locus-tag	class	description
VCASEI_RS00005	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VCASEI_RS00010	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
VCASEI_RS00015	COG0706	membrane insertase activity
VCASEI_RS00020	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
VCASEI_RS00030	COG0230	Belongs to the bacterial ribosomal protein bL34 family
VCASEI_RS00035	COG1126	abc transporter atp-binding protein
VCASEI_RS00055	COG0592	DNA-directed DNA polymerase activity
VCASEI_RS00060	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
VCASEI_RS00065	COG0187	DNA topoisomerase II activity
VCASEI_RS00070	COG0071	Belongs to the small heat shock protein (HSP20) family
VCASEI_RS00075	COG3977	Valine--pyruvate aminotransferase
VCASEI_RS00090	COG0752	glycyl-tRNA synthetase alpha subunit
VCASEI_RS00095	COG1971	Probably functions as a manganese efflux pump
VCASEI_RS00105	COG0425	Belongs to the sulfur carrier protein TusA family
VCASEI_RS00110	COG1965	Belongs to the frataxin family
VCASEI_RS00120	COG0019	diaminopimelate decarboxylase activity
VCASEI_RS00125	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
VCASEI_RS00135	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
VCASEI_RS00140	COG1011	Hydrolase
VCASEI_RS00150	COG3148	PFAM DTW domain containing protein
VCASEI_RS00165	COG0561	phosphatase activity
VCASEI_RS00170	COG2267	carboxylic ester hydrolase activity
VCASEI_RS00200	COG0742	ribosomal rna small subunit methyltransferase
VCASEI_RS00205	COG0552	protein localization to endoplasmic reticulum
VCASEI_RS00210	COG2884	Cell division ATP-binding protein ftsE
VCASEI_RS00215	COG2177	Part of the ABC transporter FtsEX involved in
VCASEI_RS00230	COG0705	Rhomboid family
VCASEI_RS00235	COG3161	chorismate lyase activity
VCASEI_RS00240	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
VCASEI_RS00245	COG2937	Belongs to the GPAT DAPAT family
VCASEI_RS00250	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
VCASEI_RS00260	COG0534	Mate efflux family protein
VCASEI_RS00265	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VCASEI_RS00275	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VCASEI_RS00280	COG4206	TonB-dependent receptor
VCASEI_RS00285	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
VCASEI_RS00290	COG0724	RNA recognition motif
VCASEI_RS00335	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VCASEI_RS00345	COG0812	UDP-N-acetylmuramate dehydrogenase activity
VCASEI_RS00355	COG1072	(Pantothenic acid kinase))
VCASEI_RS00380	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VCASEI_RS00385	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VCASEI_RS00390	COG0250	Participates in transcription elongation, termination and antitermination
VCASEI_RS00400	COG0081	regulation of translation
VCASEI_RS00405	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
VCASEI_RS00410	COG0222	ribosome binding
VCASEI_RS00415	COG0085	RNA polymerase activity
VCASEI_RS00430	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
VCASEI_RS00435	COG2816	NAD+ diphosphatase activity
VCASEI_RS00450	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VCASEI_RS00465	COG1573	uracil-dna glycosylase
VCASEI_RS00490	COG0151	Belongs to the GarS family
VCASEI_RS00495	COG0138	bifunctional purine biosynthesis protein purh
VCASEI_RS00505	COG1609	Transcriptional regulator
VCASEI_RS00510	COG1263	PTS System
VCASEI_RS00510	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VCASEI_RS00515	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
VCASEI_RS00540	COG1263	PTS System
VCASEI_RS00540	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VCASEI_RS00540	COG2190	(PTS) system
VCASEI_RS00545	COG1609	Transcriptional regulator
VCASEI_RS00550	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
VCASEI_RS00560	COG2264	protein methyltransferase activity
VCASEI_RS00565	COG4145	pantothenate transmembrane transporter activity
VCASEI_RS00570	COG3924	membrane
VCASEI_RS00575	COG0439	Biotin carboxylase
VCASEI_RS00580	COG0511	ligase activity, forming carbon-carbon bonds
VCASEI_RS00585	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
VCASEI_RS00595	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VCASEI_RS00610	COG2814	Major facilitator Superfamily
VCASEI_RS00615	COG2202	Pas domain
VCASEI_RS00615	COG2205	protein histidine kinase activity
VCASEI_RS00625	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VCASEI_RS00635	COG2095	MarC family integral membrane protein
VCASEI_RS00640	COG3263	regulation of cellular component size
VCASEI_RS00650	COG4232	protein-disulfide reductase activity
VCASEI_RS00655	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VCASEI_RS00660	COG1027	Aspartate ammonia-lyase
VCASEI_RS00670	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
VCASEI_RS00675	COG2205	protein histidine kinase activity
VCASEI_RS00680	COG0745	RESPONSE REGULATOR receiver
VCASEI_RS00685	COG3678	ATP-independent chaperone mediated protein folding
VCASEI_RS00690	COG2962	Rard protein
VCASEI_RS00695	COG0514	ATP-dependent DNA helicase (RecQ)
VCASEI_RS00705	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
VCASEI_RS00710	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VCASEI_RS00710	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VCASEI_RS00740	COG2200	EAL domain
VCASEI_RS00745	COG2204	response regulator
VCASEI_RS00750	COG3852	Histidine kinase
VCASEI_RS00760	COG0174	glutamine synthetase
VCASEI_RS00765	COG1217	gtp-binding protein TYPA
VCASEI_RS00775	COG1490	D-aminoacyl-tRNA deacylase activity
VCASEI_RS00780	COG0456	acetyltransferase
VCASEI_RS00790	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
VCASEI_RS00795	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
VCASEI_RS00800	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
VCASEI_RS00805	COG3031	protein transport across the cell outer membrane
VCASEI_RS00815	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VCASEI_RS00820	COG1459	type II secretion system
VCASEI_RS00825	COG2165	general secretion pathway protein
VCASEI_RS00830	COG2165	general secretion pathway protein
VCASEI_RS00835	COG2165	general secretion pathway protein
VCASEI_RS00840	COG4795	General secretion pathway protein
VCASEI_RS00845	COG3156	type II secretion system protein K
VCASEI_RS00850	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VCASEI_RS00855	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VCASEI_RS00865	COG0494	nUDIX hydrolase
VCASEI_RS00870	COG1218	3'(2'),5'-bisphosphate nucleotidase
VCASEI_RS00890	COG1349	DNA-binding transcription factor activity
VCASEI_RS00895	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
VCASEI_RS00900	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
VCASEI_RS00910	COG2271	Major facilitator Superfamily
VCASEI_RS00915	COG0584	glycerophosphoryl diester phosphodiesterase
VCASEI_RS00925	COG2183	response to ionizing radiation
VCASEI_RS00930	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VCASEI_RS00975	COG2020	methyltransferase activity
VCASEI_RS00980	COG1012	belongs to the aldehyde dehydrogenase family
VCASEI_RS00985	COG0371	Dehydrogenase
VCASEI_RS01010	COG1136	(ABC) transporter
VCASEI_RS01025	COG1309	transcriptional regulator
VCASEI_RS01040	COG1201	RNA secondary structure unwinding
VCASEI_RS01075	COG3436	PFAM IS66 Orf2 family protein
VCASEI_RS01105	COG3436	PFAM IS66 Orf2 family protein
VCASEI_RS01115	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VCASEI_RS01135	COG3436	PFAM IS66 Orf2 family protein
VCASEI_RS01170	COG2233	PERMEase
VCASEI_RS01175	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
VCASEI_RS01180	COG1560	Kdo2-lipid A biosynthetic process
VCASEI_RS01185	COG1309	transcriptional regulator
VCASEI_RS01190	COG0756	dUTP diphosphatase activity
VCASEI_RS01195	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
VCASEI_RS01200	COG2003	Belongs to the UPF0758 family
VCASEI_RS01205	COG0227	Belongs to the bacterial ribosomal protein bL28 family
VCASEI_RS01210	COG0267	Belongs to the bacterial ribosomal protein bL33 family
VCASEI_RS01220	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
VCASEI_RS01240	COG0463	Glycosyl transferase, family 2
VCASEI_RS01245	COG0859	PFAM glycosyl transferase family 9
VCASEI_RS01250	COG3642	lipopolysaccharide core region biosynthetic process
VCASEI_RS01255	COG1045	serine acetyltransferase
VCASEI_RS01260	COG1519	Transferase
VCASEI_RS01265	COG0859	PFAM glycosyl transferase family 9
VCASEI_RS01275	COG0438	transferase activity, transferring glycosyl groups
VCASEI_RS01280	COG1560	Kdo2-lipid A biosynthetic process
VCASEI_RS01300	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
VCASEI_RS01305	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
VCASEI_RS01335	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VCASEI_RS01355	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
VCASEI_RS01400	COG1216	Glycosyl transferase, family 2
VCASEI_RS01475	COG0489	protein tyrosine kinase activity
VCASEI_RS01475	COG3206	protein involved in exopolysaccharide biosynthesis
VCASEI_RS01480	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VCASEI_RS01490	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VCASEI_RS01525	COG3706	GGDEF domain
VCASEI_RS01530	COG4942	peptidase
VCASEI_RS01535	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
VCASEI_RS01540	COG3547	Transposase (IS116 IS110 IS902 family)
VCASEI_RS01545	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VCASEI_RS01555	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
VCASEI_RS01560	COG1045	serine acetyltransferase
VCASEI_RS01585	COG4964	Belongs to the GSP D family
VCASEI_RS01620	COG0534	Mate efflux family protein
VCASEI_RS01645	COG1119	ATPase activity
VCASEI_RS01650	COG1285	pathogenesis
VCASEI_RS01655	COG0604	alcohol dehydrogenase
VCASEI_RS01665	COG1509	lysine 2,3-aminomutase activity
VCASEI_RS01670	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VCASEI_RS01695	COG0803	Belongs to the bacterial solute-binding protein 9 family
VCASEI_RS01705	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
VCASEI_RS01710	COG1053	succinate dehydrogenase
VCASEI_RS01720	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
VCASEI_RS01735	COG0688	phosphatidylethanolamine metabolic process
VCASEI_RS01740	COG1162	GTPase activity
VCASEI_RS01745	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
VCASEI_RS01795	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
VCASEI_RS01800	COG0802	atpase or kinase
VCASEI_RS01805	COG0860	N-Acetylmuramoyl-L-alanine amidase
VCASEI_RS01810	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
VCASEI_RS01815	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
VCASEI_RS01825	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
VCASEI_RS01830	COG0330	HflC and HflK could
VCASEI_RS01835	COG0330	HflC and HflK could
VCASEI_RS01840	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
VCASEI_RS01845	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
VCASEI_RS01850	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VCASEI_RS01850	COG1017	nitric oxide dioxygenase activity
VCASEI_RS01855	COG1959	2 iron, 2 sulfur cluster binding
VCASEI_RS01860	COG0557	exoribonuclease II activity
VCASEI_RS01865	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VCASEI_RS01870	COG0360	Binds together with S18 to 16S ribosomal RNA
VCASEI_RS01875	COG2965	DNA replication, synthesis of RNA primer
VCASEI_RS01900	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VCASEI_RS01915	COG0735	belongs to the Fur family
VCASEI_RS01950	COG4386	tail sheath protein
VCASEI_RS01990	COG4695	Portal protein
VCASEI_RS02035	COG3299	homolog of phage Mu protein gp47
VCASEI_RS02160	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VCASEI_RS02165	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VCASEI_RS02170	COG0175	sulfate reduction
VCASEI_RS02260	COG1566	PFAM secretion protein HlyD family protein
VCASEI_RS02280	COG1584	GPR1 FUN34 yaaH family protein
VCASEI_RS02285	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VCASEI_RS02295	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VCASEI_RS02305	COG1610	YqeY-like protein
VCASEI_RS02310	COG0828	Belongs to the bacterial ribosomal protein bS21 family
VCASEI_RS02315	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
VCASEI_RS02320	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
VCASEI_RS02325	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
VCASEI_RS02330	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VCASEI_RS02335	COG1968	undecaprenyl-diphosphatase activity
VCASEI_RS02340	COG0617	tRNA 3'-terminal CCA addition
VCASEI_RS02345	COG3267	Type II secretory pathway component ExeA
VCASEI_RS02345	COG3409	Peptidoglycan-binding domain 1 protein
VCASEI_RS02355	COG2233	PERMEase
VCASEI_RS02360	COG4991	sh3 domain protein
VCASEI_RS02365	COG0306	phosphate transporter
VCASEI_RS02370	COG1392	Phosphate transport regulator
VCASEI_RS02375	COG3025	triphosphatase activity
VCASEI_RS02380	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VCASEI_RS02385	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
VCASEI_RS02390	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
VCASEI_RS02390	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
VCASEI_RS02395	COG1538	Outer membrane efflux protein
VCASEI_RS02400	COG0494	nUDIX hydrolase
VCASEI_RS02405	COG3151	Protein conserved in bacteria
VCASEI_RS02415	COG3150	esterase
VCASEI_RS02420	COG0187	DNA topoisomerase II activity
VCASEI_RS02425	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
VCASEI_RS02435	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VCASEI_RS02440	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VCASEI_RS02445	COG3105	Protein conserved in bacteria
VCASEI_RS02450	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
VCASEI_RS02465	COG0723	plastoquinol--plastocyanin reductase activity
VCASEI_RS02470	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
VCASEI_RS02475	COG2857	Cytochrome c1
VCASEI_RS02480	COG0625	glutathione transferase activity
VCASEI_RS02485	COG2969	positive regulation of protein catabolic process
VCASEI_RS02500	COG0646	methionine synthase
VCASEI_RS02500	COG1410	methionine synthase
VCASEI_RS02505	COG0527	aspartate kinase activity
VCASEI_RS02510	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
VCASEI_RS02520	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
VCASEI_RS02535	COG0629	single-stranded DNA binding
VCASEI_RS02540	COG2199	diguanylate cyclase activity
VCASEI_RS02540	COG2200	EAL domain
VCASEI_RS02565	COG3267	Type II secretory pathway component ExeA
VCASEI_RS02565	COG3409	Peptidoglycan-binding domain 1 protein
VCASEI_RS02575	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VCASEI_RS02580	COG1459	type II secretion system
VCASEI_RS02600	COG2165	general secretion pathway protein
VCASEI_RS02605	COG4969	Belongs to the N-Me-Phe pilin family
VCASEI_RS02630	COG1077	Cell shape determining protein MreB Mrl
VCASEI_RS02640	COG1792	Involved in formation and maintenance of cell shape
VCASEI_RS02645	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
VCASEI_RS02650	COG0424	maF-like protein
VCASEI_RS02655	COG1530	ribonuclease E activity
VCASEI_RS02660	COG3164	Protein of unknown function
VCASEI_RS02665	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VCASEI_RS02670	COG0312	modulator of DNA gyrase
VCASEI_RS02675	COG3028	Belongs to the UPF0307 family
VCASEI_RS02680	COG0312	modulator of DNA gyrase
VCASEI_RS02685	COG2239	Acts as a magnesium transporter
VCASEI_RS02690	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VCASEI_RS02695	COG1660	Displays ATPase and GTPase activities
VCASEI_RS02700	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VCASEI_RS02715	COG1137	ATPase activity
VCASEI_RS02720	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
VCASEI_RS02730	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
VCASEI_RS02735	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
VCASEI_RS02735	COG0517	IMP dehydrogenase activity
VCASEI_RS02745	COG1127	ABC transporter
VCASEI_RS02750	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
VCASEI_RS02755	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VCASEI_RS02760	COG2854	intermembrane phospholipid transfer
VCASEI_RS02770	COG5007	Belongs to the BolA IbaG family
VCASEI_RS02775	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
VCASEI_RS02780	COG0204	Acyl-transferase
VCASEI_RS02785	COG0598	Magnesium transport protein CorA
VCASEI_RS02790	COG1846	Transcriptional regulator
VCASEI_RS02795	COG1566	PFAM secretion protein HlyD family protein
VCASEI_RS02800	COG2814	Major facilitator Superfamily
VCASEI_RS02805	COG3300	MHYT domain
VCASEI_RS02805	COG5001	Diguanylate cyclase
VCASEI_RS02815	COG0251	oxidation-reduction process
VCASEI_RS02825	COG0540	Belongs to the ATCase OTCase family
VCASEI_RS02830	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
VCASEI_RS02845	COG0456	acetyltransferase
VCASEI_RS02855	COG0525	valine-tRNA ligase activity
VCASEI_RS02860	COG2927	DNA polymerase III (CHI subunit)
VCASEI_RS02870	COG0795	lipopolysaccharide-transporting ATPase activity
VCASEI_RS02875	COG0795	lipopolysaccharide-transporting ATPase activity
VCASEI_RS02890	COG0463	Glycosyl transferase, family 2
VCASEI_RS02900	COG1012	belongs to the aldehyde dehydrogenase family
VCASEI_RS02955	COG0741	lytic transglycosylase activity
VCASEI_RS02960	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
VCASEI_RS02975	COG2066	Belongs to the glutaminase family
VCASEI_RS02980	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VCASEI_RS02985	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
VCASEI_RS03000	COG0762	integral membrane protein
VCASEI_RS03005	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
VCASEI_RS03010	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
VCASEI_RS03040	COG1678	Uncharacterized ACR, COG1678
VCASEI_RS03045	COG0189	ligase activity
VCASEI_RS03050	COG1385	rRNA (uridine-N3-)-methyltransferase activity
VCASEI_RS03055	COG3706	GGDEF domain
VCASEI_RS03060	COG3091	SprT-like family
VCASEI_RS03075	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VCASEI_RS03080	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VCASEI_RS03090	COG0191	fructose-bisphosphate aldolase activity
VCASEI_RS03095	COG0668	transmembrane transport
VCASEI_RS03105	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VCASEI_RS03115	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
VCASEI_RS03125	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
VCASEI_RS03130	COG3079	Belongs to the UPF0149 family
VCASEI_RS03135	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VCASEI_RS03140	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VCASEI_RS03150	COG0354	folic acid binding
VCASEI_RS03155	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
VCASEI_RS03165	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
VCASEI_RS03170	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
VCASEI_RS03175	COG1845	cytochrome c oxidase, subunit III
VCASEI_RS03180	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
VCASEI_RS03185	COG0109	protoheme IX farnesyltransferase activity
VCASEI_RS03200	COG3634	alkyl hydroperoxide reductase activity
VCASEI_RS03235	COG2867	negative regulation of translational initiation
VCASEI_RS03240	COG2914	Belongs to the UPF0125 (RnfH) family
VCASEI_RS03245	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VCASEI_RS03250	COG0497	DNA recombination
VCASEI_RS03255	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
VCASEI_RS03260	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
VCASEI_RS03265	COG0443	Heat shock 70 kDa protein
VCASEI_RS03270	COG0484	heat shock protein binding
VCASEI_RS03305	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
VCASEI_RS03310	COG0047	phosphoribosylformylglycinamidine synthase activity
VCASEI_RS03310	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
VCASEI_RS03325	COG0514	ATP-dependent DNA helicase (RecQ)
VCASEI_RS03370	COG0442	prolyl-tRNA aminoacylation
VCASEI_RS03375	COG1720	tRNA m6t6A37 methyltransferase activity
VCASEI_RS03380	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
VCASEI_RS03390	COG1464	Belongs to the NlpA lipoprotein family
VCASEI_RS03395	COG2011	ABC-type metal ion transport system permease component
VCASEI_RS03400	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
VCASEI_RS03405	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VCASEI_RS03410	COG4174	ABC transporter (Permease)
VCASEI_RS03415	COG4239	(ABC) transporter, permease
VCASEI_RS03420	COG0747	negative chemotaxis
VCASEI_RS03425	COG0444	Belongs to the ABC transporter superfamily
VCASEI_RS03430	COG4608	Belongs to the ABC transporter superfamily
VCASEI_RS03455	COG0084	hydrolase, TatD family'
VCASEI_RS03460	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VCASEI_RS03465	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
VCASEI_RS03470	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
VCASEI_RS03475	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
VCASEI_RS03480	COG0813	purine-nucleoside phosphorylase activity
VCASEI_RS03490	COG0560	Phosphoserine phosphatase
VCASEI_RS03495	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
VCASEI_RS03500	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VCASEI_RS03505	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VCASEI_RS03510	COG4628	conserved protein (DUF2132)
VCASEI_RS03515	COG1022	Amp-dependent synthetase and ligase
VCASEI_RS03535	COG1929	Belongs to the glycerate kinase type-1 family
VCASEI_RS03540	COG2610	gluconate transmembrane transporter activity
VCASEI_RS03545	COG3835	regulator
VCASEI_RS03555	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
VCASEI_RS03560	COG2171	N-acyltransferase activity
VCASEI_RS03565	COG1584	GPR1 FUN34 yaaH family protein
VCASEI_RS03570	COG2095	MarC family integral membrane protein
VCASEI_RS03575	COG3141	response to X-ray
VCASEI_RS03585	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
VCASEI_RS03590	COG1074	ATP-dependent DNA helicase activity
VCASEI_RS03595	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
VCASEI_RS03600	COG2731	YhcH YjgK YiaL family protein
VCASEI_RS03605	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VCASEI_RS03605	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VCASEI_RS03610	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
VCASEI_RS03615	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
VCASEI_RS03620	COG2166	iron-sulfur cluster assembly
VCASEI_RS03625	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VCASEI_RS03630	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
VCASEI_RS03635	COG3248	Nucleoside-binding outer membrane protein
VCASEI_RS03645	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VCASEI_RS03660	COG0271	Belongs to the BolA IbaG family
VCASEI_RS03665	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VCASEI_RS03670	COG1805	sodium ion transport
VCASEI_RS03685	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VCASEI_RS03690	COG2871	sodium ion transport
VCASEI_RS03695	COG1477	protein flavinylation
VCASEI_RS03715	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
VCASEI_RS03720	COG2195	Cleaves the N-terminal amino acid of tripeptides
VCASEI_RS03725	COG2252	PERMEase
VCASEI_RS03730	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
VCASEI_RS03740	COG1073	alpha beta
VCASEI_RS03775	COG1686	Belongs to the peptidase S11 family
VCASEI_RS03780	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
VCASEI_RS03785	COG0772	Belongs to the SEDS family
VCASEI_RS03790	COG0768	penicillin binding
VCASEI_RS03795	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
VCASEI_RS03800	COG0799	negative regulation of ribosome biogenesis
VCASEI_RS03805	COG1466	dna polymerase III delta subunit
VCASEI_RS03810	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
VCASEI_RS03815	COG0495	leucyl-tRNA aminoacylation
VCASEI_RS03820	COG2888	peptidyl-tyrosine sulfation
VCASEI_RS03825	COG0815	Transfers the fatty acyl group on membrane lipoproteins
VCASEI_RS03830	COG4535	Mg2 and Co2 transporter CorC
VCASEI_RS03835	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
VCASEI_RS03840	COG1702	phosphate starvation-inducible protein PhoH
VCASEI_RS03845	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VCASEI_RS03850	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VCASEI_RS03860	COG2706	6-phosphogluconolactonase activity
VCASEI_RS03925	COG0193	aminoacyl-tRNA hydrolase activity
VCASEI_RS03930	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
VCASEI_RS03935	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
VCASEI_RS03945	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
VCASEI_RS03950	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
VCASEI_RS03955	COG2890	protein-(glutamine-N5) methyltransferase activity
VCASEI_RS03960	COG3094	Invasion gene expression up-regulator, SirB
VCASEI_RS03965	COG2912	Transglutaminase-like superfamily
VCASEI_RS03970	COG2877	3-deoxy-8-phosphooctulonate synthase activity
VCASEI_RS03980	COG0737	Belongs to the 5'-nucleotidase family
VCASEI_RS04000	COG1187	pseudouridine synthase activity
VCASEI_RS04005	COG2840	Smr protein MutS2
VCASEI_RS04020	COG2814	Major facilitator Superfamily
VCASEI_RS04040	COG2608	mercury ion transmembrane transporter activity
VCASEI_RS04040	COG2217	Heavy metal translocating P-type atpase
VCASEI_RS04055	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VCASEI_RS04075	COG0811	peptide transport
VCASEI_RS04080	COG0811	peptide transport
VCASEI_RS04085	COG0848	biopolymer transport protein
VCASEI_RS04100	COG3708	Transcriptional regulator
VCASEI_RS04100	COG2207	Transcriptional regulator
VCASEI_RS04120	COG0443	Heat shock 70 kDa protein
VCASEI_RS04155	COG3335	DDE superfamily endonuclease
VCASEI_RS04175	COG1028	Short-chain dehydrogenase reductase Sdr
VCASEI_RS04195	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VCASEI_RS04200	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VCASEI_RS04205	COG2267	carboxylic ester hydrolase activity
VCASEI_RS04220	COG4589	Belongs to the CDS family
VCASEI_RS04235	COG3335	DDE superfamily endonuclease
VCASEI_RS04255	COG0110	maltose O-acetyltransferase activity
VCASEI_RS04260	COG0488	(ABC) transporter
VCASEI_RS04270	COG4772	TonB-dependent receptor
VCASEI_RS04285	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
VCASEI_RS04290	COG1120	ATPase activity
VCASEI_RS04300	COG1132	(ABC) transporter
VCASEI_RS04330	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VCASEI_RS04330	COG0723	plastoquinol--plastocyanin reductase activity
VCASEI_RS04335	COG0300	oxidoreductase activity
VCASEI_RS04345	COG0415	Belongs to the DNA photolyase family
VCASEI_RS04360	COG1595	DNA-templated transcription, initiation
VCASEI_RS04365	COG4133	protoheme IX ABC transporter activity
VCASEI_RS04370	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VCASEI_RS04375	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VCASEI_RS04390	COG1138	Cytochrome C-type biogenesis protein
VCASEI_RS04395	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VCASEI_RS04415	COG2067	long-chain fatty acid transport protein
VCASEI_RS04425	COG1595	DNA-templated transcription, initiation
VCASEI_RS04430	COG0183	Belongs to the thiolase family
VCASEI_RS04435	COG1250	3-hydroxyacyl-CoA dehydrogenase
VCASEI_RS04435	COG1024	Enoyl-CoA hydratase
VCASEI_RS04445	COG1025	Belongs to the peptidase M16 family
VCASEI_RS04450	COG2062	phosphohistidine phosphatase, SixA
VCASEI_RS04455	COG2840	Smr protein MutS2
VCASEI_RS04460	COG2890	protein-(glutamine-N5) methyltransferase activity
VCASEI_RS04465	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
VCASEI_RS04475	COG5492	domain, Protein
VCASEI_RS04475	COG4932	domain protein
VCASEI_RS04480	COG2860	membrane
VCASEI_RS04485	COG3101	peptidyl-lysine hydroxylation
VCASEI_RS04500	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
VCASEI_RS04500	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VCASEI_RS04505	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VCASEI_RS04510	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VCASEI_RS04515	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VCASEI_RS04525	COG0101	tRNA pseudouridine synthase activity
VCASEI_RS04530	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
VCASEI_RS04535	COG0285	dihydrofolate synthase activity
VCASEI_RS04540	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
VCASEI_RS04545	COG1286	toxin biosynthetic process
VCASEI_RS04550	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
VCASEI_RS04555	COG0583	DNA-binding transcription factor activity
VCASEI_RS04560	COG0745	RESPONSE REGULATOR receiver
VCASEI_RS04565	COG2832	Protein of unknown function (DUF454)
VCASEI_RS04570	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
VCASEI_RS04575	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
VCASEI_RS04585	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
VCASEI_RS04595	COG2983	Belongs to the UPF0260 family
VCASEI_RS04610	COG2226	methyltransferase
VCASEI_RS04615	COG0676	glucose-6-phosphate 1-epimerase activity
VCASEI_RS04620	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VCASEI_RS04625	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VCASEI_RS04630	COG3139	Protein of unknown function (DUF1315)
VCASEI_RS04635	COG0252	asparaginase activity
VCASEI_RS04640	COG0616	signal peptide processing
VCASEI_RS04645	COG1902	pentaerythritol trinitrate reductase activity
VCASEI_RS04645	COG0446	pyridine nucleotide-disulphide oxidoreductase
VCASEI_RS04650	COG0778	Nitroreductase
VCASEI_RS04655	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VCASEI_RS04685	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VCASEI_RS04710	COG0515	serine threonine protein kinase
VCASEI_RS04710	COG2815	serine threonine protein kinase
VCASEI_RS04815	COG3083	sulfuric ester hydrolase activity
VCASEI_RS04820	COG3082	Protein of unknown function (DUF1414)
VCASEI_RS04825	COG3081	Nucleoid-associated protein
VCASEI_RS04830	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VCASEI_RS04840	COG2095	MarC family integral membrane protein
VCASEI_RS04855	COG1012	belongs to the aldehyde dehydrogenase family
VCASEI_RS04855	COG1454	alcohol dehydrogenase
VCASEI_RS04870	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
VCASEI_RS04880	COG2056	Na+-H+ antiporter family
VCASEI_RS04890	COG0346	lactoylglutathione lyase activity
VCASEI_RS04895	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
VCASEI_RS04900	COG4660	Part of a membrane complex involved in electron transport
VCASEI_RS04905	COG4659	FMN binding
VCASEI_RS04915	COG4656	Part of a membrane complex involved in electron transport
VCASEI_RS04925	COG4657	Part of a membrane complex involved in electron transport
VCASEI_RS04935	COG0556	nucleotide-excision repair
VCASEI_RS04940	COG0391	Required for morphogenesis under gluconeogenic growth conditions
VCASEI_RS04950	COG0521	Mo-molybdopterin cofactor biosynthetic process
VCASEI_RS04960	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
VCASEI_RS04965	COG0314	molybdopterin synthase activity
VCASEI_RS04985	COG0601	transmembrane transport
VCASEI_RS04990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VCASEI_RS05025	COG1653	transport
VCASEI_RS05030	COG1609	Transcriptional regulator
VCASEI_RS05035	COG4580	involved in the transport of maltose and maltodextrins
VCASEI_RS05045	COG1940	carbohydrate kinase activity
VCASEI_RS05050	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VCASEI_RS05055	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VCASEI_RS05060	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VCASEI_RS05060	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VCASEI_RS05065	COG2723	6-phospho-beta-galactosidase activity
VCASEI_RS05070	COG1447	Phosphotransferase system cellobiose-specific component IIA
VCASEI_RS05075	COG1609	Transcriptional regulator
VCASEI_RS05080	COG2723	6-phospho-beta-galactosidase activity
VCASEI_RS05085	COG0673	inositol 2-dehydrogenase activity
VCASEI_RS05120	COG0435	Glutathione S-transferase
VCASEI_RS05125	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VCASEI_RS05160	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VCASEI_RS05170	COG1522	sequence-specific DNA binding
VCASEI_RS05175	COG1946	Acyl-CoA thioesterase
VCASEI_RS05180	COG3126	Type III secretion system lipoprotein chaperone (YscW)
VCASEI_RS05230	COG1061	Type III restriction enzyme res subunit
VCASEI_RS05285	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
VCASEI_RS05310	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
VCASEI_RS05400	COG2249	NAD(P)H dehydrogenase (quinone) activity
VCASEI_RS05405	COG0583	DNA-binding transcription factor activity
VCASEI_RS05430	COG0697	spore germination
VCASEI_RS05445	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VCASEI_RS05445	COG3153	acetyltransferase
VCASEI_RS05450	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
VCASEI_RS05450	COG0617	tRNA 3'-terminal CCA addition
VCASEI_RS05450	COG0517	IMP dehydrogenase activity
VCASEI_RS05470	COG0537	adenosine 5'-monophosphoramidase activity
VCASEI_RS05495	COG3150	esterase
VCASEI_RS05500	COG1252	NADH dehydrogenase
VCASEI_RS05515	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
VCASEI_RS05520	COG4591	ABC-type transport system involved in lipoprotein release permease component
VCASEI_RS05525	COG1136	(ABC) transporter
VCASEI_RS05530	COG4591	ABC-type transport system involved in lipoprotein release permease component
VCASEI_RS05540	COG2333	competence protein COMEC
VCASEI_RS05540	COG0658	competence protein
VCASEI_RS05550	COG1663	tetraacyldisaccharide 4'-kinase activity
VCASEI_RS05555	COG2835	tetraacyldisaccharide 4'-kinase activity
VCASEI_RS05560	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
VCASEI_RS05610	COG1280	lysine exporter protein (LysE YggA)
VCASEI_RS05645	COG0789	Transcriptional regulator
VCASEI_RS05670	COG2719	SpoVR family
VCASEI_RS05675	COG2718	Belongs to the UPF0229 family
VCASEI_RS05680	COG2766	serine protein kinase
VCASEI_RS05685	COG3013	Belongs to the UPF0304 family
VCASEI_RS05690	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VCASEI_RS05700	COG3313	Fe-S protein
VCASEI_RS05715	COG0798	PFAM Bile acid sodium symporter
VCASEI_RS05720	COG1393	Belongs to the ArsC family
VCASEI_RS05725	COG0431	NADPH-dependent FMN reductase
VCASEI_RS05750	COG2801	Transposase and inactivated derivatives
VCASEI_RS05760	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VCASEI_RS05765	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
VCASEI_RS05770	COG1609	Transcriptional regulator
VCASEI_RS05775	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
VCASEI_RS05780	COG3265	gluconokinase activity
VCASEI_RS05795	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
VCASEI_RS05800	COG1061	Type III restriction enzyme res subunit
VCASEI_RS05805	COG1882	Formate acetyltransferase
VCASEI_RS05825	COG4160	amino acid transport
VCASEI_RS05830	COG0708	Exodeoxyribonuclease III
VCASEI_RS05835	COG2850	peptidyl-arginine hydroxylation
VCASEI_RS05840	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
VCASEI_RS05845	COG2915	High frequency lysogenization protein hflD homolog
VCASEI_RS05855	COG1187	pseudouridine synthase activity
VCASEI_RS05865	COG1278	Cold shock
VCASEI_RS05870	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
VCASEI_RS05875	COG0542	response to heat
VCASEI_RS05880	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
VCASEI_RS05885	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
VCASEI_RS05895	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
VCASEI_RS05905	COG0539	negative regulation of cytoplasmic translation
VCASEI_RS05910	COG0776	regulation of translation
VCASEI_RS05915	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
VCASEI_RS05920	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
VCASEI_RS05945	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
VCASEI_RS05950	COG4136	ATPase activity
VCASEI_RS05955	COG4135	transport system, permease component
VCASEI_RS05960	COG4134	Bacterial extracellular solute-binding protein
VCASEI_RS05965	COG1609	Transcriptional regulator
VCASEI_RS05970	COG1434	Gram-negative-bacterium-type cell wall biogenesis
VCASEI_RS05975	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VCASEI_RS05980	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
VCASEI_RS05985	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
VCASEI_RS06020	COG0471	metal ion transport
VCASEI_RS06030	COG4172	Belongs to the ABC transporter superfamily
VCASEI_RS06040	COG4171	peptide transport system, permease
VCASEI_RS06050	COG4166	transmembrane transport
VCASEI_RS06055	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
VCASEI_RS06060	COG1842	Phage shock protein A
VCASEI_RS06070	COG1983	PspC domain protein
VCASEI_RS06075	COG2818	Glycosylase
VCASEI_RS06080	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VCASEI_RS06095	COG0626	cystathionine gamma-synthase activity
VCASEI_RS06105	COG0733	neurotransmitter:sodium symporter activity
VCASEI_RS06110	COG0564	pseudouridine synthase activity
VCASEI_RS06115	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VCASEI_RS06130	COG2350	Protein conserved in bacteria
VCASEI_RS06140	COG2917	probably involved in intracellular septation
VCASEI_RS06155	COG0134	indole-3-glycerol-phosphate synthase activity
VCASEI_RS06155	COG0135	phosphoribosylanthranilate isomerase activity
VCASEI_RS06160	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
VCASEI_RS06165	COG0512	Glutamine amidotransferase of anthranilate synthase
VCASEI_RS06170	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VCASEI_RS06175	COG0613	PHP domain protein
VCASEI_RS06180	COG0009	L-threonylcarbamoyladenylate synthase
VCASEI_RS06195	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VCASEI_RS06200	COG0417	DNA replication proofreading
VCASEI_RS06205	COG2197	response regulator
VCASEI_RS06210	COG0322	excinuclease ABC activity
VCASEI_RS06245	COG1022	Amp-dependent synthetase and ligase
VCASEI_RS06300	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VCASEI_RS06305	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VCASEI_RS06310	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VCASEI_RS06320	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VCASEI_RS06345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VCASEI_RS06360	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
VCASEI_RS06385	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VCASEI_RS06400	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VCASEI_RS06405	COG1448	Aminotransferase
VCASEI_RS06420	COG1028	Short-chain dehydrogenase reductase Sdr
VCASEI_RS06430	COG2807	transmembrane transport
VCASEI_RS06440	COG1126	abc transporter atp-binding protein
VCASEI_RS06445	COG0765	amino acid transport
VCASEI_RS06450	COG4597	amino acid ABC transporter
VCASEI_RS06455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VCASEI_RS06465	COG4139	cobalamin transport
VCASEI_RS06470	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
VCASEI_RS06480	COG2814	Major facilitator Superfamily
VCASEI_RS06485	COG0583	DNA-binding transcription factor activity
VCASEI_RS06490	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VCASEI_RS06495	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VCASEI_RS06505	COG3040	lipid binding
VCASEI_RS06510	COG1187	pseudouridine synthase activity
VCASEI_RS06515	COG0513	Belongs to the DEAD box helicase family
VCASEI_RS06530	COG3122	Protein conserved in bacteria
VCASEI_RS06540	COG0625	glutathione transferase activity
VCASEI_RS06565	COG0351	phosphomethylpyrimidine kinase
VCASEI_RS06570	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
VCASEI_RS06585	COG1301	dicarboxylic acid transport
VCASEI_RS06600	COG0746	molybdenum cofactor guanylyltransferase activity
VCASEI_RS06610	COG4176	ABC-type proline glycine betaine transport system permease component
VCASEI_RS06620	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VCASEI_RS06625	COG1793	dna ligase
VCASEI_RS06630	COG0534	Mate efflux family protein
VCASEI_RS06640	COG3001	Fructosamine kinase
VCASEI_RS06645	COG0791	NLP P60 protein
VCASEI_RS06650	COG1940	carbohydrate kinase activity
VCASEI_RS06670	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
VCASEI_RS06680	COG1177	transmembrane transport
VCASEI_RS06685	COG1176	ABC-type spermidine putrescine transport system, permease component I
VCASEI_RS06690	COG3842	ATPase activity
VCASEI_RS06710	COG0037	tRNA processing
VCASEI_RS06715	COG0589	response to stress
VCASEI_RS06720	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VCASEI_RS06735	COG2217	Heavy metal translocating P-type atpase
VCASEI_RS06745	COG2010	Cytochrome c
VCASEI_RS06760	COG3278	Belongs to the heme-copper respiratory oxidase family
VCASEI_RS06770	COG1971	Probably functions as a manganese efflux pump
VCASEI_RS06775	COG2863	cytochrome
VCASEI_RS06785	COG1067	ATP-dependent peptidase activity
VCASEI_RS06790	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VCASEI_RS06805	COG0488	(ABC) transporter
VCASEI_RS06815	COG0116	Belongs to the methyltransferase superfamily
VCASEI_RS06815	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VCASEI_RS06830	COG0167	dihydroorotate dehydrogenase activity
VCASEI_RS06850	COG0308	aminopeptidase N
VCASEI_RS06865	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
VCASEI_RS06870	COG1956	GAF domain-containing protein
VCASEI_RS06880	COG2995	paraquat-inducible protein a
VCASEI_RS06885	COG3008	intermembrane lipid transfer
VCASEI_RS06895	COG3547	Transposase (IS116 IS110 IS902 family)
VCASEI_RS06910	COG3647	Membrane
VCASEI_RS06920	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
VCASEI_RS06935	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VCASEI_RS06940	COG1666	GTP binding
VCASEI_RS06950	COG1280	lysine exporter protein (LysE YggA)
VCASEI_RS06975	COG1643	Atp-dependent helicase
VCASEI_RS06990	COG0583	DNA-binding transcription factor activity
VCASEI_RS07010	COG4974	Belongs to the 'phage' integrase family
VCASEI_RS07050	COG2925	Exonuclease
VCASEI_RS07055	COG1380	Effector of murein hydrolase LrgA
VCASEI_RS07060	COG1346	cytolysis
VCASEI_RS07080	COG0776	regulation of translation
VCASEI_RS07090	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VCASEI_RS07090	COG0072	phenylalanine-tRNA ligase activity
VCASEI_RS07100	COG2133	pyrroloquinoline quinone binding
VCASEI_RS07105	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
VCASEI_RS07130	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VCASEI_RS07135	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
VCASEI_RS07150	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
VCASEI_RS07165	COG1126	abc transporter atp-binding protein
VCASEI_RS07170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VCASEI_RS07175	COG4215	(ABC) transporter
VCASEI_RS07180	COG4160	amino acid transport
VCASEI_RS07185	COG0277	FAD linked oxidase domain protein
VCASEI_RS07185	COG0247	lactate metabolic process
VCASEI_RS07200	COG2920	part of a sulfur-relay system
VCASEI_RS07205	COG1254	Belongs to the acylphosphatase family
VCASEI_RS07210	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VCASEI_RS07235	COG1280	lysine exporter protein (LysE YggA)
VCASEI_RS07240	COG1823	symporter activity
VCASEI_RS07265	COG0443	Heat shock 70 kDa protein
VCASEI_RS07280	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VCASEI_RS07285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VCASEI_RS07305	COG3264	Mechanosensitive ion channel
VCASEI_RS07305	COG1196	nuclear chromosome segregation
VCASEI_RS07340	COG2824	Alkylphosphonate utilization operon protein PhnA
VCASEI_RS07345	COG3768	UPF0283 membrane protein
VCASEI_RS07350	COG3106	COG3106 Predicted ATPase
VCASEI_RS07375	COG0814	amino acid
VCASEI_RS07380	COG1760	l-serine dehydratase
VCASEI_RS07395	COG0017	Asparaginyl-tRNA synthetase
VCASEI_RS07410	COG0670	Belongs to the BI1 family
VCASEI_RS07430	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
VCASEI_RS07435	COG0281	malic enzyme
VCASEI_RS07440	COG2949	membrane
VCASEI_RS07465	COG0492	ferredoxin-NADP+ reductase activity
VCASEI_RS07470	COG4988	ABC transporter
VCASEI_RS07475	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
VCASEI_RS07480	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
VCASEI_RS07495	COG3070	regulator of competence-specific genes
VCASEI_RS07500	COG2431	L-lysine efflux transmembrane transporter activity
VCASEI_RS07510	COG0076	glutamate decarboxylase activity
VCASEI_RS07515	COG1737	Transcriptional regulator
VCASEI_RS07520	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VCASEI_RS07525	COG3273	potassium ion transport
VCASEI_RS07525	COG2985	domain, Protein
VCASEI_RS07545	COG1960	acyl-CoA dehydrogenase activity
VCASEI_RS07555	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VCASEI_RS07570	COG4181	ATPase activity
VCASEI_RS07580	COG2814	Major facilitator Superfamily
VCASEI_RS07590	COG2067	long-chain fatty acid transport protein
VCASEI_RS07595	COG2067	long-chain fatty acid transport protein
VCASEI_RS07600	COG2267	carboxylic ester hydrolase activity
VCASEI_RS07605	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
VCASEI_RS07610	COG0583	DNA-binding transcription factor activity
VCASEI_RS07630	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
VCASEI_RS07635	COG1032	radical SAM domain protein
VCASEI_RS07650	COG0010	Belongs to the arginase family
VCASEI_RS07655	COG1166	arginine decarboxylase activity
VCASEI_RS07660	COG0668	transmembrane transport
VCASEI_RS07670	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
VCASEI_RS07675	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
VCASEI_RS07680	COG3454	Phosphonate metabolism
VCASEI_RS07685	COG4778	phosphonate C-P lyase system protein PhnL
VCASEI_RS07690	COG4107	phosphonate C-P lyase system protein PhnK
VCASEI_RS07695	COG3627	carbon phosphorus lyase activity
VCASEI_RS07700	COG3626	phosphonate metabolism
VCASEI_RS07705	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
VCASEI_RS07710	COG3624	Phosphonate C-P lyase system protein PhnG
VCASEI_RS07715	COG2188	Transcriptional regulator
VCASEI_RS07725	COG0826	peptidase U32
VCASEI_RS07735	COG3639	organic phosphonate transmembrane transporter activity
VCASEI_RS07755	COG2828	Protein conserved in bacteria
VCASEI_RS07760	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
VCASEI_RS07765	COG0372	Belongs to the citrate synthase family
VCASEI_RS07770	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
VCASEI_RS07805	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
VCASEI_RS07810	COG2885	chlorophyll binding
VCASEI_RS07815	COG0823	Involved in the tonB-independent uptake of proteins
VCASEI_RS07825	COG0848	biopolymer transport protein
VCASEI_RS07830	COG0811	peptide transport
VCASEI_RS07835	COG0824	Thioesterase
VCASEI_RS07845	COG4890	Cyd operon protein YbgT
VCASEI_RS07850	COG1294	oxidase, subunit
VCASEI_RS07855	COG1271	oxidase subunit
VCASEI_RS07860	COG2255	four-way junction helicase activity
VCASEI_RS07865	COG0632	four-way junction helicase activity
VCASEI_RS07870	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
VCASEI_RS07880	COG4106	trans-aconitate 2-methyltransferase activity
VCASEI_RS07885	COG0500	methyltransferase
VCASEI_RS07890	COG4067	protein conserved in archaea
VCASEI_RS07890	COG0189	ligase activity
VCASEI_RS07905	COG1435	thymidine kinase activity
VCASEI_RS07910	COG0215	cysteine-tRNA ligase activity
VCASEI_RS07915	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VCASEI_RS07920	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VCASEI_RS07925	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VCASEI_RS07930	COG3012	SEC-C Motif Domain Protein
VCASEI_RS07940	COG1566	PFAM secretion protein HlyD family protein
VCASEI_RS07950	COG0140	phosphoribosyl-ATP diphosphatase activity
VCASEI_RS07950	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
VCASEI_RS07965	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
VCASEI_RS07970	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VCASEI_RS07970	COG0131	Imidazoleglycerol-phosphate dehydratase
VCASEI_RS07975	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VCASEI_RS07980	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
VCASEI_RS07985	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
VCASEI_RS07990	COG1757	Na H antiporter
VCASEI_RS07995	COG2916	Histone family protein nucleoid-structuring protein H-NS
VCASEI_RS08000	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VCASEI_RS08005	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
VCASEI_RS08015	COG1199	ATP-dependent helicase activity
VCASEI_RS08020	COG0730	response to heat
VCASEI_RS08035	COG0501	Belongs to the peptidase M48B family
VCASEI_RS08040	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
VCASEI_RS08045	COG1073	alpha beta
VCASEI_RS08045	COG2226	methyltransferase
VCASEI_RS08050	COG0156	8-amino-7-oxononanoate synthase activity
VCASEI_RS08055	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
VCASEI_RS08070	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
VCASEI_RS08075	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
VCASEI_RS08080	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
VCASEI_RS08090	COG1522	sequence-specific DNA binding
VCASEI_RS08095	COG0686	Belongs to the AlaDH PNT family
VCASEI_RS08130	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VCASEI_RS08140	COG2116	formate transmembrane transporter activity
VCASEI_RS08145	COG0616	signal peptide processing
VCASEI_RS08150	COG1028	Short-chain dehydrogenase reductase Sdr
VCASEI_RS08155	COG1940	carbohydrate kinase activity
VCASEI_RS08160	COG0469	pyruvate kinase activity
VCASEI_RS08170	COG4667	esterase of the alpha-beta hydrolase superfamily
VCASEI_RS08175	COG0733	neurotransmitter:sodium symporter activity
VCASEI_RS08195	COG1263	PTS System
VCASEI_RS08195	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VCASEI_RS08195	COG2190	(PTS) system
VCASEI_RS08200	COG0084	hydrolase, TatD family'
VCASEI_RS08205	COG0470	DNA polymerase III
VCASEI_RS08210	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
VCASEI_RS08215	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
VCASEI_RS08245	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VCASEI_RS08260	COG1399	metal-binding, possibly nucleic acid-binding protein
VCASEI_RS08265	COG0424	maF-like protein
VCASEI_RS08270	COG0564	pseudouridine synthase activity
VCASEI_RS08275	COG1530	ribonuclease E activity
VCASEI_RS08280	COG0659	secondary active sulfate transmembrane transporter activity
VCASEI_RS08285	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
VCASEI_RS08290	COG2982	Protein involved in outer membrane biogenesis
VCASEI_RS08295	COG0717	Belongs to the dCTP deaminase family
VCASEI_RS08300	COG0572	uridine kinase
VCASEI_RS08305	COG0489	protein tyrosine kinase activity
VCASEI_RS08320	COG2186	Transcriptional regulator
VCASEI_RS08325	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VCASEI_RS08330	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
VCASEI_RS08335	COG0653	protein targeting
VCASEI_RS08340	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VCASEI_RS08345	COG3706	GGDEF domain
VCASEI_RS08350	COG1122	ATPase activity
VCASEI_RS08355	COG4120	Belongs to the binding-protein-dependent transport system permease family
VCASEI_RS08365	COG3092	negative regulation of chromosome organization
VCASEI_RS08370	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
VCASEI_RS08375	COG0280	phosphate acetyltransferase
VCASEI_RS08375	COG0857	belongs to the CobB CobQ family
VCASEI_RS08380	COG1742	UPF0060 membrane protein
VCASEI_RS08395	COG2855	membrane
VCASEI_RS08410	COG2267	carboxylic ester hydrolase activity
VCASEI_RS08415	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
VCASEI_RS08420	COG1169	isochorismate synthase
VCASEI_RS08425	COG0436	Aminotransferase
VCASEI_RS08430	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
VCASEI_RS08435	COG0232	Belongs to the dGTPase family. Type 2 subfamily
VCASEI_RS08455	COG1555	photosystem II stabilization
VCASEI_RS08460	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VCASEI_RS08465	COG0776	regulation of translation
VCASEI_RS08470	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
VCASEI_RS08475	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
VCASEI_RS08490	COG4191	Histidine kinase
VCASEI_RS08500	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VCASEI_RS08505	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VCASEI_RS08510	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VCASEI_RS08515	COG3842	ATPase activity
VCASEI_RS08520	COG0395	ABC-type sugar transport system, permease component
VCASEI_RS08525	COG1175	transmembrane transport
VCASEI_RS08530	COG1653	transport
VCASEI_RS08560	COG0814	amino acid
VCASEI_RS08570	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
VCASEI_RS08580	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
VCASEI_RS08585	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VCASEI_RS08590	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VCASEI_RS08595	COG2951	lytic endotransglycosylase activity
VCASEI_RS08600	COG3100	YcgL domain-containing protein
VCASEI_RS08610	COG2894	cell division
VCASEI_RS08615	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
VCASEI_RS08620	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
VCASEI_RS08625	COG0318	PFAM AMP-dependent synthetase and ligase
VCASEI_RS08630	COG0596	Alpha beta hydrolase
VCASEI_RS08635	COG3065	identical protein binding
VCASEI_RS08640	COG1214	PFAM Peptidase M22, glycoprotease
VCASEI_RS08645	COG1199	ATP-dependent helicase activity
VCASEI_RS08650	COG0788	formyltetrahydrofolate deformylase activity
VCASEI_RS08655	COG3102	Protein conserved in bacteria
VCASEI_RS08660	COG0018	arginyl-trna synthetase
VCASEI_RS08675	COG1918	ferrous iron import across plasma membrane
VCASEI_RS08685	COG0739	heme binding
VCASEI_RS08690	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
VCASEI_RS08695	COG1121	(ABC) transporter
VCASEI_RS08700	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VCASEI_RS08710	COG0366	Alpha amylase catalytic
VCASEI_RS08725	COG0508	dehydrogenase complex catalyzes the overall conversion of
VCASEI_RS08730	COG0567	Dehydrogenase, E1 component
VCASEI_RS08745	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
VCASEI_RS08760	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
VCASEI_RS08770	COG0033	Phosphoglucomutase
VCASEI_RS08775	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
VCASEI_RS08780	COG3258	Cytochrome c
VCASEI_RS08785	COG2863	cytochrome
VCASEI_RS08790	COG0596	Alpha beta hydrolase
VCASEI_RS08800	COG0716	FMN binding
VCASEI_RS08805	COG0735	belongs to the Fur family
VCASEI_RS08810	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VCASEI_RS08815	COG2190	(PTS) system
VCASEI_RS08815	COG1263	PTS System
VCASEI_RS08815	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VCASEI_RS08825	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
VCASEI_RS08830	COG1846	Transcriptional regulator
VCASEI_RS08830	COG1940	carbohydrate kinase activity
VCASEI_RS08840	COG0367	asparagine synthase
VCASEI_RS08855	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
VCASEI_RS08865	COG0326	Molecular chaperone. Has ATPase activity
VCASEI_RS08870	COG3710	Transcriptional regulator
VCASEI_RS08885	COG1090	epimerase
VCASEI_RS08890	COG3118	belongs to the thioredoxin family
VCASEI_RS08895	COG0789	Transcriptional regulator
VCASEI_RS08920	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
VCASEI_RS08930	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VCASEI_RS08940	COG2190	(PTS) system
VCASEI_RS08945	COG2837	iron assimilation
VCASEI_RS08965	COG1393	Belongs to the ArsC family
VCASEI_RS08985	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
VCASEI_RS08990	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VCASEI_RS08995	COG2716	regulation of RNA biosynthetic process
VCASEI_RS09000	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
VCASEI_RS09015	COG4783	chaperone-mediated protein folding
VCASEI_RS09020	COG1393	Belongs to the ArsC family
VCASEI_RS09035	COG0583	DNA-binding transcription factor activity
VCASEI_RS09040	COG2130	NADP-dependent
VCASEI_RS09045	COG1979	alcohol dehydrogenase
VCASEI_RS09065	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
VCASEI_RS09070	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
VCASEI_RS09075	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
VCASEI_RS09080	COG0121	glutamine amidotransferase
VCASEI_RS09085	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VCASEI_RS09090	COG1960	acyl-CoA dehydrogenase activity
VCASEI_RS09100	COG0328	RNA-DNA hybrid ribonuclease activity
VCASEI_RS09105	COG2226	methyltransferase
VCASEI_RS09110	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VCASEI_RS09115	COG0741	lytic transglycosylase activity
VCASEI_RS09115	COG1388	LysM domain
VCASEI_RS09120	COG3021	interspecies interaction between organisms
VCASEI_RS09125	COG0347	Belongs to the P(II) protein family
VCASEI_RS09135	COG0825	malonyl-CoA metabolic process
VCASEI_RS09140	COG0587	DNA-directed DNA polymerase activity
VCASEI_RS09145	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
VCASEI_RS09160	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VCASEI_RS09165	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VCASEI_RS09170	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
VCASEI_RS09180	COG0750	zinc metalloprotease
VCASEI_RS09190	COG0575	Belongs to the CDS family
VCASEI_RS09195	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
VCASEI_RS09210	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
VCASEI_RS09220	COG0024	Methionine aminopeptidase
VCASEI_RS09225	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
VCASEI_RS09235	COG0564	pseudouridine synthase activity
VCASEI_RS09240	COG3098	single-species biofilm formation
VCASEI_RS09260	COG1671	Belongs to the UPF0178 family
VCASEI_RS09265	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
VCASEI_RS09275	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VCASEI_RS09275	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VCASEI_RS09285	COG1611	Belongs to the LOG family
VCASEI_RS09295	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
VCASEI_RS09300	COG2363	Small membrane protein
VCASEI_RS09310	COG0583	DNA-binding transcription factor activity
VCASEI_RS09315	COG0301	tRNA thio-modification
VCASEI_RS09315	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VCASEI_RS09325	COG0142	geranyltranstransferase activity
VCASEI_RS09330	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
VCASEI_RS09340	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
VCASEI_RS09350	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VCASEI_RS09370	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VCASEI_RS09370	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VCASEI_RS09375	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
VCASEI_RS09390	COG0456	acetyltransferase
VCASEI_RS09400	COG3153	acetyltransferase
VCASEI_RS09405	COG3154	lipid carrier protein
VCASEI_RS09410	COG0826	peptidase U32
VCASEI_RS09415	COG0826	peptidase U32
VCASEI_RS09440	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
VCASEI_RS09445	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
VCASEI_RS09450	COG0195	Participates in both transcription termination and antitermination
VCASEI_RS09455	COG0779	Required for maturation of 30S ribosomal subunits
VCASEI_RS09470	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VCASEI_RS09475	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VCASEI_RS09480	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
VCASEI_RS09485	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VCASEI_RS09495	COG1534	Rna-binding protein
VCASEI_RS09500	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VCASEI_RS09505	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VCASEI_RS09510	COG2027	D-alanyl-D-alanine carboxypeptidase
VCASEI_RS09515	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
VCASEI_RS09520	COG0505	Belongs to the CarA family
VCASEI_RS09525	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
VCASEI_RS09530	COG0335	large ribosomal subunit rRNA binding
VCASEI_RS09535	COG0336	Belongs to the RNA methyltransferase TrmD family
VCASEI_RS09540	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
VCASEI_RS09555	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VCASEI_RS09560	COG2188	Transcriptional regulator
VCASEI_RS09570	COG1228	amidohydrolase
VCASEI_RS09575	COG0010	Belongs to the arginase family
VCASEI_RS09580	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
VCASEI_RS09585	COG2986	histidine ammonia-lyase
VCASEI_RS09590	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
VCASEI_RS09595	COG4137	Cytochrome C assembly protein
VCASEI_RS09600	COG4536	flavin adenine dinucleotide binding
VCASEI_RS09605	COG1854	S-ribosylhomocysteine lyase activity
VCASEI_RS09615	COG2918	glutathione biosynthetic process
VCASEI_RS09620	COG0612	Peptidase, M16
VCASEI_RS09625	COG1238	metal cluster binding
VCASEI_RS09640	COG1063	alcohol dehydrogenase
VCASEI_RS09685	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
VCASEI_RS09690	COG2137	regulation of response to DNA damage stimulus
VCASEI_RS09695	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
VCASEI_RS09700	COG1546	Belongs to the CinA family
VCASEI_RS09705	COG2358	TRAP transporter, solute receptor (TAXI family
VCASEI_RS09715	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
VCASEI_RS09720	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VCASEI_RS09725	COG1388	LysM domain
VCASEI_RS09725	COG4942	peptidase
VCASEI_RS09745	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
VCASEI_RS09750	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
VCASEI_RS09755	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
VCASEI_RS09760	COG0148	phosphopyruvate hydratase activity
VCASEI_RS09770	COG3956	TIGRFAM MazG family protein
VCASEI_RS09775	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VCASEI_RS09785	COG2205	protein histidine kinase activity
VCASEI_RS09785	COG4999	Histidine kinase
VCASEI_RS09785	COG3850	Histidine kinase
VCASEI_RS09785	COG3437	response regulator, receiver
VCASEI_RS09795	COG0736	holo-[acyl-carrier-protein] synthase activity
VCASEI_RS09800	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
VCASEI_RS09805	COG1381	Involved in DNA repair and RecF pathway recombination
VCASEI_RS09810	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
VCASEI_RS09825	COG0481	GTPase activity
VCASEI_RS09830	COG3086	response to oxidative stress
VCASEI_RS09840	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
VCASEI_RS09845	COG1595	DNA-templated transcription, initiation
VCASEI_RS09850	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
VCASEI_RS09860	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
VCASEI_RS09865	COG0583	DNA-binding transcription factor activity
VCASEI_RS09875	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
VCASEI_RS09880	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VCASEI_RS09885	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VCASEI_RS09890	COG1116	anion transmembrane transporter activity
VCASEI_RS09930	COG3604	Transcriptional regulator
VCASEI_RS10005	COG0366	Alpha amylase catalytic
VCASEI_RS10010	COG2190	(PTS) system
VCASEI_RS10010	COG1263	PTS System
VCASEI_RS10010	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VCASEI_RS10020	COG0582	viral genome integration into host DNA
VCASEI_RS10025	COG0519	Catalyzes the synthesis of GMP from XMP
VCASEI_RS10025	COG0518	GMP synthase (glutamine-hydrolyzing) activity
VCASEI_RS10030	COG0517	IMP dehydrogenase activity
VCASEI_RS10030	COG0516	GMP reductase activity
VCASEI_RS10035	COG1570	exodeoxyribonuclease VII activity
VCASEI_RS10045	COG1160	GTP binding
VCASEI_RS10050	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VCASEI_RS10055	COG2976	Protein conserved in bacteria
VCASEI_RS10060	COG0124	histidyl-tRNA synthetase
VCASEI_RS10085	COG0105	UTP biosynthetic process
VCASEI_RS10090	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VCASEI_RS10095	COG2975	iron-sulfur cluster assembly
VCASEI_RS10100	COG0633	Ferredoxin
VCASEI_RS10120	COG0822	iron-sulfur transferase activity
VCASEI_RS10125	COG1104	cysteine desulfurase activity
VCASEI_RS10130	COG1959	2 iron, 2 sulfur cluster binding
VCASEI_RS10140	COG0483	inositol monophosphate 1-phosphatase activity
VCASEI_RS10145	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VCASEI_RS10150	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VCASEI_RS10155	COG1862	Preprotein translocase
VCASEI_RS10160	COG0343	queuine tRNA-ribosyltransferase activity
VCASEI_RS10165	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
VCASEI_RS10170	COG0583	DNA-binding transcription factor activity
VCASEI_RS10175	COG0450	alkyl hydroperoxide reductase
VCASEI_RS10180	COG3142	Participates in the control of copper homeostasis
VCASEI_RS10185	COG0704	Plays a role in the regulation of phosphate uptake
VCASEI_RS10190	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VCASEI_RS10195	COG0573	inorganic phosphate transmembrane transporter activity
VCASEI_RS10200	COG0573	inorganic phosphate transmembrane transporter activity
VCASEI_RS10205	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
VCASEI_RS10210	COG0248	Ppx GppA phosphatase
VCASEI_RS10220	COG5002	protein histidine kinase activity
VCASEI_RS10225	COG0745	RESPONSE REGULATOR receiver
VCASEI_RS10230	COG2974	May be involved in recombination
VCASEI_RS10235	COG0826	peptidase U32
VCASEI_RS10240	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VCASEI_RS10290	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VCASEI_RS10295	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
VCASEI_RS10300	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VCASEI_RS10310	COG0590	tRNA wobble adenosine to inosine editing
VCASEI_RS10320	COG0542	response to heat
VCASEI_RS10330	COG0564	pseudouridine synthase activity
VCASEI_RS10335	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VCASEI_RS10340	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VCASEI_RS10345	COG0077	Prephenate dehydratase
VCASEI_RS10345	COG1605	Chorismate mutase
VCASEI_RS10350	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
VCASEI_RS10355	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
VCASEI_RS10365	COG0488	(ABC) transporter
VCASEI_RS10370	COG0739	heme binding
VCASEI_RS10370	COG1196	nuclear chromosome segregation
VCASEI_RS10370	COG0741	lytic transglycosylase activity
VCASEI_RS10375	COG1605	Chorismate mutase
VCASEI_RS10375	COG0287	Prephenate dehydrogenase
VCASEI_RS10385	COG3275	phosphorelay sensor kinase activity
VCASEI_RS10390	COG3279	Response regulator of the LytR AlgR family
VCASEI_RS10400	COG0189	ligase activity
VCASEI_RS10400	COG0569	domain protein
VCASEI_RS10420	COG1966	Carbon starvation protein
VCASEI_RS10425	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
VCASEI_RS10430	COG1047	Peptidyl-prolyl cis-trans
VCASEI_RS10435	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
VCASEI_RS10440	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
VCASEI_RS10445	COG0196	riboflavin kinase activity
VCASEI_RS10450	COG0728	peptidoglycan biosynthetic process
VCASEI_RS10455	COG0268	Binds directly to 16S ribosomal RNA
VCASEI_RS10460	COG0640	Transcriptional regulator
VCASEI_RS10465	COG0583	DNA-binding transcription factor activity
VCASEI_RS10545	COG3436	PFAM IS66 Orf2 family protein
VCASEI_RS10555	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VCASEI_RS10560	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VCASEI_RS10565	COG4107	phosphonate C-P lyase system protein PhnK
VCASEI_RS10570	COG3627	carbon phosphorus lyase activity
VCASEI_RS10575	COG3626	phosphonate metabolism
VCASEI_RS10595	COG1120	ATPase activity
VCASEI_RS10600	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VCASEI_RS10605	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VCASEI_RS10610	COG0583	DNA-binding transcription factor activity
VCASEI_RS10620	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
VCASEI_RS10660	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
VCASEI_RS10670	COG0494	nUDIX hydrolase
VCASEI_RS10685	COG0667	Aldo Keto reductase
VCASEI_RS10695	COG2204	response regulator
VCASEI_RS10700	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
VCASEI_RS10710	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
VCASEI_RS10725	COG4974	Belongs to the 'phage' integrase family
VCASEI_RS10740	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
VCASEI_RS10745	COG0513	Belongs to the DEAD box helicase family
VCASEI_RS10750	COG3022	response to hydroperoxide
VCASEI_RS10755	COG1115	amino acid carrier protein
VCASEI_RS10770	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
VCASEI_RS10775	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
VCASEI_RS10780	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
VCASEI_RS10785	COG0083	homoserine kinase activity
VCASEI_RS10795	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VCASEI_RS10800	COG0745	RESPONSE REGULATOR receiver
VCASEI_RS10805	COG2198	Histidine kinase
VCASEI_RS10805	COG0784	Response regulator, receiver
VCASEI_RS10805	COG5002	protein histidine kinase activity
VCASEI_RS10810	COG5001	Diguanylate cyclase
VCASEI_RS10810	COG4251	negative regulation of phosphorylation
VCASEI_RS10810	COG3706	GGDEF domain
VCASEI_RS10810	COG2203	Gaf domain
VCASEI_RS10820	COG0069	glutamate synthase activity
VCASEI_RS10820	COG0070	glutamate synthase
VCASEI_RS10820	COG0067	glutamate synthase
VCASEI_RS10840	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VCASEI_RS10845	COG2860	membrane
VCASEI_RS10850	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VCASEI_RS10855	COG0739	heme binding
VCASEI_RS10860	COG0316	Belongs to the HesB IscA family
VCASEI_RS10870	COG0628	permease
VCASEI_RS10875	COG2813	Specifically methylates the guanine in position
VCASEI_RS10885	COG0747	negative chemotaxis
VCASEI_RS10895	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VCASEI_RS10900	COG0444	Belongs to the ABC transporter superfamily
VCASEI_RS10905	COG4608	Belongs to the ABC transporter superfamily
VCASEI_RS10915	COG2971	BadF BadG BcrA BcrD
VCASEI_RS10935	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VCASEI_RS10940	COG2814	Major facilitator Superfamily
VCASEI_RS10960	COG1840	ABC-type Fe3 transport system, periplasmic component
VCASEI_RS10965	COG0004	ammonium transporteR
VCASEI_RS10970	COG0347	Belongs to the P(II) protein family
VCASEI_RS10975	COG3112	Uncharacterised protein family (UPF0231)
VCASEI_RS10980	COG1049	propionate catabolic process, 2-methylcitrate cycle
VCASEI_RS10985	COG1752	Esterase of the alpha-beta hydrolase superfamily
VCASEI_RS10990	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VCASEI_RS10995	COG1643	Atp-dependent helicase
VCASEI_RS11000	COG1489	DNA binding
VCASEI_RS11005	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
VCASEI_RS11010	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VCASEI_RS11020	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VCASEI_RS11025	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
VCASEI_RS11035	COG0842	Transport permease protein
VCASEI_RS11040	COG1131	(ABC) transporter
VCASEI_RS11045	COG0288	reversible hydration of carbon dioxide
VCASEI_RS11060	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VCASEI_RS11065	COG0508	dehydrogenase complex catalyzes the overall conversion of
VCASEI_RS11070	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
VCASEI_RS11075	COG2186	Transcriptional regulator
VCASEI_RS11085	COG0157	Belongs to the NadC ModD family
VCASEI_RS11095	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VCASEI_RS11100	COG1459	type II secretion system
VCASEI_RS11110	COG0237	dephospho-CoA kinase activity
VCASEI_RS11115	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
VCASEI_RS11125	COG0494	nUDIX hydrolase
VCASEI_RS11130	COG0653	protein targeting
VCASEI_RS11140	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
VCASEI_RS11145	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
VCASEI_RS11150	COG0849	cell division
VCASEI_RS11155	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
VCASEI_RS11160	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VCASEI_RS11165	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
VCASEI_RS11170	COG0772	Belongs to the SEDS family
VCASEI_RS11180	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VCASEI_RS11185	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
VCASEI_RS11195	COG0768	penicillin binding
VCASEI_RS11200	COG3116	cell division
VCASEI_RS11220	COG2706	6-phosphogluconolactonase activity
VCASEI_RS11225	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
VCASEI_RS11230	COG3107	peptidoglycan biosynthetic process
VCASEI_RS11235	COG0792	nuclease activity
VCASEI_RS11240	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VCASEI_RS11245	COG2823	Periplasmic or secreted lipoprotein
VCASEI_RS11250	COG1522	sequence-specific DNA binding
VCASEI_RS11255	COG2962	Rard protein
VCASEI_RS11265	COG1349	DNA-binding transcription factor activity
VCASEI_RS11275	COG0440	acetolactate synthase activity
VCASEI_RS11280	COG0028	Belongs to the TPP enzyme family
VCASEI_RS11305	COG0473	3-isopropylmalate dehydrogenase activity
VCASEI_RS11315	COG0066	3-isopropylmalate dehydratase activity
VCASEI_RS11325	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
VCASEI_RS11330	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
VCASEI_RS11335	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VCASEI_RS11340	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
VCASEI_RS11355	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
VCASEI_RS11365	COG3610	response to peptide
VCASEI_RS11370	COG2966	Psort location CytoplasmicMembrane, score
VCASEI_RS11375	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
VCASEI_RS11380	COG0211	Belongs to the bacterial ribosomal protein bL27 family
VCASEI_RS11390	COG0142	geranyltranstransferase activity
VCASEI_RS11395	COG0039	L-malate dehydrogenase activity
VCASEI_RS11400	COG1438	arginine binding
VCASEI_RS11410	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VCASEI_RS11420	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
VCASEI_RS11425	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
VCASEI_RS11435	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
VCASEI_RS11440	COG1178	ABC-type Fe3 transport system permease component
VCASEI_RS11450	COG0163	prenyltransferase activity
VCASEI_RS11455	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VCASEI_RS11460	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
VCASEI_RS11465	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
VCASEI_RS11475	COG2911	Protein conserved in bacteria
VCASEI_RS11480	COG0729	surface antigen
VCASEI_RS11495	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
VCASEI_RS11505	COG1136	(ABC) transporter
VCASEI_RS11510	COG4591	ABC-type transport system involved in lipoprotein release permease component
VCASEI_RS11520	COG0529	Catalyzes the synthesis of activated sulfate
VCASEI_RS11525	COG3273	potassium ion transport
VCASEI_RS11525	COG0471	metal ion transport
VCASEI_RS11530	COG2895	sulfate adenylyltransferase (ATP) activity
VCASEI_RS11535	COG0175	sulfate reduction
VCASEI_RS11540	COG1648	precorrin-2 dehydrogenase activity
VCASEI_RS11540	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VCASEI_RS11545	COG2153	protein acetylation
VCASEI_RS11550	COG3266	domain, Protein
VCASEI_RS11550	COG3061	Opacity-associated protein A
VCASEI_RS11555	COG0545	Peptidyl-prolyl cis-trans isomerase
VCASEI_RS11565	COG0203	ribosomal protein L17
VCASEI_RS11570	COG0202	RNA polymerase activity
VCASEI_RS11585	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
VCASEI_RS11590	COG0257	Belongs to the bacterial ribosomal protein bL36 family
VCASEI_RS11595	COG0201	protein transport
VCASEI_RS11600	COG0200	Binds to the 23S rRNA
VCASEI_RS11605	COG1841	ribosomal large subunit assembly
VCASEI_RS11620	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
VCASEI_RS11625	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
VCASEI_RS11630	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
VCASEI_RS11635	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
VCASEI_RS11640	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
VCASEI_RS11660	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
VCASEI_RS11665	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
VCASEI_RS11670	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
VCASEI_RS11675	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
VCASEI_RS11680	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
VCASEI_RS11685	COG0089	rRNA binding
VCASEI_RS11690	COG0088	Forms part of the polypeptide exit tunnel
VCASEI_RS11695	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
VCASEI_RS11705	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VCASEI_RS11710	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VCASEI_RS11725	COG2168	tRNA wobble position uridine thiolation
VCASEI_RS11730	COG2923	Belongs to the DsrF TusC family
VCASEI_RS11735	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
VCASEI_RS11740	COG2964	Protein conserved in bacteria
VCASEI_RS11745	COG0545	Peptidyl-prolyl cis-trans isomerase
VCASEI_RS11750	COG2900	Belongs to the SlyX family
VCASEI_RS11755	COG1047	Peptidyl-prolyl cis-trans
VCASEI_RS11760	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
VCASEI_RS11770	COG2249	NAD(P)H dehydrogenase (quinone) activity
VCASEI_RS11775	COG0488	(ABC) transporter
VCASEI_RS11790	COG3954	Phosphoribulokinase
VCASEI_RS11795	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VCASEI_RS11800	COG0814	amino acid
VCASEI_RS11805	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
VCASEI_RS11810	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
VCASEI_RS11815	COG1561	YicC-like family, N-terminal region
VCASEI_RS11825	COG1061	Type III restriction enzyme res subunit
VCASEI_RS11840	COG4232	protein-disulfide reductase activity
VCASEI_RS11845	COG3118	belongs to the thioredoxin family
VCASEI_RS11860	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
VCASEI_RS11865	COG2169	Transcriptional regulator
VCASEI_RS11870	COG0243	molybdopterin cofactor binding
VCASEI_RS11875	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
VCASEI_RS11880	COG0194	GDP metabolic process
VCASEI_RS11890	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VCASEI_RS11905	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
VCASEI_RS11910	COG0512	Glutamine amidotransferase of anthranilate synthase
VCASEI_RS11915	COG0180	Tryptophanyl-tRNA synthetase
VCASEI_RS11920	COG0546	phosphoglycolate phosphatase activity
VCASEI_RS11925	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
VCASEI_RS11930	COG0338	D12 class N6 adenine-specific DNA methyltransferase
VCASEI_RS11940	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
VCASEI_RS11945	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
VCASEI_RS11975	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
VCASEI_RS11990	COG1566	PFAM secretion protein HlyD family protein
VCASEI_RS12000	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VCASEI_RS12000	COG0165	Argininosuccinate lyase
VCASEI_RS12005	COG0137	argininosuccinate synthase activity
VCASEI_RS12015	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
VCASEI_RS12020	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VCASEI_RS12025	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
VCASEI_RS12035	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
VCASEI_RS12040	COG0460	homoserine dehydrogenase
VCASEI_RS12040	COG0527	aspartate kinase activity
VCASEI_RS12045	COG0626	cystathionine gamma-synthase activity
VCASEI_RS12050	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
VCASEI_RS12055	COG0281	malic enzyme
VCASEI_RS12060	COG0254	rRNA binding
VCASEI_RS12065	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
VCASEI_RS12070	COG1609	Transcriptional regulator
VCASEI_RS12080	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
VCASEI_RS12090	COG1575	Belongs to the MenA family. Type 1 subfamily
VCASEI_RS12100	COG3074	FtsZ-dependent cytokinesis
VCASEI_RS12105	COG1494	fructose-1,6-bisphosphatase
VCASEI_RS12135	COG0205	6-phosphofructokinase activity
VCASEI_RS12140	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
VCASEI_RS12145	COG0210	DNA helicase
VCASEI_RS12165	COG0471	metal ion transport
VCASEI_RS12170	COG0783	Belongs to the Dps family
VCASEI_RS12175	COG2081	HI0933 family
VCASEI_RS12185	COG1528	Iron-storage protein
VCASEI_RS12190	COG0589	response to stress
VCASEI_RS12205	COG4067	protein conserved in archaea
VCASEI_RS12205	COG0189	ligase activity
VCASEI_RS12215	COG5001	Diguanylate cyclase
VCASEI_RS12215	COG5002	protein histidine kinase activity
VCASEI_RS12220	COG1522	sequence-specific DNA binding
VCASEI_RS12250	COG0583	DNA-binding transcription factor activity
VCASEI_RS12265	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
VCASEI_RS12270	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VCASEI_RS12290	COG0673	inositol 2-dehydrogenase activity
VCASEI_RS12295	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VCASEI_RS12300	COG0601	transmembrane transport
VCASEI_RS12350	COG1309	transcriptional regulator
VCASEI_RS12355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VCASEI_RS12360	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VCASEI_RS12365	COG2960	long-chain fatty acid transporting porin activity
VCASEI_RS12370	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
VCASEI_RS12375	COG0583	DNA-binding transcription factor activity
VCASEI_RS12425	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
VCASEI_RS12440	COG3118	belongs to the thioredoxin family
VCASEI_RS12445	COG0513	Belongs to the DEAD box helicase family
VCASEI_RS12450	COG0248	Ppx GppA phosphatase
VCASEI_RS12465	COG0084	hydrolase, TatD family'
VCASEI_RS12470	COG0805	protein transport
VCASEI_RS12475	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VCASEI_RS12480	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VCASEI_RS12495	COG2226	methyltransferase
VCASEI_RS12500	COG1322	Protein conserved in bacteria
VCASEI_RS12505	COG0697	spore germination
VCASEI_RS12525	COG2022	thiamine diphosphate biosynthetic process
VCASEI_RS12530	COG2104	thiamine diphosphate biosynthetic process
VCASEI_RS12535	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VCASEI_RS12540	COG0352	thiamine-phosphate diphosphorylase activity
VCASEI_RS12545	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
VCASEI_RS12550	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
VCASEI_RS12585	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VCASEI_RS12590	COG1739	Uncharacterized protein family UPF0029
VCASEI_RS12595	COG1250	3-hydroxyacyl-CoA dehydrogenase
VCASEI_RS12595	COG1024	Enoyl-CoA hydratase
VCASEI_RS12600	COG0183	Belongs to the thiolase family
VCASEI_RS12605	COG3072	Adenylate cyclase
VCASEI_RS12615	COG1587	Uroporphyrinogen-III synthase
VCASEI_RS12620	COG2959	enzyme of heme biosynthesis
VCASEI_RS12625	COG3071	HemY protein
VCASEI_RS12655	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
VCASEI_RS12665	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
VCASEI_RS12670	COG0408	coproporphyrinogen oxidase activity
VCASEI_RS12675	COG0009	L-threonylcarbamoyladenylate synthase
VCASEI_RS12680	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
VCASEI_RS12685	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
VCASEI_RS12690	COG0551	DNA topoisomerase type I activity
VCASEI_RS12695	COG2922	Belongs to the Smg family
VCASEI_RS12700	COG0758	DNA mediated transformation
VCASEI_RS12715	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
VCASEI_RS12720	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VCASEI_RS12720	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VCASEI_RS12725	COG0569	domain protein
VCASEI_RS12730	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VCASEI_RS12735	COG1272	protein, Hemolysin III
VCASEI_RS12745	COG3084	Protein conserved in bacteria
VCASEI_RS12755	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
VCASEI_RS12760	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VCASEI_RS12765	COG0606	chelatase, subunit chli
VCASEI_RS12775	COG3978	acetolactate synthase activity
VCASEI_RS12800	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
VCASEI_RS12805	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VCASEI_RS12805	COG1263	PTS System
VCASEI_RS12810	COG0583	DNA-binding transcription factor activity
VCASEI_RS12815	COG2814	Major facilitator Superfamily
VCASEI_RS12825	COG0355	proton-transporting ATP synthase activity, rotational mechanism
VCASEI_RS12830	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
VCASEI_RS12835	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
VCASEI_RS12845	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
VCASEI_RS12850	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
VCASEI_RS12860	COG0356	it plays a direct role in the translocation of protons across the membrane
VCASEI_RS12870	COG1475	DNA binding
VCASEI_RS12875	COG1192	Involved in chromosome partitioning
VCASEI_RS12880	COG0357	Ribosomal RNA small subunit methyltransferase G
VCASEI_RS12885	COG0445	tRNA wobble uridine modification
VCASEI_RS12915	COG2084	Dehydrogenase
VCASEI_RS12920	COG2979	Protein of unknown function (DUF533)
VCASEI_RS12930	COG0534	Mate efflux family protein
VCASEI_RS12935	COG2207	Transcriptional regulator
VCASEI_RS12960	COG0786	glutamate:sodium symporter activity
VCASEI_RS12965	COG1434	Gram-negative-bacterium-type cell wall biogenesis
VCASEI_RS12970	COG4948	Mandelate Racemase Muconate Lactonizing
VCASEI_RS12980	COG1064	alcohol dehydrogenase
VCASEI_RS12985	COG2207	Transcriptional regulator
VCASEI_RS13020	COG1987	bacterial-type flagellum assembly
VCASEI_RS13030	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
VCASEI_RS13040	COG1815	bacterial-type flagellum-dependent cell motility
VCASEI_RS13045	COG1558	bacterial-type flagellum-dependent cell motility
VCASEI_RS13055	COG1749	Flagellar hook protein flgE
VCASEI_RS13065	COG4786	Flagellar basal body rod
VCASEI_RS13070	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
VCASEI_RS13075	COG1706	bacterial-type flagellum-dependent cell motility
VCASEI_RS13090	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VCASEI_RS13100	COG1677	Flagellar hook-basal body complex protein FliE
VCASEI_RS13165	COG3436	PFAM IS66 Orf2 family protein
VCASEI_RS13180	COG1280	lysine exporter protein (LysE YggA)
VCASEI_RS13195	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VCASEI_RS13200	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
VCASEI_RS13230	COG1191	sigma factor activity
VCASEI_RS13235	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
VCASEI_RS13240	COG1360	Flagellar Motor Protein
VCASEI_RS13255	COG2916	Histone family protein nucleoid-structuring protein H-NS
VCASEI_RS13265	COG0625	glutathione transferase activity
VCASEI_RS13290	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
VCASEI_RS13295	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
VCASEI_RS13295	COG1565	acr, cog1565
VCASEI_RS13300	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
VCASEI_RS13320	COG3346	SURF1 family
VCASEI_RS13330	COG1612	heme a metabolic process
VCASEI_RS13335	COG0109	protoheme IX farnesyltransferase activity
VCASEI_RS13345	COG0583	DNA-binding transcription factor activity
VCASEI_RS13355	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VCASEI_RS13365	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VCASEI_RS13370	COG4232	protein-disulfide reductase activity
VCASEI_RS13385	COG1522	sequence-specific DNA binding
VCASEI_RS13390	COG2814	Major facilitator Superfamily
VCASEI_RS13395	COG0583	DNA-binding transcription factor activity
VCASEI_RS13400	COG0583	DNA-binding transcription factor activity
VCASEI_RS13420	COG1129	ABC transporter
VCASEI_RS13425	COG1172	Belongs to the binding-protein-dependent transport system permease family
VCASEI_RS13435	COG0667	Aldo Keto reductase
VCASEI_RS13440	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
VCASEI_RS13450	COG1070	Carbohydrate kinase
VCASEI_RS13455	COG1454	alcohol dehydrogenase
VCASEI_RS13475	COG1309	transcriptional regulator
VCASEI_RS13485	COG2801	Transposase and inactivated derivatives
VCASEI_RS13495	COG0519	Catalyzes the synthesis of GMP from XMP
VCASEI_RS13500	COG1414	Transcriptional regulator
VCASEI_RS13505	COG1414	Transcriptional regulator
VCASEI_RS13515	COG1011	Hydrolase
VCASEI_RS13525	COG0697	spore germination
VCASEI_RS13560	COG4176	ABC-type proline glycine betaine transport system permease component
VCASEI_RS13565	COG4175	Glycine betaine
VCASEI_RS13570	COG0251	oxidation-reduction process
VCASEI_RS13580	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VCASEI_RS13590	COG0418	dihydroorotase activity
VCASEI_RS13595	COG0633	Ferredoxin
VCASEI_RS13595	COG3217	Mosc domain protein beta barrel domain protein
VCASEI_RS13600	COG0561	phosphatase activity
VCASEI_RS13605	COG0697	spore germination
VCASEI_RS13610	COG0583	DNA-binding transcription factor activity
VCASEI_RS13620	COG3119	arylsulfatase activity
VCASEI_RS13630	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
VCASEI_RS13635	COG0513	Belongs to the DEAD box helicase family
VCASEI_RS13645	COG0583	DNA-binding transcription factor activity
VCASEI_RS13650	COG3384	dioxygenase
VCASEI_RS13655	COG2259	Doxx family
VCASEI_RS13660	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VCASEI_RS13670	COG0384	phenazine biosynthesis protein PhzF
VCASEI_RS13675	COG1230	cation diffusion facilitator family transporter
VCASEI_RS13690	COG3842	ATPase activity
VCASEI_RS13700	COG1177	transmembrane transport
VCASEI_RS13725	COG0583	DNA-binding transcription factor activity
VCASEI_RS13750	COG0583	DNA-binding transcription factor activity
VCASEI_RS13755	COG0730	response to heat
VCASEI_RS13770	COG0583	DNA-binding transcription factor activity
VCASEI_RS13790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VCASEI_RS13795	COG3722	fumarate hydratase activity
VCASEI_RS13805	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
VCASEI_RS13805	COG2213	PTS system mannitol-specific
VCASEI_RS13810	COG1741	Belongs to the pirin family
VCASEI_RS13825	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VCASEI_RS13830	COG4977	sequence-specific DNA binding
VCASEI_RS13855	COG2197	response regulator
VCASEI_RS13865	COG1129	ABC transporter
VCASEI_RS13870	COG1172	Belongs to the binding-protein-dependent transport system permease family
VCASEI_RS13895	COG3069	C4-dicarboxylate transmembrane transporter activity
VCASEI_RS13900	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
VCASEI_RS13910	COG1737	Transcriptional regulator
VCASEI_RS13920	COG1067	ATP-dependent peptidase activity
VCASEI_RS13930	COG2885	chlorophyll binding
VCASEI_RS13945	COG0243	molybdopterin cofactor binding
VCASEI_RS13950	COG0437	4 iron, 4 sulfur cluster binding
VCASEI_RS13955	COG3302	dmso reductase anchor subunit
VCASEI_RS13980	COG4667	esterase of the alpha-beta hydrolase superfamily
VCASEI_RS13990	COG1757	Na H antiporter
VCASEI_RS14000	COG2354	Protein conserved in bacteria
VCASEI_RS14025	COG4681	YaeQ
VCASEI_RS14030	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
VCASEI_RS14045	COG0789	Transcriptional regulator
VCASEI_RS14050	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
VCASEI_RS14075	COG5413	integral membrane protein
VCASEI_RS14090	COG0737	Belongs to the 5'-nucleotidase family
VCASEI_RS14095	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VCASEI_RS14100	COG1085	galactose-1-phosphate uridylyltransferase
VCASEI_RS14105	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
VCASEI_RS14110	COG3547	Transposase (IS116 IS110 IS902 family)
VCASEI_RS14130	COG3436	PFAM IS66 Orf2 family protein
VCASEI_RS14170	COG3436	PFAM IS66 Orf2 family protein
VCASEI_RS14200	COG1396	sequence-specific DNA binding
VCASEI_RS14225	COG2273	Hydrolase Family 16
VCASEI_RS14240	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VCASEI_RS14245	COG0583	DNA-binding transcription factor activity
VCASEI_RS14260	COG0583	DNA-binding transcription factor activity
VCASEI_RS14265	COG2070	2-Nitropropane dioxygenase
VCASEI_RS14270	COG1064	alcohol dehydrogenase
VCASEI_RS14280	COG4651	solute:proton antiporter activity
VCASEI_RS14280	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VCASEI_RS14300	COG0668	transmembrane transport
VCASEI_RS14315	COG1742	UPF0060 membrane protein
VCASEI_RS14330	COG1263	PTS System
VCASEI_RS14330	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VCASEI_RS14335	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VCASEI_RS14340	COG1621	beta-fructofuranosidase activity
VCASEI_RS14345	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
VCASEI_RS14345	COG0574	Belongs to the PEP-utilizing enzyme family
VCASEI_RS14350	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
VCASEI_RS14365	COG0583	DNA-binding transcription factor activity
VCASEI_RS14370	COG3135	benzoate transporter
VCASEI_RS14380	COG1309	transcriptional regulator
VCASEI_RS14390	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VCASEI_RS14395	COG3622	Belongs to the hyi family
VCASEI_RS14400	COG0235	Class ii aldolase
VCASEI_RS14405	COG3395	kinase activity
VCASEI_RS14410	COG2084	Dehydrogenase
VCASEI_RS14415	COG1349	DNA-binding transcription factor activity
VCASEI_RS14420	COG1280	lysine exporter protein (LysE YggA)
VCASEI_RS14440	COG4264	IucA IucC family
VCASEI_RS14455	COG1120	ATPase activity
VCASEI_RS14460	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VCASEI_RS14465	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VCASEI_RS14475	COG0006	proline dipeptidase activity
VCASEI_RS14480	COG1522	sequence-specific DNA binding
VCASEI_RS14485	COG1012	belongs to the aldehyde dehydrogenase family
VCASEI_RS14490	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
VCASEI_RS14505	COG4206	TonB-dependent receptor
VCASEI_RS14540	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
VCASEI_RS14565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VCASEI_RS14575	COG0747	negative chemotaxis
VCASEI_RS14605	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
VCASEI_RS14615	COG1984	allophanate hydrolase subunit 2
VCASEI_RS14625	COG3706	GGDEF domain
VCASEI_RS14635	COG4993	Dehydrogenase
VCASEI_RS14680	COG3138	arginine N-succinyltransferase
VCASEI_RS14685	COG1012	belongs to the aldehyde dehydrogenase family
VCASEI_RS14690	COG3724	N-succinylarginine dihydrolase activity
VCASEI_RS14705	COG1054	Belongs to the UPF0176 family
VCASEI_RS14710	COG0205	6-phosphofructokinase activity
VCASEI_RS14745	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VCASEI_RS14755	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
VCASEI_RS14775	COG4807	Protein conserved in bacteria
VCASEI_RS14785	COG0516	GMP reductase activity
VCASEI_RS14785	COG0517	IMP dehydrogenase activity
VCASEI_RS14790	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VCASEI_RS14810	COG0110	maltose O-acetyltransferase activity
VCASEI_RS14835	COG1131	(ABC) transporter
VCASEI_RS14840	COG0842	Transport permease protein
VCASEI_RS14855	COG1289	transmembrane transporter activity
VCASEI_RS14860	COG0210	DNA helicase
VCASEI_RS14880	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VCASEI_RS14885	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VCASEI_RS14890	COG1151	hydroxylamine reductase activity
VCASEI_RS14895	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VCASEI_RS14900	COG0653	protein targeting
VCASEI_RS14905	COG2181	nitrate reductase activity
VCASEI_RS14910	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
VCASEI_RS14915	COG1140	nitrate reductase beta subunit
VCASEI_RS14920	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
VCASEI_RS14925	COG2223	nitrite transmembrane transporter activity
VCASEI_RS14930	COG3850	Histidine kinase
VCASEI_RS14935	COG2197	response regulator
VCASEI_RS14940	COG1172	Belongs to the binding-protein-dependent transport system permease family
VCASEI_RS14945	COG1172	Belongs to the binding-protein-dependent transport system permease family
VCASEI_RS14950	COG1129	ABC transporter
VCASEI_RS14955	COG1879	ABC-type sugar transport system periplasmic component
VCASEI_RS14960	COG1803	Methylglyoxal synthase
VCASEI_RS14980	COG0516	GMP reductase activity
VCASEI_RS15045	COG3436	PFAM IS66 Orf2 family protein
VCASEI_RS15060	COG0582	viral genome integration into host DNA
VCASEI_RS15075	COG1609	Transcriptional regulator
VCASEI_RS15080	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VCASEI_RS15085	COG1879	ABC-type sugar transport system periplasmic component
VCASEI_RS15090	COG1172	Belongs to the binding-protein-dependent transport system permease family
VCASEI_RS15095	COG1129	ABC transporter
VCASEI_RS15100	COG1869	D-ribose catabolic process
VCASEI_RS15105	COG0123	including yeast histone deacetylase and acetoin utilization protein
VCASEI_RS15115	COG1451	nucleotide metabolic process
VCASEI_RS15125	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VCASEI_RS15135	COG4181	ATPase activity
VCASEI_RS15140	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
VCASEI_RS15250	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
VCASEI_RS15270	COG1328	CTP reductase activity
VCASEI_RS15275	COG0602	queuosine metabolic process
VCASEI_RS15285	COG0189	ligase activity
VCASEI_RS15285	COG4067	protein conserved in archaea
VCASEI_RS15290	COG0346	lactoylglutathione lyase activity
VCASEI_RS15295	COG1492	cobalamin metabolic process
VCASEI_RS15300	COG2005	Transcriptional regulator
VCASEI_RS15300	COG3585	molybdate ion transport
VCASEI_RS15305	COG0725	ABC transporter, periplasmic molybdate-binding protein
VCASEI_RS15310	COG4149	molybdate abc transporter
VCASEI_RS15315	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
VCASEI_RS15320	COG3769	mannosylglycerate metabolic process
VCASEI_RS15325	COG1215	transferase activity, transferring glycosyl groups
VCASEI_RS15335	COG0521	Mo-molybdopterin cofactor biosynthetic process
VCASEI_RS15360	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
VCASEI_RS15370	COG0515	serine threonine protein kinase
VCASEI_RS15370	COG2815	serine threonine protein kinase
VCASEI_RS15380	COG1794	racemase activity, acting on amino acids and derivatives
VCASEI_RS15415	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
VCASEI_RS15420	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
VCASEI_RS15430	COG0745	RESPONSE REGULATOR receiver
VCASEI_RS15440	COG3140	Belongs to the UPF0181 family
VCASEI_RS15500	COG0534	Mate efflux family protein
VCASEI_RS15505	COG0023	Translation Initiation Factor
VCASEI_RS15515	COG1181	Belongs to the D-alanine--D-alanine ligase family
VCASEI_RS15525	COG0045	succinate-CoA ligase (ADP-forming) activity
VCASEI_RS15525	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VCASEI_RS15525	COG1042	CoA-binding domain protein
VCASEI_RS15535	COG1629	transport
VCASEI_RS15535	COG4771	TonB-dependent receptor
VCASEI_RS15540	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VCASEI_RS15565	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VCASEI_RS15570	COG3118	belongs to the thioredoxin family
VCASEI_RS15580	COG0602	queuosine metabolic process
VCASEI_RS15585	COG0720	synthase
VCASEI_RS15605	COG4533	DNA binding
VCASEI_RS15615	COG2050	protein possibly involved in aromatic compounds catabolism
VCASEI_RS15750	COG0748	coenzyme F420 binding
VCASEI_RS15755	COG3721	Heme iron utilization protein
VCASEI_RS15760	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
VCASEI_RS15765	COG0811	peptide transport
VCASEI_RS15770	COG0848	biopolymer transport protein
VCASEI_RS15775	COG4558	Periplasmic binding protein
VCASEI_RS15780	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VCASEI_RS15795	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
VCASEI_RS15800	COG0513	Belongs to the DEAD box helicase family
VCASEI_RS15805	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
VCASEI_RS15815	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
VCASEI_RS15840	COG2824	Alkylphosphonate utilization operon protein PhnA
VCASEI_RS15855	COG0179	Fumarylacetoacetate (FAA) hydrolase
VCASEI_RS15860	COG0419	ATPase involved in DNA repair
VCASEI_RS15865	COG0420	3'-5' exonuclease activity
VCASEI_RS15875	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VCASEI_RS15905	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
VCASEI_RS15910	COG1309	transcriptional regulator
VCASEI_RS15915	COG0513	Belongs to the DEAD box helicase family
VCASEI_RS15930	COG3436	PFAM IS66 Orf2 family protein
VCASEI_RS15950	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
VCASEI_RS15955	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VCASEI_RS15985	COG4145	pantothenate transmembrane transporter activity
VCASEI_RS15995	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
VCASEI_RS16000	COG1737	Transcriptional regulator
VCASEI_RS16040	COG0714	Associated with various cellular activities
VCASEI_RS16055	COG1278	Cold shock
VCASEI_RS16080	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VCASEI_RS16085	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
VCASEI_RS16110	COG3436	PFAM IS66 Orf2 family protein
VCASEI_RS16125	COG0523	cobalamin synthesis protein
VCASEI_RS16145	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
VCASEI_RS16150	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
VCASEI_RS16155	COG2353	YceI-like domain
VCASEI_RS16160	COG3038	cytochrome b561
VCASEI_RS16165	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
VCASEI_RS16180	COG5001	Diguanylate cyclase
VCASEI_RS16185	COG1063	alcohol dehydrogenase
VCASEI_RS16200	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
VCASEI_RS16230	COG2188	Transcriptional regulator
VCASEI_RS16240	COG1765	OsmC-like protein
VCASEI_RS16245	COG3304	Inner membrane component domain
VCASEI_RS16255	COG0668	transmembrane transport
VCASEI_RS16260	COG0546	phosphoglycolate phosphatase activity
VCASEI_RS16295	COG0545	Peptidyl-prolyl cis-trans isomerase
VCASEI_RS16300	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VCASEI_RS16310	COG0302	gtp cyclohydrolase
VCASEI_RS16315	COG0303	'Molybdopterin
VCASEI_RS16320	COG0861	Integral membrane protein TerC family
VCASEI_RS16325	COG0737	Belongs to the 5'-nucleotidase family
VCASEI_RS16330	COG3593	DNA synthesis involved in DNA repair
VCASEI_RS16335	COG0561	phosphatase activity
VCASEI_RS16345	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VCASEI_RS16345	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VCASEI_RS16345	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VCASEI_RS16355	COG2207	Transcriptional regulator
VCASEI_RS16360	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VCASEI_RS16360	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VCASEI_RS16360	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VCASEI_RS16370	COG0488	(ABC) transporter
VCASEI_RS16375	COG0513	Belongs to the DEAD box helicase family
VCASEI_RS16385	COG0004	ammonium transporteR
VCASEI_RS16390	COG1940	carbohydrate kinase activity
VCASEI_RS16410	COG2897	thiosulfate sulfurtransferase activity
VCASEI_RS16445	COG2814	Major facilitator Superfamily
VCASEI_RS16455	COG4989	oxidoreductase activity
VCASEI_RS16470	COG1312	Catalyzes the dehydration of D-mannonate
VCASEI_RS16475	COG0246	Mannitol dehydrogenase
VCASEI_RS16480	COG0246	Mannitol dehydrogenase
VCASEI_RS16485	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VCASEI_RS16495	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VCASEI_RS16510	COG2721	sulfolactate sulfo-lyase activity
VCASEI_RS16520	COG3530	Putative quorum-sensing-regulated virulence factor
VCASEI_RS16530	COG0714	Associated with various cellular activities
VCASEI_RS16550	COG2304	oxidoreductase activity
VCASEI_RS16565	COG0671	phosphoesterase, PA-phosphatase related
VCASEI_RS16570	COG2814	Major facilitator Superfamily
VCASEI_RS16585	COG2146	nitrite reductase [NAD(P)H] activity
VCASEI_RS16585	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VCASEI_RS16590	COG1116	anion transmembrane transporter activity
VCASEI_RS16595	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VCASEI_RS16600	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VCASEI_RS16610	COG1648	precorrin-2 dehydrogenase activity
VCASEI_RS16610	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VCASEI_RS16615	COG0243	molybdopterin cofactor binding
VCASEI_RS16630	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
VCASEI_RS16640	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VCASEI_RS16655	COG0235	Class ii aldolase
VCASEI_RS16660	COG3254	rhamnose metabolic process
VCASEI_RS16675	COG2176	DNA-directed DNA polymerase activity
VCASEI_RS16690	COG1028	Short-chain dehydrogenase reductase Sdr
VCASEI_RS16695	COG1917	Cupin 2, conserved barrel domain protein
VCASEI_RS16705	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VCASEI_RS16710	COG0800	Aldolase
VCASEI_RS16720	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VCASEI_RS16725	COG0823	Involved in the tonB-independent uptake of proteins
VCASEI_RS16730	COG0534	Mate efflux family protein
VCASEI_RS16740	COG4677	pectinesterase activity
VCASEI_RS16745	COG1653	transport
VCASEI_RS16750	COG3842	ATPase activity
VCASEI_RS16755	COG0395	ABC-type sugar transport system, permease component
VCASEI_RS16760	COG1175	transmembrane transport
VCASEI_RS16775	COG4677	pectinesterase activity
VCASEI_RS16780	COG0402	S-adenosylhomocysteine deaminase activity
VCASEI_RS16785	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
VCASEI_RS16785	COG3608	succinylglutamate desuccinylase aspartoacylase
VCASEI_RS16790	COG1529	Aldehyde oxidase and xanthine dehydrogenase
VCASEI_RS16800	COG0814	amino acid
VCASEI_RS16805	COG1309	transcriptional regulator
VCASEI_RS16810	COG2084	Dehydrogenase
VCASEI_RS16815	COG3622	Belongs to the hyi family
VCASEI_RS16820	COG3960	tartronate-semialdehyde synthase activity
VCASEI_RS16825	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
VCASEI_RS16835	COG2186	Transcriptional regulator
VCASEI_RS16845	COG3111	PFAM Bacterial OB fold (BOF) protein
VCASEI_RS16850	COG2770	Histidine kinase
VCASEI_RS16850	COG2205	protein histidine kinase activity
VCASEI_RS16860	COG0628	permease
VCASEI_RS16865	COG0110	maltose O-acetyltransferase activity
VCASEI_RS16875	COG0243	molybdopterin cofactor binding
VCASEI_RS16880	COG3005	denitrification pathway
VCASEI_RS16890	COG1247	-acetyltransferase
VCASEI_RS16895	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
VCASEI_RS16920	COG1051	belongs to the nudix hydrolase family
VCASEI_RS16950	COG2351	hydroxyisourate hydrolase activity
VCASEI_RS16955	COG2252	PERMEase
VCASEI_RS16960	COG1609	Transcriptional regulator
VCASEI_RS16965	COG3152	Membrane
VCASEI_RS16970	COG1538	Outer membrane efflux protein
VCASEI_RS16975	COG0577	efflux transmembrane transporter activity
VCASEI_RS16975	COG1136	(ABC) transporter
VCASEI_RS16980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VCASEI_RS17000	COG2207	Transcriptional regulator
VCASEI_RS17000	COG1609	Transcriptional regulator
VCASEI_RS17005	COG1070	Carbohydrate kinase
VCASEI_RS17015	COG0477	Major facilitator Superfamily
VCASEI_RS17015	COG2814	Major facilitator Superfamily
VCASEI_RS17020	COG2115	Belongs to the xylose isomerase family
VCASEI_RS17035	COG1175	transmembrane transport
VCASEI_RS17040	COG0395	ABC-type sugar transport system, permease component
VCASEI_RS17045	COG3842	ATPase activity
VCASEI_RS17050	COG2211	Major facilitator Superfamily
VCASEI_RS17055	COG3940	Belongs to the glycosyl hydrolase 43 family
VCASEI_RS17060	COG2017	converts alpha-aldose to the beta-anomer
VCASEI_RS17065	COG0110	maltose O-acetyltransferase activity
VCASEI_RS17070	COG1280	lysine exporter protein (LysE YggA)
VCASEI_RS17090	COG0561	phosphatase activity
VCASEI_RS17105	COG2160	L-arabinose isomerase activity
VCASEI_RS17115	COG1069	ribulokinase activity
VCASEI_RS17120	COG1879	ABC-type sugar transport system periplasmic component
VCASEI_RS17125	COG1129	ABC transporter
VCASEI_RS17130	COG1172	Belongs to the binding-protein-dependent transport system permease family
VCASEI_RS17135	COG1757	Na H antiporter
VCASEI_RS17175	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VCASEI_RS17180	COG0697	spore germination
VCASEI_RS17220	COG1640	4-alpha-glucanotransferase
VCASEI_RS17235	COG0405	Gamma-glutamyltransferase
VCASEI_RS17255	COG3833	ABC-type maltose transport systems, permease component
VCASEI_RS17260	COG1175	transmembrane transport
VCASEI_RS17265	COG2182	Extracellular solute-binding protein
VCASEI_RS17270	COG3842	ATPase activity
VCASEI_RS17280	COG0737	Belongs to the 5'-nucleotidase family
VCASEI_RS17290	COG4580	involved in the transport of maltose and maltodextrins
VCASEI_RS17295	COG0366	Alpha amylase catalytic
VCASEI_RS17320	COG4565	transcriptional regulatory protein
VCASEI_RS17325	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
VCASEI_RS17335	COG0523	cobalamin synthesis protein
VCASEI_RS17345	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
VCASEI_RS17350	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VCASEI_RS17355	COG4067	protein conserved in archaea
VCASEI_RS17355	COG0189	ligase activity
VCASEI_RS17360	COG0189	ligase activity
VCASEI_RS17370	COG1335	isochorismatase
VCASEI_RS17375	COG3123	guanosine phosphorylase activity
VCASEI_RS17390	COG0531	amino acid
VCASEI_RS17445	COG0527	aspartate kinase activity
VCASEI_RS17450	COG0662	Cupin 2, conserved barrel domain protein
VCASEI_RS17455	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
VCASEI_RS17460	COG0456	acetyltransferase
VCASEI_RS17490	COG0513	Belongs to the DEAD box helicase family
VCASEI_RS17495	COG3314	Sporulation integral membrane protein YlbJ
VCASEI_RS17510	COG0625	glutathione transferase activity
VCASEI_RS17540	COG0830	nickel cation binding
VCASEI_RS17550	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
VCASEI_RS17555	COG0804	urea catabolic process
VCASEI_RS17560	COG0832	Belongs to the urease beta subunit family
VCASEI_RS17565	COG0831	urea catabolic process
VCASEI_RS17570	COG0829	nickel cation binding
VCASEI_RS17585	COG0300	oxidoreductase activity
VCASEI_RS17605	COG1278	Cold shock
VCASEI_RS17610	COG0668	transmembrane transport
VCASEI_RS17630	COG4214	carbohydrate transport
VCASEI_RS17655	COG0765	amino acid transport
VCASEI_RS17660	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
VCASEI_RS17665	COG1609	Transcriptional regulator
VCASEI_RS17700	COG2771	luxR family
VCASEI_RS17700	COG2200	EAL domain
VCASEI_RS17705	COG0583	DNA-binding transcription factor activity
VCASEI_RS17710	COG3257	ureidoglycine aminohydrolase activity
VCASEI_RS17715	COG5002	protein histidine kinase activity
VCASEI_RS17725	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
VCASEI_RS17730	COG2194	sulfuric ester hydrolase activity
VCASEI_RS17750	COG0573	inorganic phosphate transmembrane transporter activity
VCASEI_RS17760	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VCASEI_RS17765	COG1414	Transcriptional regulator
VCASEI_RS17770	COG0280	phosphate acetyltransferase
VCASEI_RS17775	COG0730	response to heat
VCASEI_RS17785	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VCASEI_RS17785	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VCASEI_RS17790	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VCASEI_RS17795	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VCASEI_RS17830	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
VCASEI_RS17835	COG0573	inorganic phosphate transmembrane transporter activity
VCASEI_RS17840	COG0581	inorganic phosphate transmembrane transporter activity
VCASEI_RS17845	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VCASEI_RS17850	COG0583	DNA-binding transcription factor activity
VCASEI_RS17855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VCASEI_RS17860	COG4597	amino acid ABC transporter
VCASEI_RS17865	COG0765	amino acid transport
VCASEI_RS17870	COG1126	abc transporter atp-binding protein
VCASEI_RS17875	COG1446	asparaginase
VCASEI_RS17880	COG2199	diguanylate cyclase activity
VCASEI_RS17890	COG0307	riboflavin synthase, alpha
VCASEI_RS17895	COG2197	response regulator
VCASEI_RS17900	COG3850	Histidine kinase
VCASEI_RS17915	COG0243	molybdopterin cofactor binding
VCASEI_RS17925	COG3005	denitrification pathway
VCASEI_RS17945	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VCASEI_RS17955	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
VCASEI_RS17965	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VCASEI_RS17970	COG2146	nitrite reductase [NAD(P)H] activity
VCASEI_RS17975	COG2116	formate transmembrane transporter activity
VCASEI_RS17980	COG1648	precorrin-2 dehydrogenase activity
VCASEI_RS17980	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VCASEI_RS17995	COG2827	Endonuclease containing a URI domain
VCASEI_RS18000	COG3132	Protein of unknown function, DUF480
VCASEI_RS18010	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
VCASEI_RS18015	COG0513	Belongs to the DEAD box helicase family
VCASEI_RS18020	COG1609	Transcriptional regulator
VCASEI_RS18025	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
VCASEI_RS18025	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VCASEI_RS18030	COG1105	Belongs to the carbohydrate kinase PfkB family
VCASEI_RS18035	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VCASEI_RS18035	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
VCASEI_RS18035	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VCASEI_RS18050	COG1917	Cupin 2, conserved barrel domain protein
VCASEI_RS18050	COG2207	Transcriptional regulator
VCASEI_RS18055	COG0564	pseudouridine synthase activity
VCASEI_RS18060	COG0110	maltose O-acetyltransferase activity
VCASEI_RS18070	COG1115	amino acid carrier protein
VCASEI_RS18080	COG0509	glycine decarboxylation via glycine cleavage system
VCASEI_RS18085	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
VCASEI_RS18085	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
VCASEI_RS18175	COG1464	Belongs to the NlpA lipoprotein family
VCASEI_RS18200	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
VCASEI_RS18205	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VCASEI_RS18210	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VCASEI_RS18215	COG1764	response to oxidative stress
VCASEI_RS18220	COG1846	Transcriptional regulator
VCASEI_RS18230	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VCASEI_RS18235	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VCASEI_RS18240	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VCASEI_RS18265	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VCASEI_RS18270	COG4605	iron ion homeostasis
VCASEI_RS18275	COG4604	ABC transporter, ATP-binding protein
VCASEI_RS18280	COG0583	DNA-binding transcription factor activity
VCASEI_RS18285	COG4771	TonB-dependent receptor
VCASEI_RS18305	COG2814	Major facilitator Superfamily
VCASEI_RS18325	COG1012	belongs to the aldehyde dehydrogenase family
VCASEI_RS18345	COG4175	Glycine betaine
VCASEI_RS18360	COG0697	spore germination
VCASEI_RS18365	COG1803	Methylglyoxal synthase
VCASEI_RS18365	COG1597	lipid kinase activity
VCASEI_RS18375	COG3842	ATPase activity
VCASEI_RS18380	COG1176	ABC-type spermidine putrescine transport system, permease component I
VCASEI_RS18385	COG1177	transmembrane transport
VCASEI_RS18395	COG1280	lysine exporter protein (LysE YggA)
VCASEI_RS18405	COG2207	Transcriptional regulator
VCASEI_RS18420	COG1278	Cold shock
VCASEI_RS18425	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VCASEI_RS18445	COG0259	pyridoxamine-phosphate oxidase activity
VCASEI_RS18450	COG1444	tRNA N-acetyltransferase activity
VCASEI_RS18465	COG1609	Transcriptional regulator
VCASEI_RS18470	COG3250	beta-galactosidase activity
VCASEI_RS18480	COG2211	Major facilitator Superfamily
VCASEI_RS18495	COG0675	Transposase, IS605 OrfB family
VCASEI_RS18505	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VCASEI_RS18510	COG1085	galactose-1-phosphate uridylyltransferase
VCASEI_RS18515	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
VCASEI_RS18520	COG2017	converts alpha-aldose to the beta-anomer
VCASEI_RS18525	COG2271	Major facilitator Superfamily
VCASEI_RS18530	COG3851	Histidine kinase
VCASEI_RS18535	COG2197	response regulator
VCASEI_RS18565	COG2376	Dihydroxyacetone kinase
VCASEI_RS18570	COG1461	Dihydroxyacetone kinase
VCASEI_RS18590	COG1401	restriction endodeoxyribonuclease activity
VCASEI_RS18605	COG3436	PFAM IS66 Orf2 family protein
VCASEI_RS18630	COG1397	ADP-ribosylglycohydrolase
VCASEI_RS18645	COG3344	reverse transcriptase
VCASEI_RS18655	COG3436	PFAM IS66 Orf2 family protein
VCASEI_RS18700	COG1349	DNA-binding transcription factor activity
VCASEI_RS18710	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VCASEI_RS18715	COG0738	Major facilitator superfamily
VCASEI_RS18885	COG3436	PFAM IS66 Orf2 family protein
VCASEI_RS18900	COG1609	Transcriptional regulator
VCASEI_RS18905	COG2723	6-phospho-beta-galactosidase activity
VCASEI_RS18915	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VCASEI_RS18915	COG1263	PTS System
VCASEI_RS18915	COG2190	(PTS) system
VCASEI_RS18940	COG0583	DNA-binding transcription factor activity
VCASEI_RS18945	COG1380	Effector of murein hydrolase LrgA
VCASEI_RS18950	COG1346	cytolysis
VCASEI_RS18980	COG2026	Addiction module toxin, RelE StbE family
VCASEI_RS19000	COG3866	Pectate lyase
VCASEI_RS19010	COG1620	l-lactate permease
VCASEI_RS19020	COG0583	DNA-binding transcription factor activity
VCASEI_RS19025	COG2433	Pfam Transposase IS66
VCASEI_RS19085	COG3436	PFAM IS66 Orf2 family protein
VCASEI_RS19115	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
VCASEI_RS19130	COG3177	Filamentation induced by cAMP protein fic
VCASEI_RS19180	COG5564	TIM-barrel signal transduction protein
VCASEI_RS19185	COG5441	Belongs to the UPF0261 family
VCASEI_RS19225	COG1192	Involved in chromosome partitioning
VCASEI_RS19265	COG1304	FMN binding
VCASEI_RS19305	COG0675	Transposase, IS605 OrfB family
VCASEI_RS19315	COG3077	Addiction module antitoxin, RelB DinJ family
VCASEI_RS19320	COG2026	Addiction module toxin, RelE StbE family