locus-tag	class	description
VAA049_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
VAA049_RS00010	COG0592	DNA-directed DNA polymerase activity
VAA049_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
VAA049_RS00020	COG0187	DNA topoisomerase II activity
VAA049_RS00035	COG0071	Belongs to the small heat shock protein (HSP20) family
VAA049_RS00040	COG3977	Valine--pyruvate aminotransferase
VAA049_RS00045	COG0751	glycine-tRNA ligase activity
VAA049_RS00050	COG0752	glycyl-tRNA synthetase alpha subunit
VAA049_RS00055	COG2119	membrane
VAA049_RS00065	COG0425	Belongs to the sulfur carrier protein TusA family
VAA049_RS00075	COG0604	alcohol dehydrogenase
VAA049_RS00090	COG0129	dihydroxy-acid dehydratase activity
VAA049_RS00095	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VAA049_RS00110	COG0606	chelatase, subunit chli
VAA049_RS00115	COG0204	Acyl-transferase
VAA049_RS00120	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VAA049_RS00125	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
VAA049_RS00135	COG3084	Protein conserved in bacteria
VAA049_RS00145	COG4326	sporulation control protein
VAA049_RS00150	COG1272	protein, Hemolysin III
VAA049_RS00160	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VAA049_RS00165	COG0569	domain protein
VAA049_RS00170	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VAA049_RS00170	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VAA049_RS00175	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
VAA049_RS00180	COG0242	peptide deformylase activity
VAA049_RS00185	COG1652	LysM domain
VAA049_RS00190	COG0758	DNA mediated transformation
VAA049_RS00195	COG2922	Belongs to the Smg family
VAA049_RS00200	COG0551	DNA topoisomerase type I activity
VAA049_RS00205	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
VAA049_RS00210	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
VAA049_RS00215	COG0009	L-threonylcarbamoyladenylate synthase
VAA049_RS00220	COG0408	coproporphyrinogen oxidase activity
VAA049_RS00225	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
VAA049_RS00235	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
VAA049_RS00275	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
VAA049_RS00280	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
VAA049_RS00290	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VAA049_RS00295	COG2104	thiamine diphosphate biosynthetic process
VAA049_RS00300	COG2022	thiamine diphosphate biosynthetic process
VAA049_RS00305	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
VAA049_RS00310	COG0006	proline dipeptidase activity
VAA049_RS00310	COG0006	proline dipeptidase activity
VAA049_RS00330	COG1522	sequence-specific DNA binding
VAA049_RS00335	COG5002	protein histidine kinase activity
VAA049_RS00335	COG5001	Diguanylate cyclase
VAA049_RS00355	COG0589	response to stress
VAA049_RS00365	COG1528	Iron-storage protein
VAA049_RS00375	COG2081	HI0933 family
VAA049_RS00385	COG1322	Protein conserved in bacteria
VAA049_RS00390	COG2226	methyltransferase
VAA049_RS00405	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VAA049_RS00410	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VAA049_RS00415	COG0805	protein transport
VAA049_RS00420	COG1858	cytochrome C peroxidase
VAA049_RS00425	COG0534	Mate efflux family protein
VAA049_RS00435	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
VAA049_RS00440	COG2937	Belongs to the GPAT DAPAT family
VAA049_RS00445	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
VAA049_RS00450	COG3161	chorismate lyase activity
VAA049_RS00460	COG1580	Controls the rotational direction of flagella during chemotaxis
VAA049_RS00465	COG0840	transmembrane signaling receptor activity
VAA049_RS00475	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VAA049_RS00485	COG0084	hydrolase, TatD family'
VAA049_RS00500	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VAA049_RS00500	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VAA049_RS00520	COG3078	GTPase activator activity
VAA049_RS00535	COG3071	HemY protein
VAA049_RS00540	COG2959	enzyme of heme biosynthesis
VAA049_RS00545	COG1587	Uroporphyrinogen-III synthase
VAA049_RS00550	COG0181	hydroxymethylbilane synthase activity
VAA049_RS00565	COG1965	Belongs to the frataxin family
VAA049_RS00575	COG0019	diaminopimelate decarboxylase activity
VAA049_RS00580	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
VAA049_RS00590	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
VAA049_RS00595	COG1011	Hydrolase
VAA049_RS00600	COG3287	FIST C domain
VAA049_RS00600	COG2200	EAL domain
VAA049_RS00600	COG2199	diguanylate cyclase activity
VAA049_RS00620	COG0561	phosphatase activity
VAA049_RS00625	COG2267	carboxylic ester hydrolase activity
VAA049_RS00630	COG1280	lysine exporter protein (LysE YggA)
VAA049_RS00635	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VAA049_RS00640	COG0783	Belongs to the Dps family
VAA049_RS00675	COG0742	ribosomal rna small subunit methyltransferase
VAA049_RS00680	COG0552	protein localization to endoplasmic reticulum
VAA049_RS00685	COG2884	Cell division ATP-binding protein ftsE
VAA049_RS00690	COG2177	Part of the ABC transporter FtsEX involved in
VAA049_RS00695	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VAA049_RS00700	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VAA049_RS00715	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VAA049_RS00725	COG1404	Belongs to the peptidase S8 family
VAA049_RS00730	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
VAA049_RS00795	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
VAA049_RS00800	COG5001	Diguanylate cyclase
VAA049_RS00800	COG3300	MHYT domain
VAA049_RS00810	COG3852	Histidine kinase
VAA049_RS00820	COG0174	glutamine synthetase
VAA049_RS00830	COG1217	gtp-binding protein TYPA
VAA049_RS00840	COG1295	ribonuclease BN
VAA049_RS00845	COG1490	D-aminoacyl-tRNA deacylase activity
VAA049_RS00850	COG0456	acetyltransferase
VAA049_RS00860	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
VAA049_RS00865	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
VAA049_RS00870	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
VAA049_RS00875	COG3031	protein transport across the cell outer membrane
VAA049_RS00885	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VAA049_RS00890	COG1459	type II secretion system
VAA049_RS00895	COG2165	general secretion pathway protein
VAA049_RS00900	COG2165	general secretion pathway protein
VAA049_RS00905	COG2165	general secretion pathway protein
VAA049_RS00910	COG4795	General secretion pathway protein
VAA049_RS00915	COG3156	type II secretion system protein K
VAA049_RS00920	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VAA049_RS00925	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
VAA049_RS00935	COG1218	3'(2'),5'-bisphosphate nucleotidase
VAA049_RS00940	COG0494	nUDIX hydrolase
VAA049_RS00950	COG1040	competence protein
VAA049_RS00955	COG0596	Alpha beta hydrolase
VAA049_RS00965	COG2183	response to ionizing radiation
VAA049_RS00970	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VAA049_RS00985	COG1129	ABC transporter
VAA049_RS00990	COG1172	Belongs to the binding-protein-dependent transport system permease family
VAA049_RS00995	COG1472	Belongs to the glycosyl hydrolase 3 family
VAA049_RS01020	COG2233	PERMEase
VAA049_RS01025	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
VAA049_RS01030	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VAA049_RS01035	COG1758	RNA polymerase activity
VAA049_RS01040	COG0194	GDP metabolic process
VAA049_RS01045	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
VAA049_RS01050	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VAA049_RS01070	COG4232	protein-disulfide reductase activity
VAA049_RS01080	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VAA049_RS01085	COG1027	Aspartate ammonia-lyase
VAA049_RS01090	COG3706	GGDEF domain
VAA049_RS01095	COG3030	protein affecting phage T7 exclusion by the F plasmid
VAA049_RS01100	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
VAA049_RS01110	COG2205	protein histidine kinase activity
VAA049_RS01115	COG0745	RESPONSE REGULATOR receiver
VAA049_RS01125	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
VAA049_RS01130	COG0205	6-phosphofructokinase activity
VAA049_RS01135	COG1494	fructose-1,6-bisphosphatase
VAA049_RS01140	COG3074	FtsZ-dependent cytokinesis
VAA049_RS01145	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
VAA049_RS01150	COG0460	homoserine dehydrogenase
VAA049_RS01150	COG0527	aspartate kinase activity
VAA049_RS01155	COG0626	cystathionine gamma-synthase activity
VAA049_RS01160	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
VAA049_RS01165	COG0281	malic enzyme
VAA049_RS01170	COG0254	rRNA binding
VAA049_RS01175	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
VAA049_RS01180	COG1609	Transcriptional regulator
VAA049_RS01185	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
VAA049_RS01190	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
VAA049_RS01195	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
VAA049_RS01200	COG1575	Belongs to the MenA family. Type 1 subfamily
VAA049_RS01205	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VAA049_RS01210	COG0534	Mate efflux family protein
VAA049_RS01215	COG0149	triose-phosphate isomerase activity
VAA049_RS01240	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
VAA049_RS01245	COG0459	protein refolding
VAA049_RS01255	COG1509	lysine 2,3-aminomutase activity
VAA049_RS01260	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VAA049_RS01270	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
VAA049_RS01275	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
VAA049_RS01280	COG1053	succinate dehydrogenase
VAA049_RS01285	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
VAA049_RS01290	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VAA049_RS01295	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
VAA049_RS01300	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
VAA049_RS01305	COG1045	serine acetyltransferase
VAA049_RS01315	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
VAA049_RS01320	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VAA049_RS01325	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
VAA049_RS01330	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VAA049_RS01335	COG0137	argininosuccinate synthase activity
VAA049_RS01340	COG0165	Argininosuccinate lyase
VAA049_RS01350	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VAA049_RS01355	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VAA049_RS01355	COG0678	peroxiredoxin activity
VAA049_RS01365	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
VAA049_RS01395	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
VAA049_RS01400	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
VAA049_RS01410	COG0338	D12 class N6 adenine-specific DNA methyltransferase
VAA049_RS01415	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
VAA049_RS01420	COG0546	phosphoglycolate phosphatase activity
VAA049_RS01425	COG0180	Tryptophanyl-tRNA synthetase
VAA049_RS01440	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VAA049_RS01450	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
VAA049_RS01475	COG3954	Phosphoribulokinase
VAA049_RS01485	COG0429	hydrolase of the alpha beta-hydrolase fold
VAA049_RS01495	COG0488	(ABC) transporter
VAA049_RS01500	COG2249	NAD(P)H dehydrogenase (quinone) activity
VAA049_RS01515	COG1047	Peptidyl-prolyl cis-trans
VAA049_RS01525	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
VAA049_RS01530	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
VAA049_RS01535	COG3083	sulfuric ester hydrolase activity
VAA049_RS01540	COG0557	exoribonuclease II activity
VAA049_RS01545	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VAA049_RS01550	COG0051	transcription antitermination factor activity, RNA binding
VAA049_RS01555	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
VAA049_RS01560	COG0088	Forms part of the polypeptide exit tunnel
VAA049_RS01565	COG0089	rRNA binding
VAA049_RS01570	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
VAA049_RS01575	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
VAA049_RS01580	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
VAA049_RS01585	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
VAA049_RS01590	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
VAA049_RS01595	COG0255	Belongs to the universal ribosomal protein uL29 family
VAA049_RS01600	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
VAA049_RS01605	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
VAA049_RS01610	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
VAA049_RS01615	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
VAA049_RS01620	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
VAA049_RS01625	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
VAA049_RS01635	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
VAA049_RS01640	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
VAA049_RS01645	COG1841	ribosomal large subunit assembly
VAA049_RS01655	COG0201	protein transport
VAA049_RS01660	COG0257	Belongs to the bacterial ribosomal protein bL36 family
VAA049_RS01665	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
VAA049_RS01670	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
VAA049_RS01675	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
VAA049_RS01680	COG0202	RNA polymerase activity
VAA049_RS01685	COG0203	ribosomal protein L17
VAA049_RS01695	COG0545	Peptidyl-prolyl cis-trans isomerase
VAA049_RS01700	COG3266	domain, Protein
VAA049_RS01700	COG3061	Opacity-associated protein A
VAA049_RS01705	COG0697	spore germination
VAA049_RS01710	COG2153	protein acetylation
VAA049_RS01715	COG0513	Belongs to the DEAD box helicase family
VAA049_RS01725	COG0737	Belongs to the 5'-nucleotidase family
VAA049_RS01730	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VAA049_RS01730	COG1648	precorrin-2 dehydrogenase activity
VAA049_RS01735	COG0175	sulfate reduction
VAA049_RS01740	COG2895	sulfate adenylyltransferase (ATP) activity
VAA049_RS01745	COG0529	Catalyzes the synthesis of activated sulfate
VAA049_RS01765	COG1136	(ABC) transporter
VAA049_RS01780	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
VAA049_RS01785	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VAA049_RS01790	COG0729	surface antigen
VAA049_RS01800	COG2105	PFAM AIG2 family protein
VAA049_RS01805	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
VAA049_RS01820	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VAA049_RS01825	COG0163	prenyltransferase activity
VAA049_RS01835	COG1178	ABC-type Fe3 transport system permease component
VAA049_RS01840	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
VAA049_RS01845	COG3028	Belongs to the UPF0307 family
VAA049_RS01850	COG0312	modulator of DNA gyrase
VAA049_RS01855	COG2239	Acts as a magnesium transporter
VAA049_RS01860	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VAA049_RS01865	COG1660	Displays ATPase and GTPase activities
VAA049_RS01870	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VAA049_RS01875	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VAA049_RS01885	COG1137	ATPase activity
VAA049_RS01890	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
VAA049_RS01905	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
VAA049_RS01905	COG0517	IMP dehydrogenase activity
VAA049_RS01920	COG1127	ABC transporter
VAA049_RS01925	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
VAA049_RS01930	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VAA049_RS01935	COG2854	intermembrane phospholipid transfer
VAA049_RS01945	COG5007	Belongs to the BolA IbaG family
VAA049_RS01950	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
VAA049_RS01960	COG0251	oxidation-reduction process
VAA049_RS01965	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
VAA049_RS01970	COG0540	Belongs to the ATCase OTCase family
VAA049_RS01980	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
VAA049_RS01990	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
VAA049_RS01995	COG0564	pseudouridine synthase activity
VAA049_RS02000	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VAA049_RS02005	COG0525	valine-tRNA ligase activity
VAA049_RS02010	COG2927	DNA polymerase III (CHI subunit)
VAA049_RS02015	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VAA049_RS02020	COG0795	lipopolysaccharide-transporting ATPase activity
VAA049_RS02025	COG0795	lipopolysaccharide-transporting ATPase activity
VAA049_RS02040	COG3437	response regulator, receiver
VAA049_RS02085	COG0066	3-isopropylmalate dehydratase activity
VAA049_RS02090	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
VAA049_RS02095	COG0473	3-isopropylmalate dehydrogenase activity
VAA049_RS02120	COG0583	DNA-binding transcription factor activity
VAA049_RS02125	COG1022	Amp-dependent synthetase and ligase
VAA049_RS02130	COG0028	Belongs to the TPP enzyme family
VAA049_RS02135	COG0440	acetolactate synthase activity
VAA049_RS02140	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VAA049_RS02145	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
VAA049_RS02150	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
VAA049_RS02155	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
VAA049_RS02160	COG3079	Belongs to the UPF0149 family
VAA049_RS02165	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VAA049_RS02170	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VAA049_RS02185	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
VAA049_RS02195	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
VAA049_RS02205	COG1595	DNA-templated transcription, initiation
VAA049_RS02220	COG3086	response to oxidative stress
VAA049_RS02225	COG0481	GTPase activity
VAA049_RS02235	COG0571	ribonuclease III activity
VAA049_RS02240	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
VAA049_RS02245	COG1381	Involved in DNA repair and RecF pathway recombination
VAA049_RS02250	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
VAA049_RS02280	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VAA049_RS02285	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VAA049_RS02290	COG3956	TIGRFAM MazG family protein
VAA049_RS02295	COG0504	CTP synthase activity
VAA049_RS02300	COG0148	phosphopyruvate hydratase activity
VAA049_RS02310	COG3267	Type II secretory pathway component ExeA
VAA049_RS02310	COG3409	Peptidoglycan-binding domain 1 protein
VAA049_RS02320	COG4991	sh3 domain protein
VAA049_RS02325	COG0306	phosphate transporter
VAA049_RS02330	COG1392	Phosphate transport regulator
VAA049_RS02335	COG3025	triphosphatase activity
VAA049_RS02340	COG0840	transmembrane signaling receptor activity
VAA049_RS02345	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
VAA049_RS02350	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
VAA049_RS02350	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
VAA049_RS02355	COG1538	Outer membrane efflux protein
VAA049_RS02360	COG0494	nUDIX hydrolase
VAA049_RS02365	COG3151	Protein conserved in bacteria
VAA049_RS02375	COG3150	esterase
VAA049_RS02380	COG0187	DNA topoisomerase II activity
VAA049_RS02385	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
VAA049_RS02395	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
VAA049_RS02400	COG0237	dephospho-CoA kinase activity
VAA049_RS02410	COG1459	type II secretion system
VAA049_RS02415	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VAA049_RS02435	COG0716	FMN binding
VAA049_RS02440	COG4974	Belongs to the 'phage' integrase family
VAA049_RS02445	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VAA049_RS02450	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
VAA049_RS02455	COG0737	Belongs to the 5'-nucleotidase family
VAA049_RS02460	COG2186	Transcriptional regulator
VAA049_RS02465	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
VAA049_RS02470	COG0508	dehydrogenase complex catalyzes the overall conversion of
VAA049_RS02475	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VAA049_RS02485	COG3116	cell division
VAA049_RS02490	COG0768	penicillin binding
VAA049_RS02495	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
VAA049_RS02500	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
VAA049_RS02510	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
VAA049_RS02515	COG0772	Belongs to the SEDS family
VAA049_RS02520	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
VAA049_RS02525	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VAA049_RS02530	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
VAA049_RS02535	COG0849	cell division
VAA049_RS02540	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
VAA049_RS02545	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
VAA049_RS02555	COG0653	protein targeting
VAA049_RS02565	COG0494	nUDIX hydrolase
VAA049_RS02570	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
VAA049_RS02580	COG0505	Belongs to the CarA family
VAA049_RS02585	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
VAA049_RS02605	COG0730	response to heat
VAA049_RS02610	COG0583	DNA-binding transcription factor activity
VAA049_RS02615	COG2860	membrane
VAA049_RS02620	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VAA049_RS02630	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
VAA049_RS02640	COG0493	'glutamate synthase
VAA049_RS02645	COG0070	glutamate synthase
VAA049_RS02645	COG0069	glutamate synthase activity
VAA049_RS02645	COG0067	glutamate synthase
VAA049_RS02655	COG0067	glutamate synthase
VAA049_RS02655	COG0069	glutamate synthase activity
VAA049_RS02655	COG0070	glutamate synthase
VAA049_RS02660	COG1242	4 iron, 4 sulfur cluster binding
VAA049_RS02665	COG3706	GGDEF domain
VAA049_RS02665	COG4251	negative regulation of phosphorylation
VAA049_RS02665	COG2203	Gaf domain
VAA049_RS02665	COG5001	Diguanylate cyclase
VAA049_RS02670	COG5002	protein histidine kinase activity
VAA049_RS02670	COG2198	Histidine kinase
VAA049_RS02670	COG0784	Response regulator, receiver
VAA049_RS02685	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VAA049_RS02700	COG0083	homoserine kinase activity
VAA049_RS02705	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
VAA049_RS02710	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
VAA049_RS02715	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
VAA049_RS02720	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
VAA049_RS02735	COG1115	amino acid carrier protein
VAA049_RS02740	COG3022	response to hydroperoxide
VAA049_RS02745	COG0084	hydrolase, TatD family'
VAA049_RS02750	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VAA049_RS02760	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
VAA049_RS02765	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
VAA049_RS02770	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
VAA049_RS02775	COG0813	purine-nucleoside phosphorylase activity
VAA049_RS02785	COG0560	Phosphoserine phosphatase
VAA049_RS02795	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
VAA049_RS02800	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VAA049_RS02805	COG1022	Amp-dependent synthetase and ligase
VAA049_RS02820	COG3250	beta-galactosidase activity
VAA049_RS02825	COG1609	Transcriptional regulator
VAA049_RS02830	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VAA049_RS02845	COG0569	domain protein
VAA049_RS02845	COG0189	ligase activity
VAA049_RS02850	COG0456	acetyltransferase
VAA049_RS02860	COG2171	N-acyltransferase activity
VAA049_RS02865	COG3141	response to X-ray
VAA049_RS02880	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
VAA049_RS02885	COG1074	ATP-dependent DNA helicase activity
VAA049_RS02890	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
VAA049_RS02905	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VAA049_RS02905	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VAA049_RS02915	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
VAA049_RS02920	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
VAA049_RS02925	COG2166	iron-sulfur cluster assembly
VAA049_RS02930	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VAA049_RS02935	COG0693	protein deglycase activity
VAA049_RS02940	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
VAA049_RS02945	COG3248	Nucleoside-binding outer membrane protein
VAA049_RS02955	COG1595	DNA-templated transcription, initiation
VAA049_RS02965	COG2211	Major facilitator Superfamily
VAA049_RS02970	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VAA049_RS02980	COG2813	Specifically methylates the guanine in position
VAA049_RS02985	COG0271	Belongs to the BolA IbaG family
VAA049_RS02990	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VAA049_RS02995	COG1805	sodium ion transport
VAA049_RS03000	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VAA049_RS03005	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VAA049_RS03010	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VAA049_RS03015	COG2871	sodium ion transport
VAA049_RS03020	COG1477	protein flavinylation
VAA049_RS03040	COG3706	GGDEF domain
VAA049_RS03045	COG0733	neurotransmitter:sodium symporter activity
VAA049_RS03055	COG0189	ligase activity
VAA049_RS03060	COG0189	ligase activity
VAA049_RS03060	COG4067	protein conserved in archaea
VAA049_RS03065	COG2195	Cleaves the N-terminal amino acid of tripeptides
VAA049_RS03070	COG2252	PERMEase
VAA049_RS03075	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
VAA049_RS03080	COG1073	alpha beta
VAA049_RS03090	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
VAA049_RS03095	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
VAA049_RS03100	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
VAA049_RS03105	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VAA049_RS03105	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VAA049_RS03120	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
VAA049_RS03125	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VAA049_RS03130	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
VAA049_RS03135	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
VAA049_RS03145	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
VAA049_RS03150	COG0024	Methionine aminopeptidase
VAA049_RS03155	COG0052	Belongs to the universal ribosomal protein uS2 family
VAA049_RS03160	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
VAA049_RS03165	COG0528	UMP kinase activity
VAA049_RS03170	COG0233	cytoplasmic translational termination
VAA049_RS03175	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
VAA049_RS03180	COG0575	Belongs to the CDS family
VAA049_RS03185	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
VAA049_RS03190	COG0750	zinc metalloprotease
VAA049_RS03200	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
VAA049_RS03205	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VAA049_RS03210	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VAA049_RS03215	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VAA049_RS03220	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VAA049_RS03225	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
VAA049_RS03230	COG0587	DNA-directed DNA polymerase activity
VAA049_RS03235	COG0825	malonyl-CoA metabolic process
VAA049_RS03240	COG0037	tRNA processing
VAA049_RS03250	COG3479	Phenolic acid decarboxylase
VAA049_RS03255	COG0347	Belongs to the P(II) protein family
VAA049_RS03260	COG3021	interspecies interaction between organisms
VAA049_RS03265	COG1388	LysM domain
VAA049_RS03265	COG0741	lytic transglycosylase activity
VAA049_RS03270	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VAA049_RS03275	COG2226	methyltransferase
VAA049_RS03280	COG0328	RNA-DNA hybrid ribonuclease activity
VAA049_RS03295	COG1960	acyl-CoA dehydrogenase activity
VAA049_RS03300	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VAA049_RS03305	COG0121	glutamine amidotransferase
VAA049_RS03310	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
VAA049_RS03315	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
VAA049_RS03320	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
VAA049_RS03330	COG1187	pseudouridine synthase activity
VAA049_RS03335	COG2840	Smr protein MutS2
VAA049_RS03365	COG2217	Heavy metal translocating P-type atpase
VAA049_RS03365	COG2608	mercury ion transmembrane transporter activity
VAA049_RS03370	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VAA049_RS03385	COG1629	transport
VAA049_RS03385	COG4774	siderophore transport
VAA049_RS03390	COG2375	cellular response to nickel ion
VAA049_RS03395	COG2226	methyltransferase
VAA049_RS03395	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
VAA049_RS03395	COG3433	isochorismatase activity
VAA049_RS03430	COG0784	Response regulator, receiver
VAA049_RS03430	COG0835	chemotaxis
VAA049_RS03435	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
VAA049_RS03440	COG1815	bacterial-type flagellum-dependent cell motility
VAA049_RS03455	COG1749	Flagellar hook protein flgE
VAA049_RS03460	COG4787	bacterial-type flagellum-dependent cell motility
VAA049_RS03470	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
VAA049_RS03475	COG1706	bacterial-type flagellum-dependent cell motility
VAA049_RS03480	COG1705	Flagellar rod assembly protein muramidase FlgJ
VAA049_RS03480	COG3951	Flagellar rod assembly protein muramidase FlgJ
VAA049_RS03500	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VAA049_RS03505	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VAA049_RS03590	COG0012	GTP binding
VAA049_RS03595	COG0193	aminoacyl-tRNA hydrolase activity
VAA049_RS03600	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
VAA049_RS03605	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
VAA049_RS03610	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
VAA049_RS03615	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
VAA049_RS03620	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
VAA049_RS03625	COG2890	protein-(glutamine-N5) methyltransferase activity
VAA049_RS03635	COG2912	Transglutaminase-like superfamily
VAA049_RS03640	COG2877	3-deoxy-8-phosphooctulonate synthase activity
VAA049_RS03645	COG0737	Belongs to the 5'-nucleotidase family
VAA049_RS03650	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
VAA049_RS03655	COG2233	PERMEase
VAA049_RS03675	COG1393	Belongs to the ArsC family
VAA049_RS03680	COG4783	chaperone-mediated protein folding
VAA049_RS03700	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
VAA049_RS03715	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
VAA049_RS03725	COG1876	peptidase activity
VAA049_RS03735	COG1393	Belongs to the ArsC family
VAA049_RS03755	COG2837	iron assimilation
VAA049_RS03760	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VAA049_RS03765	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VAA049_RS03770	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VAA049_RS03775	COG1334	flagellar protein FlaG
VAA049_RS03780	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
VAA049_RS03790	COG1516	flagellar protein fliS
VAA049_RS03810	COG1677	Flagellar hook-basal body complex protein FliE
VAA049_RS03820	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
VAA049_RS03825	COG1317	bacterial-type flagellum organization
VAA049_RS03845	COG1580	Controls the rotational direction of flagella during chemotaxis
VAA049_RS03870	COG1987	bacterial-type flagellum assembly
VAA049_RS03875	COG1684	flagellar biosynthetic protein fliR
VAA049_RS03885	COG2840	Smr protein MutS2
VAA049_RS03890	COG2890	protein-(glutamine-N5) methyltransferase activity
VAA049_RS03900	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
VAA049_RS03905	COG2860	membrane
VAA049_RS03910	COG3101	peptidyl-lysine hydroxylation
VAA049_RS03920	COG0431	NADPH-dependent FMN reductase
VAA049_RS03930	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VAA049_RS03935	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VAA049_RS03940	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VAA049_RS03945	COG0735	belongs to the Fur family
VAA049_RS03955	COG0583	DNA-binding transcription factor activity
VAA049_RS03965	COG1346	cytolysis
VAA049_RS03980	COG0596	Alpha beta hydrolase
VAA049_RS03985	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
VAA049_RS03990	COG0033	Phosphoglucomutase
VAA049_RS04000	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
VAA049_RS04005	COG0372	Belongs to the citrate synthase family
VAA049_RS04010	COG2009	succinate dehydrogenase
VAA049_RS04015	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
VAA049_RS04020	COG1053	succinate dehydrogenase
VAA049_RS04030	COG0567	Dehydrogenase, E1 component
VAA049_RS04035	COG0508	dehydrogenase complex catalyzes the overall conversion of
VAA049_RS04040	COG0045	succinate-CoA ligase (ADP-forming) activity
VAA049_RS04050	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VAA049_RS04055	COG1121	(ABC) transporter
VAA049_RS04060	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
VAA049_RS04065	COG4977	sequence-specific DNA binding
VAA049_RS04070	COG1918	ferrous iron import across plasma membrane
VAA049_RS04090	COG0018	arginyl-trna synthetase
VAA049_RS04100	COG1025	Belongs to the peptidase M16 family
VAA049_RS04105	COG2062	phosphohistidine phosphatase, SixA
VAA049_RS04135	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
VAA049_RS04140	COG2198	Histidine kinase
VAA049_RS04140	COG0784	Response regulator, receiver
VAA049_RS04140	COG0643	Histidine kinase
VAA049_RS04145	COG2201	protein-glutamate methylesterase activity
VAA049_RS04150	COG1192	Involved in chromosome partitioning
VAA049_RS04160	COG0835	chemotaxis
VAA049_RS04170	COG4133	protoheme IX ABC transporter activity
VAA049_RS04175	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VAA049_RS04180	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VAA049_RS04190	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
VAA049_RS04195	COG1138	Cytochrome C-type biogenesis protein
VAA049_RS04200	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VAA049_RS04205	COG3088	subunit of a heme lyase
VAA049_RS04205	COG4235	cytochrome complex assembly
VAA049_RS04215	COG2853	Lipoprotein
VAA049_RS04235	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
VAA049_RS04240	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VAA049_RS04245	COG0123	including yeast histone deacetylase and acetoin utilization protein
VAA049_RS04260	COG3083	sulfuric ester hydrolase activity
VAA049_RS04265	COG3082	Protein of unknown function (DUF1414)
VAA049_RS04270	COG3081	Nucleoid-associated protein
VAA049_RS04280	COG1757	Na H antiporter
VAA049_RS04285	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VAA049_RS04290	COG2095	MarC family integral membrane protein
VAA049_RS04295	COG1012	belongs to the aldehyde dehydrogenase family
VAA049_RS04295	COG1454	alcohol dehydrogenase
VAA049_RS04305	COG0659	secondary active sulfate transmembrane transporter activity
VAA049_RS04310	COG1530	ribonuclease E activity
VAA049_RS04325	COG0564	pseudouridine synthase activity
VAA049_RS04330	COG0424	maF-like protein
VAA049_RS04335	COG1399	metal-binding, possibly nucleic acid-binding protein
VAA049_RS04340	COG0333	Belongs to the bacterial ribosomal protein bL32 family
VAA049_RS04345	COG0416	fatty acid biosynthetic process
VAA049_RS04350	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VAA049_RS04360	COG1028	Short-chain dehydrogenase reductase Sdr
VAA049_RS04365	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VAA049_RS04370	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VAA049_RS04375	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VAA049_RS04380	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
VAA049_RS04385	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
VAA049_RS04395	COG0084	hydrolase, TatD family'
VAA049_RS04400	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VAA049_RS04400	COG1263	PTS System
VAA049_RS04405	COG0733	neurotransmitter:sodium symporter activity
VAA049_RS04420	COG4667	esterase of the alpha-beta hydrolase superfamily
VAA049_RS04430	COG1940	carbohydrate kinase activity
VAA049_RS04435	COG0835	chemotaxis
VAA049_RS04435	COG0784	Response regulator, receiver
VAA049_RS04450	COG2226	methyltransferase
VAA049_RS04460	COG0676	glucose-6-phosphate 1-epimerase activity
VAA049_RS04465	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VAA049_RS04470	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VAA049_RS04480	COG3139	Protein of unknown function (DUF1315)
VAA049_RS04485	COG0252	asparaginase activity
VAA049_RS04490	COG0616	signal peptide processing
VAA049_RS04495	COG1902	pentaerythritol trinitrate reductase activity
VAA049_RS04495	COG0446	pyridine nucleotide-disulphide oxidoreductase
VAA049_RS04500	COG0788	formyltetrahydrofolate deformylase activity
VAA049_RS04510	COG1199	ATP-dependent helicase activity
VAA049_RS04515	COG1214	PFAM Peptidase M22, glycoprotease
VAA049_RS04530	COG0596	Alpha beta hydrolase
VAA049_RS04540	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
VAA049_RS04560	COG0232	Belongs to the dGTPase family. Type 2 subfamily
VAA049_RS04565	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
VAA049_RS04570	COG0436	Aminotransferase
VAA049_RS04575	COG1169	isochorismate synthase
VAA049_RS04580	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
VAA049_RS04585	COG0596	Alpha beta hydrolase
VAA049_RS04605	COG3135	benzoate transporter
VAA049_RS04610	COG1396	sequence-specific DNA binding
VAA049_RS04615	COG0840	transmembrane signaling receptor activity
VAA049_RS04645	COG3015	lipoprotein NlpE involved in copper resistance
VAA049_RS04650	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
VAA049_RS04655	COG2894	cell division
VAA049_RS04660	COG0850	regulation of cytokinetic process
VAA049_RS04665	COG3100	YcgL domain-containing protein
VAA049_RS04670	COG2951	lytic endotransglycosylase activity
VAA049_RS04680	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VAA049_RS04690	COG3005	denitrification pathway
VAA049_RS04695	COG0243	molybdopterin cofactor binding
VAA049_RS04710	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VAA049_RS04720	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
VAA049_RS04755	COG4589	Belongs to the CDS family
VAA049_RS04765	COG5001	Diguanylate cyclase
VAA049_RS04765	COG3300	MHYT domain
VAA049_RS04780	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
VAA049_RS04785	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VAA049_RS04790	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VAA049_RS04795	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VAA049_RS04805	COG4191	Histidine kinase
VAA049_RS04815	COG0544	peptidyl-prolyl cis-trans isomerase activity
VAA049_RS04825	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
VAA049_RS04830	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
VAA049_RS04835	COG0776	regulation of translation
VAA049_RS04840	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VAA049_RS04845	COG1555	photosystem II stabilization
VAA049_RS04850	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
VAA049_RS04855	COG0539	negative regulation of cytoplasmic translation
VAA049_RS04860	COG0776	regulation of translation
VAA049_RS04865	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
VAA049_RS04870	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
VAA049_RS04890	COG0583	DNA-binding transcription factor activity
VAA049_RS04900	COG0686	Belongs to the AlaDH PNT family
VAA049_RS04910	COG1674	ftsk spoiiie
VAA049_RS04915	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
VAA049_RS04920	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VAA049_RS04925	COG2186	Transcriptional regulator
VAA049_RS04940	COG0537	adenosine 5'-monophosphoramidase activity
VAA049_RS04965	COG3150	esterase
VAA049_RS04970	COG1252	NADH dehydrogenase
VAA049_RS04990	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
VAA049_RS05000	COG4591	ABC-type transport system involved in lipoprotein release permease component
VAA049_RS05005	COG1136	(ABC) transporter
VAA049_RS05010	COG4591	ABC-type transport system involved in lipoprotein release permease component
VAA049_RS05020	COG2333	competence protein COMEC
VAA049_RS05020	COG0658	competence protein
VAA049_RS05025	COG1132	(ABC) transporter
VAA049_RS05030	COG1663	tetraacyldisaccharide 4'-kinase activity
VAA049_RS05035	COG2835	tetraacyldisaccharide 4'-kinase activity
VAA049_RS05040	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
VAA049_RS05045	COG2719	SpoVR family
VAA049_RS05050	COG2718	Belongs to the UPF0229 family
VAA049_RS05055	COG2766	serine protein kinase
VAA049_RS05060	COG3013	Belongs to the UPF0304 family
VAA049_RS05070	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VAA049_RS05075	COG0840	transmembrane signaling receptor activity
VAA049_RS05085	COG1882	Formate acetyltransferase
VAA049_RS05110	COG4160	amino acid transport
VAA049_RS05115	COG0708	Exodeoxyribonuclease III
VAA049_RS05120	COG0840	transmembrane signaling receptor activity
VAA049_RS05130	COG3923	Primosomal replication protein n
VAA049_RS05135	COG0730	response to heat
VAA049_RS05140	COG1199	ATP-dependent helicase activity
VAA049_RS05145	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VAA049_RS05155	COG2801	Transposase and inactivated derivatives
VAA049_RS05160	COG3012	SEC-C Motif Domain Protein
VAA049_RS05165	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VAA049_RS05170	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VAA049_RS05175	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VAA049_RS05180	COG0215	cysteine-tRNA ligase activity
VAA049_RS05185	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
VAA049_RS05190	COG0632	four-way junction helicase activity
VAA049_RS05200	COG1271	oxidase subunit
VAA049_RS05205	COG1294	oxidase, subunit
VAA049_RS05210	COG4890	Cyd operon protein YbgT
VAA049_RS05215	COG3790	cyd operon protein YbgE
VAA049_RS05220	COG0824	Thioesterase
VAA049_RS05225	COG0811	peptide transport
VAA049_RS05240	COG0823	Involved in the tonB-independent uptake of proteins
VAA049_RS05245	COG2885	chlorophyll binding
VAA049_RS05255	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
VAA049_RS05265	COG5002	protein histidine kinase activity
VAA049_RS05265	COG0784	Response regulator, receiver
VAA049_RS05275	COG1482	cell wall glycoprotein biosynthetic process
VAA049_RS05280	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VAA049_RS05280	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VAA049_RS05280	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VAA049_RS05285	COG2207	Transcriptional regulator
VAA049_RS05295	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VAA049_RS05300	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VAA049_RS05305	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VAA049_RS05310	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VAA049_RS05310	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VAA049_RS05310	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VAA049_RS05315	COG1012	belongs to the aldehyde dehydrogenase family
VAA049_RS05320	COG3284	Transcriptional regulator
VAA049_RS05325	COG4628	conserved protein (DUF2132)
VAA049_RS05335	COG0415	Belongs to the DNA photolyase family
VAA049_RS05365	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VAA049_RS05375	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VAA049_RS05375	COG3008	intermembrane lipid transfer
VAA049_RS05380	COG2995	paraquat-inducible protein a
VAA049_RS05390	COG1309	transcriptional regulator
VAA049_RS05395	COG1012	belongs to the aldehyde dehydrogenase family
VAA049_RS05415	COG1960	acyl-CoA dehydrogenase activity
VAA049_RS05420	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VAA049_RS05425	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
VAA049_RS05435	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
VAA049_RS05455	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VAA049_RS05460	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
VAA049_RS05465	COG0297	glycogen (starch) synthase activity
VAA049_RS05485	COG3070	regulator of competence-specific genes
VAA049_RS05490	COG1609	Transcriptional regulator
VAA049_RS05500	COG0745	RESPONSE REGULATOR receiver
VAA049_RS05505	COG1434	Gram-negative-bacterium-type cell wall biogenesis
VAA049_RS05510	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VAA049_RS05515	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
VAA049_RS05520	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
VAA049_RS05525	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
VAA049_RS05540	COG1032	radical SAM domain protein
VAA049_RS05545	COG5001	Diguanylate cyclase
VAA049_RS05550	COG0612	Peptidase, M16
VAA049_RS05565	COG0583	DNA-binding transcription factor activity
VAA049_RS05570	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
VAA049_RS05580	COG2350	Protein conserved in bacteria
VAA049_RS05585	COG1607	acyl-coa hydrolase
VAA049_RS05600	COG1434	Gram-negative-bacterium-type cell wall biogenesis
VAA049_RS05605	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VAA049_RS05615	COG2116	formate transmembrane transporter activity
VAA049_RS05625	COG4459	periplasmic nitrate reductase
VAA049_RS05630	COG3005	denitrification pathway
VAA049_RS05635	COG0243	molybdopterin cofactor binding
VAA049_RS05650	COG1227	inorganic diphosphatase activity
VAA049_RS05665	COG4172	Belongs to the ABC transporter superfamily
VAA049_RS05680	COG4168	peptide transport system, permease
VAA049_RS05690	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
VAA049_RS05695	COG1842	Phage shock protein A
VAA049_RS05710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VAA049_RS05725	COG2818	Glycosylase
VAA049_RS05730	COG0626	cystathionine gamma-synthase activity
VAA049_RS05740	COG0733	neurotransmitter:sodium symporter activity
VAA049_RS05745	COG0564	pseudouridine synthase activity
VAA049_RS05750	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
VAA049_RS05755	COG4136	ATPase activity
VAA049_RS05760	COG4135	transport system, permease component
VAA049_RS05765	COG4134	Bacterial extracellular solute-binding protein
VAA049_RS05775	COG3313	Fe-S protein
VAA049_RS05785	COG0842	Transport permease protein
VAA049_RS05790	COG1131	(ABC) transporter
VAA049_RS05795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VAA049_RS05800	COG0814	amino acid
VAA049_RS05810	COG2239	Acts as a magnesium transporter
VAA049_RS05815	COG0784	Response regulator, receiver
VAA049_RS05815	COG2205	protein histidine kinase activity
VAA049_RS05830	COG4934	collagen metabolic process
VAA049_RS05865	COG0840	transmembrane signaling receptor activity
VAA049_RS05880	COG4251	negative regulation of phosphorylation
VAA049_RS05880	COG5001	Diguanylate cyclase
VAA049_RS05880	COG2203	Gaf domain
VAA049_RS05880	COG3706	GGDEF domain
VAA049_RS05885	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
VAA049_RS05905	COG1061	Type III restriction enzyme res subunit
VAA049_RS05910	COG1187	pseudouridine synthase activity
VAA049_RS05915	COG2814	Major facilitator Superfamily
VAA049_RS05925	COG0702	epimerase
VAA049_RS05930	COG0534	Mate efflux family protein
VAA049_RS05935	COG4181	ATPase activity
VAA049_RS05940	COG0577	efflux transmembrane transporter activity
VAA049_RS05950	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VAA049_RS05960	COG1748	Saccharopine dehydrogenase
VAA049_RS05975	COG1538	Outer membrane efflux protein
VAA049_RS06005	COG0583	DNA-binding transcription factor activity
VAA049_RS06015	COG1451	nucleotide metabolic process
VAA049_RS06030	COG3063	Type IV pilus biogenesis stability protein PilW
VAA049_RS06035	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
VAA049_RS06055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VAA049_RS06070	COG3290	protein histidine kinase activity
VAA049_RS06075	COG4565	transcriptional regulatory protein
VAA049_RS06085	COG0784	Response regulator, receiver
VAA049_RS06085	COG0835	chemotaxis
VAA049_RS06125	COG1085	galactose-1-phosphate uridylyltransferase
VAA049_RS06130	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
VAA049_RS06135	COG2017	converts alpha-aldose to the beta-anomer
VAA049_RS06145	COG2200	EAL domain
VAA049_RS06145	COG2199	diguanylate cyclase activity
VAA049_RS06160	COG3527	Alpha-acetolactate decarboxylase
VAA049_RS06175	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
VAA049_RS06185	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
VAA049_RS06200	COG3097	Belongs to the UPF0267 family
VAA049_RS06225	COG1271	oxidase subunit
VAA049_RS06230	COG1294	oxidase, subunit
VAA049_RS06235	COG1136	(ABC) transporter
VAA049_RS06235	COG4591	ABC-type transport system involved in lipoprotein release permease component
VAA049_RS06240	COG0577	efflux transmembrane transporter activity
VAA049_RS06240	COG1136	(ABC) transporter
VAA049_RS06265	COG0583	DNA-binding transcription factor activity
VAA049_RS06275	COG2723	6-phospho-beta-galactosidase activity
VAA049_RS06280	COG1609	Transcriptional regulator
VAA049_RS06285	COG0251	oxidation-reduction process
VAA049_RS06290	COG2731	YhcH YjgK YiaL family protein
VAA049_RS06295	COG0584	glycerophosphoryl diester phosphodiesterase
VAA049_RS06300	COG1349	DNA-binding transcription factor activity
VAA049_RS06305	COG3842	ATPase activity
VAA049_RS06310	COG0395	ABC-type sugar transport system, permease component
VAA049_RS06315	COG1175	transmembrane transport
VAA049_RS06330	COG0811	peptide transport
VAA049_RS06335	COG0811	peptide transport
VAA049_RS06340	COG0848	biopolymer transport protein
VAA049_RS06345	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
VAA049_RS06355	COG1793	dna ligase
VAA049_RS06365	COG0534	Mate efflux family protein
VAA049_RS06375	COG3001	Fructosamine kinase
VAA049_RS06385	COG0791	NLP P60 protein
VAA049_RS06390	COG3290	protein histidine kinase activity
VAA049_RS06390	COG0840	transmembrane signaling receptor activity
VAA049_RS06400	COG3148	PFAM DTW domain containing protein
VAA049_RS06405	COG1940	carbohydrate kinase activity
VAA049_RS06430	COG0303	'Molybdopterin
VAA049_RS06435	COG0746	molybdenum cofactor guanylyltransferase activity
VAA049_RS06440	COG3842	ATPase activity
VAA049_RS06445	COG4662	Binding-protein-dependent transport system inner membrane component
VAA049_RS06455	COG2204	response regulator
VAA049_RS06460	COG3852	Histidine kinase
VAA049_RS06465	COG0488	(ABC) transporter
VAA049_RS06470	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
VAA049_RS06500	COG3383	formate dehydrogenase (NAD+) activity
VAA049_RS06500	COG0243	molybdopterin cofactor binding
VAA049_RS06505	COG0437	4 iron, 4 sulfur cluster binding
VAA049_RS06520	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
VAA049_RS06525	COG1666	GTP binding
VAA049_RS06530	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VAA049_RS06545	COG2996	Protein conserved in bacteria
VAA049_RS06555	COG3008	intermembrane lipid transfer
VAA049_RS06560	COG2995	paraquat-inducible protein a
VAA049_RS06565	COG1132	(ABC) transporter
VAA049_RS06570	COG1956	GAF domain-containing protein
VAA049_RS06575	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
VAA049_RS06590	COG0308	aminopeptidase N
VAA049_RS06605	COG0167	dihydroorotate dehydrogenase activity
VAA049_RS06615	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VAA049_RS06615	COG0116	Belongs to the methyltransferase superfamily
VAA049_RS06625	COG0488	(ABC) transporter
VAA049_RS06640	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VAA049_RS06645	COG1067	ATP-dependent peptidase activity
VAA049_RS06650	COG3120	sequence-specific DNA binding
VAA049_RS06845	COG1073	alpha beta
VAA049_RS06845	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
VAA049_RS06845	COG3064	Membrane
VAA049_RS06850	COG2994	toxin metabolic process
VAA049_RS06875	COG0784	Response regulator, receiver
VAA049_RS06875	COG2205	protein histidine kinase activity
VAA049_RS06890	COG3278	Belongs to the heme-copper respiratory oxidase family
VAA049_RS06905	COG2010	Cytochrome c
VAA049_RS06915	COG2217	Heavy metal translocating P-type atpase
VAA049_RS06930	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VAA049_RS06935	COG0589	response to stress
VAA049_RS06940	COG0037	tRNA processing
VAA049_RS06960	COG3842	ATPase activity
VAA049_RS06970	COG1177	transmembrane transport
VAA049_RS06980	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VAA049_RS06995	COG1115	amino acid carrier protein
VAA049_RS07000	COG1280	lysine exporter protein (LysE YggA)
VAA049_RS07020	COG3501	Rhs element vgr protein
VAA049_RS07030	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
VAA049_RS07040	COG2814	Major facilitator Superfamily
VAA049_RS07045	COG1566	PFAM secretion protein HlyD family protein
VAA049_RS07050	COG1538	Outer membrane efflux protein
VAA049_RS07060	COG0513	Belongs to the DEAD box helicase family
VAA049_RS07070	COG0840	transmembrane signaling receptor activity
VAA049_RS07075	COG3290	protein histidine kinase activity
VAA049_RS07075	COG0840	transmembrane signaling receptor activity
VAA049_RS07080	COG0835	chemotaxis
VAA049_RS07085	COG2201	protein-glutamate methylesterase activity
VAA049_RS07095	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
VAA049_RS07100	COG0784	Response regulator, receiver
VAA049_RS07100	COG0643	Histidine kinase
VAA049_RS07100	COG2198	Histidine kinase
VAA049_RS07105	COG0643	Histidine kinase
VAA049_RS07105	COG2198	Histidine kinase
VAA049_RS07115	COG0745	RESPONSE REGULATOR receiver
VAA049_RS07130	COG0415	Belongs to the DNA photolyase family
VAA049_RS07135	COG0477	Major facilitator Superfamily
VAA049_RS07140	COG0583	DNA-binding transcription factor activity
VAA049_RS07150	COG0095	Lipoate-protein ligase
VAA049_RS07155	COG0443	Heat shock 70 kDa protein
VAA049_RS07165	COG1643	Atp-dependent helicase
VAA049_RS07205	COG0443	Heat shock 70 kDa protein
VAA049_RS07210	COG0443	Heat shock 70 kDa protein
VAA049_RS07215	COG3706	GGDEF domain
VAA049_RS07245	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
VAA049_RS07250	COG0602	queuosine metabolic process
VAA049_RS07255	COG0561	phosphatase activity
VAA049_RS07265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VAA049_RS07270	COG4597	amino acid ABC transporter
VAA049_RS07275	COG0765	amino acid transport
VAA049_RS07280	COG1126	abc transporter atp-binding protein
VAA049_RS07285	COG0670	Belongs to the BI1 family
VAA049_RS07290	COG2920	part of a sulfur-relay system
VAA049_RS07295	COG1254	Belongs to the acylphosphatase family
VAA049_RS07300	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VAA049_RS07305	COG3706	GGDEF domain
VAA049_RS07320	COG4999	Histidine kinase
VAA049_RS07320	COG3437	response regulator, receiver
VAA049_RS07320	COG2205	protein histidine kinase activity
VAA049_RS07320	COG3850	Histidine kinase
VAA049_RS07325	COG3437	response regulator, receiver
VAA049_RS07330	COG0625	glutathione transferase activity
VAA049_RS07340	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
VAA049_RS07350	COG2195	Cleaves the N-terminal amino acid of tripeptides
VAA049_RS07380	COG0372	Belongs to the citrate synthase family
VAA049_RS07385	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
VAA049_RS07430	COG1129	ABC transporter
VAA049_RS07465	COG0745	RESPONSE REGULATOR receiver
VAA049_RS07470	COG5002	protein histidine kinase activity
VAA049_RS07475	COG3713	MltA-interacting MipA family protein
VAA049_RS07480	COG2990	Protein conserved in bacteria
VAA049_RS07490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VAA049_RS07490	COG4191	Histidine kinase
VAA049_RS07495	COG0471	metal ion transport
VAA049_RS07505	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VAA049_RS07520	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VAA049_RS07530	COG3768	UPF0283 membrane protein
VAA049_RS07535	COG3106	COG3106 Predicted ATPase
VAA049_RS07550	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VAA049_RS07555	COG0494	nUDIX hydrolase
VAA049_RS07565	COG1760	l-serine dehydratase
VAA049_RS07570	COG0720	synthase
VAA049_RS07580	COG0017	Asparaginyl-tRNA synthetase
VAA049_RS07585	COG0351	phosphomethylpyrimidine kinase
VAA049_RS07590	COG3437	response regulator, receiver
VAA049_RS07590	COG2770	Histidine kinase
VAA049_RS07595	COG1448	Aminotransferase
VAA049_RS07610	COG0840	transmembrane signaling receptor activity
VAA049_RS07615	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
VAA049_RS07620	COG2943	transferase activity, transferring hexosyl groups
VAA049_RS07625	COG1609	Transcriptional regulator
VAA049_RS07635	COG1486	melibiose metabolic process
VAA049_RS07640	COG1447	Phosphotransferase system cellobiose-specific component IIA
VAA049_RS07650	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VAA049_RS07655	COG0726	polysaccharide deacetylase
VAA049_RS07660	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VAA049_RS07665	COG1846	Transcriptional regulator
VAA049_RS07690	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
VAA049_RS07705	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VAA049_RS07710	COG3108	Peptidase M15
VAA049_RS07740	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VAA049_RS07750	COG2814	Major facilitator Superfamily
VAA049_RS07760	COG1054	Belongs to the UPF0176 family
VAA049_RS07770	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
VAA049_RS07775	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VAA049_RS07780	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VAA049_RS07820	COG2801	Transposase and inactivated derivatives
VAA049_RS07825	COG1418	mRNA catabolic process
VAA049_RS07960	COG4115	mRNA cleavage
VAA049_RS07965	COG2161	toxin-antitoxin pair type II binding
VAA049_RS08050	COG0456	acetyltransferase
VAA049_RS08075	COG5002	protein histidine kinase activity
VAA049_RS08095	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
VAA049_RS08100	COG0291	Belongs to the bacterial ribosomal protein bL35 family
VAA049_RS08260	COG3772	lysozyme
VAA049_RS08360	COG0404	The glycine cleavage system catalyzes the degradation of glycine
VAA049_RS08370	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VAA049_RS08375	COG0509	glycine decarboxylation via glycine cleavage system
VAA049_RS08380	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
VAA049_RS08380	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
VAA049_RS08400	COG1686	Belongs to the peptidase S11 family
VAA049_RS08420	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
VAA049_RS08445	COG5002	protein histidine kinase activity
VAA049_RS08450	COG0745	RESPONSE REGULATOR receiver
VAA049_RS08470	COG0366	Alpha amylase catalytic
VAA049_RS08505	COG0561	phosphatase activity
VAA049_RS08510	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
VAA049_RS08515	COG3623	hexulose-6-phosphate isomerase
VAA049_RS08525	COG0745	RESPONSE REGULATOR receiver
VAA049_RS08545	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
VAA049_RS08560	COG2207	Transcriptional regulator
VAA049_RS08565	COG4604	ABC transporter, ATP-binding protein
VAA049_RS08570	COG4605	iron ion homeostasis
VAA049_RS08575	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VAA049_RS08610	COG5380	lipid catabolic process
VAA049_RS08615	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
VAA049_RS08620	COG0840	transmembrane signaling receptor activity
VAA049_RS08630	COG3240	lipase activity
VAA049_RS08635	COG3706	GGDEF domain
VAA049_RS08650	COG2814	Major facilitator Superfamily
VAA049_RS08655	COG1757	Na H antiporter
VAA049_RS08665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VAA049_RS08665	COG4191	Histidine kinase
VAA049_RS08670	COG0784	Response regulator, receiver
VAA049_RS08670	COG3437	response regulator, receiver
VAA049_RS08675	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
VAA049_RS08680	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
VAA049_RS08685	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VAA049_RS08690	COG0513	Belongs to the DEAD box helicase family
VAA049_RS08715	COG0516	GMP reductase activity
VAA049_RS08730	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VAA049_RS08740	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VAA049_RS08745	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
VAA049_RS08745	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
VAA049_RS08770	COG3036	rescue of stalled ribosome
VAA049_RS08775	COG1278	Cold shock
VAA049_RS08780	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VAA049_RS08780	COG1017	nitric oxide dioxygenase activity
VAA049_RS08785	COG3604	Transcriptional regulator
VAA049_RS08795	COG2195	Cleaves the N-terminal amino acid of tripeptides
VAA049_RS08800	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VAA049_RS08815	COG0840	transmembrane signaling receptor activity
VAA049_RS08820	COG0714	Associated with various cellular activities
VAA049_RS08840	COG2304	oxidoreductase activity
VAA049_RS08855	COG1278	Cold shock
VAA049_RS08860	COG5002	protein histidine kinase activity
VAA049_RS08860	COG5001	Diguanylate cyclase
VAA049_RS08870	COG3530	Putative quorum-sensing-regulated virulence factor
VAA049_RS08885	COG0814	amino acid
VAA049_RS08890	COG0589	response to stress
VAA049_RS08900	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
VAA049_RS08900	COG2111	Na H antiporter
VAA049_RS08905	COG1006	Multisubunit Na H antiporter MnhC subunit
VAA049_RS08910	COG0651	ATP synthesis coupled electron transport
VAA049_RS08915	COG1863	multisubunit Na H antiporter MnhE subunit
VAA049_RS08920	COG2212	antiporter activity
VAA049_RS08925	COG1320	monovalent cation:proton antiporter activity
VAA049_RS08935	COG0242	peptide deformylase activity
VAA049_RS08945	COG0579	oxidoreductase
VAA049_RS08985	COG2271	Major facilitator Superfamily
VAA049_RS08990	COG0584	glycerophosphoryl diester phosphodiesterase
VAA049_RS09000	COG5002	protein histidine kinase activity
VAA049_RS09000	COG3447	MASE1 domain protein
VAA049_RS09000	COG5001	Diguanylate cyclase
VAA049_RS09005	COG1609	Transcriptional regulator
VAA049_RS09010	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VAA049_RS09015	COG1879	ABC-type sugar transport system periplasmic component
VAA049_RS09020	COG1172	Belongs to the binding-protein-dependent transport system permease family
VAA049_RS09025	COG1129	ABC transporter
VAA049_RS09030	COG1869	D-ribose catabolic process
VAA049_RS09050	COG2801	Transposase and inactivated derivatives
VAA049_RS09055	COG3409	Peptidoglycan-binding domain 1 protein
VAA049_RS09055	COG3501	Rhs element vgr protein
VAA049_RS09085	COG3829	transcription factor binding
VAA049_RS09150	COG0564	pseudouridine synthase activity
VAA049_RS09160	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VAA049_RS09165	COG2200	EAL domain
VAA049_RS09165	COG2771	luxR family
VAA049_RS09175	COG0673	inositol 2-dehydrogenase activity
VAA049_RS09180	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
VAA049_RS09215	COG1342	Belongs to the UPF0251 family
VAA049_RS09225	COG1301	dicarboxylic acid transport
VAA049_RS09250	COG2814	Major facilitator Superfamily
VAA049_RS09255	COG0583	DNA-binding transcription factor activity
VAA049_RS09260	COG5001	Diguanylate cyclase
VAA049_RS09260	COG3300	MHYT domain
VAA049_RS09265	COG0739	heme binding
VAA049_RS09275	COG0659	secondary active sulfate transmembrane transporter activity
VAA049_RS09280	COG3314	Sporulation integral membrane protein YlbJ
VAA049_RS09295	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VAA049_RS09300	COG0581	inorganic phosphate transmembrane transporter activity
VAA049_RS09305	COG0573	inorganic phosphate transmembrane transporter activity
VAA049_RS09310	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
VAA049_RS09340	COG1770	oligopeptidase
VAA049_RS09345	COG0513	Belongs to the DEAD box helicase family
VAA049_RS09360	COG1376	ErfK ybiS ycfS ynhG family protein
VAA049_RS09360	COG1388	LysM domain
VAA049_RS09365	COG0415	Belongs to the DNA photolyase family
VAA049_RS09375	COG3272	Protein of unknown function (DUF1722)
VAA049_RS09385	COG0813	purine-nucleoside phosphorylase activity
VAA049_RS09410	COG1566	PFAM secretion protein HlyD family protein
VAA049_RS09430	COG0786	glutamate:sodium symporter activity
VAA049_RS09445	COG1999	signal sequence binding
VAA049_RS09455	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
VAA049_RS09460	COG0671	phosphoesterase, PA-phosphatase related
VAA049_RS09505	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
VAA049_RS09510	COG0471	metal ion transport
VAA049_RS09540	COG4104	PAAR repeat-containing protein
VAA049_RS09545	COG3501	Rhs element vgr protein
VAA049_RS09555	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
VAA049_RS09560	COG1640	4-alpha-glucanotransferase
VAA049_RS09565	COG0058	SHG alpha-glucan phosphorylase activity
VAA049_RS09570	COG2909	trisaccharide binding
VAA049_RS09590	COG2084	Dehydrogenase
VAA049_RS09595	COG0217	transcriptional regulatory protein
VAA049_RS09630	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VAA049_RS09635	COG1444	tRNA N-acetyltransferase activity
VAA049_RS09655	COG4221	oxidoreductase activity
VAA049_RS09670	COG0642	Histidine kinase
VAA049_RS09675	COG2194	sulfuric ester hydrolase activity
VAA049_RS09685	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VAA049_RS09690	COG0601	transmembrane transport
VAA049_RS09710	COG0643	Histidine kinase
VAA049_RS09710	COG2198	Histidine kinase
VAA049_RS09715	COG0835	chemotaxis
VAA049_RS09720	COG0835	chemotaxis
VAA049_RS09725	COG0840	transmembrane signaling receptor activity
VAA049_RS09730	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
VAA049_RS09795	COG1262	PFAM Formylglycine-generating sulfatase enzyme
VAA049_RS09820	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VAA049_RS09850	COG1982	Orn Lys Arg decarboxylase major
VAA049_RS09855	COG0531	amino acid
VAA049_RS09865	COG1901	pseudouridine methyltransferase
VAA049_RS09875	COG4221	oxidoreductase activity
VAA049_RS09880	COG0840	transmembrane signaling receptor activity
VAA049_RS09890	COG2910	NAD(P)H-binding
VAA049_RS09900	COG1335	isochorismatase
VAA049_RS09915	COG0697	spore germination
VAA049_RS09935	COG0673	inositol 2-dehydrogenase activity
VAA049_RS09940	COG3722	fumarate hydratase activity
VAA049_RS09945	COG0246	Mannitol dehydrogenase
VAA049_RS09950	COG2213	PTS system mannitol-specific
VAA049_RS09950	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
VAA049_RS09955	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VAA049_RS09960	COG4597	amino acid ABC transporter
VAA049_RS09965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VAA049_RS09975	COG1126	abc transporter atp-binding protein
VAA049_RS09980	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VAA049_RS09990	COG0840	transmembrane signaling receptor activity
VAA049_RS10005	COG0840	transmembrane signaling receptor activity
VAA049_RS10020	COG4580	involved in the transport of maltose and maltodextrins
VAA049_RS10035	COG0363	glucosamine-6-phosphate deaminase activity
VAA049_RS10060	COG2259	Doxx family
VAA049_RS10065	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
VAA049_RS10070	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
VAA049_RS10080	COG0471	metal ion transport
VAA049_RS10090	COG4565	transcriptional regulatory protein
VAA049_RS10095	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
VAA049_RS10100	COG3366	ferrous iron transmembrane transporter activity
VAA049_RS10105	COG0700	Nucleoside recognition
VAA049_RS10115	COG0697	spore germination
VAA049_RS10120	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VAA049_RS10125	COG1764	response to oxidative stress
VAA049_RS10130	COG1846	Transcriptional regulator
VAA049_RS10150	COG2207	Transcriptional regulator
VAA049_RS10155	COG1280	lysine exporter protein (LysE YggA)
VAA049_RS10165	COG1902	pentaerythritol trinitrate reductase activity
VAA049_RS10175	COG1132	(ABC) transporter
VAA049_RS10185	COG0513	Belongs to the DEAD box helicase family
VAA049_RS10190	COG0534	Mate efflux family protein
VAA049_RS10195	COG0840	transmembrane signaling receptor activity
VAA049_RS10205	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
VAA049_RS10220	COG1620	l-lactate permease
VAA049_RS10225	COG0583	DNA-binding transcription factor activity
VAA049_RS10245	COG4172	Belongs to the ABC transporter superfamily
VAA049_RS10255	COG1067	ATP-dependent peptidase activity
VAA049_RS10260	COG0840	transmembrane signaling receptor activity
VAA049_RS10270	COG2211	Major facilitator Superfamily
VAA049_RS10280	COG3123	guanosine phosphorylase activity
VAA049_RS10285	COG1741	Belongs to the pirin family
VAA049_RS10295	COG5001	Diguanylate cyclase
VAA049_RS10300	COG0583	DNA-binding transcription factor activity
VAA049_RS10340	COG3706	GGDEF domain
VAA049_RS10345	COG1846	Transcriptional regulator
VAA049_RS10350	COG0784	Response regulator, receiver
VAA049_RS10350	COG0835	chemotaxis
VAA049_RS10355	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VAA049_RS10365	COG0393	Putative heavy-metal-binding
VAA049_RS10380	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VAA049_RS10385	COG3842	ATPase activity
VAA049_RS10395	COG1175	transmembrane transport
VAA049_RS10400	COG3833	ABC-type maltose transport systems, permease component
VAA049_RS10415	COG1349	DNA-binding transcription factor activity
VAA049_RS10420	COG2199	diguanylate cyclase activity
VAA049_RS10445	COG1278	Cold shock
VAA049_RS10450	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
VAA049_RS10455	COG2354	Protein conserved in bacteria
VAA049_RS10460	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VAA049_RS10470	COG3152	Membrane
VAA049_RS10480	COG0418	dihydroorotase activity
VAA049_RS10485	COG0633	Ferredoxin
VAA049_RS10485	COG3217	Mosc domain protein beta barrel domain protein
VAA049_RS10485	COG3217	Mosc domain protein beta barrel domain protein
VAA049_RS10485	COG0633	Ferredoxin
VAA049_RS10520	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
VAA049_RS10525	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VAA049_RS10530	COG4558	Periplasmic binding protein
VAA049_RS10535	COG0848	biopolymer transport protein
VAA049_RS10540	COG0811	peptide transport
VAA049_RS10545	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
VAA049_RS10555	COG3721	Heme iron utilization protein
VAA049_RS10560	COG0748	coenzyme F420 binding
VAA049_RS10570	COG3835	regulator
VAA049_RS10575	COG2610	gluconate transmembrane transporter activity
VAA049_RS10580	COG1929	Belongs to the glycerate kinase type-1 family
VAA049_RS10605	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
VAA049_RS10610	COG0363	glucosamine-6-phosphate deaminase activity
VAA049_RS10615	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
VAA049_RS10620	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
VAA049_RS10625	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
VAA049_RS10645	COG0346	lactoylglutathione lyase activity
VAA049_RS10655	COG2873	o-acetylhomoserine
VAA049_RS10665	COG1063	alcohol dehydrogenase
VAA049_RS10720	COG0583	DNA-binding transcription factor activity
VAA049_RS10725	COG3048	D-serine ammonia-lyase activity
VAA049_RS10735	COG1294	oxidase, subunit
VAA049_RS10740	COG1271	oxidase subunit
VAA049_RS10745	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VAA049_RS10750	COG1686	Belongs to the peptidase S11 family
VAA049_RS10760	COG3047	cAMP biosynthetic process
VAA049_RS10770	COG3227	Zinc metalloprotease (Elastase)
VAA049_RS10780	COG2267	carboxylic ester hydrolase activity
VAA049_RS10785	COG2067	long-chain fatty acid transport protein
VAA049_RS10800	COG0366	Alpha amylase catalytic
VAA049_RS10805	COG4989	oxidoreductase activity
VAA049_RS10825	COG0531	amino acid
VAA049_RS10855	COG1765	OsmC-like protein
VAA049_RS10860	COG1253	flavin adenine dinucleotide binding
VAA049_RS10865	COG0110	maltose O-acetyltransferase activity
VAA049_RS10885	COG2264	protein methyltransferase activity
VAA049_RS10900	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VAA049_RS10905	COG3186	Phenylalanine-4-hydroxylase
VAA049_RS10910	COG2154	pterin-4-alpha-carbinolamine dehydratase
VAA049_RS10915	COG0456	acetyltransferase
VAA049_RS10920	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
VAA049_RS10925	COG0662	Cupin 2, conserved barrel domain protein
VAA049_RS10930	COG0527	aspartate kinase activity
VAA049_RS10940	COG0459	protein refolding
VAA049_RS10945	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
VAA049_RS10950	COG2239	Acts as a magnesium transporter
VAA049_RS10960	COG1166	arginine decarboxylase activity
VAA049_RS10965	COG0010	Belongs to the arginase family
VAA049_RS10975	COG3227	Zinc metalloprotease (Elastase)
VAA049_RS10980	COG3397	chitin binding
VAA049_RS10985	COG3046	protein related to deoxyribodipyrimidine photolyase
VAA049_RS10995	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
VAA049_RS11010	COG0513	Belongs to the DEAD box helicase family
VAA049_RS11020	COG1368	sulfuric ester hydrolase activity
VAA049_RS11025	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VAA049_RS11040	COG0546	phosphoglycolate phosphatase activity
VAA049_RS11055	COG0484	heat shock protein binding
VAA049_RS11070	COG5001	Diguanylate cyclase
VAA049_RS11070	COG1716	ATPase activity
VAA049_RS11075	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VAA049_RS11085	COG4181	ATPase activity
VAA049_RS11090	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
VAA049_RS11105	COG1984	allophanate hydrolase subunit 2
VAA049_RS11115	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
VAA049_RS11125	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VAA049_RS11130	COG0840	transmembrane signaling receptor activity
VAA049_RS11135	COG0814	amino acid
VAA049_RS11145	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
VAA049_RS11150	COG0513	Belongs to the DEAD box helicase family
VAA049_RS11155	COG1309	transcriptional regulator
VAA049_RS11165	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
VAA049_RS11170	COG0494	nUDIX hydrolase
VAA049_RS11180	COG2425	protein containing a von Willebrand factor type A (vWA) domain
VAA049_RS11190	COG1126	abc transporter atp-binding protein
VAA049_RS11195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VAA049_RS11200	COG4215	(ABC) transporter
VAA049_RS11205	COG4160	amino acid transport
VAA049_RS11210	COG0583	DNA-binding transcription factor activity
VAA049_RS11240	COG3118	belongs to the thioredoxin family
VAA049_RS11245	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VAA049_RS11250	COG0247	lactate metabolic process
VAA049_RS11260	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
VAA049_RS11270	COG1879	ABC-type sugar transport system periplasmic component
VAA049_RS11275	COG5002	protein histidine kinase activity
VAA049_RS11275	COG0784	Response regulator, receiver
VAA049_RS11310	COG1492	cobalamin metabolic process
VAA049_RS11315	COG0725	ABC transporter, periplasmic molybdate-binding protein
VAA049_RS11320	COG4149	molybdate abc transporter
VAA049_RS11325	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
VAA049_RS11355	COG1289	transmembrane transporter activity
VAA049_RS11360	COG0210	DNA helicase
VAA049_RS11375	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
VAA049_RS11380	COG1335	isochorismatase
VAA049_RS11385	COG1803	Methylglyoxal synthase
VAA049_RS11390	COG1879	ABC-type sugar transport system periplasmic component
VAA049_RS11395	COG2198	Histidine kinase
VAA049_RS11395	COG2205	protein histidine kinase activity
VAA049_RS11395	COG0784	Response regulator, receiver
VAA049_RS11400	COG0469	pyruvate kinase activity
VAA049_RS11405	COG2271	Major facilitator Superfamily
VAA049_RS11415	COG4191	Histidine kinase
VAA049_RS11430	COG1979	alcohol dehydrogenase
VAA049_RS11440	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
VAA049_RS11460	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VAA049_RS11465	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VAA049_RS11475	COG0183	Belongs to the thiolase family
VAA049_RS11485	COG3243	poly(R)-hydroxyalkanoic acid synthase
VAA049_RS11490	COG3842	ATPase activity
VAA049_RS11500	COG1840	ABC-type Fe3 transport system, periplasmic component
VAA049_RS11505	COG2271	Major facilitator Superfamily
VAA049_RS11510	COG3851	Histidine kinase
VAA049_RS11515	COG2197	response regulator
VAA049_RS11520	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
VAA049_RS11540	COG0243	molybdopterin cofactor binding
VAA049_RS11550	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VAA049_RS11555	COG3850	Histidine kinase
VAA049_RS11560	COG2197	response regulator
VAA049_RS11565	COG1760	l-serine dehydratase
VAA049_RS11570	COG3069	C4-dicarboxylate transmembrane transporter activity
VAA049_RS11580	COG0840	transmembrane signaling receptor activity
VAA049_RS11585	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VAA049_RS11590	COG0545	Peptidyl-prolyl cis-trans isomerase
VAA049_RS11595	COG2885	chlorophyll binding
VAA049_RS11605	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
VAA049_RS11610	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VAA049_RS11615	COG1621	beta-fructofuranosidase activity
VAA049_RS11620	COG1609	Transcriptional regulator
VAA049_RS11625	COG1263	PTS System
VAA049_RS11625	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VAA049_RS11670	COG0446	pyridine nucleotide-disulphide oxidoreductase
VAA049_RS11710	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
VAA049_RS11715	COG0583	DNA-binding transcription factor activity
VAA049_RS11740	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VAA049_RS11770	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VAA049_RS11785	COG2390	Transcriptional regulator
VAA049_RS11795	COG2897	thiosulfate sulfurtransferase activity
VAA049_RS11805	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VAA049_RS11815	COG0302	gtp cyclohydrolase
VAA049_RS11820	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VAA049_RS11820	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VAA049_RS11825	COG2759	Belongs to the formate--tetrahydrofolate ligase family
VAA049_RS11830	COG1970	mechanosensitive ion channel activity
VAA049_RS11835	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
VAA049_RS11845	COG1011	Hydrolase
VAA049_RS11850	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VAA049_RS11855	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VAA049_RS11860	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
VAA049_RS11865	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
VAA049_RS11875	COG3842	ATPase activity
VAA049_RS11895	COG3104	oligopeptide transport
VAA049_RS11920	COG4166	transmembrane transport
VAA049_RS11925	COG4174	ABC transporter (Permease)
VAA049_RS11930	COG4239	(ABC) transporter, permease
VAA049_RS11935	COG4172	Belongs to the ABC transporter superfamily
VAA049_RS11940	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
VAA049_RS11955	COG0625	glutathione transferase activity
VAA049_RS11975	COG2050	protein possibly involved in aromatic compounds catabolism
VAA049_RS11990	COG4771	TonB-dependent receptor
VAA049_RS11990	COG1629	transport
VAA049_RS11995	COG0583	DNA-binding transcription factor activity
VAA049_RS12000	COG0045	succinate-CoA ligase (ADP-forming) activity
VAA049_RS12000	COG1042	CoA-binding domain protein
VAA049_RS12000	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VAA049_RS12020	COG0023	Translation Initiation Factor
VAA049_RS12080	COG3140	Belongs to the UPF0181 family
VAA049_RS12095	COG0745	RESPONSE REGULATOR receiver
VAA049_RS12105	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
VAA049_RS12110	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
VAA049_RS12125	COG3706	GGDEF domain
VAA049_RS12145	COG2199	diguanylate cyclase activity
VAA049_RS12175	COG2824	Alkylphosphonate utilization operon protein PhnA
VAA049_RS12190	COG0737	Belongs to the 5'-nucleotidase family
VAA049_RS12195	COG3593	DNA synthesis involved in DNA repair
VAA049_RS12205	COG0583	DNA-binding transcription factor activity
VAA049_RS12210	COG2116	formate transmembrane transporter activity
VAA049_RS12220	COG3038	cytochrome b561
VAA049_RS12230	COG2200	EAL domain
VAA049_RS12240	COG0586	Pfam SNARE associated Golgi protein
VAA049_RS12245	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VAA049_RS12250	COG0745	RESPONSE REGULATOR receiver
VAA049_RS12255	COG2205	protein histidine kinase activity
VAA049_RS12260	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
VAA049_RS12260	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
VAA049_RS12260	COG0674	pyruvate-flavodoxin oxidoreductase activity
VAA049_RS12260	COG1013	pyruvate-flavodoxin oxidoreductase activity
VAA049_RS12265	COG3158	transport of potassium into the cell
VAA049_RS12275	COG0523	cobalamin synthesis protein
VAA049_RS12280	COG0038	chloride channel
VAA049_RS12290	COG0156	8-amino-7-oxononanoate synthase activity
VAA049_RS12295	COG2205	protein histidine kinase activity
VAA049_RS12295	COG0784	Response regulator, receiver
VAA049_RS12300	COG0419	ATPase involved in DNA repair
VAA049_RS12305	COG0420	3'-5' exonuclease activity
VAA049_RS12310	COG1609	Transcriptional regulator
VAA049_RS12315	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VAA049_RS12315	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
VAA049_RS12320	COG1105	Belongs to the carbohydrate kinase PfkB family
VAA049_RS12325	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
VAA049_RS12325	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VAA049_RS12325	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VAA049_RS12330	COG4067	protein conserved in archaea
VAA049_RS12330	COG0189	ligase activity
VAA049_RS12340	COG0602	queuosine metabolic process
VAA049_RS12345	COG1328	CTP reductase activity
VAA049_RS12355	COG2801	Transposase and inactivated derivatives
VAA049_RS12370	COG5642	Protein of unknown function (DUF2384)
VAA049_RS12410	COG4977	sequence-specific DNA binding
VAA049_RS12435	COG1619	proteins homologs of microcin C7 resistance protein MccF
VAA049_RS12475	COG2801	Transposase and inactivated derivatives
VAA049_RS12570	COG0110	maltose O-acetyltransferase activity
VAA049_RS12600	COG0456	acetyltransferase
VAA049_RS12610	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VAA049_RS12625	COG0384	phenazine biosynthesis protein PhzF
VAA049_RS12680	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VAA049_RS12705	COG2801	Transposase and inactivated derivatives
VAA049_RS12720	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
VAA049_RS12725	COG4139	cobalamin transport
VAA049_RS12730	COG2988	succinylglutamate desuccinylase activity
VAA049_RS12745	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
VAA049_RS12750	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
VAA049_RS12755	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VAA049_RS12760	COG1823	symporter activity
VAA049_RS12765	COG2925	Exonuclease
VAA049_RS12770	COG1380	Effector of murein hydrolase LrgA
VAA049_RS12775	COG1346	cytolysis
VAA049_RS12815	COG0776	regulation of translation
VAA049_RS12820	COG0072	phenylalanine-tRNA ligase activity
VAA049_RS12820	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VAA049_RS12825	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
VAA049_RS12865	COG0322	excinuclease ABC activity
VAA049_RS12870	COG2197	response regulator
VAA049_RS12875	COG0417	DNA replication proofreading
VAA049_RS12880	COG5001	Diguanylate cyclase
VAA049_RS12890	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VAA049_RS12895	COG3099	Belongs to the UPF0263 family
VAA049_RS12910	COG1228	amidohydrolase
VAA049_RS12915	COG0010	Belongs to the arginase family
VAA049_RS12920	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
VAA049_RS12925	COG2986	histidine ammonia-lyase
VAA049_RS12945	COG0247	lactate metabolic process
VAA049_RS12945	COG0277	FAD linked oxidase domain protein
VAA049_RS12960	COG2885	chlorophyll binding
VAA049_RS12980	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
VAA049_RS12990	COG0281	malic enzyme
VAA049_RS13000	COG2949	membrane
VAA049_RS13005	COG3706	GGDEF domain
VAA049_RS13010	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VAA049_RS13020	COG0492	ferredoxin-NADP+ reductase activity
VAA049_RS13025	COG4988	ABC transporter
VAA049_RS13030	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
VAA049_RS13035	COG1187	pseudouridine synthase activity
VAA049_RS13040	COG0009	L-threonylcarbamoyladenylate synthase
VAA049_RS13045	COG0613	PHP domain protein
VAA049_RS13055	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VAA049_RS13060	COG0512	Glutamine amidotransferase of anthranilate synthase
VAA049_RS13065	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
VAA049_RS13070	COG0135	phosphoribosylanthranilate isomerase activity
VAA049_RS13070	COG0134	indole-3-glycerol-phosphate synthase activity
VAA049_RS13075	COG0133	tryptophan synthase activity
VAA049_RS13080	COG0159	tryptophan synthase activity
VAA049_RS13090	COG1435	thymidine kinase activity
VAA049_RS13095	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
VAA049_RS13100	COG1801	Protein of unknown function DUF72
VAA049_RS13105	COG4106	trans-aconitate 2-methyltransferase activity
VAA049_RS13110	COG0500	methyltransferase
VAA049_RS13115	COG4067	protein conserved in archaea
VAA049_RS13115	COG0189	ligase activity
VAA049_RS13130	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
VAA049_RS13140	COG3852	Histidine kinase
VAA049_RS13155	COG3070	regulator of competence-specific genes
VAA049_RS13165	COG2431	L-lysine efflux transmembrane transporter activity
VAA049_RS13175	COG0076	glutamate decarboxylase activity
VAA049_RS13180	COG1737	Transcriptional regulator
VAA049_RS13185	COG1454	alcohol dehydrogenase
VAA049_RS13185	COG1012	belongs to the aldehyde dehydrogenase family
VAA049_RS13190	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VAA049_RS13195	COG2985	domain, Protein
VAA049_RS13195	COG3273	potassium ion transport
VAA049_RS13200	COG0542	response to heat
VAA049_RS13205	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
VAA049_RS13210	COG1278	Cold shock
VAA049_RS13220	COG1187	pseudouridine synthase activity
VAA049_RS13225	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
VAA049_RS13225	COG0140	phosphoribosyl-ATP diphosphatase activity
VAA049_RS13230	COG0107	imidazoleglycerol-phosphate synthase activity
VAA049_RS13235	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
VAA049_RS13240	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
VAA049_RS13245	COG0131	Imidazoleglycerol-phosphate dehydratase
VAA049_RS13245	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VAA049_RS13250	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VAA049_RS13255	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
VAA049_RS13260	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
VAA049_RS13265	COG1757	Na H antiporter
VAA049_RS13270	COG2916	Histone family protein nucleoid-structuring protein H-NS
VAA049_RS13275	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VAA049_RS13280	COG0482	sulfurtransferase activity
VAA049_RS13285	COG2915	High frequency lysogenization protein hflD homolog
VAA049_RS13290	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
VAA049_RS13300	COG2268	Band 7 protein
VAA049_RS13310	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
VAA049_RS13325	COG0300	oxidoreductase activity
VAA049_RS13335	COG0501	Belongs to the peptidase M48B family
VAA049_RS13345	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
VAA049_RS13350	COG2226	methyltransferase
VAA049_RS13355	COG0156	8-amino-7-oxononanoate synthase activity
VAA049_RS13360	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
VAA049_RS13365	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
VAA049_RS13370	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
VAA049_RS13375	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
VAA049_RS13380	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
VAA049_RS13385	COG0653	protein targeting
VAA049_RS13390	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VAA049_RS13395	COG3706	GGDEF domain
VAA049_RS13405	COG4120	Belongs to the binding-protein-dependent transport system permease family
VAA049_RS13415	COG4628	conserved protein (DUF2132)
VAA049_RS13420	COG3092	negative regulation of chromosome organization
VAA049_RS13425	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
VAA049_RS13430	COG0857	belongs to the CobB CobQ family
VAA049_RS13430	COG0280	phosphate acetyltransferase
VAA049_RS13435	COG0435	Glutathione S-transferase
VAA049_RS13445	COG0444	Belongs to the ABC transporter superfamily
VAA049_RS13450	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VAA049_RS13455	COG0601	transmembrane transport
VAA049_RS13475	COG2204	response regulator
VAA049_RS13480	COG3300	MHYT domain
VAA049_RS13480	COG5001	Diguanylate cyclase
VAA049_RS13485	COG4191	Histidine kinase
VAA049_RS13490	COG5002	protein histidine kinase activity
VAA049_RS13500	COG2201	protein-glutamate methylesterase activity
VAA049_RS13515	COG0009	L-threonylcarbamoyladenylate synthase
VAA049_RS13535	COG1881	PFAM PEBP family protein
VAA049_RS13560	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VAA049_RS13565	COG0640	Transcriptional regulator
VAA049_RS13570	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VAA049_RS13575	COG0569	domain protein
VAA049_RS13585	COG0745	RESPONSE REGULATOR receiver
VAA049_RS13590	COG2205	protein histidine kinase activity
VAA049_RS13605	COG2801	Transposase and inactivated derivatives
VAA049_RS13615	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
VAA049_RS13650	COG3706	GGDEF domain
VAA049_RS13670	COG1946	Acyl-CoA thioesterase
VAA049_RS13675	COG1522	sequence-specific DNA binding
VAA049_RS13685	COG0616	signal peptide processing
VAA049_RS13690	COG1028	Short-chain dehydrogenase reductase Sdr
VAA049_RS13695	COG2983	Belongs to the UPF0260 family
VAA049_RS13705	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
VAA049_RS13710	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
VAA049_RS13720	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
VAA049_RS13725	COG2832	Protein of unknown function (DUF454)
VAA049_RS13735	COG0745	RESPONSE REGULATOR receiver
VAA049_RS13740	COG0583	DNA-binding transcription factor activity
VAA049_RS13745	COG0778	Nitroreductase
VAA049_RS13750	COG1250	3-hydroxyacyl-CoA dehydrogenase
VAA049_RS13750	COG1024	Enoyl-CoA hydratase
VAA049_RS13755	COG0183	Belongs to the thiolase family
VAA049_RS13770	COG2067	long-chain fatty acid transport protein
VAA049_RS13780	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VAA049_RS13785	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
VAA049_RS13795	COG2982	Protein involved in outer membrane biogenesis
VAA049_RS13800	COG0572	uridine kinase
VAA049_RS13810	COG0489	protein tyrosine kinase activity
VAA049_RS13815	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VAA049_RS13815	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VAA049_RS13825	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
VAA049_RS13840	COG0517	IMP dehydrogenase activity
VAA049_RS13840	COG0617	tRNA 3'-terminal CCA addition
VAA049_RS13840	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
VAA049_RS13845	COG2199	diguanylate cyclase activity
VAA049_RS13850	COG0314	molybdopterin synthase activity
VAA049_RS13855	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
VAA049_RS13860	COG0315	cyclic pyranopterin monophosphate synthase activity
VAA049_RS13865	COG0521	Mo-molybdopterin cofactor biosynthetic process
VAA049_RS13870	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
VAA049_RS13875	COG0391	Required for morphogenesis under gluconeogenic growth conditions
VAA049_RS13880	COG2198	Histidine kinase
VAA049_RS13885	COG2204	response regulator
VAA049_RS13895	COG0556	nucleotide-excision repair
VAA049_RS13905	COG4657	Part of a membrane complex involved in electron transport
VAA049_RS13910	COG2878	Part of a membrane complex involved in electron transport
VAA049_RS13915	COG4656	Part of a membrane complex involved in electron transport
VAA049_RS13930	COG4660	Part of a membrane complex involved in electron transport
VAA049_RS13935	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
VAA049_RS13940	COG0346	lactoylglutathione lyase activity
VAA049_RS13960	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
VAA049_RS13965	COG2056	Na+-H+ antiporter family
VAA049_RS13970	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
VAA049_RS13975	COG1286	toxin biosynthetic process
VAA049_RS13980	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
VAA049_RS13985	COG0285	dihydrofolate synthase activity
VAA049_RS13990	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
VAA049_RS13995	COG0101	tRNA pseudouridine synthase activity
VAA049_RS14010	COG1263	PTS System
VAA049_RS14010	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VAA049_RS14010	COG2190	(PTS) system
VAA049_RS14015	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
VAA049_RS14020	COG1846	Transcriptional regulator
VAA049_RS14020	COG1940	carbohydrate kinase activity
VAA049_RS14025	COG4651	solute:proton antiporter activity
VAA049_RS14025	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VAA049_RS14030	COG0367	asparagine synthase
VAA049_RS14045	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
VAA049_RS14050	COG0563	adenylate kinase activity
VAA049_RS14055	COG0326	Molecular chaperone. Has ATPase activity
VAA049_RS14060	COG3710	Transcriptional regulator
VAA049_RS14075	COG0622	Phosphoesterase
VAA049_RS14080	COG1090	epimerase
VAA049_RS14085	COG0300	oxidoreductase activity
VAA049_RS14090	COG3118	belongs to the thioredoxin family
VAA049_RS14095	COG0330	HflC and HflK could
VAA049_RS14100	COG1585	Membrane protein implicated in regulation of membrane protease activity
VAA049_RS14105	COG0789	Transcriptional regulator
VAA049_RS14120	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
VAA049_RS14125	COG3115	cell septum assembly
VAA049_RS14130	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
VAA049_RS14135	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
VAA049_RS14145	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VAA049_RS14155	COG2190	(PTS) system
VAA049_RS14160	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VAA049_RS14165	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VAA049_RS14170	COG1702	phosphate starvation-inducible protein PhoH
VAA049_RS14180	COG4535	Mg2 and Co2 transporter CorC
VAA049_RS14185	COG0815	Transfers the fatty acyl group on membrane lipoproteins
VAA049_RS14190	COG2888	peptidyl-tyrosine sulfation
VAA049_RS14195	COG0495	leucyl-tRNA aminoacylation
VAA049_RS14200	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
VAA049_RS14205	COG1466	dna polymerase III delta subunit
VAA049_RS14210	COG0799	negative regulation of ribosome biogenesis
VAA049_RS14215	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
VAA049_RS14220	COG0768	penicillin binding
VAA049_RS14225	COG0772	Belongs to the SEDS family
VAA049_RS14230	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
VAA049_RS14235	COG1686	Belongs to the peptidase S11 family
VAA049_RS14250	COG2921	Belongs to the UPF0250 family
VAA049_RS14255	COG0321	lipoyl(octanoyl) transferase activity
VAA049_RS14260	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
VAA049_RS14270	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VAA049_RS14295	COG1596	polysaccharide export
VAA049_RS14305	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VAA049_RS14335	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
VAA049_RS14375	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
VAA049_RS14380	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
VAA049_RS14390	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VAA049_RS14420	COG0366	Alpha amylase catalytic
VAA049_RS14425	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VAA049_RS14425	COG1263	PTS System
VAA049_RS14430	COG1609	Transcriptional regulator
VAA049_RS14435	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VAA049_RS14440	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
VAA049_RS14445	COG2011	ABC-type metal ion transport system permease component
VAA049_RS14450	COG1464	Belongs to the NlpA lipoprotein family
VAA049_RS14455	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
VAA049_RS14465	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VAA049_RS14465	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VAA049_RS14480	COG1611	Belongs to the LOG family
VAA049_RS14485	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VAA049_RS14495	COG0583	DNA-binding transcription factor activity
VAA049_RS14505	COG0301	tRNA thio-modification
VAA049_RS14505	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VAA049_RS14515	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
VAA049_RS14520	COG1722	exodeoxyribonuclease VII activity
VAA049_RS14525	COG0142	geranyltranstransferase activity
VAA049_RS14530	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
VAA049_RS14535	COG0564	pseudouridine synthase activity
VAA049_RS14540	COG3098	single-species biofilm formation
VAA049_RS14555	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VAA049_RS14565	COG1671	Belongs to the UPF0178 family
VAA049_RS14570	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
VAA049_RS14575	COG0257	Belongs to the bacterial ribosomal protein bL36 family
VAA049_RS14580	COG0254	rRNA binding
VAA049_RS14585	COG1720	tRNA m6t6A37 methyltransferase activity
VAA049_RS14590	COG0442	prolyl-tRNA aminoacylation
VAA049_RS14615	COG0047	phosphoribosylformylglycinamidine synthase activity
VAA049_RS14615	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
VAA049_RS14625	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
VAA049_RS14640	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
VAA049_RS14675	COG0484	heat shock protein binding
VAA049_RS14680	COG0443	Heat shock 70 kDa protein
VAA049_RS14685	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
VAA049_RS14690	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
VAA049_RS14695	COG0497	DNA recombination
VAA049_RS14700	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VAA049_RS14705	COG2914	Belongs to the UPF0125 (RnfH) family
VAA049_RS14710	COG2867	negative regulation of translational initiation
VAA049_RS14715	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
VAA049_RS14720	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
VAA049_RS14725	COG0732	type I restriction modification DNA specificity domain
VAA049_RS14730	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
VAA049_RS14745	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
VAA049_RS14750	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
VAA049_RS14755	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VAA049_RS14775	COG3051	citrate lyase alpha subunit
VAA049_RS14780	COG2301	Belongs to the HpcH HpaI aldolase family
VAA049_RS14785	COG3052	prosthetic group binding
VAA049_RS14790	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
VAA049_RS14800	COG3630	sodium ion export across plasma membrane
VAA049_RS14805	COG0511	ligase activity, forming carbon-carbon bonds
VAA049_RS14805	COG5016	pyruvate
VAA049_RS14810	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
VAA049_RS14820	COG4565	transcriptional regulatory protein
VAA049_RS14835	COG0583	DNA-binding transcription factor activity
VAA049_RS14845	COG1115	amino acid carrier protein
VAA049_RS14850	COG2015	COG2015, Alkyl sulfatase and related hydrolases
VAA049_RS14855	COG0583	DNA-binding transcription factor activity
VAA049_RS14865	COG1120	ATPase activity
VAA049_RS14870	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VAA049_RS14875	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VAA049_RS14880	COG4592	Periplasmic binding protein
VAA049_RS14890	COG1028	Short-chain dehydrogenase reductase Sdr
VAA049_RS14895	COG1169	isochorismate synthase
VAA049_RS14900	COG1021	2,3-dihydroxybenzoate-AMP ligase
VAA049_RS14905	COG1535	isochorismatase
VAA049_RS14905	COG3433	isochorismatase activity
VAA049_RS14910	COG1584	GPR1 FUN34 yaaH family protein
VAA049_RS14920	COG0518	GMP synthase (glutamine-hydrolyzing) activity
VAA049_RS14920	COG0519	Catalyzes the synthesis of GMP from XMP
VAA049_RS14925	COG0517	IMP dehydrogenase activity
VAA049_RS14925	COG0516	GMP reductase activity
VAA049_RS14930	COG1570	exodeoxyribonuclease VII activity
VAA049_RS14945	COG1160	GTP binding
VAA049_RS14950	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VAA049_RS14955	COG2976	Protein conserved in bacteria
VAA049_RS14960	COG0124	histidyl-tRNA synthetase
VAA049_RS14965	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
VAA049_RS14980	COG0105	UTP biosynthetic process
VAA049_RS14985	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VAA049_RS14990	COG2975	iron-sulfur cluster assembly
VAA049_RS14995	COG0633	Ferredoxin
VAA049_RS15015	COG0822	iron-sulfur transferase activity
VAA049_RS15020	COG1104	cysteine desulfurase activity
VAA049_RS15025	COG1959	2 iron, 2 sulfur cluster binding
VAA049_RS15035	COG0483	inositol monophosphate 1-phosphatase activity
VAA049_RS15040	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VAA049_RS15045	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VAA049_RS15050	COG1862	Preprotein translocase
VAA049_RS15065	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
VAA049_RS15070	COG0517	IMP dehydrogenase activity
VAA049_RS15080	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
VAA049_RS15085	COG0583	DNA-binding transcription factor activity
VAA049_RS15090	COG0450	alkyl hydroperoxide reductase
VAA049_RS15095	COG3142	Participates in the control of copper homeostasis
VAA049_RS15110	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VAA049_RS15115	COG0581	inorganic phosphate transmembrane transporter activity
VAA049_RS15125	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
VAA049_RS15130	COG0248	Ppx GppA phosphatase
VAA049_RS15140	COG5002	protein histidine kinase activity
VAA049_RS15145	COG0745	RESPONSE REGULATOR receiver
VAA049_RS15155	COG0826	peptidase U32
VAA049_RS15160	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VAA049_RS15200	COG0542	response to heat
VAA049_RS15210	COG0564	pseudouridine synthase activity
VAA049_RS15215	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VAA049_RS15220	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VAA049_RS15225	COG1605	Chorismate mutase
VAA049_RS15225	COG0077	Prephenate dehydratase
VAA049_RS15230	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VAA049_RS15235	COG5001	Diguanylate cyclase
VAA049_RS15245	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
VAA049_RS15255	COG0488	(ABC) transporter
VAA049_RS15265	COG0287	Prephenate dehydrogenase
VAA049_RS15265	COG1605	Chorismate mutase
VAA049_RS15270	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VAA049_RS15275	COG3275	phosphorelay sensor kinase activity
VAA049_RS15280	COG3279	Response regulator of the LytR AlgR family
VAA049_RS15290	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
VAA049_RS15295	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
VAA049_RS15310	COG1966	Carbon starvation protein
VAA049_RS15315	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
VAA049_RS15320	COG1047	Peptidyl-prolyl cis-trans
VAA049_RS15325	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
VAA049_RS15335	COG0196	riboflavin kinase activity
VAA049_RS15340	COG0728	peptidoglycan biosynthetic process
VAA049_RS15345	COG0268	Binds directly to 16S ribosomal RNA
VAA049_RS15350	COG0640	Transcriptional regulator
VAA049_RS15355	COG0583	DNA-binding transcription factor activity
VAA049_RS15360	COG1283	sodium-dependent phosphate transmembrane transporter activity
VAA049_RS15365	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
VAA049_RS15370	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
VAA049_RS15375	COG0730	response to heat
VAA049_RS15380	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
VAA049_RS15385	COG0494	nUDIX hydrolase
VAA049_RS15395	COG3066	DNA modification
VAA049_RS15400	COG0667	Aldo Keto reductase
VAA049_RS15410	COG2204	response regulator
VAA049_RS15415	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
VAA049_RS15420	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
VAA049_RS15435	COG0513	Belongs to the DEAD box helicase family
VAA049_RS15460	COG3153	acetyltransferase
VAA049_RS15465	COG3154	lipid carrier protein
VAA049_RS15475	COG0826	peptidase U32
VAA049_RS15480	COG0826	peptidase U32
VAA049_RS15510	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
VAA049_RS15520	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
VAA049_RS15525	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
VAA049_RS15530	COG0195	Participates in both transcription termination and antitermination
VAA049_RS15535	COG0779	Required for maturation of 30S ribosomal subunits
VAA049_RS15550	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VAA049_RS15560	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
VAA049_RS15565	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VAA049_RS15570	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
VAA049_RS15575	COG1534	Rna-binding protein
VAA049_RS15580	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VAA049_RS15585	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
VAA049_RS15590	COG2027	D-alanyl-D-alanine carboxypeptidase
VAA049_RS15595	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VAA049_RS15600	COG0739	heme binding
VAA049_RS15615	COG0316	Belongs to the HesB IscA family
VAA049_RS15620	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
VAA049_RS15630	COG0628	permease
VAA049_RS15635	COG2813	Specifically methylates the guanine in position
VAA049_RS15640	COG2205	protein histidine kinase activity
VAA049_RS15640	COG0784	Response regulator, receiver
VAA049_RS15650	COG0747	negative chemotaxis
VAA049_RS15655	COG0601	transmembrane transport
VAA049_RS15660	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VAA049_RS15665	COG0444	Belongs to the ABC transporter superfamily
VAA049_RS15670	COG4608	Belongs to the ABC transporter superfamily
VAA049_RS15680	COG2971	BadF BadG BcrA BcrD
VAA049_RS15700	COG3842	ATPase activity
VAA049_RS15710	COG1840	ABC-type Fe3 transport system, periplasmic component
VAA049_RS15715	COG0004	ammonium transporteR
VAA049_RS15720	COG0347	Belongs to the P(II) protein family
VAA049_RS15725	COG3112	Uncharacterised protein family (UPF0231)
VAA049_RS15730	COG1049	propionate catabolic process, 2-methylcitrate cycle
VAA049_RS15735	COG1752	Esterase of the alpha-beta hydrolase superfamily
VAA049_RS15740	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VAA049_RS15745	COG1643	Atp-dependent helicase
VAA049_RS15755	COG1489	DNA binding
VAA049_RS15765	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VAA049_RS15775	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VAA049_RS15780	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
VAA049_RS15785	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
VAA049_RS15790	COG0842	Transport permease protein
VAA049_RS15795	COG1131	(ABC) transporter
VAA049_RS15800	COG0659	secondary active sulfate transmembrane transporter activity
VAA049_RS15805	COG0288	reversible hydration of carbon dioxide
VAA049_RS15820	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
VAA049_RS15825	COG3107	peptidoglycan biosynthetic process
VAA049_RS15830	COG0792	nuclease activity
VAA049_RS15835	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VAA049_RS15840	COG2823	Periplasmic or secreted lipoprotein
VAA049_RS15845	COG2969	positive regulation of protein catabolic process
VAA049_RS15850	COG0625	glutathione transferase activity
VAA049_RS15855	COG2857	Cytochrome c1
VAA049_RS15860	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
VAA049_RS15865	COG0723	plastoquinol--plastocyanin reductase activity
VAA049_RS15870	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
VAA049_RS15875	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
VAA049_RS15885	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
VAA049_RS15895	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VAA049_RS15900	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VAA049_RS15905	COG0335	large ribosomal subunit rRNA binding
VAA049_RS15910	COG0336	Belongs to the RNA methyltransferase TrmD family
VAA049_RS15915	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
VAA049_RS15920	COG0228	four-way junction DNA binding
VAA049_RS15925	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
VAA049_RS15930	COG4137	Cytochrome C assembly protein
VAA049_RS15935	COG4536	flavin adenine dinucleotide binding
VAA049_RS15940	COG1854	S-ribosylhomocysteine lyase activity
VAA049_RS15945	COG2918	glutathione biosynthetic process
VAA049_RS15950	COG0612	Peptidase, M16
VAA049_RS15955	COG1238	metal cluster binding
VAA049_RS15965	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
VAA049_RS15970	COG5016	pyruvate
VAA049_RS15970	COG0511	ligase activity, forming carbon-carbon bonds
VAA049_RS15975	COG3630	sodium ion export across plasma membrane
VAA049_RS16025	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
VAA049_RS16030	COG0527	aspartate kinase activity
VAA049_RS16035	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
VAA049_RS16040	COG2137	regulation of response to DNA damage stimulus
VAA049_RS16045	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
VAA049_RS16055	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
VAA049_RS16060	COG4208	sulfate ABC transporter
VAA049_RS16080	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
VAA049_RS16085	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VAA049_RS16095	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
VAA049_RS16100	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
VAA049_RS16105	COG0585	pseudouridine synthase activity
VAA049_RS16110	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
VAA049_RS16115	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
VAA049_RS16120	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
VAA049_RS16125	COG1968	undecaprenyl-diphosphatase activity
VAA049_RS16130	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VAA049_RS16135	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
VAA049_RS16140	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
VAA049_RS16150	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
VAA049_RS16155	COG0828	Belongs to the bacterial ribosomal protein bS21 family
VAA049_RS16160	COG1610	YqeY-like protein
VAA049_RS16165	COG0358	DNA primase activity
VAA049_RS16185	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
VAA049_RS16190	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
VAA049_RS16195	COG1349	DNA-binding transcription factor activity
VAA049_RS16215	COG1279	arginine transmembrane transporter activity
VAA049_RS16220	COG0668	transmembrane transport
VAA049_RS16230	COG0191	fructose-bisphosphate aldolase activity
VAA049_RS16235	COG0126	phosphoglycerate kinase activity
VAA049_RS16240	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VAA049_RS16245	COG4771	TonB-dependent receptor
VAA049_RS16250	COG0583	DNA-binding transcription factor activity
VAA049_RS16255	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VAA049_RS16265	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
VAA049_RS16270	COG3091	SprT-like family
VAA049_RS16275	COG2356	endonuclease I
VAA049_RS16280	COG1385	rRNA (uridine-N3-)-methyltransferase activity
VAA049_RS16285	COG0189	ligase activity
VAA049_RS16290	COG1678	Uncharacterized ACR, COG1678
VAA049_RS16295	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
VAA049_RS16300	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VAA049_RS16320	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
VAA049_RS16325	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
VAA049_RS16330	COG0762	integral membrane protein
VAA049_RS16345	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
VAA049_RS16350	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VAA049_RS16355	COG2066	Belongs to the glutaminase family
VAA049_RS16360	COG0220	tRNA (guanine-N7-)-methyltransferase activity
VAA049_RS16365	COG1194	a g-specific adenine glycosylase
VAA049_RS16370	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
VAA049_RS16375	COG0741	lytic transglycosylase activity
VAA049_RS16430	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
VAA049_RS16435	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
VAA049_RS16440	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VAA049_RS16445	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
VAA049_RS16450	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
VAA049_RS16455	COG2967	ApaG domain
VAA049_RS16460	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
VAA049_RS16470	COG3610	response to peptide
VAA049_RS16475	COG2966	Psort location CytoplasmicMembrane, score
VAA049_RS16480	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
VAA049_RS16485	COG0211	Belongs to the bacterial ribosomal protein bL27 family
VAA049_RS16490	COG0261	This protein binds to 23S rRNA in the presence of protein L20
VAA049_RS16495	COG0142	geranyltranstransferase activity
VAA049_RS16500	COG0531	amino acid
VAA049_RS16505	COG0039	L-malate dehydrogenase activity
VAA049_RS16510	COG1438	arginine binding
VAA049_RS16515	COG2358	TRAP transporter, solute receptor (TAXI family
VAA049_RS16525	COG0589	response to stress
VAA049_RS16545	COG2235	arginine
VAA049_RS16550	COG0312	modulator of DNA gyrase
VAA049_RS16555	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VAA049_RS16560	COG3164	Protein of unknown function
VAA049_RS16570	COG0424	maF-like protein
VAA049_RS16575	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
VAA049_RS16580	COG1792	Involved in formation and maintenance of cell shape
VAA049_RS16585	COG1077	Cell shape determining protein MreB Mrl
VAA049_RS16615	COG2165	general secretion pathway protein
VAA049_RS16620	COG2165	general secretion pathway protein
VAA049_RS16630	COG1459	type II secretion system
VAA049_RS16645	COG3409	Peptidoglycan-binding domain 1 protein
VAA049_RS16645	COG3267	Type II secretory pathway component ExeA
VAA049_RS16670	COG2200	EAL domain
VAA049_RS16670	COG2199	diguanylate cyclase activity
VAA049_RS16675	COG0629	single-stranded DNA binding
VAA049_RS16690	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
VAA049_RS16700	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
VAA049_RS16705	COG0527	aspartate kinase activity
VAA049_RS16715	COG0646	methionine synthase
VAA049_RS16715	COG1410	methionine synthase
VAA049_RS16790	COG0175	sulfate reduction
VAA049_RS16795	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VAA049_RS16800	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VAA049_RS16825	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VAA049_RS16830	COG0735	belongs to the Fur family
VAA049_RS16845	COG0166	Belongs to the GPI family
VAA049_RS16850	COG0432	Pfam Uncharacterised protein family UPF0047
VAA049_RS16855	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VAA049_RS16870	COG0359	binds to the 23S rRNA
VAA049_RS16875	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
VAA049_RS16880	COG2965	DNA replication, synthesis of RNA primer
VAA049_RS16885	COG0360	Binds together with S18 to 16S ribosomal RNA
VAA049_RS16895	COG2906	2 iron, 2 sulfur cluster binding
VAA049_RS16900	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VAA049_RS16905	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VAA049_RS16910	COG0049	tRNA binding
VAA049_RS16925	COG2923	Belongs to the DsrF TusC family
VAA049_RS16930	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
VAA049_RS16935	COG2964	Protein conserved in bacteria
VAA049_RS16940	COG0545	Peptidyl-prolyl cis-trans isomerase
VAA049_RS16950	COG2900	Belongs to the SlyX family
VAA049_RS16955	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
VAA049_RS16960	COG0330	HflC and HflK could
VAA049_RS16965	COG0330	HflC and HflK could
VAA049_RS16970	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
VAA049_RS16975	COG1923	regulation of RNA biosynthetic process
VAA049_RS16980	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
VAA049_RS16985	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
VAA049_RS16995	COG0802	atpase or kinase
VAA049_RS17000	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
VAA049_RS17050	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
VAA049_RS17055	COG1162	GTPase activity
VAA049_RS17060	COG0688	phosphatidylethanolamine metabolic process
VAA049_RS17065	COG0471	metal ion transport
VAA049_RS17075	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
VAA049_RS17080	COG4942	peptidase
VAA049_RS17095	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
VAA049_RS17100	COG2816	NAD+ diphosphatase activity
VAA049_RS17105	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
VAA049_RS17110	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
VAA049_RS17115	COG0085	RNA polymerase activity
VAA049_RS17120	COG0222	ribosome binding
VAA049_RS17125	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
VAA049_RS17135	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
VAA049_RS17140	COG0250	Participates in transcription elongation, termination and antitermination
VAA049_RS17145	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VAA049_RS17150	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VAA049_RS17175	COG1072	(Pantothenic acid kinase))
VAA049_RS17185	COG0812	UDP-N-acetylmuramate dehydrogenase activity
VAA049_RS17200	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VAA049_RS17245	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
VAA049_RS17260	COG3118	belongs to the thioredoxin family
VAA049_RS17265	COG0513	Belongs to the DEAD box helicase family
VAA049_RS17270	COG0248	Ppx GppA phosphatase
VAA049_RS17275	COG0784	Response regulator, receiver
VAA049_RS17275	COG2205	protein histidine kinase activity
VAA049_RS17280	COG2814	Major facilitator Superfamily
VAA049_RS17300	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VAA049_RS17305	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
VAA049_RS17310	COG0511	ligase activity, forming carbon-carbon bonds
VAA049_RS17315	COG0439	Biotin carboxylase
VAA049_RS17320	COG2264	protein methyltransferase activity
VAA049_RS17325	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VAA049_RS17330	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
VAA049_RS17340	COG1609	Transcriptional regulator
VAA049_RS17345	COG0129	dihydroxy-acid dehydratase activity
VAA049_RS17350	COG3265	gluconokinase activity
VAA049_RS17355	COG2610	gluconate transmembrane transporter activity
VAA049_RS17360	COG0800	Aldolase
VAA049_RS17375	COG0840	transmembrane signaling receptor activity
VAA049_RS17380	COG1982	Orn Lys Arg decarboxylase major
VAA049_RS17385	COG0531	amino acid
VAA049_RS17390	COG3710	Transcriptional regulator
VAA049_RS17395	COG0789	Transcriptional regulator
VAA049_RS17410	COG0151	Belongs to the GarS family
VAA049_RS17420	COG0776	regulation of translation
VAA049_RS17430	COG1253	flavin adenine dinucleotide binding
VAA049_RS17435	COG1940	carbohydrate kinase activity
VAA049_RS17445	COG3068	Protein conserved in bacteria
VAA049_RS17455	COG1573	uracil-dna glycosylase
VAA049_RS17460	COG0668	transmembrane transport
VAA049_RS17475	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
VAA049_RS17480	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VAA049_RS17505	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VAA049_RS17510	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
VAA049_RS17520	COG0463	Glycosyl transferase, family 2
VAA049_RS17535	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
VAA049_RS17540	COG0318	PFAM AMP-dependent synthetase and ligase
VAA049_RS17555	COG1028	Short-chain dehydrogenase reductase Sdr
VAA049_RS17565	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VAA049_RS17580	COG1088	dTDP-glucose 4,6-dehydratase activity
VAA049_RS17610	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VAA049_RS17615	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
VAA049_RS17615	COG0662	Cupin 2, conserved barrel domain protein
VAA049_RS17620	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VAA049_RS17655	COG1519	Transferase
VAA049_RS17685	COG3642	lipopolysaccharide core region biosynthetic process
VAA049_RS17690	COG0859	PFAM glycosyl transferase family 9
VAA049_RS17695	COG0463	Glycosyl transferase, family 2
VAA049_RS17700	COG0859	PFAM glycosyl transferase family 9
VAA049_RS17705	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
VAA049_RS17710	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
VAA049_RS17720	COG0267	Belongs to the bacterial ribosomal protein bL33 family
VAA049_RS17725	COG0227	Belongs to the bacterial ribosomal protein bL28 family
VAA049_RS17730	COG2003	Belongs to the UPF0758 family
VAA049_RS17740	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
VAA049_RS17745	COG1309	transcriptional regulator
VAA049_RS17750	COG1560	Kdo2-lipid A biosynthetic process
VAA049_RS17755	COG1560	Kdo2-lipid A biosynthetic process
VAA049_RS17760	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
VAA049_RS17765	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
VAA049_RS17770	COG1561	YicC-like family, N-terminal region
VAA049_RS17775	COG2862	Uncharacterized protein family, UPF0114
VAA049_RS17780	COG1263	PTS System
VAA049_RS17780	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VAA049_RS17785	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
VAA049_RS17805	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VAA049_RS17810	COG1120	ATPase activity
VAA049_RS17815	COG4774	siderophore transport
VAA049_RS17820	COG1132	(ABC) transporter
VAA049_RS17835	COG0514	ATP-dependent DNA helicase (RecQ)
VAA049_RS17840	COG2962	Rard protein
VAA049_RS17845	COG0405	Gamma-glutamyltransferase
VAA049_RS17855	COG1280	lysine exporter protein (LysE YggA)
VAA049_RS17860	COG0210	DNA helicase
VAA049_RS17870	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
VAA049_RS17875	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VAA049_RS17885	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VAA049_RS17890	COG0601	transmembrane transport
VAA049_RS17895	COG0747	negative chemotaxis
VAA049_RS17950	COG1309	transcriptional regulator
VAA049_RS17955	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VAA049_RS17960	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VAA049_RS17965	COG2960	long-chain fatty acid transporting porin activity
VAA049_RS17970	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
VAA049_RS17975	COG0583	DNA-binding transcription factor activity
VAA049_RS18045	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
VAA049_RS18050	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VAA049_RS18055	COG1739	Uncharacterized protein family UPF0029
VAA049_RS18060	COG1024	Enoyl-CoA hydratase
VAA049_RS18060	COG1250	3-hydroxyacyl-CoA dehydrogenase
VAA049_RS18065	COG0183	Belongs to the thiolase family
VAA049_RS18070	COG0583	DNA-binding transcription factor activity
VAA049_RS18075	COG2814	Major facilitator Superfamily
VAA049_RS18085	COG0355	proton-transporting ATP synthase activity, rotational mechanism
VAA049_RS18090	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
VAA049_RS18095	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
VAA049_RS18100	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
VAA049_RS18105	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
VAA049_RS18110	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
VAA049_RS18120	COG0356	it plays a direct role in the translocation of protons across the membrane
VAA049_RS18125	COG3312	ion transport
VAA049_RS18130	COG1475	DNA binding
VAA049_RS18135	COG1192	Involved in chromosome partitioning
VAA049_RS18140	COG0357	Ribosomal RNA small subunit methyltransferase G
VAA049_RS18145	COG0445	tRNA wobble uridine modification
VAA049_RS18155	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VAA049_RS18160	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
VAA049_RS18165	COG0706	membrane insertase activity
VAA049_RS18175	COG0594	ribonuclease P activity
VAA049_RS18180	COG0230	Belongs to the bacterial ribosomal protein bL34 family
VAA049_RS18185	COG1126	abc transporter atp-binding protein
VAA049_RS18215	COG3646	Phage regulatory protein