locus-tag class description GPY01_RS00005 ENOG4105CQZ Histidine kinase GPY01_RS00020 ENOG4105CXY transporter GPY01_RS00025 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase GPY01_RS00035 ENOG4108I5U Uridine phosphorylase GPY01_RS00040 ENOG4106Z1T Nicotinamide Mononucleotide Transporter GPY01_RS00045 ENOG4105ETE Transcriptional regulator (LacI family GPY01_RS00050 ENOG4108RVA ribokinase GPY01_RS00055 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator GPY01_RS00060 ENOG4105CNN ABC, transporter GPY01_RS00065 ENOG4105C2J ABC transporter GPY01_RS00070 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) GPY01_RS00090 ENOG4105CS6 Rhs element vgr protein GPY01_RS00120 ENOG4108JUB Transcriptional regulator GPY01_RS00125 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GPY01_RS00185 ENOG4105D3G Pseudouridine synthase GPY01_RS00195 ENOG4107VXZ Hydrolase GPY01_RS00200 ENOG4105BZU Histidine kinase GPY01_RS00210 ENOG4105D9R oxidoreductase GPY01_RS00215 ENOG4107RH7 Nicotinate phosphoribosyltransferase GPY01_RS00255 ENOG4105CK2 sodium dicarboxylate symporter GPY01_RS00275 ENOG4108Z4X TRANSCRIPTIONal GPY01_RS00280 ENOG4105E5M Multidrug resistance protein D GPY01_RS00285 ENOG4105EQ2 LysR family Transcriptional regulator GPY01_RS00290 ENOG4105BZU Histidine kinase GPY01_RS00295 ENOG4105DR5 peptidase GPY01_RS00305 ENOG4105CHH sulfate transporter GPY01_RS00310 ENOG4105DWD nucleoside recognition domain protein GPY01_RS00320 ENOG4105BZU Histidine kinase GPY01_RS00325 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) GPY01_RS00330 ENOG4105E2Z phosphate ABC transporter (Permease GPY01_RS00335 ENOG4105C8U phosphate abc transporter GPY01_RS00340 ENOG4105CVA phosphate GPY01_RS00365 ENOG4105CUG Oligopeptidase b GPY01_RS00370 ENOG4105C1J atp-dependent rna helicase GPY01_RS00380 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein GPY01_RS00385 ENOG4105CVP deoxyribo-dipyrimidine photolyase GPY01_RS00395 ENOG4107SEY Conserved Protein GPY01_RS00400 ENOG4105D3A purine nucleoside phosphorylase DeoD-type GPY01_RS00415 ENOG4106TD9 Diguanylate cyclase GPY01_RS00420 ENOG4105VNT transposase (IS4 family) protein GPY01_RS00435 ENOG4105YE1 PilZ domain GPY01_RS00440 ENOG4105D6U Sodium Glutamate Symporter GPY01_RS00465 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) GPY01_RS00470 ENOG4105EYK Phosphatidylglycerophosphatase B GPY01_RS00490 ENOG4105C8Q Methyl-accepting chemotaxis GPY01_RS00515 ENOG4108Q67 UPF0319 protein GPY01_RS00520 ENOG4105C8P )-transporter GPY01_RS00530 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) GPY01_RS00555 ENOG4105CS6 Rhs element vgr protein GPY01_RS00560 ENOG4108WC9 type VI secretion system effector, hcp1 family GPY01_RS00565 ENOG4108RS6 transposase GPY01_RS00575 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) GPY01_RS00580 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) GPY01_RS00585 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) GPY01_RS00590 ENOG41061ZR Transcriptional regulator GPY01_RS00595 ENOG4108YYI Protein of unknown function (DUF2810) GPY01_RS00605 ENOG4105C8Q Methyl-accepting chemotaxis GPY01_RS00610 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase GPY01_RS00615 ENOG4105CDY transcriptional regulatory protein GPY01_RS00645 ENOG4106RMF ParB family GPY01_RS00650 ENOG4107RUE extracellular solute-binding protein family 1 GPY01_RS00655 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) GPY01_RS00685 ENOG4105XJC Two component transcriptional regulator (Winged helix family GPY01_RS00690 ENOG4105DHQ Histidine kinase GPY01_RS00695 ENOG4105DIJ Phosphoethanolamine transferase GPY01_RS00700 ENOG4108JQ6 ABC transporter GPY01_RS00705 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GPY01_RS00710 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GPY01_RS00725 ENOG4108VYJ response regulator receiver protein GPY01_RS00735 ENOG4108V3W Chemotaxis protein, CheW GPY01_RS00740 ENOG4108V3W Chemotaxis protein, CheW GPY01_RS00745 ENOG4105C8Q Methyl-accepting chemotaxis GPY01_RS00755 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) GPY01_RS00760 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) GPY01_RS00775 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GPY01_RS00785 ENOG4108JJA ABC, transporter GPY01_RS00800 ENOG4107QZV Type I secretion membrane fusion protein GPY01_RS00805 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) GPY01_RS00815 ENOG4105E6M Sulphatase-modifying factor protein GPY01_RS00830 ENOG4105C26 Dehydrogenase GPY01_RS00840 ENOG4105CK7 Sodium proline symporter GPY01_RS00850 ENOG4105C8Q Methyl-accepting chemotaxis GPY01_RS00855 ENOG4105EW9 transcriptional regulator AsnC family GPY01_RS00860 ENOG4107RGH Aldehyde dehydrogenase GPY01_RS00870 ENOG4105CXN decarboxylase GPY01_RS00875 ENOG4105D5Q Arginine ornithine antiporter GPY01_RS00885 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) GPY01_RS00895 ENOG4105JQN Transcriptional regulator GPY01_RS00900 ENOG4105EMU Dehydrogenase GPY01_RS00905 ENOG41069D7 Methyl-accepting chemotaxis GPY01_RS00910 ENOG4105JQN Transcriptional regulator GPY01_RS00915 ENOG4108RYK Nad-dependent epimerase dehydratase GPY01_RS00940 ENOG4108KTG Membrane protein, drug metabolite transporter GPY01_RS00965 ENOG4105EP9 oxidoreductase GPY01_RS00970 ENOG4105E61 Mannitol repressor protein GPY01_RS00975 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase GPY01_RS00980 ENOG4105CTS PTS system mannitol-specific GPY01_RS00985 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain GPY01_RS00990 ENOG4105EZ7 amino acid ABC transporter GPY01_RS00995 ENOG4106TNF Periplasmic binding protein GPY01_RS01005 ENOG4105CDA abc transporter atp-binding protein GPY01_RS01010 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) GPY01_RS01020 ENOG4105C8Q Methyl-accepting chemotaxis GPY01_RS01030 ENOG4108N3W hemolysin secretion protein GPY01_RS01045 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) GPY01_RS01050 ENOG4107W52 maltose operon periplasmic protein GPY01_RS01060 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) GPY01_RS01085 ENOG4108VGI doxx family GPY01_RS01090 ENOG4105D03 DNA-3-methyladenine glycosylase II GPY01_RS01095 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GPY01_RS01105 ENOG4105DN9 Na H antiporter GPY01_RS01110 ENOG41074DU domain protein GPY01_RS01115 ENOG4108P2H Inner membrane protein YjiG GPY01_RS01120 ENOG4105VW4 glutaredoxin 3 GPY01_RS01125 ENOG4108SXK Transporter Drug Metabolite Exporter family GPY01_RS01135 ENOG4108ZHJ Organic hydroperoxide resistance protein GPY01_RS01140 ENOG4105K56 Transcriptional regulator GPY01_RS01175 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GPY01_RS01185 ENOG4105BZ1 (ABC) transporter GPY01_RS01200 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) GPY01_RS01205 ENOG4105ECQ AraC Family Transcriptional Regulator GPY01_RS01210 ENOG4105C1J atp-dependent rna helicase GPY01_RS01220 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor GPY01_RS01230 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) GPY01_RS01240 ENOG4105DMF Dehydrogenase GPY01_RS01245 ENOG4105DAA L-lactate GPY01_RS01250 ENOG4105CC0 LysR family Transcriptional regulator GPY01_RS01265 ENOG4107SDU Methyl-accepting chemotaxis GPY01_RS01275 ENOG4108JQ5 ABC transporter GPY01_RS01285 ENOG4105DAN ATP-dependent protease GPY01_RS01290 ENOG4105C8Q Methyl-accepting chemotaxis GPY01_RS01300 ENOG4105E5W Transporter GPY01_RS01310 ENOG4105NBK UPF0345 protein GPY01_RS01315 ENOG4105EUB pirin domain protein GPY01_RS01325 ENOG4108K0B C-di-gmp phosphodiesterase GPY01_RS01330 ENOG4105ETT transcriptional Regulator, LysR family GPY01_RS01350 ENOG4105BZU Histidine kinase GPY01_RS01365 ENOG4106TD9 Diguanylate cyclase GPY01_RS01370 ENOG4105K56 Transcriptional regulator GPY01_RS01375 ENOG4107R88 Chemotaxis protein (CheV) GPY01_RS01380 ENOG4105KQ5 peptidylprolyl cis-trans isomerase GPY01_RS01385 ENOG41086KC Transcriptional regulator GPY01_RS01390 ENOG4105K8R UPF0145 protein GPY01_RS01405 ENOG4108HK0 -acetyltransferase GPY01_RS01410 ENOG4108IJ9 (ABC) transporter GPY01_RS01415 ENOG4107FKK extracellular solute-binding protein family 1 GPY01_RS01420 ENOG4105D56 permease protein GPY01_RS01425 ENOG4105EG2 ABC transporter, permease GPY01_RS01440 ENOG4105E98 transcriptional regulator DeoR family GPY01_RS01470 ENOG4105VEQ Cold shock protein GPY01_RS01475 ENOG4108ESY Metal dependent phosphohydrolase GPY01_RS01480 ENOG4105CKW Inner membrane protein yedI GPY01_RS01485 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) GPY01_RS01495 ENOG4105KAF membrAne GPY01_RS01505 ENOG4105EKE dihydroorotase GPY01_RS01510 ENOG4105QVC MOSC domain-containing protein GPY01_RS01510 ENOG4105QVC MOSC domain-containing protein GPY01_RS01515 ENOG4105C8Q Methyl-accepting chemotaxis GPY01_RS01545 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) GPY01_RS01550 ENOG4105EHG Permease protein GPY01_RS01555 ENOG4107R4I Periplasmic binding protein GPY01_RS01560 ENOG4106GFD transport protein GPY01_RS01565 ENOG41090AP transport protein GPY01_RS01570 ENOG4105WQ5 TonB family GPY01_RS01575 ENOG4105D4P Coproporphyrinogen iii oxidase GPY01_RS01580 ENOG41090JE Utilization Protein GPY01_RS01585 ENOG4105PYN Pyridoxamine 5-phosphate oxidase-related GPY01_RS01590 ENOG4108NVR Methyl-accepting chemotaxis GPY01_RS01595 ENOG4105BZW Glycerate kinase GPY01_RS01620 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) GPY01_RS01625 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) GPY01_RS01630 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase GPY01_RS01635 ENOG4105DHT Metal Dependent Phosphohydrolase GPY01_RS01640 ENOG4107SSZ Phosphatase GPY01_RS01660 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase GPY01_RS01665 ENOG4105EXG Transcriptional regulator GPY01_RS01670 ENOG4108IQK o-acetylhomoserine GPY01_RS01675 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) GPY01_RS01680 ENOG4105CPQ Dehydrogenase GPY01_RS01730 ENOG4105W8I Transcriptional regulator GPY01_RS01735 ENOG4105BZC d-serine deaminase GPY01_RS01750 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii GPY01_RS01755 ENOG4105C4M (Ubiquinol oxidase) subunit I GPY01_RS01760 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GPY01_RS01765 ENOG41061WM D-Alanyl-D-Alanine GPY01_RS01780 ENOG4105D4Y metalloprotease GPY01_RS01790 ENOG4108M0H Extracellular lipase GPY01_RS01795 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation GPY01_RS01805 ENOG4107T9C Alpha amylase catalytic region GPY01_RS01810 ENOG4107RGM aldo keto reductase GPY01_RS01825 ENOG4105DVH amino acid GPY01_RS01855 ENOG4107YWA deoxycytidylate deaminase GPY01_RS01860 ENOG4108UKZ OsmC family GPY01_RS01865 ENOG4105C37 (CBS) domain GPY01_RS01870 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) GPY01_RS01885 ENOG4105EGI Transcriptional regulator GPY01_RS01890 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) GPY01_RS01905 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GPY01_RS01910 ENOG4105MIR Phenylalanine 4-monooxygenase GPY01_RS01915 ENOG41090A4 Pterin carbinolamine dehydratase GPY01_RS01920 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase GPY01_RS01925 ENOG4108JPW Aminotransferase GPY01_RS01930 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) GPY01_RS01935 ENOG4105CZK Aspartate kinase GPY01_RS01945 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) GPY01_RS01950 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) GPY01_RS01955 ENOG4105CJW magnesium transporter GPY01_RS01970 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) GPY01_RS01985 ENOG4105D4Y metalloprotease GPY01_RS02005 ENOG4105CVA phosphate GPY01_RS02015 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) GPY01_RS02020 ENOG4105C1J atp-dependent rna helicase GPY01_RS02030 ENOG4107RE1 Inosine-guanosine kinase GPY01_RS02045 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) GPY01_RS02060 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) GPY01_RS02080 ENOG4105RKW reductase (By GPY01_RS02090 ENOG4108I0Y (ABC) transporter GPY01_RS02095 ENOG4105CV6 ABC transporter, permease GPY01_RS02100 ENOG4105C6Y Udp-glucose 6-dehydrogenase GPY01_RS02110 ENOG4107R7A Allophanate hydrolase subunit 2 GPY01_RS02120 ENOG4105E7W lamb ycsf family protein GPY01_RS02125 ENOG4105CMR udp-glucose 4-epimerase GPY01_RS02130 ENOG4108N3W hemolysin secretion protein GPY01_RS02135 ENOG4105E0U tyrosine-specific transport protein GPY01_RS02145 ENOG4108ZYK Acyl carrier protein phosphodiesterase GPY01_RS02150 ENOG4105C1J atp-dependent rna helicase GPY01_RS02155 ENOG4108IG5 Transcriptional regulator GPY01_RS02160 ENOG4106RE7 Cytochrome GPY01_RS02165 ENOG4105C5W Aldolase GPY01_RS02170 ENOG4108YZ4 nudix hydrolase GPY01_RS02180 ENOG4105EV2 VWA domain protein interacting with AAA ATPase GPY01_RS02190 ENOG4105E5Z arginine transporter ATP-binding subunit GPY01_RS02195 ENOG4106PMH Extracellular solute-binding protein family 3 GPY01_RS02200 ENOG4105GBT ABC transporter GPY01_RS02205 ENOG4105DMR ABC, transporter GPY01_RS02230 ENOG4105K63 Thioredoxin GPY01_RS02235 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GPY01_RS02240 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) GPY01_RS02245 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B GPY01_RS02250 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A GPY01_RS02255 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) GPY01_RS02285 ENOG4108YXG UPF0502 protein GPY01_RS02290 ENOG41082IR Excinuclease ABC C subunit domain protein GPY01_RS02300 ENOG4108QGH periplasmic GPY01_RS02305 ENOG4105BZU Histidine kinase GPY01_RS02335 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) GPY01_RS02340 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein GPY01_RS02345 ENOG4105E0C molybdate abc transporter GPY01_RS02350 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) GPY01_RS02380 ENOG4105EM2 membrane GPY01_RS02385 ENOG41088T4 Helicase IV GPY01_RS02390 ENOG41080IJ Diacylglycerol kinase GPY01_RS02395 ENOG4108RWI nicotinamidase GPY01_RS02400 ENOG4108Z5K methylglyoxal synthase GPY01_RS02405 ENOG4108SV3 Tmao reductase system periplasmic protein tort GPY01_RS02410 ENOG4105BZU Histidine kinase GPY01_RS02415 ENOG4105CA9 Pyruvate kinase GPY01_RS02420 ENOG4105CXY transporter GPY01_RS02425 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC GPY01_RS02435 ENOG4107TXD phosphoglycerate transport system transcriptional regulatory protein pgta GPY01_RS02445 ENOG4108I6A alcohol dehydrogenase GPY01_RS02455 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) GPY01_RS02460 ENOG4105BZU Histidine kinase GPY01_RS02475 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GPY01_RS02480 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GPY01_RS02490 ENOG4105CHU acetyl-coa acetyltransferase GPY01_RS02500 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class GPY01_RS02505 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GPY01_RS02510 ENOG4107RCV ABC transporter, permease GPY01_RS02515 ENOG4105C4Y ABC transporter GPY01_RS02520 ENOG4105CXY transporter GPY01_RS02525 ENOG4105BZU Histidine kinase GPY01_RS02530 ENOG4108KX4 response regulator GPY01_RS02535 ENOG4105DHT Metal Dependent Phosphohydrolase GPY01_RS02555 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) GPY01_RS02570 ENOG4105BZU Histidine kinase GPY01_RS02575 ENOG4105WH1 Two component transcriptional regulator luxr family GPY01_RS02580 ENOG4105EJQ L-serine dehydratase GPY01_RS02585 ENOG4105CEE C4-dicarboxylate transporter GPY01_RS02595 ENOG4107VXZ Hydrolase GPY01_RS02600 ENOG4108V1T peptidylprolyl cis-trans isomerase GPY01_RS02605 ENOG4105CDV Ompa motb domain protein GPY01_RS02610 ENOG4108NVR Methyl-accepting chemotaxis GPY01_RS02615 ENOG4105C6V Glycerol-3-phosphate dehydrogenase GPY01_RS02620 ENOG4105D7K pfkb domain protein GPY01_RS02625 ENOG4107R3K hydrolase GPY01_RS02630 ENOG4105ETE Transcriptional regulator (LacI family GPY01_RS02635 ENOG4105C5Y PTS System GPY01_RS02680 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase GPY01_RS02690 ENOG41080HT Transcriptional regulator, arsr family GPY01_RS02715 ENOG4108RCM Nitroreductase GPY01_RS02720 ENOG41067V3 Antibiotic biosynthesis monooxygenase GPY01_RS02725 ENOG4105ETT transcriptional Regulator, LysR family GPY01_RS02735 ENOG4105RA2 Membrane GPY01_RS02750 ENOG4108M3J Dehydrogenase GPY01_RS02775 ENOG4105CV1 Transketolase (EC 2.2.1.1) GPY01_RS02780 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) GPY01_RS02790 ENOG4107RHR regulatoR GPY01_RS02800 ENOG4105KHC sulfurtransferase GPY01_RS02810 ENOG4105D06 uba thif-type nad fad binding protein GPY01_RS02815 ENOG4105CVM Molybdenum cofactor synthesis domain protein GPY01_RS02820 ENOG4105EUJ GTP cyclohydrolase i GPY01_RS02825 ENOG4105E0X reductase GPY01_RS02830 ENOG4105CKU formyltetrahydrofolate synthetase GPY01_RS02835 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) GPY01_RS02840 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain GPY01_RS02850 ENOG4105JQN Transcriptional regulator GPY01_RS02855 ENOG4105PAD Hydrolase GPY01_RS02875 ENOG4105EG2 ABC transporter, permease GPY01_RS02895 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) GPY01_RS02905 ENOG4108IJ9 (ABC) transporter GPY01_RS02915 ENOG4105NXH GreA GreB family elongation factor GPY01_RS02920 ENOG4108KAZ Involved in phosphonate degradation (By similarity) GPY01_RS02925 ENOG4108JPW Aminotransferase GPY01_RS02930 ENOG4107STF Involved in phosphonate degradation (By similarity) GPY01_RS02960 ENOG4105DUX Transporter GPY01_RS02985 ENOG4105E43 Extracellular solute-binding protein, family 5 GPY01_RS02990 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component GPY01_RS02995 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component GPY01_RS03000 ENOG4108JQ5 ABC transporter GPY01_RS03005 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) GPY01_RS03020 ENOG4105CYM Glutathione S-transferase GPY01_RS03040 ENOG4105KA0 thioesterase Superfamily protein GPY01_RS03055 ENOG4105D05 Receptor GPY01_RS03060 ENOG4105CWB LysR family transcriptional Regulator GPY01_RS03065 ENOG4105CD5 CoA-binding domain protein GPY01_RS03075 ENOG4105CPF Cell wall formation (By similarity) GPY01_RS03085 ENOG4108ZJT translation initiation factor, Sui1 GPY01_RS03105 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GPY01_RS03115 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) GPY01_RS03120 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) GPY01_RS03135 ENOG4105BZU Histidine kinase GPY01_RS03145 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) GPY01_RS03155 ENOG4105BZU Histidine kinase GPY01_RS03190 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA GPY01_RS03205 ENOG4105DU1 integral membrane protein, terc GPY01_RS03210 ENOG4105CGH 5'-nucleotidase GPY01_RS03215 ENOG4105CPB ATP-dependent endonuclease of the OLD family GPY01_RS03220 ENOG4108UQ5 membrane protein YcdZ GPY01_RS03225 ENOG4105DUM transcriptional regulator, lysR family GPY01_RS03230 ENOG4105TMB Formate nitrite transporter GPY01_RS03240 ENOG4105DS1 cytochrome b561 GPY01_RS03250 ENOG4105EPM Diguanylate phosphodiesterase GPY01_RS03260 ENOG4108RHM integral membrane protein GPY01_RS03265 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) GPY01_RS03270 ENOG4105EEX Two component transcriptional regulator (Winged helix family GPY01_RS03280 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) GPY01_RS03290 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) GPY01_RS03295 ENOG4105CKI cobalamin synthesis protein GPY01_RS03300 ENOG4105CMQ Chloride channel GPY01_RS03310 ENOG4107KBT 8-Amino-7-oxononanoate synthase GPY01_RS03315 ENOG4108MGY Histidine kinase GPY01_RS03320 ENOG4105EYH Exonuclease GPY01_RS03325 ENOG4107RFY SbcCD D subunit GPY01_RS03330 ENOG4107B7Y DNA-binding transcriptional regulator FruR GPY01_RS03335 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein GPY01_RS03340 ENOG4105DE4 1-phosphofructokinase GPY01_RS03345 ENOG4105DM4 PTS System GPY01_RS03350 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) GPY01_RS03355 ENOG4105CGF Aromatic amino acid aminotransferase GPY01_RS03360 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) GPY01_RS03365 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase GPY01_RS03470 ENOG4108MK9 spermidine N(1)-acetyltransferase GPY01_RS03485 ENOG410600T transposase GPY01_RS03495 ENOG410600T transposase GPY01_RS03630 ENOG4105VDM plasmid maintenance system antidote protein, xre family GPY01_RS03635 ENOG41080ET plasmid maintenance system killer protein GPY01_RS03675 ENOG4105W08 virulence gene repressor rsal GPY01_RS03680 ENOG4105W2W Cytotoxic translational repressor of toxin-antitoxin stability system GPY01_RS03700 ENOG4108S58 Phenazine biosynthesis protein PhzF GPY01_RS03775 ENOG410600T transposase GPY01_RS03850 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein GPY01_RS03890 ENOG4105QNF Outer membrane lipoprotein GPY01_RS04040 ENOG4105D70 Integrase catalytic subunit GPY01_RS04045 ENOG4105F5W AtP-binding protein GPY01_RS04055 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) GPY01_RS04060 ENOG41082NX 50s ribosomal protein l35 GPY01_RS04065 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) GPY01_RS04070 ENOG4105C22 threonyL-tRNA synthetase GPY01_RS04075 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) GPY01_RS04085 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) GPY01_RS04090 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) GPY01_RS04095 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor GPY01_RS04100 ENOG4108UHE carbonic anhydrase GPY01_RS04115 ENOG4105DZ1 carboxypeptidase GPY01_RS04125 ENOG4105C8Q Methyl-accepting chemotaxis GPY01_RS04150 ENOG4108IJF Heavy metal efflux pump, CzcA GPY01_RS04165 ENOG4105BZU Histidine kinase GPY01_RS04170 ENOG4105XJC Two component transcriptional regulator (Winged helix family GPY01_RS04215 ENOG410667J hydrolase GPY01_RS04225 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase GPY01_RS04235 ENOG4105ETX regulatoR GPY01_RS04260 ENOG4105C8Q Methyl-accepting chemotaxis GPY01_RS04270 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) GPY01_RS04290 ENOG4108IPW abc transporter atp-binding protein GPY01_RS04295 ENOG4105CM4 permease protein GPY01_RS04300 ENOG4105DHS permease protein GPY01_RS04320 ENOG4107G87 m6 family metalloprotease domain protein GPY01_RS04330 ENOG4107IFA Lipase (EC 3.1.1.3) GPY01_RS04335 ENOG4108N3W hemolysin secretion protein GPY01_RS04340 ENOG4106M3D hemolysin GPY01_RS04345 ENOG4105KUU lipolytic protein G-D-S-L family GPY01_RS04350 ENOG4105BZU Histidine kinase GPY01_RS04360 ENOG4105E5M Multidrug resistance protein D GPY01_RS04365 ENOG4107S6Z Na H antiporter GPY01_RS04375 ENOG4105BZU Histidine kinase GPY01_RS04380 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase GPY01_RS04385 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) GPY01_RS04390 ENOG4107RA1 nh(3)-dependent nad( ) synthetase GPY01_RS04395 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter GPY01_RS04400 ENOG4105C1J atp-dependent rna helicase GPY01_RS04420 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) GPY01_RS04430 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) GPY01_RS04450 ENOG4105C5I Dehydrogenase GPY01_RS04455 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) GPY01_RS04465 ENOG4108UNF response regulator GPY01_RS04485 ENOG4105VEQ Cold shock protein GPY01_RS04490 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) GPY01_RS04495 ENOG4108JUA Transcriptional regulator GPY01_RS04505 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) GPY01_RS04510 ENOG4105D9N nucleoside GPY01_RS04525 ENOG41069D7 Methyl-accepting chemotaxis GPY01_RS04530 ENOG4105C7R Atpase associated with various cellular activities aaa_3 GPY01_RS04550 ENOG4107QVM von Willebrand factor, type A GPY01_RS04565 ENOG4105VEQ Cold shock protein GPY01_RS04570 ENOG4105BZU Histidine kinase GPY01_RS04580 ENOG4105VRT cytoplasmic protein GPY01_RS04590 ENOG4105C0F tryptophanase EC 4.1.99.1 GPY01_RS04595 ENOG4105CIC tryptophan-specific transport protein GPY01_RS04600 ENOG4105Q9Y Universal stress protein GPY01_RS04610 ENOG4105MKQ Monovalent cation H antiporter subunit C GPY01_RS04615 ENOG4108JPZ Monovalent cation H antiporter subunit D GPY01_RS04620 ENOG4105SC1 monovalent cation H antiporter subunit E GPY01_RS04625 ENOG41080TA Multiple resistance and ph regulation protein f GPY01_RS04630 ENOG4105KJM monovalent cation h antiporter subunit g GPY01_RS04640 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GPY01_RS04650 ENOG4105D5U fad dependent oxidoreductase GPY01_RS04670 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GPY01_RS04680 ENOG4108JQ7 (ABC) transporter GPY01_RS04695 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase GPY01_RS04705 ENOG4107R11 Transcriptional regulator GPY01_RS04715 ENOG4105DCF alanine dehydrogenase GPY01_RS04720 ENOG4105EW9 transcriptional regulator AsnC family GPY01_RS04730 ENOG4105CNU cell division protein FtsK GPY01_RS04735 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) GPY01_RS04740 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) GPY01_RS04745 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) GPY01_RS04755 ENOG4108NVR Methyl-accepting chemotaxis GPY01_RS04760 ENOG4105K59 histidine triad (HIT) protein GPY01_RS04790 ENOG4105CEP NADH dehydrogenase GPY01_RS04800 ENOG4106M3D hemolysin GPY01_RS04810 ENOG4108JA2 transcriptioN-repair coupling factor GPY01_RS04820 ENOG4105D60 lipoprotein releasing system transmembrane protein GPY01_RS04825 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) GPY01_RS04830 ENOG4105D60 lipoprotein releasing system transmembrane protein GPY01_RS04845 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 GPY01_RS04850 ENOG4105BZ1 (ABC) transporter GPY01_RS04855 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) GPY01_RS04865 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) GPY01_RS04870 ENOG4105ED1 spovr family GPY01_RS04875 ENOG4106AKX UPF0229 protein GPY01_RS04880 ENOG4105CYN Serine protein kinase GPY01_RS04885 ENOG4105VNT transposase (IS4 family) protein GPY01_RS04890 ENOG4105XWI UPF0304 protein GPY01_RS04900 ENOG4105F1A Pyruvate formate-lyase GPY01_RS04905 ENOG4108N3W hemolysin secretion protein GPY01_RS04915 ENOG4105C6N Formate acetyltransferase GPY01_RS04930 ENOG4108JEH abc transporter atp-binding protein GPY01_RS04935 ENOG4105E89 ABC transporter GPY01_RS04940 ENOG4105DSP amino acid AbC transporter GPY01_RS04945 ENOG4106YG3 ABC transporter GPY01_RS04950 ENOG4105CGK Exodeoxyribonuclease III GPY01_RS04955 ENOG4105C8Q Methyl-accepting chemotaxis GPY01_RS04960 ENOG4106428 Protein of unknown function (DUF2496) GPY01_RS04965 ENOG4108URS primosomal replication protein n'' GPY01_RS04970 ENOG4105EJ9 Membrane GPY01_RS04975 ENOG4105DVT helicase GPY01_RS04980 ENOG4105ZU8 porin-like protein H GPY01_RS04995 ENOG4105D58 Diguanylate phosphodiesterase GPY01_RS05000 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) GPY01_RS05005 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) GPY01_RS05010 ENOG4105C8N cysteinyl-tRNA synthetase GPY01_RS05015 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) GPY01_RS05020 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) GPY01_RS05025 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) GPY01_RS05030 ENOG4105C4M (Ubiquinol oxidase) subunit I GPY01_RS05035 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii GPY01_RS05045 ENOG4105KJB cyd operon protein YbgE GPY01_RS05050 ENOG4107YD3 Thioesterase GPY01_RS05055 ENOG4105E02 MotA TolQ exbB proton channel GPY01_RS05060 ENOG4105M8F Biopolymer transport protein exbD tolR GPY01_RS05070 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) GPY01_RS05075 ENOG4105KCK Peptidoglycan-associated lipoprotein GPY01_RS05085 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) GPY01_RS05095 ENOG4105BZU Histidine kinase GPY01_RS05100 ENOG4108RNS Exports L-alanine (By similarity) GPY01_RS05105 ENOG4105C26 Dehydrogenase GPY01_RS05110 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family GPY01_RS05115 ENOG4105VYA Uncharacterized conserved protein (DUF2132) GPY01_RS05175 ENOG4108YGG dna repair protein GPY01_RS05225 ENOG4108WC9 type VI secretion system effector, hcp1 family GPY01_RS05235 ENOG4107SV5 CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) GPY01_RS05240 ENOG4107IIZ CRISPR-associated helicase, Cas3 GPY01_RS05265 ENOG4105DFP Integrase GPY01_RS05280 ENOG4105ENT Efflux transporter rnd family, mfp subunit GPY01_RS05290 ENOG4105DY2 Paraquat-inducible protein b GPY01_RS05295 ENOG4105F1S paraquat-inducible protein a GPY01_RS05300 ENOG4108R86 Transcriptional regulator GPY01_RS05305 ENOG4105C26 Dehydrogenase GPY01_RS05310 ENOG4105MTM Protein of unknown function (DUF1496) GPY01_RS05320 ENOG41067SE Tetr family transcriptional regulator GPY01_RS05325 ENOG4107QPN acyl-Coa dehydrogenase GPY01_RS05335 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) GPY01_RS05340 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate GPY01_RS05345 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) GPY01_RS05355 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase GPY01_RS05360 ENOG4105RKX Protein of unknown function (DUF2498) GPY01_RS05365 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) GPY01_RS05370 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) GPY01_RS05375 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) GPY01_RS05395 ENOG4105HP8 regulator of competence-specific genes GPY01_RS05400 ENOG4105ETE Transcriptional regulator (LacI family GPY01_RS05410 ENOG4106WF9 DNA-binding transcriptional regulator TorR GPY01_RS05415 ENOG4107S90 membrAne GPY01_RS05420 ENOG4106371 Methyltransferase GPY01_RS05425 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) GPY01_RS05430 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) GPY01_RS05435 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) GPY01_RS05440 ENOG4105EW9 transcriptional regulator AsnC family GPY01_RS05450 ENOG4105CCT upf0313 protein GPY01_RS05455 ENOG4105BZU Histidine kinase GPY01_RS05475 ENOG4105DZ2 Transcriptional regulator GPY01_RS05480 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) GPY01_RS05490 ENOG4105K9H YciI-like protein GPY01_RS05495 ENOG4105NAU thioesterase Superfamily protein GPY01_RS05500 ENOG4107835 probably involved in intracellular septation (By similarity) GPY01_RS05510 ENOG4105GFG DUF218 domain GPY01_RS05515 ENOG4108535 NAD dependent epimerase/dehydratase family GPY01_RS05525 ENOG4105TMB Formate nitrite transporter GPY01_RS05545 ENOG4107QY8 reductase GPY01_RS05560 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase GPY01_RS05575 ENOG4108JQ2 peptide transport system atp-binding protein GPY01_RS05580 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein GPY01_RS05585 ENOG4108EU3 peptide transport system, permease GPY01_RS05590 ENOG4108I5W peptide transport system, permease protein GPY01_RS05595 ENOG4108J59 Extracellular solute-binding protein, family 5 GPY01_RS05600 ENOG4105E51 psp operon transcriptional activator GPY01_RS05605 ENOG41087YS Phage shock protein A GPY01_RS05620 ENOG4105C1P efflux transporter, rnd family, mfp subunit GPY01_RS05635 ENOG4108R3E Dna-3-methyladenine glycosylase i GPY01_RS05640 ENOG4105Q9Y Universal stress protein GPY01_RS05650 ENOG4105C28 cystathionine GPY01_RS05660 ENOG4105C8J )-transporter GPY01_RS05665 ENOG4108W1A pseudouridine synthase GPY01_RS05670 ENOG4108T9J Cdp-alcohol phosphatidyltransferase GPY01_RS05675 ENOG4108VGW abc transporter atp-binding protein GPY01_RS05680 ENOG4105CXZ ABC transporter, permease GPY01_RS05685 ENOG4105VNH ABC transporter solute-binding protein GPY01_RS05695 ENOG4105XZD Fe-S protein GPY01_RS05705 ENOG4107QWP ABC-2 type transporter GPY01_RS05710 ENOG4105CJ1 ABC, transporter GPY01_RS05720 ENOG4105C44 Serine transporter GPY01_RS05730 ENOG4105CJW magnesium transporter GPY01_RS05750 ENOG4105BZU Histidine kinase GPY01_RS05760 ENOG4105KXC Collagenase GPY01_RS05800 ENOG4108N3W hemolysin secretion protein GPY01_RS05815 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) GPY01_RS05820 ENOG4105BZU Histidine kinase GPY01_RS05835 ENOG4105CFI type iii restriction protein res subunit GPY01_RS05840 ENOG4105I08 Pseudouridine synthase GPY01_RS05845 ENOG4105C2C drug resistance transporter, Bcr CflA GPY01_RS05855 ENOG4105CGD Nad-dependent epimerase dehydratase GPY01_RS05860 ENOG4105UQX Mate efflux family protein GPY01_RS05865 ENOG4108I0Y (ABC) transporter GPY01_RS05880 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) GPY01_RS05890 ENOG4105E3Q saccharopine dehydrogenase GPY01_RS05895 ENOG4105D3D Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine (By similarity) GPY01_RS05900 ENOG4105CDV Ompa motb domain protein GPY01_RS05905 ENOG4105DFG type I secretion outer membrane protein GPY01_RS05925 ENOG4105F04 LysR family Transcriptional regulator GPY01_RS05935 ENOG4108VKG metal-dependent hydrolase GPY01_RS05950 ENOG41090FY type IV pilus biogenesis stability protein PilW GPY01_RS05955 ENOG4105CVG Homoserine O-transsuccinylase GPY01_RS05975 ENOG4107V40 secretion protein, HlyD family GPY01_RS05990 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism GPY01_RS05995 ENOG4106YYS transcriptional regulatory protein GPY01_RS06005 ENOG4107R88 Chemotaxis protein (CheV) GPY01_RS06025 ENOG4105BZU Histidine kinase GPY01_RS06050 ENOG4105F0Z galactose-1-phosphate uridylyltransferase GPY01_RS06055 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) GPY01_RS06060 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) GPY01_RS06065 ENOG4106TD9 Diguanylate cyclase GPY01_RS06070 ENOG4105BZU Histidine kinase GPY01_RS06080 ENOG4105C7K acetolactate synthase GPY01_RS06085 ENOG4107FQX Alpha-acetolactate decarboxylase GPY01_RS06100 ENOG4108TWJ NADH dehydrogenase subunit 5 GPY01_RS06105 ENOG4105DUM transcriptional regulator, lysR family GPY01_RS06125 ENOG4105V0I UPF0267 protein GPY01_RS06140 ENOG4105C9Q fumarate hydratase class II GPY01_RS06150 ENOG4105C4M (Ubiquinol oxidase) subunit I GPY01_RS06155 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii GPY01_RS06160 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) GPY01_RS06165 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GPY01_RS06170 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GPY01_RS06180 ENOG4107QZV Type I secretion membrane fusion protein GPY01_RS06190 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) GPY01_RS06195 ENOG4105CS2 ec 3.2.1.21 GPY01_RS06200 ENOG4105DDV Transcriptional regulator (LacI family GPY01_RS06205 ENOG4105M4H endoribonuclease L-psp GPY01_RS06210 ENOG4105XEP YhcH YjgK YiaL family protein GPY01_RS06215 ENOG4107VXM glycerophosphoryl diester phosphodiesterase GPY01_RS06220 ENOG4105E98 transcriptional regulator DeoR family GPY01_RS06225 ENOG4108IJ9 (ABC) transporter GPY01_RS06230 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component GPY01_RS06260 ENOG4109015 Biopolymer transport protein exbD tolR GPY01_RS06265 ENOG41067XB TonB family GPY01_RS06285 ENOG4107QI1 Mate efflux family protein GPY01_RS06295 ENOG4105FGM Fructosamine kinase GPY01_RS06305 ENOG4107TT5 NLP P60 protein GPY01_RS06310 ENOG4105C8Q Methyl-accepting chemotaxis GPY01_RS06320 ENOG4106IUH DTW domain containing protein GPY01_RS06325 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) GPY01_RS06335 ENOG4105CVM Molybdenum cofactor synthesis domain protein GPY01_RS06340 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) GPY01_RS06345 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GPY01_RS06350 ENOG4107A5B Binding-protein-dependent transport systems, inner membrane component GPY01_RS06360 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GPY01_RS06365 ENOG4105BZU Histidine kinase GPY01_RS06370 ENOG4105C5H ABC transporter GPY01_RS06375 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) GPY01_RS06395 ENOG4109039 Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) GPY01_RS06405 ENOG4108IEG Formate dehydrogenase Alpha subunit GPY01_RS06405 ENOG4108IEG Formate dehydrogenase Alpha subunit GPY01_RS06410 ENOG4105QAX Iron-sulfur GPY01_RS06425 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) GPY01_RS06435 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) GPY01_RS06450 ENOG4105QNR S1 RNA binding domain protein GPY01_RS06455 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B GPY01_RS06460 ENOG4105DY2 Paraquat-inducible protein b GPY01_RS06465 ENOG4105H2K paraquat-inducible protein a GPY01_RS06470 ENOG4105BZ1 (ABC) transporter GPY01_RS06475 ENOG4108ZGC gaf domain protein GPY01_RS06480 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) GPY01_RS06485 ENOG4105CN1 protease GPY01_RS06495 ENOG4105CD8 aminopeptidase N GPY01_RS06505 ENOG4105C7I Dehydrogenase GPY01_RS06510 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) GPY01_RS06515 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) GPY01_RS06520 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) GPY01_RS06530 ENOG4105C5H ABC transporter GPY01_RS06545 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) GPY01_RS06550 ENOG4105DAN ATP-dependent protease GPY01_RS06555 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) GPY01_RS06620 ENOG4105EUK rtx toxin RtxA GPY01_RS06625 ENOG4108RC6 RTX toxin GPY01_RS06650 ENOG4105BZU Histidine kinase GPY01_RS06665 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i GPY01_RS06680 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) GPY01_RS06690 ENOG4105C59 p-type ATPase GPY01_RS06705 ENOG4105DS0 Transcriptional regulator, Crp Fnr family GPY01_RS06710 ENOG4105Q9Y Universal stress protein GPY01_RS06715 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) GPY01_RS06735 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GPY01_RS06740 ENOG4105F38 ABC transporter, permease GPY01_RS06745 ENOG4105D38 putrescine abc transporter GPY01_RS06750 ENOG4107RUE extracellular solute-binding protein family 1 GPY01_RS06755 ENOG4107RUE extracellular solute-binding protein family 1 GPY01_RS06770 ENOG4105BZG amino acid carrier protein GPY01_RS06775 ENOG410829K Lysine exporter protein (Lyse ygga) GPY01_RS06795 ENOG4105CS6 Rhs element vgr protein GPY01_RS06800 ENOG4108WC9 type VI secretion system effector, hcp1 family GPY01_RS06805 ENOG4105CTD carboxy-peptidase GPY01_RS06810 ENOG4105C8Q Methyl-accepting chemotaxis GPY01_RS06815 ENOG4105C0R drug resistance transporter emrb qaca subfamily GPY01_RS06820 ENOG4105CW7 secretion protein, HlyD family GPY01_RS06825 ENOG4105ENJ RND efflux system, outer membrane lipoprotein GPY01_RS06835 ENOG4105C1J atp-dependent rna helicase GPY01_RS06840 ENOG4107SDU Methyl-accepting chemotaxis GPY01_RS06845 ENOG4105C8Q Methyl-accepting chemotaxis GPY01_RS06855 ENOG4105KPY Small multidrug resistance protein GPY01_RS06860 ENOG4105CVP deoxyribo-dipyrimidine photolyase GPY01_RS06865 ENOG4105C0R drug resistance transporter emrb qaca subfamily GPY01_RS06870 ENOG4105EJC lysr family transcriptional regulator GPY01_RS06880 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) GPY01_RS06885 ENOG4105R8A Heat shock protein GPY01_RS06895 ENOG4105CQ7 ATP-dependent helicase GPY01_RS06920 ENOG4105BZU Histidine kinase GPY01_RS06930 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB GPY01_RS06935 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB GPY01_RS06950 ENOG4105BZU Histidine kinase GPY01_RS06970 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) GPY01_RS06975 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) GPY01_RS06980 ENOG410667J hydrolase GPY01_RS06990 ENOG4107QXX ABC transporter GPY01_RS06995 ENOG4105EZ7 amino acid ABC transporter GPY01_RS07000 ENOG4105DRP amino acid AbC transporter GPY01_RS07005 ENOG4105CDA abc transporter atp-binding protein GPY01_RS07010 ENOG4108MN8 Membrane GPY01_RS07015 ENOG4108Z0T Part of a sulfur-relay system (By similarity) GPY01_RS07020 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 GPY01_RS07025 ENOG4105DR4 Methyltransferase GPY01_RS07030 ENOG4106TD9 Diguanylate cyclase GPY01_RS07045 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase GPY01_RS07050 ENOG4108RXX maleylacetoacetate isomerase GPY01_RS07060 ENOG4105F1J Homogentisate 1,2-dioxygenase GPY01_RS07065 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase GPY01_RS07070 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) GPY01_RS07085 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GPY01_RS07090 ENOG4105C7F AcnD-accessory protein PrpF GPY01_RS07095 ENOG4108I0Z Aconitate hydratase GPY01_RS07100 ENOG4105BZN citrate synthase GPY01_RS07105 ENOG4105CR4 methylisocitrate lyase GPY01_RS07140 ENOG4107SDZ Galactoside transport system permease protein mglC GPY01_RS07145 ENOG4105C2J ABC transporter GPY01_RS07170 ENOG4107EXC regulatoR GPY01_RS07175 ENOG4105GR3 Histidine kinase GPY01_RS07180 ENOG4105RW8 MltA-interacting MipA family protein GPY01_RS07185 ENOG4108MJ5 VirK protein GPY01_RS07190 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GPY01_RS07195 ENOG4108TQ9 Histidine kinase GPY01_RS07200 ENOG4105C8P )-transporter GPY01_RS07205 ENOG4108NVR Methyl-accepting chemotaxis GPY01_RS07210 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) GPY01_RS07225 ENOG4105D9U N-acetyltransferase GPY01_RS07230 ENOG4108JU8 Transcriptional regulator GPY01_RS07240 ENOG4105CM6 amino acid regulated cytosolic protein GPY01_RS07255 ENOG4105CRQ synthase (Component I) GPY01_RS07260 ENOG4105P8F nudix hydrolase GPY01_RS07265 ENOG4105C44 Serine transporter GPY01_RS07270 ENOG4105EJQ L-serine dehydratase GPY01_RS07275 ENOG4105DJY efflux transporter, rnd family, mfp subunit GPY01_RS07280 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GPY01_RS07290 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase GPY01_RS07295 ENOG4108NVR Methyl-accepting chemotaxis GPY01_RS07300 ENOG4105C5S asparaginyl-tRNA synthetase GPY01_RS07310 ENOG4105CGF Aromatic amino acid aminotransferase GPY01_RS07325 ENOG4105C8Q Methyl-accepting chemotaxis GPY01_RS07330 ENOG4105DJ9 glucan biosynthesis protein GPY01_RS07335 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) GPY01_RS07340 ENOG41060NJ transcriptional regulator GPY01_RS07345 ENOG410901P UPF0249 protein GPY01_RS07350 ENOG4105F8D glycoside hydrolase family 4 GPY01_RS07355 ENOG4105VCP PTS System GPY01_RS07365 ENOG4105VZJ PTS System GPY01_RS07375 ENOG4105C94 Transporter GPY01_RS07380 ENOG41067TZ transcriptional regulator, MarR family GPY01_RS07395 ENOG4105CG6 trap dicarboxylate transporter dctm subunit GPY01_RS07405 ENOG4105CH5 extracellular solute-binding protein, family 7 GPY01_RS07420 ENOG4105C5X domain protein GPY01_RS07425 ENOG4105EAQ (twin-arginine translocation) pathway signal GPY01_RS07455 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) GPY01_RS07465 ENOG4105S8Q sugar efflux transporter GPY01_RS07475 ENOG4105C72 UPF0176 protein GPY01_RS07480 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GPY01_RS07485 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) GPY01_RS07490 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GPY01_RS07495 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GPY01_RS07500 ENOG4107QK7 reductase GPY01_RS07525 ENOG4105C8Q Methyl-accepting chemotaxis GPY01_RS07540 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) GPY01_RS07545 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) GPY01_RS07560 ENOG4108YZT Adenosylcobinamide kinase GPY01_RS07565 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) GPY01_RS07570 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) GPY01_RS07575 ENOG4105E0X reductase GPY01_RS07580 ENOG4108ETY sodium dicarboxylate symporter GPY01_RS07585 ENOG4105CJB Exodeoxyribonuclease I GPY01_RS07595 ENOG41067MG lrgb family GPY01_RS07600 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) GPY01_RS07620 ENOG4105FQ6 thiopurine methyltransferase GPY01_RS07635 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) GPY01_RS07640 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) GPY01_RS07645 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) GPY01_RS07655 ENOG4105BZU Histidine kinase GPY01_RS07685 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) GPY01_RS07690 ENOG4105WH1 Two component transcriptional regulator luxr family GPY01_RS07695 ENOG4105CQ2 DNA polymerase GPY01_RS07700 ENOG4105BZU Histidine kinase GPY01_RS07710 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) GPY01_RS07725 ENOG4105CZE histidine utilization repressor GPY01_RS07730 ENOG4105CI2 imidazolone-5-propionate hydrolase GPY01_RS07735 ENOG41088SP formiminoglutamate hydrolase GPY01_RS07740 ENOG4105CGP Urocanate hydratase GPY01_RS07745 ENOG4105C84 Histidine ammonia-lyase GPY01_RS07755 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap GPY01_RS07765 ENOG4105CQB FAD linked oxidase domain protein GPY01_RS07780 ENOG4108ZG0 Ompa motb domain protein GPY01_RS07800 ENOG4105C8V SAICAR synthetase GPY01_RS07810 ENOG4107R1I NAD-dependent malic enzyme GPY01_RS07820 ENOG4107GZ4 SanA protein GPY01_RS07825 ENOG4105BZU Histidine kinase GPY01_RS07830 ENOG4105C9B Cysteine desulfurase GPY01_RS07840 ENOG4105C3M thioredoxin reductase GPY01_RS07845 ENOG4108JJ9 ABC, transporter GPY01_RS07850 ENOG4108JJ8 (ABC) transporter GPY01_RS07855 ENOG4105FE9 pseudouridine synthase GPY01_RS07860 ENOG4107RTD sua5 ycio yrdc ywlc family protein GPY01_RS07865 ENOG4105DB7 PHP domain protein GPY01_RS07875 ENOG4105CRQ synthase (Component I) GPY01_RS07880 ENOG4105DDQ anthranilate synthase GPY01_RS07885 ENOG4108I0Q anthranilate phosphoribosyltransferase GPY01_RS07890 ENOG4105DK0 Indole-3-glycerol phosphate synthase GPY01_RS07895 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) GPY01_RS07900 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) GPY01_RS07905 ENOG4105CK2 sodium dicarboxylate symporter GPY01_RS07910 ENOG4107104 thymidine kinase GPY01_RS07915 ENOG4105C9M aspartyl-trna synthetase GPY01_RS07920 ENOG41081XQ Conserved Protein GPY01_RS07925 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) GPY01_RS07930 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) GPY01_RS07935 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) GPY01_RS07950 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) GPY01_RS07960 ENOG4105CUX Signal transduction histidine kinase GPY01_RS07985 ENOG4105DWU Membrane GPY01_RS07995 ENOG4105DY8 decarboxylase GPY01_RS08000 ENOG4106KNT transcriptional regulator GPY01_RS08005 ENOG4108EKI Dehydrogenase GPY01_RS08010 ENOG41090BQ Glutaredoxin GPY01_RS08020 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GPY01_RS08025 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) GPY01_RS08030 ENOG4105VEQ Cold shock protein GPY01_RS08040 ENOG4108R99 pseudouridine synthase GPY01_RS08045 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase GPY01_RS08050 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) GPY01_RS08055 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase GPY01_RS08060 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) GPY01_RS08065 ENOG4105ECC imidazole-glycerol-phosphate dehydratase GPY01_RS08070 ENOG4105CIH Imidazole acetol-phosphate transaminase GPY01_RS08075 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) GPY01_RS08080 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) GPY01_RS08085 ENOG4107S6Z Na H antiporter GPY01_RS08095 ENOG4107RE1 Inosine-guanosine kinase GPY01_RS08100 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) GPY01_RS08105 ENOG41075W9 High frequency lysogenization protein HflD homolog GPY01_RS08110 ENOG4107QTF adenylosuccinate lyase GPY01_RS08120 ENOG4105RHG GPY01_RS08130 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase GPY01_RS08145 ENOG4107FW0 short-chain dehydrogenase reductase GPY01_RS08155 ENOG4105D0M Protease HtpX homolog GPY01_RS08165 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) GPY01_RS08170 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) GPY01_RS08175 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) GPY01_RS08180 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) GPY01_RS08185 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GPY01_RS08190 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) GPY01_RS08195 ENOG4105D1H recombination factor protein RarA GPY01_RS08205 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving GPY01_RS08210 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) GPY01_RS08215 ENOG4105BZU Histidine kinase GPY01_RS08220 ENOG4105VNT transposase (IS4 family) protein GPY01_RS08230 ENOG4108JJB ABC transporter GPY01_RS08235 ENOG4105C7J ABC transporter, permease GPY01_RS08245 ENOG4105VYA Uncharacterized conserved protein (DUF2132) GPY01_RS08250 ENOG4105PQ6 UPF0208 membrane protein GPY01_RS08255 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) GPY01_RS08260 ENOG4108DNC Involved in acetate metabolism (By similarity) GPY01_RS08265 ENOG4105CHF Glutathione S-transferase GPY01_RS08270 ENOG4108JQ7 (ABC) transporter GPY01_RS08275 ENOG4105C3U ABC transporter GPY01_RS08280 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GPY01_RS08285 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GPY01_RS08290 ENOG4107QSI ABC, transporter GPY01_RS08305 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GPY01_RS08310 ENOG4105BZU Histidine kinase GPY01_RS08315 ENOG4105BZU Histidine kinase GPY01_RS08320 ENOG4105BZU Histidine kinase GPY01_RS08330 ENOG4107YTP response regulator receiver protein GPY01_RS08345 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GPY01_RS08365 ENOG4108V1U phospholipid-binding protein GPY01_RS08390 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase GPY01_RS08395 ENOG41082YX Transcriptional regulator, arsr family GPY01_RS08405 ENOG4105BZU Histidine kinase GPY01_RS08425 ENOG4105C29 acyl-CoA thioesterase GPY01_RS08430 ENOG4108XM1 transcriptional regulator AsnC family GPY01_RS08440 ENOG4105ERU peptidase GPY01_RS08445 ENOG4105UBK short-chain dehydrogenase reductase GPY01_RS08465 ENOG4105KRS Proteinase inhibitor GPY01_RS08470 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) GPY01_RS08475 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) GPY01_RS08480 ENOG4107QMP dna polymerase iii subunits gamma and tau GPY01_RS08485 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) GPY01_RS08490 ENOG4105WD1 Membrane GPY01_RS08500 ENOG4105I93 response regulator GPY01_RS08505 ENOG4105EJC lysr family transcriptional regulator GPY01_RS08510 ENOG41069NU Nitroreductase GPY01_RS08515 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GPY01_RS08520 ENOG4105CHU acetyl-coa acetyltransferase GPY01_RS08535 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation GPY01_RS08540 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation GPY01_RS08550 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase GPY01_RS08555 ENOG4108GAE asmA family GPY01_RS08560 ENOG4105DBI uridine monophosphokinase GPY01_RS08565 ENOG4105D1F ATP-binding protein GPY01_RS08570 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) GPY01_RS08580 ENOG4108I5U Uridine phosphorylase GPY01_RS08595 ENOG4105BZU Histidine kinase GPY01_RS08600 ENOG4108ZAF Molybdopterin GPY01_RS08605 ENOG4105M00 molybdopterin converting factor, subunit 1 GPY01_RS08610 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GPY01_RS08615 ENOG4108RIR Molybdenum cofactor biosynthesis protein GPY01_RS08620 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GPY01_RS08625 ENOG4105CHW UPF0052 protein GPY01_RS08635 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GPY01_RS08640 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) GPY01_RS08655 ENOG4108R3D Electron transport complex GPY01_RS08665 ENOG4105D6A Electron transport complex GPY01_RS08670 ENOG4108UQQ Electron transport complex GPY01_RS08675 ENOG4105DZB Electron transport complex GPY01_RS08680 ENOG4105CSM endonuclease III GPY01_RS08685 ENOG4108UYE Lactoylglutathione lyase GPY01_RS08690 ENOG4106WH9 Protein of unknown function (DUF2753) GPY01_RS08695 ENOG4105EIY sodium-type flagellar protein motY GPY01_RS08700 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) GPY01_RS08705 ENOG4105D3Y Na H antiporter GPY01_RS08710 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase GPY01_RS08715 ENOG4105E96 Colicin v production protein GPY01_RS08720 ENOG4108S3P Sporulation domain protein GPY01_RS08725 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase GPY01_RS08730 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) GPY01_RS08735 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) GPY01_RS08745 ENOG4105CX6 glutaminyL-tRNA synthetase GPY01_RS08750 ENOG4105CI1 PTS System GPY01_RS08755 ENOG4105CE4 GlcNAc 6-P deacetylase GPY01_RS08760 ENOG4105E2R ROK family GPY01_RS08765 ENOG4105CKD glutathione-regulated potassium-efflux system protein GPY01_RS08770 ENOG4105CAQ asparagine synthetase GPY01_RS08775 ENOG4105MDZ Transcriptional activator rfaH GPY01_RS08780 ENOG4105DUX Transporter GPY01_RS08785 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) GPY01_RS08790 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) GPY01_RS08795 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) GPY01_RS08800 ENOG4108TU9 TRANSCRIPTIONal GPY01_RS08815 ENOG4108RE9 Phosphodiesterase GPY01_RS08820 ENOG4105ECP epimerase GPY01_RS08825 ENOG4105E1F short-chain dehydrogenase reductase GPY01_RS08835 ENOG4107QR8 Thioredoxin GPY01_RS08840 ENOG4107QX8 SPFH domain, Band 7 family protein GPY01_RS08845 ENOG4105G5H Membrane GPY01_RS08850 ENOG4108Z6Z Transcriptional regulator GPY01_RS08860 ENOG41081QG Porin Gram-negative type GPY01_RS08865 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) GPY01_RS08870 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) GPY01_RS08875 ENOG4105EXN Sulfate transport protein CysZ GPY01_RS08880 ENOG4105C6T cysteine synthase GPY01_RS08890 ENOG4105KZ7 phosphocarrier protein hpr GPY01_RS08900 ENOG4105C5Y PTS System GPY01_RS08905 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family GPY01_RS08910 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) GPY01_RS08915 ENOG4105C9A Phoh family GPY01_RS08920 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) GPY01_RS08925 ENOG4108JU5 Magnesium and cobalt efflux protein GPY01_RS08930 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) GPY01_RS08935 ENOG4107PAI alpha helical protein GPY01_RS08940 ENOG4105C8T Leucyl-tRNA synthetase GPY01_RS08945 ENOG4108U2H Rare lipoprotein B GPY01_RS08950 ENOG4105DJF DNA polymerase III, delta' subunit GPY01_RS08955 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) GPY01_RS08960 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) GPY01_RS08965 ENOG4105CJN penicillin-binding protein GPY01_RS08970 ENOG4105CNI cell division protein FtsW GPY01_RS08975 ENOG4105K6T rare lipoprotein A GPY01_RS08980 ENOG4105DZ1 carboxypeptidase GPY01_RS08985 ENOG4108Z43 UPF0250 protein GPY01_RS08990 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) GPY01_RS08995 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) GPY01_RS09005 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) GPY01_RS09025 ENOG4105D75 Capsular exopolysaccharide family GPY01_RS09030 ENOG4105DAY polysaccharide export protein GPY01_RS09040 ENOG4105D3Q Sugar transferase GPY01_RS09055 ENOG4108MA4 Peptidase M66 GPY01_RS09070 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family GPY01_RS09080 ENOG4105Q84 sucrose synthase GPY01_RS09090 ENOG4105D7W serine acetyltransferase GPY01_RS09110 ENOG4108UW5 maltose o-acetyltransferase GPY01_RS09120 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase GPY01_RS09125 ENOG4107ZF2 Phosphatase GPY01_RS09130 ENOG4105BZS acriflavin resistance protein GPY01_RS09160 ENOG4105CG3 alpha amylase, catalytic region GPY01_RS09165 ENOG4105C5Y PTS System GPY01_RS09170 ENOG4105D4X repressor GPY01_RS09175 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase GPY01_RS09180 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) GPY01_RS09185 ENOG4108UMI ABC transporter, permease GPY01_RS09190 ENOG4105D01 (LipO)protein GPY01_RS09195 ENOG4105EXF Zn-ribbon-containing, possibly nucleic-acid-binding protein GPY01_RS09200 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) GPY01_RS09205 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) GPY01_RS09215 ENOG4105BZU Histidine kinase GPY01_RS09220 ENOG4105EWT decarboxylase family GPY01_RS09225 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease GPY01_RS09230 ENOG4105M08 Membrane GPY01_RS09235 ENOG4105ETT transcriptional Regulator, LysR family GPY01_RS09240 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) GPY01_RS09245 ENOG4106VK6 Flagellar motor protein GPY01_RS09250 ENOG4105E14 MotA TolQ exbB proton channel GPY01_RS09260 ENOG4105CTB Polyprenyl synthetase GPY01_RS09265 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) GPY01_RS09270 ENOG4105DR9 pseudouridine synthase GPY01_RS09275 ENOG4105WP7 tRNA pseudouridine synthase C GPY01_RS09290 ENOG4108428 Inherit from COG: -acetyltransferase GPY01_RS09300 ENOG4108UPT UPF0178 protein GPY01_RS09305 ENOG4105CFC Transporter GPY01_RS09315 ENOG4105NRA 50s ribosomal protein l31 type b GPY01_RS09320 ENOG4108R96 Methyltransferase, YaeB family GPY01_RS09325 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) GPY01_RS09345 ENOG4107QIK phosphoribosylformylglycinamidine synthase GPY01_RS09355 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) GPY01_RS09360 ENOG4108Z6B deaminase GPY01_RS09365 ENOG4105CFC Transporter GPY01_RS09400 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) GPY01_RS09405 ENOG4105CFG Acts as a chaperone (By similarity) GPY01_RS09410 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ GPY01_RS09415 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) GPY01_RS09420 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) GPY01_RS09425 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) GPY01_RS09430 ENOG4105VDB UPF0125 protein GPY01_RS09435 ENOG4108Z1B Cyclase dehydrase GPY01_RS09440 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) GPY01_RS09450 ENOG4105DFP Integrase GPY01_RS09465 ENOG4105DZX CRISPR-associated protein, Csy2 family GPY01_RS09480 ENOG4107SV5 CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) GPY01_RS09490 ENOG4108WC9 type VI secretion system effector, hcp1 family GPY01_RS09545 ENOG4105D70 Integrase catalytic subunit GPY01_RS09550 ENOG4105F5W AtP-binding protein GPY01_RS09570 ENOG4105CFI type iii restriction protein res subunit GPY01_RS09585 ENOG4105DZ0 fad dependent oxidoreductase GPY01_RS09590 ENOG4108Z4U Ferredoxin GPY01_RS09605 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase GPY01_RS09610 ENOG4105YGP holo-ACP synthase CitX GPY01_RS09615 ENOG4105CHY citrate lyase, alpha GPY01_RS09620 ENOG4105CI0 Citrate lyase GPY01_RS09625 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) GPY01_RS09630 ENOG4105DUA (citrate (pro-3S)-lyase ligase GPY01_RS09645 ENOG4107QSA Oxaloacetate decarboxylase GPY01_RS09650 ENOG4105D9Q decarboxylase (Beta subunit) GPY01_RS09655 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism GPY01_RS09660 ENOG4106YYS transcriptional regulatory protein GPY01_RS09680 ENOG4105MWK D-amino acid dehydrogenase, small subunit GPY01_RS09685 ENOG4105BZG amino acid carrier protein GPY01_RS09690 ENOG4108TSE Transferase GPY01_RS09695 ENOG4105E0A ABC, transporter GPY01_RS09700 ENOG4105TVJ transport system, permease GPY01_RS09705 ENOG4105DQ5 transport system permease protein GPY01_RS09710 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein GPY01_RS09720 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase GPY01_RS09725 ENOG4105E4F Isochorismate synthase GPY01_RS09730 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase GPY01_RS09735 ENOG4105WQI isochorismatase GPY01_RS09740 ENOG4106HK8 GPR1 FUN34 yaaH family protein GPY01_RS09750 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) GPY01_RS09755 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) GPY01_RS09760 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) GPY01_RS09775 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) GPY01_RS09780 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) GPY01_RS09785 ENOG4105N21 Membrane GPY01_RS09790 ENOG4105CUT histidyl-tRNA synthetase GPY01_RS09795 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) GPY01_RS09810 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) GPY01_RS09815 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) GPY01_RS09820 ENOG4105WVQ Fe-S assembly protein IscX GPY01_RS09825 ENOG4108ZIT Ferredoxin, 2FE-2S GPY01_RS09840 ENOG4108Z4V iron-sulfur cluster assembly GPY01_RS09845 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins GPY01_RS09855 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family GPY01_RS09860 ENOG4105CVS RNA methyltransferase TrmH family, group 1 GPY01_RS09865 ENOG4105ECY inositol monophosphatase GPY01_RS09870 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GPY01_RS09875 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GPY01_RS09880 ENOG4105VIE preprotein translocase, subunit YajC GPY01_RS09885 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) GPY01_RS09890 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) GPY01_RS09895 ENOG4105W87 Cbs domain GPY01_RS09900 ENOG4108I9X Isocitrate lyase GPY01_RS09905 ENOG4107QP3 malate synthase g GPY01_RS09910 ENOG4105C5Q Transcriptional regulator GPY01_RS09915 ENOG4105D3R alkyl hydroperoxide reductase GPY01_RS09920 ENOG4106N3A copper homeostasis protein cutc GPY01_RS09925 ENOG4105CSR polyphosphate kinase 2 GPY01_RS09935 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) GPY01_RS09940 ENOG4105E2Z phosphate ABC transporter (Permease GPY01_RS09945 ENOG4105C8U phosphate abc transporter GPY01_RS09950 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) GPY01_RS09955 ENOG4105C9X ppx gppa phosphatase GPY01_RS09965 ENOG4105BZU Histidine kinase GPY01_RS09970 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GPY01_RS09975 ENOG4105DH7 May be involved in recombination (By similarity) GPY01_RS09980 ENOG4105CFP Peptidase U32 GPY01_RS09985 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding GPY01_RS10025 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GPY01_RS10030 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase GPY01_RS10035 ENOG4105C34 Pseudouridine synthase GPY01_RS10040 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane GPY01_RS10045 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA GPY01_RS10055 ENOG4107XW0 Spermidine putrescine ABC transporter periplasmic spermidine putrescine-binding protein GPY01_RS10060 ENOG4108K0B C-di-gmp phosphodiesterase GPY01_RS10065 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) GPY01_RS10070 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) GPY01_RS10075 ENOG4107SC1 transglycosylase GPY01_RS10080 ENOG4105C5H ABC transporter GPY01_RS10095 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) GPY01_RS10100 ENOG4108HRK Histidine kinase GPY01_RS10105 ENOG4108NEV two component transcriptional regulator, LytTR family GPY01_RS10110 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) GPY01_RS10115 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) GPY01_RS10120 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate GPY01_RS10135 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) GPY01_RS10140 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase GPY01_RS10145 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) GPY01_RS10150 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) GPY01_RS10155 ENOG4105DTN riboflavin biosynthesis protein ribF GPY01_RS10160 ENOG4105CJR Integral membrane protein (MviN GPY01_RS10165 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) GPY01_RS10170 ENOG41080HT Transcriptional regulator, arsr family GPY01_RS10175 ENOG41063Z6 transcriptional regulator, lysR family GPY01_RS10185 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) GPY01_RS10190 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) GPY01_RS10195 ENOG4105HF0 Membrane GPY01_RS10200 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase GPY01_RS10205 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) GPY01_RS10210 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) GPY01_RS10215 ENOG4105CPC Aldo Keto reductase GPY01_RS10230 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GPY01_RS10235 ENOG4105CRK lysyL-tRNA synthetase GPY01_RS10245 ENOG4105CWM branched-chain amino acid transport system II carrier protein GPY01_RS10250 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) GPY01_RS10255 ENOG4105C1J atp-dependent rna helicase GPY01_RS10260 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) GPY01_RS10265 ENOG4105BZU Histidine kinase GPY01_RS10280 ENOG4108YYD acetyltransferase GPY01_RS10285 ENOG4105XPQ lipid carrier protein GPY01_RS10290 ENOG4105BZU Histidine kinase GPY01_RS10295 ENOG4105CFP Peptidase U32 GPY01_RS10300 ENOG4106RZ4 Peptidase U32 GPY01_RS10315 ENOG4105RT1 May be involved in cell division (By similarity) GPY01_RS10320 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) GPY01_RS10325 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) GPY01_RS10330 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) GPY01_RS10335 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) GPY01_RS10340 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) GPY01_RS10345 ENOG4105CHV Transcription elongation factor NusA GPY01_RS10350 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) GPY01_RS10370 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) GPY01_RS10375 ENOG4105EEI dihydropteroate synthase GPY01_RS10380 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) GPY01_RS10385 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) GPY01_RS10390 ENOG4105HBR Rna-binding protein GPY01_RS10395 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) GPY01_RS10400 ENOG4105FCK Membrane GPY01_RS10405 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase GPY01_RS10410 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) GPY01_RS10415 ENOG4105DR5 peptidase GPY01_RS10430 ENOG4108YX9 iron--sulfur cluster insertion protein erpA GPY01_RS10435 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase GPY01_RS10445 ENOG4105IPI Membrane GPY01_RS10450 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) GPY01_RS10455 ENOG4105BZU Histidine kinase GPY01_RS10460 ENOG4107QRA Extracellular solute-binding protein, family 5 GPY01_RS10470 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GPY01_RS10475 ENOG4105C3U ABC transporter GPY01_RS10480 ENOG4108JQ7 (ABC) transporter GPY01_RS10490 ENOG4105RD7 BadF BadG BcrA BcrD GPY01_RS10495 ENOG4105E2D ec 3.2.1.52 GPY01_RS10500 ENOG4105E2V Glycosyltransferase 36 GPY01_RS10510 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GPY01_RS10530 ENOG4108YZA Nitrogen regulatory protein pii GPY01_RS10535 ENOG4105XTV UPF0231 protein GPY01_RS10540 ENOG4107QIJ Aconitate hydratase 2 GPY01_RS10545 ENOG4105D78 K07001 NTE family protein GPY01_RS10550 ENOG4105BZ4 penicillin-binding protein GPY01_RS10555 ENOG4105CQ7 ATP-dependent helicase GPY01_RS10565 ENOG4105PW4 Sugar fermentation stimulation protein homolog GPY01_RS10570 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters GPY01_RS10575 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) GPY01_RS10580 ENOG4105DJ0 Poly(A) Polymerase GPY01_RS10585 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase GPY01_RS10590 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) GPY01_RS10595 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) GPY01_RS10600 ENOG4105E3A (ABC) transporter GPY01_RS10605 ENOG4105DA5 (ABC) transporter GPY01_RS10610 ENOG4105CHH sulfate transporter GPY01_RS10615 ENOG41077A9 carbonic anhydrase GPY01_RS10620 ENOG4108UGV hypoxanthine phosphoribosyltransferase GPY01_RS10625 ENOG410630P Transcriptional regulator GPY01_RS10630 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) GPY01_RS10635 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) GPY01_RS10640 ENOG41082RQ UPF0102 protein GPY01_RS10645 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) GPY01_RS10650 ENOG4105W4M Transport-associated protein GPY01_RS10655 ENOG4105KB2 stringent starvation protein b GPY01_RS10660 ENOG4107MKT Stringent starvation protein a GPY01_RS10665 ENOG4105EIX cytochrome c1 GPY01_RS10670 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) GPY01_RS10675 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) GPY01_RS10680 ENOG4108UJD 30S ribosomal protein S9 GPY01_RS10685 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) GPY01_RS10690 ENOG4105D6Z AFG1 family ATPase GPY01_RS10700 ENOG4105C0H protease GPY01_RS10705 ENOG4105C0H protease GPY01_RS10710 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) GPY01_RS10715 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) GPY01_RS10720 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) GPY01_RS10725 ENOG4105K5M 30s ribosomal protein S16 GPY01_RS10730 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY GPY01_RS10735 ENOG4106KVJ cytochrome C assembly protein GPY01_RS10740 ENOG4108JU6 CBS domain protein GPY01_RS10745 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) GPY01_RS10750 ENOG4105D9M gamma-glutamylcysteine synthetase GPY01_RS10760 ENOG4105W39 Membrane GPY01_RS10770 ENOG4105D9Q decarboxylase (Beta subunit) GPY01_RS10775 ENOG4107QSA Oxaloacetate decarboxylase GPY01_RS10825 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) GPY01_RS10830 ENOG4105CFH Aspartokinase GPY01_RS10835 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) GPY01_RS10840 ENOG4105Y3E Modulates RecA activity (By similarity) GPY01_RS10845 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) GPY01_RS10855 ENOG4108IJ6 ABC transporter GPY01_RS10860 ENOG4105ECW sulfate abc transporter GPY01_RS10865 ENOG4108I5D sulfate abc transporter GPY01_RS10870 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein GPY01_RS10875 ENOG4105C6T cysteine synthase GPY01_RS10880 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) GPY01_RS10885 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GPY01_RS10890 ENOG4108K5P (LipO)protein GPY01_RS10895 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) GPY01_RS10900 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) GPY01_RS10905 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) GPY01_RS10910 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) GPY01_RS10915 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) GPY01_RS10925 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) GPY01_RS10930 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase GPY01_RS10935 ENOG4107ZVW dihydroneopterin aldolase GPY01_RS10940 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) GPY01_RS10950 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GPY01_RS10955 ENOG4105VCC 30S ribosomal protein S21 GPY01_RS10960 ENOG4105KTH gatB Yqey GPY01_RS10965 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) GPY01_RS10970 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GPY01_RS10985 ENOG4105CH5 extracellular solute-binding protein, family 7 GPY01_RS11010 ENOG4105D70 Integrase catalytic subunit GPY01_RS11015 ENOG4105F5W AtP-binding protein GPY01_RS11085 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) GPY01_RS11090 ENOG410804X Transcriptional regulator GPY01_RS11095 ENOG4105CA9 Pyruvate kinase GPY01_RS11100 ENOG4105MPN Membrane GPY01_RS11105 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) GPY01_RS11110 ENOG4108ZUB Lysine exporter protein (Lyse ygga) GPY01_RS11115 ENOG4105D64 Mechanosensitive ion channel GPY01_RS11125 ENOG4105D2N Aldolase GPY01_RS11130 ENOG4105BZA Phosphoglycerate kinase GPY01_RS11135 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase GPY01_RS11140 ENOG4105D05 Receptor GPY01_RS11145 ENOG4108R4R Iron-regulated virulence regulatory protein GPY01_RS11150 ENOG4105CV1 Transketolase (EC 2.2.1.1) GPY01_RS11155 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP GPY01_RS11160 ENOG4105GPY SprT protein GPY01_RS11165 ENOG4105RWS endonuclease I GPY01_RS11170 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) GPY01_RS11175 ENOG4105D7Z glutathione synthase GPY01_RS11180 ENOG4108UJU UPF0301 protein GPY01_RS11185 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) GPY01_RS11190 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) GPY01_RS11200 ENOG4105CZX twitching motility protein GPY01_RS11205 ENOG4105CZX twitching motility protein GPY01_RS11210 ENOG4105DFA alanine racemase domain protein GPY01_RS11215 ENOG4105II7 pyrroline-5-carboxylate reductase GPY01_RS11220 ENOG4108VIA integral membrane protein GPY01_RS11225 ENOG4105VZ9 UPF0235 protein GPY01_RS11235 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) GPY01_RS11240 ENOG4105CSA Coproporphyrinogen iii oxidase GPY01_RS11245 ENOG4105CSV Glutaminase GPY01_RS11250 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) GPY01_RS11255 ENOG4105CEN a g-specific adenine glycosylase GPY01_RS11260 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) GPY01_RS11265 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division GPY01_RS11320 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) GPY01_RS11325 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) GPY01_RS11330 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) GPY01_RS11335 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) GPY01_RS11340 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) GPY01_RS11345 ENOG4105NWN ApaG protein GPY01_RS11350 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) GPY01_RS11360 ENOG4107XM3 UPF0442 protein GPY01_RS11365 ENOG4105DWK Membrane GPY01_RS11370 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control GPY01_RS11375 ENOG4105K46 50S ribosomal protein l27 GPY01_RS11380 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) GPY01_RS11385 ENOG4105EAH synthase GPY01_RS11390 ENOG4105D5Q Arginine ornithine antiporter GPY01_RS11395 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) GPY01_RS11400 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) GPY01_RS11415 ENOG41081QV Universal stress protein GPY01_RS11435 ENOG4105CEU Arginine dihydrolase GPY01_RS11440 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) GPY01_RS11445 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) GPY01_RS11450 ENOG4105D1U peptidase U62 modulator of DNA gyrase GPY01_RS11460 ENOG4105QD6 exported protein GPY01_RS11465 ENOG4105C03 ribonuclease GPY01_RS11470 ENOG4108Z03 MAF-like protein GPY01_RS11475 ENOG4105VQ7 Rod shape-determining protein MreD GPY01_RS11480 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) GPY01_RS11485 ENOG4105DFF Rod shape-determining protein mreb GPY01_RS11520 ENOG4105X0D Fimbrial protein GPY01_RS11530 ENOG4105D7Q type ii secretion system GPY01_RS11535 ENOG4107QHF type ii secretion system protein e GPY01_RS11550 ENOG4105E4G Type IV pilus GPY01_RS11570 ENOG41062P1 Diguanylate cyclase phosphodiesterase GPY01_RS11575 ENOG4108UUM single-stranded DNA-binding protein GPY01_RS11580 ENOG41086KC Transcriptional regulator GPY01_RS11585 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase GPY01_RS11590 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) GPY01_RS11600 ENOG4105C5R Aminotransferase GPY01_RS11605 ENOG4105CFH Aspartokinase GPY01_RS11610 ENOG4105C3R Methionine synthase GPY01_RS11615 ENOG4105EEQ Na H antiporter GPY01_RS11625 ENOG4105F5W AtP-binding protein GPY01_RS11630 ENOG4105D70 Integrase catalytic subunit GPY01_RS11700 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) GPY01_RS11705 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) GPY01_RS11710 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) GPY01_RS11730 ENOG4105P4Z Phage shock protein G GPY01_RS11735 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) GPY01_RS11740 ENOG4105MYN Zinc uptake regulation protein GPY01_RS11755 ENOG4107QP8 phosphohexose isomerase GPY01_RS11760 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme GPY01_RS11765 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) GPY01_RS11770 ENOG4105CDU Replicative dna helicase GPY01_RS11780 ENOG4105K9Q Binds to the 23S rRNA (By similarity) GPY01_RS11785 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) GPY01_RS11790 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) GPY01_RS11795 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) GPY01_RS11800 ENOG4108UQY Iron-storage protein GPY01_RS11805 ENOG4105W53 bacterioferritin-associated ferredoxin GPY01_RS11810 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) GPY01_RS11815 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) GPY01_RS11820 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) GPY01_RS11825 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) GPY01_RS11835 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) GPY01_RS11840 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) GPY01_RS11845 ENOG4105WWK YheO domain protein GPY01_RS11850 ENOG4108V1T peptidylprolyl cis-trans isomerase GPY01_RS11860 ENOG41069P5 Protein slyX homolog GPY01_RS11870 ENOG4105EPW hflc protein GPY01_RS11875 ENOG4107QJR hflk protein GPY01_RS11880 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) GPY01_RS11885 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) GPY01_RS11890 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) GPY01_RS11895 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) GPY01_RS11900 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase GPY01_RS11905 ENOG4105K8N protein family UPF0079, ATPase GPY01_RS11910 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) GPY01_RS11960 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) GPY01_RS11965 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) GPY01_RS11970 ENOG4105DJ4 phosphatidylserine decarboxylase GPY01_RS11975 ENOG4105C8P )-transporter GPY01_RS11985 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) GPY01_RS11990 ENOG41063SB peptidase GPY01_RS12000 ENOG41062JF Transcriptional regulator GPY01_RS12005 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) GPY01_RS12010 ENOG4105E09 nadh pyrophosphatase GPY01_RS12015 ENOG4108ZVW Anti-RNA polymerase sigma 70 factor GPY01_RS12020 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GPY01_RS12025 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GPY01_RS12030 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) GPY01_RS12035 ENOG4108VZM 50s ribosomal protein L10 GPY01_RS12040 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) GPY01_RS12045 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) GPY01_RS12050 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) GPY01_RS12055 ENOG4105PM1 preprotein translocase subunit SecE GPY01_RS12060 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) GPY01_RS12085 ENOG4105CS9 pantothenic acid kinase GPY01_RS12090 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase GPY01_RS12095 ENOG4105D4A Cell wall formation (By similarity) GPY01_RS12105 ENOG4105JIM Phosphatidylserine synthase GPY01_RS12140 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) GPY01_RS12145 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin GPY01_RS12150 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) GPY01_RS12155 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) GPY01_RS12190 ENOG4108YGG dna repair protein GPY01_RS12205 ENOG4107SCJ type I restriction enzyme EcoKI subunit R GPY01_RS12210 ENOG4105CVR type I restriction-modification system GPY01_RS12245 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) GPY01_RS12250 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GPY01_RS12255 ENOG4105CRP Part of the ABC transporter FtsEX involved in GPY01_RS12260 ENOG4105CAK Cell division ATP-binding protein ftsE GPY01_RS12265 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) GPY01_RS12270 ENOG4106H78 methyltransferase GPY01_RS12300 ENOG4108RMU ferritin dps family protein GPY01_RS12305 ENOG4105D58 Diguanylate phosphodiesterase GPY01_RS12310 ENOG410829K Lysine exporter protein (Lyse ygga) GPY01_RS12315 ENOG4108EUD Lysophospholipase GPY01_RS12320 ENOG4105DQF Hydrolase GPY01_RS12335 ENOG4105BZU Histidine kinase GPY01_RS12340 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant GPY01_RS12345 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GPY01_RS12350 ENOG4105CT0 Protein of unknown function, DUF484 GPY01_RS12355 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) GPY01_RS12360 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) GPY01_RS12370 ENOG4105XQ6 frataxin-like protein GPY01_RS12375 ENOG4107T0K Adenylate cyclase GPY01_RS12385 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) GPY01_RS12390 ENOG41076E6 Uroporphyrinogen-III Synthase GPY01_RS12395 ENOG4105ECF c-methyltransferase GPY01_RS12400 ENOG410601J HemY protein GPY01_RS12405 ENOG4105D4P Coproporphyrinogen iii oxidase GPY01_RS12410 ENOG4105XCT Protein of unknown function (DUF2489) GPY01_RS12415 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) GPY01_RS12425 ENOG4106RE7 Cytochrome GPY01_RS12430 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) GPY01_RS12435 ENOG4105C2M dna polymerase I GPY01_RS12450 ENOG4105D52 delta-aminolevulinic acid dehydratase GPY01_RS12455 ENOG4105F8V Hydrolase, tatD family GPY01_RS12460 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) GPY01_RS12470 ENOG4107SDU Methyl-accepting chemotaxis GPY01_RS12475 ENOG4105X6C Flagellar basal body-associated protein FliL GPY01_RS12485 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) GPY01_RS12490 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) GPY01_RS12495 ENOG4105E55 glycerol-3-phosphate acyltransferase GPY01_RS12500 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) GPY01_RS12510 ENOG4107R73 Mate efflux family protein GPY01_RS12515 ENOG4105CA0 peroxidase GPY01_RS12520 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) GPY01_RS12525 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) GPY01_RS12530 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) GPY01_RS12535 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) GPY01_RS12540 ENOG4105JC1 sterol-binding domain protein GPY01_RS12545 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GPY01_RS12550 ENOG4105CGY Dna recombination protein GPY01_RS12560 ENOG4105CBX hi0933 family GPY01_RS12565 ENOG4108V6B universal stress protein B GPY01_RS12570 ENOG41090A1 ferritin GPY01_RS12580 ENOG4108M6U Universal stress protein A GPY01_RS12585 ENOG4105EMK carboxylate amino acid amine transporter GPY01_RS12595 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) GPY01_RS12600 ENOG4105BZU Histidine kinase GPY01_RS12605 ENOG4108VVK transcriptional Regulator, AsnC GPY01_RS12615 ENOG4105CNH Multidrug resistance protein MdtL GPY01_RS12625 ENOG4105DC7 peptidase M24 GPY01_RS12625 ENOG4105DC7 peptidase M24 GPY01_RS12635 ENOG4105D41 biosynthesis protein thiH GPY01_RS12640 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) GPY01_RS12645 ENOG4105WHD thiamine biosynthesis protein ThiS GPY01_RS12650 ENOG4105D06 uba thif-type nad fad binding protein GPY01_RS12660 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) GPY01_RS12665 ENOG4105WMR Protein CrcB homolog GPY01_RS12705 ENOG4108Z0R Transferase GPY01_RS12715 ENOG4105E2X shikimate dehydrogenase GPY01_RS12720 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) GPY01_RS12725 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GPY01_RS12730 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) GPY01_RS12735 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit GPY01_RS12740 ENOG4108WI1 Dna topoisomerase GPY01_RS12745 ENOG4108RPN Protein smg homolog GPY01_RS12750 ENOG4105C79 DNA protecting protein DprA GPY01_RS12755 ENOG4108WZM domain protein GPY01_RS12760 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GPY01_RS12765 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) GPY01_RS12770 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B GPY01_RS12775 ENOG4105C1A potassium transporter peripheral membrane GPY01_RS12780 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) GPY01_RS12790 ENOG4108UT2 hemolysin iii GPY01_RS12795 ENOG4108N23 SpoOM-related protein GPY01_RS12805 ENOG4105PC1 Conserved Protein GPY01_RS12815 ENOG4105E27 serine threonine protein kinase GPY01_RS12820 ENOG4108Z33 Thiol disulfide Interchange Protein GPY01_RS12825 ENOG4106HNH Acyl-transferase GPY01_RS12830 ENOG4105C0P Mg chelatase subunit ChlI GPY01_RS12845 ENOG4105CM2 brancheD-chain amino acid aminotransferase GPY01_RS12850 ENOG4105C01 Dihydroxy-acid dehydratase GPY01_RS12855 ENOG4105C7B Threonine dehydratase GPY01_RS12860 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family GPY01_RS12870 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) GPY01_RS12875 ENOG4108RS6 transposase GPY01_RS12890 ENOG4107QIB glycyl-tRNA synthetase, alpha subunit GPY01_RS12895 ENOG4105C38 Glycyl-tRNA synthetase beta subunit GPY01_RS12900 ENOG4105JKW Valine--pyruvate aminotransferase GPY01_RS12905 ENOG4108ZNX Heat shock protein GPY01_RS12920 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GPY01_RS12925 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) GPY01_RS12930 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) GPY01_RS12935 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) GPY01_RS12940 ENOG4105EAB amino acid AbC transporter GPY01_RS12945 ENOG4105E5Q amino acid AbC transporter GPY01_RS12960 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) GPY01_RS12965 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) GPY01_RS12970 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins GPY01_RS12975 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) GPY01_RS12980 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GPY01_RS13055 ENOG4107QKA exodeoxyribonuclease V beta GPY01_RS13120 ENOG4105DND Transcriptional regulator GPY01_RS13175 ENOG4105QTB Flavodoxin GPY01_RS13185 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) GPY01_RS13190 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) GPY01_RS13195 ENOG4107QJE Chromosome Partitioning Protein GPY01_RS13200 ENOG4105FA0 parb-like partition protein GPY01_RS13205 ENOG410684E atp synthase GPY01_RS13210 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) GPY01_RS13215 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) GPY01_RS13220 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) GPY01_RS13225 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) GPY01_RS13230 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) GPY01_RS13235 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) GPY01_RS13240 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) GPY01_RS13245 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) GPY01_RS13255 ENOG4105CZQ inner membrane transport protein YdhC GPY01_RS13260 ENOG4105F52 Transcriptional regulator GPY01_RS13265 ENOG4105CHU acetyl-coa acetyltransferase GPY01_RS13270 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GPY01_RS13275 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein GPY01_RS13280 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) GPY01_RS13285 ENOG4108RR8 protoporphyrinogen oxidase GPY01_RS13365 ENOG4105EMY transcriptional regulator GPY01_RS13370 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase GPY01_RS13375 ENOG4105W0Z cytoplasmic protein GPY01_RS13380 ENOG4105BZS acriflavin resistance protein GPY01_RS13385 ENOG410624X efflux transporter, rnd family, mfp subunit GPY01_RS13390 ENOG4105Y7M Transcriptional regulator, TetR family GPY01_RS13395 ENOG4105C4R Atp-dependent dna helicase GPY01_RS13400 ENOG4105MPD Cytochrome GPY01_RS13445 ENOG4105DEF Extracellular solute-binding protein, family 5 GPY01_RS13450 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GPY01_RS13455 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GPY01_RS13465 ENOG4105DC8 reductase GPY01_RS13470 ENOG4105D6S protein involved in catabolism of external DNA GPY01_RS13475 ENOG4105DGW oligopeptidase A GPY01_RS13480 ENOG4105C4R Atp-dependent dna helicase GPY01_RS13490 ENOG4108DMH HTH_ARAC GPY01_RS13495 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) GPY01_RS13500 ENOG4105FR1 rard protein GPY01_RS13505 ENOG4105C9U ATP-dependent DNA helicase RecQ GPY01_RS13520 ENOG4105BZ1 (ABC) transporter GPY01_RS13525 ENOG4105E0K tonB-dependent siderophore receptor GPY01_RS13530 ENOG4105E0A ABC, transporter GPY01_RS13535 ENOG4105J76 Periplasmic binding protein GPY01_RS13540 ENOG4105S6R Iron-hydroxamate transporter permease subunit GPY01_RS13545 ENOG4108PSC Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity) GPY01_RS13555 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate GPY01_RS13565 ENOG4105VNT transposase (IS4 family) protein GPY01_RS13575 ENOG4105DSJ YicC domain protein GPY01_RS13580 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) GPY01_RS13585 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) GPY01_RS13590 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase GPY01_RS13595 ENOG4105D1S lipid A biosynthesis GPY01_RS13600 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) GPY01_RS13610 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase GPY01_RS13615 ENOG4105C8Q Methyl-accepting chemotaxis GPY01_RS13625 ENOG4105KDC 50s ribosomal protein l28 GPY01_RS13630 ENOG4105W0E 50S ribosomal protein L33 GPY01_RS13640 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) GPY01_RS13645 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) GPY01_RS13650 ENOG4105M5K heptosyltransferase GPY01_RS13655 ENOG4106WTF Glycosyl transferase, family 2 GPY01_RS13660 ENOG4105DKP glycosyl transferase, family 9 GPY01_RS13665 ENOG4108W7E Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity) GPY01_RS13670 ENOG4105EXC Acyl-transferase GPY01_RS13700 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase GPY01_RS13705 ENOG4108ST3 glycosyltransferase GPY01_RS13710 ENOG4105XA0 heptosyltransferase ii GPY01_RS13730 ENOG4107T94 Endo-14-beta-xylanase GPY01_RS13735 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) GPY01_RS13740 ENOG4108KPN Confers a modal distribution of chain length on the O- antigen component of lipopolysaccharide (LPS). Gives rise to a reduced number of short chain molecules and increases in numbers of longer molecules, with a modal value of 13 (in strain O111 M92) and of 17 (in strain K12) GPY01_RS13745 ENOG4105C1B dTDP-glucose 4-6-dehydratase GPY01_RS13750 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) GPY01_RS13770 ENOG4105BZ1 (ABC) transporter GPY01_RS13790 ENOG4105C5E polysaccharide biosynthesis protein GPY01_RS13800 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase GPY01_RS13810 ENOG4105D3Q Sugar transferase GPY01_RS13820 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase GPY01_RS13840 ENOG4105E3R (LipO)protein GPY01_RS13850 ENOG4108MDC (LipO)protein GPY01_RS13860 ENOG4105DAY polysaccharide export protein GPY01_RS13870 ENOG4105D75 Capsular exopolysaccharide family GPY01_RS13890 ENOG4107QRS glycosyltransferase group 2 family protein GPY01_RS13900 ENOG41068D6 Glycosyltransferase GPY01_RS13905 ENOG4107QPH glycogen) synthase GPY01_RS13925 ENOG4105CY0 Metallo-Beta-Lactamase GPY01_RS13940 ENOG4105CUY Mechanosensitive ion channel GPY01_RS13945 ENOG4108RG0 uracil-dna glycosylase GPY01_RS13950 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase GPY01_RS13955 ENOG4105R2J Conserved Protein GPY01_RS13965 ENOG4105K70 DNA-binding protein GPY01_RS13975 ENOG4105C12 Phosphoribosylglycinamide synthetase GPY01_RS13980 ENOG4105DC1 bifunctional purine biosynthesis protein purh GPY01_RS13990 ENOG4105W1Y Transcriptional regulator GPY01_RS13995 ENOG4108M3R transcriptional activator CadC GPY01_RS14000 ENOG4105D5Q Arginine ornithine antiporter GPY01_RS14005 ENOG4105CXN decarboxylase GPY01_RS14010 ENOG4105C8Q Methyl-accepting chemotaxis GPY01_RS14025 ENOG4105E0K tonB-dependent siderophore receptor GPY01_RS14030 ENOG4108UHU Aldolase GPY01_RS14035 ENOG4105C6Z Gluconate GPY01_RS14040 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family GPY01_RS14045 ENOG4105C01 Dihydroxy-acid dehydratase GPY01_RS14050 ENOG4105EWV Sodium calcium exchanger membrane region GPY01_RS14060 ENOG4105DIQ Transcriptional regulator GPY01_RS14065 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) GPY01_RS14070 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) GPY01_RS14075 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) GPY01_RS14080 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase GPY01_RS14085 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein GPY01_RS14090 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) GPY01_RS14095 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GPY01_RS14115 ENOG4105D8G Major Facilitator superfamily GPY01_RS14120 ENOG4105BZU Histidine kinase GPY01_RS14125 ENOG4105C9X ppx gppa phosphatase GPY01_RS14130 ENOG4105C1J atp-dependent rna helicase GPY01_RS14135 ENOG4105K63 Thioredoxin GPY01_RS14140 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) GPY01_RS14150 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) GPY01_RS14160 ENOG4107QK7 reductase GPY01_RS14230 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) GPY01_RS14235 ENOG4105BZU Histidine kinase GPY01_RS14240 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GPY01_RS14245 ENOG4105CUX Signal transduction histidine kinase GPY01_RS14255 ENOG4105C5F glutamine synthetase GPY01_RS14270 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) GPY01_RS14280 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) GPY01_RS14285 ENOG4105SUU thioesterase domain GPY01_RS14295 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase GPY01_RS14300 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) GPY01_RS14305 ENOG4105VEJ Heat shock protein GPY01_RS14310 ENOG4108XKW General secretion pathway protein C GPY01_RS14320 ENOG4107QHF type ii secretion system protein e GPY01_RS14325 ENOG4105D7Q type ii secretion system GPY01_RS14330 ENOG4108VAU general secretion pathway protein G GPY01_RS14335 ENOG4105VWV general secretion pathway protein h GPY01_RS14340 ENOG4105X5Z General secretion pathway protein I GPY01_RS14345 ENOG4108WWZ General secretion pathway protein J GPY01_RS14350 ENOG4108RTD type II secretion system protein K GPY01_RS14355 ENOG4108BY5 Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity) GPY01_RS14360 ENOG4105U1E general secretion pathway protein M GPY01_RS14365 ENOG4105PIC general secretion pathway protein N GPY01_RS14370 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase GPY01_RS14375 ENOG4107RK2 ADP-ribose diphosphatase NudE GPY01_RS14380 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) GPY01_RS14385 ENOG4105MJ2 Competence protein GPY01_RS14390 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) GPY01_RS14400 ENOG4105BZM domain protein GPY01_RS14405 ENOG4108RRZ Transcription elongation factor GreB GPY01_RS14430 ENOG4105C2J ABC transporter GPY01_RS14435 ENOG4105CNN ABC, transporter GPY01_RS14440 ENOG4105D17 glycoside hydrolase, family 3 domain protein GPY01_RS14450 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GPY01_RS14455 ENOG4105E0F Histidine kinase GPY01_RS14460 ENOG4105C2W permease GPY01_RS14465 ENOG4105CB5 ATP-dependent DNA helicase recG GPY01_RS14470 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) GPY01_RS14475 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) GPY01_RS14480 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) GPY01_RS14485 ENOG4105EX9 Membrane GPY01_RS14490 ENOG4107QN1 sodium solute GPY01_RS14500 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) GPY01_RS14510 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) GPY01_RS14520 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter GPY01_RS14525 ENOG4108IJ0 Aspartate ammonia-lyase GPY01_RS14530 ENOG4105BZU Histidine kinase GPY01_RS14535 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 GPY01_RS14540 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) GPY01_RS14550 ENOG4105E0F Histidine kinase GPY01_RS14555 ENOG4105E3W Two component transcriptional regulator (Winged helix family GPY01_RS14565 ENOG41076HS cation diffusion facilitator family transporter GPY01_RS14570 ENOG4105CTQ phosphohexokinase GPY01_RS14575 ENOG4105CBT Fructose-1,6-bisphosphatase GPY01_RS14580 ENOG41065UX Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) GPY01_RS14585 ENOG4105SYT Methylenetetrahydrofolate reductase GPY01_RS14590 ENOG4105CFH Aspartokinase GPY01_RS14595 ENOG4105C28 cystathionine GPY01_RS14600 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) GPY01_RS14605 ENOG4105C6K Malic enzyme GPY01_RS14610 ENOG4105VFB Binds the 23S rRNA (By similarity) GPY01_RS14615 ENOG4105C25 Primosomal protein n' GPY01_RS14620 ENOG4105ETE Transcriptional regulator (LacI family GPY01_RS14625 ENOG41063M6 Cell Division Protein GPY01_RS14630 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) GPY01_RS14635 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) GPY01_RS14640 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase GPY01_RS14645 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) GPY01_RS14655 ENOG4105CP7 Triose-phosphate isomerase GPY01_RS14680 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) GPY01_RS14685 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) GPY01_RS14695 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein GPY01_RS14700 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) GPY01_RS14705 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) GPY01_RS14710 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) GPY01_RS14715 ENOG4105E33 succinate dehydrogenase GPY01_RS14725 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) GPY01_RS14730 ENOG4107YZP Rhodanese domain protein GPY01_RS14735 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) GPY01_RS14740 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase GPY01_RS14745 ENOG4105D7W serine acetyltransferase GPY01_RS14760 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) GPY01_RS14765 ENOG4105CWC Acetylornithine deacetylase GPY01_RS14770 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase GPY01_RS14775 ENOG4105CAS nag kinase GPY01_RS14780 ENOG4105CDH Citrulline--aspartate ligase GPY01_RS14785 ENOG4105CH7 arginosuccinase GPY01_RS14795 ENOG4107QN2 dihydrolipoyl dehydrogenase GPY01_RS14800 ENOG4105EHV domain protein GPY01_RS14810 ENOG4108JQC penicillin-binding protein 1A GPY01_RS14835 ENOG4105E4G Type IV pilus GPY01_RS14840 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) GPY01_RS14845 ENOG4105D49 3-dehydroquinate synthase GPY01_RS14855 ENOG4105DFE Dna adenine methylase GPY01_RS14860 ENOG4105DJV ribulose-phosphate 3-epimerase GPY01_RS14865 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) GPY01_RS14870 ENOG4105C31 Tryptophanyl-tRNA synthetase GPY01_RS14885 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) GPY01_RS14895 ENOG4105DFP Integrase GPY01_RS14920 ENOG4105KT5 UmuD protein GPY01_RS14975 ENOG4105ESI atpase involved in dna repair GPY01_RS15005 ENOG4105MRD Phage derived protein Gp49-like (DUF891) GPY01_RS15065 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GPY01_RS15070 ENOG4105T95 Thiol disulfide interChange protein GPY01_RS15110 ENOG4105C79 DNA protecting protein DprA GPY01_RS15115 ENOG4105C9U ATP-dependent DNA helicase RecQ GPY01_RS15145 ENOG4108UUM single-stranded DNA-binding protein GPY01_RS15160 ENOG4105GMT ATPase associated with various cellular activities aaa_5 GPY01_RS15185 ENOG4108YGG dna repair protein GPY01_RS15265 ENOG4105DDQ anthranilate synthase GPY01_RS15270 ENOG4105C8Y Acetylornithine aminotransferase GPY01_RS15280 ENOG4105C26 Dehydrogenase GPY01_RS15290 ENOG4107RYR Transcriptional regulator, Crp Fnr family GPY01_RS15295 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) GPY01_RS15305 ENOG4105DNZ Alpha Beta Hydrolase GPY01_RS15315 ENOG4105C5H ABC transporter GPY01_RS15320 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein GPY01_RS15335 ENOG4108YZY peptidylprolyl cis-trans isomerase GPY01_RS15340 ENOG4105D44 asparaginase GPY01_RS15345 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis GPY01_RS15350 ENOG4108UV7 flagellar protein motX GPY01_RS15355 ENOG4105E68 Sulfatase GPY01_RS15360 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) GPY01_RS15365 ENOG4105C2N RNA methyltransferase TrmH family group 3 GPY01_RS15375 ENOG4108RS6 transposase GPY01_RS15380 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) GPY01_RS15385 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) GPY01_RS15390 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) GPY01_RS15395 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) GPY01_RS15400 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity GPY01_RS15405 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) GPY01_RS15410 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) GPY01_RS15415 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) GPY01_RS15420 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) GPY01_RS15425 ENOG41083MP 50s ribosomal protein l29 GPY01_RS15430 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal GPY01_RS15435 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) GPY01_RS15440 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) GPY01_RS15445 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits GPY01_RS15450 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) GPY01_RS15455 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) GPY01_RS15460 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) GPY01_RS15465 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) GPY01_RS15470 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) GPY01_RS15475 ENOG4105VPB 50S ribosomal protein L30 GPY01_RS15480 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) GPY01_RS15485 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) GPY01_RS15495 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits GPY01_RS15500 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) GPY01_RS15505 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) GPY01_RS15510 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GPY01_RS15515 ENOG4108ZT0 50S ribosomal protein l17 GPY01_RS15525 ENOG4108V1T peptidylprolyl cis-trans isomerase GPY01_RS15530 ENOG4108UBT opacity-associated protein GPY01_RS15535 ENOG4108SXK Transporter Drug Metabolite Exporter family GPY01_RS15540 ENOG4107YB6 acetyltransferase, (GNAT) family GPY01_RS15545 ENOG4105C1J atp-dependent rna helicase GPY01_RS15555 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic GPY01_RS15560 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GPY01_RS15565 ENOG4105C11 sulfate adenylyltransferase), subunit 2 GPY01_RS15570 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) GPY01_RS15575 ENOG4107UCJ Catalyzes the synthesis of activated sulfate (By similarity) GPY01_RS15595 ENOG4107R39 (ABC) transporter GPY01_RS15610 ENOG4108UUE Transcriptional regulator GPY01_RS15615 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) GPY01_RS15620 ENOG4105CFU surface antigen GPY01_RS15625 ENOG4105MA0 exported protein GPY01_RS15630 ENOG41066HZ AIG2-like family GPY01_RS15635 ENOG4105F0N pyrophosphate phospho-hydrolase GPY01_RS15640 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 GPY01_RS15645 ENOG4105DFU Cell wall formation (By similarity) GPY01_RS15650 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase GPY01_RS15655 ENOG4105DP9 ABC transporter GPY01_RS15660 ENOG4106SMU thiamine transporter membrane protein GPY01_RS15665 ENOG4107T0D ABC, transporter GPY01_RS15670 ENOG4105N42 UPF0307 protein GPY01_RS15675 ENOG4105CMS peptidase U62, modulator of DNA gyrase GPY01_RS15680 ENOG4105CJW magnesium transporter GPY01_RS15685 ENOG41080Z8 PHOSPHOCARRIER protein GPY01_RS15695 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN GPY01_RS15700 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA GPY01_RS15705 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GPY01_RS15710 ENOG4108IUZ ABC transporter GPY01_RS15715 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA GPY01_RS15725 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase GPY01_RS15730 ENOG4105C2X Arabinose 5-phosphate isomerase GPY01_RS15740 ENOG4105DHJ ABC, transporter GPY01_RS15745 ENOG4105CY3 ABC transporter, permease GPY01_RS15750 ENOG4107PE3 Mammalian cell entry related domain protein GPY01_RS15755 ENOG4105E3I toluene tolerance GPY01_RS15765 ENOG4105VFK BolA family GPY01_RS15770 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) GPY01_RS15775 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase GPY01_RS15780 ENOG4105KME endoribonuclease L-psp GPY01_RS15785 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) GPY01_RS15790 ENOG4105CXT aspartate transcarbamylase GPY01_RS15795 ENOG4105DBV ornithine carbamoyltransferase GPY01_RS15800 ENOG4108IAB Phoh family GPY01_RS15805 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) GPY01_RS15810 ENOG4105D3G Pseudouridine synthase GPY01_RS15815 ENOG4105C5I Dehydrogenase GPY01_RS15820 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) GPY01_RS15825 ENOG4105MYG DNA polymerase iii, chi subunit GPY01_RS15830 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) GPY01_RS15835 ENOG4108M8S permease YjgP YjgQ family protein GPY01_RS15840 ENOG4108K5H permease YjgP YjgQ family protein GPY01_RS15855 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase GPY01_RS15900 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GPY01_RS15905 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GPY01_RS15910 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) GPY01_RS15915 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) GPY01_RS15930 ENOG41064T2 transcriptional regulator, lysR family GPY01_RS15935 ENOG4108IQE Amp-dependent synthetase and ligase GPY01_RS15940 ENOG4105C7K acetolactate synthase GPY01_RS15945 ENOG4108ZP8 Acetolactate synthase small subunit GPY01_RS15950 ENOG4108JQ1 Dehydrogenase GPY01_RS15955 ENOG4105E66 phosphoriboisomerase A GPY01_RS15960 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase GPY01_RS15970 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) GPY01_RS15980 ENOG4105D0A hydroxylase GPY01_RS15985 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family GPY01_RS16000 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) GPY01_RS16005 ENOG4105Y75 tpr repeat protein GPY01_RS16015 ENOG4108IYU L-aspartate oxidase GPY01_RS16020 ENOG4105EMN RNA polymerase sigma factor GPY01_RS16030 ENOG4105VQK sigma E regulatory protein, MucB RseB GPY01_RS16035 ENOG4105WMJ Positive regulator of sigma E, RseC MucC GPY01_RS16040 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) GPY01_RS16045 ENOG4105C3F Signal peptidase i GPY01_RS16050 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) GPY01_RS16055 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) GPY01_RS16060 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) GPY01_RS16065 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) GPY01_RS16070 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) GPY01_RS16095 ENOG4105BZU Histidine kinase GPY01_RS16100 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) GPY01_RS16105 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) GPY01_RS16110 ENOG4105DXN mazG family GPY01_RS16115 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) GPY01_RS16120 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) GPY01_RS16125 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate GPY01_RS16140 ENOG4106MWK domain protein GPY01_RS16145 ENOG4105CJ3 phosphate transporter GPY01_RS16150 ENOG4107IX6 phosphate transport regulator GPY01_RS16155 ENOG4105I7R Adenylate cyclase GPY01_RS16160 ENOG4105C8Q Methyl-accepting chemotaxis GPY01_RS16165 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) GPY01_RS16175 ENOG4105DFG type I secretion outer membrane protein GPY01_RS16180 ENOG41087AY ADP-Ribose pyrophosphatase GPY01_RS16185 ENOG4108SX3 cytoplasmic protein GPY01_RS16190 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) GPY01_RS16195 ENOG4105IPS esterase GPY01_RS16200 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GPY01_RS16205 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GPY01_RS16210 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) GPY01_RS16215 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) GPY01_RS16220 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) GPY01_RS16225 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) GPY01_RS16230 ENOG4105D7Q type ii secretion system GPY01_RS16235 ENOG4107QHF type ii secretion system protein e GPY01_RS16245 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase GPY01_RS16255 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) GPY01_RS16260 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GPY01_RS16265 ENOG4105T95 Thiol disulfide interChange protein GPY01_RS16270 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) GPY01_RS16275 ENOG4105CGH 5'-nucleotidase GPY01_RS16280 ENOG41073TP transcriptional regulator GPY01_RS16285 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) GPY01_RS16290 ENOG4107QSN dihydrolipoamide acetyltransferase GPY01_RS16295 ENOG4107QN2 dihydrolipoyl dehydrogenase GPY01_RS16305 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) GPY01_RS16310 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) GPY01_RS16315 ENOG4105CJN penicillin-binding protein GPY01_RS16320 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) GPY01_RS16325 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) GPY01_RS16330 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) GPY01_RS16335 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) GPY01_RS16345 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) GPY01_RS16350 ENOG4105DFU Cell wall formation (By similarity) GPY01_RS16355 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) GPY01_RS16360 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) GPY01_RS16365 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) GPY01_RS16370 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) GPY01_RS16380 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving GPY01_RS16385 ENOG4105M6F mutator MutT protein GPY01_RS16390 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) GPY01_RS16400 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain GPY01_RS16405 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain GPY01_RS16425 ENOG4105EJ9 Membrane GPY01_RS16430 ENOG4105VP0 transcriptional regulator, lysR family GPY01_RS16435 ENOG4105EN6 Membrane GPY01_RS16440 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) GPY01_RS16450 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) GPY01_RS16460 ENOG4105BZ8 glutamate synthase GPY01_RS16465 ENOG4105CBC glutamate synthase GPY01_RS16480 ENOG4105N5T Radical SAM Protein GPY01_RS16490 ENOG4105BZU Histidine kinase GPY01_RS16495 ENOG41065U4 response regulator GPY01_RS16505 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) GPY01_RS16525 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) GPY01_RS16530 ENOG4105D98 threonine synthase GPY01_RS16535 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) GPY01_RS16540 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) GPY01_RS16545 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) GPY01_RS16560 ENOG4105BZG amino acid carrier protein GPY01_RS16575 ENOG4105EYA deoxyribonuclease GPY01_RS16580 ENOG4105D9N nucleoside GPY01_RS16590 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) GPY01_RS16595 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) GPY01_RS16600 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) GPY01_RS16605 ENOG4105D3A purine nucleoside phosphorylase DeoD-type GPY01_RS16615 ENOG4105EAC phosphoserine phosphatase GPY01_RS16625 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) GPY01_RS16630 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) GPY01_RS16635 ENOG4108IQE Amp-dependent synthetase and ligase GPY01_RS16640 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase GPY01_RS16650 ENOG4105CNT hydrolase family 2 GPY01_RS16655 ENOG41060NJ transcriptional regulator GPY01_RS16660 ENOG4108Y51 tRNA-binding protein GPY01_RS16675 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) GPY01_RS16680 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) GPY01_RS16690 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) GPY01_RS16695 ENOG4105X2V dna damage-inducible protein GPY01_RS16710 ENOG4105DSY exodeoxyribonuclease V, gamma GPY01_RS16715 ENOG4107QKA exodeoxyribonuclease V beta GPY01_RS16720 ENOG4107QYX exodeoxyribonuclease v alpha GPY01_RS16730 ENOG4107QZM n-acetylglutamate synthase GPY01_RS16740 ENOG4105CA3 membrane-bound lytic murein transglycosylase GPY01_RS16745 ENOG4105CUZ uba thif-type nad fad binding protein GPY01_RS16750 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) GPY01_RS16755 ENOG4105C9B Cysteine desulfurase GPY01_RS16760 ENOG4107S0N DJ-1 family GPY01_RS16765 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) GPY01_RS16780 ENOG4105K6V RNA polymerase GPY01_RS16790 ENOG4105EYM Major Facilitator superfamily GPY01_RS16800 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) GPY01_RS16810 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) GPY01_RS16815 ENOG4105M85 Bola protein GPY01_RS16820 ENOG4105DWQ NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) GPY01_RS16825 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) GPY01_RS16830 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) GPY01_RS16835 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) GPY01_RS16840 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) GPY01_RS16845 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) GPY01_RS16850 ENOG4105CJ2 (LipO)protein GPY01_RS16860 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) GPY01_RS16870 ENOG4105BZU Histidine kinase GPY01_RS16875 ENOG4105C8J )-transporter GPY01_RS16880 ENOG4105VNT transposase (IS4 family) protein GPY01_RS16890 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) GPY01_RS16895 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) GPY01_RS16900 ENOG4105CIN aminoacyl-histidine dipeptidase GPY01_RS16905 ENOG4105C7N Xanthine uracil vitamin C permease GPY01_RS16910 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) GPY01_RS16920 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) GPY01_RS16925 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) GPY01_RS16930 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) GPY01_RS16935 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) GPY01_RS16940 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) GPY01_RS16955 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) GPY01_RS16960 ENOG4107YIM Involved in the transcription termination process (By similarity) GPY01_RS16965 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) GPY01_RS16970 ENOG4108ZAI phosphatidylglycerophosphatase a GPY01_RS16975 ENOG4108T8E UPF0325 protein GPY01_RS16980 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) GPY01_RS16985 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) GPY01_RS16990 ENOG4105CE9 30S ribosomal protein S2 GPY01_RS16995 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) GPY01_RS17000 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) GPY01_RS17005 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) GPY01_RS17010 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) GPY01_RS17015 ENOG4105KNE Phosphatidate cytidylyltransferase GPY01_RS17020 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) GPY01_RS17025 ENOG4105DZP Membrane-associated zinc metalloprotease GPY01_RS17035 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) GPY01_RS17040 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) GPY01_RS17045 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) GPY01_RS17050 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) GPY01_RS17055 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) GPY01_RS17060 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GPY01_RS17065 ENOG4105C0B DNA polymerase III (alpha subunit) GPY01_RS17070 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) GPY01_RS17075 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) GPY01_RS17080 ENOG4105N7H Cytochrome GPY01_RS17085 ENOG4105PY6 Phenolic acid decarboxylase GPY01_RS17090 ENOG4108YZA Nitrogen regulatory protein pii GPY01_RS17100 ENOG4105E9H Lytic Murein transglycosylase GPY01_RS17105 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) GPY01_RS17110 ENOG4105D1A Methyltransferase GPY01_RS17115 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GPY01_RS17120 ENOG4108JDX DNA polymerase iii, epsilon subunit GPY01_RS17130 ENOG4107QPN acyl-Coa dehydrogenase GPY01_RS17135 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) GPY01_RS17140 ENOG4105E7A Glutamine amidotransferase GPY01_RS17145 ENOG4108V3E phosphoribosylglycinamide formyltransferase GPY01_RS17150 ENOG4105CXB phosphoribosylaminoimidazole synthetase GPY01_RS17155 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) GPY01_RS17160 ENOG4105BZU Histidine kinase GPY01_RS17165 ENOG4105FE9 pseudouridine synthase GPY01_RS17170 ENOG4108DG9 Smr protein MutS2 GPY01_RS17185 ENOG4105MBR gumn family GPY01_RS17190 ENOG4105E2D ec 3.2.1.52 GPY01_RS17200 ENOG4105C59 p-type ATPase GPY01_RS17205 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) GPY01_RS17210 ENOG4105UYK outer membrane protein a GPY01_RS17220 ENOG4107RBR Receptor GPY01_RS17225 ENOG4105Q26 Siderophore-interacting protein GPY01_RS17230 ENOG4105C0W non-ribosomal peptide synthetase GPY01_RS17265 ENOG4107R88 Chemotaxis protein (CheV) GPY01_RS17270 ENOG4105BZU Histidine kinase GPY01_RS17275 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) GPY01_RS17280 ENOG4108ZC9 flagellar basal-body rod protein flgc GPY01_RS17285 ENOG4105W00 Flagellar hook capping protein GPY01_RS17290 ENOG4105BZE flagellar hook protein, FlgE GPY01_RS17295 ENOG4108KPB Flagellar basal-body rod protein FlgF GPY01_RS17300 ENOG4105CGA flagellar basal-body rod protein FlgG GPY01_RS17305 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) GPY01_RS17310 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) GPY01_RS17315 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj GPY01_RS17335 ENOG4105I03 Flagellin GPY01_RS17340 ENOG4105I03 Flagellin GPY01_RS17425 ENOG4105C3G gtp-binding protein GPY01_RS17430 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) GPY01_RS17435 ENOG4105C5T Phosphoribosyl pyrophosphate synthase GPY01_RS17440 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) GPY01_RS17445 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) GPY01_RS17450 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) GPY01_RS17455 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) GPY01_RS17460 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) GPY01_RS17465 ENOG4108YY7 Invasion gene expression up-regulator SirB GPY01_RS17470 ENOG41063JG Transcriptional regulator GPY01_RS17475 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase GPY01_RS17480 ENOG4105CGH 5'-nucleotidase GPY01_RS17485 ENOG4108Z66 YbaK ebsC protein GPY01_RS17490 ENOG4105C2W permease GPY01_RS17505 ENOG4105CS1 NAD(P)H quinone oxidoreductase GPY01_RS17510 ENOG4105K89 arsenate reductase GPY01_RS17515 ENOG4105ERG peptidase m48, ste24p GPY01_RS17530 ENOG4105VNT transposase (IS4 family) protein GPY01_RS17535 ENOG4105C8Q Methyl-accepting chemotaxis GPY01_RS17540 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GPY01_RS17550 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GPY01_RS17555 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) GPY01_RS17570 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) GPY01_RS17575 ENOG4105KUZ arsenate reductase GPY01_RS17590 ENOG4105QZU Inner membrane protein YfeZ GPY01_RS17595 ENOG4105EZR dyp-type peroxidase family protein GPY01_RS17600 ENOG4105I03 Flagellin GPY01_RS17605 ENOG4105I03 Flagellin GPY01_RS17610 ENOG4105I03 Flagellin GPY01_RS17615 ENOG41063QE flagellar protein FlaG GPY01_RS17620 ENOG4107W9T flagellar hook-associated GPY01_RS17630 ENOG4105MQ3 flagellar protein FliS GPY01_RS17635 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GPY01_RS17640 ENOG4105BZU Histidine kinase GPY01_RS17645 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GPY01_RS17650 ENOG4105VQ0 flagellar hook-basal body complex protein fliE GPY01_RS17655 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) GPY01_RS17660 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) GPY01_RS17665 ENOG4105W2B Flagellar assembly protein GPY01_RS17670 ENOG4108JIR Flagellum-specific ATP synthase GPY01_RS17690 ENOG4105X6C Flagellar basal body-associated protein FliL GPY01_RS17695 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) GPY01_RS17700 ENOG4105DD5 Flagellar motor switch protein GPY01_RS17705 ENOG4105VTB flagellar biosynthesis protein fliO GPY01_RS17710 ENOG4105CN7 Flagellar biosynthetic protein FliP GPY01_RS17715 ENOG4105VS8 Flagellar biosynthetic protein fliq GPY01_RS17720 ENOG4105D19 Role in flagellar biosynthesis (By similarity) GPY01_RS17725 ENOG4105D00 flagellar biosynthetic protein flhB GPY01_RS17735 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) GPY01_RS17740 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase GPY01_RS17745 ENOG4105EN6 Membrane GPY01_RS17750 ENOG4108BPE -transporting atpase GPY01_RS17755 ENOG4105MH2 YfcL protein GPY01_RS17760 ENOG4105Q8W reductase GPY01_RS17765 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) GPY01_RS17770 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GPY01_RS17775 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) GPY01_RS17780 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) GPY01_RS17785 ENOG41090R7 Ferric uptake GPY01_RS17795 ENOG4105CMU LysR family (Transcriptional regulator GPY01_RS17800 ENOG4105VAW lrga family GPY01_RS17805 ENOG41067MG lrgb family GPY01_RS17810 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) GPY01_RS17820 ENOG4105EV9 Alpha Beta Hydrolase GPY01_RS17825 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) GPY01_RS17830 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 GPY01_RS17840 ENOG4107QNR UPF0135 protein GPY01_RS17845 ENOG4105BZN citrate synthase GPY01_RS17850 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit GPY01_RS17855 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein GPY01_RS17860 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) GPY01_RS17865 ENOG4105E33 succinate dehydrogenase GPY01_RS17870 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 GPY01_RS17875 ENOG4105C7S Dehydrogenase GPY01_RS17880 ENOG4105CMV Succinyl-CoA synthetase subunit beta GPY01_RS17885 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha GPY01_RS17890 ENOG4105FAV ABC, transporter GPY01_RS17895 ENOG4105FDK ABC transporter GPY01_RS17900 ENOG4105NXV High-affinity zinc uptake system protein GPY01_RS17905 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) GPY01_RS17910 ENOG4105XFK Ferrous iron transport protein A GPY01_RS17930 ENOG4105C75 arginyL-tRNA synthetase GPY01_RS17940 ENOG4108JQM Insulinase (Peptidase family M16) GPY01_RS17945 ENOG4108BY2 phosphohistidine phosphatase GPY01_RS17950 ENOG4105D7B Flagellar biosynthesis protein flha GPY01_RS17955 ENOG4105FZW flagellar biosynthesis regulator FlhF GPY01_RS17960 ENOG4107R21 site-determining protein GPY01_RS17965 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GPY01_RS17970 ENOG4108VYJ response regulator receiver protein GPY01_RS17975 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) GPY01_RS17980 ENOG4105CBS Chea signal transduction histidine kinase GPY01_RS17985 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) GPY01_RS17990 ENOG4107QJE Chromosome Partitioning Protein GPY01_RS18000 ENOG4108V3W Chemotaxis protein, CheW GPY01_RS18010 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) GPY01_RS18015 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) GPY01_RS18020 ENOG41060IM Heme exporter protein GPY01_RS18025 ENOG41067VX Heme exporter protein GPY01_RS18030 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) GPY01_RS18035 ENOG4105DA4 cytochrome c-type biogenesis protein GPY01_RS18040 ENOG4107QX9 Thiol disulfide interChange protein GPY01_RS18045 ENOG4105KWW Biogenesis protein GPY01_RS18055 ENOG410903C (LipO)protein GPY01_RS18070 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GPY01_RS18075 ENOG4105M2J Glutaredoxin GPY01_RS18080 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) GPY01_RS18085 ENOG4105DGU Histone deacetylase GPY01_RS18100 ENOG4105E68 Sulfatase GPY01_RS18110 ENOG4106V8H Nucleoid-associated protein GPY01_RS18120 ENOG4105DFD Na H antiporter GPY01_RS18125 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) GPY01_RS18130 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein GPY01_RS18135 ENOG4108EKI Dehydrogenase GPY01_RS18140 ENOG4105VNT transposase (IS4 family) protein GPY01_RS18150 ENOG4105CHH sulfate transporter GPY01_RS18155 ENOG4105C03 ribonuclease GPY01_RS18160 ENOG4105EI2 Pseudouridine synthase GPY01_RS18165 ENOG4108UHJ MAF-like protein GPY01_RS18170 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein GPY01_RS18175 ENOG4105VGS 50s ribosomal protein l32 GPY01_RS18180 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) GPY01_RS18185 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GPY01_RS18190 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase GPY01_RS18195 ENOG4105CHR reductase GPY01_RS18200 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) GPY01_RS18205 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GPY01_RS18210 ENOG4105YAZ 4-amino-4-deoxychorismate lyase GPY01_RS18215 ENOG4105HHA aminodeoxychorismate lyase GPY01_RS18220 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) GPY01_RS18225 ENOG4107QRG dna polymerase iii GPY01_RS18230 ENOG4105F8V Hydrolase, tatD family GPY01_RS18235 ENOG4105CI1 PTS System GPY01_RS18245 ENOG4105C8J )-transporter GPY01_RS18260 ENOG4108NRW Phospholipase, patatin family GPY01_RS18265 ENOG4105CA9 Pyruvate kinase GPY01_RS18270 ENOG4105DAG ROK family GPY01_RS18275 ENOG4107R88 Chemotaxis protein (CheV) GPY01_RS18290 ENOG4105DHI Methyltransferase GPY01_RS18300 ENOG4105DSB aldose 1-epimerase GPY01_RS18305 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase GPY01_RS18310 ENOG4105E0X reductase GPY01_RS18320 ENOG4105VUT cytoplasmic protein GPY01_RS18325 ENOG4105HDK L-asparaginase GPY01_RS18330 ENOG4105D07 Signal peptide peptidase, SppA GPY01_RS18335 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GPY01_RS18345 ENOG4108RS6 transposase GPY01_RS18350 ENOG4105CIY formyltetrahydrofolate deformylase GPY01_RS18360 ENOG4105DVT helicase GPY01_RS18365 ENOG41072GX Peptidase M22 Glycoprotease GPY01_RS18380 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) GPY01_RS18385 ENOG4105CEY Amp-dependent synthetase and ligase GPY01_RS18390 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) GPY01_RS18405 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein GPY01_RS18410 ENOG4105DK2 UPF0207 protein GPY01_RS18415 ENOG4105CHM Aminotransferase GPY01_RS18420 ENOG4105E4F Isochorismate synthase GPY01_RS18425 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) GPY01_RS18430 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) GPY01_RS18435 ENOG4108IPT Naphthoate synthase GPY01_RS18440 ENOG4105DNI Converts SHCHC to OSB (By similarity) GPY01_RS18445 ENOG4105CEY Amp-dependent synthetase and ligase GPY01_RS18450 ENOG4105DKK Benzoate GPY01_RS18455 ENOG4108JCI Transcriptional regulator GPY01_RS18460 ENOG4108N3W hemolysin secretion protein GPY01_RS18465 ENOG4107S74 Lysophospholipid transporter LplT GPY01_RS18490 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) GPY01_RS18495 ENOG4107QMS site-determining protein GPY01_RS18500 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) GPY01_RS18505 ENOG4105VNG YcgL domain-containing protein GPY01_RS18510 ENOG4105CVE Lytic murein transglycosylase GPY01_RS18515 ENOG4105JQN Transcriptional regulator GPY01_RS18520 ENOG4105D9N nucleoside GPY01_RS18525 ENOG4105CUW cytochrome C-TYPE protein GPY01_RS18530 ENOG4107QY8 reductase GPY01_RS18545 ENOG4105JQN Transcriptional regulator GPY01_RS18560 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) GPY01_RS18595 ENOG4108HPI phosphatidate Cytidylyltransferase GPY01_RS18605 ENOG4105BZU Histidine kinase GPY01_RS18620 ENOG4105CNG UPF0061 protein GPY01_RS18625 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit GPY01_RS18630 ENOG410835K Tripartite ATP-Independent Periplasmic transporter DctQ GPY01_RS18635 ENOG4105CG6 trap dicarboxylate transporter dctm subunit GPY01_RS18640 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GPY01_RS18655 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation GPY01_RS18660 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GPY01_RS18665 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) GPY01_RS18670 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) GPY01_RS18675 ENOG4105K70 DNA-binding protein GPY01_RS18680 ENOG4105EIN peptidylprolyl cis-trans isomerase GPY01_RS18685 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein GPY01_RS18690 ENOG4105CAT Cytidine monophosphate kinase GPY01_RS18695 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) GPY01_RS18700 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) GPY01_RS18705 ENOG4105Q4A inner membrane protein yciS GPY01_RS18710 ENOG4105CFV Tetratricopeptide repeat protein GPY01_RS18715 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) GPY01_RS18725 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component GPY01_RS18730 ENOG4107QRA Extracellular solute-binding protein, family 5