locus-tag	class	description
EN18_RS00005	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EN18_RS00010	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EN18_RS00020	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EN18_RS00030	COG1489	DNA binding
EN18_RS00040	COG1643	Atp-dependent helicase
EN18_RS00045	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EN18_RS00050	COG1752	Esterase of the alpha-beta hydrolase superfamily
EN18_RS00055	COG1049	propionate catabolic process, 2-methylcitrate cycle
EN18_RS00060	COG3112	Uncharacterised protein family (UPF0231)
EN18_RS00065	COG0347	Belongs to the P(II) protein family
EN18_RS00070	COG0004	ammonium transporteR
EN18_RS00075	COG1840	ABC-type Fe3 transport system, periplasmic component
EN18_RS00085	COG3842	ATPase activity
EN18_RS00105	COG2971	BadF BadG BcrA BcrD
EN18_RS00115	COG4608	Belongs to the ABC transporter superfamily
EN18_RS00120	COG0444	Belongs to the ABC transporter superfamily
EN18_RS00125	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EN18_RS00130	COG0601	transmembrane transport
EN18_RS00135	COG0747	negative chemotaxis
EN18_RS00145	COG2205	protein histidine kinase activity
EN18_RS00145	COG0784	Response regulator, receiver
EN18_RS00150	COG2813	Specifically methylates the guanine in position
EN18_RS00155	COG0628	permease
EN18_RS00165	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EN18_RS00175	COG0316	Belongs to the HesB IscA family
EN18_RS00190	COG0739	heme binding
EN18_RS00195	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EN18_RS00200	COG2027	D-alanyl-D-alanine carboxypeptidase
EN18_RS00205	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EN18_RS00210	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EN18_RS00215	COG1534	Rna-binding protein
EN18_RS00220	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
EN18_RS00225	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EN18_RS00230	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EN18_RS00240	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EN18_RS00255	COG0779	Required for maturation of 30S ribosomal subunits
EN18_RS00260	COG0195	Participates in both transcription termination and antitermination
EN18_RS00265	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EN18_RS00270	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EN18_RS00280	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EN18_RS00305	COG0826	peptidase U32
EN18_RS00310	COG0826	peptidase U32
EN18_RS00320	COG3154	lipid carrier protein
EN18_RS00325	COG3153	acetyltransferase
EN18_RS00490	COG3328	transposase activity
EN18_RS00580	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EN18_RS00595	COG0681	Belongs to the peptidase S26 family
EN18_RS00635	COG2356	endonuclease I
EN18_RS00650	COG0629	single-stranded DNA binding
EN18_RS00665	COG0714	Associated with various cellular activities
EN18_RS00690	COG2003	Belongs to the UPF0758 family
EN18_RS00805	COG0513	Belongs to the DEAD box helicase family
EN18_RS00820	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
EN18_RS00825	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EN18_RS00830	COG2204	response regulator
EN18_RS00840	COG0667	Aldo Keto reductase
EN18_RS00855	COG0494	nUDIX hydrolase
EN18_RS00860	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
EN18_RS00865	COG0730	response to heat
EN18_RS00870	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EN18_RS00880	COG1283	sodium-dependent phosphate transmembrane transporter activity
EN18_RS00885	COG0583	DNA-binding transcription factor activity
EN18_RS00890	COG0640	Transcriptional regulator
EN18_RS00895	COG0268	Binds directly to 16S ribosomal RNA
EN18_RS00900	COG0728	peptidoglycan biosynthetic process
EN18_RS00905	COG0196	riboflavin kinase activity
EN18_RS00920	COG1047	Peptidyl-prolyl cis-trans
EN18_RS00925	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EN18_RS00930	COG1966	Carbon starvation protein
EN18_RS00945	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EN18_RS00950	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EN18_RS00960	COG3279	Response regulator of the LytR AlgR family
EN18_RS00965	COG3275	phosphorelay sensor kinase activity
EN18_RS00970	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EN18_RS00975	COG0287	Prephenate dehydrogenase
EN18_RS00975	COG1605	Chorismate mutase
EN18_RS00985	COG0488	(ABC) transporter
EN18_RS00995	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
EN18_RS01005	COG5001	Diguanylate cyclase
EN18_RS01010	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EN18_RS01015	COG1605	Chorismate mutase
EN18_RS01015	COG0077	Prephenate dehydratase
EN18_RS01020	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EN18_RS01025	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EN18_RS01030	COG0564	pseudouridine synthase activity
EN18_RS01040	COG0542	response to heat
EN18_RS01080	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EN18_RS01085	COG0826	peptidase U32
EN18_RS01095	COG0745	RESPONSE REGULATOR receiver
EN18_RS01100	COG5002	protein histidine kinase activity
EN18_RS01110	COG0248	Ppx GppA phosphatase
EN18_RS01115	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EN18_RS01125	COG0581	inorganic phosphate transmembrane transporter activity
EN18_RS01130	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EN18_RS01145	COG3142	Participates in the control of copper homeostasis
EN18_RS01150	COG0450	alkyl hydroperoxide reductase
EN18_RS01155	COG0583	DNA-binding transcription factor activity
EN18_RS01160	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EN18_RS01170	COG0517	IMP dehydrogenase activity
EN18_RS01190	COG1862	Preprotein translocase
EN18_RS01195	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EN18_RS01200	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EN18_RS01205	COG0483	inositol monophosphate 1-phosphatase activity
EN18_RS01215	COG1959	2 iron, 2 sulfur cluster binding
EN18_RS01220	COG1104	cysteine desulfurase activity
EN18_RS01225	COG0822	iron-sulfur transferase activity
EN18_RS01235	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
EN18_RS01240	COG0443	Heat shock 70 kDa protein
EN18_RS01245	COG0633	Ferredoxin
EN18_RS01250	COG2975	iron-sulfur cluster assembly
EN18_RS01255	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EN18_RS01260	COG0105	UTP biosynthetic process
EN18_RS01265	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EN18_RS01275	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EN18_RS01280	COG0124	histidyl-tRNA synthetase
EN18_RS01285	COG2976	Protein conserved in bacteria
EN18_RS01290	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EN18_RS01295	COG1160	GTP binding
EN18_RS01310	COG1570	exodeoxyribonuclease VII activity
EN18_RS01315	COG0516	GMP reductase activity
EN18_RS01315	COG0517	IMP dehydrogenase activity
EN18_RS01320	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EN18_RS01320	COG0519	Catalyzes the synthesis of GMP from XMP
EN18_RS01330	COG1584	GPR1 FUN34 yaaH family protein
EN18_RS01335	COG3433	isochorismatase activity
EN18_RS01335	COG1535	isochorismatase
EN18_RS01340	COG1021	2,3-dihydroxybenzoate-AMP ligase
EN18_RS01345	COG1169	isochorismate synthase
EN18_RS01350	COG1028	Short-chain dehydrogenase reductase Sdr
EN18_RS01360	COG4592	Periplasmic binding protein
EN18_RS01365	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EN18_RS01370	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EN18_RS01375	COG1120	ATPase activity
EN18_RS01385	COG0583	DNA-binding transcription factor activity
EN18_RS01390	COG2015	COG2015, Alkyl sulfatase and related hydrolases
EN18_RS01395	COG1115	amino acid carrier protein
EN18_RS01405	COG0583	DNA-binding transcription factor activity
EN18_RS01420	COG4565	transcriptional regulatory protein
EN18_RS01430	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
EN18_RS01435	COG0511	ligase activity, forming carbon-carbon bonds
EN18_RS01435	COG5016	pyruvate
EN18_RS01440	COG3630	sodium ion export across plasma membrane
EN18_RS01450	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
EN18_RS01460	COG2301	Belongs to the HpcH HpaI aldolase family
EN18_RS01465	COG3051	citrate lyase alpha subunit
EN18_RS01485	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EN18_RS01490	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
EN18_RS01495	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
EN18_RS01565	COG1012	belongs to the aldehyde dehydrogenase family
EN18_RS01585	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
EN18_RS01590	COG0840	transmembrane signaling receptor activity
EN18_RS01595	COG3710	Transcriptional regulator
EN18_RS01605	COG2165	general secretion pathway protein
EN18_RS01620	COG4796	Type ii and iii secretion system protein
EN18_RS01640	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EN18_RS01645	COG1459	type II secretion system
EN18_RS01655	COG2207	Transcriptional regulator
EN18_RS01660	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
EN18_RS01680	COG0739	heme binding
EN18_RS01690	COG3064	Membrane
EN18_RS01700	COG0582	viral genome integration into host DNA
EN18_RS01705	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EN18_RS01710	COG2867	negative regulation of translational initiation
EN18_RS01715	COG2914	Belongs to the UPF0125 (RnfH) family
EN18_RS01720	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EN18_RS01725	COG0497	DNA recombination
EN18_RS01730	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EN18_RS01735	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EN18_RS01740	COG0443	Heat shock 70 kDa protein
EN18_RS01745	COG0484	heat shock protein binding
EN18_RS01780	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
EN18_RS01795	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
EN18_RS01805	COG0047	phosphoribosylformylglycinamidine synthase activity
EN18_RS01805	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EN18_RS01835	COG0442	prolyl-tRNA aminoacylation
EN18_RS01840	COG1720	tRNA m6t6A37 methyltransferase activity
EN18_RS01845	COG0254	rRNA binding
EN18_RS01850	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EN18_RS01855	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
EN18_RS01860	COG1671	Belongs to the UPF0178 family
EN18_RS01870	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EN18_RS01885	COG3098	single-species biofilm formation
EN18_RS01890	COG0564	pseudouridine synthase activity
EN18_RS01895	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EN18_RS01900	COG0142	geranyltranstransferase activity
EN18_RS01905	COG1722	exodeoxyribonuclease VII activity
EN18_RS01910	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EN18_RS01920	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EN18_RS01920	COG0301	tRNA thio-modification
EN18_RS01930	COG0583	DNA-binding transcription factor activity
EN18_RS01935	COG2363	Small membrane protein
EN18_RS01940	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EN18_RS01945	COG1611	Belongs to the LOG family
EN18_RS01960	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EN18_RS01960	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EN18_RS01970	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
EN18_RS01975	COG1464	Belongs to the NlpA lipoprotein family
EN18_RS01980	COG2011	ABC-type metal ion transport system permease component
EN18_RS01985	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EN18_RS01990	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EN18_RS01995	COG1609	Transcriptional regulator
EN18_RS02000	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EN18_RS02000	COG1263	PTS System
EN18_RS02005	COG0366	Alpha amylase catalytic
EN18_RS02035	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EN18_RS02040	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EN18_RS02045	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
EN18_RS02050	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
EN18_RS02055	COG0110	maltose O-acetyltransferase activity
EN18_RS02075	COG1045	serine acetyltransferase
EN18_RS02085	COG0438	transferase activity, transferring glycosyl groups
EN18_RS02095	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
EN18_RS02125	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EN18_RS02135	COG1596	polysaccharide export
EN18_RS02160	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EN18_RS02170	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EN18_RS02175	COG0321	lipoyl(octanoyl) transferase activity
EN18_RS02180	COG2921	Belongs to the UPF0250 family
EN18_RS02190	COG1686	Belongs to the peptidase S11 family
EN18_RS02195	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EN18_RS02200	COG0772	Belongs to the SEDS family
EN18_RS02205	COG0768	penicillin binding
EN18_RS02210	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EN18_RS02215	COG0799	negative regulation of ribosome biogenesis
EN18_RS02220	COG1466	dna polymerase III delta subunit
EN18_RS02225	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
EN18_RS02230	COG0495	leucyl-tRNA aminoacylation
EN18_RS02235	COG2888	peptidyl-tyrosine sulfation
EN18_RS02240	COG0815	Transfers the fatty acyl group on membrane lipoproteins
EN18_RS02245	COG4535	Mg2 and Co2 transporter CorC
EN18_RS02255	COG1702	phosphate starvation-inducible protein PhoH
EN18_RS02260	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EN18_RS02265	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EN18_RS02270	COG2190	(PTS) system
EN18_RS02280	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EN18_RS02290	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EN18_RS02295	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
EN18_RS02300	COG3115	cell septum assembly
EN18_RS02305	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EN18_RS02320	COG0789	Transcriptional regulator
EN18_RS02325	COG1585	Membrane protein implicated in regulation of membrane protease activity
EN18_RS02330	COG0330	HflC and HflK could
EN18_RS02335	COG3118	belongs to the thioredoxin family
EN18_RS02340	COG0300	oxidoreductase activity
EN18_RS02345	COG1090	epimerase
EN18_RS02350	COG0622	Phosphoesterase
EN18_RS02365	COG3710	Transcriptional regulator
EN18_RS02370	COG0326	Molecular chaperone. Has ATPase activity
EN18_RS02375	COG0563	adenylate kinase activity
EN18_RS02380	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EN18_RS02395	COG0367	asparagine synthase
EN18_RS02400	COG4651	solute:proton antiporter activity
EN18_RS02400	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EN18_RS02405	COG1940	carbohydrate kinase activity
EN18_RS02405	COG1846	Transcriptional regulator
EN18_RS02410	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EN18_RS02415	COG1263	PTS System
EN18_RS02415	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EN18_RS02415	COG2190	(PTS) system
EN18_RS02430	COG0101	tRNA pseudouridine synthase activity
EN18_RS02435	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EN18_RS02440	COG0285	dihydrofolate synthase activity
EN18_RS02445	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
EN18_RS02450	COG1286	toxin biosynthetic process
EN18_RS02455	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EN18_RS02460	COG2056	Na+-H+ antiporter family
EN18_RS02465	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EN18_RS02485	COG0346	lactoylglutathione lyase activity
EN18_RS02490	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EN18_RS02510	COG4656	Part of a membrane complex involved in electron transport
EN18_RS02515	COG2878	Part of a membrane complex involved in electron transport
EN18_RS02520	COG4657	Part of a membrane complex involved in electron transport
EN18_RS02530	COG0556	nucleotide-excision repair
EN18_RS02540	COG2204	response regulator
EN18_RS02545	COG2198	Histidine kinase
EN18_RS02550	COG0391	Required for morphogenesis under gluconeogenic growth conditions
EN18_RS02555	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EN18_RS02560	COG0521	Mo-molybdopterin cofactor biosynthetic process
EN18_RS02565	COG0315	cyclic pyranopterin monophosphate synthase activity
EN18_RS02570	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
EN18_RS02575	COG0314	molybdopterin synthase activity
EN18_RS02580	COG2199	diguanylate cyclase activity
EN18_RS02585	COG0517	IMP dehydrogenase activity
EN18_RS02585	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EN18_RS02585	COG0617	tRNA 3'-terminal CCA addition
EN18_RS02600	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
EN18_RS02610	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EN18_RS02610	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EN18_RS02615	COG0489	protein tyrosine kinase activity
EN18_RS02625	COG0572	uridine kinase
EN18_RS02630	COG2982	Protein involved in outer membrane biogenesis
EN18_RS02635	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
EN18_RS02640	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EN18_RS02650	COG2067	long-chain fatty acid transport protein
EN18_RS02670	COG0183	Belongs to the thiolase family
EN18_RS02675	COG1250	3-hydroxyacyl-CoA dehydrogenase
EN18_RS02675	COG1024	Enoyl-CoA hydratase
EN18_RS02680	COG0778	Nitroreductase
EN18_RS02685	COG0583	DNA-binding transcription factor activity
EN18_RS02690	COG0745	RESPONSE REGULATOR receiver
EN18_RS02700	COG2832	Protein of unknown function (DUF454)
EN18_RS02705	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EN18_RS02715	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EN18_RS02720	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EN18_RS02730	COG2983	Belongs to the UPF0260 family
EN18_RS02735	COG1028	Short-chain dehydrogenase reductase Sdr
EN18_RS02740	COG0616	signal peptide processing
EN18_RS02750	COG1522	sequence-specific DNA binding
EN18_RS02755	COG1946	Acyl-CoA thioesterase
EN18_RS02775	COG3706	GGDEF domain
EN18_RS02780	COG0640	Transcriptional regulator
EN18_RS02785	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EN18_RS02810	COG1881	PFAM PEBP family protein
EN18_RS02830	COG0009	L-threonylcarbamoyladenylate synthase
EN18_RS02845	COG2201	protein-glutamate methylesterase activity
EN18_RS02855	COG5002	protein histidine kinase activity
EN18_RS02860	COG4191	Histidine kinase
EN18_RS02865	COG3300	MHYT domain
EN18_RS02865	COG5001	Diguanylate cyclase
EN18_RS02870	COG2204	response regulator
EN18_RS02890	COG0601	transmembrane transport
EN18_RS02895	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EN18_RS02900	COG0444	Belongs to the ABC transporter superfamily
EN18_RS02905	COG4608	Belongs to the ABC transporter superfamily
EN18_RS02910	COG0435	Glutathione S-transferase
EN18_RS02915	COG0857	belongs to the CobB CobQ family
EN18_RS02915	COG0280	phosphate acetyltransferase
EN18_RS02920	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EN18_RS02925	COG3092	negative regulation of chromosome organization
EN18_RS02930	COG4628	conserved protein (DUF2132)
EN18_RS02940	COG4120	Belongs to the binding-protein-dependent transport system permease family
EN18_RS02950	COG2199	diguanylate cyclase activity
EN18_RS02950	COG2203	Gaf domain
EN18_RS02955	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EN18_RS02965	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EN18_RS02970	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EN18_RS02975	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EN18_RS02980	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EN18_RS02985	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EN18_RS02990	COG0156	8-amino-7-oxononanoate synthase activity
EN18_RS02995	COG2226	methyltransferase
EN18_RS03000	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
EN18_RS03010	COG0501	Belongs to the peptidase M48B family
EN18_RS03020	COG0300	oxidoreductase activity
EN18_RS03035	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EN18_RS03045	COG2268	Band 7 protein
EN18_RS03055	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EN18_RS03060	COG2915	High frequency lysogenization protein hflD homolog
EN18_RS03065	COG0482	sulfurtransferase activity
EN18_RS03070	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EN18_RS03075	COG2916	Histone family protein nucleoid-structuring protein H-NS
EN18_RS03080	COG1757	Na H antiporter
EN18_RS03085	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EN18_RS03090	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EN18_RS03095	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EN18_RS03100	COG0131	Imidazoleglycerol-phosphate dehydratase
EN18_RS03100	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EN18_RS03105	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EN18_RS03110	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EN18_RS03115	COG0107	imidazoleglycerol-phosphate synthase activity
EN18_RS03120	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EN18_RS03120	COG0140	phosphoribosyl-ATP diphosphatase activity
EN18_RS03125	COG1187	pseudouridine synthase activity
EN18_RS03135	COG1278	Cold shock
EN18_RS03140	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
EN18_RS03145	COG0542	response to heat
EN18_RS03150	COG3273	potassium ion transport
EN18_RS03150	COG2985	domain, Protein
EN18_RS03155	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EN18_RS03160	COG1012	belongs to the aldehyde dehydrogenase family
EN18_RS03160	COG1454	alcohol dehydrogenase
EN18_RS03165	COG1737	Transcriptional regulator
EN18_RS03170	COG0076	glutamate decarboxylase activity
EN18_RS03180	COG2431	L-lysine efflux transmembrane transporter activity
EN18_RS03190	COG3070	regulator of competence-specific genes
EN18_RS03205	COG3852	Histidine kinase
EN18_RS03215	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
EN18_RS03230	COG0189	ligase activity
EN18_RS03230	COG4067	protein conserved in archaea
EN18_RS03235	COG0500	methyltransferase
EN18_RS03240	COG4106	trans-aconitate 2-methyltransferase activity
EN18_RS03245	COG1801	Protein of unknown function DUF72
EN18_RS03250	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EN18_RS03255	COG1435	thymidine kinase activity
EN18_RS03265	COG0159	tryptophan synthase activity
EN18_RS03270	COG0133	tryptophan synthase activity
EN18_RS03275	COG0135	phosphoribosylanthranilate isomerase activity
EN18_RS03275	COG0134	indole-3-glycerol-phosphate synthase activity
EN18_RS03280	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EN18_RS03285	COG0512	Glutamine amidotransferase of anthranilate synthase
EN18_RS03290	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EN18_RS03300	COG0613	PHP domain protein
EN18_RS03305	COG0009	L-threonylcarbamoyladenylate synthase
EN18_RS03310	COG1187	pseudouridine synthase activity
EN18_RS03315	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EN18_RS03320	COG4988	ABC transporter
EN18_RS03325	COG0492	ferredoxin-NADP+ reductase activity
EN18_RS03335	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EN18_RS03340	COG3706	GGDEF domain
EN18_RS03345	COG2949	membrane
EN18_RS03355	COG0281	malic enzyme
EN18_RS03365	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EN18_RS03385	COG2885	chlorophyll binding
EN18_RS03400	COG0277	FAD linked oxidase domain protein
EN18_RS03400	COG0247	lactate metabolic process
EN18_RS03420	COG2986	histidine ammonia-lyase
EN18_RS03425	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
EN18_RS03430	COG0010	Belongs to the arginase family
EN18_RS03435	COG1228	amidohydrolase
EN18_RS03450	COG3099	Belongs to the UPF0263 family
EN18_RS03455	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EN18_RS03465	COG5001	Diguanylate cyclase
EN18_RS03470	COG0417	DNA replication proofreading
EN18_RS03475	COG2197	response regulator
EN18_RS03480	COG0322	excinuclease ABC activity
EN18_RS03520	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EN18_RS03525	COG0072	phenylalanine-tRNA ligase activity
EN18_RS03525	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EN18_RS03530	COG0776	regulation of translation
EN18_RS03570	COG1346	cytolysis
EN18_RS03575	COG1380	Effector of murein hydrolase LrgA
EN18_RS03580	COG2925	Exonuclease
EN18_RS03585	COG1823	symporter activity
EN18_RS03590	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EN18_RS03595	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
EN18_RS03600	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
EN18_RS03620	COG4139	cobalamin transport
EN18_RS03670	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EN18_RS03675	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EN18_RS03680	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EN18_RS03690	COG1054	Belongs to the UPF0176 family
EN18_RS03700	COG2814	Major facilitator Superfamily
EN18_RS03710	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EN18_RS03735	COG2989	Protein conserved in bacteria
EN18_RS03740	COG3108	Peptidase M15
EN18_RS03745	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EN18_RS03760	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EN18_RS03785	COG1846	Transcriptional regulator
EN18_RS03790	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EN18_RS03795	COG0726	polysaccharide deacetylase
EN18_RS03800	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EN18_RS03810	COG1447	Phosphotransferase system cellobiose-specific component IIA
EN18_RS03815	COG1486	melibiose metabolic process
EN18_RS03825	COG1609	Transcriptional regulator
EN18_RS03830	COG2943	transferase activity, transferring hexosyl groups
EN18_RS03835	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
EN18_RS03840	COG0840	transmembrane signaling receptor activity
EN18_RS03855	COG1448	Aminotransferase
EN18_RS03865	COG2770	Histidine kinase
EN18_RS03865	COG3437	response regulator, receiver
EN18_RS03870	COG0351	phosphomethylpyrimidine kinase
EN18_RS03875	COG0017	Asparaginyl-tRNA synthetase
EN18_RS03880	COG0840	transmembrane signaling receptor activity
EN18_RS03885	COG0720	synthase
EN18_RS03890	COG1760	l-serine dehydratase
EN18_RS03895	COG0814	amino acid
EN18_RS03900	COG0494	nUDIX hydrolase
EN18_RS03905	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EN18_RS03920	COG3106	COG3106 Predicted ATPase
EN18_RS03925	COG3768	UPF0283 membrane protein
EN18_RS03935	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EN18_RS03950	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EN18_RS03960	COG0471	metal ion transport
EN18_RS03965	COG4191	Histidine kinase
EN18_RS03965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EN18_RS03975	COG2990	Protein conserved in bacteria
EN18_RS03980	COG3713	MltA-interacting MipA family protein
EN18_RS03985	COG2205	protein histidine kinase activity
EN18_RS03990	COG0745	RESPONSE REGULATOR receiver
EN18_RS04025	COG1129	ABC transporter
EN18_RS04065	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
EN18_RS04070	COG0372	Belongs to the citrate synthase family
EN18_RS04100	COG2195	Cleaves the N-terminal amino acid of tripeptides
EN18_RS04110	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
EN18_RS04120	COG0625	glutathione transferase activity
EN18_RS04125	COG3437	response regulator, receiver
EN18_RS04145	COG3706	GGDEF domain
EN18_RS04150	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EN18_RS04155	COG1254	Belongs to the acylphosphatase family
EN18_RS04160	COG2920	part of a sulfur-relay system
EN18_RS04165	COG0670	Belongs to the BI1 family
EN18_RS04170	COG1126	abc transporter atp-binding protein
EN18_RS04175	COG0765	amino acid transport
EN18_RS04180	COG4597	amino acid ABC transporter
EN18_RS04185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EN18_RS04195	COG0561	phosphatase activity
EN18_RS04200	COG0602	queuosine metabolic process
EN18_RS04205	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EN18_RS04235	COG3706	GGDEF domain
EN18_RS04240	COG0443	Heat shock 70 kDa protein
EN18_RS04245	COG0443	Heat shock 70 kDa protein
EN18_RS04285	COG1643	Atp-dependent helicase
EN18_RS04295	COG0443	Heat shock 70 kDa protein
EN18_RS04300	COG0095	Lipoate-protein ligase
EN18_RS04310	COG0583	DNA-binding transcription factor activity
EN18_RS04315	COG0477	Major facilitator Superfamily
EN18_RS04320	COG0415	Belongs to the DNA photolyase family
EN18_RS04335	COG0745	RESPONSE REGULATOR receiver
EN18_RS04345	COG2198	Histidine kinase
EN18_RS04345	COG0643	Histidine kinase
EN18_RS04350	COG0643	Histidine kinase
EN18_RS04350	COG0784	Response regulator, receiver
EN18_RS04350	COG2198	Histidine kinase
EN18_RS04355	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EN18_RS04365	COG2201	protein-glutamate methylesterase activity
EN18_RS04370	COG0835	chemotaxis
EN18_RS04375	COG3290	protein histidine kinase activity
EN18_RS04375	COG0840	transmembrane signaling receptor activity
EN18_RS04380	COG0840	transmembrane signaling receptor activity
EN18_RS04390	COG0513	Belongs to the DEAD box helicase family
EN18_RS04400	COG1538	Outer membrane efflux protein
EN18_RS04405	COG1566	PFAM secretion protein HlyD family protein
EN18_RS04410	COG2814	Major facilitator Superfamily
EN18_RS04420	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
EN18_RS04430	COG3501	Rhs element vgr protein
EN18_RS04440	COG3675	Pfam Lipase (class 3)
EN18_RS04455	COG1280	lysine exporter protein (LysE YggA)
EN18_RS04460	COG1115	amino acid carrier protein
EN18_RS04475	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EN18_RS04485	COG1177	transmembrane transport
EN18_RS04495	COG3842	ATPase activity
EN18_RS04520	COG0589	response to stress
EN18_RS04525	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EN18_RS04540	COG2217	Heavy metal translocating P-type atpase
EN18_RS04550	COG2010	Cytochrome c
EN18_RS04565	COG3278	Belongs to the heme-copper respiratory oxidase family
EN18_RS04580	COG2205	protein histidine kinase activity
EN18_RS04580	COG0784	Response regulator, receiver
EN18_RS04605	COG2994	toxin metabolic process
EN18_RS04610	COG3064	Membrane
EN18_RS04610	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
EN18_RS04610	COG1073	alpha beta
EN18_RS04625	COG4128	Pfam Zonular occludens toxin
EN18_RS04655	COG1476	TRANSCRIPTIONal
EN18_RS04675	COG1476	TRANSCRIPTIONal
EN18_RS04725	COG3328	transposase activity
EN18_RS04745	COG3120	sequence-specific DNA binding
EN18_RS04750	COG1067	ATP-dependent peptidase activity
EN18_RS04755	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EN18_RS04770	COG0488	(ABC) transporter
EN18_RS04780	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EN18_RS04780	COG0116	Belongs to the methyltransferase superfamily
EN18_RS04790	COG0167	dihydroorotate dehydrogenase activity
EN18_RS04805	COG0308	aminopeptidase N
EN18_RS04820	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
EN18_RS04825	COG1956	GAF domain-containing protein
EN18_RS04830	COG1132	(ABC) transporter
EN18_RS04835	COG2995	paraquat-inducible protein a
EN18_RS04840	COG3008	intermembrane lipid transfer
EN18_RS04850	COG2996	Protein conserved in bacteria
EN18_RS04865	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EN18_RS04870	COG1666	GTP binding
EN18_RS04875	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EN18_RS04890	COG0437	4 iron, 4 sulfur cluster binding
EN18_RS04895	COG0243	molybdopterin cofactor binding
EN18_RS04895	COG3383	formate dehydrogenase (NAD+) activity
EN18_RS04925	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EN18_RS04930	COG0488	(ABC) transporter
EN18_RS04935	COG3852	Histidine kinase
EN18_RS04940	COG2204	response regulator
EN18_RS04950	COG4662	Binding-protein-dependent transport system inner membrane component
EN18_RS04955	COG3842	ATPase activity
EN18_RS04960	COG0746	molybdenum cofactor guanylyltransferase activity
EN18_RS04990	COG1940	carbohydrate kinase activity
EN18_RS04995	COG3148	PFAM DTW domain containing protein
EN18_RS05005	COG0840	transmembrane signaling receptor activity
EN18_RS05010	COG0791	NLP P60 protein
EN18_RS05020	COG3001	Fructosamine kinase
EN18_RS05030	COG0534	Mate efflux family protein
EN18_RS05040	COG1793	dna ligase
EN18_RS05050	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
EN18_RS05055	COG0848	biopolymer transport protein
EN18_RS05060	COG0811	peptide transport
EN18_RS05065	COG0811	peptide transport
EN18_RS05080	COG1175	transmembrane transport
EN18_RS05085	COG0395	ABC-type sugar transport system, permease component
EN18_RS05090	COG3842	ATPase activity
EN18_RS05095	COG1349	DNA-binding transcription factor activity
EN18_RS05100	COG0584	glycerophosphoryl diester phosphodiesterase
EN18_RS05105	COG2731	YhcH YjgK YiaL family protein
EN18_RS05110	COG0251	oxidation-reduction process
EN18_RS05115	COG1609	Transcriptional regulator
EN18_RS05120	COG2723	6-phospho-beta-galactosidase activity
EN18_RS05130	COG0583	DNA-binding transcription factor activity
EN18_RS05150	COG0577	efflux transmembrane transporter activity
EN18_RS05150	COG1136	(ABC) transporter
EN18_RS05155	COG1136	(ABC) transporter
EN18_RS05155	COG0577	efflux transmembrane transporter activity
EN18_RS05160	COG4591	ABC-type transport system involved in lipoprotein release permease component
EN18_RS05160	COG1136	(ABC) transporter
EN18_RS05165	COG1294	oxidase, subunit
EN18_RS05170	COG1271	oxidase subunit
EN18_RS05210	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EN18_RS05220	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EN18_RS05240	COG0753	catalase activity
EN18_RS05270	COG2200	EAL domain
EN18_RS05270	COG2199	diguanylate cyclase activity
EN18_RS05280	COG2017	converts alpha-aldose to the beta-anomer
EN18_RS05285	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
EN18_RS05290	COG1085	galactose-1-phosphate uridylyltransferase
EN18_RS05330	COG0784	Response regulator, receiver
EN18_RS05330	COG0835	chemotaxis
EN18_RS05340	COG4565	transcriptional regulatory protein
EN18_RS05345	COG3290	protein histidine kinase activity
EN18_RS05360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EN18_RS05380	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
EN18_RS05385	COG3063	Type IV pilus biogenesis stability protein PilW
EN18_RS05395	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
EN18_RS05400	COG1451	nucleotide metabolic process
EN18_RS05410	COG0583	DNA-binding transcription factor activity
EN18_RS05430	COG1538	Outer membrane efflux protein
EN18_RS05445	COG1748	Saccharopine dehydrogenase
EN18_RS05455	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EN18_RS05465	COG0577	efflux transmembrane transporter activity
EN18_RS05470	COG4181	ATPase activity
EN18_RS05475	COG0534	Mate efflux family protein
EN18_RS05480	COG0702	epimerase
EN18_RS05490	COG2814	Major facilitator Superfamily
EN18_RS05495	COG1187	pseudouridine synthase activity
EN18_RS05500	COG1061	Type III restriction enzyme res subunit
EN18_RS05520	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
EN18_RS05525	COG3706	GGDEF domain
EN18_RS05525	COG5001	Diguanylate cyclase
EN18_RS05525	COG2203	Gaf domain
EN18_RS05525	COG4251	negative regulation of phosphorylation
EN18_RS05540	COG0840	transmembrane signaling receptor activity
EN18_RS05570	COG4934	collagen metabolic process
EN18_RS05585	COG0784	Response regulator, receiver
EN18_RS05585	COG2205	protein histidine kinase activity
EN18_RS05590	COG2239	Acts as a magnesium transporter
EN18_RS05600	COG0814	amino acid
EN18_RS05605	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EN18_RS05610	COG1131	(ABC) transporter
EN18_RS05615	COG0842	Transport permease protein
EN18_RS05625	COG3313	Fe-S protein
EN18_RS05635	COG4134	Bacterial extracellular solute-binding protein
EN18_RS05640	COG4135	transport system, permease component
EN18_RS05645	COG4136	ATPase activity
EN18_RS05650	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EN18_RS05655	COG0564	pseudouridine synthase activity
EN18_RS05660	COG0733	neurotransmitter:sodium symporter activity
EN18_RS05670	COG0626	cystathionine gamma-synthase activity
EN18_RS05675	COG2818	Glycosylase
EN18_RS05690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EN18_RS05705	COG1842	Phage shock protein A
EN18_RS05710	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
EN18_RS05720	COG4168	peptide transport system, permease
EN18_RS05735	COG4172	Belongs to the ABC transporter superfamily
EN18_RS05750	COG1227	inorganic diphosphatase activity
EN18_RS05770	COG0243	molybdopterin cofactor binding
EN18_RS05775	COG3005	denitrification pathway
EN18_RS05780	COG4459	periplasmic nitrate reductase
EN18_RS05790	COG2116	formate transmembrane transporter activity
EN18_RS05800	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EN18_RS05805	COG1434	Gram-negative-bacterium-type cell wall biogenesis
EN18_RS05820	COG1607	acyl-coa hydrolase
EN18_RS05825	COG2350	Protein conserved in bacteria
EN18_RS05835	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EN18_RS05840	COG0583	DNA-binding transcription factor activity
EN18_RS05855	COG0612	Peptidase, M16
EN18_RS05860	COG5001	Diguanylate cyclase
EN18_RS05865	COG1032	radical SAM domain protein
EN18_RS05885	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
EN18_RS05895	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EN18_RS05900	COG1434	Gram-negative-bacterium-type cell wall biogenesis
EN18_RS05905	COG0745	RESPONSE REGULATOR receiver
EN18_RS05910	COG3381	protein complex oligomerization
EN18_RS05915	COG1609	Transcriptional regulator
EN18_RS05920	COG3070	regulator of competence-specific genes
EN18_RS05940	COG0297	glycogen (starch) synthase activity
EN18_RS05945	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EN18_RS05950	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EN18_RS05980	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EN18_RS05985	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EN18_RS06010	COG1012	belongs to the aldehyde dehydrogenase family
EN18_RS06015	COG1309	transcriptional regulator
EN18_RS06040	COG0668	transmembrane transport
EN18_RS06045	COG2995	paraquat-inducible protein a
EN18_RS06050	COG3008	intermembrane lipid transfer
EN18_RS06050	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EN18_RS06060	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EN18_RS06075	COG0582	viral genome integration into host DNA
EN18_RS06085	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EN18_RS06105	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
EN18_RS06125	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
EN18_RS06145	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
EN18_RS06150	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
EN18_RS06155	COG1737	Transcriptional regulator
EN18_RS06160	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EN18_RS06165	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EN18_RS06170	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
EN18_RS06175	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EN18_RS06190	COG1940	carbohydrate kinase activity
EN18_RS06195	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EN18_RS06200	COG4409	exo-alpha-(2->6)-sialidase activity
EN18_RS06210	COG2003	Belongs to the UPF0758 family
EN18_RS06230	COG3941	tape measure
EN18_RS06270	COG0488	(ABC) transporter
EN18_RS06345	COG0415	Belongs to the DNA photolyase family
EN18_RS06355	COG4628	conserved protein (DUF2132)
EN18_RS06360	COG3284	Transcriptional regulator
EN18_RS06365	COG1012	belongs to the aldehyde dehydrogenase family
EN18_RS06375	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EN18_RS06380	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EN18_RS06385	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EN18_RS06395	COG2207	Transcriptional regulator
EN18_RS06400	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EN18_RS06400	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EN18_RS06400	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EN18_RS06405	COG1482	cell wall glycoprotein biosynthetic process
EN18_RS06415	COG5002	protein histidine kinase activity
EN18_RS06415	COG0784	Response regulator, receiver
EN18_RS06425	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EN18_RS06435	COG2885	chlorophyll binding
EN18_RS06440	COG0823	Involved in the tonB-independent uptake of proteins
EN18_RS06455	COG0811	peptide transport
EN18_RS06460	COG0824	Thioesterase
EN18_RS06465	COG3790	cyd operon protein YbgE
EN18_RS06470	COG4890	Cyd operon protein YbgT
EN18_RS06475	COG1294	oxidase, subunit
EN18_RS06480	COG1271	oxidase subunit
EN18_RS06490	COG0632	four-way junction helicase activity
EN18_RS06495	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
EN18_RS06500	COG0215	cysteine-tRNA ligase activity
EN18_RS06505	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EN18_RS06510	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EN18_RS06515	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
EN18_RS06520	COG3012	SEC-C Motif Domain Protein
EN18_RS06525	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
EN18_RS06530	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EN18_RS06535	COG1199	ATP-dependent helicase activity
EN18_RS06540	COG0730	response to heat
EN18_RS06545	COG3923	Primosomal replication protein n
EN18_RS06555	COG0840	transmembrane signaling receptor activity
EN18_RS06560	COG0708	Exodeoxyribonuclease III
EN18_RS06565	COG4160	amino acid transport
EN18_RS06590	COG1882	Formate acetyltransferase
EN18_RS06600	COG0840	transmembrane signaling receptor activity
EN18_RS06605	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EN18_RS06615	COG3013	Belongs to the UPF0304 family
EN18_RS06620	COG2766	serine protein kinase
EN18_RS06625	COG2718	Belongs to the UPF0229 family
EN18_RS06630	COG2719	SpoVR family
EN18_RS06635	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
EN18_RS06640	COG2835	tetraacyldisaccharide 4'-kinase activity
EN18_RS06645	COG1663	tetraacyldisaccharide 4'-kinase activity
EN18_RS06650	COG1132	(ABC) transporter
EN18_RS06655	COG2333	competence protein COMEC
EN18_RS06655	COG0658	competence protein
EN18_RS06665	COG4591	ABC-type transport system involved in lipoprotein release permease component
EN18_RS06670	COG1136	(ABC) transporter
EN18_RS06675	COG4591	ABC-type transport system involved in lipoprotein release permease component
EN18_RS06685	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EN18_RS06705	COG1252	NADH dehydrogenase
EN18_RS06710	COG3150	esterase
EN18_RS06735	COG0537	adenosine 5'-monophosphoramidase activity
EN18_RS06750	COG2186	Transcriptional regulator
EN18_RS06755	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EN18_RS06760	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
EN18_RS06765	COG1674	ftsk spoiiie
EN18_RS06775	COG0686	Belongs to the AlaDH PNT family
EN18_RS06785	COG0583	DNA-binding transcription factor activity
EN18_RS06805	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
EN18_RS06810	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
EN18_RS06815	COG0776	regulation of translation
EN18_RS06820	COG0539	negative regulation of cytoplasmic translation
EN18_RS06825	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EN18_RS06830	COG1555	photosystem II stabilization
EN18_RS06835	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EN18_RS06840	COG0776	regulation of translation
EN18_RS06845	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EN18_RS06850	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EN18_RS06860	COG0544	peptidyl-prolyl cis-trans isomerase activity
EN18_RS06870	COG4191	Histidine kinase
EN18_RS06880	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EN18_RS06885	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
EN18_RS06890	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EN18_RS06895	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EN18_RS06910	COG3300	MHYT domain
EN18_RS06910	COG5001	Diguanylate cyclase
EN18_RS06920	COG4589	Belongs to the CDS family
EN18_RS06955	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EN18_RS06965	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EN18_RS06980	COG0243	molybdopterin cofactor binding
EN18_RS06985	COG3005	denitrification pathway
EN18_RS06990	COG3469	chitinase activity
EN18_RS06990	COG3325	Belongs to the glycosyl hydrolase 18 family
EN18_RS06995	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EN18_RS07005	COG2951	lytic endotransglycosylase activity
EN18_RS07010	COG3100	YcgL domain-containing protein
EN18_RS07015	COG0850	regulation of cytokinetic process
EN18_RS07020	COG2894	cell division
EN18_RS07025	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
EN18_RS07030	COG3015	lipoprotein NlpE involved in copper resistance
EN18_RS07050	COG0477	Major facilitator Superfamily
EN18_RS07060	COG0840	transmembrane signaling receptor activity
EN18_RS07065	COG1396	sequence-specific DNA binding
EN18_RS07070	COG3135	benzoate transporter
EN18_RS07090	COG0596	Alpha beta hydrolase
EN18_RS07095	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
EN18_RS07100	COG1169	isochorismate synthase
EN18_RS07105	COG0436	Aminotransferase
EN18_RS07110	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
EN18_RS07115	COG0232	Belongs to the dGTPase family. Type 2 subfamily
EN18_RS07135	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
EN18_RS07140	COG0318	PFAM AMP-dependent synthetase and ligase
EN18_RS07145	COG0596	Alpha beta hydrolase
EN18_RS07160	COG1214	PFAM Peptidase M22, glycoprotease
EN18_RS07165	COG1199	ATP-dependent helicase activity
EN18_RS07175	COG0788	formyltetrahydrofolate deformylase activity
EN18_RS07180	COG0446	pyridine nucleotide-disulphide oxidoreductase
EN18_RS07180	COG1902	pentaerythritol trinitrate reductase activity
EN18_RS07185	COG0616	signal peptide processing
EN18_RS07190	COG0252	asparaginase activity
EN18_RS07195	COG3139	Protein of unknown function (DUF1315)
EN18_RS07205	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EN18_RS07210	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EN18_RS07215	COG0676	glucose-6-phosphate 1-epimerase activity
EN18_RS07225	COG2226	methyltransferase
EN18_RS07240	COG0784	Response regulator, receiver
EN18_RS07240	COG0835	chemotaxis
EN18_RS07245	COG1940	carbohydrate kinase activity
EN18_RS07255	COG4667	esterase of the alpha-beta hydrolase superfamily
EN18_RS07270	COG0733	neurotransmitter:sodium symporter activity
EN18_RS07275	COG1263	PTS System
EN18_RS07275	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EN18_RS07280	COG0084	hydrolase, TatD family'
EN18_RS07290	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EN18_RS07295	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EN18_RS07300	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EN18_RS07305	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EN18_RS07310	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EN18_RS07315	COG1028	Short-chain dehydrogenase reductase Sdr
EN18_RS07325	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EN18_RS07330	COG0416	fatty acid biosynthetic process
EN18_RS07335	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EN18_RS07340	COG1399	metal-binding, possibly nucleic acid-binding protein
EN18_RS07345	COG0424	maF-like protein
EN18_RS07350	COG0564	pseudouridine synthase activity
EN18_RS07365	COG1530	ribonuclease E activity
EN18_RS07370	COG0659	secondary active sulfate transmembrane transporter activity
EN18_RS07380	COG1012	belongs to the aldehyde dehydrogenase family
EN18_RS07380	COG1454	alcohol dehydrogenase
EN18_RS07385	COG2095	MarC family integral membrane protein
EN18_RS07390	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EN18_RS07395	COG1757	Na H antiporter
EN18_RS07405	COG3081	Nucleoid-associated protein
EN18_RS07410	COG3082	Protein of unknown function (DUF1414)
EN18_RS07415	COG3083	sulfuric ester hydrolase activity
EN18_RS07430	COG0123	including yeast histone deacetylase and acetoin utilization protein
EN18_RS07435	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EN18_RS07440	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EN18_RS07460	COG2853	Lipoprotein
EN18_RS07470	COG3088	subunit of a heme lyase
EN18_RS07470	COG4235	cytochrome complex assembly
EN18_RS07475	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EN18_RS07480	COG1138	Cytochrome C-type biogenesis protein
EN18_RS07485	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
EN18_RS07495	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EN18_RS07500	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EN18_RS07505	COG4133	protoheme IX ABC transporter activity
EN18_RS07515	COG0835	chemotaxis
EN18_RS07525	COG1192	Involved in chromosome partitioning
EN18_RS07530	COG2201	protein-glutamate methylesterase activity
EN18_RS07535	COG2198	Histidine kinase
EN18_RS07535	COG0643	Histidine kinase
EN18_RS07535	COG0784	Response regulator, receiver
EN18_RS07540	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
EN18_RS07570	COG2062	phosphohistidine phosphatase, SixA
EN18_RS07575	COG1025	Belongs to the peptidase M16 family
EN18_RS07585	COG0018	arginyl-trna synthetase
EN18_RS07605	COG1918	ferrous iron import across plasma membrane
EN18_RS07610	COG4977	sequence-specific DNA binding
EN18_RS07615	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
EN18_RS07620	COG1121	(ABC) transporter
EN18_RS07625	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EN18_RS07635	COG0045	succinate-CoA ligase (ADP-forming) activity
EN18_RS07640	COG0508	dehydrogenase complex catalyzes the overall conversion of
EN18_RS07645	COG0567	Dehydrogenase, E1 component
EN18_RS07655	COG1053	succinate dehydrogenase
EN18_RS07660	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
EN18_RS07665	COG2009	succinate dehydrogenase
EN18_RS07670	COG0372	Belongs to the citrate synthase family
EN18_RS07675	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EN18_RS07685	COG0033	Phosphoglucomutase
EN18_RS07690	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
EN18_RS07695	COG0596	Alpha beta hydrolase
EN18_RS07710	COG1346	cytolysis
EN18_RS07720	COG0583	DNA-binding transcription factor activity
EN18_RS07730	COG0735	belongs to the Fur family
EN18_RS07735	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EN18_RS07740	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EN18_RS07745	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EN18_RS07755	COG0431	NADPH-dependent FMN reductase
EN18_RS07765	COG3101	peptidyl-lysine hydroxylation
EN18_RS07770	COG2860	membrane
EN18_RS07775	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EN18_RS07785	COG2890	protein-(glutamine-N5) methyltransferase activity
EN18_RS07790	COG2840	Smr protein MutS2
EN18_RS07800	COG1684	flagellar biosynthetic protein fliR
EN18_RS07805	COG1987	bacterial-type flagellum assembly
EN18_RS07830	COG1580	Controls the rotational direction of flagella during chemotaxis
EN18_RS07850	COG1317	bacterial-type flagellum organization
EN18_RS07855	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EN18_RS07865	COG1677	Flagellar hook-basal body complex protein FliE
EN18_RS07885	COG1516	flagellar protein fliS
EN18_RS07895	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
EN18_RS07900	COG1334	flagellar protein FlaG
EN18_RS07905	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EN18_RS07910	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EN18_RS07915	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EN18_RS07920	COG2837	iron assimilation
EN18_RS07940	COG1393	Belongs to the ArsC family
EN18_RS07950	COG1876	peptidase activity
EN18_RS07960	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
EN18_RS07975	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EN18_RS07995	COG4783	chaperone-mediated protein folding
EN18_RS08000	COG1393	Belongs to the ArsC family
EN18_RS08020	COG2233	PERMEase
EN18_RS08025	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EN18_RS08030	COG0737	Belongs to the 5'-nucleotidase family
EN18_RS08035	COG2877	3-deoxy-8-phosphooctulonate synthase activity
EN18_RS08040	COG2912	Transglutaminase-like superfamily
EN18_RS08050	COG2890	protein-(glutamine-N5) methyltransferase activity
EN18_RS08055	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EN18_RS08060	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EN18_RS08065	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
EN18_RS08070	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EN18_RS08075	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EN18_RS08080	COG0193	aminoacyl-tRNA hydrolase activity
EN18_RS08085	COG0012	GTP binding
EN18_RS08170	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EN18_RS08175	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EN18_RS08195	COG3951	Flagellar rod assembly protein muramidase FlgJ
EN18_RS08195	COG1705	Flagellar rod assembly protein muramidase FlgJ
EN18_RS08200	COG1706	bacterial-type flagellum-dependent cell motility
EN18_RS08205	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
EN18_RS08215	COG4787	bacterial-type flagellum-dependent cell motility
EN18_RS08220	COG1749	Flagellar hook protein flgE
EN18_RS08235	COG1815	bacterial-type flagellum-dependent cell motility
EN18_RS08240	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EN18_RS08245	COG0784	Response regulator, receiver
EN18_RS08245	COG0835	chemotaxis
EN18_RS08280	COG2226	methyltransferase
EN18_RS08280	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EN18_RS08280	COG3433	isochorismatase activity
EN18_RS08285	COG2375	cellular response to nickel ion
EN18_RS08290	COG4774	siderophore transport
EN18_RS08290	COG1629	transport
EN18_RS08305	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EN18_RS08310	COG2608	mercury ion transmembrane transporter activity
EN18_RS08310	COG2217	Heavy metal translocating P-type atpase
EN18_RS08325	COG3735	TraB family
EN18_RS08340	COG2840	Smr protein MutS2
EN18_RS08345	COG1187	pseudouridine synthase activity
EN18_RS08355	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
EN18_RS08360	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EN18_RS08365	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EN18_RS08370	COG0121	glutamine amidotransferase
EN18_RS08375	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EN18_RS08380	COG1960	acyl-CoA dehydrogenase activity
EN18_RS08395	COG0328	RNA-DNA hybrid ribonuclease activity
EN18_RS08400	COG2226	methyltransferase
EN18_RS08405	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EN18_RS08410	COG0741	lytic transglycosylase activity
EN18_RS08410	COG1388	LysM domain
EN18_RS08415	COG3021	interspecies interaction between organisms
EN18_RS08420	COG0347	Belongs to the P(II) protein family
EN18_RS08425	COG3479	Phenolic acid decarboxylase
EN18_RS08435	COG0037	tRNA processing
EN18_RS08440	COG0825	malonyl-CoA metabolic process
EN18_RS08445	COG0587	DNA-directed DNA polymerase activity
EN18_RS08450	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EN18_RS08455	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EN18_RS08460	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EN18_RS08465	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EN18_RS08470	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EN18_RS08475	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
EN18_RS08485	COG0750	zinc metalloprotease
EN18_RS08490	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
EN18_RS08495	COG0575	Belongs to the CDS family
EN18_RS08500	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EN18_RS08505	COG0233	cytoplasmic translational termination
EN18_RS08510	COG0528	UMP kinase activity
EN18_RS08515	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EN18_RS08520	COG0052	Belongs to the universal ribosomal protein uS2 family
EN18_RS08525	COG0024	Methionine aminopeptidase
EN18_RS08530	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
EN18_RS08540	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EN18_RS08545	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
EN18_RS08550	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EN18_RS08555	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EN18_RS08570	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EN18_RS08570	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EN18_RS08575	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EN18_RS08580	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EN18_RS08585	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EN18_RS08595	COG1073	alpha beta
EN18_RS08600	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
EN18_RS08605	COG2252	PERMEase
EN18_RS08610	COG2195	Cleaves the N-terminal amino acid of tripeptides
EN18_RS08615	COG4067	protein conserved in archaea
EN18_RS08615	COG0189	ligase activity
EN18_RS08620	COG0189	ligase activity
EN18_RS08630	COG0733	neurotransmitter:sodium symporter activity
EN18_RS08635	COG3706	GGDEF domain
EN18_RS08640	COG3328	transposase activity
EN18_RS08670	COG1477	protein flavinylation
EN18_RS08675	COG2871	sodium ion transport
EN18_RS08680	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EN18_RS08685	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EN18_RS08690	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EN18_RS08695	COG1805	sodium ion transport
EN18_RS08700	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
EN18_RS08705	COG0271	Belongs to the BolA IbaG family
EN18_RS08710	COG2813	Specifically methylates the guanine in position
EN18_RS08720	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EN18_RS08725	COG2211	Major facilitator Superfamily
EN18_RS08735	COG1595	DNA-templated transcription, initiation
EN18_RS08745	COG3248	Nucleoside-binding outer membrane protein
EN18_RS08750	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EN18_RS08755	COG0693	protein deglycase activity
EN18_RS08760	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EN18_RS08765	COG2166	iron-sulfur cluster assembly
EN18_RS08770	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EN18_RS08775	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
EN18_RS08785	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
EN18_RS08785	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EN18_RS08800	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EN18_RS08805	COG1074	ATP-dependent DNA helicase activity
EN18_RS08810	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
EN18_RS08825	COG3141	response to X-ray
EN18_RS08830	COG2171	N-acyltransferase activity
EN18_RS08840	COG0456	acetyltransferase
EN18_RS08845	COG0189	ligase activity
EN18_RS08845	COG0569	domain protein
EN18_RS08860	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EN18_RS08865	COG1609	Transcriptional regulator
EN18_RS08870	COG3250	beta-galactosidase activity
EN18_RS08885	COG1022	Amp-dependent synthetase and ligase
EN18_RS08890	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EN18_RS08895	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EN18_RS08905	COG0560	Phosphoserine phosphatase
EN18_RS08915	COG0813	purine-nucleoside phosphorylase activity
EN18_RS08920	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
EN18_RS08925	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
EN18_RS08930	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EN18_RS08940	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EN18_RS08945	COG0084	hydrolase, TatD family'
EN18_RS08950	COG3022	response to hydroperoxide
EN18_RS08955	COG1115	amino acid carrier protein
EN18_RS08970	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EN18_RS08975	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
EN18_RS08980	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
EN18_RS08985	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
EN18_RS09005	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EN18_RS09015	COG0745	RESPONSE REGULATOR receiver
EN18_RS09020	COG5002	protein histidine kinase activity
EN18_RS09020	COG2198	Histidine kinase
EN18_RS09020	COG0784	Response regulator, receiver
EN18_RS09025	COG3706	GGDEF domain
EN18_RS09025	COG2203	Gaf domain
EN18_RS09025	COG5001	Diguanylate cyclase
EN18_RS09025	COG4251	negative regulation of phosphorylation
EN18_RS09030	COG1242	4 iron, 4 sulfur cluster binding
EN18_RS09035	COG0067	glutamate synthase
EN18_RS09035	COG0070	glutamate synthase
EN18_RS09035	COG0069	glutamate synthase activity
EN18_RS09045	COG0067	glutamate synthase
EN18_RS09045	COG0069	glutamate synthase activity
EN18_RS09045	COG0070	glutamate synthase
EN18_RS09050	COG0493	'glutamate synthase
EN18_RS09060	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EN18_RS09070	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EN18_RS09075	COG2860	membrane
EN18_RS09080	COG0583	DNA-binding transcription factor activity
EN18_RS09085	COG0730	response to heat
EN18_RS09095	COG4172	Belongs to the ABC transporter superfamily
EN18_RS09115	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EN18_RS09120	COG0505	Belongs to the CarA family
EN18_RS09130	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EN18_RS09135	COG0494	nUDIX hydrolase
EN18_RS09145	COG0653	protein targeting
EN18_RS09155	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
EN18_RS09160	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EN18_RS09165	COG0849	cell division
EN18_RS09170	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EN18_RS09175	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EN18_RS09185	COG0772	Belongs to the SEDS family
EN18_RS09190	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EN18_RS09200	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EN18_RS09205	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EN18_RS09210	COG0768	penicillin binding
EN18_RS09215	COG3116	cell division
EN18_RS09225	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EN18_RS09230	COG0508	dehydrogenase complex catalyzes the overall conversion of
EN18_RS09235	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
EN18_RS09240	COG2186	Transcriptional regulator
EN18_RS09245	COG0737	Belongs to the 5'-nucleotidase family
EN18_RS09250	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EN18_RS09255	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EN18_RS09260	COG4974	Belongs to the 'phage' integrase family
EN18_RS09265	COG0716	FMN binding
EN18_RS09285	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EN18_RS09290	COG1459	type II secretion system
EN18_RS09300	COG0237	dephospho-CoA kinase activity
EN18_RS09305	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
EN18_RS09315	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EN18_RS09320	COG0187	DNA topoisomerase II activity
EN18_RS09325	COG3150	esterase
EN18_RS09335	COG3151	Protein conserved in bacteria
EN18_RS09340	COG0494	nUDIX hydrolase
EN18_RS09345	COG1538	Outer membrane efflux protein
EN18_RS09355	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
EN18_RS09360	COG0840	transmembrane signaling receptor activity
EN18_RS09365	COG3025	triphosphatase activity
EN18_RS09370	COG1392	Phosphate transport regulator
EN18_RS09375	COG0306	phosphate transporter
EN18_RS09380	COG4991	sh3 domain protein
EN18_RS09390	COG3409	Peptidoglycan-binding domain 1 protein
EN18_RS09390	COG3267	Type II secretory pathway component ExeA
EN18_RS09400	COG0148	phosphopyruvate hydratase activity
EN18_RS09405	COG0504	CTP synthase activity
EN18_RS09410	COG3956	TIGRFAM MazG family protein
EN18_RS09415	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EN18_RS09430	COG5001	Diguanylate cyclase
EN18_RS09450	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
EN18_RS09455	COG1381	Involved in DNA repair and RecF pathway recombination
EN18_RS09460	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EN18_RS09475	COG0481	GTPase activity
EN18_RS09480	COG3086	response to oxidative stress
EN18_RS09495	COG1595	DNA-templated transcription, initiation
EN18_RS09505	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EN18_RS09515	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
EN18_RS09530	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EN18_RS09535	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EN18_RS09540	COG3079	Belongs to the UPF0149 family
EN18_RS09545	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
EN18_RS09550	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EN18_RS09555	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EN18_RS09560	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EN18_RS09565	COG0440	acetolactate synthase activity
EN18_RS09570	COG0028	Belongs to the TPP enzyme family
EN18_RS09575	COG1022	Amp-dependent synthetase and ligase
EN18_RS09580	COG0583	DNA-binding transcription factor activity
EN18_RS09605	COG0473	3-isopropylmalate dehydrogenase activity
EN18_RS09610	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EN18_RS09615	COG0066	3-isopropylmalate dehydratase activity
EN18_RS09660	COG3437	response regulator, receiver
EN18_RS09675	COG0795	lipopolysaccharide-transporting ATPase activity
EN18_RS09680	COG0795	lipopolysaccharide-transporting ATPase activity
EN18_RS09685	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EN18_RS09690	COG2927	DNA polymerase III (CHI subunit)
EN18_RS09695	COG0525	valine-tRNA ligase activity
EN18_RS09700	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EN18_RS09705	COG0564	pseudouridine synthase activity
EN18_RS09720	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
EN18_RS09735	COG0540	Belongs to the ATCase OTCase family
EN18_RS09745	COG0251	oxidation-reduction process
EN18_RS09755	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EN18_RS09760	COG5007	Belongs to the BolA IbaG family
EN18_RS09770	COG2854	intermembrane phospholipid transfer
EN18_RS09775	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EN18_RS09780	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EN18_RS09785	COG1127	ABC transporter
EN18_RS09800	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
EN18_RS09800	COG0517	IMP dehydrogenase activity
EN18_RS09815	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
EN18_RS09820	COG1137	ATPase activity
EN18_RS09830	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EN18_RS09835	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EN18_RS09840	COG1660	Displays ATPase and GTPase activities
EN18_RS09845	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EN18_RS09850	COG2239	Acts as a magnesium transporter
EN18_RS09855	COG0312	modulator of DNA gyrase
EN18_RS09860	COG3028	Belongs to the UPF0307 family
EN18_RS09865	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
EN18_RS09870	COG1178	ABC-type Fe3 transport system permease component
EN18_RS09880	COG0163	prenyltransferase activity
EN18_RS09885	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EN18_RS09900	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
EN18_RS09905	COG2105	PFAM AIG2 family protein
EN18_RS09915	COG0729	surface antigen
EN18_RS09920	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EN18_RS09925	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
EN18_RS09940	COG1136	(ABC) transporter
EN18_RS09960	COG0529	Catalyzes the synthesis of activated sulfate
EN18_RS09975	COG1648	precorrin-2 dehydrogenase activity
EN18_RS09975	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EN18_RS09980	COG0737	Belongs to the 5'-nucleotidase family
EN18_RS09990	COG0513	Belongs to the DEAD box helicase family
EN18_RS09995	COG2153	protein acetylation
EN18_RS10000	COG0697	spore germination
EN18_RS10005	COG3061	Opacity-associated protein A
EN18_RS10005	COG3266	domain, Protein
EN18_RS10010	COG0545	Peptidyl-prolyl cis-trans isomerase
EN18_RS10020	COG0203	ribosomal protein L17
EN18_RS10025	COG0202	RNA polymerase activity
EN18_RS10030	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EN18_RS10035	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EN18_RS10040	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EN18_RS10045	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EN18_RS10050	COG0201	protein transport
EN18_RS10060	COG1841	ribosomal large subunit assembly
EN18_RS10065	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
EN18_RS10070	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EN18_RS10080	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EN18_RS10085	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EN18_RS10090	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EN18_RS10095	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EN18_RS10100	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EN18_RS10105	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EN18_RS10110	COG0255	Belongs to the universal ribosomal protein uL29 family
EN18_RS10115	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EN18_RS10120	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EN18_RS10125	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EN18_RS10130	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EN18_RS10135	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EN18_RS10140	COG0089	rRNA binding
EN18_RS10145	COG0088	Forms part of the polypeptide exit tunnel
EN18_RS10150	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EN18_RS10155	COG0051	transcription antitermination factor activity, RNA binding
EN18_RS10160	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EN18_RS10165	COG0557	exoribonuclease II activity
EN18_RS10170	COG3083	sulfuric ester hydrolase activity
EN18_RS10175	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
EN18_RS10190	COG1047	Peptidyl-prolyl cis-trans
EN18_RS10205	COG2249	NAD(P)H dehydrogenase (quinone) activity
EN18_RS10210	COG0488	(ABC) transporter
EN18_RS10220	COG0429	hydrolase of the alpha beta-hydrolase fold
EN18_RS10230	COG3954	Phosphoribulokinase
EN18_RS10245	COG1012	belongs to the aldehyde dehydrogenase family
EN18_RS10255	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EN18_RS10265	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EN18_RS10280	COG0180	Tryptophanyl-tRNA synthetase
EN18_RS10285	COG0546	phosphoglycolate phosphatase activity
EN18_RS10290	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EN18_RS10295	COG0338	D12 class N6 adenine-specific DNA methyltransferase
EN18_RS10305	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EN18_RS10310	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EN18_RS10340	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EN18_RS10350	COG0678	peroxiredoxin activity
EN18_RS10350	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EN18_RS10355	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EN18_RS10365	COG0165	Argininosuccinate lyase
EN18_RS10370	COG0137	argininosuccinate synthase activity
EN18_RS10375	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EN18_RS10380	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EN18_RS10385	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EN18_RS10390	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
EN18_RS10400	COG1045	serine acetyltransferase
EN18_RS10405	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EN18_RS10410	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
EN18_RS10415	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EN18_RS10420	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
EN18_RS10425	COG1053	succinate dehydrogenase
EN18_RS10430	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EN18_RS10435	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
EN18_RS10445	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EN18_RS10450	COG1509	lysine 2,3-aminomutase activity
EN18_RS10460	COG0459	protein refolding
EN18_RS10465	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EN18_RS10490	COG0149	triose-phosphate isomerase activity
EN18_RS10495	COG0534	Mate efflux family protein
EN18_RS10500	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EN18_RS10505	COG1575	Belongs to the MenA family. Type 1 subfamily
EN18_RS10510	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
EN18_RS10515	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EN18_RS10520	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EN18_RS10525	COG1609	Transcriptional regulator
EN18_RS10530	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EN18_RS10535	COG0254	rRNA binding
EN18_RS10540	COG0281	malic enzyme
EN18_RS10545	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
EN18_RS10550	COG0626	cystathionine gamma-synthase activity
EN18_RS10555	COG0527	aspartate kinase activity
EN18_RS10555	COG0460	homoserine dehydrogenase
EN18_RS10560	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EN18_RS10565	COG3074	FtsZ-dependent cytokinesis
EN18_RS10570	COG1494	fructose-1,6-bisphosphatase
EN18_RS10575	COG0205	6-phosphofructokinase activity
EN18_RS10580	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EN18_RS10590	COG0745	RESPONSE REGULATOR receiver
EN18_RS10595	COG2205	protein histidine kinase activity
EN18_RS10605	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EN18_RS10610	COG3030	protein affecting phage T7 exclusion by the F plasmid
EN18_RS10615	COG3706	GGDEF domain
EN18_RS10620	COG1027	Aspartate ammonia-lyase
EN18_RS10625	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EN18_RS10640	COG4232	protein-disulfide reductase activity
EN18_RS10660	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EN18_RS10665	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
EN18_RS10670	COG0194	GDP metabolic process
EN18_RS10675	COG1758	RNA polymerase activity
EN18_RS10680	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EN18_RS10685	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EN18_RS10690	COG2233	PERMEase
EN18_RS10705	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EN18_RS10710	COG2183	response to ionizing radiation
EN18_RS10720	COG0596	Alpha beta hydrolase
EN18_RS10725	COG1040	competence protein
EN18_RS10735	COG0494	nUDIX hydrolase
EN18_RS10740	COG1218	3'(2'),5'-bisphosphate nucleotidase
EN18_RS10750	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
EN18_RS10755	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
EN18_RS10760	COG3156	type II secretion system protein K
EN18_RS10765	COG4795	General secretion pathway protein
EN18_RS10770	COG2165	general secretion pathway protein
EN18_RS10775	COG2165	general secretion pathway protein
EN18_RS10780	COG2165	general secretion pathway protein
EN18_RS10785	COG1459	type II secretion system
EN18_RS10790	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EN18_RS10800	COG3031	protein transport across the cell outer membrane
EN18_RS10805	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EN18_RS10810	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EN18_RS10815	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
EN18_RS10825	COG0456	acetyltransferase
EN18_RS10830	COG1490	D-aminoacyl-tRNA deacylase activity
EN18_RS10835	COG1295	ribonuclease BN
EN18_RS10845	COG1217	gtp-binding protein TYPA
EN18_RS10855	COG0174	glutamine synthetase
EN18_RS10865	COG3852	Histidine kinase
EN18_RS10875	COG5001	Diguanylate cyclase
EN18_RS10875	COG3300	MHYT domain
EN18_RS10880	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EN18_RS10915	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EN18_RS10920	COG1404	Belongs to the peptidase S8 family
EN18_RS10925	COG4206	TonB-dependent receptor
EN18_RS10930	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EN18_RS10945	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EN18_RS10950	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EN18_RS10955	COG2177	Part of the ABC transporter FtsEX involved in
EN18_RS10960	COG2884	Cell division ATP-binding protein ftsE
EN18_RS10965	COG0552	protein localization to endoplasmic reticulum
EN18_RS10970	COG0742	ribosomal rna small subunit methyltransferase
EN18_RS11005	COG0783	Belongs to the Dps family
EN18_RS11010	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
EN18_RS11015	COG1280	lysine exporter protein (LysE YggA)
EN18_RS11020	COG2267	carboxylic ester hydrolase activity
EN18_RS11025	COG0561	phosphatase activity
EN18_RS11045	COG2199	diguanylate cyclase activity
EN18_RS11045	COG2200	EAL domain
EN18_RS11045	COG3287	FIST C domain
EN18_RS11050	COG1011	Hydrolase
EN18_RS11055	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
EN18_RS11065	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EN18_RS11070	COG0019	diaminopimelate decarboxylase activity
EN18_RS11080	COG1965	Belongs to the frataxin family
EN18_RS11095	COG0181	hydroxymethylbilane synthase activity
EN18_RS11100	COG1587	Uroporphyrinogen-III synthase
EN18_RS11105	COG2959	enzyme of heme biosynthesis
EN18_RS11110	COG3071	HemY protein
EN18_RS11125	COG3078	GTPase activator activity
EN18_RS11145	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EN18_RS11145	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EN18_RS11160	COG0084	hydrolase, TatD family'
EN18_RS11170	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EN18_RS11180	COG0840	transmembrane signaling receptor activity
EN18_RS11185	COG1580	Controls the rotational direction of flagella during chemotaxis
EN18_RS11195	COG3161	chorismate lyase activity
EN18_RS11200	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EN18_RS11210	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EN18_RS11220	COG0534	Mate efflux family protein
EN18_RS11225	COG1858	cytochrome C peroxidase
EN18_RS11230	COG0805	protein transport
EN18_RS11235	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EN18_RS11240	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EN18_RS11255	COG2226	methyltransferase
EN18_RS11260	COG1322	Protein conserved in bacteria
EN18_RS11270	COG2081	HI0933 family
EN18_RS11280	COG1528	Iron-storage protein
EN18_RS11290	COG0589	response to stress
EN18_RS11310	COG5002	protein histidine kinase activity
EN18_RS11310	COG5001	Diguanylate cyclase
EN18_RS11315	COG1522	sequence-specific DNA binding
EN18_RS11335	COG0006	proline dipeptidase activity
EN18_RS11335	COG0006	proline dipeptidase activity
EN18_RS11340	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EN18_RS11345	COG2022	thiamine diphosphate biosynthetic process
EN18_RS11350	COG2104	thiamine diphosphate biosynthetic process
EN18_RS11355	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EN18_RS11365	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
EN18_RS11370	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EN18_RS11410	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EN18_RS11420	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EN18_RS11425	COG0408	coproporphyrinogen oxidase activity
EN18_RS11430	COG0009	L-threonylcarbamoyladenylate synthase
EN18_RS11435	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EN18_RS11440	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EN18_RS11445	COG0551	DNA topoisomerase type I activity
EN18_RS11450	COG2922	Belongs to the Smg family
EN18_RS11455	COG0758	DNA mediated transformation
EN18_RS11460	COG1652	LysM domain
EN18_RS11465	COG0242	peptide deformylase activity
EN18_RS11470	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EN18_RS11475	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EN18_RS11475	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EN18_RS11480	COG0569	domain protein
EN18_RS11485	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EN18_RS11495	COG1272	protein, Hemolysin III
EN18_RS11500	COG4326	sporulation control protein
EN18_RS11510	COG3084	Protein conserved in bacteria
EN18_RS11520	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EN18_RS11525	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EN18_RS11530	COG0204	Acyl-transferase
EN18_RS11535	COG0606	chelatase, subunit chli
EN18_RS11550	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EN18_RS11555	COG0129	dihydroxy-acid dehydratase activity
EN18_RS11565	COG0604	alcohol dehydrogenase
EN18_RS11575	COG0425	Belongs to the sulfur carrier protein TusA family
EN18_RS11585	COG2119	membrane
EN18_RS11590	COG0752	glycyl-tRNA synthetase alpha subunit
EN18_RS11595	COG0751	glycine-tRNA ligase activity
EN18_RS11600	COG3977	Valine--pyruvate aminotransferase
EN18_RS11605	COG0071	Belongs to the small heat shock protein (HSP20) family
EN18_RS11620	COG0187	DNA topoisomerase II activity
EN18_RS11625	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EN18_RS11630	COG0592	DNA-directed DNA polymerase activity
EN18_RS11635	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EN18_RS11650	COG1126	abc transporter atp-binding protein
EN18_RS11655	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EN18_RS11660	COG0594	ribonuclease P activity
EN18_RS11670	COG0706	membrane insertase activity
EN18_RS11675	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EN18_RS11680	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EN18_RS11690	COG0445	tRNA wobble uridine modification
EN18_RS11700	COG1192	Involved in chromosome partitioning
EN18_RS11705	COG1475	DNA binding
EN18_RS11710	COG3312	ion transport
EN18_RS11715	COG0356	it plays a direct role in the translocation of protons across the membrane
EN18_RS11725	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EN18_RS11730	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EN18_RS11735	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EN18_RS11740	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EN18_RS11745	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EN18_RS11750	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EN18_RS11755	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EN18_RS11760	COG2814	Major facilitator Superfamily
EN18_RS11765	COG0583	DNA-binding transcription factor activity
EN18_RS11770	COG0183	Belongs to the thiolase family
EN18_RS11780	COG1739	Uncharacterized protein family UPF0029
EN18_RS11785	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EN18_RS11790	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
EN18_RS11835	COG0583	DNA-binding transcription factor activity
EN18_RS11840	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EN18_RS11845	COG2960	long-chain fatty acid transporting porin activity
EN18_RS11850	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EN18_RS11855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EN18_RS11860	COG1309	transcriptional regulator
EN18_RS11915	COG0747	negative chemotaxis
EN18_RS11920	COG0601	transmembrane transport
EN18_RS11925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EN18_RS11935	COG2131	deaminase
EN18_RS11960	COG3621	Patatin-like phospholipase
EN18_RS12000	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EN18_RS12005	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
EN18_RS12015	COG0210	DNA helicase
EN18_RS12020	COG1280	lysine exporter protein (LysE YggA)
EN18_RS12035	COG2962	Rard protein
EN18_RS12040	COG0514	ATP-dependent DNA helicase (RecQ)
EN18_RS12055	COG1132	(ABC) transporter
EN18_RS12060	COG4774	siderophore transport
EN18_RS12065	COG1120	ATPase activity
EN18_RS12090	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EN18_RS12095	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EN18_RS12095	COG1263	PTS System
EN18_RS12100	COG2862	Uncharacterized protein family, UPF0114
EN18_RS12105	COG1561	YicC-like family, N-terminal region
EN18_RS12110	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EN18_RS12115	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EN18_RS12120	COG1560	Kdo2-lipid A biosynthetic process
EN18_RS12125	COG1560	Kdo2-lipid A biosynthetic process
EN18_RS12130	COG1309	transcriptional regulator
EN18_RS12135	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EN18_RS12145	COG2003	Belongs to the UPF0758 family
EN18_RS12150	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EN18_RS12155	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EN18_RS12165	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EN18_RS12170	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EN18_RS12175	COG0859	PFAM glycosyl transferase family 9
EN18_RS12180	COG0463	Glycosyl transferase, family 2
EN18_RS12185	COG0859	PFAM glycosyl transferase family 9
EN18_RS12190	COG3642	lipopolysaccharide core region biosynthetic process
EN18_RS12220	COG1519	Transferase
EN18_RS12255	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EN18_RS12260	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
EN18_RS12260	COG0662	Cupin 2, conserved barrel domain protein
EN18_RS12265	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EN18_RS12270	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
EN18_RS12300	COG0318	PFAM AMP-dependent synthetase and ligase
EN18_RS12305	COG1012	belongs to the aldehyde dehydrogenase family
EN18_RS12305	COG1454	alcohol dehydrogenase
EN18_RS12320	COG5433	transposase activity
EN18_RS12350	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EN18_RS12355	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
EN18_RS12360	COG0668	transmembrane transport
EN18_RS12365	COG1573	uracil-dna glycosylase
EN18_RS12375	COG3068	Protein conserved in bacteria
EN18_RS12385	COG1940	carbohydrate kinase activity
EN18_RS12390	COG1253	flavin adenine dinucleotide binding
EN18_RS12400	COG0776	regulation of translation
EN18_RS12410	COG0151	Belongs to the GarS family
EN18_RS12420	COG0789	Transcriptional regulator
EN18_RS12425	COG3710	Transcriptional regulator
EN18_RS12430	COG0531	amino acid
EN18_RS12435	COG1982	Orn Lys Arg decarboxylase major
EN18_RS12440	COG0840	transmembrane signaling receptor activity
EN18_RS12460	COG0800	Aldolase
EN18_RS12470	COG3265	gluconokinase activity
EN18_RS12475	COG0129	dihydroxy-acid dehydratase activity
EN18_RS12480	COG1609	Transcriptional regulator
EN18_RS12485	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
EN18_RS12490	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EN18_RS12495	COG2264	protein methyltransferase activity
EN18_RS12500	COG0439	Biotin carboxylase
EN18_RS12505	COG0511	ligase activity, forming carbon-carbon bonds
EN18_RS12510	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EN18_RS12515	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EN18_RS12535	COG2814	Major facilitator Superfamily
EN18_RS12540	COG2205	protein histidine kinase activity
EN18_RS12540	COG0784	Response regulator, receiver
EN18_RS12545	COG0248	Ppx GppA phosphatase
EN18_RS12550	COG0513	Belongs to the DEAD box helicase family
EN18_RS12555	COG3118	belongs to the thioredoxin family
EN18_RS12570	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
EN18_RS12615	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EN18_RS12630	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EN18_RS12640	COG1072	(Pantothenic acid kinase))
EN18_RS12665	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EN18_RS12670	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EN18_RS12675	COG0250	Participates in transcription elongation, termination and antitermination
EN18_RS12680	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EN18_RS12690	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EN18_RS12695	COG0222	ribosome binding
EN18_RS12700	COG0085	RNA polymerase activity
EN18_RS12705	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EN18_RS12710	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
EN18_RS12715	COG2816	NAD+ diphosphatase activity
EN18_RS12720	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EN18_RS12735	COG4942	peptidase
EN18_RS12740	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
EN18_RS12750	COG0471	metal ion transport
EN18_RS12755	COG0688	phosphatidylethanolamine metabolic process
EN18_RS12760	COG1162	GTPase activity
EN18_RS12765	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
EN18_RS12810	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EN18_RS12815	COG0802	atpase or kinase
EN18_RS12825	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EN18_RS12830	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EN18_RS12835	COG1923	regulation of RNA biosynthetic process
EN18_RS12840	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EN18_RS12845	COG0330	HflC and HflK could
EN18_RS12850	COG0330	HflC and HflK could
EN18_RS12855	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
EN18_RS12860	COG2900	Belongs to the SlyX family
EN18_RS12870	COG0545	Peptidyl-prolyl cis-trans isomerase
EN18_RS12875	COG2964	Protein conserved in bacteria
EN18_RS12880	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
EN18_RS12885	COG2923	Belongs to the DsrF TusC family
EN18_RS12900	COG0049	tRNA binding
EN18_RS12905	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EN18_RS12910	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EN18_RS12915	COG2906	2 iron, 2 sulfur cluster binding
EN18_RS12925	COG0360	Binds together with S18 to 16S ribosomal RNA
EN18_RS12930	COG2965	DNA replication, synthesis of RNA primer
EN18_RS12935	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
EN18_RS12940	COG0359	binds to the 23S rRNA
EN18_RS12955	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EN18_RS12960	COG0432	Pfam Uncharacterised protein family UPF0047
EN18_RS12980	COG0735	belongs to the Fur family
EN18_RS12985	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EN18_RS13010	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EN18_RS13020	COG0175	sulfate reduction
EN18_RS13115	COG1410	methionine synthase
EN18_RS13115	COG0646	methionine synthase
EN18_RS13120	COG0527	aspartate kinase activity
EN18_RS13125	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EN18_RS13135	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EN18_RS13150	COG0629	single-stranded DNA binding
EN18_RS13155	COG2199	diguanylate cyclase activity
EN18_RS13155	COG2200	EAL domain
EN18_RS13180	COG3267	Type II secretory pathway component ExeA
EN18_RS13180	COG3409	Peptidoglycan-binding domain 1 protein
EN18_RS13190	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EN18_RS13195	COG1459	type II secretion system
EN18_RS13205	COG2165	general secretion pathway protein
EN18_RS13210	COG2165	general secretion pathway protein
EN18_RS13240	COG1077	Cell shape determining protein MreB Mrl
EN18_RS13245	COG1792	Involved in formation and maintenance of cell shape
EN18_RS13250	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
EN18_RS13255	COG0424	maF-like protein
EN18_RS13265	COG3164	Protein of unknown function
EN18_RS13270	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EN18_RS13275	COG0312	modulator of DNA gyrase
EN18_RS13280	COG2235	arginine
EN18_RS13300	COG0589	response to stress
EN18_RS13310	COG2358	TRAP transporter, solute receptor (TAXI family
EN18_RS13315	COG1438	arginine binding
EN18_RS13320	COG0039	L-malate dehydrogenase activity
EN18_RS13325	COG0531	amino acid
EN18_RS13330	COG0531	amino acid
EN18_RS13335	COG0142	geranyltranstransferase activity
EN18_RS13340	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EN18_RS13345	COG0211	Belongs to the bacterial ribosomal protein bL27 family
EN18_RS13350	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EN18_RS13355	COG2966	Psort location CytoplasmicMembrane, score
EN18_RS13360	COG3610	response to peptide
EN18_RS13370	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EN18_RS13375	COG2967	ApaG domain
EN18_RS13380	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EN18_RS13385	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EN18_RS13390	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EN18_RS13395	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
EN18_RS13400	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
EN18_RS13455	COG0741	lytic transglycosylase activity
EN18_RS13460	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
EN18_RS13465	COG1194	a g-specific adenine glycosylase
EN18_RS13475	COG2066	Belongs to the glutaminase family
EN18_RS13480	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EN18_RS13485	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EN18_RS13495	COG1872	DUF167
EN18_RS13500	COG0762	integral membrane protein
EN18_RS13505	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EN18_RS13510	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EN18_RS13530	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EN18_RS13535	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EN18_RS13540	COG1678	Uncharacterized ACR, COG1678
EN18_RS13545	COG0189	ligase activity
EN18_RS13550	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EN18_RS13555	COG2356	endonuclease I
EN18_RS13565	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EN18_RS13575	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EN18_RS13580	COG0583	DNA-binding transcription factor activity
EN18_RS13585	COG4771	TonB-dependent receptor
EN18_RS13590	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EN18_RS13595	COG0126	phosphoglycerate kinase activity
EN18_RS13600	COG0191	fructose-bisphosphate aldolase activity
EN18_RS13610	COG0668	transmembrane transport
EN18_RS13615	COG1279	arginine transmembrane transporter activity
EN18_RS13635	COG1349	DNA-binding transcription factor activity
EN18_RS13640	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EN18_RS13645	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EN18_RS13690	COG2207	Transcriptional regulator
EN18_RS13700	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
EN18_RS13705	COG0582	viral genome integration into host DNA
EN18_RS13720	COG0358	DNA primase activity
EN18_RS13725	COG1610	YqeY-like protein
EN18_RS13730	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EN18_RS13735	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EN18_RS13745	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EN18_RS13750	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EN18_RS13755	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EN18_RS13760	COG1968	undecaprenyl-diphosphatase activity
EN18_RS13765	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
EN18_RS13770	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EN18_RS13775	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
EN18_RS13780	COG0585	pseudouridine synthase activity
EN18_RS13785	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
EN18_RS13790	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EN18_RS13800	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EN18_RS13805	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EN18_RS13825	COG4208	sulfate ABC transporter
EN18_RS13830	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
EN18_RS13840	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EN18_RS13850	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EN18_RS13855	COG0527	aspartate kinase activity
EN18_RS13860	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
EN18_RS13915	COG3630	sodium ion export across plasma membrane
EN18_RS13920	COG0511	ligase activity, forming carbon-carbon bonds
EN18_RS13920	COG5016	pyruvate
EN18_RS13925	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
EN18_RS13935	COG1238	metal cluster binding
EN18_RS13940	COG0612	Peptidase, M16
EN18_RS13945	COG2918	glutathione biosynthetic process
EN18_RS13950	COG1854	S-ribosylhomocysteine lyase activity
EN18_RS13955	COG4536	flavin adenine dinucleotide binding
EN18_RS13960	COG4137	Cytochrome C assembly protein
EN18_RS13965	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EN18_RS13970	COG0228	four-way junction DNA binding
EN18_RS13975	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EN18_RS13980	COG0336	Belongs to the RNA methyltransferase TrmD family
EN18_RS13985	COG0335	large ribosomal subunit rRNA binding
EN18_RS13990	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EN18_RS13995	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EN18_RS14005	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
EN18_RS14015	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EN18_RS14020	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EN18_RS14025	COG0723	plastoquinol--plastocyanin reductase activity
EN18_RS14030	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EN18_RS14035	COG2857	Cytochrome c1
EN18_RS14040	COG0625	glutathione transferase activity
EN18_RS14045	COG2969	positive regulation of protein catabolic process
EN18_RS14050	COG2823	Periplasmic or secreted lipoprotein
EN18_RS14055	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EN18_RS14060	COG0792	nuclease activity
EN18_RS14065	COG3107	peptidoglycan biosynthetic process
EN18_RS14070	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EN18_RS14085	COG0288	reversible hydration of carbon dioxide
EN18_RS14090	COG0659	secondary active sulfate transmembrane transporter activity
EN18_RS14095	COG1131	(ABC) transporter
EN18_RS14100	COG0842	Transport permease protein
EN18_RS14105	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EN18_RS14200	COG0004	ammonium transporteR
EN18_RS14440	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
EN18_RS14485	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EN18_RS14515	COG0195	Participates in both transcription termination and antitermination
EN18_RS14535	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EN18_RS14550	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EN18_RS14620	COG0826	peptidase U32
EN18_RS15320	COG0728	peptidoglycan biosynthetic process
EN18_RS15440	COG5001	Diguanylate cyclase
EN18_RS15525	COG0826	peptidase U32
EN18_RS15755	COG1160	GTP binding
EN18_RS16125	COG3064	Membrane
EN18_RS17080	COG0183	Belongs to the thiolase family
EN18_RS17085	COG1250	3-hydroxyacyl-CoA dehydrogenase
EN18_RS17085	COG1024	Enoyl-CoA hydratase
EN18_RS17435	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EN18_RS17470	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EN18_RS17550	COG3273	potassium ion transport
EN18_RS17550	COG2985	domain, Protein
EN18_RS17745	COG0281	malic enzyme
EN18_RS17855	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EN18_RS17905	COG0072	phenylalanine-tRNA ligase activity
EN18_RS17905	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EN18_RS18150	COG2943	transferase activity, transferring hexosyl groups
EN18_RS18430	COG2828	Protein conserved in bacteria
EN18_RS18710	COG2201	protein-glutamate methylesterase activity
EN18_RS18805	COG3501	Rhs element vgr protein
EN18_RS18960	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
EN18_RS18960	COG3064	Membrane
EN18_RS18960	COG1073	alpha beta
EN18_RS18985	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
EN18_RS18985	COG3064	Membrane
EN18_RS18985	COG1073	alpha beta
EN18_RS18990	COG3064	Membrane
EN18_RS18990	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
EN18_RS18990	COG1073	alpha beta
EN18_RS19015	COG3064	Membrane
EN18_RS19015	COG1073	alpha beta
EN18_RS19015	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
EN18_RS19040	COG4128	Pfam Zonular occludens toxin
EN18_RS19180	COG0004	ammonium transporteR
EN18_RS19295	COG4608	Belongs to the ABC transporter superfamily
EN18_RS19430	COG0739	heme binding
EN18_RS19505	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate