locus-tag	class	description
GPW74_RS00010	COG3051	citrate lyase alpha subunit
GPW74_RS00015	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
GPW74_RS00020	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
GPW74_RS00030	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPW74_RS00035	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GPW74_RS00040	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
GPW74_RS00055	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GPW74_RS00060	COG0732	type I restriction modification DNA specificity domain
GPW74_RS00065	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GPW74_RS00090	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GPW74_RS00095	COG2867	negative regulation of translational initiation
GPW74_RS00100	COG2914	Belongs to the UPF0125 (RnfH) family
GPW74_RS00105	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPW74_RS00110	COG0497	DNA recombination
GPW74_RS00115	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GPW74_RS00120	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GPW74_RS00125	COG0443	Heat shock 70 kDa protein
GPW74_RS00130	COG0484	heat shock protein binding
GPW74_RS00165	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPW74_RS00170	COG0590	tRNA wobble adenosine to inosine editing
GPW74_RS00175	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
GPW74_RS00180	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GPW74_RS00180	COG0047	phosphoribosylformylglycinamidine synthase activity
GPW74_RS00200	COG0442	prolyl-tRNA aminoacylation
GPW74_RS00205	COG1720	tRNA m6t6A37 methyltransferase activity
GPW74_RS00210	COG0254	rRNA binding
GPW74_RS00215	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GPW74_RS00220	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
GPW74_RS00225	COG1671	Belongs to the UPF0178 family
GPW74_RS00235	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPW74_RS00250	COG3098	single-species biofilm formation
GPW74_RS00255	COG0564	pseudouridine synthase activity
GPW74_RS00260	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GPW74_RS00265	COG0142	geranyltranstransferase activity
GPW74_RS00270	COG1722	exodeoxyribonuclease VII activity
GPW74_RS00275	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GPW74_RS00285	COG0301	tRNA thio-modification
GPW74_RS00285	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPW74_RS00290	COG0583	DNA-binding transcription factor activity
GPW74_RS00295	COG2363	Small membrane protein
GPW74_RS00300	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPW74_RS00305	COG1611	Belongs to the LOG family
GPW74_RS00310	COG3706	GGDEF domain
GPW74_RS00320	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GPW74_RS00320	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GPW74_RS00330	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
GPW74_RS00335	COG1464	Belongs to the NlpA lipoprotein family
GPW74_RS00340	COG2011	ABC-type metal ion transport system permease component
GPW74_RS00345	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GPW74_RS00350	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GPW74_RS00355	COG1609	Transcriptional regulator
GPW74_RS00360	COG1263	PTS System
GPW74_RS00360	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPW74_RS00365	COG0366	Alpha amylase catalytic
GPW74_RS00395	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPW74_RS00400	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GPW74_RS00405	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GPW74_RS00410	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GPW74_RS00435	COG1045	serine acetyltransferase
GPW74_RS00445	COG0438	transferase activity, transferring glycosyl groups
GPW74_RS00455	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
GPW74_RS00485	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GPW74_RS00495	COG1596	polysaccharide export
GPW74_RS00520	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GPW74_RS00530	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GPW74_RS00535	COG0321	lipoyl(octanoyl) transferase activity
GPW74_RS00540	COG2921	Belongs to the UPF0250 family
GPW74_RS00545	COG1686	Belongs to the peptidase S11 family
GPW74_RS00555	COG0772	Belongs to the SEDS family
GPW74_RS00560	COG0768	penicillin binding
GPW74_RS00565	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GPW74_RS00570	COG0799	negative regulation of ribosome biogenesis
GPW74_RS00575	COG1466	dna polymerase III delta subunit
GPW74_RS00580	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
GPW74_RS00585	COG0495	leucyl-tRNA aminoacylation
GPW74_RS00590	COG2888	peptidyl-tyrosine sulfation
GPW74_RS00595	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GPW74_RS00600	COG4535	Mg2 and Co2 transporter CorC
GPW74_RS00605	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GPW74_RS00610	COG1702	phosphate starvation-inducible protein PhoH
GPW74_RS00615	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GPW74_RS00620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPW74_RS00625	COG2190	(PTS) system
GPW74_RS00635	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPW74_RS00645	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GPW74_RS00650	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
GPW74_RS00655	COG3115	cell septum assembly
GPW74_RS00660	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GPW74_RS00675	COG0789	Transcriptional regulator
GPW74_RS00680	COG1585	Membrane protein implicated in regulation of membrane protease activity
GPW74_RS00685	COG0330	HflC and HflK could
GPW74_RS00690	COG3118	belongs to the thioredoxin family
GPW74_RS00700	COG0300	oxidoreductase activity
GPW74_RS00710	COG0622	Phosphoesterase
GPW74_RS00725	COG3710	Transcriptional regulator
GPW74_RS00730	COG0326	Molecular chaperone. Has ATPase activity
GPW74_RS00735	COG0563	adenylate kinase activity
GPW74_RS00740	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GPW74_RS00755	COG0367	asparagine synthase
GPW74_RS00760	COG4651	solute:proton antiporter activity
GPW74_RS00760	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GPW74_RS00765	COG1846	Transcriptional regulator
GPW74_RS00765	COG1940	carbohydrate kinase activity
GPW74_RS00770	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GPW74_RS00775	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPW74_RS00775	COG1263	PTS System
GPW74_RS00775	COG2190	(PTS) system
GPW74_RS00780	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPW74_RS00790	COG0101	tRNA pseudouridine synthase activity
GPW74_RS00795	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GPW74_RS00800	COG0285	dihydrofolate synthase activity
GPW74_RS00805	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
GPW74_RS00810	COG1286	toxin biosynthetic process
GPW74_RS00815	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GPW74_RS00820	COG2056	Na+-H+ antiporter family
GPW74_RS00840	COG0346	lactoylglutathione lyase activity
GPW74_RS00845	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GPW74_RS00850	COG4660	Part of a membrane complex involved in electron transport
GPW74_RS00855	COG4659	FMN binding
GPW74_RS00860	COG4658	electron transport chain
GPW74_RS00865	COG4656	Part of a membrane complex involved in electron transport
GPW74_RS00870	COG2878	Part of a membrane complex involved in electron transport
GPW74_RS00875	COG4657	Part of a membrane complex involved in electron transport
GPW74_RS00885	COG0556	nucleotide-excision repair
GPW74_RS00890	COG2204	response regulator
GPW74_RS00895	COG2198	Histidine kinase
GPW74_RS00900	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GPW74_RS00905	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GPW74_RS00910	COG0521	Mo-molybdopterin cofactor biosynthetic process
GPW74_RS00915	COG0315	cyclic pyranopterin monophosphate synthase activity
GPW74_RS00920	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GPW74_RS00925	COG0314	molybdopterin synthase activity
GPW74_RS00930	COG2199	diguanylate cyclase activity
GPW74_RS00935	COG4109	DRTGG domain
GPW74_RS00945	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
GPW74_RS00960	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPW74_RS00960	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPW74_RS00965	COG0489	protein tyrosine kinase activity
GPW74_RS00970	COG0572	uridine kinase
GPW74_RS00975	COG2982	Protein involved in outer membrane biogenesis
GPW74_RS00980	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
GPW74_RS00985	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GPW74_RS00995	COG2067	long-chain fatty acid transport protein
GPW74_RS01010	COG0183	Belongs to the thiolase family
GPW74_RS01015	COG1024	Enoyl-CoA hydratase
GPW74_RS01015	COG1250	3-hydroxyacyl-CoA dehydrogenase
GPW74_RS01020	COG0778	Nitroreductase
GPW74_RS01025	COG0583	DNA-binding transcription factor activity
GPW74_RS01030	COG0745	RESPONSE REGULATOR receiver
GPW74_RS01040	COG2832	Protein of unknown function (DUF454)
GPW74_RS01045	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GPW74_RS01055	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GPW74_RS01060	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GPW74_RS01075	COG1028	Short-chain dehydrogenase reductase Sdr
GPW74_RS01080	COG0616	signal peptide processing
GPW74_RS01090	COG1522	sequence-specific DNA binding
GPW74_RS01095	COG1946	Acyl-CoA thioesterase
GPW74_RS01115	COG3706	GGDEF domain
GPW74_RS01125	COG0640	Transcriptional regulator
GPW74_RS01130	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPW74_RS01155	COG1881	PFAM PEBP family protein
GPW74_RS01175	COG0009	L-threonylcarbamoyladenylate synthase
GPW74_RS01190	COG2201	protein-glutamate methylesterase activity
GPW74_RS01200	COG5002	protein histidine kinase activity
GPW74_RS01205	COG4191	Histidine kinase
GPW74_RS01210	COG5001	Diguanylate cyclase
GPW74_RS01210	COG3300	MHYT domain
GPW74_RS01215	COG2204	response regulator
GPW74_RS01235	COG0601	transmembrane transport
GPW74_RS01240	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPW74_RS01245	COG0444	Belongs to the ABC transporter superfamily
GPW74_RS01250	COG4608	Belongs to the ABC transporter superfamily
GPW74_RS01255	COG0435	Glutathione S-transferase
GPW74_RS01260	COG0280	phosphate acetyltransferase
GPW74_RS01260	COG0857	belongs to the CobB CobQ family
GPW74_RS01265	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GPW74_RS01270	COG3092	negative regulation of chromosome organization
GPW74_RS01275	COG4628	conserved protein (DUF2132)
GPW74_RS01285	COG4120	Belongs to the binding-protein-dependent transport system permease family
GPW74_RS01295	COG2199	diguanylate cyclase activity
GPW74_RS01295	COG2203	Gaf domain
GPW74_RS01300	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPW74_RS01305	COG0653	protein targeting
GPW74_RS01310	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GPW74_RS01315	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GPW74_RS01320	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GPW74_RS01325	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GPW74_RS01330	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GPW74_RS01335	COG0156	8-amino-7-oxononanoate synthase activity
GPW74_RS01340	COG2226	methyltransferase
GPW74_RS01345	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GPW74_RS01355	COG0501	Belongs to the peptidase M48B family
GPW74_RS01365	COG0300	oxidoreductase activity
GPW74_RS01380	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GPW74_RS01390	COG2268	Band 7 protein
GPW74_RS01400	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GPW74_RS01405	COG2915	High frequency lysogenization protein hflD homolog
GPW74_RS01410	COG0482	sulfurtransferase activity
GPW74_RS01415	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPW74_RS01420	COG2916	Histone family protein nucleoid-structuring protein H-NS
GPW74_RS01425	COG1757	Na H antiporter
GPW74_RS01430	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GPW74_RS01435	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GPW74_RS01440	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GPW74_RS01445	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
GPW74_RS01445	COG0131	Imidazoleglycerol-phosphate dehydratase
GPW74_RS01450	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GPW74_RS01455	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GPW74_RS01460	COG0107	imidazoleglycerol-phosphate synthase activity
GPW74_RS01465	COG0140	phosphoribosyl-ATP diphosphatase activity
GPW74_RS01465	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GPW74_RS01505	COG1187	pseudouridine synthase activity
GPW74_RS01515	COG1278	Cold shock
GPW74_RS01520	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GPW74_RS01525	COG0542	response to heat
GPW74_RS01535	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPW74_RS01540	COG1454	alcohol dehydrogenase
GPW74_RS01540	COG1012	belongs to the aldehyde dehydrogenase family
GPW74_RS01545	COG1737	Transcriptional regulator
GPW74_RS01550	COG0076	glutamate decarboxylase activity
GPW74_RS01560	COG2431	L-lysine efflux transmembrane transporter activity
GPW74_RS01570	COG3070	regulator of competence-specific genes
GPW74_RS01585	COG3852	Histidine kinase
GPW74_RS01595	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GPW74_RS01610	COG0189	ligase activity
GPW74_RS01610	COG4067	protein conserved in archaea
GPW74_RS01615	COG0500	methyltransferase
GPW74_RS01620	COG4106	trans-aconitate 2-methyltransferase activity
GPW74_RS01625	COG1801	Protein of unknown function DUF72
GPW74_RS01630	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GPW74_RS01635	COG1435	thymidine kinase activity
GPW74_RS01645	COG0159	tryptophan synthase activity
GPW74_RS01650	COG0133	tryptophan synthase activity
GPW74_RS01655	COG0135	phosphoribosylanthranilate isomerase activity
GPW74_RS01655	COG0134	indole-3-glycerol-phosphate synthase activity
GPW74_RS01660	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GPW74_RS01665	COG0512	Glutamine amidotransferase of anthranilate synthase
GPW74_RS01670	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GPW74_RS01680	COG0613	PHP domain protein
GPW74_RS01685	COG0009	L-threonylcarbamoyladenylate synthase
GPW74_RS01690	COG1187	pseudouridine synthase activity
GPW74_RS01695	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GPW74_RS01700	COG4988	ABC transporter
GPW74_RS01705	COG0492	ferredoxin-NADP+ reductase activity
GPW74_RS01715	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GPW74_RS01720	COG3706	GGDEF domain
GPW74_RS01725	COG2949	membrane
GPW74_RS01735	COG0281	malic enzyme
GPW74_RS01745	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GPW74_RS01765	COG2885	chlorophyll binding
GPW74_RS01780	COG0247	lactate metabolic process
GPW74_RS01780	COG0277	FAD linked oxidase domain protein
GPW74_RS01800	COG2986	histidine ammonia-lyase
GPW74_RS01805	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GPW74_RS01810	COG0010	Belongs to the arginase family
GPW74_RS01815	COG1228	amidohydrolase
GPW74_RS01835	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GPW74_RS01845	COG5001	Diguanylate cyclase
GPW74_RS01850	COG0417	DNA replication proofreading
GPW74_RS01855	COG2197	response regulator
GPW74_RS01860	COG0322	excinuclease ABC activity
GPW74_RS01890	COG0745	RESPONSE REGULATOR receiver
GPW74_RS01890	COG3706	GGDEF domain
GPW74_RS01900	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GPW74_RS01905	COG0072	phenylalanine-tRNA ligase activity
GPW74_RS01905	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPW74_RS01910	COG0776	regulation of translation
GPW74_RS01925	COG0500	methyltransferase
GPW74_RS01945	COG0295	cytidine deaminase activity
GPW74_RS01950	COG1346	cytolysis
GPW74_RS01970	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPW74_RS01975	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GPW74_RS01995	COG2988	succinylglutamate desuccinylase activity
GPW74_RS02000	COG4139	cobalamin transport
GPW74_RS02005	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
GPW74_RS02050	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GPW74_RS02055	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GPW74_RS02060	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPW74_RS02080	COG2814	Major facilitator Superfamily
GPW74_RS02090	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GPW74_RS02120	COG3108	Peptidase M15
GPW74_RS02125	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPW74_RS02140	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GPW74_RS02165	COG1846	Transcriptional regulator
GPW74_RS02170	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPW74_RS02175	COG2943	transferase activity, transferring hexosyl groups
GPW74_RS02180	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
GPW74_RS02185	COG0840	transmembrane signaling receptor activity
GPW74_RS02200	COG1448	Aminotransferase
GPW74_RS02205	COG2770	Histidine kinase
GPW74_RS02205	COG3437	response regulator, receiver
GPW74_RS02210	COG0351	phosphomethylpyrimidine kinase
GPW74_RS02215	COG0017	Asparaginyl-tRNA synthetase
GPW74_RS02220	COG0840	transmembrane signaling receptor activity
GPW74_RS02225	COG0720	synthase
GPW74_RS02230	COG1760	l-serine dehydratase
GPW74_RS02235	COG0814	amino acid
GPW74_RS02240	COG0494	nUDIX hydrolase
GPW74_RS02245	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GPW74_RS02260	COG3106	COG3106 Predicted ATPase
GPW74_RS02265	COG3768	UPF0283 membrane protein
GPW74_RS02270	COG3283	Transcriptional regulator of aromatic amino acids metabolism
GPW74_RS02275	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPW74_RS02290	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPW74_RS02300	COG0471	metal ion transport
GPW74_RS02305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPW74_RS02305	COG4191	Histidine kinase
GPW74_RS02315	COG2990	Protein conserved in bacteria
GPW74_RS02320	COG3713	MltA-interacting MipA family protein
GPW74_RS02325	COG5002	protein histidine kinase activity
GPW74_RS02330	COG0745	RESPONSE REGULATOR receiver
GPW74_RS02355	COG1129	ABC transporter
GPW74_RS02410	COG2186	Transcriptional regulator
GPW74_RS02415	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GPW74_RS02420	COG0372	Belongs to the citrate synthase family
GPW74_RS02450	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPW74_RS02460	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GPW74_RS02470	COG0625	glutathione transferase activity
GPW74_RS02475	COG3437	response regulator, receiver
GPW74_RS02480	COG3437	response regulator, receiver
GPW74_RS02480	COG2205	protein histidine kinase activity
GPW74_RS02480	COG3850	Histidine kinase
GPW74_RS02480	COG4999	Histidine kinase
GPW74_RS02490	COG3706	GGDEF domain
GPW74_RS02495	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GPW74_RS02500	COG1254	Belongs to the acylphosphatase family
GPW74_RS02505	COG2920	part of a sulfur-relay system
GPW74_RS02510	COG0670	Belongs to the BI1 family
GPW74_RS02515	COG1126	abc transporter atp-binding protein
GPW74_RS02520	COG0765	amino acid transport
GPW74_RS02525	COG4597	amino acid ABC transporter
GPW74_RS02530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPW74_RS02540	COG0561	phosphatase activity
GPW74_RS02545	COG0602	queuosine metabolic process
GPW74_RS02550	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GPW74_RS02580	COG3706	GGDEF domain
GPW74_RS02585	COG0443	Heat shock 70 kDa protein
GPW74_RS02590	COG0443	Heat shock 70 kDa protein
GPW74_RS02620	COG1643	Atp-dependent helicase
GPW74_RS02630	COG0443	Heat shock 70 kDa protein
GPW74_RS02635	COG0095	Lipoate-protein ligase
GPW74_RS02650	COG0477	Major facilitator Superfamily
GPW74_RS02655	COG0415	Belongs to the DNA photolyase family
GPW74_RS02660	COG2076	Multidrug Resistance protein
GPW74_RS02665	COG0513	Belongs to the DEAD box helicase family
GPW74_RS02670	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GPW74_RS02680	COG3501	Rhs element vgr protein
GPW74_RS02700	COG1280	lysine exporter protein (LysE YggA)
GPW74_RS02705	COG1115	amino acid carrier protein
GPW74_RS02720	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPW74_RS02725	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPW74_RS02730	COG1177	transmembrane transport
GPW74_RS02735	COG1176	ABC-type spermidine putrescine transport system, permease component I
GPW74_RS02740	COG3842	ATPase activity
GPW74_RS02760	COG0037	tRNA processing
GPW74_RS02765	COG0589	response to stress
GPW74_RS02770	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPW74_RS02785	COG2217	Heavy metal translocating P-type atpase
GPW74_RS02795	COG2010	Cytochrome c
GPW74_RS02810	COG3278	Belongs to the heme-copper respiratory oxidase family
GPW74_RS02825	COG0784	Response regulator, receiver
GPW74_RS02825	COG2205	protein histidine kinase activity
GPW74_RS02850	COG2994	toxin metabolic process
GPW74_RS02940	COG3120	sequence-specific DNA binding
GPW74_RS02945	COG1067	ATP-dependent peptidase activity
GPW74_RS02950	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPW74_RS02975	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GPW74_RS02975	COG0116	Belongs to the methyltransferase superfamily
GPW74_RS02985	COG0167	dihydroorotate dehydrogenase activity
GPW74_RS03000	COG0308	aminopeptidase N
GPW74_RS03015	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
GPW74_RS03020	COG1956	GAF domain-containing protein
GPW74_RS03025	COG1132	(ABC) transporter
GPW74_RS03030	COG2995	paraquat-inducible protein a
GPW74_RS03035	COG3008	intermembrane lipid transfer
GPW74_RS03040	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GPW74_RS03040	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
GPW74_RS03060	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPW74_RS03070	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GPW74_RS03085	COG0437	4 iron, 4 sulfur cluster binding
GPW74_RS03090	COG3383	formate dehydrogenase (NAD+) activity
GPW74_RS03090	COG3383	formate dehydrogenase (NAD+) activity
GPW74_RS03120	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GPW74_RS03125	COG0488	(ABC) transporter
GPW74_RS03130	COG3852	Histidine kinase
GPW74_RS03135	COG2204	response regulator
GPW74_RS03145	COG4662	Binding-protein-dependent transport system inner membrane component
GPW74_RS03155	COG0746	molybdenum cofactor guanylyltransferase activity
GPW74_RS03160	COG0303	'Molybdopterin
GPW74_RS03180	COG1940	carbohydrate kinase activity
GPW74_RS03195	COG0840	transmembrane signaling receptor activity
GPW74_RS03200	COG0791	NLP P60 protein
GPW74_RS03220	COG0534	Mate efflux family protein
GPW74_RS03230	COG1793	dna ligase
GPW74_RS03240	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GPW74_RS03245	COG0848	biopolymer transport protein
GPW74_RS03250	COG0811	peptide transport
GPW74_RS03255	COG0811	peptide transport
GPW74_RS03270	COG1175	transmembrane transport
GPW74_RS03275	COG0395	ABC-type sugar transport system, permease component
GPW74_RS03285	COG1349	DNA-binding transcription factor activity
GPW74_RS03290	COG0584	glycerophosphoryl diester phosphodiesterase
GPW74_RS03295	COG2731	YhcH YjgK YiaL family protein
GPW74_RS03300	COG0251	oxidation-reduction process
GPW74_RS03305	COG1609	Transcriptional regulator
GPW74_RS03310	COG2723	6-phospho-beta-galactosidase activity
GPW74_RS03315	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
GPW74_RS03320	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GPW74_RS03335	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GPW74_RS03340	COG2816	NAD+ diphosphatase activity
GPW74_RS03365	COG0577	efflux transmembrane transporter activity
GPW74_RS03365	COG1136	(ABC) transporter
GPW74_RS03370	COG0577	efflux transmembrane transporter activity
GPW74_RS03370	COG1136	(ABC) transporter
GPW74_RS03375	COG1136	(ABC) transporter
GPW74_RS03375	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPW74_RS03380	COG1294	oxidase, subunit
GPW74_RS03425	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GPW74_RS03435	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GPW74_RS03455	COG0753	catalase activity
GPW74_RS03475	COG0693	protein deglycase activity
GPW74_RS03480	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPW74_RS03490	COG0346	lactoylglutathione lyase activity
GPW74_RS03500	COG3527	Alpha-acetolactate decarboxylase
GPW74_RS03515	COG2199	diguanylate cyclase activity
GPW74_RS03515	COG2200	EAL domain
GPW74_RS03520	COG3706	GGDEF domain
GPW74_RS03525	COG2017	converts alpha-aldose to the beta-anomer
GPW74_RS03530	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GPW74_RS03535	COG1085	galactose-1-phosphate uridylyltransferase
GPW74_RS03555	COG3706	GGDEF domain
GPW74_RS03555	COG0745	RESPONSE REGULATOR receiver
GPW74_RS03575	COG0784	Response regulator, receiver
GPW74_RS03575	COG0835	chemotaxis
GPW74_RS03585	COG4565	transcriptional regulatory protein
GPW74_RS03590	COG3290	protein histidine kinase activity
GPW74_RS03605	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPW74_RS03625	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GPW74_RS03630	COG3063	Type IV pilus biogenesis stability protein PilW
GPW74_RS03645	COG1451	nucleotide metabolic process
GPW74_RS03655	COG0583	DNA-binding transcription factor activity
GPW74_RS03675	COG1538	Outer membrane efflux protein
GPW74_RS03685	COG0019	diaminopimelate decarboxylase activity
GPW74_RS03690	COG1748	Saccharopine dehydrogenase
GPW74_RS03715	COG4181	ATPase activity
GPW74_RS03720	COG0534	Mate efflux family protein
GPW74_RS03725	COG0702	epimerase
GPW74_RS03735	COG2814	Major facilitator Superfamily
GPW74_RS03740	COG1187	pseudouridine synthase activity
GPW74_RS03745	COG1061	Type III restriction enzyme res subunit
GPW74_RS03760	COG5002	protein histidine kinase activity
GPW74_RS03765	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GPW74_RS03775	COG0840	transmembrane signaling receptor activity
GPW74_RS03810	COG4934	collagen metabolic process
GPW74_RS03830	COG2239	Acts as a magnesium transporter
GPW74_RS03840	COG0814	amino acid
GPW74_RS03850	COG3313	Fe-S protein
GPW74_RS03860	COG4134	Bacterial extracellular solute-binding protein
GPW74_RS03865	COG4135	transport system, permease component
GPW74_RS03870	COG4136	ATPase activity
GPW74_RS03875	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GPW74_RS03880	COG0564	pseudouridine synthase activity
GPW74_RS03900	COG0733	neurotransmitter:sodium symporter activity
GPW74_RS03910	COG0626	cystathionine gamma-synthase activity
GPW74_RS03915	COG2818	Glycosylase
GPW74_RS03930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPW74_RS03945	COG1842	Phage shock protein A
GPW74_RS03950	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GPW74_RS03955	COG0747	negative chemotaxis
GPW74_RS03960	COG4168	peptide transport system, permease
GPW74_RS03965	COG4171	peptide transport system, permease
GPW74_RS03975	COG4172	Belongs to the ABC transporter superfamily
GPW74_RS04000	COG1227	inorganic diphosphatase activity
GPW74_RS04020	COG0243	molybdopterin cofactor binding
GPW74_RS04025	COG3005	denitrification pathway
GPW74_RS04030	COG4459	periplasmic nitrate reductase
GPW74_RS04035	COG2116	formate transmembrane transporter activity
GPW74_RS04045	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GPW74_RS04050	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GPW74_RS04060	COG2917	probably involved in intracellular septation
GPW74_RS04065	COG1607	acyl-coa hydrolase
GPW74_RS04070	COG2350	Protein conserved in bacteria
GPW74_RS04080	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GPW74_RS04105	COG5001	Diguanylate cyclase
GPW74_RS04110	COG1032	radical SAM domain protein
GPW74_RS04130	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
GPW74_RS04135	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
GPW74_RS04140	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GPW74_RS04145	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GPW74_RS04150	COG0745	RESPONSE REGULATOR receiver
GPW74_RS04155	COG3381	protein complex oligomerization
GPW74_RS04160	COG1609	Transcriptional regulator
GPW74_RS04165	COG3070	regulator of competence-specific genes
GPW74_RS04185	COG0297	glycogen (starch) synthase activity
GPW74_RS04190	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GPW74_RS04195	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GPW74_RS04205	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GPW74_RS04215	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GPW74_RS04220	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
GPW74_RS04225	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GPW74_RS04230	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GPW74_RS04235	COG1960	acyl-CoA dehydrogenase activity
GPW74_RS04255	COG1012	belongs to the aldehyde dehydrogenase family
GPW74_RS04260	COG1309	transcriptional regulator
GPW74_RS04265	COG2995	paraquat-inducible protein a
GPW74_RS04270	COG3008	intermembrane lipid transfer
GPW74_RS04270	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GPW74_RS04280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPW74_RS04295	COG0582	viral genome integration into host DNA
GPW74_RS04305	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GPW74_RS04370	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GPW74_RS04410	COG2003	Belongs to the UPF0758 family
GPW74_RS04475	COG0415	Belongs to the DNA photolyase family
GPW74_RS04485	COG4628	conserved protein (DUF2132)
GPW74_RS04490	COG3284	Transcriptional regulator
GPW74_RS04495	COG1012	belongs to the aldehyde dehydrogenase family
GPW74_RS04505	COG0784	Response regulator, receiver
GPW74_RS04505	COG5002	protein histidine kinase activity
GPW74_RS04515	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GPW74_RS04525	COG2885	chlorophyll binding
GPW74_RS04530	COG0823	Involved in the tonB-independent uptake of proteins
GPW74_RS04545	COG0811	peptide transport
GPW74_RS04550	COG0824	Thioesterase
GPW74_RS04555	COG3790	cyd operon protein YbgE
GPW74_RS04560	COG4890	Cyd operon protein YbgT
GPW74_RS04565	COG1294	oxidase, subunit
GPW74_RS04570	COG1271	oxidase subunit
GPW74_RS04575	COG2255	four-way junction helicase activity
GPW74_RS04580	COG0632	four-way junction helicase activity
GPW74_RS04585	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GPW74_RS04590	COG0215	cysteine-tRNA ligase activity
GPW74_RS04595	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GPW74_RS04600	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPW74_RS04605	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GPW74_RS04615	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GPW74_RS04625	COG1199	ATP-dependent helicase activity
GPW74_RS04630	COG0730	response to heat
GPW74_RS04635	COG3923	Primosomal replication protein n
GPW74_RS04645	COG0708	Exodeoxyribonuclease III
GPW74_RS04650	COG4160	amino acid transport
GPW74_RS04655	COG4215	(ABC) transporter
GPW74_RS04675	COG1882	Formate acetyltransferase
GPW74_RS04685	COG0840	transmembrane signaling receptor activity
GPW74_RS04690	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GPW74_RS04700	COG3013	Belongs to the UPF0304 family
GPW74_RS04710	COG2718	Belongs to the UPF0229 family
GPW74_RS04715	COG2719	SpoVR family
GPW74_RS04720	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GPW74_RS04730	COG1663	tetraacyldisaccharide 4'-kinase activity
GPW74_RS04735	COG1132	(ABC) transporter
GPW74_RS04740	COG0658	competence protein
GPW74_RS04740	COG2333	competence protein COMEC
GPW74_RS04755	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPW74_RS04760	COG1136	(ABC) transporter
GPW74_RS04765	COG4591	ABC-type transport system involved in lipoprotein release permease component
GPW74_RS04775	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GPW74_RS04800	COG1252	NADH dehydrogenase
GPW74_RS04830	COG0537	adenosine 5'-monophosphoramidase activity
GPW74_RS04845	COG2186	Transcriptional regulator
GPW74_RS04850	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GPW74_RS04855	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GPW74_RS04875	COG0686	Belongs to the AlaDH PNT family
GPW74_RS04885	COG0583	DNA-binding transcription factor activity
GPW74_RS04900	COG0284	orotidine-5'-phosphate decarboxylase activity
GPW74_RS04905	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
GPW74_RS04910	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
GPW74_RS04915	COG0776	regulation of translation
GPW74_RS04920	COG0539	negative regulation of cytoplasmic translation
GPW74_RS04925	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GPW74_RS04930	COG1555	photosystem II stabilization
GPW74_RS04935	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPW74_RS04940	COG0776	regulation of translation
GPW74_RS04945	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GPW74_RS04950	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GPW74_RS04960	COG0544	peptidyl-prolyl cis-trans isomerase activity
GPW74_RS04970	COG4191	Histidine kinase
GPW74_RS04980	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GPW74_RS04985	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GPW74_RS04990	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GPW74_RS04995	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GPW74_RS05040	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GPW74_RS05055	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPW74_RS05075	COG0243	molybdopterin cofactor binding
GPW74_RS05080	COG3005	denitrification pathway
GPW74_RS05085	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPW74_RS05095	COG2951	lytic endotransglycosylase activity
GPW74_RS05100	COG3100	YcgL domain-containing protein
GPW74_RS05105	COG0850	regulation of cytokinetic process
GPW74_RS05110	COG2894	cell division
GPW74_RS05115	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
GPW74_RS05120	COG3015	lipoprotein NlpE involved in copper resistance
GPW74_RS05145	COG3135	benzoate transporter
GPW74_RS05155	COG1441	menaquinone biosynthetic process
GPW74_RS05165	COG0596	Alpha beta hydrolase
GPW74_RS05170	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GPW74_RS05175	COG1169	isochorismate synthase
GPW74_RS05180	COG0436	Aminotransferase
GPW74_RS05185	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
GPW74_RS05190	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GPW74_RS05200	COG0705	Rhomboid family
GPW74_RS05205	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GPW74_RS05210	COG0318	PFAM AMP-dependent synthetase and ligase
GPW74_RS05215	COG0596	Alpha beta hydrolase
GPW74_RS05230	COG1214	PFAM Peptidase M22, glycoprotease
GPW74_RS05235	COG1199	ATP-dependent helicase activity
GPW74_RS05245	COG0788	formyltetrahydrofolate deformylase activity
GPW74_RS05250	COG1902	pentaerythritol trinitrate reductase activity
GPW74_RS05250	COG0446	pyridine nucleotide-disulphide oxidoreductase
GPW74_RS05255	COG0616	signal peptide processing
GPW74_RS05260	COG0252	asparaginase activity
GPW74_RS05265	COG3139	Protein of unknown function (DUF1315)
GPW74_RS05275	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPW74_RS05280	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPW74_RS05285	COG0676	glucose-6-phosphate 1-epimerase activity
GPW74_RS05295	COG2226	methyltransferase
GPW74_RS05310	COG0835	chemotaxis
GPW74_RS05310	COG0784	Response regulator, receiver
GPW74_RS05315	COG1940	carbohydrate kinase activity
GPW74_RS05325	COG4667	esterase of the alpha-beta hydrolase superfamily
GPW74_RS05340	COG0733	neurotransmitter:sodium symporter activity
GPW74_RS05350	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPW74_RS05350	COG1263	PTS System
GPW74_RS05355	COG0084	hydrolase, TatD family'
GPW74_RS05365	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GPW74_RS05370	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GPW74_RS05375	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GPW74_RS05380	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPW74_RS05385	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GPW74_RS05390	COG1028	Short-chain dehydrogenase reductase Sdr
GPW74_RS05395	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GPW74_RS05400	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GPW74_RS05405	COG0416	fatty acid biosynthetic process
GPW74_RS05410	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GPW74_RS05415	COG1399	metal-binding, possibly nucleic acid-binding protein
GPW74_RS05420	COG0424	maF-like protein
GPW74_RS05425	COG0564	pseudouridine synthase activity
GPW74_RS05430	COG1530	ribonuclease E activity
GPW74_RS05440	COG1012	belongs to the aldehyde dehydrogenase family
GPW74_RS05440	COG1454	alcohol dehydrogenase
GPW74_RS05445	COG2095	MarC family integral membrane protein
GPW74_RS05450	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GPW74_RS05455	COG1757	Na H antiporter
GPW74_RS05465	COG3081	Nucleoid-associated protein
GPW74_RS05475	COG3083	sulfuric ester hydrolase activity
GPW74_RS05490	COG0123	including yeast histone deacetylase and acetoin utilization protein
GPW74_RS05495	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GPW74_RS05500	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GPW74_RS05520	COG2853	Lipoprotein
GPW74_RS05530	COG4235	cytochrome complex assembly
GPW74_RS05530	COG3088	subunit of a heme lyase
GPW74_RS05535	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GPW74_RS05540	COG1138	Cytochrome C-type biogenesis protein
GPW74_RS05545	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
GPW74_RS05555	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPW74_RS05560	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GPW74_RS05565	COG4133	protoheme IX ABC transporter activity
GPW74_RS05575	COG0835	chemotaxis
GPW74_RS05585	COG1192	Involved in chromosome partitioning
GPW74_RS05590	COG2201	protein-glutamate methylesterase activity
GPW74_RS05595	COG2198	Histidine kinase
GPW74_RS05595	COG0643	Histidine kinase
GPW74_RS05600	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
GPW74_RS05615	COG0455	bacterial-type flagellum organization
GPW74_RS05630	COG2062	phosphohistidine phosphatase, SixA
GPW74_RS05635	COG1025	Belongs to the peptidase M16 family
GPW74_RS05645	COG0018	arginyl-trna synthetase
GPW74_RS05665	COG1918	ferrous iron import across plasma membrane
GPW74_RS05675	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
GPW74_RS05680	COG1121	(ABC) transporter
GPW74_RS05685	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GPW74_RS05695	COG0045	succinate-CoA ligase (ADP-forming) activity
GPW74_RS05700	COG0508	dehydrogenase complex catalyzes the overall conversion of
GPW74_RS05705	COG0567	Dehydrogenase, E1 component
GPW74_RS05715	COG1053	succinate dehydrogenase
GPW74_RS05720	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GPW74_RS05725	COG2009	succinate dehydrogenase
GPW74_RS05730	COG0372	Belongs to the citrate synthase family
GPW74_RS05735	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GPW74_RS05745	COG0033	Phosphoglucomutase
GPW74_RS05750	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
GPW74_RS05755	COG0596	Alpha beta hydrolase
GPW74_RS05770	COG1346	cytolysis
GPW74_RS05780	COG0583	DNA-binding transcription factor activity
GPW74_RS05790	COG0735	belongs to the Fur family
GPW74_RS05795	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GPW74_RS05800	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPW74_RS05805	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GPW74_RS05810	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPW74_RS05810	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GPW74_RS05815	COG0431	NADPH-dependent FMN reductase
GPW74_RS05825	COG3101	peptidyl-lysine hydroxylation
GPW74_RS05830	COG2860	membrane
GPW74_RS05835	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GPW74_RS05840	COG2890	protein-(glutamine-N5) methyltransferase activity
GPW74_RS05855	COG1684	flagellar biosynthetic protein fliR
GPW74_RS05860	COG1987	bacterial-type flagellum assembly
GPW74_RS05885	COG1580	Controls the rotational direction of flagella during chemotaxis
GPW74_RS05910	COG1317	bacterial-type flagellum organization
GPW74_RS05915	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GPW74_RS05925	COG1677	Flagellar hook-basal body complex protein FliE
GPW74_RS05930	COG2204	response regulator
GPW74_RS05935	COG4191	Histidine kinase
GPW74_RS05940	COG2204	response regulator
GPW74_RS05945	COG1516	flagellar protein fliS
GPW74_RS05955	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GPW74_RS05960	COG1334	flagellar protein FlaG
GPW74_RS05965	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPW74_RS05970	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPW74_RS05975	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPW74_RS05980	COG2837	iron assimilation
GPW74_RS06000	COG1393	Belongs to the ArsC family
GPW74_RS06005	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPW74_RS06010	COG1876	peptidase activity
GPW74_RS06020	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
GPW74_RS06035	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GPW74_RS06055	COG4783	chaperone-mediated protein folding
GPW74_RS06060	COG1393	Belongs to the ArsC family
GPW74_RS06080	COG2233	PERMEase
GPW74_RS06085	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GPW74_RS06090	COG0737	Belongs to the 5'-nucleotidase family
GPW74_RS06095	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GPW74_RS06100	COG2912	Transglutaminase-like superfamily
GPW74_RS06105	COG3094	Invasion gene expression up-regulator, SirB
GPW74_RS06110	COG2890	protein-(glutamine-N5) methyltransferase activity
GPW74_RS06115	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GPW74_RS06120	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GPW74_RS06125	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
GPW74_RS06130	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GPW74_RS06135	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GPW74_RS06140	COG0193	aminoacyl-tRNA hydrolase activity
GPW74_RS06145	COG0012	GTP binding
GPW74_RS06230	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPW74_RS06235	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GPW74_RS06255	COG1705	Flagellar rod assembly protein muramidase FlgJ
GPW74_RS06255	COG3951	Flagellar rod assembly protein muramidase FlgJ
GPW74_RS06260	COG1706	bacterial-type flagellum-dependent cell motility
GPW74_RS06265	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GPW74_RS06270	COG4786	Flagellar basal body rod
GPW74_RS06275	COG4787	bacterial-type flagellum-dependent cell motility
GPW74_RS06280	COG1749	Flagellar hook protein flgE
GPW74_RS06285	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GPW74_RS06290	COG1558	bacterial-type flagellum-dependent cell motility
GPW74_RS06295	COG1815	bacterial-type flagellum-dependent cell motility
GPW74_RS06300	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GPW74_RS06305	COG0835	chemotaxis
GPW74_RS06305	COG0784	Response regulator, receiver
GPW74_RS06345	COG2375	cellular response to nickel ion
GPW74_RS06350	COG4774	siderophore transport
GPW74_RS06350	COG1629	transport
GPW74_RS06365	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPW74_RS06370	COG2608	mercury ion transmembrane transporter activity
GPW74_RS06370	COG2217	Heavy metal translocating P-type atpase
GPW74_RS06400	COG2840	Smr protein MutS2
GPW74_RS06405	COG1187	pseudouridine synthase activity
GPW74_RS06410	COG3706	GGDEF domain
GPW74_RS06415	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GPW74_RS06420	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GPW74_RS06425	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GPW74_RS06430	COG0121	glutamine amidotransferase
GPW74_RS06435	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GPW74_RS06440	COG1960	acyl-CoA dehydrogenase activity
GPW74_RS06450	COG1294	oxidase, subunit
GPW74_RS06470	COG3220	belongs to the UPF0276 family
GPW74_RS06490	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GPW74_RS06495	COG0328	RNA-DNA hybrid ribonuclease activity
GPW74_RS06500	COG2226	methyltransferase
GPW74_RS06505	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GPW74_RS06510	COG1388	LysM domain
GPW74_RS06510	COG0741	lytic transglycosylase activity
GPW74_RS06520	COG0347	Belongs to the P(II) protein family
GPW74_RS06525	COG3479	Phenolic acid decarboxylase
GPW74_RS06535	COG0037	tRNA processing
GPW74_RS06540	COG0825	malonyl-CoA metabolic process
GPW74_RS06545	COG0587	DNA-directed DNA polymerase activity
GPW74_RS06550	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GPW74_RS06555	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPW74_RS06560	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPW74_RS06565	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GPW74_RS06570	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GPW74_RS06575	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
GPW74_RS06585	COG0750	zinc metalloprotease
GPW74_RS06590	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GPW74_RS06595	COG0575	Belongs to the CDS family
GPW74_RS06600	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GPW74_RS06605	COG0233	cytoplasmic translational termination
GPW74_RS06610	COG0528	UMP kinase activity
GPW74_RS06615	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GPW74_RS06620	COG0052	Belongs to the universal ribosomal protein uS2 family
GPW74_RS06625	COG0024	Methionine aminopeptidase
GPW74_RS06630	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GPW74_RS06640	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GPW74_RS06645	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GPW74_RS06650	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GPW74_RS06655	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GPW74_RS06670	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPW74_RS06670	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GPW74_RS06675	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GPW74_RS06680	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GPW74_RS06685	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GPW74_RS06700	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
GPW74_RS06705	COG2252	PERMEase
GPW74_RS06710	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPW74_RS06715	COG4067	protein conserved in archaea
GPW74_RS06715	COG0189	ligase activity
GPW74_RS06720	COG0189	ligase activity
GPW74_RS06730	COG0733	neurotransmitter:sodium symporter activity
GPW74_RS06735	COG3706	GGDEF domain
GPW74_RS06745	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GPW74_RS06755	COG1477	protein flavinylation
GPW74_RS06760	COG2871	sodium ion transport
GPW74_RS06765	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPW74_RS06770	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPW74_RS06775	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPW74_RS06780	COG1805	sodium ion transport
GPW74_RS06785	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
GPW74_RS06790	COG0271	Belongs to the BolA IbaG family
GPW74_RS06795	COG2813	Specifically methylates the guanine in position
GPW74_RS06805	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GPW74_RS06815	COG2211	Major facilitator Superfamily
GPW74_RS06825	COG1595	DNA-templated transcription, initiation
GPW74_RS06835	COG3248	Nucleoside-binding outer membrane protein
GPW74_RS06840	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GPW74_RS06845	COG0693	protein deglycase activity
GPW74_RS06850	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GPW74_RS06855	COG2166	iron-sulfur cluster assembly
GPW74_RS06860	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GPW74_RS06865	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
GPW74_RS06875	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GPW74_RS06875	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GPW74_RS06885	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GPW74_RS06890	COG1074	ATP-dependent DNA helicase activity
GPW74_RS06895	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GPW74_RS06910	COG3141	response to X-ray
GPW74_RS06915	COG2171	N-acyltransferase activity
GPW74_RS06925	COG0456	acetyltransferase
GPW74_RS06930	COG0569	domain protein
GPW74_RS06930	COG0189	ligase activity
GPW74_RS06945	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GPW74_RS06950	COG1609	Transcriptional regulator
GPW74_RS06955	COG3250	beta-galactosidase activity
GPW74_RS06970	COG1022	Amp-dependent synthetase and ligase
GPW74_RS06975	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPW74_RS06980	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GPW74_RS06990	COG0560	Phosphoserine phosphatase
GPW74_RS07000	COG0813	purine-nucleoside phosphorylase activity
GPW74_RS07005	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GPW74_RS07015	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GPW74_RS07025	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPW74_RS07030	COG0084	hydrolase, TatD family'
GPW74_RS07045	COG1115	amino acid carrier protein
GPW74_RS07060	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GPW74_RS07065	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GPW74_RS07070	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
GPW74_RS07075	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GPW74_RS07080	COG0083	homoserine kinase activity
GPW74_RS07100	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GPW74_RS07110	COG0745	RESPONSE REGULATOR receiver
GPW74_RS07115	COG5002	protein histidine kinase activity
GPW74_RS07115	COG2198	Histidine kinase
GPW74_RS07115	COG0784	Response regulator, receiver
GPW74_RS07120	COG2203	Gaf domain
GPW74_RS07120	COG3706	GGDEF domain
GPW74_RS07120	COG5001	Diguanylate cyclase
GPW74_RS07120	COG4251	negative regulation of phosphorylation
GPW74_RS07125	COG1242	4 iron, 4 sulfur cluster binding
GPW74_RS07130	COG0067	glutamate synthase
GPW74_RS07130	COG0069	glutamate synthase activity
GPW74_RS07130	COG0070	glutamate synthase
GPW74_RS07140	COG0067	glutamate synthase
GPW74_RS07140	COG0069	glutamate synthase activity
GPW74_RS07140	COG0070	glutamate synthase
GPW74_RS07145	COG0493	'glutamate synthase
GPW74_RS07155	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GPW74_RS07165	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GPW74_RS07170	COG2860	membrane
GPW74_RS07175	COG0583	DNA-binding transcription factor activity
GPW74_RS07180	COG0730	response to heat
GPW74_RS07200	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GPW74_RS07205	COG0505	Belongs to the CarA family
GPW74_RS07215	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GPW74_RS07220	COG0494	nUDIX hydrolase
GPW74_RS07225	COG0653	protein targeting
GPW74_RS07235	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
GPW74_RS07240	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GPW74_RS07245	COG0849	cell division
GPW74_RS07250	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GPW74_RS07255	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GPW74_RS07260	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GPW74_RS07265	COG0772	Belongs to the SEDS family
GPW74_RS07270	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GPW74_RS07275	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GPW74_RS07280	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GPW74_RS07285	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GPW74_RS07290	COG0768	penicillin binding
GPW74_RS07295	COG3116	cell division
GPW74_RS07300	COG0275	rRNA processing
GPW74_RS07310	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPW74_RS07315	COG0508	dehydrogenase complex catalyzes the overall conversion of
GPW74_RS07320	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
GPW74_RS07325	COG2186	Transcriptional regulator
GPW74_RS07330	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GPW74_RS07335	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPW74_RS07340	COG4974	Belongs to the 'phage' integrase family
GPW74_RS07345	COG0716	FMN binding
GPW74_RS07365	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPW74_RS07370	COG1459	type II secretion system
GPW74_RS07380	COG0237	dephospho-CoA kinase activity
GPW74_RS07385	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
GPW74_RS07390	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GPW74_RS07395	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GPW74_RS07400	COG0187	DNA topoisomerase II activity
GPW74_RS07405	COG3150	esterase
GPW74_RS07415	COG3151	Protein conserved in bacteria
GPW74_RS07420	COG0494	nUDIX hydrolase
GPW74_RS07425	COG1538	Outer membrane efflux protein
GPW74_RS07435	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GPW74_RS07440	COG0840	transmembrane signaling receptor activity
GPW74_RS07445	COG3025	triphosphatase activity
GPW74_RS07450	COG1392	Phosphate transport regulator
GPW74_RS07455	COG0306	phosphate transporter
GPW74_RS07460	COG4991	sh3 domain protein
GPW74_RS07470	COG3409	Peptidoglycan-binding domain 1 protein
GPW74_RS07470	COG3267	Type II secretory pathway component ExeA
GPW74_RS07475	COG0617	tRNA 3'-terminal CCA addition
GPW74_RS07480	COG0148	phosphopyruvate hydratase activity
GPW74_RS07485	COG0504	CTP synthase activity
GPW74_RS07490	COG3956	TIGRFAM MazG family protein
GPW74_RS07495	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GPW74_RS07500	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPW74_RS07510	COG5001	Diguanylate cyclase
GPW74_RS07525	COG0736	holo-[acyl-carrier-protein] synthase activity
GPW74_RS07530	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GPW74_RS07535	COG1381	Involved in DNA repair and RecF pathway recombination
GPW74_RS07540	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GPW74_RS07545	COG0571	ribonuclease III activity
GPW74_RS07550	COG0681	Belongs to the peptidase S26 family
GPW74_RS07555	COG0481	GTPase activity
GPW74_RS07560	COG3086	response to oxidative stress
GPW74_RS07565	COG3026	antisigma factor binding
GPW74_RS07575	COG1595	DNA-templated transcription, initiation
GPW74_RS07580	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GPW74_RS07590	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GPW74_RS07595	COG0354	folic acid binding
GPW74_RS07605	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GPW74_RS07620	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
GPW74_RS07630	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GPW74_RS07635	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GPW74_RS07640	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GPW74_RS07645	COG0440	acetolactate synthase activity
GPW74_RS07650	COG0028	Belongs to the TPP enzyme family
GPW74_RS07660	COG0583	DNA-binding transcription factor activity
GPW74_RS07675	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GPW74_RS07680	COG0473	3-isopropylmalate dehydrogenase activity
GPW74_RS07685	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GPW74_RS07690	COG0066	3-isopropylmalate dehydratase activity
GPW74_RS07730	COG3437	response regulator, receiver
GPW74_RS07750	COG0795	lipopolysaccharide-transporting ATPase activity
GPW74_RS07755	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GPW74_RS07760	COG2927	DNA polymerase III (CHI subunit)
GPW74_RS07765	COG0525	valine-tRNA ligase activity
GPW74_RS07770	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GPW74_RS07775	COG0564	pseudouridine synthase activity
GPW74_RS07780	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GPW74_RS07785	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GPW74_RS07790	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GPW74_RS07795	COG0540	Belongs to the ATCase OTCase family
GPW74_RS07800	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
GPW74_RS07805	COG0251	oxidation-reduction process
GPW74_RS07810	COG0204	Acyl-transferase
GPW74_RS07815	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GPW74_RS07820	COG5007	Belongs to the BolA IbaG family
GPW74_RS07830	COG2854	intermembrane phospholipid transfer
GPW74_RS07835	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GPW74_RS07840	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GPW74_RS07845	COG1127	ABC transporter
GPW74_RS07855	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GPW74_RS07855	COG0517	IMP dehydrogenase activity
GPW74_RS07870	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GPW74_RS07875	COG1137	ATPase activity
GPW74_RS07885	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GPW74_RS07890	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPW74_RS07900	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPW74_RS07910	COG0312	modulator of DNA gyrase
GPW74_RS07915	COG3028	Belongs to the UPF0307 family
GPW74_RS07920	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
GPW74_RS07925	COG1178	ABC-type Fe3 transport system permease component
GPW74_RS07930	COG4143	(ABC) transporter
GPW74_RS07935	COG0163	prenyltransferase activity
GPW74_RS07940	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GPW74_RS07945	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
GPW74_RS07950	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GPW74_RS07955	COG2105	PFAM AIG2 family protein
GPW74_RS07965	COG0729	surface antigen
GPW74_RS07970	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPW74_RS07975	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
GPW74_RS07990	COG1136	(ABC) transporter
GPW74_RS08010	COG0529	Catalyzes the synthesis of activated sulfate
GPW74_RS08015	COG2895	sulfate adenylyltransferase (ATP) activity
GPW74_RS08020	COG0175	sulfate reduction
GPW74_RS08025	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GPW74_RS08025	COG1648	precorrin-2 dehydrogenase activity
GPW74_RS08030	COG0737	Belongs to the 5'-nucleotidase family
GPW74_RS08040	COG0513	Belongs to the DEAD box helicase family
GPW74_RS08045	COG2153	protein acetylation
GPW74_RS08050	COG0697	spore germination
GPW74_RS08055	COG3061	Opacity-associated protein A
GPW74_RS08055	COG3266	domain, Protein
GPW74_RS08060	COG0545	Peptidyl-prolyl cis-trans isomerase
GPW74_RS08070	COG0203	ribosomal protein L17
GPW74_RS08075	COG0202	RNA polymerase activity
GPW74_RS08080	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GPW74_RS08085	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GPW74_RS08090	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GPW74_RS08100	COG0201	protein transport
GPW74_RS08105	COG0200	Binds to the 23S rRNA
GPW74_RS08110	COG1841	ribosomal large subunit assembly
GPW74_RS08115	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GPW74_RS08120	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GPW74_RS08125	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GPW74_RS08130	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GPW74_RS08135	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GPW74_RS08140	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GPW74_RS08145	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GPW74_RS08150	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GPW74_RS08155	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GPW74_RS08160	COG0255	Belongs to the universal ribosomal protein uL29 family
GPW74_RS08165	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GPW74_RS08170	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GPW74_RS08175	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GPW74_RS08180	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GPW74_RS08185	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GPW74_RS08190	COG0089	rRNA binding
GPW74_RS08195	COG0088	Forms part of the polypeptide exit tunnel
GPW74_RS08200	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GPW74_RS08205	COG0051	transcription antitermination factor activity, RNA binding
GPW74_RS08210	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GPW74_RS08215	COG0557	exoribonuclease II activity
GPW74_RS08225	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
GPW74_RS08230	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GPW74_RS08240	COG1047	Peptidyl-prolyl cis-trans
GPW74_RS08255	COG2249	NAD(P)H dehydrogenase (quinone) activity
GPW74_RS08260	COG0488	(ABC) transporter
GPW74_RS08270	COG0429	hydrolase of the alpha beta-hydrolase fold
GPW74_RS08280	COG3954	Phosphoribulokinase
GPW74_RS08285	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GPW74_RS08295	COG1012	belongs to the aldehyde dehydrogenase family
GPW74_RS08305	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GPW74_RS08315	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GPW74_RS08335	COG0180	Tryptophanyl-tRNA synthetase
GPW74_RS08340	COG0546	phosphoglycolate phosphatase activity
GPW74_RS08345	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GPW74_RS08350	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GPW74_RS08360	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GPW74_RS08365	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GPW74_RS08395	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GPW74_RS08405	COG0678	peroxiredoxin activity
GPW74_RS08405	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GPW74_RS08410	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPW74_RS08420	COG0165	Argininosuccinate lyase
GPW74_RS08425	COG0137	argininosuccinate synthase activity
GPW74_RS08430	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GPW74_RS08435	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GPW74_RS08440	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GPW74_RS08445	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GPW74_RS08455	COG1045	serine acetyltransferase
GPW74_RS08460	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GPW74_RS08465	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GPW74_RS08470	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPW74_RS08475	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
GPW74_RS08480	COG1053	succinate dehydrogenase
GPW74_RS08485	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GPW74_RS08490	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GPW74_RS08495	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
GPW74_RS08500	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GPW74_RS08505	COG1509	lysine 2,3-aminomutase activity
GPW74_RS08515	COG0459	protein refolding
GPW74_RS08520	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GPW74_RS08545	COG0149	triose-phosphate isomerase activity
GPW74_RS08555	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GPW74_RS08560	COG1575	Belongs to the MenA family. Type 1 subfamily
GPW74_RS08565	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GPW74_RS08570	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GPW74_RS08575	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GPW74_RS08580	COG1609	Transcriptional regulator
GPW74_RS08585	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GPW74_RS08590	COG0254	rRNA binding
GPW74_RS08595	COG0281	malic enzyme
GPW74_RS08600	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
GPW74_RS08605	COG0626	cystathionine gamma-synthase activity
GPW74_RS08610	COG0527	aspartate kinase activity
GPW74_RS08610	COG0460	homoserine dehydrogenase
GPW74_RS08615	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GPW74_RS08620	COG3074	FtsZ-dependent cytokinesis
GPW74_RS08625	COG1494	fructose-1,6-bisphosphatase
GPW74_RS08630	COG0205	6-phosphofructokinase activity
GPW74_RS08635	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GPW74_RS08645	COG0745	RESPONSE REGULATOR receiver
GPW74_RS08650	COG2205	protein histidine kinase activity
GPW74_RS08660	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GPW74_RS08665	COG3030	protein affecting phage T7 exclusion by the F plasmid
GPW74_RS08670	COG3706	GGDEF domain
GPW74_RS08675	COG1027	Aspartate ammonia-lyase
GPW74_RS08680	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GPW74_RS08690	COG4232	protein-disulfide reductase activity
GPW74_RS08700	COG3263	regulation of cellular component size
GPW74_RS08710	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPW74_RS08715	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GPW74_RS08720	COG0194	GDP metabolic process
GPW74_RS08725	COG1758	RNA polymerase activity
GPW74_RS08730	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GPW74_RS08735	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GPW74_RS08740	COG2233	PERMEase
GPW74_RS08750	COG0745	RESPONSE REGULATOR receiver
GPW74_RS08755	COG2199	diguanylate cyclase activity
GPW74_RS08760	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPW74_RS08765	COG2183	response to ionizing radiation
GPW74_RS08775	COG0596	Alpha beta hydrolase
GPW74_RS08780	COG1040	competence protein
GPW74_RS08785	COG0316	Belongs to the HesB IscA family
GPW74_RS08785	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GPW74_RS08790	COG0494	nUDIX hydrolase
GPW74_RS08795	COG1218	3'(2'),5'-bisphosphate nucleotidase
GPW74_RS08805	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GPW74_RS08810	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
GPW74_RS08815	COG3156	type II secretion system protein K
GPW74_RS08820	COG4795	General secretion pathway protein
GPW74_RS08825	COG2165	general secretion pathway protein
GPW74_RS08830	COG2165	general secretion pathway protein
GPW74_RS08835	COG2165	general secretion pathway protein
GPW74_RS08840	COG1459	type II secretion system
GPW74_RS08845	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPW74_RS08855	COG3031	protein transport across the cell outer membrane
GPW74_RS08860	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GPW74_RS08865	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GPW74_RS08870	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GPW74_RS08880	COG0456	acetyltransferase
GPW74_RS08885	COG1490	D-aminoacyl-tRNA deacylase activity
GPW74_RS08895	COG1660	Displays ATPase and GTPase activities
GPW74_RS08910	COG0174	glutamine synthetase
GPW74_RS08920	COG3852	Histidine kinase
GPW74_RS08930	COG5001	Diguanylate cyclase
GPW74_RS08930	COG3300	MHYT domain
GPW74_RS08935	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GPW74_RS09000	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GPW74_RS09005	COG1404	Belongs to the peptidase S8 family
GPW74_RS09010	COG4206	TonB-dependent receptor
GPW74_RS09015	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPW74_RS09030	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPW74_RS09035	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPW74_RS09040	COG2177	Part of the ABC transporter FtsEX involved in
GPW74_RS09045	COG2884	Cell division ATP-binding protein ftsE
GPW74_RS09050	COG0552	protein localization to endoplasmic reticulum
GPW74_RS09055	COG0742	ribosomal rna small subunit methyltransferase
GPW74_RS09080	COG0783	Belongs to the Dps family
GPW74_RS09085	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GPW74_RS09090	COG1280	lysine exporter protein (LysE YggA)
GPW74_RS09095	COG2267	carboxylic ester hydrolase activity
GPW74_RS09100	COG0561	phosphatase activity
GPW74_RS09115	COG2200	EAL domain
GPW74_RS09115	COG3287	FIST C domain
GPW74_RS09115	COG2199	diguanylate cyclase activity
GPW74_RS09120	COG1011	Hydrolase
GPW74_RS09125	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GPW74_RS09135	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GPW74_RS09140	COG0019	diaminopimelate decarboxylase activity
GPW74_RS09150	COG1965	Belongs to the frataxin family
GPW74_RS09155	COG3072	Adenylate cyclase
GPW74_RS09165	COG0181	hydroxymethylbilane synthase activity
GPW74_RS09170	COG1587	Uroporphyrinogen-III synthase
GPW74_RS09180	COG3071	HemY protein
GPW74_RS09185	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GPW74_RS09195	COG3078	GTPase activator activity
GPW74_RS09210	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GPW74_RS09215	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPW74_RS09215	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GPW74_RS09235	COG0084	hydrolase, TatD family'
GPW74_RS09240	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GPW74_RS09250	COG0840	transmembrane signaling receptor activity
GPW74_RS09255	COG1580	Controls the rotational direction of flagella during chemotaxis
GPW74_RS09265	COG3161	chorismate lyase activity
GPW74_RS09270	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GPW74_RS09275	COG2937	Belongs to the GPAT DAPAT family
GPW74_RS09280	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GPW74_RS09290	COG0534	Mate efflux family protein
GPW74_RS09295	COG1858	cytochrome C peroxidase
GPW74_RS09300	COG0805	protein transport
GPW74_RS09305	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GPW74_RS09310	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GPW74_RS09315	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GPW74_RS09325	COG2226	methyltransferase
GPW74_RS09330	COG1322	Protein conserved in bacteria
GPW74_RS09340	COG2081	HI0933 family
GPW74_RS09350	COG1528	Iron-storage protein
GPW74_RS09360	COG0589	response to stress
GPW74_RS09365	COG0697	spore germination
GPW74_RS09375	COG0742	ribosomal rna small subunit methyltransferase
GPW74_RS09380	COG5001	Diguanylate cyclase
GPW74_RS09380	COG5002	protein histidine kinase activity
GPW74_RS09385	COG1522	sequence-specific DNA binding
GPW74_RS09405	COG0006	proline dipeptidase activity
GPW74_RS09405	COG0006	proline dipeptidase activity
GPW74_RS09410	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GPW74_RS09415	COG2022	thiamine diphosphate biosynthetic process
GPW74_RS09420	COG2104	thiamine diphosphate biosynthetic process
GPW74_RS09425	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GPW74_RS09435	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GPW74_RS09440	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GPW74_RS09480	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GPW74_RS09490	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GPW74_RS09495	COG0408	coproporphyrinogen oxidase activity
GPW74_RS09500	COG0009	L-threonylcarbamoyladenylate synthase
GPW74_RS09505	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GPW74_RS09510	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GPW74_RS09515	COG0551	DNA topoisomerase type I activity
GPW74_RS09520	COG2922	Belongs to the Smg family
GPW74_RS09525	COG0758	DNA mediated transformation
GPW74_RS09530	COG1652	LysM domain
GPW74_RS09535	COG0242	peptide deformylase activity
GPW74_RS09540	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GPW74_RS09545	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GPW74_RS09545	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GPW74_RS09550	COG0569	domain protein
GPW74_RS09555	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPW74_RS09565	COG1272	protein, Hemolysin III
GPW74_RS09570	COG4326	sporulation control protein
GPW74_RS09580	COG3084	Protein conserved in bacteria
GPW74_RS09590	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GPW74_RS09595	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GPW74_RS09600	COG0204	Acyl-transferase
GPW74_RS09605	COG0606	chelatase, subunit chli
GPW74_RS09620	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GPW74_RS09625	COG0129	dihydroxy-acid dehydratase activity
GPW74_RS09635	COG0604	alcohol dehydrogenase
GPW74_RS09645	COG0425	Belongs to the sulfur carrier protein TusA family
GPW74_RS09655	COG2119	membrane
GPW74_RS09660	COG0752	glycyl-tRNA synthetase alpha subunit
GPW74_RS09665	COG0751	glycine-tRNA ligase activity
GPW74_RS09670	COG3977	Valine--pyruvate aminotransferase
GPW74_RS09675	COG0071	Belongs to the small heat shock protein (HSP20) family
GPW74_RS09690	COG0187	DNA topoisomerase II activity
GPW74_RS09695	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GPW74_RS09700	COG0592	DNA-directed DNA polymerase activity
GPW74_RS09705	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GPW74_RS09720	COG1126	abc transporter atp-binding protein
GPW74_RS09725	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GPW74_RS09730	COG0594	ribonuclease P activity
GPW74_RS09735	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GPW74_RS09740	COG0706	membrane insertase activity
GPW74_RS09745	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GPW74_RS09750	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GPW74_RS09760	COG0445	tRNA wobble uridine modification
GPW74_RS09765	COG0357	Ribosomal RNA small subunit methyltransferase G
GPW74_RS09770	COG1192	Involved in chromosome partitioning
GPW74_RS09775	COG1475	DNA binding
GPW74_RS09780	COG3312	ion transport
GPW74_RS09785	COG0356	it plays a direct role in the translocation of protons across the membrane
GPW74_RS09795	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GPW74_RS09800	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GPW74_RS09805	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GPW74_RS09810	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GPW74_RS09815	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GPW74_RS09820	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GPW74_RS09830	COG2814	Major facilitator Superfamily
GPW74_RS09835	COG0583	DNA-binding transcription factor activity
GPW74_RS09840	COG0183	Belongs to the thiolase family
GPW74_RS09845	COG1250	3-hydroxyacyl-CoA dehydrogenase
GPW74_RS09845	COG1024	Enoyl-CoA hydratase
GPW74_RS09850	COG1739	Uncharacterized protein family UPF0029
GPW74_RS09855	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GPW74_RS09860	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
GPW74_RS09930	COG0583	DNA-binding transcription factor activity
GPW74_RS09935	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GPW74_RS09940	COG2960	long-chain fatty acid transporting porin activity
GPW74_RS09945	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GPW74_RS09950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GPW74_RS09955	COG1309	transcriptional regulator
GPW74_RS10010	COG0747	negative chemotaxis
GPW74_RS10020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPW74_RS10030	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GPW74_RS10035	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GPW74_RS10045	COG0210	DNA helicase
GPW74_RS10050	COG1280	lysine exporter protein (LysE YggA)
GPW74_RS10060	COG0405	Gamma-glutamyltransferase
GPW74_RS10065	COG2962	Rard protein
GPW74_RS10070	COG0514	ATP-dependent DNA helicase (RecQ)
GPW74_RS10090	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GPW74_RS10095	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPW74_RS10095	COG1263	PTS System
GPW74_RS10100	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPW74_RS10110	COG1561	YicC-like family, N-terminal region
GPW74_RS10115	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GPW74_RS10120	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GPW74_RS10125	COG1560	Kdo2-lipid A biosynthetic process
GPW74_RS10130	COG1560	Kdo2-lipid A biosynthetic process
GPW74_RS10135	COG1309	transcriptional regulator
GPW74_RS10145	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GPW74_RS10160	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GPW74_RS10165	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GPW74_RS10175	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GPW74_RS10180	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GPW74_RS10185	COG0859	PFAM glycosyl transferase family 9
GPW74_RS10190	COG0463	Glycosyl transferase, family 2
GPW74_RS10195	COG0859	PFAM glycosyl transferase family 9
GPW74_RS10225	COG1519	Transferase
GPW74_RS10235	COG0859	PFAM glycosyl transferase family 9
GPW74_RS10260	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GPW74_RS10270	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GPW74_RS10275	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GPW74_RS10285	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GPW74_RS10300	COG2089	acid synthase
GPW74_RS10305	COG1083	cytidylyl-transferase
GPW74_RS10310	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GPW74_RS10330	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GPW74_RS10330	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GPW74_RS10370	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GPW74_RS10380	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GPW74_RS10385	COG0668	transmembrane transport
GPW74_RS10390	COG1573	uracil-dna glycosylase
GPW74_RS10400	COG3068	Protein conserved in bacteria
GPW74_RS10405	COG1253	flavin adenine dinucleotide binding
GPW74_RS10410	COG0776	regulation of translation
GPW74_RS10420	COG0151	Belongs to the GarS family
GPW74_RS10425	COG0138	bifunctional purine biosynthesis protein purh
GPW74_RS10435	COG0789	Transcriptional regulator
GPW74_RS10440	COG3710	Transcriptional regulator
GPW74_RS10445	COG0531	amino acid
GPW74_RS10450	COG1982	Orn Lys Arg decarboxylase major
GPW74_RS10455	COG0840	transmembrane signaling receptor activity
GPW74_RS10475	COG0800	Aldolase
GPW74_RS10485	COG3265	gluconokinase activity
GPW74_RS10490	COG0129	dihydroxy-acid dehydratase activity
GPW74_RS10495	COG0387	Pfam Sodium calcium exchanger
GPW74_RS10505	COG1609	Transcriptional regulator
GPW74_RS10540	COG1857	crispr-associated protein
GPW74_RS10550	COG1518	maintenance of DNA repeat elements
GPW74_RS10555	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GPW74_RS10585	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GPW74_RS10590	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPW74_RS10595	COG2264	protein methyltransferase activity
GPW74_RS10600	COG0439	Biotin carboxylase
GPW74_RS10605	COG0511	ligase activity, forming carbon-carbon bonds
GPW74_RS10610	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GPW74_RS10615	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPW74_RS10635	COG2814	Major facilitator Superfamily
GPW74_RS10640	COG2205	protein histidine kinase activity
GPW74_RS10640	COG0784	Response regulator, receiver
GPW74_RS10645	COG0248	Ppx GppA phosphatase
GPW74_RS10650	COG0513	Belongs to the DEAD box helicase family
GPW74_RS10655	COG3118	belongs to the thioredoxin family
GPW74_RS10660	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GPW74_RS10670	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GPW74_RS10750	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GPW74_RS10760	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GPW74_RS10770	COG1072	(Pantothenic acid kinase))
GPW74_RS10795	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GPW74_RS10800	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GPW74_RS10805	COG0250	Participates in transcription elongation, termination and antitermination
GPW74_RS10810	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GPW74_RS10815	COG0081	regulation of translation
GPW74_RS10820	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GPW74_RS10825	COG0222	ribosome binding
GPW74_RS10830	COG0085	RNA polymerase activity
GPW74_RS10835	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GPW74_RS10840	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
GPW74_RS10845	COG2816	NAD+ diphosphatase activity
GPW74_RS10850	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GPW74_RS10865	COG4942	peptidase
GPW74_RS10870	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GPW74_RS10880	COG0471	metal ion transport
GPW74_RS10885	COG0688	phosphatidylethanolamine metabolic process
GPW74_RS10890	COG1162	GTPase activity
GPW74_RS10895	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GPW74_RS10950	COG0802	atpase or kinase
GPW74_RS10960	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GPW74_RS10965	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GPW74_RS10970	COG1923	regulation of RNA biosynthetic process
GPW74_RS10975	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GPW74_RS10980	COG0330	HflC and HflK could
GPW74_RS10985	COG0330	HflC and HflK could
GPW74_RS10990	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
GPW74_RS10995	COG2900	Belongs to the SlyX family
GPW74_RS11005	COG0545	Peptidyl-prolyl cis-trans isomerase
GPW74_RS11010	COG2964	Protein conserved in bacteria
GPW74_RS11015	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GPW74_RS11020	COG2923	Belongs to the DsrF TusC family
GPW74_RS11030	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GPW74_RS11035	COG0049	tRNA binding
GPW74_RS11040	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GPW74_RS11045	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GPW74_RS11050	COG2906	2 iron, 2 sulfur cluster binding
GPW74_RS11060	COG0360	Binds together with S18 to 16S ribosomal RNA
GPW74_RS11065	COG2965	DNA replication, synthesis of RNA primer
GPW74_RS11070	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GPW74_RS11075	COG0359	binds to the 23S rRNA
GPW74_RS11085	COG0305	Participates in initiation and elongation during chromosome replication
GPW74_RS11090	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GPW74_RS11095	COG0432	Pfam Uncharacterised protein family UPF0047
GPW74_RS11100	COG0166	Belongs to the GPI family
GPW74_RS11115	COG0735	belongs to the Fur family
GPW74_RS11120	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GPW74_RS11150	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GPW74_RS11155	COG0175	sulfate reduction
GPW74_RS11195	COG0646	methionine synthase
GPW74_RS11195	COG1410	methionine synthase
GPW74_RS11200	COG0527	aspartate kinase activity
GPW74_RS11205	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GPW74_RS11215	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GPW74_RS11230	COG0629	single-stranded DNA binding
GPW74_RS11260	COG3409	Peptidoglycan-binding domain 1 protein
GPW74_RS11260	COG3267	Type II secretory pathway component ExeA
GPW74_RS11270	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GPW74_RS11275	COG1459	type II secretion system
GPW74_RS11320	COG1077	Cell shape determining protein MreB Mrl
GPW74_RS11325	COG1792	Involved in formation and maintenance of cell shape
GPW74_RS11330	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GPW74_RS11335	COG0424	maF-like protein
GPW74_RS11340	COG1530	ribonuclease E activity
GPW74_RS11345	COG3164	Protein of unknown function
GPW74_RS11350	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GPW74_RS11355	COG0312	modulator of DNA gyrase
GPW74_RS11360	COG2235	arginine
GPW74_RS11380	COG0589	response to stress
GPW74_RS11395	COG1438	arginine binding
GPW74_RS11400	COG0039	L-malate dehydrogenase activity
GPW74_RS11405	COG0531	amino acid
GPW74_RS11410	COG0142	geranyltranstransferase activity
GPW74_RS11415	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GPW74_RS11420	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GPW74_RS11425	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GPW74_RS11430	COG2966	Psort location CytoplasmicMembrane, score
GPW74_RS11435	COG3610	response to peptide
GPW74_RS11445	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GPW74_RS11450	COG2967	ApaG domain
GPW74_RS11455	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GPW74_RS11460	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GPW74_RS11465	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPW74_RS11470	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GPW74_RS11475	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GPW74_RS11505	COG0840	transmembrane signaling receptor activity
GPW74_RS11530	COG0741	lytic transglycosylase activity
GPW74_RS11535	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
GPW74_RS11540	COG1194	a g-specific adenine glycosylase
GPW74_RS11545	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GPW74_RS11550	COG2066	Belongs to the glutaminase family
GPW74_RS11555	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GPW74_RS11560	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GPW74_RS11575	COG0762	integral membrane protein
GPW74_RS11580	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GPW74_RS11585	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GPW74_RS11605	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GPW74_RS11610	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GPW74_RS11615	COG1678	Uncharacterized ACR, COG1678
GPW74_RS11620	COG0189	ligase activity
GPW74_RS11625	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GPW74_RS11630	COG2356	endonuclease I
GPW74_RS11635	COG3091	SprT-like family
GPW74_RS11640	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GPW74_RS11645	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GPW74_RS11650	COG0583	DNA-binding transcription factor activity
GPW74_RS11655	COG4771	TonB-dependent receptor
GPW74_RS11660	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GPW74_RS11665	COG0126	phosphoglycerate kinase activity
GPW74_RS11670	COG0191	fructose-bisphosphate aldolase activity
GPW74_RS11675	COG0668	transmembrane transport
GPW74_RS11680	COG1279	arginine transmembrane transporter activity
GPW74_RS11685	COG0583	DNA-binding transcription factor activity
GPW74_RS11695	COG0469	pyruvate kinase activity
GPW74_RS11700	COG1349	DNA-binding transcription factor activity
GPW74_RS11705	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GPW74_RS11710	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GPW74_RS11725	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPW74_RS11730	COG0358	DNA primase activity
GPW74_RS11735	COG1610	YqeY-like protein
GPW74_RS11740	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GPW74_RS11745	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GPW74_RS11755	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GPW74_RS11760	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GPW74_RS11765	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GPW74_RS11770	COG1968	undecaprenyl-diphosphatase activity
GPW74_RS11775	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GPW74_RS11780	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GPW74_RS11785	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GPW74_RS11790	COG0585	pseudouridine synthase activity
GPW74_RS11795	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GPW74_RS11800	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GPW74_RS11805	COG1388	LysM domain
GPW74_RS11805	COG4942	peptidase
GPW74_RS11810	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GPW74_RS11815	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GPW74_RS11835	COG4208	sulfate ABC transporter
GPW74_RS11840	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GPW74_RS11850	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GPW74_RS11855	COG2137	regulation of response to DNA damage stimulus
GPW74_RS11860	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GPW74_RS11865	COG0527	aspartate kinase activity
GPW74_RS11870	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GPW74_RS11915	COG3630	sodium ion export across plasma membrane
GPW74_RS11920	COG5016	pyruvate
GPW74_RS11920	COG0511	ligase activity, forming carbon-carbon bonds
GPW74_RS11925	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GPW74_RS11935	COG1238	metal cluster binding
GPW74_RS11940	COG0612	Peptidase, M16
GPW74_RS11945	COG2918	glutathione biosynthetic process
GPW74_RS11955	COG4536	flavin adenine dinucleotide binding
GPW74_RS11960	COG4137	Cytochrome C assembly protein
GPW74_RS11965	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GPW74_RS11970	COG0228	four-way junction DNA binding
GPW74_RS11975	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GPW74_RS11980	COG0336	Belongs to the RNA methyltransferase TrmD family
GPW74_RS11985	COG0335	large ribosomal subunit rRNA binding
GPW74_RS11990	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GPW74_RS11995	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GPW74_RS12005	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GPW74_RS12010	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GPW74_RS12015	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GPW74_RS12020	COG0723	plastoquinol--plastocyanin reductase activity
GPW74_RS12030	COG2857	Cytochrome c1
GPW74_RS12035	COG0625	glutathione transferase activity
GPW74_RS12040	COG2969	positive regulation of protein catabolic process
GPW74_RS12045	COG2823	Periplasmic or secreted lipoprotein
GPW74_RS12050	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
GPW74_RS12055	COG0792	nuclease activity
GPW74_RS12060	COG3107	peptidoglycan biosynthetic process
GPW74_RS12065	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GPW74_RS12080	COG0288	reversible hydration of carbon dioxide
GPW74_RS12085	COG0659	secondary active sulfate transmembrane transporter activity
GPW74_RS12090	COG1131	(ABC) transporter
GPW74_RS12095	COG0842	Transport permease protein
GPW74_RS12100	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GPW74_RS12105	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GPW74_RS12110	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GPW74_RS12120	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GPW74_RS12125	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GPW74_RS12130	COG1489	DNA binding
GPW74_RS12140	COG1643	Atp-dependent helicase
GPW74_RS12145	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GPW74_RS12160	COG3112	Uncharacterised protein family (UPF0231)
GPW74_RS12165	COG0347	Belongs to the P(II) protein family
GPW74_RS12170	COG0004	ammonium transporteR
GPW74_RS12175	COG1840	ABC-type Fe3 transport system, periplasmic component
GPW74_RS12185	COG3842	ATPase activity
GPW74_RS12205	COG2971	BadF BadG BcrA BcrD
GPW74_RS12215	COG4608	Belongs to the ABC transporter superfamily
GPW74_RS12220	COG0444	Belongs to the ABC transporter superfamily
GPW74_RS12225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPW74_RS12230	COG0601	transmembrane transport
GPW74_RS12235	COG0747	negative chemotaxis
GPW74_RS12245	COG2813	Specifically methylates the guanine in position
GPW74_RS12250	COG0628	permease
GPW74_RS12260	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GPW74_RS12265	COG0316	Belongs to the HesB IscA family
GPW74_RS12280	COG0739	heme binding
GPW74_RS12285	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GPW74_RS12290	COG2027	D-alanyl-D-alanine carboxypeptidase
GPW74_RS12295	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPW74_RS12300	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPW74_RS12305	COG1534	Rna-binding protein
GPW74_RS12310	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GPW74_RS12315	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GPW74_RS12320	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GPW74_RS12325	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPW74_RS12330	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GPW74_RS12345	COG0779	Required for maturation of 30S ribosomal subunits
GPW74_RS12350	COG0195	Participates in both transcription termination and antitermination
GPW74_RS12355	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GPW74_RS12360	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GPW74_RS12365	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GPW74_RS12370	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GPW74_RS12375	COG1185	polyribonucleotide nucleotidyltransferase activity
GPW74_RS12380	COG4785	May be involved in cell division
GPW74_RS12415	COG3153	acetyltransferase
GPW74_RS12435	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GPW74_RS12440	COG0513	Belongs to the DEAD box helicase family
GPW74_RS12445	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GPW74_RS12460	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GPW74_RS12465	COG2204	response regulator
GPW74_RS12480	COG0667	Aldo Keto reductase
GPW74_RS12485	COG3066	DNA modification
GPW74_RS12490	COG0494	nUDIX hydrolase
GPW74_RS12495	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
GPW74_RS12500	COG0730	response to heat
GPW74_RS12505	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GPW74_RS12510	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GPW74_RS12515	COG1283	sodium-dependent phosphate transmembrane transporter activity
GPW74_RS12520	COG0583	DNA-binding transcription factor activity
GPW74_RS12525	COG0640	Transcriptional regulator
GPW74_RS12530	COG0268	Binds directly to 16S ribosomal RNA
GPW74_RS12535	COG0728	peptidoglycan biosynthetic process
GPW74_RS12540	COG0196	riboflavin kinase activity
GPW74_RS12545	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GPW74_RS12550	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GPW74_RS12555	COG1047	Peptidyl-prolyl cis-trans
GPW74_RS12560	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GPW74_RS12565	COG1966	Carbon starvation protein
GPW74_RS12575	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GPW74_RS12580	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GPW74_RS12585	COG1472	Belongs to the glycosyl hydrolase 3 family
GPW74_RS12590	COG3279	Response regulator of the LytR AlgR family
GPW74_RS12595	COG3275	phosphorelay sensor kinase activity
GPW74_RS12600	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPW74_RS12605	COG0287	Prephenate dehydrogenase
GPW74_RS12605	COG1605	Chorismate mutase
GPW74_RS12615	COG0488	(ABC) transporter
GPW74_RS12625	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
GPW74_RS12630	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
GPW74_RS12635	COG5001	Diguanylate cyclase
GPW74_RS12640	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPW74_RS12645	COG1605	Chorismate mutase
GPW74_RS12645	COG0077	Prephenate dehydratase
GPW74_RS12650	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GPW74_RS12655	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPW74_RS12660	COG0564	pseudouridine synthase activity
GPW74_RS12670	COG0542	response to heat
GPW74_RS12715	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GPW74_RS12725	COG2974	May be involved in recombination
GPW74_RS12730	COG0745	RESPONSE REGULATOR receiver
GPW74_RS12735	COG5002	protein histidine kinase activity
GPW74_RS12745	COG0248	Ppx GppA phosphatase
GPW74_RS12750	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GPW74_RS12760	COG0581	inorganic phosphate transmembrane transporter activity
GPW74_RS12765	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GPW74_RS12780	COG3142	Participates in the control of copper homeostasis
GPW74_RS12785	COG0450	alkyl hydroperoxide reductase
GPW74_RS12790	COG0583	DNA-binding transcription factor activity
GPW74_RS12795	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GPW74_RS12805	COG0517	IMP dehydrogenase activity
GPW74_RS12810	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GPW74_RS12815	COG0343	queuine tRNA-ribosyltransferase activity
GPW74_RS12820	COG1862	Preprotein translocase
GPW74_RS12825	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPW74_RS12830	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPW74_RS12835	COG0483	inositol monophosphate 1-phosphatase activity
GPW74_RS12845	COG1959	2 iron, 2 sulfur cluster binding
GPW74_RS12850	COG1104	cysteine desulfurase activity
GPW74_RS12855	COG0822	iron-sulfur transferase activity
GPW74_RS12875	COG0633	Ferredoxin
GPW74_RS12880	COG2975	iron-sulfur cluster assembly
GPW74_RS12885	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GPW74_RS12890	COG0105	UTP biosynthetic process
GPW74_RS12905	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GPW74_RS12910	COG0124	histidyl-tRNA synthetase
GPW74_RS12915	COG2976	Protein conserved in bacteria
GPW74_RS12920	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GPW74_RS12925	COG1160	GTP binding
GPW74_RS12940	COG1570	exodeoxyribonuclease VII activity
GPW74_RS12945	COG0516	GMP reductase activity
GPW74_RS12945	COG0517	IMP dehydrogenase activity
GPW74_RS12950	COG0519	Catalyzes the synthesis of GMP from XMP
GPW74_RS12950	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GPW74_RS12960	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GPW74_RS12965	COG0210	DNA helicase
GPW74_RS13045	COG3023	N-Acetylmuramoyl-L-alanine amidase
GPW74_RS13055	COG1584	GPR1 FUN34 yaaH family protein
GPW74_RS13060	COG3433	isochorismatase activity
GPW74_RS13060	COG1535	isochorismatase
GPW74_RS13065	COG1021	2,3-dihydroxybenzoate-AMP ligase
GPW74_RS13070	COG1169	isochorismate synthase
GPW74_RS13075	COG1028	Short-chain dehydrogenase reductase Sdr
GPW74_RS13085	COG4592	Periplasmic binding protein
GPW74_RS13090	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPW74_RS13095	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPW74_RS13100	COG1120	ATPase activity
GPW74_RS13110	COG0583	DNA-binding transcription factor activity
GPW74_RS13115	COG2015	COG2015, Alkyl sulfatase and related hydrolases
GPW74_RS13120	COG1115	amino acid carrier protein
GPW74_RS13125	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GPW74_RS13145	COG4565	transcriptional regulatory protein
GPW74_RS13155	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GPW74_RS13160	COG5016	pyruvate
GPW74_RS13160	COG0511	ligase activity, forming carbon-carbon bonds
GPW74_RS13165	COG3630	sodium ion export across plasma membrane
GPW74_RS13175	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
GPW74_RS13180	COG3052	prosthetic group binding
GPW74_RS13185	COG4412	M6 family metalloprotease domain protein
GPW74_RS13185	COG3291	Pkd domain containing protein
GPW74_RS13190	COG5380	lipid catabolic process
GPW74_RS13195	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GPW74_RS13200	COG0840	transmembrane signaling receptor activity
GPW74_RS13210	COG3240	lipase activity
GPW74_RS13225	COG2814	Major facilitator Superfamily
GPW74_RS13230	COG1757	Na H antiporter
GPW74_RS13250	COG0784	Response regulator, receiver
GPW74_RS13250	COG3437	response regulator, receiver
GPW74_RS13260	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GPW74_RS13265	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GPW74_RS13270	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GPW74_RS13275	COG0513	Belongs to the DEAD box helicase family
GPW74_RS13285	COG0516	GMP reductase activity
GPW74_RS13295	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GPW74_RS13305	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GPW74_RS13335	COG3036	rescue of stalled ribosome
GPW74_RS13340	COG1278	Cold shock
GPW74_RS13345	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPW74_RS13345	COG1017	nitric oxide dioxygenase activity
GPW74_RS13350	COG3604	Transcriptional regulator
GPW74_RS13360	COG2195	Cleaves the N-terminal amino acid of tripeptides
GPW74_RS13365	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GPW74_RS13380	COG0840	transmembrane signaling receptor activity
GPW74_RS13385	COG0714	Associated with various cellular activities
GPW74_RS13405	COG2304	oxidoreductase activity
GPW74_RS13420	COG1278	Cold shock
GPW74_RS13425	COG5001	Diguanylate cyclase
GPW74_RS13425	COG5002	protein histidine kinase activity
GPW74_RS13435	COG3530	Putative quorum-sensing-regulated virulence factor
GPW74_RS13450	COG3033	Beta-eliminating lyase
GPW74_RS13455	COG0814	amino acid
GPW74_RS13460	COG0589	response to stress
GPW74_RS13470	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GPW74_RS13470	COG2111	Na H antiporter
GPW74_RS13490	COG2212	antiporter activity
GPW74_RS13495	COG1320	monovalent cation:proton antiporter activity
GPW74_RS13500	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GPW74_RS13500	COG1017	nitric oxide dioxygenase activity
GPW74_RS13505	COG1609	Transcriptional regulator
GPW74_RS13510	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPW74_RS13525	COG0242	peptide deformylase activity
GPW74_RS13575	COG2271	Major facilitator Superfamily
GPW74_RS13580	COG0584	glycerophosphoryl diester phosphodiesterase
GPW74_RS13590	COG5001	Diguanylate cyclase
GPW74_RS13590	COG5002	protein histidine kinase activity
GPW74_RS13590	COG3447	MASE1 domain protein
GPW74_RS13595	COG1609	Transcriptional regulator
GPW74_RS13600	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPW74_RS13605	COG1879	ABC-type sugar transport system periplasmic component
GPW74_RS13615	COG1129	ABC transporter
GPW74_RS13620	COG1869	D-ribose catabolic process
GPW74_RS13730	COG0564	pseudouridine synthase activity
GPW74_RS13740	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPW74_RS13745	COG2200	EAL domain
GPW74_RS13745	COG2771	luxR family
GPW74_RS13755	COG0673	inositol 2-dehydrogenase activity
GPW74_RS13760	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GPW74_RS13795	COG1342	Belongs to the UPF0251 family
GPW74_RS13810	COG1301	dicarboxylic acid transport
GPW74_RS13835	COG2814	Major facilitator Superfamily
GPW74_RS13840	COG0583	DNA-binding transcription factor activity
GPW74_RS13845	COG3300	MHYT domain
GPW74_RS13845	COG5001	Diguanylate cyclase
GPW74_RS13850	COG0739	heme binding
GPW74_RS13860	COG0659	secondary active sulfate transmembrane transporter activity
GPW74_RS13880	COG0745	RESPONSE REGULATOR receiver
GPW74_RS13880	COG3706	GGDEF domain
GPW74_RS13885	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GPW74_RS13890	COG0581	inorganic phosphate transmembrane transporter activity
GPW74_RS13895	COG0573	inorganic phosphate transmembrane transporter activity
GPW74_RS13900	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GPW74_RS13925	COG1770	oligopeptidase
GPW74_RS13930	COG0513	Belongs to the DEAD box helicase family
GPW74_RS13940	COG1388	LysM domain
GPW74_RS13940	COG1376	ErfK ybiS ycfS ynhG family protein
GPW74_RS13945	COG0415	Belongs to the DNA photolyase family
GPW74_RS13955	COG3272	Protein of unknown function (DUF1722)
GPW74_RS13960	COG0813	purine-nucleoside phosphorylase activity
GPW74_RS13975	COG3706	GGDEF domain
GPW74_RS13985	COG1566	PFAM secretion protein HlyD family protein
GPW74_RS14005	COG0786	glutamate:sodium symporter activity
GPW74_RS14020	COG1999	signal sequence binding
GPW74_RS14030	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
GPW74_RS14040	COG0671	phosphoesterase, PA-phosphatase related
GPW74_RS14075	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GPW74_RS14080	COG0471	metal ion transport
GPW74_RS14115	COG3501	Rhs element vgr protein
GPW74_RS14125	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GPW74_RS14130	COG1640	4-alpha-glucanotransferase
GPW74_RS14135	COG0058	SHG alpha-glucan phosphorylase activity
GPW74_RS14140	COG2909	trisaccharide binding
GPW74_RS14160	COG2084	Dehydrogenase
GPW74_RS14165	COG0217	transcriptional regulatory protein
GPW74_RS14200	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GPW74_RS14205	COG1444	tRNA N-acetyltransferase activity
GPW74_RS14225	COG4221	oxidoreductase activity
GPW74_RS14235	COG0745	RESPONSE REGULATOR receiver
GPW74_RS14240	COG0642	Histidine kinase
GPW74_RS14245	COG2194	sulfuric ester hydrolase activity
GPW74_RS14250	COG4608	Belongs to the ABC transporter superfamily
GPW74_RS14255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GPW74_RS14260	COG0601	transmembrane transport
GPW74_RS14280	COG2198	Histidine kinase
GPW74_RS14280	COG0643	Histidine kinase
GPW74_RS14285	COG0835	chemotaxis
GPW74_RS14290	COG0835	chemotaxis
GPW74_RS14295	COG0840	transmembrane signaling receptor activity
GPW74_RS14300	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GPW74_RS14305	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
GPW74_RS14355	COG0259	pyridoxamine-phosphate oxidase activity
GPW74_RS14365	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GPW74_RS14390	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GPW74_RS14420	COG1982	Orn Lys Arg decarboxylase major
GPW74_RS14425	COG0531	amino acid
GPW74_RS14435	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GPW74_RS14440	COG1901	pseudouridine methyltransferase
GPW74_RS14450	COG4221	oxidoreductase activity
GPW74_RS14455	COG0840	transmembrane signaling receptor activity
GPW74_RS14465	COG2910	NAD(P)H-binding
GPW74_RS14495	COG0673	inositol 2-dehydrogenase activity
GPW74_RS14500	COG3722	fumarate hydratase activity
GPW74_RS14505	COG0246	Mannitol dehydrogenase
GPW74_RS14510	COG2213	PTS system mannitol-specific
GPW74_RS14510	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPW74_RS14515	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GPW74_RS14520	COG4597	amino acid ABC transporter
GPW74_RS14525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPW74_RS14535	COG1126	abc transporter atp-binding protein
GPW74_RS14540	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GPW74_RS14550	COG3706	GGDEF domain
GPW74_RS14555	COG0840	transmembrane signaling receptor activity
GPW74_RS14570	COG0840	transmembrane signaling receptor activity
GPW74_RS14585	COG4580	involved in the transport of maltose and maltodextrins
GPW74_RS14600	COG0363	glucosamine-6-phosphate deaminase activity
GPW74_RS14625	COG2259	Doxx family
GPW74_RS14630	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GPW74_RS14635	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GPW74_RS14645	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GPW74_RS14650	COG3366	ferrous iron transmembrane transporter activity
GPW74_RS14655	COG0700	Nucleoside recognition
GPW74_RS14665	COG0697	spore germination
GPW74_RS14670	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
GPW74_RS14675	COG1764	response to oxidative stress
GPW74_RS14680	COG1846	Transcriptional regulator
GPW74_RS14700	COG2207	Transcriptional regulator
GPW74_RS14705	COG1280	lysine exporter protein (LysE YggA)
GPW74_RS14715	COG1902	pentaerythritol trinitrate reductase activity
GPW74_RS14725	COG1132	(ABC) transporter
GPW74_RS14735	COG0513	Belongs to the DEAD box helicase family
GPW74_RS14740	COG2258	MOSC domain
GPW74_RS14760	COG0840	transmembrane signaling receptor activity
GPW74_RS14770	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GPW74_RS14780	COG1304	FMN binding
GPW74_RS14785	COG1620	l-lactate permease
GPW74_RS14790	COG0583	DNA-binding transcription factor activity
GPW74_RS14810	COG4172	Belongs to the ABC transporter superfamily
GPW74_RS14820	COG1067	ATP-dependent peptidase activity
GPW74_RS14835	COG2211	Major facilitator Superfamily
GPW74_RS14845	COG3123	guanosine phosphorylase activity
GPW74_RS14850	COG1741	Belongs to the pirin family
GPW74_RS14860	COG5001	Diguanylate cyclase
GPW74_RS14865	COG0583	DNA-binding transcription factor activity
GPW74_RS14900	COG3706	GGDEF domain
GPW74_RS14905	COG1846	Transcriptional regulator
GPW74_RS14915	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GPW74_RS14920	COG2197	response regulator
GPW74_RS14925	COG0393	Putative heavy-metal-binding
GPW74_RS14940	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPW74_RS14945	COG3842	ATPase activity
GPW74_RS14955	COG1175	transmembrane transport
GPW74_RS14960	COG3833	ABC-type maltose transport systems, permease component
GPW74_RS14975	COG1349	DNA-binding transcription factor activity
GPW74_RS14980	COG3706	GGDEF domain
GPW74_RS15005	COG1278	Cold shock
GPW74_RS15010	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GPW74_RS15015	COG2354	Protein conserved in bacteria
GPW74_RS15020	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GPW74_RS15030	COG3152	Membrane
GPW74_RS15040	COG0418	dihydroorotase activity
GPW74_RS15045	COG0633	Ferredoxin
GPW74_RS15045	COG3217	Mosc domain protein beta barrel domain protein
GPW74_RS15045	COG0633	Ferredoxin
GPW74_RS15045	COG3217	Mosc domain protein beta barrel domain protein
GPW74_RS15080	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GPW74_RS15085	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GPW74_RS15095	COG0848	biopolymer transport protein
GPW74_RS15100	COG0811	peptide transport
GPW74_RS15105	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GPW74_RS15115	COG3721	Heme iron utilization protein
GPW74_RS15120	COG0748	coenzyme F420 binding
GPW74_RS15155	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GPW74_RS15160	COG0363	glucosamine-6-phosphate deaminase activity
GPW74_RS15165	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GPW74_RS15170	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GPW74_RS15175	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GPW74_RS15195	COG0346	lactoylglutathione lyase activity
GPW74_RS15210	COG0693	protein deglycase activity
GPW74_RS15215	COG0156	8-amino-7-oxononanoate synthase activity
GPW74_RS15220	COG1063	alcohol dehydrogenase
GPW74_RS15235	COG0582	viral genome integration into host DNA
GPW74_RS15260	COG4626	Terminase
GPW74_RS15260	COG1802	Transcriptional regulator
GPW74_RS15285	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GPW74_RS15290	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GPW74_RS15315	COG0640	Transcriptional regulator
GPW74_RS15320	COG0798	PFAM Bile acid sodium symporter
GPW74_RS15445	COG0840	transmembrane signaling receptor activity
GPW74_RS15480	COG1063	alcohol dehydrogenase
GPW74_RS15490	COG0582	viral genome integration into host DNA
GPW74_RS15495	COG0583	DNA-binding transcription factor activity
GPW74_RS15500	COG3048	D-serine ammonia-lyase activity
GPW74_RS15510	COG1278	Cold shock
GPW74_RS15515	COG0557	exoribonuclease II activity
GPW74_RS15520	COG1686	Belongs to the peptidase S11 family
GPW74_RS15530	COG3047	cAMP biosynthetic process
GPW74_RS15535	COG3227	Zinc metalloprotease (Elastase)
GPW74_RS15545	COG2267	carboxylic ester hydrolase activity
GPW74_RS15550	COG2067	long-chain fatty acid transport protein
GPW74_RS15560	COG0366	Alpha amylase catalytic
GPW74_RS15565	COG4989	oxidoreductase activity
GPW74_RS15580	COG3706	GGDEF domain
GPW74_RS15585	COG0531	amino acid
GPW74_RS15610	COG1765	OsmC-like protein
GPW74_RS15615	COG1253	flavin adenine dinucleotide binding
GPW74_RS15620	COG2171	N-acyltransferase activity
GPW74_RS15635	COG0583	DNA-binding transcription factor activity
GPW74_RS15640	COG2264	protein methyltransferase activity
GPW74_RS15655	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GPW74_RS15660	COG3186	Phenylalanine-4-hydroxylase
GPW74_RS15665	COG2154	pterin-4-alpha-carbinolamine dehydratase
GPW74_RS15670	COG0527	aspartate kinase activity
GPW74_RS15680	COG0459	protein refolding
GPW74_RS15685	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GPW74_RS15690	COG2239	Acts as a magnesium transporter
GPW74_RS15705	COG1166	arginine decarboxylase activity
GPW74_RS15710	COG0010	Belongs to the arginase family
GPW74_RS15725	COG3397	chitin binding
GPW74_RS15730	COG3046	protein related to deoxyribodipyrimidine photolyase
GPW74_RS15740	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GPW74_RS15750	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
GPW74_RS15755	COG0513	Belongs to the DEAD box helicase family
GPW74_RS15765	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GPW74_RS15780	COG0546	phosphoglycolate phosphatase activity
GPW74_RS15795	COG0484	heat shock protein binding
GPW74_RS15810	COG5001	Diguanylate cyclase
GPW74_RS15810	COG1716	ATPase activity
GPW74_RS15815	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GPW74_RS15825	COG4181	ATPase activity
GPW74_RS15830	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GPW74_RS15845	COG1984	allophanate hydrolase subunit 2
GPW74_RS15855	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GPW74_RS15860	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GPW74_RS15865	COG0840	transmembrane signaling receptor activity
GPW74_RS15870	COG0814	amino acid
GPW74_RS15880	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
GPW74_RS15885	COG0513	Belongs to the DEAD box helicase family
GPW74_RS15890	COG1309	transcriptional regulator
GPW74_RS15900	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
GPW74_RS15905	COG0494	nUDIX hydrolase
GPW74_RS15915	COG2425	protein containing a von Willebrand factor type A (vWA) domain
GPW74_RS15925	COG1126	abc transporter atp-binding protein
GPW74_RS15930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GPW74_RS15935	COG4215	(ABC) transporter
GPW74_RS15940	COG4160	amino acid transport
GPW74_RS15965	COG3118	belongs to the thioredoxin family
GPW74_RS15970	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GPW74_RS15975	COG0247	lactate metabolic process
GPW74_RS15980	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
GPW74_RS15985	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GPW74_RS15990	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GPW74_RS15995	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GPW74_RS16020	COG3132	Protein of unknown function, DUF480
GPW74_RS16025	COG2827	Endonuclease containing a URI domain
GPW74_RS16035	COG1879	ABC-type sugar transport system periplasmic component
GPW74_RS16040	COG5002	protein histidine kinase activity
GPW74_RS16040	COG0784	Response regulator, receiver
GPW74_RS16050	COG1132	(ABC) transporter
GPW74_RS16055	COG1132	(ABC) transporter
GPW74_RS16075	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GPW74_RS16080	COG1021	2,3-dihydroxybenzoate-AMP ligase
GPW74_RS16105	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GPW74_RS16105	COG2226	methyltransferase
GPW74_RS16105	COG3433	isochorismatase activity
GPW74_RS16110	COG2814	Major facilitator Superfamily
GPW74_RS16160	COG1492	cobalamin metabolic process
GPW74_RS16165	COG0725	ABC transporter, periplasmic molybdate-binding protein
GPW74_RS16170	COG4149	molybdate abc transporter
GPW74_RS16175	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GPW74_RS16205	COG1289	transmembrane transporter activity
GPW74_RS16210	COG0210	DNA helicase
GPW74_RS16215	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GPW74_RS16220	COG1335	isochorismatase
GPW74_RS16225	COG1803	Methylglyoxal synthase
GPW74_RS16230	COG1879	ABC-type sugar transport system periplasmic component
GPW74_RS16235	COG2198	Histidine kinase
GPW74_RS16235	COG0784	Response regulator, receiver
GPW74_RS16235	COG2205	protein histidine kinase activity
GPW74_RS16240	COG0469	pyruvate kinase activity
GPW74_RS16245	COG2271	Major facilitator Superfamily
GPW74_RS16250	COG1840	ABC-type Fe3 transport system, periplasmic component
GPW74_RS16255	COG4191	Histidine kinase
GPW74_RS16270	COG1979	alcohol dehydrogenase
GPW74_RS16280	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GPW74_RS16285	COG3706	GGDEF domain
GPW74_RS16300	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPW74_RS16305	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GPW74_RS16315	COG0183	Belongs to the thiolase family
GPW74_RS16325	COG3243	poly(R)-hydroxyalkanoic acid synthase
GPW74_RS16330	COG3842	ATPase activity
GPW74_RS16340	COG1840	ABC-type Fe3 transport system, periplasmic component
GPW74_RS16345	COG2271	Major facilitator Superfamily
GPW74_RS16350	COG3851	Histidine kinase
GPW74_RS16355	COG2197	response regulator
GPW74_RS16360	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GPW74_RS16380	COG0243	molybdopterin cofactor binding
GPW74_RS16390	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GPW74_RS16395	COG3850	Histidine kinase
GPW74_RS16400	COG2197	response regulator
GPW74_RS16405	COG1760	l-serine dehydratase
GPW74_RS16410	COG3069	C4-dicarboxylate transmembrane transporter activity
GPW74_RS16415	COG0840	transmembrane signaling receptor activity
GPW74_RS16420	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPW74_RS16430	COG1328	CTP reductase activity
GPW74_RS16435	COG0602	queuosine metabolic process
GPW74_RS16445	COG4067	protein conserved in archaea
GPW74_RS16445	COG0189	ligase activity
GPW74_RS16450	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPW74_RS16450	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
GPW74_RS16450	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GPW74_RS16455	COG1105	Belongs to the carbohydrate kinase PfkB family
GPW74_RS16460	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPW74_RS16460	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GPW74_RS16465	COG1609	Transcriptional regulator
GPW74_RS16470	COG0420	3'-5' exonuclease activity
GPW74_RS16475	COG0419	ATPase involved in DNA repair
GPW74_RS16480	COG0784	Response regulator, receiver
GPW74_RS16480	COG2205	protein histidine kinase activity
GPW74_RS16485	COG0156	8-amino-7-oxononanoate synthase activity
GPW74_RS16500	COG0523	cobalamin synthesis protein
GPW74_RS16510	COG3158	transport of potassium into the cell
GPW74_RS16515	COG1013	pyruvate-flavodoxin oxidoreductase activity
GPW74_RS16515	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GPW74_RS16515	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GPW74_RS16515	COG0674	pyruvate-flavodoxin oxidoreductase activity
GPW74_RS16520	COG2205	protein histidine kinase activity
GPW74_RS16525	COG0745	RESPONSE REGULATOR receiver
GPW74_RS16530	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GPW74_RS16545	COG2200	EAL domain
GPW74_RS16555	COG3038	cytochrome b561
GPW74_RS16565	COG2116	formate transmembrane transporter activity
GPW74_RS16570	COG0583	DNA-binding transcription factor activity
GPW74_RS16580	COG3593	DNA synthesis involved in DNA repair
GPW74_RS16605	COG2824	Alkylphosphonate utilization operon protein PhnA
GPW74_RS16655	COG3706	GGDEF domain
GPW74_RS16670	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GPW74_RS16675	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GPW74_RS16685	COG0745	RESPONSE REGULATOR receiver
GPW74_RS16705	COG0023	Translation Initiation Factor
GPW74_RS16715	COG1181	Belongs to the D-alanine--D-alanine ligase family
GPW74_RS16725	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPW74_RS16725	COG0045	succinate-CoA ligase (ADP-forming) activity
GPW74_RS16725	COG1042	CoA-binding domain protein
GPW74_RS16730	COG0583	DNA-binding transcription factor activity
GPW74_RS16735	COG4771	TonB-dependent receptor
GPW74_RS16750	COG2050	protein possibly involved in aromatic compounds catabolism
GPW74_RS16770	COG0625	glutathione transferase activity
GPW74_RS16785	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GPW74_RS16790	COG4172	Belongs to the ABC transporter superfamily
GPW74_RS16795	COG4239	(ABC) transporter, permease
GPW74_RS16800	COG4174	ABC transporter (Permease)
GPW74_RS16805	COG4166	transmembrane transport
GPW74_RS16850	COG3842	ATPase activity
GPW74_RS16860	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GPW74_RS16870	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GPW74_RS16875	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GPW74_RS16880	COG1011	Hydrolase
GPW74_RS16895	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
GPW74_RS16900	COG1970	mechanosensitive ion channel activity
GPW74_RS16905	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GPW74_RS16910	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPW74_RS16910	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GPW74_RS16915	COG0302	gtp cyclohydrolase
GPW74_RS16925	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GPW74_RS16945	COG2390	Transcriptional regulator
GPW74_RS16955	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GPW74_RS16960	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GPW74_RS17000	COG0583	DNA-binding transcription factor activity
GPW74_RS17005	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
GPW74_RS17010	COG0778	Nitroreductase
GPW74_RS17035	COG0640	Transcriptional regulator
GPW74_RS17045	COG0446	pyridine nucleotide-disulphide oxidoreductase
GPW74_RS17090	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GPW74_RS17090	COG1263	PTS System
GPW74_RS17110	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GPW74_RS17115	COG0840	transmembrane signaling receptor activity
GPW74_RS17120	COG2885	chlorophyll binding
GPW74_RS17125	COG0545	Peptidyl-prolyl cis-trans isomerase
GPW74_RS17130	COG1943	Transposase
GPW74_RS17175	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPW74_RS17180	COG0384	phenazine biosynthesis protein PhzF
GPW74_RS17220	COG4115	mRNA cleavage
GPW74_RS17225	COG2161	toxin-antitoxin pair type II binding
GPW74_RS17245	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
GPW74_RS17285	COG3040	lipid binding
GPW74_RS17295	COG0346	lactoylglutathione lyase activity
GPW74_RS17365	COG3093	addiction module antidote protein HigA
GPW74_RS17370	COG3549	Plasmid maintenance system killer
GPW74_RS17400	COG1418	mRNA catabolic process
GPW74_RS17530	COG0346	lactoylglutathione lyase activity
GPW74_RS17550	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GPW74_RS17555	COG3040	lipid binding
GPW74_RS17570	COG1605	Chorismate mutase
GPW74_RS17665	COG0456	acetyltransferase
GPW74_RS17755	COG1619	proteins homologs of microcin C7 resistance protein MccF
GPW74_RS17825	COG1403	HNH endonuclease
GPW74_RS17895	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GPW74_RS17975	COG1619	proteins homologs of microcin C7 resistance protein MccF
GPW74_RS18150	COG1418	mRNA catabolic process
GPW74_RS18155	COG1619	proteins homologs of microcin C7 resistance protein MccF
GPW74_RS18265	COG1418	mRNA catabolic process
GPW74_RS18300	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GPW74_RS18305	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GPW74_RS18315	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GPW74_RS18320	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GPW74_RS18330	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GPW74_RS18335	COG0509	glycine decarboxylation via glycine cleavage system
GPW74_RS18340	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GPW74_RS18340	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GPW74_RS18345	COG3338	carbonate dehydratase activity
GPW74_RS18360	COG1686	Belongs to the peptidase S11 family
GPW74_RS18380	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GPW74_RS18405	COG5000	phosphorelay sensor kinase activity
GPW74_RS18405	COG5002	protein histidine kinase activity
GPW74_RS18410	COG0745	RESPONSE REGULATOR receiver
GPW74_RS18430	COG3568	Endonuclease Exonuclease Phosphatase
GPW74_RS18455	COG0366	Alpha amylase catalytic
GPW74_RS18490	COG0561	phosphatase activity
GPW74_RS18495	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
GPW74_RS18500	COG3623	hexulose-6-phosphate isomerase
GPW74_RS18510	COG0745	RESPONSE REGULATOR receiver
GPW74_RS18525	COG0583	DNA-binding transcription factor activity
GPW74_RS18535	COG0798	PFAM Bile acid sodium symporter
GPW74_RS18540	COG0640	Transcriptional regulator
GPW74_RS18545	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GPW74_RS18560	COG2207	Transcriptional regulator
GPW74_RS18565	COG4604	ABC transporter, ATP-binding protein
GPW74_RS18570	COG4605	iron ion homeostasis
GPW74_RS18575	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily