locus-tag	class	description
EPB12_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EPB12_RS00010	COG0592	DNA-directed DNA polymerase activity
EPB12_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EPB12_RS00025	COG0071	Belongs to the small heat shock protein (HSP20) family
EPB12_RS00030	COG3977	Valine--pyruvate aminotransferase
EPB12_RS00035	COG0366	Alpha amylase catalytic
EPB12_RS00040	COG0751	glycine-tRNA ligase activity
EPB12_RS00045	COG0752	glycyl-tRNA synthetase alpha subunit
EPB12_RS00050	COG2119	membrane
EPB12_RS00060	COG0425	Belongs to the sulfur carrier protein TusA family
EPB12_RS00075	COG0604	alcohol dehydrogenase
EPB12_RS00080	COG0183	Belongs to the thiolase family
EPB12_RS00085	COG1250	3-hydroxyacyl-CoA dehydrogenase
EPB12_RS00085	COG1024	Enoyl-CoA hydratase
EPB12_RS00090	COG1739	Uncharacterized protein family UPF0029
EPB12_RS00100	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
EPB12_RS00150	COG2132	Multicopper oxidase
EPB12_RS00160	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
EPB12_RS00165	COG0352	thiamine-phosphate diphosphorylase activity
EPB12_RS00170	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EPB12_RS00175	COG2104	thiamine diphosphate biosynthetic process
EPB12_RS00180	COG2022	thiamine diphosphate biosynthetic process
EPB12_RS00185	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EPB12_RS00190	COG0006	proline dipeptidase activity
EPB12_RS00190	COG0006	proline dipeptidase activity
EPB12_RS00220	COG3220	belongs to the UPF0276 family
EPB12_RS00230	COG0210	DNA helicase
EPB12_RS00245	COG0405	Gamma-glutamyltransferase
EPB12_RS00250	COG1280	lysine exporter protein (LysE YggA)
EPB12_RS00260	COG2962	Rard protein
EPB12_RS00265	COG0514	ATP-dependent DNA helicase (RecQ)
EPB12_RS00275	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
EPB12_RS00285	COG0861	Integral membrane protein TerC family
EPB12_RS00295	COG0248	Ppx GppA phosphatase
EPB12_RS00300	COG0513	Belongs to the DEAD box helicase family
EPB12_RS00305	COG3118	belongs to the thioredoxin family
EPB12_RS00320	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
EPB12_RS00325	COG2871	sodium ion transport
EPB12_RS00385	COG2959	enzyme of heme biosynthesis
EPB12_RS00390	COG1587	Uroporphyrinogen-III synthase
EPB12_RS00395	COG0181	hydroxymethylbilane synthase activity
EPB12_RS00405	COG1965	Belongs to the frataxin family
EPB12_RS00415	COG0019	diaminopimelate decarboxylase activity
EPB12_RS00420	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EPB12_RS00430	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
EPB12_RS00435	COG1011	Hydrolase
EPB12_RS00440	COG2200	EAL domain
EPB12_RS00440	COG2199	diguanylate cyclase activity
EPB12_RS00440	COG3287	FIST C domain
EPB12_RS00445	COG2199	diguanylate cyclase activity
EPB12_RS00445	COG2200	EAL domain
EPB12_RS00445	COG3287	FIST C domain
EPB12_RS00450	COG3148	PFAM DTW domain containing protein
EPB12_RS00465	COG0561	phosphatase activity
EPB12_RS00470	COG2267	carboxylic ester hydrolase activity
EPB12_RS00475	COG1280	lysine exporter protein (LysE YggA)
EPB12_RS00480	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
EPB12_RS00485	COG0640	Transcriptional regulator
EPB12_RS00490	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EPB12_RS00535	COG2095	MarC family integral membrane protein
EPB12_RS00545	COG0742	ribosomal rna small subunit methyltransferase
EPB12_RS00550	COG0552	protein localization to endoplasmic reticulum
EPB12_RS00555	COG2884	Cell division ATP-binding protein ftsE
EPB12_RS00560	COG2177	Part of the ABC transporter FtsEX involved in
EPB12_RS00575	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EPB12_RS00585	COG1580	Controls the rotational direction of flagella during chemotaxis
EPB12_RS00610	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EPB12_RS00620	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EPB12_RS00625	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
EPB12_RS00635	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EPB12_RS00655	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EPB12_RS00730	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EPB12_RS00735	COG4206	TonB-dependent receptor
EPB12_RS00745	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EPB12_RS00835	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EPB12_RS00845	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EPB12_RS00855	COG1072	(Pantothenic acid kinase))
EPB12_RS00880	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EPB12_RS00885	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EPB12_RS00890	COG0250	Participates in transcription elongation, termination and antitermination
EPB12_RS00900	COG0081	regulation of translation
EPB12_RS00905	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EPB12_RS00925	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
EPB12_RS00930	COG2816	NAD+ diphosphatase activity
EPB12_RS00940	COG1573	uracil-dna glycosylase
EPB12_RS00950	COG3068	Protein conserved in bacteria
EPB12_RS00955	COG1253	flavin adenine dinucleotide binding
EPB12_RS00970	COG0151	Belongs to the GarS family
EPB12_RS00975	COG0138	bifunctional purine biosynthesis protein purh
EPB12_RS00980	COG0789	Transcriptional regulator
EPB12_RS00985	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
EPB12_RS00990	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EPB12_RS00995	COG2264	protein methyltransferase activity
EPB12_RS01000	COG0439	Biotin carboxylase
EPB12_RS01005	COG0511	ligase activity, forming carbon-carbon bonds
EPB12_RS01010	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EPB12_RS01015	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EPB12_RS01030	COG2814	Major facilitator Superfamily
EPB12_RS01035	COG2205	protein histidine kinase activity
EPB12_RS01035	COG0784	Response regulator, receiver
EPB12_RS01035	COG2198	Histidine kinase
EPB12_RS01050	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EPB12_RS01060	COG3263	regulation of cellular component size
EPB12_RS01070	COG4232	protein-disulfide reductase activity
EPB12_RS01075	COG1438	arginine binding
EPB12_RS01080	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
EPB12_RS01085	COG0540	Belongs to the ATCase OTCase family
EPB12_RS01090	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EPB12_RS01095	COG0549	Belongs to the carbamate kinase family
EPB12_RS01105	COG1288	antiporter activity
EPB12_RS01110	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EPB12_RS01115	COG1027	Aspartate ammonia-lyase
EPB12_RS01120	COG3030	protein affecting phage T7 exclusion by the F plasmid
EPB12_RS01125	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EPB12_RS01135	COG2205	protein histidine kinase activity
EPB12_RS01140	COG0745	RESPONSE REGULATOR receiver
EPB12_RS01145	COG3678	ATP-independent chaperone mediated protein folding
EPB12_RS01150	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EPB12_RS01155	COG0205	6-phosphofructokinase activity
EPB12_RS01160	COG2852	Protein conserved in bacteria
EPB12_RS01165	COG0149	triose-phosphate isomerase activity
EPB12_RS01175	COG3152	Membrane
EPB12_RS01190	COG1494	fructose-1,6-bisphosphatase
EPB12_RS01195	COG3074	FtsZ-dependent cytokinesis
EPB12_RS01200	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EPB12_RS01205	COG1575	Belongs to the MenA family. Type 1 subfamily
EPB12_RS01210	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
EPB12_RS01215	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EPB12_RS01225	COG1609	Transcriptional regulator
EPB12_RS01240	COG0254	rRNA binding
EPB12_RS01250	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
EPB12_RS01280	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EPB12_RS01285	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EPB12_RS01300	COG0165	Argininosuccinate lyase
EPB12_RS01300	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
EPB12_RS01310	COG0251	oxidation-reduction process
EPB12_RS01315	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EPB12_RS01320	COG0678	peroxiredoxin activity
EPB12_RS01320	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EPB12_RS01330	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EPB12_RS01365	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EPB12_RS01375	COG0338	D12 class N6 adenine-specific DNA methyltransferase
EPB12_RS01380	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EPB12_RS01385	COG0546	phosphoglycolate phosphatase activity
EPB12_RS01390	COG0180	Tryptophanyl-tRNA synthetase
EPB12_RS01400	COG0512	Glutamine amidotransferase of anthranilate synthase
EPB12_RS01405	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EPB12_RS01415	COG1012	belongs to the aldehyde dehydrogenase family
EPB12_RS01425	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EPB12_RS01430	COG3954	Phosphoribulokinase
EPB12_RS01435	COG3089	Belongs to the UPF0270 family
EPB12_RS01440	COG0429	hydrolase of the alpha beta-hydrolase fold
EPB12_RS01450	COG0488	(ABC) transporter
EPB12_RS01455	COG2249	NAD(P)H dehydrogenase (quinone) activity
EPB12_RS01470	COG1047	Peptidyl-prolyl cis-trans
EPB12_RS01475	COG1446	asparaginase
EPB12_RS01480	COG2900	Belongs to the SlyX family
EPB12_RS01490	COG0545	Peptidyl-prolyl cis-trans isomerase
EPB12_RS01495	COG2964	Protein conserved in bacteria
EPB12_RS01500	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
EPB12_RS01505	COG2923	Belongs to the DsrF TusC family
EPB12_RS01525	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EPB12_RS01530	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EPB12_RS01535	COG2906	2 iron, 2 sulfur cluster binding
EPB12_RS01550	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EPB12_RS01555	COG0088	Forms part of the polypeptide exit tunnel
EPB12_RS01560	COG0089	rRNA binding
EPB12_RS01565	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EPB12_RS01570	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EPB12_RS01585	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EPB12_RS01595	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EPB12_RS01610	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EPB12_RS01615	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EPB12_RS01620	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EPB12_RS01625	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EPB12_RS01630	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
EPB12_RS01635	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EPB12_RS01640	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
EPB12_RS01645	COG1841	ribosomal large subunit assembly
EPB12_RS01650	COG0200	Binds to the 23S rRNA
EPB12_RS01655	COG0201	protein transport
EPB12_RS01660	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EPB12_RS01665	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EPB12_RS01670	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EPB12_RS01675	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EPB12_RS01680	COG0202	RNA polymerase activity
EPB12_RS01685	COG0203	ribosomal protein L17
EPB12_RS01695	COG0545	Peptidyl-prolyl cis-trans isomerase
EPB12_RS01700	COG3061	Opacity-associated protein A
EPB12_RS01700	COG3266	domain, Protein
EPB12_RS01710	COG2153	protein acetylation
EPB12_RS01745	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EPB12_RS01745	COG0189	ligase activity
EPB12_RS01755	COG0737	Belongs to the 5'-nucleotidase family
EPB12_RS01765	COG0175	sulfate reduction
EPB12_RS01770	COG2895	sulfate adenylyltransferase (ATP) activity
EPB12_RS01775	COG3273	potassium ion transport
EPB12_RS01775	COG0471	metal ion transport
EPB12_RS01780	COG0529	Catalyzes the synthesis of activated sulfate
EPB12_RS01815	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
EPB12_RS01825	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EPB12_RS01830	COG0729	surface antigen
EPB12_RS01835	COG2911	Protein conserved in bacteria
EPB12_RS01840	COG2105	PFAM AIG2 family protein
EPB12_RS01845	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
EPB12_RS01850	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EPB12_RS01855	COG0163	prenyltransferase activity
EPB12_RS01865	COG1178	ABC-type Fe3 transport system permease component
EPB12_RS01870	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
EPB12_RS01875	COG3028	Belongs to the UPF0307 family
EPB12_RS01880	COG0312	modulator of DNA gyrase
EPB12_RS01885	COG2239	Acts as a magnesium transporter
EPB12_RS01890	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EPB12_RS01895	COG1660	Displays ATPase and GTPase activities
EPB12_RS01900	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EPB12_RS01905	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EPB12_RS01915	COG1137	ATPase activity
EPB12_RS01920	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
EPB12_RS01930	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
EPB12_RS01935	COG0517	IMP dehydrogenase activity
EPB12_RS01935	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
EPB12_RS01945	COG1127	ABC transporter
EPB12_RS01950	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EPB12_RS01955	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EPB12_RS01960	COG2854	intermembrane phospholipid transfer
EPB12_RS01970	COG5007	Belongs to the BolA IbaG family
EPB12_RS01975	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EPB12_RS01980	COG0204	Acyl-transferase
EPB12_RS01985	COG0251	oxidation-reduction process
EPB12_RS01990	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
EPB12_RS02030	COG0525	valine-tRNA ligase activity
EPB12_RS02035	COG2927	DNA polymerase III (CHI subunit)
EPB12_RS02040	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EPB12_RS02045	COG0795	lipopolysaccharide-transporting ATPase activity
EPB12_RS02050	COG0795	lipopolysaccharide-transporting ATPase activity
EPB12_RS02205	COG0741	lytic transglycosylase activity
EPB12_RS02210	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
EPB12_RS02225	COG2066	Belongs to the glutaminase family
EPB12_RS02235	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EPB12_RS02240	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EPB12_RS02255	COG0762	integral membrane protein
EPB12_RS02260	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EPB12_RS02265	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EPB12_RS02285	COG1678	Uncharacterized ACR, COG1678
EPB12_RS02290	COG0189	ligase activity
EPB12_RS02295	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EPB12_RS02300	COG2356	endonuclease I
EPB12_RS02315	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EPB12_RS02320	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EPB12_RS02340	COG0191	fructose-bisphosphate aldolase activity
EPB12_RS02345	COG0668	transmembrane transport
EPB12_RS02385	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
EPB12_RS02400	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EPB12_RS02415	COG0354	folic acid binding
EPB12_RS02420	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
EPB12_RS02430	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EPB12_RS02435	COG1595	DNA-templated transcription, initiation
EPB12_RS02455	COG0481	GTPase activity
EPB12_RS02465	COG0571	ribonuclease III activity
EPB12_RS02470	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EPB12_RS02475	COG1381	Involved in DNA repair and RecF pathway recombination
EPB12_RS02480	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
EPB12_RS02485	COG0736	holo-[acyl-carrier-protein] synthase activity
EPB12_RS02490	COG4999	Histidine kinase
EPB12_RS02490	COG3850	Histidine kinase
EPB12_RS02490	COG3437	response regulator, receiver
EPB12_RS02490	COG2205	protein histidine kinase activity
EPB12_RS02500	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EPB12_RS02505	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EPB12_RS02550	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
EPB12_RS02555	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EPB12_RS02565	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EPB12_RS02570	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EPB12_RS02575	COG1546	Belongs to the CinA family
EPB12_RS02580	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EPB12_RS02610	COG0527	aspartate kinase activity
EPB12_RS02670	COG3630	sodium ion export across plasma membrane
EPB12_RS02675	COG0511	ligase activity, forming carbon-carbon bonds
EPB12_RS02675	COG5016	pyruvate
EPB12_RS02680	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
EPB12_RS02690	COG1238	metal cluster binding
EPB12_RS02695	COG0612	Peptidase, M16
EPB12_RS02710	COG1854	S-ribosylhomocysteine lyase activity
EPB12_RS02715	COG4536	flavin adenine dinucleotide binding
EPB12_RS02720	COG4137	Cytochrome C assembly protein
EPB12_RS02725	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EPB12_RS02735	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EPB12_RS02740	COG0336	Belongs to the RNA methyltransferase TrmD family
EPB12_RS02745	COG0335	large ribosomal subunit rRNA binding
EPB12_RS02750	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
EPB12_RS02755	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
EPB12_RS02760	COG0237	dephospho-CoA kinase activity
EPB12_RS02770	COG1459	type II secretion system
EPB12_RS02785	COG0157	Belongs to the NadC ModD family
EPB12_RS02800	COG2186	Transcriptional regulator
EPB12_RS02805	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
EPB12_RS02810	COG0508	dehydrogenase complex catalyzes the overall conversion of
EPB12_RS02815	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EPB12_RS02830	COG0288	reversible hydration of carbon dioxide
EPB12_RS02835	COG0659	secondary active sulfate transmembrane transporter activity
EPB12_RS02840	COG1131	(ABC) transporter
EPB12_RS02845	COG0842	Transport permease protein
EPB12_RS02850	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EPB12_RS02855	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EPB12_RS02860	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EPB12_RS02880	COG1489	DNA binding
EPB12_RS02885	COG1643	Atp-dependent helicase
EPB12_RS02890	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EPB12_RS02895	COG1752	Esterase of the alpha-beta hydrolase superfamily
EPB12_RS02900	COG1049	propionate catabolic process, 2-methylcitrate cycle
EPB12_RS02915	COG0004	ammonium transporteR
EPB12_RS02920	COG1840	ABC-type Fe3 transport system, periplasmic component
EPB12_RS02930	COG3842	ATPase activity
EPB12_RS02935	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EPB12_RS02950	COG2971	BadF BadG BcrA BcrD
EPB12_RS02960	COG4608	Belongs to the ABC transporter superfamily
EPB12_RS02965	COG0444	Belongs to the ABC transporter superfamily
EPB12_RS02970	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EPB12_RS02980	COG0747	negative chemotaxis
EPB12_RS02985	COG2205	protein histidine kinase activity
EPB12_RS02985	COG0784	Response regulator, receiver
EPB12_RS02990	COG2813	Specifically methylates the guanine in position
EPB12_RS02995	COG0628	permease
EPB12_RS03000	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EPB12_RS03005	COG0316	Belongs to the HesB IscA family
EPB12_RS03020	COG0739	heme binding
EPB12_RS03025	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EPB12_RS03030	COG2239	Acts as a magnesium transporter
EPB12_RS03035	COG2027	D-alanyl-D-alanine carboxypeptidase
EPB12_RS03040	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EPB12_RS03045	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EPB12_RS03050	COG1534	Rna-binding protein
EPB12_RS03055	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
EPB12_RS03060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EPB12_RS03065	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EPB12_RS03070	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EPB12_RS03080	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EPB12_RS03095	COG0779	Required for maturation of 30S ribosomal subunits
EPB12_RS03100	COG0195	Participates in both transcription termination and antitermination
EPB12_RS03105	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EPB12_RS03110	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EPB12_RS03115	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EPB12_RS03120	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EPB12_RS03140	COG0534	Mate efflux family protein
EPB12_RS03145	COG0826	peptidase U32
EPB12_RS03150	COG0826	peptidase U32
EPB12_RS03160	COG3154	lipid carrier protein
EPB12_RS03165	COG3153	acetyltransferase
EPB12_RS03180	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
EPB12_RS03200	COG0084	hydrolase, TatD family'
EPB12_RS03205	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EPB12_RS03210	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EPB12_RS03215	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
EPB12_RS03225	COG0813	purine-nucleoside phosphorylase activity
EPB12_RS03235	COG0560	Phosphoserine phosphatase
EPB12_RS03245	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EPB12_RS03250	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EPB12_RS03260	COG4628	conserved protein (DUF2132)
EPB12_RS03265	COG1022	Amp-dependent synthetase and ligase
EPB12_RS03295	COG4964	Belongs to the GSP D family
EPB12_RS03360	COG2059	Chromate
EPB12_RS03365	COG0583	DNA-binding transcription factor activity
EPB12_RS03370	COG0534	Mate efflux family protein
EPB12_RS03375	COG3408	Glycogen debranching enzyme
EPB12_RS03375	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
EPB12_RS03385	COG0531	amino acid
EPB12_RS03390	COG0531	amino acid
EPB12_RS03395	COG2731	YhcH YjgK YiaL family protein
EPB12_RS03400	COG3250	beta-galactosidase activity
EPB12_RS03405	COG1609	Transcriptional regulator
EPB12_RS03410	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EPB12_RS03415	COG1085	galactose-1-phosphate uridylyltransferase
EPB12_RS03425	COG2017	converts alpha-aldose to the beta-anomer
EPB12_RS03430	COG1609	Transcriptional regulator
EPB12_RS03435	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EPB12_RS03450	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EPB12_RS03470	COG2195	Cleaves the N-terminal amino acid of tripeptides
EPB12_RS03475	COG2252	PERMEase
EPB12_RS03480	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
EPB12_RS03485	COG1073	alpha beta
EPB12_RS03500	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EPB12_RS03505	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EPB12_RS03510	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EPB12_RS03510	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EPB12_RS03530	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EPB12_RS03535	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
EPB12_RS03550	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EPB12_RS03555	COG0142	geranyltranstransferase activity
EPB12_RS03560	COG1722	exodeoxyribonuclease VII activity
EPB12_RS03565	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EPB12_RS03575	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EPB12_RS03575	COG0301	tRNA thio-modification
EPB12_RS03580	COG0583	DNA-binding transcription factor activity
EPB12_RS03590	COG2363	Small membrane protein
EPB12_RS03595	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
EPB12_RS03605	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EPB12_RS03610	COG1611	Belongs to the LOG family
EPB12_RS03625	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EPB12_RS03625	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EPB12_RS03635	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
EPB12_RS03640	COG1464	Belongs to the NlpA lipoprotein family
EPB12_RS03645	COG2011	ABC-type metal ion transport system permease component
EPB12_RS03650	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EPB12_RS03655	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EPB12_RS03665	COG1609	Transcriptional regulator
EPB12_RS03670	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EPB12_RS03670	COG1263	PTS System
EPB12_RS03675	COG0366	Alpha amylase catalytic
EPB12_RS03730	COG1720	tRNA m6t6A37 methyltransferase activity
EPB12_RS03735	COG0254	rRNA binding
EPB12_RS03745	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
EPB12_RS03755	COG1671	Belongs to the UPF0178 family
EPB12_RS03780	COG3098	single-species biofilm formation
EPB12_RS03785	COG0564	pseudouridine synthase activity
EPB12_RS03795	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
EPB12_RS03800	COG0024	Methionine aminopeptidase
EPB12_RS03805	COG0052	Belongs to the universal ribosomal protein uS2 family
EPB12_RS03810	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EPB12_RS03815	COG0528	UMP kinase activity
EPB12_RS03820	COG0233	cytoplasmic translational termination
EPB12_RS03825	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EPB12_RS03830	COG0575	Belongs to the CDS family
EPB12_RS03840	COG0750	zinc metalloprotease
EPB12_RS03850	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
EPB12_RS03855	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EPB12_RS03860	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EPB12_RS03865	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EPB12_RS03875	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EPB12_RS03880	COG0587	DNA-directed DNA polymerase activity
EPB12_RS03885	COG0825	malonyl-CoA metabolic process
EPB12_RS03890	COG0037	tRNA processing
EPB12_RS03900	COG0347	Belongs to the P(II) protein family
EPB12_RS03905	COG3021	interspecies interaction between organisms
EPB12_RS03915	COG0741	lytic transglycosylase activity
EPB12_RS03915	COG1388	LysM domain
EPB12_RS03920	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EPB12_RS03925	COG2226	methyltransferase
EPB12_RS03930	COG0328	RNA-DNA hybrid ribonuclease activity
EPB12_RS03935	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EPB12_RS03945	COG1960	acyl-CoA dehydrogenase activity
EPB12_RS03955	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EPB12_RS03965	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EPB12_RS03970	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EPB12_RS04000	COG1393	Belongs to the ArsC family
EPB12_RS04005	COG4783	chaperone-mediated protein folding
EPB12_RS04020	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EPB12_RS04025	COG2716	regulation of RNA biosynthetic process
EPB12_RS04030	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EPB12_RS04035	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
EPB12_RS04050	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EPB12_RS04055	COG1393	Belongs to the ArsC family
EPB12_RS04080	COG2837	iron assimilation
EPB12_RS04090	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EPB12_RS04095	COG2190	(PTS) system
EPB12_RS04100	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EPB12_RS04105	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EPB12_RS04115	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
EPB12_RS04125	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EPB12_RS04145	COG0789	Transcriptional regulator
EPB12_RS04155	COG0330	HflC and HflK could
EPB12_RS04160	COG3118	belongs to the thioredoxin family
EPB12_RS04165	COG0300	oxidoreductase activity
EPB12_RS04170	COG1090	epimerase
EPB12_RS04195	COG0622	Phosphoesterase
EPB12_RS04215	COG3710	Transcriptional regulator
EPB12_RS04220	COG0326	Molecular chaperone. Has ATPase activity
EPB12_RS04225	COG0563	adenylate kinase activity
EPB12_RS04230	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EPB12_RS04235	COG3104	oligopeptide transport
EPB12_RS04240	COG0250	Participates in transcription elongation, termination and antitermination
EPB12_RS04245	COG0367	asparagine synthase
EPB12_RS04250	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EPB12_RS04250	COG4651	solute:proton antiporter activity
EPB12_RS04255	COG1940	carbohydrate kinase activity
EPB12_RS04255	COG1846	Transcriptional regulator
EPB12_RS04260	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EPB12_RS04265	COG1263	PTS System
EPB12_RS04265	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EPB12_RS04270	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EPB12_RS04300	COG0596	Alpha beta hydrolase
EPB12_RS04305	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
EPB12_RS04310	COG0033	Phosphoglucomutase
EPB12_RS04320	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EPB12_RS04335	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
EPB12_RS04340	COG1121	(ABC) transporter
EPB12_RS04345	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EPB12_RS04355	COG0045	succinate-CoA ligase (ADP-forming) activity
EPB12_RS04360	COG0508	dehydrogenase complex catalyzes the overall conversion of
EPB12_RS04365	COG0567	Dehydrogenase, E1 component
EPB12_RS04370	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EPB12_RS04375	COG1053	succinate dehydrogenase
EPB12_RS04380	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
EPB12_RS04425	COG0018	arginyl-trna synthetase
EPB12_RS04435	COG0788	formyltetrahydrofolate deformylase activity
EPB12_RS04445	COG1199	ATP-dependent helicase activity
EPB12_RS04450	COG1214	PFAM Peptidase M22, glycoprotease
EPB12_RS04465	COG0596	Alpha beta hydrolase
EPB12_RS04470	COG0318	PFAM AMP-dependent synthetase and ligase
EPB12_RS04480	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
EPB12_RS04485	COG2894	cell division
EPB12_RS04495	COG3100	YcgL domain-containing protein
EPB12_RS04500	COG2951	lytic endotransglycosylase activity
EPB12_RS04505	COG0583	DNA-binding transcription factor activity
EPB12_RS04510	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EPB12_RS04520	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EPB12_RS04530	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EPB12_RS04535	COG2860	membrane
EPB12_RS04540	COG3101	peptidyl-lysine hydroxylation
EPB12_RS04550	COG0431	NADPH-dependent FMN reductase
EPB12_RS04560	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EPB12_RS04570	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EPB12_RS04575	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EPB12_RS04585	COG0101	tRNA pseudouridine synthase activity
EPB12_RS04595	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EPB12_RS04600	COG0285	dihydrofolate synthase activity
EPB12_RS04605	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
EPB12_RS04610	COG1286	toxin biosynthetic process
EPB12_RS04615	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EPB12_RS04620	COG0583	DNA-binding transcription factor activity
EPB12_RS04630	COG2832	Protein of unknown function (DUF454)
EPB12_RS04635	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EPB12_RS04645	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EPB12_RS04650	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EPB12_RS04665	COG2983	Belongs to the UPF0260 family
EPB12_RS04670	COG1785	Belongs to the alkaline phosphatase family
EPB12_RS04690	COG2226	methyltransferase
EPB12_RS04705	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EPB12_RS04710	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EPB12_RS04720	COG3139	Protein of unknown function (DUF1315)
EPB12_RS04725	COG0252	asparaginase activity
EPB12_RS04730	COG0616	signal peptide processing
EPB12_RS04740	COG0446	pyridine nucleotide-disulphide oxidoreductase
EPB12_RS04740	COG1902	pentaerythritol trinitrate reductase activity
EPB12_RS04745	COG0778	Nitroreductase
EPB12_RS04750	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EPB12_RS04765	COG0123	including yeast histone deacetylase and acetoin utilization protein
EPB12_RS04830	COG3083	sulfuric ester hydrolase activity
EPB12_RS04835	COG3082	Protein of unknown function (DUF1414)
EPB12_RS04840	COG3081	Nucleoid-associated protein
EPB12_RS04855	COG1757	Na H antiporter
EPB12_RS04860	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EPB12_RS04870	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EPB12_RS04875	COG2095	MarC family integral membrane protein
EPB12_RS04880	COG1454	alcohol dehydrogenase
EPB12_RS04880	COG1012	belongs to the aldehyde dehydrogenase family
EPB12_RS04900	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EPB12_RS04910	COG2056	Na+-H+ antiporter family
EPB12_RS04930	COG0346	lactoylglutathione lyase activity
EPB12_RS04935	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EPB12_RS04940	COG4660	Part of a membrane complex involved in electron transport
EPB12_RS04945	COG4659	FMN binding
EPB12_RS04950	COG4658	electron transport chain
EPB12_RS04955	COG4656	Part of a membrane complex involved in electron transport
EPB12_RS04960	COG2878	Part of a membrane complex involved in electron transport
EPB12_RS04965	COG4657	Part of a membrane complex involved in electron transport
EPB12_RS04970	COG3710	Transcriptional regulator
EPB12_RS04970	COG0457	Tetratricopeptide repeat
EPB12_RS05005	COG0556	nucleotide-excision repair
EPB12_RS05010	COG2204	response regulator
EPB12_RS05015	COG2198	Histidine kinase
EPB12_RS05020	COG0391	Required for morphogenesis under gluconeogenic growth conditions
EPB12_RS05025	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EPB12_RS05030	COG0521	Mo-molybdopterin cofactor biosynthetic process
EPB12_RS05035	COG0315	cyclic pyranopterin monophosphate synthase activity
EPB12_RS05040	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
EPB12_RS05045	COG0314	molybdopterin synthase activity
EPB12_RS05055	COG0601	transmembrane transport
EPB12_RS05060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EPB12_RS05065	COG0444	Belongs to the ABC transporter superfamily
EPB12_RS05075	COG0435	Glutathione S-transferase
EPB12_RS05080	COG3706	GGDEF domain
EPB12_RS05085	COG0857	belongs to the CobB CobQ family
EPB12_RS05085	COG0280	phosphate acetyltransferase
EPB12_RS05095	COG3092	negative regulation of chromosome organization
EPB12_RS05105	COG3706	GGDEF domain
EPB12_RS05110	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EPB12_RS05115	COG0653	protein targeting
EPB12_RS05125	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EPB12_RS05130	COG2186	Transcriptional regulator
EPB12_RS05140	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EPB12_RS05140	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EPB12_RS05145	COG0489	protein tyrosine kinase activity
EPB12_RS05150	COG0572	uridine kinase
EPB12_RS05160	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
EPB12_RS05170	COG0659	secondary active sulfate transmembrane transporter activity
EPB12_RS05180	COG0564	pseudouridine synthase activity
EPB12_RS05190	COG1399	metal-binding, possibly nucleic acid-binding protein
EPB12_RS05195	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EPB12_RS05200	COG0416	fatty acid biosynthetic process
EPB12_RS05235	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EPB12_RS05240	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EPB12_RS05245	COG0470	DNA polymerase III
EPB12_RS05250	COG0084	hydrolase, TatD family'
EPB12_RS05275	COG4667	esterase of the alpha-beta hydrolase superfamily
EPB12_RS05280	COG0469	pyruvate kinase activity
EPB12_RS05285	COG1940	carbohydrate kinase activity
EPB12_RS05290	COG0835	chemotaxis
EPB12_RS05290	COG0784	Response regulator, receiver
EPB12_RS05305	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EPB12_RS05310	COG1028	Short-chain dehydrogenase reductase Sdr
EPB12_RS05315	COG0616	signal peptide processing
EPB12_RS05320	COG2719	SpoVR family
EPB12_RS05325	COG2718	Belongs to the UPF0229 family
EPB12_RS05330	COG2766	serine protein kinase
EPB12_RS05335	COG3713	MltA-interacting MipA family protein
EPB12_RS05345	COG3013	Belongs to the UPF0304 family
EPB12_RS05350	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EPB12_RS05360	COG1882	Formate acetyltransferase
EPB12_RS05395	COG0708	Exodeoxyribonuclease III
EPB12_RS05405	COG2814	Major facilitator Superfamily
EPB12_RS05415	COG2850	peptidyl-arginine hydroxylation
EPB12_RS05435	COG1199	ATP-dependent helicase activity
EPB12_RS05440	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EPB12_RS05445	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
EPB12_RS05450	COG1187	pseudouridine synthase activity
EPB12_RS05460	COG1278	Cold shock
EPB12_RS05465	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
EPB12_RS05470	COG0542	response to heat
EPB12_RS05480	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EPB12_RS05490	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
EPB12_RS05500	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EPB12_RS05510	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EPB12_RS05520	COG0297	glycogen (starch) synthase activity
EPB12_RS05545	COG3070	regulator of competence-specific genes
EPB12_RS05550	COG1609	Transcriptional regulator
EPB12_RS05555	COG3381	protein complex oligomerization
EPB12_RS05560	COG0745	RESPONSE REGULATOR receiver
EPB12_RS05565	COG1434	Gram-negative-bacterium-type cell wall biogenesis
EPB12_RS05570	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EPB12_RS05575	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
EPB12_RS05580	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
EPB12_RS05615	COG4106	trans-aconitate 2-methyltransferase activity
EPB12_RS05625	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EPB12_RS05635	COG0840	transmembrane signaling receptor activity
EPB12_RS05640	COG0632	four-way junction helicase activity
EPB12_RS05645	COG2255	four-way junction helicase activity
EPB12_RS05650	COG1271	oxidase subunit
EPB12_RS05655	COG1294	oxidase, subunit
EPB12_RS05660	COG4890	Cyd operon protein YbgT
EPB12_RS05670	COG0824	Thioesterase
EPB12_RS05675	COG0811	peptide transport
EPB12_RS05690	COG0823	Involved in the tonB-independent uptake of proteins
EPB12_RS05695	COG2885	chlorophyll binding
EPB12_RS05700	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
EPB12_RS05705	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EPB12_RS05720	COG5002	protein histidine kinase activity
EPB12_RS05720	COG0784	Response regulator, receiver
EPB12_RS05735	COG0786	glutamate:sodium symporter activity
EPB12_RS05765	COG0741	lytic transglycosylase activity
EPB12_RS05800	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EPB12_RS05820	COG0583	DNA-binding transcription factor activity
EPB12_RS05825	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EPB12_RS05845	COG0745	RESPONSE REGULATOR receiver
EPB12_RS05850	COG0463	Glycosyl transferase, family 2
EPB12_RS05880	COG0583	DNA-binding transcription factor activity
EPB12_RS05900	COG2350	Protein conserved in bacteria
EPB12_RS05905	COG1607	acyl-coa hydrolase
EPB12_RS05925	COG5001	Diguanylate cyclase
EPB12_RS05925	COG4251	negative regulation of phosphorylation
EPB12_RS05925	COG3706	GGDEF domain
EPB12_RS05925	COG2203	Gaf domain
EPB12_RS05930	COG0840	transmembrane signaling receptor activity
EPB12_RS05950	COG1301	dicarboxylic acid transport
EPB12_RS05960	COG0330	HflC and HflK could
EPB12_RS05965	COG0159	tryptophan synthase activity
EPB12_RS05970	COG0133	tryptophan synthase activity
EPB12_RS05975	COG0135	phosphoribosylanthranilate isomerase activity
EPB12_RS05975	COG0134	indole-3-glycerol-phosphate synthase activity
EPB12_RS05980	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EPB12_RS05985	COG0512	Glutamine amidotransferase of anthranilate synthase
EPB12_RS05990	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EPB12_RS06000	COG0613	PHP domain protein
EPB12_RS06005	COG0009	L-threonylcarbamoyladenylate synthase
EPB12_RS06040	COG2197	response regulator
EPB12_RS06115	COG3302	dmso reductase anchor subunit
EPB12_RS06120	COG0437	4 iron, 4 sulfur cluster binding
EPB12_RS06125	COG0243	molybdopterin cofactor binding
EPB12_RS06130	COG3381	protein complex oligomerization
EPB12_RS06145	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EPB12_RS06150	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EPB12_RS06155	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EPB12_RS06180	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
EPB12_RS06185	COG0437	4 iron, 4 sulfur cluster binding
EPB12_RS06190	COG3301	Polysulphide reductase, NrfD
EPB12_RS06205	COG3088	subunit of a heme lyase
EPB12_RS06205	COG4235	cytochrome complex assembly
EPB12_RS06210	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EPB12_RS06235	COG2989	Protein conserved in bacteria
EPB12_RS06240	COG3108	Peptidase M15
EPB12_RS06245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EPB12_RS06285	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EPB12_RS06290	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EPB12_RS06295	COG0840	transmembrane signaling receptor activity
EPB12_RS06320	COG5001	Diguanylate cyclase
EPB12_RS06320	COG5002	protein histidine kinase activity
EPB12_RS06335	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EPB12_RS06345	COG0492	ferredoxin-NADP+ reductase activity
EPB12_RS06375	COG3550	peptidyl-serine autophosphorylation
EPB12_RS06385	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EPB12_RS06400	COG2199	diguanylate cyclase activity
EPB12_RS06420	COG0471	metal ion transport
EPB12_RS06425	COG2949	membrane
EPB12_RS06430	COG0281	malic enzyme
EPB12_RS06435	COG1643	Atp-dependent helicase
EPB12_RS06445	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EPB12_RS06480	COG0277	FAD linked oxidase domain protein
EPB12_RS06480	COG0247	lactate metabolic process
EPB12_RS06500	COG2986	histidine ammonia-lyase
EPB12_RS06505	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
EPB12_RS06510	COG0010	Belongs to the arginase family
EPB12_RS06535	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EPB12_RS06545	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EPB12_RS06550	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EPB12_RS06555	COG3097	Belongs to the UPF0267 family
EPB12_RS06570	COG0488	(ABC) transporter
EPB12_RS06575	COG1309	transcriptional regulator
EPB12_RS06585	COG2226	methyltransferase
EPB12_RS06590	COG1166	arginine decarboxylase activity
EPB12_RS06595	COG0010	Belongs to the arginase family
EPB12_RS06615	COG0800	Aldolase
EPB12_RS06620	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EPB12_RS06625	COG1917	Cupin 2, conserved barrel domain protein
EPB12_RS06650	COG2186	Transcriptional regulator
EPB12_RS06655	COG2186	Transcriptional regulator
EPB12_RS06660	COG0517	IMP dehydrogenase activity
EPB12_RS06665	COG2176	DNA-directed DNA polymerase activity
EPB12_RS06685	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EPB12_RS06710	COG3033	Beta-eliminating lyase
EPB12_RS06735	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
EPB12_RS06755	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EPB12_RS06760	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EPB12_RS06765	COG0302	gtp cyclohydrolase
EPB12_RS06780	COG3243	poly(R)-hydroxyalkanoic acid synthase
EPB12_RS06840	COG0251	oxidation-reduction process
EPB12_RS06860	COG0730	response to heat
EPB12_RS06875	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
EPB12_RS06880	COG1280	lysine exporter protein (LysE YggA)
EPB12_RS06900	COG1115	amino acid carrier protein
EPB12_RS06915	COG1115	amino acid carrier protein
EPB12_RS06930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EPB12_RS06945	COG3290	protein histidine kinase activity
EPB12_RS06950	COG4565	transcriptional regulatory protein
EPB12_RS06955	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EPB12_RS06960	COG0363	glucosamine-6-phosphate deaminase activity
EPB12_RS06965	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
EPB12_RS06980	COG4628	conserved protein (DUF2132)
EPB12_RS07020	COG3437	response regulator, receiver
EPB12_RS07030	COG0515	serine threonine protein kinase
EPB12_RS07030	COG2815	serine threonine protein kinase
EPB12_RS07135	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
EPB12_RS07140	COG1470	cell adhesion involved in biofilm formation
EPB12_RS07140	COG1388	LysM domain
EPB12_RS07165	COG2272	Belongs to the type-B carboxylesterase lipase family
EPB12_RS07170	COG0457	Tetratricopeptide repeat
EPB12_RS07170	COG3710	Transcriptional regulator
EPB12_RS07185	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
EPB12_RS07190	COG0372	Belongs to the citrate synthase family
EPB12_RS07195	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EPB12_RS07200	COG2828	Protein conserved in bacteria
EPB12_RS07230	COG0561	phosphatase activity
EPB12_RS07235	COG0602	queuosine metabolic process
EPB12_RS07335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EPB12_RS07335	COG2198	Histidine kinase
EPB12_RS07335	COG2205	protein histidine kinase activity
EPB12_RS07335	COG0784	Response regulator, receiver
EPB12_RS07375	COG2885	chlorophyll binding
EPB12_RS07440	COG0840	transmembrane signaling receptor activity
EPB12_RS07445	COG1254	Belongs to the acylphosphatase family
EPB12_RS07450	COG2920	part of a sulfur-relay system
EPB12_RS07455	COG0670	Belongs to the BI1 family
EPB12_RS07460	COG1126	abc transporter atp-binding protein
EPB12_RS07465	COG0765	amino acid transport
EPB12_RS07470	COG4597	amino acid ABC transporter
EPB12_RS07475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EPB12_RS07485	COG1666	GTP binding
EPB12_RS07490	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EPB12_RS07495	COG0574	Belongs to the PEP-utilizing enzyme family
EPB12_RS07495	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EPB12_RS07510	COG2996	Protein conserved in bacteria
EPB12_RS07515	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
EPB12_RS07515	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EPB12_RS07525	COG3008	intermembrane lipid transfer
EPB12_RS07530	COG2995	paraquat-inducible protein a
EPB12_RS07535	COG1132	(ABC) transporter
EPB12_RS07540	COG1956	GAF domain-containing protein
EPB12_RS07545	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
EPB12_RS07560	COG0308	aminopeptidase N
EPB12_RS07570	COG2902	Dehydrogenase
EPB12_RS07575	COG0167	dihydroorotate dehydrogenase activity
EPB12_RS07585	COG0116	Belongs to the methyltransferase superfamily
EPB12_RS07585	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EPB12_RS07595	COG0488	(ABC) transporter
EPB12_RS07615	COG1067	ATP-dependent peptidase activity
EPB12_RS07620	COG3120	sequence-specific DNA binding
EPB12_RS07665	COG3278	Belongs to the heme-copper respiratory oxidase family
EPB12_RS07680	COG2010	Cytochrome c
EPB12_RS07690	COG2217	Heavy metal translocating P-type atpase
EPB12_RS07705	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EPB12_RS07710	COG0589	response to stress
EPB12_RS07715	COG0037	tRNA processing
EPB12_RS07745	COG1177	transmembrane transport
EPB12_RS07755	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EPB12_RS07785	COG0437	4 iron, 4 sulfur cluster binding
EPB12_RS07790	COG0243	molybdopterin cofactor binding
EPB12_RS07790	COG3383	formate dehydrogenase (NAD+) activity
EPB12_RS07800	COG3381	protein complex oligomerization
EPB12_RS07820	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EPB12_RS07830	COG0488	(ABC) transporter
EPB12_RS07850	COG4191	Histidine kinase
EPB12_RS07855	COG2204	response regulator
EPB12_RS07865	COG4662	Binding-protein-dependent transport system inner membrane component
EPB12_RS07870	COG3842	ATPase activity
EPB12_RS07875	COG0746	molybdenum cofactor guanylyltransferase activity
EPB12_RS07880	COG0303	'Molybdopterin
EPB12_RS07890	COG1940	carbohydrate kinase activity
EPB12_RS07895	COG3148	PFAM DTW domain containing protein
EPB12_RS07905	COG2964	Protein conserved in bacteria
EPB12_RS07910	COG3681	Belongs to the UPF0597 family
EPB12_RS07915	COG0251	oxidation-reduction process
EPB12_RS07930	COG0840	transmembrane signaling receptor activity
EPB12_RS07935	COG0791	NLP P60 protein
EPB12_RS07945	COG3001	Fructosamine kinase
EPB12_RS07955	COG0307	riboflavin synthase, alpha
EPB12_RS07965	COG0534	Mate efflux family protein
EPB12_RS07980	COG2885	chlorophyll binding
EPB12_RS07980	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
EPB12_RS08000	COG4176	ABC-type proline glycine betaine transport system permease component
EPB12_RS08005	COG3448	diguanylate cyclase activity
EPB12_RS08005	COG4175	Glycine betaine
EPB12_RS08015	COG2204	response regulator
EPB12_RS08020	COG0438	transferase activity, transferring glycosyl groups
EPB12_RS08050	COG1215	transferase activity, transferring glycosyl groups
EPB12_RS08055	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EPB12_RS08060	COG0583	DNA-binding transcription factor activity
EPB12_RS08085	COG1742	UPF0060 membrane protein
EPB12_RS08100	COG1247	-acetyltransferase
EPB12_RS08130	COG4160	amino acid transport
EPB12_RS08135	COG4215	(ABC) transporter
EPB12_RS08140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EPB12_RS08145	COG1126	abc transporter atp-binding protein
EPB12_RS08160	COG0826	peptidase U32
EPB12_RS08210	COG1028	Short-chain dehydrogenase reductase Sdr
EPB12_RS08220	COG0653	protein targeting
EPB12_RS08245	COG1619	proteins homologs of microcin C7 resistance protein MccF
EPB12_RS08275	COG0456	acetyltransferase
EPB12_RS08280	COG0346	lactoylglutathione lyase activity
EPB12_RS08290	COG1280	lysine exporter protein (LysE YggA)
EPB12_RS08325	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EPB12_RS08335	COG0307	riboflavin synthase, alpha
EPB12_RS08380	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EPB12_RS08380	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EPB12_RS08435	COG3547	Transposase (IS116 IS110 IS902 family)
EPB12_RS08450	COG0110	maltose O-acetyltransferase activity
EPB12_RS08465	COG0494	nUDIX hydrolase
EPB12_RS08490	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EPB12_RS08500	COG0584	glycerophosphoryl diester phosphodiesterase
EPB12_RS08540	COG0589	response to stress
EPB12_RS08550	COG3046	protein related to deoxyribodipyrimidine photolyase
EPB12_RS08565	COG0419	ATPase involved in DNA repair
EPB12_RS08570	COG0420	3'-5' exonuclease activity
EPB12_RS08605	COG0454	-acetyltransferase
EPB12_RS08610	COG2199	diguanylate cyclase activity
EPB12_RS08610	COG2203	Gaf domain
EPB12_RS08625	COG4771	TonB-dependent receptor
EPB12_RS08635	COG3469	chitinase activity
EPB12_RS08645	COG0840	transmembrane signaling receptor activity
EPB12_RS08665	COG0583	DNA-binding transcription factor activity
EPB12_RS08670	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EPB12_RS08675	COG3706	GGDEF domain
EPB12_RS08720	COG0455	bacterial-type flagellum organization
EPB12_RS08730	COG4964	Belongs to the GSP D family
EPB12_RS08750	COG0583	DNA-binding transcription factor activity
EPB12_RS08785	COG2195	Cleaves the N-terminal amino acid of tripeptides
EPB12_RS08800	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
EPB12_RS08805	COG3063	Type IV pilus biogenesis stability protein PilW
EPB12_RS08815	COG1451	nucleotide metabolic process
EPB12_RS08825	COG0583	DNA-binding transcription factor activity
EPB12_RS08830	COG2814	Major facilitator Superfamily
EPB12_RS08850	COG1247	-acetyltransferase
EPB12_RS08875	COG3397	chitin binding
EPB12_RS08885	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
EPB12_RS08890	COG4139	cobalamin transport
EPB12_RS08895	COG2988	succinylglutamate desuccinylase activity
EPB12_RS08915	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
EPB12_RS08920	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
EPB12_RS08925	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EPB12_RS08935	COG0702	epimerase
EPB12_RS08940	COG1823	symporter activity
EPB12_RS08950	COG4989	oxidoreductase activity
EPB12_RS08985	COG3122	Protein conserved in bacteria
EPB12_RS08990	COG3568	Endonuclease Exonuclease Phosphatase
EPB12_RS09045	COG2925	Exonuclease
EPB12_RS09055	COG1346	cytolysis
EPB12_RS09060	COG0295	cytidine deaminase activity
EPB12_RS09070	COG0500	methyltransferase
EPB12_RS09105	COG0776	regulation of translation
EPB12_RS09130	COG0523	cobalamin synthesis protein
EPB12_RS09140	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EPB12_RS09155	COG2207	Transcriptional regulator
EPB12_RS09155	COG3708	Transcriptional regulator
EPB12_RS09165	COG2175	clavaminate synthase activity
EPB12_RS09170	COG1404	Belongs to the peptidase S8 family
EPB12_RS09185	COG0596	Alpha beta hydrolase
EPB12_RS09205	COG2378	regulation of single-species biofilm formation
EPB12_RS09235	COG0776	regulation of translation
EPB12_RS09295	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
EPB12_RS09300	COG1346	cytolysis
EPB12_RS09310	COG0583	DNA-binding transcription factor activity
EPB12_RS09320	COG2200	EAL domain
EPB12_RS09340	COG0583	DNA-binding transcription factor activity
EPB12_RS09345	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EPB12_RS09370	COG2165	general secretion pathway protein
EPB12_RS09375	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
EPB12_RS09380	COG2873	o-acetylhomoserine
EPB12_RS09395	COG0784	Response regulator, receiver
EPB12_RS09395	COG2205	protein histidine kinase activity
EPB12_RS09420	COG1228	amidohydrolase
EPB12_RS09470	COG0072	phenylalanine-tRNA ligase activity
EPB12_RS09470	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EPB12_RS09475	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EPB12_RS09520	COG1643	Atp-dependent helicase
EPB12_RS09525	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
EPB12_RS09530	COG2223	nitrite transmembrane transporter activity
EPB12_RS09535	COG1063	alcohol dehydrogenase
EPB12_RS09570	COG3710	Transcriptional regulator
EPB12_RS09605	COG0443	Heat shock 70 kDa protein
EPB12_RS09630	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EPB12_RS09645	COG3106	COG3106 Predicted ATPase
EPB12_RS09675	COG0494	nUDIX hydrolase
EPB12_RS09680	COG0814	amino acid
EPB12_RS09685	COG1760	l-serine dehydratase
EPB12_RS09690	COG0814	amino acid
EPB12_RS09695	COG0840	transmembrane signaling receptor activity
EPB12_RS09700	COG0659	secondary active sulfate transmembrane transporter activity
EPB12_RS09705	COG0017	Asparaginyl-tRNA synthetase
EPB12_RS09715	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EPB12_RS09725	COG2770	Histidine kinase
EPB12_RS09725	COG3437	response regulator, receiver
EPB12_RS09730	COG1448	Aminotransferase
EPB12_RS09750	COG2258	MOSC domain
EPB12_RS09765	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
EPB12_RS09775	COG4191	Histidine kinase
EPB12_RS09780	COG2204	response regulator
EPB12_RS09790	COG3070	regulator of competence-specific genes
EPB12_RS09800	COG2431	L-lysine efflux transmembrane transporter activity
EPB12_RS09815	COG1737	Transcriptional regulator
EPB12_RS09825	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EPB12_RS09830	COG2985	domain, Protein
EPB12_RS09830	COG3273	potassium ion transport
EPB12_RS09835	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EPB12_RS09860	COG2885	chlorophyll binding
EPB12_RS09860	COG3047	cAMP biosynthetic process
EPB12_RS09865	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EPB12_RS09885	COG0534	Mate efflux family protein
EPB12_RS09890	COG1858	cytochrome C peroxidase
EPB12_RS09895	COG0702	epimerase
EPB12_RS09905	COG2814	Major facilitator Superfamily
EPB12_RS09915	COG1061	Type III restriction enzyme res subunit
EPB12_RS09930	COG0642	Histidine kinase
EPB12_RS09950	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
EPB12_RS09970	COG3547	Transposase (IS116 IS110 IS902 family)
EPB12_RS10030	COG3547	Transposase (IS116 IS110 IS902 family)
EPB12_RS10065	COG0494	nUDIX hydrolase
EPB12_RS10090	COG2165	general secretion pathway protein
EPB12_RS10100	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EPB12_RS10115	COG1280	lysine exporter protein (LysE YggA)
EPB12_RS10175	COG3008	intermembrane lipid transfer
EPB12_RS10175	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EPB12_RS10180	COG2995	paraquat-inducible protein a
EPB12_RS10185	COG0583	DNA-binding transcription factor activity
EPB12_RS10205	COG0243	molybdopterin cofactor binding
EPB12_RS10210	COG3005	denitrification pathway
EPB12_RS10220	COG2866	Carboxypeptidase
EPB12_RS10230	COG1280	lysine exporter protein (LysE YggA)
EPB12_RS10235	COG0513	Belongs to the DEAD box helicase family
EPB12_RS10250	COG3313	Fe-S protein
EPB12_RS10260	COG4134	Bacterial extracellular solute-binding protein
EPB12_RS10265	COG4135	transport system, permease component
EPB12_RS10270	COG4136	ATPase activity
EPB12_RS10275	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EPB12_RS10280	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EPB12_RS10280	COG0116	Belongs to the methyltransferase superfamily
EPB12_RS10285	COG0564	pseudouridine synthase activity
EPB12_RS10295	COG0733	neurotransmitter:sodium symporter activity
EPB12_RS10305	COG0626	cystathionine gamma-synthase activity
EPB12_RS10320	COG2818	Glycosylase
EPB12_RS10335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EPB12_RS10340	COG1983	PspC domain protein
EPB12_RS10350	COG1842	Phage shock protein A
EPB12_RS10355	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
EPB12_RS10365	COG4168	peptide transport system, permease
EPB12_RS10380	COG4172	Belongs to the ABC transporter superfamily
EPB12_RS10395	COG1227	inorganic diphosphatase activity
EPB12_RS10405	COG0243	molybdopterin cofactor binding
EPB12_RS10410	COG3005	denitrification pathway
EPB12_RS10415	COG4459	periplasmic nitrate reductase
EPB12_RS10420	COG0390	transport system, permease component
EPB12_RS10485	COG2116	formate transmembrane transporter activity
EPB12_RS10515	COG0215	cysteine-tRNA ligase activity
EPB12_RS10520	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EPB12_RS10530	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EPB12_RS10535	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
EPB12_RS10540	COG3012	SEC-C Motif Domain Protein
EPB12_RS10545	COG0140	phosphoribosyl-ATP diphosphatase activity
EPB12_RS10545	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EPB12_RS10550	COG0107	imidazoleglycerol-phosphate synthase activity
EPB12_RS10555	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EPB12_RS10560	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EPB12_RS10565	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EPB12_RS10565	COG0131	Imidazoleglycerol-phosphate dehydratase
EPB12_RS10570	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EPB12_RS10585	COG1757	Na H antiporter
EPB12_RS10595	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EPB12_RS10610	COG2915	High frequency lysogenization protein hflD homolog
EPB12_RS10615	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EPB12_RS10620	COG0501	Belongs to the peptidase M48B family
EPB12_RS10625	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
EPB12_RS10635	COG0156	8-amino-7-oxononanoate synthase activity
EPB12_RS10640	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EPB12_RS10650	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EPB12_RS10655	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EPB12_RS10665	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EPB12_RS10670	COG1674	ftsk spoiiie
EPB12_RS10675	COG1522	sequence-specific DNA binding
EPB12_RS10680	COG0686	Belongs to the AlaDH PNT family
EPB12_RS10690	COG0583	DNA-binding transcription factor activity
EPB12_RS10705	COG0284	orotidine-5'-phosphate decarboxylase activity
EPB12_RS10710	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
EPB12_RS10715	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
EPB12_RS10720	COG0776	regulation of translation
EPB12_RS10725	COG0539	negative regulation of cytoplasmic translation
EPB12_RS10730	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EPB12_RS10735	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
EPB12_RS10740	COG2835	tetraacyldisaccharide 4'-kinase activity
EPB12_RS10745	COG1663	tetraacyldisaccharide 4'-kinase activity
EPB12_RS10750	COG1132	(ABC) transporter
EPB12_RS10755	COG2333	competence protein COMEC
EPB12_RS10755	COG0658	competence protein
EPB12_RS10765	COG4591	ABC-type transport system involved in lipoprotein release permease component
EPB12_RS10770	COG1136	(ABC) transporter
EPB12_RS10775	COG4591	ABC-type transport system involved in lipoprotein release permease component
EPB12_RS10785	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EPB12_RS10800	COG1252	NADH dehydrogenase
EPB12_RS10805	COG3150	esterase
EPB12_RS10830	COG0537	adenosine 5'-monophosphoramidase activity
EPB12_RS10860	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EPB12_RS10860	COG0617	tRNA 3'-terminal CCA addition
EPB12_RS10860	COG0517	IMP dehydrogenase activity
EPB12_RS10890	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EPB12_RS10895	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EPB12_RS10925	COG1902	pentaerythritol trinitrate reductase activity
EPB12_RS10930	COG0346	lactoylglutathione lyase activity
EPB12_RS10935	COG0583	DNA-binding transcription factor activity
EPB12_RS10960	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
EPB12_RS10965	COG1845	cytochrome c oxidase, subunit III
EPB12_RS10970	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EPB12_RS10975	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EPB12_RS10995	COG0583	DNA-binding transcription factor activity
EPB12_RS11010	COG3040	lipid binding
EPB12_RS11020	COG1228	amidohydrolase
EPB12_RS11030	COG1120	ATPase activity
EPB12_RS11035	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EPB12_RS11060	COG3227	Zinc metalloprotease (Elastase)
EPB12_RS11070	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
EPB12_RS11085	COG1227	inorganic diphosphatase activity
EPB12_RS11090	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EPB12_RS11095	COG0348	domain, Protein
EPB12_RS11105	COG0737	Belongs to the 5'-nucleotidase family
EPB12_RS11130	COG1522	sequence-specific DNA binding
EPB12_RS11135	COG1760	l-serine dehydratase
EPB12_RS11145	COG2814	Major facilitator Superfamily
EPB12_RS11160	COG1609	Transcriptional regulator
EPB12_RS11165	COG3119	arylsulfatase activity
EPB12_RS11190	COG0583	DNA-binding transcription factor activity
EPB12_RS11195	COG1486	melibiose metabolic process
EPB12_RS11200	COG3394	polysaccharide catabolic process
EPB12_RS11205	COG0789	Transcriptional regulator
EPB12_RS11210	COG0583	DNA-binding transcription factor activity
EPB12_RS11245	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EPB12_RS11260	COG0456	acetyltransferase
EPB12_RS11260	COG1214	PFAM Peptidase M22, glycoprotease
EPB12_RS11290	COG1216	Glycosyl transferase, family 2
EPB12_RS11290	COG0463	Glycosyl transferase, family 2
EPB12_RS11295	COG0438	transferase activity, transferring glycosyl groups
EPB12_RS11300	COG0328	RNA-DNA hybrid ribonuclease activity
EPB12_RS11300	COG3341	Caulimovirus viroplasmin
EPB12_RS11340	COG0438	transferase activity, transferring glycosyl groups
EPB12_RS11380	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EPB12_RS11425	COG1479	Protein of unknown function DUF262
EPB12_RS11435	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EPB12_RS11525	COG3126	Type III secretion system lipoprotein chaperone (YscW)
EPB12_RS11530	COG1946	Acyl-CoA thioesterase
EPB12_RS11540	COG1522	sequence-specific DNA binding
EPB12_RS11545	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EPB12_RS11560	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EPB12_RS11620	COG2855	membrane
EPB12_RS11630	COG2190	(PTS) system
EPB12_RS11630	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EPB12_RS11630	COG1263	PTS System
EPB12_RS11645	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
EPB12_RS11650	COG2267	carboxylic ester hydrolase activity
EPB12_RS11655	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
EPB12_RS11660	COG1169	isochorismate synthase
EPB12_RS11675	COG0232	Belongs to the dGTPase family. Type 2 subfamily
EPB12_RS11690	COG1555	photosystem II stabilization
EPB12_RS11695	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EPB12_RS11700	COG0776	regulation of translation
EPB12_RS11705	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EPB12_RS11710	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EPB12_RS11720	COG0544	peptidyl-prolyl cis-trans isomerase activity
EPB12_RS11730	COG2204	response regulator
EPB12_RS11735	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EPB12_RS11740	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
EPB12_RS11745	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EPB12_RS11750	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EPB12_RS11755	COG3842	ATPase activity
EPB12_RS11760	COG0395	ABC-type sugar transport system, permease component
EPB12_RS11765	COG1175	transmembrane transport
EPB12_RS11785	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EPB12_RS11790	COG1280	lysine exporter protein (LysE YggA)
EPB12_RS11800	COG2890	protein-(glutamine-N5) methyltransferase activity
EPB12_RS11805	COG2840	Smr protein MutS2
EPB12_RS11810	COG2062	phosphohistidine phosphatase, SixA
EPB12_RS11820	COG1024	Enoyl-CoA hydratase
EPB12_RS11820	COG1250	3-hydroxyacyl-CoA dehydrogenase
EPB12_RS11825	COG0183	Belongs to the thiolase family
EPB12_RS11840	COG2067	long-chain fatty acid transport protein
EPB12_RS11850	COG2853	Lipoprotein
EPB12_RS11855	COG4235	cytochrome complex assembly
EPB12_RS11855	COG3088	subunit of a heme lyase
EPB12_RS11860	COG4235	cytochrome complex assembly
EPB12_RS11860	COG3088	subunit of a heme lyase
EPB12_RS11865	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EPB12_RS11870	COG1138	Cytochrome C-type biogenesis protein
EPB12_RS11875	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
EPB12_RS11880	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EPB12_RS11885	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EPB12_RS11890	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EPB12_RS11895	COG4133	protoheme IX ABC transporter activity
EPB12_RS11905	COG0835	chemotaxis
EPB12_RS11915	COG1192	Involved in chromosome partitioning
EPB12_RS11920	COG2201	protein-glutamate methylesterase activity
EPB12_RS11925	COG2198	Histidine kinase
EPB12_RS11925	COG0643	Histidine kinase
EPB12_RS11925	COG0784	Response regulator, receiver
EPB12_RS11930	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
EPB12_RS11965	COG1684	flagellar biosynthetic protein fliR
EPB12_RS11970	COG1987	bacterial-type flagellum assembly
EPB12_RS12020	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EPB12_RS12030	COG1677	Flagellar hook-basal body complex protein FliE
EPB12_RS12050	COG1516	flagellar protein fliS
EPB12_RS12060	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
EPB12_RS12070	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EPB12_RS12075	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EPB12_RS12080	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EPB12_RS12095	COG1705	Flagellar rod assembly protein muramidase FlgJ
EPB12_RS12095	COG3951	Flagellar rod assembly protein muramidase FlgJ
EPB12_RS12100	COG1706	bacterial-type flagellum-dependent cell motility
EPB12_RS12105	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
EPB12_RS12115	COG4787	bacterial-type flagellum-dependent cell motility
EPB12_RS12120	COG1749	Flagellar hook protein flgE
EPB12_RS12135	COG1815	bacterial-type flagellum-dependent cell motility
EPB12_RS12140	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EPB12_RS12145	COG0784	Response regulator, receiver
EPB12_RS12145	COG0835	chemotaxis
EPB12_RS12150	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
EPB12_RS12210	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EPB12_RS12215	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EPB12_RS12235	COG1216	Glycosyl transferase, family 2
EPB12_RS12240	COG2986	histidine ammonia-lyase
EPB12_RS12275	COG1028	Short-chain dehydrogenase reductase Sdr
EPB12_RS12370	COG2840	Smr protein MutS2
EPB12_RS12375	COG1187	pseudouridine synthase activity
EPB12_RS12380	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EPB12_RS12390	COG2877	3-deoxy-8-phosphooctulonate synthase activity
EPB12_RS12395	COG2912	Transglutaminase-like superfamily
EPB12_RS12400	COG3094	Invasion gene expression up-regulator, SirB
EPB12_RS12410	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EPB12_RS12415	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EPB12_RS12425	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EPB12_RS12430	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EPB12_RS12545	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EPB12_RS12550	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EPB12_RS12555	COG1702	phosphate starvation-inducible protein PhoH
EPB12_RS12560	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EPB12_RS12570	COG0815	Transfers the fatty acyl group on membrane lipoproteins
EPB12_RS12575	COG2888	peptidyl-tyrosine sulfation
EPB12_RS12580	COG0495	leucyl-tRNA aminoacylation
EPB12_RS12585	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
EPB12_RS12590	COG1466	dna polymerase III delta subunit
EPB12_RS12595	COG0799	negative regulation of ribosome biogenesis
EPB12_RS12600	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EPB12_RS12605	COG0768	penicillin binding
EPB12_RS12610	COG0772	Belongs to the SEDS family
EPB12_RS12615	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EPB12_RS12620	COG1686	Belongs to the peptidase S11 family
EPB12_RS12630	COG0321	lipoyl(octanoyl) transferase activity
EPB12_RS12635	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EPB12_RS12640	COG0733	neurotransmitter:sodium symporter activity
EPB12_RS12650	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EPB12_RS12660	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EPB12_RS12665	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EPB12_RS12710	COG0210	DNA helicase
EPB12_RS12760	COG2991	Protein conserved in bacteria
EPB12_RS12765	COG1477	protein flavinylation
EPB12_RS12770	COG2871	sodium ion transport
EPB12_RS12775	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EPB12_RS12780	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EPB12_RS12790	COG1805	sodium ion transport
EPB12_RS12795	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EPB12_RS12800	COG0271	Belongs to the BolA IbaG family
EPB12_RS12805	COG2813	Specifically methylates the guanine in position
EPB12_RS12815	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EPB12_RS12830	COG3248	Nucleoside-binding outer membrane protein
EPB12_RS12835	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EPB12_RS12840	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EPB12_RS12850	COG2166	iron-sulfur cluster assembly
EPB12_RS12855	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EPB12_RS12860	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
EPB12_RS12870	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
EPB12_RS12870	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EPB12_RS12880	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EPB12_RS12885	COG1074	ATP-dependent DNA helicase activity
EPB12_RS12890	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
EPB12_RS12905	COG3141	response to X-ray
EPB12_RS12920	COG2095	MarC family integral membrane protein
EPB12_RS12925	COG2171	N-acyltransferase activity
EPB12_RS12935	COG0047	phosphoribosylformylglycinamidine synthase activity
EPB12_RS12935	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EPB12_RS12950	COG1253	flavin adenine dinucleotide binding
EPB12_RS12955	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
EPB12_RS12985	COG0484	heat shock protein binding
EPB12_RS12990	COG0443	Heat shock 70 kDa protein
EPB12_RS13000	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EPB12_RS13005	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EPB12_RS13015	COG0497	DNA recombination
EPB12_RS13020	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EPB12_RS13025	COG2914	Belongs to the UPF0125 (RnfH) family
EPB12_RS13030	COG2867	negative regulation of translational initiation
EPB12_RS13045	COG4067	protein conserved in archaea
EPB12_RS13045	COG0189	ligase activity
EPB12_RS13060	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EPB12_RS13070	COG0204	Acyl-transferase
EPB12_RS13075	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
EPB12_RS13080	COG1115	amino acid carrier protein
EPB12_RS13085	COG1584	GPR1 FUN34 yaaH family protein
EPB12_RS13090	COG1757	Na H antiporter
EPB12_RS13100	COG0519	Catalyzes the synthesis of GMP from XMP
EPB12_RS13100	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EPB12_RS13105	COG0516	GMP reductase activity
EPB12_RS13105	COG0517	IMP dehydrogenase activity
EPB12_RS13120	COG3706	GGDEF domain
EPB12_RS13125	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EPB12_RS13130	COG1160	GTP binding
EPB12_RS13135	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EPB12_RS13140	COG2976	Protein conserved in bacteria
EPB12_RS13145	COG0124	histidyl-tRNA synthetase
EPB12_RS13150	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EPB12_RS13155	COG1426	Protein conserved in bacteria
EPB12_RS13160	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EPB12_RS13165	COG0105	UTP biosynthetic process
EPB12_RS13170	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EPB12_RS13175	COG2975	iron-sulfur cluster assembly
EPB12_RS13185	COG0443	Heat shock 70 kDa protein
EPB12_RS13190	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
EPB12_RS13200	COG0822	iron-sulfur transferase activity
EPB12_RS13205	COG1104	cysteine desulfurase activity
EPB12_RS13210	COG1959	2 iron, 2 sulfur cluster binding
EPB12_RS13215	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
EPB12_RS13220	COG0483	inositol monophosphate 1-phosphatase activity
EPB12_RS13230	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EPB12_RS13235	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EPB12_RS13240	COG1862	Preprotein translocase
EPB12_RS13245	COG0343	queuine tRNA-ribosyltransferase activity
EPB12_RS13250	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EPB12_RS13255	COG0517	IMP dehydrogenase activity
EPB12_RS13260	COG0583	DNA-binding transcription factor activity
EPB12_RS13265	COG0450	alkyl hydroperoxide reductase
EPB12_RS13270	COG3142	Participates in the control of copper homeostasis
EPB12_RS13290	COG0704	Plays a role in the regulation of phosphate uptake
EPB12_RS13295	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EPB12_RS13305	COG0573	inorganic phosphate transmembrane transporter activity
EPB12_RS13310	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EPB12_RS13315	COG0248	Ppx GppA phosphatase
EPB12_RS13325	COG5002	protein histidine kinase activity
EPB12_RS13330	COG0745	RESPONSE REGULATOR receiver
EPB12_RS13335	COG2974	May be involved in recombination
EPB12_RS13340	COG0826	peptidase U32
EPB12_RS13345	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EPB12_RS13355	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
EPB12_RS13405	COG0564	pseudouridine synthase activity
EPB12_RS13410	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EPB12_RS13415	COG0741	lytic transglycosylase activity
EPB12_RS13420	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EPB12_RS13425	COG0077	Prephenate dehydratase
EPB12_RS13425	COG1605	Chorismate mutase
EPB12_RS13430	COG5001	Diguanylate cyclase
EPB12_RS13435	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
EPB12_RS13440	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
EPB12_RS13450	COG0488	(ABC) transporter
EPB12_RS13460	COG0739	heme binding
EPB12_RS13465	COG0287	Prephenate dehydrogenase
EPB12_RS13465	COG1605	Chorismate mutase
EPB12_RS13470	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EPB12_RS13480	COG1737	Transcriptional regulator
EPB12_RS13490	COG2971	BadF BadG BcrA BcrD
EPB12_RS13495	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EPB12_RS13500	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EPB12_RS13510	COG1966	Carbon starvation protein
EPB12_RS13520	COG3275	phosphorelay sensor kinase activity
EPB12_RS13525	COG3279	Response regulator of the LytR AlgR family
EPB12_RS13530	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EPB12_RS13535	COG1047	Peptidyl-prolyl cis-trans
EPB12_RS13545	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EPB12_RS13550	COG0196	riboflavin kinase activity
EPB12_RS13555	COG0728	peptidoglycan biosynthetic process
EPB12_RS13560	COG0268	Binds directly to 16S ribosomal RNA
EPB12_RS13565	COG0640	Transcriptional regulator
EPB12_RS13575	COG1283	sodium-dependent phosphate transmembrane transporter activity
EPB12_RS13585	COG0156	8-amino-7-oxononanoate synthase activity
EPB12_RS13625	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
EPB12_RS13630	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EPB12_RS13635	COG0730	response to heat
EPB12_RS13645	COG0494	nUDIX hydrolase
EPB12_RS13675	COG3290	protein histidine kinase activity
EPB12_RS13675	COG3829	transcription factor binding
EPB12_RS13680	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EPB12_RS13690	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EPB12_RS13695	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EPB12_RS13700	COG4974	Belongs to the 'phage' integrase family
EPB12_RS13705	COG0716	FMN binding
EPB12_RS13715	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
EPB12_RS13720	COG0513	Belongs to the DEAD box helicase family
EPB12_RS13725	COG3022	response to hydroperoxide
EPB12_RS13730	COG1115	amino acid carrier protein
EPB12_RS13745	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EPB12_RS13750	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
EPB12_RS13755	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
EPB12_RS13765	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
EPB12_RS13770	COG0083	homoserine kinase activity
EPB12_RS13785	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EPB12_RS13795	COG0745	RESPONSE REGULATOR receiver
EPB12_RS13805	COG2198	Histidine kinase
EPB12_RS13805	COG0784	Response regulator, receiver
EPB12_RS13805	COG5002	protein histidine kinase activity
EPB12_RS13810	COG3706	GGDEF domain
EPB12_RS13810	COG4251	negative regulation of phosphorylation
EPB12_RS13810	COG5001	Diguanylate cyclase
EPB12_RS13810	COG2203	Gaf domain
EPB12_RS13815	COG1242	4 iron, 4 sulfur cluster binding
EPB12_RS13820	COG0070	glutamate synthase
EPB12_RS13820	COG0069	glutamate synthase activity
EPB12_RS13820	COG0067	glutamate synthase
EPB12_RS13830	COG0067	glutamate synthase
EPB12_RS13830	COG0070	glutamate synthase
EPB12_RS13830	COG0069	glutamate synthase activity
EPB12_RS13835	COG0493	'glutamate synthase
EPB12_RS13845	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EPB12_RS13860	COG2860	membrane
EPB12_RS13870	COG0583	DNA-binding transcription factor activity
EPB12_RS13875	COG0730	response to heat
EPB12_RS13880	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EPB12_RS13885	COG0505	Belongs to the CarA family
EPB12_RS13890	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EPB12_RS13895	COG0494	nUDIX hydrolase
EPB12_RS13900	COG0653	protein targeting
EPB12_RS13905	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
EPB12_RS13910	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EPB12_RS13915	COG0849	cell division
EPB12_RS13920	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EPB12_RS13930	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EPB12_RS13935	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EPB12_RS13940	COG0772	Belongs to the SEDS family
EPB12_RS13945	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EPB12_RS13950	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EPB12_RS13955	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EPB12_RS13960	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EPB12_RS13965	COG0768	penicillin binding
EPB12_RS13970	COG3116	cell division
EPB12_RS13975	COG0275	rRNA processing
EPB12_RS13990	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EPB12_RS14005	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EPB12_RS14010	COG2823	Periplasmic or secreted lipoprotein
EPB12_RS14015	COG2969	positive regulation of protein catabolic process
EPB12_RS14020	COG0625	glutathione transferase activity
EPB12_RS14025	COG2857	Cytochrome c1
EPB12_RS14030	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EPB12_RS14035	COG0723	plastoquinol--plastocyanin reductase activity
EPB12_RS14040	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EPB12_RS14050	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
EPB12_RS14055	COG3105	Protein conserved in bacteria
EPB12_RS14065	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EPB12_RS14080	COG3150	esterase
EPB12_RS14090	COG3151	Protein conserved in bacteria
EPB12_RS14095	COG0494	nUDIX hydrolase
EPB12_RS14100	COG1538	Outer membrane efflux protein
EPB12_RS14105	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EPB12_RS14105	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
EPB12_RS14110	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
EPB12_RS14120	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EPB12_RS14125	COG3025	triphosphatase activity
EPB12_RS14130	COG1392	Phosphate transport regulator
EPB12_RS14135	COG0306	phosphate transporter
EPB12_RS14140	COG4991	sh3 domain protein
EPB12_RS14150	COG3267	Type II secretory pathway component ExeA
EPB12_RS14150	COG3409	Peptidoglycan-binding domain 1 protein
EPB12_RS14160	COG1968	undecaprenyl-diphosphatase activity
EPB12_RS14165	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EPB12_RS14170	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EPB12_RS14175	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EPB12_RS14195	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EPB12_RS14200	COG1610	YqeY-like protein
EPB12_RS14225	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EPB12_RS14230	COG1349	DNA-binding transcription factor activity
EPB12_RS14235	COG0469	pyruvate kinase activity
EPB12_RS14250	COG3706	GGDEF domain
EPB12_RS14260	COG0028	Belongs to the TPP enzyme family
EPB12_RS14265	COG1022	Amp-dependent synthetase and ligase
EPB12_RS14300	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EPB12_RS14305	COG0473	3-isopropylmalate dehydrogenase activity
EPB12_RS14315	COG0066	3-isopropylmalate dehydratase activity
EPB12_RS14330	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
EPB12_RS14335	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
EPB12_RS14340	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EPB12_RS14345	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EPB12_RS14350	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EPB12_RS14355	COG2967	ApaG domain
EPB12_RS14360	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EPB12_RS14380	COG2966	Psort location CytoplasmicMembrane, score
EPB12_RS14385	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EPB12_RS14390	COG0211	Belongs to the bacterial ribosomal protein bL27 family
EPB12_RS14395	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EPB12_RS14400	COG0142	geranyltranstransferase activity
EPB12_RS14410	COG0039	L-malate dehydrogenase activity
EPB12_RS14415	COG1438	arginine binding
EPB12_RS14420	COG2358	TRAP transporter, solute receptor (TAXI family
EPB12_RS14430	COG0589	response to stress
EPB12_RS14435	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EPB12_RS14440	COG0564	pseudouridine synthase activity
EPB12_RS14450	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EPB12_RS14455	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
EPB12_RS14460	COG0312	modulator of DNA gyrase
EPB12_RS14465	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EPB12_RS14480	COG0424	maF-like protein
EPB12_RS14485	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
EPB12_RS14490	COG1792	Involved in formation and maintenance of cell shape
EPB12_RS14495	COG1077	Cell shape determining protein MreB Mrl
EPB12_RS14525	COG2165	general secretion pathway protein
EPB12_RS14530	COG2165	general secretion pathway protein
EPB12_RS14615	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EPB12_RS14645	COG0629	single-stranded DNA binding
EPB12_RS14650	COG2197	response regulator
EPB12_RS14660	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EPB12_RS14670	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EPB12_RS14675	COG0527	aspartate kinase activity
EPB12_RS14680	COG1410	methionine synthase
EPB12_RS14680	COG0646	methionine synthase
EPB12_RS14755	COG0175	sulfate reduction
EPB12_RS14760	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EPB12_RS14765	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EPB12_RS14785	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EPB12_RS14790	COG0735	belongs to the Fur family
EPB12_RS14800	COG0166	Belongs to the GPI family
EPB12_RS14805	COG0432	Pfam Uncharacterised protein family UPF0047
EPB12_RS14815	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EPB12_RS14830	COG0359	binds to the 23S rRNA
EPB12_RS14850	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EPB12_RS14855	COG0557	exoribonuclease II activity
EPB12_RS14860	COG0402	S-adenosylhomocysteine deaminase activity
EPB12_RS14865	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
EPB12_RS14875	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EPB12_RS14880	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
EPB12_RS14885	COG0330	HflC and HflK could
EPB12_RS14890	COG0330	HflC and HflK could
EPB12_RS14895	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EPB12_RS14900	COG1923	regulation of RNA biosynthetic process
EPB12_RS14905	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EPB12_RS14910	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EPB12_RS14915	COG0860	N-Acetylmuramoyl-L-alanine amidase
EPB12_RS14920	COG0802	atpase or kinase
EPB12_RS14925	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EPB12_RS15005	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
EPB12_RS15010	COG1162	GTPase activity
EPB12_RS15025	COG0840	transmembrane signaling receptor activity
EPB12_RS15035	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
EPB12_RS15045	COG1053	succinate dehydrogenase
EPB12_RS15050	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EPB12_RS15055	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
EPB12_RS15080	COG0814	amino acid
EPB12_RS15085	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EPB12_RS15090	COG1509	lysine 2,3-aminomutase activity
EPB12_RS15105	COG2199	diguanylate cyclase activity
EPB12_RS15105	COG2203	Gaf domain
EPB12_RS15115	COG0459	protein refolding
EPB12_RS15125	COG0534	Mate efflux family protein
EPB12_RS15135	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
EPB12_RS15140	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EPB12_RS15145	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EPB12_RS15185	COG0438	transferase activity, transferring glycosyl groups
EPB12_RS15215	COG3023	N-Acetylmuramoyl-L-alanine amidase
EPB12_RS15235	COG1596	polysaccharide export
EPB12_RS15255	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EPB12_RS15275	COG0438	transferase activity, transferring glycosyl groups
EPB12_RS15305	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EPB12_RS15310	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
EPB12_RS15320	COG1045	serine acetyltransferase
EPB12_RS15325	COG4942	peptidase
EPB12_RS15345	COG1560	Kdo2-lipid A biosynthetic process
EPB12_RS15365	COG1086	Polysaccharide biosynthesis protein
EPB12_RS15370	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EPB12_RS15375	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
EPB12_RS15380	COG2089	acid synthase
EPB12_RS15395	COG1083	cytidylyl-transferase
EPB12_RS15405	COG0463	Glycosyl transferase, family 2
EPB12_RS15415	COG1519	Transferase
EPB12_RS15420	COG3642	lipopolysaccharide core region biosynthetic process
EPB12_RS15425	COG0859	PFAM glycosyl transferase family 9
EPB12_RS15450	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EPB12_RS15460	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EPB12_RS15465	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EPB12_RS15470	COG2003	Belongs to the UPF0758 family
EPB12_RS15475	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EPB12_RS15480	COG1309	transcriptional regulator
EPB12_RS15485	COG1560	Kdo2-lipid A biosynthetic process
EPB12_RS15490	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EPB12_RS15495	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EPB12_RS15500	COG1561	YicC-like family, N-terminal region
EPB12_RS15505	COG0300	oxidoreductase activity
EPB12_RS15520	COG2252	PERMEase
EPB12_RS15525	COG0194	GDP metabolic process
EPB12_RS15530	COG1758	RNA polymerase activity
EPB12_RS15535	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EPB12_RS15540	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EPB12_RS15555	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EPB12_RS15560	COG2183	response to ionizing radiation
EPB12_RS15570	COG0596	Alpha beta hydrolase
EPB12_RS15580	COG0316	Belongs to the HesB IscA family
EPB12_RS15580	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
EPB12_RS15585	COG0494	nUDIX hydrolase
EPB12_RS15590	COG1218	3'(2'),5'-bisphosphate nucleotidase
EPB12_RS15600	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
EPB12_RS15605	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
EPB12_RS15610	COG3156	type II secretion system protein K
EPB12_RS15615	COG4795	General secretion pathway protein
EPB12_RS15620	COG2165	general secretion pathway protein
EPB12_RS15625	COG2165	general secretion pathway protein
EPB12_RS15630	COG2165	general secretion pathway protein
EPB12_RS15635	COG1459	type II secretion system
EPB12_RS15640	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EPB12_RS15650	COG3031	protein transport across the cell outer membrane
EPB12_RS15655	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EPB12_RS15665	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
EPB12_RS15675	COG0456	acetyltransferase
EPB12_RS15680	COG1490	D-aminoacyl-tRNA deacylase activity
EPB12_RS15685	COG1295	ribonuclease BN
EPB12_RS15700	COG1217	gtp-binding protein TYPA
EPB12_RS15710	COG0174	glutamine synthetase
EPB12_RS15720	COG3852	Histidine kinase
EPB12_RS15735	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EPB12_RS15745	COG3078	GTPase activator activity
EPB12_RS15770	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EPB12_RS15770	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EPB12_RS15785	COG0084	hydrolase, TatD family'
EPB12_RS15790	COG0805	protein transport
EPB12_RS15795	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EPB12_RS15800	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EPB12_RS15805	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EPB12_RS15810	COG3165	ubiquinone biosynthetic process from chorismate
EPB12_RS15815	COG2226	methyltransferase
EPB12_RS15820	COG1322	Protein conserved in bacteria
EPB12_RS15830	COG1910	domain protein
EPB12_RS15850	COG2081	HI0933 family
EPB12_RS15860	COG1528	Iron-storage protein
EPB12_RS15865	COG0589	response to stress
EPB12_RS15880	COG0742	ribosomal rna small subunit methyltransferase
EPB12_RS15885	COG5001	Diguanylate cyclase
EPB12_RS15885	COG5002	protein histidine kinase activity
EPB12_RS15890	COG1522	sequence-specific DNA binding
EPB12_RS15900	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
EPB12_RS15905	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EPB12_RS15990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EPB12_RS15995	COG0601	transmembrane transport
EPB12_RS16045	COG1309	transcriptional regulator
EPB12_RS16050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EPB12_RS16055	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EPB12_RS16060	COG2960	long-chain fatty acid transporting porin activity
EPB12_RS16070	COG0583	DNA-binding transcription factor activity
EPB12_RS16120	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EPB12_RS16130	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EPB12_RS16135	COG0408	coproporphyrinogen oxidase activity
EPB12_RS16140	COG0009	L-threonylcarbamoyladenylate synthase
EPB12_RS16145	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EPB12_RS16150	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EPB12_RS16155	COG0551	DNA topoisomerase type I activity
EPB12_RS16160	COG2922	Belongs to the Smg family
EPB12_RS16165	COG0758	DNA mediated transformation
EPB12_RS16175	COG0242	peptide deformylase activity
EPB12_RS16180	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EPB12_RS16185	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EPB12_RS16185	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EPB12_RS16190	COG0569	domain protein
EPB12_RS16195	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EPB12_RS16205	COG1272	protein, Hemolysin III
EPB12_RS16210	COG4326	sporulation control protein
EPB12_RS16215	COG3084	Protein conserved in bacteria
EPB12_RS16225	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EPB12_RS16230	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EPB12_RS16240	COG0606	chelatase, subunit chli
EPB12_RS16250	COG3978	acetolactate synthase activity
EPB12_RS16255	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EPB12_RS16260	COG0129	dihydroxy-acid dehydratase activity
EPB12_RS16270	COG0583	DNA-binding transcription factor activity
EPB12_RS16275	COG2814	Major facilitator Superfamily
EPB12_RS16280	COG3706	GGDEF domain
EPB12_RS16290	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EPB12_RS16295	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EPB12_RS16300	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EPB12_RS16305	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EPB12_RS16310	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EPB12_RS16315	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EPB12_RS16330	COG3312	ion transport
EPB12_RS16335	COG1475	DNA binding
EPB12_RS16340	COG1192	Involved in chromosome partitioning
EPB12_RS16345	COG0357	Ribosomal RNA small subunit methyltransferase G
EPB12_RS16350	COG0445	tRNA wobble uridine modification
EPB12_RS16360	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EPB12_RS16370	COG0706	membrane insertase activity
EPB12_RS16375	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
EPB12_RS16380	COG0594	ribonuclease P activity
EPB12_RS16385	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EPB12_RS16390	COG1126	abc transporter atp-binding protein
EPB12_RS16420	COG0561	phosphatase activity
EPB12_RS16430	COG0798	PFAM Bile acid sodium symporter
EPB12_RS16435	COG0583	DNA-binding transcription factor activity
EPB12_RS16445	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EPB12_RS16450	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EPB12_RS16455	COG1349	DNA-binding transcription factor activity
EPB12_RS16470	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EPB12_RS16475	COG1028	Short-chain dehydrogenase reductase Sdr
EPB12_RS16480	COG0583	DNA-binding transcription factor activity
EPB12_RS16510	COG1794	racemase activity, acting on amino acids and derivatives
EPB12_RS16525	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EPB12_RS16535	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EPB12_RS16555	COG1301	dicarboxylic acid transport
EPB12_RS16560	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
EPB12_RS16570	COG0110	maltose O-acetyltransferase activity
EPB12_RS16580	COG1609	Transcriptional regulator
EPB12_RS16585	COG2723	6-phospho-beta-galactosidase activity
EPB12_RS16615	COG0346	lactoylglutathione lyase activity
EPB12_RS16630	COG2015	COG2015, Alkyl sulfatase and related hydrolases
EPB12_RS16635	COG0300	oxidoreductase activity
EPB12_RS16645	COG0646	methionine synthase
EPB12_RS16645	COG1410	methionine synthase
EPB12_RS16655	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
EPB12_RS16680	COG0604	alcohol dehydrogenase
EPB12_RS16680	COG1028	Short-chain dehydrogenase reductase Sdr
EPB12_RS16680	COG3321	synthase
EPB12_RS16690	COG2814	Major facilitator Superfamily
EPB12_RS16695	COG2207	Transcriptional regulator
EPB12_RS16710	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EPB12_RS16735	COG2207	Transcriptional regulator
EPB12_RS16740	COG2188	Transcriptional regulator
EPB12_RS16755	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EPB12_RS16760	COG0800	Aldolase
EPB12_RS16765	COG1473	amidohydrolase
EPB12_RS16795	COG2964	Protein conserved in bacteria
EPB12_RS16800	COG0251	oxidation-reduction process
EPB12_RS16805	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EPB12_RS16810	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
EPB12_RS16830	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EPB12_RS16835	COG1072	(Pantothenic acid kinase))
EPB12_RS16840	COG3722	fumarate hydratase activity
EPB12_RS16845	COG1063	alcohol dehydrogenase
EPB12_RS16850	COG2213	PTS system mannitol-specific
EPB12_RS16855	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EPB12_RS16860	COG0456	acetyltransferase
EPB12_RS16870	COG1309	transcriptional regulator
EPB12_RS16875	COG0641	radical SAM
EPB12_RS16905	COG1846	Transcriptional regulator
EPB12_RS16910	COG0517	IMP dehydrogenase activity
EPB12_RS16910	COG4175	Glycine betaine
EPB12_RS16930	COG1012	belongs to the aldehyde dehydrogenase family
EPB12_RS16935	COG1309	transcriptional regulator
EPB12_RS16955	COG3300	MHYT domain
EPB12_RS16955	COG5001	Diguanylate cyclase
EPB12_RS16960	COG0745	RESPONSE REGULATOR receiver
EPB12_RS16965	COG2205	protein histidine kinase activity
EPB12_RS17005	COG0579	oxidoreductase
EPB12_RS17020	COG2204	response regulator
EPB12_RS17035	COG0800	Aldolase
EPB12_RS17040	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EPB12_RS17045	COG4145	pantothenate transmembrane transporter activity
EPB12_RS17055	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
EPB12_RS17085	COG2194	sulfuric ester hydrolase activity
EPB12_RS17100	COG1360	Flagellar Motor Protein
EPB12_RS17105	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EPB12_RS17110	COG1191	sigma factor activity
EPB12_RS17135	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
EPB12_RS17140	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EPB12_RS17200	COG4786	Flagellar basal body rod
EPB12_RS17200	COG1256	bacterial-type flagellum assembly
EPB12_RS17210	COG1706	bacterial-type flagellum-dependent cell motility
EPB12_RS17215	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
EPB12_RS17225	COG4786	Flagellar basal body rod
EPB12_RS17230	COG1749	Flagellar hook protein flgE
EPB12_RS17240	COG1558	bacterial-type flagellum-dependent cell motility
EPB12_RS17245	COG1815	bacterial-type flagellum-dependent cell motility
EPB12_RS17255	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EPB12_RS17265	COG1987	bacterial-type flagellum assembly
EPB12_RS17300	COG1132	(ABC) transporter
EPB12_RS17320	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EPB12_RS17355	COG0259	pyridoxamine-phosphate oxidase activity
EPB12_RS17400	COG1444	tRNA N-acetyltransferase activity
EPB12_RS17430	COG4608	Belongs to the ABC transporter superfamily
EPB12_RS17435	COG0444	Belongs to the ABC transporter superfamily
EPB12_RS17445	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EPB12_RS17445	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
EPB12_RS17485	COG3842	ATPase activity
EPB12_RS17500	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
EPB12_RS17510	COG0625	glutathione transferase activity
EPB12_RS17515	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EPB12_RS17520	COG3186	Phenylalanine-4-hydroxylase
EPB12_RS17535	COG0217	transcriptional regulatory protein
EPB12_RS17550	COG2084	Dehydrogenase
EPB12_RS17570	COG1621	beta-fructofuranosidase activity
EPB12_RS17580	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EPB12_RS17585	COG1072	(Pantothenic acid kinase))
EPB12_RS17600	COG1741	Belongs to the pirin family
EPB12_RS17610	COG0435	Glutathione S-transferase
EPB12_RS17615	COG0778	Nitroreductase
EPB12_RS17630	COG0583	DNA-binding transcription factor activity
EPB12_RS17640	COG1752	Esterase of the alpha-beta hydrolase superfamily
EPB12_RS17645	COG1741	Belongs to the pirin family
EPB12_RS17660	COG4591	ABC-type transport system involved in lipoprotein release permease component
EPB12_RS17675	COG3275	phosphorelay sensor kinase activity
EPB12_RS17680	COG3279	Response regulator of the LytR AlgR family
EPB12_RS17685	COG0612	Peptidase, M16
EPB12_RS17695	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EPB12_RS17700	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EPB12_RS17725	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EPB12_RS17735	COG1401	restriction endodeoxyribonuclease activity
EPB12_RS17745	COG1902	pentaerythritol trinitrate reductase activity
EPB12_RS17750	COG2814	Major facilitator Superfamily
EPB12_RS17755	COG1028	Short-chain dehydrogenase reductase Sdr
EPB12_RS17760	COG0583	DNA-binding transcription factor activity
EPB12_RS17775	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EPB12_RS17780	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EPB12_RS17785	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EPB12_RS17810	COG1609	Transcriptional regulator
EPB12_RS17815	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EPB12_RS17840	COG2084	Dehydrogenase
EPB12_RS17855	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EPB12_RS17860	COG0667	Aldo Keto reductase
EPB12_RS17875	COG0583	DNA-binding transcription factor activity
EPB12_RS17880	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EPB12_RS17895	COG0679	Auxin Efflux Carrier
EPB12_RS17905	COG1082	Xylose isomerase domain protein TIM barrel
EPB12_RS17905	COG3185	4-Hydroxyphenylpyruvate dioxygenase
EPB12_RS17910	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
EPB12_RS17945	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EPB12_RS17970	COG0415	Belongs to the DNA photolyase family
EPB12_RS17980	COG3806	Anti-sigma factor
EPB12_RS17985	COG1595	DNA-templated transcription, initiation
EPB12_RS17995	COG1942	4-Oxalocrotonate Tautomerase
EPB12_RS18010	COG0786	glutamate:sodium symporter activity
EPB12_RS18015	COG0446	pyridine nucleotide-disulphide oxidoreductase
EPB12_RS18035	COG2213	PTS system mannitol-specific
EPB12_RS18035	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
EPB12_RS18040	COG0246	Mannitol dehydrogenase
EPB12_RS18045	COG3722	fumarate hydratase activity
EPB12_RS18050	COG0363	glucosamine-6-phosphate deaminase activity
EPB12_RS18070	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
EPB12_RS18075	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EPB12_RS18090	COG3366	ferrous iron transmembrane transporter activity
EPB12_RS18095	COG0700	Nucleoside recognition
EPB12_RS18100	COG3788	relative of glutathione S-transferase, MAPEG superfamily
EPB12_RS18145	COG0596	Alpha beta hydrolase
EPB12_RS18160	COG3123	guanosine phosphorylase activity
EPB12_RS18165	COG1741	Belongs to the pirin family
EPB12_RS18200	COG0745	RESPONSE REGULATOR receiver
EPB12_RS18215	COG1054	Belongs to the UPF0176 family
EPB12_RS18220	COG2015	COG2015, Alkyl sulfatase and related hydrolases
EPB12_RS18225	COG0583	DNA-binding transcription factor activity
EPB12_RS18235	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EPB12_RS18240	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EPB12_RS18240	COG2207	Transcriptional regulator
EPB12_RS18260	COG1304	FMN binding
EPB12_RS18265	COG1620	l-lactate permease
EPB12_RS18270	COG0583	DNA-binding transcription factor activity
EPB12_RS18275	COG1505	serine-type exopeptidase activity
EPB12_RS18295	COG1609	Transcriptional regulator
EPB12_RS18310	COG0395	ABC-type sugar transport system, permease component
EPB12_RS18315	COG2723	6-phospho-beta-galactosidase activity
EPB12_RS18320	COG3842	ATPase activity
EPB12_RS18325	COG3459	Glycosyltransferase 36 associated
EPB12_RS18330	COG2017	converts alpha-aldose to the beta-anomer
EPB12_RS18340	COG1609	Transcriptional regulator
EPB12_RS18345	COG4172	Belongs to the ABC transporter superfamily
EPB12_RS18355	COG1067	ATP-dependent peptidase activity
EPB12_RS18445	COG4964	Belongs to the GSP D family
EPB12_RS18470	COG2814	Major facilitator Superfamily
EPB12_RS18510	COG1846	Transcriptional regulator
EPB12_RS18525	COG0583	DNA-binding transcription factor activity
EPB12_RS18530	COG2259	Doxx family
EPB12_RS18540	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EPB12_RS18545	COG3960	tartronate-semialdehyde synthase activity
EPB12_RS18550	COG3622	Belongs to the hyi family
EPB12_RS18555	COG2084	Dehydrogenase
EPB12_RS18570	COG0402	S-adenosylhomocysteine deaminase activity
EPB12_RS18595	COG2252	PERMEase
EPB12_RS18615	COG4266	Belongs to the allantoicase family
EPB12_RS18620	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
EPB12_RS18630	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EPB12_RS18630	COG2755	lipolytic protein G-D-S-L family
EPB12_RS18640	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EPB12_RS18680	COG1228	amidohydrolase
EPB12_RS18705	COG0402	S-adenosylhomocysteine deaminase activity
EPB12_RS18715	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EPB12_RS18725	COG2186	Transcriptional regulator
EPB12_RS18740	COG1418	mRNA catabolic process
EPB12_RS18745	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EPB12_RS18750	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EPB12_RS18775	COG0277	FAD linked oxidase domain protein
EPB12_RS18800	COG3655	Transcriptional regulator
EPB12_RS18805	COG0625	glutathione transferase activity
EPB12_RS18810	COG0583	DNA-binding transcription factor activity
EPB12_RS18815	COG0840	transmembrane signaling receptor activity
EPB12_RS18820	COG0415	Belongs to the DNA photolyase family
EPB12_RS18825	COG3284	Transcriptional regulator
EPB12_RS18845	COG1288	antiporter activity
EPB12_RS18870	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
EPB12_RS18900	COG0625	glutathione transferase activity
EPB12_RS18925	COG4166	transmembrane transport
EPB12_RS18930	COG0583	DNA-binding transcription factor activity
EPB12_RS18955	COG0546	phosphoglycolate phosphatase activity
EPB12_RS18960	COG3842	ATPase activity
EPB12_RS18965	COG0765	amino acid transport
EPB12_RS18975	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EPB12_RS18990	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EPB12_RS18990	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EPB12_RS18990	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EPB12_RS18995	COG2207	Transcriptional regulator
EPB12_RS19005	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EPB12_RS19010	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EPB12_RS19020	COG0840	transmembrane signaling receptor activity
EPB12_RS19025	COG0814	amino acid
EPB12_RS19030	COG2814	Major facilitator Superfamily
EPB12_RS19055	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EPB12_RS19060	COG0697	spore germination
EPB12_RS19075	COG0583	DNA-binding transcription factor activity
EPB12_RS19100	COG0583	DNA-binding transcription factor activity
EPB12_RS19110	COG4948	Mandelate Racemase Muconate Lactonizing
EPB12_RS19130	COG1288	antiporter activity
EPB12_RS19135	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EPB12_RS19140	COG3047	cAMP biosynthetic process
EPB12_RS19150	COG4221	oxidoreductase activity
EPB12_RS19155	COG0583	DNA-binding transcription factor activity
EPB12_RS19160	COG1733	regulation of RNA biosynthetic process
EPB12_RS19165	COG1028	Short-chain dehydrogenase reductase Sdr
EPB12_RS19180	COG0583	DNA-binding transcription factor activity
EPB12_RS19190	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EPB12_RS19215	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EPB12_RS19245	COG1901	pseudouridine methyltransferase
EPB12_RS19290	COG0446	pyridine nucleotide-disulphide oxidoreductase
EPB12_RS19305	COG2964	Protein conserved in bacteria
EPB12_RS19310	COG0534	Mate efflux family protein
EPB12_RS19320	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EPB12_RS19320	COG0574	Belongs to the PEP-utilizing enzyme family
EPB12_RS19325	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
EPB12_RS19330	COG2999	glutathione oxidoreductase activity
EPB12_RS19335	COG0673	inositol 2-dehydrogenase activity
EPB12_RS19355	COG0584	glycerophosphoryl diester phosphodiesterase
EPB12_RS19370	COG4067	protein conserved in archaea
EPB12_RS19370	COG0189	ligase activity
EPB12_RS19375	COG0189	ligase activity
EPB12_RS19380	COG4533	DNA binding
EPB12_RS19440	COG0564	pseudouridine synthase activity
EPB12_RS19445	COG2816	NAD+ diphosphatase activity
EPB12_RS19450	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EPB12_RS19450	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EPB12_RS19470	COG1131	(ABC) transporter
EPB12_RS19475	COG2186	Transcriptional regulator
EPB12_RS19490	COG2200	EAL domain
EPB12_RS19500	COG5001	Diguanylate cyclase
EPB12_RS19510	COG0745	RESPONSE REGULATOR receiver
EPB12_RS19515	COG2205	protein histidine kinase activity
EPB12_RS19520	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EPB12_RS19525	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
EPB12_RS19535	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EPB12_RS19540	COG3037	sugar-specific permease SgaT UlaA
EPB12_RS19560	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EPB12_RS19570	COG4106	trans-aconitate 2-methyltransferase activity
EPB12_RS19585	COG0513	Belongs to the DEAD box helicase family
EPB12_RS19600	COG3706	GGDEF domain
EPB12_RS19605	COG1278	Cold shock
EPB12_RS19610	COG0402	S-adenosylhomocysteine deaminase activity
EPB12_RS19615	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
EPB12_RS19635	COG4413	Urea transporter
EPB12_RS19650	COG0531	amino acid
EPB12_RS19655	COG1522	sequence-specific DNA binding
EPB12_RS19665	COG1280	lysine exporter protein (LysE YggA)
EPB12_RS19680	COG1151	hydroxylamine reductase activity
EPB12_RS19685	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EPB12_RS19695	COG5002	protein histidine kinase activity
EPB12_RS19695	COG2205	protein histidine kinase activity
EPB12_RS19695	COG0784	Response regulator, receiver
EPB12_RS19710	COG2926	Belongs to the UPF0265 family
EPB12_RS19720	COG3132	Protein of unknown function, DUF480
EPB12_RS19725	COG2827	Endonuclease containing a URI domain
EPB12_RS19765	COG0179	Fumarylacetoacetate (FAA) hydrolase
EPB12_RS19770	COG1280	lysine exporter protein (LysE YggA)
EPB12_RS19775	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EPB12_RS19780	COG1565	acr, cog1565
EPB12_RS19780	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EPB12_RS19795	COG1845	cytochrome c oxidase, subunit III
EPB12_RS19815	COG1612	heme a metabolic process
EPB12_RS19820	COG0109	protoheme IX farnesyltransferase activity
EPB12_RS19840	COG3530	Putative quorum-sensing-regulated virulence factor
EPB12_RS19845	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EPB12_RS19855	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EPB12_RS19860	COG0662	Cupin 2, conserved barrel domain protein
EPB12_RS19860	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
EPB12_RS19870	COG0668	transmembrane transport
EPB12_RS19880	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
EPB12_RS19915	COG0668	transmembrane transport
EPB12_RS19920	COG0569	domain protein
EPB12_RS19925	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EPB12_RS19930	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EPB12_RS19930	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EPB12_RS19935	COG1765	OsmC-like protein
EPB12_RS19940	COG2885	chlorophyll binding
EPB12_RS19950	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EPB12_RS19960	COG1840	ABC-type Fe3 transport system, periplasmic component
EPB12_RS19970	COG3842	ATPase activity
EPB12_RS19980	COG2188	Transcriptional regulator
EPB12_RS19990	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EPB12_RS20000	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EPB12_RS20005	COG3265	gluconokinase activity
EPB12_RS20010	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
EPB12_RS20015	COG1609	Transcriptional regulator
EPB12_RS20020	COG2375	cellular response to nickel ion
EPB12_RS20025	COG3104	oligopeptide transport
EPB12_RS20030	COG1760	l-serine dehydratase
EPB12_RS20050	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EPB12_RS20070	COG1132	(ABC) transporter
EPB12_RS20075	COG1132	(ABC) transporter
EPB12_RS20080	COG0583	DNA-binding transcription factor activity
EPB12_RS20085	COG3119	arylsulfatase activity
EPB12_RS20110	COG0739	heme binding
EPB12_RS20115	COG0393	Putative heavy-metal-binding
EPB12_RS20130	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
EPB12_RS20135	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EPB12_RS20155	COG0346	lactoylglutathione lyase activity
EPB12_RS20165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EPB12_RS20180	COG0577	efflux transmembrane transporter activity
EPB12_RS20180	COG1136	(ABC) transporter
EPB12_RS20185	COG1136	(ABC) transporter
EPB12_RS20185	COG0577	efflux transmembrane transporter activity
EPB12_RS20200	COG2200	EAL domain
EPB12_RS20205	COG0156	8-amino-7-oxononanoate synthase activity
EPB12_RS20210	COG1063	alcohol dehydrogenase
EPB12_RS20230	COG1002	Type II restriction enzyme, methylase subunits
EPB12_RS20235	COG1061	Type III restriction enzyme res subunit
EPB12_RS20240	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EPB12_RS20245	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EPB12_RS20275	COG2249	NAD(P)H dehydrogenase (quinone) activity
EPB12_RS20295	COG1454	alcohol dehydrogenase
EPB12_RS20300	COG1011	Hydrolase
EPB12_RS20325	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EPB12_RS20330	COG1328	CTP reductase activity
EPB12_RS20335	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EPB12_RS20340	COG0583	DNA-binding transcription factor activity
EPB12_RS20365	COG0210	DNA helicase
EPB12_RS20380	COG2801	Transposase and inactivated derivatives
EPB12_RS20385	COG1803	Methylglyoxal synthase
EPB12_RS20390	COG1879	ABC-type sugar transport system periplasmic component
EPB12_RS20395	COG2198	Histidine kinase
EPB12_RS20395	COG2205	protein histidine kinase activity
EPB12_RS20395	COG0784	Response regulator, receiver
EPB12_RS20425	COG0625	glutathione transferase activity
EPB12_RS20430	COG1252	NADH dehydrogenase
EPB12_RS20445	COG0745	RESPONSE REGULATOR receiver
EPB12_RS20480	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
EPB12_RS20480	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EPB12_RS20480	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EPB12_RS20485	COG1105	Belongs to the carbohydrate kinase PfkB family
EPB12_RS20490	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
EPB12_RS20490	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EPB12_RS20495	COG1609	Transcriptional regulator
EPB12_RS20515	COG0515	serine threonine protein kinase
EPB12_RS20515	COG2815	serine threonine protein kinase
EPB12_RS20520	COG2223	nitrite transmembrane transporter activity
EPB12_RS20530	COG2146	nitrite reductase [NAD(P)H] activity
EPB12_RS20530	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EPB12_RS20595	COG0494	nUDIX hydrolase
EPB12_RS20600	COG0242	peptide deformylase activity
EPB12_RS20620	COG3547	Transposase (IS116 IS110 IS902 family)
EPB12_RS20625	COG0232	Belongs to the dGTPase family. Type 2 subfamily
EPB12_RS20645	COG0789	Transcriptional regulator
EPB12_RS20650	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EPB12_RS20665	COG4943	cyclic-guanylate-specific phosphodiesterase activity
EPB12_RS20685	COG1609	Transcriptional regulator
EPB12_RS20690	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EPB12_RS20695	COG1879	ABC-type sugar transport system periplasmic component
EPB12_RS20700	COG1172	Belongs to the binding-protein-dependent transport system permease family
EPB12_RS20705	COG1129	ABC transporter
EPB12_RS20710	COG1869	D-ribose catabolic process
EPB12_RS20740	COG4166	transmembrane transport
EPB12_RS20745	COG4174	ABC transporter (Permease)
EPB12_RS20750	COG4239	(ABC) transporter, permease
EPB12_RS20755	COG4172	Belongs to the ABC transporter superfamily
EPB12_RS20765	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EPB12_RS20780	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EPB12_RS20780	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
EPB12_RS20790	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EPB12_RS20795	COG1609	Transcriptional regulator
EPB12_RS20805	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EPB12_RS20825	COG0583	DNA-binding transcription factor activity
EPB12_RS20830	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EPB12_RS20835	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EPB12_RS20845	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EPB12_RS20855	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EPB12_RS20870	COG0356	it plays a direct role in the translocation of protons across the membrane
EPB12_RS20880	COG0583	DNA-binding transcription factor activity
EPB12_RS20890	COG1012	belongs to the aldehyde dehydrogenase family
EPB12_RS20900	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EPB12_RS20940	COG3278	Belongs to the heme-copper respiratory oxidase family
EPB12_RS20960	COG3300	MHYT domain
EPB12_RS20960	COG5001	Diguanylate cyclase
EPB12_RS20970	COG0384	phenazine biosynthesis protein PhzF
EPB12_RS21005	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
EPB12_RS21015	COG0456	acetyltransferase
EPB12_RS21030	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
EPB12_RS21040	COG2205	protein histidine kinase activity
EPB12_RS21040	COG0784	Response regulator, receiver
EPB12_RS21050	COG3119	arylsulfatase activity
EPB12_RS21055	COG3119	arylsulfatase activity
EPB12_RS21065	COG0714	Associated with various cellular activities
EPB12_RS21095	COG0583	DNA-binding transcription factor activity
EPB12_RS21100	COG3300	MHYT domain
EPB12_RS21100	COG5001	Diguanylate cyclase
EPB12_RS21125	COG0641	radical SAM
EPB12_RS21135	COG0405	Gamma-glutamyltransferase
EPB12_RS21140	COG0840	transmembrane signaling receptor activity
EPB12_RS21165	COG0784	Response regulator, receiver
EPB12_RS21165	COG5002	protein histidine kinase activity
EPB12_RS21165	COG2205	protein histidine kinase activity
EPB12_RS21185	COG1538	Outer membrane efflux protein
EPB12_RS21195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EPB12_RS21260	COG5002	protein histidine kinase activity
EPB12_RS21265	COG1881	PFAM PEBP family protein
EPB12_RS21310	COG1280	lysine exporter protein (LysE YggA)
EPB12_RS21320	COG0534	Mate efflux family protein
EPB12_RS21345	COG0509	glycine decarboxylation via glycine cleavage system
EPB12_RS21385	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EPB12_RS21415	COG0784	Response regulator, receiver
EPB12_RS21415	COG3437	response regulator, receiver
EPB12_RS21420	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EPB12_RS21430	COG0840	transmembrane signaling receptor activity
EPB12_RS21435	COG0814	amino acid
EPB12_RS21440	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
EPB12_RS21445	COG0513	Belongs to the DEAD box helicase family
EPB12_RS21455	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EPB12_RS21460	COG1566	PFAM secretion protein HlyD family protein
EPB12_RS21470	COG2200	EAL domain
EPB12_RS21485	COG3038	cytochrome b561
EPB12_RS21490	COG2353	YceI-like domain
EPB12_RS21495	COG2116	formate transmembrane transporter activity
EPB12_RS21500	COG0583	DNA-binding transcription factor activity
EPB12_RS21510	COG3593	DNA synthesis involved in DNA repair
EPB12_RS21515	COG0737	Belongs to the 5'-nucleotidase family
EPB12_RS21520	COG0861	Integral membrane protein TerC family
EPB12_RS21535	COG0513	Belongs to the DEAD box helicase family
EPB12_RS21545	COG1566	PFAM secretion protein HlyD family protein
EPB12_RS21555	COG0583	DNA-binding transcription factor activity
EPB12_RS21570	COG2067	long-chain fatty acid transport protein
EPB12_RS21580	COG0501	Belongs to the peptidase M48B family
EPB12_RS21585	COG2050	protein possibly involved in aromatic compounds catabolism
EPB12_RS21595	COG4533	DNA binding
EPB12_RS21625	COG0768	penicillin binding
EPB12_RS21635	COG1716	ATPase activity
EPB12_RS21635	COG5001	Diguanylate cyclase
EPB12_RS21640	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EPB12_RS21650	COG4181	ATPase activity
EPB12_RS21670	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
EPB12_RS21690	COG3447	MASE1 domain protein
EPB12_RS21690	COG5002	protein histidine kinase activity
EPB12_RS21690	COG5001	Diguanylate cyclase
EPB12_RS21700	COG1629	transport
EPB12_RS21700	COG4771	TonB-dependent receptor
EPB12_RS21705	COG0583	DNA-binding transcription factor activity
EPB12_RS21710	COG0045	succinate-CoA ligase (ADP-forming) activity
EPB12_RS21710	COG1042	CoA-binding domain protein
EPB12_RS21710	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EPB12_RS21715	COG3266	domain, Protein
EPB12_RS21720	COG1181	Belongs to the D-alanine--D-alanine ligase family
EPB12_RS21735	COG0023	Translation Initiation Factor
EPB12_RS21805	COG3706	GGDEF domain
EPB12_RS21810	COG3140	Belongs to the UPF0181 family
EPB12_RS21830	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
EPB12_RS21835	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
EPB12_RS21850	COG3706	GGDEF domain
EPB12_RS21860	COG2203	Gaf domain
EPB12_RS21860	COG4251	negative regulation of phosphorylation
EPB12_RS21860	COG5001	Diguanylate cyclase
EPB12_RS21860	COG3706	GGDEF domain
EPB12_RS21870	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
EPB12_RS21875	COG4149	molybdate abc transporter
EPB12_RS21880	COG0725	ABC transporter, periplasmic molybdate-binding protein
EPB12_RS21905	COG0488	(ABC) transporter
EPB12_RS21910	COG4067	protein conserved in archaea
EPB12_RS21910	COG0189	ligase activity
EPB12_RS21925	COG0534	Mate efflux family protein
EPB12_RS21930	COG0602	queuosine metabolic process
EPB12_RS21935	COG1328	CTP reductase activity
EPB12_RS21970	COG3118	belongs to the thioredoxin family
EPB12_RS21980	COG0318	PFAM AMP-dependent synthetase and ligase
EPB12_RS22015	COG0534	Mate efflux family protein
EPB12_RS22040	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EPB12_RS22040	COG1321	iron dependent repressor
EPB12_RS22045	COG1121	(ABC) transporter
EPB12_RS22050	COG0803	Belongs to the bacterial solute-binding protein 9 family
EPB12_RS22095	COG0848	biopolymer transport protein
EPB12_RS22100	COG0811	peptide transport
EPB12_RS22105	COG0811	peptide transport
EPB12_RS22120	COG1301	dicarboxylic acid transport
EPB12_RS22130	COG0745	RESPONSE REGULATOR receiver
EPB12_RS22145	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EPB12_RS22145	COG1648	precorrin-2 dehydrogenase activity
EPB12_RS22150	COG2116	formate transmembrane transporter activity
EPB12_RS22160	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EPB12_RS22200	COG0840	transmembrane signaling receptor activity
EPB12_RS22225	COG2425	protein containing a von Willebrand factor type A (vWA) domain
EPB12_RS22235	COG0494	nUDIX hydrolase
EPB12_RS22240	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
EPB12_RS22250	COG0582	viral genome integration into host DNA
EPB12_RS22260	COG2977	Belongs to the P-Pant transferase superfamily
EPB12_RS22310	COG0076	glutamate decarboxylase activity
EPB12_RS22315	COG0076	glutamate decarboxylase activity
EPB12_RS22320	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EPB12_RS22335	COG2226	methyltransferase
EPB12_RS22335	COG3433	isochorismatase activity
EPB12_RS22335	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EPB12_RS22345	COG3321	synthase
EPB12_RS22345	COG1028	Short-chain dehydrogenase reductase Sdr
EPB12_RS22345	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EPB12_RS22345	COG0318	PFAM AMP-dependent synthetase and ligase
EPB12_RS22345	COG0300	oxidoreductase activity
EPB12_RS22350	COG3321	synthase
EPB12_RS22350	COG1028	Short-chain dehydrogenase reductase Sdr
EPB12_RS22350	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EPB12_RS22350	COG0318	PFAM AMP-dependent synthetase and ligase
EPB12_RS22350	COG0300	oxidoreductase activity
EPB12_RS22360	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
EPB12_RS22360	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EPB12_RS22370	COG0534	Mate efflux family protein
EPB12_RS22385	COG1132	(ABC) transporter
EPB12_RS22390	COG2375	cellular response to nickel ion
EPB12_RS22390	COG1132	(ABC) transporter
EPB12_RS22405	COG3328	transposase activity
EPB12_RS22415	COG0328	RNA-DNA hybrid ribonuclease activity
EPB12_RS22420	COG2003	Belongs to the UPF0758 family
EPB12_RS22470	COG3706	GGDEF domain
EPB12_RS22505	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EPB12_RS22510	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EPB12_RS22515	COG2067	long-chain fatty acid transport protein
EPB12_RS22535	COG3069	C4-dicarboxylate transmembrane transporter activity
EPB12_RS22540	COG2197	response regulator
EPB12_RS22545	COG3850	Histidine kinase
EPB12_RS22560	COG0243	molybdopterin cofactor binding
EPB12_RS22580	COG3243	poly(R)-hydroxyalkanoic acid synthase
EPB12_RS22590	COG0183	Belongs to the thiolase family
EPB12_RS22635	COG0745	RESPONSE REGULATOR receiver
EPB12_RS22660	COG1280	lysine exporter protein (LysE YggA)
EPB12_RS22665	COG0513	Belongs to the DEAD box helicase family
EPB12_RS22670	COG0523	cobalamin synthesis protein
EPB12_RS22675	COG0038	chloride channel
EPB12_RS22685	COG1017	nitric oxide dioxygenase activity
EPB12_RS22685	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EPB12_RS22725	COG1309	transcriptional regulator
EPB12_RS22740	COG0564	pseudouridine synthase activity
EPB12_RS22750	COG1686	Belongs to the peptidase S11 family
EPB12_RS22775	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EPB12_RS22795	COG3059	membrane
EPB12_RS22840	COG2207	Transcriptional regulator
EPB12_RS22845	COG1979	alcohol dehydrogenase
EPB12_RS22850	COG1126	abc transporter atp-binding protein
EPB12_RS22855	COG0765	amino acid transport
EPB12_RS22865	COG0765	amino acid transport
EPB12_RS22880	COG3708	Transcriptional regulator
EPB12_RS22880	COG2207	Transcriptional regulator
EPB12_RS22890	COG1280	lysine exporter protein (LysE YggA)
EPB12_RS22925	COG2824	Alkylphosphonate utilization operon protein PhnA
EPB12_RS22955	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EPB12_RS22995	COG1132	(ABC) transporter
EPB12_RS23010	COG1902	pentaerythritol trinitrate reductase activity
EPB12_RS23010	COG0446	pyridine nucleotide-disulphide oxidoreductase
EPB12_RS23020	COG3710	Transcriptional regulator
EPB12_RS23035	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EPB12_RS23040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EPB12_RS23050	COG2985	domain, Protein
EPB12_RS23100	COG1120	ATPase activity
EPB12_RS23110	COG2133	pyrroloquinoline quinone binding
EPB12_RS23120	COG1278	Cold shock
EPB12_RS23155	COG4681	YaeQ
EPB12_RS23165	COG0302	gtp cyclohydrolase
EPB12_RS23215	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EPB12_RS23225	COG0840	transmembrane signaling receptor activity
EPB12_RS23230	COG1522	sequence-specific DNA binding
EPB12_RS23250	COG2814	Major facilitator Superfamily
EPB12_RS23255	COG0583	DNA-binding transcription factor activity
EPB12_RS23260	COG0784	Response regulator, receiver
EPB12_RS23260	COG2205	protein histidine kinase activity
EPB12_RS23265	COG3437	response regulator, receiver
EPB12_RS23270	COG4604	ABC transporter, ATP-binding protein
EPB12_RS23275	COG4605	iron ion homeostasis
EPB12_RS23280	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EPB12_RS23285	COG4607	ABC-type enterochelin transport system periplasmic component
EPB12_RS23310	COG0628	permease
EPB12_RS23320	COG1566	PFAM secretion protein HlyD family protein
EPB12_RS23330	COG3706	GGDEF domain
EPB12_RS23360	COG0583	DNA-binding transcription factor activity
EPB12_RS23380	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
EPB12_RS23385	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EPB12_RS23390	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EPB12_RS23400	COG1116	anion transmembrane transporter activity
EPB12_RS23405	COG0351	phosphomethylpyrimidine kinase
EPB12_RS23485	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EPB12_RS23495	COG1196	nuclear chromosome segregation
EPB12_RS23500	COG0732	type I restriction modification DNA specificity domain
EPB12_RS23505	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
EPB12_RS23565	COG0516	GMP reductase activity
EPB12_RS23595	COG0534	Mate efflux family protein
EPB12_RS23600	COG0583	DNA-binding transcription factor activity
EPB12_RS23605	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EPB12_RS23610	COG0366	Alpha amylase catalytic
EPB12_RS23675	COG1396	sequence-specific DNA binding
EPB12_RS23725	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EPB12_RS23730	COG0513	Belongs to the DEAD box helicase family
EPB12_RS23735	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
EPB12_RS23750	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EPB12_RS23785	COG2195	Cleaves the N-terminal amino acid of tripeptides
EPB12_RS23790	COG0667	Aldo Keto reductase
EPB12_RS23795	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EPB12_RS23800	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
EPB12_RS23805	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
EPB12_RS23810	COG0778	Nitroreductase
EPB12_RS23815	COG0513	Belongs to the DEAD box helicase family
EPB12_RS23825	COG2176	DNA-directed DNA polymerase activity
EPB12_RS23840	COG0513	Belongs to the DEAD box helicase family
EPB12_RS23845	COG4989	oxidoreductase activity
EPB12_RS23865	COG1538	Outer membrane efflux protein
EPB12_RS23870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EPB12_RS23905	COG2197	response regulator
EPB12_RS23915	COG0668	transmembrane transport
EPB12_RS23925	COG4232	protein-disulfide reductase activity
EPB12_RS23930	COG3118	belongs to the thioredoxin family
EPB12_RS23945	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EPB12_RS23965	COG2814	Major facilitator Superfamily
EPB12_RS23975	COG5001	Diguanylate cyclase
EPB12_RS23980	COG0739	heme binding
EPB12_RS24005	COG3314	Sporulation integral membrane protein YlbJ
EPB12_RS24015	COG0366	Alpha amylase catalytic
EPB12_RS24025	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EPB12_RS24030	COG0835	chemotaxis
EPB12_RS24030	COG0784	Response regulator, receiver
EPB12_RS24035	COG2096	Adenosyltransferase
EPB12_RS24040	COG0748	coenzyme F420 binding
EPB12_RS24045	COG3721	Heme iron utilization protein
EPB12_RS24055	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
EPB12_RS24060	COG0811	peptide transport
EPB12_RS24065	COG0848	biopolymer transport protein
EPB12_RS24075	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EPB12_RS24080	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
EPB12_RS24125	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EPB12_RS24130	COG0633	Ferredoxin
EPB12_RS24130	COG3217	Mosc domain protein beta barrel domain protein
EPB12_RS24140	COG0418	dihydroorotase activity
EPB12_RS24145	COG2354	Protein conserved in bacteria
EPB12_RS24155	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EPB12_RS24170	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EPB12_RS24170	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
EPB12_RS24175	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
EPB12_RS24180	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EPB12_RS24185	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EPB12_RS24215	COG0730	response to heat
EPB12_RS24225	COG1414	Transcriptional regulator
EPB12_RS24230	COG1012	belongs to the aldehyde dehydrogenase family
EPB12_RS24260	COG4934	collagen metabolic process
EPB12_RS24300	COG0583	DNA-binding transcription factor activity
EPB12_RS24310	COG1566	PFAM secretion protein HlyD family protein
EPB12_RS24330	COG0577	efflux transmembrane transporter activity
EPB12_RS24365	COG2356	endonuclease I
EPB12_RS24395	COG4166	transmembrane transport
EPB12_RS24410	COG3833	ABC-type maltose transport systems, permease component
EPB12_RS24415	COG1175	transmembrane transport
EPB12_RS24425	COG3842	ATPase activity
EPB12_RS24435	COG0840	transmembrane signaling receptor activity
EPB12_RS24440	COG0714	Associated with various cellular activities
EPB12_RS24455	COG2304	oxidoreductase activity
EPB12_RS24460	COG2304	oxidoreductase activity
EPB12_RS24475	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EPB12_RS24480	COG0581	inorganic phosphate transmembrane transporter activity
EPB12_RS24485	COG0573	inorganic phosphate transmembrane transporter activity
EPB12_RS24495	COG0840	transmembrane signaling receptor activity
EPB12_RS24515	COG4771	TonB-dependent receptor
EPB12_RS24520	COG1770	oligopeptidase
EPB12_RS24530	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
EPB12_RS24535	COG3240	lipase activity
EPB12_RS24540	COG0513	Belongs to the DEAD box helicase family
EPB12_RS24550	COG1376	ErfK ybiS ycfS ynhG family protein
EPB12_RS24550	COG1388	LysM domain
EPB12_RS24555	COG0813	purine-nucleoside phosphorylase activity
EPB12_RS24585	COG1566	PFAM secretion protein HlyD family protein
EPB12_RS24590	COG4720	Psort location CytoplasmicMembrane, score
EPB12_RS24595	COG1122	ATPase activity
EPB12_RS24615	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EPB12_RS24620	COG1640	4-alpha-glucanotransferase
EPB12_RS24625	COG0058	SHG alpha-glucan phosphorylase activity
EPB12_RS24630	COG2909	trisaccharide binding
EPB12_RS24645	COG1999	signal sequence binding
EPB12_RS24655	COG1162	GTPase activity
EPB12_RS24660	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
EPB12_RS24700	COG3258	Cytochrome c
EPB12_RS24725	COG0366	Alpha amylase catalytic
EPB12_RS24740	COG4580	involved in the transport of maltose and maltodextrins
EPB12_RS24755	COG2384	SAM-dependent methyltransferase
EPB12_RS24760	COG0204	Acyl-transferase
EPB12_RS24765	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EPB12_RS24775	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EPB12_RS24780	COG4667	esterase of the alpha-beta hydrolase superfamily
EPB12_RS24785	COG0753	catalase activity
EPB12_RS24790	COG1929	Belongs to the glycerate kinase type-1 family
EPB12_RS24805	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
EPB12_RS24810	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EPB12_RS24815	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EPB12_RS24840	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
EPB12_RS24845	COG1414	Transcriptional regulator
EPB12_RS24850	COG3623	hexulose-6-phosphate isomerase
EPB12_RS24865	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EPB12_RS24870	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EPB12_RS24880	COG3623	hexulose-6-phosphate isomerase
EPB12_RS24885	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
EPB12_RS24890	COG0561	phosphatase activity
EPB12_RS24950	COG0583	DNA-binding transcription factor activity