatory protein
MKR81_RS07850	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MKR81_RS07855	COG0363	glucosamine-6-phosphate deaminase activity
MKR81_RS07860	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
MKR81_RS07895	COG3284	Transcriptional regulator
MKR81_RS07900	COG1012	belongs to the aldehyde dehydrogenase family
MKR81_RS07905	COG2358	TRAP transporter, solute receptor (TAXI family
MKR81_RS07910	COG0840	transmembrane signaling receptor activity
MKR81_RS07915	COG0730	response to heat
MKR81_RS07945	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
MKR81_RS07950	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
MKR81_RS08060	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
MKR81_RS08065	COG0372	Belongs to the citrate synthase family
MKR81_RS08075	COG2828	Protein conserved in bacteria
MKR81_RS08110	COG0561	phosphatase activity
MKR81_RS08115	COG0602	queuosine metabolic process
MKR81_RS08125	COG3706	GGDEF domain
MKR81_RS08175	COG0840	transmembrane signaling receptor activity
MKR81_RS08180	COG1254	Belongs to the acylphosphatase family
MKR81_RS08185	COG2920	part of a sulfur-relay system
MKR81_RS08195	COG0670	Belongs to the BI1 family
MKR81_RS08200	COG1126	abc transporter atp-binding protein
MKR81_RS08205	COG0765	amino acid transport
MKR81_RS08210	COG4597	amino acid ABC transporter
MKR81_RS08215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MKR81_RS08230	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
MKR81_RS08255	COG3008	intermembrane lipid transfer
MKR81_RS08260	COG2995	paraquat-inducible protein a
MKR81_RS08265	COG1132	(ABC) transporter
MKR81_RS08270	COG1956	GAF domain-containing protein
MKR81_RS08275	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
MKR81_RS08290	COG0308	aminopeptidase N
MKR81_RS08300	COG2902	Dehydrogenase
MKR81_RS08325	COG0488	(ABC) transporter
MKR81_RS08345	COG1067	ATP-dependent peptidase activity
MKR81_RS08390	COG3278	Belongs to the heme-copper respiratory oxidase family
MKR81_RS08405	COG2010	Cytochrome c
MKR81_RS08415	COG2217	Heavy metal translocating P-type atpase
MKR81_RS08430	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MKR81_RS08435	COG0589	response to stress
MKR81_RS08460	COG3842	ATPase activity
MKR81_RS08470	COG1177	transmembrane transport
MKR81_RS08480	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
MKR81_RS08485	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
MKR81_RS08505	COG0437	4 iron, 4 sulfur cluster binding
MKR81_RS08510	COG3383	formate dehydrogenase (NAD+) activity
MKR81_RS08510	COG0243	molybdopterin cofactor binding
MKR81_RS08520	COG3381	protein complex oligomerization
MKR81_RS08540	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
MKR81_RS08545	COG2194	sulfuric ester hydrolase activity
MKR81_RS08550	COG0584	glycerophosphoryl diester phosphodiesterase
MKR81_RS08555	COG0488	(ABC) transporter
MKR81_RS08570	COG4191	Histidine kinase
MKR81_RS08575	COG2204	response regulator
MKR81_RS08585	COG4662	Binding-protein-dependent transport system inner membrane component
MKR81_RS08590	COG3842	ATPase activity
MKR81_RS08600	COG0303	'Molybdopterin
MKR81_RS08610	COG1940	carbohydrate kinase activity
MKR81_RS08615	COG3148	PFAM DTW domain containing protein
MKR81_RS08660	COG0840	transmembrane signaling receptor activity
MKR81_RS08660	COG3290	protein histidine kinase activity
MKR81_RS08665	COG0791	NLP P60 protein
MKR81_RS08675	COG3706	GGDEF domain
MKR81_RS08680	COG2201	protein-glutamate methylesterase activity
MKR81_RS08695	COG0307	riboflavin synthase, alpha
MKR81_RS08700	COG0534	Mate efflux family protein
MKR81_RS08710	COG1793	dna ligase
MKR81_RS08720	COG2885	chlorophyll binding
MKR81_RS08740	COG2204	response regulator
MKR81_RS08745	COG0438	transferase activity, transferring glycosyl groups
MKR81_RS08750	COG0438	transferase activity, transferring glycosyl groups
MKR81_RS08780	COG0438	transferase activity, transferring glycosyl groups
MKR81_RS08785	COG1215	transferase activity, transferring glycosyl groups
MKR81_RS08790	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MKR81_RS08800	COG3064	Membrane
MKR81_RS08825	COG5001	Diguanylate cyclase
MKR81_RS08825	COG3300	MHYT domain
MKR81_RS08830	COG3437	response regulator, receiver
MKR81_RS08830	COG3850	Histidine kinase
MKR81_RS08830	COG2205	protein histidine kinase activity
MKR81_RS08830	COG4999	Histidine kinase
MKR81_RS08850	COG0110	maltose O-acetyltransferase activity
MKR81_RS08875	COG1846	Transcriptional regulator
MKR81_RS08890	COG3247	response to pH
MKR81_RS08895	COG0668	transmembrane transport
MKR81_RS08905	COG1404	Belongs to the peptidase S8 family
MKR81_RS08935	COG0745	RESPONSE REGULATOR receiver
MKR81_RS08985	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
MKR81_RS08985	COG2199	diguanylate cyclase activity
MKR81_RS09000	COG0668	transmembrane transport
MKR81_RS09025	COG0625	glutathione transferase activity
MKR81_RS09035	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
MKR81_RS09050	COG2195	Cleaves the N-terminal amino acid of tripeptides
MKR81_RS09060	COG0601	transmembrane transport
MKR81_RS09065	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MKR81_RS09070	COG0444	Belongs to the ABC transporter superfamily
MKR81_RS09105	COG0813	purine-nucleoside phosphorylase activity
MKR81_RS09130	COG1451	nucleotide metabolic process
MKR81_RS09135	COG5492	domain, Protein
MKR81_RS09135	COG4932	domain protein
MKR81_RS09150	COG0745	RESPONSE REGULATOR receiver
MKR81_RS09160	COG2198	Histidine kinase
MKR81_RS09160	COG2205	protein histidine kinase activity
MKR81_RS09160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MKR81_RS09160	COG0784	Response regulator, receiver
MKR81_RS09225	COG2165	general secretion pathway protein
MKR81_RS09250	COG0583	DNA-binding transcription factor activity
MKR81_RS09285	COG4139	cobalamin transport
MKR81_RS09310	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
MKR81_RS09320	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MKR81_RS09325	COG0702	epimerase
MKR81_RS09330	COG1823	symporter activity
MKR81_RS09340	COG2925	Exonuclease
MKR81_RS09350	COG1346	cytolysis
MKR81_RS09410	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MKR81_RS09415	COG4605	iron ion homeostasis
MKR81_RS09420	COG4607	ABC-type enterochelin transport system periplasmic component
MKR81_RS09425	COG4774	siderophore transport
MKR81_RS09445	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MKR81_RS09460	COG1132	(ABC) transporter
MKR81_RS09465	COG1535	isochorismatase
MKR81_RS09465	COG3433	isochorismatase activity
MKR81_RS09470	COG0072	phenylalanine-tRNA ligase activity
MKR81_RS09470	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MKR81_RS09480	COG3706	GGDEF domain
MKR81_RS09520	COG0251	oxidation-reduction process
MKR81_RS09560	COG2188	Transcriptional regulator
MKR81_RS09570	COG0010	Belongs to the arginase family
MKR81_RS09580	COG2986	histidine ammonia-lyase
MKR81_RS09625	COG0277	FAD linked oxidase domain protein
MKR81_RS09625	COG0247	lactate metabolic process
MKR81_RS09685	COG1643	Atp-dependent helicase
MKR81_RS09695	COG2949	membrane
MKR81_RS09700	COG0471	metal ion transport
MKR81_RS09705	COG3706	GGDEF domain
MKR81_RS09725	COG0492	ferredoxin-NADP+ reductase activity
MKR81_RS09730	COG4988	ABC transporter
MKR81_RS09735	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
MKR81_RS09745	COG0583	DNA-binding transcription factor activity
MKR81_RS09750	COG2200	EAL domain
MKR81_RS09780	COG5001	Diguanylate cyclase
MKR81_RS09790	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
MKR81_RS09800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MKR81_RS09800	COG4191	Histidine kinase
MKR81_RS09815	COG3070	regulator of competence-specific genes
MKR81_RS09825	COG2431	L-lysine efflux transmembrane transporter activity
MKR81_RS09835	COG0076	glutamate decarboxylase activity
MKR81_RS09850	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
MKR81_RS09860	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
MKR81_RS09895	COG0534	Mate efflux family protein
MKR81_RS09900	COG0702	epimerase
MKR81_RS09905	COG4667	esterase of the alpha-beta hydrolase superfamily
MKR81_RS09915	COG2814	Major facilitator Superfamily
MKR81_RS09920	COG1187	pseudouridine synthase activity
MKR81_RS09925	COG1061	Type III restriction enzyme res subunit
MKR81_RS09930	COG3706	GGDEF domain
MKR81_RS09985	COG3313	Fe-S protein
MKR81_RS09995	COG0659	secondary active sulfate transmembrane transporter activity
MKR81_RS10020	COG0493	'glutamate synthase
MKR81_RS10030	COG0398	Pfam SNARE associated Golgi protein
MKR81_RS10035	COG4134	Bacterial extracellular solute-binding protein
MKR81_RS10040	COG4135	transport system, permease component
MKR81_RS10045	COG4136	ATPase activity
MKR81_RS10050	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MKR81_RS10060	COG2814	Major facilitator Superfamily
MKR81_RS10065	COG3604	Transcriptional regulator
MKR81_RS10070	COG1151	hydroxylamine reductase activity
MKR81_RS10075	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MKR81_RS10085	COG0564	pseudouridine synthase activity
MKR81_RS10095	COG0733	neurotransmitter:sodium symporter activity
MKR81_RS10105	COG0626	cystathionine gamma-synthase activity
MKR81_RS10110	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
MKR81_RS10130	COG2818	Glycosylase
MKR81_RS10140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MKR81_RS10150	COG1983	PspC domain protein
MKR81_RS10160	COG1842	Phage shock protein A
MKR81_RS10165	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
MKR81_RS10175	COG4168	peptide transport system, permease
MKR81_RS10180	COG4171	peptide transport system, permease
MKR81_RS10190	COG4172	Belongs to the ABC transporter superfamily
MKR81_RS10200	COG1227	inorganic diphosphatase activity
MKR81_RS10215	COG0243	molybdopterin cofactor binding
MKR81_RS10220	COG3005	denitrification pathway
MKR81_RS10225	COG4459	periplasmic nitrate reductase
MKR81_RS10230	COG0390	transport system, permease component
MKR81_RS10240	COG2116	formate transmembrane transporter activity
MKR81_RS10265	COG1434	Gram-negative-bacterium-type cell wall biogenesis
MKR81_RS10270	COG1435	thymidine kinase activity
MKR81_RS10275	COG0215	cysteine-tRNA ligase activity
MKR81_RS10280	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MKR81_RS10285	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
MKR81_RS10290	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
MKR81_RS10295	COG3012	SEC-C Motif Domain Protein
MKR81_RS10300	COG0140	phosphoribosyl-ATP diphosphatase activity
MKR81_RS10300	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MKR81_RS10310	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MKR81_RS10315	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MKR81_RS10320	COG0131	Imidazoleglycerol-phosphate dehydratase
MKR81_RS10320	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
MKR81_RS10330	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MKR81_RS10345	COG1757	Na H antiporter
MKR81_RS10355	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MKR81_RS10375	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MKR81_RS10395	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MKR81_RS10410	COG0300	oxidoreductase activity
MKR81_RS10435	COG2226	methyltransferase
MKR81_RS10455	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
MKR81_RS10475	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MKR81_RS10485	COG1674	ftsk spoiiie
MKR81_RS10495	COG0686	Belongs to the AlaDH PNT family
MKR81_RS10505	COG0583	DNA-binding transcription factor activity
MKR81_RS10530	COG0402	S-adenosylhomocysteine deaminase activity
MKR81_RS10535	COG4934	collagen metabolic process
MKR81_RS10540	COG0270	DNA (cytosine-5-)-methyltransferase activity
MKR81_RS10550	COG3568	Endonuclease Exonuclease Phosphatase
MKR81_RS10570	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
MKR81_RS10585	COG1288	antiporter activity
MKR81_RS10595	COG2186	Transcriptional regulator
MKR81_RS10605	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MKR81_RS10610	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MKR81_RS10630	COG2824	Alkylphosphonate utilization operon protein PhnA
MKR81_RS10650	COG3119	arylsulfatase activity
MKR81_RS10680	COG0457	Tetratricopeptide repeat
MKR81_RS10750	COG4790	Type iii secretion
MKR81_RS10755	COG4794	Type iii secretion
MKR81_RS10760	COG4791	protein targeting
MKR81_RS10765	COG4792	protein secretion
MKR81_RS10780	COG3177	Filamentation induced by cAMP protein fic
MKR81_RS10810	COG4669	(LipO)protein
MKR81_RS10915	COG2205	protein histidine kinase activity
MKR81_RS10915	COG0784	Response regulator, receiver
MKR81_RS10925	COG0754	glutathionylspermidine amidase activity
MKR81_RS10935	COG3766	membrane
MKR81_RS10950	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
MKR81_RS10955	COG2885	chlorophyll binding
MKR81_RS10960	COG0823	Involved in the tonB-independent uptake of proteins
MKR81_RS10975	COG0811	peptide transport
MKR81_RS10980	COG0824	Thioesterase
MKR81_RS10990	COG4890	Cyd operon protein YbgT
MKR81_RS10995	COG1294	oxidase, subunit
MKR81_RS11000	COG1271	oxidase subunit
MKR81_RS11010	COG0632	four-way junction helicase activity
MKR81_RS11015	COG0840	transmembrane signaling receptor activity
MKR81_RS11030	COG1801	Protein of unknown function DUF72
MKR81_RS11045	COG0189	ligase activity
MKR81_RS11045	COG4067	protein conserved in archaea
MKR81_RS11070	COG0318	PFAM AMP-dependent synthetase and ligase
MKR81_RS11085	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
MKR81_RS11090	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
MKR81_RS11100	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MKR81_RS11105	COG1434	Gram-negative-bacterium-type cell wall biogenesis
MKR81_RS11110	COG0745	RESPONSE REGULATOR receiver
MKR81_RS11125	COG3070	regulator of competence-specific genes
MKR81_RS11145	COG0297	glycogen (starch) synthase activity
MKR81_RS11150	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MKR81_RS11155	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MKR81_RS11185	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MKR81_RS11190	COG0542	response to heat
MKR81_RS11200	COG1278	Cold shock
MKR81_RS11210	COG1187	pseudouridine synthase activity
MKR81_RS11215	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
MKR81_RS11225	COG1199	ATP-dependent helicase activity
MKR81_RS11230	COG0730	response to heat
MKR81_RS11235	COG3923	Primosomal replication protein n
MKR81_RS11245	COG0708	Exodeoxyribonuclease III
MKR81_RS11280	COG1882	Formate acetyltransferase
MKR81_RS11290	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
MKR81_RS11305	COG2766	serine protein kinase
MKR81_RS11310	COG2718	Belongs to the UPF0229 family
MKR81_RS11315	COG2719	SpoVR family
MKR81_RS11335	COG1132	(ABC) transporter
MKR81_RS11340	COG0658	competence protein
MKR81_RS11340	COG2333	competence protein COMEC
MKR81_RS11350	COG4591	ABC-type transport system involved in lipoprotein release permease component
MKR81_RS11355	COG1136	(ABC) transporter
MKR81_RS11360	COG4591	ABC-type transport system involved in lipoprotein release permease component
MKR81_RS11370	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MKR81_RS11385	COG1252	NADH dehydrogenase
MKR81_RS11415	COG0537	adenosine 5'-monophosphoramidase activity
MKR81_RS11435	COG2217	Heavy metal translocating P-type atpase
MKR81_RS11445	COG0516	GMP reductase activity
MKR81_RS11445	COG0517	IMP dehydrogenase activity
MKR81_RS11450	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
MKR81_RS11455	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
MKR81_RS11460	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MKR81_RS11470	COG3706	GGDEF domain
MKR81_RS11485	COG3126	Type III secretion system lipoprotein chaperone (YscW)
MKR81_RS11490	COG1946	Acyl-CoA thioesterase
MKR81_RS11495	COG1522	sequence-specific DNA binding
MKR81_RS11520	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MKR81_RS11565	COG2855	membrane
MKR81_RS11575	COG0583	DNA-binding transcription factor activity
MKR81_RS11580	COG2190	(PTS) system
MKR81_RS11580	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MKR81_RS11580	COG1263	PTS System
MKR81_RS11595	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
MKR81_RS11600	COG0596	Alpha beta hydrolase
MKR81_RS11610	COG1169	isochorismate synthase
MKR81_RS11615	COG0436	Aminotransferase
MKR81_RS11620	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
MKR81_RS11640	COG1555	photosystem II stabilization
MKR81_RS11645	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MKR81_RS11650	COG0776	regulation of translation
MKR81_RS11655	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MKR81_RS11690	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
MKR81_RS11695	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
MKR81_RS11700	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MKR81_RS11720	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MKR81_RS11725	COG0569	domain protein
MKR81_RS11730	COG0513	Belongs to the DEAD box helicase family
MKR81_RS11735	COG1253	flavin adenine dinucleotide binding
MKR81_RS11740	COG4771	TonB-dependent receptor
MKR81_RS11745	COG2977	Belongs to the P-Pant transferase superfamily
MKR81_RS11755	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MKR81_RS11755	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MKR81_RS11760	COG1535	isochorismatase
MKR81_RS11760	COG3433	isochorismatase activity
MKR81_RS11765	COG1021	2,3-dihydroxybenzoate-AMP ligase
MKR81_RS11770	COG1169	isochorismate synthase
MKR81_RS11780	COG1028	Short-chain dehydrogenase reductase Sdr
MKR81_RS11890	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MKR81_RS11895	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MKR81_RS11915	COG1216	Glycosyl transferase, family 2
MKR81_RS11920	COG2986	histidine ammonia-lyase
MKR81_RS11955	COG1028	Short-chain dehydrogenase reductase Sdr
MKR81_RS11980	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MKR81_RS11990	COG2951	lytic endotransglycosylase activity
MKR81_RS12005	COG2894	cell division
MKR81_RS12010	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
MKR81_RS12015	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
MKR81_RS12020	COG0318	PFAM AMP-dependent synthetase and ligase
MKR81_RS12025	COG2267	carboxylic ester hydrolase activity
MKR81_RS12030	COG3065	identical protein binding
MKR81_RS12040	COG1214	PFAM Peptidase M22, glycoprotease
MKR81_RS12045	COG1199	ATP-dependent helicase activity
MKR81_RS12055	COG0788	formyltetrahydrofolate deformylase activity
MKR81_RS12070	COG3102	Protein conserved in bacteria
MKR81_RS12100	COG1918	ferrous iron import across plasma membrane
MKR81_RS12105	COG4977	sequence-specific DNA binding
MKR81_RS12110	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
MKR81_RS12115	COG1121	(ABC) transporter
MKR81_RS12120	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MKR81_RS12135	COG0508	dehydrogenase complex catalyzes the overall conversion of
MKR81_RS12140	COG0567	Dehydrogenase, E1 component
MKR81_RS12150	COG1053	succinate dehydrogenase
MKR81_RS12155	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
MKR81_RS12170	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
MKR81_RS12180	COG0033	Phosphoglucomutase
MKR81_RS12185	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
MKR81_RS12190	COG0596	Alpha beta hydrolase
MKR81_RS12210	COG0735	belongs to the Fur family
MKR81_RS12220	COG2190	(PTS) system
MKR81_RS12220	COG1263	PTS System
MKR81_RS12220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MKR81_RS12225	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
MKR81_RS12230	COG1846	Transcriptional regulator
MKR81_RS12230	COG1940	carbohydrate kinase activity
MKR81_RS12235	COG4651	solute:proton antiporter activity
MKR81_RS12235	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MKR81_RS12240	COG0367	asparagine synthase
MKR81_RS12250	COG3104	oligopeptide transport
MKR81_RS12255	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
MKR81_RS12270	COG3710	Transcriptional regulator
MKR81_RS12290	COG0622	Phosphoesterase
MKR81_RS12320	COG1090	epimerase
MKR81_RS12325	COG0300	oxidoreductase activity
MKR81_RS12330	COG3118	belongs to the thioredoxin family
MKR81_RS12335	COG0457	Tetratricopeptide repeat
MKR81_RS12335	COG3118	belongs to the thioredoxin family
MKR81_RS12340	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
MKR81_RS12345	COG1215	transferase activity, transferring glycosyl groups
MKR81_RS12350	COG1215	transferase activity, transferring glycosyl groups
MKR81_RS12355	COG1192	Involved in chromosome partitioning
MKR81_RS12375	COG2194	sulfuric ester hydrolase activity
MKR81_RS12380	COG0330	HflC and HflK could
MKR81_RS12415	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
MKR81_RS12420	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MKR81_RS12425	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
MKR81_RS12430	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MKR81_RS12435	COG2190	(PTS) system
MKR81_RS12440	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MKR81_RS12445	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MKR81_RS12450	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MKR81_RS12470	COG1705	Flagellar rod assembly protein muramidase FlgJ
MKR81_RS12470	COG3951	Flagellar rod assembly protein muramidase FlgJ
MKR81_RS12475	COG1706	bacterial-type flagellum-dependent cell motility
MKR81_RS12480	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
MKR81_RS12490	COG4787	bacterial-type flagellum-dependent cell motility
MKR81_RS12495	COG1749	Flagellar hook protein flgE
MKR81_RS12505	COG1558	bacterial-type flagellum-dependent cell motility
MKR81_RS12510	COG1815	bacterial-type flagellum-dependent cell motility
MKR81_RS12515	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
MKR81_RS12520	COG0784	Response regulator, receiver
MKR81_RS12520	COG0835	chemotaxis
MKR81_RS12575	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
MKR81_RS12585	COG2217	Heavy metal translocating P-type atpase
MKR81_RS12585	COG2608	mercury ion transmembrane transporter activity
MKR81_RS12625	COG2840	Smr protein MutS2
MKR81_RS12630	COG1187	pseudouridine synthase activity
MKR81_RS12635	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
MKR81_RS12640	COG0737	Belongs to the 5'-nucleotidase family
MKR81_RS12650	COG2912	Transglutaminase-like superfamily
MKR81_RS12655	COG3094	Invasion gene expression up-regulator, SirB
MKR81_RS12660	COG2890	protein-(glutamine-N5) methyltransferase activity
MKR81_RS12685	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MKR81_RS12795	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MKR81_RS12805	COG1702	phosphate starvation-inducible protein PhoH
MKR81_RS12815	COG4535	Mg2 and Co2 transporter CorC
MKR81_RS12820	COG0815	Transfers the fatty acyl group on membrane lipoproteins
MKR81_RS12825	COG2888	peptidyl-tyrosine sulfation
MKR81_RS12835	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
MKR81_RS12840	COG1466	dna polymerase III delta subunit
MKR81_RS12845	COG0799	negative regulation of ribosome biogenesis
MKR81_RS12855	COG0768	penicillin binding
MKR81_RS12860	COG0772	Belongs to the SEDS family
MKR81_RS12865	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
MKR81_RS12870	COG1686	Belongs to the peptidase S11 family
MKR81_RS12890	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MKR81_RS12895	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MKR81_RS12900	COG0366	Alpha amylase catalytic
MKR81_RS12905	COG1263	PTS System
MKR81_RS12905	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MKR81_RS12915	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
MKR81_RS12920	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MKR81_RS12925	COG2011	ABC-type metal ion transport system permease component
MKR81_RS12930	COG1464	Belongs to the NlpA lipoprotein family
MKR81_RS12940	COG0737	Belongs to the 5'-nucleotidase family
MKR81_RS12945	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
MKR81_RS12970	COG1611	Belongs to the LOG family
MKR81_RS12990	COG2363	Small membrane protein
MKR81_RS13000	COG0583	DNA-binding transcription factor activity
MKR81_RS13015	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
MKR81_RS13025	COG0142	geranyltranstransferase activity
MKR81_RS13035	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
MKR81_RS13040	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
MKR81_RS13065	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MKR81_RS13065	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MKR81_RS13070	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MKR81_RS13075	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MKR81_RS13090	COG1073	alpha beta
MKR81_RS13100	COG2252	PERMEase
MKR81_RS13105	COG2195	Cleaves the N-terminal amino acid of tripeptides
MKR81_RS13130	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MKR81_RS13130	COG0047	phosphoribosylformylglycinamidine synthase activity
MKR81_RS13140	COG0590	tRNA wobble adenosine to inosine editing
MKR81_RS13145	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
MKR81_RS13165	COG4969	Belongs to the N-Me-Phe pilin family
MKR81_RS13185	COG1301	dicarboxylic acid transport
MKR81_RS13200	COG0497	DNA recombination
MKR81_RS13205	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MKR81_RS13210	COG2914	Belongs to the UPF0125 (RnfH) family
MKR81_RS13215	COG2867	negative regulation of translational initiation
MKR81_RS13230	COG0583	DNA-binding transcription factor activity
MKR81_RS13235	COG1289	transmembrane transporter activity
MKR81_RS13255	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MKR81_RS13265	COG0668	transmembrane transport
MKR81_RS13285	COG0583	DNA-binding transcription factor activity
MKR81_RS13295	COG1115	amino acid carrier protein
MKR81_RS13300	COG1584	GPR1 FUN34 yaaH family protein
MKR81_RS13310	COG1757	Na H antiporter
MKR81_RS13320	COG0517	IMP dehydrogenase activity
MKR81_RS13320	COG0516	GMP reductase activity
MKR81_RS13335	COG2203	Gaf domain
MKR81_RS13335	COG2199	diguanylate cyclase activity
MKR81_RS13350	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MKR81_RS13355	COG2976	Protein conserved in bacteria
MKR81_RS13390	COG2975	iron-sulfur cluster assembly
MKR81_RS13395	COG0633	Ferredoxin
MKR81_RS13410	COG0316	Belongs to the HesB IscA family
MKR81_RS13415	COG0822	iron-sulfur transferase activity
MKR81_RS13430	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
MKR81_RS13435	COG0483	inositol monophosphate 1-phosphatase activity
MKR81_RS13445	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MKR81_RS13450	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MKR81_RS13455	COG1862	Preprotein translocase
MKR81_RS13480	COG0517	IMP dehydrogenase activity
MKR81_RS13490	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
MKR81_RS13495	COG0583	DNA-binding transcription factor activity
MKR81_RS13500	COG0450	alkyl hydroperoxide reductase
MKR81_RS13530	COG0704	Plays a role in the regulation of phosphate uptake
MKR81_RS13535	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MKR81_RS13540	COG0581	inorganic phosphate transmembrane transporter activity
MKR81_RS13545	COG0573	inorganic phosphate transmembrane transporter activity
MKR81_RS13550	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
MKR81_RS13555	COG0248	Ppx GppA phosphatase
MKR81_RS13565	COG5002	protein histidine kinase activity
MKR81_RS13570	COG0745	RESPONSE REGULATOR receiver
MKR81_RS13580	COG0826	peptidase U32
MKR81_RS13585	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
MKR81_RS13640	COG0542	response to heat
MKR81_RS13650	COG0564	pseudouridine synthase activity
MKR81_RS13655	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MKR81_RS13660	COG0741	lytic transglycosylase activity
MKR81_RS13665	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
MKR81_RS13670	COG0077	Prephenate dehydratase
MKR81_RS13670	COG1605	Chorismate mutase
MKR81_RS13675	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
MKR81_RS13690	COG0488	(ABC) transporter
MKR81_RS13700	COG0739	heme binding
MKR81_RS13705	COG0287	Prephenate dehydrogenase
MKR81_RS13705	COG1605	Chorismate mutase
MKR81_RS13710	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
MKR81_RS13720	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
MKR81_RS13740	COG1966	Carbon starvation protein
MKR81_RS13745	COG3275	phosphorelay sensor kinase activity
MKR81_RS13750	COG3279	Response regulator of the LytR AlgR family
MKR81_RS13755	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
MKR81_RS13760	COG1047	Peptidyl-prolyl cis-trans
MKR81_RS13775	COG0196	riboflavin kinase activity
MKR81_RS13780	COG0728	peptidoglycan biosynthetic process
MKR81_RS13785	COG0268	Binds directly to 16S ribosomal RNA
MKR81_RS13790	COG0640	Transcriptional regulator
MKR81_RS13795	COG0583	DNA-binding transcription factor activity
MKR81_RS13800	COG1283	sodium-dependent phosphate transmembrane transporter activity
MKR81_RS13815	COG0730	response to heat
MKR81_RS13840	COG0667	Aldo Keto reductase
MKR81_RS13865	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
MKR81_RS13870	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MKR81_RS13875	COG4974	Belongs to the 'phage' integrase family
MKR81_RS13880	COG0716	FMN binding
MKR81_RS13895	COG0513	Belongs to the DEAD box helicase family
MKR81_RS13905	COG3022	response to hydroperoxide
MKR81_RS13945	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MKR81_RS13950	COG0083	homoserine kinase activity
MKR81_RS13965	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
MKR81_RS13975	COG0745	RESPONSE REGULATOR receiver
MKR81_RS13985	COG0784	Response regulator, receiver
MKR81_RS13985	COG2198	Histidine kinase
MKR81_RS13985	COG5002	protein histidine kinase activity
MKR81_RS13990	COG3706	GGDEF domain
MKR81_RS13990	COG2203	Gaf domain
MKR81_RS13990	COG4251	negative regulation of phosphorylation
MKR81_RS13990	COG5001	Diguanylate cyclase
MKR81_RS13995	COG1242	4 iron, 4 sulfur cluster binding
MKR81_RS14000	COG0067	glutamate synthase
MKR81_RS14000	COG0070	glutamate synthase
MKR81_RS14000	COG0069	glutamate synthase activity
MKR81_RS14010	COG0067	glutamate synthase
MKR81_RS14010	COG0069	glutamate synthase activity
MKR81_RS14010	COG0070	glutamate synthase
MKR81_RS14015	COG0493	'glutamate synthase
MKR81_RS14040	COG2860	membrane
MKR81_RS14045	COG0583	DNA-binding transcription factor activity
MKR81_RS14050	COG0730	response to heat
MKR81_RS14065	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MKR81_RS14070	COG0505	Belongs to the CarA family
MKR81_RS14080	COG0494	nUDIX hydrolase
MKR81_RS14100	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MKR81_RS14105	COG0849	cell division
MKR81_RS14110	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
MKR81_RS14125	COG0772	Belongs to the SEDS family
MKR81_RS14140	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MKR81_RS14145	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MKR81_RS14150	COG0768	penicillin binding
MKR81_RS14155	COG3116	cell division
MKR81_RS14170	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
MKR81_RS14185	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
MKR81_RS14190	COG2823	Periplasmic or secreted lipoprotein
MKR81_RS14195	COG2969	positive regulation of protein catabolic process
MKR81_RS14200	COG0625	glutathione transferase activity
MKR81_RS14205	COG2857	Cytochrome c1
MKR81_RS14210	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
MKR81_RS14215	COG0723	plastoquinol--plastocyanin reductase activity
MKR81_RS14230	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
MKR81_RS14235	COG3105	Protein conserved in bacteria
MKR81_RS14240	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MKR81_RS14245	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MKR81_RS14250	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MKR81_RS14260	COG3150	esterase
MKR81_RS14270	COG3151	Protein conserved in bacteria
MKR81_RS14275	COG0494	nUDIX hydrolase
MKR81_RS14280	COG1538	Outer membrane efflux protein
MKR81_RS14290	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
MKR81_RS14300	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MKR81_RS14305	COG3025	triphosphatase activity
MKR81_RS14310	COG1392	Phosphate transport regulator
MKR81_RS14315	COG0306	phosphate transporter
MKR81_RS14320	COG4991	sh3 domain protein
MKR81_RS14325	COG0405	Gamma-glutamyltransferase
MKR81_RS14335	COG3409	Peptidoglycan-binding domain 1 protein
MKR81_RS14335	COG3267	Type II secretory pathway component ExeA
MKR81_RS14350	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MKR81_RS14355	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
MKR81_RS14365	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MKR81_RS14370	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MKR81_RS14375	COG0828	Belongs to the bacterial ribosomal protein bS21 family
MKR81_RS14380	COG1610	YqeY-like protein
MKR81_RS14385	COG0358	DNA primase activity
MKR81_RS14425	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
MKR81_RS14425	COG2213	PTS system mannitol-specific
MKR81_RS14435	COG3722	fumarate hydratase activity
MKR81_RS14440	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MKR81_RS14450	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MKR81_RS14455	COG1349	DNA-binding transcription factor activity
MKR81_RS14460	COG0469	pyruvate kinase activity
MKR81_RS14470	COG3706	GGDEF domain
MKR81_RS14475	COG0440	acetolactate synthase activity
MKR81_RS14480	COG0028	Belongs to the TPP enzyme family
MKR81_RS14485	COG1022	Amp-dependent synthetase and ligase
MKR81_RS14490	COG0583	DNA-binding transcription factor activity
MKR81_RS14515	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MKR81_RS14520	COG0473	3-isopropylmalate dehydrogenase activity
MKR81_RS14540	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
MKR81_RS14545	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
MKR81_RS14550	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MKR81_RS14555	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
MKR81_RS14580	COG3610	response to peptide
MKR81_RS14585	COG2966	Psort location CytoplasmicMembrane, score
MKR81_RS14600	COG0261	This protein binds to 23S rRNA in the presence of protein L20
MKR81_RS14605	COG0142	geranyltranstransferase activity
MKR81_RS14625	COG2358	TRAP transporter, solute receptor (TAXI family
MKR81_RS14640	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
MKR81_RS14645	COG1178	ABC-type Fe3 transport system permease component
MKR81_RS14650	COG4143	(ABC) transporter
MKR81_RS14655	COG0163	prenyltransferase activity
MKR81_RS14660	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MKR81_RS14670	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
MKR81_RS14685	COG2105	PFAM AIG2 family protein
MKR81_RS14695	COG0729	surface antigen
MKR81_RS14700	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MKR81_RS14710	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
MKR81_RS14725	COG1136	(ABC) transporter
MKR81_RS14745	COG0529	Catalyzes the synthesis of activated sulfate
MKR81_RS14750	COG0471	metal ion transport
MKR81_RS14750	COG3273	potassium ion transport
MKR81_RS14765	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MKR81_RS14765	COG1648	precorrin-2 dehydrogenase activity
MKR81_RS14770	COG0737	Belongs to the 5'-nucleotidase family
MKR81_RS14780	COG0513	Belongs to the DEAD box helicase family
MKR81_RS14785	COG2153	protein acetylation
MKR81_RS14800	COG0545	Peptidyl-prolyl cis-trans isomerase
MKR81_RS14810	COG0203	ribosomal protein L17
MKR81_RS14815	COG0202	RNA polymerase activity
MKR81_RS14825	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MKR81_RS14830	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MKR81_RS14835	COG0257	Belongs to the bacterial ribosomal protein bL36 family
MKR81_RS14840	COG0201	protein transport
MKR81_RS14850	COG1841	ribosomal large subunit assembly
MKR81_RS14935	COG0088	Forms part of the polypeptide exit tunnel
MKR81_RS14955	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MKR81_RS14960	COG1609	Transcriptional regulator
MKR81_RS14980	COG1575	Belongs to the MenA family. Type 1 subfamily
MKR81_RS14985	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
MKR81_RS14995	COG1494	fructose-1,6-bisphosphatase
MKR81_RS15025	COG0149	triose-phosphate isomerase activity
MKR81_RS15045	COG1215	transferase activity, transferring glycosyl groups
MKR81_RS15110	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MKR81_RS15115	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
MKR81_RS15120	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MKR81_RS15165	COG1086	Polysaccharide biosynthesis protein
MKR81_RS15200	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MKR81_RS15205	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MKR81_RS15210	COG1560	Kdo2-lipid A biosynthetic process
MKR81_RS15220	COG1519	Transferase
MKR81_RS15230	COG2089	acid synthase
MKR81_RS15240	COG1083	cytidylyl-transferase
MKR81_RS15245	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MKR81_RS15250	COG1086	Polysaccharide biosynthesis protein
MKR81_RS15255	COG3642	lipopolysaccharide core region biosynthetic process
MKR81_RS15260	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
MKR81_RS15265	COG0859	PFAM glycosyl transferase family 9
MKR81_RS15270	COG0463	Glycosyl transferase, family 2
MKR81_RS15325	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MKR81_RS15335	COG1560	Kdo2-lipid A biosynthetic process
MKR81_RS15340	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MKR81_RS15345	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
MKR81_RS15350	COG1561	YicC-like family, N-terminal region
MKR81_RS15370	COG4608	Belongs to the ABC transporter superfamily
MKR81_RS15375	COG0444	Belongs to the ABC transporter superfamily
MKR81_RS15380	COG0747	negative chemotaxis
MKR81_RS15385	COG4239	(ABC) transporter, permease
MKR81_RS15390	COG4174	ABC transporter (Permease)
MKR81_RS15410	COG0811	peptide transport
MKR81_RS15415	COG0848	biopolymer transport protein
MKR81_RS15430	COG0194	GDP metabolic process
MKR81_RS15435	COG1758	RNA polymerase activity
MKR81_RS15440	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MKR81_RS15445	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MKR81_RS15450	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MKR81_RS15460	COG2233	PERMEase
MKR81_RS15475	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MKR81_RS15485	COG2183	response to ionizing radiation
MKR81_RS15500	COG1040	competence protein
MKR81_RS15510	COG0494	nUDIX hydrolase
MKR81_RS15515	COG1218	3'(2'),5'-bisphosphate nucleotidase
MKR81_RS15525	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
MKR81_RS15530	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
MKR81_RS15535	COG3156	type II secretion system protein K
MKR81_RS15540	COG4795	General secretion pathway protein
MKR81_RS15545	COG2165	general secretion pathway protein
MKR81_RS15550	COG2165	general secretion pathway protein
MKR81_RS15555	COG2165	general secretion pathway protein
MKR81_RS15560	COG1459	type II secretion system
MKR81_RS15565	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MKR81_RS15575	COG3031	protein transport across the cell outer membrane
MKR81_RS15580	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
MKR81_RS15600	COG0456	acetyltransferase
MKR81_RS15605	COG1490	D-aminoacyl-tRNA deacylase activity
MKR81_RS15625	COG1217	gtp-binding protein TYPA
MKR81_RS15630	COG0174	glutamine synthetase
MKR81_RS15640	COG3852	Histidine kinase
MKR81_RS15645	COG2204	response regulator
MKR81_RS15655	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
MKR81_RS15685	COG0218	Necessary for normal cell division and for the maintenance of normal septation
MKR81_RS15690	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MKR81_RS15690	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MKR81_RS15705	COG0084	hydrolase, TatD family'
MKR81_RS15710	COG0805	protein transport
MKR81_RS15715	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MKR81_RS15730	COG3165	ubiquinone biosynthetic process from chorismate
MKR81_RS15740	COG1322	Protein conserved in bacteria
MKR81_RS15755	COG1910	domain protein
MKR81_RS15780	COG2081	HI0933 family
MKR81_RS15790	COG1528	Iron-storage protein
MKR81_RS15795	COG0589	response to stress
MKR81_RS15815	COG5001	Diguanylate cyclase
MKR81_RS15815	COG5002	protein histidine kinase activity
MKR81_RS15820	COG1522	sequence-specific DNA binding
MKR81_RS15830	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
MKR81_RS15840	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MKR81_RS15885	COG3501	Rhs element vgr protein
MKR81_RS15920	COG0800	Aldolase
MKR81_RS15925	COG2610	gluconate transmembrane transporter activity
MKR81_RS15930	COG3265	gluconokinase activity
MKR81_RS15935	COG0129	dihydroxy-acid dehydratase activity
MKR81_RS15945	COG2076	Multidrug Resistance protein
MKR81_RS15950	COG0583	DNA-binding transcription factor activity
MKR81_RS15955	COG1609	Transcriptional regulator
MKR81_RS15960	COG0515	serine threonine protein kinase
MKR81_RS15990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MKR81_RS15995	COG0601	transmembrane transport
MKR81_RS16005	COG4172	Belongs to the ABC transporter superfamily
MKR81_RS16050	COG1309	transcriptional regulator
MKR81_RS16055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MKR81_RS16060	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MKR81_RS16065	COG2960	long-chain fatty acid transporting porin activity
MKR81_RS16070	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MKR81_RS16075	COG0583	DNA-binding transcription factor activity
MKR81_RS16115	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
MKR81_RS16140	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MKR81_RS16145	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
MKR81_RS16150	COG0551	DNA topoisomerase type I activity
MKR81_RS16160	COG0758	DNA mediated transformation
MKR81_RS16180	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MKR81_RS16180	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MKR81_RS16185	COG0569	domain protein
MKR81_RS16190	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MKR81_RS16200	COG1272	protein, Hemolysin III
MKR81_RS16205	COG4326	sporulation control protein
MKR81_RS16215	COG3084	Protein conserved in bacteria
MKR81_RS16225	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
MKR81_RS16230	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MKR81_RS16235	COG0204	Acyl-transferase
MKR81_RS16245	COG2199	diguanylate cyclase activity
MKR81_RS16250	COG0606	chelatase, subunit chli
MKR81_RS16260	COG3978	acetolactate synthase activity
MKR81_RS16265	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MKR81_RS16270	COG0129	dihydroxy-acid dehydratase activity
MKR81_RS16280	COG0583	DNA-binding transcription factor activity
MKR81_RS16285	COG2814	Major facilitator Superfamily
MKR81_RS16290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MKR81_RS16295	COG0765	amino acid transport
MKR81_RS16305	COG0355	proton-transporting ATP synthase activity, rotational mechanism
MKR81_RS16315	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MKR81_RS16345	COG3312	ion transport
MKR81_RS16350	COG1475	DNA binding
MKR81_RS16355	COG1192	Involved in chromosome partitioning
MKR81_RS16370	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
MKR81_RS16400	COG1126	abc transporter atp-binding protein
MKR81_RS16415	COG0581	inorganic phosphate transmembrane transporter activity
MKR81_RS16420	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MKR81_RS16435	COG2304	oxidoreductase activity
MKR81_RS16455	COG0714	Associated with various cellular activities
MKR81_RS16475	COG0840	transmembrane signaling receptor activity
MKR81_RS16485	COG2197	response regulator
MKR81_RS16510	COG0110	maltose O-acetyltransferase activity
MKR81_RS16515	COG2204	response regulator
MKR81_RS16520	COG4191	Histidine kinase
MKR81_RS16525	COG1028	Short-chain dehydrogenase reductase Sdr
MKR81_RS16575	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MKR81_RS16580	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
MKR81_RS16590	COG1252	NADH dehydrogenase
MKR81_RS16595	COG1301	dicarboxylic acid transport
MKR81_RS16600	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MKR81_RS16610	COG1566	PFAM secretion protein HlyD family protein
MKR81_RS16640	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MKR81_RS16640	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MKR81_RS16640	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MKR81_RS16645	COG2207	Transcriptional regulator
MKR81_RS16655	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MKR81_RS16660	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MKR81_RS16670	COG2084	Dehydrogenase
MKR81_RS16675	COG0753	catalase activity
MKR81_RS16685	COG2130	NADP-dependent
MKR81_RS16690	COG1309	transcriptional regulator
MKR81_RS16735	COG0489	protein tyrosine kinase activity
MKR81_RS16735	COG3206	protein involved in exopolysaccharide biosynthesis
MKR81_RS16750	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MKR81_RS16755	COG2200	EAL domain
MKR81_RS16760	COG3842	ATPase activity
MKR81_RS16770	COG1175	transmembrane transport
MKR81_RS16775	COG3833	ABC-type maltose transport systems, permease component
MKR81_RS16805	COG2354	Protein conserved in bacteria
MKR81_RS16815	COG0401	homolog of Blt101
MKR81_RS16820	COG0633	Ferredoxin
MKR81_RS16820	COG3217	Mosc domain protein beta barrel domain protein
MKR81_RS16820	COG0633	Ferredoxin
MKR81_RS16820	COG3217	Mosc domain protein beta barrel domain protein
MKR81_RS16830	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MKR81_RS16870	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
MKR81_RS16875	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MKR81_RS16885	COG0848	biopolymer transport protein
MKR81_RS16890	COG0811	peptide transport
MKR81_RS16895	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
MKR81_RS16905	COG3721	Heme iron utilization protein
MKR81_RS16910	COG0748	coenzyme F420 binding
MKR81_RS16925	COG0835	chemotaxis
MKR81_RS16925	COG0784	Response regulator, receiver
MKR81_RS16930	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MKR81_RS16935	COG0366	Alpha amylase catalytic
MKR81_RS16975	COG0583	DNA-binding transcription factor activity
MKR81_RS16995	COG0583	DNA-binding transcription factor activity
MKR81_RS17015	COG2814	Major facilitator Superfamily
MKR81_RS17025	COG4977	sequence-specific DNA binding
MKR81_RS17030	COG0673	inositol 2-dehydrogenase activity
MKR81_RS17035	COG2194	sulfuric ester hydrolase activity
MKR81_RS17040	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
MKR81_RS17050	COG2205	protein histidine kinase activity
MKR81_RS17055	COG0745	RESPONSE REGULATOR receiver
MKR81_RS17065	COG4221	oxidoreductase activity
MKR81_RS17080	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MKR81_RS17100	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MKR81_RS17125	COG1418	mRNA catabolic process
MKR81_RS17140	COG0402	S-adenosylhomocysteine deaminase activity
MKR81_RS17145	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
MKR81_RS17150	COG2239	Acts as a magnesium transporter
MKR81_RS17155	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
MKR81_RS17160	COG1566	PFAM secretion protein HlyD family protein
MKR81_RS17185	COG0745	RESPONSE REGULATOR receiver
MKR81_RS17190	COG2205	protein histidine kinase activity
MKR81_RS17200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MKR81_RS17205	COG0531	amino acid
MKR81_RS17220	COG0583	DNA-binding transcription factor activity
MKR81_RS17245	COG0784	Response regulator, receiver
MKR81_RS17245	COG2205	protein histidine kinase activity
MKR81_RS17245	COG5002	protein histidine kinase activity
MKR81_RS17250	COG0673	inositol 2-dehydrogenase activity
MKR81_RS17325	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MKR81_RS17330	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MKR81_RS17340	COG1280	lysine exporter protein (LysE YggA)
MKR81_RS17350	COG0183	Belongs to the thiolase family
MKR81_RS17370	COG3005	denitrification pathway
MKR81_RS17390	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
MKR81_RS17395	COG3850	Histidine kinase
MKR81_RS17400	COG2197	response regulator
MKR81_RS17415	COG2195	Cleaves the N-terminal amino acid of tripeptides
MKR81_RS17435	COG0840	transmembrane signaling receptor activity
MKR81_RS17445	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MKR81_RS17450	COG0545	Peptidyl-prolyl cis-trans isomerase
MKR81_RS17480	COG1278	Cold shock
MKR81_RS17485	COG3036	rescue of stalled ribosome
MKR81_RS17515	COG0577	efflux transmembrane transporter activity
MKR81_RS17515	COG1136	(ABC) transporter
MKR81_RS17525	COG0840	transmembrane signaling receptor activity
MKR81_RS17530	COG0783	Belongs to the Dps family
MKR81_RS17540	COG1619	proteins homologs of microcin C7 resistance protein MccF
MKR81_RS17545	COG2133	pyrroloquinoline quinone binding
MKR81_RS17550	COG1454	alcohol dehydrogenase
MKR81_RS17555	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
MKR81_RS17580	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MKR81_RS17590	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MKR81_RS17595	COG3186	Phenylalanine-4-hydroxylase
MKR81_RS17625	COG3530	Putative quorum-sensing-regulated virulence factor
MKR81_RS17655	COG0523	cobalamin synthesis protein
MKR81_RS17660	COG3447	MASE1 domain protein
MKR81_RS17660	COG5001	Diguanylate cyclase
MKR81_RS17660	COG5002	protein histidine kinase activity
MKR81_RS17665	COG0513	Belongs to the DEAD box helicase family
MKR81_RS17685	COG2200	EAL domain
MKR81_RS17690	COG1119	ATPase activity
MKR81_RS17745	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
MKR81_RS17760	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
MKR81_RS17765	COG0513	Belongs to the DEAD box helicase family
MKR81_RS17855	COG1609	Transcriptional regulator
MKR81_RS17865	COG2182	Extracellular solute-binding protein
MKR81_RS17875	COG3833	ABC-type maltose transport systems, permease component
MKR81_RS17885	COG1874	Beta-galactosidase
MKR81_RS17890	COG4580	involved in the transport of maltose and maltodextrins
MKR81_RS17895	COG0840	transmembrane signaling receptor activity
MKR81_RS17900	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MKR81_RS17955	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MKR81_RS17960	COG3550	peptidyl-serine autophosphorylation
MKR81_RS17970	COG2814	Major facilitator Superfamily
MKR81_RS17975	COG0583	DNA-binding transcription factor activity
MKR81_RS17995	COG1902	pentaerythritol trinitrate reductase activity
MKR81_RS18000	COG1902	pentaerythritol trinitrate reductase activity
MKR81_RS18010	COG1733	regulation of RNA biosynthetic process
MKR81_RS18055	COG3278	Belongs to the heme-copper respiratory oxidase family
MKR81_RS18100	COG1024	Enoyl-CoA hydratase
MKR81_RS18105	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MKR81_RS18110	COG1960	acyl-CoA dehydrogenase activity
MKR81_RS18120	COG0183	Belongs to the thiolase family
MKR81_RS18135	COG1024	Enoyl-CoA hydratase
MKR81_RS18140	COG1024	Enoyl-CoA hydratase
MKR81_RS18150	COG1028	Short-chain dehydrogenase reductase Sdr
MKR81_RS18155	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MKR81_RS18160	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MKR81_RS18165	COG1845	cytochrome c oxidase, subunit III
MKR81_RS18170	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
MKR81_RS18185	COG1902	pentaerythritol trinitrate reductase activity
MKR81_RS18185	COG0446	pyridine nucleotide-disulphide oxidoreductase
MKR81_RS18200	COG1012	belongs to the aldehyde dehydrogenase family
MKR81_RS18210	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MKR81_RS18265	COG1126	abc transporter atp-binding protein
MKR81_RS18270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MKR81_RS18275	COG4215	(ABC) transporter
MKR81_RS18280	COG4160	amino acid transport
MKR81_RS18290	COG0583	DNA-binding transcription factor activity
MKR81_RS18305	COG2200	EAL domain
MKR81_RS18350	COG0443	Heat shock 70 kDa protein
MKR81_RS18390	COG0745	RESPONSE REGULATOR receiver
MKR81_RS18405	COG1785	Belongs to the alkaline phosphatase family
MKR81_RS18430	COG0814	amino acid
MKR81_RS18435	COG5002	protein histidine kinase activity
MKR81_RS18435	COG5001	Diguanylate cyclase
MKR81_RS18445	COG0243	molybdopterin cofactor binding
MKR81_RS18465	COG3707	response regulator
MKR81_RS18470	COG1116	anion transmembrane transporter activity
MKR81_RS18470	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MKR81_RS18475	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MKR81_RS18480	COG1116	anion transmembrane transporter activity
MKR81_RS18485	COG2146	nitrite reductase [NAD(P)H] activity
MKR81_RS18485	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MKR81_RS18520	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MKR81_RS18540	COG0739	heme binding
MKR81_RS18550	COG3038	cytochrome b561
MKR81_RS18660	COG2814	Major facilitator Superfamily
MKR81_RS18680	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MKR81_RS18685	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MKR81_RS18695	COG1132	(ABC) transporter
MKR81_RS18705	COG5640	endopeptidase activity
MKR81_RS18725	COG0583	DNA-binding transcription factor activity
MKR81_RS18760	COG1120	ATPase activity
MKR81_RS18765	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MKR81_RS18770	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MKR81_RS18775	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
MKR81_RS18800	COG4977	sequence-specific DNA binding
MKR81_RS18815	COG3547	Transposase (IS116 IS110 IS902 family)
MKR81_RS18890	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MKR81_RS18900	COG0404	The glycine cleavage system catalyzes the degradation of glycine
MKR81_RS18910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MKR81_RS18915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MKR81_RS18930	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MKR81_RS18930	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MKR81_RS18930	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
MKR81_RS18935	COG1105	Belongs to the carbohydrate kinase PfkB family
MKR81_RS18940	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
MKR81_RS18940	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
MKR81_RS18945	COG1609	Transcriptional regulator
MKR81_RS18960	COG2199	diguanylate cyclase activity
MKR81_RS18960	COG2200	EAL domain
MKR81_RS18960	COG2203	Gaf domain
MKR81_RS18965	COG0765	amino acid transport
MKR81_RS18970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MKR81_RS18975	COG0765	amino acid transport
MKR81_RS18980	COG1126	abc transporter atp-binding protein
MKR81_RS18990	COG1979	alcohol dehydrogenase
MKR81_RS18995	COG2207	Transcriptional regulator
MKR81_RS19005	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MKR81_RS19015	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MKR81_RS19030	COG3437	response regulator, receiver
MKR81_RS19030	COG0784	Response regulator, receiver
MKR81_RS19035	COG0546	phosphoglycolate phosphatase activity
MKR81_RS19040	COG0840	transmembrane signaling receptor activity
MKR81_RS19045	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
MKR81_RS19050	COG0513	Belongs to the DEAD box helicase family
MKR81_RS19055	COG4943	cyclic-guanylate-specific phosphodiesterase activity
MKR81_RS19070	COG3038	cytochrome b561
MKR81_RS19080	COG2116	formate transmembrane transporter activity
MKR81_RS19085	COG0583	DNA-binding transcription factor activity
MKR81_RS19095	COG3593	DNA synthesis involved in DNA repair
MKR81_RS19100	COG0737	Belongs to the 5'-nucleotidase family
MKR81_RS19115	COG0646	methionine synthase
MKR81_RS19115	COG1410	methionine synthase
MKR81_RS19130	COG2267	carboxylic ester hydrolase activity
MKR81_RS19135	COG2067	long-chain fatty acid transport protein
MKR81_RS19145	COG0501	Belongs to the peptidase M48B family
MKR81_RS19150	COG2050	protein possibly involved in aromatic compounds catabolism
MKR81_RS19195	COG3300	MHYT domain
MKR81_RS19195	COG5001	Diguanylate cyclase
MKR81_RS19200	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
MKR81_RS19210	COG4181	ATPase activity
MKR81_RS19215	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
MKR81_RS19225	COG1984	allophanate hydrolase subunit 2
MKR81_RS19230	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
MKR81_RS19240	COG5002	protein histidine kinase activity
MKR81_RS19240	COG3447	MASE1 domain protein
MKR81_RS19240	COG5001	Diguanylate cyclase
MKR81_RS19245	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MKR81_RS19255	COG0583	DNA-binding transcription factor activity
MKR81_RS19260	COG0045	succinate-CoA ligase (ADP-forming) activity
MKR81_RS19260	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MKR81_RS19260	COG1042	CoA-binding domain protein
MKR81_RS19280	COG0023	Translation Initiation Factor
MKR81_RS19295	COG3140	Belongs to the UPF0181 family
MKR81_RS19320	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
MKR81_RS19325	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
MKR81_RS19345	COG5001	Diguanylate cyclase
MKR81_RS19345	COG3706	GGDEF domain
MKR81_RS19345	COG4251	negative regulation of phosphorylation
MKR81_RS19345	COG2203	Gaf domain
MKR81_RS19355	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
MKR81_RS19360	COG4149	molybdate abc transporter
MKR81_RS19365	COG0725	ABC transporter, periplasmic molybdate-binding protein
MKR81_RS19375	COG3111	PFAM Bacterial OB fold (BOF) protein
MKR81_RS19400	COG0534	Mate efflux family protein
MKR81_RS19405	COG0602	queuosine metabolic process
MKR81_RS19410	COG1328	CTP reductase activity
MKR81_RS19470	COG2197	response regulator
MKR81_RS19475	COG3851	Histidine kinase
MKR81_RS19480	COG2271	Major facilitator Superfamily
MKR81_RS19485	COG1482	cell wall glycoprotein biosynthetic process
MKR81_RS19495	COG0628	permease
MKR81_RS19505	COG1566	PFAM secretion protein HlyD family protein
MKR81_RS19530	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MKR81_RS19535	COG3118	belongs to the thioredoxin family
MKR81_RS19565	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
MKR81_RS19585	COG2116	formate transmembrane transporter activity
MKR81_RS19595	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MKR81_RS19605	COG2199	diguanylate cyclase activity
MKR81_RS19690	COG0277	FAD linked oxidase domain protein
MKR81_RS19695	COG0583	DNA-binding transcription factor activity
MKR81_RS19710	COG2425	protein containing a von Willebrand factor type A (vWA) domain
MKR81_RS19725	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
MKR81_RS19735	COG1288	antiporter activity
MKR81_RS19745	COG2814	Major facilitator Superfamily
MKR81_RS19755	COG3040	lipid binding
MKR81_RS19785	COG3469	chitinase activity
MKR81_RS19795	COG0419	ATPase involved in DNA repair
MKR81_RS19800	COG0420	3'-5' exonuclease activity
MKR81_RS19810	COG3209	COG3209 Rhs family protein
MKR81_RS19880	COG0631	protein serine/threonine phosphatase activity
MKR81_RS19915	COG2815	serine threonine protein kinase
MKR81_RS19915	COG0515	serine threonine protein kinase
MKR81_RS19945	COG0346	lactoylglutathione lyase activity
MKR81_RS19950	COG1902	pentaerythritol trinitrate reductase activity
MKR81_RS19960	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
MKR81_RS19960	COG2755	lipolytic protein G-D-S-L family
MKR81_RS19970	COG5642	Protein of unknown function (DUF2384)
MKR81_RS19985	COG1234	tRNA 3'-trailer cleavage
MKR81_RS19990	COG2067	long-chain fatty acid transport protein
MKR81_RS20040	COG0671	phosphoesterase, PA-phosphatase related
MKR81_RS20055	COG2962	Rard protein
MKR81_RS20065	COG2165	general secretion pathway protein
MKR81_RS20070	COG0784	Response regulator, receiver
MKR81_RS20070	COG0835	chemotaxis
MKR81_RS20075	COG0778	Nitroreductase
MKR81_RS20080	COG2197	response regulator
MKR81_RS20090	COG3706	GGDEF domain
MKR81_RS20095	COG2197	response regulator
MKR81_RS20100	COG5001	Diguanylate cyclase
MKR81_RS20100	COG3300	MHYT domain
MKR81_RS20105	COG0784	Response regulator, receiver
MKR81_RS20105	COG2205	protein histidine kinase activity
MKR81_RS20120	COG4771	TonB-dependent receptor
MKR81_RS20235	COG1522	sequence-specific DNA binding
MKR81_RS20270	COG0515	serine threonine protein kinase
MKR81_RS20295	COG3501	Rhs element vgr protein
MKR81_RS20310	COG2204	response regulator
MKR81_RS20340	COG0739	heme binding
MKR81_RS20345	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
MKR81_RS20375	COG3069	C4-dicarboxylate transmembrane transporter activity
MKR81_RS20380	COG1704	LemA family
MKR81_RS20385	COG0501	Belongs to the peptidase M48B family
MKR81_RS20410	COG0641	radical SAM
MKR81_RS20430	COG3111	PFAM Bacterial OB fold (BOF) protein
MKR81_RS20435	COG1597	lipid kinase activity
MKR81_RS20440	COG0583	DNA-binding transcription factor activity
MKR81_RS20455	COG0355	proton-transporting ATP synthase activity, rotational mechanism
MKR81_RS20465	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MKR81_RS20525	COG0714	Associated with various cellular activities
MKR81_RS20535	COG3119	arylsulfatase activity
MKR81_RS20540	COG3119	arylsulfatase activity
MKR81_RS20570	COG0784	Response regulator, receiver
MKR81_RS20570	COG2205	protein histidine kinase activity
MKR81_RS20570	COG2198	Histidine kinase
MKR81_RS20575	COG1879	ABC-type sugar transport system periplasmic component
MKR81_RS20585	COG0210	DNA helicase
MKR81_RS20590	COG1289	transmembrane transporter activity
MKR81_RS20620	COG0789	Transcriptional regulator
MKR81_RS20625	COG4604	ABC transporter, ATP-binding protein
MKR81_RS20630	COG4605	iron ion homeostasis
MKR81_RS20635	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MKR81_RS20640	COG4607	ABC-type enterochelin transport system periplasmic component
MKR81_RS20655	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
MKR81_RS20670	COG1609	Transcriptional regulator
MKR81_RS20675	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MKR81_RS20680	COG1879	ABC-type sugar transport system periplasmic component
MKR81_RS20685	COG1172	Belongs to the binding-protein-dependent transport system permease family
MKR81_RS20690	COG1129	ABC transporter
MKR81_RS20700	COG5001	Diguanylate cyclase
MKR81_RS20705	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MKR81_RS20710	COG1794	racemase activity, acting on amino acids and derivatives
MKR81_RS20735	COG0586	Pfam SNARE associated Golgi protein
MKR81_RS20775	COG2205	protein histidine kinase activity
MKR81_RS20775	COG0784	Response regulator, receiver
MKR81_RS20805	COG0330	HflC and HflK could
MKR81_RS20815	COG0517	IMP dehydrogenase activity
MKR81_RS20815	COG4175	Glycine betaine
MKR81_RS20820	COG4176	ABC-type proline glycine betaine transport system permease component
MKR81_RS20855	COG0402	S-adenosylhomocysteine deaminase activity
MKR81_RS20875	COG2885	chlorophyll binding
MKR81_RS20915	COG0455	bacterial-type flagellum organization
MKR81_RS20925	COG4964	Belongs to the GSP D family
MKR81_RS20945	COG0583	DNA-binding transcription factor activity
MKR81_RS20950	COG1073	alpha beta
MKR81_RS20970	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
MKR81_RS20970	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
MKR81_RS20985	COG4989	oxidoreductase activity
MKR81_RS21010	COG1914	H( )-stimulated, divalent metal cation uptake system
MKR81_RS21025	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MKR81_RS21085	COG2897	thiosulfate sulfurtransferase activity
MKR81_RS21110	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
MKR81_RS21115	COG0840	transmembrane signaling receptor activity
MKR81_RS21120	COG2814	Major facilitator Superfamily
MKR81_RS21125	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
MKR81_RS21140	COG1612	heme a metabolic process
MKR81_RS21165	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
MKR81_RS21170	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MKR81_RS21180	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MKR81_RS21190	COG1280	lysine exporter protein (LysE YggA)
MKR81_RS21210	COG0179	Fumarylacetoacetate (FAA) hydrolase
MKR81_RS21225	COG0697	spore germination
MKR81_RS21240	COG2814	Major facilitator Superfamily
MKR81_RS21245	COG0583	DNA-binding transcription factor activity
MKR81_RS21250	COG5001	Diguanylate cyclase
MKR81_RS21255	COG0739	heme binding
MKR81_RS21275	COG3314	Sporulation integral membrane protein YlbJ
MKR81_RS21290	COG0814	amino acid
MKR81_RS21310	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
MKR81_RS21315	COG1072	(Pantothenic acid kinase))
MKR81_RS21325	COG1063	alcohol dehydrogenase
MKR81_RS21330	COG2213	PTS system mannitol-specific
MKR81_RS21335	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MKR81_RS21350	COG1733	regulation of RNA biosynthetic process
MKR81_RS21365	COG0798	PFAM Bile acid sodium symporter
MKR81_RS21380	COG1881	PFAM PEBP family protein
MKR81_RS21390	COG0251	oxidation-reduction process
MKR81_RS21395	COG2706	6-phosphogluconolactonase activity
MKR81_RS21405	COG0800	Aldolase
MKR81_RS21410	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MKR81_RS21415	COG4145	pantothenate transmembrane transporter activity
MKR81_RS21425	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
MKR81_RS21450	COG1131	(ABC) transporter
MKR81_RS21455	COG0842	Transport permease protein
MKR81_RS21475	COG3383	formate dehydrogenase (NAD+) activity
MKR81_RS21495	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MKR81_RS21540	COG0494	nUDIX hydrolase
MKR81_RS21555	COG1858	cytochrome C peroxidase
MKR81_RS21565	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MKR81_RS21570	COG2067	long-chain fatty acid transport protein
MKR81_RS21575	COG1505	serine-type exopeptidase activity
MKR81_RS21580	COG0488	(ABC) transporter
MKR81_RS21590	COG0589	response to stress
MKR81_RS21600	COG0584	glycerophosphoryl diester phosphodiesterase
MKR81_RS21610	COG1175	transmembrane transport
MKR81_RS21615	COG0395	ABC-type sugar transport system, permease component
MKR81_RS21620	COG3842	ATPase activity
MKR81_RS21635	COG0523	cobalamin synthesis protein
MKR81_RS21645	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MKR81_RS21655	COG4667	esterase of the alpha-beta hydrolase superfamily
MKR81_RS21660	COG1741	Belongs to the pirin family
MKR81_RS21665	COG1278	Cold shock
MKR81_RS21680	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
MKR81_RS21710	COG2226	methyltransferase
MKR81_RS21720	COG1686	Belongs to the peptidase S11 family
MKR81_RS21725	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MKR81_RS21730	COG0625	glutathione transferase activity
MKR81_RS21740	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MKR81_RS21780	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MKR81_RS21790	COG1940	carbohydrate kinase activity
MKR81_RS21795	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MKR81_RS21800	COG1737	Transcriptional regulator
MKR81_RS21815	COG0698	ribose 5-phosphate isomerase
MKR81_RS21820	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MKR81_RS21830	COG1028	Short-chain dehydrogenase reductase Sdr
MKR81_RS21855	COG3746	phosphate-selective porin O and P
MKR81_RS21880	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MKR81_RS21925	COG0513	Belongs to the DEAD box helicase family
MKR81_RS21930	COG0515	serine threonine protein kinase
MKR81_RS21930	COG1262	PFAM Formylglycine-generating sulfatase enzyme
MKR81_RS21955	COG0583	DNA-binding transcription factor activity
MKR81_RS21975	COG1028	Short-chain dehydrogenase reductase Sdr
MKR81_RS21985	COG1902	pentaerythritol trinitrate reductase activity
MKR81_RS21995	COG3853	Toxic anion resistance protein (TelA)
MKR81_RS22005	COG2255	four-way junction helicase activity
MKR81_RS22015	COG3122	Protein conserved in bacteria
MKR81_RS22020	COG2321	neutral zinc metallopeptidase
MKR81_RS22035	COG0583	DNA-binding transcription factor activity
MKR81_RS22040	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MKR81_RS22055	COG0252	asparaginase activity
MKR81_RS22065	COG0574	Belongs to the PEP-utilizing enzyme family
MKR81_RS22065	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MKR81_RS22075	COG2197	response regulator
MKR81_RS22080	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MKR81_RS22095	COG0583	DNA-binding transcription factor activity
MKR81_RS22100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MKR81_RS22110	COG1538	Outer membrane efflux protein
MKR81_RS22120	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
MKR81_RS22125	COG0786	glutamate:sodium symporter activity
MKR81_RS22155	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MKR81_RS22160	COG0318	PFAM AMP-dependent synthetase and ligase
MKR81_RS22230	COG4964	Belongs to the GSP D family
MKR81_RS22285	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MKR81_RS22295	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MKR81_RS22335	COG4948	Mandelate Racemase Muconate Lactonizing
MKR81_RS22360	COG1342	Belongs to the UPF0251 family
MKR81_RS22370	COG4176	ABC-type proline glycine betaine transport system permease component
MKR81_RS22375	COG3448	diguanylate cyclase activity
MKR81_RS22375	COG4175	Glycine betaine
MKR81_RS22395	COG0589	response to stress
MKR81_RS22400	COG0583	DNA-binding transcription factor activity
MKR81_RS22410	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
MKR81_RS22440	COG1335	isochorismatase
MKR81_RS22455	COG0753	catalase activity
MKR81_RS22470	COG1349	DNA-binding transcription factor activity
MKR81_RS22475	COG0346	lactoylglutathione lyase activity
MKR81_RS22480	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MKR81_RS22480	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MKR81_RS22490	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MKR81_RS22495	COG3537	Alpha-1,2-mannosidase
MKR81_RS22500	COG3537	Alpha-1,2-mannosidase
MKR81_RS22510	COG3537	Alpha-1,2-mannosidase
MKR81_RS22515	COG3537	Alpha-1,2-mannosidase
MKR81_RS22525	COG1280	lysine exporter protein (LysE YggA)
MKR81_RS22530	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MKR81_RS22545	COG4628	conserved protein (DUF2132)
MKR81_RS22550	COG0488	(ABC) transporter
MKR81_RS22565	COG0346	lactoylglutathione lyase activity
MKR81_RS22570	COG0384	phenazine biosynthesis protein PhzF
MKR81_RS22585	COG3220	belongs to the UPF0276 family
MKR81_RS22600	COG1271	oxidase subunit
MKR81_RS22605	COG1294	oxidase, subunit
MKR81_RS22645	COG1882	Formate acetyltransferase
MKR81_RS22650	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
MKR81_RS22655	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MKR81_RS22670	COG2205	protein histidine kinase activity
MKR81_RS22675	COG0745	RESPONSE REGULATOR receiver
MKR81_RS22685	COG0454	-acetyltransferase
MKR81_RS22690	COG0148	phosphopyruvate hydratase activity
MKR81_RS22700	COG2814	Major facilitator Superfamily
MKR81_RS22715	COG0583	DNA-binding transcription factor activity
MKR81_RS22720	COG2988	succinylglutamate desuccinylase activity
MKR81_RS22760	COG0628	permease
MKR81_RS22765	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
MKR81_RS22780	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MKR81_RS22790	COG4628	conserved protein (DUF2132)
MKR81_RS22795	COG0583	DNA-binding transcription factor activity
MKR81_RS22805	COG1686	Belongs to the peptidase S11 family
MKR81_RS22830	COG0415	Belongs to the DNA photolyase family
MKR81_RS22835	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
MKR81_RS22845	COG4667	esterase of the alpha-beta hydrolase superfamily
MKR81_RS22850	COG2095	MarC family integral membrane protein
MKR81_RS22865	COG1596	polysaccharide export
MKR81_RS22870	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MKR81_RS22905	COG1301	dicarboxylic acid transport
MKR81_RS22915	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MKR81_RS22920	COG0700	Nucleoside recognition
MKR81_RS22925	COG3366	ferrous iron transmembrane transporter activity
MKR81_RS22940	COG0366	Alpha amylase catalytic
MKR81_RS22945	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MKR81_RS22950	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
MKR81_RS22955	COG1640	4-alpha-glucanotransferase
MKR81_RS22960	COG0058	SHG alpha-glucan phosphorylase activity
MKR81_RS22980	COG1999	signal sequence binding
MKR81_RS23000	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
MKR81_RS23020	COG0531	amino acid
MKR81_RS23025	COG1982	Orn Lys Arg decarboxylase major
MKR81_RS23045	COG2356	endonuclease I
MKR81_RS23050	COG0366	Alpha amylase catalytic
MKR81_RS23070	COG4580	involved in the transport of maltose and maltodextrins
MKR81_RS23080	COG2199	diguanylate cyclase activity
MKR81_RS23080	COG2203	Gaf domain
MKR81_RS23110	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MKR81_RS23120	COG1760	l-serine dehydratase
MKR81_RS23145	COG1609	Transcriptional regulator
MKR81_RS23155	COG2814	Major facilitator Superfamily
MKR81_RS23170	COG0739	heme binding
MKR81_RS23185	COG0800	Aldolase
MKR81_RS23190	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MKR81_RS23195	COG1263	PTS System
MKR81_RS23195	COG2190	(PTS) system
MKR81_RS23195	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MKR81_RS23205	COG2188	Transcriptional regulator
MKR81_RS23230	COG3121	Chaperone
MKR81_RS23235	COG3188	usher protein
MKR81_RS23270	COG0612	Peptidase, M16
MKR81_RS23275	COG0840	transmembrane signaling receptor activity
MKR81_RS23285	COG0826	peptidase U32
MKR81_RS23315	COG0463	Glycosyl transferase, family 2
MKR81_RS23335	COG1335	isochorismatase
MKR81_RS23340	COG1136	(ABC) transporter
MKR81_RS23345	COG0577	efflux transmembrane transporter activity
MKR81_RS23395	COG1764	response to oxidative stress
MKR81_RS23400	COG1846	Transcriptional regulator
MKR81_RS23410	COG3634	alkyl hydroperoxide reductase activity
MKR81_RS23430	COG2610	gluconate transmembrane transporter activity
MKR81_RS23435	COG3622	Belongs to the hyi family
MKR81_RS23440	COG0235	Class ii aldolase
MKR81_RS23445	COG3395	kinase activity
MKR81_RS23450	COG2084	Dehydrogenase
MKR81_RS23455	COG1349	DNA-binding transcription factor activity
MKR81_RS23460	COG0583	DNA-binding transcription factor activity
MKR81_RS23465	COG0366	Alpha amylase catalytic
MKR81_RS23510	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
MKR81_RS23520	COG1522	sequence-specific DNA binding
MKR81_RS23525	COG0544	peptidyl-prolyl cis-trans isomerase activity
MKR81_RS23530	COG0544	peptidyl-prolyl cis-trans isomerase activity
MKR81_RS23545	COG2258	MOSC domain
MKR81_RS23550	COG2153	protein acetylation
MKR81_RS23565	COG1757	Na H antiporter
MKR81_RS23570	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
MKR81_RS23575	COG0513	Belongs to the DEAD box helicase family
MKR81_RS23580	COG1595	DNA-templated transcription, initiation
MKR81_RS23590	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
MKR81_RS23595	COG1312	Catalyzes the dehydration of D-mannonate
MKR81_RS23600	COG2186	Transcriptional regulator
MKR81_RS23610	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
MKR81_RS23620	COG0246	Mannitol dehydrogenase
MKR81_RS23625	COG1904	glucuronate isomerase
MKR81_RS23630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MKR81_RS23635	COG0800	Aldolase
MKR81_RS23675	COG1132	(ABC) transporter
MKR81_RS23795	COG4166	transmembrane transport
MKR81_RS23810	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
MKR81_RS23815	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MKR81_RS23815	COG1263	PTS System
MKR81_RS23820	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
MKR81_RS23845	COG1444	tRNA N-acetyltransferase activity
MKR81_RS23870	COG4608	Belongs to the ABC transporter superfamily
MKR81_RS23875	COG0444	Belongs to the ABC transporter superfamily
MKR81_RS23885	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MKR81_RS23885	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
MKR81_RS23910	COG0772	Belongs to the SEDS family
MKR81_RS23920	COG1566	PFAM secretion protein HlyD family protein
MKR81_RS23925	COG0583	DNA-binding transcription factor activity
MKR81_RS23935	COG1136	(ABC) transporter
MKR81_RS23955	COG3275	phosphorelay sensor kinase activity
MKR81_RS23960	COG3279	Response regulator of the LytR AlgR family
MKR81_RS23970	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MKR81_RS23990	COG0786	glutamate:sodium symporter activity
MKR81_RS24030	COG1131	(ABC) transporter
MKR81_RS24035	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MKR81_RS24040	COG0786	glutamate:sodium symporter activity
MKR81_RS24070	COG2259	Doxx family
MKR81_RS24080	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
MKR81_RS24085	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MKR81_RS24095	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MKR81_RS24140	COG2199	diguanylate cyclase activity
MKR81_RS24140	COG2200	EAL domain
MKR81_RS24140	COG2202	Pas domain
MKR81_RS24175	COG2885	chlorophyll binding
MKR81_RS24180	COG1858	cytochrome C peroxidase
MKR81_RS24185	COG0745	RESPONSE REGULATOR receiver
MKR81_RS24200	COG0642	Histidine kinase
MKR81_RS24220	COG5001	Diguanylate cyclase
MKR81_RS24235	COG1609	Transcriptional regulator
MKR81_RS24250	COG0395	ABC-type sugar transport system, permease component
MKR81_RS24255	COG2723	6-phospho-beta-galactosidase activity
MKR81_RS24260	COG3842	ATPase activity
MKR81_RS24265	COG1609	Transcriptional regulator
MKR81_RS24275	COG0747	negative chemotaxis
MKR81_RS24285	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MKR81_RS24290	COG0444	Belongs to the ABC transporter superfamily
MKR81_RS24295	COG4608	Belongs to the ABC transporter superfamily
MKR81_RS24305	COG1609	Transcriptional regulator
MKR81_RS24325	COG1472	Belongs to the glycosyl hydrolase 3 family
MKR81_RS24330	COG0534	Mate efflux family protein
MKR81_RS24335	COG0564	pseudouridine synthase activity
MKR81_RS24340	COG0561	phosphatase activity
MKR81_RS24360	COG3152	Membrane
MKR81_RS24375	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
MKR81_RS24400	COG0583	DNA-binding transcription factor activity
MKR81_RS24415	COG2270	Major facilitator Superfamily
MKR81_RS24450	COG2076	Multidrug Resistance protein
MKR81_RS24465	COG0534	Mate efflux family protein
MKR81_RS24480	COG1357	PFAM Pentapeptide repeats (8 copies)
MKR81_RS24485	COG3047	cAMP biosynthetic process
MKR81_RS24495	COG2814	Major facilitator Superfamily
MKR81_RS24515	COG3408	Glycogen debranching enzyme
MKR81_RS24515	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
MKR81_RS24605	COG3835	regulator
MKR81_RS24610	COG1929	Belongs to the glycerate kinase type-1 family
MKR81_RS24615	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MKR81_RS24655	COG0456	acetyltransferase
MKR81_RS24675	COG1028	Short-chain dehydrogenase reductase Sdr
MKR81_RS24685	COG3005	denitrification pathway
MKR81_RS24690	COG0243	molybdopterin cofactor binding
MKR81_RS24695	COG0671	phosphoesterase, PA-phosphatase related
MKR81_RS24710	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
MKR81_RS24715	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MKR81_RS24720	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MKR81_RS24725	COG1116	anion transmembrane transporter activity
MKR81_RS24730	COG0351	phosphomethylpyrimidine kinase
MKR81_RS24735	COG0312	modulator of DNA gyrase
MKR81_RS24740	COG0312	modulator of DNA gyrase
MKR81_RS24800	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MKR81_RS24810	COG0584	glycerophosphoryl diester phosphodiesterase
MKR81_RS24815	COG0745	RESPONSE REGULATOR receiver
MKR81_RS24835	COG0811	peptide transport
MKR81_RS24840	COG0811	peptide transport
MKR81_RS24845	COG0848	biopolymer transport protein
MKR81_RS24890	COG0803	Belongs to the bacterial solute-binding protein 9 family
MKR81_RS24895	COG1121	(ABC) transporter
MKR81_RS24900	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MKR81_RS24915	COG1770	oligopeptidase
MKR81_RS24920	COG2814	Major facilitator Superfamily
MKR81_RS24925	COG0010	Belongs to the arginase family
MKR81_RS24930	COG1166	arginine decarboxylase activity
MKR81_RS24940	COG0189	ligase activity
MKR81_RS24940	COG4067	protein conserved in archaea
MKR81_RS24945	COG0189	ligase activity
MKR81_RS24950	COG0583	DNA-binding transcription factor activity
MKR81_RS24995	COG1114	Component of the transport system for branched-chain amino acids
MKR81_RS25010	COG0579	oxidoreductase
MKR81_RS25015	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
MKR81_RS25030	COG3033	Beta-eliminating lyase
MKR81_RS25045	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MKR81_RS25050	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MKR81_RS25085	COG3706	GGDEF domain
MKR81_RS25090	COG0415	Belongs to the DNA photolyase family
MKR81_RS25095	COG3046	protein related to deoxyribodipyrimidine photolyase
MKR81_RS25110	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MKR81_RS25110	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MKR81_RS25115	COG1765	OsmC-like protein
MKR81_RS25150	COG1011	Hydrolase
MKR81_RS25175	COG3240	lipase activity
MKR81_RS25195	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MKR81_RS25205	COG1840	ABC-type Fe3 transport system, periplasmic component
MKR81_RS25210	COG3842	ATPase activity
MKR81_RS25235	COG2990	Protein conserved in bacteria
MKR81_RS25245	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MKR81_RS25250	COG2866	Carboxypeptidase
MKR81_RS25260	COG0583	DNA-binding transcription factor activity
MKR81_RS25285	COG3104	oligopeptide transport
MKR81_RS25290	COG1760	l-serine dehydratase
MKR81_RS25315	COG1388	LysM domain
MKR81_RS25315	COG0741	lytic transglycosylase activity
MKR81_RS25335	COG1815	bacterial-type flagellum-dependent cell motility
MKR81_RS25340	COG1558	bacterial-type flagellum-dependent cell motility
MKR81_RS25345	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
MKR81_RS25350	COG1749	Flagellar hook protein flgE
MKR81_RS25355	COG4787	bacterial-type flagellum-dependent cell motility
MKR81_RS25360	COG4786	Flagellar basal body rod
MKR81_RS25365	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
MKR81_RS25370	COG1706	bacterial-type flagellum-dependent cell motility
MKR81_RS25380	COG1256	bacterial-type flagellum assembly
MKR81_RS25380	COG4786	Flagellar basal body rod
MKR81_RS25385	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MKR81_RS25450	COG0384	phenazine biosynthesis protein PhzF
MKR81_RS25475	COG1360	Flagellar Motor Protein
MKR81_RS25480	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
MKR81_RS25485	COG1191	sigma factor activity
MKR81_RS25490	COG1580	Controls the rotational direction of flagella during chemotaxis
MKR81_RS25505	COG1516	flagellar protein fliS
MKR81_RS25510	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
MKR81_RS25520	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MKR81_RS25535	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
MKR81_RS25545	COG1987	bacterial-type flagellum assembly
MKR81_RS25605	COG2200	EAL domain
MKR81_RS25690	COG0346	lactoylglutathione lyase activity
MKR81_RS25715	COG0745	RESPONSE REGULATOR receiver
MKR81_RS25740	COG0156	8-amino-7-oxononanoate synthase activity
MKR81_RS25745	COG1063	alcohol dehydrogenase
MKR81_RS25770	COG2203	Gaf domain
MKR81_RS25770	COG2199	diguanylate cyclase activity
MKR81_RS25775	COG2223	nitrite transmembrane transporter activity
MKR81_RS25780	COG1063	alcohol dehydrogenase
MKR81_RS25790	COG0668	transmembrane transport
MKR81_RS25800	COG1304	FMN binding
MKR81_RS25805	COG1620	l-lactate permease
MKR81_RS25810	COG0583	DNA-binding transcription factor activity
MKR81_RS25815	COG1505	serine-type exopeptidase activity
MKR81_RS25820	COG4172	Belongs to the ABC transporter superfamily
MKR81_RS25830	COG1067	ATP-dependent peptidase activity
MKR81_RS25840	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
MKR81_RS25860	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MKR81_RS25865	COG0437	4 iron, 4 sulfur cluster binding
MKR81_RS25870	COG0348	domain, Protein
MKR81_RS25895	COG1122	ATPase activity
MKR81_RS25905	COG1566	PFAM secretion protein HlyD family protein
MKR81_RS25935	COG0813	purine-nucleoside phosphorylase activity
MKR81_RS25940	COG3272	Protein of unknown function (DUF1722)
MKR81_RS25945	COG0789	Transcriptional regulator
MKR81_RS25950	COG0415	Belongs to the DNA photolyase family
MKR81_RS25955	COG1388	LysM domain
MKR81_RS25955	COG1376	ErfK ybiS ycfS ynhG family protein
MKR81_RS25965	COG0513	Belongs to the DEAD box helicase family
MKR81_RS25975	COG1770	oligopeptidase
MKR81_RS25980	COG4771	TonB-dependent receptor
MKR81_RS26000	COG0840	transmembrane signaling receptor activity
MKR81_RS26010	COG0573	inorganic phosphate transmembrane transporter activity
MKR81_RS26035	COG0577	efflux transmembrane transporter activity
MKR81_RS26035	COG1136	(ABC) transporter
MKR81_RS26040	COG1136	(ABC) transporter
MKR81_RS26085	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
MKR81_RS26100	COG4974	Belongs to the 'phage' integrase family
MKR81_RS26105	COG0517	IMP dehydrogenase activity
MKR81_RS26135	COG2076	Multidrug Resistance protein
MKR81_RS26210	COG0776	regulation of translation
MKR81_RS26330	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
MKR81_RS26465	COG1879	ABC-type sugar transport system periplasmic component
MKR81_RS26470	COG0745	RESPONSE REGULATOR receiver
MKR81_RS26525	COG1988	membrane-bound metal-dependent
MKR81_RS26550	COG4232	protein-disulfide reductase activity
MKR81_RS26640	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MKR81_RS26655	COG0754	glutathionylspermidine amidase activity
MKR81_RS26690	COG0338	D12 class N6 adenine-specific DNA methyltransferase
MKR81_RS26740	COG4974	Belongs to the 'phage' integrase family
MKR81_RS26850	COG2885	chlorophyll binding
MKR81_RS26960	COG0616	signal peptide processing
MKR81_RS27135	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MKR81_RS27245	COG0210	DNA helicase
MKR81_RS27250	COG2353	YceI-like domain
MKR81_RS27295	COG0592	DNA-directed DNA polymerase activity
MKR81_RS27315	COG3141	response to X-ray
MKR81_RS27425	COG5295	Hep Hag repeat protein
MKR81_RS27515	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MKR81_RS27615	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
MKR81_RS27630	COG1737	Transcriptional regulator
MKR81_RS27645	COG3069	C4-dicarboxylate transmembrane transporter activity
MKR81_RS27650	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MKR81_RS27820	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MKR81_RS27845	COG3015	lipoprotein NlpE involved in copper resistance
MKR81_RS27960	COG2261	transglycosylase associated protein
MKR81_RS27995	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
MKR81_RS28035	COG3081	Nucleoid-associated protein
MKR81_RS28090	COG1192	Involved in chromosome partitioning
MKR81_RS28130	COG2003	Belongs to the UPF0758 family
MKR81_RS28150	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
MKR81_RS28190	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MKR81_RS28225	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
MKR81_RS28400	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
MKR81_RS28410	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MKR81_RS28415	COG0732	type I restriction modification DNA specificity domain
MKR81_RS28420	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
MKR81_RS28470	COG1192	Involved in chromosome partitioning
MKR81_RS28510	COG2026	Addiction module toxin, RelE StbE family
MKR81_RS28545	COG5268	conjugation
MKR81_RS28550	COG3451	type IV secretory pathway VirB4
MKR81_RS28560	COG4962	Type ii secretion system protein e
MKR81_RS28570	COG3701	Conjugal transfer protein
MKR81_RS28575	COG2026	Addiction module toxin, RelE StbE family
MKR81_RS28615	COG1192	Involved in chromosome partitioning
MKR81_RS28675	COG1403	HNH endonuclease