locus-tag	class	description
EZZ25_RS00015	COG0366	Alpha amylase catalytic
EZZ25_RS00020	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EZZ25_RS00020	COG1263	PTS System
EZZ25_RS00025	COG1609	Transcriptional regulator
EZZ25_RS00030	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EZZ25_RS00035	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EZZ25_RS00040	COG2011	ABC-type metal ion transport system permease component
EZZ25_RS00045	COG1464	Belongs to the NlpA lipoprotein family
EZZ25_RS00050	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
EZZ25_RS00060	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EZZ25_RS00060	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EZZ25_RS00075	COG1611	Belongs to the LOG family
EZZ25_RS00080	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EZZ25_RS00085	COG2363	Small membrane protein
EZZ25_RS00090	COG0583	DNA-binding transcription factor activity
EZZ25_RS00095	COG0301	tRNA thio-modification
EZZ25_RS00095	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EZZ25_RS00105	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EZZ25_RS00110	COG1722	exodeoxyribonuclease VII activity
EZZ25_RS00115	COG0142	geranyltranstransferase activity
EZZ25_RS00120	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EZZ25_RS00125	COG0564	pseudouridine synthase activity
EZZ25_RS00130	COG3098	single-species biofilm formation
EZZ25_RS00145	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EZZ25_RS00155	COG1671	Belongs to the UPF0178 family
EZZ25_RS00160	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
EZZ25_RS00165	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EZZ25_RS00170	COG0254	rRNA binding
EZZ25_RS00175	COG1720	tRNA m6t6A37 methyltransferase activity
EZZ25_RS00180	COG0442	prolyl-tRNA aminoacylation
EZZ25_RS00200	COG0047	phosphoribosylformylglycinamidine synthase activity
EZZ25_RS00200	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EZZ25_RS00210	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
EZZ25_RS00220	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
EZZ25_RS00245	COG4968	Prepilin-type N-terminal cleavage methylation domain
EZZ25_RS00255	COG0484	heat shock protein binding
EZZ25_RS00260	COG0443	Heat shock 70 kDa protein
EZZ25_RS00265	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EZZ25_RS00270	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EZZ25_RS00275	COG0497	DNA recombination
EZZ25_RS00280	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EZZ25_RS00285	COG2914	Belongs to the UPF0125 (RnfH) family
EZZ25_RS00290	COG2867	negative regulation of translational initiation
EZZ25_RS00295	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EZZ25_RS00305	COG0582	viral genome integration into host DNA
EZZ25_RS00315	COG1401	restriction endodeoxyribonuclease activity
EZZ25_RS00325	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EZZ25_RS00330	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EZZ25_RS00355	COG2003	Belongs to the UPF0758 family
EZZ25_RS00430	COG1061	Type III restriction enzyme res subunit
EZZ25_RS00445	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
EZZ25_RS00450	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
EZZ25_RS00455	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EZZ25_RS00475	COG3051	citrate lyase alpha subunit
EZZ25_RS00480	COG2301	Belongs to the HpcH HpaI aldolase family
EZZ25_RS00485	COG3052	prosthetic group binding
EZZ25_RS00490	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
EZZ25_RS00505	COG0511	ligase activity, forming carbon-carbon bonds
EZZ25_RS00505	COG5016	pyruvate
EZZ25_RS00510	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
EZZ25_RS00520	COG4565	transcriptional regulatory protein
EZZ25_RS00535	COG0583	DNA-binding transcription factor activity
EZZ25_RS00545	COG1115	amino acid carrier protein
EZZ25_RS00550	COG2015	COG2015, Alkyl sulfatase and related hydrolases
EZZ25_RS00555	COG0583	DNA-binding transcription factor activity
EZZ25_RS00565	COG1120	ATPase activity
EZZ25_RS00570	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EZZ25_RS00575	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EZZ25_RS00580	COG4592	Periplasmic binding protein
EZZ25_RS00590	COG1028	Short-chain dehydrogenase reductase Sdr
EZZ25_RS00595	COG1169	isochorismate synthase
EZZ25_RS00600	COG1021	2,3-dihydroxybenzoate-AMP ligase
EZZ25_RS00605	COG1535	isochorismatase
EZZ25_RS00605	COG3433	isochorismatase activity
EZZ25_RS00610	COG1584	GPR1 FUN34 yaaH family protein
EZZ25_RS00620	COG0519	Catalyzes the synthesis of GMP from XMP
EZZ25_RS00620	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EZZ25_RS00625	COG0517	IMP dehydrogenase activity
EZZ25_RS00625	COG0516	GMP reductase activity
EZZ25_RS00630	COG1570	exodeoxyribonuclease VII activity
EZZ25_RS00645	COG1160	GTP binding
EZZ25_RS00650	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EZZ25_RS00655	COG2976	Protein conserved in bacteria
EZZ25_RS00660	COG0124	histidyl-tRNA synthetase
EZZ25_RS00665	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EZZ25_RS00680	COG0105	UTP biosynthetic process
EZZ25_RS00685	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EZZ25_RS00690	COG2975	iron-sulfur cluster assembly
EZZ25_RS00695	COG0633	Ferredoxin
EZZ25_RS00700	COG0443	Heat shock 70 kDa protein
EZZ25_RS00715	COG0822	iron-sulfur transferase activity
EZZ25_RS00725	COG1959	2 iron, 2 sulfur cluster binding
EZZ25_RS00735	COG0483	inositol monophosphate 1-phosphatase activity
EZZ25_RS00740	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EZZ25_RS00745	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EZZ25_RS00750	COG1862	Preprotein translocase
EZZ25_RS00765	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EZZ25_RS00770	COG0517	IMP dehydrogenase activity
EZZ25_RS00780	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EZZ25_RS00785	COG0583	DNA-binding transcription factor activity
EZZ25_RS00790	COG0450	alkyl hydroperoxide reductase
EZZ25_RS00795	COG3142	Participates in the control of copper homeostasis
EZZ25_RS00810	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EZZ25_RS00815	COG0581	inorganic phosphate transmembrane transporter activity
EZZ25_RS00825	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EZZ25_RS00830	COG0248	Ppx GppA phosphatase
EZZ25_RS00840	COG5002	protein histidine kinase activity
EZZ25_RS00845	COG0745	RESPONSE REGULATOR receiver
EZZ25_RS00855	COG0826	peptidase U32
EZZ25_RS00860	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EZZ25_RS00900	COG0542	response to heat
EZZ25_RS00910	COG0564	pseudouridine synthase activity
EZZ25_RS00915	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EZZ25_RS00920	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EZZ25_RS00925	COG0077	Prephenate dehydratase
EZZ25_RS00925	COG1605	Chorismate mutase
EZZ25_RS00930	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EZZ25_RS00935	COG5001	Diguanylate cyclase
EZZ25_RS00945	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
EZZ25_RS00955	COG0488	(ABC) transporter
EZZ25_RS00965	COG1605	Chorismate mutase
EZZ25_RS00965	COG0287	Prephenate dehydrogenase
EZZ25_RS00970	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EZZ25_RS00975	COG3275	phosphorelay sensor kinase activity
EZZ25_RS00980	COG3279	Response regulator of the LytR AlgR family
EZZ25_RS00990	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EZZ25_RS00995	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EZZ25_RS01005	COG1966	Carbon starvation protein
EZZ25_RS01010	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EZZ25_RS01015	COG1047	Peptidyl-prolyl cis-trans
EZZ25_RS01020	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EZZ25_RS01030	COG0196	riboflavin kinase activity
EZZ25_RS01035	COG0728	peptidoglycan biosynthetic process
EZZ25_RS01040	COG0268	Binds directly to 16S ribosomal RNA
EZZ25_RS01045	COG0640	Transcriptional regulator
EZZ25_RS01050	COG0583	DNA-binding transcription factor activity
EZZ25_RS01055	COG1283	sodium-dependent phosphate transmembrane transporter activity
EZZ25_RS01065	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EZZ25_RS01070	COG0730	response to heat
EZZ25_RS01075	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
EZZ25_RS01080	COG0494	nUDIX hydrolase
EZZ25_RS01085	COG3066	DNA modification
EZZ25_RS01090	COG0667	Aldo Keto reductase
EZZ25_RS01100	COG2204	response regulator
EZZ25_RS01105	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EZZ25_RS01125	COG0513	Belongs to the DEAD box helicase family
EZZ25_RS01150	COG3153	acetyltransferase
EZZ25_RS01155	COG3154	lipid carrier protein
EZZ25_RS01165	COG0826	peptidase U32
EZZ25_RS01170	COG0826	peptidase U32
EZZ25_RS01190	COG1185	polyribonucleotide nucleotidyltransferase activity
EZZ25_RS01195	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EZZ25_RS01205	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EZZ25_RS01210	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EZZ25_RS01215	COG0195	Participates in both transcription termination and antitermination
EZZ25_RS01220	COG0779	Required for maturation of 30S ribosomal subunits
EZZ25_RS01235	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EZZ25_RS01250	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EZZ25_RS01255	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EZZ25_RS01260	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
EZZ25_RS01265	COG1534	Rna-binding protein
EZZ25_RS01270	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EZZ25_RS01275	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EZZ25_RS01280	COG2027	D-alanyl-D-alanine carboxypeptidase
EZZ25_RS01285	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EZZ25_RS01290	COG0739	heme binding
EZZ25_RS01295	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EZZ25_RS01305	COG0316	Belongs to the HesB IscA family
EZZ25_RS01310	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EZZ25_RS01315	COG0628	permease
EZZ25_RS01320	COG2813	Specifically methylates the guanine in position
EZZ25_RS01325	COG0784	Response regulator, receiver
EZZ25_RS01325	COG2205	protein histidine kinase activity
EZZ25_RS01335	COG0747	negative chemotaxis
EZZ25_RS01340	COG0601	transmembrane transport
EZZ25_RS01345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EZZ25_RS01350	COG0444	Belongs to the ABC transporter superfamily
EZZ25_RS01355	COG4608	Belongs to the ABC transporter superfamily
EZZ25_RS01365	COG2971	BadF BadG BcrA BcrD
EZZ25_RS01385	COG3842	ATPase activity
EZZ25_RS01395	COG1840	ABC-type Fe3 transport system, periplasmic component
EZZ25_RS01400	COG0004	ammonium transporteR
EZZ25_RS01405	COG0347	Belongs to the P(II) protein family
EZZ25_RS01410	COG3112	Uncharacterised protein family (UPF0231)
EZZ25_RS01415	COG1049	propionate catabolic process, 2-methylcitrate cycle
EZZ25_RS01420	COG1752	Esterase of the alpha-beta hydrolase superfamily
EZZ25_RS01425	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EZZ25_RS01430	COG1643	Atp-dependent helicase
EZZ25_RS01440	COG1489	DNA binding
EZZ25_RS01450	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EZZ25_RS01460	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EZZ25_RS01465	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EZZ25_RS01470	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EZZ25_RS01475	COG0842	Transport permease protein
EZZ25_RS01480	COG1131	(ABC) transporter
EZZ25_RS01485	COG0659	secondary active sulfate transmembrane transporter activity
EZZ25_RS01490	COG0288	reversible hydration of carbon dioxide
EZZ25_RS01505	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EZZ25_RS01510	COG3107	peptidoglycan biosynthetic process
EZZ25_RS01515	COG0792	nuclease activity
EZZ25_RS01520	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EZZ25_RS01525	COG2823	Periplasmic or secreted lipoprotein
EZZ25_RS01540	COG2969	positive regulation of protein catabolic process
EZZ25_RS01545	COG0625	glutathione transferase activity
EZZ25_RS01550	COG2857	Cytochrome c1
EZZ25_RS01555	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EZZ25_RS01560	COG0723	plastoquinol--plastocyanin reductase activity
EZZ25_RS01565	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EZZ25_RS01570	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EZZ25_RS01575	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
EZZ25_RS01585	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EZZ25_RS01590	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EZZ25_RS01595	COG0335	large ribosomal subunit rRNA binding
EZZ25_RS01600	COG0336	Belongs to the RNA methyltransferase TrmD family
EZZ25_RS01605	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EZZ25_RS01610	COG0228	four-way junction DNA binding
EZZ25_RS01615	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EZZ25_RS01620	COG4137	Cytochrome C assembly protein
EZZ25_RS01625	COG4536	flavin adenine dinucleotide binding
EZZ25_RS01630	COG1854	S-ribosylhomocysteine lyase activity
EZZ25_RS01635	COG2918	glutathione biosynthetic process
EZZ25_RS01640	COG0612	Peptidase, M16
EZZ25_RS01645	COG1238	metal cluster binding
EZZ25_RS01655	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
EZZ25_RS01660	COG0511	ligase activity, forming carbon-carbon bonds
EZZ25_RS01660	COG5016	pyruvate
EZZ25_RS01665	COG3630	sodium ion export across plasma membrane
EZZ25_RS01710	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
EZZ25_RS01715	COG0527	aspartate kinase activity
EZZ25_RS01720	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EZZ25_RS01725	COG2137	regulation of response to DNA damage stimulus
EZZ25_RS01730	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EZZ25_RS01740	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
EZZ25_RS01745	COG4208	sulfate ABC transporter
EZZ25_RS01765	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EZZ25_RS01770	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EZZ25_RS01780	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EZZ25_RS01785	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
EZZ25_RS01790	COG0585	pseudouridine synthase activity
EZZ25_RS01795	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
EZZ25_RS01800	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EZZ25_RS01805	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
EZZ25_RS01810	COG1968	undecaprenyl-diphosphatase activity
EZZ25_RS01815	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EZZ25_RS01820	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EZZ25_RS01830	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EZZ25_RS01840	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EZZ25_RS01845	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EZZ25_RS01850	COG1610	YqeY-like protein
EZZ25_RS01855	COG0358	DNA primase activity
EZZ25_RS01875	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EZZ25_RS01880	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EZZ25_RS01885	COG1349	DNA-binding transcription factor activity
EZZ25_RS01905	COG1279	arginine transmembrane transporter activity
EZZ25_RS01910	COG0668	transmembrane transport
EZZ25_RS01920	COG0191	fructose-bisphosphate aldolase activity
EZZ25_RS01925	COG0126	phosphoglycerate kinase activity
EZZ25_RS01930	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EZZ25_RS01935	COG4771	TonB-dependent receptor
EZZ25_RS01940	COG0583	DNA-binding transcription factor activity
EZZ25_RS01945	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EZZ25_RS01950	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EZZ25_RS01960	COG2356	endonuclease I
EZZ25_RS01965	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EZZ25_RS01970	COG0189	ligase activity
EZZ25_RS01975	COG1678	Uncharacterized ACR, COG1678
EZZ25_RS01980	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EZZ25_RS01985	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EZZ25_RS02005	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EZZ25_RS02010	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EZZ25_RS02015	COG0762	integral membrane protein
EZZ25_RS02020	COG1872	DUF167
EZZ25_RS02030	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EZZ25_RS02035	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EZZ25_RS02040	COG2066	Belongs to the glutaminase family
EZZ25_RS02045	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EZZ25_RS02050	COG1194	a g-specific adenine glycosylase
EZZ25_RS02055	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
EZZ25_RS02060	COG0741	lytic transglycosylase activity
EZZ25_RS02115	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
EZZ25_RS02120	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
EZZ25_RS02125	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EZZ25_RS02130	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EZZ25_RS02135	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EZZ25_RS02140	COG2967	ApaG domain
EZZ25_RS02145	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EZZ25_RS02160	COG3610	response to peptide
EZZ25_RS02165	COG2966	Psort location CytoplasmicMembrane, score
EZZ25_RS02170	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EZZ25_RS02175	COG0211	Belongs to the bacterial ribosomal protein bL27 family
EZZ25_RS02180	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EZZ25_RS02185	COG0142	geranyltranstransferase activity
EZZ25_RS02190	COG0531	amino acid
EZZ25_RS02195	COG0039	L-malate dehydrogenase activity
EZZ25_RS02200	COG1438	arginine binding
EZZ25_RS02210	COG2358	TRAP transporter, solute receptor (TAXI family
EZZ25_RS02220	COG0589	response to stress
EZZ25_RS02245	COG2235	arginine
EZZ25_RS02250	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EZZ25_RS02255	COG1151	hydroxylamine reductase activity
EZZ25_RS02260	COG0312	modulator of DNA gyrase
EZZ25_RS02265	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EZZ25_RS02270	COG3164	Protein of unknown function
EZZ25_RS02280	COG0424	maF-like protein
EZZ25_RS02285	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
EZZ25_RS02290	COG1792	Involved in formation and maintenance of cell shape
EZZ25_RS02295	COG1077	Cell shape determining protein MreB Mrl
EZZ25_RS02325	COG2165	general secretion pathway protein
EZZ25_RS02330	COG2165	general secretion pathway protein
EZZ25_RS02340	COG1459	type II secretion system
EZZ25_RS02345	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EZZ25_RS02355	COG3409	Peptidoglycan-binding domain 1 protein
EZZ25_RS02355	COG3267	Type II secretory pathway component ExeA
EZZ25_RS02380	COG2199	diguanylate cyclase activity
EZZ25_RS02380	COG2200	EAL domain
EZZ25_RS02385	COG0629	single-stranded DNA binding
EZZ25_RS02400	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EZZ25_RS02410	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EZZ25_RS02415	COG0527	aspartate kinase activity
EZZ25_RS02420	COG1410	methionine synthase
EZZ25_RS02420	COG0646	methionine synthase
EZZ25_RS02490	COG0175	sulfate reduction
EZZ25_RS02500	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EZZ25_RS02525	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EZZ25_RS02530	COG0735	belongs to the Fur family
EZZ25_RS02545	COG0166	Belongs to the GPI family
EZZ25_RS02550	COG0432	Pfam Uncharacterised protein family UPF0047
EZZ25_RS02555	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EZZ25_RS02570	COG0359	binds to the 23S rRNA
EZZ25_RS02575	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
EZZ25_RS02580	COG2965	DNA replication, synthesis of RNA primer
EZZ25_RS02585	COG0360	Binds together with S18 to 16S ribosomal RNA
EZZ25_RS02595	COG2906	2 iron, 2 sulfur cluster binding
EZZ25_RS02600	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EZZ25_RS02605	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EZZ25_RS02610	COG0049	tRNA binding
EZZ25_RS02625	COG2923	Belongs to the DsrF TusC family
EZZ25_RS02630	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
EZZ25_RS02635	COG2964	Protein conserved in bacteria
EZZ25_RS02640	COG0545	Peptidyl-prolyl cis-trans isomerase
EZZ25_RS02650	COG2900	Belongs to the SlyX family
EZZ25_RS02655	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
EZZ25_RS02660	COG0330	HflC and HflK could
EZZ25_RS02665	COG0330	HflC and HflK could
EZZ25_RS02670	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EZZ25_RS02675	COG1923	regulation of RNA biosynthetic process
EZZ25_RS02680	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EZZ25_RS02685	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EZZ25_RS02695	COG0802	atpase or kinase
EZZ25_RS02700	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EZZ25_RS02750	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
EZZ25_RS02755	COG1162	GTPase activity
EZZ25_RS02760	COG0688	phosphatidylethanolamine metabolic process
EZZ25_RS02765	COG0471	metal ion transport
EZZ25_RS02775	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
EZZ25_RS02780	COG4942	peptidase
EZZ25_RS02795	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EZZ25_RS02800	COG2816	NAD+ diphosphatase activity
EZZ25_RS02805	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
EZZ25_RS02810	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EZZ25_RS02815	COG0085	RNA polymerase activity
EZZ25_RS02820	COG0222	ribosome binding
EZZ25_RS02825	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EZZ25_RS02835	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EZZ25_RS02840	COG0250	Participates in transcription elongation, termination and antitermination
EZZ25_RS02845	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EZZ25_RS02850	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EZZ25_RS02875	COG1072	(Pantothenic acid kinase))
EZZ25_RS02885	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EZZ25_RS02895	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EZZ25_RS02940	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
EZZ25_RS02955	COG3118	belongs to the thioredoxin family
EZZ25_RS02960	COG0513	Belongs to the DEAD box helicase family
EZZ25_RS02965	COG0248	Ppx GppA phosphatase
EZZ25_RS02970	COG0784	Response regulator, receiver
EZZ25_RS02970	COG2205	protein histidine kinase activity
EZZ25_RS02975	COG2814	Major facilitator Superfamily
EZZ25_RS02995	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EZZ25_RS03000	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EZZ25_RS03005	COG0511	ligase activity, forming carbon-carbon bonds
EZZ25_RS03010	COG0439	Biotin carboxylase
EZZ25_RS03015	COG2264	protein methyltransferase activity
EZZ25_RS03020	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EZZ25_RS03025	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
EZZ25_RS03030	COG1609	Transcriptional regulator
EZZ25_RS03035	COG0129	dihydroxy-acid dehydratase activity
EZZ25_RS03040	COG3265	gluconokinase activity
EZZ25_RS03045	COG2610	gluconate transmembrane transporter activity
EZZ25_RS03050	COG0800	Aldolase
EZZ25_RS03070	COG0840	transmembrane signaling receptor activity
EZZ25_RS03075	COG1982	Orn Lys Arg decarboxylase major
EZZ25_RS03080	COG0531	amino acid
EZZ25_RS03085	COG3710	Transcriptional regulator
EZZ25_RS03090	COG0789	Transcriptional regulator
EZZ25_RS03105	COG0151	Belongs to the GarS family
EZZ25_RS03115	COG0776	regulation of translation
EZZ25_RS03120	COG1253	flavin adenine dinucleotide binding
EZZ25_RS03125	COG1940	carbohydrate kinase activity
EZZ25_RS03135	COG3068	Protein conserved in bacteria
EZZ25_RS03145	COG1573	uracil-dna glycosylase
EZZ25_RS03150	COG0668	transmembrane transport
EZZ25_RS03155	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
EZZ25_RS03210	COG1012	belongs to the aldehyde dehydrogenase family
EZZ25_RS03210	COG1454	alcohol dehydrogenase
EZZ25_RS03215	COG0318	PFAM AMP-dependent synthetase and ligase
EZZ25_RS03245	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
EZZ25_RS03250	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EZZ25_RS03255	COG0662	Cupin 2, conserved barrel domain protein
EZZ25_RS03255	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
EZZ25_RS03260	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EZZ25_RS03295	COG1519	Transferase
EZZ25_RS03325	COG3642	lipopolysaccharide core region biosynthetic process
EZZ25_RS03330	COG0859	PFAM glycosyl transferase family 9
EZZ25_RS03335	COG0463	Glycosyl transferase, family 2
EZZ25_RS03340	COG0859	PFAM glycosyl transferase family 9
EZZ25_RS03345	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EZZ25_RS03350	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EZZ25_RS03360	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EZZ25_RS03365	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EZZ25_RS03370	COG2003	Belongs to the UPF0758 family
EZZ25_RS03380	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EZZ25_RS03390	COG1309	transcriptional regulator
EZZ25_RS03395	COG1560	Kdo2-lipid A biosynthetic process
EZZ25_RS03400	COG1560	Kdo2-lipid A biosynthetic process
EZZ25_RS03405	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EZZ25_RS03410	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EZZ25_RS03415	COG1561	YicC-like family, N-terminal region
EZZ25_RS03420	COG2862	Uncharacterized protein family, UPF0114
EZZ25_RS03425	COG1263	PTS System
EZZ25_RS03425	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EZZ25_RS03430	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EZZ25_RS03455	COG1120	ATPase activity
EZZ25_RS03460	COG4774	siderophore transport
EZZ25_RS03465	COG1132	(ABC) transporter
EZZ25_RS03480	COG0514	ATP-dependent DNA helicase (RecQ)
EZZ25_RS03485	COG2962	Rard protein
EZZ25_RS03490	COG0405	Gamma-glutamyltransferase
EZZ25_RS03500	COG1280	lysine exporter protein (LysE YggA)
EZZ25_RS03515	COG0210	DNA helicase
EZZ25_RS03525	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
EZZ25_RS03530	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EZZ25_RS03570	COG3621	Patatin-like phospholipase
EZZ25_RS03595	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EZZ25_RS03600	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EZZ25_RS03615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EZZ25_RS03620	COG0601	transmembrane transport
EZZ25_RS03625	COG0747	negative chemotaxis
EZZ25_RS03685	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EZZ25_RS03690	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EZZ25_RS03695	COG2960	long-chain fatty acid transporting porin activity
EZZ25_RS03700	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EZZ25_RS03705	COG0583	DNA-binding transcription factor activity
EZZ25_RS03775	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
EZZ25_RS03780	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EZZ25_RS03785	COG1739	Uncharacterized protein family UPF0029
EZZ25_RS03790	COG1250	3-hydroxyacyl-CoA dehydrogenase
EZZ25_RS03790	COG1024	Enoyl-CoA hydratase
EZZ25_RS03795	COG0183	Belongs to the thiolase family
EZZ25_RS03800	COG0583	DNA-binding transcription factor activity
EZZ25_RS03805	COG2814	Major facilitator Superfamily
EZZ25_RS03815	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EZZ25_RS03820	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EZZ25_RS03825	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EZZ25_RS03830	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EZZ25_RS03835	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EZZ25_RS03840	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EZZ25_RS03850	COG0356	it plays a direct role in the translocation of protons across the membrane
EZZ25_RS03855	COG3312	ion transport
EZZ25_RS03860	COG1475	DNA binding
EZZ25_RS03865	COG1192	Involved in chromosome partitioning
EZZ25_RS03870	COG0357	Ribosomal RNA small subunit methyltransferase G
EZZ25_RS03875	COG0445	tRNA wobble uridine modification
EZZ25_RS03885	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EZZ25_RS03890	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EZZ25_RS03895	COG0706	membrane insertase activity
EZZ25_RS03905	COG0594	ribonuclease P activity
EZZ25_RS03910	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EZZ25_RS03915	COG1126	abc transporter atp-binding protein
EZZ25_RS03930	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EZZ25_RS03935	COG0592	DNA-directed DNA polymerase activity
EZZ25_RS03940	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EZZ25_RS03945	COG0187	DNA topoisomerase II activity
EZZ25_RS03960	COG0071	Belongs to the small heat shock protein (HSP20) family
EZZ25_RS03965	COG3977	Valine--pyruvate aminotransferase
EZZ25_RS03975	COG0751	glycine-tRNA ligase activity
EZZ25_RS03980	COG0752	glycyl-tRNA synthetase alpha subunit
EZZ25_RS03985	COG2119	membrane
EZZ25_RS04000	COG0425	Belongs to the sulfur carrier protein TusA family
EZZ25_RS04010	COG0604	alcohol dehydrogenase
EZZ25_RS04020	COG0129	dihydroxy-acid dehydratase activity
EZZ25_RS04025	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EZZ25_RS04040	COG0606	chelatase, subunit chli
EZZ25_RS04045	COG0204	Acyl-transferase
EZZ25_RS04050	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EZZ25_RS04055	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EZZ25_RS04065	COG3084	Protein conserved in bacteria
EZZ25_RS04075	COG4326	sporulation control protein
EZZ25_RS04080	COG1272	protein, Hemolysin III
EZZ25_RS04090	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EZZ25_RS04095	COG0569	domain protein
EZZ25_RS04100	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EZZ25_RS04100	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EZZ25_RS04105	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EZZ25_RS04110	COG0242	peptide deformylase activity
EZZ25_RS04115	COG1652	LysM domain
EZZ25_RS04120	COG0758	DNA mediated transformation
EZZ25_RS04125	COG2922	Belongs to the Smg family
EZZ25_RS04130	COG0551	DNA topoisomerase type I activity
EZZ25_RS04135	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EZZ25_RS04140	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EZZ25_RS04145	COG0009	L-threonylcarbamoyladenylate synthase
EZZ25_RS04150	COG0408	coproporphyrinogen oxidase activity
EZZ25_RS04155	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EZZ25_RS04165	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EZZ25_RS04205	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EZZ25_RS04210	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
EZZ25_RS04220	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EZZ25_RS04225	COG2104	thiamine diphosphate biosynthetic process
EZZ25_RS04230	COG2022	thiamine diphosphate biosynthetic process
EZZ25_RS04235	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EZZ25_RS04240	COG0006	proline dipeptidase activity
EZZ25_RS04240	COG0006	proline dipeptidase activity
EZZ25_RS04260	COG1522	sequence-specific DNA binding
EZZ25_RS04265	COG5002	protein histidine kinase activity
EZZ25_RS04265	COG5001	Diguanylate cyclase
EZZ25_RS04285	COG0589	response to stress
EZZ25_RS04295	COG1528	Iron-storage protein
EZZ25_RS04305	COG2081	HI0933 family
EZZ25_RS04315	COG1322	Protein conserved in bacteria
EZZ25_RS04320	COG2226	methyltransferase
EZZ25_RS04335	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EZZ25_RS04340	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EZZ25_RS04345	COG0805	protein transport
EZZ25_RS04350	COG1858	cytochrome C peroxidase
EZZ25_RS04355	COG0534	Mate efflux family protein
EZZ25_RS04365	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EZZ25_RS04375	COG2937	Belongs to the GPAT DAPAT family
EZZ25_RS04380	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EZZ25_RS04385	COG3161	chorismate lyase activity
EZZ25_RS04395	COG1580	Controls the rotational direction of flagella during chemotaxis
EZZ25_RS04400	COG0840	transmembrane signaling receptor activity
EZZ25_RS04410	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EZZ25_RS04420	COG0084	hydrolase, TatD family'
EZZ25_RS04435	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EZZ25_RS04435	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EZZ25_RS04455	COG3078	GTPase activator activity
EZZ25_RS04470	COG3071	HemY protein
EZZ25_RS04475	COG2959	enzyme of heme biosynthesis
EZZ25_RS04480	COG1587	Uroporphyrinogen-III synthase
EZZ25_RS04485	COG0181	hydroxymethylbilane synthase activity
EZZ25_RS04500	COG1965	Belongs to the frataxin family
EZZ25_RS04510	COG0019	diaminopimelate decarboxylase activity
EZZ25_RS04515	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EZZ25_RS04525	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
EZZ25_RS04530	COG1011	Hydrolase
EZZ25_RS04535	COG2200	EAL domain
EZZ25_RS04535	COG3287	FIST C domain
EZZ25_RS04535	COG2199	diguanylate cyclase activity
EZZ25_RS04555	COG0561	phosphatase activity
EZZ25_RS04560	COG2267	carboxylic ester hydrolase activity
EZZ25_RS04565	COG1280	lysine exporter protein (LysE YggA)
EZZ25_RS04570	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
EZZ25_RS04575	COG0783	Belongs to the Dps family
EZZ25_RS04615	COG0742	ribosomal rna small subunit methyltransferase
EZZ25_RS04620	COG0552	protein localization to endoplasmic reticulum
EZZ25_RS04625	COG2884	Cell division ATP-binding protein ftsE
EZZ25_RS04630	COG2177	Part of the ABC transporter FtsEX involved in
EZZ25_RS04635	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EZZ25_RS04640	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EZZ25_RS04655	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EZZ25_RS04660	COG4206	TonB-dependent receptor
EZZ25_RS04665	COG1404	Belongs to the peptidase S8 family
EZZ25_RS04670	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EZZ25_RS04740	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EZZ25_RS04745	COG3300	MHYT domain
EZZ25_RS04745	COG5001	Diguanylate cyclase
EZZ25_RS04755	COG3852	Histidine kinase
EZZ25_RS04765	COG0174	glutamine synthetase
EZZ25_RS04775	COG1217	gtp-binding protein TYPA
EZZ25_RS04780	COG1660	Displays ATPase and GTPase activities
EZZ25_RS04785	COG1295	ribonuclease BN
EZZ25_RS04790	COG1490	D-aminoacyl-tRNA deacylase activity
EZZ25_RS04795	COG0456	acetyltransferase
EZZ25_RS04805	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
EZZ25_RS04810	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EZZ25_RS04815	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EZZ25_RS04820	COG3031	protein transport across the cell outer membrane
EZZ25_RS04830	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EZZ25_RS04835	COG1459	type II secretion system
EZZ25_RS04840	COG2165	general secretion pathway protein
EZZ25_RS04845	COG2165	general secretion pathway protein
EZZ25_RS04850	COG2165	general secretion pathway protein
EZZ25_RS04855	COG4795	General secretion pathway protein
EZZ25_RS04860	COG3156	type II secretion system protein K
EZZ25_RS04865	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
EZZ25_RS04870	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
EZZ25_RS04880	COG1218	3'(2'),5'-bisphosphate nucleotidase
EZZ25_RS04885	COG0494	nUDIX hydrolase
EZZ25_RS04895	COG1040	competence protein
EZZ25_RS04900	COG0596	Alpha beta hydrolase
EZZ25_RS04910	COG2183	response to ionizing radiation
EZZ25_RS04915	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EZZ25_RS04920	COG2199	diguanylate cyclase activity
EZZ25_RS04935	COG2233	PERMEase
EZZ25_RS04940	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EZZ25_RS04945	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EZZ25_RS04950	COG1758	RNA polymerase activity
EZZ25_RS04955	COG0194	GDP metabolic process
EZZ25_RS04960	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
EZZ25_RS04965	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EZZ25_RS04985	COG4232	protein-disulfide reductase activity
EZZ25_RS04995	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EZZ25_RS05000	COG1027	Aspartate ammonia-lyase
EZZ25_RS05005	COG3706	GGDEF domain
EZZ25_RS05010	COG3030	protein affecting phage T7 exclusion by the F plasmid
EZZ25_RS05015	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EZZ25_RS05025	COG2205	protein histidine kinase activity
EZZ25_RS05030	COG0745	RESPONSE REGULATOR receiver
EZZ25_RS05040	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EZZ25_RS05045	COG0205	6-phosphofructokinase activity
EZZ25_RS05050	COG1494	fructose-1,6-bisphosphatase
EZZ25_RS05055	COG3074	FtsZ-dependent cytokinesis
EZZ25_RS05060	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EZZ25_RS05070	COG0527	aspartate kinase activity
EZZ25_RS05070	COG0460	homoserine dehydrogenase
EZZ25_RS05075	COG0626	cystathionine gamma-synthase activity
EZZ25_RS05080	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
EZZ25_RS05085	COG0281	malic enzyme
EZZ25_RS05090	COG0254	rRNA binding
EZZ25_RS05095	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EZZ25_RS05100	COG1609	Transcriptional regulator
EZZ25_RS05105	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EZZ25_RS05110	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EZZ25_RS05115	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
EZZ25_RS05120	COG1575	Belongs to the MenA family. Type 1 subfamily
EZZ25_RS05125	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EZZ25_RS05130	COG0534	Mate efflux family protein
EZZ25_RS05135	COG0149	triose-phosphate isomerase activity
EZZ25_RS05165	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EZZ25_RS05170	COG0459	protein refolding
EZZ25_RS05180	COG1509	lysine 2,3-aminomutase activity
EZZ25_RS05185	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EZZ25_RS05195	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
EZZ25_RS05200	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EZZ25_RS05205	COG1053	succinate dehydrogenase
EZZ25_RS05210	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
EZZ25_RS05215	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EZZ25_RS05220	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
EZZ25_RS05225	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EZZ25_RS05230	COG1045	serine acetyltransferase
EZZ25_RS05240	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
EZZ25_RS05245	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EZZ25_RS05250	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EZZ25_RS05255	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EZZ25_RS05260	COG0137	argininosuccinate synthase activity
EZZ25_RS05265	COG0165	Argininosuccinate lyase
EZZ25_RS05275	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EZZ25_RS05280	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EZZ25_RS05280	COG0678	peroxiredoxin activity
EZZ25_RS05290	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EZZ25_RS05320	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EZZ25_RS05325	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EZZ25_RS05335	COG0338	D12 class N6 adenine-specific DNA methyltransferase
EZZ25_RS05340	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EZZ25_RS05345	COG0546	phosphoglycolate phosphatase activity
EZZ25_RS05350	COG0180	Tryptophanyl-tRNA synthetase
EZZ25_RS05365	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EZZ25_RS05375	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EZZ25_RS05400	COG3954	Phosphoribulokinase
EZZ25_RS05410	COG0429	hydrolase of the alpha beta-hydrolase fold
EZZ25_RS05420	COG0488	(ABC) transporter
EZZ25_RS05425	COG2249	NAD(P)H dehydrogenase (quinone) activity
EZZ25_RS05440	COG1047	Peptidyl-prolyl cis-trans
EZZ25_RS05450	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EZZ25_RS05460	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
EZZ25_RS05465	COG3083	sulfuric ester hydrolase activity
EZZ25_RS05470	COG0557	exoribonuclease II activity
EZZ25_RS05475	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EZZ25_RS05480	COG0051	transcription antitermination factor activity, RNA binding
EZZ25_RS05485	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EZZ25_RS05490	COG0088	Forms part of the polypeptide exit tunnel
EZZ25_RS05495	COG0089	rRNA binding
EZZ25_RS05500	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EZZ25_RS05505	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EZZ25_RS05510	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EZZ25_RS05515	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EZZ25_RS05520	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EZZ25_RS05525	COG0255	Belongs to the universal ribosomal protein uL29 family
EZZ25_RS05530	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EZZ25_RS05535	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EZZ25_RS05540	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EZZ25_RS05545	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EZZ25_RS05550	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EZZ25_RS05555	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EZZ25_RS05565	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EZZ25_RS05570	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
EZZ25_RS05575	COG1841	ribosomal large subunit assembly
EZZ25_RS05580	COG0200	Binds to the 23S rRNA
EZZ25_RS05585	COG0201	protein transport
EZZ25_RS05590	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EZZ25_RS05595	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EZZ25_RS05600	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EZZ25_RS05605	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EZZ25_RS05610	COG0202	RNA polymerase activity
EZZ25_RS05615	COG0203	ribosomal protein L17
EZZ25_RS05625	COG0545	Peptidyl-prolyl cis-trans isomerase
EZZ25_RS05630	COG3266	domain, Protein
EZZ25_RS05630	COG3061	Opacity-associated protein A
EZZ25_RS05635	COG0697	spore germination
EZZ25_RS05640	COG2153	protein acetylation
EZZ25_RS05645	COG0513	Belongs to the DEAD box helicase family
EZZ25_RS05655	COG0737	Belongs to the 5'-nucleotidase family
EZZ25_RS05660	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EZZ25_RS05660	COG1648	precorrin-2 dehydrogenase activity
EZZ25_RS05665	COG0175	sulfate reduction
EZZ25_RS05670	COG2895	sulfate adenylyltransferase (ATP) activity
EZZ25_RS05675	COG0529	Catalyzes the synthesis of activated sulfate
EZZ25_RS05695	COG1136	(ABC) transporter
EZZ25_RS05710	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
EZZ25_RS05715	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EZZ25_RS05720	COG0729	surface antigen
EZZ25_RS05730	COG2105	PFAM AIG2 family protein
EZZ25_RS05735	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
EZZ25_RS05750	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EZZ25_RS05755	COG0163	prenyltransferase activity
EZZ25_RS05765	COG1178	ABC-type Fe3 transport system permease component
EZZ25_RS05770	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
EZZ25_RS05775	COG3028	Belongs to the UPF0307 family
EZZ25_RS05780	COG0312	modulator of DNA gyrase
EZZ25_RS05785	COG2239	Acts as a magnesium transporter
EZZ25_RS05790	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EZZ25_RS05795	COG1660	Displays ATPase and GTPase activities
EZZ25_RS05800	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EZZ25_RS05805	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EZZ25_RS05815	COG1137	ATPase activity
EZZ25_RS05820	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
EZZ25_RS05835	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
EZZ25_RS05835	COG0517	IMP dehydrogenase activity
EZZ25_RS05850	COG1127	ABC transporter
EZZ25_RS05855	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EZZ25_RS05860	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EZZ25_RS05865	COG2854	intermembrane phospholipid transfer
EZZ25_RS05875	COG5007	Belongs to the BolA IbaG family
EZZ25_RS05880	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EZZ25_RS05890	COG0251	oxidation-reduction process
EZZ25_RS05900	COG0540	Belongs to the ATCase OTCase family
EZZ25_RS05910	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
EZZ25_RS05925	COG0564	pseudouridine synthase activity
EZZ25_RS05930	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EZZ25_RS05935	COG0525	valine-tRNA ligase activity
EZZ25_RS05940	COG2927	DNA polymerase III (CHI subunit)
EZZ25_RS05945	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EZZ25_RS05950	COG0795	lipopolysaccharide-transporting ATPase activity
EZZ25_RS05955	COG0795	lipopolysaccharide-transporting ATPase activity
EZZ25_RS05970	COG3437	response regulator, receiver
EZZ25_RS06015	COG0066	3-isopropylmalate dehydratase activity
EZZ25_RS06020	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EZZ25_RS06025	COG0473	3-isopropylmalate dehydrogenase activity
EZZ25_RS06050	COG0583	DNA-binding transcription factor activity
EZZ25_RS06055	COG1022	Amp-dependent synthetase and ligase
EZZ25_RS06060	COG0028	Belongs to the TPP enzyme family
EZZ25_RS06065	COG0440	acetolactate synthase activity
EZZ25_RS06070	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EZZ25_RS06075	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EZZ25_RS06080	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EZZ25_RS06090	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
EZZ25_RS06095	COG3079	Belongs to the UPF0149 family
EZZ25_RS06100	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EZZ25_RS06105	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EZZ25_RS06120	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
EZZ25_RS06130	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EZZ25_RS06140	COG1595	DNA-templated transcription, initiation
EZZ25_RS06155	COG3086	response to oxidative stress
EZZ25_RS06160	COG0481	GTPase activity
EZZ25_RS06170	COG0571	ribonuclease III activity
EZZ25_RS06175	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EZZ25_RS06180	COG1381	Involved in DNA repair and RecF pathway recombination
EZZ25_RS06185	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
EZZ25_RS06205	COG5001	Diguanylate cyclase
EZZ25_RS06220	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EZZ25_RS06225	COG3956	TIGRFAM MazG family protein
EZZ25_RS06230	COG0504	CTP synthase activity
EZZ25_RS06235	COG0148	phosphopyruvate hydratase activity
EZZ25_RS06245	COG3267	Type II secretory pathway component ExeA
EZZ25_RS06245	COG3409	Peptidoglycan-binding domain 1 protein
EZZ25_RS06255	COG4991	sh3 domain protein
EZZ25_RS06260	COG0306	phosphate transporter
EZZ25_RS06265	COG1392	Phosphate transport regulator
EZZ25_RS06270	COG3025	triphosphatase activity
EZZ25_RS06275	COG0840	transmembrane signaling receptor activity
EZZ25_RS06280	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
EZZ25_RS06285	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EZZ25_RS06285	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
EZZ25_RS06290	COG1538	Outer membrane efflux protein
EZZ25_RS06295	COG0494	nUDIX hydrolase
EZZ25_RS06300	COG3151	Protein conserved in bacteria
EZZ25_RS06310	COG3150	esterase
EZZ25_RS06315	COG0187	DNA topoisomerase II activity
EZZ25_RS06320	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EZZ25_RS06335	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
EZZ25_RS06340	COG0237	dephospho-CoA kinase activity
EZZ25_RS06350	COG1459	type II secretion system
EZZ25_RS06355	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EZZ25_RS06360	COG4969	Belongs to the N-Me-Phe pilin family
EZZ25_RS06375	COG0716	FMN binding
EZZ25_RS06380	COG4974	Belongs to the 'phage' integrase family
EZZ25_RS06385	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EZZ25_RS06390	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EZZ25_RS06395	COG0737	Belongs to the 5'-nucleotidase family
EZZ25_RS06405	COG2186	Transcriptional regulator
EZZ25_RS06410	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
EZZ25_RS06415	COG0508	dehydrogenase complex catalyzes the overall conversion of
EZZ25_RS06420	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EZZ25_RS06435	COG3116	cell division
EZZ25_RS06440	COG0768	penicillin binding
EZZ25_RS06445	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EZZ25_RS06450	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EZZ25_RS06460	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EZZ25_RS06465	COG0772	Belongs to the SEDS family
EZZ25_RS06475	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EZZ25_RS06480	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EZZ25_RS06485	COG0849	cell division
EZZ25_RS06490	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EZZ25_RS06495	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
EZZ25_RS06505	COG0653	protein targeting
EZZ25_RS06510	COG0494	nUDIX hydrolase
EZZ25_RS06515	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EZZ25_RS06525	COG0505	Belongs to the CarA family
EZZ25_RS06530	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EZZ25_RS06545	COG0730	response to heat
EZZ25_RS06550	COG0583	DNA-binding transcription factor activity
EZZ25_RS06555	COG2860	membrane
EZZ25_RS06560	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EZZ25_RS06570	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EZZ25_RS06580	COG0493	'glutamate synthase
EZZ25_RS06585	COG0070	glutamate synthase
EZZ25_RS06585	COG0067	glutamate synthase
EZZ25_RS06585	COG0069	glutamate synthase activity
EZZ25_RS06595	COG0069	glutamate synthase activity
EZZ25_RS06595	COG0067	glutamate synthase
EZZ25_RS06595	COG0070	glutamate synthase
EZZ25_RS06600	COG1242	4 iron, 4 sulfur cluster binding
EZZ25_RS06605	COG5001	Diguanylate cyclase
EZZ25_RS06605	COG4251	negative regulation of phosphorylation
EZZ25_RS06605	COG3706	GGDEF domain
EZZ25_RS06605	COG2203	Gaf domain
EZZ25_RS06610	COG0784	Response regulator, receiver
EZZ25_RS06610	COG2198	Histidine kinase
EZZ25_RS06610	COG5002	protein histidine kinase activity
EZZ25_RS06615	COG0745	RESPONSE REGULATOR receiver
EZZ25_RS06625	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EZZ25_RS06645	COG0083	homoserine kinase activity
EZZ25_RS06650	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
EZZ25_RS06655	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
EZZ25_RS06660	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
EZZ25_RS06665	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EZZ25_RS06680	COG1115	amino acid carrier protein
EZZ25_RS06685	COG3022	response to hydroperoxide
EZZ25_RS06690	COG0084	hydrolase, TatD family'
EZZ25_RS06695	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EZZ25_RS06705	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EZZ25_RS06710	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
EZZ25_RS06715	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
EZZ25_RS06720	COG0813	purine-nucleoside phosphorylase activity
EZZ25_RS06730	COG0560	Phosphoserine phosphatase
EZZ25_RS06740	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EZZ25_RS06745	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EZZ25_RS06750	COG1022	Amp-dependent synthetase and ligase
EZZ25_RS06765	COG3250	beta-galactosidase activity
EZZ25_RS06770	COG1609	Transcriptional regulator
EZZ25_RS06775	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EZZ25_RS06790	COG0189	ligase activity
EZZ25_RS06790	COG0569	domain protein
EZZ25_RS06795	COG0456	acetyltransferase
EZZ25_RS06805	COG2171	N-acyltransferase activity
EZZ25_RS06810	COG3141	response to X-ray
EZZ25_RS06825	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
EZZ25_RS06830	COG1074	ATP-dependent DNA helicase activity
EZZ25_RS06835	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EZZ25_RS06845	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EZZ25_RS06845	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
EZZ25_RS06855	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
EZZ25_RS06860	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EZZ25_RS06865	COG2166	iron-sulfur cluster assembly
EZZ25_RS06870	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EZZ25_RS06875	COG0693	protein deglycase activity
EZZ25_RS06880	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EZZ25_RS06885	COG3248	Nucleoside-binding outer membrane protein
EZZ25_RS06895	COG1595	DNA-templated transcription, initiation
EZZ25_RS06905	COG2211	Major facilitator Superfamily
EZZ25_RS06910	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EZZ25_RS06920	COG2813	Specifically methylates the guanine in position
EZZ25_RS06925	COG0271	Belongs to the BolA IbaG family
EZZ25_RS06930	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EZZ25_RS06935	COG1805	sodium ion transport
EZZ25_RS06940	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EZZ25_RS06945	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EZZ25_RS06950	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EZZ25_RS06955	COG2871	sodium ion transport
EZZ25_RS06960	COG1477	protein flavinylation
EZZ25_RS06980	COG3706	GGDEF domain
EZZ25_RS06985	COG0733	neurotransmitter:sodium symporter activity
EZZ25_RS06995	COG0189	ligase activity
EZZ25_RS07000	COG4067	protein conserved in archaea
EZZ25_RS07000	COG0189	ligase activity
EZZ25_RS07005	COG2195	Cleaves the N-terminal amino acid of tripeptides
EZZ25_RS07010	COG2252	PERMEase
EZZ25_RS07015	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
EZZ25_RS07020	COG1073	alpha beta
EZZ25_RS07030	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EZZ25_RS07035	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EZZ25_RS07040	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EZZ25_RS07045	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EZZ25_RS07045	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EZZ25_RS07060	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EZZ25_RS07065	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EZZ25_RS07070	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
EZZ25_RS07075	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EZZ25_RS07085	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
EZZ25_RS07090	COG0024	Methionine aminopeptidase
EZZ25_RS07095	COG0052	Belongs to the universal ribosomal protein uS2 family
EZZ25_RS07100	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EZZ25_RS07105	COG0528	UMP kinase activity
EZZ25_RS07110	COG0233	cytoplasmic translational termination
EZZ25_RS07115	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EZZ25_RS07120	COG0575	Belongs to the CDS family
EZZ25_RS07125	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
EZZ25_RS07130	COG0750	zinc metalloprotease
EZZ25_RS07140	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
EZZ25_RS07145	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EZZ25_RS07150	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EZZ25_RS07155	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EZZ25_RS07160	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EZZ25_RS07165	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EZZ25_RS07170	COG0587	DNA-directed DNA polymerase activity
EZZ25_RS07175	COG0825	malonyl-CoA metabolic process
EZZ25_RS07180	COG0037	tRNA processing
EZZ25_RS07190	COG3479	Phenolic acid decarboxylase
EZZ25_RS07195	COG0347	Belongs to the P(II) protein family
EZZ25_RS07200	COG3021	interspecies interaction between organisms
EZZ25_RS07205	COG0741	lytic transglycosylase activity
EZZ25_RS07205	COG1388	LysM domain
EZZ25_RS07210	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EZZ25_RS07215	COG2226	methyltransferase
EZZ25_RS07220	COG0328	RNA-DNA hybrid ribonuclease activity
EZZ25_RS07235	COG1960	acyl-CoA dehydrogenase activity
EZZ25_RS07240	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EZZ25_RS07245	COG0121	glutamine amidotransferase
EZZ25_RS07250	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EZZ25_RS07255	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EZZ25_RS07260	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
EZZ25_RS07270	COG1187	pseudouridine synthase activity
EZZ25_RS07275	COG2840	Smr protein MutS2
EZZ25_RS07290	COG3735	TraB family
EZZ25_RS07305	COG2217	Heavy metal translocating P-type atpase
EZZ25_RS07305	COG2608	mercury ion transmembrane transporter activity
EZZ25_RS07310	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EZZ25_RS07325	COG1629	transport
EZZ25_RS07325	COG4774	siderophore transport
EZZ25_RS07330	COG2375	cellular response to nickel ion
EZZ25_RS07335	COG3433	isochorismatase activity
EZZ25_RS07335	COG2226	methyltransferase
EZZ25_RS07335	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EZZ25_RS07370	COG0784	Response regulator, receiver
EZZ25_RS07370	COG0835	chemotaxis
EZZ25_RS07375	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EZZ25_RS07380	COG1815	bacterial-type flagellum-dependent cell motility
EZZ25_RS07395	COG1749	Flagellar hook protein flgE
EZZ25_RS07400	COG4787	bacterial-type flagellum-dependent cell motility
EZZ25_RS07410	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
EZZ25_RS07415	COG1706	bacterial-type flagellum-dependent cell motility
EZZ25_RS07420	COG3951	Flagellar rod assembly protein muramidase FlgJ
EZZ25_RS07420	COG1705	Flagellar rod assembly protein muramidase FlgJ
EZZ25_RS07435	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EZZ25_RS07440	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EZZ25_RS07535	COG0012	GTP binding
EZZ25_RS07540	COG0193	aminoacyl-tRNA hydrolase activity
EZZ25_RS07545	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EZZ25_RS07555	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
EZZ25_RS07560	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EZZ25_RS07565	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EZZ25_RS07570	COG2890	protein-(glutamine-N5) methyltransferase activity
EZZ25_RS07580	COG2912	Transglutaminase-like superfamily
EZZ25_RS07585	COG2877	3-deoxy-8-phosphooctulonate synthase activity
EZZ25_RS07590	COG0737	Belongs to the 5'-nucleotidase family
EZZ25_RS07595	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EZZ25_RS07600	COG2233	PERMEase
EZZ25_RS07620	COG1393	Belongs to the ArsC family
EZZ25_RS07625	COG4783	chaperone-mediated protein folding
EZZ25_RS07645	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EZZ25_RS07660	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
EZZ25_RS07670	COG1876	peptidase activity
EZZ25_RS07680	COG1393	Belongs to the ArsC family
EZZ25_RS07700	COG2837	iron assimilation
EZZ25_RS07705	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EZZ25_RS07710	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EZZ25_RS07715	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EZZ25_RS07720	COG1334	flagellar protein FlaG
EZZ25_RS07725	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
EZZ25_RS07735	COG1516	flagellar protein fliS
EZZ25_RS07755	COG1677	Flagellar hook-basal body complex protein FliE
EZZ25_RS07765	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EZZ25_RS07770	COG1317	bacterial-type flagellum organization
EZZ25_RS07795	COG1580	Controls the rotational direction of flagella during chemotaxis
EZZ25_RS07820	COG1987	bacterial-type flagellum assembly
EZZ25_RS07825	COG1684	flagellar biosynthetic protein fliR
EZZ25_RS07835	COG2840	Smr protein MutS2
EZZ25_RS07840	COG2890	protein-(glutamine-N5) methyltransferase activity
EZZ25_RS07850	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EZZ25_RS07855	COG2860	membrane
EZZ25_RS07860	COG3101	peptidyl-lysine hydroxylation
EZZ25_RS07870	COG0431	NADPH-dependent FMN reductase
EZZ25_RS07875	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
EZZ25_RS07875	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EZZ25_RS07880	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EZZ25_RS07885	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EZZ25_RS07890	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EZZ25_RS07895	COG0735	belongs to the Fur family
EZZ25_RS07905	COG0583	DNA-binding transcription factor activity
EZZ25_RS07915	COG1346	cytolysis
EZZ25_RS07930	COG0596	Alpha beta hydrolase
EZZ25_RS07935	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
EZZ25_RS07940	COG0033	Phosphoglucomutase
EZZ25_RS07950	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EZZ25_RS07955	COG0372	Belongs to the citrate synthase family
EZZ25_RS07960	COG2009	succinate dehydrogenase
EZZ25_RS07965	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
EZZ25_RS07970	COG1053	succinate dehydrogenase
EZZ25_RS07980	COG0567	Dehydrogenase, E1 component
EZZ25_RS07985	COG0508	dehydrogenase complex catalyzes the overall conversion of
EZZ25_RS07990	COG0045	succinate-CoA ligase (ADP-forming) activity
EZZ25_RS08000	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EZZ25_RS08005	COG1121	(ABC) transporter
EZZ25_RS08010	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
EZZ25_RS08015	COG4977	sequence-specific DNA binding
EZZ25_RS08020	COG1918	ferrous iron import across plasma membrane
EZZ25_RS08040	COG0018	arginyl-trna synthetase
EZZ25_RS08050	COG1025	Belongs to the peptidase M16 family
EZZ25_RS08055	COG2062	phosphohistidine phosphatase, SixA
EZZ25_RS08085	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
EZZ25_RS08090	COG0784	Response regulator, receiver
EZZ25_RS08090	COG0643	Histidine kinase
EZZ25_RS08090	COG2198	Histidine kinase
EZZ25_RS08095	COG2201	protein-glutamate methylesterase activity
EZZ25_RS08100	COG1192	Involved in chromosome partitioning
EZZ25_RS08110	COG0835	chemotaxis
EZZ25_RS08120	COG4133	protoheme IX ABC transporter activity
EZZ25_RS08125	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EZZ25_RS08130	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EZZ25_RS08140	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
EZZ25_RS08145	COG1138	Cytochrome C-type biogenesis protein
EZZ25_RS08150	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EZZ25_RS08155	COG3088	subunit of a heme lyase
EZZ25_RS08155	COG4235	cytochrome complex assembly
EZZ25_RS08165	COG2853	Lipoprotein
EZZ25_RS08185	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EZZ25_RS08190	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EZZ25_RS08195	COG0123	including yeast histone deacetylase and acetoin utilization protein
EZZ25_RS08210	COG3083	sulfuric ester hydrolase activity
EZZ25_RS08215	COG3082	Protein of unknown function (DUF1414)
EZZ25_RS08220	COG3081	Nucleoid-associated protein
EZZ25_RS08230	COG1757	Na H antiporter
EZZ25_RS08235	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EZZ25_RS08240	COG2095	MarC family integral membrane protein
EZZ25_RS08245	COG1454	alcohol dehydrogenase
EZZ25_RS08245	COG1012	belongs to the aldehyde dehydrogenase family
EZZ25_RS08260	COG0659	secondary active sulfate transmembrane transporter activity
EZZ25_RS08265	COG1530	ribonuclease E activity
EZZ25_RS08280	COG0564	pseudouridine synthase activity
EZZ25_RS08285	COG0424	maF-like protein
EZZ25_RS08290	COG1399	metal-binding, possibly nucleic acid-binding protein
EZZ25_RS08295	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EZZ25_RS08300	COG0416	fatty acid biosynthetic process
EZZ25_RS08305	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EZZ25_RS08315	COG1028	Short-chain dehydrogenase reductase Sdr
EZZ25_RS08320	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EZZ25_RS08325	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EZZ25_RS08330	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EZZ25_RS08335	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EZZ25_RS08340	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EZZ25_RS08350	COG0084	hydrolase, TatD family'
EZZ25_RS08355	COG1263	PTS System
EZZ25_RS08355	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EZZ25_RS08365	COG0733	neurotransmitter:sodium symporter activity
EZZ25_RS08380	COG4667	esterase of the alpha-beta hydrolase superfamily
EZZ25_RS08390	COG1940	carbohydrate kinase activity
EZZ25_RS08395	COG0835	chemotaxis
EZZ25_RS08395	COG0784	Response regulator, receiver
EZZ25_RS08410	COG2226	methyltransferase
EZZ25_RS08420	COG0676	glucose-6-phosphate 1-epimerase activity
EZZ25_RS08425	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EZZ25_RS08430	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EZZ25_RS08445	COG3139	Protein of unknown function (DUF1315)
EZZ25_RS08450	COG0252	asparaginase activity
EZZ25_RS08455	COG0616	signal peptide processing
EZZ25_RS08460	COG0446	pyridine nucleotide-disulphide oxidoreductase
EZZ25_RS08460	COG1902	pentaerythritol trinitrate reductase activity
EZZ25_RS08465	COG0788	formyltetrahydrofolate deformylase activity
EZZ25_RS08480	COG1199	ATP-dependent helicase activity
EZZ25_RS08485	COG1214	PFAM Peptidase M22, glycoprotease
EZZ25_RS08500	COG0596	Alpha beta hydrolase
EZZ25_RS08505	COG0318	PFAM AMP-dependent synthetase and ligase
EZZ25_RS08510	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
EZZ25_RS08525	COG0232	Belongs to the dGTPase family. Type 2 subfamily
EZZ25_RS08530	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
EZZ25_RS08535	COG0436	Aminotransferase
EZZ25_RS08540	COG1169	isochorismate synthase
EZZ25_RS08545	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
EZZ25_RS08550	COG0596	Alpha beta hydrolase
EZZ25_RS08570	COG3135	benzoate transporter
EZZ25_RS08575	COG1396	sequence-specific DNA binding
EZZ25_RS08580	COG0840	transmembrane signaling receptor activity
EZZ25_RS08605	COG3015	lipoprotein NlpE involved in copper resistance
EZZ25_RS08610	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
EZZ25_RS08615	COG2894	cell division
EZZ25_RS08620	COG0850	regulation of cytokinetic process
EZZ25_RS08625	COG3100	YcgL domain-containing protein
EZZ25_RS08630	COG2951	lytic endotransglycosylase activity
EZZ25_RS08640	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EZZ25_RS08645	COG3469	chitinase activity
EZZ25_RS08645	COG3325	Belongs to the glycosyl hydrolase 18 family
EZZ25_RS08650	COG3005	denitrification pathway
EZZ25_RS08655	COG0243	molybdopterin cofactor binding
EZZ25_RS08675	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EZZ25_RS08685	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EZZ25_RS08725	COG4589	Belongs to the CDS family
EZZ25_RS08735	COG3300	MHYT domain
EZZ25_RS08735	COG5001	Diguanylate cyclase
EZZ25_RS08750	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EZZ25_RS08755	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EZZ25_RS08760	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
EZZ25_RS08765	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EZZ25_RS08775	COG4191	Histidine kinase
EZZ25_RS08785	COG0544	peptidyl-prolyl cis-trans isomerase activity
EZZ25_RS08795	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EZZ25_RS08800	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EZZ25_RS08805	COG0776	regulation of translation
EZZ25_RS08810	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EZZ25_RS08815	COG1555	photosystem II stabilization
EZZ25_RS08820	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EZZ25_RS08825	COG0539	negative regulation of cytoplasmic translation
EZZ25_RS08830	COG0776	regulation of translation
EZZ25_RS08835	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
EZZ25_RS08840	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
EZZ25_RS08880	COG0583	DNA-binding transcription factor activity
EZZ25_RS08890	COG0686	Belongs to the AlaDH PNT family
EZZ25_RS08900	COG1674	ftsk spoiiie
EZZ25_RS08905	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
EZZ25_RS08910	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EZZ25_RS08915	COG2186	Transcriptional regulator
EZZ25_RS08930	COG0537	adenosine 5'-monophosphoramidase activity
EZZ25_RS08955	COG3150	esterase
EZZ25_RS08960	COG1252	NADH dehydrogenase
EZZ25_RS08980	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EZZ25_RS08990	COG4591	ABC-type transport system involved in lipoprotein release permease component
EZZ25_RS08995	COG1136	(ABC) transporter
EZZ25_RS09000	COG4591	ABC-type transport system involved in lipoprotein release permease component
EZZ25_RS09010	COG2333	competence protein COMEC
EZZ25_RS09010	COG0658	competence protein
EZZ25_RS09015	COG1132	(ABC) transporter
EZZ25_RS09020	COG1663	tetraacyldisaccharide 4'-kinase activity
EZZ25_RS09025	COG2835	tetraacyldisaccharide 4'-kinase activity
EZZ25_RS09030	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
EZZ25_RS09035	COG2719	SpoVR family
EZZ25_RS09040	COG2718	Belongs to the UPF0229 family
EZZ25_RS09045	COG2766	serine protein kinase
EZZ25_RS09050	COG3013	Belongs to the UPF0304 family
EZZ25_RS09060	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EZZ25_RS09070	COG0840	transmembrane signaling receptor activity
EZZ25_RS09080	COG1882	Formate acetyltransferase
EZZ25_RS09110	COG4160	amino acid transport
EZZ25_RS09115	COG0708	Exodeoxyribonuclease III
EZZ25_RS09120	COG0840	transmembrane signaling receptor activity
EZZ25_RS09130	COG3923	Primosomal replication protein n
EZZ25_RS09135	COG0730	response to heat
EZZ25_RS09140	COG1199	ATP-dependent helicase activity
EZZ25_RS09155	COG3012	SEC-C Motif Domain Protein
EZZ25_RS09160	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
EZZ25_RS09165	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EZZ25_RS09170	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EZZ25_RS09175	COG0215	cysteine-tRNA ligase activity
EZZ25_RS09180	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
EZZ25_RS09185	COG0632	four-way junction helicase activity
EZZ25_RS09195	COG1271	oxidase subunit
EZZ25_RS09200	COG1294	oxidase, subunit
EZZ25_RS09205	COG4890	Cyd operon protein YbgT
EZZ25_RS09210	COG3790	cyd operon protein YbgE
EZZ25_RS09215	COG0824	Thioesterase
EZZ25_RS09220	COG0811	peptide transport
EZZ25_RS09235	COG0823	Involved in the tonB-independent uptake of proteins
EZZ25_RS09240	COG2885	chlorophyll binding
EZZ25_RS09250	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EZZ25_RS09260	COG0784	Response regulator, receiver
EZZ25_RS09260	COG5002	protein histidine kinase activity
EZZ25_RS09270	COG1482	cell wall glycoprotein biosynthetic process
EZZ25_RS09275	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EZZ25_RS09275	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EZZ25_RS09275	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EZZ25_RS09280	COG2207	Transcriptional regulator
EZZ25_RS09290	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EZZ25_RS09295	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EZZ25_RS09300	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EZZ25_RS09310	COG1012	belongs to the aldehyde dehydrogenase family
EZZ25_RS09315	COG3284	Transcriptional regulator
EZZ25_RS09320	COG4628	conserved protein (DUF2132)
EZZ25_RS09330	COG0415	Belongs to the DNA photolyase family
EZZ25_RS09380	COG2003	Belongs to the UPF0758 family
EZZ25_RS09390	COG4409	exo-alpha-(2->6)-sialidase activity
EZZ25_RS09395	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EZZ25_RS09400	COG1940	carbohydrate kinase activity
EZZ25_RS09415	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EZZ25_RS09420	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
EZZ25_RS09425	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EZZ25_RS09430	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EZZ25_RS09435	COG1737	Transcriptional regulator
EZZ25_RS09440	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
EZZ25_RS09445	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
EZZ25_RS09455	COG4932	domain protein
EZZ25_RS09455	COG5492	domain, Protein
EZZ25_RS09480	COG2267	carboxylic ester hydrolase activity
EZZ25_RS09490	COG3064	Membrane
EZZ25_RS09610	COG4789	Type iii secretion
EZZ25_RS09615	COG4792	protein secretion
EZZ25_RS09645	COG3710	Transcriptional regulator
EZZ25_RS09655	COG4790	Type iii secretion
EZZ25_RS09735	COG0582	viral genome integration into host DNA
EZZ25_RS09750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EZZ25_RS09760	COG3008	intermembrane lipid transfer
EZZ25_RS09760	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EZZ25_RS09765	COG2995	paraquat-inducible protein a
EZZ25_RS09775	COG1309	transcriptional regulator
EZZ25_RS09780	COG1012	belongs to the aldehyde dehydrogenase family
EZZ25_RS09800	COG1960	acyl-CoA dehydrogenase activity
EZZ25_RS09805	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EZZ25_RS09810	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EZZ25_RS09815	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
EZZ25_RS09820	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
EZZ25_RS09840	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EZZ25_RS09845	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EZZ25_RS09850	COG0297	glycogen (starch) synthase activity
EZZ25_RS09870	COG3070	regulator of competence-specific genes
EZZ25_RS09875	COG1609	Transcriptional regulator
EZZ25_RS09890	COG0745	RESPONSE REGULATOR receiver
EZZ25_RS09895	COG1434	Gram-negative-bacterium-type cell wall biogenesis
EZZ25_RS09900	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EZZ25_RS09905	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
EZZ25_RS09910	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
EZZ25_RS09930	COG1032	radical SAM domain protein
EZZ25_RS09935	COG5001	Diguanylate cyclase
EZZ25_RS09940	COG0612	Peptidase, M16
EZZ25_RS09955	COG0583	DNA-binding transcription factor activity
EZZ25_RS09960	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EZZ25_RS09970	COG2350	Protein conserved in bacteria
EZZ25_RS09975	COG1607	acyl-coa hydrolase
EZZ25_RS09990	COG1434	Gram-negative-bacterium-type cell wall biogenesis
EZZ25_RS09995	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EZZ25_RS10010	COG2116	formate transmembrane transporter activity
EZZ25_RS10020	COG4459	periplasmic nitrate reductase
EZZ25_RS10025	COG3005	denitrification pathway
EZZ25_RS10030	COG0243	molybdopterin cofactor binding
EZZ25_RS10055	COG1227	inorganic diphosphatase activity
EZZ25_RS10070	COG4172	Belongs to the ABC transporter superfamily
EZZ25_RS10085	COG4168	peptide transport system, permease
EZZ25_RS10095	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
EZZ25_RS10100	COG1842	Phage shock protein A
EZZ25_RS10115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EZZ25_RS10130	COG2818	Glycosylase
EZZ25_RS10135	COG0626	cystathionine gamma-synthase activity
EZZ25_RS10145	COG0733	neurotransmitter:sodium symporter activity
EZZ25_RS10150	COG0564	pseudouridine synthase activity
EZZ25_RS10155	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EZZ25_RS10160	COG4136	ATPase activity
EZZ25_RS10165	COG4135	transport system, permease component
EZZ25_RS10170	COG4134	Bacterial extracellular solute-binding protein
EZZ25_RS10180	COG3313	Fe-S protein
EZZ25_RS10190	COG0842	Transport permease protein
EZZ25_RS10195	COG1131	(ABC) transporter
EZZ25_RS10200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EZZ25_RS10205	COG0814	amino acid
EZZ25_RS10215	COG2239	Acts as a magnesium transporter
EZZ25_RS10220	COG2205	protein histidine kinase activity
EZZ25_RS10220	COG0784	Response regulator, receiver
EZZ25_RS10235	COG4934	collagen metabolic process
EZZ25_RS10280	COG5001	Diguanylate cyclase
EZZ25_RS10280	COG2203	Gaf domain
EZZ25_RS10280	COG4251	negative regulation of phosphorylation
EZZ25_RS10280	COG3706	GGDEF domain
EZZ25_RS10285	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
EZZ25_RS10305	COG1061	Type III restriction enzyme res subunit
EZZ25_RS10310	COG1187	pseudouridine synthase activity
EZZ25_RS10315	COG2814	Major facilitator Superfamily
EZZ25_RS10325	COG0702	epimerase
EZZ25_RS10330	COG0534	Mate efflux family protein
EZZ25_RS10335	COG4181	ATPase activity
EZZ25_RS10340	COG0577	efflux transmembrane transporter activity
EZZ25_RS10350	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EZZ25_RS10365	COG1748	Saccharopine dehydrogenase
EZZ25_RS10380	COG1538	Outer membrane efflux protein
EZZ25_RS10420	COG0583	DNA-binding transcription factor activity
EZZ25_RS10430	COG1451	nucleotide metabolic process
EZZ25_RS10445	COG3063	Type IV pilus biogenesis stability protein PilW
EZZ25_RS10450	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
EZZ25_RS10470	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EZZ25_RS10485	COG3290	protein histidine kinase activity
EZZ25_RS10490	COG4565	transcriptional regulatory protein
EZZ25_RS10500	COG0784	Response regulator, receiver
EZZ25_RS10500	COG0835	chemotaxis
EZZ25_RS10545	COG1085	galactose-1-phosphate uridylyltransferase
EZZ25_RS10550	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
EZZ25_RS10555	COG2017	converts alpha-aldose to the beta-anomer
EZZ25_RS10565	COG2199	diguanylate cyclase activity
EZZ25_RS10565	COG2200	EAL domain
EZZ25_RS10580	COG3527	Alpha-acetolactate decarboxylase
EZZ25_RS10600	COG0753	catalase activity
EZZ25_RS10620	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EZZ25_RS10630	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EZZ25_RS10645	COG3097	Belongs to the UPF0267 family
EZZ25_RS10670	COG1271	oxidase subunit
EZZ25_RS10675	COG1294	oxidase, subunit
EZZ25_RS10680	COG1136	(ABC) transporter
EZZ25_RS10680	COG4591	ABC-type transport system involved in lipoprotein release permease component
EZZ25_RS10685	COG1136	(ABC) transporter
EZZ25_RS10685	COG0577	efflux transmembrane transporter activity
EZZ25_RS10690	COG1136	(ABC) transporter
EZZ25_RS10690	COG0577	efflux transmembrane transporter activity
EZZ25_RS10720	COG2723	6-phospho-beta-galactosidase activity
EZZ25_RS10725	COG1609	Transcriptional regulator
EZZ25_RS10730	COG0251	oxidation-reduction process
EZZ25_RS10735	COG2731	YhcH YjgK YiaL family protein
EZZ25_RS10740	COG0584	glycerophosphoryl diester phosphodiesterase
EZZ25_RS10745	COG1349	DNA-binding transcription factor activity
EZZ25_RS10750	COG3842	ATPase activity
EZZ25_RS10755	COG0395	ABC-type sugar transport system, permease component
EZZ25_RS10760	COG1175	transmembrane transport
EZZ25_RS10775	COG0811	peptide transport
EZZ25_RS10780	COG0811	peptide transport
EZZ25_RS10785	COG0848	biopolymer transport protein
EZZ25_RS10790	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
EZZ25_RS10800	COG1793	dna ligase
EZZ25_RS10810	COG0534	Mate efflux family protein
EZZ25_RS10820	COG3001	Fructosamine kinase
EZZ25_RS10830	COG0791	NLP P60 protein
EZZ25_RS10835	COG0840	transmembrane signaling receptor activity
EZZ25_RS10835	COG3290	protein histidine kinase activity
EZZ25_RS10845	COG3148	PFAM DTW domain containing protein
EZZ25_RS10850	COG1940	carbohydrate kinase activity
EZZ25_RS10860	COG0303	'Molybdopterin
EZZ25_RS10865	COG0746	molybdenum cofactor guanylyltransferase activity
EZZ25_RS10870	COG3842	ATPase activity
EZZ25_RS10875	COG4662	Binding-protein-dependent transport system inner membrane component
EZZ25_RS10885	COG2204	response regulator
EZZ25_RS10890	COG3852	Histidine kinase
EZZ25_RS10895	COG0488	(ABC) transporter
EZZ25_RS10900	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EZZ25_RS10930	COG3383	formate dehydrogenase (NAD+) activity
EZZ25_RS10930	COG0243	molybdopterin cofactor binding
EZZ25_RS10935	COG0437	4 iron, 4 sulfur cluster binding
EZZ25_RS10950	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EZZ25_RS10955	COG1666	GTP binding
EZZ25_RS10960	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EZZ25_RS10975	COG2996	Protein conserved in bacteria
EZZ25_RS10985	COG3008	intermembrane lipid transfer
EZZ25_RS10990	COG2995	paraquat-inducible protein a
EZZ25_RS10995	COG1132	(ABC) transporter
EZZ25_RS11000	COG1956	GAF domain-containing protein
EZZ25_RS11005	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
EZZ25_RS11020	COG0308	aminopeptidase N
EZZ25_RS11035	COG0167	dihydroorotate dehydrogenase activity
EZZ25_RS11045	COG0116	Belongs to the methyltransferase superfamily
EZZ25_RS11045	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EZZ25_RS11055	COG0488	(ABC) transporter
EZZ25_RS11070	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EZZ25_RS11075	COG1067	ATP-dependent peptidase activity
EZZ25_RS11080	COG3120	sequence-specific DNA binding
EZZ25_RS11095	COG3064	Membrane
EZZ25_RS11095	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
EZZ25_RS11095	COG1073	alpha beta
EZZ25_RS11100	COG2994	toxin metabolic process
EZZ25_RS11125	COG0784	Response regulator, receiver
EZZ25_RS11125	COG2205	protein histidine kinase activity
EZZ25_RS11140	COG3278	Belongs to the heme-copper respiratory oxidase family
EZZ25_RS11155	COG2010	Cytochrome c
EZZ25_RS11165	COG2217	Heavy metal translocating P-type atpase
EZZ25_RS11180	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EZZ25_RS11185	COG0589	response to stress
EZZ25_RS11190	COG0037	tRNA processing
EZZ25_RS11210	COG3842	ATPase activity
EZZ25_RS11220	COG1177	transmembrane transport
EZZ25_RS11230	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EZZ25_RS11245	COG1115	amino acid carrier protein
EZZ25_RS11250	COG1280	lysine exporter protein (LysE YggA)
EZZ25_RS11270	COG3501	Rhs element vgr protein
EZZ25_RS11280	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
EZZ25_RS11290	COG2814	Major facilitator Superfamily
EZZ25_RS11295	COG1566	PFAM secretion protein HlyD family protein
EZZ25_RS11300	COG1538	Outer membrane efflux protein
EZZ25_RS11310	COG0513	Belongs to the DEAD box helicase family
EZZ25_RS11320	COG0840	transmembrane signaling receptor activity
EZZ25_RS11325	COG0840	transmembrane signaling receptor activity
EZZ25_RS11325	COG3290	protein histidine kinase activity
EZZ25_RS11330	COG0835	chemotaxis
EZZ25_RS11335	COG2201	protein-glutamate methylesterase activity
EZZ25_RS11345	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EZZ25_RS11350	COG0643	Histidine kinase
EZZ25_RS11350	COG0784	Response regulator, receiver
EZZ25_RS11350	COG2198	Histidine kinase
EZZ25_RS11355	COG0643	Histidine kinase
EZZ25_RS11355	COG2198	Histidine kinase
EZZ25_RS11365	COG0745	RESPONSE REGULATOR receiver
EZZ25_RS11380	COG0415	Belongs to the DNA photolyase family
EZZ25_RS11385	COG0477	Major facilitator Superfamily
EZZ25_RS11390	COG0583	DNA-binding transcription factor activity
EZZ25_RS11400	COG0095	Lipoate-protein ligase
EZZ25_RS11405	COG0443	Heat shock 70 kDa protein
EZZ25_RS11415	COG1643	Atp-dependent helicase
EZZ25_RS11455	COG0443	Heat shock 70 kDa protein
EZZ25_RS11460	COG0443	Heat shock 70 kDa protein
EZZ25_RS11465	COG3706	GGDEF domain
EZZ25_RS11495	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EZZ25_RS11500	COG0602	queuosine metabolic process
EZZ25_RS11505	COG0561	phosphatase activity
EZZ25_RS11515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EZZ25_RS11520	COG4597	amino acid ABC transporter
EZZ25_RS11525	COG0765	amino acid transport
EZZ25_RS11530	COG1126	abc transporter atp-binding protein
EZZ25_RS11535	COG0670	Belongs to the BI1 family
EZZ25_RS11540	COG2920	part of a sulfur-relay system
EZZ25_RS11545	COG1254	Belongs to the acylphosphatase family
EZZ25_RS11550	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EZZ25_RS11555	COG3706	GGDEF domain
EZZ25_RS11570	COG4999	Histidine kinase
EZZ25_RS11570	COG3850	Histidine kinase
EZZ25_RS11570	COG3437	response regulator, receiver
EZZ25_RS11570	COG2205	protein histidine kinase activity
EZZ25_RS11575	COG3437	response regulator, receiver
EZZ25_RS11580	COG0625	glutathione transferase activity
EZZ25_RS11590	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
EZZ25_RS11600	COG2195	Cleaves the N-terminal amino acid of tripeptides
EZZ25_RS11630	COG0372	Belongs to the citrate synthase family
EZZ25_RS11635	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
EZZ25_RS11675	COG1566	PFAM secretion protein HlyD family protein
EZZ25_RS11695	COG1129	ABC transporter
EZZ25_RS11725	COG0745	RESPONSE REGULATOR receiver
EZZ25_RS11730	COG2205	protein histidine kinase activity
EZZ25_RS11735	COG3713	MltA-interacting MipA family protein
EZZ25_RS11740	COG2990	Protein conserved in bacteria
EZZ25_RS11750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EZZ25_RS11750	COG4191	Histidine kinase
EZZ25_RS11755	COG0471	metal ion transport
EZZ25_RS11765	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EZZ25_RS11785	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EZZ25_RS11795	COG3768	UPF0283 membrane protein
EZZ25_RS11800	COG3106	COG3106 Predicted ATPase
EZZ25_RS11820	COG0494	nUDIX hydrolase
EZZ25_RS11825	COG0814	amino acid
EZZ25_RS11830	COG1760	l-serine dehydratase
EZZ25_RS11835	COG0720	synthase
EZZ25_RS11845	COG0017	Asparaginyl-tRNA synthetase
EZZ25_RS11850	COG0351	phosphomethylpyrimidine kinase
EZZ25_RS11855	COG2770	Histidine kinase
EZZ25_RS11855	COG3437	response regulator, receiver
EZZ25_RS11860	COG1448	Aminotransferase
EZZ25_RS11875	COG0840	transmembrane signaling receptor activity
EZZ25_RS11880	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
EZZ25_RS11885	COG2943	transferase activity, transferring hexosyl groups
EZZ25_RS11890	COG1609	Transcriptional regulator
EZZ25_RS11895	COG3394	polysaccharide catabolic process
EZZ25_RS11900	COG1486	melibiose metabolic process
EZZ25_RS11905	COG1447	Phosphotransferase system cellobiose-specific component IIA
EZZ25_RS11915	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EZZ25_RS11920	COG0726	polysaccharide deacetylase
EZZ25_RS11925	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EZZ25_RS11930	COG1846	Transcriptional regulator
EZZ25_RS11960	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EZZ25_RS11975	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EZZ25_RS11980	COG3108	Peptidase M15
EZZ25_RS12015	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EZZ25_RS12025	COG2814	Major facilitator Superfamily
EZZ25_RS12035	COG1054	Belongs to the UPF0176 family
EZZ25_RS12045	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EZZ25_RS12050	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EZZ25_RS12055	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EZZ25_RS12100	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
EZZ25_RS12105	COG4139	cobalamin transport
EZZ25_RS12125	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
EZZ25_RS12130	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
EZZ25_RS12135	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EZZ25_RS12140	COG1823	symporter activity
EZZ25_RS12145	COG2925	Exonuclease
EZZ25_RS12150	COG1380	Effector of murein hydrolase LrgA
EZZ25_RS12155	COG1346	cytolysis
EZZ25_RS12195	COG0776	regulation of translation
EZZ25_RS12200	COG0072	phenylalanine-tRNA ligase activity
EZZ25_RS12200	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EZZ25_RS12205	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EZZ25_RS12255	COG0322	excinuclease ABC activity
EZZ25_RS12260	COG2197	response regulator
EZZ25_RS12265	COG0417	DNA replication proofreading
EZZ25_RS12270	COG5001	Diguanylate cyclase
EZZ25_RS12280	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EZZ25_RS12285	COG3099	Belongs to the UPF0263 family
EZZ25_RS12300	COG1228	amidohydrolase
EZZ25_RS12305	COG0010	Belongs to the arginase family
EZZ25_RS12310	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
EZZ25_RS12315	COG2986	histidine ammonia-lyase
EZZ25_RS12335	COG0247	lactate metabolic process
EZZ25_RS12335	COG0277	FAD linked oxidase domain protein
EZZ25_RS12350	COG2885	chlorophyll binding
EZZ25_RS12370	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EZZ25_RS12380	COG0281	malic enzyme
EZZ25_RS12390	COG2949	membrane
EZZ25_RS12400	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EZZ25_RS12410	COG0492	ferredoxin-NADP+ reductase activity
EZZ25_RS12415	COG4988	ABC transporter
EZZ25_RS12420	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EZZ25_RS12425	COG1187	pseudouridine synthase activity
EZZ25_RS12430	COG0009	L-threonylcarbamoyladenylate synthase
EZZ25_RS12435	COG0613	PHP domain protein
EZZ25_RS12445	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EZZ25_RS12450	COG0512	Glutamine amidotransferase of anthranilate synthase
EZZ25_RS12455	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EZZ25_RS12460	COG0134	indole-3-glycerol-phosphate synthase activity
EZZ25_RS12460	COG0135	phosphoribosylanthranilate isomerase activity
EZZ25_RS12465	COG0133	tryptophan synthase activity
EZZ25_RS12470	COG0159	tryptophan synthase activity
EZZ25_RS12480	COG1435	thymidine kinase activity
EZZ25_RS12485	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EZZ25_RS12490	COG1801	Protein of unknown function DUF72
EZZ25_RS12495	COG4106	trans-aconitate 2-methyltransferase activity
EZZ25_RS12500	COG0500	methyltransferase
EZZ25_RS12505	COG4067	protein conserved in archaea
EZZ25_RS12505	COG0189	ligase activity
EZZ25_RS12520	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
EZZ25_RS12530	COG3852	Histidine kinase
EZZ25_RS12545	COG3070	regulator of competence-specific genes
EZZ25_RS12555	COG2431	L-lysine efflux transmembrane transporter activity
EZZ25_RS12565	COG0076	glutamate decarboxylase activity
EZZ25_RS12570	COG1737	Transcriptional regulator
EZZ25_RS12575	COG1012	belongs to the aldehyde dehydrogenase family
EZZ25_RS12575	COG1454	alcohol dehydrogenase
EZZ25_RS12580	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EZZ25_RS12585	COG3273	potassium ion transport
EZZ25_RS12585	COG2985	domain, Protein
EZZ25_RS12590	COG0542	response to heat
EZZ25_RS12595	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
EZZ25_RS12600	COG1278	Cold shock
EZZ25_RS12610	COG1187	pseudouridine synthase activity
EZZ25_RS12615	COG0140	phosphoribosyl-ATP diphosphatase activity
EZZ25_RS12615	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EZZ25_RS12620	COG0107	imidazoleglycerol-phosphate synthase activity
EZZ25_RS12625	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EZZ25_RS12630	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EZZ25_RS12635	COG0131	Imidazoleglycerol-phosphate dehydratase
EZZ25_RS12635	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EZZ25_RS12640	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EZZ25_RS12645	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EZZ25_RS12650	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EZZ25_RS12655	COG1757	Na H antiporter
EZZ25_RS12660	COG2916	Histone family protein nucleoid-structuring protein H-NS
EZZ25_RS12665	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EZZ25_RS12670	COG0482	sulfurtransferase activity
EZZ25_RS12675	COG2915	High frequency lysogenization protein hflD homolog
EZZ25_RS12680	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EZZ25_RS12690	COG2268	Band 7 protein
EZZ25_RS12700	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EZZ25_RS12715	COG0300	oxidoreductase activity
EZZ25_RS12725	COG0501	Belongs to the peptidase M48B family
EZZ25_RS12735	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
EZZ25_RS12740	COG2226	methyltransferase
EZZ25_RS12745	COG0156	8-amino-7-oxononanoate synthase activity
EZZ25_RS12750	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EZZ25_RS12755	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EZZ25_RS12760	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EZZ25_RS12765	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EZZ25_RS12770	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EZZ25_RS12775	COG0653	protein targeting
EZZ25_RS12780	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EZZ25_RS12785	COG2203	Gaf domain
EZZ25_RS12785	COG2199	diguanylate cyclase activity
EZZ25_RS12795	COG4120	Belongs to the binding-protein-dependent transport system permease family
EZZ25_RS12805	COG4628	conserved protein (DUF2132)
EZZ25_RS12810	COG3092	negative regulation of chromosome organization
EZZ25_RS12815	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EZZ25_RS12820	COG0280	phosphate acetyltransferase
EZZ25_RS12820	COG0857	belongs to the CobB CobQ family
EZZ25_RS12825	COG0435	Glutathione S-transferase
EZZ25_RS12830	COG4608	Belongs to the ABC transporter superfamily
EZZ25_RS12835	COG0444	Belongs to the ABC transporter superfamily
EZZ25_RS12840	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EZZ25_RS12845	COG0601	transmembrane transport
EZZ25_RS12865	COG2204	response regulator
EZZ25_RS12870	COG5001	Diguanylate cyclase
EZZ25_RS12870	COG3300	MHYT domain
EZZ25_RS12875	COG4191	Histidine kinase
EZZ25_RS12880	COG5002	protein histidine kinase activity
EZZ25_RS12890	COG2201	protein-glutamate methylesterase activity
EZZ25_RS12905	COG0009	L-threonylcarbamoyladenylate synthase
EZZ25_RS12925	COG1881	PFAM PEBP family protein
EZZ25_RS12950	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EZZ25_RS12955	COG0640	Transcriptional regulator
EZZ25_RS12960	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EZZ25_RS12965	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EZZ25_RS12970	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EZZ25_RS13045	COG1396	sequence-specific DNA binding
EZZ25_RS13070	COG3706	GGDEF domain
EZZ25_RS13090	COG1946	Acyl-CoA thioesterase
EZZ25_RS13095	COG1522	sequence-specific DNA binding
EZZ25_RS13105	COG0616	signal peptide processing
EZZ25_RS13110	COG1028	Short-chain dehydrogenase reductase Sdr
EZZ25_RS13115	COG2983	Belongs to the UPF0260 family
EZZ25_RS13125	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EZZ25_RS13130	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EZZ25_RS13135	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EZZ25_RS13140	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EZZ25_RS13145	COG2832	Protein of unknown function (DUF454)
EZZ25_RS13155	COG0745	RESPONSE REGULATOR receiver
EZZ25_RS13160	COG0583	DNA-binding transcription factor activity
EZZ25_RS13165	COG0778	Nitroreductase
EZZ25_RS13170	COG1024	Enoyl-CoA hydratase
EZZ25_RS13170	COG1250	3-hydroxyacyl-CoA dehydrogenase
EZZ25_RS13175	COG0183	Belongs to the thiolase family
EZZ25_RS13195	COG2067	long-chain fatty acid transport protein
EZZ25_RS13205	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EZZ25_RS13210	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
EZZ25_RS13215	COG2982	Protein involved in outer membrane biogenesis
EZZ25_RS13220	COG0572	uridine kinase
EZZ25_RS13230	COG0489	protein tyrosine kinase activity
EZZ25_RS13235	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EZZ25_RS13235	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EZZ25_RS13245	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
EZZ25_RS13260	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EZZ25_RS13260	COG0517	IMP dehydrogenase activity
EZZ25_RS13260	COG0617	tRNA 3'-terminal CCA addition
EZZ25_RS13265	COG2199	diguanylate cyclase activity
EZZ25_RS13270	COG0314	molybdopterin synthase activity
EZZ25_RS13275	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
EZZ25_RS13280	COG0315	cyclic pyranopterin monophosphate synthase activity
EZZ25_RS13285	COG0521	Mo-molybdopterin cofactor biosynthetic process
EZZ25_RS13290	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EZZ25_RS13295	COG0391	Required for morphogenesis under gluconeogenic growth conditions
EZZ25_RS13300	COG2198	Histidine kinase
EZZ25_RS13305	COG2204	response regulator
EZZ25_RS13315	COG0556	nucleotide-excision repair
EZZ25_RS13325	COG4657	Part of a membrane complex involved in electron transport
EZZ25_RS13330	COG2878	Part of a membrane complex involved in electron transport
EZZ25_RS13335	COG4656	Part of a membrane complex involved in electron transport
EZZ25_RS13340	COG4658	electron transport chain
EZZ25_RS13350	COG4660	Part of a membrane complex involved in electron transport
EZZ25_RS13355	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EZZ25_RS13360	COG0346	lactoylglutathione lyase activity
EZZ25_RS13375	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EZZ25_RS13380	COG2056	Na+-H+ antiporter family
EZZ25_RS13385	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EZZ25_RS13390	COG1286	toxin biosynthetic process
EZZ25_RS13395	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
EZZ25_RS13400	COG0285	dihydrofolate synthase activity
EZZ25_RS13405	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EZZ25_RS13410	COG0101	tRNA pseudouridine synthase activity
EZZ25_RS13425	COG2190	(PTS) system
EZZ25_RS13425	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EZZ25_RS13425	COG1263	PTS System
EZZ25_RS13430	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EZZ25_RS13435	COG1940	carbohydrate kinase activity
EZZ25_RS13435	COG1846	Transcriptional regulator
EZZ25_RS13440	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EZZ25_RS13440	COG4651	solute:proton antiporter activity
EZZ25_RS13445	COG0367	asparagine synthase
EZZ25_RS13460	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EZZ25_RS13465	COG0563	adenylate kinase activity
EZZ25_RS13470	COG0326	Molecular chaperone. Has ATPase activity
EZZ25_RS13475	COG3710	Transcriptional regulator
EZZ25_RS13490	COG0622	Phosphoesterase
EZZ25_RS13495	COG1090	epimerase
EZZ25_RS13500	COG0300	oxidoreductase activity
EZZ25_RS13510	COG3118	belongs to the thioredoxin family
EZZ25_RS13515	COG0330	HflC and HflK could
EZZ25_RS13520	COG1585	Membrane protein implicated in regulation of membrane protease activity
EZZ25_RS13525	COG0789	Transcriptional regulator
EZZ25_RS13540	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EZZ25_RS13545	COG3115	cell septum assembly
EZZ25_RS13550	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
EZZ25_RS13555	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EZZ25_RS13565	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EZZ25_RS13575	COG2190	(PTS) system
EZZ25_RS13580	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EZZ25_RS13585	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EZZ25_RS13590	COG1702	phosphate starvation-inducible protein PhoH
EZZ25_RS13600	COG4535	Mg2 and Co2 transporter CorC
EZZ25_RS13605	COG0815	Transfers the fatty acyl group on membrane lipoproteins
EZZ25_RS13610	COG2888	peptidyl-tyrosine sulfation
EZZ25_RS13615	COG0495	leucyl-tRNA aminoacylation
EZZ25_RS13620	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
EZZ25_RS13625	COG1466	dna polymerase III delta subunit
EZZ25_RS13630	COG0799	negative regulation of ribosome biogenesis
EZZ25_RS13635	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EZZ25_RS13640	COG0768	penicillin binding
EZZ25_RS13645	COG0772	Belongs to the SEDS family
EZZ25_RS13650	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EZZ25_RS13655	COG1686	Belongs to the peptidase S11 family
EZZ25_RS13660	COG2921	Belongs to the UPF0250 family
EZZ25_RS13665	COG0321	lipoyl(octanoyl) transferase activity
EZZ25_RS13670	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EZZ25_RS13680	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EZZ25_RS13705	COG1596	polysaccharide export
EZZ25_RS13715	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EZZ25_RS13745	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
EZZ25_RS13785	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
EZZ25_RS13790	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
EZZ25_RS13795	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EZZ25_RS13800	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EZZ25_RS13825	COG4104	PAAR repeat-containing protein
EZZ25_RS13855	COG0471	metal ion transport
EZZ25_RS13860	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
EZZ25_RS13905	COG0671	phosphoesterase, PA-phosphatase related
EZZ25_RS13910	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
EZZ25_RS13920	COG1999	signal sequence binding
EZZ25_RS13935	COG0786	glutamate:sodium symporter activity
EZZ25_RS13955	COG1566	PFAM secretion protein HlyD family protein
EZZ25_RS13980	COG0813	purine-nucleoside phosphorylase activity
EZZ25_RS13990	COG3272	Protein of unknown function (DUF1722)
EZZ25_RS14000	COG0415	Belongs to the DNA photolyase family
EZZ25_RS14005	COG1376	ErfK ybiS ycfS ynhG family protein
EZZ25_RS14005	COG1388	LysM domain
EZZ25_RS14015	COG0513	Belongs to the DEAD box helicase family
EZZ25_RS14020	COG1770	oligopeptidase
EZZ25_RS14050	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EZZ25_RS14055	COG0573	inorganic phosphate transmembrane transporter activity
EZZ25_RS14060	COG0581	inorganic phosphate transmembrane transporter activity
EZZ25_RS14065	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EZZ25_RS14085	COG3314	Sporulation integral membrane protein YlbJ
EZZ25_RS14090	COG0659	secondary active sulfate transmembrane transporter activity
EZZ25_RS14105	COG0739	heme binding
EZZ25_RS14110	COG5001	Diguanylate cyclase
EZZ25_RS14110	COG3300	MHYT domain
EZZ25_RS14115	COG0583	DNA-binding transcription factor activity
EZZ25_RS14120	COG2814	Major facilitator Superfamily
EZZ25_RS14145	COG1301	dicarboxylic acid transport
EZZ25_RS14155	COG1342	Belongs to the UPF0251 family
EZZ25_RS14190	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EZZ25_RS14195	COG0673	inositol 2-dehydrogenase activity
EZZ25_RS14205	COG2200	EAL domain
EZZ25_RS14205	COG2771	luxR family
EZZ25_RS14210	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EZZ25_RS14220	COG0564	pseudouridine synthase activity
EZZ25_RS14290	COG3829	transcription factor binding
EZZ25_RS14320	COG3501	Rhs element vgr protein
EZZ25_RS14320	COG3409	Peptidoglycan-binding domain 1 protein
EZZ25_RS14335	COG1869	D-ribose catabolic process
EZZ25_RS14340	COG1129	ABC transporter
EZZ25_RS14345	COG1172	Belongs to the binding-protein-dependent transport system permease family
EZZ25_RS14350	COG1879	ABC-type sugar transport system periplasmic component
EZZ25_RS14355	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EZZ25_RS14360	COG1609	Transcriptional regulator
EZZ25_RS14365	COG5002	protein histidine kinase activity
EZZ25_RS14365	COG5001	Diguanylate cyclase
EZZ25_RS14365	COG3447	MASE1 domain protein
EZZ25_RS14375	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
EZZ25_RS14395	COG0584	glycerophosphoryl diester phosphodiesterase
EZZ25_RS14400	COG2271	Major facilitator Superfamily
EZZ25_RS14440	COG0579	oxidoreductase
EZZ25_RS14450	COG0242	peptide deformylase activity
EZZ25_RS14455	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EZZ25_RS14455	COG1017	nitric oxide dioxygenase activity
EZZ25_RS14460	COG1320	monovalent cation:proton antiporter activity
EZZ25_RS14465	COG2212	antiporter activity
EZZ25_RS14470	COG1863	multisubunit Na H antiporter MnhE subunit
EZZ25_RS14475	COG0651	ATP synthesis coupled electron transport
EZZ25_RS14480	COG1006	Multisubunit Na H antiporter MnhC subunit
EZZ25_RS14485	COG2111	Na H antiporter
EZZ25_RS14485	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EZZ25_RS14495	COG0589	response to stress
EZZ25_RS14500	COG0814	amino acid
EZZ25_RS14515	COG3530	Putative quorum-sensing-regulated virulence factor
EZZ25_RS14525	COG5001	Diguanylate cyclase
EZZ25_RS14525	COG5002	protein histidine kinase activity
EZZ25_RS14530	COG1278	Cold shock
EZZ25_RS14545	COG2304	oxidoreductase activity
EZZ25_RS14565	COG0714	Associated with various cellular activities
EZZ25_RS14570	COG0840	transmembrane signaling receptor activity
EZZ25_RS14585	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EZZ25_RS14590	COG2195	Cleaves the N-terminal amino acid of tripeptides
EZZ25_RS14600	COG3604	Transcriptional regulator
EZZ25_RS14605	COG1017	nitric oxide dioxygenase activity
EZZ25_RS14605	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EZZ25_RS14610	COG1278	Cold shock
EZZ25_RS14615	COG3036	rescue of stalled ribosome
EZZ25_RS14640	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
EZZ25_RS14640	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EZZ25_RS14645	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EZZ25_RS14655	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EZZ25_RS14670	COG0516	GMP reductase activity
EZZ25_RS14690	COG0513	Belongs to the DEAD box helicase family
EZZ25_RS14695	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EZZ25_RS14700	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EZZ25_RS14705	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EZZ25_RS14710	COG3437	response regulator, receiver
EZZ25_RS14710	COG0784	Response regulator, receiver
EZZ25_RS14715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EZZ25_RS14715	COG4191	Histidine kinase
EZZ25_RS14725	COG1757	Na H antiporter
EZZ25_RS14730	COG2814	Major facilitator Superfamily
EZZ25_RS14740	COG3706	GGDEF domain
EZZ25_RS14745	COG3240	lipase activity
EZZ25_RS14755	COG0840	transmembrane signaling receptor activity
EZZ25_RS14760	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
EZZ25_RS14765	COG5380	lipid catabolic process
EZZ25_RS14790	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EZZ25_RS14795	COG4605	iron ion homeostasis
EZZ25_RS14800	COG4604	ABC transporter, ATP-binding protein
EZZ25_RS14805	COG2207	Transcriptional regulator
EZZ25_RS14820	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EZZ25_RS14845	COG0745	RESPONSE REGULATOR receiver
EZZ25_RS14855	COG3623	hexulose-6-phosphate isomerase
EZZ25_RS14860	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
EZZ25_RS14865	COG0561	phosphatase activity
EZZ25_RS14900	COG0366	Alpha amylase catalytic
EZZ25_RS14920	COG0745	RESPONSE REGULATOR receiver
EZZ25_RS14925	COG5002	protein histidine kinase activity
EZZ25_RS14950	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EZZ25_RS14965	COG2814	Major facilitator Superfamily
EZZ25_RS14980	COG1686	Belongs to the peptidase S11 family
EZZ25_RS15000	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EZZ25_RS15000	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EZZ25_RS15005	COG0509	glycine decarboxylation via glycine cleavage system
EZZ25_RS15010	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EZZ25_RS15020	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EZZ25_RS15120	COG3772	lysozyme
EZZ25_RS15285	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EZZ25_RS15290	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EZZ25_RS15325	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
EZZ25_RS15330	COG2944	sequence-specific DNA binding
EZZ25_RS15460	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EZZ25_RS15565	COG0494	nUDIX hydrolase
EZZ25_RS15600	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
EZZ25_RS15655	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EZZ25_RS15790	COG0494	nUDIX hydrolase
EZZ25_RS15815	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EZZ25_RS15835	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EZZ25_RS16110	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EZZ25_RS16165	COG0346	lactoylglutathione lyase activity
EZZ25_RS16190	COG1328	CTP reductase activity
EZZ25_RS16195	COG0602	queuosine metabolic process
EZZ25_RS16205	COG0189	ligase activity
EZZ25_RS16205	COG4067	protein conserved in archaea
EZZ25_RS16215	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EZZ25_RS16215	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EZZ25_RS16215	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
EZZ25_RS16220	COG1105	Belongs to the carbohydrate kinase PfkB family
EZZ25_RS16225	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
EZZ25_RS16225	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EZZ25_RS16230	COG1609	Transcriptional regulator
EZZ25_RS16235	COG0420	3'-5' exonuclease activity
EZZ25_RS16240	COG0419	ATPase involved in DNA repair
EZZ25_RS16245	COG0784	Response regulator, receiver
EZZ25_RS16245	COG2205	protein histidine kinase activity
EZZ25_RS16250	COG0156	8-amino-7-oxononanoate synthase activity
EZZ25_RS16260	COG0038	chloride channel
EZZ25_RS16265	COG0523	cobalamin synthesis protein
EZZ25_RS16275	COG3158	transport of potassium into the cell
EZZ25_RS16280	COG1013	pyruvate-flavodoxin oxidoreductase activity
EZZ25_RS16280	COG0674	pyruvate-flavodoxin oxidoreductase activity
EZZ25_RS16280	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EZZ25_RS16280	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EZZ25_RS16285	COG2205	protein histidine kinase activity
EZZ25_RS16295	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EZZ25_RS16300	COG0586	Pfam SNARE associated Golgi protein
EZZ25_RS16310	COG2200	EAL domain
EZZ25_RS16320	COG3038	cytochrome b561
EZZ25_RS16330	COG2116	formate transmembrane transporter activity
EZZ25_RS16335	COG0583	DNA-binding transcription factor activity
EZZ25_RS16345	COG3593	DNA synthesis involved in DNA repair
EZZ25_RS16350	COG0737	Belongs to the 5'-nucleotidase family
EZZ25_RS16365	COG2824	Alkylphosphonate utilization operon protein PhnA
EZZ25_RS16400	COG2199	diguanylate cyclase activity
EZZ25_RS16420	COG3706	GGDEF domain
EZZ25_RS16435	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
EZZ25_RS16440	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
EZZ25_RS16450	COG0745	RESPONSE REGULATOR receiver
EZZ25_RS16465	COG3140	Belongs to the UPF0181 family
EZZ25_RS16470	COG0023	Translation Initiation Factor
EZZ25_RS16490	COG1042	CoA-binding domain protein
EZZ25_RS16490	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EZZ25_RS16490	COG0045	succinate-CoA ligase (ADP-forming) activity
EZZ25_RS16495	COG0583	DNA-binding transcription factor activity
EZZ25_RS16500	COG4771	TonB-dependent receptor
EZZ25_RS16500	COG1629	transport
EZZ25_RS16520	COG2050	protein possibly involved in aromatic compounds catabolism
EZZ25_RS16545	COG0625	glutathione transferase activity
EZZ25_RS16560	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EZZ25_RS16565	COG4172	Belongs to the ABC transporter superfamily
EZZ25_RS16570	COG4239	(ABC) transporter, permease
EZZ25_RS16575	COG4174	ABC transporter (Permease)
EZZ25_RS16580	COG4166	transmembrane transport
EZZ25_RS16605	COG3104	oligopeptide transport
EZZ25_RS16625	COG3842	ATPase activity
EZZ25_RS16630	COG1840	ABC-type Fe3 transport system, periplasmic component
EZZ25_RS16635	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EZZ25_RS16640	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EZZ25_RS16645	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EZZ25_RS16650	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EZZ25_RS16655	COG1011	Hydrolase
EZZ25_RS16665	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
EZZ25_RS16670	COG1970	mechanosensitive ion channel activity
EZZ25_RS16675	COG2759	Belongs to the formate--tetrahydrofolate ligase family
EZZ25_RS16680	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EZZ25_RS16680	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EZZ25_RS16685	COG0302	gtp cyclohydrolase
EZZ25_RS16695	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EZZ25_RS16705	COG2897	thiosulfate sulfurtransferase activity
EZZ25_RS16710	COG2390	Transcriptional regulator
EZZ25_RS16725	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EZZ25_RS16780	COG0583	DNA-binding transcription factor activity
EZZ25_RS16785	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
EZZ25_RS16790	COG0778	Nitroreductase
EZZ25_RS16830	COG0446	pyridine nucleotide-disulphide oxidoreductase
EZZ25_RS16875	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EZZ25_RS16875	COG1263	PTS System
EZZ25_RS16880	COG1609	Transcriptional regulator
EZZ25_RS16885	COG1621	beta-fructofuranosidase activity
EZZ25_RS16890	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EZZ25_RS16895	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EZZ25_RS16905	COG2885	chlorophyll binding
EZZ25_RS16910	COG0545	Peptidyl-prolyl cis-trans isomerase
EZZ25_RS16915	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EZZ25_RS16920	COG0840	transmembrane signaling receptor activity
EZZ25_RS16925	COG3069	C4-dicarboxylate transmembrane transporter activity
EZZ25_RS16930	COG1760	l-serine dehydratase
EZZ25_RS16950	COG1609	Transcriptional regulator
EZZ25_RS16955	COG2197	response regulator
EZZ25_RS16960	COG3850	Histidine kinase
EZZ25_RS16965	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EZZ25_RS16975	COG0243	molybdopterin cofactor binding
EZZ25_RS16995	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
EZZ25_RS17000	COG2197	response regulator
EZZ25_RS17005	COG3851	Histidine kinase
EZZ25_RS17010	COG2271	Major facilitator Superfamily
EZZ25_RS17015	COG1840	ABC-type Fe3 transport system, periplasmic component
EZZ25_RS17025	COG3842	ATPase activity
EZZ25_RS17030	COG3243	poly(R)-hydroxyalkanoic acid synthase
EZZ25_RS17040	COG0183	Belongs to the thiolase family
EZZ25_RS17050	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EZZ25_RS17055	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EZZ25_RS17075	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EZZ25_RS17085	COG1979	alcohol dehydrogenase
EZZ25_RS17100	COG4191	Histidine kinase
EZZ25_RS17110	COG2271	Major facilitator Superfamily
EZZ25_RS17115	COG0469	pyruvate kinase activity
EZZ25_RS17125	COG1879	ABC-type sugar transport system periplasmic component
EZZ25_RS17130	COG1803	Methylglyoxal synthase
EZZ25_RS17135	COG1335	isochorismatase
EZZ25_RS17140	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EZZ25_RS17155	COG0210	DNA helicase
EZZ25_RS17160	COG1289	transmembrane transporter activity
EZZ25_RS17190	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
EZZ25_RS17195	COG4149	molybdate abc transporter
EZZ25_RS17200	COG0725	ABC transporter, periplasmic molybdate-binding protein
EZZ25_RS17205	COG1492	cobalamin metabolic process
EZZ25_RS17240	COG0784	Response regulator, receiver
EZZ25_RS17240	COG5002	protein histidine kinase activity
EZZ25_RS17245	COG1879	ABC-type sugar transport system periplasmic component
EZZ25_RS17255	COG2827	Endonuclease containing a URI domain
EZZ25_RS17270	COG2926	Belongs to the UPF0265 family
EZZ25_RS17290	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EZZ25_RS17295	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EZZ25_RS17300	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
EZZ25_RS17305	COG0247	lactate metabolic process
EZZ25_RS17310	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EZZ25_RS17315	COG3118	belongs to the thioredoxin family
EZZ25_RS17345	COG0583	DNA-binding transcription factor activity
EZZ25_RS17350	COG4160	amino acid transport
EZZ25_RS17355	COG4215	(ABC) transporter
EZZ25_RS17360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EZZ25_RS17365	COG1126	abc transporter atp-binding protein
EZZ25_RS17375	COG2425	protein containing a von Willebrand factor type A (vWA) domain
EZZ25_RS17385	COG0494	nUDIX hydrolase
EZZ25_RS17390	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
EZZ25_RS17400	COG1309	transcriptional regulator
EZZ25_RS17405	COG0513	Belongs to the DEAD box helicase family
EZZ25_RS17410	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
EZZ25_RS17420	COG0814	amino acid
EZZ25_RS17425	COG0840	transmembrane signaling receptor activity
EZZ25_RS17430	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EZZ25_RS17440	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
EZZ25_RS17450	COG1984	allophanate hydrolase subunit 2
EZZ25_RS17465	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
EZZ25_RS17470	COG4181	ATPase activity
EZZ25_RS17480	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EZZ25_RS17485	COG5001	Diguanylate cyclase
EZZ25_RS17485	COG1716	ATPase activity
EZZ25_RS17500	COG0484	heat shock protein binding
EZZ25_RS17515	COG0546	phosphoglycolate phosphatase activity
EZZ25_RS17530	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EZZ25_RS17535	COG1368	sulfuric ester hydrolase activity
EZZ25_RS17545	COG0513	Belongs to the DEAD box helicase family
EZZ25_RS17560	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EZZ25_RS17570	COG3046	protein related to deoxyribodipyrimidine photolyase
EZZ25_RS17575	COG3397	chitin binding
EZZ25_RS17580	COG3227	Zinc metalloprotease (Elastase)
EZZ25_RS17590	COG0010	Belongs to the arginase family
EZZ25_RS17595	COG1166	arginine decarboxylase activity
EZZ25_RS17605	COG2239	Acts as a magnesium transporter
EZZ25_RS17610	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EZZ25_RS17615	COG0459	protein refolding
EZZ25_RS17625	COG0527	aspartate kinase activity
EZZ25_RS17630	COG0662	Cupin 2, conserved barrel domain protein
EZZ25_RS17635	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EZZ25_RS17640	COG0456	acetyltransferase
EZZ25_RS17645	COG2154	pterin-4-alpha-carbinolamine dehydratase
EZZ25_RS17650	COG3186	Phenylalanine-4-hydroxylase
EZZ25_RS17655	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EZZ25_RS17675	COG2264	protein methyltransferase activity
EZZ25_RS17700	COG1253	flavin adenine dinucleotide binding
EZZ25_RS17705	COG1765	OsmC-like protein
EZZ25_RS17735	COG0531	amino acid
EZZ25_RS17750	COG3279	Response regulator of the LytR AlgR family
EZZ25_RS17755	COG3275	phosphorelay sensor kinase activity
EZZ25_RS17770	COG1136	(ABC) transporter
EZZ25_RS17770	COG0577	efflux transmembrane transporter activity
EZZ25_RS17775	COG1136	(ABC) transporter
EZZ25_RS17790	COG4989	oxidoreductase activity
EZZ25_RS17795	COG0366	Alpha amylase catalytic
EZZ25_RS17805	COG2067	long-chain fatty acid transport protein
EZZ25_RS17810	COG2267	carboxylic ester hydrolase activity
EZZ25_RS17820	COG3227	Zinc metalloprotease (Elastase)
EZZ25_RS17830	COG3047	cAMP biosynthetic process
EZZ25_RS17840	COG1686	Belongs to the peptidase S11 family
EZZ25_RS17845	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EZZ25_RS17850	COG1271	oxidase subunit
EZZ25_RS17855	COG1294	oxidase, subunit
EZZ25_RS17870	COG3048	D-serine ammonia-lyase activity
EZZ25_RS17875	COG0583	DNA-binding transcription factor activity
EZZ25_RS17880	COG0582	viral genome integration into host DNA
EZZ25_RS17895	COG1063	alcohol dehydrogenase
EZZ25_RS17930	COG1278	Cold shock
EZZ25_RS17935	COG0557	exoribonuclease II activity
EZZ25_RS18050	COG0798	PFAM Bile acid sodium symporter
EZZ25_RS18055	COG0640	Transcriptional regulator
EZZ25_RS18080	COG1278	Cold shock
EZZ25_RS18105	COG0582	viral genome integration into host DNA
EZZ25_RS18130	COG1063	alcohol dehydrogenase
EZZ25_RS18140	COG2873	o-acetylhomoserine
EZZ25_RS18150	COG0346	lactoylglutathione lyase activity
EZZ25_RS18175	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
EZZ25_RS18180	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EZZ25_RS18185	COG0363	glucosamine-6-phosphate deaminase activity
EZZ25_RS18190	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
EZZ25_RS18215	COG1929	Belongs to the glycerate kinase type-1 family
EZZ25_RS18220	COG2610	gluconate transmembrane transporter activity
EZZ25_RS18225	COG3835	regulator
EZZ25_RS18235	COG0748	coenzyme F420 binding
EZZ25_RS18240	COG3721	Heme iron utilization protein
EZZ25_RS18250	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
EZZ25_RS18255	COG0811	peptide transport
EZZ25_RS18260	COG0848	biopolymer transport protein
EZZ25_RS18265	COG4558	Periplasmic binding protein
EZZ25_RS18270	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EZZ25_RS18275	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
EZZ25_RS18310	COG0633	Ferredoxin
EZZ25_RS18310	COG3217	Mosc domain protein beta barrel domain protein
EZZ25_RS18310	COG3217	Mosc domain protein beta barrel domain protein
EZZ25_RS18310	COG0633	Ferredoxin
EZZ25_RS18315	COG0418	dihydroorotase activity
EZZ25_RS18325	COG3152	Membrane
EZZ25_RS18335	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EZZ25_RS18340	COG2354	Protein conserved in bacteria
EZZ25_RS18345	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
EZZ25_RS18350	COG1278	Cold shock
EZZ25_RS18380	COG2199	diguanylate cyclase activity
EZZ25_RS18385	COG1349	DNA-binding transcription factor activity
EZZ25_RS18400	COG3833	ABC-type maltose transport systems, permease component
EZZ25_RS18405	COG1175	transmembrane transport
EZZ25_RS18415	COG3842	ATPase activity
EZZ25_RS18420	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EZZ25_RS18435	COG0393	Putative heavy-metal-binding
EZZ25_RS18445	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EZZ25_RS18450	COG0835	chemotaxis
EZZ25_RS18450	COG0784	Response regulator, receiver
EZZ25_RS18460	COG3706	GGDEF domain
EZZ25_RS18500	COG0583	DNA-binding transcription factor activity
EZZ25_RS18505	COG5001	Diguanylate cyclase
EZZ25_RS18515	COG1741	Belongs to the pirin family
EZZ25_RS18520	COG3123	guanosine phosphorylase activity
EZZ25_RS18530	COG2211	Major facilitator Superfamily
EZZ25_RS18540	COG0840	transmembrane signaling receptor activity
EZZ25_RS18545	COG1067	ATP-dependent peptidase activity
EZZ25_RS18555	COG4172	Belongs to the ABC transporter superfamily
EZZ25_RS18580	COG0583	DNA-binding transcription factor activity
EZZ25_RS18585	COG1620	l-lactate permease
EZZ25_RS18600	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
EZZ25_RS18610	COG0840	transmembrane signaling receptor activity
EZZ25_RS18620	COG0513	Belongs to the DEAD box helicase family
EZZ25_RS18625	COG0583	DNA-binding transcription factor activity
EZZ25_RS18635	COG1902	pentaerythritol trinitrate reductase activity
EZZ25_RS18645	COG1132	(ABC) transporter
EZZ25_RS18655	COG1902	pentaerythritol trinitrate reductase activity
EZZ25_RS18665	COG1280	lysine exporter protein (LysE YggA)
EZZ25_RS18670	COG2207	Transcriptional regulator
EZZ25_RS18690	COG1846	Transcriptional regulator
EZZ25_RS18695	COG1764	response to oxidative stress
EZZ25_RS18700	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EZZ25_RS18705	COG0697	spore germination
EZZ25_RS18715	COG0700	Nucleoside recognition
EZZ25_RS18720	COG3366	ferrous iron transmembrane transporter activity
EZZ25_RS18725	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EZZ25_RS18735	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EZZ25_RS18740	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
EZZ25_RS18745	COG2259	Doxx family
EZZ25_RS18770	COG0363	glucosamine-6-phosphate deaminase activity
EZZ25_RS18785	COG4580	involved in the transport of maltose and maltodextrins
EZZ25_RS18800	COG0840	transmembrane signaling receptor activity
EZZ25_RS18815	COG0840	transmembrane signaling receptor activity
EZZ25_RS18825	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EZZ25_RS18830	COG1126	abc transporter atp-binding protein
EZZ25_RS18840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EZZ25_RS18845	COG4597	amino acid ABC transporter
EZZ25_RS18850	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EZZ25_RS18855	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
EZZ25_RS18855	COG2213	PTS system mannitol-specific
EZZ25_RS18860	COG0246	Mannitol dehydrogenase
EZZ25_RS18865	COG3722	fumarate hydratase activity
EZZ25_RS18870	COG0673	inositol 2-dehydrogenase activity
EZZ25_RS18895	COG2910	NAD(P)H-binding
EZZ25_RS18905	COG0840	transmembrane signaling receptor activity
EZZ25_RS18910	COG4221	oxidoreductase activity
EZZ25_RS18920	COG1901	pseudouridine methyltransferase
EZZ25_RS18935	COG0531	amino acid
EZZ25_RS18940	COG1982	Orn Lys Arg decarboxylase major
EZZ25_RS18970	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EZZ25_RS18995	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EZZ25_RS19035	COG0745	RESPONSE REGULATOR receiver
EZZ25_RS19060	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EZZ25_RS19065	COG0840	transmembrane signaling receptor activity
EZZ25_RS19070	COG0835	chemotaxis
EZZ25_RS19075	COG0835	chemotaxis
EZZ25_RS19080	COG2198	Histidine kinase
EZZ25_RS19080	COG0643	Histidine kinase
EZZ25_RS19100	COG0601	transmembrane transport
EZZ25_RS19105	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EZZ25_RS19115	COG2194	sulfuric ester hydrolase activity
EZZ25_RS19120	COG0642	Histidine kinase
EZZ25_RS19155	COG1444	tRNA N-acetyltransferase activity
EZZ25_RS19160	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EZZ25_RS19200	COG0217	transcriptional regulatory protein
EZZ25_RS19205	COG2084	Dehydrogenase
EZZ25_RS19225	COG2909	trisaccharide binding
EZZ25_RS19230	COG0058	SHG alpha-glucan phosphorylase activity
EZZ25_RS19235	COG1640	4-alpha-glucanotransferase
EZZ25_RS19240	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position